Mercurial > repos > bgruening > pharmcat
diff test-data/test_1.pheno.json @ 1:891283e0ee89 draft default tip
"planemo upload for repository https://github.com/bgruening/galaxytools/tree/master/tools/pharmcat commit dddf99b20ed9b07334505917f362785e3dace3b9"
| author | bgruening |
|---|---|
| date | Thu, 05 May 2022 20:27:17 +0000 |
| parents | d67642a21a1d |
| children |
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--- a/test-data/test_1.pheno.json Fri Jan 28 21:18:23 2022 +0000 +++ b/test-data/test_1.pheno.json Thu May 05 20:27:17 2022 +0000 @@ -1,5 +1,90 @@ [ { + "geneSymbol": "ABCG2", + "chr": "chr4", + "phased": true, + "callSource": "MATCHER", + "uncalledHaplotypes": [ + "rs2231142 reference (G)", + "rs2231142 variant (T)" + ], + "messages": [], + "relatedDrugs": [ + { + "name": "rosuvastatin", + "guidelineId": "RxNorm:301542" + } + ], + "matcherDiplotypes": [ + { + "allele1": { + "gene": "ABCG2", + "name": "Unknown", + "function": "Unassigned function", + "reference": false + }, + "allele2": { + "gene": "ABCG2", + "name": "Unknown", + "function": "Unassigned function", + "reference": false + }, + "gene": "ABCG2", + "phenotypes": [ + "No Result" + ], + "variant": null, + "lookupKey": [ + "No Result" + ], + "label": "Unknown/Unknown" + } + ], + "diplotypes": [ + { + "allele1": { + "gene": "ABCG2", + "name": "Unknown", + "function": "Unassigned function", + "reference": false + }, + "allele2": { + "gene": "ABCG2", + "name": "Unknown", + "function": "Unassigned function", + "reference": false + }, + "gene": "ABCG2", + "phenotypes": [ + "No Result" + ], + "variant": null, + "lookupKey": [ + "No Result" + ], + "label": "Unknown/Unknown" + } + ], + "variants": [ + { + "gene": "ABCG2", + "chromosome": "chr4", + "position": 88131171, + "dbSnpId": "rs2231142", + "call": null, + "alleles": [ + "rs2231142 variant (T)" + ], + "phased": false, + "wildtypeAllele": "G", + "mismatch": false, + "warnings": [] + } + ], + "variantsOfInterest": [], + "highlightedVariants": [] + }, + { "geneSymbol": "CACNA1S", "chr": "chr1", "phased": true, @@ -51,9 +136,13 @@ "reference": true }, "gene": "CACNA1S", - "phenotype": "Uncertain Susceptibility", + "phenotypes": [ + "Uncertain Susceptibility" + ], "variant": null, - "lookupKey": "Uncertain Susceptibility", + "lookupKey": [ + "Uncertain Susceptibility" + ], "label": "Reference/Reference" } ], @@ -72,9 +161,13 @@ "reference": true }, "gene": "CACNA1S", - "phenotype": "Uncertain Susceptibility", + "phenotypes": [ + "Uncertain Susceptibility" + ], "variant": null, - "lookupKey": "Uncertain Susceptibility", + "lookupKey": [ + "Uncertain Susceptibility" + ], "label": "Reference/Reference" } ], @@ -90,7 +183,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CACNA1S", @@ -103,7 +197,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -137,9 +232,13 @@ "reference": true }, "gene": "CFTR", - "phenotype": "ivacaftor non-responsive in CF patients", + "phenotypes": [ + "ivacaftor non-responsive in CF patients" + ], "variant": null, - "lookupKey": "ivacaftor non-responsive in CF patients", + "lookupKey": [ + "ivacaftor non-responsive in CF patients" + ], "label": "No CPIC variants found" } ], @@ -158,9 +257,13 @@ "reference": true }, "gene": "CFTR", - "phenotype": "ivacaftor non-responsive in CF patients", + "phenotypes": [ + "ivacaftor non-responsive in CF patients" + ], "variant": null, - "lookupKey": "ivacaftor non-responsive in CF patients", + "lookupKey": [ + "ivacaftor non-responsive in CF patients" + ], "label": "No CPIC variants found" } ], @@ -176,7 +279,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -189,7 +293,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -202,7 +307,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -215,7 +321,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -228,7 +335,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -241,7 +349,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -254,7 +363,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -267,7 +377,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -280,7 +391,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -293,7 +405,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -306,7 +419,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -319,7 +433,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -332,7 +447,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -345,7 +461,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -358,7 +475,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -371,7 +489,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -384,7 +503,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -397,7 +517,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -410,7 +531,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -423,7 +545,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -436,7 +559,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -449,7 +573,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -462,7 +587,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -475,7 +601,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -488,7 +615,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -501,7 +629,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -514,7 +643,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -527,7 +657,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -540,7 +671,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -553,7 +685,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -566,7 +699,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -579,7 +713,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -592,7 +727,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -605,7 +741,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -618,7 +755,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -631,7 +769,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -644,7 +783,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -657,7 +797,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CFTR", @@ -670,7 +811,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -704,9 +846,13 @@ "reference": true }, "gene": "CYP2B6", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -725,9 +871,13 @@ "reference": true }, "gene": "CYP2B6", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -746,7 +896,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -759,7 +910,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -773,7 +925,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -786,7 +939,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -799,7 +953,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -812,7 +967,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -825,7 +981,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -838,7 +995,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -851,7 +1009,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -864,7 +1023,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -877,7 +1037,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -890,7 +1051,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -904,7 +1066,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -917,7 +1080,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -930,7 +1094,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -943,7 +1108,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -956,7 +1122,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -979,7 +1146,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -992,7 +1160,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1006,7 +1175,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1019,7 +1189,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1043,7 +1214,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1056,7 +1228,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1069,7 +1242,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1082,7 +1256,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1095,7 +1270,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1108,7 +1284,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1121,7 +1298,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1134,7 +1312,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1147,7 +1326,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1160,7 +1340,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1173,7 +1354,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1186,7 +1368,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1199,7 +1382,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2B6", @@ -1215,7 +1399,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -1301,9 +1486,13 @@ "reference": true }, "gene": "CYP2C19", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*38/*38" } ], @@ -1322,9 +1511,13 @@ "reference": true }, "gene": "CYP2C19", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*38/*38" } ], @@ -1341,7 +1534,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1354,7 +1548,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1367,7 +1562,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1380,7 +1576,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1393,7 +1590,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1409,7 +1607,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1422,7 +1621,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1435,7 +1635,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1448,7 +1649,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1461,7 +1663,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1474,7 +1677,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1487,7 +1691,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1501,7 +1706,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1514,7 +1720,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1527,7 +1734,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1540,7 +1748,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1553,7 +1762,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1567,7 +1777,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1580,7 +1791,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1593,7 +1805,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1606,7 +1819,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1619,7 +1833,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1632,7 +1847,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1645,7 +1861,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1658,7 +1875,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1671,7 +1889,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1711,7 +1930,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1724,7 +1944,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1737,7 +1958,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1750,7 +1972,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1763,7 +1986,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1776,7 +2000,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1789,7 +2014,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C19", @@ -1802,7 +2028,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -1817,7 +2044,17 @@ "*72", "*73", "*74", - "*75" + "*75", + "*76", + "*77", + "*78", + "*79", + "*80", + "*81", + "*82", + "*83", + "*84", + "*85" ], "messages": [], "relatedDrugs": [ @@ -1830,6 +2067,14 @@ "guidelineId": "RxNorm:4502" }, { + "name": "fluvastatin", + "guidelineId": "RxNorm:41127" + }, + { + "name": "fosphenytoin", + "guidelineId": "RxNorm:72236" + }, + { "name": "ibuprofen", "guidelineId": "RxNorm:5640" }, @@ -1842,6 +2087,10 @@ "guidelineId": "RxNorm:41493" }, { + "name": "phenytoin", + "guidelineId": "RxNorm:8183" + }, + { "name": "piroxicam", "guidelineId": "RxNorm:8356" }, @@ -1869,9 +2118,13 @@ "reference": true }, "gene": "CYP2C9", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "2", + "lookupKey": [ + "2" + ], "label": "*1/*1" } ], @@ -1890,9 +2143,13 @@ "reference": true }, "gene": "CYP2C9", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "2", + "lookupKey": [ + "2" + ], "label": "*1/*1" } ], @@ -1908,7 +2165,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -1921,7 +2179,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -1934,7 +2193,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -1947,7 +2207,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -1960,7 +2221,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -1973,7 +2235,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -1986,7 +2249,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -1999,7 +2263,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2012,7 +2277,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2025,7 +2291,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2038,7 +2305,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2051,7 +2319,8 @@ ], "phased": true, "wildtypeAllele": "CAATGGAAAGA", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2064,7 +2333,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2077,7 +2347,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2090,7 +2361,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2103,7 +2375,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2117,7 +2390,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2131,7 +2405,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2144,7 +2419,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2157,7 +2433,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2172,7 +2449,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2185,7 +2463,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2198,7 +2477,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2212,7 +2492,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2225,7 +2506,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2238,7 +2520,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2251,7 +2534,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2264,7 +2548,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2277,7 +2562,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2290,7 +2576,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2303,7 +2590,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2316,7 +2604,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2329,7 +2618,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2343,7 +2633,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2356,7 +2647,8 @@ ], "phased": true, "wildtypeAllele": "GA", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2369,7 +2661,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2382,7 +2675,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2395,7 +2689,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2408,7 +2703,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2421,7 +2717,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2434,7 +2731,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2447,7 +2745,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2460,7 +2759,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2473,7 +2773,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2486,7 +2787,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2499,7 +2801,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2512,7 +2815,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2525,7 +2829,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2540,7 +2845,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2553,7 +2859,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2566,7 +2873,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2579,7 +2887,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2592,7 +2901,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2605,7 +2915,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2618,7 +2929,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2631,7 +2943,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2644,7 +2957,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2657,7 +2971,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2670,7 +2985,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2683,7 +2999,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2696,7 +3013,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2709,7 +3027,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2722,7 +3041,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2735,7 +3055,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2749,7 +3070,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2762,7 +3084,78 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94938719, + "dbSnpId": null, + "call": null, + "alleles": [ + "*80" + ], + "phased": false, + "wildtypeAllele": "T", + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94938788, + "dbSnpId": null, + "call": null, + "alleles": [ + "*83" + ], + "phased": false, + "wildtypeAllele": "C", + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94938800, + "dbSnpId": "rs1364419386", + "call": null, + "alleles": [ + "*76" + ], + "phased": false, + "wildtypeAllele": "G", + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94941975, + "dbSnpId": null, + "call": null, + "alleles": [ + "*77" + ], + "phased": false, + "wildtypeAllele": "G", + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94942243, + "dbSnpId": "rs1375956433", + "call": null, + "alleles": [ + "*78" + ], + "phased": false, + "wildtypeAllele": "T", + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2775,7 +3168,8 @@ ], "phased": false, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2788,7 +3182,8 @@ ], "phased": false, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2801,7 +3196,64 @@ ], "phased": false, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94949145, + "dbSnpId": "rs772782449", + "call": null, + "alleles": [ + "*82" + ], + "phased": false, + "wildtypeAllele": "C", + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94949161, + "dbSnpId": null, + "call": null, + "alleles": [ + "*85" + ], + "phased": false, + "wildtypeAllele": "AT", + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94972183, + "dbSnpId": null, + "call": null, + "alleles": [ + "*81" + ], + "phased": false, + "wildtypeAllele": "A", + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94981258, + "dbSnpId": "rs1297714792", + "call": null, + "alleles": [ + "*79" + ], + "phased": false, + "wildtypeAllele": "C", + "mismatch": false, + "warnings": [] }, { "gene": "CYP2C9", @@ -2814,7 +3266,22 @@ ], "phased": false, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] + }, + { + "gene": "CYP2C9", + "chromosome": "chr10", + "position": 94986174, + "dbSnpId": "rs1441296358", + "call": null, + "alleles": [ + "*84" + ], + "phased": false, + "wildtypeAllele": "G", + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [ @@ -2827,7 +3294,8 @@ "alleles": [], "phased": true, "wildtypeAllele": null, - "mismatch": false + "mismatch": false, + "warnings": [] } ], "highlightedVariants": [] @@ -2838,23 +3306,7 @@ "phased": false, "callSource": "OUTSIDE", "uncalledHaplotypes": [], - "messages": [ - { - "rule_name": "CYP2D6 warning", - "version": "1", - "matches": { - "gene": "CYP2D6", - "hapsCalled": [], - "hapsMissing": [], - "variantsMissing": [], - "variant": "", - "dips": [], - "drugs": [] - }, - "exception_type": "note", - "message": "CYP2D6 genotypes are called by a separate algorithm from other genes in the PharmCAT report. Please refer to \u003ca href\u003d\"https://github.com/PharmGKB/PharmCAT/wiki/Determining-Alleles\"\u003ethe PharmCAT wiki\u003c/a\u003e for more information." - } - ], + "messages": [], "relatedDrugs": [ { "name": "amitriptyline", @@ -2921,27 +3373,7 @@ "guidelineId": "RxNorm:27392" } ], - "matcherDiplotypes": [ - { - "allele1": { - "gene": "CYP2D6", - "name": "*1", - "function": "Normal function", - "reference": true - }, - "allele2": { - "gene": "CYP2D6", - "name": "*3", - "function": "No function", - "reference": false - }, - "gene": "CYP2D6", - "phenotype": "Intermediate Metabolizer", - "variant": null, - "lookupKey": "1", - "label": "*1/*3" - } - ], + "matcherDiplotypes": [], "diplotypes": [ { "allele1": { @@ -2957,9 +3389,13 @@ "reference": false }, "gene": "CYP2D6", - "phenotype": "Intermediate Metabolizer", + "phenotypes": [ + "Intermediate Metabolizer" + ], "variant": null, - "lookupKey": "1", + "lookupKey": [ + "1" + ], "label": "*1/*3" } ], @@ -3011,9 +3447,13 @@ "reference": true }, "gene": "CYP3A5", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -3032,9 +3472,13 @@ "reference": true }, "gene": "CYP3A5", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -3042,20 +3486,6 @@ { "gene": "CYP3A5", "chromosome": "chr7", - "position": 99652613, - "dbSnpId": "rs28365083", - "call": "G|G", - "alleles": [ - "*2", - "*3" - ], - "phased": true, - "wildtypeAllele": "G", - "mismatch": false - }, - { - "gene": "CYP3A5", - "chromosome": "chr7", "position": 99652770, "dbSnpId": "rs41303343", "call": "T|T", @@ -3064,7 +3494,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP3A5", @@ -3073,12 +3504,12 @@ "dbSnpId": "rs28383479", "call": "C|C", "alleles": [ - "*3", "*9" ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP3A5", @@ -3091,35 +3522,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false - }, - { - "gene": "CYP3A5", - "chromosome": "chr7", - "position": 99665237, - "dbSnpId": "rs56411402", - "call": "T|T", - "alleles": [ - "*3", - "*4" - ], - "phased": true, - "wildtypeAllele": "T", - "mismatch": false - }, - { - "gene": "CYP3A5", - "chromosome": "chr7", - "position": 99666950, - "dbSnpId": "rs55965422", - "call": "A|A", - "alleles": [ - "*3", - "*5" - ], - "phased": true, - "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP3A5", @@ -3132,7 +3536,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP3A5", @@ -3145,7 +3550,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -3179,9 +3585,9 @@ "reference": true }, "gene": "CYP4F2", - "phenotype": null, + "phenotypes": [], "variant": null, - "lookupKey": null, + "lookupKey": [], "label": "*1/*1" } ], @@ -3200,9 +3606,9 @@ "reference": true }, "gene": "CYP4F2", - "phenotype": null, + "phenotypes": [], "variant": null, - "lookupKey": null, + "lookupKey": [], "label": "*1/*1" } ], @@ -3218,7 +3624,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "CYP4F2", @@ -3231,7 +3638,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -3285,9 +3693,13 @@ "reference": true }, "gene": "DPYD", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "2", + "lookupKey": [ + "2" + ], "label": "Reference/Reference" } ], @@ -3306,9 +3718,13 @@ "reference": true }, "gene": "DPYD", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "2", + "lookupKey": [ + "2" + ], "label": "Reference/Reference" } ], @@ -3324,7 +3740,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3337,7 +3754,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3350,7 +3768,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3363,7 +3782,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3376,7 +3796,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3389,7 +3810,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3402,7 +3824,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3415,7 +3838,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3428,7 +3852,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3441,7 +3866,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3454,7 +3880,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3467,7 +3894,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3480,7 +3908,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3493,7 +3922,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3506,7 +3936,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3519,7 +3950,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3532,7 +3964,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3545,7 +3978,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3558,7 +3992,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3571,7 +4006,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3584,7 +4020,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3597,7 +4034,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3610,7 +4048,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3623,7 +4062,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3636,7 +4076,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3649,7 +4090,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3662,7 +4104,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3675,7 +4118,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3688,7 +4132,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3701,7 +4146,8 @@ ], "phased": true, "wildtypeAllele": "TG", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3714,7 +4160,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3727,7 +4174,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3740,7 +4188,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3753,7 +4202,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3766,7 +4216,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3779,7 +4230,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3792,7 +4244,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3805,7 +4258,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3818,7 +4272,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3831,7 +4286,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3844,7 +4300,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3857,7 +4314,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3870,7 +4328,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3883,7 +4342,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3896,7 +4356,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3909,7 +4370,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3922,7 +4384,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3935,7 +4398,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3948,7 +4412,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3961,7 +4426,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3974,7 +4440,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -3987,7 +4454,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4000,7 +4468,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4013,7 +4482,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4026,7 +4496,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4039,7 +4510,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4052,7 +4524,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4065,7 +4538,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4078,7 +4552,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4091,7 +4566,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4104,7 +4580,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4117,7 +4594,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4130,7 +4608,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4143,7 +4622,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4156,7 +4636,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4169,7 +4650,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4182,7 +4664,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4195,7 +4678,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4208,7 +4692,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4221,7 +4706,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4234,7 +4720,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4247,7 +4734,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4260,7 +4748,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4273,7 +4762,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4286,7 +4776,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4299,7 +4790,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4312,7 +4804,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4325,7 +4818,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4338,7 +4832,8 @@ ], "phased": true, "wildtypeAllele": "GATGA", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4351,7 +4846,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4364,7 +4860,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4377,7 +4874,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "DPYD", @@ -4390,7 +4888,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -4409,27 +4908,7 @@ "guidelineId": "RxNorm:283821" } ], - "matcherDiplotypes": [ - { - "allele1": { - "gene": "G6PD", - "name": "B (wildtype)", - "function": "Normal function", - "reference": true - }, - "allele2": { - "gene": "G6PD", - "name": "B (wildtype)", - "function": "Normal function", - "reference": true - }, - "gene": "G6PD", - "phenotype": "Normal", - "variant": null, - "lookupKey": "Normal", - "label": "B (wildtype)/B (wildtype)" - } - ], + "matcherDiplotypes": [], "diplotypes": [ { "allele1": { @@ -4445,9 +4924,13 @@ "reference": true }, "gene": "G6PD", - "phenotype": "Normal", + "phenotypes": [ + "Normal" + ], "variant": null, - "lookupKey": "Normal", + "lookupKey": [ + "Normal" + ], "label": "B (wildtype)/B (wildtype)" } ], @@ -4503,9 +4986,9 @@ "reference": true }, "gene": "IFNL3", - "phenotype": null, + "phenotypes": [], "variant": null, - "lookupKey": null, + "lookupKey": [], "label": "rs12979860 reference (C)/rs12979860 reference (C)" } ], @@ -4524,9 +5007,9 @@ "reference": true }, "gene": "IFNL3", - "phenotype": null, + "phenotypes": [], "variant": null, - "lookupKey": null, + "lookupKey": [], "label": "rs12979860 reference (C)/rs12979860 reference (C)" } ], @@ -4542,7 +5025,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -4585,22 +5069,7 @@ "guidelineId": "RxNorm:10627" } ], - "matcherDiplotypes": [ - { - "allele1": { - "gene": "MT-RNR1", - "name": "1555A\u003eG", - "function": "increased risk of aminoglycoside-induced hearing loss", - "reference": false - }, - "allele2": null, - "gene": "MT-RNR1", - "phenotype": "increased risk of aminoglycoside-induced hearing loss", - "variant": null, - "lookupKey": "increased risk of aminoglycoside-induced hearing loss", - "label": "1555A\u003eG" - } - ], + "matcherDiplotypes": [], "diplotypes": [ { "allele1": { @@ -4611,9 +5080,13 @@ }, "allele2": null, "gene": "MT-RNR1", - "phenotype": "increased risk of aminoglycoside-induced hearing loss", + "phenotypes": [ + "increased risk of aminoglycoside-induced hearing loss" + ], "variant": null, - "lookupKey": "increased risk of aminoglycoside-induced hearing loss", + "lookupKey": [ + "increased risk of aminoglycoside-induced hearing loss" + ], "label": "1555A\u003eG" } ], @@ -4657,9 +5130,13 @@ "reference": true }, "gene": "NUDT15", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -4678,9 +5155,13 @@ "reference": true }, "gene": "NUDT15", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -4696,7 +5177,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4709,7 +5191,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4724,7 +5207,8 @@ ], "phased": true, "wildtypeAllele": "AGGAGTC", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4737,7 +5221,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4750,7 +5235,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4763,7 +5249,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4776,7 +5263,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4789,7 +5277,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4802,7 +5291,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4815,7 +5305,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4828,7 +5319,8 @@ ], "phased": true, "wildtypeAllele": "GA", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4841,7 +5333,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4854,7 +5347,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4867,7 +5361,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4881,7 +5376,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4894,7 +5390,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "NUDT15", @@ -4907,7 +5404,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -4965,9 +5463,13 @@ "reference": true }, "gene": "RYR1", - "phenotype": "Uncertain Susceptibility", + "phenotypes": [ + "Uncertain Susceptibility" + ], "variant": null, - "lookupKey": "Uncertain Susceptibility", + "lookupKey": [ + "Uncertain Susceptibility" + ], "label": "Reference/Reference" } ], @@ -4986,9 +5488,13 @@ "reference": true }, "gene": "RYR1", - "phenotype": "Uncertain Susceptibility", + "phenotypes": [ + "Uncertain Susceptibility" + ], "variant": null, - "lookupKey": "Uncertain Susceptibility", + "lookupKey": [ + "Uncertain Susceptibility" + ], "label": "Reference/Reference" } ], @@ -5004,7 +5510,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5017,7 +5524,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5030,7 +5538,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5043,7 +5552,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5057,7 +5567,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5070,7 +5581,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5084,7 +5596,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5097,7 +5610,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5110,7 +5624,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5123,7 +5638,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5136,7 +5652,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5149,7 +5666,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5162,7 +5680,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5175,7 +5694,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5188,7 +5708,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5201,7 +5722,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5214,7 +5736,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5227,7 +5750,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5240,7 +5764,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5254,7 +5779,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5267,7 +5793,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5280,7 +5807,8 @@ ], "phased": true, "wildtypeAllele": "TGGA", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5293,7 +5821,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5306,7 +5835,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5319,7 +5849,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5332,7 +5863,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5345,7 +5877,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5358,7 +5891,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5371,7 +5905,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5384,7 +5919,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5397,7 +5933,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5410,7 +5947,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5423,7 +5961,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5437,7 +5976,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5450,7 +5990,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5463,7 +6004,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5476,7 +6018,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5489,7 +6032,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5502,7 +6046,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5515,7 +6060,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5528,7 +6074,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5541,7 +6088,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5554,7 +6102,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "RYR1", @@ -5567,7 +6116,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -5586,6 +6136,30 @@ "messages": [], "relatedDrugs": [ { + "name": "atorvastatin", + "guidelineId": "RxNorm:83367" + }, + { + "name": "fluvastatin", + "guidelineId": "RxNorm:41127" + }, + { + "name": "lovastatin", + "guidelineId": "RxNorm:6472" + }, + { + "name": "pitavastatin", + "guidelineId": "RxNorm:861634" + }, + { + "name": "pravastatin", + "guidelineId": "RxNorm:42463" + }, + { + "name": "rosuvastatin", + "guidelineId": "RxNorm:301542" + }, + { "name": "simvastatin", "guidelineId": "RxNorm:36567" } @@ -5605,9 +6179,13 @@ "reference": true }, "gene": "SLCO1B1", - "phenotype": "Normal function", + "phenotypes": [ + "Normal Function" + ], "variant": null, - "lookupKey": "Normal function", + "lookupKey": [ + "Normal Function" + ], "label": "*1/*1" } ], @@ -5626,9 +6204,13 @@ "reference": true }, "gene": "SLCO1B1", - "phenotype": "Normal function", + "phenotypes": [ + "Normal Function" + ], "variant": null, - "lookupKey": "Normal function", + "lookupKey": [ + "Normal Function" + ], "label": "*1/*1" } ], @@ -5644,7 +6226,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5657,7 +6240,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5671,7 +6255,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5685,7 +6270,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5716,7 +6302,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5729,7 +6316,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5746,7 +6334,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5760,7 +6349,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5777,7 +6367,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5790,7 +6381,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5809,7 +6401,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5824,7 +6417,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5837,7 +6431,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5850,7 +6445,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5863,7 +6459,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5876,7 +6473,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5889,7 +6487,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5902,7 +6501,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5916,7 +6516,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5931,7 +6532,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5945,7 +6547,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5959,7 +6562,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5972,7 +6576,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5985,7 +6590,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -5998,7 +6604,8 @@ ], "phased": false, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -6011,7 +6618,8 @@ ], "phased": false, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -6024,7 +6632,8 @@ ], "phased": false, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -6037,7 +6646,8 @@ ], "phased": false, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -6050,7 +6660,8 @@ ], "phased": false, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -6064,7 +6675,8 @@ ], "phased": false, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "SLCO1B1", @@ -6078,7 +6690,8 @@ ], "phased": false, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -6138,9 +6751,13 @@ "reference": true }, "gene": "TPMT", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -6159,9 +6776,13 @@ "reference": true }, "gene": "TPMT", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -6179,7 +6800,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6192,7 +6814,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6205,7 +6828,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6218,7 +6842,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6231,7 +6856,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6244,7 +6870,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6257,7 +6884,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6270,7 +6898,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6283,7 +6912,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6296,7 +6926,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6309,7 +6940,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6322,7 +6954,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6335,7 +6968,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6348,7 +6982,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6361,7 +6996,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6374,7 +7010,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6387,7 +7024,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6401,7 +7039,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6414,7 +7053,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6428,7 +7068,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6441,7 +7082,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6454,7 +7096,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6467,7 +7110,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6480,7 +7124,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6493,7 +7138,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6506,7 +7152,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6519,7 +7166,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6532,7 +7180,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6545,7 +7194,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6558,7 +7208,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6571,7 +7222,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6584,7 +7236,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6597,7 +7250,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6610,7 +7264,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6623,7 +7278,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6636,7 +7292,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6649,7 +7306,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6662,7 +7320,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6675,7 +7334,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6688,7 +7348,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6701,7 +7362,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6714,7 +7376,8 @@ ], "phased": true, "wildtypeAllele": "A", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "TPMT", @@ -6727,7 +7390,8 @@ ], "phased": true, "wildtypeAllele": "T", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -6777,9 +7441,13 @@ "reference": true }, "gene": "UGT1A1", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -6798,9 +7466,13 @@ "reference": true }, "gene": "UGT1A1", - "phenotype": "Normal Metabolizer", + "phenotypes": [ + "Normal Metabolizer" + ], "variant": null, - "lookupKey": "Normal Metabolizer", + "lookupKey": [ + "Normal Metabolizer" + ], "label": "*1/*1" } ], @@ -6818,7 +7490,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "UGT1A1", @@ -6835,7 +7508,8 @@ ], "phased": true, "wildtypeAllele": "CAT", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "UGT1A1", @@ -6848,7 +7522,8 @@ ], "phased": true, "wildtypeAllele": "G", - "mismatch": false + "mismatch": false, + "warnings": [] }, { "gene": "UGT1A1", @@ -6861,7 +7536,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [], @@ -6926,9 +7602,9 @@ "reference": true }, "gene": "VKORC1", - "phenotype": null, + "phenotypes": [], "variant": null, - "lookupKey": null, + "lookupKey": [], "label": "rs9923231 reference (C)/rs9923231 reference (C)" } ], @@ -6947,9 +7623,9 @@ "reference": true }, "gene": "VKORC1", - "phenotype": null, + "phenotypes": [], "variant": null, - "lookupKey": null, + "lookupKey": [], "label": "rs9923231 reference (C)/rs9923231 reference (C)" } ], @@ -6965,7 +7641,8 @@ ], "phased": true, "wildtypeAllele": "C", - "mismatch": false + "mismatch": false, + "warnings": [] } ], "variantsOfInterest": [],