Mercurial > repos > bimib > marea
changeset 0:23ac9cf12788 draft
Uploaded
| author | bimib |
|---|---|
| date | Tue, 06 Nov 2018 03:16:21 -0500 |
| parents | |
| children | 9e63d5f02d62 |
| files | Marea/local/HMRcoreMap.svg Marea/local/HMRcore_genes.p Marea/local/HMRcore_rules.p Marea/local/Recon_genes.p Marea/local/Recon_rules.p Marea/marea.py Marea/marea.xml Marea/marea_cluster.py Marea/marea_cluster.xml |
| diffstat | 9 files changed, 9407 insertions(+), 0 deletions(-) [+] |
line wrap: on
line diff
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/Marea/local/HMRcoreMap.svg Tue Nov 06 03:16:21 2018 -0500 @@ -0,0 +1,7702 @@ +<?xml version="1.0" encoding="UTF-8" standalone="no"?> +<!-- Generator: Adobe Illustrator 22.0.1, SVG Export Plug-In . SVG Version: 6.00 Build 0) --> + +<svg + xmlns:dc="http://purl.org/dc/elements/1.1/" + xmlns:cc="http://creativecommons.org/ns#" + xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" + xmlns:svg="http://www.w3.org/2000/svg" + xmlns="http://www.w3.org/2000/svg" + xmlns:xlink="http://www.w3.org/1999/xlink" + xmlns:sodipodi="http://sodipodi.sourceforge.net/DTD/sodipodi-0.dtd" + xmlns:inkscape="http://www.inkscape.org/namespaces/inkscape" + version="1.1" + x="0px" + y="0px" + viewBox="0 0 1904.8016 1511.2752" + xml:space="preserve" + id="svg2" + inkscape:version="0.91 r13725" + sodipodi:docname="HMRcoreMap.svg" + width="1904.8015" + height="1511.2753"><metadata + id="metadata2021"><rdf:RDF><cc:Work + rdf:about=""><dc:format>image/svg+xml</dc:format><dc:type + rdf:resource="http://purl.org/dc/dcmitype/StillImage" /><dc:title /></cc:Work></rdf:RDF></metadata><defs + id="defs2019"><sodipodi:namedview + showguides="true" + showgrid="true" + pagecolor="#ffffff" + inkscape:zoom="1.4702451" + inkscape:window-y="-8" + inkscape:window-x="-8" + inkscape:window-width="1920" + inkscape:window-maximized="1" + inkscape:window-height="1017" + inkscape:snap-page="false" + inkscape:snap-grids="true" + inkscape:pageshadow="2" + inkscape:pageopacity="0.0" + inkscape:document-units="px" + inkscape:cy="338.10986" + inkscape:cx="1343.7768" + inkscape:current-layer="layer1" + id="base" + fit-margin-top="0" + fit-margin-right="0" + fit-margin-left="0" + fit-margin-bottom="0" + borderopacity="1.0" + bordercolor="#666666"><inkscape:grid + type="xygrid" + originy="72.926308" + originx="-97.409688" + id="grid3434" + dotted="true" /></sodipodi:namedview></defs><sodipodi:namedview + pagecolor="#ffffff" + bordercolor="#666666" + borderopacity="1" + objecttolerance="10" + gridtolerance="10" + guidetolerance="10" + inkscape:pageopacity="0" + inkscape:pageshadow="2" + inkscape:window-width="1920" + inkscape:window-height="1017" + id="namedview2017" + showgrid="false" + inkscape:zoom="0.44727204" + inkscape:cx="497.63252" + inkscape:cy="796.80241" + inkscape:window-x="-8" + inkscape:window-y="-8" + inkscape:window-maximized="1" + inkscape:current-layer="svg2" + fit-margin-top="0" + fit-margin-left="0" + fit-margin-right="0" + fit-margin-bottom="0" /><style + type="text/css" + id="style4"> + .st0{display:none;} + .st1{display:inline;} + .st2{fill:none;stroke:#5AB6E7;stroke-width:7;stroke-linejoin:round;} + .st3{fill:none;stroke:#5AB6E7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:11.9422,11.9422;} + .st4{fill:none;stroke:#5AB6E7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:12.1815,12.1815;} + .st5{font-family:'Helvetica';} + .st6{font-size:30px;} + .st7{font-size:39.262px;} + .st8{fill:none;stroke:#0000FF;stroke-width:30;} + .st9{fill:none;stroke:#E41A1C;stroke-width:30;} + .st10{fill:none;stroke:#BEBEBE;stroke-width:30;} + .st11{stroke:#000000;stroke-width:30;} + .st12{fill:none;stroke:#BEBEBE;stroke-width:30;stroke-dasharray:30,30;stroke-dashoffset:6;} + .st13{fill:none;stroke:#000000;stroke-width:1.8444;} + .st14{fill:none;stroke:#000000;stroke-width:2.1821;} + .st15{font-family:'Calibri-Bold';} + .st16{font-size:16px;} + .st17{font-family:'Calibri';} + .st18{font-size:10px;} + .st19{fill:none;stroke:#000000;stroke-width:1.8856;} + .st20{fill:none;stroke:#000000;stroke-width:1.9459;} + .st21{fill:none;stroke:#000000;stroke-width:2.2892;} + .st22{fill:none;stroke:#000000;stroke-width:2.5;} + .st23{fill:none;stroke:#000000;stroke-width:1.9412;} + .st24{fill:none;stroke:#000000;stroke-width:1.9661;} + .st25{fill:none;stroke:#000000;stroke-width:1.0869;} + .st26{font-size:6.0937px;} + .st27{fill:none;stroke:#000000;stroke-width:2.0174;} + .st28{fill:none;stroke:#000000;stroke-width:1.889;} + .st29{fill:none;stroke:#000000;stroke-width:1.7769;} + .st30{fill:none;stroke:#000000;stroke-width:1.8717;} + .st31{fill:none;stroke:#000000;stroke-width:1.6971;} + .st32{fill:none;stroke:#000000;stroke-width:2.4492;} + .st33{fill:none;stroke:#000000;stroke-width:2.0366;} + .st34{fill:none;stroke:#000000;stroke-width:1.5903;} + .st35{fill:none;stroke:#000000;stroke-width:1.7287;} + .st36{fill:none;stroke:#000000;stroke-width:1.7741;} + .st37{fill:none;stroke:#000000;stroke-width:2.2309;} + .st38{font-size:14px;} + .st39{fill:none;stroke:#000000;stroke-width:1.7752;} + .st40{font-size:9.75px;} + .st41{fill:none;stroke:#000000;stroke-width:1.8816;} + .st42{fill:none;stroke:#000000;stroke-width:1.8615;} + .st43{fill:none;stroke:#000000;stroke-width:1.7923;} + .st44{fill:none;stroke:#000000;stroke-width:1.8691;} + .st45{fill:none;stroke:#000000;stroke-width:2.823;} + .st46{fill:none;stroke:#000000;stroke-width:2.3556;} + .st47{fill:none;stroke:#000000;stroke-width:2.0484;} + .st48{fill:none;stroke:#000000;stroke-width:1.127;} + .st49{fill:none;stroke:#000000;stroke-width:1.5383;} + .st50{fill:none;stroke:#000000;stroke-width:1.4921;} + .st51{fill:none;stroke:#000000;stroke-width:1.4117;} + .st52{fill:none;stroke:#000000;stroke-width:1.3787;} + .st53{fill:none;stroke:#000000;stroke-width:2.2437;} + .st54{fill:none;stroke:#000000;stroke-width:1.8492;} + .st55{fill:none;stroke:#000000;stroke-width:1.816;} + .st56{fill:none;stroke:#000000;stroke-width:2.0159;} + .st57{fill:none;stroke:#000000;stroke-width:2.0089;} + .st58{fill:none;stroke:#000000;stroke-width:1.2666;} + .st59{fill:none;stroke:#000000;stroke-width:1.3186;} + .st60{fill:none;stroke:#000000;stroke-width:1.2211;} + .st61{fill:none;stroke:#000000;stroke-width:1.1828;} + .st62{fill:none;stroke:#000000;stroke-width:2.0699;} + .st63{fill:none;stroke:#000000;stroke-width:2.1781;} + .st64{fill:none;stroke:#000000;stroke-width:2.6751;} + .st65{fill:none;stroke:#000000;stroke-width:3.1636;} + .st66{fill:none;stroke:#000000;stroke-width:3.3699;} + .st67{fill:none;stroke:#000000;stroke-width:2.3147;} + .st68{fill:none;stroke:#000000;stroke-width:2.2203;} + .st69{fill:none;stroke:#000000;stroke-width:2.2293;} + .st70{fill:none;stroke:#000000;stroke-width:1.9667;} + .st71{fill:none;stroke:#000000;stroke-width:2.1341;} + .st72{fill:none;stroke:#000000;stroke-width:1.5819;} + .st73{fill:none;stroke:#000000;stroke-width:2.0995;} + .st74{fill:none;stroke:#000000;stroke-width:2.4348;} + .st75{fill:none;stroke:#000000;stroke-width:2.3313;} + .st76{fill:none;stroke:#000000;stroke-width:2.0948;} + .st77{fill:none;stroke:#000000;stroke-width:2.2352;} + .st78{fill:none;stroke:#000000;stroke-width:2.3817;} + .st79{fill:none;stroke:#000000;stroke-width:2.2976;} + .st80{fill:none;stroke:#000000;stroke-width:2.0951;} + .st81{fill:none;stroke:#231F20;stroke-width:7;stroke-linejoin:round;stroke-miterlimit:2;} + .st82{fill:none;stroke:#000000;stroke-width:1.3247;} + .st83{fill:none;stroke:#000000;stroke-width:1.564;} + .st84{fill:none;stroke:#000000;stroke-width:2.1156;} + .st85{fill:none;stroke:#000000;stroke-width:1.3926;} + .st86{fill:none;stroke:#000000;stroke-width:1.123;} + .st87{font-size:9.7577px;} + .st88{font-size:15.6123px;} + .st89{fill:none;stroke:#000000;stroke-width:2.0926;} + .st90{fill:none;stroke:#000000;stroke-width:1.7671;} + .st91{fill:none;stroke:#000000;stroke-width:1.7901;} + .st92{fill:none;stroke:#000000;stroke-width:1.9212;} + .st93{fill:none;stroke:#000000;stroke-width:1.3319;} + .st94{fill:none;stroke:#000000;stroke-width:2.1398;} + .st95{fill:none;stroke:#000000;stroke-width:1.3641;} + .st96{fill:none;stroke:#000000;stroke-width:2.216;} + .st97{fill:none;stroke:#000000;stroke-width:2.341;} + .st98{fill:none;stroke:#000000;stroke-width:1.2412;} + .st99{fill:none;stroke:#000000;stroke-width:1.7827;} + .st100{fill:none;stroke:#000000;stroke-width:1.8658;} + .st101{fill:none;stroke:#000000;stroke-width:2.4932;} + .st102{fill:none;stroke:#000000;stroke-width:2.489;} + .st103{fill:none;stroke:#000000;stroke-width:2.5188;} + .st104{fill:none;stroke:#000000;stroke-width:2.4962;} + .st105{fill:none;stroke:#000000;stroke-width:1.6791;} + .st106{fill:none;stroke:#000000;stroke-width:1.8121;} + .st107{fill:none;stroke:#000000;stroke-width:1.5802;} + .st108{fill:none;stroke:#000000;stroke-width:1.5346;} + .st109{fill:none;stroke:#000000;stroke-width:1.8293;} + .st110{fill:none;stroke:#000000;stroke-width:1.6126;} + .st111{fill:none;stroke:#000000;stroke-width:2.5434;} + .st112{fill:none;stroke:#000000;stroke-width:1.7519;} + .st113{fill:none;stroke:#000000;stroke-width:1.5283;} + .st114{fill:none;stroke:#000000;stroke-width:1.8016;} + .st115{fill:none;stroke:#000000;stroke-width:3.1376;} + .st116{fill:none;stroke:#000000;stroke-width:1.8065;} + .st117{fill:none;stroke:#000000;stroke-width:2.1653;} + .st118{fill:none;stroke:#000000;stroke-width:1.5857;} + .st119{fill:none;stroke:#000000;stroke-width:2.1349;} + .st120{fill:none;stroke:#000000;stroke-width:2.3204;} + .st121{fill:none;stroke:#000000;stroke-width:1.6814;} + .st122{fill:none;stroke:#000000;stroke-width:2.9048;} + .st123{fill:none;stroke:#000000;stroke-width:2.2582;} + .st124{fill:none;stroke:#000000;stroke-width:1.9206;} + .st125{fill:none;stroke:#000000;stroke-width:2.0975;} + .st126{fill:none;stroke:#000000;stroke-width:1.1759;} + .st127{fill:none;stroke:#000000;stroke-width:1.1348;} + .st128{fill:none;stroke:#000000;stroke-width:2.0031;} + .st129{fill:none;stroke:#000000;stroke-width:1.966;} + .st130{fill:none;stroke:#000000;stroke-width:1.822;} + .st131{fill:none;stroke:#000000;stroke-width:2.3785;} + .st132{fill:none;stroke:#000000;stroke-width:1.5336;} + .st133{fill:none;stroke:#000000;stroke-width:1.4989;} + .st134{fill:none;stroke:#000000;stroke-width:1.8163;} + .st135{fill:none;stroke:#000000;stroke-width:2.0955;} + .st136{fill:none;stroke:#000000;stroke-width:2.1429;} + .st137{fill:none;stroke:#000000;stroke-width:2.1034;} + .st138{fill:none;stroke:#000000;stroke-width:2.0686;} + .st139{fill:none;stroke:#000000;stroke-width:1.1187;} + .st140{fill:none;stroke:#000000;stroke-width:2.3278;} + .st141{fill:none;stroke:#000000;stroke-width:2.1814;} + .st142{fill:none;stroke:#000000;stroke-width:2.0648;} + .st143{fill:none;stroke:#000000;stroke-width:2.5236;} + .st144{fill:none;stroke:#000000;stroke-width:2.5697;} + .st145{fill:#786721;stroke:#000000;stroke-width:2.5;} + .st146{fill:none;stroke:#000000;stroke-width:1.4509;} + .st147{fill:none;stroke:#000000;stroke-width:1.7529;} + .st148{fill:none;stroke:#000000;stroke-width:1.9252;} + .st149{fill:none;stroke:#000000;stroke-width:1.8983;} + .st150{fill:none;stroke:#000000;stroke-width:1.7735;} + .st151{fill:none;stroke:#000000;stroke-width:1.5537;} + .st152{fill:none;stroke:#000000;stroke-width:1.7117;} + .st153{fill:none;stroke:#000000;stroke-width:1.7429;} + .st154{fill:none;stroke:#000000;stroke-width:1.639;} + .st155{fill:none;stroke:#000000;stroke-width:2.4155;} + .st156{fill:none;stroke:#000000;stroke-width:1.9672;} + .st157{fill:none;stroke:#000000;stroke-width:2.2231;} + .st158{fill:none;stroke:#000000;stroke-width:1.8337;} + .st159{fill:none;stroke:#000000;stroke-width:1.8531;} + .st160{fill:none;stroke:#000000;stroke-width:2.2256;} + .st161{fill:none;stroke:#000000;stroke-width:2.0666;} + .st162{fill:none;stroke:#000000;stroke-width:1.7335;} + .st163{fill:none;stroke:#000000;stroke-width:1.6847;} + .st164{fill:none;stroke:#000000;stroke-width:2.4884;} + .st165{fill:none;stroke:#000000;stroke-width:2.3113;} + .st166{fill:none;stroke:#000000;stroke-width:2.1555;} + .st167{fill:none;stroke:#000000;stroke-width:1.9909;} + .st168{fill:none;stroke:#000000;stroke-width:9.2205;stroke-linecap:round;stroke-linejoin:round;stroke-miterlimit:2;} + .st169{fill:none;stroke:#000000;stroke-width:2.5668;} + .st170{fill:none;stroke:#000000;stroke-width:1.9328;} + .st171{fill:none;stroke:#000000;stroke-width:3.1971;} + .st172{fill:none;stroke:#000000;stroke-width:3.1373;} + .st173{font-size:6.5px;} +</style><g + id="Layer_2" + transform="translate(-20.6,18.418554)"><g + id="rect3188_1_" + class="st0" + style="display:none"><g + class="st1" + id="g8" + style="display:inline"><polyline + class="st2" + points="269.1,669.8 269.1,663.8 275.1,663.8 " + id="polyline10" + style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round" /><line + class="st3" + x1="287" + y1="663.79999" + x2="1475.2" + y2="663.79999" + id="line12" + style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:11.9422, 11.9422" /><polyline + class="st2" + points="1481.2,663.8 1487.2,663.8 1487.2,669.8 " + id="polyline14" + style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round" /><line + class="st4" + x1="1487.2" + y1="682" + x2="1487.2" + y2="1138.8" + id="line16" + style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:12.1815, 12.1815" /><polyline + class="st2" + points="1487.2,1144.9 1487.2,1150.9 1481.2,1150.9 " + id="polyline18" + style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round" /><line + class="st3" + x1="1469.3" + y1="1150.9" + x2="281" + y2="1150.9" + id="line20" + style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:11.9422, 11.9422" /><polyline + class="st2" + points="275.1,1150.9 269.1,1150.9 269.1,1144.9 " + id="polyline22" + style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round" /><line + class="st4" + x1="269.10001" + y1="1132.7" + x2="269.10001" + y2="675.90002" + id="line24" + style="fill:none;stroke:#5ab6e7;stroke-width:7;stroke-linejoin:round;stroke-dasharray:12.1815, 12.1815" /></g></g></g><g + id="flowRoot3336" + transform="translate(-20.6,18.418554)" /><g + id="flowRoot16808" + transform="translate(-20.6,18.418554)" /><g + id="flowRoot2749" + transform="translate(-20.6,18.418554)" /><g + id="flowRoot3621" + transform="translate(-20.6,18.418554)" /><g + id="flowRoot1974" + transform="translate(-20.6,18.418554)" /><text + style="font-size:30px;font-family:Helvetica" + id="text35" + class="st5 st6" + x="129.77209" + y="1429.6542">= Up regulated</text> +<text + style="font-size:30px;font-family:Helvetica" + id="text37" + class="st5 st6" + x="129.77209" + y="1504.6542">= Down regulated</text> +<text + style="font-size:39.26200104px;font-family:Helvetica" + id="text39" + class="st5 st7" + x="-1.9770008" + y="1365.1874">Legend</text> +<path + style="fill:none;stroke:#0000ff;stroke-width:30" + d="m 0,1495.6186 112,0" + class="st8" + inkscape:connector-curvature="0" + id="path6613-3" /><path + style="fill:none;stroke:#e41a1c;stroke-width:30" + d="m 0,1420.7186 112,0" + class="st9" + inkscape:connector-curvature="0" + id="path6613-8-6" /><path + style="fill:none;stroke:#bebebe;stroke-width:30" + d="m 503.8,1492.0186 112,0" + class="st10" + inkscape:connector-curvature="0" + id="path6613-8-1-0" /><path + style="stroke:#000000;stroke-width:30" + d="m 1140.7,1415.1186 112,0" + class="st11" + inkscape:connector-curvature="0" + id="path6613-8-4-9" /><path + style="fill:none;stroke:#bebebe;stroke-width:30;stroke-dasharray:30, 30;stroke-dashoffset:6" + d="m 503.8,1417.3186 112,0" + class="st12" + inkscape:connector-curvature="0" + id="path6613-8-2-6" /><text + style="font-size:30px;font-family:Helvetica" + id="text46" + class="st5 st6" + x="1270.1295" + y="1423.1249">= Not classified</text> +<text + style="font-size:30px;font-family:Helvetica" + id="text48" + class="st5 st6" + x="631.3902" + y="1426.3895">= Not significant</text> +<text + style="font-size:30px;font-family:Helvetica" + id="text50" + class="st5 st6" + x="631.3902" + y="1501.3895">= Fold change under threshold</text> +<text + style="font-size:30px;font-family:Helvetica" + id="text52" + class="st5 st6" + x="1139.6979" + y="1499.9501">Thickness is proportional to fold change</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.84440005" + d="m 834.5,332.71855 26.9,-0.1 m -18,-9 c -2.8,5.8 3.1,9.6 3.1,9.6 m 3.1,-0.5 c 5.1,-0.7 4.9,-9.1 4.9,-9.1" + class="st13" + inkscape:label="CMPK1_DTYMK" + inkscape:connector-curvature="0" + id="R_CMPK1_DTYMK" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 464.9,461.41855 c 2.2,-7.3 2.2,-7.3 2.2,-7.3 l 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" + class="st14" + inkscape:label="backward PGM" + inkscape:connector-curvature="0" + id="B_PGAM2_PGAM1_BPGM_PGAM4_1" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text56" + class="st15 st16" + x="449.63071" + y="207.37375">F6P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text58" + class="st15 st16" + x="443.9202" + y="262.58224">F16BP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text60" + class="st15 st16" + x="446.7605" + y="320.19556">GA3P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text62" + class="st15 st16" + x="435.38208" + y="383.34305">1,3BPGA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text64" + class="st15 st16" + x="453.15561" + y="449.14966">3PG</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text66" + class="st15 st16" + x="449.81769" + y="507.42996">2PG</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text68" + class="st15 st16" + x="453.76788" + y="562.48846">PEP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text70" + class="st15 st16" + x="456.6004" + y="614.97485">Pyr</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text72" + class="st15 st16" + x="349.18579" + y="614.4632">Lact</text> +<text + style="font-size:10px;font-family:Calibri" + id="text74" + class="st17 st18" + x="483.3494" + y="222.37965">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text76" + class="st17 st18" + x="484.75418" + y="235.29225">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text78" + class="st17 st18" + x="478.8587" + y="337.66135">NAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text80" + class="st17 st18" + x="497.25217" + y="337.66135">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text82" + class="st17 st18" + x="502.2327" + y="337.66135">Pi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text84" + class="st17 st18" + x="481.2063" + y="350.90945">NADH+H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text86" + class="st17 st18" + x="481.4881" + y="401.51096">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text88" + class="st17 st18" + x="482.81668" + y="413.79224">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text90" + class="st17 st18" + x="481.35968" + y="575.7132">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text92" + class="st17 st18" + x="485.36938" + y="586.74536">ATP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 460,182.91855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" + class="st14" + inkscape:label="forward GPI " + inkscape:connector-curvature="0" + id="F_GPI" /><path + style="fill:none;stroke:#000000;stroke-width:1.88559997" + d="m 462.1,159.61855 c 0,23.8 0,23.8 0,23.8" + class="st19" + inkscape:label="GPI " + inkscape:connector-curvature="0" + id="R_GPI" /><path + style="fill:none;stroke:#000000;stroke-width:1.94589996" + d="m 467.2,458.91855 c 0,25.4 0,25.4 0,25.4" + class="st20" + inkscape:label="phosphoglycerate mutase" + inkscape:connector-curvature="0" + id="R_PGAM2_PGAM1_BPGM_PGAM4_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 465.1,482.61855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" + class="st14" + inkscape:label="forward PGM" + inkscape:connector-curvature="0" + id="F_PGAM2_PGAM1_BPGM_PGAM4_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 464.9,516.91855 c 2.2,-7.3 2.2,-7.3 2.2,-7.3 l 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" + class="st14" + inkscape:label="backward enolase" + inkscape:connector-curvature="0" + id="B_ENO1_ENO3_ENO2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text99" + class="st15 st16" + x="492.44656" + y="284.29803">DHAP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.28920007" + d="m 462.7,265.81855 c 0,31.9 0,31.9 0,31.9 m 0.6,-17.7 20.2,0" + class="st21" + inkscape:connector-curvature="0" + id="R_ALDOC_ALDOB_ALDOA_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 482.4,278.01855 c 6.1,2.2 6.1,2.2 6.1,2.2 l -6.1,2.2 1.5,-2.2 -1.5,-2.2 z m -21.6,17.9 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" + class="st22" + inkscape:connector-curvature="0" + id="F_ALDOC_ALDOB_ALDOA_2" /><path + style="fill:none;stroke:#000000;stroke-width:1.94120002" + d="m 503.2,293.81855 2.4,-4 0.8,-1.3 -4.9,2.1 1.9,0.6 -0.2,2.6 z" + class="st23" + sodipodi:nodetypes="cccccc" + inkscape:label="backward TPI1_TPI1P2 " + inkscape:connector-curvature="0" + id="B_TPI1_TPI1P2" /><path + style="fill:none;stroke:#000000;stroke-width:1.96609998" + d="m 488.7,300.71855 c -3.2,5.4 -3.2,5.4 -3.2,5.4 l 5,-2.3 -1.9,-0.6 0.1,-2.5 z" + class="st24" + inkscape:label="forwardTPI1_TPI1P2 " + inkscape:connector-curvature="0" + id="F_TPI1_TPI1P2" /><path + style="fill:none;stroke:#000000;stroke-width:1.0869" + d="m 502.6,291.71855 -14.9,13" + class="st25" + inkscape:label="TPI1_TPI1P2 " + inkscape:connector-curvature="0" + id="R_TPI1_TPI1P2" /><text + style="font-size:10px;font-family:Calibri" + id="text106" + class="st17 st18" + x="485.7688" + y="533.16919">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text108" + class="st17 st26" + x="491.9993" + y="535.16919">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text110" + class="st17 st18" + x="495.08768" + y="533.16919">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text112" + class="st17 st18" + x="391.7298" + y="593.52759">NAD</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text114" + class="st15 st16" + x="532.302" + y="158.84834">6Pgl</text> +<text + style="font-size:10px;font-family:Calibri" + id="text116" + class="st17 st18" + x="471.15601" + y="174.58125">NADP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text118" + class="st15 st16" + x="598.32654" + y="159.01485">6PDG</text> +<text + style="font-size:10px;font-family:Calibri" + id="text120" + class="st17 st18" + x="627.64771" + y="176.58224">NADP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text122" + class="st15 st16" + x="694.76404" + y="159.07295">Ru5P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text124" + class="st15 st16" + x="777.18494" + y="174.95485">R5P</text> +<text + style="font-size:10px;font-family:Calibri" + id="text126" + class="st17 st18" + x="754.10773" + y="199.29225">AMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text128" + class="st17 st18" + x="760.08435" + y="185.74825">ATP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.01740003" + d="m 588.2,152.11855 c 7.3,2.2 7.3,2.2 7.3,2.2 l -7.3,2.2 1.8,-2.2 -1.8,-2.2 z" + class="st27" + inkscape:label="forward H6PD_PGLS " + inkscape:connector-curvature="0" + id="F_H6PD_PGLS" /><text + style="font-size:10px;font-family:Calibri" + id="text131" + class="st17 st18" + x="564.25323" + y="173.96214">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text133" + class="st17 st26" + x="570.4837" + y="175.96214">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text135" + class="st17 st18" + x="573.57251" + y="173.96214">O</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text137" + class="st15 st16" + x="774.87531" + y="143.11105">Xil5P</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.88900006" + d="m 814.5,167.11855 c -5.3,2.4 -5.3,2.4 -5.3,2.4 l 2.8,-4.7 0.2,2 2.3,0.3 z m -1.4,-20.6 c -2.5,-4.8 -2.5,-4.8 -2.5,-4.8 l 5.1,2.6 -2.3,0.2 -0.3,2 z" + class="st28" + inkscape:label="forward TKTL1_TKTL2_TKT_2" + inkscape:connector-curvature="0" + id="F_TKTL1_TKTL2_TKT_2" /><path + style="fill:none;stroke:#000000;stroke-width:1.88900006" + d="m 834,143.41855 c 5.2,-2.5 5.2,-2.5 5.2,-2.5 l -2.6,4.7 -0.3,-2 -2.3,-0.2 z m 3.8,21.6 c 2.6,4.8 2.6,4.8 2.6,4.8 l -5.2,-2.6 2.3,-0.2 0.3,-2 z" + class="st28" + inkscape:label="backward TKTL1_TKTL2_TKT_2 " + inkscape:connector-curvature="0" + id="B_TKTL1_TKTL2_TKT_2" /><path + style="fill:none;stroke:#000000;stroke-width:1.77690005" + d="m 813,144.01855 23.9,22.6 0,0 m -24.8,0.5 23.9,-22.6" + class="st29" + inkscape:label="TKTL1_TKTL2_TKT_2 " + inkscape:connector-curvature="0" + id="R_TKTL1_TKTL2_TKT_2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text142" + class="st15 st16" + x="842.75421" + y="140.81226">Sed7P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text144" + class="st15 st16" + x="844.42902" + y="174.28685">GA3P</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 890,164.31855 c -5.3,2.3 -5.3,2.3 -5.3,2.3 l 2.8,-4.5 0.2,2 2.3,0.2 z m -1.4,-20.1 c -2.5,-4.7 -2.5,-4.7 -2.5,-4.7 l 5.1,2.6 -2.3,0.1 -0.3,2 z" + class="st30" + inkscape:label="backward TALDO1 " + inkscape:connector-curvature="0" + id="B_TALDO1" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 912.3,141.61855 c 5.2,-2.4 5.2,-2.4 5.2,-2.4 l -2.7,4.6 -0.3,-2 -2.2,-0.2 z m 3.9,21.1 c 2.6,4.6 2.6,4.6 2.6,4.6 l -5.2,-2.5 2.3,-0.2 0.3,-1.9 z" + class="st30" + inkscape:label="forward TALDO1 " + inkscape:connector-curvature="0" + id="F_TALDO1" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 888.1,141.41855 26.3,22.8 0,0 m -27.2,0.6 26.3,-22.8" + class="st30" + inkscape:label="TALDO1 " + inkscape:connector-curvature="0" + id="R_TALDO1" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text149" + class="st15 st16" + x="922.31085" + y="174.11154">Ery4P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text151" + class="st15 st16" + x="921.73865" + y="140.67255">F6P</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.69710004" + d="m 967.5,191.21855 c -5.2,1.9 -5.2,1.9 -5.2,1.9 l 2.7,-3.8 0.2,1.7 2.3,0.2 z m -1.3,-16.9 c -2.4,-3.9 -2.4,-3.9 -2.4,-3.9 l 5,2.2 -2.2,0.1 -0.4,1.6 z" + class="st31" + inkscape:label="forward TKTL1_TKTL2_TKT_1 " + inkscape:connector-curvature="0" + id="F_TKTL1_TKTL2_TKT_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.69710004" + d="m 989.2,172.21855 c 5.1,-2 5.1,-2 5.1,-2 l -2.6,3.9 -0.3,-1.7 -2.2,-0.2 z m 3.8,17.8 c 2.5,3.9 2.5,3.9 2.5,3.9 l -5.1,-2.1 2.2,-0.2 0.4,-1.6 z" + class="st31" + inkscape:label="backward TKTL1_TKTL2_TKT_1 " + inkscape:connector-curvature="0" + id="B_TKTL1_TKTL2_TKT_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.69710004" + d="m 965.6,172.01855 25.6,19.2 0,0 m -26.5,0.5 25.6,-19.2" + class="st31" + inkscape:label="TKTL1_TKTL2_TKT_1 " + inkscape:connector-curvature="0" + id="R_TKTL1_TKTL2_TKT_1" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text156" + class="st15 st16" + x="997.87823" + y="172.36835">GA3P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text158" + class="st15 st16" + x="998.20343" + y="200.00905">F6P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text160" + class="st15 st16" + x="924.83331" + y="199.35765">Xil5P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text162" + class="st15 st16" + x="899.55011" + y="119.60376">Sed1,7BP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text164" + class="st17 st18" + x="862.2395" + y="101.52756">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text166" + class="st17 st18" + x="878.388" + y="101.37626">ADP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 974.2,113.01855 c -7.1,2.6 -7.1,2.6 -7.1,2.6 l 7.3,1.8 -2,-2 1.8,-2.4 z" + class="st32" + inkscape:label="forward ALDOC_ALDOB_ALDOA_1 " + inkscape:connector-curvature="0" + id="F_ALDOC_ALDOB_ALDOA_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.84440005" + d="m 988.6,115.41855 0,13.6 m -16.1,-13.5 32.6,0" + class="st13" + inkscape:connector-curvature="0" + id="R_ALDOC_ALDOB_ALDOA_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.03660011" + d="m 990.5,127.81855 c -1.7,5.4 -1.7,5.4 -1.7,5.4 l -2.2,-5.2 2,1.3 1.9,-1.5 z m 13.7,-14.3 c 6.9,2.2 6.9,2.2 6.9,2.2 l -6.9,2.2 1.7,-2.2 -1.7,-2.2 z" + class="st33" + inkscape:label="B ALDOC_ALDOB_ALDOA_1" + inkscape:connector-curvature="0" + id="B_ALDOC_ALDOB_ALDOA_1" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text171" + class="st15 st16" + x="1014.1517" + y="119.70486">Ery4P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text173" + class="st15 st16" + x="968.1048" + y="145.78055">DHAP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text175" + class="st15 st16" + x="771.2854" + y="226.97975">PRPP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text177" + class="st17 st18" + x="826.94464" + y="243.12035">Gly</text> +<text + style="font-size:10px;font-family:Calibri" + id="text179" + class="st17 st18" + x="913.92413" + y="243.37524">2 10-forTHF</text> +<text + style="font-size:10px;font-family:Calibri" + id="text181" + class="st17 st18" + x="857.57452" + y="209.29074">2 THF</text> +<text + style="font-size:10px;font-family:Calibri" + id="text183" + class="st17 st18" + x="884.82159" + y="209.54565">PPi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text185" + class="st17 st18" + x="901.06671" + y="208.81564">4 ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text187" + class="st17 st18" + x="836.94171" + y="209.48065">Fum</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text189" + class="st15 st16" + x="1001.889" + y="227.94115">IMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text191" + class="st17 st18" + x="802.77081" + y="243.09105">2 Gln</text> +<text + style="font-size:10px;font-family:Calibri" + id="text193" + class="st17 st18" + x="812.37921" + y="209.35135">2 Glu</text> +<text + style="font-size:10px;font-family:Calibri" + id="text195" + class="st17 st18" + x="890.34705" + y="243.16335">4 ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text197" + class="st17 st18" + x="868.02661" + y="242.86446">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text199" + class="st17 st26" + x="874.25714" + y="244.86446">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text201" + class="st17 st18" + x="877.34601" + y="242.86446">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text203" + class="st17 st18" + x="964.69855" + y="243.09105">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text205" + class="st17 st26" + x="976.56384" + y="245.09105">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text207" + class="st15 st16" + x="1268.7963" + y="274.35965">GDP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text209" + class="st17 st18" + x="1227.5297" + y="295.81955">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text211" + class="st17 st18" + x="1245.308" + y="295.39575">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text213" + class="st17 st18" + x="588.70343" + y="538.1087">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text215" + class="st17 st18" + x="593.98761" + y="501.60864">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text217" + class="st17 st18" + x="617.54913" + y="538.3645">CoA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text219" + class="st15 st16" + x="663.85974" + y="522.77277">AcCoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text221" + class="st17 st18" + x="631.93585" + y="501.30786">OAA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text223" + class="st15 st16" + x="1047.556" + y="522.03638">ippPP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text225" + class="st15 st16" + x="1123.9662" + y="522.45044">fPP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text227" + class="st15 st16" + x="1293.7357" + y="521.42017">Chol</text> +<text + style="font-size:10px;font-family:Calibri" + id="text229" + class="st17 st18" + x="715.52472" + y="482.08426">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text231" + class="st17 st18" + x="735.80505" + y="481.85086">HCO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text233" + class="st17 st26" + x="753.9007" + y="483.85086">3</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text235" + class="st17 st26" + x="756.98865" + y="476.35086">-</text> +<text + style="font-size:10px;font-family:Calibri" + id="text237" + class="st17 st18" + x="763.59314" + y="481.23465">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text239" + class="st17 st18" + x="727.01691" + y="449.72195">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text241" + class="st17 st18" + x="766.38605" + y="449.12424">Pi</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text243" + class="st15 st16" + x="790.05304" + y="468.83524">MalCoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text245" + class="st17 st18" + x="882.31775" + y="413.45636">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text247" + class="st17 st26" + x="894.18292" + y="415.45636">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text249" + class="st15 st16" + x="914.74835" + y="432.96216">AcAcACP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text251" + class="st17 st18" + x="999.9397" + y="447.29025">14NADPH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text253" + class="st17 st18" + x="1008.5541" + y="412.44064">14NADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text255" + class="st17 st18" + x="1071.347" + y="412.67795">6 H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text257" + class="st17 st26" + x="1084.9066" + y="414.67795">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text259" + class="st17 st18" + x="1087.9945" + y="412.67795">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text261" + class="st17 st18" + x="1045.3734" + y="412.36255">6 CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text263" + class="st17 st26" + x="1064.5677" + y="414.36255">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text265" + class="st15 st16" + x="1105.4926" + y="433.46994">Palm</text> +<text + style="font-size:10px;font-family:Calibri" + id="text267" + class="st17 st18" + x="949.78149" + y="447.81464">6 MalACP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text269" + class="st17 st18" + x="982.41632" + y="413.04025">7 ACP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text271" + class="st17 st18" + x="857.53351" + y="449.55005">CoA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text273" + class="st15 st16" + x="887.2757" + y="468.92606">MalACP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text275" + class="st17 st18" + x="848.5813" + y="482.83524">ACP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text277" + class="st17 st18" + x="756.85382" + y="411.64575">CoA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text279" + class="st15 st16" + x="791.37335" + y="434.89474">AcACP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text281" + class="st17 st18" + x="747.01202" + y="447.85574">ACP</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.59029996" + d="m 761,430.21855 c -5.4,1.2 -4.9,10.4 -4.9,10.4 m 4.5,-10.5 c 5.3,-1 4,-9.8 4,-9.8 m -64.6,89 0.4,-79.2 79.6,0" + class="st34" + inkscape:connector-curvature="0" + id="R_FASN_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.72870004" + d="m 855.7,430.31855 c 6.2,-0.4 7.2,-8.3 7.2,-8.3 m 28,33.5 -10,-25.7 m -45.2,0.4 68.9,-0.3 m -20.5,0.2 c 6.1,-0.6 6.4,-8.5 6.4,-8.5" + class="st35" + inkscape:connector-curvature="0" + id="R_AcAcACPSynthesis" /><text + style="font-size:10px;font-family:Calibri" + id="text285" + class="st17 st18" + x="855.91821" + y="414.73166">ACP</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.77409995" + d="m 729.6,464.51855 c -6,1.1 -5.5,9.1 -5.5,9.1 m 5.8,-9.3 c 5.9,-0.9 4.4,-8.8 4.4,-8.8 m 30.6,8.8 c 5.9,-0.9 4.4,-8.8 4.4,-8.8 m -59.2,8.5 25.7,0.6 44.2,-0.3 m -28,0.2 c -6,1.1 -5.5,9.1 -5.5,9.1 m 25.5,-9.1 c -6,1.1 -5.5,9.1 -5.5,9.1 m -56.2,37.3 0,-47.7" + class="st36" + inkscape:label="ACACB_PRKAG2_PRKAB2_ACACA_PRKAA2" + inkscape:connector-curvature="0" + id="R_ACACB_PRKAG2_PRKAB2_ACACA_PRKAA2" /><path + style="fill:none;stroke:#000000;stroke-width:2.23090005" + d="m 1428,1116.5186 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z m 57.5,-14.1 c 1.8,-5.9 1.8,-5.9 1.8,-5.9 l 2.5,5.6 -2.3,-1.3 -2,1.6 z" + class="st37" + inkscape:connector-curvature="0" + id="F_ALDH3B1_ALDH3A1_ALDH3B2_ALDH1A3" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1499.2,1027.2186 -73.8,0 0,0 m 21.8,0 c -5.9,-1.6 -4.4,-14.8 -4.4,-14.8 m 43.4,14.6 c 4.7,-3.6 3.8,-14.7 1.1,-14.6" + class="st32" + inkscape:connector-curvature="0" + id="R_SLC25A3" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text290" + class="st15 st16" + x="1480.8578" + y="1008.175">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text292" + class="st15 st16" + x="1501.9437" + y="1029.9797">Pi</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text294" + class="st15 st16" + x="1438.8285" + y="1005.4563">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text296" + class="st15 st16" + x="1401.4027" + y="1030.7034">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.23090005" + d="m 1425.9,1028.9186 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z m 14.4,-15.2 c 2.4,-5.7 2.4,-5.7 2.4,-5.7 l 2,5.8 -2.1,-1.5 -2.3,1.4 z" + class="st37" + inkscape:connector-curvature="0" + id="F_SLC25A3" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1502.9,1072.8186 c -24.6,0 -49.2,0 -73.8,0 m 21.8,0 c -3.5,-1 -4.2,-5.1 -4.5,-8.3 -0.2,-2 -0.1,-3.9 0.1,-5.9 m 43,14 c 0.4,-4.6 2.5,-9 2.7,-13.7 0,-0.4 -0.1,-1.1 -0.7,-1.1" + class="st32" + inkscape:connector-curvature="0" + id="R_SLC25A5_SLC25A4_SLC25A6" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text300" + class="st15 st16" + x="1479.5199" + y="1049.1731">ATP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text302" + class="st15 st16" + x="1511.3929" + y="1077.179">ADP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text304" + class="st15 st16" + x="1432.8539" + y="1049.8508">ATP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text306" + class="st15 st16" + x="1391.6039" + y="1077.1125">ADP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.23090005" + d="m 1429.5,1074.5186 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z m 61,-14.2 c 2.1,-5.8 2.1,-5.8 2.1,-5.8 l 2.2,5.7 -2.2,-1.4 -2.1,1.5 z" + class="st37" + inkscape:label="#F_SLC25A5_SLC25A4_SLC25A6" + inkscape:connector-curvature="0" + id="F_SLC25A5_SLC25A4_SLC25A6" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1501.4,1114.8186 -73.8,0 0,0 m 21.8,0 c -5.9,-1.4 -4.4,-13.5 -4.4,-13.5 m 41.7,-1 c 3.2,6.1 -5.5,14.6 -5.5,14.6" + class="st32" + inkscape:connector-curvature="0" + id="R_ALDH3B1_ALDH3A1_ALDH3B2_ALDH1A3" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text310" + class="st15 st38" + x="1473.5541" + y="1092.8215">GTP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text312" + class="st15 st16" + x="1509.8929" + y="1117.5793">GDP</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text314" + class="st15 st38" + x="1428.8754" + y="1092.8958">GTP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text316" + class="st15 st16" + x="1390.0355" + y="1119.3235">GDP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.23090005" + d="m 1500.2,1112.5186 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z m -57.8,-10.4 c 2.4,-5.7 2.4,-5.7 2.4,-5.7 l 2,5.8 -2.1,-1.5 -2.3,1.4 z" + class="st37" + inkscape:connector-curvature="0" + id="B_ALDH3B1_ALDH3A1_ALDH3B2_ALDH1A3" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1442.3,832.21855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" + class="st32" + inkscape:label="forward AQP8 " + inkscape:connector-curvature="0" + id="F_AQP8" /><path + style="fill:none;stroke:#000000;stroke-width:1.77520001" + d="m 1493,830.41855 -50.4,0 0,0" + class="st39" + inkscape:label="AQP8 " + inkscape:connector-curvature="0" + id="R_AQP8" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1489,828.11855 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" + class="st32" + inkscape:transform-center-y="2.6134784" + inkscape:transform-center-x="-0.38596577" + inkscape:label="backward AQP8 " + inkscape:connector-curvature="0" + id="B_AQP8" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text322" + class="st15 st16" + x="1501.9828" + y="834.84888">H</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text324" + class="st15 st40" + x="1512.0765" + y="838.04907">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text326" + class="st15 st16" + x="1517.0179" + y="834.84888">O</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text328" + class="st15 st16" + x="1405.2406" + y="834.85181">H</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text330" + class="st15 st40" + x="1415.3344" + y="838.052">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text332" + class="st15 st16" + x="1420.2758" + y="834.85181">O</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text334" + class="st15 st16" + x="1501.2924" + y="920.34888">O</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text336" + class="st15 st40" + x="1512.1127" + y="923.54907">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text338" + class="st15 st16" + x="1414.5111" + y="921.31366">O</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text340" + class="st15 st40" + x="1425.3314" + y="924.51385">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text342" + class="st15 st16" + x="1500.6859" + y="857.42798">CO</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text344" + class="st15 st40" + x="1519.8578" + y="860.6272">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text346" + class="st15 st16" + x="1405.0785" + y="858.29315">CO</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text348" + class="st15 st40" + x="1424.2504" + y="861.49341">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text350" + class="st15 st16" + x="1500.932" + y="879.84888">CoA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text352" + class="st15 st16" + x="1400.6957" + y="879.69458">CoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1441.9,917.71855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" + class="st32" + inkscape:label="TransportOxygen F" + inkscape:connector-curvature="0" + id="F_TransportOxygen" /><path + style="fill:none;stroke:#000000;stroke-width:1.88160002" + d="m 1497.8,915.91855 -56.7,0 0,0" + class="st41" + inkscape:label="TransportOxygen" + inkscape:connector-curvature="0" + id="R_TransportOxygen" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1440.8,854.71855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" + class="st32" + inkscape:label="forward Transport_CO2 " + inkscape:connector-curvature="0" + id="F_Transport_CO2" /><path + style="fill:none;stroke:#000000;stroke-width:1.86150002" + d="m 1493.5,852.91855 -55.5,0 0,0" + class="st42" + inkscape:label="Transport_CO2 " + inkscape:connector-curvature="0" + id="R_Transport_CO2" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1489,850.31855 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" + class="st32" + inkscape:transform-center-y="2.6134784" + inkscape:transform-center-x="-0.38596577" + inkscape:label="backward Transport_CO2 " + inkscape:connector-curvature="0" + id="B_Transport_CO2" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1440.8,877.21855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" + class="st32" + inkscape:label="backward SLC25A16 " + inkscape:connector-curvature="0" + id="B_SLC25A16" /><path + style="fill:none;stroke:#000000;stroke-width:1.79229999" + d="m 1492.5,875.11855 -51.4,0 0,0" + class="st43" + inkscape:label="SLC25A16 " + inkscape:connector-curvature="0" + id="R_SLC25A16" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1490.5,872.71855 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" + class="st32" + inkscape:transform-center-y="2.6134784" + inkscape:transform-center-x="-0.38596577" + inkscape:label="forward SLC25A16 " + inkscape:connector-curvature="0" + id="F_SLC25A16" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text362" + class="st15 st16" + x="1501.2006" + y="899.49829">NH</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text364" + class="st15 st40" + x="1521.8334" + y="902.69849">3</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text366" + class="st15 st16" + x="1402.0922" + y="899.6507">NH</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text368" + class="st15 st40" + x="1422.725" + y="902.85089">3</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1439.3,896.71855 c -6.9,-2.1 -6.9,-2.1 -6.9,-2.1 l 6.9,-2.3 -1.7,2.2 1.7,2.2 z" + class="st32" + inkscape:label="forward HIBCH " + inkscape:connector-curvature="0" + id="F_HIBCH" /><path + style="fill:none;stroke:#000000;stroke-width:1.86909997" + d="m 1494.1,894.91855 -55.9,0 0,0" + class="st44" + inkscape:label="HIBCH " + inkscape:connector-curvature="0" + id="R_HIBCH" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1490.8,892.61855 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" + class="st32" + inkscape:transform-center-y="2.6134784" + inkscape:transform-center-x="-0.38596577" + inkscape:label="backward HIBCH " + inkscape:connector-curvature="0" + id="B_HIBCH" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text373" + class="st15 st16" + x="183.5808" + y="877.27655">AKG</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text375" + class="st15 st16" + x="284.44901" + y="878.07635">AKG</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.82299995" + d="m 275.8,872.81855 -60.2,-0.3 m 44.6,0.3 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -26.7,14.1 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7" + class="st45" + inkscape:connector-curvature="0" + id="R_SLC25A10_3" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text378" + class="st15 st38" + x="225.0891" + y="851.62427">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.35560012" + d="m 233.9,861.71855 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m 40.1,13.1 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" + class="st46" + inkscape:connector-curvature="0" + id="F_SLC25A10_3" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text381" + class="st15 st16" + x="541.16345" + y="867.11346">OAA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text383" + class="st15 st16" + x="444.4646" + y="817.42017">AcCoA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text385" + class="st15 st16" + x="552.0061" + y="801.70825">Cit</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text387" + class="st15 st16" + x="584.02271" + y="750.14575">Isocit</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text389" + class="st15 st16" + x="720.78931" + y="750.92017">AKG</text> +<text + style="font-size:10px;font-family:Calibri" + id="text391" + class="st17 st18" + x="618.72882" + y="720.4563">NADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text393" + class="st17 st18" + x="647.54321" + y="718.54126">NADPH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text395" + class="st17 st18" + x="620.67413" + y="781.10181">NAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text397" + class="st17 st18" + x="649.48175" + y="783.26978">NADH</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text399" + class="st15 st16" + x="762.93884" + y="808.12225">SuCoA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text401" + class="st15 st16" + x="768.40649" + y="883.388">Succ</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text403" + class="st15 st16" + x="702.18781" + y="941.1272">Fum</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text405" + class="st15 st16" + x="578.7005" + y="921.75116">Mal</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.04839993" + d="m 566.7,779.01855 c -1.3,6.1 -1.3,6.1 -1.3,6.1 l 4.5,-4.4 -2.3,0.5 -0.9,-2.2 z" + class="st47" + inkscape:label="backward aconitase" + inkscape:connector-curvature="0" + id="B_ACO2_ACO1_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.12699997" + d="m 566.9,782.01855 c 4.6,-9.3 11.1,-17.4 19,-23.8" + class="st48" + inkscape:connector-curvature="0" + id="R_ACO2_ACO1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.04839993" + d="m 585.4,760.31855 c 3.7,-5 3.7,-5 3.7,-5 l -5.8,2.2 2.3,0.5 -0.2,2.3 z" + class="st47" + inkscape:label="forward aconitase" + inkscape:connector-curvature="0" + id="F_ACO2_ACO1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.04839993" + d="m 613.2,930.01855 c -5.9,-2.2 -5.9,-2.2 -5.9,-2.2 l 3.7,5 -0.1,-2.3 2.3,-0.5 z" + class="st47" + inkscape:label="forward fumarase" + inkscape:connector-curvature="0" + id="F_FH_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.53830004" + d="m 750,753.21855 c 11.4,9.5 20.7,21.6 27.4,35.6 m 7.1,-13.7 c -5.5,3.4 -13.1,1.9 -17.3,-3.3 -4.2,-5.2 -3.5,-12.4 1.5,-16.3" + class="st49" + inkscape:label="DLSTP1_DLD_OGDH_PDHX_DLST_DHTKD1_OGDHL" + inkscape:connector-curvature="0" + id="R_DLSTP1_DLD_OGDH_PDHX_DLST_DHTKD1_OGDHL" /><text + style="font-size:10px;font-family:Calibri" + id="text412" + class="st17 st18" + x="770.49744" + y="758.63306">NAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text414" + class="st17 st18" + x="788.89093" + y="758.63306">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text416" + class="st17 st18" + x="793.8714" + y="758.63306">CoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.4921" + d="m 804.5,854.61855 c -5.7,0.4 -11.1,-2.1 -14.1,-6.4 -3,-4.3 -3,-9.8 -0.1,-14.1 2.9,-4.3 8.3,-6.9 14,-6.5 m -18.4,38.9 c 3.7,-17.5 3.4,-35.7 -0.7,-53.3" + class="st50" + inkscape:connector-curvature="0" + id="R_KANK1_SUCLA2_SUCLG1_SUCLG2_1" /><text + style="font-size:10px;font-family:Calibri" + id="text419" + class="st17 st18" + x="812.39685" + y="828.55005">GDP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text421" + class="st17 st18" + x="830.02374" + y="828.55005">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text423" + class="st17 st18" + x="835.00421" + y="828.55005">Pi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text425" + class="st17 st18" + x="814.06671" + y="857.71606">GTP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text427" + class="st17 st18" + x="830.36554" + y="857.71606">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text429" + class="st17 st18" + x="835.34601" + y="857.71606">CoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.41170001" + d="m 762.8,933.01855 c -4.7,-2.1 -7.7,-6.5 -7.5,-11.2 0.2,-4.7 3.4,-8.9 8.2,-10.5 4.8,-1.7 10.3,-0.5 14,2.9 m -2.6,-22 c -9,15.5 -21.4,28.8 -36.4,39.2" + class="st51" + inkscape:connector-curvature="0" + id="R_SDHA_SDHB_SDHC_SDHD" /><text + style="font-size:10px;font-family:Calibri" + id="text432" + class="st17 st18" + x="784.63501" + y="920.19165">FAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text434" + class="st17 st18" + x="764.34894" + y="943.30975">FADH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text436" + class="st17 st26" + x="786.55115" + y="945.30975">2</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.37870002" + d="m 578.6,907.21855 c -8.4,-8.4 -15,-18.8 -19.3,-30.4 m -8,12 c 3.1,-2 7.4,-2.3 10.9,-0.8 3.6,1.6 5.8,4.7 5.8,8.2 0,3.4 -2.2,6.6 -5.8,8" + class="st52" + inkscape:connector-curvature="0" + id="R_MDH2" /><text + style="font-size:10px;font-family:Calibri" + id="text439" + class="st17 st18" + x="537.08234" + y="912.11646">NAD</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text441" + class="st15 st16" + x="451.4158" + y="732.70825">Pyr</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.24370003" + d="m 464.2,739.41855 0.2,56.6 m -0.5,-21.6 c 1.5,5.9 13.6,4.1 13.6,4.1 m -13.3,-14.1 c 1.5,5.9 13.4,4.1 13.4,4.1 m -13.1,1.8 c -1.6,-6 -12.9,-5.2 -12.9,-5.2 m 12.4,-12.6 c -1.5,-6 -12.4,-5.2 -12.4,-5.2 m 12.7,6.1 c 1.5,5.9 13.2,4.1 13.2,4.1" + class="st53" + inkscape:label="DLD_PDHX_PDHA1_DLAT_PDHA2_PDHB " + inkscape:connector-curvature="0" + id="R_DLD_PDHX_PDHA1_DLAT_PDHA2_PDHB" /><text + style="font-size:10px;font-family:Calibri" + id="text444" + class="st17 st18" + x="567.64972" + y="846.81366">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text446" + class="st17 st26" + x="573.88025" + y="848.81366">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text448" + class="st17 st18" + x="576.96814" + y="846.81366">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text450" + class="st17 st18" + x="569.51593" + y="825.74438">CoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text452" + class="st17 st18" + x="695.72681" + y="780.76196">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text454" + class="st17 st26" + x="707.5921" + y="782.76196">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text456" + class="st17 st18" + x="696.48865" + y="719.4046">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text458" + class="st17 st26" + x="708.35382" + y="721.4046">2</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.04839993" + d="m 664.2,952.91855 c 5.8,2.2 5.8,2.2 5.8,2.2 l -3.7,-5 0.1,2.3 -2.2,0.5 z m 27.9,-11.2 c 4.9,-3.8 4.9,-3.8 4.9,-3.8 l -6.2,0.6 2,1.1 -0.7,2.1 z" + class="st47" + inkscape:connector-curvature="0" + id="B_FH_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.84920001" + d="m 666.6,952.31855 -16.4,-9.8 m 41.7,-2.8 c -33.5,7.3 -52.1,2.6 -79.1,-8.8" + class="st54" + inkscape:connector-curvature="0" + id="R_FH_1" /><text + style="font-size:10px;font-family:Calibri" + id="text462" + class="st17 st18" + x="672.46021" + y="961.96796">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text464" + class="st17 st26" + x="678.69073" + y="963.96796">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text466" + class="st17 st18" + x="681.7796" + y="961.96796">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.81599998" + d="m 561.8,902.51855 c -4,4 -4,4 -4,4 l 5.5,-0.9 -1.9,-1 0.4,-2.1 z m 13.6,3.9 c 6,1.7 6,1.7 6,1.7 l -4.1,-4.7 0.3,2.3 -2.2,0.7 z" + class="st55" + inkscape:connector-curvature="0" + id="B_MDH2" /><path + style="fill:none;stroke:#000000;stroke-width:1.81599998" + d="m 739.7,928.21855 c -4.1,4.7 -4.1,4.7 -4.1,4.7 l 6,-1.7 -2.2,-0.7 0.3,-2.3 z m 21.4,5.7 c 5.3,1.4 5.3,1.4 5.3,1.4 l -3.6,-4.5 0.3,2.3 -2,0.8 z" + class="st55" + inkscape:connector-curvature="0" + id="F_SDHA_SDHB_SDHC_SDHD" /><path + style="fill:none;stroke:#000000;stroke-width:1.81599998" + d="m 774.9,896.21855 c 1.3,-6.1 1.3,-6.1 1.3,-6.1 l -4.4,4.4 2.3,-0.5 0.8,2.2 z m 1.2,19.4 c 6.1,1.1 6.1,1.1 6.1,1.1 l -4.5,-4.3 0.5,2.2 -2.1,1 z" + class="st55" + inkscape:connector-curvature="0" + id="B_SDHA_SDHB_SDHC_SDHD" /><path + style="fill:none;stroke:#000000;stroke-width:1.81599998" + d="m 785.2,863.01855 c 0.1,6.2 0.1,6.2 0.1,6.2 l 3.3,-5.3 -2.1,1 -1.3,-1.9 z m 18.8,-7 c 6.1,-1.5 6.1,-1.5 6.1,-1.5 l -5.9,-2 1.4,1.8 -1.6,1.7 z" + class="st55" + inkscape:connector-curvature="0" + id="F_KANK1_SUCLA2_SUCLG1_SUCLG2_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.81599998" + d="m 788.1,817.61855 c -3.6,-5.1 -3.6,-5.1 -3.6,-5.1 l 0.2,6.2 1.2,-2 2.2,0.9 z m 14.8,11.6 c 6,-1.6 6,-1.6 6,-1.6 l -5.9,-1.9 1.5,1.8 -1.6,1.7 z" + class="st55" + inkscape:connector-curvature="0" + id="B_KANK1_SUCLA2_SUCLG1_SUCLG2_1" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text473" + class="st15 st16" + x="177.26639" + y="802.27655">Fum</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text475" + class="st15 st16" + x="283.87378" + y="800.91235">Fum</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.82299995" + d="m 275.8,797.81855 -60.2,-0.3 m 44.6,0.2 c 5.9,-1.6 4.4,-15.3 4.4,-15.3 m -31.3,15.6 c -6.4,-4.5 -7.8,-15.5 -5,-15.5" + class="st45" + inkscape:connector-curvature="0" + id="R_SLC25A10_4" /><path + style="fill:none;stroke:#000000;stroke-width:2.0158999" + d="m 229.9,783.11855 c -2.1,-4.9 -2.1,-4.9 -2.1,-4.9 l -2,5 2.1,-1.3 2,1.2 z m 44.1,16.7 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" + class="st56" + inkscape:label=" B SLC25A10_4" + inkscape:connector-curvature="0" + id="B_SLC25A10_4" /><path + style="fill:none;stroke:#000000;stroke-width:2.00889993" + d="m 267,783.11855 c -1.6,-5.3 -1.6,-5.3 -1.6,-5.3 l -2.3,5.1 2,-1.2 1.9,1.4 z m -50.7,12.4 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" + class="st57" + inkscape:label="F SLC25A10_4" + inkscape:connector-curvature="0" + id="F_SLC25A10_4" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text480" + class="st15 st38" + x="260.33328" + y="777.0979">Pi</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text482" + class="st15 st38" + x="222.5813" + y="777.03638">Pi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text484" + class="st17 st18" + x="482.52859" + y="702.16626">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text486" + class="st17 st18" + x="444.9617" + y="668.1311">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text488" + class="st15 st16" + x="465.6225" + y="1131.1801">NAD</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text490" + class="st15 st16" + x="499.44772" + y="1131.5101">QH</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text492" + class="st15 st40" + x="520.51807" + y="1134.7103">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text494" + class="st15 st16" + x="396.8374" + y="1133.059">5 H</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.26660001" + d="m 380.1998,1138.2711 0,17.7 133.5,0 0,-17.7 m -104.6,-1.6 0,18.7 m 26.7,-18.1 0,18.2 m 49,0 0,-17 m -13,17 0,28.6" + class="st58" + inkscape:connector-curvature="0" + id="R_Complex1ROS" + inkscape:label="#R_Complex1ROS" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text505" + class="st15 st16" + x="580.42444" + y="1130.2744">2 Cytc-ox</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text507" + class="st15 st16" + x="738.55164" + y="1130.0198">2 Cytc-red</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text509" + class="st15 st16" + x="834.18854" + y="1130.3486">Q</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text511" + class="st15 st16" + x="667.68347" + y="1131.8838">2H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text513" + class="st15 st16" + x="702.59131" + y="1130.5463">QH</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text515" + class="st15 st40" + x="723.66162" + y="1135.3677">2</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.29487193" + d="m 643.71124,1137.3649 0,18.3 195.54681,0 0,-18.3 m -159.78839,-0.3 0,18.2 m 41.6057,-17.5 0,17.4 m 65.782,0.1 0,-15.3 m -27.54973,15.6 0,24.5" + class="st60" + inkscape:connector-curvature="0" + id="R_Complex3" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text518" + class="st15 st16" + x="746.68384" + y="1199.0907">4 H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text520" + class="st15 st16" + x="888.39905" + y="1132.1252">4 Cytc-red</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text522" + class="st15 st16" + x="1039.7281" + y="1131.0266">4 Cytc-ox</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text524" + class="st15 st16" + x="1123.9191" + y="1132.1672">2H</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text526" + class="st15 st40" + x="1145.7395" + y="1135.3684">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text528" + class="st15 st16" + x="1150.6809" + y="1132.1672">O</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text530" + class="st15 st16" + x="981.8186" + y="1132.9836">8H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text532" + class="st15 st16" + x="1011.5463" + y="1132.6321">O</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text534" + class="st15 st40" + x="1022.3666" + y="1135.8323">2</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.18280005" + d="m 951.7,1138.8186 0,16.2 192.2,0 0,-16.2 m -152.2,-0.5 0,16.2 m 26.6,-15.7 0,15.8 m 53.3,-0.1 0,-13.8 m -23.8,13.8 0,25.4" + class="st61" + inkscape:connector-curvature="0" + id="R_Complex4" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text537" + class="st15 st16" + x="1035.0892" + y="1196.552">4 H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text539" + class="st15 st16" + x="890.96515" + y="866.2962">CO</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text541" + class="st15 st40" + x="910.13702" + y="869.4964">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text543" + class="st15 st16" + x="962.79913" + y="866.07635">HCO</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text545" + class="st15 st40" + x="992.0647" + y="869.27655">3</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text547" + class="st15 st40" + x="997.0061" + y="857.27655">-</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.06990004" + d="m 929.8,861.11855 c -6.3,1.9 -5.8,15.6 -5.8,15.6 m 12.8,-15.5 c 6.4,1.4 4.8,12.8 4.8,12.8 m 11,-13 -36,-0.3" + class="st62" + inkscape:connector-curvature="0" + id="R_CA5B_CA5A" /><text + style="font-size:10px;font-family:Calibri" + id="text550" + class="st17 st18" + x="938.54132" + y="886.07739">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text552" + class="st17 st18" + x="913.19171" + y="885.12616">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text554" + class="st17 st26" + x="919.42224" + y="887.12616">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text556" + class="st17 st18" + x="922.51105" + y="885.12616">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 1170.1,1230.7186 2.1,-7.3 2.3,7.3 -2.2,-1.8 -2.2,1.8 z" + class="st14" + inkscape:label="Glucose_DM_COOP b" + inkscape:connector-curvature="0" + id="B_Glucose_DM_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 1172.1,1229.4186 0.7,48.1" + class="st14" + inkscape:label="Glucose_DM_COOP" + inkscape:connector-curvature="0" + id="R_Glucose_DM_COOP" /><a + transform="translate(1273.3622,1205.6018)" + xlink:href="http://www.genome.jp/dbget-bin/www_bget?cpd:C00031" + id="a14384-0"><text + style="font-size:16px;font-family:Calibri-Bold" + id="text561" + class="st15 st16" + transform="translate(-116.0982,12.7041)">Glc</text> +</a><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 501.1,1274.6186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" + class="st63" + inkscape:label="Ex_SC_H2O f" + inkscape:connector-curvature="0" + id="F_Ex_SC_H2O" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 503.2,1227.4186 0,47.6" + class="st63" + inkscape:label="Ex_SC_H2O" + inkscape:connector-curvature="0" + id="R_Ex_SC_H2O" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text565" + class="st15 st16" + x="488.92899" + y="1219.1184">H</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text567" + class="st15 st40" + x="499.02267" + y="1222.3176">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text569" + class="st15 st16" + x="503.96512" + y="1219.1184">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.67510009" + d="m 561.7,1232.4186 -2.2,-7.1 -2.2,7.1 2.2,-1.8 2.2,1.8 z" + class="st64" + inkscape:label="Ex_O2 b" + inkscape:connector-curvature="0" + id="B_Ex_O2" /><path + style="fill:none;stroke:#000000;stroke-width:2.67510009" + d="m 559.6,1278.6186 0,-46.6" + class="st64" + inkscape:label="Ex_O2" + inkscape:connector-curvature="0" + id="R_Ex_O2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text573" + class="st15 st16" + x="553.19659" + y="1218.1301">O</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text575" + class="st15 st40" + x="564.01691" + y="1221.3303">2</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 1236.1431,1273.3107 -2.2,7.3 -2.2,-7.3 2.2,1.8 2.2,-1.8 z" + class="st14" + inkscape:label="Glutamine_DM_COOP f" + inkscape:connector-curvature="0" + id="F_Glutamine_DM_COOP" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text579" + class="st15 st16" + x="1219.5931" + y="1218.3059">Gln</text> +<path + style="fill:none;stroke:#000000;stroke-width:3.16359997" + d="m 643.8,1274.6186 2.2,6.9 2.2,-6.9 -2.2,1.7 -2.2,-1.7 z" + class="st65" + inkscape:label="forward Ex_NH3 " + inkscape:connector-curvature="0" + id="F_Ex_NH3" /><path + style="fill:none;stroke:#000000;stroke-width:3.36989999" + d="m 645.9,1223.3186 0,51.7" + class="st66" + inkscape:label="Ex_NH3 " + inkscape:connector-curvature="0" + id="R_Ex_NH3" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text583" + class="st15 st16" + x="635.18091" + y="1219.1711">NH</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text585" + class="st15 st40" + x="655.81384" + y="1222.3713">3</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 841.2,1232.3186 2.2,-7.3 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" + class="st14" + inkscape:label="DM_Folate f" + inkscape:connector-curvature="0" + id="F_DM_Folate" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 843.5,1276.7186 -0.3,-48.1" + class="st14" + inkscape:label="DM_Folate" + inkscape:connector-curvature="0" + id="R_DM_Folate" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text589" + class="st15 st16" + x="821.54034" + y="1218.8098">Folate</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.31469989" + d="m 689.2,1223.4186 0,56.6" + class="st67" + inkscape:label="DM_Urea" + inkscape:connector-curvature="0" + id="R_DM_Urea" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text592" + class="st15 st16" + x="672.34991" + y="1218.9426">Urea</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.22029996" + d="m 890.5,1223.6186 0.3,50.4" + class="st68" + inkscape:label="DM_putrescine" + inkscape:connector-curvature="0" + id="R_DM_putrescine" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text595" + class="st15 st16" + x="873.35284" + y="1219.4836">Putr</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text597" + class="st15 st16" + x="1115.0238" + y="1218.8967">Lact</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 1141.3465,1230.8815 -2.2,-7.7 -2.2,7.7 2.2,-1.9 2.2,1.9 z" + class="st69" + inkscape:label="LactateL_DM_COOP b" + inkscape:connector-curvature="0" + id="B_LactateL_DM_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 501.1,1232.3186 2.1,-7.3 2.3,7.3 -2.2,-1.8 -2.2,1.8 z" + class="st14" + inkscape:label="Ex_SC_H2O b" + inkscape:connector-curvature="0" + id="B_Ex_SC_H2O" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 532.3,1274.6186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" + class="st63" + inkscape:label="forward Ex_SC_H " + inkscape:connector-curvature="0" + id="F_Ex_SC_H" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 534.4,1227.4186 0,47.6" + class="st63" + inkscape:label="Ex_SC_Hs" + inkscape:connector-curvature="0" + id="R_Ex_SC_Hs" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text604" + class="st15 st16" + x="529.56775" + y="1219.1184">H</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 532.3,1232.3186 2.1,-7.3 2.3,7.3 -2.2,-1.8 -2.2,1.8 z" + class="st14" + inkscape:label="backward Ex_SC_H " + inkscape:connector-curvature="0" + id="B_Ex_SC_H" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 687.5,1275.3186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" + class="st63" + inkscape:label="DM_Urea f" + inkscape:connector-curvature="0" + id="F_DM_Urea" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 888.7,1273.2186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" + class="st63" + inkscape:label="DM_putrescine f" + inkscape:connector-curvature="0" + id="F_DM_putrescine" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text609" + class="st15 st16" + x="1258.4867" + y="1218.8098">Glu</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 1267.4,1273.3186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" + class="st69" + inkscape:label="Glutamate_DM_COOP f" + inkscape:connector-curvature="0" + id="F_Glutamate_DM_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 1270,1225.4186 0,50.5" + class="st69" + inkscape:label="Glutamate_DM_COOP" + inkscape:connector-curvature="0" + id="R_Glutamate_DM_COOP" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text613" + class="st15 st16" + x="1294.558" + y="1219.0598">Arg</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 1305.8,1231.5186 2.2,1.8 -2.2,-7.2 -2.2,7.2 2.2,-1.8 z" + class="st63" + inkscape:label="Arginine_DM_COOP f" + inkscape:connector-curvature="0" + id="F_Arginine_DM_COOP" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text616" + class="st15 st16" + x="577.40161" + y="1218.1838">CO</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text618" + class="st15 st40" + x="598.57355" + y="1221.384">2</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 590,1229.9186 0,47.6" + class="st63" + inkscape:label="DM_CO2c" + inkscape:connector-curvature="0" + id="R_DM_CO2c" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text622" + class="st15 st16" + x="615.26984" + y="1219.7141">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 620.5,1233.9186 0,47.6" + class="st63" + inkscape:label="Ex_SC_Pi " + inkscape:connector-curvature="0" + id="R_Ex_SC_Pi" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 620.6,1232.5186 2.2,1.8 -2.2,-7.2 -2.2,7.2 2.2,-1.8 z" + class="st63" + inkscape:label="Ex_SC_Pi b" + inkscape:connector-curvature="0" + id="B_Ex_SC_Pi" /><path + style="fill:none;stroke:#000000;stroke-width:1.96669996" + d="m 587.5,1271.4186 1.9,6.8 1.9,-6.8 -1.9,1.7 -1.9,-1.7 z" + class="st70" + inkscape:label="FORWARD DM_CO2c" + inkscape:connector-curvature="0" + id="F_DM_CO2c" /><path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 618.6,1275.0186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" + class="st69" + inkscape:label="Ex_SC_Pi f" + inkscape:connector-curvature="0" + id="F_Ex_SC_Pi" /><path + style="fill:none;stroke:#000000;stroke-width:2.13409996" + d="m 927.4,1281.5186 -0.8,-56.3" + class="st71" + inkscape:label="DM_guanidinoacetatec" + inkscape:connector-curvature="0" + id="R_DM_guanidinoacetatec" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 927.19047,1278.0186 -2.3,-1.7 2.4,7.2 2,-7.3 -2.1,1.8 z" + class="st63" + inkscape:label="DM_guanidinoacetatec f" + inkscape:connector-curvature="0" + id="F_DM_guanidinoacetatec" /><text + style="font-size:15.99923611px;font-family:Calibri-Bold" + id="text630" + class="st15 st16" + transform="matrix(0.99984771,-0.01745156,0.01745156,0.99984771,0,0)" + x="896.45245" + y="1235.1273">GA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text632" + class="st17 st18" + x="813.1839" + y="294.34796">Asp</text> +<text + style="font-size:10px;font-family:Calibri" + id="text634" + class="st17 st18" + x="847.99152" + y="294.67303">2 ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text636" + class="st17 st18" + x="838.64294" + y="261.41425">QH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text638" + class="st17 st26" + x="851.60181" + y="263.41425">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text640" + class="st17 st18" + x="859.31573" + y="261.81076">2 ADP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text642" + class="st15 st16" + x="950.24341" + y="283.13986">UMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text644" + class="st17 st18" + x="792.67413" + y="295.08524">Gln</text> +<text + style="font-size:10px;font-family:Calibri" + id="text646" + class="st17 st18" + x="800.29321" + y="261.82446">Glu</text> +<text + style="font-size:10px;font-family:Calibri" + id="text648" + class="st17 st18" + x="886.02863" + y="294.47684">HCO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text650" + class="st17 st26" + x="904.12433" + y="296.47684">3</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text652" + class="st17 st26" + x="907.2132" + y="288.97684">-</text> +<text + style="font-size:10px;font-family:Calibri" + id="text654" + class="st17 st18" + x="835.15265" + y="294.92795">Q</text> +<text + style="font-size:10px;font-family:Calibri" + id="text656" + class="st17 st18" + x="875.8938" + y="294.94363">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text658" + class="st17 st18" + x="906.9231" + y="262.21405">PPi</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text660" + class="st15 st16" + x="953.64874" + y="337.59396">UDP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text662" + class="st17 st18" + x="995.4729" + y="301.37915">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text664" + class="st17 st18" + x="985.13312" + y="312.31955">ADP</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.5819" + d="m 937.8,332.81855 c -4.7,-0.3 -6.5,-11.7 -6.5,-11.7 m 21.4,11.5 -31.2,0.2" + class="st72" + inkscape:label="RRM2B_TXN_RRM1_RRM2_1" + inkscape:connector-curvature="0" + id="R_RRM2B_TXN_RRM1_RRM2_1" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text667" + class="st15 st16" + x="872.57452" + y="337.33325">dUDP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text669" + class="st17 st18" + x="920.89093" + y="314.44846">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text671" + class="st17 st26" + x="927.1214" + y="316.44846">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text673" + class="st17 st18" + x="930.21021" + y="314.44846">O</text> +<text + style="font-size:16.00037575px;font-family:Calibri-Bold" + id="text675" + class="st15 st16" + transform="matrix(0.99997657,-0.0068447,0.0068447,0.99997657,0,0)" + x="779.65546" + y="343.09702">dUMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text677" + class="st17 st18" + transform="matrix(0.99990048,0.01410788,-0.01410788,0.99990048,0,0)" + x="852.72308" + y="304.24103">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text679" + class="st17 st18" + transform="matrix(0.9998951,-0.01448404,0.01448404,0.9998951,0,0)" + x="827.13593" + y="328.46188">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text681" + class="st17 st18" + x="923.82745" + y="262.21405">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text683" + class="st17 st26" + x="935.69275" + y="264.21405">2</text> +<text + style="font-size:16.0006218px;font-family:Calibri-Bold" + id="text685" + class="st15 st16" + transform="matrix(0.99976114,-0.02185571,0.02185571,0.99976114,0,0)" + x="673.61633" + y="353.25659">dTMP</text> +<text + style="font-size:10.00026512px;font-family:Calibri" + id="text687" + class="st17 st18" + transform="matrix(0.99997352,-0.00727731,0.00727731,0.99997352,0,0)" + x="748.1861" + y="319.31909">meTHF</text> +<text + style="font-size:10.00010777px;font-family:Calibri" + id="text689" + class="st17 st18" + transform="matrix(0.99998921,0.00464547,-0.00464547,0.99998921,0,0)" + x="731.41992" + y="310.3287">DHF</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text691" + class="st15 st16" + x="1025.2386" + y="337.24924">UTP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text693" + class="st15 st16" + x="1113.8793" + y="337.43964">CTP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text695" + class="st17 st18" + x="1079.4359" + y="317.43384">ADP+Pi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text697" + class="st17 st18" + x="1039.0609" + y="317.67896">ATP+NH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text699" + class="st17 st26" + x="1071.7709" + y="319.67896">3</text> +<text + style="font-size:10px;font-family:Calibri" + id="text701" + class="st17 st18" + x="1163.5892" + y="316.63016">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text703" + class="st17 st18" + x="1144.7562" + y="317.36545">ADP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text705" + class="st15 st16" + x="1185.2777" + y="337.33524">CDP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1157.5,324.71855 c -1.6,-6.1 -1.6,-6.1 -1.6,-6.1 l -1.3,6.2 1.4,-1.6 1.5,1.5 z m -7,5.6 c -7.4,1.9 -7.4,1.9 -7.4,1.9 l 7.2,2.4 -1.8,-2.2 2,-2.1 z" + class="st73" + inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" + inkscape:connector-curvature="0" + id="B_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1174.1,335.71855 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z m -3.6,-10.9 c -1.1,-5.1 -1.1,-5.1 -1.1,-5.1 l -1.7,5 1.5,-1.2 1.3,1.3 z" + class="st22" + inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" + inkscape:connector-curvature="0" + id="F_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text709" + class="st15 st16" + x="1258.7123" + y="337.35764">CMP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.43479991" + d="m 1198.8,339.01855 -0.1,22.4 m -0.1,-17.5 c -0.2,5.3 -9.5,7.3 -9.5,7.3" + class="st74" + inkscape:connector-curvature="0" + id="R_RRM2B_TXN_RRM1_RRM2_2" /><text + style="font-size:10px;font-family:Calibri" + id="text712" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="1168.255" + y="353.44818">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text714" + class="st17 st26" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="1174.4854" + y="355.44815">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text716" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="1177.5743" + y="353.44812">O</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text718" + class="st15 st16" + x="1175.5306" + y="382.04416">dCDP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text720" + class="st15 st16" + x="360.74741" + y="449.50314">3PPyr</text> +<text + style="font-size:10px;font-family:Calibri" + id="text722" + class="st17 st18" + x="410.62479" + y="426.49734">NADH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text724" + class="st17 st18" + x="435.24878" + y="426.49734">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text726" + class="st17 st18" + x="440.22931" + y="426.49734">H</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.33130002" + d="m 446.2,443.81855 -34.2,0.2 m 20.4,0.1 c -4.3,-0.3 -6,-12.3 -6,-12.3 m 3.8,12.1 c 6.1,1.5 5.6,12.5 5.6,12.5" + class="st75" + inkscape:label="PHGDH_UBAC2 " + inkscape:connector-curvature="0" + id="R_PHGDH_UBAC2" /><text + style="font-size:10px;font-family:Calibri" + id="text729" + class="st17 st18" + x="427.62769" + y="465.14575">NAD</text> +<text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text731" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="356.75916" + y="399.59976">3PSer</text> +<text + style="font-size:10px;font-family:Calibri" + id="text733" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="345.07333" + y="429.83682">Glu</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text735" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="333.53885" + y="420.90979">AKG</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.0948" + d="m 377,437.71855 -0.2,-34.2 m -15.7,11.7 c 9.7,-2.9 16,3.2 16,3.2 m -0.2,3.4 c -1.4,5.3 -16.7,5.1 -16.7,5.1" + class="st76" + inkscape:connector-curvature="0" + id="R_PSAT1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 379.1,403.81855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -14,12.2 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" + class="st73" + inkscape:connector-curvature="0" + id="F_PSAT1" /><path + style="fill:none;stroke:#000000;stroke-width:2.23519993" + d="m 379.2,351.31855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z" + class="st77" + inkscape:label="VPS29_PSPH_PSPHP1 forward" + inkscape:connector-curvature="0" + id="F_VPS29_PSPH_PSPHP1" /><text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text740" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="359.90805" + y="346.62714">Ser</text> +<text + style="font-size:10px;font-family:Calibri" + id="text742" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="393.64661" + y="374.83282">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text744" + class="st17 st26" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="399.87701" + y="376.83292">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text746" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="402.96588" + y="374.83289">O</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text748" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="395.1853" + y="368.10416">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.0948" + d="m 377,367.81855 c 0.6,2.3 3,3.4 5.1,4.1 2.9,0.8 6,1.1 9,1.1 m 1.7,-11.8 c -5.4,-1.7 -11.7,-0.5 -16,3.2 m 0.3,19.3 c -0.1,-11.4 -0.1,-22.8 -0.2,-34.2" + class="st76" + inkscape:label="VPS29_PSPH_PSPHP1 " + inkscape:connector-curvature="0" + id="R_VPS29_PSPH_PSPHP1" /><text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text751" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="360.82996" + y="259.71588">Gly</text> +<text + style="font-size:10px;font-family:Calibri" + id="text753" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="399.81461" + y="284.13171">THF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 390.2,284.61855 c 7,-1.3 7,-1.3 7,-1.3 l -6.8,-1.9 1.7,1.7 -1.9,1.5 z m -15.6,36.9 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z" + class="st73" + inkscape:connector-curvature="0" + id="B_SHMT1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 425.5,435.31855 c -0.5,-7.1 -0.5,-7.1 -0.5,-7.1 l 3.5,6.2 -2,-1.2 -1,2.1 z m -11.7,11 c -6.3,-2.2 -6.3,-2.2 -6.3,-2.2 l 6.5,-1.7 -1.7,1.9 1.5,2 z" + class="st73" + inkscape:label="PHGDH_UBAC2 forward" + inkscape:connector-curvature="0" + id="F_PHGDH_UBAC2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text757" + class="st15 st16" + x="422.2869" + y="341.40353">Pyr</text> +<text + style="font-size:10px;font-family:Calibri" + id="text759" + class="st17 st18" + x="396.70538" + y="319.50906">NH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text761" + class="st17 st26" + x="409.3909" + y="321.50906">3</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.38170004" + d="m 398.5,338.71855 c 3.7,-0.3 5.1,-10.5 5.1,-10.5 m -16.8,10.6 26.2,-0.2" + class="st78" + inkscape:connector-curvature="0" + id="R_SDS_SDSL_SRR" /><text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text764" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="141.05353" + y="304.02942">DHF</text> +<text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text766" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="136.36797" + y="245.96878">Folate</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 158.1,279.71855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m 14.1,-2.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" + class="st73" + inkscape:label="DHFRL1_DHFR_2 forward" + inkscape:connector-curvature="0" + id="F_DHFRL1_DHFR_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 159.9,281.31855 -0.2,-34.2 m 15.9,8.5 c -9.7,-2.9 -16,3.2 -16,3.2 m 0.3,11.4 c 1.4,5.3 17.3,5.1 17.3,5.1" + class="st79" + inkscape:label="DHFRL1_DHFR_2 " + inkscape:connector-curvature="0" + id="R_DHFRL1_DHFR_2" /><text + style="font-size:10px;font-family:Calibri" + id="text770" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="184.45857" + y="280.61414">NADP</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text772" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="179.325" + y="260.32965">NADPH</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text774" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="179.32498" + y="272.82965">+H</text> +<text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text776" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="141.77278" + y="368.62994">THF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 157.7,343.41855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m 14.1,-2.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" + class="st73" + inkscape:label="DHFRL1_DHFR_4 forward" + inkscape:connector-curvature="0" + id="F_DHFRL1_DHFR_4" /><path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 159.5,345.01855 -0.2,-34.2 m 15.9,8.5 c -9.7,-2.9 -16,3.2 -16,3.2 m 0.2,11.4 c 1.4,5.3 17.3,5.1 17.3,5.1" + class="st79" + inkscape:label="DHFRL1_DHFR_4 " + inkscape:connector-curvature="0" + id="R_DHFRL1_DHFR_4" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 161.5,312.61855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m 9.7,7.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" + class="st73" + inkscape:label="DHFRL1_DHFR_4 " + inkscape:connector-curvature="0" + id="B_DHFRL1_DHFR_4" /><text + style="font-size:10px;font-family:Calibri" + id="text781" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="181.55092" + y="341.92856">NADP</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text783" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="177.77963" + y="322.29248">NADPH</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text785" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="177.77962" + y="334.79254">+H</text> +<text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text787" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="122.12817" + y="433.13483">10-formyl</text> +<text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text789" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="141.62041" + y="453.13483">THF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 157.3,407.81855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m 14.1,-2.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" + class="st73" + inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297 foward" + inkscape:connector-curvature="0" + id="F_MTHFD1_AL445665_1_AQP7P4_LOC286297" /><path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 159,409.41855 -0.2,-34.2 m 15.9,8.5 c -9.7,-2.9 -16,3.2 -16,3.2 m 0.3,11.4 c 1.4,5.3 17.3,5.1 17.3,5.1" + class="st79" + inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297 " + inkscape:connector-curvature="0" + id="R_MTHFD1_AL445665_1_AQP7P4_LOC286297" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 161.1,377.01855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m 9.7,7.5 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" + class="st73" + inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297 backward" + inkscape:connector-curvature="0" + id="B_MTHFD1_AL445665_1_AQP7P4_LOC286297" /><text + style="font-size:10px;font-family:Calibri" + id="text794" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="181.41222" + y="406.33478">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text796" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="198.51668" + y="406.33478">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text798" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="203.49713" + y="406.33481">Pi</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text800" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="176.62868" + y="387.771">for+ATP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 221.4,395.51855 c 1.4,5.3 17.3,5.1 17.3,5.1 m -1.6,-19.7 c -9.7,-2.9 -16,3.2 -16,3.2 m -14.9,44.3 14.4,0 0,-68 -39.6,0" + class="st79" + inkscape:label="MTHFD1_3 " + inkscape:connector-curvature="0" + id="R_MTHFD1_3" /><text + style="font-size:10px;font-family:Calibri" + id="text803" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="250.68755" + y="398.89441">NADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text805" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="274.24716" + y="398.89441">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text807" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="250.68761" + y="411.39444">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text809" + class="st17 st26" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="256.91809" + y="413.39441">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text811" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="260.00687" + y="411.39438">O</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text813" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="242.4368" + y="378.47998">NADPH+</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text815" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="242.43677" + y="390.98007">H+CO</text> +<text + style="font-size:6.09346962px;font-family:Calibri" + id="text817" + class="st17 st26" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="265.513" + y="392.98007">2</text> +<text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text819" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="261.84116" + y="348.57727">mTHF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09509993" + d="m 204.8,436.41855 79.8,0 0,-84 m 16,24.7 c -9.7,-2.9 -16,3.2 -16,3.2 m 0.3,11.4 c 1.4,5.3 17.3,5.1 17.3,5.1" + class="st80" + inkscape:connector-curvature="0" + id="R_MTHFD1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 296,378.11855 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z m -9.3,-24.4 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z" + class="st73" + inkscape:label="MTHFD1_1 forward" + inkscape:connector-curvature="0" + id="F_MTHFD1_1" /><text + style="font-size:10px;font-family:Calibri" + id="text823" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="309.67828" + y="399.18741">H</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 299.8,398.21855 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z m -93.6,36.5 c -6.3,2.3 -6.3,2.3 -6.3,2.3 l 6.5,1.7 -1.7,-1.9 1.5,-2.1 z" + class="st73" + inkscape:connector-curvature="0" + id="B_MTHFD1_1" /><text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text826" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="254.19125" + y="282.20911">meTHF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 277.6,301.91855 c -1.6,-5.3 -17.5,-4.5 -17.5,-4.5 m 2.3,19.7 c 9.8,2.5 15.9,-3.8 15.9,-3.8 m 0.3,11.1 -0.2,-34.2" + class="st79" + inkscape:label="MTHFD2_1 " + inkscape:connector-curvature="0" + id="R_MTHFD2_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 280.6,292.01855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -15.6,3.3 c -7,1.6 -7,1.6 -7,1.6 l 6.9,1.6 -1.7,-1.6 1.8,-1.6 z" + class="st73" + inkscape:label="MTHFD2_1 forward" + inkscape:connector-curvature="0" + id="F_MTHFD2_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 266.3,316.11855 c -7,1.6 -7,1.6 -7,1.6 l 6.9,1.6 -1.7,-1.6 1.8,-1.6 z m 10.5,6.6 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z" + class="st73" + inkscape:label="MTHFD2_1 backward" + inkscape:connector-curvature="0" + id="B_MTHFD2_1" /><rect + style="fill:none;stroke:#231f20;stroke-width:7;stroke-linejoin:round;stroke-miterlimit:2" + height="487.10001" + width="1218.2" + class="st81" + y="682.21857" + x="248.5" + id="rect3188" /><text + style="font-size:10px;font-family:Calibri" + id="text832" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="229.13246" + y="320.30942">NADPH</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text834" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="229.66826" + y="302.43216">NADP</text> +<text + style="font-size:16.0003109px;font-family:Calibri-Bold" + id="text836" + class="st15 st16" + transform="matrix(0.9999806,0.00622953,-0.00622953,0.9999806,0,0)" + x="748.04932" + y="1068.5068">DHF</text> +<text + style="font-size:15.99927998px;font-family:Calibri-Bold" + id="text838" + class="st15 st16" + transform="matrix(0.99984501,-0.01760548,0.01760548,0.99984501,0,0)" + x="629.1507" + y="1083.5598">Folate</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 730.9,1070.9186 c 7.4,-2 7.4,-2 7.4,-2 l -7.2,-2.3 1.8,2.2 -2,2.1 z m -2.4,-14.1 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" + class="st73" + inkscape:label="DHFRL1_DHFR_5 forward" + inkscape:connector-curvature="0" + id="F_DHFRL1_DHFR_5" /><path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 732.5,1069.2186 -34.2,0 m 8.6,-15.9 c -2.9,9.6 3.1,16 3.1,16 m 11.4,-0.2 c 5.3,-1.4 5.2,-17.3 5.2,-17.3" + class="st79" + inkscape:label="DHFRL1_DHFR_5 " + inkscape:connector-curvature="0" + id="R_DHFRL1_DHFR_5" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 700.1,1066.9186 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z m 7.6,-9.7 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" + class="st73" + inkscape:label="DHFRL1_DHFR_5 backward" + inkscape:connector-curvature="0" + id="B_DHFRL1_DHFR_5" /><text + style="font-size:9.99962521px;font-family:Calibri" + id="text843" + class="st17 st18" + transform="matrix(0.9997375,0.02291141,-0.02291141,0.9997375,0,0)" + x="744.8653" + y="1031.0618">NADP</text> +<text + style="font-size:9.9998436px;font-family:Calibri" + id="text845" + class="st17 st18" + transform="matrix(0.99991568,-0.012986,0.012986,0.99991568,0,0)" + x="662.83777" + y="1056.4205">NADPH+H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text847" + class="st15 st16" + transform="matrix(0.99999758,-0.00219903,0.00219903,0.99999758,0,0)" + x="825.8905" + y="1075.1088">THF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 812.4,1070.3186 c 7.3,-2 7.3,-2 7.3,-2 l -7.2,-2.3 1.8,2.2 -1.9,2.1 z m -2.4,-14.1 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" + class="st73" + inkscape:label="DHFRL1_DHFR_6 forward" + inkscape:connector-curvature="0" + id="F_DHFRL1_DHFR_6" /><path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 814,1068.5186 -34.2,0 m 8.6,-15.8 c -2.9,9.6 3.1,16 3.1,16 m 11.4,-0.2 c 5.3,-1.4 5.2,-17.3 5.2,-17.3" + class="st79" + inkscape:label="DHFRL1_DHFR_6 " + inkscape:connector-curvature="0" + id="R_DHFRL1_DHFR_6" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 781.6,1066.3186 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z m 7.5,-9.7 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" + class="st73" + inkscape:label="DHFRL1_DHFR_6 backward" + inkscape:connector-curvature="0" + id="B_DHFRL1_DHFR_6" /><text + style="font-size:10.00011921px;font-family:Calibri" + id="text852" + class="st17 st18" + transform="matrix(0.99998813,0.00487302,-0.00487302,0.99998813,0,0)" + x="809.07843" + y="1042.3011">NADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text854" + class="st17 st18" + transform="matrix(0.99999791,-0.00204595,0.00204595,0.99999791,0,0)" + x="756.18549" + y="1047.5868">NADPH+H</text> +<text + style="font-size:16.00077438px;font-family:Calibri-Bold" + id="text856" + class="st15 st16" + transform="matrix(0.99995156,0.00984282,-0.00984282,0.99995156,0,0)" + x="919.18933" + y="1061.8497">10-formylTHF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 895.7,1056.5186 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z m 2.4,14.1 c 7.3,-2 7.3,-2 7.3,-2 l -7.2,-2.3 1.8,2.2 -1.9,2.1 z" + class="st73" + inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297_2 forward" + inkscape:connector-curvature="0" + id="F_MTHFD1_AL445665_1_AQP7P4_LOC286297_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 888.6,1068.8186 c 5.3,-1.4 5.2,-17.3 5.2,-17.3 m -19.7,1.5 c -2.9,9.6 3.1,16 3.1,16 m 22.5,-0.1 -34.2,0" + class="st79" + inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297_2" + inkscape:connector-curvature="0" + id="R_MTHFD1_AL445665_1_AQP7P4_LOC286297_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 875.1,1056.9186 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z m -7.6,9.7 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z" + class="st73" + inkscape:label="MTHFD1_AL445665_1_AQP7P4_LOC286297_2 backward" + inkscape:connector-curvature="0" + id="B_MTHFD1_AL445665_1_AQP7P4_LOC286297_2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text861" + class="st15 st16" + transform="matrix(0.9999915,0.00412203,-0.00412203,0.9999915,0,0)" + x="805.01166" + y="1025.8337">mTHF</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.3247" + d="m 900.4,1026.9186 c 5.3,-1.1 5.2,-13.8 5.2,-13.8 m -19.8,1.2 c -3,7.7 3.2,12.8 3.2,12.8 m 44.5,25.3 0.6,-25.4 -84.3,-0.1" + class="st82" + inkscape:connector-curvature="0" + id="R_MTHFD1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 853.1,1024.7186 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z m 33.5,-9 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" + class="st73" + inkscape:connector-curvature="0" + id="F_MTHFD1_2" /><text + style="font-size:10px;font-family:Calibri" + id="text865" + class="st17 st18" + transform="matrix(0.99999985,5.3982362e-4,-5.3982362e-4,0.99999985,0,0)" + x="876.94342" + y="1005.7078">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text867" + class="st17 st26" + transform="matrix(0.99999985,5.3982362e-4,-5.3982362e-4,0.99999985,0,0)" + x="883.17377" + y="1007.7078">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text869" + class="st17 st18" + transform="matrix(0.99999985,5.3982362e-4,-5.3982362e-4,0.99999985,0,0)" + x="886.2627" + y="1005.7078">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 931.6,1049.1186 c 2.2,6.3 2.2,6.3 2.2,6.3 l 1.7,-6.5 -1.9,1.7 -2,-1.5 z m -24.1,-33.9 c -1.3,-7 -1.3,-7 -1.3,-7 l -1.9,6.9 1.7,-1.6 1.5,1.7 z" + class="st73" + inkscape:connector-curvature="0" + id="B_MTHFD1_2" /><text + style="font-size:16.00037193px;font-family:Calibri-Bold" + id="text872" + class="st15 st16" + transform="matrix(0.99997671,0.00682482,-0.00682482,0.99997671,0,0)" + x="707.71307" + y="1025.7979">meTHF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 791.2,1026.6186 -34.2,0 m 26.8,-15.4 c 2.6,9.7 -3.7,15.9 -3.7,15.9 m -11.3,-0.6 c -5.3,-1.6 -4.6,-17.4 -4.6,-17.4" + class="st79" + inkscape:connector-curvature="0" + id="R_MTHFD2_4" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 762.1,1013.9186 c 1.5,-7 1.5,-7 1.5,-7 l 1.7,6.9 -1.6,-1.7 -1.6,1.8 z m -3.3,10.5 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z" + class="st73" + inkscape:connector-curvature="0" + id="F_MTHFD2_4" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 789.6,1028.4186 c 7.3,-2 7.3,-2 7.3,-2 l -7.2,-2.3 1.8,2.2 -1.9,2.1 z m -6.7,-13.3 c 1.5,-7 1.5,-7 1.5,-7 l 1.7,6.9 -1.6,-1.7 -1.6,1.8 z" + class="st73" + inkscape:connector-curvature="0" + id="B_MTHFD2_4" /><text + style="font-size:10px;font-family:Calibri" + id="text877" + class="st17 st18" + transform="matrix(0.99989917,0.01420008,-0.01420008,0.99989917,0,0)" + x="790.88013" + y="994.28802">NADPH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text879" + class="st17 st18" + transform="matrix(0.99990781,0.01357832,-0.01357832,0.99990781,0,0)" + x="760.42932" + y="995.04498">NADP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text881" + class="st15 st16" + x="315.19269" + y="786.4632">OAA</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text883" + class="st15 st16" + x="942.22101" + y="658.15649">Gln</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text885" + class="st15 st16" + x="1033.4213" + y="658.15649">Glu</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.56400001" + d="m 969.4,653.91855 53.9,0 m -19.5,0.5 c 4.6,-0.4 6.2,-11.9 6.2,-11.9 m -5.5,11.7 c -4.5,0.5 -6.6,11.7 -6.6,11.7" + class="st83" + inkscape:label="GLS2" + inkscape:connector-curvature="0" + id="R_GLS2" /><text + style="font-size:10px;font-family:Calibri" + id="text888" + class="st17 st18" + x="1000.8987" + y="636.82635">NH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text890" + class="st17 st26" + x="1013.5844" + y="638.82635">3</text> +<text + style="font-size:10px;font-family:Calibri" + id="text892" + class="st17 st18" + x="983.43292" + y="674.4173">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text894" + class="st17 st26" + x="989.66345" + y="676.4173">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text896" + class="st17 st18" + x="992.7522" + y="674.4173">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text898" + class="st17 st18" + x="1035.5336" + y="601.31757">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text900" + class="st17 st18" + x="1022.9135" + y="638.01587">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text902" + class="st17 st18" + x="989.93292" + y="602.9173">NH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text904" + class="st17 st26" + x="1002.6184" + y="604.9173">3</text> +<text + style="font-size:10px;font-family:Calibri" + id="text906" + class="st17 st18" + x="980.08435" + y="638.513">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.11560011" + d="m 1050.4,645.51855 0,-29.9 -92.5,0 0,24 m 78.9,-24.4 c 5,-1.2 4.3,-13.1 4.3,-13.1 m -4.2,12.8 c -5.2,1 -5.3,9.2 -5.3,9.2 m -44,-8.8 c -3.7,0.9 -3.8,9 -3.8,9 m 11,-8.5 c 5,-1.1 4.3,-12 4.3,-12" + class="st84" + inkscape:label="#R_gln_synthetase" + inkscape:connector-curvature="0" + id="R_GS" /><path + style="fill:none;stroke:#000000;stroke-width:1.39260006" + d="m 956.3,660.51855 0,32.4 m 0.4,-9.9 c -2.6,2.5 9.5,6.9 9.5,6.9 m -10,-12.7 c 0.4,-4.4 -9.3,-7.5 -9.3,-7.5" + class="st85" + inkscape:label="TransportGln" + inkscape:connector-curvature="0" + id="R_TransportGln" /><path + style="fill:none;stroke:#000000;stroke-width:1.12300003" + d="m 1052,660.31855 0,32.2 m 0.1,-12.3 c 0.1,5.1 9.8,8.5 9.8,8.5 m -9.9,-9.3 c 0.2,-4.1 -8.4,-8.3 -8.4,-8.3" + class="st86" + inkscape:label="TransportGlu" + inkscape:connector-curvature="0" + id="R_TransportGlu" /><text + style="font-size:9.87795448px;font-family:Calibri" + id="text911" + class="st17 st87" + transform="scale(1.0123241,0.98782595)" + x="926.31677" + y="681.64825">H</text> +<text + style="font-size:9.87795448px;font-family:Calibri" + id="text913" + class="st17 st87" + transform="scale(1.0123241,0.98782595)" + x="962.82196" + y="702.19128">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text915" + class="st17 st18" + x="1032.5765" + y="674.64575">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text917" + class="st17 st18" + x="1070.2865" + y="694.58521">H</text> +<text + style="font-size:15.80470657px;font-family:Calibri-Bold" + id="text919" + class="st15 st88" + transform="scale(1.0123241,0.98782595)" + x="932.36621" + y="721.383">Gln</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text921" + class="st15 st16" + x="1040.6478" + y="712.59686">Glu</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09260011" + d="m 969.6,707.11855 63.5,0 m -30.7,0.2 c 5.9,-0.2 7.8,-7.5 7.8,-7.5 m -12.1,7.6 c -4.6,-0.4 -6.8,-9.9 -6.8,-9.9" + class="st89" + inkscape:connector-curvature="0" + id="R_GLS" /><text + style="font-size:10px;font-family:Calibri" + id="text924" + class="st17 st18" + x="1006.3949" + y="693.48657">NH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text926" + class="st17 st26" + x="1019.0804" + y="695.48657">3</text> +<text + style="font-size:10px;font-family:Calibri" + id="text928" + class="st17 st18" + x="982.98663" + y="694.27856">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text930" + class="st17 st26" + x="989.2171" + y="696.27856">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text932" + class="st17 st18" + x="992.30591" + y="694.27856">O</text> +<text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text934" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1331.6912" + y="771.82178">NH</text> +<text + style="font-size:9.7501936px;font-family:Calibri-Bold" + id="text936" + class="st15 st40" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1352.3239" + y="775.02191">3</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.76709998" + d="m 1189,777.11855 0.5,-30.4 m 10.5,7.1 c -8.9,1.1 -11.1,9.1 -11.1,9.1 m 0.2,-0.1 c -0.5,5.2 10.5,8.6 10.5,8.6" + class="st90" + inkscape:connector-curvature="0" + id="R_OTC_LEFTY1" /><text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text939" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1180.2643" + y="782.81091">Orn</text> +<text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text941" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1187.484" + y="728.58057">Ci</text> +<text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text943" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1187.3484" + y="635.12445">Ci</text> +<text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text945" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1153.5397" + y="588.43402">ArgSuc</text> +<text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text947" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1223.7125" + y="571.21527">Arg</text> +<text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text949" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1230.6833" + y="630.91748">Orn</text> +<text + style="font-size:10px;font-family:Calibri" + id="text951" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="1132.3175" + y="625.07318">Asp</text> +<text + style="font-size:10px;font-family:Calibri" + id="text953" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="1147.2687" + y="625.07312">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text955" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="1152.249" + y="625.07312">ATP</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text957" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1113.4318" + y="629.14063">AMP</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text959" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1132.9337" + y="629.1405">+</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text961" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1137.9142" + y="629.14056">PPi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.0948" + d="m 1179.6,616.11855 c -2.6,-4.9 -15,-1.2 -15,-1.2 m 1.5,11.8 c 10.1,0.2 14.5,-7.4 14.5,-7.4 m -1.1,-15.4 c -3,15.1 4.9,26.9 4.9,26.9" + class="st76" + inkscape:label="ASS1 " + inkscape:connector-curvature="0" + id="R_ASS1" /><text + style="font-size:10.00030041px;font-family:Calibri" + id="text964" + class="st17 st18" + transform="matrix(0.99427012,-0.10689679,0.10689679,0.99427012,0,0)" + x="1114.6914" + y="680.83099">Fum</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.79009998" + d="m 1214.6,571.01855 c -16.6,-3.2 -28.6,8.8 -28.6,8.8 m 7.5,-5.6 c 5.9,-1.9 4.1,-12.3 4.1,-12.3" + class="st91" + inkscape:connector-curvature="0" + id="R_ASL_CRCP" /><path + style="fill:none;stroke:#000000;stroke-width:1.92120004" + d="m 1248.2,621.11855 c 4.6,-20.3 -6.2,-36.5 -6.2,-36.5 m 18.6,3.2 c -9,-1.2 -13.6,6 -13.6,6 m 0.3,3.6 c 2,3.5 14.6,1.8 14.6,1.8" + class="st92" + inkscape:connector-curvature="0" + id="R_ARG2_ARG1" /><text + style="font-size:9.99962234px;font-family:Calibri" + id="text968" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1254.6495" + y="601.48828">H</text> +<text + style="font-size:6.09346962px;font-family:Calibri" + id="text970" + class="st17 st26" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1260.88" + y="603.48834">2</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text972" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1263.9689" + y="601.48822">O</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text974" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1262.8811" + y="616.68073">Urea</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1186.7,576.11855 c -4.8,5.9 -4.8,5.9 -4.8,5.9 l 7.2,-2.4 -2.7,-0.7 0.3,-2.8 z" + class="st73" + inkscape:label="ASL_CRCP backward" + inkscape:connector-curvature="0" + id="B_ASL_CRCP" /><path + style="fill:none;stroke:#000000;stroke-width:1.3319" + d="m 1199,562.51855 c -1.6,-4.9 -1.6,-4.9 -1.6,-4.9 l -1,4.9 1.2,-1.2 1.4,1.2 z m 11.8,10.5 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.1 1.8,2.1 -1.8,2.2 z" + class="st93" + inkscape:label="ASL_CRCP forward" + inkscape:connector-curvature="0" + id="F_ASL_CRCP" /><path + style="fill:none;stroke:#000000;stroke-width:2.13980007" + d="m 1190.5,651.51855 0.1,71.7 m -0.3,-53.8 c 2.4,5.4 15.3,4 15.3,4 m -15.4,-12.9 c 2.4,5.4 15.3,4 15.3,4 m -14.9,35.9 c 1.9,-5.6 15,-5.4 15,-5.4 m -14.6,17.1 c 1.9,-5.6 15,-5.4 15,-5.4" + class="st94" + inkscape:label="SLC25A15_SLC25A2_1" + inkscape:connector-curvature="0" + id="R_SLC25A15_SLC25A2_1" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text979" + class="st15 st38" + transform="matrix(0.99980805,-0.01959226,0.01959226,0.99980805,0,0)" + x="1201.152" + y="721.48889">H</text> +<text + style="font-size:13.99942493px;font-family:Calibri-Bold" + id="text981" + class="st15 st38" + transform="matrix(0.99984109,-0.01782667,0.01782667,0.99984109,0,0)" + x="1201.3977" + y="733.09906">Orn</text> +<text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text983" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1287.2751" + y="577.22217">Putr</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.36409998" + d="m 1256.3,636.01855 41.1,0 0,-40.3 m 10.7,7.5 c -6.7,-1.2 -10.2,6.1 -10.2,6.1" + class="st95" + inkscape:connector-curvature="0" + id="R_OGDH_ODC1_OGDHL" /><text + style="font-size:9.99962234px;font-family:Calibri" + id="text986" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1308.797" + y="620.35846">CO</text> +<text + style="font-size:6.09346962px;font-family:Calibri" + id="text988" + class="st17 st26" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1320.6622" + y="622.35846">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text990" + class="st15 st16" + x="1340.1732" + y="712.76776">GluSA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text992" + class="st17 st18" + x="1268.7523" + y="692.13495">AKG</text> +<text + style="font-size:10px;font-family:Calibri" + id="text994" + class="st17 st18" + x="1299.0814" + y="692.05975">Glu</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1306.2,700.71855 c -1.4,-7 -1.4,-7 -1.4,-7 l -1.7,6.9 1.6,-1.7 1.5,1.8 z m 21.3,8.8 c 6.3,-2.2 6.3,-2.2 6.3,-2.2 l -6.5,-1.7 1.7,1.9 -1.5,2 z" + class="st73" + inkscape:connector-curvature="0" + id="F_OAT" /><path + style="fill:none;stroke:#000000;stroke-width:2.21600008" + d="m 1239.8,707.61855 88.2,0.1 m -28.6,-0.2 c 5.4,-0.7 4.9,-7.6 4.9,-7.6 m -21.6,-4.9 c -1.9,7.9 4.4,12.5 4.4,12.5" + class="st96" + inkscape:connector-curvature="0" + id="R_OAT" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1359,688.51855 c 2.3,6.3 2.3,6.3 2.3,6.3 l 1.7,-6.5 -1.9,1.7 -2.1,-1.5 z" + class="st73" + inkscape:label="Transport_Lglu5semialdehyde backward" + inkscape:connector-curvature="0" + id="B_Transport_Lglu5semialdehyde" /><path + style="fill:none;stroke:#000000;stroke-width:2.34100008" + d="m 1361,668.81855 0.2,20" + class="st97" + inkscape:label="Transport_Lglu5semialdehyde " + inkscape:connector-curvature="0" + id="R_Transport_Lglu5semialdehyde" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1362.8,670.21855 c -0.7,-2.4 -1.3,-4.9 -2,-7.3 -0.8,2.4 -1.5,4.8 -2.3,7.3 0.7,-0.6 1.5,-1.2 2.2,-1.8 0.7,0.6 1.4,1.2 2.1,1.8 z" + class="st73" + inkscape:label="Transport_Lglu5semialdehyde forward" + inkscape:connector-curvature="0" + id="F_Transport_Lglu5semialdehyde" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1001" + class="st15 st16" + x="1336.557" + y="658.23456">GluSA</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1358.4,637.01855 c 2,6.4 2,6.4 2,6.4 l 1.9,-6.4 -1.9,1.6 -2,-1.6 z" + class="st73" + inkscape:label="ALDH4A1_2 backward" + inkscape:connector-curvature="0" + id="B_ALDH4A1_2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1004" + class="st15 st16" + x="1352.6332" + y="608.19745">P5C</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.24119997" + d="m 1360.4,618.41855 0.1,20.4 m 0.1,-8.4 c -3,-6.6 -10.4,-6.2 -10.4,-6.2" + class="st98" + inkscape:connector-curvature="0" + id="R_ALDH4A1_2" /><text + style="font-size:9.99962234px;font-family:Calibri" + id="text1007" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1319.298" + y="638.0332">H</text> +<text + style="font-size:6.09346962px;font-family:Calibri" + id="text1009" + class="st17 st26" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1325.5284" + y="640.03333">2</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text1011" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1328.6173" + y="638.03326">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1013" + class="st17 st18" + transform="matrix(0.99990761,-0.01359275,0.01359275,0.99990761,0,0)" + x="1371.2954" + y="643.84912">NADH+H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1015" + class="st17 st18" + transform="matrix(0.99939509,-0.03477735,0.03477735,0.99939509,0,0)" + x="1397.1116" + y="673.6972">NAD</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1017" + class="st15 st16" + x="1442.0248" + y="606.54315">Pro</text> +<text + style="font-size:10.00029469px;font-family:Calibri" + id="text1019" + class="st17 st18" + transform="matrix(0.99987054,0.01609049,-0.01609049,0.99987054,0,0)" + x="1389.0287" + y="630.53644">NADPH+H</text> +<text + style="font-size:9.99974251px;font-family:Calibri" + id="text1021" + class="st17 st18" + transform="matrix(0.99922571,-0.03934428,0.03934428,0.99922571,0,0)" + x="1378.6187" + y="707.83429">NADP</text> +<text + style="font-size:9.99983883px;font-family:Calibri" + id="text1023" + class="st17 st18" + transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" + x="1286.8578" + y="776.54065">NADH</text> +<text + style="font-size:9.99983883px;font-family:Calibri" + id="text1025" + class="st17 st18" + transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" + x="1311.4819" + y="776.54071">+</text> +<text + style="font-size:9.99983883px;font-family:Calibri" + id="text1027" + class="st17 st18" + transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" + x="1316.4624" + y="776.54065">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1029" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="1303.4719" + y="727.08441">NAD+H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1031" + class="st17 st26" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="1333.0753" + y="729.08441">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1033" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="1336.1642" + y="727.08441">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.78269994" + d="m 1360.8,720.31855 0.3,32.5 m -0.2,-19.6 c -1.4,-5 -10.8,-3.5 -10.8,-3.5 m 0.6,11.6 c 7.1,2 10.7,-4.9 10.7,-4.9" + class="st99" + inkscape:connector-curvature="0" + id="R_ALDH4A1_1" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1036" + class="st15 st16" + x="1350.3373" + y="771.66528">Glu</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1358.9,750.41855 c 2.3,6.3 2.3,6.3 2.3,6.3 l 1.7,-6.5 -1.9,1.7 -2.1,-1.5 z m -6.9,-10.7 c -7.1,0.9 -7.1,0.9 -7.1,0.9 l 6.8,2.3 -1.6,-1.8 1.9,-1.4 z" + class="st73" + inkscape:connector-curvature="0" + id="B_ALDH4A1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1351,728.11855 c -6.9,1.7 -6.9,1.7 -6.9,1.7 l 7,1.5 -1.8,-1.6 1.7,-1.6 z m 11.8,-3.7 c -0.7,-2.4 -1.3,-4.9 -2,-7.3 -0.8,2.4 -1.5,4.8 -2.3,7.3 0.7,-0.6 1.5,-1.2 2.2,-1.8 0.7,0.5 1.4,1.2 2.1,1.8 z" + class="st73" + inkscape:connector-curvature="0" + id="F_ALDH4A1_1" /><text + style="font-size:10px;font-family:Calibri" + id="text1040" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="888.26978" + y="706.72406">NAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1042" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="906.66333" + y="706.72406">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1044" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="888.2688" + y="719.22406">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1046" + class="st17 st26" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="894.50018" + y="721.22406">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1048" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="897.58905" + y="719.224">O</text> +<text + style="font-size:9.99983883px;font-family:Calibri" + id="text1050" + class="st17 st18" + transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" + x="824.83246" + y="730.75824">NADH+</text> +<text + style="font-size:9.99983883px;font-family:Calibri" + id="text1052" + class="st17 st18" + transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" + x="824.83344" + y="743.2583">H+NH</text> +<text + style="font-size:6.0936017px;font-family:Calibri" + id="text1054" + class="st17 st26" + transform="matrix(0.99971611,-0.02382647,0.02382647,0.99971611,0,0)" + x="848.72894" + y="745.25824">3</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 935,761.21855 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.7 -1.6,-1.6 z m -171.9,-16.2 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" + class="st73" + inkscape:connector-curvature="0" + id="B_GLUD1_GLUD2_2" /><path + style="fill:none;stroke:#000000;stroke-width:1.86580002" + d="m 941.8,747.41855 c -6.2,1.5 -5.1,14.4 -5.1,14.4 m 21.3,0.1 c 2.7,-9 -4.9,-14.5 -4.9,-14.5 m 103.9,-26.4 c 0,26.3 0,26.3 0,26.3 l -295.7,0" + class="st100" + inkscape:connector-curvature="0" + id="R_GLUD1_GLUD2_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1059,725.01855 c -2.3,-7.3 -2.3,-7.3 -2.3,-7.3 l -2.1,7.3 2.1,-1.9 2.3,1.9 z m -102.6,36.5 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.7 -1.6,-1.6 z" + class="st73" + inkscape:connector-curvature="0" + id="F_GLUD1_GLUD2_2" /><text + style="font-size:10px;font-family:Calibri" + id="text1059" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="956.75903" + y="773.34814">NADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1061" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="980.31866" + y="773.34814">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1063" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="956.75903" + y="785.84802">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1065" + class="st17 st26" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="962.9895" + y="787.84808">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1067" + class="st17 st18" + transform="matrix(0.99999215,0.00396135,-0.00396135,0.99999215,0,0)" + x="966.07831" + y="785.84814">O</text> +<text + style="font-size:9.99983883px;font-family:Calibri" + id="text1069" + class="st17 st18" + transform="matrix(0.99971611,-0.02382646,0.02382646,0.99971611,0,0)" + x="892.81866" + y="799.80231">NADPH+</text> +<text + style="font-size:9.99983883px;font-family:Calibri" + id="text1071" + class="st17 st18" + transform="matrix(0.99971611,-0.02382646,0.02382646,0.99971611,0,0)" + x="892.81866" + y="812.30237">H+NH</text> +<text + style="font-size:6.0936017px;font-family:Calibri" + id="text1073" + class="st17 st26" + transform="matrix(0.99971611,-0.02382646,0.02382646,0.99971611,0,0)" + x="916.71509" + y="814.30231">3</text> +<text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text1075" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="610.36102" + y="1009.088">Ser</text> +<text + style="font-size:15.99982166px;font-family:Calibri-Bold" + id="text1077" + class="st15 st16" + transform="matrix(0.99991115,-0.01332996,0.01332996,0.99991115,0,0)" + x="714.42944" + y="1011.3351">Gly</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1079" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="652.00781" + y="1022.0663">THF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 660.6,1009.4186 c 1.3,7 1.3,7 1.3,7 l 1.9,-6.9 -1.7,1.7 -1.5,-1.8 z m -2.4,-14.10005 c -7.3,2 -7.3,2 -7.3,2 l 7.3,2.3 -1.8,-2.2 1.8,-2.1 z" + class="st73" + inkscape:label="SHMT1_2 backward" + inkscape:connector-curvature="0" + id="B_SHMT1_2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1082" + class="st15 st16" + x="316.81769" + y="625.53351">Asp</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1084" + class="st15 st16" + x="317.24249" + y="728.39868">Asp</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1086" + class="st15 st16" + x="301.33231" + y="669.98846">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1088" + class="st15 st16" + x="289.33328" + y="654.96118">Glu</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1090" + class="st15 st16" + x="359.73318" + y="710.5979">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1092" + class="st15 st16" + x="356.95441" + y="697.87531">Glu</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.82299995" + d="m 330.6,717.91855 0.2,-81.5 m 0,65.8 c 1.9,5.9 17.6,4.4 17.6,4.4 m -34.6,-41.3 c 5,-3.9 17.8,4.8 17.8,4.8 m -17.9,-17.1 c 4.7,-4.2 18.1,3.8 18.1,3.8 m -1,32.6 c 1.9,5.9 17.6,4.4 17.6,4.4" + class="st45" + inkscape:label="SLC25A13_SLC25A12" + inkscape:connector-curvature="0" + id="R_SLC25A13_SLC25A12" /><path + style="fill:none;stroke:#000000;stroke-width:2.82299995" + d="m 345.2,696.41855 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.1 1.8,2.1 -1.8,2.2 z m -12.3,-57.1 c -2.3,-7.2 -2.3,-7.2 -2.3,-7.2 l -2,7.3 2.1,-1.9 2.2,1.8 z m 13.2,69.9 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.1 1.8,2.1 -1.8,2.2 z" + class="st45" + inkscape:label="#SLC25A13_SLC25A12" + inkscape:connector-curvature="0" + id="F_SLC25A13_SLC25A12" /><path + style="fill:none;stroke:#000000;stroke-width:2.49320006" + d="m 1491.4,754.31855 -49,-0.2" + class="st101" + inkscape:label="Transport_serine " + inkscape:connector-curvature="0" + id="R_Transport_serine" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1443.1,752.01855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" + class="st22" + inkscape:label="Transport_serine f" + inkscape:connector-curvature="0" + id="F_Transport_serine" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1098" + class="st15 st16" + x="1409.9398" + y="758.43781">Ser</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1100" + class="st15 st16" + x="1501.6996" + y="758.50806">Ser</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.48900008" + d="m 1490.5,773.81855 -48.1,-0.2" + class="st102" + inkscape:label="Transport_glycine " + inkscape:connector-curvature="0" + id="R_Transport_glycine" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1443.1,771.51855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" + class="st22" + inkscape:label="Transport_glycine backward" + inkscape:connector-curvature="0" + id="B_Transport_glycine" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1489.9,775.81855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" + class="st22" + inkscape:transform-center-y="-3.0492074" + inkscape:transform-center-x="0.87100132" + inkscape:label="Transport_glycine forward" + inkscape:connector-curvature="0" + id="F_Transport_glycine" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1105" + class="st15 st16" + x="1408.141" + y="776.79517">Gly</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1107" + class="st15 st16" + x="1502.0004" + y="777.33026">Gly</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.51880002" + d="m 1497,792.51855 -55.2,-0.2" + class="st103" + inkscape:label="TransportFolate" + inkscape:connector-curvature="0" + id="R_TransportFolate" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1442.5,790.21855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" + class="st22" + inkscape:label="TransportFolate f" + inkscape:connector-curvature="0" + id="F_TransportFolate" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1111" + class="st15 st16" + x="1386.1674" + y="797.35956">Folate</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1113" + class="st15 st16" + x="1501.8568" + y="795.38885">Folate</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.49620008" + d="m 1491.2,812.71855 -49.7,-0.2" + class="st104" + inkscape:label="SLC16A3_SLC16A1_SLC16A5_2 " + inkscape:connector-curvature="0" + id="R_SLC16A3_SLC16A1_SLC16A5_2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1116" + class="st15 st16" + x="1375.0873" + y="814.86646">Formate</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1118" + class="st15 st16" + x="1501.4066" + y="815.80499">Formate</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1120" + class="st17 st18" + x="485.40158" + y="115.15945">ATP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.0948" + d="m 467.4,101.01855 c 0,31.2 0,31.2 0,31.2 m 11.4,-18.7 c -7,-2.9 -11.5,3.3 -11.5,3.3 m 0.2,3.4 c 0.8,5.5 10.2,5.3 10.2,5.3" + class="st76" + inkscape:label="GCK_HKDC1_HK1_ADPGK_HK2_HK3 " + inkscape:connector-curvature="0" + id="R_GCK_HKDC1_HK1_ADPGK_HK2_HK3" /><path + style="fill:none;stroke:#000000;stroke-width:1.67910004" + d="m 467.6,565.81855 0,27.6 0,-27.6 z m 0,12.8 c 0.9,5 10.8,4.8 10.8,4.8 m 0.5,-11 c -6.9,-2.7 -11.3,3 -11.3,3" + class="st105" + inkscape:connector-curvature="0" + id="R_PKM_TMEM54_PKLR_HCN3" /><path + style="fill:none;stroke:#000000;stroke-width:2.0948" + d="m 467.4,210.91855 0,31.1 0,-31.1 z m 0.3,14.8 c 0.9,5.5 11.1,5.3 11.1,5.3 m 3.7,-11.9 c -8.8,-2.9 -14.6,3.3 -14.6,3.3" + class="st76" + inkscape:connector-curvature="0" + id="R_PFKP_PFKL_PFKM_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.0948" + d="m 463.2,324.21855 0,37.2 0,-37.2 z m -0.3,18.2 c 1,5.5 11.8,5.2 11.8,5.2 m 2.5,-13 c -8.1,-2.9 -13.4,3.3 -13.4,3.3" + class="st76" + inkscape:connector-curvature="0" + id="R_GAPDHS_GAPDH_GAPDHP29" /><path + style="fill:none;stroke:#000000;stroke-width:2.0948" + d="m 467.3,389.21855 0,37.2 0,-37.2 z m 0.4,15.4 c 0.8,5.6 9.7,5.3 9.7,5.3 m 2.5,-11.9 c -7.3,-3 -12,3.4 -12,3.4" + class="st76" + inkscape:connector-curvature="0" + id="R_CRISP3_PGK1_MIA3_PGK2" /><path + style="fill:none;stroke:#000000;stroke-width:1.81210005" + d="m 467,524.81855 c 1.1,4.4 13,4.2 13,4.2 m -13.1,-13 c 0,24.3 0,24.3 0,24.3" + class="st106" + inkscape:label="R_ENO1_ENO3_ENO2 " + inkscape:connector-curvature="0" + id="R_ENO1_ENO3_ENO2" /><path + style="fill:none;stroke:#000000;stroke-width:1.58019996" + d="m 479.9,153.01855 45.9,0 -45.9,0 z m 33,8.4 c 2.6,-5.3 -3.5,-8.6 -3.5,-8.6 m -16.6,0.1 c -4.9,1.2 -4.4,12.7 -4.4,12.7" + class="st107" + inkscape:connector-curvature="0" + id="R_G6PD" /><path + style="fill:none;stroke:#000000;stroke-width:1.53460002" + d="m 565.3,154.11855 c 7.9,0 15.7,0 23.6,0 m -8.7,0.1 c -1.9,0.2 -3.2,1.9 -3.9,3.4 -1.3,2.6 -1.9,5.6 -2.3,8.5" + class="st108" + inkscape:connector-curvature="0" + id="R_H6PD_PGLS" /><path + style="fill:none;stroke:#000000;stroke-width:1.82930005" + d="m 638.3,154.51855 46.1,0 -46.1,0 z m 36.6,9.4 c 2.4,-5.6 -3.7,-9.1 -3.7,-9.1 m -23.3,-0.2 c -5,1.1 -4.3,12 -4.3,12" + class="st109" + inkscape:connector-curvature="0" + id="R_PGD" /><path + style="fill:none;stroke:#000000;stroke-width:1.61259997" + d="m 968,293.11855 -0.2,25.4 m 12.8,-19.5 c -8.2,-1.5 -12.6,4.8 -12.6,4.8 m 0,2.6 c 1.7,4.8 13.1,3 13.1,3" + class="st110" + inkscape:label="CMPK2_CMPK1_1" + inkscape:connector-curvature="0" + id="R_CMPK2_CMPK1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.54340005" + d="m 759.4,333.41855 c 2.5,-0.6 3.4,-3.4 4,-5.6 0.5,-2.3 0.7,-4.7 0.7,-7 m -24.6,-0.6 c -1.6,4.5 -0.3,9.8 3.1,13.1 m -13.7,0 c 14.6,-0.1 29.2,-0.2 43.8,-0.3" + class="st111" + inkscape:connector-curvature="0" + id="R_TYMS" /><path + style="fill:none;stroke:#000000;stroke-width:1.75189996" + d="m 1088.6,332.81855 c 5.1,-1 3.8,-8.7 3.8,-8.7 m -24.6,-2.4 c -1.7,7.1 3.5,11.2 3.5,11.2 m -16.1,0 49.8,0.2" + class="st112" + inkscape:connector-curvature="0" + id="R_CTPS2_GATM_CTPS1" /><path + style="fill:none;stroke:#000000;stroke-width:1.82930005" + d="m 1146.5,332.61855 28.3,0.4 m -18.4,-9.2 c -2.2,5.6 3.9,8.9 3.9,8.9 m 4.8,0 c 5,-0.9 4,-8.9 4,-8.9" + class="st109" + inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" + inkscape:connector-curvature="0" + id="R_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_4" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1135" + class="st15 st38" + transform="matrix(0.99980805,-0.01959226,0.01959226,0.99980805,0,0)" + x="1196.0963" + y="700.7312">H</text> +<text + style="font-size:13.99942493px;font-family:Calibri-Bold" + id="text1137" + class="st15 st38" + transform="matrix(0.99984109,-0.01782667,0.01782667,0.99984109,0,0)" + x="1194.2786" + y="688.07074">Orn</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.52830005" + d="m 1425.4,612.11855 c 1,-2.3 0.5,-5 -1.1,-6.9 -0.6,-0.7 -1.2,-1.3 -1.9,-1.8 m -20,0.2 c -2.5,0.5 -3.6,3.7 -4.1,6.4 -0.3,2 -0.5,4.1 -0.4,6.1 m 34.9,-12.9 c -16.4,0.1 -32.8,0.1 -49.1,0.2" + class="st113" + inkscape:connector-curvature="0" + id="R_PYCRL_PYCR2_PYCR1_LEFTY1_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.80159998" + d="m 1428.9,640.21855 c 0.3,-6.1 -4.8,-8.7 -4.8,-8.7 m -22.3,0.4 c -3.9,-1.2 -5.4,12.6 -5.4,12.6 m -21.7,-31.8 0,19 75.8,0.1 0,-19" + class="st114" + inkscape:connector-curvature="0" + id="R_PYCRL_PYCR2_PYCR1_LEFTY1_2" /><path + style="fill:none;stroke:#000000;stroke-width:3.13759995" + d="m 1050.3,713.41855 c 0,26.9 0,26.9 0,26.9 l -293.5,0 m 98.1,-9.5 c -1.8,5.9 2.3,9.7 2.3,9.7 m 33.9,-0.2 c 3.4,-1.3 3.1,-14.8 3.1,-14.8" + class="st115" + inkscape:connector-curvature="0" + id="R_GLUD1_GLUD2_1" /><text + style="font-size:10px;font-family:Calibri" + id="text1142" + class="st17 st18" + transform="matrix(0.99999985,5.3982362e-4,-5.3982362e-4,0.99999985,0,0)" + x="904.09766" + y="1005.4383">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1144" + class="st15 st16" + x="1486.4927" + y="394.78244">PPi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1146" + class="st17 st18" + x="1531.7222" + y="374.82935">Pi</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1148" + class="st15 st16" + x="1554.2847" + y="394.81766">Pi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1150" + class="st17 st18" + x="1510.5044" + y="374.69266">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1152" + class="st17 st26" + x="1516.7349" + y="376.69266">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1154" + class="st17 st18" + x="1519.8237" + y="374.69266">O</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1156" + class="st15 st16" + x="1484.4966" + y="349.50125">CO</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text1158" + class="st15 st40" + x="1503.6685" + y="352.70145">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1160" + class="st15 st16" + x="1556.1343" + y="349.02563">HCO</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text1162" + class="st15 st40" + x="1585.3999" + y="352.22586">3</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text1164" + class="st15 st40" + x="1590.3413" + y="340.22586">-</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.80649996" + d="m 1525.5,346.01855 c -5.4,-1.7 -4.9,-14 -4.9,-14 m 10.8,14.3 c 5.5,-1.1 4.1,-10.6 4.1,-10.6 m 9,10.6 -33.9,-0.3" + class="st116" + inkscape:label="CA12_CA2_CA9_CA14_CA1_CA3_CA4_CA7_CA13" + inkscape:connector-curvature="0" + id="R_CA12_CA2_CA9_CA14_CA1_CA3_CA4_CA7_CA13" /><text + style="font-size:10px;font-family:Calibri" + id="text1167" + class="st17 st18" + x="1532.2759" + y="326.92114">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1169" + class="st17 st18" + x="1511.0825" + y="328.17014">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1171" + class="st17 st26" + x="1517.313" + y="330.17014">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1173" + class="st17 st18" + x="1520.4019" + y="328.17014">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1424.9,550.31855 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z m -9.1,-14.8 c -1.4,-7 -1.4,-7 -1.4,-7 l -1.8,6.9 1.6,-1.7 1.6,1.8 z" + class="st73" + inkscape:label="AGAT forward" + inkscape:connector-curvature="0" + id="F_AGAT" /><path + style="fill:none;stroke:#000000;stroke-width:2.16529989" + d="m 1402.1,532.41855 c -2.7,9.7 3.5,15.9 3.5,15.9 m 3.4,-0.2 c 5.4,-1.2 4.9,-14.2 4.9,-14.2 m -25.2,14.2 39.4,0.1" + class="st117" + inkscape:connector-curvature="0" + id="R_AGAT" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1391.4,546.31855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z m 11.6,-10 c -1.4,-7 -1.4,-7 -1.4,-7 l -1.8,6.9 1.6,-1.7 1.6,1.8 z" + class="st73" + inkscape:label="AGAT backward" + inkscape:connector-curvature="0" + id="B_AGAT" /><text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text1178" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1439.4275" + y="543.42334">Orn</text> +<text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text1180" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1360.4196" + y="542.20752">Arg</text> +<text + style="font-size:10.00020409px;font-family:Calibri" + id="text1182" + class="st17 st18" + transform="matrix(0.99997957,0.00639185,-0.00639185,0.99997957,0,0)" + x="1391.7148" + y="578.39606">H</text> +<text + style="font-size:6.09382439px;font-family:Calibri" + id="text1184" + class="st17 st26" + transform="matrix(0.99997957,0.00639185,-0.00639185,0.99997957,0,0)" + x="1397.9453" + y="580.39606">2</text> +<text + style="font-size:10.00020409px;font-family:Calibri" + id="text1186" + class="st17 st18" + transform="matrix(0.99997957,0.00639185,-0.00639185,0.99997957,0,0)" + x="1401.0333" + y="578.396">O</text> +<text + style="font-size:10.000103px;font-family:Calibri" + id="text1188" + class="st17 st18" + transform="matrix(0.99968968,0.0249107,-0.0249107,0.99968968,0,0)" + x="1421.3773" + y="552.20471">NH</text> +<text + style="font-size:6.09376287px;font-family:Calibri" + id="text1190" + class="st17 st26" + transform="matrix(0.99968968,0.0249107,-0.0249107,0.99968968,0,0)" + x="1434.0627" + y="554.20477">3</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.58570004" + d="m 1372.7,556.21855 0,8 59.7,0 m -27.9,0.1 c -5.2,1.1 -4.6,11.9 -4.6,11.9 m 11.8,-2.8 c 1.3,-5.8 -4.6,-9 -4.6,-9" + class="st118" + inkscape:connector-curvature="0" + id="R_arginineAmidinohydrolase" /><text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text1193" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1443.032" + y="560.49847">Ci</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1195" + class="st15 st16" + x="141.67799" + y="620.84399">Asn</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1197" + class="st17 st18" + x="169.63359" + y="597.4563">Glu</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1199" + class="st17 st18" + x="183.491" + y="597.4563">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1201" + class="st17 st18" + x="188.4715" + y="597.4563">AMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1203" + class="st17 st18" + x="207.97339" + y="597.4563">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1205" + class="st17 st18" + x="212.95389" + y="597.4563">PPi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1207" + class="st17 st18" + x="235.44168" + y="597.802">Gln+ATP+H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1209" + class="st17 st26" + x="280.53448" + y="599.802">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1211" + class="st17 st18" + x="283.6228" + y="597.802">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.13490009" + d="m 177.6,614.01855 c 45.3,0 90.7,0.1 136,0.1 m -53.3,-0.7 c 4.3,-2.2 4.3,-7.9 4.6,-12.1 l 0,-0.6 0,-0.5 m -62.9,4.2 c -1.9,3.5 0.5,7.2 3.5,9.1" + class="st119" + inkscape:connector-curvature="0" + id="R_ASNS" /><text + style="font-size:10px;font-family:Calibri" + id="text1214" + class="st17 st18" + x="178.00999" + y="646.13007">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1216" + class="st17 st26" + x="184.24049" + y="648.13007">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1218" + class="st17 st18" + x="187.32939" + y="646.13007">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1220" + class="st17 st18" + x="215.13109" + y="645.87531">NH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1222" + class="st17 st26" + x="227.8167" + y="647.87531">3</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1224" + class="st15 st16" + x="312.49149" + y="443.98465">Fum</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1226" + class="st15 st16" + x="311.30301" + y="503.79126">Mal</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1228" + class="st17 st18" + x="289.62579" + y="470.02274">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1230" + class="st17 st26" + x="295.8562" + y="472.02274">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1232" + class="st17 st18" + x="298.94458" + y="470.02274">O</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1234" + class="st15 st16" + x="310.03931" + y="565.5257">OAA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1236" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="364.86237" + y="538.48999">GTP</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text1238" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="378.13837" + y="544.30634">GDP+CO</text> +<text + style="font-size:6.09346962px;font-family:Calibri" + id="text1240" + class="st17 st26" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="412.61111" + y="546.30634">2</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.3204" + d="m 397.8,557.61855 c 6.3,-1 6,-11.8 6,-11.8 m -31.2,-3.5 c -2.3,9.4 2.6,15.5 2.6,15.5 m 62.1,-0.2 -98.3,0.2" + class="st120" + inkscape:connector-curvature="0" + id="R_PEPCK" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1243" + class="st15 st16" + x="562.0647" + y="582.62531">Iso</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1245" + class="st17 st18" + x="583.12042" + y="558.49048">NADPH</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1247" + class="st15 st16" + x="666.13904" + y="582.9212">AKG</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1249" + class="st17 st18" + x="584.34894" + y="600.24438">NADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1251" + class="st17 st18" + x="634.66632" + y="558.13007">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1253" + class="st17 st26" + x="646.53149" + y="560.13007">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1255" + class="st15 st16" + x="254.8035" + y="672.10089">Fum</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1257" + class="st17 st18" + x="235.65359" + y="644.21405">NH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1259" + class="st17 st26" + x="248.33908" + y="646.21405">3</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1261" + class="st15 st16" + x="354.87671" + y="645.8938">Ala</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 430.6,634.41855 c -1.4,-7 -1.4,-7 -1.4,-7 l -1.7,6.9 1.6,-1.7 1.5,1.8 z m 25.2,-8.7 c -2.2,-6.3 -2.2,-6.3 -2.2,-6.3 l -1.7,6.5 1.9,-1.7 2,1.5 z" + class="st73" + inkscape:label="NIT2 b" + inkscape:connector-curvature="0" + id="B_NIT2" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 410.3,635.21855 c -0.5,-2.3 -1,-4.7 -1.4,-7 -0.6,2.3 -1.2,4.6 -1.7,6.9 0.5,-0.6 1.1,-1.1 1.6,-1.7 0.4,0.6 1,1.2 1.5,1.8 l 0,0 z m -21.4,4.9 c -2.5,0.6 -4.9,1.3 -7.4,1.9 2.4,0.8 4.8,1.6 7.2,2.4 -0.6,-0.7 -1.2,-1.5 -1.8,-2.2 0.8,-0.7 1.4,-1.4 2,-2.1 l 0,0 z" + class="st73" + inkscape:label="NIT2" + inkscape:connector-curvature="0" + id="F_NIT2" /><text + style="font-size:10px;font-family:Calibri" + id="text1265" + class="st17 st18" + x="396.95239" + y="626.41815">AKG</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1267" + class="st17 st18" + x="420.85379" + y="626.40259">Glu</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1269" + class="st15 st16" + x="409.09311" + y="1219.8303">Biomass</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 434.5,1275.0186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" + class="st69" + inkscape:label="biomass_synthesis f" + inkscape:connector-curvature="0" + id="F_biomass_synthesis" /><path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 436.5,1224.9186 0,50.5" + class="st69" + inkscape:label="biomass_synthesis" + inkscape:connector-curvature="0" + id="R_biomass_synthesis" /><path + style="fill:none;stroke:#000000;stroke-width:1.68139994" + d="m 407.6,610.21855 c -5.4,-0.8 -5.1,-9.5 -5.1,-9.5 m 35.5,-3.8 c 2.8,7.9 -3.2,13.1 -3.2,13.1 m 14.4,-0.2 c -62.3,0 -62.3,0 -62.3,0" + class="st121" + inkscape:label="#R_LDHD" + inkscape:connector-curvature="0" + id="R_LDH" /><text + style="font-size:10px;font-family:Calibri" + id="text1274" + class="st17 st18" + x="657.13702" + y="176.49825">NADPH+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1276" + class="st17 st18" + x="657.13702" + y="188.99825">H+CO2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1278" + class="st17 st18" + x="498.32352" + y="174.68045">NADPH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1280" + class="st17 st18" + x="528.11365" + y="174.68045">+H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1282" + class="st17 st18" + x="420.31329" + y="593.42896">NADH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1284" + class="st17 st18" + x="444.93729" + y="593.42896">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1286" + class="st17 st18" + x="449.91779" + y="593.42896">H</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.90479994" + inkscape:connector-curvature="0" + d="m 467.5,711.91855 -0.2,-89.3 m 0.3,71.6 c 1.4,5.7 13.2,4.2 13.2,4.2 m -13.5,-30 c -1.7,-4.3 -14.4,-3.9 -14.4,-3.9" + class="st122" + id="R_MPC1_MPC2_MPC1L" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 465,710.11855 c 2.3,6.3 2.3,6.3 2.3,6.3 l 1.6,-6.5 -1.9,1.7 -2,-1.5 z" + class="st73" + inkscape:label="MPC1_MPC2_MPC1L forward" + inkscape:connector-curvature="0" + id="F_MPC1_MPC2_MPC1L" /><text + style="font-size:10px;font-family:Calibri" + id="text1290" + class="st17 st18" + x="432.4104" + y="750.59888">NAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1292" + class="st17 st18" + x="434.51151" + y="767.7298">CoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1294" + class="st17 st18" + x="485.1048" + y="782.6712">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1296" + class="st17 st26" + x="496.97" + y="784.6712">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1298" + class="st17 st18" + x="484.4744" + y="761.19745">NADH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1300" + class="st17 st18" + x="485.61499" + y="772.3714">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1302" + class="st17 st18" + x="580.08624" + y="699.8714">Mal</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1304" + class="st17 st18" + x="520.5755" + y="664.80096">Mal</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.25819993" + d="m 559.6,784.71855 -0.1,-252.5 m 0.1,159.4 c 1.4,5.6 13.3,4.2 13.3,4.2 m -13.4,-29.7 c -1.7,-4.2 -14.5,-3.9 -14.5,-3.9" + class="st123" + inkscape:label="SLC25A1" + inkscape:connector-curvature="0" + id="R_SLC25A1" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1307" + class="st15 st16" + x="554.77374" + y="523.11255">Cit</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 568.4,536.41855 c 2.2,-7.3 2.2,-7.3 2.2,-7.3 l 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" + class="st14" + inkscape:label="ACO1_IREB2 b" + inkscape:connector-curvature="0" + id="B_ACO1_IREB2" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 568.6,562.11855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" + class="st14" + inkscape:label="ACO1_IREB2 f" + inkscape:connector-curvature="0" + id="F_ACO1_IREB2" /><path + style="fill:none;stroke:#000000;stroke-width:1.92060006" + d="m 570.4,535.51855 c 0,27.3 0,27.3 0,27.3" + class="st124" + inkscape:label="ACO1_IREB2" + inkscape:connector-curvature="0" + id="R_ACO1_IREB2" /><text + style="font-size:10px;font-family:Calibri" + id="text1312" + class="st17 st18" + x="887.51202" + y="262.06564">2 Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 477.8,123.71855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -12.4,8 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" + class="st30" + inkscape:label="GCK_HKDC1_HK1_ADPGK_HK2_HK3 f" + inkscape:connector-curvature="0" + id="F_GCK_HKDC1_HK1_ADPGK_HK2_HK3" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 477.8,229.21855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -12,10.7 c 1.7,7.3 1.7,7.3 1.7,7.3 l 1.7,-7.3 -1.7,1.8 -1.7,-1.8 z" + class="st30" + inkscape:label="PFKP_PFKL_PFKM_1 f" + inkscape:connector-curvature="0" + id="F_PFKP_PFKL_PFKM_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 473.7,345.71855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -12.6,13.6 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" + class="st30" + inkscape:label="GAPDHS_GAPDH_GAPDHP29" + inkscape:connector-curvature="0" + id="F_GAPDHS_GAPDH_GAPDHP29" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 479.8,527.21855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -14.7,10.9 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" + class="st30" + inkscape:label="ENO1_ENO3_ENO2 f" + inkscape:connector-curvature="0" + id="F_ENO1_ENO3_ENO2" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 477.9,581.61855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -12.4,10.4 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z" + class="st30" + inkscape:label="PKM_TMEM54_PKLR_HCN3 f" + inkscape:connector-curvature="0" + id="F_PKM_TMEM54_PKLR_HCN3" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 403.9,602.11855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m -15.8,5.8 -7.3,2.2 7.3,2.2 -1.8,-2.2 1.8,-2.2 z" + class="st30" + inkscape:label="LDH f" + inkscape:connector-curvature="0" + id="F_LDH" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 514.9,160.51855 c -2,4.9 -2,4.9 -2,4.9 l -1.3,-5.6 1.6,1.7 1.7,-1 z m 6.5,-5.4 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.2 1.8,2.2 -1.8,2.2 z" + class="st30" + inkscape:label="G6PD" + inkscape:connector-curvature="0" + id="F_G6PD" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 676.8,162.21855 c -1,5.2 -1,5.2 -1,5.2 l -2.4,-5.3 1.9,1.3 1.5,-1.2 z m 5.2,-5.6 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.2 1.8,2.2 -1.8,2.2 z" + class="st30" + inkscape:label="PGD f" + inkscape:connector-curvature="0" + id="F_PGD" /><path + style="fill:none;stroke:#000000;stroke-width:2.09750009" + d="m 790.5,176.41855 c 0,29.5 0,29.5 0,29.5 m -12.7,-23.8 c 7.8,-2.3 12.6,3.5 12.6,3.5 m -0.3,7 c -1,5 -10.4,4.3 -10.4,4.3" + class="st125" + inkscape:label="PRPS2_PRPS1_PRPS1L1" + inkscape:connector-curvature="0" + id="R_PRPS2_PRPS1_PRPS1L1" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 764.8,168.11855 c 7.2,-0.3 7.2,-0.3 7.2,-0.3 l -6.1,-3.9 1.1,2.6 -2.2,1.6 z" + class="st32" + inkscape:transform-center-y="13.19671" + inkscape:transform-center-x="-17.870394" + inkscape:label="RPIA_LOC101060545 f" + inkscape:connector-curvature="0" + id="F_RPIA_LOC101060545" /><path + style="fill:none;stroke:#000000;stroke-width:1.17589998" + d="m 732.7,157.71855 33.8,8.2" + class="st126" + inkscape:transform-center-y="9.1713454" + inkscape:transform-center-x="7.5511886" + inkscape:label="RPIA_LOC101060545" + inkscape:connector-curvature="0" + id="R_RPIA_LOC101060545" /><path + style="fill:none;stroke:#000000;stroke-width:1.13479996" + d="m 739,148.51855 32,-6.4" + class="st127" + inkscape:transform-center-y="-9.5755519" + inkscape:transform-center-x="6.2972653" + inkscape:label="RPE_LOC729020" + inkscape:connector-curvature="0" + id="R_RPE_LOC729020" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 740.3,146.41855 c -6.6,2.9 -6.6,2.9 -6.6,2.9 l 7.1,1.5 -1.9,-2 1.4,-2.4 z" + class="st32" + inkscape:transform-center-y="-7.1245069" + inkscape:transform-center-x="22.076699" + inkscape:label="RPE_LOC729020 f" + inkscape:connector-curvature="0" + id="F_RPE_LOC729020" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 780.2,198.61855 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z m 12.4,6.6 c -2,6.9 -2,6.9 -2,6.9 l -2.4,-6.8 2.2,1.7 2.2,-1.8 z" + class="st30" + inkscape:label="PRPS2_PRPS1_PRPS1L1 f" + inkscape:connector-curvature="0" + id="F_PRPS2_PRPS1_PRPS1L1" /><text + style="font-size:10px;font-family:Calibri" + id="text1328" + class="st17 st18" + x="928.5589" + y="209.07054">4 Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.00309992" + d="m 628.9,518.91855 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m -6.4,-11.7 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 12.1,11.4 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 14.1,11.6 -72.4,-0.2 m 19.7,-0.3 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 1.3,-10.6 c 5.9,-1.4 5.4,-11.9 5.4,-11.9" + class="st128" + inkscape:label="ACLY" + inkscape:connector-curvature="0" + id="R_ACLY" /><text + style="font-size:10px;font-family:Calibri" + id="text1331" + class="st17 st18" + x="619.48761" + y="501.60864">Pi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1333" + class="st17 st18" + x="925.4632" + y="502.06665">CoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1335" + class="st17 st18" + x="978.2464" + y="502.37036">3ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1337" + class="st17 st18" + x="944.37335" + y="502.11053">2 NADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1339" + class="st17 st18" + x="1005.5902" + y="502.01004">Pi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1341" + class="st17 st18" + x="1022.222" + y="502.37036">CO2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1343" + class="st17 st18" + x="935.09015" + y="537.14966">2 NADPH</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.00309992" + d="m 990.8,518.11855 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 37.1,-11.1 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m -20.9,11.4 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m -56.6,11.1 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 5.6,-11.1 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 28.6,11.4 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 42.5,11.6 -117.3,-0.2 m 10.7,-0.3 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 4.3,-11 c 5.9,-1.4 5.4,-11.9 5.4,-11.9" + class="st128" + inkscape:label="MVD" + inkscape:connector-curvature="0" + id="R_MVD" /><text + style="font-size:10px;font-family:Calibri" + id="text1346" + class="st17 st18" + x="916.46899" + y="537.34601">2 H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1348" + class="st17 st18" + x="975.79724" + y="537.38495">3 ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1350" + class="st17 st18" + x="1083.433" + y="539.12915">2 ippPP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1352" + class="st17 st18" + x="1092.3324" + y="502.40256">2 PPi</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.96599996" + d="m 1113.5,519.01855 -25,-0.5 m 13.7,-0.2 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 1.2,-10.6 c 5.9,-1.4 5.4,-11.9 5.4,-11.9" + class="st129" + inkscape:label="ARID4B_GGPS1_FDPS_FDPSP7_2" + inkscape:connector-curvature="0" + id="R_ARID4B_GGPS1_FDPS_FDPSP7_2" /><text + style="font-size:10px;font-family:Calibri" + id="text1355" + class="st17 st18" + x="1146.4008" + y="536.18677">fPP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1357" + class="st17 st18" + x="1147.5316" + y="500.91135">15 H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1359" + class="st17 st26" + x="1166.1605" + y="502.91135">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1361" + class="st17 st18" + x="1169.2484" + y="500.91135">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1363" + class="st17 st18" + x="1244.015" + y="500.13596">2 PPi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1365" + class="st17 st18" + x="1178.6937" + y="500.73166">13 NADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1367" + class="st17 st18" + x="1269.6381" + y="499.95636">for</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1369" + class="st17 st18" + x="1219.3802" + y="500.49734">2 CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1371" + class="st17 st26" + x="1238.5746" + y="502.49734">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1373" + class="st17 st18" + x="1162.7885" + y="536.02271">13 NADPH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1375" + class="st17 st18" + x="1208.9027" + y="536.07941">16 H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1377" + class="st17 st18" + x="1230.308" + y="535.75806">10 O</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1379" + class="st17 st26" + x="1249.3265" + y="537.75806">2</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.82200003" + d="m 861.2,464.41855 c 5.9,-1 4.4,-9.6 4.4,-9.6 m -19,9.5 29.3,0.3 m -15.1,-0.1 c -6,1.2 -5.5,10.5 -5.5,10.5" + class="st130" + inkscape:label="MCAT_FASN" + inkscape:connector-curvature="0" + id="R_MCAT_FASN" /><text + style="font-size:10px;font-family:Calibri" + id="text1382" + class="st17 st18" + x="1064.4486" + y="447.78546">14 H</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 888.8,422.31855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -27.6,0.3 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 39.9,9.6 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" + class="st30" + inkscape:label="AcAcACPSynthesis f" + inkscape:connector-curvature="0" + id="F_AcAcACPSynthesis" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 477.8,777.11855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m 0,-10.5 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m 0,-10.5 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -10.5,38.3 c -2.1,6.9 -2.1,6.9 -2.1,6.9 l -2.3,-6.8 2.2,1.7 2.2,-1.8 z" + class="st30" + inkscape:label="DLD_PDHX_PDHA1_DLAT_PDHA2_PDHB F" + inkscape:connector-curvature="0" + id="F_DLD_PDHX_PDHA1_DLAT_PDHA2_PDHB" /><path + style="fill:none;stroke:#000000;stroke-width:2.37849998" + d="m 443.6,735.91855 -27.4,0 0,127.5 116.3,0 m -60.4,0.2 c 7.3,-1.5 7.3,-12.6 7.3,-12.6 m 17.7,12.5 c -7.6,1.4 -8.5,11 -8.5,11 m -25.1,-11 c -7.6,1.4 -8.5,11 -8.5,11 m -15.9,-11 c -7.6,1.4 -8.5,11 -8.5,11 m 8.7,-11.2 c 7.3,-1.5 7.3,-12.6 7.3,-12.6" + class="st131" + inkscape:label="PC" + inkscape:connector-curvature="0" + id="R_PC" /><text + style="font-size:10px;font-family:Calibri" + id="text1387" + class="st17 st18" + x="437.9422" + y="842.4212">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1389" + class="st17 st18" + x="475.73709" + y="842.85181">Pi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1391" + class="st17 st18" + x="420.13361" + y="882.27466">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1393" + class="st17 st18" + x="444.71021" + y="881.94067">HCO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1395" + class="st17 st26" + x="462.80591" + y="883.94067">3</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1397" + class="st17 st26" + x="465.89481" + y="876.44067">-</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1399" + class="st17 st18" + x="485.21021" + y="881.94067">H</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 530.5,861.11855 c 6.9,2.1 6.9,2.1 6.9,2.1 l -6.8,2.3 1.7,-2.2 -1.8,-2.2 z m -86,-10.4 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 33,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st32" + inkscape:label="PC f" + inkscape:connector-curvature="0" + id="F_PC" /><path + style="fill:none;stroke:#000000;stroke-width:1.53359997" + d="m 562.6,822.11855 c 4.2,1.1 4.2,1.1 4.2,1.1 l -4.4,1.6 1.2,-1.4 -1,-1.3 z m -6.5,-9.6 c 0.1,-5.5 0.1,-5.5 0.1,-5.5 l -3.5,4.6 2.1,-0.8 1.3,1.7 z" + class="st132" + inkscape:label="CS f" + inkscape:connector-curvature="0" + id="F_CS" /><text + style="font-size:10px;font-family:Calibri" + id="text1403" + class="st17 st18" + x="681.67023" + y="783.07056">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1405" + class="st17 st18" + x="683.4339" + y="716.35669">H</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.49890006" + d="m 662.8,725.01855 c -1,6.8 -7.1,8.5 -7.1,8.5 m 45.3,-7.2 c -1,6.8 -7.1,8.5 -7.1,8.5 m -8.9,-11 c -1,6.8 -7.1,8.5 -7.1,8.5 m -39,-5.5 c 1,6.8 7.1,8.5 7.1,8.5 m -13.6,3.7 c 26,-9.2 53,-8.9 79.3,1" + class="st133" + inkscape:label="IDH2" + inkscape:connector-curvature="0" + id="R_IDH2" /><path + style="fill:none;stroke:#000000;stroke-width:1.81630003" + d="m 638.9,767.21855 c -3.8,4 -3.8,4 -3.8,4 l 1.6,-6.8 0.4,2.8 1.8,0 z m -5.4,-13.8 c -6.3,-1.4 -6.3,-1.4 -6.3,-1.4 l 4.4,4.1 -0.4,-2 2.3,-0.7 z" + class="st134" + inkscape:label="IDH3 b" + inkscape:connector-curvature="0" + id="B_IDH3" /><path + style="fill:none;stroke:#000000;stroke-width:1.49890006" + d="m 632.4,755.01855 c 26,9.2 53,8.9 79.3,-1 m -74.1,13.2 c 1,-6.8 7.1,-8.5 7.1,-8.5 m 40.3,11 c -1,-6.8 -7.1,-8.5 -7.1,-8.5 m 23.1,6 c -1,-6.8 -7.1,-8.5 -7.1,-8.5 m -29.9,10.7 c -1,-6.8 -7.1,-8.5 -7.1,-8.5" + class="st133" + inkscape:connector-curvature="0" + id="R_IDH3" /><text + style="font-size:10px;font-family:Calibri" + id="text1410" + class="st17 st18" + x="789.9563" + y="767.94257">NADH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1412" + class="st17 st18" + x="814.58044" + y="767.94257">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1414" + class="st17 st18" + x="789.9563" + y="780.44257">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1416" + class="st17 st18" + x="796.18683" + y="780.44257">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1418" + class="st17 st18" + x="801.1673" + y="780.44257">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1420" + class="st17 st26" + x="813.03253" + y="782.44257">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1422" + class="st17 st18" + x="509.7952" + y="894.0257">NADH+H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1424" + class="st17 st18" + x="489.20441" + y="902.28931">NAD</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09549999" + d="m 429.3,916.81855 c -7.3,-1.3 -7.3,-10.9 -7.3,-10.9 m 29.9,10.9 c -7.3,-1.3 -7.3,-10.9 -7.3,-10.9 m 32.8,10.9 c -7.3,-1.3 -7.3,-10.9 -7.3,-10.9 m 22.9,10.8 c 7.3,-1.3 7.3,-10.9 7.3,-10.9 m 76.2,10.9 -167.7,0 0,-187.3 34.9,0" + class="st135" + inkscape:label="ME2_ME3_1" + inkscape:connector-curvature="0" + id="R_ME2_ME3_1" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 424,906.71855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 22.5,0 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 25.5,0 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m -31,-176.2 c 6.4,-2 6.4,-2 6.4,-2 l -6.6,-2.3 1.7,2.2 -1.5,2.1 z" + class="st30" + inkscape:label="ME2_ME3_1 f" + inkscape:connector-curvature="0" + id="F_ME2_ME3_1" /><text + style="font-size:10px;font-family:Calibri" + id="text1428" + class="st17 st18" + x="457.70239" + y="898.8313">NADH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1430" + class="st17 st18" + x="441.25998" + y="898.8313">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1432" + class="st17 st18" + x="415.7493" + y="898.8147">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1434" + class="st17 st26" + x="427.6145" + y="900.8147">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1436" + class="st17 st18" + x="503.78641" + y="944.25116">NADP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.14289999" + d="m 429.3,920.51855 c -7.3,1.4 -7.3,11.4 -7.3,11.4 m 29.9,-11.4 c -7.3,1.4 -7.3,11.4 -7.3,11.4 m 32.8,-11.4 c -7.3,1.4 -7.3,11.4 -7.3,11.4 m 38.1,-11.3 c 7.2,1.7 7.2,14.6 7.2,14.6 m 61.2,-14.6 -177,0 0,-199.5 42.5,0" + class="st136" + inkscape:label="ME2_ME3_2" + inkscape:connector-curvature="0" + id="R_ME2_ME3_2" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 424,930.01855 c -2,4.9 -2,4.9 -2,4.9 l -1.3,-5.6 1.6,1.7 1.7,-1 z m 22.5,0 c -2,4.9 -2,4.9 -2,4.9 l -1.3,-5.6 1.6,1.7 1.7,-1 z m 25.5,0 c -2,4.9 -2,4.9 -2,4.9 l -1.3,-5.6 1.6,1.7 1.7,-1 z m -31,-207 c 6.5,-1.8 6.5,-1.8 6.5,-1.8 l -6.5,-2.5 1.7,2.2 -1.7,2.1 z" + class="st30" + inkscape:label="ME2_ME3_2 f" + inkscape:connector-curvature="0" + id="F_ME2_ME3_2" /><text + style="font-size:10px;font-family:Calibri" + id="text1440" + class="st17 st18" + x="456.02231" + y="944.76099">NADPH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1442" + class="st17 st18" + x="440.8992" + y="944.5813">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1444" + class="st17 st18" + x="415.7981" + y="944.5813">CO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1446" + class="st17 st26" + x="427.66339" + y="946.5813">2</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.10339999" + d="m 615.9,579.61855 c 5.9,-1.5 5.4,-12.9 5.4,-12.9 m 15.5,12.5 c 5.9,-1.3 4.4,-12.5 4.4,-12.5 m 14,12.5 -72.4,-0.2 m 19.7,-0.3 c -5.9,1.4 -4.4,13.7 -4.4,13.7 m 1.3,-12.8 c 5.9,-1.5 5.4,-12.9 5.4,-12.9" + class="st137" + inkscape:label="IDH1" + inkscape:connector-curvature="0" + id="R_IDH1" /><text + style="font-size:10px;font-family:Calibri" + id="text1449" + class="st17 st18" + x="619.24744" + y="558.70239">H</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 327.8,483.61855 c 0,-27.3 0,-27.3 0,-27.3 m -0.4,15.6 c -1.1,-6 -11.6,-4.8 -11.6,-4.8" + class="st14" + inkscape:label="FH_2" + inkscape:connector-curvature="0" + id="R_FH_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 330.1,482.71855 c -2.2,7.3 -2.2,7.3 -2.2,7.3 l -2.2,-7.3 2.2,1.8 2.2,-1.8 z" + class="st14" + inkscape:label="FH_2 f" + inkscape:connector-curvature="0" + id="F_FH_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 329.9,456.91855 c -2.2,-7.3 -2.2,-7.3 -2.2,-7.3 l -2.2,7.3 2.2,-1.8 2.2,1.8 z m -14.7,12 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z" + class="st14" + inkscape:label="FH_2 b" + inkscape:connector-curvature="0" + id="B_FH_2" /><text + style="font-size:10px;font-family:Calibri" + id="text1454" + class="st17 st18" + x="287.3587" + y="527.83325">NAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1456" + class="st17 st18" + x="271.14529" + y="544.677">NADH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1458" + class="st17 st18" + x="295.76929" + y="544.677">+</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1460" + class="st17 st18" + x="300.74979" + y="544.677">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1462" + class="st15 st16" + x="429.36963" + y="1131.9838">Q</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1464" + class="st15 st16" + x="350.36279" + y="1132.7025">NADH</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1466" + class="st15 st16" + x="457.80908" + y="1199.7504">4 H</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.06859994" + d="m 474.1998,1181.2711 -2.8,5.9 -2,-6.1 2.3,1.6 2.5,-1.4 z m 12.4,-39.3 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z m 29.4,0 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z" + class="st138" + inkscape:label="Complex1ROS f" + inkscape:connector-curvature="0" + id="F_Complex1ROS" /><path + style="fill:none;stroke:#000000;stroke-width:2.06859994" + d="m 761.84776,1178.6878 -2.8,5.9 -2,-6.1 2.3,1.6 z m 27.25948,-37.9976 -2.8,-5.9 -2,6.1 2.3,-1.6 z m 52.82373,-0.1976 -2.8,-5.9 -2,6.1 2.3,-1.6 z" + class="st138" + inkscape:label="Complex3 f" + inkscape:connector-curvature="0" + id="F_Complex3" + sodipodi:nodetypes="ccccccccccccccc" /><path + style="fill:none;stroke:#000000;stroke-width:2.06859994" + d="m 1050.1,1177.9186 -2.8,5.9 -2,-6.1 2.3,1.6 2.5,-1.4 z m 96.4,-35.6 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z m -72,0 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z" + class="st138" + inkscape:label="Complex4 f" + inkscape:connector-curvature="0" + id="F_Complex4" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1471" + class="st15 st16" + x="1186.5951" + y="1132.6877">ADP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1473" + class="st15 st16" + x="1258.2738" + y="1131.0793">ATP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1475" + class="st15 st16" + x="1288.1302" + y="1131.2004">2 H</text> +<text + style="font-size:9.75px;font-family:Calibri-Bold" + id="text1477" + class="st15 st40" + x="1309.9506" + y="1134.3997">2</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1479" + class="st15 st16" + x="1314.8929" + y="1131.2004">O</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1481" + class="st15 st16" + x="1224.5297" + y="1132.1653">Pi</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1483" + class="st15 st16" + x="1234.349" + y="1192.5237">4 H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1485" + class="st15 st16" + x="1337.7094" + y="1131.2004">4 H</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.11870003" + d="m 1310.4,1155.6186 0,-13.8 m -106.2,-2 0,16.2 142.6,0 0,-16.2 m -116.3,-0.5 0,16.2 m 43.9,0.1 0,-13.8 m -29.7,13.8 0,25.4" + class="st139" + inkscape:label="ATPsynthase " + inkscape:connector-curvature="0" + id="R_ATPsynthase" /><path + style="fill:none;stroke:#000000;stroke-width:2.06859994" + d="m 1313.3,1141.9186 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z m 36,0 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z m -72,0 -2.8,-5.9 -2,6.1 2.3,-1.6 2.5,1.4 z" + class="st138" + inkscape:label="ATPsynthase f" + inkscape:connector-curvature="0" + id="F_ATPsynthase" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1495" + class="st15 st16" + x="177.9417" + y="839.77655">AKG</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1497" + class="st15 st16" + x="286.39868" + y="840.57635">AKG</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.82299995" + d="m 275.8,835.31855 -60.2,-0.3 m 44.6,0.3 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -26.7,14.1 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7" + class="st45" + inkscape:label="SLC25A11" + inkscape:connector-curvature="0" + id="R_SLC25A11" /><path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 267.4,821.81855 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -51.1,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 l 0,0 z" + class="st140" + inkscape:label="SLC25A11 b" + inkscape:connector-curvature="0" + id="B_SLC25A11" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1501" + class="st15 st38" + x="258.91681" + y="813.65851">Mal</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1503" + class="st15 st38" + x="218.61449" + y="814.12427">Mal</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.35560012" + d="m 233.9,824.21855 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m 40.1,13.1 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" + class="st46" + inkscape:label="SLC25A11 f" + inkscape:connector-curvature="0" + id="F_SLC25A11" /><text + style="font-size:10px;font-family:Calibri" + id="text1506" + class="st17 st18" + x="1286.9183" + y="796.95239">HCO</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1508" + class="st17 st26" + x="1305.014" + y="798.95239">3</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1510" + class="st17 st26" + x="1308.1029" + y="791.45239">-</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1512" + class="st17 st18" + x="1261.7601" + y="797.07349">2 ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1514" + class="st17 st18" + x="1312.8011" + y="797.28931">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1516" + class="st17 st18" + x="1215.6556" + y="796.61255">2 ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1518" + class="st17 st18" + x="1247.1156" + y="797.24536">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1198.1,755.61855 c 6.9,-1.7 6.9,-1.7 6.9,-1.7 l -7,-1.5 1.8,1.6 -1.7,1.6 z m -6.3,-8.1 c -1.9,-7.4 -1.9,-7.4 -1.9,-7.4 l -2.4,7.2 2.2,-1.8 2.1,2 z" + class="st73" + inkscape:label="OTC_LEFTY1 f" + inkscape:connector-curvature="0" + id="F_OTC_LEFTY1" /><text + style="font-size:10px;font-family:Calibri" + id="text1521" + class="st17 st18" + x="1207.1527" + y="756.75415">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1205.4,705.01855 c 5.4,1.6 5.4,1.6 5.4,1.6 l -5.8,1.7 1.6,-1.6 -1.2,-1.7 z m 0,-12 c 5.4,1.6 5.4,1.6 5.4,1.6 l -5.8,1.7 1.6,-1.6 -1.2,-1.7 z m -12.9,-39.4 c -2.6,-7.2 -2.6,-7.2 -2.6,-7.2 l -1.7,7.4 2,-2 2.3,1.8 z" + class="st73" + inkscape:label="SLC25A15_SLC25A2_1 f" + inkscape:connector-curvature="0" + id="F_SLC25A15_SLC25A2_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1165.5,612.21855 c -6.9,1.7 -6.9,1.7 -6.9,1.7 l 7,1.5 -1.8,-1.6 1.7,-1.6 z m 14.8,-3.2 c -0.8,-7.6 -0.8,-7.6 -0.8,-7.6 l -3.4,6.8 2.5,-1.4 1.7,2.2 z" + class="st73" + inkscape:label="ASS1 f" + inkscape:connector-curvature="0" + id="F_ASS1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1260.6,601.11855 c 6.9,-1.7 6.9,-1.7 6.9,-1.7 l -7,-1.5 1.8,1.6 -1.7,1.6 z m -14.1,15.4 c 0.8,7.6 0.8,7.6 0.8,7.6 l 3.4,-6.8 -2.4,1.4 -1.8,-2.2 z" + class="st73" + inkscape:label="ARG2_ARG1 f" + inkscape:connector-curvature="0" + id="F_ARG2_ARG1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1307.9,604.11855 c 6.9,-1.7 6.9,-1.7 6.9,-1.7 l -7,-1.5 1.8,1.6 -1.7,1.6 z m -8.3,-7.4 c -1.9,-7.4 -1.9,-7.4 -1.9,-7.4 l -2.4,7.2 2.2,-1.8 2.1,2 z" + class="st73" + inkscape:label="OGDH_ODC1_OGDHL f" + inkscape:connector-curvature="0" + id="F_OGDH_ODC1_OGDHL" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1410.9,573.21855 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z m 19,-6.5 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z" + class="st73" + inkscape:label="arginineAmidinohydrolase" + inkscape:connector-curvature="0" + id="F_arginineAmidinohydrolase" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1226.5,773.71855 -7.3,2.2 7.3,2.2 -1.8,-2.2 1.8,-2.2 z m 6.9,9 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z m 15.5,0.5 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z" + class="st73" + inkscape:label="CPS1" + inkscape:connector-curvature="0" + id="F_CPS1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1424.1,609.91855 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z m 7.6,-4.7 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z" + class="st73" + inkscape:label="PYCRL_PYCR2_PYCR1_LEFTY1_1 f" + inkscape:connector-curvature="0" + id="F_PYCRL_PYCR2_PYCR1_LEFTY1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1427.1,638.71855 c 1.7,6.9 1.7,6.9 1.7,6.9 l 1.5,-7 -1.6,1.8 -1.6,-1.7 z m 25.3,-21.9 c -1.8,-7.4 -1.8,-7.4 -1.8,-7.4 l -2.5,7.2 2.2,-1.7 2.1,1.9 z" + class="st73" + inkscape:label="PYCRL_PYCR2_PYCR1_LEFTY1_2 f" + inkscape:connector-curvature="0" + id="F_PYCRL_PYCR2_PYCR1_LEFTY1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 389.7,362.01855 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" + class="st73" + inkscape:connector-curvature="0" + id="path2280" /><path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 376.4,277.61855 c 1.4,5.3 17.3,5.1 17.3,5.1 m -78.9,-8.4 c 36.8,-1.5 60.9,1.7 60.9,1.7 m 0.6,47.2 -0.1,-55.9 m -15.7,21.2 c 9.7,-2.9 16,3.2 16,3.2" + class="st79" + inkscape:connector-curvature="0" + id="R_SHMT1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 314.9,275.71855 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z m 63.2,-8.2 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -14.8,22 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" + class="st73" + inkscape:connector-curvature="0" + id="F_SHMT1" /><text + style="font-size:9.99962234px;font-family:Calibri" + id="text1534" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="333.75421" + y="294.88434">H</text> +<text + style="font-size:6.09346962px;font-family:Calibri" + id="text1536" + class="st17 st26" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="339.98471" + y="296.88437">2</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text1538" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="343.07361" + y="294.8844">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 401.7,328.31855 c 1.3,-7 1.3,-7 1.3,-7 l 1.9,6.9 -1.7,-1.7 -1.5,1.8 z m 10.4,8.6 c 6.3,2.2 6.3,2.2 6.3,2.2 l -6.5,1.7 1.7,-1.9 -1.5,-2 z" + class="st73" + inkscape:label="SDS_SDSL_SRR" + inkscape:connector-curvature="0" + id="F_SDS_SDSL_SRR" /><path + style="fill:none;stroke:#000000;stroke-width:2.18140006" + d="m 453.8,622.71855 0,19.5 -67.5,0 m 23.1,-11 c -2.7,7 3.5,11.5 3.5,11.5 m 10.9,-0.1 c 5.4,-0.9 4.9,-10.3 4.9,-10.3" + class="st141" + inkscape:label="NIT2" + inkscape:connector-curvature="0" + id="R_NIT2" /><text + style="font-size:10px;font-family:Calibri" + id="text1542" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="301.05325" + y="582.61121">Glu</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text1544" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="288.98755" + y="601.8775">AKG</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 327.2,600.61855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m -7,-4.3 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" + class="st73" + inkscape:label="GOT1_GOT2_GOT1L1_2 bb" + inkscape:connector-curvature="0" + id="B_GOT1_GOT2_GOT1L1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.06480002" + d="m 329.3,603.91855 -0.2,-29.4 m -12.3,8.1 c 7.6,-2.9 12.6,3.3 12.6,3.3 m 0,3.4 c -0.9,5.5 -11.2,5.2 -11.2,5.2" + class="st142" + inkscape:label="GOT1_GOT2_GOT1L1_2" + inkscape:connector-curvature="0" + id="R_GOT1_GOT2_GOT1L1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 331,575.81855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -10.2,7.7 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" + class="st73" + inkscape:label="GOT1_GOT2_GOT1L1_2 f" + inkscape:connector-curvature="0" + id="F_GOT1_GOT2_GOT1L1_2" /><text + style="font-size:10px;font-family:Calibri" + id="text1549" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="302.24371" + y="760.4939">Glu</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text1551" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="288.6842" + y="751.92932">AKG</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 328.8,764.61855 c 2,7.3 2,7.3 2,7.3 l 2.3,-7.3 -2.2,1.8 -2.1,-1.8 z m -8,-4.3 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" + class="st73" + inkscape:label="GOT2_GOT1L1_1 b" + inkscape:connector-curvature="0" + id="B_GOT2_GOT1L1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.06480002" + d="m 330.9,768.01855 -0.2,-29.4 m -13.3,8.1 c 8.1,-2.9 13.4,3.3 13.4,3.3 m -0.1,3.3 c -1,5.4 -11.9,5.2 -11.9,5.2" + class="st142" + inkscape:label="GOT2_GOT1L1_1" + inkscape:connector-curvature="0" + id="R_GOT2_GOT1L1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 332.6,739.81855 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z m -11.2,7.7 c -7,-1.3 -7,-1.3 -7,-1.3 l 6.9,-1.9 -1.7,1.7 1.8,1.5 z" + class="st73" + inkscape:label="GOT2_GOT1L1_1 f" + inkscape:connector-curvature="0" + id="F_GOT2_GOT1L1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.5236001" + d="m 270.8,636.91855 c -1.4,6.1 -13.6,4.6 -13.6,4.6 m 58.1,-13.7 -44.2,0 0,24.1" + class="st143" + inkscape:label="FH_3" + inkscape:connector-curvature="0" + id="R_FH_3" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 203.3,605.11855 c -1.5,-5.1 -1.5,-5.1 -1.5,-5.1 l -1.8,5.5 1.7,-1.5 1.6,1.1 z m -25.5,6.7 c -6.3,2.2 -6.3,2.2 -6.3,2.2 l 6.5,1.7 -1.7,-1.9 1.5,-2 z" + class="st30" + inkscape:connector-curvature="0" + id="F_ASNS" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 306.6,623.91855 c 6.3,-2.2 6.3,-2.2 6.3,-2.2 l -6.5,-1.7 1.7,1.9 -1.5,2 z m -87.9,7 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" + class="st30" + inkscape:connector-curvature="0" + id="path2462" /><path + style="fill:none;stroke:#000000;stroke-width:2.5697" + d="m 174.6,621.51855 134,0.1 m -89.1,9.8 c 2.6,-5.3 -3.5,-9.1 -3.5,-9.1 m -23.9,-0.1 c -5,1.5 -4.6,13.1 -4.6,13.1" + class="st144" + inkscape:connector-curvature="0" + id="R_ASRGL1_ASPG" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 327.8,536.41855 c -1.1,6 -11.6,4.8 -11.6,4.8 m 11.6,5.6 c 0,-30.5 0,-30.5 0,-30.5 m 0,14.1 c -1.1,-6 -11.6,-4.8 -11.6,-4.8" + class="st14" + inkscape:label="MDH1_MDH1B " + inkscape:connector-curvature="0" + id="R_MDH1_MDH1B" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 315.6,539.51855 c -4.9,2 -4.9,2 -4.9,2 l 5.6,1.3 -1.7,-1.6 1,-1.7 z m 14.6,6.2 c -2.2,7.3 -2.2,7.3 -2.2,7.3 l -2.2,-7.3 2.2,1.8 2.2,-1.8 z" + class="st14" + inkscape:label="MDH1_MDH1B f" + inkscape:connector-curvature="0" + id="F_MDH1_MDH1B" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 329.9,517.91855 c -2.2,-7.3 -2.2,-7.3 -2.2,-7.3 l -2.2,7.3 2.2,-1.8 2.2,1.8 z m -14.3,9.5 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z" + class="st14" + inkscape:label="MDH1_MDH1B b" + inkscape:connector-curvature="0" + id="B_MDH1_MDH1B" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 853.3,730.91855 c 1.7,-6.9 1.7,-6.9 1.7,-6.9 l 1.5,7 -1.6,-1.7 -1.6,1.6 z m -94.9,7.7 c -7.3,2.3 -7.3,2.3 -7.3,2.3 l 7.3,2 -1.9,-2.1 1.9,-2.2 z" + class="st73" + inkscape:label="GLUD1_GLUD2_1 F" + inkscape:connector-curvature="0" + id="F_GLUD1_GLUD2_1" /><text + style="font-size:10px;font-family:Calibri" + id="text1564" + class="st17 st18" + x="843.83331" + y="243.37524">Asp</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1566" + class="st15 st16" + x="1104.5219" + y="229.47775">AMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1568" + class="st17 st18" + x="1032.9047" + y="239.12524">GTP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1570" + class="st17 st18" + x="1056.3265" + y="238.95825">Asp</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1572" + class="st17 st18" + x="1070.4886" + y="207.11935">Fum</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1574" + class="st17 st18" + x="1038.6117" + y="207.13495">GDP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1576" + class="st15 st16" + x="1190.1205" + y="274.58914">GMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1578" + class="st17 st18" + x="1022.7562" + y="251.87625">NAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1580" + class="st17 st18" + x="1044.2269" + y="251.96504">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1582" + class="st17 st26" + x="1050.4574" + y="253.96504">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1584" + class="st17 st18" + x="1053.5463" + y="251.96504">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1586" + class="st17 st18" + x="1096.4867" + y="251.55885">NADH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1588" + class="st17 st18" + x="1124.9867" + y="251.55885">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1590" + class="st17 st18" + x="1136.9867" + y="251.55885">AMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1592" + class="st17 st18" + x="1062.2269" + y="251.96504">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1594" + class="st17 st18" + x="1078.7269" + y="251.96504">NH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1596" + class="st17 st26" + x="1091.4125" + y="253.96504">3</text> +<path + style="fill:#786721;stroke:#000000;stroke-width:2.5" + d="m 1165.6,258.31855 c -1.6,-4.7 -1.6,-4.7 -1.6,-4.7 l -2.4,4.6 2.1,-1.1 1.9,1.2 z m 7.2,8.5 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -25.2,-8.5 c -1.6,-4.7 -1.6,-4.7 -1.6,-4.7 l -2.4,4.6 2.1,-1.1 1.9,1.2 z m -16.5,0 c -1.6,-4.7 -1.6,-4.7 -1.6,-4.7 l -2.4,4.6 2.1,-1.1 1.9,1.2 z m -21,0 c -1.6,-4.7 -1.6,-4.7 -1.6,-4.7 l -2.4,4.6 2.1,-1.1 1.9,1.2 z" + class="st145" + inkscape:label="GMPS f" + inkscape:connector-curvature="0" + id="F_GMPS" /><text + style="font-size:10px;font-family:Calibri" + id="text1599" + class="st17 st18" + x="1159.4867" + y="251.55885">PPi</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.45089996" + d="m 1017,234.51855 0,30 156.7,0 m -13.1,-0.1 c 4.8,-1 3,-7.4 3,-7.4 m -76.3,-1.9 c -1.5,6.1 4.8,9.3 4.8,9.3 m -24.3,-9.3 c -1.5,6.1 4.8,9.3 4.8,9.3 m 70,0 c 4.8,-1 3,-7.4 3,-7.4 m -19.5,7.4 c 4.8,-1 3,-7.4 3,-7.4 m -79.3,-1.9 c -1.5,6.1 4.8,9.3 4.8,9.3 m -19.7,-9.3 c -1.5,6.1 4.8,9.3 4.8,9.3 m 65.4,0 c 4.8,-1 3,-7.4 3,-7.4" + class="st146" + inkscape:label="GMPS" + inkscape:connector-curvature="0" + id="R_GMPS" /><text + style="font-size:10px;font-family:Calibri" + id="text1602" + class="st17 st18" + x="1089.4623" + y="295.44165">NADPH</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1126.6,282.21855 c -1.6,4.7 -1.6,4.7 -1.6,4.7 l -2.4,-4.6 2.1,1.1 1.9,-1.2 z m -18,0 c -1.6,4.7 -1.6,4.7 -1.6,4.7 l -2.4,-4.6 2.1,1.1 1.9,-1.2 z m 64,-4.2 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.3,-1.9 1.9,2.1 -1.8,2.2 z" + class="st22" + inkscape:connector-curvature="0" + id="path2738" /><text + style="font-size:10px;font-family:Calibri" + id="text1605" + class="st17 st18" + x="1122.9066" + y="295.62234">H</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1607" + class="st17 st18" + x="1045.0922" + y="295.91525">NADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1609" + class="st17 st18" + x="1070.9701" + y="295.55396">NH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1611" + class="st17 st26" + x="1083.6556" + y="297.55396">3</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.7529" + d="m 1076.8,287.31855 c -1.5,-7.6 4.8,-11.6 4.8,-11.6 m -24.2,11.6 c -1.5,-7.6 4.8,-11.6 4.8,-11.6 m 59.4,0.1 c 4.8,0.9 3,6.9 3,6.9 m -21,-6.9 c 4.8,0.9 3,6.9 3,6.9 m -95.6,-48.5 0,41.6 162.2,0" + class="st147" + inkscape:label="GMPR2_GMPR" + inkscape:connector-curvature="0" + id="R_GMPR2_GMPR" /><path + style="fill:none;stroke:#000000;stroke-width:1.92519999" + d="m 1257.8,269.81855 c -24.9,0 -24.9,0 -24.9,0 m 16.5,9.6 c 2.4,-5.9 -3.6,-9.5 -3.6,-9.5 m -2.6,0.1 c -5,0.9 -4.4,9.3 -4.4,9.3" + class="st148" + inkscape:label="GUK1_1" + inkscape:connector-curvature="0" + id="R_GUK1_1" /><text + style="font-size:10px;font-family:Calibri" + id="text1615" + class="st17 st18" + x="1305.1234" + y="296.55396">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1617" + class="st17 st26" + x="1311.3539" + y="298.55396">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1619" + class="st17 st18" + x="1314.4427" + y="296.55396">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.89830005" + d="m 1324,269.41855 c -24.2,0 -24.2,0 -24.2,0 m 15.6,11.1 c 2.4,-6.8 -3.6,-11 -3.6,-11" + class="st149" + inkscape:label="RRM2B_TXN_RRM1_RRM2B_1" + inkscape:connector-curvature="0" + id="R_RRM2B_TXN_RRM1_RRM2B_1" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1622" + class="st15 st16" + x="1336.0267" + y="274.81174">dGDP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1624" + class="st15 st16" + x="1189.1234" + y="226.54515">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1626" + class="st17 st18" + x="1144.3539" + y="205.21504">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1628" + class="st17 st18" + x="1162.7318" + y="204.82245">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1630" + class="st17 st18" + x="1225.3851" + y="248.99045">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1632" + class="st17 st26" + x="1231.6156" + y="250.99045">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1634" + class="st17 st18" + x="1234.7035" + y="248.99045">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.77349997" + d="m 1239.9,223.41855 c -21.1,0 -21.1,0 -21.1,0 m 12.6,11.4 c 2.4,-7 -3.6,-11.3 -3.6,-11.3" + class="st150" + inkscape:label="RRM2B_TXN_RRM1_RRM2B_2" + inkscape:connector-curvature="0" + id="R_RRM2B_TXN_RRM1_RRM2B_2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1637" + class="st15 st16" + x="1251.2035" + y="225.97145">dADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1639" + class="st17 st18" + x="989.38702" + y="354.02756">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1641" + class="st17 st18" + x="1006.057" + y="353.84204">ADP</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.82930005" + d="m 1014.9,334.41855 c 7.4,-1.9 7.4,-1.9 7.4,-1.9 l -7.2,-2.4 1.8,2.2 -2,2.1 z m -5.5,5.8 c 2.4,5.1 2.4,5.1 2.4,5.1 l 2,-5.2 -2.1,1.3 -2.3,-1.2 z" + class="st109" + inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3 b" + inkscape:connector-curvature="0" + id="B_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3" /><path + style="fill:none;stroke:#000000;stroke-width:1.55369997" + d="m 1004.5,332.21855 c -4.9,1.2 -3.1,9.2 -3.1,9.2 m 10.5,0.8 c 1.6,-6.3 -4.9,-9.6 -4.9,-9.6 m 10.9,-0.3 -25.4,-0.2" + class="st151" + inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3" + inkscape:connector-curvature="0" + id="R_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3" /><text + style="font-size:10px;font-family:Calibri" + id="text1645" + class="st17 st18" + x="484.89191" + y="128.75026">ADP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1647" + class="st15 st16" + x="448.1004" + y="156.49535">G6P</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1649" + class="st15 st16" + x="450.83908" + y="90.690155">Glc</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 465.3,424.91855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z m 11.2,-16.2 c 1.6,0.7 3.3,1.4 4.9,2 -1.9,0.4 -3.8,0.8 -5.6,1.3 0.6,-0.5 1.1,-1 1.7,-1.6 -0.4,-0.5 -0.7,-1.1 -1,-1.7 l 0,0 z" + class="st14" + inkscape:label="CRISP3_PGK1_MIA3_PGK2 f" + inkscape:connector-curvature="0" + id="F_CRISP3_PGK1_MIA3_PGK2" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 447.4,607.61855 7.3,2.2 -7.3,2.2 1.8,-2.2 -1.8,-2.2 z m -10.6,-6.6 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st30" + inkscape:label="LDH b" + inkscape:connector-curvature="0" + id="B_LDH" /><path + style="fill:none;stroke:#000000;stroke-width:1.82930005" + d="m 861.8,126.21855 0,-11.3 30,0 m -20.8,-8.8 c -1.7,5.6 4.7,8.7 4.7,8.7 m 3.2,-0.2 c 4.9,-1.1 3.2,-8.9 3.2,-8.9" + class="st109" + inkscape:label="PFKP_PFKL_PFKM_3" + inkscape:connector-curvature="0" + id="R_PFKP_PFKL_PFKM_3" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 888.2,116.91855 c 7.3,-2.2 7.3,-2.2 7.3,-2.2 l -7.3,-2.2 1.8,2.2 -1.8,2.2 z m -6.9,-9.3 c 1.5,-4.3 1.5,-4.3 1.5,-4.3 l 1.4,4.7 -1.4,-1.3 -1.5,0.9 z" + class="st30" + inkscape:label="PFKP_PFKL_PFKM_3 b" + inkscape:connector-curvature="0" + id="B_PFKP_PFKL_PFKM_3" /><path + style="fill:none;stroke:#000000;stroke-width:1.71169996" + d="m 859.5,122.51855 c 2.1,6.2 2.1,6.2 2.1,6.2 l 2.1,-6.2 -2.1,1.5 -2.1,-1.5 z m 9.8,-14.9 c 1.5,-4.3 1.5,-4.3 1.5,-4.3 l 1.4,4.7 -1.4,-1.3 -1.5,0.9 z" + class="st152" + inkscape:label="PFKP_PFKL_PFKM_3 f" + inkscape:connector-curvature="0" + id="F_PFKP_PFKL_PFKM_3" /><path + style="fill:none;stroke:#000000;stroke-width:1.74290001" + d="m 491.3,814.71855 61.5,3.7 m 11.8,25.5 c -4.4,0.5 -8.8,-1.3 -11.3,-4.5 -2.5,-3.3 -2.7,-7.5 -0.6,-10.8 2.2,-3.4 6.4,-5.3 10.8,-5.1 m -9.8,29.2 c -3.7,-13.4 -3.5,-27.4 0.7,-40.9" + class="st153" + inkscape:label="CS" + inkscape:connector-curvature="0" + id="R_CS" /><path + style="fill:none;stroke:#000000;stroke-width:1.63900006" + d="m 662.5,768.41855 c 2.1,4.7 2.1,4.7 2.1,4.7 l 1,-5.3 -1.4,1.6 -1.7,-1 z m 37.5,-1.5 c 2.1,4.7 2.1,4.7 2.1,4.7 l 1,-5.3 -1.4,1.6 -1.7,-1 z m 9.6,-14.8 c 6.3,-1.4 6.3,-1.4 6.3,-1.4 l -4.4,4.1 0.4,-2 -2.3,-0.7 z m -26.1,17.8 c 2.1,4.7 2.1,4.7 2.1,4.7 l 1,-5.3 -1.4,1.6 -1.7,-1 z" + class="st154" + inkscape:label="IDH3 f" + inkscape:connector-curvature="0" + id="F_IDH3" /><path + style="fill:none;stroke:#000000;stroke-width:1.81630003" + d="m 640,727.51855 c -3.8,-4 -3.8,-4 -3.8,-4 l 1.6,6.8 0.4,-2.8 1.8,0 z m -6.5,12.6 c -6.3,1.4 -6.3,1.4 -6.3,1.4 l 4.4,-4.1 -0.4,2 2.3,0.7 z" + class="st134" + inkscape:label="IDH2 b" + inkscape:connector-curvature="0" + id="B_IDH2" /><path + style="fill:none;stroke:#000000;stroke-width:1.63900006" + d="m 661.1,725.61855 c 2.1,-4.7 2.1,-4.7 2.1,-4.7 l 1,5.3 -1.4,-1.6 -1.7,1 z m 38.1,1.5 c 2.1,-4.7 2.1,-4.7 2.1,-4.7 l 1,5.3 -1.4,-1.6 -1.7,1 z m -15.7,-3 c 2.1,-4.7 2.1,-4.7 2.1,-4.7 l 1,5.3 -1.4,-1.6 -1.7,1 z m 26.1,17.3 c 6.3,1.4 6.3,1.4 6.3,1.4 l -4.4,-4.1 0.4,2 -2.3,0.7 z" + class="st154" + inkscape:connector-curvature="0" + id="path2385" /><path + style="fill:none;stroke:#000000;stroke-width:1.81599998" + d="m 775.5,787.91855 c 4.5,4.3 4.5,4.3 4.5,4.3 l -1.5,-6.1 -0.8,2.2 -2.2,-0.4 z m 7.8,-13.5 c 3.8,-1 3.8,-1 3.8,-1 l -2.8,3.2 0.3,-1.7 -1.3,-0.5 z" + class="st55" + inkscape:label="DLSTP1_DLD_OGDH_PDHX_DLST_DHTKD1_OGDHL f" + inkscape:connector-curvature="0" + id="F_DLSTP1_DLD_OGDH_PDHX_DLST_DHTKD1_OGDHL" /><path + style="fill:none;stroke:#000000;stroke-width:1.81599998" + d="m 551.9,886.51855 c -4,4 -4,4 -4,4 l 5.5,-0.9 -1.9,-1 0.4,-2.1 z m 9.4,-8.4 c -4.3,-4.3 -4.3,-4.3 -4.3,-4.3 l 1.3,6 0.8,-2.1 2.2,0.4 z" + class="st55" + inkscape:label="MDH2 f" + inkscape:connector-curvature="0" + id="F_MDH2" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 572.4,693.91855 c 4.9,2 4.9,2 4.9,2 l -5.6,1.3 1.7,-1.6 -1,-1.7 z m -10.5,-159.2 c -2.3,-6.3 -2.3,-6.3 -2.3,-6.3 l -1.6,6.5 1.9,-1.7 2,1.5 z" + class="st30" + inkscape:label="SLC25A1 f" + inkscape:connector-curvature="0" + id="F_SLC25A1" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 561.5,781.41855 c -2.3,6.3 -2.3,6.3 -2.3,6.3 l -1.6,-6.5 1.9,1.7 2,-1.5 z m -16.4,-117.8 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z" + class="st73" + inkscape:label="SLC25A1 b" + inkscape:connector-curvature="0" + id="B_SLC25A1" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 639.9,566.81855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -20.1,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -16.2,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 50.9,14.5 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" + class="st22" + inkscape:label="IDH1 f" + inkscape:connector-curvature="0" + id="F_IDH1" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 637.5,509.41855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -16.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -20.1,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 51.9,11.5 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" + class="st22" + inkscape:label="ACLY f" + inkscape:connector-curvature="0" + id="F_ACLY" /><path + style="fill:none;stroke:#000000;stroke-width:2.41549993" + d="m 1094.7,430.01855 -120.1,-0.2 m 106.7,0.4 c -6,1.3 -5.5,10.6 -5.5,10.6 m -88,-10.9 c -6,1.3 -5.5,10.6 -5.5,10.6 m 48,-10.5 c -6,1.3 -5.5,10.6 -5.5,10.6 m 3.2,-10.2 c 5.9,-1.3 4.4,-11.9 4.4,-11.9 m 46.7,11.9 c 5.9,-1.3 4.4,-11.9 4.4,-11.9 m -93.9,11.4 c 5.9,-1.3 4.4,-11.9 4.4,-11.9 m 58.8,11.9 c 5.9,-1.3 4.4,-11.9 4.4,-11.9" + class="st155" + inkscape:label="OLAH_FASN " + inkscape:connector-curvature="0" + id="R_OLAH_FASN" /><text + style="font-size:10px;font-family:Calibri" + id="text1667" + class="st17 st18" + x="722.22681" + y="501.87915">CoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.96720004" + d="m 740.8,519.01855 -25,-0.5 m 12.1,-0.2 c -5.9,1.2 -4.4,11.4 -4.4,11.4 m 1.3,-10.6 c 5.9,-1.4 5.4,-11.9 5.4,-11.9" + class="st156" + inkscape:label="ACAT1_ACAT2" + inkscape:connector-curvature="0" + id="R_ACAT1_ACAT2" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 728.4,509.41855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 11.1,11.6 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z" + class="st30" + inkscape:label="ACAT1_ACAT2 f" + inkscape:connector-curvature="0" + id="F_ACAT1_ACAT2" /><text + style="font-size:10px;font-family:Calibri" + id="text1671" + class="st17 st18" + x="710.4895" + y="542.85089">AcCoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.22309995" + d="m 716.3,520.51855 c -6.4,-2.1 -6.4,-2.1 -6.4,-2.1 l 6.5,-1.8 -1.7,1.9 1.6,2 z m 5.8,7.9 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" + class="st157" + inkscape:label="ACAT1_ACAT2 B" + inkscape:connector-curvature="0" + id="B_ACAT1_ACAT2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1674" + class="st15 st16" + x="749.35974" + y="522.77277">AcAcCoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.83369994" + d="m 841.4,518.71855 c -5.9,1 -4.4,9.5 -4.4,9.5 m -18.1,-9.5 c -5.9,1 -4.4,9.5 -4.4,9.5 m 7.6,-9.6 c 5.9,-1.2 4.4,-11.4 4.4,-11.4 m 21.3,11.7 -37.5,-0.4" + class="st158" + inkscape:label="HMGCS1_HMGCS2 " + inkscape:connector-curvature="0" + id="R_HMGCS1_HMGCS2" /><text + style="font-size:10px;font-family:Calibri" + id="text1677" + class="st17 st18" + x="828.9563" + y="536.06281">H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1679" + class="st17 st26" + x="835.18683" + y="538.06281">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1681" + class="st17 st18" + x="838.2757" + y="536.06281">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1683" + class="st17 st18" + x="798.9895" + y="535.35089">AcCoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1685" + class="st17 st18" + x="818.22681" + y="501.87915">CoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.22309995" + d="m 846,521.01855 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z m -21,-11.6 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st157" + inkscape:label="HMGCS1_HMGCS2 f" + inkscape:connector-curvature="0" + id="F_HMGCS1_HMGCS2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1688" + class="st15 st16" + x="855.85974" + y="522.77277">HMGCoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.22309995" + d="m 1035.4,520.81855 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z m -102.4,-11.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 25.9,0.4 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 33,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 18,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 16.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st157" + inkscape:label="MVD f" + inkscape:connector-curvature="0" + id="F_MVD" /><path + style="fill:none;stroke:#000000;stroke-width:1.85309994" + d="m 1269.2,518.61855 c 5.9,-1.2 5.4,-10.1 5.4,-10.1 m -24.9,10.1 c 5.9,-1.2 5.4,-10.1 5.4,-10.1 m -27.9,10.1 c 5.9,-1.2 5.4,-10.1 5.4,-10.1 m -51.9,10.1 c 5.9,-1.2 5.4,-10.1 5.4,-10.1 m 57.3,10.3 c -5.9,1 -4.4,9.6 -4.4,9.6 m -15.8,-9.6 c -5.9,1 -4.4,9.6 -4.4,9.6 m -36.9,-10.1 c -5.9,1 -4.4,9.6 -4.4,9.6 m 105.2,-9.1 -133.5,-0.2 m 9.1,-0.1 c -5.9,1 -4.4,9.6 -4.4,9.6 m 4.3,-9.5 c 5.9,-1.2 5.4,-10.1 5.4,-10.1" + class="st159" + inkscape:label="DHCR24_LEFTY1" + inkscape:connector-curvature="0" + id="R_DHCR24_LEFTY1" /><path + style="fill:none;stroke:#000000;stroke-width:2.22309995" + d="m 1113.4,520.51855 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z m -11.1,-10.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st157" + inkscape:label="ARID4B_GGPS1_FDPS_FDPSP7_2 f" + inkscape:connector-curvature="0" + id="F_ARID4B_GGPS1_FDPS_FDPSP7_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.22309995" + d="m 1281,520.71855 c 6.4,-2.1 6.4,-2.1 6.4,-2.1 l -6.5,-1.8 1.7,1.9 -1.6,2 z m -7.8,-11.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -19.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -22.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -46.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -22.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st157" + inkscape:label="DHCR24_LEFTY1 f" + inkscape:connector-curvature="0" + id="F_DHCR24_LEFTY1" /><path + style="fill:none;stroke:#000000;stroke-width:2.22309995" + d="m 768.2,457.11855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -35,0.2 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 45.6,8.8 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" + class="st157" + inkscape:label="ACACB_PRKAG2_PRKAB2_ACACA_PRKAA2 f" + inkscape:connector-curvature="0" + id="F_ACACB_PRKAG2_PRKAB2_ACACA_PRKAA2" /><path + style="fill:none;stroke:#000000;stroke-width:2.22309995" + d="m 779,432.11855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -16,-11.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st157" + inkscape:label="FASN_1 f" + inkscape:connector-curvature="0" + id="F_FASN_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 864.2,457.11855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 11.6,9.6 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" + class="st22" + inkscape:connector-curvature="0" + id="F_MCAT_FASN" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1093.3,432.21855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -11.1,-11.5 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -51.2,-1.1 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 25,0.2 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -63.6,1.2 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st22" + inkscape:label="OLAH_FASN f" + inkscape:connector-curvature="0" + id="F_OLAH_FASN" /><path + style="fill:none;stroke:#000000;stroke-width:2.2256" + d="m 975.2,225.31855 c -6,1.1 -5.5,9 -5.5,9 m -30.5,-9 c -6,1.1 -5.5,9 -5.5,9 m -50,-9 c -6,1.1 -5.5,9 -5.5,9 m -39.5,-9 c -6,1.1 -5.5,9 -5.5,9 m 98.6,-9.1 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m -71.9,10.2 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m 16.6,10.2 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m -67.6,10.2 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m 85.1,10.6 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m -73.5,9.4 c 6,-1 4.5,-9.4 4.5,-9.4 m 15.7,9.9 c -6,1.1 -5.5,9 -5.5,9 m -37,-9.1 c -6,1.1 -5.5,9 -5.5,9 m 99.1,-8.8 c -6,1.1 -5.5,9 -5.5,9 m 73.4,-9.2 -174.7,-0.1" + class="st160" + inkscape:label="ATIC_2" + inkscape:connector-curvature="0" + id="R_ATIC_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 981.4,227.31855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -46.6,-11.1 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -20.2,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -26.4,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -21,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -21.8,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -20.2,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st22" + inkscape:label="ATIC_2 f" + inkscape:connector-curvature="0" + id="F_ATIC_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.06660008" + d="m 926.5,278.81855 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -22.6,8.2 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -25.6,8.2 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -28.6,8.5 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -27.1,8.5 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m 56.9,8.8 c -6,1.1 -5.5,9.2 -5.5,9.2 m -12.5,-9.2 c -6,1.1 -5.5,9.2 -5.5,9.2 m -14,-9.7 c -6,1.1 -5.5,9.2 -5.5,9.2 m -15.5,-9.2 c -6,1.1 -5.5,9.2 -5.5,9.2 m -11,-9.5 c -6,1.1 -5.5,9.2 -5.5,9.2 m -31.5,-9.3 148.9,1.2 m -134.4,-1.1 c -6,1.1 -5.5,9.2 -5.5,9.2 m 2.5,-8.7 c 6.1,-0.9 4.6,-8.5 4.6,-8.5 m -16.1,-40.9 c 0,49.6 0,49.6 0,49.6" + class="st161" + inkscape:label="UMPS_2" + inkscape:connector-curvature="0" + id="R_UMPS_2" /><path + style="fill:none;stroke:#000000;stroke-width:1.7335" + d="m 1087.7,225.31855 -51.1,-0.3 m 13,0 c -6,0.8 -5.5,6.9 -5.5,6.9 m 12.9,-7.1 c 6,-1 4.5,-9.4 4.5,-9.4 m -18.9,9.8 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m 27.3,10.2 c 5.9,-1.1 4.4,-10.2 4.4,-10.2 m -10.4,10 c -6,0.8 -5.5,6.9 -5.5,6.9" + class="st162" + inkscape:connector-curvature="0" + id="R_TNRC6B_ADSL_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1086.5,227.21855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -9.3,-11 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -17.3,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -14.2,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st22" + inkscape:connector-curvature="0" + id="F_TNRC6B_ADSL_1" /><text + style="font-size:10px;font-family:Calibri" + id="text1703" + class="st17 st18" + x="1059.1674" + y="207.14964">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1256.9,272.21855 c 6.9,-2 6.9,-2 6.9,-2 l -6.8,-2.4 1.7,2.2 -1.8,2.2 z m -8.6,7.4 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" + class="st32" + inkscape:label="GUK1_1 f" + inkscape:connector-curvature="0" + id="F_GUK1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1234.2,272.11855 c -6.9,-2 -6.9,-2 -6.9,-2 l 6.8,-2.4 -1.7,2.2 1.8,2.2 z m 3.6,7.4 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" + class="st32" + inkscape:label="GUK1_1 b" + inkscape:connector-curvature="0" + id="B_GUK1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1321.7,270.71855 c 6.9,-2 6.9,-2 6.9,-2 l -6.8,-2.4 1.7,2.2 -1.8,2.2 z m -7.7,8.8 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" + class="st32" + inkscape:label="RRM2B_TXN_RRM1_RRM2B_1 f" + inkscape:connector-curvature="0" + id="F_RRM2B_TXN_RRM1_RRM2B_1" /><text + style="font-size:10px;font-family:Calibri" + id="text1708" + class="st17 st18" + x="1379.2269" + y="295.87714">ADP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1710" + class="st17 st18" + x="1397.4281" + y="296.41336">ATP</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.92519999" + d="m 1410.2,269.91855 c -24.9,0 -24.9,0 -24.9,0 m 16.5,9.5 c 2.4,-5.9 -3.6,-9.5 -3.6,-9.5 m -2.6,0.1 c -5,0.9 -4.4,9.3 -4.4,9.3" + class="st148" + inkscape:label="GUK1_2" + inkscape:connector-curvature="0" + id="R_GUK1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1409.9,272.31855 c 6.9,-2 6.9,-2 6.9,-2 l -6.8,-2.4 1.7,2.2 -1.8,2.2 z m -8.5,7.4 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" + class="st32" + inkscape:label="GUK1_2 f" + inkscape:connector-curvature="0" + id="F_GUK1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1386,271.61855 c -6.9,-2 -6.9,-2 -6.9,-2 l 6.8,-2.4 -1.7,2.2 1.8,2.2 z m 3.5,7.4 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" + class="st32" + inkscape:label="GUK1_2 b" + inkscape:connector-curvature="0" + id="B_GUK1_2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1715" + class="st15 st16" + x="1420.6156" + y="273.48557">dGMP</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.68470001" + d="m 1156.6,213.31855 c -2.4,6.7 3.6,10.9 3.6,10.9 m 15.7,0.2 c -26.9,0 -26.9,0 -26.9,0 m 19.4,-11.1 c 2.4,6.7 -3.6,10.9 -3.6,10.9" + class="st163" + inkscape:label="AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1" + inkscape:connector-curvature="0" + id="R_AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1152.2,221.91855 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z m 1.9,-8.8 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st32" + inkscape:label="AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1 f" + inkscape:connector-curvature="0" + id="F_AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1175.9,222.21855 c 6.9,2 6.9,2 6.9,2 l -6.8,2.4 1.7,-2.2 -1.8,-2.2 z m -8.6,-9.1 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st32" + inkscape:label="AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1 b" + inkscape:connector-curvature="0" + id="B_AK2_TAF9_AK1_AK7_AK3_AK5_AKD1_AK4_AK8_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1238.3,226.01855 c 6.9,-2 6.9,-2 6.9,-2 l -6.8,-2.4 1.7,2.2 -1.8,2.2 z m -8.5,8.6 c 2,4.9 2,4.9 2,4.9 l 1.3,-5.6 -1.6,1.7 -1.7,-1 z" + class="st32" + inkscape:label="RRM2B_TXN_RRM1_RRM2B_2 f" + inkscape:connector-curvature="0" + id="F_RRM2B_TXN_RRM1_RRM2B_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 937.8,280.91855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -8.4,-10.3 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -18,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -21,-0.9 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -24,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -22.5,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m -39,0 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st22" + inkscape:label="UMPS_2 F" + inkscape:connector-curvature="0" + id="F_UMPS_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.48839998" + d="m 965.8,316.01855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2,-7.4 -2.1,1.9 -2.1,-1.8 z m 12.7,-5.1 c 4.3,-1.4 4.3,-1.4 4.3,-1.4 l -4.4,-1 1.1,1.1 -1,1.3 z" + class="st164" + inkscape:label="CMPK2_CMPK1_1 f" + inkscape:connector-curvature="0" + id="F_CMPK2_CMPK1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.48839998" + d="m 970,295.11855 c -2.2,-7.3 -2.2,-7.3 -2.2,-7.3 l -2,7.4 2.1,-1.9 2.1,1.8 z m 8.5,4.8 c 4.3,-1.4 4.3,-1.4 4.3,-1.4 l -4.4,-1 1.1,1.1 -1,1.3 z" + class="st164" + inkscape:label="CMPK2_CMPK1_1 b" + inkscape:connector-curvature="0" + id="B_CMPK2_CMPK1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.31130004" + d="m 933.3,323.31855 c -1.9,-4.3 -1.9,-4.3 -1.9,-4.3 l -1.4,4.4 1.6,-1.2 1.7,1.1 z m -11,11.6 c -7.2,-2.4 -7.2,-2.4 -7.2,-2.4 l 7.4,-1.9 -1.9,2.1 1.7,2.2 z" + class="st165" + inkscape:label="RRM2B_TXN_RRM1_RRM2_1 f" + inkscape:connector-curvature="0" + id="F_RRM2B_TXN_RRM1_RRM2_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.31130004" + d="m 836,334.81855 c -7.2,-2.4 -7.2,-2.4 -7.2,-2.4 l 7.4,-1.9 -1.9,2.1 1.7,2.2 z m 8.7,-11.2 c -1.9,-4.3 -1.9,-4.3 -1.9,-4.3 l -1.4,4.4 1.6,-1.2 1.7,1.1 z" + class="st165" + inkscape:label="CMPK1_DTYMK f" + inkscape:connector-curvature="0" + id="F_CMPK1_DTYMK" /><path + style="fill:none;stroke:#000000;stroke-width:2.31130004" + d="m 859.9,334.81855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z m -6.8,-10.8 c 1.9,-4.3 1.9,-4.3 1.9,-4.3 l 1.4,4.4 -1.6,-1.2 -1.7,1.1 z" + class="st165" + inkscape:label="CMPK1_DTYMK b" + inkscape:connector-curvature="0" + id="B_CMPK1_DTYMK" /><path + style="fill:none;stroke:#000000;stroke-width:2.31130004" + d="m 731.1,335.41855 c -7.2,-2.4 -7.2,-2.4 -7.2,-2.4 l 7.4,-1.9 -1.9,2.1 1.7,2.2 z m 9.1,-12.4 c -1.7,-4.7 -1.7,-4.7 -1.7,-4.7 l -1.1,4.8 1.3,-1.3 1.5,1.2 z" + class="st165" + inkscape:label="TYMS " + inkscape:connector-curvature="0" + id="F_TYMS" /><path + style="fill:none;stroke:#000000;stroke-width:2.31130004" + d="m 770.6,330.81855 c 7.2,2.4 7.2,2.4 7.2,2.4 l -7.4,1.9 1.9,-2.1 -1.7,-2.2 z m -4.7,-8.4 c -1.9,-5.3 -1.9,-5.3 -1.9,-5.3 l -1.8,5.3 1.8,-1.3 1.9,1.3 z" + class="st165" + inkscape:label="TYMS b" + inkscape:connector-curvature="0" + id="B_TYMS" /><path + style="fill:none;stroke:#000000;stroke-width:1.82930005" + d="m 995.7,334.41855 c -7.4,-1.9 -7.4,-1.9 -7.4,-1.9 l 7.2,-2.4 -1.8,2.2 2,2.1 z m 3.8,6 c 1.6,4.7 1.6,4.7 1.6,4.7 l 2.4,-4.6 -2.1,1.1 -1.9,-1.2 z" + class="st109" + inkscape:label="NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3 f" + inkscape:connector-curvature="0" + id="F_NME2_NME3_NME4_NME5_NME2P1_NME7_NME6_NME1_NME2_3" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1093.9,325.01855 c -1.6,-6.1 -1.6,-6.1 -1.6,-6.1 l -1.3,6.2 1.4,-1.6 1.5,1.5 z m 9.7,9.9 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" + class="st73" + inkscape:label="CTPS2_GATM_CTPS1 f" + inkscape:connector-curvature="0" + id="F_CTPS2_GATM_CTPS1" /><text + style="font-size:10px;font-family:Calibri" + id="text1731" + class="st17 st18" + x="1236.1302" + y="316.99045">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1733" + class="st17 st18" + x="1216.7562" + y="317.36545">ADP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1229.5,324.71855 c -1.6,-6.1 -1.6,-6.1 -1.6,-6.1 l -1.3,6.2 1.4,-1.6 1.5,1.5 z m -7,5.6 c -7.4,1.9 -7.4,1.9 -7.4,1.9 l 7.2,2.4 -1.8,-2.2 2,-2.1 z" + class="st73" + inkscape:label="CMPK2_CMPK1_2 b" + inkscape:connector-curvature="0" + id="B_CMPK2_CMPK1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1246.1,335.71855 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z m -3.6,-10.9 c -1.1,-5.1 -1.1,-5.1 -1.1,-5.1 l -1.7,5 1.5,-1.2 1.3,1.3 z" + class="st22" + inkscape:label="CMPK2_CMPK1_2 f" + inkscape:connector-curvature="0" + id="F_CMPK2_CMPK1_2" /><path + style="fill:none;stroke:#000000;stroke-width:1.82930005" + d="m 1218.5,332.61855 28.3,0.4 m -18.4,-9.2 c -2.2,5.6 3.9,8.9 3.9,8.9 m 4.8,0 c 5,-0.9 4,-8.9 4,-8.9" + class="st109" + inkscape:label="CMPK2_CMPK1_2" + inkscape:connector-curvature="0" + id="R_CMPK2_CMPK1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.31130004" + d="m 1196.6,360.01855 c 2.4,7.2 2.4,7.2 2.4,7.2 l 1.9,-7.4 -2.1,1.9 -2.2,-1.7 z m -6.1,-7.6 c -4.6,1 -4.6,1 -4.6,1 l 2.7,-3.7 0,1.9 1.9,0.8 z" + class="st165" + inkscape:connector-curvature="0" + id="F_RRM2B_TXN_RRM1_RRM2_2" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1739" + class="st15 st16" + x="1258.7123" + y="382.35764">dCMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1741" + class="st17 st18" + x="1236.1302" + y="361.80984">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1743" + class="st17 st18" + x="1216.7562" + y="362.36545">ADP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1229.5,369.71855 c -1.6,-6.1 -1.6,-6.1 -1.6,-6.1 l -1.3,6.2 1.4,-1.6 1.5,1.5 z m -7,5.6 c -7.4,1.9 -7.4,1.9 -7.4,1.9 l 7.2,2.4 -1.8,-2.2 2,-2.1 z" + class="st73" + inkscape:label="CMPK2_CMPK1_3 b" + inkscape:connector-curvature="0" + id="B_CMPK2_CMPK1_3" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1246.1,380.71855 c 7.2,-2.5 7.2,-2.5 7.2,-2.5 l -7.4,-1.8 1.9,2.1 -1.7,2.2 z m -3.6,-10.9 c -1.1,-5.1 -1.1,-5.1 -1.1,-5.1 l -1.7,5 1.5,-1.2 1.3,1.3 z" + class="st22" + inkscape:label="CMPK2_CMPK1_3 f" + inkscape:connector-curvature="0" + id="F_CMPK2_CMPK1_3" /><path + style="fill:none;stroke:#000000;stroke-width:1.82930005" + d="m 1218.5,377.61855 28.3,0.4 m -18.4,-9.2 c -2.2,5.6 3.9,8.9 3.9,8.9 m 4.8,0 c 5,-0.9 4,-8.9 4,-8.9" + class="st109" + inkscape:label="CMPK2_CMPK1_3" + inkscape:connector-curvature="0" + id="R_CMPK2_CMPK1_3" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 236.8,382.21855 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z m -52.2,-23.9 c -6.2,2.5 -6.2,2.5 -6.2,2.5 l 6.5,1.5 -1.7,-1.8 1.4,-2.2 z" + class="st73" + inkscape:label="MTHFD1_3 f" + inkscape:connector-curvature="0" + id="F_MTHFD1_3" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 206.6,426.41855 c -6.2,2.5 -6.2,2.5 -6.2,2.5 l 6.5,1.5 -1.7,-1.8 1.4,-2.2 z m 31.7,-24 c 7,-1.3 7,-1.3 7,-1.3 l -6.9,-1.9 1.7,1.7 -1.8,1.5 z" + class="st73" + inkscape:label="MTHFD1_3 b" + inkscape:connector-curvature="0" + id="B_MTHFD1_3" /><text + style="font-size:9.99962234px;font-family:Calibri" + id="text1750" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="301.1604" + y="383.42343">H</text> +<text + style="font-size:6.09346962px;font-family:Calibri" + id="text1752" + class="st17 st26" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="307.39139" + y="385.42346">2</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text1754" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="310.4798" + y="383.42337">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 290,301.91855 c 1.6,-5.3 17.5,-4.5 17.5,-4.5 m -2.3,19.7 c -9.8,2.5 -15.9,-3.8 -15.9,-3.8 m -0.3,11.1 0.2,-34.2" + class="st79" + inkscape:label="MTHFD2_2" + inkscape:connector-curvature="0" + id="R_MTHFD2_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 287,292.01855 c 2.3,-6.3 2.3,-6.3 2.3,-6.3 l 1.6,6.5 -1.9,-1.7 -2,1.5 z m 15.6,3.3 c 7,1.6 7,1.6 7,1.6 l -6.9,1.6 1.7,-1.6 -1.8,-1.6 z" + class="st73" + inkscape:label="MTHFD2_2 f" + inkscape:connector-curvature="0" + id="F_MTHFD2_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 301.3,316.11855 c 7,1.6 7,1.6 7,1.6 l -6.9,1.6 1.7,-1.6 -1.8,-1.6 z m -10.5,6.6 c -2,7.3 -2,7.3 -2,7.3 l -2.3,-7.3 2.2,1.8 2.1,-1.8 z" + class="st73" + inkscape:label="MTHFD2_2 b" + inkscape:connector-curvature="0" + id="B_MTHFD2_2" /><text + style="font-size:10px;font-family:Calibri" + id="text1759" + class="st17 st18" + transform="matrix(0.99999044,0.00437222,-0.00437222,0.99999044,0,0)" + x="311.63144" + y="319.94809">NADH</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text1761" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="307.66241" + y="303.30228">NAD</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 402.2,547.01855 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z m 34,12.7 c 6.3,-2.3 6.3,-2.3 6.3,-2.3 l -6.5,-1.6 1.7,1.9 -1.5,2 z" + class="st30" + inkscape:label="PEPCK f" + inkscape:connector-curvature="0" + id="F_PEPCK" /><path + style="fill:none;stroke:#000000;stroke-width:2.82299995" + d="m 268.8,649.41855 c 2.3,7.2 2.3,7.2 2.3,7.2 l 2,-7.3 -2.1,1.9 -2.2,-1.8 z m -11.1,-9.3 c -5.1,1.5 -5.1,1.5 -5.1,1.5 l 5.5,1.8 -1.5,-1.7 1.1,-1.6 z" + class="st45" + inkscape:label="FH_3 f" + inkscape:connector-curvature="0" + id="F_FH_3" /><path + style="fill:none;stroke:#000000;stroke-width:2.23090005" + d="m 1444.3,1060.1186 c 2.4,-5.7 2.4,-5.7 2.4,-5.7 l 2,5.8 -2.1,-1.5 -2.3,1.4 z m 57.4,10.4 c 6.6,3 6.6,3 6.6,3 l -7.1,1.4 2,-2 -1.5,-2.4 z" + class="st37" + inkscape:connector-curvature="0" + id="B_SLC25A5_SLC25A4_SLC25A6" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 1050.3,691.11855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z m 11.6,-3.8 c 4.7,1.4 4.7,1.4 4.7,1.4 l -5.1,1.5 1.4,-1.4 -1,-1.5 z" + class="st14" + inkscape:label="TransportGlu f" + inkscape:connector-curvature="0" + id="F_TransportGlu" /><path + style="fill:none;stroke:#000000;stroke-width:2.15549994" + d="m 954.1,690.71855 c 2.2,7.1 2.2,7.1 2.2,7.1 l 2.2,-7.1 -2.2,1.8 -2.2,-1.8 z m 12.5,-2.2 c 4.7,1.3 4.7,1.3 4.7,1.3 l -5.1,1.4 1.4,-1.4 -1,-1.3 z" + class="st166" + inkscape:label="TransportGln f" + inkscape:connector-curvature="0" + id="F_TransportGln" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 956,636.91855 c 2.2,7.3 2.2,7.3 2.2,7.3 l 2.2,-7.3 -2.2,1.8 -2.2,-1.8 z m 77.1,-13.1 c -1.4,4.7 -1.4,4.7 -1.4,4.7 l -1.5,-5.1 1.4,1.4 1.5,-1 z m -48,0.4 c -1.4,4.7 -1.4,4.7 -1.4,4.7 l -1.5,-5.1 1.4,1.4 1.5,-1 z" + class="st14" + inkscape:label="GS f" + inkscape:connector-curvature="0" + id="F_GS" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1022.5,652.11855 c 6.9,2.1 6.9,2.1 6.9,2.1 l -6.9,2.3 1.7,-2.2 -1.7,-2.2 z m -14.8,-6.7 c 1.4,-4.7 1.4,-4.7 1.4,-4.7 l 1.5,5.1 -1.4,-1.4 -1.5,1 z" + class="st32" + inkscape:label="GLS2 f" + inkscape:connector-curvature="0" + id="F_GLS2" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1029.4,709.51855 c 6.9,-2.1 6.9,-2.1 6.9,-2.1 l -6.9,-2.3 1.7,2.2 -1.7,2.2 z m -17.8,-8.9 c 0.9,-4.9 0.9,-4.9 0.9,-4.9 l -3.6,3.9 1.9,-0.6 0.8,1.6 z" + class="st32" + inkscape:label="GLS f" + inkscape:connector-curvature="0" + id="F_GLS" /><path + style="fill:none;stroke:#000000;stroke-width:1.99090004" + d="m 1270.4,787.81855 c 2.8,-7.3 -3.1,-12.1 -3.1,-12.1 m 49.7,12.1 c 2.8,-7.3 -3.1,-12.1 -3.1,-12.1 m -17.1,12.1 c 2.8,-7.3 -3.1,-12.1 -3.1,-12.1 m -53.7,0.4 c -5.3,0.6 -5,7.6 -5,7.6 m 89.5,-8 c -99.3,0 -99.3,0 -99.3,0 m 29.8,0.4 c -5.3,0.6 -5,7.6 -5,7.6" + class="st167" + inkscape:label="CPS1" + inkscape:connector-curvature="0" + id="R_CPS1" /><text + style="font-size:16.00031662px;font-family:Calibri-Bold" + id="text1772" + class="st15 st16" + transform="matrix(0.99998015,0.00630041,-0.00630041,0.99998015,0,0)" + x="1205.1744" + y="771.00928">CP</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 1351.5,622.81855 c -6.9,-1.7 -6.9,-1.7 -6.9,-1.7 l 5.5,4.6 -0.8,-2.2 2.2,-0.7 z m 11,-3.3 c -1.8,-7.4 -1.8,-7.4 -1.8,-7.4 l -2.5,7.2 2.2,-1.7 2.1,1.9 z" + class="st73" + inkscape:label="ALDH4A1_2 f" + inkscape:connector-curvature="0" + id="F_ALDH4A1_2" /><text + style="font-size:9.99962234px;font-family:Calibri" + id="text1775" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1386.1115" + y="542.35461">Gly</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text1777" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="1404.1106" + y="542.55579">GA</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 952,862.81855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -12.1,9.3 c 1.3,7 1.3,7 1.3,7 l 1.9,-6.9 -1.7,1.7 -1.5,-1.8 z" + class="st22" + inkscape:label="CA5B_CA5A f" + inkscape:connector-curvature="0" + id="F_CA5B_CA5A" /><text + style="font-size:9.99962234px;font-family:Calibri" + id="text1780" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="665.34772" + y="1031.6384">H</text> +<text + style="font-size:6.09346962px;font-family:Calibri" + id="text1782" + class="st17 st26" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="671.57819" + y="1033.6384">2</text> +<text + style="font-size:9.99962234px;font-family:Calibri" + id="text1784" + class="st17 st18" + transform="matrix(0.9999378,-0.011153,0.011153,0.9999378,0,0)" + x="674.66699" + y="1031.6384">O</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.29760003" + d="m 707.7,1012.8186 c 2.9,-9.7 -3.2,-16.00005 -3.2,-16.00005 m -47.9,0.2 61.6,-0.1 m -33,15.90005 c 2.9,-9.7 -3.2,-16.00005 -3.2,-16.00005 m -14.3,0.3 c -5.3,1.4 -5.1,17.30005 -5.1,17.30005" + class="st79" + inkscape:label="SHMT1_2 " + inkscape:connector-curvature="0" + id="R_SHMT1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.09949994" + d="m 707,1008.9186 c 1.3,7 1.3,7 1.3,7 l 1.9,-6.9 -1.7,1.7 -1.5,-1.8 z m 10.5,-9.70005 c 6.3,-2.3 6.3,-2.3 6.3,-2.3 l -6.5,-1.7 1.7,1.9 -1.5,2.1 z m -33,9.70005 c 1.3,7 1.3,7 1.3,7 l 1.9,-6.9 -1.7,1.7 -1.5,-1.8 z" + class="st73" + inkscape:label="SHMT1_2 f" + inkscape:connector-curvature="0" + id="F_SHMT1_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1442.5,809.71855 c -7.2,2.4 -7.2,2.4 -7.2,2.4 l 7.4,1.9 -1.9,-2.1 1.7,-2.2 z" + class="st22" + inkscape:label="TransportFolate f" + inkscape:connector-curvature="0" + id="path1985" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1489.5,814.81855 c 7.2,-2.4 7.2,-2.4 7.2,-2.4 l -7.4,-1.9 1.9,2.1 -1.7,2.2 z" + class="st22" + inkscape:label="SLC16A3_SLC16A1_SLC16A5_2 f" + inkscape:connector-curvature="0" + id="F_SLC16A3_SLC16A1_SLC16A5_2" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1490.3,756.31855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" + class="st22" + inkscape:transform-center-y="-3.0492074" + inkscape:transform-center-x="0.87100132" + inkscape:label="Transport_serine b" + inkscape:connector-curvature="0" + id="B_Transport_serine" /><text + style="font-size:10.00011921px;font-family:Calibri" + id="text1791" + class="st17 st18" + transform="matrix(0.99998813,0.00487302,-0.00487302,0.99998813,0,0)" + x="835.31476" + y="1042.428">formate+ATP</text> +<text + style="font-size:10.00011921px;font-family:Calibri" + id="text1793" + class="st17 st18" + transform="matrix(0.99998813,0.00487302,-0.00487302,0.99998813,0,0)" + x="891.94086" + y="1042.8938">ADP+Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.80649996" + d="m 1525.5,392.51855 c -5.4,-1.7 -4.9,-14 -4.9,-14 m 10.8,14.3 c 5.5,-1.1 4.1,-10.6 4.1,-10.6 m 9,10.6 -33.9,-0.3" + class="st116" + inkscape:label="LHPP_PPA2_PRUNE_EIF4A2_NAV2_PPA1_1" + inkscape:connector-curvature="0" + id="R_LHPP_PPA2_PRUNE_EIF4A2_NAV2_PPA1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1543.5,394.81855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -6.5,-11.3 c -1.7,-5.2 -1.7,-5.2 -1.7,-5.2 l -1.4,5.3 1.5,-1.4 1.6,1.3 z" + class="st22" + inkscape:label="LHPP_PPA2_PRUNE_EIF4A2_NAV2_PPA1_1 f" + inkscape:connector-curvature="0" + id="F_LHPP_PPA2_PRUNE_EIF4A2_NAV2_PPA1_1" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1543.5,348.31855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -6.5,-11.3 c -1.7,-5.2 -1.7,-5.2 -1.7,-5.2 l -1.4,5.3 1.5,-1.4 1.6,1.3 z" + class="st22" + inkscape:label="CA12_CA2_CA9_CA14_CA1_CA3_CA4_CA7_CA13 f" + inkscape:connector-curvature="0" + id="F_CA12_CA2_CA9_CA14_CA1_CA3_CA4_CA7_CA13" /><path + style="fill:none;stroke:#000000;stroke-width:9.22049999;stroke-linecap:round;stroke-linejoin:round;stroke-miterlimit:2" + inkscape:connector-curvature="0" + d="m 290.9,65.418554 1141.8,0 c 111.4,0 201.6,90.299996 201.6,201.599996 l 0,777.20005 c 0,111.4 -90.3,201.6 -201.6,201.6 l -1141.8,0 c -111.4,0 -201.6,-90.3 -201.6,-201.6 l 0,-777.10005 c 0,-111.4 90.3,-201.699996 201.6,-201.699996 z" + class="st168" + id="rect3173" /><text + style="font-size:10px;font-family:Calibri" + id="text1799" + class="st17 st18" + x="1582.0922" + y="894.75116">AMP+PPi</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1801" + class="st17 st18" + x="1583.309" + y="884.0647">ATP+CoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.92519999" + d="m 1565.4,888.01855 c 0.9,5 9.3,4.4 9.3,4.4 m 4.5,-10.4 c -8.6,-2.3 -13.9,3.4 -13.9,3.4 m -0.1,-11.9 c 0,24.9 0,24.9 0,24.9" + class="st148" + inkscape:label="palmitateActivation" + inkscape:connector-curvature="0" + id="R_palmitateActivation" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1567.3,897.51855 c -2,6.9 -2,6.9 -2,6.9 l -2.4,-6.8 2.2,1.7 2.2,-1.8 z m 7.4,-3.5 c 4.9,-2 4.9,-2 4.9,-2 l -5.6,-1.3 1.7,1.6 -1,1.7 z" + class="st32" + inkscape:label="palmitateActivation f" + inkscape:connector-curvature="0" + id="F_palmitateActivation" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1805" + class="st15 st16" + x="1547.4984" + y="863.4964">Palm</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1807" + class="st15 st16" + x="1537.4193" + y="918.66138">PalmCoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1809" + class="st17 st18" + x="1582.8129" + y="953.61157">CoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1811" + class="st17 st18" + x="1582.9476" + y="942.5647">carnitine</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.92519999" + d="m 1565.2,932.01855 c 0,24.9 0,24.9 0,24.9 m 9.6,-16.5 c -5.9,-2.4 -9.5,3.6 -9.5,3.6 m 0.1,2.5 c 0.9,5 9.3,4.4 9.3,4.4" + class="st148" + inkscape:label="carnitineAcylTransferaseI" + inkscape:connector-curvature="0" + id="R_carnitineAcylTransferaseI" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1567.3,933.41855 c -2,-6.9 -2,-6.9 -2,-6.9 l -2.4,6.8 2.2,-1.7 2.2,1.8 z m 7.4,8.6 c 4.9,-2 4.9,-2 4.9,-2 l -5.6,-1.3 1.7,1.6 -1,1.7 z" + class="st32" + inkscape:label="carnitineAcylTransferaseI b" + inkscape:connector-curvature="0" + id="B_carnitineAcylTransferaseI" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1567.3,956.01855 c -2,6.9 -2,6.9 -2,6.9 l -2.4,-6.8 2.2,1.7 2.2,-1.8 z m 7.4,-3.5 c 4.9,-2 4.9,-2 4.9,-2 l -5.6,-1.3 1.7,1.6 -1,1.7 z" + class="st32" + inkscape:label="carnitineAcylTransferaseI f" + inkscape:connector-curvature="0" + id="F_carnitineAcylTransferaseI" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1816" + class="st15 st16" + x="1509.2845" + y="977.52167">PalmCarnitine</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.56680012" + d="m 1477.7,972.41855 c 5.3,-1.5 4.6,-15.8 4.6,-15.8 m -29,0 c -2.5,10 3.7,16.2 3.7,16.2 m -18.4,0.1 c 58.9,0 58.9,0 58.9,0" + class="st169" + inkscape:label="translocase" + inkscape:connector-curvature="0" + id="R_translocase" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1483.8,956.91855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m -43.4,14 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z" + class="st32" + inkscape:label="translocase f" + inkscape:connector-curvature="0" + id="F_translocase" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1454.7,956.91855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 40.6,13.9 c 6.9,2 6.9,2 6.9,2 l -6.8,2.4 1.7,-2.2 -1.8,-2.2 z" + class="st32" + inkscape:connector-curvature="0" + id="path3243" /><text + style="font-size:10px;font-family:Calibri" + id="text1821" + class="st17 st18" + x="1476.4476" + y="948.5647">carnitine</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1823" + class="st17 st18" + x="1425.4476" + y="948.5647">carnitine</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1825" + class="st15 st16" + x="1333.4193" + y="977.16138">PalmCarnitine</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1315.8,962.01855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 3.6,7.4 c 6.9,2 6.9,2 6.9,2 l -6.8,2.4 1.7,-2.2 -1.8,-2.2 z" + class="st32" + inkscape:connector-curvature="0" + id="path3291" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1305.3,962.01855 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m -8.5,7.4 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z" + class="st32" + inkscape:label="carnitineAcylTransferaseII f" + inkscape:connector-curvature="0" + id="F_carnitineAcylTransferaseII" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1309.9,971.31855 c 5,-0.9 4.4,-9.3 4.4,-9.3 m -10.6,-0.1 c -2.4,5.9 3.6,9.5 3.6,9.5 m -12,0 c 24.9,0 24.9,0 24.9,0" + class="st32" + inkscape:label="carnitineAcylTransferaseII " + inkscape:connector-curvature="0" + id="R_carnitineAcylTransferaseII" /><text + style="font-size:10px;font-family:Calibri" + id="text1830" + class="st17 st18" + x="1311.5248" + y="953.61157">CoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1832" + class="st17 st18" + x="1271.8422" + y="952.50116">carnitine</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1834" + class="st15 st16" + x="1222.6273" + y="976.7356">PalmCoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1836" + class="st17 st18" + x="1206.2504" + y="990.83716">7 CoA</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1838" + class="st17 st18" + x="1171.7504" + y="990.83716">7 NAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1840" + class="st17 st18" + x="1141.7504" + y="990.83716">7 FAD</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1842" + class="st17 st18" + x="1110.2504" + y="990.83716">7 H</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1844" + class="st17 st26" + x="1123.809" + y="992.83716">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1846" + class="st17 st18" + x="1126.8978" + y="990.83716">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1848" + class="st17 st18" + x="1165.7504" + y="951.83716">7 NADH</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1850" + class="st17 st18" + x="1128.2504" + y="951.83716">7 FADH</text> +<text + style="font-size:6.09369993px;font-family:Calibri" + id="text1852" + class="st17 st26" + x="1157.7816" + y="953.83716">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1854" + class="st17 st18" + x="1105.7504" + y="951.83716">7 H</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.93280005" + d="m 1120.2,971.91855 c -5.6,-1.9 -4.1,-12.1 -4.1,-12.1 m 35.6,12.1 c -5.6,-1.9 -4.1,-12.1 -4.1,-12.1 m 35.6,12.1 c -5.6,-1.9 -4.1,-12.1 -4.1,-12.1 m -58.4,11.7 c 5.6,1.5 5.5,11.8 5.5,11.8 m 24.5,-11.8 c 5.6,1.5 5.5,11.8 5.5,11.8 m 29,-11.8 c 5.6,1.5 5.5,11.8 5.5,11.8 m 13.9,-12.1 c 5.6,1.5 5.5,11.8 5.5,11.8 m 10.1,-11.6 -112,0.1" + class="st170" + inkscape:label="betaOxidation " + inkscape:connector-curvature="0" + id="R_betaOxidation" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1109.3,969.41855 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z m 8.5,-8.8 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 31.5,0 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z m 31.5,0 c -2,-4.9 -2,-4.9 -2,-4.9 l -1.3,5.6 1.6,-1.7 1.7,1 z" + class="st32" + inkscape:label="betaOxidation f" + inkscape:connector-curvature="0" + id="F_betaOxidation" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1858" + class="st15 st16" + x="1042.6273" + y="976.7356">8 AcCoA</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1567.3,874.91855 c -2,-6.9 -2,-6.9 -2,-6.9 l -2.4,6.8 2.2,-1.7 2.2,1.8 z m 7.4,8.6 c 4.9,-2 4.9,-2 4.9,-2 l -5.6,-1.3 1.7,1.6 -1,1.7 z" + class="st32" + inkscape:label="palmitateActivation b" + inkscape:connector-curvature="0" + id="B_palmitateActivation" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1861" + class="st15 st16" + x="1486.4927" + y="427.78244">ATP</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1863" + class="st15 st16" + x="1554.2847" + y="427.81766">ADP</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.80649996" + d="m 1544.5,425.81855 -33.9,-0.3" + class="st116" + inkscape:label="ATPmaintenance " + inkscape:connector-curvature="0" + id="R_ATPmaintenance" /><path + style="fill:none;stroke:#000000;stroke-width:2.5" + d="m 1543.5,427.81855 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z" + class="st22" + inkscape:label="ATPmaintenancef" + inkscape:connector-curvature="0" + id="F_ATPmaintenance" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1867" + class="st15 st38" + x="259.638" + y="851.84009">Pi</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1869" + class="st15 st16" + x="278.91238" + y="912.47101">Orn</text> +<path + style="fill:none;stroke:#000000;stroke-width:3.19709992" + d="m 237.8,908.91855 c -6,-8.4 -6,-12.6 -6.6,-16.9 m 29,16.8 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 11.2,13.9 -60.2,-0.3" + class="st171" + inkscape:label="UniportOrnithine" + inkscape:connector-curvature="0" + id="R_UniportOrnithine" /><path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 267.4,895.31855 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -51.1,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 l 0,0 z" + class="st140" + inkscape:label="UniportOrnithine f" + inkscape:connector-curvature="0" + id="F_UniportOrnithine" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1873" + class="st15 st38" + x="261.46759" + y="887.15851">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1875" + class="st15 st38" + x="226.01099" + y="888.6438">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1877" + class="st15 st16" + x="180.79909" + y="912.72589">Orn</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1879" + class="st15 st16" + x="303.034" + y="950.73657">Orn</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1881" + class="st15 st16" + x="170.7791" + y="950.48169">Orn</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 283.9,934.31855 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -50,2.4 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m -26.6,8.8 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z" + class="st140" + inkscape:connector-curvature="0" + id="path3519" /><path + style="fill:none;stroke:#000000;stroke-width:2.82299995" + d="m 218.4,948.01855 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7 m 65.1,12.5 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -43.2,14.1 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7 m 29.1,12.5 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 26.7,13.9 -84.7,-0.2" + class="st45" + inkscape:label="CotraspArgOrnA" + inkscape:connector-curvature="0" + id="R_CotraspArgOrnA" /><path + style="fill:none;stroke:#000000;stroke-width:2.35560012" + d="m 214.4,936.71855 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m 76.1,13.1 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -23.1,-15.5 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" + class="st46" + inkscape:label="CotraspArgOrnA f" + inkscape:connector-curvature="0" + id="F_CotraspArgOrnA" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1886" + class="st15 st38" + x="259.9368" + y="926.9231">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1888" + class="st15 st38" + x="226.01099" + y="927.6438">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1890" + class="st15 st38" + x="199.5208" + y="926.62427">Arg</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1892" + class="st15 st38" + x="273.05161" + y="926.62427">Arg</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1894" + class="st15 st16" + x="300.10669" + y="992.00116">Orn</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1896" + class="st15 st16" + x="176.7791" + y="991.49146">Orn</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 289.9,974.81855 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -76.6,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z m 60.1,-11.2 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" + class="st140" + inkscape:label="CotraspArgOrnB f" + inkscape:connector-curvature="0" + id="F_CotraspArgOrnB" /><path + style="fill:none;stroke:#000000;stroke-width:3.13730001" + d="m 227.1,988.41855 c -5.9,-8.2 -5.9,-12.4 -6.5,-16.5 m 62.1,16.4 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -41.5,14 c -5.9,-8.2 -5.9,-12.4 -6.5,-16.5 m 27.1,16.4 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 26.7,13.9 -84.7,-0.2" + class="st172" + inkscape:label="CotraspArgOrnB" + inkscape:connector-curvature="0" + id="R_CotraspArgOrnB" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1900" + class="st15 st38" + x="265.9368" + y="967.4231">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1902" + class="st15 st38" + x="232.01099" + y="968.1438">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1904" + class="st15 st38" + x="205.5208" + y="967.12427">Arg</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1906" + class="st15 st38" + x="279.05161" + y="967.12427">Arg</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1908" + class="st15 st16" + x="303.034" + y="1030.2366">Ci</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1910" + class="st15 st16" + x="182.74879" + y="1032.5325">Ci</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 283.9,1013.8186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -50,2.4 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m -26.6,8.8 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z" + class="st140" + inkscape:label="CotraspArgCitrA b" + inkscape:connector-curvature="0" + id="B_CotraspArgCitrA" /><path + style="fill:none;stroke:#000000;stroke-width:2.82299995" + d="m 218.4,1027.5186 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7 m 65.1,12.5 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -43.2,14.1 c -6.2,-6.3 -6.2,-9.5 -6.8,-12.7 m 29.1,12.5 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 26.7,13.9 -84.7,-0.2" + class="st45" + inkscape:label="CotraspArgCitrA" + inkscape:connector-curvature="0" + id="R_CotraspArgCitrA" /><path + style="fill:none;stroke:#000000;stroke-width:2.35560012" + d="m 214.4,1016.2186 c -2.4,-5.9 -2.4,-5.9 -2.4,-5.9 l -2.3,6 2.3,-1.5 2.4,1.4 z m 76.1,13.1 c 7.2,-2.3 7.2,-2.3 7.2,-2.3 l -7.3,-2 1.9,2.1 -1.8,2.2 z m -23.1,-15.5 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" + class="st46" + inkscape:label="CotraspArgCitrA f" + inkscape:connector-curvature="0" + id="F_CotraspArgCitrA" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1915" + class="st15 st38" + x="259.9368" + y="1006.4231">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1917" + class="st15 st38" + x="226.01099" + y="1007.1438">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1919" + class="st15 st38" + x="199.5208" + y="1006.1243">Arg</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1921" + class="st15 st38" + x="273.05161" + y="1006.1243">Arg</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 282.4,1048.3186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -76.6,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z m 60.1,-11.2 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" + class="st140" + inkscape:label="CotraspArgCitrB f" + inkscape:connector-curvature="0" + id="F_CotraspArgCitrB" /><path + style="fill:none;stroke:#000000;stroke-width:3.13730001" + d="m 219.6,1061.9186 c -5.9,-8.2 -5.9,-12.4 -6.5,-16.5 m 62.1,16.4 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m -41.5,14 c -5.9,-8.2 -5.9,-12.4 -6.5,-16.5 m 27.1,16.4 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 26.7,13.9 -84.7,-0.2" + class="st172" + inkscape:label="CotraspArgCitrB" + inkscape:connector-curvature="0" + id="R_CotraspArgCitrB" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1925" + class="st15 st38" + x="258.4368" + y="1040.9231">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1927" + class="st15 st38" + x="224.51099" + y="1041.6438">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1929" + class="st15 st38" + x="198.0208" + y="1040.6243">Arg</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1931" + class="st15 st38" + x="271.55161" + y="1040.6243">Arg</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1933" + class="st15 st16" + x="292.57349" + y="1066.5403">Ci</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1935" + class="st15 st16" + x="182.74879" + y="1067.0325">Ci</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1937" + class="st15 st16" + x="289.01248" + y="1101.4709">Arg</text> +<path + style="fill:none;stroke:#000000;stroke-width:3.19709992" + d="m 237.8,1097.9186 c -6,-8.4 -6,-12.6 -6.6,-16.9 m 29,16.8 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 11.2,13.9 -60.2,-0.3" + class="st171" + inkscape:label="UniportArginine" + inkscape:connector-curvature="0" + id="R_UniportArginine" /><path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 267.4,1084.3186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -51.1,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z" + class="st140" + inkscape:label="UniportArginine f" + inkscape:connector-curvature="0" + id="F_UniportArginine" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1941" + class="st15 st38" + x="261.46759" + y="1076.1584">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1943" + class="st15 st38" + x="226.01099" + y="1077.6438">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1945" + class="st15 st16" + x="180.79909" + y="1101.7258">Arg</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1947" + class="st15 st16" + x="295.41238" + y="1140.4709">Ci</text> +<path + style="fill:none;stroke:#000000;stroke-width:3.19709992" + d="m 246.8,1136.9186 c -6,-8.4 -6,-12.6 -6.6,-16.9 m 29,16.8 c 5.9,-1.5 4.4,-13.9 4.4,-13.9 m 11.2,13.9 -60.2,-0.3" + class="st171" + inkscape:label="UniportCitrulline" + inkscape:connector-curvature="0" + id="R_UniportCitrulline" /><path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 276.4,1123.3186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z m -51.1,11.2 c -2.4,0.8 -4.8,1.6 -7.2,2.4 2.5,0.6 4.9,1.3 7.4,1.9 -0.6,-0.7 -1.3,-1.4 -1.9,-2.1 0.6,-0.7 1.1,-1.4 1.7,-2.2 z" + class="st140" + inkscape:label="UniportCitrulline f" + inkscape:connector-curvature="0" + id="F_UniportCitrulline" /><text + style="font-size:14px;font-family:Calibri-Bold" + id="text1951" + class="st15 st38" + x="270.46759" + y="1115.1584">H</text> +<text + style="font-size:14px;font-family:Calibri-Bold" + id="text1953" + class="st15 st38" + x="235.37189" + y="1114.1194">H</text> +<text + style="font-size:16px;font-family:Calibri-Bold" + id="text1955" + class="st15 st16" + x="202.06329" + y="1141.4475">Ci</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 275.3,1099.8186 c 2.4,-0.8 4.8,-1.6 7.2,-2.4 -2.5,-0.6 -4.9,-1.3 -7.4,-1.9 0.6,0.7 1.3,1.4 1.9,2.1 -0.6,0.8 -1.1,1.5 -1.7,2.2 z m -40.9,-15.5 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.6,0.5 1.4,1 2.2,1.5 z" + class="st140" + inkscape:label="UniportArginine b" + inkscape:connector-curvature="0" + id="B_UniportArginine" /><path + style="fill:none;stroke:#000000;stroke-width:2.32780004" + d="m 243,1123.3186 c -0.6,-1.9 -1.3,-3.9 -1.9,-5.8 -0.9,1.9 -1.9,3.7 -2.8,5.6 0.8,-0.4 1.7,-0.9 2.5,-1.3 0.7,0.5 1.4,1 2.2,1.5 z m 41.3,15.5 c 2.4,-0.8 4.8,-1.6 7.2,-2.4 -2.5,-0.6 -4.9,-1.3 -7.4,-1.9 0.6,0.7 1.3,1.4 1.9,2.1 -0.6,0.8 -1.1,1.5 -1.7,2.2 z" + class="st140" + inkscape:label="UniportCitrulline b" + inkscape:connector-curvature="0" + id="B_UniportCitrulline" /><path + style="fill:none;stroke:#000000;stroke-width:2.22029996" + d="m 1039.7789,1224.1775 0.3,50.4" + class="st68" + inkscape:label="DM_10formylTHFc" + inkscape:connector-curvature="0" + id="R_DM_10formylTHFc" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1960" + class="st15 st16" + x="984.76355" + y="1218.4149">10-formylTHF</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 1037.8789,1273.7775 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" + class="st63" + inkscape:label="DM_10formylTHFc f" + inkscape:connector-curvature="0" + id="F_DM_10formylTHFc" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1963" + class="st15 st16" + x="739.07251" + y="1219.4495">carnitine</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 769.6,1234.7186 0,47.6" + class="st63" + inkscape:label="DM_Carnitine" + inkscape:connector-curvature="0" + id="R_DM_Carnitine" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 769.8,1233.4186 2.2,1.8 -2.2,-7.2 -2.2,7.2 2.2,-1.8 z" + class="st63" + inkscape:label="DM_Carnitine f" + inkscape:connector-curvature="0" + id="F_DM_Carnitine" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 1382.6,1269.2186 2.2,7.2 2.2,-7.2 -2.2,1.8 -2.2,-1.8 z" + class="st63" + inkscape:label="Palmitate_DM_COOP f" + inkscape:connector-curvature="0" + id="F_Palmitate_DM_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 1384.7,1222.0186 0,47.6" + class="st63" + inkscape:label="Palmitate_DM_COOP" + inkscape:connector-curvature="0" + id="R_Palmitate_DM_COOP" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1969" + class="st15 st16" + x="1377.4066" + y="1218.3489">Palm</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 1305.8,1276.7186 -0.3,-48.1" + class="st14" + inkscape:label="Arginine_DM_COOP" + inkscape:connector-curvature="0" + id="R_Arginine_DM_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 1267.8,1232.1186 2.2,-7.7 2.2,7.7 -2.2,-1.9 -2.2,1.9 z" + class="st69" + inkscape:label="Glutamate_DM_COOP b" + inkscape:connector-curvature="0" + id="B_Glutamate_DM_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:3.16359997" + d="m 643.6,1230.3186 2.2,-6.9 2.2,6.9 -2.2,-1.7 -2.2,1.7 z" + class="st65" + inkscape:label="Ex_NH3 b" + inkscape:connector-curvature="0" + id="B_Ex_NH3" /><text + style="font-size:10px;font-family:Calibri" + id="text1974" + class="st17 st18" + x="1314.7279" + y="204.19505">ATP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1976" + class="st17 st18" + x="1294.9379" + y="204.31226">ADP</text> +<path + style="fill:none;stroke:#000000;stroke-width:1.68470001" + d="m 1308.1,213.31855 c -2.4,6.7 3.6,10.9 3.6,10.9 m 15.7,0.2 c -26.9,0 -26.9,0 -26.9,0 m 19.4,-11.1 c 2.4,6.7 -3.6,10.9 -3.6,10.9" + class="st163" + inkscape:label="AK" + inkscape:connector-curvature="0" + id="R_AK" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1303.7,221.91855 c -6.9,2 -6.9,2 -6.9,2 l 6.8,2.4 -1.7,-2.2 1.8,-2.2 z m 1.9,-8.8 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st32" + inkscape:label="AK b" + inkscape:connector-curvature="0" + id="B_AK" /><path + style="fill:none;stroke:#000000;stroke-width:2.44919991" + d="m 1327.4,222.21855 c 6.9,2 6.9,2 6.9,2 l -6.8,2.4 1.7,-2.2 -1.8,-2.2 z m -8.6,-9.1 c 2,-4.9 2,-4.9 2,-4.9 l 1.3,5.6 -1.6,-1.7 -1.7,1 z" + class="st32" + inkscape:label="AK f" + inkscape:connector-curvature="0" + id="F_AK" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text1981" + class="st15 st16" + x="1341.2035" + y="225.97145">dAMP</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1983" + class="st17 st18" + x="422.99298" + y="130.87186">H</text> +<text + style="font-size:6.5px;font-family:Calibri" + id="text1985" + class="st17 st173" + x="429.22339" + y="132.87186">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1987" + class="st17 st18" + x="432.51788" + y="130.87186">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1989" + class="st17 st18" + x="427.66238" + y="118.75516">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.0948" + d="m 457.5,136.01855 0,-31.1 0,31.1 z m -0.4,-14.7 c -0.9,-5.5 -11.1,-5.3 -11.1,-5.3 m -3.6,11.8 c 8.8,2.9 14.6,-3.3 14.6,-3.3" + class="st76" + inkscape:label="G6PPer" + inkscape:connector-curvature="0" + id="R_G6PPer" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 447,117.71855 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z m 12.1,-10.7 c -1.7,-7.299996 -1.7,-7.299996 -1.7,-7.299996 l -1.7,7.299996 1.7,-1.8 1.7,1.8 z" + class="st30" + inkscape:label="F G6PPer" + inkscape:connector-curvature="0" + id="F_G6PPer" /><path + style="fill:none;stroke:#000000;stroke-width:2.0948" + d="m 457.9,245.51855 0,-31.1 0,31.1 z m -0.4,-14.8 c -0.9,-5.5 -11.1,-5.3 -11.1,-5.3 m -3.6,11.9 c 8.8,2.9 14.6,-3.3 14.6,-3.3" + class="st76" + inkscape:transform-center-y="-61.654422" + inkscape:transform-center-x="138.9285" + inkscape:connector-curvature="0" + id="R_FBP" /><path + style="fill:none;stroke:#000000;stroke-width:1.87170005" + d="m 447.4,227.21855 c -4.9,-2 -4.9,-2 -4.9,-2 l 5.6,-1.3 -1.7,1.6 1,1.7 z m 12.1,-10.7 c -1.7,-7.3 -1.7,-7.3 -1.7,-7.3 l -1.7,7.3 1.7,-1.8 1.7,1.8 z" + class="st30" + inkscape:transform-center-y="-76.278967" + inkscape:transform-center-x="138.06632" + inkscape:label="FBP f" + inkscape:connector-curvature="0" + id="F_FBP" /><text + style="font-size:10px;font-family:Calibri" + id="text1995" + class="st17 st18" + x="424.16238" + y="240.49146">H</text> +<text + style="font-size:6.5px;font-family:Calibri" + id="text1997" + class="st17 st173" + x="430.39288" + y="242.49146">2</text> +<text + style="font-size:10px;font-family:Calibri" + id="text1999" + class="st17 st18" + x="433.6868" + y="240.49146">O</text> +<text + style="font-size:10px;font-family:Calibri" + id="text2001" + class="st17 st18" + x="428.83179" + y="228.37425">Pi</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.17810011" + d="m 1405.8,1229.0186 0,47.6" + class="st63" + inkscape:label="Palmitate_UP_COOP" + inkscape:connector-curvature="0" + id="R_Palmitate_UP_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 1403.7,1233.9186 2.1,-7.3 2.3,7.3 -2.2,-1.8 -2.2,1.8 z" + class="st14" + inkscape:label="Palmitate_UP_COOP f" + inkscape:connector-curvature="0" + id="F_Palmitate_UP_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 767.6,1278.0186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" + class="st69" + inkscape:label="DM_Carnitine b" + inkscape:connector-curvature="0" + id="B_DM_Carnitine" /><path + style="fill:none;stroke:#000000;stroke-width:2.67510009" + d="m 964.1,1232.4186 -2.2,-7.1 -2.2,7.1 2.2,-1.8 2.2,1.8 z" + class="st64" + inkscape:label="UptakeCitrate f" + inkscape:connector-curvature="0" + id="F_UptakeCitrate" /><path + style="fill:none;stroke:#000000;stroke-width:2.67510009" + d="m 962,1278.6186 0,-46.6" + class="st64" + inkscape:label="DM_Citrate" + inkscape:connector-curvature="0" + id="R_DM_Citrate" /><text + style="font-size:16px;font-family:Calibri-Bold" + id="text2008" + class="st15 st16" + x="952.39581" + y="1218.1301">Cit</text> +<path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 959.6,1276.4186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" + class="st69" + inkscape:label="UptakeCitrate b" + inkscape:connector-curvature="0" + id="B_UptakeCitrate" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 1174.9998,1273.8805 -2.1,7.3 -2.3,-7.3 2.2,1.8 2.2,-1.8 z" + class="st14" + inkscape:label="Glucose_DM_COOP f" + inkscape:connector-curvature="0" + id="F_Glucose_DM_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 1137.2,1273.5186 2.2,7.7 2.2,-7.7 -2.2,1.9 -2.2,-1.9 z" + class="st69" + inkscape:label="LactateL_DM_COOP f" + inkscape:connector-curvature="0" + id="F_DM_LactateL" /><path + style="fill:none;stroke:#000000;stroke-width:2.22930002" + d="m 1139.2,1223.4186 0,50.5" + class="st69" + inkscape:label="LactateL_DM_COOP" + inkscape:connector-curvature="0" + id="R_LactateL_DM_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 1231.89,1231.8186 2.2,-7.3 2.2,7.3 -2.2,-1.8 -2.2,1.8 z" + class="st14" + inkscape:label="Glutamine_DM_COOP b" + inkscape:connector-curvature="0" + id="B_Glutamine_DM_COOP" /><path + style="fill:none;stroke:#000000;stroke-width:2.18210006" + d="m 1233.89,1279.4186 0,-48" + class="st14" + inkscape:label="Glutamine_DM_COOP" + inkscape:connector-curvature="0" + id="R_Glutamine_DM_COOP" /><flowRoot + xml:space="preserve" + id="flowRoot5366" + style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" + transform="translate(-20.6,18.418554)"><flowRegion + id="flowRegion5368"><rect + id="rect5370" + width="1165.1471" + height="77.465683" + x="306.70087" + y="-39.523308" /></flowRegion><flowPara + id="flowPara5372" /></flowRoot><flowRoot + xml:space="preserve" + id="TitoloConfronto" + style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" + inkscape:label="TitoloConfronto" + transform="translate(-18.364224,56.426743)"><flowRegion + id="flowRegion5376"><rect + id="rect5378" + width="1869.6877" + height="68.569115" + x="301.95807" + y="-69.56102" /></flowRegion><flowPara + id="TitleText" + style="font-style:normal;font-variant:normal;font-weight:normal;font-stretch:normal;font-size:45px;font-family:sans-serif;-inkscape-font-specification:sans-serif">TITOLO: TITOLOTITOLO </flowPara></flowRoot><flowRoot + xml:space="preserve" + id="flowRoot5382" + style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" + transform="translate(-16.64767,38.180207)"><flowRegion + id="flowRegion5384"><rect + id="rect5386" + width="275.00043" + height="149.79698" + x="1681.3033" + y="204.59315" /></flowRegion><flowPara + id="flowPara5390" + style="font-style:normal;font-variant:normal;font-weight:bold;font-stretch:normal;font-family:sans-serif;-inkscape-font-specification:'sans-serif Bold'">Fold Change</flowPara></flowRoot><flowRoot + xml:space="preserve" + id="FC_min" + style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" + transform="translate(-8.622366,131.05768)" + inkscape:label="FC_min"><flowRegion + id="flowRegion5384-2"><rect + id="rect5386-9" + width="275.00043" + height="149.79698" + x="1681.3033" + y="204.59315" /></flowRegion><flowPara + id="Val_FC_min">min: </flowPara></flowRoot><flowRoot + xml:space="preserve" + id="FC_max" + style="font-style:normal;font-weight:normal;font-size:35px;line-height:125%;font-family:sans-serif;letter-spacing:0px;word-spacing:0px;fill:#000000;fill-opacity:1;stroke:none;stroke-width:1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" + transform="translate(-17.492772,95.648076)" + inkscape:label="FC_max"><flowRegion + id="flowRegion5384-2-2"><rect + id="rect5386-9-9" + width="275.00043" + height="149.79698" + x="1681.3033" + y="204.59315" /></flowRegion><flowPara + id="Val_FC_max">max:</flowPara></flowRoot></svg> \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/Marea/marea.py Tue Nov 06 03:16:21 2018 -0500 @@ -0,0 +1,760 @@ + +from __future__ import division +import sys +import pandas as pd +import itertools as it +import scipy.stats as st +import collections +import lxml.etree as ET +import pickle as pk +import math +import os +import argparse +from svglib.svglib import svg2rlg +from reportlab.graphics import renderPDF + +########################## argparse ########################################### + +def process_args(args): + parser = argparse.ArgumentParser(usage = '%(prog)s [options]', + description = 'process some value\'s'+ + ' genes to create a comparison\'s map.') + parser.add_argument('-rs', '--rules_selector', + type = str, + default = 'HMRcore', + choices = ['HMRcore', 'Recon', 'Custom'], + help = 'chose which type of dataset you want use') + parser.add_argument('-cr', '--custom', + type = str, + help='your dataset if you want custom rules') + parser.add_argument('-na', '--names', + type = str, + nargs = '+', + help = 'input names') + parser.add_argument('-n', '--none', + type = str, + default = 'true', + choices = ['true', 'false'], + help = 'compute Nan values') + parser.add_argument('-pv' ,'--pValue', + type = float, + default = 0.05, + help = 'P-Value threshold (default: %(default)s)') + parser.add_argument('-fc', '--fChange', + type = float, + default = 1.5, + help = 'Fold-Change threshold (default: %(default)s)') + parser.add_argument('-td', '--tool_dir', + type = str, + required = True, + help = 'your tool directory') + parser.add_argument('-op', '--option', + type = str, + choices = ['datasets', 'dataset_class'], + help='dataset or dataset and class') + parser.add_argument('-ol', '--out_log', + help = "Output log") + parser.add_argument('-ids', '--input_datas', + type = str, + nargs = '+', + help = 'input datasets') + parser.add_argument('-id', '--input_data', + type = str, + help = 'input dataset') + parser.add_argument('-ic', '--input_class', + type = str, + help = 'sample group specification') + parser.add_argument('-cm', '--custom_map', + type = str, + help = 'custom map') + parser.add_argument('-yn', '--yes_no', + type = str, + choices = ['yes', 'no'], + help = 'if make or not custom map') + args = parser.parse_args() + return args + +########################### warning ########################################### + +def warning(s): + args = process_args(sys.argv) + with open(args.out_log, 'a') as log: + log.write(s) + +############################ dataset input #################################### + +def read_dataset(data, name): + try: + dataset = pd.read_csv(data, sep = '\t', header = 0) + except pd.errors.EmptyDataError: + sys.exit('Execution aborted: wrong format of ' + name + '\n') + if len(dataset.columns) < 2: + sys.exit('Execution aborted: wrong format of ' + name + '\n') + return dataset + +############################ dataset name ##################################### + +def name_dataset(name_data, count): + if str(name_data) == 'Dataset': + return str(name_data) + '_' + str(count) + else: + return str(name_data) + +############################ load id e rules ################################## + +def load_id_rules(reactions): + ids, rules = [], [] + for key, value in reactions.items(): + ids.append(key) + rules.append(value) + return (ids, rules) + +############################ check_methods #################################### + +def gene_type(l, name): + if check_hgnc(l): + return 'hugo_id' + elif check_ensembl(l): + return 'ensembl_gene_id' + elif check_symbol(l): + return 'symbol' + elif check_entrez(l): + return 'entrez_id' + else: + sys.exit('Execution aborted:\n' + + 'gene ID type in ' + name + ' not supported. Supported ID'+ + 'types are: HUGO ID, Ensemble ID, HUGO symbol, Entrez ID\n') + +def check_hgnc(l): + if len(l) > 5: + if (l.upper()).startswith('HGNC:'): + return l[5:].isdigit() + else: + return False + else: + return False + +def check_ensembl(l): + if len(l) == 15: + if (l.upper()).startswith('ENS'): + return l[4:].isdigit() + else: + return False + else: + return False + +def check_symbol(l): + if len(l) > 0: + if l[0].isalpha() and l[1:].isalnum(): + return True + else: + return False + else: + return False + +def check_entrez(l): + if len(l) > 0: + return l.isdigit() + else: + return False + +def check_bool(b): + if b == 'true': + return True + elif b == 'false': + return False + +############################ resolve_methods ################################## + +def replace_gene_value(l, d): + tmp = [] + err = [] + while l: + if isinstance(l[0], list): + tmp_rules, tmp_err = replace_gene_value(l[0], d) + tmp.append(tmp_rules) + err.extend(tmp_err) + else: + value = replace_gene(l[0], d) + tmp.append(value) + if value == None: + err.append(l[0]) + l = l[1:] + return (tmp, err) + +def replace_gene(l, d): + if l =='and' or l == 'or': + return l + else: + value = d.get(l, None) + if not(value == None or isinstance(value, (int, float))): + sys.exit('Execution aborted: ' + value + ' value not valid\n') + return value + +def computes(val1, op, val2, cn): + if val1 != None and val2 != None: + if op == 'and': + return min(val1, val2) + else: + return val1 + val2 + elif op == 'and': + if cn is True: + if val1 != None: + return val1 + elif val2 != None: + return val2 + else: + return None + else: + return None + else: + if val1 != None: + return val1 + elif val2 != None: + return val2 + else: + return None + +def control(ris, l, cn): + if len(l) == 1: + if isinstance(l[0], (float, int)) or l[0] == None: + return l[0] + elif isinstance(l[0], list): + return control(None, l[0], cn) + else: + return False + elif len(l) > 2: + return control_list(ris, l, cn) + else: + return False + +def control_list(ris, l, cn): + while l: + if len(l) == 1: + return False + elif (isinstance(l[0], (float, int)) or + l[0] == None) and l[1] in ['and', 'or']: + if isinstance(l[2], (float, int)) or l[2] == None: + ris = computes(l[0], l[1], l[2], cn) + elif isinstance(l[2], list): + tmp = control(None, l[2], cn) + if tmp is False: + return False + else: + ris = computes(l[0], l[1], tmp, cn) + else: + return False + l = l[3:] + elif l[0] in ['and', 'or']: + if isinstance(l[1], (float, int)) or l[1] == None: + ris = computes(ris, l[0], l[1], cn) + elif isinstance(l[1], list): + tmp = control(None,l[1], cn) + if tmp is False: + return False + else: + ris = computes(ris, l[0], tmp, cn) + else: + return False + l = l[2:] + elif isinstance(l[0], list) and l[1] in ['and', 'or']: + if isinstance(l[2], (float, int)) or l[2] == None: + tmp = control(None, l[0], cn) + if tmp is False: + return False + else: + ris = computes(tmp, l[1], l[2], cn) + elif isinstance(l[2], list): + tmp = control(None, l[0], cn) + tmp2 = control(None, l[2], cn) + if tmp is False or tmp2 is False: + return False + else: + ris = computes(tmp, l[1], tmp2, cn) + else: + return False + l = l[3:] + else: + return False + return ris + +############################ map_methods ###################################### + +def fold_change(avg1, avg2): + if avg1 == 0 and avg2 == 0: + return 0 + elif avg1 == 0: + return '-INF' + elif avg2 == 0: + return 'INF' + else: + return math.log(avg1 / avg2, 2) + +def fix_style(l, col, width, dash): + tmp = l.split(';') + flag_col = False + flag_width = False + flag_dash = False + for i in range(len(tmp)): + if tmp[i].startswith('stroke:'): + tmp[i] = 'stroke:' + col + flag_col = True + if tmp[i].startswith('stroke-width:'): + tmp[i] = 'stroke-width:' + width + flag_width = True + if tmp[i].startswith('stroke-dasharray:'): + tmp[i] = 'stroke-dasharray:' + dash + flag_dash = True + if not flag_col: + tmp.append('stroke:' + col) + if not flag_width: + tmp.append('stroke-width:' + width) + if not flag_dash: + tmp.append('stroke-dasharray:' + dash) + return ';'.join(tmp) + +def fix_map(d, core_map, threshold_P_V, threshold_F_C, max_F_C): + maxT = 12 + minT = 2 + grey = '#BEBEBE' + blue = '#0000FF' + red = '#E41A1C' + for el in core_map.iter(): + el_id = str(el.get('id')) + if el_id.startswith('R_'): + tmp = d.get(el_id[2:]) + if tmp != None: + p_val = tmp[0] + f_c = tmp[1] + if p_val < threshold_P_V: + if not isinstance(f_c, str): + if abs(f_c) < math.log(threshold_F_C, 2): + col = grey + width = str(minT) + else: + if f_c < 0: + col = blue + elif f_c > 0: + col = red + width = str(max((abs(f_c) * maxT) / max_F_C, minT)) + else: + if f_c == '-INF': + col = blue + elif f_c == 'INF': + col = red + width = str(maxT) + dash = 'none' + else: + dash = '5,5' + col = grey + width = str(minT) + el.set('style', fix_style(el.get('style'), col, width, dash)) + return core_map + +############################ make recon ####################################### + +def check_and_doWord(l): + tmp = [] + tmp_genes = [] + count = 0 + while l: + if count >= 0: + if l[0] == '(': + count += 1 + tmp.append(l[0]) + l.pop(0) + elif l[0] == ')': + count -= 1 + tmp.append(l[0]) + l.pop(0) + elif l[0] == ' ': + l.pop(0) + else: + word = [] + while l: + if l[0] in [' ', '(', ')']: + break + else: + word.append(l[0]) + l.pop(0) + word = ''.join(word) + tmp.append(word) + if not(word in ['or', 'and']): + tmp_genes.append(word) + else: + return False + if count == 0: + return (tmp, tmp_genes) + else: + return False + +def brackets_to_list(l): + tmp = [] + while l: + if l[0] == '(': + l.pop(0) + tmp.append(resolve_brackets(l)) + else: + tmp.append(l[0]) + l.pop(0) + return tmp + +def resolve_brackets(l): + tmp = [] + while l[0] != ')': + if l[0] == '(': + l.pop(0) + tmp.append(resolve_brackets(l)) + else: + tmp.append(l[0]) + l.pop(0) + l.pop(0) + return tmp + +def priorityAND(l): + tmp = [] + flag = True + while l: + if len(l) == 1: + if isinstance(l[0], list): + tmp.append(priorityAND(l[0])) + else: + tmp.append(l[0]) + l = l[1:] + elif l[0] == 'or': + tmp.append(l[0]) + flag = False + l = l[1:] + elif l[1] == 'or': + if isinstance(l[0], list): + tmp.append(priorityAND(l[0])) + else: + tmp.append(l[0]) + tmp.append(l[1]) + flag = False + l = l[2:] + elif l[1] == 'and': + tmpAnd = [] + if isinstance(l[0], list): + tmpAnd.append(priorityAND(l[0])) + else: + tmpAnd.append(l[0]) + tmpAnd.append(l[1]) + if isinstance(l[2], list): + tmpAnd.append(priorityAND(l[2])) + else: + tmpAnd.append(l[2]) + l = l[3:] + while l: + if l[0] == 'and': + tmpAnd.append(l[0]) + if isinstance(l[1], list): + tmpAnd.append(priorityAND(l[1])) + else: + tmpAnd.append(l[1]) + l = l[2:] + elif l[0] == 'or': + flag = False + break + if flag == True: #se ci sono solo AND nella lista + tmp.extend(tmpAnd) + elif flag == False: + tmp.append(tmpAnd) + return tmp + +def checkRule(l): + if len(l) == 1: + if isinstance(l[0], list): + if checkRule(l[0]) is False: + return False + elif len(l) > 2: + if checkRule2(l) is False: + return False + else: + return False + return True + +def checkRule2(l): + while l: + if len(l) == 1: + return False + elif isinstance(l[0], list) and l[1] in ['and', 'or']: + if checkRule(l[0]) is False: + return False + if isinstance(l[2], list): + if checkRule(l[2]) is False: + return False + l = l[3:] + elif l[1] in ['and', 'or']: + if isinstance(l[2], list): + if checkRule(l[2]) is False: + return False + l = l[3:] + elif l[0] in ['and', 'or']: + if isinstance(l[1], list): + if checkRule(l[1]) is False: + return False + l = l[2:] + else: + return False + return True + +def do_rules(rules): + split_rules = [] + err_rules = [] + tmp_gene_in_rule = [] + for i in range(len(rules)): + tmp = list(rules[i]) + if tmp: + tmp, tmp_genes = check_and_doWord(tmp) + tmp_gene_in_rule.extend(tmp_genes) + if tmp is False: + split_rules.append([]) + err_rules.append(rules[i]) + else: + tmp = brackets_to_list(tmp) + if checkRule(tmp): + split_rules.append(priorityAND(tmp)) + else: + split_rules.append([]) + err_rules.append(rules[i]) + else: + split_rules.append([]) + if err_rules: + warning('Warning: wrong format rule in ' + str(err_rules) + '\n') + return (split_rules, list(set(tmp_gene_in_rule))) + +def make_recon(data): + try: + import cobra as cb + import warnings + with warnings.catch_warnings(): + warnings.simplefilter('ignore') + recon = cb.io.read_sbml_model(data) + react = recon.reactions + rules = [react[i].gene_reaction_rule for i in range(len(react))] + ids = [react[i].id for i in range(len(react))] + except cb.io.sbml3.CobraSBMLError: + try: + data = (pd.read_csv(data, sep = '\t', dtype = str)).fillna('') + if len(data.columns) < 2: + sys.exit('Execution aborted: wrong format of '+ + 'custom datarules\n') + if not len(data.columns) == 2: + warning('Warning: more than 2 columns in custom datarules.\n' + + 'Extra columns have been disregarded\n') + ids = list(data.iloc[:, 0]) + rules = list(data.iloc[:, 1]) + except pd.errors.EmptyDataError: + sys.exit('Execution aborted: wrong format of custom datarules\n') + except pd.errors.ParserError: + sys.exit('Execution aborted: wrong format of custom datarules\n') + split_rules, tmp_genes = do_rules(rules) + gene_in_rule = {} + for i in tmp_genes: + gene_in_rule[i] = 'ok' + return (ids, split_rules, gene_in_rule) + +############################ gene ############################################# + +def data_gene(gene, type_gene, name, gene_custom): + args = process_args(sys.argv) + for i in range(len(gene)): + tmp = gene.iloc[i, 0] + if tmp.startswith(' ') or tmp.endswith(' '): + gene.iloc[i, 0] = (tmp.lstrip()).rstrip() + gene_dup = [item for item, count in + collections.Counter(gene[gene.columns[0]]).items() if count > 1] + pat_dup = [item for item, count in + collections.Counter(list(gene.columns)).items() if count > 1] + if gene_dup: + if gene_custom == None: + if args.rules_selector == 'HMRcore': + gene_in_rule = pk.load(open(args.tool_dir + + '/local/HMRcore_genes.p', 'rb')) + elif args.rules_selector == 'Recon': + gene_in_rule = pk.load(open(args.tool_dir + + '/local/Recon_genes.p', 'rb')) + gene_in_rule = gene_in_rule.get(type_gene) + else: + gene_in_rule = gene_custom + tmp = [] + for i in gene_dup: + if gene_in_rule.get(i) == 'ok': + tmp.append(i) + if tmp: + sys.exit('Execution aborted because gene ID ' + +str(tmp)+' in '+name+' is duplicated\n') + if pat_dup: + warning('Warning: duplicated label\n' + str(pat_dup) + 'in ' + name + + '\n') + return (gene.set_index(gene.columns[0])).to_dict() + +############################ resolve ########################################## + +def resolve(genes, rules, ids, resolve_none, name): + resolve_rules = {} + not_found = [] + flag = False + for key, value in genes.items(): + tmp_resolve = [] + for i in range(len(rules)): + tmp = rules[i] + if tmp: + tmp, err = replace_gene_value(tmp, value) + if err: + not_found.extend(err) + ris = control(None, tmp, resolve_none) + if ris is False or ris == None: + tmp_resolve.append(None) + else: + tmp_resolve.append(ris) + flag = True + else: + tmp_resolve.append(None) + resolve_rules[key] = tmp_resolve + if flag is False: + warning('Warning: no computable score (due to missing gene values)' + + 'for class ' + name + ', the class has been disregarded\n') + return (None, None) + return (resolve_rules, list(set(not_found))) + +############################ split class ###################################### + +def split_class(classes, resolve_rules): + class_pat = {} + for i in range(len(classes)): + classe = classes.iloc[i, 1] + if not pd.isnull(classe): + l = [] + for j in range(i, len(classes)): + if classes.iloc[j, 1] == classe: + pat_id = classes.iloc[j, 0] + tmp = resolve_rules.get(pat_id, None) + if tmp != None: + l.append(tmp) + classes.iloc[j, 1] = None + if l: + class_pat[classe] = list(map(list, zip(*l))) + else: + warning('Warning: no sample found in class ' + classe + + ', the class has been disregarded\n') + return class_pat + +############################ map ############################################## + +def maps(core_map, class_pat, ids, threshold_P_V, threshold_F_C): + args = process_args(sys.argv) + if (not class_pat) or (len(class_pat.keys()) < 2): + sys.exit('Execution aborted: classes provided for comparisons are ' + + 'less than two\n') + for i, j in it.combinations(class_pat.keys(), 2): + tmp = {} + count = 0 + max_F_C = 0 + for l1, l2 in zip(class_pat.get(i), class_pat.get(j)): + try: + stat_D, p_value = st.ks_2samp(l1, l2) + avg = fold_change(sum(l1) / len(l1), sum(l2) / len(l2)) + if not isinstance(avg, str): + if max_F_C < abs(avg): + max_F_C = abs(avg) + tmp[ids[count]] = [float(p_value), avg] + count += 1 + except (TypeError, ZeroDivisionError): + count += 1 + tab = 'table_out/' + i + '_vs_' + j + '.tsv' + tmp_csv = pd.DataFrame.from_dict(tmp, orient = "index") + tmp_csv = tmp_csv.reset_index() + header = ['ids', 'P_Value', 'Average'] + tmp_csv.to_csv(tab, sep = '\t', index = False, header = header) + if args.rules_selector == 'HMRcore' or (args.rules_selector == 'Custom' + and args.yes_no == 'yes'): + fix_map(tmp, core_map, threshold_P_V, threshold_F_C, max_F_C) + file_svg = 'map_svg/' + i + '_vs_' + j + '.svg' + with open(file_svg, 'wb') as new_map: + new_map.write(ET.tostring(core_map, encoding='UTF-8', + method='xml')) + file_pdf = 'map_pdf/' + i + '_vs_' + j + '.pdf' + renderPDF.drawToFile(svg2rlg(file_svg), file_pdf) + return None + +############################ MAIN ############################################# + +def main(): + args = process_args(sys.argv) + os.makedirs('table_out') + if args.rules_selector == 'HMRcore': + os.makedirs('map_svg') + os.makedirs('map_pdf') + recon = pk.load(open(args.tool_dir + '/local/HMRcore_rules.p', 'rb')) + elif args.rules_selector == 'Recon': + recon = pk.load(open(args.tool_dir + '/local/Recon_rules.p', 'rb')) + elif args.rules_selector == 'Custom': + ids, rules, gene_in_rule = make_recon(args.custom) + resolve_none = check_bool(args.none) + class_pat = {} + if args.option == 'datasets': + num = 1 + #if len(args.names) != len(set(args.names)): + # sys.exit('Execution aborted: datasets name duplicated') + for i, j in zip(args.input_datas, args.names): + name = name_dataset(j, num) + dataset = read_dataset(i, name) + dataset.iloc[:, 0] = (dataset.iloc[:, 0]).astype(str) + type_gene = gene_type(dataset.iloc[0, 0], name) + if args.rules_selector != 'Custom': + genes = data_gene(dataset, type_gene, name, None) + ids, rules = load_id_rules(recon.get(type_gene)) + elif args.rules_selector == 'Custom': + genes = data_gene(dataset, type_gene, name, gene_in_rule) + resolve_rules, err = resolve(genes, rules, ids, resolve_none, name) + if err != None and err: + warning('Warning: gene\n' + str(err) + '\nnot found in class ' + + name + ', the expression level for this gene ' + + 'will be considered NaN\n') + if resolve_rules != None: + class_pat[name] = list(map(list, zip(*resolve_rules.values()))) + num += 1 + elif args.option == 'dataset_class': + name = 'RNAseq' + dataset = read_dataset(args.input_data, name) + dataset.iloc[:, 0] = (dataset.iloc[:, 0]).astype(str) + type_gene = gene_type(dataset.iloc[0, 0], name) + classes = read_dataset(args.input_class, 'class') + if not len(classes.columns) == 2: + warning('Warning: more than 2 columns in class file. Extra' + + 'columns have been disregarded\n') + classes = classes.astype(str) + if args.rules_selector != 'Custom': + genes = data_gene(dataset, type_gene, name, None) + ids, rules = load_id_rules(recon.get(type_gene)) + elif args.rules_selector == 'Custom': + genes = data_gene(dataset, type_gene, name, gene_in_rule) + resolve_rules, err = resolve(genes, rules, ids, resolve_none, name) + if err != None and err: + warning('Warning: gene\n'+str(err)+'\nnot found in class ' + + name + ', the expression level for this gene ' + + 'will be considered NaN\n') + if resolve_rules != None: + class_pat = split_class(classes, resolve_rules) + if args.rules_selector == 'Custom': + if args.yes_no == 'yes': + os.makedirs('map_svg') + os.makedirs('map_pdf') + try: + core_map = ET.parse(args.custom_map) + except (ET.XMLSyntaxError, ET.XMLSchemaParseError): + sys.exit('Execution aborted: custom map in wrong format') + elif args.yes_no == 'no': + core_map = ET.parse(args.tool_dir + '/local/HMRcoreMap.svg') + else: + core_map = ET.parse(args.tool_dir+'/local/HMRcoreMap.svg') + maps(core_map, class_pat, ids, args.pValue, args.fChange) + warning('Execution succeeded') + return None + +############################################################################### + +if __name__ == "__main__": + main()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/Marea/marea.xml Tue Nov 06 03:16:21 2018 -0500 @@ -0,0 +1,240 @@ +<tool id="MaREA" name="Metabolic Enrichment Analysis"> + <description>for Galaxy</description> + <requirements> + <requirement type="package">pandas</requirement> + <requirement type="package">scipy</requirement> + <requirement type="package">lxml</requirement> + <requirement type="package">svglib</requirement> + <requirement type="package">reportlab</requirement> + <requirement type="package">cobrapy</requirement> + <requirement type="package">python-libsbml</requirement> + </requirements> + <command> + <![CDATA[ + python $__tool_directory__/marea.py + --rules_selector $cond_rule.rules_selector + #if $cond_rule.rules_selector == 'Custom': + --custom ${cond_rule.Custom_rules} + --yes_no ${cond_rule.cond_map.yes_no} + #if $cond_rule.cond_map.yes_no == 'yes': + --custom_map $cond_rule.cond_map.Custom_map + #end if + #end if + --none $None + --pValue $pValue + --fChange $fChange + --tool_dir $__tool_directory__ + --option $cond.type_selector + --out_log $log + #if $cond.type_selector == 'datasets': + --input_datas + #for $data in $cond.input_Datasets: + ${data.input} + #end for + --names + #for $data in $cond.input_Datasets: + ${data.input_name} + #end for + #elif $cond.type_selector == 'dataset_class': + --input_data ${input_data} + --input_class ${input_class} + #end if + ]]> + </command> + <inputs> + <conditional name="cond_rule"> + <param name="rules_selector" type="select" label="Gene-Protein-Reaction rules:"> + <option value="HMRcore" selected="true">HMRcore rules</option> + <option value="Recon">Recon 2.2 rules</option> + <option value="Custom">Custom rules</option> + </param> + <when value="Custom"> + <param name="Custom_rules" type="data" format="tabular, csv, tsv, xml" label="Custom rules"/> + <conditional name="cond_map"> + <param name="yes_no" type="select" label="Custom map? (optional)"> + <option value="no" selected="true">no</option> + <option value="yes">yes</option> + </param> + <when value="yes"> + <param name="Custom_map" type="data" format="xml, svg" label="custom-map.svg"/> + </when> + </conditional> + </when> + </conditional> + <conditional name="cond"> + <param name="type_selector" type="select" label="Input format:"> + <option value="datasets" selected="true">RNAseq of group 1 + RNAseq of group 2 + … + RNAseq of group N</option> + <option value="dataset_class">RNAseq of all samples + sample group specification</option> + </param> + <when value="datasets"> + <repeat name="input_Datasets" title="RNAseq" type="data" min="2"> + <param name="input" type="data" format="tabular, csv, tsv" label="add dataset"/> + <param name="input_name" type="text" label="Dataset's name:" value="Dataset" help="Defalut: Dataset"/> + </repeat> + </when> + <when value="dataset_class"> + <param name="input_data" type="data" format="tabular, csv, tsv" label="RNAseq of all samples"/> + <param name="input_class" type="data" format="tabular, csv, tsv" label="Sample group specification"/> + </when> + </conditional> + <param name="None" type="boolean" truevalue="true" falsevalue="false" checked="true" label="(A and NaN) solved as (A)?"/> + <param name="pValue" type="float" size="20" value="0.05" max="1" min="0" label="P-value threshold" help="min value 0"/> + <param name="fChange" type="float" size="20" value="1.5" min="1" label="Fold-Cahnge threshold" help="min value 1"/> + </inputs> + <outputs> + <data format="txt" name="log" label="Log"/> + <collection name="map_svg" type="list" label="file svg"> + <filter>(cond_rule['rules_selector'] == 'HMRcore') or ((cond_rule['rules_selector'] == 'Custom') and (cond_rule['cond_map']['yes_no'] == 'yes'))</filter> + <discover_datasets pattern="__name_and_ext__" directory="map_svg"/> + </collection> + <collection name="map_pdf" type="list" label="file pdf"> + <filter>(cond_rule['rules_selector'] == 'HMRcore') or ((cond_rule['rules_selector'] == 'Custom') and (cond_rule['cond_map']['yes_no'] == 'yes'))</filter> + <discover_datasets pattern="__name_and_ext__" directory="map_pdf"/> + </collection> + <collection name="table_out" type="list" label="file table"> + <discover_datasets pattern="__name_and_ext__" directory="table_out"/> + </collection> + </outputs> + <help> +<![CDATA[ + +What it does +------------- + +This tool analyzes RNA-seq dataset(s) as described in Graudenzi et al."`MaREA`_: Metabolic feature extraction, enrichment and visualization of RNAseq data" bioRxiv (2018): 248724. + +The tool can be used to generate: + 1) a tab-separated file: reporting fold-change and p-values of reaction activity scores (RASs) between a pair of conditions/classes + 2) a metabolic map file (downlodable as .svg): visualizing up- and down-regulated reactions between a pair of conditions/classes + 3) a log file (.txt) + +Accepted files are: + 1) or two or more RNA-seq datasets, each referring to samples in a given condition/class. The user can specify a label for each class (as e.g. “classA” and “classB”). + 2) or one RNA dataset and one class-file specifying the class/condition each sample belongs to. + + +RNA-seq datasets format: tab-separated text files, reporting the expression level (e.g., TPM, RPKM, …) of each gene (row) for a given sample (column). Header: sample ID. + +Class-file format: each row of the class-file reports the sample ID (column1) and the label of the class/condition the sample belongs to (column 2). + +To calculate P-Values and Fold-Changes and to generate maps, comparisons are performed for each possible pair of classes. + +Output files will be named as classA_vs_classB. Reactions will conventionally be reported as up-regulated (down-regulated) if they are significantly more (less) active in class having label “classA”. + +.. _MaREA: https://www.biorxiv.org/content/early/2018/01/16/248724 + + +Example input +------------- + +**"RNAseq of group 1 + RNAseq of group 2 + ... + RNAseq of group N" exemple input"** option: + +Dataset 1: + ++------------+------------+------------+------------+ +| Hugo_ID | TCGAA62670 | TCGAA62671 | TCGAA62672 | ++============+============+============+============+ +| HGNC:24086 | 0.523167 | 0.371355 | 0.925661 | ++------------+------------+------------+------------+ +| HGNC:24086 | 0.568765 | 0.765567 | 0.456789 | ++------------+------------+------------+------------+ +| HGNC:9876 | 0.876545 | 0.768933 | 0.987654 | ++------------+------------+------------+------------+ +| HGNC:9 | 0.456788 | 0.876543 | 0.876542 | ++------------+------------+------------+------------+ +| HGNC:23 | 0.876543 | 0.786543 | 0.897654 | ++------------+------------+------------+------------+ + +| + +Dataset 2: + ++-------------+------------+------------+------------+ +| Hugo_Symbol | TCGAA62670 | TCGAA62671 | TCGAA62672 | ++=============+============+============+============+ +| A1BG | 0.523167 | 0.371355 | 0.925661 | ++-------------+------------+------------+------------+ +| A1CF | 0.568765 | 0.765567 | 0.456789 | ++-------------+------------+------------+------------+ +| A2M | 0.876545 | 0.768933 | 0.987654 | ++-------------+------------+------------+------------+ +| A4GALT | 0.456788 | 0.876543 | 0.876542 | ++-------------+------------+------------+------------+ +| M664Y65 | 0.876543 | 0.786543 | 0.897654 | ++-------------+------------+------------+------------+ + +| + +**"RNAseq of all samples + sample group specification"** option: + +Dataset: + ++------------+------------+------------+------------+ +| Hugo_ID | TCGAA62670 | TCGAA62671 | TCGAA62672 | ++============+============+============+============+ +| HGNC:24086 | 0.523167 | 0.371355 | 0.925661 | ++------------+------------+------------+------------+ +| HGNC:24086 | 0.568765 | 0.765567 | 0.456789 | ++------------+------------+------------+------------+ +| HGNC:9876 | 0.876545 | 0.768933 | 0.987654 | ++------------+------------+------------+------------+ +| HGNC:9 | 0.456788 | 0.876543 | 0.876542 | ++------------+------------+------------+------------+ +| HGNC:23 | 0.876543 | 0.786543 | 0.897654 | ++------------+------------+------------+------------+ + +| + +Class-file: + ++------------+------------+ +| Patient_ID | class | ++============+============+ +| TCGAAA3529 | MSI | ++------------+------------+ +| TCGAA62671 | MSS | ++------------+------------+ +| TCGAA62672 | MSI | ++------------+------------+ + +| + + + +.. class:: warningmark + +This tool expects input datasets consisting of tab-delimited columns. + + +.. class:: infomark + +TIP: If your data is not TAB delimited, use `Convert delimiters to TAB`_. + +.. class:: infomark + +TIP: If your dataset is not split into classes, use `Cluster for MaREA`_. + +This tool is developed by the `nome del gruppo di bioinformatica`_ at the `dipartimento di informatica disco`_. + + +.. _Convert delimiters to TAB: https://usegalaxy.org/?tool_id=Convert+characters1&version=1.0.0&__identifer=6t22teyofhj +.. _Cluster for MaREA: http://link del tool di cluster.org/ +.. _nome del gruppo di bioinformatica: http://sito di bio.org +.. _dipartimento di informatica disco : http://www.disco.unimib.it/go/Home/English + +]]> + </help> +</tool> + + + + + + + + + + + + +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/Marea/marea_cluster.py Tue Nov 06 03:16:21 2018 -0500 @@ -0,0 +1,608 @@ + +from __future__ import division +import os +import sys +import pandas as pd +import collections +import pickle as pk +import argparse +from sklearn.cluster import KMeans +import matplotlib.pyplot as plt + +########################## argparse ########################################### + +def process_args(args): + parser = argparse.ArgumentParser(usage = '%(prog)s [options]', + description = 'process some value\'s' + + ' genes to create class.') + parser.add_argument('-rs', '--rules_selector', + type = str, + default = 'HMRcore', + choices = ['HMRcore', 'Recon', 'Custom'], + help = 'chose which type of dataset you want use') + parser.add_argument('-cr', '--custom', + type = str, + help='your dataset if you want custom rules') + parser.add_argument('-ch', '--cond_hier', + type = str, + default = 'no', + choices = ['no', 'yes'], + help = 'chose if you wanna hierical dendrogram') + parser.add_argument('-lk', '--k_min', + type = int, + help = 'min number of cluster') + parser.add_argument('-uk', '--k_max', + type = int, + help = 'max number of cluster') + parser.add_argument('-li', '--linkage', + type = str, + choices = ['single', 'complete', 'average'], + help='linkage hierarchical cluster') + parser.add_argument('-d', '--data', + type = str, + required = True, + help = 'input dataset') + parser.add_argument('-n', '--none', + type = str, + default = 'true', + choices = ['true', 'false'], + help = 'compute Nan values') + parser.add_argument('-td', '--tool_dir', + type = str, + required = True, + help = 'your tool directory') + parser.add_argument('-na', '--name', + type = str, + help = 'name of dataset') + parser.add_argument('-de', '--dendro', + help = "Dendrogram out") + parser.add_argument('-ol', '--out_log', + help = "Output log") + parser.add_argument('-el', '--elbow', + help = "Out elbow") + args = parser.parse_args() + return args + +########################### warning ########################################### + +def warning(s): + args = process_args(sys.argv) + with open(args.out_log, 'a') as log: + log.write(s) + +############################ dataset input #################################### + +def read_dataset(data, name): + try: + dataset = pd.read_csv(data, sep = '\t', header = 0) + except pd.errors.EmptyDataError: + sys.exit('Execution aborted: wrong format of '+name+'\n') + if len(dataset.columns) < 2: + sys.exit('Execution aborted: wrong format of '+name+'\n') + return dataset + +############################ dataset name ##################################### + +def name_dataset(name_data, count): + if str(name_data) == 'Dataset': + return str(name_data) + '_' + str(count) + else: + return str(name_data) + +############################ load id e rules ################################## + +def load_id_rules(reactions): + ids, rules = [], [] + for key, value in reactions.items(): + ids.append(key) + rules.append(value) + return (ids, rules) + +############################ check_methods #################################### + +def gene_type(l, name): + if check_hgnc(l): + return 'hugo_id' + elif check_ensembl(l): + return 'ensembl_gene_id' + elif check_symbol(l): + return 'symbol' + elif check_entrez(l): + return 'entrez_id' + else: + sys.exit('Execution aborted:\n' + + 'gene ID type in ' + name + ' not supported. Supported ID' + + 'types are: HUGO ID, Ensemble ID, HUGO symbol, Entrez ID\n') + +def check_hgnc(l): + if len(l) > 5: + if (l.upper()).startswith('HGNC:'): + return l[5:].isdigit() + else: + return False + else: + return False + +def check_ensembl(l): + if len(l) == 15: + if (l.upper()).startswith('ENS'): + return l[4:].isdigit() + else: + return False + else: + return False + +def check_symbol(l): + if len(l) > 0: + if l[0].isalpha() and l[1:].isalnum(): + return True + else: + return False + else: + return False + +def check_entrez(l): + if len(l) > 0: + return l.isdigit() + else: + return False + +def check_bool(b): + if b == 'true': + return True + elif b == 'false': + return False + +############################ make recon ####################################### + +def check_and_doWord(l): + tmp = [] + tmp_genes = [] + count = 0 + while l: + if count >= 0: + if l[0] == '(': + count += 1 + tmp.append(l[0]) + l.pop(0) + elif l[0] == ')': + count -= 1 + tmp.append(l[0]) + l.pop(0) + elif l[0] == ' ': + l.pop(0) + else: + word = [] + while l: + if l[0] in [' ', '(', ')']: + break + else: + word.append(l[0]) + l.pop(0) + word = ''.join(word) + tmp.append(word) + if not(word in ['or', 'and']): + tmp_genes.append(word) + else: + return False + if count == 0: + return (tmp, tmp_genes) + else: + return False + +def brackets_to_list(l): + tmp = [] + while l: + if l[0] == '(': + l.pop(0) + tmp.append(resolve_brackets(l)) + else: + tmp.append(l[0]) + l.pop(0) + return tmp + +def resolve_brackets(l): + tmp = [] + while l[0] != ')': + if l[0] == '(': + l.pop(0) + tmp.append(resolve_brackets(l)) + else: + tmp.append(l[0]) + l.pop(0) + l.pop(0) + return tmp + +def priorityAND(l): + tmp = [] + flag = True + while l: + if len(l) == 1: + if isinstance(l[0], list): + tmp.append(priorityAND(l[0])) + else: + tmp.append(l[0]) + l = l[1:] + elif l[0] == 'or': + tmp.append(l[0]) + flag = False + l = l[1:] + elif l[1] == 'or': + if isinstance(l[0], list): + tmp.append(priorityAND(l[0])) + else: + tmp.append(l[0]) + tmp.append(l[1]) + flag = False + l = l[2:] + elif l[1] == 'and': + tmpAnd = [] + if isinstance(l[0], list): + tmpAnd.append(priorityAND(l[0])) + else: + tmpAnd.append(l[0]) + tmpAnd.append(l[1]) + if isinstance(l[2], list): + tmpAnd.append(priorityAND(l[2])) + else: + tmpAnd.append(l[2]) + l = l[3:] + while l: + if l[0] == 'and': + tmpAnd.append(l[0]) + if isinstance(l[1], list): + tmpAnd.append(priorityAND(l[1])) + else: + tmpAnd.append(l[1]) + l = l[2:] + elif l[0] == 'or': + flag = False + break + if flag == True: #se ci sono solo AND nella lista + tmp.extend(tmpAnd) + elif flag == False: + tmp.append(tmpAnd) + return tmp + +def checkRule(l): + if len(l) == 1: + if isinstance(l[0], list): + if checkRule(l[0]) is False: + return False + elif len(l) > 2: + if checkRule2(l) is False: + return False + else: + return False + return True + +def checkRule2(l): + while l: + if len(l) == 1: + return False + elif isinstance(l[0], list) and l[1] in ['and', 'or']: + if checkRule(l[0]) is False: + return False + if isinstance(l[2], list): + if checkRule(l[2]) is False: + return False + l = l[3:] + elif l[1] in ['and', 'or']: + if isinstance(l[2], list): + if checkRule(l[2]) is False: + return False + l = l[3:] + elif l[0] in ['and', 'or']: + if isinstance(l[1], list): + if checkRule(l[1]) is False: + return False + l = l[2:] + else: + return False + return True + +def do_rules(rules): + split_rules = [] + err_rules = [] + tmp_gene_in_rule = [] + for i in range(len(rules)): + tmp = list(rules[i]) + if tmp: + tmp, tmp_genes = check_and_doWord(tmp) + tmp_gene_in_rule.extend(tmp_genes) + if tmp is False: + split_rules.append([]) + err_rules.append(rules[i]) + else: + tmp = brackets_to_list(tmp) + if checkRule(tmp): + split_rules.append(priorityAND(tmp)) + else: + split_rules.append([]) + err_rules.append(rules[i]) + else: + split_rules.append([]) + if err_rules: + warning('Warning: wrong format rule in ' + str(err_rules) + '\n') + return (split_rules, list(set(tmp_gene_in_rule))) + +def make_recon(data): + try: + import cobra as cb + import warnings + with warnings.catch_warnings(): + warnings.simplefilter('ignore') + recon = cb.io.read_sbml_model(data) + react = recon.reactions + rules = [react[i].gene_reaction_rule for i in range(len(react))] + ids = [react[i].id for i in range(len(react))] + except cb.io.sbml3.CobraSBMLError: + try: + data = (pd.read_csv(data, sep = '\t', dtype = str)).fillna('') + if len(data.columns) < 2: + sys.exit('Execution aborted: wrong format of ' + + 'custom GPR rules\n') + if not len(data.columns) == 2: + warning('WARNING: more than 2 columns in custom GPR rules.\n' + + 'Extra columns have been disregarded\n') + ids = list(data.iloc[:, 0]) + rules = list(data.iloc[:, 1]) + except pd.errors.EmptyDataError: + sys.exit('Execution aborted: wrong format of custom GPR rules\n') + except pd.errors.ParserError: + sys.exit('Execution aborted: wrong format of custom GPR rules\n') + split_rules, tmp_genes = do_rules(rules) + gene_in_rule = {} + for i in tmp_genes: + gene_in_rule[i] = 'ok' + return (ids, split_rules, gene_in_rule) + +############################ resolve_methods ################################## + +def replace_gene_value(l, d): + tmp = [] + err = [] + while l: + if isinstance(l[0], list): + tmp_rules, tmp_err = replace_gene_value(l[0], d) + tmp.append(tmp_rules) + err.extend(tmp_err) + else: + value = replace_gene(l[0],d) + tmp.append(value) + if value == None: + err.append(l[0]) + l = l[1:] + return (tmp, err) + +def replace_gene(l, d): + if l =='and' or l == 'or': + return l + else: + value = d.get(l, None) + if not(value == None or isinstance(value, (int, float))): + sys.exit('Execution aborted: ' + value + ' value not valid\n') + return value + +def compute(val1, op, val2, cn): + if val1 != None and val2 != None: + if op == 'and': + return min(val1, val2) + else: + return val1 + val2 + elif op == 'and': + if cn is True: + if val1 != None: + return val1 + elif val2 != None: + return val2 + else: + return None + else: + return None + else: + if val1 != None: + return val1 + elif val2 != None: + return val2 + else: + return None + +def control(ris, l, cn): + if len(l) == 1: + if isinstance(l[0], (float, int)) or l[0] == None: + return l[0] + elif isinstance(l[0], list): + return control(None, l[0], cn) + else: + return False + elif len(l) > 2: + return control_list(ris, l, cn) + else: + return False + +def control_list(ris, l, cn): + while l: + if len(l) == 1: + return False + elif (isinstance(l[0], (float, int)) or + l[0] == None) and l[1] in ['and', 'or']: + if isinstance(l[2], (float, int)) or l[2] == None: + ris = compute(l[0], l[1], l[2], cn) + elif isinstance(l[2], list): + tmp = control(None, l[2], cn) + if tmp is False: + return False + else: + ris = compute(l[0], l[1], tmp, cn) + else: + return False + l = l[3:] + elif l[0] in ['and', 'or']: + if isinstance(l[1], (float, int)) or l[1] == None: + ris = compute(ris, l[0], l[1], cn) + elif isinstance(l[1], list): + tmp = control(None,l[1], cn) + if tmp is False: + return False + else: + ris = compute(ris, l[0], tmp, cn) + else: + return False + l = l[2:] + elif isinstance(l[0], list) and l[1] in ['and', 'or']: + if isinstance(l[2], (float, int)) or l[2] == None: + tmp = control(None, l[0], cn) + if tmp is False: + return False + else: + ris = compute(tmp, l[1], l[2], cn) + elif isinstance(l[2], list): + tmp = control(None, l[0], cn) + tmp2 = control(None, l[2], cn) + if tmp is False or tmp2 is False: + return False + else: + ris = compute(tmp, l[1], tmp2, cn) + else: + return False + l = l[3:] + else: + return False + return ris + +############################ gene ############################################# + +def data_gene(gene, type_gene, name, gene_custom): + args = process_args(sys.argv) + for i in range(len(gene)): + tmp = gene.iloc[i, 0] + if tmp.startswith(' ') or tmp.endswith(' '): + gene.iloc[i, 0] = (tmp.lstrip()).rstrip() + gene_dup = [item for item, count in + collections.Counter(gene[gene.columns[0]]).items() if count > 1] + pat_dup = [item for item, count in + collections.Counter(list(gene.columns)).items() if count > 1] + if gene_dup: + if gene_custom == None: + if args.rules_selector == 'HMRcore': + gene_in_rule = pk.load(open(args.tool_dir + + '/local/HMRcore_genes.p', 'rb')) + elif args.rules_selector == 'Recon': + gene_in_rule = pk.load(open(args.tool_dir + + '/local/Recon_genes.p', 'rb')) + gene_in_rule = gene_in_rule.get(type_gene) + else: + gene_in_rule = gene_custom + tmp = [] + for i in gene_dup: + if gene_in_rule.get(i) == 'ok': + tmp.append(i) + if tmp: + sys.exit('Execution aborted because gene ID ' + + str(tmp) + ' in ' + name + ' is duplicated\n') + if pat_dup: + sys.exit('Execution aborted: duplicated label\n' + + str(pat_dup) + 'in ' + name + '\n') + return (gene.set_index(gene.columns[0])).to_dict() + +############################ resolve ########################################## + +def resolve(genes, rules, ids, resolve_none, name): + resolve_rules = {} + not_found = [] + flag = False + for key, value in genes.items(): + tmp_resolve = [] + for i in range(len(rules)): + tmp = rules[i] + if tmp: + tmp, err = replace_gene_value(tmp, value) + if err: + not_found.extend(err) + ris = control(None, tmp, resolve_none) + if ris is False or ris == None: + tmp_resolve.append(None) + else: + tmp_resolve.append(ris) + flag = True + else: + tmp_resolve.append(None) + resolve_rules[key] = tmp_resolve + if flag is False: + sys.exit('Execution aborted: no computable score' + + ' (due to missing gene values) for class ' + + name + ', the class has been disregarded\n') + return (resolve_rules, list(set(not_found))) + +################################# clustering ################################## + +def f_cluster(resolve_rules): + os.makedirs('cluster_out') + args = process_args(sys.argv) + cluster_data = pd.DataFrame.from_dict(resolve_rules, orient = 'index') + for i in cluster_data.columns: + tmp = cluster_data[i][0] + if tmp == None: + cluster_data = cluster_data.drop(columns=[i]) + distorsion = [] + for i in range(args.k_min, args.k_max+1): + tmp_kmeans = KMeans(n_clusters = i, + n_init = 100, + max_iter = 300, + random_state = 0).fit(cluster_data) + distorsion.append(tmp_kmeans.inertia_) + predict = tmp_kmeans.predict(cluster_data) + predict = [x+1 for x in predict] + classe = (pd.DataFrame(zip(cluster_data.index, predict))).astype(str) + dest = 'cluster_out/K=' + str(i) + '_' + args.name+'.tsv' + classe.to_csv(dest, sep = '\t', index = False, + header = ['Patient_ID', 'Class']) + plt.figure(0) + plt.plot(range(args.k_min, args.k_max+1), distorsion, marker = 'o') + plt.xlabel('Number of cluster') + plt.ylabel('Distorsion') + plt.savefig(args.elbow, dpi = 240, format = 'pdf') + if args.cond_hier == 'yes': + import scipy.cluster.hierarchy as hier + lin = hier.linkage(cluster_data, args.linkage) + plt.figure(1) + plt.figure(figsize=(10, 5)) + hier.dendrogram(lin, leaf_font_size = 2, labels = cluster_data.index) + plt.savefig(args.dendro, dpi = 480, format = 'pdf') + return None + +################################# main ######################################## + +def main(): + args = process_args(sys.argv) + if args.k_min > args.k_max: + sys.exit('Execution aborted: max cluster > min cluster') + if args.rules_selector == 'HMRcore': + recon = pk.load(open(args.tool_dir + '/local/HMRcore_rules.p', 'rb')) + elif args.rules_selector == 'Recon': + recon = pk.load(open(args.tool_dir + '/local/Recon_rules.p', 'rb')) + elif args.rules_selector == 'Custom': + ids, rules, gene_in_rule = make_recon(args.custom) + resolve_none = check_bool(args.none) + dataset = read_dataset(args.data, args.name) + dataset.iloc[:, 0] = (dataset.iloc[:, 0]).astype(str) + type_gene = gene_type(dataset.iloc[0, 0], args.name) + if args.rules_selector != 'Custom': + genes = data_gene(dataset, type_gene, args.name, None) + ids, rules = load_id_rules(recon.get(type_gene)) + elif args.rules_selector == 'Custom': + genes = data_gene(dataset, type_gene, args.name, gene_in_rule) + resolve_rules, err = resolve(genes, rules, ids, resolve_none, args.name) + if err: + warning('WARNING: gene\n' + str(err) + '\nnot found in class ' + + args.name + ', the expression level for this gene ' + + 'will be considered NaN\n') + f_cluster(resolve_rules) + warning('Execution succeeded') + return None + +############################################################################### + +if __name__ == "__main__": + main() \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/Marea/marea_cluster.xml Tue Nov 06 03:16:21 2018 -0500 @@ -0,0 +1,97 @@ +<tool id="MaREA_cluester" name="MaREA cluster analysis"> + <description>of Reaction Activity Scores</description> + <requirements> + <requirement type="package">pandas</requirement> + <requirement type="package">scikit-learn</requirement> + <requirement type="package">scipy</requirement> + <requirement type="package">matplotlib</requirement> + <requirement type="package">cobrapy</requirement> + <requirement type="package">python-libsbml</requirement> + </requirements> + <command> + <![CDATA[ + python $__tool_directory__/marea_cluster.py + --rules_selector $cond_rule.rules_selector + #if $cond_rule.rules_selector == 'Custom': + --custom ${cond_rule.Custom_rules} + #end if + --cond_hier $cond_hier.hier + #if $cond_hier.hier == 'yes': + --linkage ${cond_hier.linkage} + --dendro $dendrogram + #end if + --k_max $k_max + --k_min $k_min + --data $input + --name $name + --none $None + --tool_dir $__tool_directory__ + --out_log $log + --elbow $elbow + ]]> + </command> + <inputs> + <conditional name="cond_rule"> + <param name="rules_selector" type="select" label="Gene-Protein-Reaction rules:"> + <option value="HMRcore" selected="true">HMRcore rules</option> + <option value="Recon">Recon 2.2 rules</option> + <option value="Custom">Custom rules</option> + </param> + <when value="Custom"> + <param name="Custom_rules" type="data" format="tabular, csv, tsv, xml" label="Custom rules"/> + </when> + </conditional> + <param name="input" type="data" format="tabular, csv, tsv" label="RNAseq of all samples"/> + <param name="name" type="text" label="Output name prefix" value = "dataset"/> + <param name="k_min" type="integer" size="20" value="3" min="2" max="30" label="min number of clusters (k) to be tested (k-means)"/> + <param name="k_max" type="integer" size="20" value="3" min="2" max="30" label="max number of clusters (k) to be tested (k-means)"/> + <param name="None" type="boolean" truevalue="true" falsevalue="false" checked="true" label="(A and NaN) solved as (A)?" help="if NO is selected (A and NaN) is solved as (NaN)"/> + <conditional name="cond_hier"> + <param name="hier" type="select" label="Produce dendrogram (hierarchical clustering):"> + <option value="no" selected="true">no</option> + <option value="yes">yes</option> + </param> + <when value="yes"> + <param name="linkage" type="select" label="Linkage type:"> + <option value="single" selected="true">Single: minimum distance between all observations of two sets</option> + <option value="complete">Complete: maximum distance between all observations of two sets</option> + <option value="average">Average: average distance between all observations of two sets</option> + </param> + </when> + </conditional> + </inputs> + <outputs> + <data format="txt" name="log" label="Log"/> + <data format="pdf" name="dendrogram" label="$name dendrogram"> + <filter>cond_hier['hier'] == 'yes'</filter> + </data> + <data format="pdf" name="elbow" label="$name elbow evaluation method"/> + <collection name="cluster_out" type="list" label="Clusters $k_min - $k_max"> + <discover_datasets pattern="__name_and_ext__" directory="cluster_out"/> + </collection> + </outputs> + <help> + +.. class:: warningmark + +This tool expects input datasets consisting of tab-delimited columns. + +.. class:: infomark + +**TIP:** If your data is not TAB delimited, use *Text Manipulation > Convert delimiters to TAB* + + </help> +</tool> + + + + + + + + + + + + +