Mercurial > repos > davidvanzessen > shm_csr
view shm_transition.htm @ 55:6cd12c71c3d3 draft
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author | davidvanzessen |
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date | Wed, 14 Jun 2017 11:14:00 -0400 |
parents | a24f8c93583a |
children | ba33b94637ca |
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<html> <head> <meta http-equiv=Content-Type content="text/html; charset=windows-1252"> <meta name=Generator content="Microsoft Word 14 (filtered)"> <style> <!-- /* Font Definitions */ @font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {margin-top:0in; margin-right:0in; margin-bottom:10.0pt; margin-left:0in; line-height:115%; font-size:11.0pt; font-family:"Calibri","sans-serif";} a:link, span.MsoHyperlink {color:blue; text-decoration:underline;} a:visited, span.MsoHyperlinkFollowed {color:purple; text-decoration:underline;} p.msochpdefault, li.msochpdefault, div.msochpdefault {mso-style-name:msochpdefault; margin-right:0in; margin-left:0in; font-size:12.0pt; font-family:"Calibri","sans-serif";} p.msopapdefault, li.msopapdefault, div.msopapdefault {mso-style-name:msopapdefault; margin-right:0in; margin-bottom:10.0pt; margin-left:0in; line-height:115%; font-size:12.0pt; font-family:"Times New Roman","serif";} span.apple-converted-space {mso-style-name:apple-converted-space;} .MsoChpDefault {font-size:10.0pt; font-family:"Calibri","sans-serif";} .MsoPapDefault {margin-bottom:10.0pt; line-height:115%;} @page WordSection1 {size:8.5in 11.0in; margin:1.0in 1.0in 1.0in 1.0in;} div.WordSection1 {page:WordSection1;} --> </style> </head> <body lang=EN-US link=blue vlink=purple> <div class=WordSection1> <p class=MsoNormalCxSpFirst style='text-align:justify'><span style='font-size: 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These graphs and tables give insight into the targeting and patterns of SHM. This can give insight into the DNA repair pathways used to solve the U:G mismatches introduced by AID. More information on the values found in healthy individuals of different ages can be found in IJspeert and van Schouwenburg et al, PMID: 27799928.</span></p> <p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs </span></b></p> <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK93"></a><a name="OLE_LINK92"></a><a name="OLE_LINK91"><u><span style='font-size:12.0pt; line-height:115%;font-family:"Times New Roman","serif"'>Heatmap transition information</span></u></a></p> <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK98"></a><a name="OLE_LINK97"><span style='font-size:12.0pt;line-height:115%;font-family: "Times New Roman","serif"'>Heatmaps visualizing for each subclass the frequency of all possible substitutions. On the x-axes the original base is shown, while the y-axes shows the new base. The darker the shade of blue, the more frequent this type of substitution is occurring. </span></a></p> <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bargraph transition information</span></u></p> <p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size: 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bar graph visualizing for each original base the distribution of substitutions into the other bases. A graph is included for each (sub)class. </span></p> <p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Tables</span></b></p> <p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size: 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Transition tables are shown for each (sub)class. All the original bases are listed horizontally, while the new bases are listed vertically. </span></p> <p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%; font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen, Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span style='color:windowtext'>Link</span></a>]</span></p> </div> </body> </html>