Mercurial > repos > bgruening > pharmcat

view test-data/test_1.pheno.json @ 0:d67642a21a1d draft

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"planemo upload for repository https://github.com/bgruening/galaxytools/tree/master/tools/pharmcat commit c6a098eb0cbfa87b0feaebf10ef6b24da659fa54"
author bgruening
date Fri, 28 Jan 2022 21:18:23 +0000
parents
children 891283e0ee89
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[
  {
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    "chr": "chr1",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [],
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      {
        "name": "desflurane",
        "guidelineId": "RxNorm:27340"
      },
      {
        "name": "enflurane",
        "guidelineId": "RxNorm:3920"
      },
      {
        "name": "halothane",
        "guidelineId": "RxNorm:5095"
      },
      {
        "name": "isoflurane",
        "guidelineId": "RxNorm:6026"
      },
      {
        "name": "methoxyflurane",
        "guidelineId": "RxNorm:6857"
      },
      {
        "name": "sevoflurane",
        "guidelineId": "RxNorm:36453"
      },
      {
        "name": "succinylcholine",
        "guidelineId": "RxNorm:10154"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "CACNA1S",
          "name": "Reference",
          "function": "Normal Function",
          "reference": true
        },
        "allele2": {
          "gene": "CACNA1S",
          "name": "Reference",
          "function": "Normal Function",
          "reference": true
        },
        "gene": "CACNA1S",
        "phenotype": "Uncertain Susceptibility",
        "variant": null,
        "lookupKey": "Uncertain Susceptibility",
        "label": "Reference/Reference"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
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          "function": "Normal Function",
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        },
        "allele2": {
          "gene": "CACNA1S",
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          "function": "Normal Function",
          "reference": true
        },
        "gene": "CACNA1S",
        "phenotype": "Uncertain Susceptibility",
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      }
    ],
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      {
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      },
      {
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      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": []
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      {
        "name": "ivacaftor",
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    ],
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      {
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          "function": "ivacaftor non-responsive",
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        "allele2": {
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          "function": "ivacaftor non-responsive",
          "reference": true
        },
        "gene": "CFTR",
        "phenotype": "ivacaftor non-responsive in CF patients",
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        "lookupKey": "ivacaftor non-responsive in CF patients",
        "label": "No CPIC variants found"
      }
    ],
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        "lookupKey": "ivacaftor non-responsive in CF patients",
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      }
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        "alleles": [
          "*19"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94988925,
        "dbSnpId": "rs202201137",
        "call": "A|A",
        "alleles": [
          "*61"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94988955,
        "dbSnpId": "rs767284820",
        "call": "T|T",
        "alleles": [
          "*60"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94988984,
        "dbSnpId": "rs781583846",
        "call": "G|G",
        "alleles": [
          "*30"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94989020,
        "dbSnpId": "rs9332239",
        "call": "C|C",
        "alleles": [
          "*12",
          "*71"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94989023,
        "dbSnpId": "rs868182778",
        "call": "G|G",
        "alleles": [
          "*32"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94942306,
        "dbSnpId": "rs1289704600",
        "call": null,
        "alleles": [
          "*72"
        ],
        "phased": false,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94942308,
        "dbSnpId": "rs17847037",
        "call": null,
        "alleles": [
          "*73"
        ],
        "phased": false,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94947439,
        "dbSnpId": null,
        "call": null,
        "alleles": [
          "*74"
        ],
        "phased": false,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94986136,
        "dbSnpId": "rs1254213342",
        "call": null,
        "alleles": [
          "*75"
        ],
        "phased": false,
        "wildtypeAllele": "A",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [
      {
        "gene": "CYP2C9",
        "chromosome": "chr10",
        "position": 94645745,
        "dbSnpId": "rs12777823",
        "call": "G|G",
        "alleles": [],
        "phased": true,
        "wildtypeAllele": null,
        "mismatch": false
      }
    ],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "CYP2D6",
    "chr": null,
    "phased": false,
    "callSource": "OUTSIDE",
    "uncalledHaplotypes": [],
    "messages": [
      {
        "rule_name": "CYP2D6 warning",
        "version": "1",
        "matches": {
          "gene": "CYP2D6",
          "hapsCalled": [],
          "hapsMissing": [],
          "variantsMissing": [],
          "variant": "",
          "dips": [],
          "drugs": []
        },
        "exception_type": "note",
        "message": "CYP2D6 genotypes are called by a separate algorithm from other genes in the PharmCAT report.  Please refer to \u003ca href\u003d\"https://github.com/PharmGKB/PharmCAT/wiki/Determining-Alleles\"\u003ethe PharmCAT wiki\u003c/a\u003e for more information."
      }
    ],
    "relatedDrugs": [
      {
        "name": "amitriptyline",
        "guidelineId": "RxNorm:704"
      },
      {
        "name": "atomoxetine",
        "guidelineId": "RxNorm:38400"
      },
      {
        "name": "clomipramine",
        "guidelineId": "RxNorm:2597"
      },
      {
        "name": "codeine",
        "guidelineId": "RxNorm:2670"
      },
      {
        "name": "desipramine",
        "guidelineId": "RxNorm:3247"
      },
      {
        "name": "doxepin",
        "guidelineId": "RxNorm:3638"
      },
      {
        "name": "fluvoxamine",
        "guidelineId": "RxNorm:42355"
      },
      {
        "name": "hydrocodone",
        "guidelineId": "RxNorm:5489"
      },
      {
        "name": "imipramine",
        "guidelineId": "RxNorm:5691"
      },
      {
        "name": "nortriptyline",
        "guidelineId": "RxNorm:7531"
      },
      {
        "name": "ondansetron",
        "guidelineId": "RxNorm:26225"
      },
      {
        "name": "paroxetine",
        "guidelineId": "RxNorm:32937"
      },
      {
        "name": "tamoxifen",
        "guidelineId": "RxNorm:10324"
      },
      {
        "name": "tramadol",
        "guidelineId": "RxNorm:10689"
      },
      {
        "name": "trimipramine",
        "guidelineId": "RxNorm:10834"
      },
      {
        "name": "tropisetron",
        "guidelineId": "RxNorm:27392"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "CYP2D6",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "CYP2D6",
          "name": "*3",
          "function": "No function",
          "reference": false
        },
        "gene": "CYP2D6",
        "phenotype": "Intermediate Metabolizer",
        "variant": null,
        "lookupKey": "1",
        "label": "*1/*3"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "CYP2D6",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "CYP2D6",
          "name": "*3",
          "function": "No function",
          "reference": false
        },
        "gene": "CYP2D6",
        "phenotype": "Intermediate Metabolizer",
        "variant": null,
        "lookupKey": "1",
        "label": "*1/*3"
      }
    ],
    "variants": [],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "CYP3A5",
    "chr": "chr7",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [
      {
        "rule_name": "CYP3A5 reverse complement footnote",
        "version": "1",
        "matches": {
          "gene": "CYP3A5",
          "hapsCalled": [],
          "hapsMissing": [],
          "variantsMissing": [],
          "variant": "",
          "dips": [],
          "drugs": []
        },
        "exception_type": "footnote",
        "message": "The CYP3A5 gene is on the negative chromosomal strand, all genotype calls for CYP3A5 in this report refer to the positive chromosomal strand.  Therefore, genotype calls are complemented from gene bases."
      }
    ],
    "relatedDrugs": [
      {
        "name": "tacrolimus",
        "guidelineId": "RxNorm:42316"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "CYP3A5",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "CYP3A5",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "gene": "CYP3A5",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "Normal Metabolizer",
        "label": "*1/*1"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "CYP3A5",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "CYP3A5",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "gene": "CYP3A5",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "Normal Metabolizer",
        "label": "*1/*1"
      }
    ],
    "variants": [
      {
        "gene": "CYP3A5",
        "chromosome": "chr7",
        "position": 99652613,
        "dbSnpId": "rs28365083",
        "call": "G|G",
        "alleles": [
          "*2",
          "*3"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "CYP3A5",
        "chromosome": "chr7",
        "position": 99652770,
        "dbSnpId": "rs41303343",
        "call": "T|T",
        "alleles": [
          "*7"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "CYP3A5",
        "chromosome": "chr7",
        "position": 99660516,
        "dbSnpId": "rs28383479",
        "call": "C|C",
        "alleles": [
          "*3",
          "*9"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "CYP3A5",
        "chromosome": "chr7",
        "position": 99665212,
        "dbSnpId": "rs10264272",
        "call": "C|C",
        "alleles": [
          "*6"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "CYP3A5",
        "chromosome": "chr7",
        "position": 99665237,
        "dbSnpId": "rs56411402",
        "call": "T|T",
        "alleles": [
          "*3",
          "*4"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "CYP3A5",
        "chromosome": "chr7",
        "position": 99666950,
        "dbSnpId": "rs55965422",
        "call": "A|A",
        "alleles": [
          "*3",
          "*5"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "CYP3A5",
        "chromosome": "chr7",
        "position": 99672916,
        "dbSnpId": "rs776746",
        "call": "T|T",
        "alleles": [
          "*3"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "CYP3A5",
        "chromosome": "chr7",
        "position": 99676198,
        "dbSnpId": "rs55817950",
        "call": "G|G",
        "alleles": [
          "*8"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "CYP4F2",
    "chr": "chr19",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [],
    "relatedDrugs": [
      {
        "name": "warfarin",
        "guidelineId": "RxNorm:11289"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "CYP4F2",
          "name": "*1",
          "function": null,
          "reference": true
        },
        "allele2": {
          "gene": "CYP4F2",
          "name": "*1",
          "function": null,
          "reference": true
        },
        "gene": "CYP4F2",
        "phenotype": null,
        "variant": null,
        "lookupKey": null,
        "label": "*1/*1"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "CYP4F2",
          "name": "*1",
          "function": null,
          "reference": true
        },
        "allele2": {
          "gene": "CYP4F2",
          "name": "*1",
          "function": null,
          "reference": true
        },
        "gene": "CYP4F2",
        "phenotype": null,
        "variant": null,
        "lookupKey": null,
        "label": "*1/*1"
      }
    ],
    "variants": [
      {
        "gene": "CYP4F2",
        "chromosome": "chr19",
        "position": 15879621,
        "dbSnpId": "rs2108622",
        "call": "C|C",
        "alleles": [
          "*3"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "CYP4F2",
        "chromosome": "chr19",
        "position": 15897578,
        "dbSnpId": "rs3093105",
        "call": "A|A",
        "alleles": [
          "*2"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "DPYD",
    "chr": "chr1",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [
      {
        "rule_name": "DPYD reverse complement footnote",
        "version": "1",
        "matches": {
          "gene": "DPYD",
          "hapsCalled": [],
          "hapsMissing": [],
          "variantsMissing": [],
          "variant": "",
          "dips": [],
          "drugs": []
        },
        "exception_type": "footnote",
        "message": "The DPYD gene is on the negative chromosomal strand, all genotype calls for DPYD in this report refer to the positive chromosomal strand.  Therefore, genotype calls are complemented from gene bases."
      }
    ],
    "relatedDrugs": [
      {
        "name": "capecitabine",
        "guidelineId": "RxNorm:194000"
      },
      {
        "name": "fluorouracil",
        "guidelineId": "RxNorm:4492"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "DPYD",
          "name": "Reference",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "DPYD",
          "name": "Reference",
          "function": "Normal function",
          "reference": true
        },
        "gene": "DPYD",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "2",
        "label": "Reference/Reference"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "DPYD",
          "name": "Reference",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "DPYD",
          "name": "Reference",
          "function": "Normal function",
          "reference": true
        },
        "gene": "DPYD",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "2",
        "label": "Reference/Reference"
      }
    ],
    "variants": [
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97078987,
        "dbSnpId": "rs114096998",
        "call": "G|G",
        "alleles": [
          "c.3067C\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97078993,
        "dbSnpId": "rs148799944",
        "call": "C|C",
        "alleles": [
          "c.3061G\u003eC"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97079005,
        "dbSnpId": "rs140114515",
        "call": "C|C",
        "alleles": [
          "c.3049G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97079071,
        "dbSnpId": "rs1801268",
        "call": "C|C",
        "alleles": [
          "c.2983G\u003eT (*10)"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97079076,
        "dbSnpId": "rs139459586",
        "call": "A|A",
        "alleles": [
          "c.2978T\u003eG"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97079077,
        "dbSnpId": "rs202144771",
        "call": "G|G",
        "alleles": [
          "c.2977C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97079121,
        "dbSnpId": "rs72547601",
        "call": "T|T",
        "alleles": [
          "c.2933A\u003eG"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97079133,
        "dbSnpId": "rs72547602",
        "call": "T|T",
        "alleles": [
          "c.2921A\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97079139,
        "dbSnpId": "rs145529148",
        "call": "T|T",
        "alleles": [
          "c.2915A\u003eG"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97082365,
        "dbSnpId": "rs141044036",
        "call": "T|T",
        "alleles": [
          "c.2872A\u003eG"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97082391,
        "dbSnpId": "rs67376798",
        "call": "T|T",
        "alleles": [
          "c.2846A\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97098598,
        "dbSnpId": "rs1801267",
        "call": "C|C",
        "alleles": [
          "c.2657G\u003eA (*9B)"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97098599,
        "dbSnpId": "rs147545709",
        "call": "G|G",
        "alleles": [
          "c.2656C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97098616,
        "dbSnpId": "rs55674432",
        "call": "C|C",
        "alleles": [
          "c.2639G\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97098632,
        "dbSnpId": "rs201035051",
        "call": "T|T",
        "alleles": [
          "c.2623A\u003eC"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97193109,
        "dbSnpId": "rs60139309",
        "call": "T|T",
        "alleles": [
          "c.2582A\u003eG"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97193209,
        "dbSnpId": "rs200687447",
        "call": "C|C",
        "alleles": [
          "c.2482G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97234958,
        "dbSnpId": "rs199634007",
        "call": "G|G",
        "alleles": [
          "c.2336C\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97234991,
        "dbSnpId": "rs56005131",
        "call": "G|G",
        "alleles": [
          "c.2303C\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97305279,
        "dbSnpId": "rs112766203",
        "call": "G|G",
        "alleles": [
          "c.2279C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "DPYD",
        "chromosome": "chr1",
        "position": 97305363,
        "dbSnpId": "rs60511679",
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        "alleles": [
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        "phenotype": "Normal",
        "variant": null,
        "lookupKey": "Normal",
        "label": "B (wildtype)/B (wildtype)"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "G6PD",
          "name": "B (wildtype)",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "G6PD",
          "name": "B (wildtype)",
          "function": "Normal function",
          "reference": true
        },
        "gene": "G6PD",
        "phenotype": "Normal",
        "variant": null,
        "lookupKey": "Normal",
        "label": "B (wildtype)/B (wildtype)"
      }
    ],
    "variants": [],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "IFNL3",
    "chr": "chr19",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [
      {
        "rule_name": "IFNL3 reverse complement footnote",
        "version": "1",
        "matches": {
          "gene": "IFNL3",
          "hapsCalled": [],
          "hapsMissing": [],
          "variantsMissing": [],
          "variant": "",
          "dips": [],
          "drugs": []
        },
        "exception_type": "footnote",
        "message": "The IFNL3 gene is on the negative chromosomal strand, all genotype calls for IFNL3 in this report refer to the positive chromosomal strand.  Therefore, genotype calls are complemented from gene bases."
      }
    ],
    "relatedDrugs": [
      {
        "name": "peginterferon alfa-2a",
        "guidelineId": "RxNorm:120608"
      },
      {
        "name": "peginterferon alfa-2b",
        "guidelineId": "RxNorm:253453"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "IFNL3",
          "name": "rs12979860 reference (C)",
          "function": null,
          "reference": true
        },
        "allele2": {
          "gene": "IFNL3",
          "name": "rs12979860 reference (C)",
          "function": null,
          "reference": true
        },
        "gene": "IFNL3",
        "phenotype": null,
        "variant": null,
        "lookupKey": null,
        "label": "rs12979860 reference (C)/rs12979860 reference (C)"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "IFNL3",
          "name": "rs12979860 reference (C)",
          "function": null,
          "reference": true
        },
        "allele2": {
          "gene": "IFNL3",
          "name": "rs12979860 reference (C)",
          "function": null,
          "reference": true
        },
        "gene": "IFNL3",
        "phenotype": null,
        "variant": null,
        "lookupKey": null,
        "label": "rs12979860 reference (C)/rs12979860 reference (C)"
      }
    ],
    "variants": [
      {
        "gene": "IFNL3",
        "chromosome": "chr19",
        "position": 39248147,
        "dbSnpId": "rs12979860",
        "call": "C|C",
        "alleles": [
          "rs12979860 variant (T)"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "MT-RNR1",
    "chr": null,
    "phased": false,
    "callSource": "OUTSIDE",
    "uncalledHaplotypes": [],
    "messages": [],
    "relatedDrugs": [
      {
        "name": "amikacin",
        "guidelineId": "RxNorm:641"
      },
      {
        "name": "gentamicin",
        "guidelineId": "ATC:D06AX07"
      },
      {
        "name": "kanamycin",
        "guidelineId": "RxNorm:6099"
      },
      {
        "name": "paromomycin",
        "guidelineId": "RxNorm:7934"
      },
      {
        "name": "plazomicin",
        "guidelineId": "RxNorm:2049549"
      },
      {
        "name": "streptomycin",
        "guidelineId": "RxNorm:10109"
      },
      {
        "name": "tobramycin",
        "guidelineId": "RxNorm:10627"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "MT-RNR1",
          "name": "1555A\u003eG",
          "function": "increased risk of aminoglycoside-induced hearing loss",
          "reference": false
        },
        "allele2": null,
        "gene": "MT-RNR1",
        "phenotype": "increased risk of aminoglycoside-induced hearing loss",
        "variant": null,
        "lookupKey": "increased risk of aminoglycoside-induced hearing loss",
        "label": "1555A\u003eG"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "MT-RNR1",
          "name": "1555A\u003eG",
          "function": "increased risk of aminoglycoside-induced hearing loss",
          "reference": false
        },
        "allele2": null,
        "gene": "MT-RNR1",
        "phenotype": "increased risk of aminoglycoside-induced hearing loss",
        "variant": null,
        "lookupKey": "increased risk of aminoglycoside-induced hearing loss",
        "label": "1555A\u003eG"
      }
    ],
    "variants": [],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "NUDT15",
    "chr": "chr13",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [],
    "relatedDrugs": [
      {
        "name": "azathioprine",
        "guidelineId": "RxNorm:1256"
      },
      {
        "name": "mercaptopurine",
        "guidelineId": "RxNorm:103"
      },
      {
        "name": "thioguanine",
        "guidelineId": "RxNorm:10485"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "NUDT15",
          "name": "*1",
          "function": "Normal Function",
          "reference": true
        },
        "allele2": {
          "gene": "NUDT15",
          "name": "*1",
          "function": "Normal Function",
          "reference": true
        },
        "gene": "NUDT15",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "Normal Metabolizer",
        "label": "*1/*1"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "NUDT15",
          "name": "*1",
          "function": "Normal Function",
          "reference": true
        },
        "allele2": {
          "gene": "NUDT15",
          "name": "*1",
          "function": "Normal Function",
          "reference": true
        },
        "gene": "NUDT15",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "Normal Metabolizer",
        "label": "*1/*1"
      }
    ],
    "variants": [
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037748,
        "dbSnpId": "rs769369441",
        "call": "T|T",
        "alleles": [
          "*10"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037749,
        "dbSnpId": null,
        "call": "G|G",
        "alleles": [
          "*19"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037782,
        "dbSnpId": "rs746071566",
        "call": "AGGAGTC|AGGAGTC",
        "alleles": [
          "*2",
          "*6",
          "*9"
        ],
        "phased": true,
        "wildtypeAllele": "AGGAGTC",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037798,
        "dbSnpId": "rs186364861",
        "call": "G|G",
        "alleles": [
          "*5"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037825,
        "dbSnpId": "rs777311140",
        "call": "C|C",
        "alleles": [
          "*14"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037834,
        "dbSnpId": "rs1202487323",
        "call": "C|C",
        "alleles": [
          "*16"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037847,
        "dbSnpId": "rs766023281",
        "call": "G|G",
        "alleles": [
          "*7"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037849,
        "dbSnpId": null,
        "call": "A|A",
        "alleles": [
          "*8"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037885,
        "dbSnpId": "rs1950545307",
        "call": "G|G",
        "alleles": [
          "*11"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48037902,
        "dbSnpId": "rs149436418",
        "call": "C|C",
        "alleles": [
          "*12"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48040977,
        "dbSnpId": "rs1457579126",
        "call": "GA|GA",
        "alleles": [
          "*18"
        ],
        "phased": true,
        "wildtypeAllele": "GA",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48041103,
        "dbSnpId": "rs761191455",
        "call": "T|T",
        "alleles": [
          "*13"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48041113,
        "dbSnpId": "rs1368252918",
        "call": "G|G",
        "alleles": [
          "*17"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48045690,
        "dbSnpId": "rs768324690",
        "call": "C|C",
        "alleles": [
          "*20"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48045719,
        "dbSnpId": "rs116855232",
        "call": "C|C",
        "alleles": [
          "*2",
          "*3"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48045720,
        "dbSnpId": "rs147390019",
        "call": "G|G",
        "alleles": [
          "*4"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "NUDT15",
        "chromosome": "chr13",
        "position": 48045771,
        "dbSnpId": "rs139551410",
        "call": "T|T",
        "alleles": [
          "*15"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "RYR1",
    "chr": "chr19",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [],
    "relatedDrugs": [
      {
        "name": "desflurane",
        "guidelineId": "RxNorm:27340"
      },
      {
        "name": "enflurane",
        "guidelineId": "RxNorm:3920"
      },
      {
        "name": "halothane",
        "guidelineId": "RxNorm:5095"
      },
      {
        "name": "isoflurane",
        "guidelineId": "RxNorm:6026"
      },
      {
        "name": "methoxyflurane",
        "guidelineId": "RxNorm:6857"
      },
      {
        "name": "sevoflurane",
        "guidelineId": "RxNorm:36453"
      },
      {
        "name": "succinylcholine",
        "guidelineId": "RxNorm:10154"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "RYR1",
          "name": "Reference",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "RYR1",
          "name": "Reference",
          "function": "Normal function",
          "reference": true
        },
        "gene": "RYR1",
        "phenotype": "Uncertain Susceptibility",
        "variant": null,
        "lookupKey": "Uncertain Susceptibility",
        "label": "Reference/Reference"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "RYR1",
          "name": "Reference",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "RYR1",
          "name": "Reference",
          "function": "Normal function",
          "reference": true
        },
        "gene": "RYR1",
        "phenotype": "Uncertain Susceptibility",
        "variant": null,
        "lookupKey": "Uncertain Susceptibility",
        "label": "Reference/Reference"
      }
    ],
    "variants": [
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38440802,
        "dbSnpId": "rs193922747",
        "call": "T|T",
        "alleles": [
          "c.103T\u003eC"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38440829,
        "dbSnpId": "rs193922748",
        "call": "C|C",
        "alleles": [
          "c.130C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38444211,
        "dbSnpId": "rs118192161",
        "call": "C|C",
        "alleles": [
          "c.487C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38444212,
        "dbSnpId": "rs193922753",
        "call": "G|G",
        "alleles": [
          "c.488G\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38446710,
        "dbSnpId": "rs1801086",
        "call": "G|G",
        "alleles": [
          "c.742G\u003eA",
          "c.742G\u003eC"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38448673,
        "dbSnpId": "rs193922762",
        "call": "C|C",
        "alleles": [
          "c.982C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38448712,
        "dbSnpId": "rs121918592",
        "call": "G|G",
        "alleles": [
          "c.1021G\u003eA",
          "c.1021G\u003eC"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38451842,
        "dbSnpId": "rs193922764",
        "call": "C|C",
        "alleles": [
          "c.1201C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38451850,
        "dbSnpId": "rs118192116",
        "call": "C|C",
        "alleles": [
          "c.1209C\u003eG"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38455359,
        "dbSnpId": "rs118192162",
        "call": "A|A",
        "alleles": [
          "c.1565A\u003eC"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38455463,
        "dbSnpId": "rs111888148",
        "call": "G|G",
        "alleles": [
          "c.1589G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38455471,
        "dbSnpId": "rs193922768",
        "call": "C|C",
        "alleles": [
          "c.1597C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38455472,
        "dbSnpId": "rs144336148",
        "call": "G|G",
        "alleles": [
          "c.1598G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38455528,
        "dbSnpId": "rs193922770",
        "call": "C|C",
        "alleles": [
          "c.1654C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38457545,
        "dbSnpId": "rs118192172",
        "call": "C|C",
        "alleles": [
          "c.1840C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38457546,
        "dbSnpId": "rs193922772",
        "call": "G|G",
        "alleles": [
          "c.1841G\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38494564,
        "dbSnpId": "rs118192175",
        "call": "C|C",
        "alleles": [
          "c.6487C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38494565,
        "dbSnpId": "rs118192163",
        "call": "G|G",
        "alleles": [
          "c.6488G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38494579,
        "dbSnpId": "rs118192176",
        "call": "G|G",
        "alleles": [
          "c.6502G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38496283,
        "dbSnpId": "rs118192177",
        "call": "C|C",
        "alleles": [
          "c.6617C\u003eG",
          "c.6617C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38499223,
        "dbSnpId": "rs112563513",
        "call": "G|G",
        "alleles": [
          "c.7007G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38499644,
        "dbSnpId": "rs121918596",
        "call": "TGGA|TGGA",
        "alleles": [
          "c.7042_7044delGAG"
        ],
        "phased": true,
        "wildtypeAllele": "TGGA",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38499655,
        "dbSnpId": "rs193922802",
        "call": "G|G",
        "alleles": [
          "c.7048G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38499670,
        "dbSnpId": "rs193922803",
        "call": "C|C",
        "alleles": [
          "c.7063C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38499731,
        "dbSnpId": "rs193922807",
        "call": "G|G",
        "alleles": [
          "c.7124G\u003eC"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38499975,
        "dbSnpId": "rs193922809",
        "call": "G|G",
        "alleles": [
          "c.7282G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38499993,
        "dbSnpId": "rs121918593",
        "call": "G|G",
        "alleles": [
          "c.7300G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38499997,
        "dbSnpId": "rs28933396",
        "call": "G|G",
        "alleles": [
          "c.7304G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38500636,
        "dbSnpId": "rs118192124",
        "call": "C|C",
        "alleles": [
          "c.7354C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38500642,
        "dbSnpId": "rs193922816",
        "call": "C|C",
        "alleles": [
          "c.7360C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38500643,
        "dbSnpId": "rs118192122",
        "call": "G|G",
        "alleles": [
          "c.7361G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38500654,
        "dbSnpId": "rs28933397",
        "call": "C|C",
        "alleles": [
          "c.7372C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38500655,
        "dbSnpId": "rs121918594",
        "call": "G|G",
        "alleles": [
          "c.7373G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38500898,
        "dbSnpId": "rs118192178",
        "call": "C|C",
        "alleles": [
          "c.7522C\u003eG",
          "c.7522C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38500899,
        "dbSnpId": "rs193922818",
        "call": "G|G",
        "alleles": [
          "c.7523G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38512321,
        "dbSnpId": "rs193922832",
        "call": "G|G",
        "alleles": [
          "c.9310G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38543832,
        "dbSnpId": "rs193922843",
        "call": "G|G",
        "alleles": [
          "c.11969G\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38580004,
        "dbSnpId": "rs118192167",
        "call": "A|A",
        "alleles": [
          "c.14387A\u003eG"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38580094,
        "dbSnpId": "rs121918595",
        "call": "C|C",
        "alleles": [
          "c.14477C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38580114,
        "dbSnpId": "rs193922876",
        "call": "C|C",
        "alleles": [
          "c.14497C\u003eT"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38580370,
        "dbSnpId": "rs193922878",
        "call": "C|C",
        "alleles": [
          "c.14512C\u003eG"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38580403,
        "dbSnpId": "rs118192168",
        "call": "G|G",
        "alleles": [
          "c.14545G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38580440,
        "dbSnpId": "rs63749869",
        "call": "G|G",
        "alleles": [
          "c.14582G\u003eA"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "RYR1",
        "chromosome": "chr19",
        "position": 38584989,
        "dbSnpId": "rs118192170",
        "call": "T|T",
        "alleles": [
          "c.14693T\u003eC"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "SLCO1B1",
    "chr": "chr12",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [
      "*38",
      "*41",
      "*45"
    ],
    "messages": [],
    "relatedDrugs": [
      {
        "name": "simvastatin",
        "guidelineId": "RxNorm:36567"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "SLCO1B1",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "SLCO1B1",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "gene": "SLCO1B1",
        "phenotype": "Normal function",
        "variant": null,
        "lookupKey": "Normal function",
        "label": "*1/*1"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "SLCO1B1",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "SLCO1B1",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "gene": "SLCO1B1",
        "phenotype": "Normal function",
        "variant": null,
        "lookupKey": "Normal function",
        "label": "*1/*1"
      }
    ],
    "variants": [
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21172734,
        "dbSnpId": "rs139257324",
        "call": "C|C",
        "alleles": [
          "*33"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21172776,
        "dbSnpId": "rs373327528",
        "call": "G|G",
        "alleles": [
          "*23"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21172782,
        "dbSnpId": "rs56101265",
        "call": "T|T",
        "alleles": [
          "*2",
          "*12"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21174595,
        "dbSnpId": "rs56061388",
        "call": "T|T",
        "alleles": [
          "*3",
          "*13"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21176804,
        "dbSnpId": "rs2306283",
        "call": "A|A",
        "alleles": [
          "*14",
          "*15",
          "*20",
          "*24",
          "*25",
          "*27",
          "*28",
          "*29",
          "*30",
          "*31",
          "*32",
          "*33",
          "*37",
          "*39",
          "*42",
          "*43",
          "*44",
          "*46",
          "*47"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21176868,
        "dbSnpId": "rs2306282",
        "call": "A|A",
        "alleles": [
          "*16"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21176879,
        "dbSnpId": "rs11045819",
        "call": "C|C",
        "alleles": [
          "*4",
          "*14",
          "*25",
          "*32",
          "*43"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21176883,
        "dbSnpId": "rs72559745",
        "call": "A|A",
        "alleles": [
          "*3",
          "*13"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21178615,
        "dbSnpId": "rs4149056",
        "call": "T|T",
        "alleles": [
          "*5",
          "*15",
          "*40",
          "*46",
          "*47"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21178957,
        "dbSnpId": "rs79135870",
        "call": "A|A",
        "alleles": [
          "*30"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21196951,
        "dbSnpId": "rs11045852",
        "call": "A|A",
        "alleles": [
          "*24",
          "*25",
          "*28",
          "*32",
          "*33",
          "*43",
          "*44"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21196976,
        "dbSnpId": "rs11045853",
        "call": "G|G",
        "alleles": [
          "*25",
          "*28",
          "*33"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21200595,
        "dbSnpId": "rs55901008",
        "call": "T|T",
        "alleles": [
          "*6"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21202553,
        "dbSnpId": "rs1228465562",
        "call": "T|T",
        "alleles": [
          "*36"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21202555,
        "dbSnpId": "rs59113707",
        "call": "C|C",
        "alleles": [
          "*27"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21202649,
        "dbSnpId": "rs56387224",
        "call": "A|A",
        "alleles": [
          "*7"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21202664,
        "dbSnpId": "rs142965323",
        "call": "G|G",
        "alleles": [
          "*26"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21205921,
        "dbSnpId": "rs72559748",
        "call": "A|A",
        "alleles": [
          "*8"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21205999,
        "dbSnpId": "rs59502379",
        "call": "G|G",
        "alleles": [
          "*9",
          "*31"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21239042,
        "dbSnpId": "rs34671512",
        "call": "A|A",
        "alleles": [
          "*19",
          "*20",
          "*40"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21239077,
        "dbSnpId": "rs56199088",
        "call": "A|A",
        "alleles": [
          "*10",
          "*12"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21239113,
        "dbSnpId": "rs55737008",
        "call": "A|A",
        "alleles": [
          "*11",
          "*13"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21239145,
        "dbSnpId": "rs200995543",
        "call": "C|C",
        "alleles": [
          "*34"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21239158,
        "dbSnpId": "rs140790673",
        "call": "C|C",
        "alleles": [
          "*29"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21176871,
        "dbSnpId": null,
        "call": null,
        "alleles": [
          "*38"
        ],
        "phased": false,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21176898,
        "dbSnpId": "rs77271279",
        "call": null,
        "alleles": [
          "*41"
        ],
        "phased": false,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21178612,
        "dbSnpId": "rs141467543",
        "call": null,
        "alleles": [
          "*42"
        ],
        "phased": false,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21196975,
        "dbSnpId": "rs183501729",
        "call": null,
        "alleles": [
          "*39"
        ],
        "phased": false,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21200544,
        "dbSnpId": "rs72559747",
        "call": null,
        "alleles": [
          "*47"
        ],
        "phased": false,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21206031,
        "dbSnpId": "rs74064213",
        "call": null,
        "alleles": [
          "*43",
          "*44"
        ],
        "phased": false,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "SLCO1B1",
        "chromosome": "chr12",
        "position": 21222355,
        "dbSnpId": "rs71581941",
        "call": null,
        "alleles": [
          "*45",
          "*46"
        ],
        "phased": false,
        "wildtypeAllele": "C",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": [
      "rs4149056T/rs4149056T"
    ]
  },
  {
    "geneSymbol": "TPMT",
    "chr": "chr6",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [
      {
        "rule_name": "TPMT reverse complement footnote",
        "version": "1",
        "matches": {
          "gene": "TPMT",
          "hapsCalled": [],
          "hapsMissing": [],
          "variantsMissing": [],
          "variant": "",
          "dips": [],
          "drugs": []
        },
        "exception_type": "footnote",
        "message": "The TPMT gene is on the negative chromosomal strand, all genotype calls for TPMT in this report refer to the positive chromosomal strand.  Therefore, genotype calls are complemented from gene bases."
      }
    ],
    "relatedDrugs": [
      {
        "name": "azathioprine",
        "guidelineId": "RxNorm:1256"
      },
      {
        "name": "mercaptopurine",
        "guidelineId": "RxNorm:103"
      },
      {
        "name": "thioguanine",
        "guidelineId": "RxNorm:10485"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "TPMT",
          "name": "*1",
          "function": "Normal Function",
          "reference": true
        },
        "allele2": {
          "gene": "TPMT",
          "name": "*1",
          "function": "Normal Function",
          "reference": true
        },
        "gene": "TPMT",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "Normal Metabolizer",
        "label": "*1/*1"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "TPMT",
          "name": "*1",
          "function": "Normal Function",
          "reference": true
        },
        "allele2": {
          "gene": "TPMT",
          "name": "*1",
          "function": "Normal Function",
          "reference": true
        },
        "gene": "TPMT",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "Normal Metabolizer",
        "label": "*1/*1"
      }
    ],
    "variants": [
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18130687,
        "dbSnpId": "rs1142345",
        "call": "T|T",
        "alleles": [
          "*3A",
          "*3C",
          "*41"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18130694,
        "dbSnpId": "rs150900439",
        "call": "T|T",
        "alleles": [
          "*20"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18130725,
        "dbSnpId": "rs72552736",
        "call": "A|A",
        "alleles": [
          "*7"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18130729,
        "dbSnpId": "rs139392616",
        "call": "C|C",
        "alleles": [
          "*40"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18130758,
        "dbSnpId": "rs398122996",
        "call": "A|A",
        "alleles": [
          "*37"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18130762,
        "dbSnpId": "rs56161402",
        "call": "C|C",
        "alleles": [
          "*8"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18130772,
        "dbSnpId": "rs377085266",
        "call": "A|A",
        "alleles": [
          "*25"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18130781,
        "dbSnpId": "rs1800584",
        "call": "C|C",
        "alleles": [
          "*4"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18132136,
        "dbSnpId": "rs72556347",
        "call": "A|A",
        "alleles": [
          "*26"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18132147,
        "dbSnpId": "rs79901429",
        "call": "A|A",
        "alleles": [
          "*31"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18132163,
        "dbSnpId": null,
        "call": "C|C",
        "alleles": [
          "*36"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18133845,
        "dbSnpId": "rs75543815",
        "call": "T|T",
        "alleles": [
          "*6"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18133847,
        "dbSnpId": "rs6921269",
        "call": "C|C",
        "alleles": [
          "*24"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18133870,
        "dbSnpId": "rs772832951",
        "call": "A|A",
        "alleles": [
          "*38"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18133884,
        "dbSnpId": "rs74423290",
        "call": "G|G",
        "alleles": [
          "*23"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18133887,
        "dbSnpId": "rs201695576",
        "call": "T|T",
        "alleles": [
          "*44"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18133890,
        "dbSnpId": "rs9333570",
        "call": "C|C",
        "alleles": [
          "*15"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18138969,
        "dbSnpId": "rs144041067",
        "call": "C|C",
        "alleles": [
          "*16",
          "*22"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18138970,
        "dbSnpId": "rs112339338",
        "call": "G|G",
        "alleles": [
          "*33"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18138997,
        "dbSnpId": "rs1800460",
        "call": "C|C",
        "alleles": [
          "*3A",
          "*3B"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18139027,
        "dbSnpId": "rs72552737",
        "call": "C|C",
        "alleles": [
          "*10"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18139689,
        "dbSnpId": "rs72552738",
        "call": "C|C",
        "alleles": [
          "*11"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18139710,
        "dbSnpId": "rs200220210",
        "call": "G|G",
        "alleles": [
          "*12"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18143597,
        "dbSnpId": null,
        "call": "T|T",
        "alleles": [
          "*19"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18143606,
        "dbSnpId": "rs151149760",
        "call": "T|T",
        "alleles": [
          "*9"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18143613,
        "dbSnpId": null,
        "call": "C|C",
        "alleles": [
          "*28"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18143622,
        "dbSnpId": "rs115106679",
        "call": "C|C",
        "alleles": [
          "*32"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18143643,
        "dbSnpId": null,
        "call": "A|A",
        "alleles": [
          "*27"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18143700,
        "dbSnpId": "rs753545734",
        "call": "C|C",
        "alleles": [
          "*43"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18143718,
        "dbSnpId": "rs111901354",
        "call": "G|G",
        "alleles": [
          "*34"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18143724,
        "dbSnpId": "rs1800462",
        "call": "C|C",
        "alleles": [
          "*2"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18143728,
        "dbSnpId": "rs1256618794",
        "call": "C|C",
        "alleles": [
          "*43"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18147838,
        "dbSnpId": "rs281874771",
        "call": "G|G",
        "alleles": [
          "*39"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18147845,
        "dbSnpId": "rs777686348",
        "call": "C|C",
        "alleles": [
          "*18"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18147851,
        "dbSnpId": "rs200591577",
        "call": "G|G",
        "alleles": [
          "*21"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18147856,
        "dbSnpId": null,
        "call": "A|A",
        "alleles": [
          "*35"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18147910,
        "dbSnpId": "rs72552740",
        "call": "A|A",
        "alleles": [
          "*5"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18149004,
        "dbSnpId": null,
        "call": "G|G",
        "alleles": [
          "*17"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18149022,
        "dbSnpId": "rs750424422",
        "call": "C|C",
        "alleles": [
          "*30"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18149032,
        "dbSnpId": "rs759836180",
        "call": "C|C",
        "alleles": [
          "*42"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18149045,
        "dbSnpId": "rs72552742",
        "call": "T|T",
        "alleles": [
          "*13"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18149126,
        "dbSnpId": "rs267607275",
        "call": "A|A",
        "alleles": [
          "*29"
        ],
        "phased": true,
        "wildtypeAllele": "A",
        "mismatch": false
      },
      {
        "gene": "TPMT",
        "chromosome": "chr6",
        "position": 18149127,
        "dbSnpId": "rs9333569",
        "call": "T|T",
        "alleles": [
          "*14"
        ],
        "phased": true,
        "wildtypeAllele": "T",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "UGT1A1",
    "chr": "chr2",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [
      {
        "rule_name": "UGT1A1 repeat warning",
        "version": "1",
        "matches": {
          "gene": "UGT1A1",
          "hapsCalled": [],
          "hapsMissing": [],
          "variantsMissing": [],
          "variant": "",
          "dips": [],
          "drugs": []
        },
        "exception_type": "footnote",
        "message": "Some alleles in UGT1A1 are distinguished by a repeat sequence; some genotyping technologies may not accurately call the repeat."
      }
    ],
    "relatedDrugs": [
      {
        "name": "atazanavir",
        "guidelineId": "RxNorm:343047"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "UGT1A1",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "UGT1A1",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "gene": "UGT1A1",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "Normal Metabolizer",
        "label": "*1/*1"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "UGT1A1",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "allele2": {
          "gene": "UGT1A1",
          "name": "*1",
          "function": "Normal function",
          "reference": true
        },
        "gene": "UGT1A1",
        "phenotype": "Normal Metabolizer",
        "variant": null,
        "lookupKey": "Normal Metabolizer",
        "label": "*1/*1"
      }
    ],
    "variants": [
      {
        "gene": "UGT1A1",
        "chromosome": "chr2",
        "position": 233759924,
        "dbSnpId": "rs887829",
        "call": "C|C",
        "alleles": [
          "*80",
          "*80+*28",
          "*80+*37"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      },
      {
        "gene": "UGT1A1",
        "chromosome": "chr2",
        "position": 233760233,
        "dbSnpId": "rs3064744",
        "call": "CAT|CAT",
        "alleles": [
          "*28",
          "*36",
          "*37",
          "*80+*28",
          "*80+*37"
        ],
        "phased": true,
        "wildtypeAllele": "CAT",
        "mismatch": false
      },
      {
        "gene": "UGT1A1",
        "chromosome": "chr2",
        "position": 233760498,
        "dbSnpId": "rs4148323",
        "call": "G|G",
        "alleles": [
          "*6"
        ],
        "phased": true,
        "wildtypeAllele": "G",
        "mismatch": false
      },
      {
        "gene": "UGT1A1",
        "chromosome": "chr2",
        "position": 233760973,
        "dbSnpId": "rs35350960",
        "call": "C|C",
        "alleles": [
          "*27"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": []
  },
  {
    "geneSymbol": "VKORC1",
    "chr": "chr16",
    "phased": true,
    "callSource": "MATCHER",
    "uncalledHaplotypes": [],
    "messages": [
      {
        "rule_name": "VKORC1",
        "version": "1",
        "matches": {
          "gene": "VKORC1",
          "hapsCalled": [],
          "hapsMissing": [],
          "variantsMissing": [],
          "variant": "",
          "dips": [],
          "drugs": []
        },
        "exception_type": "footnote",
        "message": "CPIC recommendations for warfarin use only rs9923231; however, other variants in VKORC1 may have functional consequences and may be more common in some populations."
      },
      {
        "rule_name": "VKORC1 reverse complement footnote",
        "version": "1",
        "matches": {
          "gene": "VKORC1",
          "hapsCalled": [],
          "hapsMissing": [],
          "variantsMissing": [],
          "variant": "",
          "dips": [],
          "drugs": []
        },
        "exception_type": "footnote",
        "message": "The VKORC1 gene is on the negative chromosomal strand, all genotype calls for VKORC1 in this report refer to the positive chromosomal strand.  Therefore, genotype calls are complemented from gene bases."
      }
    ],
    "relatedDrugs": [
      {
        "name": "warfarin",
        "guidelineId": "RxNorm:11289"
      }
    ],
    "matcherDiplotypes": [
      {
        "allele1": {
          "gene": "VKORC1",
          "name": "rs9923231 reference (C)",
          "function": null,
          "reference": true
        },
        "allele2": {
          "gene": "VKORC1",
          "name": "rs9923231 reference (C)",
          "function": null,
          "reference": true
        },
        "gene": "VKORC1",
        "phenotype": null,
        "variant": null,
        "lookupKey": null,
        "label": "rs9923231 reference (C)/rs9923231 reference (C)"
      }
    ],
    "diplotypes": [
      {
        "allele1": {
          "gene": "VKORC1",
          "name": "rs9923231 reference (C)",
          "function": null,
          "reference": true
        },
        "allele2": {
          "gene": "VKORC1",
          "name": "rs9923231 reference (C)",
          "function": null,
          "reference": true
        },
        "gene": "VKORC1",
        "phenotype": null,
        "variant": null,
        "lookupKey": null,
        "label": "rs9923231 reference (C)/rs9923231 reference (C)"
      }
    ],
    "variants": [
      {
        "gene": "VKORC1",
        "chromosome": "chr16",
        "position": 31096368,
        "dbSnpId": "rs9923231",
        "call": "C|C",
        "alleles": [
          "rs9923231 variant (T)"
        ],
        "phased": true,
        "wildtypeAllele": "C",
        "mismatch": false
      }
    ],
    "variantsOfInterest": [],
    "highlightedVariants": []
  }
]