Mercurial > repos > bgruening > hicexplorer_hicfindtads

changeset 4:8b60271e7e54 draft

Find changesets by keywords (author, files, the commit message), revision number or hash, or revset expression.
planemo upload for repository https://github.com/maxplanck-ie/HiCExplorer/tree/master/galaxy/wrapper/ commit dfa5a68cb20842407941c7ffda9ef956a0e86a04
author iuc
date Sat, 16 Dec 2017 16:32:17 -0500
parents f569cd2afecb
children db2cc9e1ff76
files hicFindTADs.xml macros.xml static/images/SRR027956.svg static/images/SRR0279XX_perChr_eigenvector1.png static/images/diagnostic_plot.png static/images/hicCorrelate_pearson.png static/images/hicCorrelate_pearson_scatter.png static/images/hicCorrelate_spearman.png static/images/hicCorrelate_spearman_scatter.png static/images/hicPlotDistVsCounts_result1.png static/images/hicPlotDistVsCounts_result2.png static/images/hicQC.png static/images/master_TADs_plot.png static/images/z-score.svg
diffstat 14 files changed, 763 insertions(+), 3 deletions(-) [+]
line wrap: on
line diff
--- a/hicFindTADs.xml	Mon Nov 27 11:12:30 2017 -0500
+++ b/hicFindTADs.xml	Sat Dec 16 16:32:17 2017 -0500
@@ -111,11 +111,66 @@
         </test>
     </tests>
     <help><![CDATA[
+Calculate TADs
+==============
 
-**What it does**
+Topological associated domains (TADs) are regions on the DNA which tend to interact within the region a lot, but not outside their boundaries. More information_.
+
+Calculation
+------------
+``hicFindTADs`` computes the TAD regions in two steps: In a first step it computes a TAD-separation score based on a z-score matrix for all bins. The z-score is defined as:
+
+“The absolute value of z represents the distance between the raw score and the population mean in 
+units of the standard deviation. z is negative when the raw score is below the mean, positive when above.” 
+[Source_].
+
+.. image:: $PATH_TO_IMAGES/z-score.svg
+   :width: 150
+   
+`Source of image <https://wikimedia.org/api/rest_v1/media/math/render/svg/5ceed701c4042bb34618535c9a902ca1a937a351>`_
+
+In our case the distribution describes the counts per bin of a genomic distance. In a second step the local minima of the TAD-separation score is evaluated with respect to the surrounding bins to assign a p-value. Two multiple testing corrections can be applied to filter the results: `Bonferroni <https://en.wikipedia.org/wiki/Bonferroni_correction>`_ or the `false discovery rate <https://en.wikipedia.org/wiki/False_discovery_rate>`_.
+
+
+Input
+-----
 
-Uses the graph clustering measure "conductance" to find minimum cuts that correspond to boundaries.
+Parameters
+__________
+- contact matrix to compute the TADs on
+- minimum window length
+- maximum window length
+- step size
+- multiple testing correction
+- minimum threshold
+- minimum distance
+
+
+hicFindTADs tries to identify sensible parameters but those can be change to identify more stringent set of boundaries.
+
+Output
+------
 
+- Boundary positions as a bed file
+- Matrix with multi-scale TAD scores as a bedgraph 
+- TAD domains as a bed file
+- Boundary information plus score as gff
+- TAD information in bm file
+- Z-score matrix in h5
+
+The calulated TAD regions can be plotted with ``hicPlotTADs``.
+
+
+.. image:: $PATH_TO_IMAGES/master_TADs_plot.png
+   :width: 80 %
+
+
+
+For more information about HiCExplorer please consider our documentation on readthedocs.io_
+
+.. _readthedocs.io: http://hicexplorer.readthedocs.io/en/latest/index.html
+.. _Source: https://en.wikipedia.org/wiki/Standard_score#Calculation_from_raw_score 
+.. _information: https://en.wikipedia.org/wiki/Topologically_associating_domain_
 ]]></help>
     <expand macro="citations" />
 </tool>
--- a/macros.xml	Mon Nov 27 11:12:30 2017 -0500
+++ b/macros.xml	Sat Dec 16 16:32:17 2017 -0500
@@ -21,7 +21,7 @@
     </xml>
 
     <xml name="colormap">
-        <param argument="--colorMap" name="colormap" type="select" optional="True" label="Color map to use for the heatmap" help=" Available color map names can be found here: http://www.astro.lsa.umich.edu/~msshin/science/code/matplotlib_cm/">
+        <param argument="--colorMap" name="colormap" type="select" optional="True" label="Color map to use for the heatmap" help=" Available color map names can be found here: https://matplotlib.org/examples/color/colormaps_reference.html">
             <option value="RdYlBu">RdYlBu</option>
             <option value="Accent">Accent</option>
             <option value="Spectral">Spectral</option>
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/static/images/SRR027956.svg	Sat Dec 16 16:32:17 2017 -0500
@@ -0,0 +1,678 @@
+<?xml version="1.0" encoding="utf-8" standalone="no"?>
+<!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN"
+  "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd">
+<!-- Created with matplotlib (http://matplotlib.org/) -->
+<svg height="432pt" version="1.1" viewBox="0 0 504 432" width="504pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
+ <defs>
+  <style type="text/css">
+*{stroke-linecap:butt;stroke-linejoin:round;}
+  </style>
+ </defs>
+ <g id="figure_1">
+  <g id="patch_1">
+   <path d="M 0 432 
+L 504 432 
+L 504 0 
+L 0 0 
+z
+" style="fill:#ffffff;"/>
+  </g>
+  <g id="axes_1">
+   <g id="patch_2">
+    <path d="M 57.6 374.4 
+L 402.497561 374.4 
+L 402.497561 28.8 
+L 57.6 28.8 
+z
+" style="fill:#ffffff;"/>
+   </g>
+   <image height="345" id="image8c8ebbe161" transform="scale(1 -1)translate(0 -345)" width="344" x="58" xlink:href="data:image/png;base64,
+iVBORw0KGgoAAAANSUhEUgAAAVgAAAFZCAYAAADdMDflAAAABHNCSVQICAgIfAhkiAAAIABJREFUeJztvX+QXsV55/uVBFgIe0yYzAgJLRG2/Hr9EiVYCpYBbzH2zg4OjAdv8m4krTXXluvajHXHCWU7t+q6SgOM9se1s9xikzGMzZbFXWFLyp3NlgZZWXRlGNY4WJHRpYz9pvxaCWMMQzTKZMWwGBxwdP8Y9VG//fbvH+f0ed/+VFFozntO99N9+jzn6ed5us+yf3hw27nh/3EHBvo3YGJkGpVaFY2pOljY45VaFQC454oQlS37jT7OO0dWZmyUSdZEsaSxYk9Mfbds65cfP7d/RwNHXv9d7N52UKnQVMTUuEQiNKrxXvTzUHT9nc7ygf4N2P5wBe/6vX+G0ckhABesUwAYHOvL/mb/rwt9vupal7JFDI71Gf0uK9NEPtO2hCY2eUSURU5APoMjyi1ke1RlJ+V6Ad374HK/2GuXT4xMozFVx5NfO4ra5HD2w+BYHyrVXhwen0Gl2gvgws0STeUHx/r4v52/nr5WpKxFZYv+5rkMWA6PzwjLHBzra/ldJoPJgI1tcIeSh9fnti9jIL5+k1GpVZVjmedaE5VlSln6Kq+Xpqwe3fuge57qWuC8i4A+sH/bj7D3725HdU0XAODI0y+gUZ/nXkwEMPWr2hBrWaZ1pSlb+5Pu8QWK6gtXV6cvljem6kvTmPNW5t6/ux07rzwCAKi/tJidqBKQvMlZ65I9Zgs91eJZDDoWE88KDT1t8KVcberPw2oo03Q+L3TvcVn7zkRumfFl4jp0QTTLlc0+ZJicu+y97/tKZsEOjvXh1s3rUO3+W3St+Bm+9dPrWgJfvMrYaT9gNs3mlcFTTOxvOuWpZHY5R9aGvLIdbFwXqvKS9WWHr77L6x7Efq9jmrXaXr+cXEwrx1f+4Up866fX4V986zNNyo3V+JVaNbN8eZYrC7GWeeez5+hczyph8h9PuZn6vngy6PpteDfC90CmFatr2aoXY0KMTd+pxmNe98DXy8DkuG15rri2VWZgylhOLiYBrSNPv4CPfOhh7N52EP/La7vwcPfX8MhjO1Cp9ja5EsiDzQsQqaKnOm8Dlf+Erod3nag89t8yWXXLDomoD10c8QkxrkENXlk6gdyyovO82ZZX5POmOw5UMmYuAmKNNurz2f8bU3U88tgOrBy5FecePIg//vbLmUKlU5toJcsqPXIeKc8EkXVA10FnAdgG3EJMlXxP3duV2KepPFx96XmOw6IpU5t8yMqW0eSD5U277xzehF23P4wTf/A9/N/v+XeYGJkWnqsK6JgMLp9+zBAdF4IQD26RAzxPX3Ss+G6vyYvbJY7gA1VcwrXMMtBkwYoehsGxPnzspmvwrifvxEsf/CN85EMPZ78D4uk8b/otmtq7MjjWp20ll+0mtQOd0ucxtjNGmXxSdPtk9a9Yc9VtdwPAQv1My4/d1R7cULsWh8dnsOYDV2P1b30Eax79A1wy/BmcXbkCjal603VsGeTv7mpP07m8umhhF+pnsv+zx0U0npiV/s6TSxdV3bbnxkIeMuvc8xiRycb7zVc7bPskpEyxUnT7ZPVLLVga8vvo5BB2Xv049j7/wcxdUAQhUq06gdQnYTDpVx9phIlysJz8QxaVJnsUAMDRY6ew9/kPYueVR3DyqXc3nSta888eV+0NwMKL7OkMQB0FbFJ/O1CkP5b+f6zYph2Z9KtuBo0JZRrLMcgA+E8x47GcFEYrUQJRhLNzi02+04mRaSx7ey9++f/8Zwz0b8jOPTw+0yIc73ijPm+dm0rLpYtruows5YytIySh6whZPunr2C0z32lHPEL0s8+xHJpYxoDIqPQpX1MWAVsRyY0lASS28tHJIXziud34rS9dzw0yuaYq2bgBQk2/isxgaAdizHLwgSozBohHoeSFbrvLfu91aFGwiUQikfDDcvoPduqgmsYPjvVl0/Xv/8efAWh1NVRq1WxPWXJuk5XsYbqi69/TqUskG69vEmo6uZ9ibHuMMoUglnZmCpanQMhy2NHJIf7v590GAPDQW/43nPzv66WVEV+s7+Vwun4l0RRVdA5dbgzLZmXEMqBYeLnVnUKoMeLSh3nKZCunSUBUdE4ez6eOfNlmL8AFofY/urOpgKPHTnEVTGOqeS+CF9/8AHZe9FDTVxAAYP3aLgzXNjbVwcs+cB04Kl+Y6DpVubplFRmEkr1k8lJqOvXH9mIqIzYvLdPAsCm8+0o/6yYKWBQQlQW+i0Cn7mXvfd9XzvGczfQqLN3gBLmJ91z/PRz/xxru23eySRDe1wN0oOvy6RjvBCe7Lqkv9GiHYKeNLD7kj6kP8iLbTYuGfPqFVWw0vI46PD6DRn0ex/+xhutX/zDbgSu7hnIpiHyaKv+sKkNA57dOje7KKKIvyugusO2nUOlRNmXatMGXK49HGceBLlwfLJ2Sle2GRf2bnM/+DQAD/Rtw5OkX8N9m3417rv4z7DmwFaOTQ9IAF63IyUBkj4kg56r8Njy/r0lydpGuARtikEn1McmyvuBs+9Z03JmUqUORY8LFTRe6fpNzTGnai2BwrA/oWZUpuYX6GaBnFbqrPVion0HjidnsQva3hfoZjE4OYXZuEYfHZ/AizuF3ProBlb/9r3jprVvw4plX0d1zGZ564ARGJ4ewYuVFWDjzKhbqZ7Iy6LLJ36OTQ+jdtAaNJ2aXLOvzMhD56P/Ingcq6Gt16K72LFnjVPtpXNdCZ33tkRj2TmD7q+g1475wbQe914ZL/5teW2T/8+qu1Kotz74tqr7Q2dckRP+0WLCs1diYqjd9tYC1Omn/6sTINNav7cquu+fI5Tj+K7vwz7/5SXzxw7/IfpudW2xalCB6s1dq1excAE37vrLn0z5jtgz2/yrnOc/SsvUdi8pky88LkRUZg8XbKYjiG6b3oKwzABpf4y/WvmiyYEUWGnpWtViILW/f89bsjZuuwuNTPwKwZMH85M038dE//DBe/cRnsfmOm/Gdl7tw683vwNT5lC1yfaVWbbISSYcvnHm1pfNuqF2Lpx440SQD+TdtfZMybqhdi4Uzr6K72pPJThNq9yHWKg9pLargWe20PKHkIrOidrFeddC1pnyPO9fxFXJ88qxV2U58IQlRl6jvloveHKrUmpa373krd/e2g00LC4ZrG/HNH/Tgsof+BL/8wv8OADheP90USCN10EEwum7Wl0fyadkgHP05m6xMyvokf6t8gyyyFBeV75dtS1HI0mhCQPrj8PhMtNZFKNiZlMkY0YU363LtZ52lrS5ll2Uc+LxP3pfKytK3AOBjN12DNZf9DJ++bw6AfANuWvnapniVAd2Hw+a82FJjYpYtJDGkOYXu76LSv2Im88HqJiKL3sa81CdixR4en8Hh8RmsX9uFb3z3OVz2Z/8Ww7WNGK5tVPpOSXm6ypUX8ef9resf1fld5zpdH6wPXy0vY6JoeOOj3dN2VLNAU3xaqCH6uKj0LxVFZRAAkm9y8R4InlC8m0ZbpaOTQ9lKMLLj1r27NuGKP/rX2H/7JI4eO4WB/g3c1WJsXSwmN4coeh+WsChIwf6uuj4WXOTRaSsQj6LPgyKs9LzHlMlsilC2MeCjT51cBCYC0EppuLYRp8++hp1X/Bds/r2LhZFt0fUyy0f1m+31qna5EJvCDYlOW8vWH2WTNxEeMiaEQS76RBGyqT3vXPL/fVPPYnZuEdv/9Dfx/S+dwp3Dm5qc4LzNv+kAlo05z1u0oKvYdcp1oZ0eTp2UNxVl6A8dy0w2dtrFDZLgQ8YE14LVmfryzpFNB0U+2kq1F/dsehKbP/omAGDPga04ffY1HD12Kjs/WQjxYDNr6TQ6td00RfWBSC8V5bJbTgJRNKLKVAEK2gpV+Uzp3//xyl/H9790CqOTQ9i97WBTWT4ip7K/QxCzdeIqm8m9kI2FsuMjGNnOhA6omVDk/Vhxycvvu1u4wMCCSo2f0F6p9rYsre2u9qC75zI8eGgRr1Rvw/ZDI3jyutuxYuVF2dLYpx440VQOuZ7Uw6u/u9rTVA+NayI2XbaIohcVyChCJlInvdSZhu6rWPuNxeST8p0I3Sd53lub8kPKlEserOo3cnxwrA93/+KP8K//+uPc83QyAUwjuGk6lwhBGlcJgPlkDCA253muBF7OqWxQqVwPjfo8/vLG/4hvXj+dbfrddF59vkW5uk7VbAJbOhQ9LVIRu3xlpMwpSSFIQT7KgvXh6+T5TG1Tn/Z/+Els/l+vyP4m8KxTmWVMX+MiUwhikSPRPqQxFReZBauKsomCRbzFBbzjvDJYyB4GlWovjrz1M3jqd/9f7Dmwdam8am+WqjU6OdQScKPLpusWBeNE7cyTmAIBedAJbQTynQHZpMHlie97XrYxpJ0Hy944Xl4p+zv56iy7CQuvjkqtmm0M0qjPY9/Uszj2r/4Tbr7393DPp7Y0nUtSuFQQ2XU3d9FVeCFuss8HI4ZBKHrh8WSjj/FyoMuGy6o40zKKzNTQqdO3wteJqcTEsq1ffvwcO9W2yRujA1Wsj1Q36EQ6Z6B/AyZGpvHIYzvws1eA9/eewPfmr8eu2x/OltsO1zZi39SzzkEsHZeGy7TLNdDmkncqy0s2LSvhRuybFYW+3+xYLHp86eT6+2A5r8EtiwE0pyGVWpW75SB9ncyCIeVOjEwDAN6y4hUcefoFjP35Glx9Rz8eeWxHdg3JlxWVxbZJdp4Klw7Xqd8mMKhzrshFIpLDtl6fxGaBiFBZ4ixFKlcdWW1XSMrqlI1xHUMrJCaLpFyQpmn51OamqVVkRdfEyDQqtSoG+jdgx3c/h39zzd0AzAasrPOKfpMm2vMe5Nkml1lOaELP/mTXuF7vg+WkUB4qn6Qq8EXDKkT6DcfrkH1Tz2bKlRz7N9fcjf/je3+IO/rWCRuUBco0rO68pkWxlRUb7aZcAf8WoaouFaEsNGW95+MvNLpbo9rIyga/Xa73QdNnu0WRfpEi4pn9onOJ4qPL05k2sMf2/85Xseb4GAbH+rgBEfrrBbJydXyzOpkPMkTTEB9l2RCLkpa9iNuBopSZDF+ymAZ/2e/o0cd0yjSVoWhY2aRBLpuoJovINcALqIkCTHT95O/9OxqY69qGZ+bfyIJdpC7fgSpZO3RxrT/WKWcibsp0L8skqy4rLnn5fXeTP+i1w6SxvM9q86jUqrihdi0qN69vWm+u+tQ1++FCtsxKtRfdPZdlH85bqJ/Bnn9/C9ZeCXS98hQe/v+68NQDJ7DnwFY8/sRz2P77N+Cv/+bvW/YsEO1boL1Ousftw32ya5V1K66nEa33NyGtq28fir6XOmOb4Pvz5eS4iQy+8b4XAYuPNCWAWrBQ7W2yJE8+vhZf//FvNeXG2livId+e7fhmFtFJbU20H7bjV3SdNwXr68EyKWd0cgizc4u4p/ItbN5xWXaMpHmFlDPRGaTxYk8n9h3b5qbNXtigkUmQR7SihBeIIlFEURYCfV6lxt9kZnCsL1OkRy76JL5/73N4euKlzJJlAymkLTw5Re2k5aTPMQ3SiM6LNdjjKk9s7XGh0xSET1SZFKpxEnIcmchlIgc7XpoULG8JqigCL6qYl5bBXtOoz2tlJhBXAG/3LLKggSyrXX7jh3Hu9DwG+jdg5sn+lvJ4WQu8VDEaul76ep3sAJ0Aoag8H+ik1YlwzX4oOok8ZsrcfpsxJUv1VI37kC83k8U9LnIE9cGy/lP639LVYBIfKi/DYaB/A2bnFrGluhq3XXEML170203ZBaryZfKLMizKgK6sOilrPttcpj5MLNEpMQrfsrTsB8tWZvMbgVh9ZKqtstjYxmVT8/NWMatUSfkTI9PYUl2N4/XTOHf2b9G7/w5c13sxd4pC5CHHZUnPRJbBsT6h7KqkaZ61n5cVkwUGDawMm99NieVhygMTNxt9TWzkaU0W2X7f7QyeRUDDU6C6lpPIgiR/05vAnD77Gj5+3fO4/v3PcP2uZDMZW7lN8R2ZDEFMVkSZ4Y3ZvOpL2BPqGc1VwYrwNZUFkCnae3dtwtq/24vG2z+Nux48nv3OG/xFKdB2p137pWztKqN7yydFtj9zEcgi3fSUWnW+DF7knudTFZXPm/LS5dDT9a/OvIBl/+TXUfnJv8NwbWN2nHVXAPzAnEvkUESeUx+TCG2MU9KYkQV+dY+7IHJLieoKGUw1wdXlaEuo9uvI3PRFAzqlig5KkY2w2eOmwrAKko3M6/gr6WvocoZrG5fkPJ9dcHh8BtvuXYG9F92BG/f8Du7dtQkD/Ruwpbq6SYZKrar9jS9WPtvouuvLSec8lRLwHbTiQbfXxws6ZkR+RBNlrItoybYsthEDsvHPi72YwDtfFh/x0Sc6z5DWdoU2pjXP90kLRabyuuWrFLtI1sGxPtzRtw5r/24v7vrhv1B+ldYnMU3JipBF5IaJqV86iRj6PQYZXDFpgzCLgC6EN4VXwT5MLbll55Urfa5IDtU5Teefn+5nroD6PH72CrD9T38T4/2z2HNgK27dvM6oPbrWF8/ajoUiZKHrTMo1f9iZVgz9zlqqZcSkH1esueq2u4GlxtIbIrCbI+hs+MJDVCavvEqt2nKc929W1qbzepY2ZSEbnizUz+Anb74JAPjBK1fh05fuw4uXbcF/Hvt2U72ytgnrYq4VHY8JIldR8sXYJyEpchzwxmVMhJYrhmdQ66uyOr/z3kYiy09kxfAsXV5Zxu4KKoh1vOf3seWVr2b+Zt1gkMrPqHucLTdvfPsEXdtRViuGoJI/D6uxLH2Yt5wxBJ+bXAQmkWcWkcLk/a3bcNpJzfPn6nRMpVZtCnwdefoF7P2f27HzVw9pXR/DtCoEvOm7azkqVMGNMhKD/DHIQCMKUrkEeX1gaiSZlCGiScHmvaJHBe8DiiK/Hg2rmFm5J0amcfziYdzzqS3eOtfWR21ar4kMOrOK0ITKXEjEC/vM2cYmXOIkIrlc6zEdw9pLZUPkVdpOv2XnkbQyth5yDvlt1+0P464Hj+P+Qzu4MvBkGujfoCWDLyXGC07I+kQ0Y1Ad84XIavGRcpMQE3t/2So2k7HqOgsL1YctClZl3pNzZOg01jVLgVee6N8yee7bdxIHPv9LYZ4vWWTRmKpny2tt2+/bytXNZvCBiYXgmk1RRku3SCUXU3+FtAZDEkqW5byHwaYymZLkKW0da4u+nvdv4flUUEtULtnAZbi2ES++dj2efmRl06YupC6yyKJSqzYpWxu5RArI1vctCljJEvxN5FXVpTpX9+uhLLFbZDxcHlAf7VXNBkPXH4qQ7cmj3cKFBiHyFXllFp0XOTjWl+3EtX5tFyZGpo0+1Cg6R/S3iFD9UHT/JuSk+3OBMvUFa8iI5G5SsHmtcNIljw6n69hzYCt2bzuoLUel1vqNMB/yAHFNn0wp04Nig8kLNnaKkLdsfeRCcxbB+S8NxELIXFJ2er/nwFYcr5/G/Yd24MT3rtNKEatUe5syHWwCfSw6Lhre1F/XFZDH/TVxobhMbYvCJNAYE65pcq5ZNDLjoUz3n6AjM9dFoDMV9iFcyKkzbY2rymAt9z0HtqL70oux6/aHnWTgEcLqdSVG103R9SfahyLHUrZUloYsLzNdHlup2X0DXXYdb1mnTj1kqSyw1A62LZVaNTv+1AMnmq59fOpHWFa5Ilt2K7redukwLVsM8NpR9BLDousPhe248XV9GfDdRlVZIftUutmL7G+gNUqsm8rFS6OSRbyNl8ZKpkL0NEUnqv/9L50yzif1nT5V1PQpZL1lnBL6wNWS6gSrPvcFTZb16Yxhbh4sr2KeEKJIO69itlzWH1Op9irzYenNslnfnUjupjo4KVY8JduYqi/5o6u9+Mt/eje+/6Wlr+3K9i/g1c/KZrtUsKiHyqtbRNAX7YzrS8TketWY9FGHb8pmcLDojGFuHqzOxTJrk/yno/QIRFmLlBDrJ2Xl5FnPorax+a6iwNLh8RnUX1rET677t9jfP4NbKl3cNsv6gq6L3tDcFJPcPpMgmEnZptc3zVSqvdZKoEhs5KNfIi7ts13JZFJnXi863ni0qdv0OtOXlO/x2BTkkilE8rtuHmgoxzJrhZoGykwCOqQ/hmsb8c/WLeCt37kfD/3KFzA7t9jyFYSYA0Kh5dMpv+g+yhOfQcOy9W3ZZAkt74qb/+AP76b3jST/8dDZX9L3HpTEAT041gf0rLpgFT4xq10HHaDiBaxk7V2on8HjUz/CXyyuxG8MfhzvXfM6trxjJW74l9djWeUKNJ6YxQ21a7OAGC0z+TddH/mNPcfFEc/bV5cuW9ZGH+iU3e6BGRrdoKHsnpLfbPq2yECYqF7yzPJkCyVvyHGpK3OLBZvnlEHXDeFTJpM20tY4keORx3bgqktP4Fs/vQ67tx1scV2EslR83hubslxnDi51l4F2bVeZyeueyOpp2a4wr8ixTsMbU3XuF1/Zskx+Y9so8tfSMtI+2q/OvIAXX7set/3aM7j/0A4cHp9p8nvyFIoM0XUiWXTLlZ0nus+qfhPJonON7rWx+2QT+ZKXD9sFWT0tebAunxNRXWdaZqVWbclRJchydFX1sJ+u6a72ZEpHdu3gWB9u3bwOB556AZe+/T3YcPkrOP4/V2S/i5TgDbVrhbmvvGkgz41g2kbVeUXkvvqaEseID7nzmtoX6ULQgZYvZjl1WLb1y4+fS1ObZmSWKFkee+fwJhx5+gV88cO/wLefv7pl5Rch5Go1nWvLMnWNXc7Y5UvEyXJZNoAJtlP2UClCLtfwFj5Uqr3ZEtdKtRe7bn8Yjfo8vvmDHty2+jv4J2+7UDadqqaDrhI2vdbEz21bv01ZPGJXXrZ+9RDnh3yeQhGrXK6o2sVdyTU41if0fYqQDUDd32xugknAir6Gl5fHlksHdQ6PzzR922vPga2oVHsxO7eI19/ya7hq2WNa8rj4jlXw2qDC50vAx8u6nR5EU6Ws62cXxRFs6rTB9GUb0vq3HS++xpmqXcL9YNuRENFzOsNg/6M7sf2WvS3bHppM4+nMBdOovU19Nr+Hpuj625V27lffz4gvolawrp0Q4nqetWCrDF2UaAhYGUL6hn1fl0ioKGJsGX22W4Vv35CNtUn/31W5isqk08fo3yu1pa0IyYcUAf5nU3jy+ZBV97joN1YGF5ls08qScu1sQrqIXIwFW1os2GRBtCKy7EQWbmOqjvsP7RDuJ+vjBWCDjrvDlwWrqj92Ypc1dvkSS0TtIggBrdx4is7E5yoqu1Ltxfq1Xaj9+s9RX7gS9+07mZ1jurIphNILrUhV9SUSnULmImDTklTwzpWVkU2hFee4opOCRf9btnqNVrS8Y/T0n+ya1Zha2upwYmQa33mhG1ve2HfBnUBlZtBfqBX1JSsv72/2fNFvvE/giP72PU1TvUDaHZ+pcCHIq16XesowTngyBrdgQ1kveU6zRW0YnRzCxMg0VybaVfD+3hPYdMOPleXZyBDqvCKszmTputFp/Reiva6BXaBZJ0XlIvCtRHjX+IiMsx0pUvasy4Bsc5h3dJ73teDkFiiedu2jGNoVgwyA5JMxRSCbrrPn2ZRtcy3PPUAvQuD93XI+9eVZcpx1L+jCc1vwZKXhfXnCNoXK5LhteZ1CbMn3vohBsalkyKuP2nIvAtekY1XUXyd/dXCsD436fJPVvP/RnXjrxW/gmfk3mhYimLaNyKLTziLf5LFYES7ENg1th/pjJUS/CPciIBUWhUvdpp3UMrWnglG8c9h/07KS4NXh8ZkLSvh8ed/47nN4Zv4N/PaL/2dTsM/UgmWtcV7gUJQhwSK6ji7T9F64BHWKtr5YQiiiEPmYJv3mO/XOtP4QyMaxLiGs3qh8sEWQ59uc1DU6OYTZuUUAF9wHpmlTKQiVaBdCBn2LJiofbDvC8+FOjEzj8PhMk5VLnx86bUomowyffltf55eZdk9bYlGlQ/LO070mVjpOwbI3zCYiLyuPRTSNJ//ec2BrU7m60xTZQgcT+XTqdMHVXdPOuLTVJh+6aHTbK3LHlZGOU7CuN4yNyOsOdPo8sh1kpVbF7m0HceDzv2zJNBChKz9PoZtmAbj612J+2EOj6y/10UeyRSQhKHpBRJlmRS2fjPFNpeb/8xSqMkPUCVz4MqZOHeSTNvR55P+NJ2ZRuXk9Fs68iu5qDy696jfxxQ828OKvbQZ6VqG72tP0mRndz/jQX5JtTNWxUD/T9Ekc08/PkHpVgVCTctnzQ92rotH9dJLqEzo6iD5HxJbHG5M2uHwB2QXbz8iYfL3ZNx0f5NLF1qmuo6DIii+yOYxt3e0cLEgkykhHuAhc0oYIwlVaCr+nrgP/yNMvAFhafktSvXj1yKbzLgswEol2RqUDQrkRWhRs0f6VEMiUCM9/ZRIYkq3gYmGVYGPqwr6yxAc7MTKN9Wu7ms7n5b6q6jT1t+r+rkMn+14TcWAazA5laLQo2KIsmjxSgLj1coJLrn0gSy1hfzs8PpPtxEWYGJnGQP+GlgUPPpKmbQaaaT+7ppmVVUGXVW6f2L7YfRPLzIzrIsirM0xWpvDO9dGJOgrFVsFo55eeV/L0+WQhArGw6f/ruidkx2hkX10A3FOCOiVVK4/177ErcdsXe+ztsqVUQa5YAjKixQCuASZeGfSeBuw57Pnsrlk+5PQV3Ivl3hVBCj76oYx9srxMbw7ZuvrQ01DaajTxu8rq5bWH/f/6tV146HNvx/5Hd7YoVxaiXGU5rzpy0di0i3dd2R4Mn3RK8NFkRmpDGfvE2YLN860is95C1OFaDiD2R+qmXZFzTx7txravrba2hGTtKqNlECtF9KWoTp9j2eRFm2YuFyiViyAWinqI7hzeJMyVpc+zfRhEv3X6Q5JI2FLqPNgi3Bs2Pkyb1Cj6GAlCHXn6haw8ttzMtUBlHqhyaGXt4K0Ht+lvU1eOydaNZaVMbjkb2r19LLL2llrB6j74Pm+4qE6dRQomfk5ybHRyKNt1K/OxnleiA/0bWpQsHeRic2d13RImaWYqTH1t6Ci4AAAgAElEQVSxunsyxIDtuDJ9QYc4NyQ+ZzuxtIlFJ8sGKLmC1fVn+h7QPCtWpw6bgTcxMt1yMxv1edy7a1P2t88pPL2oQfR7SMroigipBEz6w0cOcwzoKi/ZdT5l4CHra/ratvTBtovPkA1Q8dKy6BQucoz3DS6T+hIJFWms6CG1YEO+/WJ56xNkyfsu2CT+E2RTfK7/VdOXq6ovNMkPW36SctWjLS3YsmGSZsMe23NgK7ovvRj1lxZx9NgpboqMbvmi80X5t+34kPm0zJKVF3cfuMimO1PseAWrk6okUnSAm5LhpUKJ5FGt0iJfRtg39aw3l4EOMT9AiWIJnZ9rUmdRZeWiYMvwEIZWRAQfipmUw1qVD33u7bjxxqe0+7vo+1J0/YlEaDregnWhqFVsIkYnh3DTNd34xnefa7F2CXlaFL5eJrER44shRplCULZ2ljpNi8Y2OCXK+9QpzyUtxjQBXzaoyLWrL78UlVe+jnuu/x4Gx/qw58BWjE4OKVOvTNENCPquNxZ0U3REhAjw+pwWx0zZxlOh2xX6xHa1kUgJyPyysnp0B4APFwErw76pZ7G5tgxHXr0dH7vpGpw++1q27SGvTpmFKXsB0FkNeWRdlAGTxRwxK4mQM5lQ59tek0e5yUXQRtCBsoH+Dbil0oWvzrzQkiublxzk30DcSqVodLJFEuEI2ddt4yIwJS/LyyUP1hR6kEyMTOPRxiLuWfunqFR7s299sTLI5PaxFJSdIRQ1hY4ZkxlUXvjOC4/5nobsa6GCdfFphsKlbPZaH52qkxMqe3hkSsxFERErdmJkGgvv+RTu6FuHiZHppi8nqKa0Mv+py5RPp8yilQuPmBVESJ+uzyXYZcemn7VcBO04XXGdlhWZbyfLLySQ30cnh7Jj9L4GtrLr9Fs7jpeEPWUYD6Fk1HIRFNE5vOksi8ubW9eyNAlmEZnpa0yyCnQzGngBPTJAWEV39NgpHD12CrNzi3jksR0t2xnS3/jSQWc6qxP8itki9EVZ3SGuzxtvvJo8EyGedxWhdJxRkMuXlpeVE/ptx5bP2zCFd34eVpprmfRiiabPkdfnMdC/AbNzi1i/tgsTI9Pca3zLY0sZLB5dipoVxURZAp0h+l+pYMt002Oa9scCO7gzy7za623lWuz+0wSfdhzvsaHMg/UdDAqJavrqksyvc70JefZJUx+cdxF88cO/8F6HzmKIRD7o9HeIxSdlJVSurtc8WJs3Yt5v0Rjf2nnkQbIDYqB/A1Zffil2bzuorEtHFh/yxnhvEgkXVqy56ra7fRW2UD8T7JpKrWpVvm19IWHbwpOJHPPZ7u5qD4Aly+XsyhV4HcDwZ7bgyrVd+MvDPxbKqFO/D3ljuDe2+LpPnUw79mHQhQas1eQ76m8ri+6GzqGSrE3awrNseRkOvH/z6qXzGxv1eVzXezE+8eKe7HySVUD7bFX9xXMp6S5UYM+h08rKROyWt01mS974fMZ5f+cBW2duS2WLnP6FDHTlkQ9rW4fsOpI9QAe9yEIEl2WuqgwRWXnJRZAIiSgjSHauK00WbEx5ZjaymOSsiq4X5XCKjtlueMK7Rmc1mMoylOXvjk4OXVByzNdbG/V5DNc2ZkGwSm1pPwO2LDbXVydHl/6NbSNdnm1fJswouo+Lqt9kdZqvF32TBRvSgkjWiRgTy5VVRD5XZAHAI4/twDPzb2Df1LNL5wnSuVhrII8c6U4gtT98+/MIKhOaLFiXClxToGIhz7erjpIUWYi0NVipVbm+S1lbRAr9Ix96uOmzM6yly8psYhUAcv93jMolxHgwvS+6chRtmfogj/uvsxrRF5kFG+Pg9oWPNCSX822uYwNNJtcBFwaMaKUau+qLPWd0cghD71mG0T/5SVN5pvIkiiWWe+U64yormQXbzg1Xtc00QZ43vQD0P4utE2Gn6+AtlpD5hGkOj89wryfKdXRyqEW5VmpVzM4tYvqvznH9pvTfojbrRK3bweJSUbTlKRqroZDFQdpZx4jwlkWQp1+jTJS1D8iDMtC/oWnvgoSYou916PqTn90cb1kEefo18sDXm95XH/AsRRMZdTIPyL/pB+CWShf2P7pTKodPymjVxjL9DV2/S0DVRzllpKM/GdNJb1JTKrVqUwbBI4/tCPL5GdbXDHTWA5hwJ+bnuGM/GQMU+yCbrjrxbdmpLFqy0mtwrA/3H1pK3bKRR+YzBuSfl0kkyk6pFGzR00eX+n2lsZnKYLv4glay9+07id3bDqJRn0el2mtkMZimcclkbjeKSAkMJUORbYn5pVwqBevLB+Srfh8+a5WFx57PywjgoZpuq3IxRT71Wzeva/oqgm6ZusQ83fNNnu3UWSUYovwQlGl8lErB2hLihshWX5nIYGPhqcqU/aaTIkafy3LfvpPC32zLp89vh+WyoeQve790Irko2HYcGKEtgpCwFqoqd7Hp3Gov1q/tAoCm73llLgVB2eT/9Iozl5dLzOi4X3j/di1Xl3Z8HmMlFwWbd7JzjOTRZh0/m0k6Ha+8w+MzOHrsVOafJRvCiCxPtmw6p9bWP1x2RItICKHHSqgZXSc+1yo6Ok0rBD59iD7KkrkyfJU9ONbX8jFFH+Um2osy31db2TvCB5snPgeQj7J8uDJUlub6tV2orukyFw6t0+UyP4QhaCer0MR1Ehu2Y7IQBRtrR8Yqlw4h17yr9mqYnVvErtsfxp4DW43rjjUPNpaxEEN/5NUXMbTVFbavClGwJpFi1Xk+lm7yUpp0l5bqlh3qfJ/Y3BPii63UqjheP43Bsb4s+EUHwcg916kjhs/GlOlhD71IJa++KHpjHB/ls30V5SdjdM/Nazppu4QzD/lUdfB+Z4+JtjQUlQfwty8kL7tbN68DsJTSRef7EiXbkgNc5W/qXRZC3Ge2n3XuY0KPPPVG6YJcRQ+qous3hafYbMoA9F4w5NyB/g04euzU0rHzCrRsfeeLPB/odu3f2ILHunh1EdhMh02X8NmsTGJ/o3MzTV0BPlLO8pwKsbmmpFzVt7XYMkyXxgLA/o+eaHIhiIjF3ynDRn7ZiylEm2NQrrZjW3WdTYDMNg3Q571pUrC0P1OklGSYKh/Zg2tiLbHns/WyZdFKR2c1FE8J6Vp1MiUtSzgP9VBmbWc/euhxBVVjqo7ZuUUse+cmnPzv63Hn8KalPQyqF5bYkrE2ONYXhWJQoeufZ6/xFWtwwWfZtoqQfVbZse86BnTyu03umy+sXQSh/E4yn5OPcsuIb/l1ynOtk1z/yGM78JYVr2D6r85hdm6xyddbhvuSR1+ZEiomEIsrowzjQheli8DWzLZBtcKFRmb9ycq1QWd6GNICcclZ1bWgfUOCXl+deQELr1+BTzy3G1uqq7lyxIxOX6mUhc4xU5lsxoTqmpD3QzTbzFMO1bMa4nkIGuSSBVhiiLC7QH80sIz4ssxE51RqSxt2E1fEQP8GDL1nGY6/tBLH66ezvmsnayU0pn2V+naJovqhUqvmuxeByVvMFbZTXd5OvGvLrFwBvf6nfWWmMxkS3CLW1tFjp3Dq7NuwZc3rbatcTQNhpgEh076y9au7WnI2we6Q9RQ1xhpT9fKlaYUi5oc9ZtlEiGTe/+hObL9lbwESdR5lHDcuxNheax+s7XkxkadFrapfhqmPLyS6vm+RzN99bgHA0motkiYX89hxHf+842yKnE19OvjMDCkDsSlXQJKmRbDJf9TBx413zSf1HewJPeXj4VqG7lJjXqBElZJDL5UlHD12CpVaFasvvxT37tpkLEfe6KTLyfzQ3PSh837pPFxnMSqd2F6qIWWRughiNLljQhbEK0oWm/NCyc/2z+BYH7ZUV2P3toOo1Kq4c3gT3t/1GMYerzQFw3xtexiSGO45Cy/uEIuMMchSRMpdIT7Y0Dm0RZQVSw5hnqiUNZtpQStckmHwtTvXYuqHq0qhVH3D67+yZ6fYENOY9s2KNVfddnfelS7Uz7Qcq9Sq3OMuZerC1m1Tlkv9MdQzONaHxhOzTcdU94T3G32s8cRsU7nd1R4s1M8sndOzCo2pOh76+t+gd9MaoGcVbqhdi8rN64GeVbn1Z5Es1M+09DF7Dwiuz4evMkKgkkkld1Ht0qk388GG8kP4TKUIlf5R5NszL1+06jzW0gTs/epNPkVqSS4ddCEuA5r1a7ukX60tE7pBL5cYh86iEpu68sLX81lkGpaKZe9931fO0SZ6O5rrrm2y9W3l2Ze2SlFVpszHLGufaR+RqfEjj+3A5+8/2RZjsB2fpVgoS98uB8yWqJYRn75Zk/JCpcnwyrRdPqnzm8uyTFkqEvHFAsi2M3y0sYiv3blWu74iMLG8RO03tT5tzxWdn1cUP1S7yqKn0kKDRDBsZkbEbdBpgZ5OoSyWpy+0lsq6vu18vi1tylJd4yJfnj7UsmEzMzo8PlMq5VqkdeiLPK3ZvF1mqmOhSRZsIpFIBCJ9tjuRSCQCkRRsIpFIBCIp2EQikQhEUrCJRCIRiKRgE4lEIhBJwSYSiUQgkoJNJBKJQCQFm0gkEoFICjaRSCQCkRRsIpFIBCIp2EQikQhEUrCJRCIRiKRgE4lEIhBJwSYSiUQgkoJNJBKJQCQFm0gkEoFICjaRSCQCkRRsIpFIBCIp2EQikQhEUrCJRCIRiKRgE4lEIhBJwSYSiUQgkoJNJBKJQCQFm0gkEoFICjaRSCQCkRRsIpFIBCIp2EQikQhEUrCJRCIRiKRgE4lEIhBJwSYSiY6hUqvmWl9SsInoyPshSHQOjal6rvVFoWDL8EC5yhh7G3Xk020DfR75t+xa9re8HwIZOvLrXG/6W5nh3f9OZdl73/eVc0ULkUgkEu1IkwUb6m3jq9xOfxsmikPHEk3js5VKrarsFx/9ZlKGz9maiiYFK5qaDY71OVXSmKrnOvhcOzs9KAmWic++K/v34Fhfk1Il41vm2tBVwiHGXpHjOS93j0k9Ouf6kju5CBKJRCIQUQS5iiBZqYlQFDW20piOj9IqWNfBFFOkOlEuVGOvqLGVxnR85KpgfQa70mBKFEVjqo49B7bi6SNvwyOP7cDo5JBWMIdHO1mduulZRbS5qH72qmBt3uw2ASlSTojcxIRf2rWvN/zKKjRW1PCWFa9gYmQaQHMwVxbUopWxraEQY7/SbZE9o+xvebSlKIPMq4K1aYSJ0mXPpf82ic6Wzfr1nYKSJ7J7FJusJtz14HHc9eBxXLLiVZz43nUAlrILdDIKGlN1bSNB91mIDR1jyOT5LSvL82iY6ZvKpuNVA851QBZpLftKQSl6ELvOYIqEt9qsMVXH1A9X4Y1/vBTDtY24dfM6AMBA/4YmBUOnOZquWnOdrfnERQbdF44vGVxk9dnXy01voGnl9Nvc1sI1VdA8S8l1+Z6tcvBpaej6tWK2etiZBCtTDIoE0JviV2pVTIxM4xP/18sAgGr33wIAJkamm6fL9XllPSp0cslD53SbKEGdc0POaFzGus/nJLo8WPbm8G6WaZBrcKwPh8dnlHUl/EL3bzv3NWnb4Fgf7uhbh8/ffxKVai8Oj89E1+7Y5PFBzG2y9sGGsjTYN7VIuZq8zXnKlVe2bnk+zvNJkVafrG5e0KNdGZ0cwpbqaqx9/RD2vvofAMj7RrQ6MvS9LOI+xNIm1f2wzQSR4WzB+nh7+LBSdctNxE2Z7hk7M6rUqqhUe3Hr5nXYcu4Ajrz+u9g39Wz2u2pmlhc6s8SiEM0288K1L9jrnRSsb2F0zlVdE9NgSSzRKfck89tWe3HP+5/Gsrd2Y9sfr4qu7Xncj05xD6nIXAQ+Aj+mZdDX624o4yNbwNS5HkvgxYYYZFfdkxhkFKEKLFZq1WzsVqq9S4G7+jyOv3E7AODA7/9cWpYqmOZTXkIeyo51D+X9jLlO933JmylYH53uUoZqWuAz2mw6PfJVt+uuZCJ0/aCxKrKYrRtVelHT3/X5bDztuv1hbPvjVcDFb8HJp97Nvfe8vFk2/mA6ZlTZLqYZOSJcMhpkObG+FJtJ6hevfF9pn7kslRV1Sqi8OlVdsiBaiLoJoXxLurmvsSmyWBW+C2wfj/35Grz42vVZjuzo5FD2GxkPsmAgyUQg2DxL3BVW1V5ZM5ToKCBRSp7u4gObemlEM9U8x12TD7YdfCXt0IaY6dT+lfkURX0is0ZVL9t26GfduIltubLjsfSf1obbIQiZ5uUb2TQtJissD1l89G9MfeaK7EFmYwzr13bhjr51TQsPaIu2yVLlWJhl6zfVAiPaf80ep/8vKld2PBbX2Io1V912Ny3IQv1MLhXnVY8XelYJ5Y2hHeS+xSCLDmWRk4aWmfxbx0ra/vs3YMXKi3B4fAa9m9bgpncuw/DaRzH36wNoPDGLsytXZOXRdTSemJXKIIL3DOf1XMvqGRzra2nTQv2MtJ2+ZLYpx1eftYUFa1qWbuCARCJjmGrI0PXBFoWODzF2bOU+euxUFvw6PD6DgZsPYdnV1+Ke9z8NQB1AdcnMER3LY/bI1sHmCwPFBH3zJrqlsiJiUnQxyRIjqX/EkId/oH9Dts0h+7vMv5uXPzP2sl3IM5demUUQy9vA941i/Tw67dRN4YiJIu6fS4ZH2TAZN8CFaPrEyDTuP7SjZactOkjDe9BVwTSZTDZRe/o6H9a0LqFmuHTgTYTPJfRKBVsmZWKCzsBVXaNDaOWhKj+W+ydTArHIyEO1AEBnEQVv6lypVbHw2hu4dfO6JquWvkYWHKLhjWUTZapqI3u9rzHtS8mp4AW/fJWvKqc0LoKiiXW6wyMmWWOSJTSqdC3ebyS7AABm5xYzX2XM/RaTbCayuMptYxSU9qOHISDTMt9lqn7TqdMkIOA6+H0mZOsGWMrsJgDU6Vrs1J/8RxRqdU1X06IClbVp6xZw6WdXF5lPy9dGFtfngtxHk3KSgqWQdZ7tzdFZaqnlnpBs2sziqsR8T6N4ZeseLwv0tFzW/2SMkX0LKrWlTbvv23cSew5sbXITyMoSBb5U997E5yqrUweVK8OkbrYcUXt9KHEfLyGC02Yvifz6zceb2tcAD00MMsgQJceLXkyVWmtC/eHxGQyO9WUKtTFVx/H6aQDA/Yd2ZMdZRPeQlC+KLbiOH1FQWOVH5bXdF7pBQNG1Iny+7HP5JpcrrlNWk2lVnpFSHfK+P3lbkraR7SKh/aT0/0U0puo4PD7TYnUeHp/B7NzihfPq85idW8TCa2/gk+/4LkYnh7iWGs8yJDMc1Ri3HU9EWbIKW2Y5k81sRMuCXe8925+iPvI9xkyU84pLXn7f3YB4tUOlJl/RoPrdBVI2vbLDRh7RyhBeOfSxkG3TxbT+Sq2K7mpPVO2Q1V90/7pAZO+u9hg/sOQe0SuZFupngJ5V+EF9Hn03vhcrLu7CT958M3sG2OeBJ4tqjLv0t+xa3nir3Ly+aRUkOw583nu2X3ir7XSfA96qM7YuHrzyvWcR5BnV0yVkPXm0IaaorSvt1hbAbFramKo37drP6w9S7r27NuGZ+TfQfenFuG/fSTSm6hidHGrKNhCVwTtO/mb/ryrHBFHZeVN0/YTgaVqukUfTumTR1xg63Jayy9/OsErF5LMng2N92fSed3//4i9uwDNn3pkpWF69pAwdJSuT3xc+0qFs22Jbv4vMsmulCrZTHuqQNy5vQstYhj4oAzqGR6VWxUD/Btx0TTe237L3gs+32tuiwIsyLkQWuE19oRR9ES8ZgjRNy3dji4B1fvMoWmH47BvXVBrf5Zcdm3tjmmoku25iZBrbb9mLwbE+3POpLQD4e8nKNtAmSkYll01beeOBTllzLd8HOv0sklmG7HzyW255sEU9mKaJwTS6eXyuA6fIF1lerhv6/2XCpn90Hmid32jF2KjPY/ste7Oy9xzYml2vkylAPwc+06ZE8tv0QV5uCuFzLHlJmZRD/5bbUtkizfQ8prVFf244JGW+LyHQlVtnTJi4p4AL+xUcPXaq5bqixqCrzzRv8uynpg23Q6KTYmWbKqZTd2hkaR1lJ1T/lTVFSzaW6eM6Y0KUwkQgKUPd1R4AwDvfcUX2/7MrV+CG2rVAzyp0V3vw1AMnpPK4IipLVD6dLmgjR6j0Qtl94aU56sKTN9ePHtq+zUyuK+M0NA+K7Jcy3xPdKbDouG7bheVRGQaNqaVtDmfnFvHJ3/wx7hze1JQ9oHLFuPpFTSxt9nwfrhZddNtEn0frKNs4Bu86by6CGPNfE4nYsX1uKrUqKtVerF/bhdWXX4p9U8+25LgCEKaNlTkH3VeZefSBt70IZEvmROfmRYggS5mtMh6pb/JBN3DKu4aNdDfq8zh67FS2hwFdXpP1eP6TNTry+MYmMEwCd6azB93y2XJsLHvdfssUrE4ASocYLVPeoPNVpi286YnqPJ+wL52Y+qYs2ExFXafKJNJNT2Xv2fQk9n/yZ9hzYCsqtSr3KwmiIJSu3DbIxrgsLYrIayKzzYtLdq6vMdzkIohx6h6jTD4xSYZOFEfe01LZeexv5NPfqy+/FLu3HbSqL0byyl5xrUd2fctXZW3fWqG2JCvr4NDFt3XtYnUUMbUvizuBfSB1oM8zfT5UOZakvEqtiuqaLkyMTOOfX/08Zp7szxQu67OlYa1cnTa4nGODiz6iUVm3rs8eb2yQ/3f8J2NUb69kYSZssRkzui4b9jyiMG/dvA71lxZbvlgry1XVqS8kPNlM+kGVg+tj1mBLxyvYWCjDdMi1rHZejCFD9rC7Zt9Uakv7FdALD8jmL5Vq74V9Yqut+xcQRieHuAsX6DoAu2XYJm2TyVg0ts+NUR5siKlAWaaIIfGtXGVBFZd6XMuK9eHxjW4AUTaF5x2jXQMt51abl3kO9G/Alurq7G/6e1/AkhImf0+MTGst+zR1jZgGmlzGh27Q2BaRlayqy0jBhrCwyjDtLiqVxbZuVfTVV3vYcnz562J/6dLKCWh90Hh+dVbp2Ea9eUro6LFTLccnRqaxe9tBHPj0aQzXNmaWrqwcGSYJ+MSlxr5oQt5X3UUNPse+Tp80KdiiBnbsDxRLnvKGfqm5tMXEojWxamJ/6bKff9F50Hh9peP7p/9WlUvOoa3VH58bwpY1r2Pis+/KPk8juhe+A9Xsi4Z+ubAvKRqTvFTT8asKnPlOR23JIrCtkIeJsDxryJcikw0cnTpcpsZFvjx08i/zVGa6D04ZXrhkfMosNaJI6GMsorGp+xKkFTFtOZJjdz14HN3PTmLh9Su419L4dOHQ8rNtZN0BOi4V0/Er6zNf6XaqegCDIFfIiGiifTEdN7Fma9hEpXnX+ijPRDYSPPrCwEV45R+uxEc+9HDLb6KvIYQmj+BZKHRl0HIRqJzxIthpkMm1qnN9WdY+rKUyWFwu+HQjyCBfIY0Rn5kXqofTNJhE+1ZbFPn54Nd/OPom1r46hT0HtmJwrC/7Yi3va7c22PjWbfWDjdVKfvfpatAhpWkVQAxvYEJoWWJqq09iaheRhScTmZ6TdK2B/g2ZLzavrA6ZfHnVIfud9xL0Jae3zV5YQr4JfRKqvtA+IBt4MoWWxab8MswIXPstxMyJjd4DF5RoY6qO4dpGzM4t4mM3XYMt1dUYHOvLvozAK9NXHMQkF5aVwaQOdqbNxiBoJSuTz+czsWzrlx8/V8QDr0o6l71F2sWv50JsbYpNnphx6SvWb8paZuS5YpUJa6Hd86kt+MZ3n5N+0da37D7LCEEIvZJcBIlEYGQPYujVbSK3QaM+j+HaRuybehZAqwJmswBiXiSiM+0vCqcvGpRhKmdKO7YpUSyymZip4vIyZT9vte6behZ3Dm9qCpIBrfLyNutmZbEJHrm4BOgydKb9OvKozrORM1mwiUSJoV0AIstTdg4APPLYDnz+/pNNexeQc0Ynh7KNY2QBJPoa3u+ywJPqPNFvPlPdTLFK00okVCQLX4+8gry8FWGkDDrAxa6movnIhx5uUq50OfSuXDIlKVshJfqNPW6qIFkfc55jU5RexspQSgWbHvJWeH0SYo9e04iwKWW4tzoyiqLZqnJdFIVMiarqXb+2a2nPgmovNyKvqlNWr8za05FV93pXt4COHKpMHFaG5CI4TyxO8VhI/VF+RMEp3tSczUwgWyACzS+LPLMNZPKq8mpjGb+ltGBDEMPNCIVtXmGiWGwDLayLgIWX90m7ByrVXkyMTGfWLH2e7ljyOX5Eeaoyf7ArJv0so2Ms2DzeaLG8NRPth87Yshl/7DVk820ATXvM5pmmVeRzpArYya5jLf1Krdp+FqzorZ/HDRMFG9qNUO1q1/4KjUwpsN/ekvXx4FhfZrkCwJbqajTq85lybaf7IwvI6bzIeNex/25M1TvHgk0kyogPq1T0m27ZOj7P0NhalmwZumlhJuXIaDsLNpEIjU9LTpXpYaMAeDMp8p8q6s5r28Rn35UFwtjfVfvdijD1caosSx1/ta89B3SyK8hvUViwyXeZSMhxteB4ixB09iGgr9tzYCt2bzsoPNf3klpfFmcIvC80COl/iaXT2pF28pvFRN55vra+Qfp6GrIPLJ0ZIPItks+7HK+flp7re9mvjqVYBEFcBEkJlpN038KQV7/mEVBULVAgynhLdTWGaxtb3BomiylodPvQ9wICV3eGSvHTx5e73MDY3iw0RcoWc78k9Ah1D0VLLHXOV10nO5ddzqkb3KI5Xj+N3dsOWn30Uad81Tk8H6pIucuWr5rKYroKjT4ehQ82kUjo4cMP6VqGaKVXkcTqn01ZBJaYrC8PWb4PksVdHnwoEZu0L/Z63kovV9h6ZP5eVYaA7DpynOfqYLHZz4OWJSlYS1z9R6Gu00U29Urkj0i5mJYRIl2K9TnSS3GPPnE7RieHmurW8U3yZDZJw9IZs7xzaHdGy+5h5xdY0HXR2z3akFwEFDFNM1hili3hj9jvM/tJGmBJ5uHaxiyFi6SAiRYn+G6jaJmqaEGFiUymx1mSBUvhc/cf38QsWwx1xYCt1fdRhYIAABJCSURBVEnj6z6H2KoSaN5jFrigaDb8yioMjvVxlSuvja6BJxG8jAidBQaizABRUFJ0nL3em4Jtp4fJpC2i3MFYyVO2mPshBD5WXfkir0/RkGn19lv2Yv3aLtzRty47Jlte67Pdoj1AbFwWMrl0sgbYc5KLIJHwjM8VSLG5DFTyjE4OYXZuMbNiAbsVXkW123XFHEshK7lUzm5fZbYDPqdSOtHYUKjqaaf7J5uSmgazbPJVeVNWWfTcBJW1ePTYKdx161k89Lm3Zy4Dtk72Wa/Uqi0y6So4Wf/Zjimfin3Z1i8/fs7V4ctD51yThGcf5/Ec4Ak7TMdCpdob9aef88Jm7Pl87lTPgK882/0fPQG8vRt7XxzA7NxiS2CMQBQr7bcl+H5GdftG51zdOpabOHxN0FGuqn/rlsU7T1aO6WqadrKuCCr/lAqTwdeYqjcp13bqT1Xupmps62Da1zL5eM+AbV0sWZurvbircRvmLqvhlkpX9hudBkWnetErw2xWhWnP4Jg0LPbeyHypunWW1gcbyvoMbVEUjW+fUiIudGeKQPgxQKdw3Tm8CQBwXc9fAwC+/fzVOH32NUyMTGfnka8n8FKsQsnrI0XLBKkPNm+/qOxtr3rzmqJ7E62jq5FYaSEtghDE0m8qRDMA12fGFJ2UJ5sxYEqlVm2apey6/WHct+8knjnzTqz8xU9x29rj2XkkwX92brHFaiRKTaTwTOThzSZsU7R062SRKlgfN8ZkKmry9tKdeuma8jKZbK6N1WLUvQ9FUZZ+k02xTV1QqrpcA2GuCl/nGeZNryvVXhx5+gUsXlzF6xetwSff/X0AwED/BqVs9PHMT2voKmGNMtX1rmOP97JTWrCuFZpO603PYx3TtuV1Cq6Wgc35nYAPy5VnXLDPjs298qE4WLl49bBZCo36PBr1eXz6vjl8+/mrl86r9mL15ZdidHIoK5NnYdJ16frv85xt61IaH2wikSg/Jj7QdiAtlXXE1C/koxwX8qwnWbr5I/MNi871CS/HlowF8tt3bvyvOPn42ux43jEC38+hLHPEuwUb89vINhMhReLtiHks+KJMbeS5G3xEz0VWKXDhmWHzXQfH+vCxm67B9lv2Cq+xwfV+0KlmrnnblVpVrWB9DiCZgivzQI2tvLLKUGZ0+6+ofs6zXlZRip73ez61BQBw14PHsxxVHaVm+wJg4zU+AviqMrguAtMopi4yZ3lsD7duxNRHPT4WdrgSW/+XDVWCv+l5vvFxf1WZO/QxVdJ+Y6qO7z63sHQdR7nSLgXetTT0klxZoFtnIYHu/dB9blesueq2u9mDC/UzqNSqWKifyf7rNPJqM12PrE5yP0yxvS7hhk6fiyy77mqP0T3L6x6LxiqtK4iy4clDziNtXLHyIvyXRxu4d/gi/MMlV+FFnGsu48yryr6o1Kp46oETQM8qLNTPoLva03KNTv/QbdC5Rve5FQa5bN947RjYcNkcw7f1n9d1vgg1Gyoz9BRaZnHp9JXJVDdU37OWIdsuXg5xY6qOWzevAwB88wc92LLmddy7a9PSJ8KrvcrP0Yj8tTqLFHgBWB2LllzHu17Ut1IfbPLLLZH6IREK2yi6rr8XkCsPG7+xKDeXN3WX+VTpJbOrL78Up8++hqPHTmGgfwMmRqaNZIoFVi7lSi6TgmV/+yREmkZePteQ5JWKE5qYZBbJotvXJKFehM3YUllbtMKTla+7gIFnJbJ/01Y3KYsoV1HqGNm3YGJkGru3HcTEyDSGaxux8+rHhdeIZKDRuWc+x5jI9wxoBrl0UN0En/hamWJbZkwKgKYMwUMVsVkmIllkfU2Pj4mR6eDjhbUgbZSPzTWiclpSszSUPDn39NnXsOyiS5q+imAqj46Lhef7pgNrvu4ZV8EWOcBjVV407aCMi0CnL2JSribIrJjQbRIpFJl/16Z8Vdksh8dnmuIXMsVHrN3ZuUVs+9pqbKmubvlaLTsbUClEk0wB8mLgfdBRdr2qz72v5HJVKL4Ho26gwHeZeZThgzzlKKvyZHFRXHm60nhKwtfzoNte3j4CIrkqtWrTp2aA5o1hjh471XQ9UYg82WWBLNULQyfFTNZH9G9pL4Lz5D01Zd+SqimajWyxTbdllEnWWDHNKGAVhWkSviqIZiMn+Y18nTZzFZz/N7Ewbep1hf1iro4M3DzYTiTvXFE2j06Wd6f6XacOGpuyQhObPDEjun+qfFE6P5T+P5vrrnsvTPJG6XPY88jxwbE+LJx5den3nlUAgFtvfgfW9bwVV67two2VHiyrXIGnHjiRlTE41gf0rOLmy7Iy8WTUOYfQeGK2qd94dQ6O9aHxxGxWTsdbsMlyShRNu41BUXtM20mfT/yvvtO4WEveZCapU0fH76YVYplqLP5VF3y3oR36JBQxK1eZz1gnI0EW/DMZE7Nzixh6zzLcObwJR4+dwuBYX6Z0VcEuWcoX629lzxkc6zN2SSQfbCLRRviyGF2v8w2r2O4/tANHnn6hJRCmWtAgK99kEYZNv3S8BZvgkyzO8mCSq0uQLf9WKZE8xgZPme26/WE06vOY+Oy7mi3L+ryX3H3f5wPAclWeVyJe8kjxScSByb3WSQVTWXwmSfoucvBSteg6aBfe4FgfGlN1TP/VOXzxw7/ItjvUZc+BrdryqlKxdFlxycvvu5s9qLsTUCyRX53ooM+yXc7zWW8s/Z9ww9e9FkXpbcaJj+dJRw42e4FkE5DMABKpX6ifyaLzK1ZehJ/9/ApUey9G9w3r8dd/8/dKmSu1KqY4LxX6HJW8bHm0fOxv5JiVi6BIH43KUe07R84kqdgnuhFQ1oFf9tlH2eVn8Zm076ucENNpkSUqO8ZeS/5/eHwmW1nV4gc9nwt79NgpPNpYxCff/X089Lm3495dm3D/oR3CYBdPR7C56OS4zj60okULdFZCY6qedtMqI+m+tD829zjUuDAJ+OikMrFKiIUXtOKVCywpuD0HtmLLmtfxx99+eelYfT77TUdmXVQpXbzyve2m5UK7WS2hsY0M+zjHV10JMarotohQFqxouSivTJ19GDKr8fwqLbYMnYwAYt0OjvXheP003nrxeaVKrf5Sycaeo0pBo61Wtg5R+VGs5NLx7ZAVEgk7dPrYl083+Ybd0N1J3yY+EMrKVa0a5MlKnufRySH85eEfC1eFyazlpx44gcYTs/jOy11YOPPq0nk9S6vAaP+tCNpvzX7JhSdLRs8qLT91IXmwaYqbaDd0x3QRY98039PmHJfzba8h0C4F9uu1pGzAz4zcVM5C8mBVpnooip66qpz8oespS/llRPehK8KwkO0epSNPHjLbrqis1KpNypX4X8nfdNk25Yvk1JVNqmCLeJBs3nyhyvaNTUK4z3rKUn67UrTxwOZ5utYn8lnaPsM2Vix9Psk+ODw+g4H+DU3Klj5f5WvlySaTWXRuY6oexoL1OZBUZaWHXZ9kefojRKqTS/06s0Kf9bMpVC6zUlHKkwpZ6tfRY6ew/6MnWvYsYOsRZTHQ/6frM5XZexaBbx9TjAq0rIrK51Sp0ylyXMqCPvT/CbJzfcmje9ylXl67ZHnqRy76JADg49c9j0q1t2nzbqB5Ixe6fOJyIBYxXZ9IFlE6mlDB2nZEjArRN2Vqo+g+mvqSEsWjskRNLMEQRpBIsesoKZv4BLFgeUq2MVXH6bOv4fD4DP7HL34NALItDiu1ahYYa1powEm9UsHeE9bKFSpYG6dzHg9iWR52GzlDtM3Hg6QbHe9kfLTf1B3Gs6Jsy/chv62bQDbr5Sln3lSdVo7k96PHTqFSq2Lg5kPYUl2NmSf7sefA1iXLtz7fshWhKP+W9yIQWc7sCyT4Sq6UklUsqf+LIfW7HJf+sU0DA5Bt1j06OdSyaTdtDbuktdFkFqxKG+ugU4bIT5QXtn4hm/SRGHBdGpiww5dy1R2bOuM6j2dPV94Q1i7Q7FdtaX+1Fzvfuh+jk0OYnVtsqU+0woxGR2663kzBypzFupj4fkK/3WW+x5ARWNUUQhdfD4FLOckCU+PDhaZbhiwtSmc5q8o6M0EmC4m+s5/Z5snFU0o8V4DsBdKU5nV+gQHZ2pDm8PgMjr/tDuz81UO4dfM6bpCrUqti/douqaLmwZMfKNEXDUJOudJ0Th+TvmLPtd15vozoTDdD1Cc6RoI4Mj+jrq+dVZCiVCfRJ7VV9ejUQY6NTg7h6LFT0rbTx0gmwezcIr4wcBG+80I39k09m53Lyi1qX5NilvSrNwUbaiDZ+ltikSVk3bG+GGKVqwhcXki659soR961sd83177MLNJqL9av7cLOXz2E7QeubVKQ9Ke5faDc7KVS09tQIsQGH7w3WVGyhCzXtu6i5JHdh9gf0rwxuUe2G1rrbvhC3xfetbzPULugel7J7zbPtepa3rHuag8aU3UMf2YLvvSJP8PcP/0gvrL9DNaueS9+8Y7LUbl5fcseBq79oVSwoR5iHeF97MzuAx8dHbou0+tc2qS725MNefZ1zFRq1SaF59ovNoaJTp3sOfTfus+3iZLlXcuTife1AXLuZdUeVG5eDwD4+cp344bVJ/Dcz6/C5W97C1asvCjbKeuG2rXZlxV0djHjHY/eB+vbIsrbN5ZI0PgMMun4QkPK4LtcnewCVxcBHXymf3/6P/09Ft61E8dfWol9U88unS/xrerIValZfjLGBttotu9ofF5ZDIn2R5gOJBmvsuWWJvAyBFSIdpcyjZLrQPcNe63OJ1lsfteFZF3QmQLb/9sHMP1X5/DbP/oihmsbucrVJDOJHI/egk0kEmEpYjbnYoHLyuEd1ymbpJQNvWcZRv/kJ9rWqwpvFqyPfMCy067t8k2Z+ilvWWX5nqHr8VWGiUVPMLHsefmvNHQOLJvnKipnYmQas3OLOHX2bfjGFy7BHX3rlDLroLVUNvkrw5NHnm+6j/ERUxpiUfXJrM082krXQdK07hzehPpLi03LaW1kEyrY9DDqESpoUSZs8zcT8WCTS2tahi83gE0OLy+wpeLoE7dj9E9+ki1oIMtrRV+t5cmr5SIo05TOF7pt9ul4t6nfZwDQFtM+SMo1PnTviSzoHEK58upk/2azA+jjuvLRkCDcwM2HUKn2YnCsD0ePnVoqg/OVBFk9KciV4FKUlZms2/KgE2CKFR1LvFKrYri2EafPvra09eH5wJdO+8g50X2Ti0cscsSOz34q6gGJ/cEMRRnHOC+QRB/3gWnwXDdIqJoxEgW5e9tBHD12CgP9G7ClujoLoPHq4tUj/aJBLIM9FjliRjRNsiknUQyyiLdreb7K5KHaDEUHkXI0mdaT/FbTMni6jlaijak6jh47hS1rXs9cBJVqr7Td5LfkIsiJmF5YIfARJOlUUp+0opP5YpodwzuPVoii38mxPQe24nj9ND520zXYfsteZXmAxzxYuvAykLes7f4AmQRJ2hGX8RRq2SoNb/WUTc5tXnm6Jlan6dhjA2Z0ObzgGbDUf7u3HcTh8Rnc9eBx7DmwNduYmyxSoK1oUo6WBWuT4tCOdHI6Uju1JTTtlqcaE7p7Crs+qyLrmOjCA5//Jb710+tw+uxrmJ1bFO4hG62LoJMGDaET25xIFIXr86aj7HPb7IVGZ0qRtwVgcjwUPoJUMZFXkCVxgbL0sa8gmMsYM82Lpd0sg2N9WL+2C3sObMX+R3e21E3+XYiCtVUkPgcP64dRHc+LPJYFkv+Hfhh5kdlEWIrKXRaNJ9nOWSKFKcomEGUIiMaxqG4V9DMCILNSSQ4ssLTgYGJkGqfPvoY1l/2s5ZrCXQSmEUCbsjuZovug6PoTFyD3wtc30VzurUk8xySTQFeuSq2afbpbVI+qPhLcolO2xvtn8eKbH8CVq36I69//TLangfSz3SExjQDalO2CzRQmL4p0sei2MynXC4QcGzplE4VAlKuuS0x0nsu9FVmisnpk59O/6ZY7MTItncFVqr3Stjfq81lfDvRvQKM+j6/XfwNXvfnnOPXyewFc6Otog1ydRDtbe+3cttiIoa9NZAglr0257DWqjx/yrN3BsT6M98/i6/XfyJS4sQ/WJk/O1heSN0UFCIp+KFh89kNsbWtnZH2tZelq3nfyPLusvJLV65prS9whvHJl5dC+ZHZTF/q60cmhrA7yN3G/vPjmB/Dx6543y4MtAtu3m4+3YgyWQCJeUtzAHF3/aJ594OKTFslKfLRktVemYHUb1+4DIZHIiyKeJVWdnfp8uwbu2GsHx/pw6+Z1+P8BE0QwpfZrys8AAAAASUVORK5CYII=" y="-29"/>
+   <g id="matplotlib.axis_1">
+    <g id="xtick_1">
+     <g id="line2d_1">
+      <defs>
+       <path d="M 0 0 
+L 0 3.5 
+" id="m8e53a56d50" style="stroke:#000000;stroke-width:0.8;"/>
+      </defs>
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="57.6" xlink:href="#m8e53a56d50" y="374.4"/>
+      </g>
+     </g>
+     <g id="text_1">
+      <!-- 0.00  -->
+      <defs>
+       <path d="M 31.78125 66.40625 
+Q 24.171875 66.40625 20.328125 58.90625 
+Q 16.5 51.421875 16.5 36.375 
+Q 16.5 21.390625 20.328125 13.890625 
+Q 24.171875 6.390625 31.78125 6.390625 
+Q 39.453125 6.390625 43.28125 13.890625 
+Q 47.125 21.390625 47.125 36.375 
+Q 47.125 51.421875 43.28125 58.90625 
+Q 39.453125 66.40625 31.78125 66.40625 
+z
+M 31.78125 74.21875 
+Q 44.046875 74.21875 50.515625 64.515625 
+Q 56.984375 54.828125 56.984375 36.375 
+Q 56.984375 17.96875 50.515625 8.265625 
+Q 44.046875 -1.421875 31.78125 -1.421875 
+Q 19.53125 -1.421875 13.0625 8.265625 
+Q 6.59375 17.96875 6.59375 36.375 
+Q 6.59375 54.828125 13.0625 64.515625 
+Q 19.53125 74.21875 31.78125 74.21875 
+z
+" id="DejaVuSans-30"/>
+       <path d="M 10.6875 12.40625 
+L 21 12.40625 
+L 21 0 
+L 10.6875 0 
+z
+" id="DejaVuSans-2e"/>
+       <path id="DejaVuSans-20"/>
+      </defs>
+      <g transform="translate(51.731889 400.862508)rotate(-45)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-30"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-2e"/>
+       <use x="95.410156" xlink:href="#DejaVuSans-30"/>
+       <use x="159.033203" xlink:href="#DejaVuSans-30"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="xtick_2">
+     <g id="line2d_2">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="126.800955" xlink:href="#m8e53a56d50" y="374.4"/>
+      </g>
+     </g>
+     <g id="text_2">
+      <!-- 50.00  -->
+      <defs>
+       <path d="M 10.796875 72.90625 
+L 49.515625 72.90625 
+L 49.515625 64.59375 
+L 19.828125 64.59375 
+L 19.828125 46.734375 
+Q 21.96875 47.46875 24.109375 47.828125 
+Q 26.265625 48.1875 28.421875 48.1875 
+Q 40.625 48.1875 47.75 41.5 
+Q 54.890625 34.8125 54.890625 23.390625 
+Q 54.890625 11.625 47.5625 5.09375 
+Q 40.234375 -1.421875 26.90625 -1.421875 
+Q 22.3125 -1.421875 17.546875 -0.640625 
+Q 12.796875 0.140625 7.71875 1.703125 
+L 7.71875 11.625 
+Q 12.109375 9.234375 16.796875 8.0625 
+Q 21.484375 6.890625 26.703125 6.890625 
+Q 35.15625 6.890625 40.078125 11.328125 
+Q 45.015625 15.765625 45.015625 23.390625 
+Q 45.015625 31 40.078125 35.4375 
+Q 35.15625 39.890625 26.703125 39.890625 
+Q 22.75 39.890625 18.8125 39.015625 
+Q 14.890625 38.140625 10.796875 36.28125 
+z
+" id="DejaVuSans-35"/>
+      </defs>
+      <g transform="translate(119.059024 404.610147)rotate(-45)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-35"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-30"/>
+       <use x="127.246094" xlink:href="#DejaVuSans-2e"/>
+       <use x="159.033203" xlink:href="#DejaVuSans-30"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-30"/>
+       <use x="286.279297" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="xtick_3">
+     <g id="line2d_3">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="196.001911" xlink:href="#m8e53a56d50" y="374.4"/>
+      </g>
+     </g>
+     <g id="text_3">
+      <!-- 100.00  -->
+      <defs>
+       <path d="M 12.40625 8.296875 
+L 28.515625 8.296875 
+L 28.515625 63.921875 
+L 10.984375 60.40625 
+L 10.984375 69.390625 
+L 28.421875 72.90625 
+L 38.28125 72.90625 
+L 38.28125 8.296875 
+L 54.390625 8.296875 
+L 54.390625 0 
+L 12.40625 0 
+z
+" id="DejaVuSans-31"/>
+      </defs>
+      <g transform="translate(186.38616 408.357786)rotate(-45)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-31"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-30"/>
+       <use x="127.246094" xlink:href="#DejaVuSans-30"/>
+       <use x="190.869141" xlink:href="#DejaVuSans-2e"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-30"/>
+       <use x="286.279297" xlink:href="#DejaVuSans-30"/>
+       <use x="349.902344" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="xtick_4">
+     <g id="line2d_4">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="265.202866" xlink:href="#m8e53a56d50" y="374.4"/>
+      </g>
+     </g>
+     <g id="text_4">
+      <!-- 150.00  -->
+      <g transform="translate(255.587115 408.357786)rotate(-45)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-31"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-35"/>
+       <use x="127.246094" xlink:href="#DejaVuSans-30"/>
+       <use x="190.869141" xlink:href="#DejaVuSans-2e"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-30"/>
+       <use x="286.279297" xlink:href="#DejaVuSans-30"/>
+       <use x="349.902344" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="xtick_5">
+     <g id="line2d_5">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="334.403821" xlink:href="#m8e53a56d50" y="374.4"/>
+      </g>
+     </g>
+     <g id="text_5">
+      <!-- 200.00  -->
+      <defs>
+       <path d="M 19.1875 8.296875 
+L 53.609375 8.296875 
+L 53.609375 0 
+L 7.328125 0 
+L 7.328125 8.296875 
+Q 12.9375 14.109375 22.625 23.890625 
+Q 32.328125 33.6875 34.8125 36.53125 
+Q 39.546875 41.84375 41.421875 45.53125 
+Q 43.3125 49.21875 43.3125 52.78125 
+Q 43.3125 58.59375 39.234375 62.25 
+Q 35.15625 65.921875 28.609375 65.921875 
+Q 23.96875 65.921875 18.8125 64.3125 
+Q 13.671875 62.703125 7.8125 59.421875 
+L 7.8125 69.390625 
+Q 13.765625 71.78125 18.9375 73 
+Q 24.125 74.21875 28.421875 74.21875 
+Q 39.75 74.21875 46.484375 68.546875 
+Q 53.21875 62.890625 53.21875 53.421875 
+Q 53.21875 48.921875 51.53125 44.890625 
+Q 49.859375 40.875 45.40625 35.40625 
+Q 44.1875 33.984375 37.640625 27.21875 
+Q 31.109375 20.453125 19.1875 8.296875 
+z
+" id="DejaVuSans-32"/>
+      </defs>
+      <g transform="translate(324.78807 408.357786)rotate(-45)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-32"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-30"/>
+       <use x="127.246094" xlink:href="#DejaVuSans-30"/>
+       <use x="190.869141" xlink:href="#DejaVuSans-2e"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-30"/>
+       <use x="286.279297" xlink:href="#DejaVuSans-30"/>
+       <use x="349.902344" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="text_6">
+     <!-- chr1 -->
+     <defs>
+      <path d="M 48.78125 52.59375 
+L 48.78125 44.1875 
+Q 44.96875 46.296875 41.140625 47.34375 
+Q 37.3125 48.390625 33.40625 48.390625 
+Q 24.65625 48.390625 19.8125 42.84375 
+Q 14.984375 37.3125 14.984375 27.296875 
+Q 14.984375 17.28125 19.8125 11.734375 
+Q 24.65625 6.203125 33.40625 6.203125 
+Q 37.3125 6.203125 41.140625 7.25 
+Q 44.96875 8.296875 48.78125 10.40625 
+L 48.78125 2.09375 
+Q 45.015625 0.34375 40.984375 -0.53125 
+Q 36.96875 -1.421875 32.421875 -1.421875 
+Q 20.0625 -1.421875 12.78125 6.34375 
+Q 5.515625 14.109375 5.515625 27.296875 
+Q 5.515625 40.671875 12.859375 48.328125 
+Q 20.21875 56 33.015625 56 
+Q 37.15625 56 41.109375 55.140625 
+Q 45.0625 54.296875 48.78125 52.59375 
+z
+" id="DejaVuSans-63"/>
+      <path d="M 54.890625 33.015625 
+L 54.890625 0 
+L 45.90625 0 
+L 45.90625 32.71875 
+Q 45.90625 40.484375 42.875 44.328125 
+Q 39.84375 48.1875 33.796875 48.1875 
+Q 26.515625 48.1875 22.3125 43.546875 
+Q 18.109375 38.921875 18.109375 30.90625 
+L 18.109375 0 
+L 9.078125 0 
+L 9.078125 75.984375 
+L 18.109375 75.984375 
+L 18.109375 46.1875 
+Q 21.34375 51.125 25.703125 53.5625 
+Q 30.078125 56 35.796875 56 
+Q 45.21875 56 50.046875 50.171875 
+Q 54.890625 44.34375 54.890625 33.015625 
+z
+" id="DejaVuSans-68"/>
+      <path d="M 41.109375 46.296875 
+Q 39.59375 47.171875 37.8125 47.578125 
+Q 36.03125 48 33.890625 48 
+Q 26.265625 48 22.1875 43.046875 
+Q 18.109375 38.09375 18.109375 28.8125 
+L 18.109375 0 
+L 9.078125 0 
+L 9.078125 54.6875 
+L 18.109375 54.6875 
+L 18.109375 46.1875 
+Q 20.953125 51.171875 25.484375 53.578125 
+Q 30.03125 56 36.53125 56 
+Q 37.453125 56 38.578125 55.875 
+Q 39.703125 55.765625 41.0625 55.515625 
+z
+" id="DejaVuSans-72"/>
+     </defs>
+     <g transform="translate(218.894093 421.181201)scale(0.1 -0.1)">
+      <use xlink:href="#DejaVuSans-63"/>
+      <use x="54.980469" xlink:href="#DejaVuSans-68"/>
+      <use x="118.359375" xlink:href="#DejaVuSans-72"/>
+      <use x="159.472656" xlink:href="#DejaVuSans-31"/>
+     </g>
+    </g>
+   </g>
+   <g id="matplotlib.axis_2">
+    <g id="ytick_1">
+     <g id="line2d_6">
+      <defs>
+       <path d="M 0 0 
+L -3.5 0 
+" id="m075855bf55" style="stroke:#000000;stroke-width:0.8;"/>
+      </defs>
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="57.6" xlink:href="#m075855bf55" y="374.4"/>
+      </g>
+     </g>
+     <g id="text_7">
+      <!-- 0.00  -->
+      <g transform="translate(29.405356 377.564749)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-30"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-2e"/>
+       <use x="95.410156" xlink:href="#DejaVuSans-30"/>
+       <use x="159.033203" xlink:href="#DejaVuSans-30"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_2">
+     <g id="line2d_7">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="57.6" xlink:href="#m075855bf55" y="305.058106"/>
+      </g>
+     </g>
+     <g id="text_8">
+      <!-- 50.00  -->
+      <g transform="translate(24.105394 308.222855)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-35"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-30"/>
+       <use x="127.246094" xlink:href="#DejaVuSans-2e"/>
+       <use x="159.033203" xlink:href="#DejaVuSans-30"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-30"/>
+       <use x="286.279297" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_3">
+     <g id="line2d_8">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="57.6" xlink:href="#m075855bf55" y="235.716212"/>
+      </g>
+     </g>
+     <g id="text_9">
+      <!-- 100.00  -->
+      <g transform="translate(18.805431 238.880961)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-31"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-30"/>
+       <use x="127.246094" xlink:href="#DejaVuSans-30"/>
+       <use x="190.869141" xlink:href="#DejaVuSans-2e"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-30"/>
+       <use x="286.279297" xlink:href="#DejaVuSans-30"/>
+       <use x="349.902344" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_4">
+     <g id="line2d_9">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="57.6" xlink:href="#m075855bf55" y="166.374318"/>
+      </g>
+     </g>
+     <g id="text_10">
+      <!-- 150.00  -->
+      <g transform="translate(18.805431 169.539067)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-31"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-35"/>
+       <use x="127.246094" xlink:href="#DejaVuSans-30"/>
+       <use x="190.869141" xlink:href="#DejaVuSans-2e"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-30"/>
+       <use x="286.279297" xlink:href="#DejaVuSans-30"/>
+       <use x="349.902344" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_5">
+     <g id="line2d_10">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="57.6" xlink:href="#m075855bf55" y="97.032424"/>
+      </g>
+     </g>
+     <g id="text_11">
+      <!-- 200.00  -->
+      <g transform="translate(18.805431 100.197173)scale(0.0833 -0.0833)">
+       <use xlink:href="#DejaVuSans-32"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-30"/>
+       <use x="127.246094" xlink:href="#DejaVuSans-30"/>
+       <use x="190.869141" xlink:href="#DejaVuSans-2e"/>
+       <use x="222.65625" xlink:href="#DejaVuSans-30"/>
+       <use x="286.279297" xlink:href="#DejaVuSans-30"/>
+       <use x="349.902344" xlink:href="#DejaVuSans-20"/>
+      </g>
+     </g>
+    </g>
+    <g id="text_12">
+     <!-- chr1 -->
+     <g transform="translate(12.725744 212.754688)rotate(-90)scale(0.1 -0.1)">
+      <use xlink:href="#DejaVuSans-63"/>
+      <use x="54.980469" xlink:href="#DejaVuSans-68"/>
+      <use x="118.359375" xlink:href="#DejaVuSans-72"/>
+      <use x="159.472656" xlink:href="#DejaVuSans-31"/>
+     </g>
+    </g>
+   </g>
+   <g id="patch_3">
+    <path d="M 57.6 374.4 
+L 57.6 28.8 
+" style="fill:none;stroke:#000000;stroke-linecap:square;stroke-linejoin:miter;stroke-width:0.8;"/>
+   </g>
+   <g id="patch_4">
+    <path d="M 402.497561 374.4 
+L 402.497561 28.8 
+" style="fill:none;stroke:#000000;stroke-linecap:square;stroke-linejoin:miter;stroke-width:0.8;"/>
+   </g>
+   <g id="patch_5">
+    <path d="M 57.6 374.4 
+L 402.497561 374.4 
+" style="fill:none;stroke:#000000;stroke-linecap:square;stroke-linejoin:miter;stroke-width:0.8;"/>
+   </g>
+   <g id="patch_6">
+    <path d="M 57.6 28.8 
+L 402.497561 28.8 
+" style="fill:none;stroke:#000000;stroke-linecap:square;stroke-linejoin:miter;stroke-width:0.8;"/>
+   </g>
+   <g id="text_13">
+    <!-- SRR027956 -->
+    <defs>
+     <path d="M 53.515625 70.515625 
+L 53.515625 60.890625 
+Q 47.90625 63.578125 42.921875 64.890625 
+Q 37.9375 66.21875 33.296875 66.21875 
+Q 25.25 66.21875 20.875 63.09375 
+Q 16.5 59.96875 16.5 54.203125 
+Q 16.5 49.359375 19.40625 46.890625 
+Q 22.3125 44.4375 30.421875 42.921875 
+L 36.375 41.703125 
+Q 47.40625 39.59375 52.65625 34.296875 
+Q 57.90625 29 57.90625 20.125 
+Q 57.90625 9.515625 50.796875 4.046875 
+Q 43.703125 -1.421875 29.984375 -1.421875 
+Q 24.8125 -1.421875 18.96875 -0.25 
+Q 13.140625 0.921875 6.890625 3.21875 
+L 6.890625 13.375 
+Q 12.890625 10.015625 18.65625 8.296875 
+Q 24.421875 6.59375 29.984375 6.59375 
+Q 38.421875 6.59375 43.015625 9.90625 
+Q 47.609375 13.234375 47.609375 19.390625 
+Q 47.609375 24.75 44.3125 27.78125 
+Q 41.015625 30.8125 33.5 32.328125 
+L 27.484375 33.5 
+Q 16.453125 35.6875 11.515625 40.375 
+Q 6.59375 45.0625 6.59375 53.421875 
+Q 6.59375 63.09375 13.40625 68.65625 
+Q 20.21875 74.21875 32.171875 74.21875 
+Q 37.3125 74.21875 42.625 73.28125 
+Q 47.953125 72.359375 53.515625 70.515625 
+z
+" id="DejaVuSans-53"/>
+     <path d="M 44.390625 34.1875 
+Q 47.5625 33.109375 50.5625 29.59375 
+Q 53.5625 26.078125 56.59375 19.921875 
+L 66.609375 0 
+L 56 0 
+L 46.6875 18.703125 
+Q 43.0625 26.03125 39.671875 28.421875 
+Q 36.28125 30.8125 30.421875 30.8125 
+L 19.671875 30.8125 
+L 19.671875 0 
+L 9.8125 0 
+L 9.8125 72.90625 
+L 32.078125 72.90625 
+Q 44.578125 72.90625 50.734375 67.671875 
+Q 56.890625 62.453125 56.890625 51.90625 
+Q 56.890625 45.015625 53.6875 40.46875 
+Q 50.484375 35.9375 44.390625 34.1875 
+z
+M 19.671875 64.796875 
+L 19.671875 38.921875 
+L 32.078125 38.921875 
+Q 39.203125 38.921875 42.84375 42.21875 
+Q 46.484375 45.515625 46.484375 51.90625 
+Q 46.484375 58.296875 42.84375 61.546875 
+Q 39.203125 64.796875 32.078125 64.796875 
+z
+" id="DejaVuSans-52"/>
+     <path d="M 8.203125 72.90625 
+L 55.078125 72.90625 
+L 55.078125 68.703125 
+L 28.609375 0 
+L 18.3125 0 
+L 43.21875 64.59375 
+L 8.203125 64.59375 
+z
+" id="DejaVuSans-37"/>
+     <path d="M 10.984375 1.515625 
+L 10.984375 10.5 
+Q 14.703125 8.734375 18.5 7.8125 
+Q 22.3125 6.890625 25.984375 6.890625 
+Q 35.75 6.890625 40.890625 13.453125 
+Q 46.046875 20.015625 46.78125 33.40625 
+Q 43.953125 29.203125 39.59375 26.953125 
+Q 35.25 24.703125 29.984375 24.703125 
+Q 19.046875 24.703125 12.671875 31.3125 
+Q 6.296875 37.9375 6.296875 49.421875 
+Q 6.296875 60.640625 12.9375 67.421875 
+Q 19.578125 74.21875 30.609375 74.21875 
+Q 43.265625 74.21875 49.921875 64.515625 
+Q 56.59375 54.828125 56.59375 36.375 
+Q 56.59375 19.140625 48.40625 8.859375 
+Q 40.234375 -1.421875 26.421875 -1.421875 
+Q 22.703125 -1.421875 18.890625 -0.6875 
+Q 15.09375 0.046875 10.984375 1.515625 
+z
+M 30.609375 32.421875 
+Q 37.25 32.421875 41.125 36.953125 
+Q 45.015625 41.5 45.015625 49.421875 
+Q 45.015625 57.28125 41.125 61.84375 
+Q 37.25 66.40625 30.609375 66.40625 
+Q 23.96875 66.40625 20.09375 61.84375 
+Q 16.21875 57.28125 16.21875 49.421875 
+Q 16.21875 41.5 20.09375 36.953125 
+Q 23.96875 32.421875 30.609375 32.421875 
+z
+" id="DejaVuSans-39"/>
+     <path d="M 33.015625 40.375 
+Q 26.375 40.375 22.484375 35.828125 
+Q 18.609375 31.296875 18.609375 23.390625 
+Q 18.609375 15.53125 22.484375 10.953125 
+Q 26.375 6.390625 33.015625 6.390625 
+Q 39.65625 6.390625 43.53125 10.953125 
+Q 47.40625 15.53125 47.40625 23.390625 
+Q 47.40625 31.296875 43.53125 35.828125 
+Q 39.65625 40.375 33.015625 40.375 
+z
+M 52.59375 71.296875 
+L 52.59375 62.3125 
+Q 48.875 64.0625 45.09375 64.984375 
+Q 41.3125 65.921875 37.59375 65.921875 
+Q 27.828125 65.921875 22.671875 59.328125 
+Q 17.53125 52.734375 16.796875 39.40625 
+Q 19.671875 43.65625 24.015625 45.921875 
+Q 28.375 48.1875 33.59375 48.1875 
+Q 44.578125 48.1875 50.953125 41.515625 
+Q 57.328125 34.859375 57.328125 23.390625 
+Q 57.328125 12.15625 50.6875 5.359375 
+Q 44.046875 -1.421875 33.015625 -1.421875 
+Q 20.359375 -1.421875 13.671875 8.265625 
+Q 6.984375 17.96875 6.984375 36.375 
+Q 6.984375 53.65625 15.1875 63.9375 
+Q 23.390625 74.21875 37.203125 74.21875 
+Q 40.921875 74.21875 44.703125 73.484375 
+Q 48.484375 72.75 52.59375 71.296875 
+z
+" id="DejaVuSans-36"/>
+    </defs>
+    <g transform="translate(194.996593 22.8)scale(0.12 -0.12)">
+     <use xlink:href="#DejaVuSans-53"/>
+     <use x="63.476562" xlink:href="#DejaVuSans-52"/>
+     <use x="132.958984" xlink:href="#DejaVuSans-52"/>
+     <use x="202.441406" xlink:href="#DejaVuSans-30"/>
+     <use x="266.064453" xlink:href="#DejaVuSans-32"/>
+     <use x="329.6875" xlink:href="#DejaVuSans-37"/>
+     <use x="393.310547" xlink:href="#DejaVuSans-39"/>
+     <use x="456.933594" xlink:href="#DejaVuSans-35"/>
+     <use x="520.556641" xlink:href="#DejaVuSans-36"/>
+    </g>
+   </g>
+  </g>
+  <g id="axes_2">
+   <g id="patch_7">
+    <path clip-path="url(#pda3c0c3bdd)" d="M 408.977561 374.4 
+L 408.977561 373.05 
+L 408.977561 30.15 
+L 408.977561 28.8 
+L 417.6 28.8 
+L 417.6 30.15 
+L 417.6 373.05 
+L 417.6 374.4 
+z
+" style="fill:#ffffff;stroke:#ffffff;stroke-linejoin:miter;stroke-width:0.01;"/>
+   </g>
+   <image height="345" id="image0c8330bae8" transform="scale(1 -1)translate(0 -345)" width="9" x="409" xlink:href="data:image/png;base64,
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" y="-29"/>
+   <g id="matplotlib.axis_3"/>
+   <g id="matplotlib.axis_4">
+    <g id="ytick_6">
+     <g id="line2d_11">
+      <defs>
+       <path d="M 0 0 
+L 3.5 0 
+" id="m495cf070a1" style="stroke:#000000;stroke-width:0.8;"/>
+      </defs>
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="417.6" xlink:href="#m495cf070a1" y="374.4"/>
+      </g>
+     </g>
+     <g id="text_14">
+      <!-- 1 -->
+      <g transform="translate(424.6 378.199219)scale(0.1 -0.1)">
+       <use xlink:href="#DejaVuSans-31"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_7">
+     <g id="line2d_12">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="417.6" xlink:href="#m495cf070a1" y="327.082041"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_8">
+     <g id="line2d_13">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="417.6" xlink:href="#m495cf070a1" y="264.531101"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_9">
+     <g id="line2d_14">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="417.6" xlink:href="#m495cf070a1" y="217.213142"/>
+      </g>
+     </g>
+     <g id="text_15">
+      <!-- 10 -->
+      <g transform="translate(424.6 221.01236)scale(0.1 -0.1)">
+       <use xlink:href="#DejaVuSans-31"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-30"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_10">
+     <g id="line2d_15">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="417.6" xlink:href="#m495cf070a1" y="169.895182"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_11">
+     <g id="line2d_16">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="417.6" xlink:href="#m495cf070a1" y="107.344243"/>
+      </g>
+     </g>
+    </g>
+    <g id="ytick_12">
+     <g id="line2d_17">
+      <g>
+       <use style="stroke:#000000;stroke-width:0.8;" x="417.6" xlink:href="#m495cf070a1" y="60.026283"/>
+      </g>
+     </g>
+     <g id="text_16">
+      <!-- 100 -->
+      <g transform="translate(424.6 63.825502)scale(0.1 -0.1)">
+       <use xlink:href="#DejaVuSans-31"/>
+       <use x="63.623047" xlink:href="#DejaVuSans-30"/>
+       <use x="127.246094" xlink:href="#DejaVuSans-30"/>
+      </g>
+     </g>
+    </g>
+   </g>
+   <g id="patch_8">
+    <path d="M 408.977561 374.4 
+L 408.977561 373.05 
+L 408.977561 30.15 
+L 408.977561 28.8 
+L 417.6 28.8 
+L 417.6 30.15 
+L 417.6 373.05 
+L 417.6 374.4 
+z
+" style="fill:none;stroke:#000000;stroke-linejoin:miter;stroke-width:0.8;"/>
+   </g>
+  </g>
+ </g>
+ <defs>
+  <clipPath id="pda3c0c3bdd">
+   <rect height="345.6" width="8.622439" x="408.977561" y="28.8"/>
+  </clipPath>
+ </defs>
+</svg>
Binary file static/images/SRR0279XX_perChr_eigenvector1.png has changed
Binary file static/images/diagnostic_plot.png has changed
Binary file static/images/hicCorrelate_pearson.png has changed
Binary file static/images/hicCorrelate_pearson_scatter.png has changed
Binary file static/images/hicCorrelate_spearman.png has changed
Binary file static/images/hicCorrelate_spearman_scatter.png has changed
Binary file static/images/hicPlotDistVsCounts_result1.png has changed
Binary file static/images/hicPlotDistVsCounts_result2.png has changed
Binary file static/images/hicQC.png has changed
Binary file static/images/master_TADs_plot.png has changed
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/static/images/z-score.svg	Sat Dec 16 16:32:17 2017 -0500
@@ -0,0 +1,27 @@
+<?xml version="1.0" standalone="no"?>
+<!DOCTYPE svg PUBLIC "-//W3C//DTD SVG 1.1//EN" "http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd">
+<svg xmlns:xlink="http://www.w3.org/1999/xlink" width="10.647ex" height="4.843ex" style="vertical-align: -1.838ex;" viewBox="0 -1293.7 4584 2085" xmlns="http://www.w3.org/2000/svg">
+<defs>
+<path stroke-width="10" id="E1-MJMATHI-7A" d="M347 338Q337 338 294 349T231 360Q211 360 197 356T174 346T162 335T155 324L153 320Q150 317 138 317Q117 317 117 325Q117 330 120 339Q133 378 163 406T229 440Q241 442 246 442Q271 442 291 425T329 392T367 375Q389 375 411 408T434 441Q435 442 449 442H462Q468 436 468 434Q468 430 463 420T449 399T432 377T418 358L411 349Q368 298 275 214T160 106L148 94L163 93Q185 93 227 82T290 71Q328 71 360 90T402 140Q406 149 409 151T424 153Q443 153 443 143Q443 138 442 134Q425 72 376 31T278 -11Q252 -11 232 6T193 40T155 57Q111 57 76 -3Q70 -11 59 -11H54H41Q35 -5 35 -2Q35 13 93 84Q132 129 225 214T340 322Q352 338 347 338Z"></path>
+<path stroke-width="10" id="E1-MJMAIN-3D" d="M56 347Q56 360 70 367H707Q722 359 722 347Q722 336 708 328L390 327H72Q56 332 56 347ZM56 153Q56 168 72 173H708Q722 163 722 153Q722 140 707 133H70Q56 140 56 153Z"></path>
+<path stroke-width="10" id="E1-MJMATHI-78" d="M52 289Q59 331 106 386T222 442Q257 442 286 424T329 379Q371 442 430 442Q467 442 494 420T522 361Q522 332 508 314T481 292T458 288Q439 288 427 299T415 328Q415 374 465 391Q454 404 425 404Q412 404 406 402Q368 386 350 336Q290 115 290 78Q290 50 306 38T341 26Q378 26 414 59T463 140Q466 150 469 151T485 153H489Q504 153 504 145Q504 144 502 134Q486 77 440 33T333 -11Q263 -11 227 52Q186 -10 133 -10H127Q78 -10 57 16T35 71Q35 103 54 123T99 143Q142 143 142 101Q142 81 130 66T107 46T94 41L91 40Q91 39 97 36T113 29T132 26Q168 26 194 71Q203 87 217 139T245 247T261 313Q266 340 266 352Q266 380 251 392T217 404Q177 404 142 372T93 290Q91 281 88 280T72 278H58Q52 284 52 289Z"></path>
+<path stroke-width="10" id="E1-MJMAIN-2212" d="M84 237T84 250T98 270H679Q694 262 694 250T679 230H98Q84 237 84 250Z"></path>
+<path stroke-width="10" id="E1-MJMATHI-3BC" d="M58 -216Q44 -216 34 -208T23 -186Q23 -176 96 116T173 414Q186 442 219 442Q231 441 239 435T249 423T251 413Q251 401 220 279T187 142Q185 131 185 107V99Q185 26 252 26Q261 26 270 27T287 31T302 38T315 45T327 55T338 65T348 77T356 88T365 100L372 110L408 253Q444 395 448 404Q461 431 491 431Q504 431 512 424T523 412T525 402L449 84Q448 79 448 68Q448 43 455 35T476 26Q485 27 496 35Q517 55 537 131Q543 151 547 152Q549 153 557 153H561Q580 153 580 144Q580 138 575 117T555 63T523 13Q510 0 491 -8Q483 -10 467 -10Q446 -10 429 -4T402 11T385 29T376 44T374 51L368 45Q362 39 350 30T324 12T288 -4T246 -11Q199 -11 153 12L129 -85Q108 -167 104 -180T92 -202Q76 -216 58 -216Z"></path>
+<path stroke-width="10" id="E1-MJMATHI-3C3" d="M184 -11Q116 -11 74 34T31 147Q31 247 104 333T274 430Q275 431 414 431H552Q553 430 555 429T559 427T562 425T565 422T567 420T569 416T570 412T571 407T572 401Q572 357 507 357Q500 357 490 357T476 358H416L421 348Q439 310 439 263Q439 153 359 71T184 -11ZM361 278Q361 358 276 358Q152 358 115 184Q114 180 114 178Q106 141 106 117Q106 67 131 47T188 26Q242 26 287 73Q316 103 334 153T356 233T361 278Z"></path>
+</defs>
+<g stroke="currentColor" fill="currentColor" stroke-width="0" transform="matrix(1 0 0 -1 0 0)">
+ <use xlink:href="#E1-MJMATHI-7A" x="0" y="0"></use>
+ <use xlink:href="#E1-MJMAIN-3D" x="750" y="0"></use>
+<g transform="translate(1811,0)">
+<g transform="translate(120,0)">
+<rect stroke="none" width="2532" height="60" x="0" y="220"></rect>
+<g transform="translate(60,745)">
+ <use xlink:href="#E1-MJMATHI-78" x="0" y="0"></use>
+ <use xlink:href="#E1-MJMAIN-2212" x="799" y="0"></use>
+ <use xlink:href="#E1-MJMATHI-3BC" x="1804" y="0"></use>
+</g>
+ <use xlink:href="#E1-MJMATHI-3C3" x="977" y="-686"></use>
+</g>
+</g>
+</g>
+</svg>
\ No newline at end of file