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1 #####################################################################################
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2 #Copyright (C) <2012>
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3 #
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4 #Permission is hereby granted, free of charge, to any person obtaining a copy of
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5 #this software and associated documentation files (the "Software"), to deal in the
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6 #Software without restriction, including without limitation the rights to use, copy,
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7 #modify, merge, publish, distribute, sublicense, and/or sell copies of the Software,
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8 #and to permit persons to whom the Software is furnished to do so, subject to
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9 #the following conditions:
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10 #
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11 #The above copyright notice and this permission notice shall be included in all copies
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12 #or substantial portions of the Software.
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13 #
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14 #THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED,
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15 #INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
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16 #PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
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17 #HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
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18 #OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE
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19 #SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
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20 #
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21 # This file is a component of the MaAsLin (Multivariate Associations Using Linear Models),
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22 # authored by the Huttenhower lab at the Harvard School of Public Health
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23 # (contact Timothy Tickle, ttickle@hsph.harvard.edu).
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24 #####################################################################################
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25
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26 inlinedocs <- function(
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27 ##author<< Curtis Huttenhower <chuttenh@hsph.harvard.edu> and Timothy Tickle <ttickle@hsph.harvard.edu>
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28 ##description<< Collection of functions centered on custom reading of data and some IO services.
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29 ) { return( pArgs ) }
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30
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31 #Project Constants
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32
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33 c_astrNA <- c(""," "," ","NA","na")
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34
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35 #Do not report warnings
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36 options(warn=-1)
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37
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38 funcWriteMatrixToReadConfigFile = function(
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39 ### Writes a read config file. Will write over a file by default
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40 strConfigureFileName,
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41 ### Matrix that will be read
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42 strMatrixName,
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43 ### Name of matrix that will be read
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44 strRowIndices=NA,
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45 ### Rows which will be Read (TSV) by default all will be read
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46 strColIndices=NA,
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47 ### Cols which will be Read (TSV) by default all will be read
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48 acharDelimiter=c_strDefaultMatrixDelimiter,
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49 ### Delimiter for the matrix that will be read in\
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50 fAppend=FALSE
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51 ### Append to a current read config file
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52 ){
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53 #If no append delete previous file
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54 if(!fAppend){unlink(strConfigureFileName)}
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55
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56 #Make delimiter readable
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57 switch(acharDelimiter,
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58 "\t" = {acharDelimiter = "TAB"},
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59 " " = {acharDelimiter = "SPACE"},
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60 "\r" = {acharDelimiter = "RETURN"},
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61 "\n" = {acharDelimiter = "ENDLINE"})
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62
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63 #Manage NAs
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64 if(is.na(strRowIndices)){strRowIndices="-"}
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65 if(is.na(strColIndices)){strColIndices="-"}
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66
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67 #Required output
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68 lsDataLines = c(paste(c_MATRIX_NAME,strMatrixName,sep=" "),
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69 paste(c_DELIMITER,acharDelimiter,sep=" "),
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70 paste(c_ID_ROW,"1",sep=" "),
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71 paste(c_ID_COLUMN,"1",sep=" "),
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72 paste(c_TSVROWS,strRowIndices,sep=" "),
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73 paste(c_TSVCOLUMNS,strColIndices,sep=" "))
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74
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75 lsDataLines = c(lsDataLines,"\n")
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76
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77 #Output to file
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78 lapply(lsDataLines, cat, file=strConfigureFileName, sep="\n", append=TRUE)
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79 }
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80
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81 funcWriteMatrices = function(
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82 ### Write data frame data files with config files
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83 dataFrameList,
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84 ### A named list of data frames (what you get directly from the read function)
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85 saveFileList,
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86 ### File names to save the data matrices in (one name per data frame)
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87 configureFileName,
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88 ### Name of the configure file to be written which will direct the reading of these data
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89 acharDelimiter=c_strDefaultMatrixDelimiter,
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90 ### Matrix delimiter
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91 log = FALSE
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92 ### Indicates if logging should occur
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93 ){
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94 #Get names
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95 dataFrameNames = names(dataFrameList)
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96
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97 #Get length of dataFrameList
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98 dataFrameListLength = length(dataFrameList)
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99
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100 #Get length of save file list
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101 saveFileListLength = length(saveFileList)
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102
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103 #If the save file list length and data frame list length are not equal, abort
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104 if(!saveFileListLength == dataFrameListLength)
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105 {stop(paste("Received a length of save files (",saveFileListLength,") that are different from the count of data frames (",dataFrameListLength,"). Stopped and returned false."),sep="")}
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106
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107 #Delete the old config file
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108 unlink(configureFileName)
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109
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110 #For each data save
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111 for (dataIndex in c(1:dataFrameListLength))
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112 {
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113 #Current data frame
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114 data = dataFrameList[[dataIndex]]
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115
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116 #Get column count
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117 columnCount = ncol(data)
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118
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119 #Get row and column names
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120 rowNames = row.names(data)
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121 rowNamesString = paste(rowNames,sep="",collapse=",")
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122 if(length(rowNamesString)==0){rowNamesString = NA}
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123
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124 columnNamesString = paste(colnames(data),sep="",collapse=",")
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125 if(length(columnNamesString)==0){columnNamesString = NA}
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126
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127 #Get row indices
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128 rowStart = 1
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129 if(!is.na(rowNamesString)){rowStart = 2}
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130 rowEnd = nrow(data)+rowStart - 1
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131 rowIndices = paste(c(rowStart:rowEnd),sep="",collapse=",")
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132
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133 #Get col indices
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134 colStart = 1
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135 if(!is.na(columnNamesString)){ colStart = 2}
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136 colEnd = columnCount+colStart - 1
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137 colIndices = paste(c(colStart:colEnd),sep="",collapse=",")
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138
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139 #Write Data to file
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140 write.table(data, saveFileList[dataIndex], quote = FALSE, sep = acharDelimiter, col.names = NA, row.names = rowNames, na = "NA", append = FALSE)
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141
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142 #Write the read config file
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143 funcWriteMatrixToReadConfigFile(strConfigureFileName=configureFileName, strMatrixName=dataFrameNames[dataIndex],
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144 strRowIndices=rowIndices, strColIndices=colIndices, acharDelimiter=acharDelimiter, fAppend=TRUE)
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145 }
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146 return(TRUE)
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147 }
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148
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149 funcReadMatrices = function(
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150 ### Dynamically Read a Matrix/Matrices from a configure file
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151 configureFile,
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152 ### Read config file to guide reading in data
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153 defaultFile = NA,
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154 ### Default data file to read
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155 log = FALSE
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156 ){
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157 #Named vector to return data frames read
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158 returnFrames = list()
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159 #Holds the names of the frames as they are being added
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160 returnFrameNames = c()
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161 returnFramesIndex = 1
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162
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163 #Read in config file info
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164 #Read each data block extracted from the config file
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165 lsDataBlocks <- funcReadConfigFile(configureFile, defaultFile)
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166 if(!length(lsDataBlocks)) {
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167 astrMetadata <- NULL
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168 astrMetadata[2] <- defaultFile
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169 astrMetadata[5] <- "2"
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170 astrData <- NULL
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171 astrData[2] <- defaultFile
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172 astrData[5] <- "3-"
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173 lsDataBlocks <- list(astrMetadata, astrData)
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174 }
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175 for(dataBlock in lsDataBlocks)
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176 {
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177 #Read in matrix
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178 returnFrames[[returnFramesIndex]] = funcReadMatrix(tempMatrixName=dataBlock[1], tempFileName=dataBlock[2], tempDelimiter=dataBlock[3], tempColumns=dataBlock[5], tempRows=dataBlock[4], tempLog=log)
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179 returnFrameNames = c(returnFrameNames,dataBlock[1])
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180 returnFramesIndex = returnFramesIndex + 1
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181 }
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182 names(returnFrames) = returnFrameNames
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183 return(returnFrames)
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184 }
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185
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186 funcReadMatrix = function(
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187 ### Read one matrix
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188 ### The name to give the block of data read in from file
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189 tempMatrixName,
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190 ### ID rows and columns are assumed to be 1
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191 tempFileName=NA,
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192 ### Data file to read
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193 tempDelimiter=NA,
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194 ### Data matrix delimiter
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195 tempColumns=NA,
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196 ### Data columns to read
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197 tempRows=NA,
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198 ### Data rows to read
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199 tempLog=FALSE
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200 ### Indicator to log
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201 ){
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202 if(is.na(tempDelimiter)){tempDelimiter <- c_strDefaultMatrixDelimiter}
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203 if(is.na(tempColumns)){tempColumns <- c_strDefaultReadCols}
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204 if(is.na(tempRows)){tempRows <- c_strDefaultReadRows}
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205
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206 #Check parameter and make sure not NA
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207 if(is.na(tempMatrixName)){tempMatrixName <- ""}
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208 if(!funcIsValid(tempMatrixName)){stop(paste("Did not receive a valid matrix name, received ",tempMatrixName,"."))}
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209
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210 #Check to make sure there is a file name for the matrix
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211 if(! funcIsValidFileName(tempFileName))
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212 {stop(paste("No valid file name is given for the matrix ",tempMatrixName," from file: ",tempFileName,". Please add a valid file name to read the matrix from.", sep=""))}
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213
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214 #Read in superset matrix and give names if indicated
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215 #Read in matrix
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216 dataMatrix = read.table(tempFileName, sep = tempDelimiter, as.is = TRUE, na.strings=c_astrNA, quote = "", comment.char = "")
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217 dataFrameDimension = dim(dataMatrix)
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218
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219 #Get column names
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220 columnNameList = as.matrix(dataMatrix[1,])
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221 rowNameList = dataMatrix[1][[1]]
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222
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223 #Convert characters to vectors of indices
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224 tempColumns = funcParseIndexSlices(ifelse(is.na(tempColumns),"-",tempColumns), columnNameList)
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225 tempRows = funcParseIndexSlices(ifelse(is.na(tempRows),"-", tempRows), rowNameList)
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226
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227 #Check indices
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228 #Check to make sure valid id col/rows and data col/rows
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229 if((!funcIsValid(tempColumns)) || (!funcIsValid(tempRows)))
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230 {stop(paste("Received invalid row or col. Rows=",tempRows," Cols=", tempColumns))}
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231
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232 #Check to make sure only 1 row id is given and it is not repeated in the data rows
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233 if(length(intersect(1,tempColumns)) == 1)
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234 {stop(paste("Index indicated as an id row but was found in the data row indices, can not be both. Index=1 Data indices=",tempColumns,sep=""))}
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235
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236 #Check to make sure only one col id is given and it is not repeated in the data columns
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237 #Id row/col should not be in data row/col
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238 if(length(intersect(1, tempRows)) == 1)
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239 {stop(paste("Index indicated as an id column but was found in the data column indices, can not be both. ID Index=1 Data Indices=", tempRows,".",sep=""))}
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240
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241 #If the row names have the same length as the column count and has column names
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242 #it is assumed that the tempIdCol index item is associated with the column names.
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243 #Visa versa for rows, either way it is removed
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244 #Remove ids from name vector
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245 rowNameList = rowNameList[(-1)]
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246 #Remove ids from data
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247 dataMatrix = dataMatrix[(-1)]
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248 #Adjust row ids given the removal of the id row
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249 tempColumns=(tempColumns-1)
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250
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251 ## Remove id rows/columns and set row/col names
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252 #Remove ids from vector
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253 columnNameList = columnNameList[(-1)]
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254 #Remove ids from data
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255 dataMatrix = dataMatrix[(-1),]
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256 #Adjust column ids given the removal of the id column
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257 tempRows =(tempRows-1)
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258 #Add row and column names
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259 row.names(dataMatrix) = as.character(rowNameList)
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260 colnames(dataMatrix) = as.character(columnNameList)
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261
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262 #Reduce matrix
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263 #Account for when both column ranges and row ranges are given or just a column or a row range is given
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264 dataMatrix = dataMatrix[tempRows, tempColumns, drop=FALSE]
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265
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266 #Set all columns data types to R guessed default
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267 for(i in 1:ncol(dataMatrix)){
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268 dataMatrix[,i] <- type.convert(dataMatrix[,i], na.strings = c_astrNA)}
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269
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270 #Return matrix
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271 return(dataMatrix)
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272 }
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273
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274 funcReadConfigFile = function(
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275 ### Reads in configure file and extracts the pieces needed for reading in a matrix
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276 configureFile,
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277 ### Configure file = string path to configure file
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278 defaultFile = NA
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279 ### Used to set a default data file
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280 ){
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281 #Read configure file
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282 fileDataList <- list()
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283 if(!is.null( configureFile ) ) {
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284 fileDataList <- scan( file = configureFile, what = character(), sep="\n", quiet=TRUE) }
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285 newList = list()
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286 for(sLine in fileDataList)
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287 {
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288 sLine = gsub("\\s","",sLine)
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289 vUnits = unlist(strsplit(sLine,":"))
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290 if(length(vUnits)>1)
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291 {
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292 vUnits[1] = paste(vUnits[1],":",sep="")
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293 newList[[length(newList)+1]] = vUnits
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294 }
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295 }
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296 fileDataList = unlist(newList)
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297
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298 matrixName <- NA
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299 fileName <- defaultFile
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300
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301 #Hold information on matrices to be read
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302 matrixInformationList = list()
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303 matrixInformationListCount = 1
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304
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305 for(textIndex in c(1:length(fileDataList)))
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306 {
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307 if(textIndex > length(fileDataList)) {break}
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308 #Start at the Matrix name
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309 #Keep this if statement first so that you scan through until you find a matrix block
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310 if(fileDataList[textIndex] == c_MATRIX_NAME)
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311 {
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312 #If the file name is not NA then that is sufficient for a matrix, store
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313 #Either way reset
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314 if(funcIsValid(fileName)&&funcIsValid(matrixName))
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315 {
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316 matrixInformationList[[matrixInformationListCount]] = c(matrixName,fileName,delimiter,rows,columns)
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317 matrixInformationListCount = matrixInformationListCount + 1
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318 }
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319
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320 #Get the matrix name and store
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321 matrixName = fileDataList[textIndex + 1]
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322
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323 fileName = defaultFile
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324 delimiter = "\t"
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325 rows = NA
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326 columns = NA
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327 #If is not matrix name and no matrix name is known skip until you find the matrix name
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328 #If matrix name is known, continue to collect information about that matrix
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329 } else if(is.na(matrixName)){next}
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330
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331 #Parse different keywords
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332 strParseKey = fileDataList[textIndex]
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333 if(strParseKey == c_FILE_NAME){fileName=fileDataList[textIndex+1]}
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334 else if(strParseKey==c_FILE_NAME){fileName=fileDataList[textIndex+1]}
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335 else if(strParseKey %in% c(c_TSVROWS,c_PCLCOLUMNS,c_ROWS)){rows=fileDataList[textIndex+1]}
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336 else if(strParseKey %in% c(c_TSVCOLUMNS,c_PCLROWS,c_COLUMNS)){columns=fileDataList[textIndex+1]}
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337 else if(strParseKey==c_DELIMITER)
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338 {
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339 switch(fileDataList[textIndex + 1],
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340 "TAB" = {delimiter = "\t"},
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341 "SPACE" = {delimiter = " "},
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342 "RETURN" = {delimiter = "\r"},
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343 "ENDLINE" = {delimiter = "\n"})
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344 }
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345 }
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346 #If there is matrix information left
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347 if((!is.na(matrixName)) && (!is.na(fileName)))
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348 {
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349 matrixInformationList[[matrixInformationListCount]] = c(matrixName,fileName,delimiter,rows,columns)
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350 matrixInformationListCount = matrixInformationListCount + 1
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351 }
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352 return(matrixInformationList)
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353 }
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354
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355 funcParseIndexSlices = function(
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356 ### Take a string of comma or dash seperated integer strings and convert into a vector
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357 ### of integers to use in index slicing
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358 strIndexString,
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359 ### String to be parsed into indicies vector
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360 cstrNames
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361 ### Column names of the data so names can be resolved to indicies
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362 ){
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363 #If the slices are NA then return
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364 if(is.na(strIndexString)){return(strIndexString)}
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365
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366 #List of indices to return
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367 viRetIndicies = c()
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368
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369 #Split on commas
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370 lIndexString = sapply(strsplit(strIndexString, c_COMMA),function(x) return(x))
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371 for(strIndexItem in lIndexString)
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372 {
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373 #Handle the - case
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374 if(strIndexItem=="-"){strIndexItem = paste("2-",length(cstrNames),sep="")}
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375
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376 #Split on dash and make sure it makes sense
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377 lItemElement = strsplit(strIndexItem, c_DASH)[[1]]
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378 if(length(lItemElement)>2){stop("Error in index, too many dashes, only one is allowed. Index = ",strIndexItem,sep="")}
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379
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380 #Switch names to numbers
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381 aiIndices = which(is.na(as.numeric(lItemElement)))
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382 for( iIndex in aiIndices )
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383 {
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384 lItemElement[iIndex] = which(cstrNames==lItemElement[iIndex])[1]
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385 }
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386
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387 #Make numeric
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388 liItemElement = unlist(lapply(lItemElement, as.numeric))
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389
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390 #If dash is at the end or the beginning add on the correct number
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391 if(substr(strIndexItem,1,1)==c_DASH){liItemElement[1]=2}
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392 if(substr(strIndexItem,nchar(strIndexItem),nchar(strIndexItem))==c_DASH){liItemElement[2]=length(cstrNames)}
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393
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394 #If multiple numbers turn to a slice
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395 if(length(liItemElement)==2){liItemElement = c(liItemElement[1]:liItemElement[2])}
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396
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397 #Update indices
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398 viRetIndicies = c(viRetIndicies, liItemElement)
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399 }
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400 if(length(viRetIndicies)==0){return(NA)}
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401 return(sort(unique(viRetIndicies)))
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402 ### Sorted indicies vector
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403 }
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