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1 #Gene_ID Gene_name Codon_pos Ref_nuc Ref_codon Res_codon Resistance PMID Mechanism Notes Required_mut
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2 penA penA 501 GCG A V,T,P Cephalosporins 24982323,24982323,27432602
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3 penA penA 542 GGC G S Cephalosporins 20511367 Only statistically associated with enhanced resistance
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4 penA penA 551 CCG P S,L Cephalosporins 20511367,20511367 Only statistically associated with enhanced resistance
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5 penA penA 311 GCA A V Cephalosporins 24982323 Mutation indicates mosaic penA gene
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6 penA penA 312 ATC I M Cephalosporins 24982323 Mutation indicates mosaic penA gene
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7 penA penA 316 GTG V T Cephalosporins 24982323 Mutation indicates mosaic penA gene
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8 penA penA 483 ACC T S Cephalosporins 24982323 Mutation indicates mosaic penA gene
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9 penA penA 512 AAC N Y Cephalosporins 24982323 Mutation indicates mosaic penA gene
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10 penA penA 545 GGC G S Cephalosporins 24982323 Mutation indicates mosaic penA gene
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11 penA penA 546 GGC G S Cephalosporins 24982323 Mutation indicates mosaic penA gene
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12 mtrR_promoter_size_66bp mtrR 45 GGC G D Penicillins,Tetracyclines,Cephalosporins,Macrolides 7773394
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13 pilQ pilQ 666 GAA E K Penicillins,Tetracyclines,Ciprofloxacin 24982323 Only effective in the presents of the mtrR and penB (porB mutation) resistance determinants
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14 rpsJ rpsJ 57 GTG V M,L,Q Tetracyclines 16189114,16189114,16189114
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15 rpsE rpsE 28 AAA K E Spectinomycin 23183436 Mutation seen together with V27 deletion
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16 rpsE rpsE 24 ACC T P Spectinomycin 23183436 Low-level resistance
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17 gyrA gyrA 91 TCC S F Quinolones 12529019 Mutation often seen together with D95N/G mutation (PMID: 23347339)
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18 gyrA gyrA 95 GAC D N,G Quinolones 12529019,12529019 Mutation often seen together with S91F mutation (PMID: 23347339)
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19 parC parC 91 GAG E G,Q,K Quinolones 24982323,24982323,24982323 High-level resistance when additional to gyrA S91P and gyrA D95N/G gyrA_D95N.G,gyrA_S91P
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20 parC parC 88 TCC S P Quinolones 24982323 High-level resistance when additional to gyrA S91P and gyrA D95N/G gyrA_D95N.G,gyrA_S91P
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21 porB porB 120 GGC G D Penicillins,Tetracyclines,Cephalosporins 12183233 Solo mutation gives partial resistance porB_A121D
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22 porB porB 121 GCC A D Penicillins,Tetracyclines,Cephalosporins 12183233 Solo muttaion gives partial resistance porB_G120D
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23 porB porB 120 GGC G R Penicillins,Tetracyclines,Cephalosporins 12183233 porB_A121H
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24 porB porB 121 GCC A H Penicillins,Tetracyclines,Cephalosporins 12183233 porB_G120R
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25 porB porB 120 GGC G P Penicillins,Tetracyclines,Cephalosporins 12183233 porB_A121P
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26 porB porB 121 GCC A P Penicillins,Tetracyclines,Cephalosporins 12183233 porB_G120P
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27 porB porB 120 GGC G K Penicillins,Tetracyclines,Cephalosporins 12183233
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28 ponA ponA 421 CTG L P Penicillins 11850260 Mediates transformation of intermediate-level penicillin-resistant transformants to high-level penicillin resistance
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29 16S_rRNA 16S_rRNA 1192 C C T Spectinomycin 24982323
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30 23S_rRNA_a1 23S_rRNA_a1 2604 C C T Macrolides 12183262 C2611T mutation (Escherichia coli numbering)
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31 23S_rRNA_a2 23S_rRNA_a2 2603 C C T Macrolides 12183262 C2611T mutation (Escherichia coli numbering)
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32 23S_rRNA_a3 23S_rRNA_a3 2603 C C T Macrolides 12183262 C2611T mutation (Escherichia coli numbering)
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33 23S_rRNA_a4 23S_rRNA_a4 2610 C C T Macrolides 12183262 C2611T mutation (Escherichia coli numbering)
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34 23S_rRNA_a1 23S_rRNA_a1 2051 A A G Macrolides 12183262,20585125 A2058G mutation (Escherichia coli numbering)
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35 23S_rRNA_a2 23S_rRNA_a2 2050 A A G Macrolides 12183262,20585125 A2058G mutation (Escherichia coli numbering)
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36 23S_rRNA_a3 23S_rRNA_a3 2050 A A G Macrolides 12183262,20585125 A2058G mutation (Escherichia coli numbering)
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37 23S_rRNA_a4 23S_rRNA_a4 2054 A A G Macrolides 12183262,20585125 A2058G mutation (Escherichia coli numbering)
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38 mtrC_promoter_size_174bp mtr120 promoter -120 C C T Penicillins,Tetracyclines,Cephalosporins,Macrolides,Rifampicin,Erythromycin 21933917 -10 hexamer (TATAAC->TATAAT) is created as an alternative transcription start point
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39 macAB_promoter_size_225bp macAB promoter -48 G G T Macrolides 16162665
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40 #Indels
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41 #Gene_ID Gene_name Codon_pos Ref_nuc Ref_codon Res_codon Resistance PMID Mechanism Notes Required_mut
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42 #penA penA 346 - ins D Cephalosporins 24982323 Often denoted 'D345a' or 'D345 insertion'
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43 #rpsE rpsE 27 GTT V del Spectinomycin 23183436
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44 penA penA 1035 - ins GAT,GAC Cephalosporins 24982323,24982323 Often denoted 'D345a' or 'D345 insertion'
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45 mtrR_promoter_size_66bp mtrR promoter -57 - del A Penicillins,Tetracyclines,Cephalosporins,Macrolides 24982323 Deletion in 13bp inverted repeat
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46 rpsE rpsE 78 - del GTT Spectinomycin 23183436
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