Mercurial > repos > computationaltranscriptomics > vgx_converter
view test-data/Apoptosis.sif @ 16:567274fa974d draft
Uploaded
| author | computationaltranscriptomics |
|---|---|
| date | Sat, 04 Jun 2016 03:22:52 -0400 |
| parents | |
| children |
line wrap: on
line source
p(HGNC:FOXO3,pmod(P,S,253)) directlyDecreases tscript(p(HGNC:FOXO3)) p(HGNC:FLOT2) decreases p(HGNC:FAS) p(HGNC:FLOT2) increases p(HGNC:XIAP) p(HGNC:FLOT2) increases p(HGNC:BIRC5) p(HGNC:FLOT2) decreases cat(p(HGNC:CASP8)) p(HGNC:FLOT2) decreases cat(p(HGNC:CASP3)) p(HGNC:PDGFA) increases p(HGNC:FOXO3,pmod(P,S,253)) p(HGNC:IL6) increases p(HGNC:BAX) p(HGNC:IL6) increases p(HGNC:STAT3) p(HGNC:SIRT1) increases p(HGNC:RELA,pmod(A)) p(HGNC:SIRT1) association p(HGNC:PARP1) p(HGNC:XRCC6) decreases cat(p(HGNC:BAX)) p(HGNC:STAT3) decreases cat(p(HGNC:CASP7)) p(HGNC:STAT3) decreases cat(p(HGNC:CASP3)) p(SFAM:"FOXO Family") actsIn tscript(p(SFAM:"FOXO Family")) cat(p(HGNC:CASP10)) increases cat(p(HGNC:CASP3)) p(HGNC:FOXO1,pmod(P,S,256)) directlyDecreases tscript(p(HGNC:FOXO1)) complex(p(HGNC:APAF1),p(HGNC:CYCS),p(HGNC:CASP9)) hasComponent p(HGNC:CYCS) complex(p(HGNC:APAF1),p(HGNC:CYCS),p(HGNC:CASP9)) hasComponent p(HGNC:APAF1) complex(p(HGNC:APAF1),p(HGNC:CYCS),p(HGNC:CASP9)) hasComponent p(HGNC:CASP9) complex(p(HGNC:APAF1),p(HGNC:CYCS),p(HGNC:CASP9)) increases cat(p(HGNC:CASP9)) p(SFAM:"PRKA Family") actsIn kin(p(SFAM:"PRKA Family")) p(HGNC:MARCKS) hasModification p(HGNC:MARCKS,pmod(P,S,163)) cat(p(HGNC:CASP7)) directlyDecreases p(HGNC:PARP1) tscript(complex(SCOMP:"Nfkb Complex")) directlyIncreases p(HGNC:BCL2) tscript(complex(SCOMP:"Nfkb Complex")) increases p(HGNC:BIRC2) tscript(complex(SCOMP:"Nfkb Complex")) increases p(HGNC:BIRC3) tscript(complex(SCOMP:"Nfkb Complex")) directlyIncreases p(HGNC:BCL2L1) tscript(complex(SCOMP:"Nfkb Complex")) directlyIncreases p(HGNC:XIAP) tscript(complex(SCOMP:"Nfkb Complex")) increases p(HGNC:CFLAR) tscript(complex(SCOMP:"Nfkb Complex")) increases p(HGNC:BCL2A1) tscript(complex(SCOMP:"Nfkb Complex")) increases p(HGNC:BIRC5) tscript(p(HGNC:XBP1)) increases bp(GOBP:"ER-associated ubiquitin-dependent protein catabolic process") p(HGNC:FAS) actsIn cat(p(HGNC:FAS)) kin(p(HGNC:PRKCA)) directlyIncreases p(HGNC:PRKD1,pmod(P,S,742)) kin(p(HGNC:PRKCA)) directlyIncreases p(HGNC:PRKCA,pmod(P,T,638)) kin(p(HGNC:PRKCA)) directlyIncreases p(HGNC:PRKD1,pmod(P,S,738)) kin(p(HGNC:PRKCA)) directlyIncreases p(HGNC:MARCKS,pmod(P,S,159)) cat(p(HGNC:ERN1)) directlyIncreases p(HGNC:XBP1) p(HGNC:PRKCD) actsIn kin(p(HGNC:PRKCD)) p(HGNC:MAP2K7) actsIn kin(p(HGNC:MAP2K7)) p(HGNC:MAPK1) actsIn kin(p(HGNC:MAPK1)) cat(p(HGNC:CASP3)) directlyDecreases cat(p(HGNC:BCL2)) cat(p(HGNC:CASP3)) directlyIncreases cat(p(HGNC:ACIN1)) cat(p(HGNC:CASP3)) increases kin(p(HGNC:ROCK1)) cat(p(HGNC:CASP3)) directlyIncreases deg(p(HGNC:LMNB2)) cat(p(HGNC:CASP3)) increases bp(MESHPP:Apoptosis) cat(p(HGNC:CASP3)) increases cat(p(HGNC:CASP7)) cat(p(HGNC:CASP3)) directlyIncreases cat(p(HGNC:GAS2)) cat(p(HGNC:CASP3)) increases deg(p(HGNC:LMNA)) cat(p(HGNC:CASP3)) directlyDecreases cat(p(HGNC:DFFA)) cat(p(HGNC:CASP3)) directlyIncreases kin(p(HGNC:BMX)) cat(p(HGNC:CASP3)) directlyIncreases cat(p(HGNC:CASP2)) cat(p(HGNC:CASP3)) directlyIncreases deg(p(HGNC:LMNB1)) cat(p(HGNC:CASP3)) directlyDecreases cat(p(HGNC:BCL2L1)) cat(p(HGNC:CASP3)) increases path(MESHD:Emphysema) cat(p(HGNC:CASP3)) directlyIncreases kin(p(HGNC:PAK2)) cat(p(HGNC:CASP3)) decreases p(HGNC:PARP1) p(HGNC:IKBKB) hasModification p(HGNC:IKBKB,pmod(P,S,177)) cat(p(HGNC:TNFRSF10B)) increases cat(p(HGNC:TRAF2)) p(HGNC:MAP3K7) hasModification p(HGNC:MAP3K7,pmod(U,K,158)) p(HGNC:ACIN1) actsIn cat(p(HGNC:ACIN1)) p(HGNC:XIAP) decreases bp(MESHPP:Apoptosis) p(HGNC:XIAP) actsIn cat(p(HGNC:XIAP)) p(HGNC:NFKBIA,pmod(P,S,36)) directlyIncreases deg(p(HGNC:NFKBIA)) kin(p(HGNC:CHUK)) decreases p(HGNC:NFKBIE) complex(p(HGNC:RIPK1),p(HGNC:TNFRSF10A)) hasComponent p(HGNC:TNFRSF10A) complex(p(HGNC:RIPK1),p(HGNC:TNFRSF10A)) hasComponent p(HGNC:RIPK1) p(HGNC:PPP1R15A) increases bp(GOBP:"cell death") p(HGNC:TNFRSF10B) actsIn cat(p(HGNC:TNFRSF10B)) complex(SCOMP:"Nfkb Complex") hasComponent p(HGNC:NFKB2) kin(p(SFAM:"PIK3C Class IA Family")) increases kin(p(HGNC:MAPK1)) kin(p(SFAM:"PIK3C Class IA Family")) increases p(HGNC:AKT1,pmod(P,T,308)) kin(p(SFAM:"PIK3C Class IA Family")) increases p(HGNC:AKT1,pmod(P,S,473)) kin(p(SFAM:"PIK3C Class IA Family")) increases kin(p(SFAM:"AKT Family")) kin(p(SFAM:"PIK3C Class IA Family")) directlyIncreases a(SCHEM:"Phosphatidylinositol-3,4,5-trisphosphate") kin(p(SFAM:"PIK3C Class IA Family")) increases kin(p(HGNC:MAPK3)) cat(p(HGNC:DIABLO)) decreases cat(p(HGNC:XIAP)) complex(SCOMP:"Nfkb Complex") actsIn tscript(complex(SCOMP:"Nfkb Complex")) complex(SCOMP:"Nfkb Complex") hasComponent p(HGNC:NFKB1) complex(SCOMP:"Nfkb Complex") hasComponent p(HGNC:REL) complex(SCOMP:"Nfkb Complex") hasComponent p(HGNC:RELB) p(HGNC:FOXO3) hasModification p(HGNC:FOXO3,pmod(P,S,253)) p(HGNC:FOXO3) actsIn tscript(p(HGNC:FOXO3)) p(HGNC:MAP3K1,pmod(P,S,994)) directlyIncreases kin(p(HGNC:MAP3K1)) kin(p(HGNC:PAK2)) increases bp(MESHPP:Apoptosis) p(HGNC:DIABLO) actsIn cat(p(HGNC:DIABLO)) cat(p(HGNC:BAK1)) increases tport(complex(GOCC:"mitochondrial permeability transition pore complex")) p(HGNC:IKBKB) actsIn kin(p(HGNC:IKBKB)) cat(p(HGNC:TNFRSF1B)) increases cat(p(HGNC:TRAF2)) cat(p(HGNC:TRAF2)) increases kin(p(HGNC:MAP3K5)) cat(p(HGNC:TRAF2)) increases p(HGNC:MAP3K7,pmod(U,K,158)) cat(p(HGNC:TRAF2)) directlyIncreases kin(p(HGNC:MAP3K7)) cat(p(HGNC:TRAF2)) increases kin(p(HGNC:MAP3K14)) cat(p(HGNC:BAD)) increases bp(MESHPP:Apoptosis) cat(p(HGNC:BAD)) increases cat(p(HGNC:BAX)) cat(p(HGNC:BAD)) increases cat(p(HGNC:BAK1)) p(HGNC:ATF4) actsIn tscript(p(HGNC:ATF4)) kin(p(HGNC:PRKCE)) directlyIncreases p(HGNC:ELK1,pmod(P,S,383)) kin(p(HGNC:ROCK1)) increases bp(MESHPP:Apoptosis) p(HGNC:RPS6KA1) actsIn kin(p(HGNC:RPS6KA1)) bp(GOBP:"response to endoplasmic reticulum stress") increases bp(GOBP:"response to unfolded protein") bp(GOBP:"response to endoplasmic reticulum stress") increases kin(p(HGNC:EIF2AK3)) p(HGNC:PCNA) decreases bp(MESHPP:Apoptosis) p(HGNC:PDPK1) actsIn kin(p(HGNC:PDPK1)) p(HGNC:PRKCZ) actsIn kin(p(HGNC:PRKCZ)) kin(p(SFAM:"PRKC Family")) directlyIncreases p(HGNC:MARCKS,pmod(P,S,163)) p(HGNC:TRAF2) actsIn cat(p(HGNC:TRAF2)) bp(GOBP:"response to unfolded protein") increases cat(p(HGNC:ERN1)) bp(GOBP:"response to unfolded protein") directlyDecreases complex(p(HGNC:HSPA5),p(HGNC:ERN1)) bp(GOBP:"response to unfolded protein") directlyDecreases complex(p(HGNC:HSPA5),p(HGNC:EIF2AK3)) p(HGNC:MAP3K14) actsIn kin(p(HGNC:MAP3K14)) p(HGNC:DFFA) actsIn cat(p(HGNC:DFFA)) cat(p(HGNC:BBC3)) increases cat(p(HGNC:BAK1)) cat(p(HGNC:BBC3)) directlyIncreases cat(p(HGNC:BAX)) p(HGNC:EIF2AK3) actsIn kin(p(HGNC:EIF2AK3)) p(HGNC:ENDOG) increases bp(MESHPP:Apoptosis) p(HGNC:BAX,pmod(P,S,184)) directlyDecreases cat(p(HGNC:BAX)) p(HGNC:HTRA2) increases bp(MESHPP:Apoptosis) p(HGNC:HTRA2) actsIn cat(p(HGNC:HTRA2)) p(HGNC:BMX) actsIn kin(p(HGNC:BMX)) p(HGNC:PTEN) actsIn phos(p(HGNC:PTEN)) p(HGNC:NFKBIA) actsIn kin(p(HGNC:NFKBIA)) tport(complex(GOCC:"mitochondrial permeability transition pore complex")) increases bp(MESHPP:Apoptosis) p(HGNC:MAP3K5) actsIn kin(p(HGNC:MAP3K5)) p(HGNC:TP53) actsIn tscript(p(HGNC:TP53)) kin(p(HGNC:MAPK3)) decreases cat(p(HGNC:BAD)) kin(p(HGNC:MAPK3)) directlyIncreases p(HGNC:BCL2L11,pmod(P,S,69)) kin(p(HGNC:MAPK3)) directlyIncreases p(HGNC:CASP9,pmod(P,T,125)) kin(p(HGNC:PRKCD)) increases p(HGNC:BAX) kin(p(HGNC:PRKCD)) directlyIncreases p(HGNC:PRKD1,pmod(P,S,742)) kin(p(HGNC:PRKCD)) directlyIncreases p(HGNC:PRKD1,pmod(P,S,738)) p(HGNC:PTEN,pmod(P,T,383)) directlyDecreases phos(p(HGNC:PTEN)) p(HGNC:AIFM1) increases bp(MESHPP:Apoptosis) p(HGNC:RELA) hasModification p(HGNC:RELA,pmod(A)) p(HGNC:RELA) hasComponent complex(SCOMP:"Nfkb Complex") p(HGNC:ERN1) actsIn cat(p(HGNC:ERN1)) cat(p(HGNC:CASP9)) directlyIncreases cat(p(HGNC:CASP3)) cat(p(HGNC:CASP9)) directlyIncreases cat(p(HGNC:CASP7)) cat(p(HGNC:CASP9)) directlyIncreases cat(p(HGNC:CASP6)) tscript(p(HGNC:FOXO1)) isA tscript(p(SFAM:"FOXO Family")) tscript(p(HGNC:FOXO3)) isA tscript(p(SFAM:"FOXO Family")) p(HGNC:BCL2L11) actsIn cat(p(HGNC:BCL2L11)) p(HGNC:BCL2L11) increases bp(MESHPP:Apoptosis) cat(p(HGNC:FADD)) increases cat(p(HGNC:CASP10)) cat(p(HGNC:FADD)) directlyIncreases cat(p(HGNC:CASP8)) cat(p(HGNC:BCL2)) directlyDecreases cat(p(HGNC:BAX)) cat(p(HGNC:BCL2)) decreases bp(MESHPP:Apoptosis) cat(p(HGNC:BCL2)) decreases cat(p(HGNC:BAK1)) cat(p(HGNC:BCL2L11)) directlyIncreases cat(p(HGNC:BAX)) cat(p(HGNC:BCL2L11)) directlyIncreases cat(p(HGNC:BAK1)) cat(p(HGNC:BCL2L11)) increases bp(MESHPP:Apoptosis) kin(p(HGNC:AKT2)) directlyDecreases kin(p(HGNC:MAP3K5)) p(HGNC:BAD,pmod(P,S,75)) directlyDecreases cat(p(HGNC:BAD)) p(HGNC:PRKCD,pmod(P,T,505)) directlyIncreases kin(p(HGNC:PRKCD)) p(HGNC:PRKCD) hasModification p(HGNC:PRKCD,pmod(P,T,505)) p(HGNC:MAPK3) actsIn kin(p(HGNC:MAPK3)) p(HGNC:BIRC3) decreases bp(MESHPP:Apoptosis) a(SCHEM:"Smoke, cigarette") increases p(HGNC:PPP1R15A) kin(p(HGNC:MAPK1)) directlyIncreases p(HGNC:BCL2L11,pmod(P,S,69)) kin(p(HGNC:MAPK1)) decreases cat(p(HGNC:BAD)) kin(p(HGNC:MAPK1)) directlyIncreases p(HGNC:CASP9,pmod(P,T,125)) cat(p(HGNC:CASP2)) increases bp(MESHPP:Apoptosis) p(HGNC:GAS2) positiveCorrelation bp(MESHPP:Apoptosis) p(HGNC:GAS2) actsIn cat(p(HGNC:GAS2)) p(HGNC:TNFSF10) increases cat(p(HGNC:TNFRSF10A)) p(HGNC:TNFSF10) increases cat(p(HGNC:TNFRSF10B)) p(HGNC:TNFSF10) increases complex(p(HGNC:RIPK1),p(HGNC:TNFRSF10A)) p(HGNC:PRKCZ) hasModification p(HGNC:PRKCZ,pmod(P,T,410)) p(HGNC:PRKCZ,pmod(P,T,410)) directlyIncreases kin(p(HGNC:PRKCZ)) p(HGNC:CYCS) increases bp(MESHPP:Apoptosis) bp(MESHPP:Apoptosis) isA bp(GOBP:"cell death") kin(p(HGNC:EIF2AK3)) directlyIncreases p(HGNC:EIF2S1,pmod(P,S,52)) cat(p(HGNC:BAX)) increases bp(MESHPP:Apoptosis) cat(p(HGNC:BAX)) increases tport(complex(GOCC:"mitochondrial permeability transition pore complex")) p(HGNC:MCL1) actsIn cat(p(HGNC:MCL1)) cat(p(HGNC:TNFRSF1A)) increases cat(p(HGNC:TRADD)) cat(p(HGNC:TNFRSF1A)) increases cat(p(HGNC:TRAF2)) cat(p(HGNC:BCL2L1)) decreases bp(MESHPP:Apoptosis) cat(p(HGNC:BCL2L1)) directlyDecreases cat(p(HGNC:BAX)) cat(p(HGNC:BCL2L1)) directlyDecreases cat(p(HGNC:BAK1)) p(HGNC:EP300) actsIn tscript(p(HGNC:EP300)) a(SCHEM:Leptin) decreases bp(MESHPP:Apoptosis) p(HGNC:CHUK) hasModification p(HGNC:CHUK,pmod(P,S,176)) kin(p(HGNC:MAP3K14)) increases kin(complex(SCOMP:"IkappaB Kinase Complex")) kin(p(HGNC:MAP3K14)) directlyIncreases p(HGNC:CHUK,pmod(P,S,176)) p(HGNC:PRKCA) hasModification p(HGNC:PRKCA,pmod(P,T,638)) complex(p(HGNC:HSPA5),p(HGNC:EIF2AK3)) hasComponent p(HGNC:HSPA5) complex(p(HGNC:HSPA5),p(HGNC:EIF2AK3)) hasComponent p(HGNC:EIF2AK3) complex(p(HGNC:HSPA5),p(HGNC:EIF2AK3)) directlyDecreases kin(p(HGNC:EIF2AK3)) p(HGNC:CASP2) actsIn cat(p(HGNC:CASP2)) kin(p(SFAM:"PRKA Family")) decreases cat(p(HGNC:BAD)) kin(p(SFAM:"PRKA Family")) directlyIncreases tscript(p(HGNC:CREB1)) cat(p(HGNC:MCL1)) directlyDecreases cat(p(HGNC:BAK1)) cat(p(HGNC:MCL1)) directlyDecreases cat(p(HGNC:BAX)) bp(MESHPP:"DNA Fragmentation") increases bp(MESHPP:Apoptosis) kin(p(HGNC:IKBKE)) increases tscript(complex(SCOMP:"Nfkb Complex")) p(SFAM:"PRKC Family") actsIn kin(p(SFAM:"PRKC Family")) p(HGNC:PRKCA) isA p(SFAM:"PRKC Family") p(HGNC:PRKCD) isA p(SFAM:"PRKC Family") p(HGNC:PRKCE) isA p(SFAM:"PRKC Family") p(HGNC:PRKCZ) isA p(SFAM:"PRKC Family") p(SFAM:"MAPK JNK Family") actsIn kin(p(SFAM:"MAPK JNK Family")) p(HGNC:MAPK8) isA p(SFAM:"MAPK JNK Family") p(HGNC:MAPK10) isA p(SFAM:"MAPK JNK Family") p(HGNC:MAPK9) isA p(SFAM:"MAPK JNK Family") p(HGNC:PRKCA) actsIn kin(p(HGNC:PRKCA)) p(HGNC:PRKCA) directlyIncreases kin(p(HGNC:RAF1)) p(HGNC:CASP10) actsIn cat(p(HGNC:CASP10)) p(HGNC:BIRC2) decreases bp(MESHPP:Apoptosis) complex(p(HGNC:BRCA1),p(HGNC:TP53)) hasComponent p(HGNC:TP53) complex(p(HGNC:BRCA1),p(HGNC:TP53)) increases p(HGNC:BAX) deg(p(HGNC:LMNB1)) directlyDecreases p(HGNC:LMNB1) deg(p(HGNC:LMNB1)) increases bp(MESHPP:Apoptosis) p(HGNC:BCL2L11,pmod(P,T,116)) directlyIncreases cat(p(HGNC:BCL2L11)) p(SFAM:"PRKC Family") hasModification p(SFAM:"PRKC Family",pmod(P,S,660)) complex(p(HGNC:BAD),p(SFAM:"14-3-3 Family")) decreases bp(MESHPP:Apoptosis) kin(p(HGNC:PDPK1)) directlyIncreases p(HGNC:PRKCZ,pmod(P,T,410)) kin(p(HGNC:PDPK1)) increases kin(p(HGNC:PRKCA)) kin(p(HGNC:PDPK1)) directlyIncreases kin(p(SFAM:"PRKC Family")) kin(p(HGNC:PDPK1)) directlyIncreases kin(p(HGNC:PRKCD)) kin(p(HGNC:PDPK1)) directlyIncreases kin(p(HGNC:PRKCZ)) bp(GOBP:"response to oxidative stress") increases p(HGNC:TNFRSF10B) bp(GOBP:"response to oxidative stress") increases p(HGNC:TNFRSF10A) bp(GOBP:"response to oxidative stress") increases p(HGNC:TNFRSF10C) p(HGNC:CASP3) increases bp(MESHPP:Apoptosis) p(HGNC:CASP3) actsIn cat(p(HGNC:CASP3)) complex(SCOMP:"IkappaB Kinase Complex") actsIn kin(complex(SCOMP:"IkappaB Kinase Complex")) complex(SCOMP:"IkappaB Kinase Complex") hasComponent p(HGNC:CHUK) complex(SCOMP:"IkappaB Kinase Complex") hasComponent p(HGNC:IKBKG) complex(SCOMP:"IkappaB Kinase Complex") hasComponent p(HGNC:IKBKB) kin(p(HGNC:RIPK1)) increases kin(complex(SCOMP:"IkappaB Kinase Complex")) kin(p(HGNC:RIPK1)) directlyIncreases p(HGNC:MAP3K1,pmod(P,S,957)) kin(p(HGNC:RIPK1)) directlyIncreases p(HGNC:MAP3K1,pmod(P,S,994)) p(HGNC:FADD) actsIn cat(p(HGNC:FADD)) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:BAX) tscript(p(HGNC:TP53)) increases p(HGNC:IGFBP3) tscript(p(HGNC:TP53)) decreases p(HGNC:BCL2) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:PTEN) tscript(p(HGNC:TP53)) directlyDecreases p(HGNC:BIRC5) tscript(p(HGNC:TP53)) increases p(HGNC:DFFA) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:BAD) tscript(p(HGNC:TP53)) decreases p(HGNC:BCL2L1) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:RPS27L) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:CASP6) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:TNFSF10) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:TP53I3) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:PERP) tscript(p(HGNC:TP53)) directlyDecreases p(HGNC:BIRC3) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:CYFIP2) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:FAS) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:APAF1) tscript(p(HGNC:TP53)) increases p(HGNC:TP53INP1) tscript(p(HGNC:TP53)) directlyDecreases p(HGNC:BIRC2) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:BBC3) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:TNFRSF10C) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:PMAIP1) tscript(p(HGNC:TP53)) directlyIncreases p(EGID:55367) tscript(p(HGNC:TP53)) increases p(HGNC:TNFRSF1A) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:TNFRSF10A) tscript(p(HGNC:TP53)) increases p(HGNC:CASP8) tscript(p(HGNC:TP53)) increases p(HGNC:TNFRSF1B) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:TNFRSF10D) tscript(p(HGNC:TP53)) increases p(HGNC:RNF144B) tscript(p(HGNC:TP53)) decreases p(HGNC:XIAP) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:TNFRSF10B) tscript(p(HGNC:TP53)) increases p(HGNC:FASLG) tscript(p(HGNC:TP53)) directlyIncreases p(HGNC:BAK1) tscript(p(HGNC:TP53)) increases p(HGNC:BIK) p(HGNC:BCL2A1) decreases bp(MESHPP:Apoptosis) p(HGNC:CASP8) actsIn cat(p(HGNC:CASP8)) p(HGNC:TNFRSF1A) actsIn cat(p(HGNC:TNFRSF1A)) kin(complex(SCOMP:"IkappaB Kinase Complex")) directlyIncreases p(HGNC:NFKBIA,pmod(P,S,32)) kin(complex(SCOMP:"IkappaB Kinase Complex")) directlyIncreases p(HGNC:NFKBIA,pmod(P,S,36)) p(HGNC:PTEN,pmod(P,T,382)) directlyDecreases phos(p(HGNC:PTEN)) p(HGNC:RAC1,pmod(P,S,71)) directlyDecreases gtp(p(HGNC:RAC1)) cat(p(HGNC:CASP6)) directlyIncreases deg(p(HGNC:LMNA)) p(HGNC:CREB1) actsIn tscript(p(HGNC:CREB1)) p(HGNC:BIRC5) decreases bp(MESHPP:Apoptosis) p(HGNC:BIRC5) directlyDecreases cat(p(HGNC:CASP3)) p(HGNC:MAP3K1,pmod(P,S,957)) directlyIncreases kin(p(HGNC:MAP3K1)) p(HGNC:BAK1) actsIn cat(p(HGNC:BAK1)) p(HGNC:BID) actsIn cat(p(HGNC:BID)) p(HGNC:BAD,pmod(P,S,99)) directlyDecreases cat(p(HGNC:BAD)) p(HGNC:BAD,pmod(P,S,99)) increases complex(p(HGNC:BAD),p(SFAM:"14-3-3 Family")) kin(p(HGNC:RPS6KA1)) directlyIncreases p(HGNC:CREB1,pmod(P,S,133)) kin(p(HGNC:RPS6KA1)) decreases cat(p(HGNC:BAD)) kin(p(HGNC:RPS6KA1)) directlyIncreases p(HGNC:BAD,pmod(P,S,75)) deg(p(HGNC:LMNA)) directlyDecreases p(HGNC:LMNA) deg(p(HGNC:LMNA)) increases bp(MESHPP:Apoptosis) p(HGNC:IKBKE) actsIn kin(p(HGNC:IKBKE)) p(HGNC:CASP4) actsIn cat(p(HGNC:CASP4)) p(HGNC:TLR4) decreases p(HGNC:CASP3) kin(p(HGNC:MAP3K7)) directlyIncreases kin(complex(SCOMP:"IkappaB Kinase Complex")) p(HGNC:BCL2) decreases bp(MESHPP:Apoptosis) p(HGNC:BCL2) actsIn cat(p(HGNC:BCL2)) p(HGNC:ELK1,pmod(P,S,383)) directlyIncreases tscript(p(HGNC:ELK1)) cat(p(HGNC:CASP8)) increases cat(p(HGNC:BID)) cat(p(HGNC:CASP8)) directlyIncreases cat(p(HGNC:CASP3)) p(HGNC:CHUK) actsIn kin(p(HGNC:CHUK)) p(HGNC:BAX) increases bp(MESHPP:Apoptosis) p(HGNC:BAX) actsIn cat(p(HGNC:BAX)) p(HGNC:IKBKB) hasModification p(HGNC:IKBKB,pmod(P,S,181)) tscript(p(HGNC:CREB1)) increases p(HGNC:BCL2) p(HGNC:PTEN,pmod(P,S,380)) directlyDecreases phos(p(HGNC:PTEN)) tscript(p(HGNC:FOXO3)) directlyIncreases p(HGNC:BCL2L11) kin(p(HGNC:MAP3K1)) increases kin(p(HGNC:IKBKB)) p(HGNC:CASP9,pmod(P,T,125)) directlyDecreases cat(p(HGNC:CASP9)) kin(p(HGNC:PRKCZ)) directlyDecreases kin(p(SFAM:"AKT Family")) p(HGNC:TNFRSF1B) actsIn cat(p(HGNC:TNFRSF1B)) tscript(p(HGNC:ATF4)) directlyIncreases p(HGNC:DDIT3) kin(p(HGNC:BMX)) increases bp(MESHPP:Apoptosis) p(HGNC:PRKD1,pmod(P,S,742)) directlyIncreases kin(p(HGNC:PRKD1)) tscript(p(HGNC:EP300)) directlyIncreases tscript(p(HGNC:CREB1)) p(HGNC:PAK2) actsIn kin(p(HGNC:PAK2)) p(HGNC:PMAIP1) actsIn cat(p(HGNC:PMAIP1)) p(HGNC:PRKD1,pmod(P,S,738)) directlyIncreases kin(p(HGNC:PRKD1)) p(HGNC:RAF1,pmod(P,S,259)) directlyDecreases kin(p(HGNC:RAF1)) p(HGNC:TNF) directlyIncreases cat(p(HGNC:TNFRSF1A)) p(HGNC:TNF) increases p(HGNC:TNFRSF10A) p(HGNC:TNF) increases p(HGNC:TNFRSF10B) p(HGNC:TNF) directlyIncreases cat(p(HGNC:TNFRSF1B)) p(HGNC:TNF) increases p(HGNC:TNFRSF10C) p(HGNC:BCL2L1) actsIn cat(p(HGNC:BCL2L1)) p(HGNC:BCL2L1) decreases bp(MESHPP:Apoptosis) p(HGNC:NFKBIE) directlyDecreases tscript(complex(SCOMP:"Nfkb Complex")) p(HGNC:RIPK1) actsIn kin(p(HGNC:RIPK1)) p(HGNC:AKT1,pmod(P,T,308)) directlyIncreases kin(p(HGNC:AKT1)) p(HGNC:TNFRSF10A) actsIn cat(p(HGNC:TNFRSF10A)) p(HGNC:TNFRSF10A) increases bp(MESHPP:Apoptosis) p(HGNC:MAP3K1) actsIn kin(p(HGNC:MAP3K1)) cat(p(HGNC:TRADD)) increases cat(p(HGNC:CASP8)) p(HGNC:PARP1) decreases bp(MESHPP:Apoptosis) kin(p(SFAM:"AKT Family")) directlyIncreases p(HGNC:BAX,pmod(P,S,184)) kin(p(HGNC:AKT2)) isA kin(p(SFAM:"AKT Family")) kin(p(SFAM:"AKT Family")) directlyIncreases p(HGNC:RAF1,pmod(P,S,259)) kin(p(SFAM:"AKT Family")) directlyIncreases p(HGNC:BAD,pmod(P,S,99)) kin(p(HGNC:AKT3)) isA kin(p(SFAM:"AKT Family")) kin(p(SFAM:"AKT Family")) directlyIncreases p(HGNC:RAC1,pmod(P,S,71)) kin(p(SFAM:"AKT Family")) directlyIncreases p(HGNC:MAP3K5,pmod(P,S,83)) kin(p(SFAM:"AKT Family")) directlyDecreases tscript(p(SFAM:"FOXO Family")) kin(p(SFAM:"AKT Family")) directlyIncreases p(HGNC:FOXO1,pmod(P,S,256)) kin(p(HGNC:AKT1)) isA kin(p(SFAM:"AKT Family")) kin(p(SFAM:"AKT Family")) directlyIncreases p(HGNC:BAD,pmod(P,S,75)) p(HGNC:BAD) actsIn cat(p(HGNC:BAD)) cat(p(HGNC:FAS)) directlyIncreases cat(p(HGNC:FADD)) kin(p(HGNC:MAP3K5)) increases bp(MESHPP:Apoptosis) kin(p(HGNC:MAP3K5)) directlyIncreases kin(p(HGNC:MAP2K7)) tscript(p(HGNC:FOXO1)) directlyIncreases p(HGNC:BCL2L11) complex(p(HGNC:HSPA5),p(HGNC:ERN1)) hasComponent p(HGNC:ERN1) complex(p(HGNC:HSPA5),p(HGNC:ERN1)) hasComponent p(HGNC:HSPA5) complex(p(HGNC:HSPA5),p(HGNC:ERN1)) directlyDecreases cat(p(HGNC:ERN1)) phos(p(HGNC:PTEN)) decreases kin(p(SFAM:"PIK3C Class IA Family")) p(HGNC:XBP1) actsIn tscript(p(HGNC:XBP1)) p(HGNC:AKT1,pmod(P,S,473)) directlyIncreases kin(p(HGNC:AKT1)) p(HGNC:CFLAR) decreases bp(MESHPP:Apoptosis) p(HGNC:CFLAR) decreases cat(p(HGNC:CASP8)) kin(p(HGNC:RAF1)) increases tscript(p(HGNC:ELK1)) kin(p(HGNC:MAPK8)) isA kin(p(SFAM:"MAPK JNK Family")) kin(p(SFAM:"MAPK JNK Family")) directlyIncreases p(HGNC:BCL2L11,pmod(P,T,116)) kin(p(HGNC:MAPK10)) isA kin(p(SFAM:"MAPK JNK Family")) kin(p(SFAM:"MAPK JNK Family")) increases cat(p(HGNC:BAX)) kin(p(HGNC:MAPK9)) isA kin(p(SFAM:"MAPK JNK Family")) p(HGNC:BCL2L11,pmod(P,S,69)) decreases cat(p(HGNC:BCL2L11)) p(HGNC:DFFB) actsIn cat(p(HGNC:DFFB)) p(HGNC:CHUK) hasModification p(HGNC:CHUK,pmod(P,S,180)) cat(p(HGNC:BID)) directlyIncreases cat(p(HGNC:BAX)) cat(p(HGNC:BID)) directlyIncreases cat(p(HGNC:BAK1)) cat(p(HGNC:BID)) increases bp(MESHPP:Apoptosis) deg(p(HGNC:LMNB2)) directlyDecreases p(HGNC:LMNB2) deg(p(HGNC:LMNB2)) increases bp(MESHPP:Apoptosis) p(HGNC:FASLG) directlyIncreases cat(p(HGNC:FAS)) p(SFAM:"AKT Family") actsIn kin(p(SFAM:"AKT Family")) p(HGNC:AKT3) isA p(SFAM:"AKT Family") p(HGNC:AKT1) isA p(SFAM:"AKT Family") p(HGNC:AKT2) isA p(SFAM:"AKT Family") p(HGNC:MAP3K5,pmod(P,S,83)) directlyDecreases kin(p(HGNC:MAP3K5)) cat(p(HGNC:DFFB)) increases bp(MESHPP:"DNA Fragmentation") p(HGNC:DDIT3) actsIn tscript(p(HGNC:DDIT3)) p(HGNC:DDIT3) increases p(HGNC:BBC3) p(HGNC:DDIT3) increases p(HGNC:BAX) p(HGNC:DDIT3) increases p(HGNC:BCL2L11) p(HGNC:FOXO1) actsIn tscript(p(HGNC:FOXO1)) cat(p(HGNC:PMAIP1)) increases cat(p(HGNC:BAK1)) cat(p(HGNC:PMAIP1)) increases cat(p(HGNC:BAX)) p(HGNC:CASP6) actsIn cat(p(HGNC:CASP6)) kin(p(HGNC:MAP2K7)) directlyIncreases kin(p(SFAM:"MAPK JNK Family")) cat(p(HGNC:XIAP)) decreases cat(p(HGNC:CASP3)) cat(p(HGNC:XIAP)) decreases cat(p(HGNC:CASP9)) cat(p(HGNC:XIAP)) decreases cat(p(HGNC:CASP7)) gtp(p(HGNC:RAC1)) increases kin(p(SFAM:"MAPK JNK Family")) gtp(p(HGNC:RAC1)) increases kin(p(HGNC:MAPK10)) gtp(p(HGNC:RAC1)) directlyIncreases kin(p(HGNC:MAPK8)) a(SCHEM:"Phosphatidylinositol-3,4,5-trisphosphate") directlyIncreases kin(p(HGNC:PDPK1)) cat(p(HGNC:CASP4)) increases bp(MESHPP:Apoptosis) cat(p(HGNC:ACIN1)) increases bp(MESHPP:Apoptosis) p(HGNC:ELK1) actsIn tscript(p(HGNC:ELK1)) p(HGNC:PRKCE) actsIn kin(p(HGNC:PRKCE)) p(HGNC:ROCK1) actsIn kin(p(HGNC:ROCK1)) a(SCHEM:Calcium) increases kin(p(HGNC:PRKCA)) a(SCHEM:Calcium) increases kin(p(HGNC:PRKCD)) a(SCHEM:Calcium) directlyIncreases kin(p(SFAM:"PRKC Family")) a(SCHEM:Calcium) increases kin(p(HGNC:PRKCE)) kin(p(HGNC:NFKBIA)) decreases tscript(complex(SCOMP:"Nfkb Complex")) kin(p(HGNC:PRKD1)) directlyIncreases kin(p(HGNC:MAP3K5)) p(HGNC:TRADD) actsIn cat(p(HGNC:TRADD)) p(HGNC:BBC3) actsIn cat(p(HGNC:BBC3)) p(HGNC:BBC3) increases bp(MESHPP:Apoptosis) kin(p(HGNC:RPS6KA1)) isA kin(p(SFAM:"RPS6KA Family")) cat(p(HGNC:TNFRSF10A)) increases cat(p(HGNC:TRAF2)) cat(p(HGNC:DFFA)) decreases cat(p(HGNC:DFFB)) p(SFAM:"RPS6KA Family") actsIn kin(p(SFAM:"RPS6KA Family")) cat(p(HGNC:HTRA2)) directlyDecreases cat(p(HGNC:XIAP)) p(HGNC:MAP3K7) actsIn kin(p(HGNC:MAP3K7)) p(HGNC:MARCKS) hasModification p(HGNC:MARCKS,pmod(P,S,159)) p(HGNC:CREB1,pmod(P,S,133)) directlyIncreases tscript(p(HGNC:CREB1)) p(HGNC:EIF2S1,pmod(P,S,52)) increases p(HGNC:ATF4) p(HGNC:EIF2S1) hasModification p(HGNC:EIF2S1,pmod(P,S,52)) p(HGNC:NFKBIA,pmod(P,S,32)) directlyIncreases deg(p(HGNC:NFKBIA)) p(HGNC:CASP7) actsIn cat(p(HGNC:CASP7)) deg(p(HGNC:NFKBIA)) directlyDecreases p(HGNC:NFKBIA) p(HGNC:PDPK1,pmod(P,S,241)) increases p(HGNC:PDPK1) p(HGNC:CXCL12) increases gtp(p(HGNC:RAC1)) p(CXCL12) increases gtp(p(HGNC:RAC1)) bp(MESHPP:Apoptosis) positiveCorrelation p(HGNC:TLR4) bp(MESHPP:Apoptosis) negativeCorrelation p(HGNC:GSTP1) p(HGNC:MAP1LC3B) increases bp(MESHPP:Apoptosis) p(HGNC:KDR) decreases bp(MESHPP:Apoptosis) p(HGNC:KDR) decreases path(MESHD:Emphysema) bp(MESHPP:"DNA Methylation") association path(MESHD:"Pulmonary Disease, Chronic Obstructive") bp(MESHPP:"DNA Methylation") association bp(MESHPP:Apoptosis) path(MESHD:"Pulmonary Disease, Chronic Obstructive") increases bp(MESHPP:Apoptosis) p(HGNC:PTGS2) association a(SCHEM:"Smoke, cigarette") p(HGNC:PTGS2) negativeCorrelation bp(MESHPP:Apoptosis) a(SCHEM:"Smoke, cigarette") increases p(HGNC:HSPA5) p(HGNC:HSPA5) decreases p(HGNC:CASP3) p(HGNC:SCGB1A1) decreases bp(MESHPP:Apoptosis) p(HGNC:EIF2AK3) decreases bp(MESHPP:Apoptosis) p(HGNC:FLOT2) decreases p(HGNC:DIABLO) p(HGNC:PGF) increases bp(MESHPP:Apoptosis) kin(p(SFAM:"MAPK JNK Family")) increases bp(MESHPP:Apoptosis) kin(p(SFAM:"PRKC Family")) increases bp(MESHPP:Apoptosis) p(HGNC:BACH2) increases kin(p(SFAM:"MAPK JNK Family")) cat(p(HGNC:TRADD)) increases cat(p(HGNC:FADD))