annotate test-data/NP_000548.2.hhr @ 0:d30785e31577 draft

"planemo upload commit 6eee67778febed82ddd413c3ca40b3183a3898f1"

Query         NP_000548.2
Match_columns 501
No_of_seqs    1691 out of 7065
Neff          7.55495
Searched_HMMs 400
Date          Sat Jul 25 00:10:29 2020
Command       /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000548.2.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000548.2.hhr 

 No Hit                             Prob E-value P-value  Score    SS Cols Query HMM  Template HMM
  1 5FFO_H Integrin alpha-V, Integ 100.0 2.3E-42 2.1E-46  353.3   0.0  315  143-501    24-363 (363)
  2 3RJR_C Transforming growth fac 100.0 3.4E-42 3.1E-46  351.8   0.0  315  143-501    24-363 (363)
  3 5VQF_C Transforming growth fac 100.0 3.4E-42 3.2E-46  351.8   0.0  315  143-501    24-363 (363)
  4 5NTU_A Growth/differentiation  100.0 9.5E-42 8.8E-46  343.8   0.0  309  142-501    17-335 (335)
  5 5HLY_A Inhibin beta A chain; G 100.0   3E-39 2.7E-43  332.7   0.0  307  142-501    40-383 (383)
  6 6SF3_B Serine/threonine-protei  99.8 1.5E-26 1.3E-30  194.7   0.0  105  397-501     4-108 (108)
  7 4MPL_A Growth/differentiation   99.8 2.3E-26   2E-30  196.3   0.0  106  396-501    10-116 (116)
  8 6Z3J_B Growth/differentiation   99.8 2.6E-26 2.3E-30  196.2   0.0  107  395-501    11-117 (117)
  9 5I05_A Growth/differentiation   99.8   4E-26 3.5E-30  192.9   0.0  106  396-501     4-110 (110)
 10 4N1D_A Bone morphogenetic prot  99.8 4.5E-26 3.9E-30  194.5   0.0  106  396-501    11-116 (116)
 11 2QCQ_B Bone morphogenetic prot  99.8 5.7E-26   5E-30  191.9   0.0  105  397-501     5-110 (110)
 12 1LXI_A BONE MORPHOGENETIC PROT  99.8   9E-26 7.8E-30  198.7   0.0  111  391-501    29-139 (139)
 13 6OMN_G Bone morphogenetic prot  99.8 9.8E-26 8.7E-30  189.8   0.0  105  396-501     4-108 (108)
 14 2R53_A Bone morphogenetic prot  99.8 9.9E-26 8.7E-30  192.3   0.0  106  396-501    11-116 (116)
 15 2R53_B Bone morphogenetic prot  99.8 9.9E-26 8.7E-30  192.3   0.0  106  396-501    11-116 (116)
 16 1REU_A bone morphogenetic prot  99.8 1.1E-25   1E-29  187.7   0.0  102  399-501     2-103 (103)
 17 1M4U_L Bone Morphogenetic Prot  99.8 1.2E-25 1.1E-29  197.8   0.0  111  391-501    29-139 (139)
 18 2H62_B Bone morphogenetic prot  99.8 2.1E-25 1.9E-29  189.6   0.0  105  396-501    10-114 (114)
 19 6Q2J_B Growth/differentiation   99.8 3.8E-25 3.2E-29  193.7   0.0  102  396-501    34-135 (135)
 20 1KTZ_A TRANSFORMING GROWTH FAC  99.8 7.5E-25 6.6E-29  185.6   0.0  102  395-501    10-112 (112)
 21 5TY4_B TGF-beta receptor type-  99.8 9.9E-25 8.8E-29  179.9   0.0   96  400-500     1-97  (97)
 22 5VT2_B Growth/differentiation   99.8 1.1E-24 9.5E-29  184.6   0.0  102  396-501    11-112 (112)
 23 5VZ3_A Growth/differentiation   99.8 1.1E-24 9.5E-29  184.6   0.0  102  396-501    11-112 (112)
 24 2ARP_A Inhibin beta A chain, F  99.8 1.3E-24 1.2E-28  184.9   0.0  105  397-501     8-116 (116)
 25 2ARV_A Inhibin beta A chain; h  99.8 1.3E-24 1.2E-28  184.9   0.0  105  397-501     8-116 (116)
 26 2P6A_B Activin A, Follistatin   99.8 1.3E-24 1.2E-28  184.9   0.0  105  397-501     8-116 (116)
 27 2TGI_A TRANSFORMING GROWTH FAC  99.8 1.5E-24 1.3E-28  183.7   0.0  101  396-501    11-112 (112)
 28 3HH2_B Growth/differentiation   99.8 2.4E-24 2.1E-28  181.5   0.0   99  396-501    11-109 (109)
 29 5F3B_C RK35 Chimeric antibody   99.8 2.4E-24 2.1E-28  181.5   0.0   99  396-501    11-109 (109)
 30 3KFD_D Transforming growth fac  99.8 3.7E-24 3.2E-28  181.3   0.0  102  395-501    10-112 (112)
 31 5E4G_A Growth/differentiation   99.8 1.2E-23 1.1E-27  177.0   0.0   99  396-501    11-109 (109)
 32 5NMZ_B Neurturin; cystine knot  99.7 2.2E-22 1.9E-26  167.0   0.0   93  397-501     4-101 (101)
 33 5NMZ_C Neurturin; cystine knot  99.7 2.2E-22 1.9E-26  167.0   0.0   93  397-501     4-101 (101)
 34 2GH0_C artemin, GDNF family re  99.7 2.9E-22 2.6E-26  166.0   0.0   95  398-501     2-100 (101)
 35 5MR4_B Neurturin, GDNF family   99.7 4.4E-22 3.9E-26  165.4   0.0   94  396-501     4-102 (102)
 36 2V5E_B GDNF FAMILY RECEPTOR AL  99.7 7.4E-22 6.6E-26  163.6   0.0   93  397-501     5-101 (101)
 37 2ASK_B artemin; Glial cell der  99.7 9.1E-22   8E-26  166.6   0.0   94  396-501    12-112 (113)
 38 3FUB_D GDNF family receptor al  99.7 9.6E-22 8.1E-26  171.2   0.0   96  394-501    35-134 (134)
 39 1AGQ_C GLIAL CELL-DERIVED NEUR  99.7 2.2E-21 1.8E-25  169.0   0.0   95  395-501    37-135 (135)
 40 5TX2_A Transforming growth fac  99.7 2.9E-21 2.5E-25  157.7   0.0   81  396-501    12-93  (93)
 41 5TX4_B TGF-beta receptor type-  99.7   3E-21 2.6E-25  157.3   0.0   81  396-501    11-92  (92)
 42 2GYZ_A neurotrophic factor art  99.6 1.4E-19 1.2E-23  150.9   0.0   89  399-497     1-97  (105)
 43 6Q2S_B Ubiquitin-like protein   99.5 2.9E-18 2.5E-22  163.2   0.0   93  397-501   135-234 (235)
 44 6GFF_E Transforming growth fac  98.9 1.1E-13   1E-17  131.1   0.0  158  143-316    22-193 (249)
 45 6GFF_G Transforming growth fac  98.9 1.1E-13   1E-17  131.2   0.0  158  143-316    22-193 (249)
 46 5HLZ_E Inhibin beta A chain; G  98.7 1.8E-12 1.6E-16  124.5   0.0  155  143-317    41-227 (270)
 47 4YCG_B pro-BMP9 prodomain, hum  98.7 3.5E-12 3.2E-16  124.4   0.0  152  143-316    41-208 (296)
 48 4YCI_B mouse pro-BMP9 prodomai  98.7 3.5E-12 3.2E-16  124.4   0.0  152  143-316    41-208 (296)
 49 4NT5_A von Willebrand factor;   75.7    0.27 2.4E-05   38.0   0.0   65  422-501    37-101 (107)
 50 2KD3_A Sclerostin; Protein, an  73.5    0.35   3E-05   38.0   0.0   73  419-501    39-112 (113)
 51 4YU8_A Neuroblastoma suppresso  70.0    0.48 4.1E-05   38.5   0.0   88  398-501    32-120 (139)
 52 2K8P_A Sclerostin; WNT SIGNALL  66.7    0.66 5.3E-05   39.9   0.0   74  419-501    71-144 (189)
 53 4JPH_D Gremlin-2; Cystine knot  65.1    0.72   6E-05   37.9   0.0   88  398-501    51-138 (148)
 54 4X1J_B Neuroblastoma suppresso  64.2    0.74 6.5E-05   35.8   0.0   88  398-501    17-105 (116)
 55 5AEJ_A GREMLIN-1; SIGNALING PR  62.6    0.87 7.2E-05   37.6   0.0   87  397-501    59-147 (152)
 56 5HK5_G Gremlin-2, Growth/diffe  61.9    0.91 7.6E-05   37.2   0.0   86  398-501    50-137 (147)
 57 5BPU_A Frizzled-4; Wnt signall  57.8     1.2  0.0001   35.0   0.0   72  422-501    37-108 (122)
 58 5BQ8_C Norrin; Wnt signalling   54.0     1.5 0.00013   34.3   0.0   93  398-501    16-108 (122)
 59 5BQE_A Frizzled-4; Wnt signall  54.0     1.5 0.00013   34.3   0.0   93  398-501    16-108 (122)

No 1
>5FFO_H Integrin alpha-V, Integrin beta-6, Transforming; Integrin, TGF-beta, CELL ADHESION; HET: MAN, NAG, BMA; 3.49A {Homo sapiens}
Probab=100.00  E-value=2.3e-42  Score=353.27  Aligned_cols=315  Identities=24%  Similarity=0.379  Sum_probs=194.7  Template_Neff=9.300

Q NP_000548.2     143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----N--SSVKLEAGLANTITSFIDKGQDDRG-P  215 (501)
Q Consensus       143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~--~~~~~~~~~~n~Vrsf~~~~~~~~~-~  215 (501)
                      .+||++|||+++|+.+..    .+.+++++|++||+.+........    .  ..+.+.....++++++......... .
T Consensus        24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~   99 (363)
T 5FFO_H           24 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ   99 (363)
T ss_dssp             HHHHHHTTCSSCCCSSSS----CSSCCCHHHHHHHHHHSCCCCC--------CCSSSSCEEEEEEECBCTTSSSTTTTCC
T ss_pred             HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHHHHhhccCCCCCCCCCCcccceeeeEEEEEEeecCccccccccc
Confidence            689999999999987642    223568999999998765431100    0  0011222234556666533221100 1


Q NP_000548.2     216 VVRKQRYVFDISA----LEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG  290 (501)
Q Consensus       216 ~~~~~~l~FnlSs----i~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g  290 (501)
                      ......++|++++    ++. +.|.+|+||||+.....           ...|.||..... ....+++++.+.....++
T Consensus       100 ~~~~~~~~F~is~~~~~~~~~~~v~~AeLrl~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~~  167 (363)
T 5FFO_H          100 STHSIYMFFQTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-NSWRYLSNRLLAPSDSPE  167 (363)
T ss_dssp             BTTEEEEEECSTTHHHHSCSGGGEEEEEEECCBCCCCS-----------CCEEEEEEEETT-TEEEEEEEEECCCCSSCC
T ss_pred             ccceEEEEEechhccccCCCchhhcHhhhHhhcCccCc-----------cEEEEEEEecCc-ccceeeEeEEeCCCCCCC
Confidence            2345678999997    433 57999999999887532           345677765421 111233333221234579


Q NP_000548.2     291 WEVFDIWKLFRNFKNSA--QLCLELEAWERG----RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI  358 (501)
Q Consensus       291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~~----~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~  358 (501)
                      |+.||||.+|+.|+.++  ++||.|.+....    ....+...++..      .......+|+|++++.+....      
T Consensus       168 W~~fdVt~~v~~W~~~~~~n~gl~v~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lv~~~~~~~~~------  241 (363)
T 5FFO_H          168 WLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERA------  241 (363)
T ss_dssp             CCEEECHHHHHHHHHSCCSCEEEEEEECCBTTTTBCCCCCCBSCCTTTCCSSGGGGGGTTCCEEEEEECCTTTC------
T ss_pred             eEEEEcHHHHHHHHHcCCccccEEEEEEecCCCCCCceeeeeccccCCcccchhhccccCCcEEEEEeCchHHH------
Confidence            99999999999999997  788886554311    111110101100      011124566666666432210      


Q NP_000548.2     359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL  437 (501)
Q Consensus       359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~  437 (501)
                          .        ..+.+++ ||+.   + ...+.......||+++++|+|+ ||||+ |||+|++|+||||.|.|+++.
T Consensus       242 ----~--------~~~~~r~-rr~~---~-~~~~~~~~~~~Cc~~~l~V~F~~~lgw~-~iiaP~~~~a~~C~G~C~~~~  303 (363)
T 5FFO_H          242 ----Q--------HLQSSRH-RRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW  303 (363)
T ss_dssp             ----C-------------------------------CCSSSSEEECCCBCHHHHTCCC-SEEECCCBCCCEEECCCCCSC
T ss_pred             ----H--------hhhHHhh-Hhhc---c-cCCCCCCCcccceeeEEEEEccHHhCCc-eeeCCCeEEeeeccCCCCCcc
Confidence                0        0000111 1110   1 1122233467899999999996 99998 999999999999999999997


Q NP_000548.2     438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ..   +++|+.++++++...+..++.|||+|++|++|+|||+|++ .++++.++||+|++|||+
T Consensus       304 ~~---~t~ha~i~~~~~~~~~~~~~~~CC~P~~~~~l~ily~d~~-~~~~~~~~~m~v~~CgC~  363 (363)
T 5FFO_H          304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS  363 (363)
T ss_dssp             SC---C-----CCSSCTTTCSSCCSSCCEEECCEEEEEEEECC-C-CCEEEEEEEEEECCEEEC
T ss_pred             cc---cccHHHHHHHHHhhCCCCCCCCCcccceeceeeEEEEeCC-eeEEEEecCcEEeccCCC
Confidence            63   5688988888776555568999999999999999999987 588999999999999995


No 2
>3RJR_C Transforming growth factor beta-1; TGF beta, activation, integrin, Cytokine; HET: NAG; 3.05A {Sus scrofa}
Probab=100.00  E-value=3.4e-42  Score=351.82  Aligned_cols=315  Identities=24%  Similarity=0.389  Sum_probs=198.8  Template_Neff=9.400

Q NP_000548.2     143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----NS--SVKLEAGLANTITSFIDKGQDDRG-P  215 (501)
Q Consensus       143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~~--~~~~~~~~~n~Vrsf~~~~~~~~~-~  215 (501)
                      .+||++|||+++|+....    .+.+++++|++||+.+........    ..  .+.+......+++++......... .
T Consensus        24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~   99 (363)
T 3RJR_C           24 GQILSKLRLASPPSQGDV----PPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKG   99 (363)
T ss_pred             HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHhhcccccCCcCCCCCCCcccccchhccceEeecCCcccccccCC
Confidence            689999999999987641    223568999999997654321100    00  001111122333333221110000 1


Q NP_000548.2     216 VVRKQRYVFDISAL----EK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG  290 (501)
Q Consensus       216 ~~~~~~l~FnlSsi----~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g  290 (501)
                      ......+.|+++++    +. +.|.+|+||||+.....           ...+.||..... ....++.++.+.....++
T Consensus       100 ~~~~~~~~F~~s~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~g  167 (363)
T 3RJR_C          100 TPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-DSWRYLSNRLLAPSDSPE  167 (363)
T ss_pred             CccEEEEEEEcccCCCCCCcchhceEEEEEEEeCCCCC-----------CceEEEEEecCh-hheeEEEEEEeccCCCCc
Confidence            13466899999974    22 47999999999887542           235667754321 111233333221234579


Q NP_000548.2     291 WEVFDIWKLFRNFKNSA--QLCLELEAWER--G--RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI  358 (501)
Q Consensus       291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~--~--~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~  358 (501)
                      |+.|||+.+|+.|+.++  ++||.|.+...  .  ..+.+...++..      .......+|+|++++.+....      
T Consensus       168 W~~fdVt~~v~~W~~~~~~n~gl~l~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lv~~~~~~~~~------  241 (363)
T 3RJR_C          168 WLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERA------  241 (363)
T ss_pred             EEEEECHHHHHHHHhCCcccCcEEEEEEEccCCCCceeeEEEccccCCCcCCcccccccCCCEEEEEEcCCccc------
Confidence            99999999999999997  78888655321  1  111111001100      001124566666666432210      


Q NP_000548.2     359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL  437 (501)
Q Consensus       359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~  437 (501)
                                  ...+.++ +||+.   + ...+.......||+++++|+|+ ||||+ |||+|++|+||||.|.|+++.
T Consensus       242 ------------~~~~~~r-~rr~~---~-~~~~~~~~~~~Ccr~~l~V~F~~~lgW~-wIiaP~~y~a~~C~G~C~~~~  303 (363)
T 3RJR_C          242 ------------QHLHSSR-HRRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW  303 (363)
T ss_pred             ------------ccccccc-ccccC---C-CCCCCCCCCCcccceeEEEecchhhCCc-eEecCCeEEeeeecccCCCCC
Confidence                        0000011 11110   1 1122223467899999999997 99997 999999999999999999997


Q NP_000548.2     438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ..   .++|+.++++++...+..++.|||+|++|++|+|||+|++ ++++++++||+|++|||+
T Consensus       304 ~~---~t~ha~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~-~~~~~~~~~mvv~~CgC~  363 (363)
T 3RJR_C          304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS  363 (363)
T ss_pred             CC---cCcHHHHHHHHHhcCCCCCCCCcccccccCceEEEEEcCC-cEEEEEeCCeEEeeccCC
Confidence            63   5689999988876555578999999999999999999987 588999999999999995


No 3
>5VQF_C Transforming growth factor beta-1; pro-complex, latency, homodimer, PROTEIN BINDING; HET: NAG, BMA; 2.9A {Sus scrofa}
Probab=100.00  E-value=3.4e-42  Score=351.78  Aligned_cols=315  Identities=24%  Similarity=0.389  Sum_probs=197.2  Template_Neff=9.400

Q NP_000548.2     143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG----NS--SVKLEAGLANTITSFIDKGQDDRG-P  215 (501)
Q Consensus       143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~----~~--~~~~~~~~~n~Vrsf~~~~~~~~~-~  215 (501)
                      .+||++|||+++|++...    .+.+++++|++||+.+........    ..  .+.+.....++++++......... .
T Consensus        24 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~   99 (363)
T 5VQF_C           24 GQILSKLRLASPPSQGDV----PPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKG   99 (363)
T ss_dssp             HHHHHHTTCSSCCCCTTC----CCSCCCHHHHHHHHHHHCCCBCC-------CCCCSSCEEEEEEECCCSSSSTTTSSTT
T ss_pred             HHHHHHcCCCCCCCCCCC----CCCCCCHHHHHHHHHHhhhcCCCCCCCCCCChhhheeeEEEEEEEeecCCceecccCC
Confidence            689999999999987641    223568999999997655421100    00  001111122333333221110000 1


Q NP_000548.2     216 VVRKQRYVFDISAL----EK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG  290 (501)
Q Consensus       216 ~~~~~~l~FnlSsi----~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g  290 (501)
                      ......+.|+++++    +. +.|.+|+||||+.....           ...+.||..... ....++.++.+.....++
T Consensus       100 ~~~~~~l~F~~s~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~-~~~~~~~~~~~~~~~~~g  167 (363)
T 5VQF_C          100 TPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSQ-DSWRYLSNRLLAPSDSPE  167 (363)
T ss_dssp             CTTEEEEEEEHHHHHHHCSSGGGEEEEEEEEEECCCSS-----------CEEEEEEEECSS-SCEEEEEEEEECCCSSCE
T ss_pred             CCCeEEEEEEhhhccccCCCccceeeeEEEEEEcCCcc-----------ceEEEEEEecCc-ccceeEEeEEeCCCCCCC
Confidence            13466899999974    22 47999999999887542           245667754321 111233333221234579


Q NP_000548.2     291 WEVFDIWKLFRNFKNSA--QLCLELEAWER--G--RAVDLRGLGFDR------AARQVHEKALFLVFGRTKKRDLFFNEI  358 (501)
Q Consensus       291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~~~--~--~~~~v~~~~~~~------~~~~~~~~ppLLv~~~~~~~~~~~~~~  358 (501)
                      |+.|||+.+|+.|+.++  +++|.|.+...  .  ..+.+...++..      .......+|+|++++.+....      
T Consensus       168 W~~fdvt~~v~~W~~~~~~n~gl~l~v~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~P~Lvi~~~~~~~~------  241 (363)
T 5VQF_C          168 WLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERA------  241 (363)
T ss_dssp             EEEEECHHHHHHHHHCCCSEEEEEEEECEEEEEETTEEEEEEC------CCCSBCCSSTTCCEEEEEECCSTTT------
T ss_pred             eEEEEcHHHHHHHHhhchhcCCEEEEEEeecCCCCCceeeEEccccCCCccchhhccccCCcEEEEEEChhHHh------
Confidence            99999999999999997  78888655321  1  111111001100      001124566666666432110      


Q NP_000548.2     359 KARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPL  437 (501)
Q Consensus       359 ~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~  437 (501)
                                  ...+.++ +||+.   . ...+.......||+++++|+|+ ||||| |||+|++|+||||.|.|+++.
T Consensus       242 ------------~~~~~~r-~rr~~---~-~~~~~~~~~~~Ccr~~l~V~F~~~lgWd-wIiaP~~y~a~~C~G~C~~~~  303 (363)
T 5VQF_C          242 ------------QHLHSSR-HRRAL---D-TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW  303 (363)
T ss_dssp             ------------CC---------CE---E-HHHHTTSCCSSSEEECCEEETTTTTCCC-CEEECSEEECCEEECCCCCTT
T ss_pred             ------------hccchhh-hhhcc---C-cCccCCCCCccceeeEEEEEcchhhCCc-eeeCCCeEEeEeecCCCCCcC
Confidence                        0000011 11110   1 1122223467899999999997 99997 999999999999999999997


Q NP_000548.2     438 RSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       438 ~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ..   .++|+.++++++...+..++.|||+|++|++|+|||+|++ +++++.++||+|++|||+
T Consensus       304 ~~---~t~ha~v~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~-~~~~~~~~~miv~~CgC~  363 (363)
T 5VQF_C          304 SL---DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR-KPKVEQLSNMIVRSCKCS  363 (363)
T ss_dssp             TS---CSCCHHHHTGGGGCCGGGSSSCCEEESSEEEEEEEEEETT-EEEEEEEEEEEECEEEEC
T ss_pred             Cc---cccHHHHHHHHHhcCCCCCCCCCccCcccceeeEEEEECC-eeEEEEecCcEEeccCCC
Confidence            63   5689999988876555578999999999999999999987 588999999999999995


No 4
>5NTU_A Growth/differentiation factor 8; growth factor, signalling protein, TGFbeta; HET: EDO; 2.58A {Homo sapiens}
Probab=100.00  E-value=9.5e-42  Score=343.78  Aligned_cols=309  Identities=22%  Similarity=0.402  Sum_probs=196.1  Template_Neff=9.900

Q NP_000548.2     142 SSFLLKKAREPGPPREPKEPFR-P-PPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRK  219 (501)
Q Consensus       142 ~~qIL~kLGL~~~P~~~~~~~~-~-~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~~~~~~  219 (501)
                      -.+||++|||+++|++....++ . +..+++++|+++|+.+....... ...++++...+++|++|..............
T Consensus        17 k~~IL~~LgL~~~P~~~~~~~~~~~~~~~~~~~l~~~y~~~~~~~~~~-~~~~~~~~~~~~~v~~f~~~~~~~~~~~~~~   95 (335)
T 5NTU_A           17 KIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDG-SLEDDDYHATTETIITMPTESDFLMQVDGKP   95 (335)
T ss_pred             HHHHHHHcCCCCCCCCCCCCCcccCCCCCchHHHHHHHhhccCCCCCC-CCcccchhcccceEEEeccCCCcccCCCCCC
Confidence            4689999999999998763110 0 11225799999999765432110 0011223345567888865432210001245


Q NP_000548.2     220 QRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR---QPAALLDVRSVP-GLDGSGWEVF  294 (501)
Q Consensus       220 ~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~---~~~~ll~s~~v~-~~~~~gWv~f  294 (501)
                      ..++|+++++.. +.|.+|+||||+......         ....+.||......   .....+....+. ....++|++|
T Consensus        96 ~~~~F~ls~~~~~~~v~~AeL~l~~~~~~~~---------~~~~v~vy~v~~~~~~~~~~~~~~~~~~~~~~~~~gW~~f  166 (335)
T 5NTU_A           96 KCCFFKFSSKIQYNKVVKAQLWIYLRPVETP---------TTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSI  166 (335)
T ss_pred             eEEEEECCCCCCCcceeEEEEEEEECCCCCC---------CeEEEEEEEEEccCcCCceeeeeeEEEEEccCCCCcEEEE
Confidence            678999997654 589999999999875431         13456666543210   000011111111 1234699999


Q NP_000548.2     295 DIWKLFRNFKNSA--QLCLELEAWERG-RAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYE  371 (501)
Q Consensus       295 DVT~aV~~Wl~~~--nlgL~V~~~~~~-~~~~v~~~~~~~~~~~~~~~ppLLv~~~~~~~~~~~~~~~~~~~~~~~~~~~  371 (501)
                      |||.+|++|+.++  ++||.|.+...+ ....+   .+.... ....+|+|++++.+..                     
T Consensus       167 dVt~~v~~W~~~~~~n~gl~v~~~~~~~~~~~~---~~~~~~-~~~~~P~Lvi~~~~~~---------------------  221 (335)
T 5NTU_A          167 DVKTVLQNWLAAPASNLGIEIKALDENGHDLAV---TFPGPG-EDGLNPFLEVKVTDTP---------------------  221 (335)
T ss_pred             EcHHHHHHHHHCCccCceEEEEEEeCCCCeEee---ecCCCC-CcccCcEEEEEecCCC---------------------
Confidence            9999999999986  789988775432 11111   111111 1234555555542110                     


Q NP_000548.2     372 YLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQT  451 (501)
Q Consensus       372 ~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~  451 (501)
                          .++ +|.    ....|........||+++++|+|+||||+ |||+|++|+||||.|.|+++....   ++|+.   
T Consensus       222 ----~~~-~r~----~~~~~~~~~~~~~Ccr~~l~V~F~~igW~-wIiaP~~y~a~~C~G~C~~~~~~~---~~~~~---  285 (335)
T 5NTU_A          222 ----KRS-RRD----FGLDCDEHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLAA---YPHTH---  285 (335)
T ss_pred             ----ccc-ccc----CCCCCCCCCCCCCceeeEEEEEHHHcCCc-eeecCCeEEeEeeCccCCCCcccc---CCCch---
Confidence                111 111    10123233357899999999999999998 999999999999999999998642   24442   


Q NP_000548.2     452 LMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       452 ~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +++...+...+.|||+|++|++|+|||+|++++++++.++||+|++|||+
T Consensus       286 ~~~~~~~~~~~~pCC~P~~~~~l~ily~~~~~~i~~~~~~~mvv~~CgC~  335 (335)
T 5NTU_A          286 LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS  335 (335)
T ss_pred             hHhccCCCCCCCCcccceeccceEEEEECCCCCEEEEEeCCceeeccccC
Confidence            23333333578999999999999999999887889999999999999995


No 5
>5HLY_A Inhibin beta A chain; Growth factor, Precursor, Signalling, Signaling; HET: MSE; 2.302A {Homo sapiens}
Probab=100.00  E-value=3e-39  Score=332.69  Aligned_cols=307  Identities=21%  Similarity=0.407  Sum_probs=167.2  Template_Neff=8.800

Q NP_000548.2     142 SSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKG------GN----SSVKLEAGLANTITSFIDKGQD  211 (501)
Q Consensus       142 ~~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~------~~----~~~~~~~~~~n~Vrsf~~~~~~  211 (501)
                      =.+||++|||+++|+++..    .  +.+..+..+|+.+.......      .+    .+.+.+...++.|+.|....  
T Consensus        40 K~~IL~kLgL~~~P~~~~~----~--p~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~t~~ii~f~~~~--  111 (383)
T 5HLY_A           40 KKHILNMLHLKKRPDVTQP----V--PKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESG--  111 (383)
T ss_dssp             HHHHHHHTTCSSCCCCCCC----S--CHHHHHHHHHHTTSEEECGGGCEEETTCHHHHHHHHHHHHTEEEEEEECEEC--
T ss_pred             HHHHHHHcCCCCCCCCCCC----C--CCHHHHHHHHHhhcCCCCCCCcccccCCCCCCCCccccccceeEEEEECcCC--
Confidence            3689999999999998752    1  11222234565443211000      00    00112223456666665432  


Q NP_000548.2     212 DRGPVVRKQRYVFDISALE-K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR-----------------  272 (501)
Q Consensus       212 ~~~~~~~~~~l~FnlSsi~-~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~-----------------  272 (501)
                           .....++|++++.+ . +.|.+||||||+.......      ......|.||......                 
T Consensus       112 -----~~~~~l~F~iS~~~~~~~~V~~AeL~l~~~~~~~~~------~~~~~~V~vy~~~~~~~~~~~~~~~~~~~~~~~  180 (383)
T 5HLY_A          112 -----TARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANR------TRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKG  180 (383)
T ss_dssp             -----SSTTEEEEHCCE-------EEEEEEEEEEECS----------------------------------SC----CEC
T ss_pred             -----CCeEEEEEEcCCCCCCcceeEEEEEEEEecCCCCCC------CCceEEEEEEEEecCCCCCCCCcchhHhhcCCc
Confidence                 13567899999754 2 4699999999998764320      1124567777543210                 


Q NP_000548.2     273 -QPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSA--QLCLELEAWERGR-AVDLRGLGFDRAARQVHEKALFLVFGRT  348 (501)
Q Consensus       273 -~~~~ll~s~~v~~~~~~gWv~fDVT~aV~~Wl~~~--nlgL~V~~~~~~~-~~~v~~~~~~~~~~~~~~~ppLLv~~~~  348 (501)
                       ....++.++.+ ....++|++||||.+|+.|+.++  +++|.|.+..... ...+   ...........+|+|++++.+
T Consensus       181 ~~~~~l~~s~~i-~~~~~gWi~fdVt~~V~~Wl~~~~~n~gl~v~~~~~~~~~~~l---~~~~~~~~~~~~P~Lvi~~~~  256 (383)
T 5HLY_A          181 ERSELLLSEKVV-DARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASL---VLLGEEKEQSHRPFLMLQARQ  256 (383)
T ss_dssp             CEEEEEEEEEEE-ECSSCEEEEEECHHHHHHHHHTTCCEEEEEEECTTTTTTTCEE---ECSCCGGGGGGCCEEEEEEEC
T ss_pred             ccceEEEEEEEE-eCCCCcEEEEEcHHHHHHHHhCCccCcceEEEEEcCCCCCceE---EEecCCCccccccEEEEEEcC
Confidence             00112333333 23457999999999999999987  7888877653221 1101   000011112356666666532


Q NP_000548.2     349 KKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFH  428 (501)
Q Consensus       349 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~r~~rr~~~~~~~~~~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~y  428 (501)
                      ...                      . +++++++    . ..|  ......||+++++|+|+||||++|||+|++|+|+|
T Consensus       257 ~~~----------------------~-~~rr~~~----~-~~~--~~~~~~Cc~~~~~V~F~~lgw~~wIiaP~~y~a~~  306 (383)
T 5HLY_A          257 SED----------------------H-PHRRRRR----G-LEC--DGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANY  306 (383)
T ss_dssp             C-------------------------------------C-CBC--SSCSSBCEEECCEEETTTTTCTTTEEECSEEECCE
T ss_pred             ccc----------------------c-ccccccc----C-CCC--CCCCcccccceeeecHHHhCCcceeecCCEEEcee
Confidence            110                      0 0111111    0 112  12468999999999999999988999999999999


Q NP_000548.2     429 CEGLCEFPLRSHLE--PTNHAVIQTLMNS--MDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       429 C~G~C~~~~~~~~~--~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |.|.|+.+.....+  .++|+.+...+..  ..+...+.|||+|++|++++|||+|++++++++.++||+|++|||+
T Consensus       307 C~G~C~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~pCC~P~~~~~l~ily~~~~~~i~~~~~~~mvv~~CgC~  383 (383)
T 5HLY_A          307 CEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS  383 (383)
T ss_dssp             EESBCC---------C---SCCC---------------CCCEEEEEEEEEEEEEES-SSCEEEEEEEEEEEEEEEEC
T ss_pred             ecccCCCCCCCCCCCcccHHHHHHHHHHhcCCCCCcCCCCcccccccCceEEEEEcCCCcEEEEEeCCcEEeecccC
Confidence            99999998653211  1235433332211  1123568999999999999999999987889999999999999995


No 6
>6SF3_B Serine/threonine-protein kinase receptor R3 (E.C.2.7.11.30); BMP10, ALK1, complex, signalling, TGFbeta; 2.3000067422A {Homo sapiens}
Probab=99.85  E-value=1.5e-26  Score=194.74  Aligned_cols=105  Identities=48%  Similarity=1.049  Sum_probs=89.1  Template_Neff=8.600

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISI  476 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~i  476 (501)
                      ...||+++++|+|+||||++|||+|++|+++||.|.|..+....++.++|+.++.+++...+.....|||+|++|++++|
T Consensus         4 ~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~i   83 (108)
T 6SF3_B            4 GNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISI   83 (108)
T ss_dssp             -CBSEEECCEEETTTTTGGGTEEECSEEECCEEESBBCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCBCEEEEEEEEEEE
T ss_pred             CCcceEEEeEeeHHHhCCCceeeCCCceeceeeccccCCCCCCCCCCCchHHHHHHHHhhCccccCCCcccceecCceEE
Confidence            56899999999999999988999999999999999999987643334578877776654434467899999999999999


Q NP_000548.2     477 LFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       477 ly~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ||+++++.++.+.++||+|++|||+
T Consensus        84 l~~~~~~~~~~~~~~~~~v~~C~C~  108 (108)
T 6SF3_B           84 LYLDKGVVTYKFKYEGMAVSECGCR  108 (108)
T ss_dssp             EEEETTEEEEEEEEEEEEEEEEEEC
T ss_pred             EEEECCeeEEEEEECCeEEeecccC
Confidence            9999875555678999999999995


No 7
>4MPL_A Growth/differentiation factor 2; growth factor/cytokine, CYTOKINE; 1.9A {Homo sapiens}
Probab=99.84  E-value=2.3e-26  Score=196.32  Aligned_cols=106  Identities=50%  Similarity=1.028  Sum_probs=90.4  Template_Neff=7.900

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++|++++
T Consensus        10 ~~~~C~~~~l~V~F~dlgw~~~Ii~P~~~~~~yC~G~C~~~~~~~~~~t~ha~i~~~~~~~~~~~~~~~CC~P~~~~~l~   89 (116)
T 4MPL_A           10 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS   89 (116)
T ss_dssp             CCCCCEEECCEEETTTTTCTTTEEECSEEECCEEESCCCSSCCTTCCCCHHHHHHHHHHHHSTTTSCCCCEEEEEEEEEE
T ss_pred             CCCCCEEEEEEEeHHHhCCCCCeeCCCeeEeEEEcccCCCCCCCCCCCCchHHHHHHHhhcCCccCCCCceeeeEecCeE
Confidence            35789999999999999998899999999999999999998765333457787777665443446789999999999999


Q NP_000548.2     476 ILFIDSANNVVYK-QYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~-~~~~mvv~~CgC~  501 (501)
                      |||+++++.++++ .++||+|++|+|+
T Consensus        90 ily~~~~~~~~~~~~~~~mvv~~CgC~  116 (116)
T 4MPL_A           90 VLYKDDMGVPTLKYHYEGMSVAECGCR  116 (116)
T ss_dssp             EEEECSSSCEEEEEEEEEEEEEEEEEC
T ss_pred             EEEECCCCcEEEEEEECCeEEeccccC
Confidence            9999988666666 8999999999995


No 8
>6Z3J_B Growth/differentiation factor 5, RGM domain; Repulsive Guidance Molecule, RGM, Bone; HET: SO4, GOL, NAG, EDO; 1.65A {Homo sapiens}
Probab=99.84  E-value=2.6e-26  Score=196.21  Aligned_cols=107  Identities=98%  Similarity=1.618  Sum_probs=92.0  Template_Neff=8.300

Q NP_000548.2     395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI  474 (501)
Q Consensus       395 ~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l  474 (501)
                      .....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++...+.....|||+|++|+++
T Consensus        11 ~~~~~Cc~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~~~~~~~~~~~~~~cC~P~~~~~l   90 (117)
T 6Z3J_B           11 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI   90 (117)
T ss_dssp             -CCCBSEEECCEEETTTTTGGGTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEE
T ss_pred             CCCCcceeEEEEEeHHHcCCCccEEcCCeeeceeeeecCCCCccccCCCChHHHHHHHHHhcCCCCCCCCcccceeecce
Confidence            34789999999999999999889999999999999999999876433345788777766544445678999999999999


Q NP_000548.2     475 SILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       475 ~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +|+|+++++.++++.++||+|++|||+
T Consensus        91 ~ily~~~~~~~~~~~~~~~~v~~CgC~  117 (117)
T 6Z3J_B           91 SILFIDSANNVVKKDYEDMVVESCGCR  117 (117)
T ss_dssp             EEEEECTTSCEEEEEEEEEEEEEEEEC
T ss_pred             EEEEEcCCCcEEEEEECCeEEeeccCC
Confidence            999999877788999999999999995


No 9
>5I05_A Growth/differentiation factor 2; GROWTH DIFFERENTIATION FACTOR 2, CELL; HET: GOL; 1.87A {Homo sapiens}
Probab=99.84  E-value=4e-26  Score=192.88  Aligned_cols=106  Identities=50%  Similarity=1.028  Sum_probs=90.1  Template_Neff=8.400

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|+||||++|||+|++|+++||.|.|..+....++.++|+.++.+++...+.....|||+|++|++++
T Consensus         4 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~   83 (110)
T 5I05_A            4 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS   83 (110)
T ss_dssp             CCCBSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
T ss_pred             CCCcceeEEEEEeHHHhCCCCcEeCCCccccEeecCCCCCCCCCCCCCChhHHHHHHHhhcCCCCCCCcccceeeecceE
Confidence            35789999999999999998899999999999999999998764333457777776655443456789999999999999


Q NP_000548.2     476 ILFIDSANNVVYK-QYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~-~~~~mvv~~CgC~  501 (501)
                      |||+|++++++++ .++||+|++|||+
T Consensus        84 il~~~~~~~~~~~~~~~dm~v~~CgC~  110 (110)
T 5I05_A           84 VLYKDDMGVPTLKYHYEGMSVAECGCR  110 (110)
T ss_dssp             EEEECTTSCEEEEEEEEEEEEEEEEEC
T ss_pred             EEEECCCCcEEEEEEeCCeEEeecccC
Confidence            9999998766666 8999999999995


No 10
>4N1D_A Bone morphogenetic protein 2; Cytokine, Signaling Protein; 1.912A {Homo sapiens}
Probab=99.84  E-value=4.5e-26  Score=194.45  Aligned_cols=106  Identities=52%  Similarity=1.077  Sum_probs=90.5  Template_Neff=8.300

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++...+.....|||+|++|++++
T Consensus        11 ~~~~Cc~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~   90 (116)
T 4N1D_A           11 LKSSCKRHPLYVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCVPTELSAIS   90 (116)
T ss_dssp             -C-BSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
T ss_pred             CCCcceeEEEEEEHHHhCCCCCEeCCCeeeceeeeEeCCCCCccCCCCChhHHHHHHHHhcCCCCCCCCceecceecceE
Confidence            46789999999999999998899999999999999999988764333457887777765444446789999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|+++++.++++.++||+|.+|||+
T Consensus        91 il~~~~~~~~~~~~~~~~~v~~C~C~  116 (116)
T 4N1D_A           91 MLYLDENEKVVLKNYQDMVVEGCGCR  116 (116)
T ss_dssp             EEEECTTCCEEEEEEEEEEEEEEEEC
T ss_pred             EEEECCCCcEEEEEeCCeEEeccccC
Confidence            99999877788999999999999995


No 11
>2QCQ_B Bone morphogenetic protein 3; BMP, TGF-beta, SIGNALING PROTEIN; 2.21A {Homo sapiens}
Probab=99.83  E-value=5.7e-26  Score=191.87  Aligned_cols=105  Identities=46%  Similarity=1.054  Sum_probs=89.3  Template_Neff=8.500

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD-PESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~-~~~~~~pCC~P~~~~~l~  475 (501)
                      ...||+++++|+|+||||++|||+|++|+++||.|+|..+.....+.++|+.++.+++... ......|||+|++|++++
T Consensus         5 ~~~Cc~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~~~CC~P~~~~~l~   84 (110)
T 2QCQ_B            5 PRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLS   84 (110)
T ss_dssp             CSBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCGGGCCCHHHHHHHHHHHSSCSTTCCCCCEEESSEEEEE
T ss_pred             CCcceeeEEEEeHHHhCCCcceeCCCeecceeeceeCCCCCCccCCCCcHHHHHHHHHHhCCCCCCCCCceeeEEeCceE
Confidence            4689999999999999998899999999999999999998754333457777777655332 134679999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |||++++++++++.++||+|++|||+
T Consensus        85 il~~~~~~~~~~~~l~~~~v~~CgC~  110 (110)
T 2QCQ_B           85 ILFFDENKNVVLKVYPNMTVESCACR  110 (110)
T ss_dssp             EEEECTTCCEEEEEEEEEEECCEEEC
T ss_pred             EEEEcCCCcEEEEEECCeEEeccccC
Confidence            99999887788899999999999995


No 12
>1LXI_A BONE MORPHOGENETIC PROTEIN 7; Cystine-knot growth factor, HORMONE-GROWTH FACTOR; HET: NAG; 2.0A {Homo sapiens} SCOP: g.17.1.2
Probab=99.83  E-value=9e-26  Score=198.70  Aligned_cols=111  Identities=48%  Similarity=1.063  Sum_probs=90.2  Template_Neff=7.500

Q NP_000548.2     391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR  470 (501)
Q Consensus       391 ~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~  470 (501)
                      +........||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++
T Consensus        29 ~~~~~~~~~C~~~~~~V~f~~igw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~i~~l~~~~~~~~~~~~CC~P~~  108 (139)
T 1LXI_A           29 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQ  108 (139)
T ss_dssp             -------CBSEEECCEEEHHHHTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTCCCCCEEEEE
T ss_pred             cCCccccccceeeeeeccHHHhCCCCceecCCceeeeEecccCCCCcccccCCCHHHHHHHHHHhhCCCCCCCCceeeee
Confidence            33445678999999999999999988999999999999999999887543234577777776654434467899999999


Q NP_000548.2     471 LSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       471 ~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |++++|||+++++.++++.++||+|++|||+
T Consensus       109 ~~~l~ily~d~~~~i~~~~l~~mvv~~CgC~  139 (139)
T 1LXI_A          109 LNAISVLYFDDSSNVILKKYRNMVVRACGCH  139 (139)
T ss_dssp             EEEEEEEEECTTSCEEEEEEEEEEEEEEEEC
T ss_pred             eCceEEEEECCCCCEEEEEEcCeEEecccCC
Confidence            9999999999877788999999999999995


No 13
>6OMN_G Bone morphogenetic protein 2; BMP, Bone Mophogenetic Protein, CYTOKINE; HET: BMA, MAN, NAG; 2.68A {Homo sapiens}
Probab=99.83  E-value=9.8e-26  Score=189.80  Aligned_cols=105  Identities=57%  Similarity=1.165  Sum_probs=89.4  Template_Neff=8.400

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... ...+.|||+|++|++++
T Consensus         4 ~~~~Cc~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~-~~~~~~CC~P~~~~~l~   82 (108)
T 6OMN_G            4 LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAIS   82 (108)
T ss_pred             CCCCcEEEEeEEehHHcCCCccEECCCeeeeEEEcccCCCCCccccCCCchHHHHHHHhcCC-CCCCCCceeEEeeCceE
Confidence            35789999999999999998899999999999999999988654333456777776654432 35689999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |||+++++.++++.++||+|++|||+
T Consensus        83 ily~~~~~~~~~~~~~~m~v~~CgC~  108 (108)
T 6OMN_G           83 MLYLDENEKVVLKNYQDMVVEGCGCR  108 (108)
T ss_pred             EEEECCCCcEEEEEeCCeEEeccccC
Confidence            99999877788999999999999995


No 14
>2R53_A Bone morphogenetic protein 6; BMP6, Vgr, TGF-beta ligand, Chondrogenesis; HET: MPD; 2.1A {Homo sapiens}
Probab=99.83  E-value=9.9e-26  Score=192.30  Aligned_cols=106  Identities=49%  Similarity=1.068  Sum_probs=89.6  Template_Neff=8.200

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++.........|||+|++|++++
T Consensus        11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~   90 (116)
T 2R53_A           11 RLKACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAIS   90 (116)
T ss_dssp             CSSBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCTTTTSCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
T ss_pred             ccCceEEEEEEEeHHHhCCCCcEecCCeEEeEEeceeCCCCCccccCCChHHHHHHHHHhcCCccCCCCeeeeeecCCeE
Confidence            36799999999999999998799999999999999999998654323456777666554433345789999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|+++++.+++++++||+|++|||.
T Consensus        91 il~~~~~~~~~~~~l~~~~v~~C~C~  116 (116)
T 2R53_A           91 VLYFDDNSNVILKKYRNMVVRACGCH  116 (116)
T ss_dssp             EEEECTTCCEEEEEEEEEEEEEEEEC
T ss_pred             EEEECCCCcEEEEEEcCeEEecccCC
Confidence            99999877788899999999999995


No 15
>2R53_B Bone morphogenetic protein 6; BMP6, Vgr, TGF-beta ligand, Chondrogenesis; HET: MPD; 2.1A {Homo sapiens}
Probab=99.83  E-value=9.9e-26  Score=192.30  Aligned_cols=106  Identities=49%  Similarity=1.068  Sum_probs=89.6  Template_Neff=8.200

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++.........|||+|++|++++
T Consensus        11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l~   90 (116)
T 2R53_B           11 RLKACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAIS   90 (116)
T ss_dssp             CSSBSEEECCEEEHHHHTCTTTEEECSEEECCEEESBCCSSCCGGGCCCHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
T ss_pred             ccCceEEEEEEEeHHHhCCCCcEecCCeEEeEEeceeCCCCCccccCCChHHHHHHHHHhcCCccCCCCeeeeeecCCeE
Confidence            36799999999999999998799999999999999999998654323456777666554433345789999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|+++++.+++++++||+|++|||.
T Consensus        91 il~~~~~~~~~~~~l~~~~v~~C~C~  116 (116)
T 2R53_B           91 VLYFDDNSNVILKKYRNMVVRACGCH  116 (116)
T ss_dssp             EEEECTTSCEEEEEEEEEEEEEEEEC
T ss_pred             EEEECCCCcEEEEEEcCeEEecccCC
Confidence            99999877788899999999999995


No 16
>1REU_A bone morphogenetic protein 2; TGF-beta fold, HORMONE-GROWTH FACTOR COMPLEX; HET: MPD; 2.65A {Homo sapiens} SCOP: g.17.1.2
Probab=99.83  E-value=1.1e-25  Score=187.67  Aligned_cols=102  Identities=56%  Similarity=1.151  Sum_probs=87.5  Template_Neff=8.600

Q NP_000548.2     399 RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILF  478 (501)
Q Consensus       399 ~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily  478 (501)
                      .||+++++|+|+||||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... ...+.|||+|++|++++|||
T Consensus         2 ~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~~i~~~~~~~~-~~~~~~cC~P~~~~~l~ily   80 (103)
T 1REU_A            2 SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPPADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAISMLY   80 (103)
T ss_dssp             BSEEECCEEETTTTTCTTTCCBCSEEECCEEECBCCSSCCSSSCBCHHHHHHHHHHHHC-SSSCCCCEEEEEEEEEEEEE
T ss_pred             CceEEEeEecHHHcCCCCcEeCCCeecceEEeeeCCCCCcccCCCChhHHHHHHHhhcC-CCCCCccceeeEeCceEEEE
Confidence            69999999999999998899999999999999999998754333456777776654332 35689999999999999999


Q NP_000548.2     479 IDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       479 ~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ++++++++++.++||+|++|||+
T Consensus        81 ~~~~~~~~~~~~~~~~v~~CgC~  103 (103)
T 1REU_A           81 LDENEKVVLKNYQDMVVEGCGCR  103 (103)
T ss_dssp             ECTTCCEEEEEEEEEEEEEEEEC
T ss_pred             EcCCCcEEEEEeCCeEEeccccC
Confidence            99877788999999999999995


No 17
>1M4U_L Bone Morphogenetic Protein-7/Noggin; NOGGIN, BMP ANTAGONIST, BMP-7, BONE; HET: NAG; 2.42A {Homo sapiens} SCOP: g.17.1.2
Probab=99.82  E-value=1.2e-25  Score=197.81  Aligned_cols=111  Identities=48%  Similarity=1.063  Sum_probs=88.2  Template_Neff=7.500

Q NP_000548.2     391 RPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTR  470 (501)
Q Consensus       391 ~~~~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~  470 (501)
                      +........||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|++++.+++...+.....|||+|++
T Consensus        29 ~~~~~~~~~C~~~~~~V~f~~igw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~l~~l~~~~~~~~~~~pCC~P~~  108 (139)
T 1M4U_L           29 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQ  108 (139)
T ss_dssp             ---------SEEECCEEESGGGTCTTTEEECSEEECCEEECBCCSSEEGGGCCCHHHHHHHHHHHHCTTSSCCCCEEEEE
T ss_pred             ccCCCCCCcccceecccCHHHhCCCCceecCCeecceeecccCCCCCccccCCCHHHHHHHHHHhcCCCCCCCCceeeee
Confidence            33445678999999999999999988999999999999999999887533234577777776654434467899999999


Q NP_000548.2     471 LSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       471 ~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |++++|||+++++.++++.++||+|++|||+
T Consensus       109 ~~~l~ily~d~~~~i~~~~l~~mvv~~CgC~  139 (139)
T 1M4U_L          109 LNAISVLYFDDSSNVILKKYRNMVVRACGCH  139 (139)
T ss_dssp             EEEEEEEEECTTSCEEEEEEEEEEEEEEEES
T ss_pred             cCCeEEEEECCCCCEEEEEECCeEEeccccC
Confidence            9999999999877788999999999999995


No 18
>2H62_B Bone morphogenetic protein 2, Bone; TGF-beta superfamily, ligand-receptor complex, HORMONE-GROWTH; 1.85A {Homo sapiens} SCOP: g.17.1.2
Probab=99.82  E-value=2.1e-25  Score=189.59  Aligned_cols=105  Identities=57%  Similarity=1.165  Sum_probs=88.7  Template_Neff=8.300

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|++|||++|||+|++|+++||.|.|..+.....+.++|+.++.+++... .....|||+|++|++++
T Consensus        10 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~t~h~~~~~~~~~~~-~~~~~~CC~P~~~~~l~   88 (114)
T 2H62_B           10 LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAIS   88 (114)
T ss_dssp             --CBSEEECCEEEGGGTTCTTTEEECSEEECCEEECBCCSSCCGGGCCCHHHHHHHHHHHHC-TTSCCCCEEEEEEEEEE
T ss_pred             ccCcceEEEEEEehHHcCCCCcEeCCCeeeceEEeeeCCCCCccccCCCchHHHHHHHHhcC-CCCCCccceeeEeCceE
Confidence            46789999999999999998899999999999999999988754333456777776654332 35689999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|+|++++++++.++||+|++|+|+
T Consensus        89 ily~~~~~~~~~~~~~~~~v~~C~C~  114 (114)
T 2H62_B           89 MLYLDENEKVVLKNYQDMVVEGCGCR  114 (114)
T ss_dssp             EEEEETTTEEEEEEEEEEEEEEEEEC
T ss_pred             EEEECCCCcEEEEEeCCeEEeccccC
Confidence            99999877788999999999999995


No 19
>6Q2J_B Growth/differentiation factor 15, GDNF family; RET, receptor tyrosine kinase, cryo-EM; HET: NAG; 4.1A {Homo sapiens}
Probab=99.81  E-value=3.8e-25  Score=193.68  Aligned_cols=102  Identities=27%  Similarity=0.754  Sum_probs=85.9  Template_Neff=7.400

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....|++++++|+|+||||++|||+|++|+++||.|.|..+...   .++|+.++.+++...+..+..|||+|++|++++
T Consensus        34 ~~~cC~~~~~~V~F~dlGw~~wIi~P~~~~~~~C~G~C~~~~~~---~t~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  110 (135)
T 6Q2J_B           34 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV  110 (135)
T ss_pred             CcCcceeEEEEEeHHHcCCCCcEECCCeEEeEEecccCCCCCCC---CChHHHHHHHHHhcCCCCCCCCceeeeeecceE
Confidence            34445458999999999997799999999999999999988753   346777777665444456789999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|++++ .++++.++||+|++|||+
T Consensus       111 ily~~~~-~i~~~~l~dmvv~~CgC~  135 (135)
T 6Q2J_B          111 LIQKTDT-GVSLQTYDDLLAKDCHCI  135 (135)
T ss_pred             EEEECCC-eEEEEEECCeEEeccccC
Confidence            9998874 788899999999999995


No 20
>1KTZ_A TRANSFORMING GROWTH FACTOR BETA 3/TGF-beta; CYTOKINE-RECEPTOR COMPLEX, CYTOKINE-CYTOKINE RECEPTOR COMPLEX; 2.15A {Homo sapiens} SCOP: g.17.1.2
Probab=99.80  E-value=7.5e-25  Score=185.60  Aligned_cols=102  Identities=35%  Similarity=0.837  Sum_probs=76.2  Template_Neff=8.200

Q NP_000548.2     395 NLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSP  473 (501)
Q Consensus       395 ~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~  473 (501)
                      .....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+...   .++|+.++.+++...+...+.|||+|++|++
T Consensus        10 ~~~~~Cc~~~~~V~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~   85 (112)
T 1KTZ_A           10 NLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRSA---DTTHSTVLGLYNTLNPEASASPCCVPQDLEP   85 (112)
T ss_dssp             ---CCCEEECCEEECCCCCCCC-CEEECSEEECCEEECCCCSSCCC---------------------CCCCCEEECCEEE
T ss_pred             cccCCcEEEEEEEECchhcCCC-eeeCCCeeeeeeeeecCCCCCCC---CCChHHHHHHHHhcCcccCCCCcccceecCc
Confidence            3478999999999999 99998 99999999999999999998753   3578877776654444567899999999999


Q NP_000548.2     474 ISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       474 l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ++|||++++ .++++.++||+|++|||+
T Consensus        86 l~ily~~~~-~~~~~~~~~miv~~CgC~  112 (112)
T 1KTZ_A           86 LTILYYVGR-TPKVEQLSNMVVKSCKCS  112 (112)
T ss_dssp             EEEEEEETT-EEEEEEEEEEEECCEEEC
T ss_pred             eEEEEEeCC-eeEEEEecCeEEeeCcCC
Confidence            999999987 577899999999999995


No 21
>5TY4_B TGF-beta receptor type-2 (E.C. 2.7.11.30); TRANSFERASE; 2.9A {Homo sapiens}
Probab=99.80  E-value=9.9e-25  Score=179.89  Aligned_cols=96  Identities=34%  Similarity=0.853  Sum_probs=84.4  Template_Neff=8.500

Q NP_000548.2     400 CSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILF  478 (501)
Q Consensus       400 Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily  478 (501)
                      ||+++++|+|+ ++||+ |||+|++|+++||.|.|..+...   .++|+.++.+++...+.....|||+|++|++++|+|
T Consensus         1 Cc~~~~~v~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~il~   76 (97)
T 5TY4_B            1 CCLRPLYIDFRKDLGWK-WIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIVY   76 (97)
T ss_pred             CeEEEEEEECccccCCC-ceeCCCcccCeeeceeCCCCCCC---CccHHHHHHHHHhcCcccCCCCceeceeccceeEEE
Confidence            89999999997 99998 99999999999999999988653   457888777765444445789999999999999999


Q NP_000548.2     479 IDSANNVVYKQYEDMVVESCGC  500 (501)
Q Consensus       479 ~d~~~~~~~~~~~~mvv~~CgC  500 (501)
                      ++++ +++++.++||+|++|||
T Consensus        77 ~~~~-~~~~~~~~~m~v~~CgC   97 (97)
T 5TY4_B           77 YVGR-KPKVEQLSNMIVKSCKC   97 (97)
T ss_pred             EeCC-ceEEEEecCeEEeeCCC
Confidence            9987 57889999999999999


No 22
>5VT2_B Growth/differentiation factor 15; TGF-beta family, SIGNALING PROTEIN; HET: EDO; 2.3A {Homo sapiens}
Probab=99.80  E-value=1.1e-24  Score=184.58  Aligned_cols=102  Identities=27%  Similarity=0.753  Sum_probs=87.2  Template_Neff=8.300

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....|++++++|+|+||||++|||+|++|+++||.|.|..+...   .++|+.++.+++...+.....|||+|++|++++
T Consensus        11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~   87 (112)
T 5VT2_B           11 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV   87 (112)
T ss_dssp             TTCBSEEEEEEEEHHHHTCTTTEEECSEEEEEEEESBCCTTSSB---CSHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
T ss_pred             CCCcceEEEEEEeHHHhCCCccEECCCeeeceeeeeeCCCCCCc---ccchHHHHHHHHhcCCCCCCCCceecceecceE
Confidence            34455569999999999998899999999999999999998753   457888877765544556789999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|+++ +.+++++++||+|++|||.
T Consensus        88 il~~~~-~~~~~~~~~~m~v~~C~C~  112 (112)
T 5VT2_B           88 LIQKTD-TGVSLQTYDDLLAKDCHCI  112 (112)
T ss_dssp             EEEECS-SSEEEEEEEEEEEEEEEEC
T ss_pred             EEEEcC-CeEEEEEeCCeEEecCCcC
Confidence            999887 4788999999999999995


No 23
>5VZ3_A Growth/differentiation factor 15; Growth Factor, SIGNALING PROTEIN; 1.97A {Homo sapiens}
Probab=99.80  E-value=1.1e-24  Score=184.58  Aligned_cols=102  Identities=27%  Similarity=0.753  Sum_probs=87.2  Template_Neff=8.300

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....|++++++|+|+||||++|||+|++|+++||.|.|..+...   .++|+.++.+++...+.....|||+|++|++++
T Consensus        11 ~~~~C~~~~~~V~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~i~~~~~~~~~~~~~~~CC~P~~~~~l~   87 (112)
T 5VZ3_A           11 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRA---ANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMV   87 (112)
T ss_dssp             SSSBSEEEEEEEEHHHHTCTTTEEECSEEEEEEEESBCCTTSSB---CSHHHHHHHHHHHHCTTTSCCCCEEEEEEEEEE
T ss_pred             CCCcceEEEEEEeHHHhCCCccEECCCeeeceeeeeeCCCCCCc---ccchHHHHHHHHhcCCCCCCCCceecceecceE
Confidence            34455569999999999998899999999999999999998753   457888877765544556789999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|+++ +.+++++++||+|++|||.
T Consensus        88 il~~~~-~~~~~~~~~~m~v~~C~C~  112 (112)
T 5VZ3_A           88 LIQKTD-TGVSLQTYDDLLAKDCHCI  112 (112)
T ss_dssp             EEEECS-SSEEEEEEEEEEEEEEEEC
T ss_pred             EEEEcC-CeEEEEEeCCeEEecCCcC
Confidence            999887 4788999999999999995


No 24
>2ARP_A Inhibin beta A chain, Follistatin; cystine knot, disulfide rich, egf; HET: GOL, 1PG; 2.0A {Homo sapiens} SCOP: g.17.1.2
Probab=99.79  E-value=1.3e-24  Score=184.92  Aligned_cols=105  Identities=38%  Similarity=0.831  Sum_probs=81.5  Template_Neff=8.700

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS  472 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~  472 (501)
                      ...||++.++|+|++|||++|||+|++|+++||.|.|..+.....  ..++|+.++.++..  ..+.....|||+|++|+
T Consensus         8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~   87 (116)
T 2ARP_A            8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR   87 (116)
T ss_dssp             -CCSEEECCEEEHHHHTCTTTEEECSEEECCEEESCCCC-CCHHH----H----HHHHTTSTTCSSCCCCCCCEEEEEEE
T ss_pred             cccceeEEEEEeHHHcCCccceeCCCceeCceeeeeCCCCcCcCCCCCcchHHHHHHHHHhhCCCCCcCCCCcccccccC
Confidence            678999999999999999889999999999999999998865321  12456655554321  12335679999999999


Q NP_000548.2     473 PISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +++|+|++++++++++.++||+|++|||+
T Consensus        88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~  116 (116)
T 2ARP_A           88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS  116 (116)
T ss_dssp             EEEEEEEC-TTCEEEEEEEEEEEEEEEEC
T ss_pred             ceEEEEEcCCCcEEEEEeCCeEEeecccC
Confidence            99999999877788999999999999995


No 25
>2ARV_A Inhibin beta A chain; homodimer, cystine knot, disulfide linked; HET: 1PG, SO4, GOL; 2.0A {Homo sapiens} SCOP: g.17.1.2
Probab=99.79  E-value=1.3e-24  Score=184.92  Aligned_cols=105  Identities=38%  Similarity=0.831  Sum_probs=86.7  Template_Neff=8.700

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS  472 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~  472 (501)
                      ...||++.++|+|++|||++|||+|++|+++||.|.|+.+.....  +.++|+.++.++..  ..+.....|||+|++|+
T Consensus         8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~   87 (116)
T 2ARV_A            8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR   87 (116)
T ss_dssp             CCBSEEECCEEETTTTTCTTTEEECSEEECCEEESBCCGGGTTEETTEECHHHHHHHHHHHTTCTTTTTSCCCEEEEEEE
T ss_pred             cccceeEEEEEeHHHcCCccceeCCCeEeCeeeEEECCCCCCCCCCCCcchHHHHHHHHHhcCCCCccCCCCccccceec
Confidence            678999999999999999889999999999999999998865321  12456655554321  12335679999999999


Q NP_000548.2     473 PISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +++|||++++++++++.++||+|++|||+
T Consensus        88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~  116 (116)
T 2ARV_A           88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS  116 (116)
T ss_dssp             EEEEEEEETTTEEEEEEEEEEEEEEEEEC
T ss_pred             cEEEEEEeCCCeEEEEEeCCeEEeeccCC
Confidence            99999999877788999999999999995


No 26
>2P6A_B Activin A, Follistatin 315; Follistatin, Activin,Inhibin, TGF-beta, SIGNALING PROTEIN; 3.4A {Homo sapiens} SCOP: g.17.1.2
Probab=99.79  E-value=1.3e-24  Score=184.92  Aligned_cols=105  Identities=38%  Similarity=0.831  Sum_probs=86.7  Template_Neff=8.700

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHL--EPTNHAVIQTLMNS--MDPESTPPTCCVPTRLS  472 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~--~~~~h~~i~~~~~~--~~~~~~~~pCC~P~~~~  472 (501)
                      ...||++.++|+|++|||++|||+|++|+++||.|.|+.+.....  +.++|+.++.++..  ..+.....|||+|++|+
T Consensus         8 ~~~C~~~~~~v~f~~lgw~~~Ii~P~~~~~~~C~G~C~~~~~~~~~~~~~~h~~~~~~~~~~~~~~~~~~~~CC~P~~~~   87 (116)
T 2P6A_B            8 VNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR   87 (116)
T ss_pred             cccceeEEEEEeHHHcCCccceeCCCeEeCeeeEEECCCCCCCCCCCCcchHHHHHHHHHhcCCCCccCCCCccccceec
Confidence            678999999999999999889999999999999999998865321  12456655554321  12335679999999999


Q NP_000548.2     473 PISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +++|||++++++++++.++||+|++|||+
T Consensus        88 ~l~il~~~~~~~~~~~~~~~m~v~~CgC~  116 (116)
T 2P6A_B           88 PMSMLYYDDGQNIIKKDIQNMIVEECGCS  116 (116)
T ss_pred             cEEEEEEeCCCeEEEEEeCCeEEeeccCC
Confidence            99999999877788999999999999995


No 27
>2TGI_A TRANSFORMING GROWTH FACTOR-BETA TWO (TGF-B2); GROWTH FACTOR; 1.8A {Homo sapiens} SCOP: g.17.1.2
Probab=99.79  E-value=1.5e-24  Score=183.69  Aligned_cols=101  Identities=35%  Similarity=0.828  Sum_probs=88.1  Template_Neff=8.200

Q NP_000548.2     396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI  474 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l  474 (501)
                      ....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+...   .++|+.++.+++...+.....|||+|++|+++
T Consensus        11 ~~~~Cc~~~~~V~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~h~~~~~~~~~~~~~~~~~~CC~P~~~~~l   86 (112)
T 2TGI_A           11 VQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPL   86 (112)
T ss_dssp             CCSBSEEECCEEECCCCCCCT-TEEECSEEECCEEECBCCTTSSB---CSHHHHHHHHHHHHCGGGCCCCCEEECSEEEE
T ss_pred             CCCCcEEEEEEEECchhhCCc-eeeCCCeEeceeecccCCCCCCC---cccHHHHHHHHHhcCcccCCCCceeceeecce
Confidence            478999999999999 99998 99999999999999999988653   34677777766544444678999999999999


Q NP_000548.2     475 SILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       475 ~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +|||++++ +++++.++||+|++|||+
T Consensus        87 ~il~~~~~-~~~~~~~~~m~v~~CgC~  112 (112)
T 2TGI_A           87 TILYYIGK-TPKIEQLSNMIVKSCKCS  112 (112)
T ss_dssp             EEEEEETT-EEEEEEEEEEEECCEEEC
T ss_pred             EEEEEeCC-ceEEEEeCCeEEEeCCCC
Confidence            99999986 578899999999999995


No 28
>3HH2_B Growth/differentiation factor 8, Follistatin; protein-protein complex, TB domain, cystine; HET: PO4, CIT; 2.15A {Mus musculus}
Probab=99.79  E-value=2.4e-24  Score=181.50  Aligned_cols=99  Identities=39%  Similarity=0.949  Sum_probs=82.7  Template_Neff=8.200

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|++|||+ |||+|++|+++||.|.|..+....   .+|+.   +++...+.....|||+|++|++++
T Consensus        11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~---l~~~~~~~~~~~~CC~P~~~~~l~   83 (109)
T 3HH2_B           11 TESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQK---YPHTH---LVHQANPRGSAGPCCTPTKMSPIN   83 (109)
T ss_dssp             CCCBSEEECCEEEHHHHTCT-TEEECSEEECCEEECBCCTTTTBC---CHHHH---HHHHHCCTTCCCCCEEEEEEEEEE
T ss_pred             CCCceeeeEEEEehHHhCCc-eEECCCeeeceEeceeCCCccccc---CCcce---ehhhcCCCCCCCCCccceeeCCeE
Confidence            46799999999999999998 999999999999999999987542   13332   222222235689999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|++++++++++.++||+|++|||+
T Consensus        84 il~~~~~~~~~~~~~~~m~v~~CgC~  109 (109)
T 3HH2_B           84 MLYFNGKEQIIYGKIPAMVVDRCGCS  109 (109)
T ss_dssp             EEEECTTCCEEEEEEEEEEEEEEEEC
T ss_pred             EEEEcCCCeEEEEEeCCeEEecccCC
Confidence            99999877788999999999999995


No 29
>5F3B_C RK35 Chimeric antibody heavy chain; myostatin, antibody, complex, Signaling Protein-Immune; HET: GOL; 1.76A {Mus musculus}
Probab=99.79  E-value=2.4e-24  Score=181.50  Aligned_cols=99  Identities=39%  Similarity=0.949  Sum_probs=82.7  Template_Neff=8.200

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|++|||+ |||+|++|+++||.|.|..+....   .+|+.   +++...+.....|||+|++|++++
T Consensus        11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~---l~~~~~~~~~~~~CC~P~~~~~l~   83 (109)
T 5F3B_C           11 TESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQK---YPHTH---LVHQANPRGSAGPCCTPTKMSPIN   83 (109)
T ss_pred             CCCceeeeEEEEehHHhCCc-eEECCCeeeceEeceeCCCccccc---CCcce---ehhhcCCCCCCCCCccceeeCCeE
Confidence            46799999999999999998 999999999999999999987542   13332   222222235689999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|++++++++++.++||+|++|||+
T Consensus        84 il~~~~~~~~~~~~~~~m~v~~CgC~  109 (109)
T 5F3B_C           84 MLYFNGKEQIIYGKIPAMVVDRCGCS  109 (109)
T ss_pred             EEEEcCCCeEEEEEeCCeEEecccCC
Confidence            99999877788999999999999995


No 30
>3KFD_D Transforming growth factor beta-1, TGF-beta; TGF-beta, TGF-b1, TGF-beta receptor type-1; 2.995A {Homo sapiens}
Probab=99.78  E-value=3.7e-24  Score=181.25  Aligned_cols=102  Identities=30%  Similarity=0.731  Sum_probs=87.9  Template_Neff=8.300

Q NP_000548.2     395 NLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSP  473 (501)
Q Consensus       395 ~~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~  473 (501)
                      .....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+...   .++|+.++.+++...+..+..|||+|++|++
T Consensus        10 ~~~~~C~~~~~~v~f~~~lg~~-~Ii~P~~~~~~~C~G~C~~~~~~---~~~~~~~~~~~~~~~~~~~~~~CC~P~~~~~   85 (112)
T 3KFD_D           10 STEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWSL---DTQYSKVLALYNQHNPGASAAPCCVPQALEP   85 (112)
T ss_pred             CCCCCcEEEEEEEECccccCCc-eeeCCCeEEeeeeceeCCCCCCC---cccHHHHHHHHHhhCCCCCCCCccccccccc
Confidence            3477899999999998 99998 99999999999999999988653   3467777766654444467899999999999


Q NP_000548.2     474 ISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       474 l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ++|+|++++ +++++.++||+|++|||+
T Consensus        86 l~ily~~~~-~~~~~~~~~m~v~~CgC~  112 (112)
T 3KFD_D           86 LPIVYYVGR-KPKVEQLSNMIVRSCKCS  112 (112)
T ss_pred             eeEEEEeCC-eEEEEEeCCeEEEecCCC
Confidence            999999987 577899999999999995


No 31
>5E4G_A Growth/differentiation factor 11; Bone morphogenetic protein 11, BMP-11; HET: PG4; 1.5A {Homo sapiens}
Probab=99.76  E-value=1.2e-23  Score=177.01  Aligned_cols=99  Identities=37%  Similarity=0.939  Sum_probs=83.0  Template_Neff=8.400

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPIS  475 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~  475 (501)
                      ....||+++++|+|+||||+ |||+|++|+++||.|+|..+....   .+|+.+   +....+..++.|||+|++|++++
T Consensus        11 ~~~~C~~~~~~V~f~~lgw~-~Ii~P~~~~~~~C~G~C~~~~~~~---~~~~~l---~~~~~~~~~~~~cC~P~~~~~l~   83 (109)
T 5E4G_A           11 SESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQK---YPHTHL---VQQANPRGSAGPCCTPTKMSPIN   83 (109)
T ss_dssp             CCCBSEEECCEEETTTTTCT-TEEECSEEECCEEECBCCTTTTCS---STHHHH---HHHHCCTTCCCCCEEEEEEEEEE
T ss_pred             CcCceEeEEEEEehHHcCCc-eEeCCCeeeceeecccCCcccccc---CCchHH---HHhcCCCCCCCCCccceeeccEE
Confidence            47799999999999999998 999999999999999999987532   133322   11122345789999999999999


Q NP_000548.2     476 ILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       476 ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+|++++++++++.++||+|++|||+
T Consensus        84 il~~~~~~~~~~~~~~d~~v~~C~C~  109 (109)
T 5E4G_A           84 MLYFNDKQQIIYGKIPGMVVDRCGCS  109 (109)
T ss_dssp             EEEECSSSCEEEEEEEEEEEEEEEEC
T ss_pred             EEEEcCCCeEEEEEeCCeEEeeccCC
Confidence            99999887888999999999999995


No 32
>5NMZ_B Neurturin; cystine knot, neurotrophic factor, GFL; HET: GOL; 1.6A {Homo sapiens}
Probab=99.71  E-value=2.2e-22  Score=166.98  Aligned_cols=93  Identities=22%  Similarity=0.465  Sum_probs=76.9  Template_Neff=8.300

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRLS  472 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~~  472 (501)
                      ...||+++++|+|+||||+ | |+|++|+++||.|.|..+..      +| +.++.+++...   +.....|||+|++|+
T Consensus         4 ~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~CC~P~~~~   75 (101)
T 5NMZ_B            4 ARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAYE   75 (101)
T ss_dssp             CCBSEEEEEEEEGGGGTSS-C-CCCCEEEEEEEECBCGGGCC------HHHHHHHHHHTTTCSTTCCBCCSCCEEEEEEC
T ss_pred             CCCccceEEEEeHHHcCCe-e-ecCCeEECeeeceeCCchhh------chHHHHHHHHHhhhhhccccCCCCceeeeeec
Confidence            5689999999999999999 8 89999999999999999864      23 33444433322   246789999999999


Q NP_000548.2     473 -PISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       473 -~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                       +++  |+|++  ++++.++||+|++|||+
T Consensus        76 ~~l~--y~d~~--~~~~~~~~m~v~~CgC~  101 (101)
T 5NMZ_B           76 DEVS--FLDAH--SRYHTVHELSARECACV  101 (101)
T ss_dssp             SEEE--EECTT--CCEEEEESCSEEEEEEC
T ss_pred             CceE--eecCC--cEEEEeCCeeeecccCC
Confidence             999  77764  78899999999999995


No 33
>5NMZ_C Neurturin; cystine knot, neurotrophic factor, GFL; HET: GOL; 1.6A {Homo sapiens}
Probab=99.71  E-value=2.2e-22  Score=166.98  Aligned_cols=93  Identities=22%  Similarity=0.465  Sum_probs=76.9  Template_Neff=8.300

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRLS  472 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~~  472 (501)
                      ...||+++++|+|+||||+ | |+|++|+++||.|.|..+..      +| +.++.+++...   +.....|||+|++|+
T Consensus         4 ~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~CC~P~~~~   75 (101)
T 5NMZ_C            4 ARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAYE   75 (101)
T ss_dssp             CCBSEEEEEEEEGGGGTSS-S-CCCCEEEEEEEECBCCTTSC------HHHHHHHHHHHTTCSTTCCCCCSCCEEEEEEC
T ss_pred             CCCccceEEEEeHHHcCCe-e-ecCCeEECeeeceeCCchhh------chHHHHHHHHHhhhhhccccCCCCceeeeeec
Confidence            5689999999999999999 8 89999999999999999864      23 33444433322   246789999999999


Q NP_000548.2     473 -PISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       473 -~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                       +++  |+|++  ++++.++||+|++|||+
T Consensus        76 ~~l~--y~d~~--~~~~~~~~m~v~~CgC~  101 (101)
T 5NMZ_C           76 DEVS--FLDAH--SRYHTVHELSARECACV  101 (101)
T ss_dssp             SCEE--EECTT--SCEEEESSCSEEEEEEC
T ss_pred             CceE--eecCC--cEEEEeCCeeeecccCC
Confidence             999  77764  78899999999999995


No 34
>2GH0_C artemin, GDNF family receptor alpha-3; cystine-knot, helix bundle, HORMONE-GROWTH FACTOR; HET: BMA, NAG, MAN; 1.92A {Homo sapiens}
Probab=99.71  E-value=2.9e-22  Score=166.00  Aligned_cols=95  Identities=19%  Similarity=0.418  Sum_probs=77.9  Template_Neff=8.600

Q NP_000548.2     398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD----PESTPPTCCVPTRLSP  473 (501)
Q Consensus       398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~----~~~~~~pCC~P~~~~~  473 (501)
                      ..||+++++|+|+||||++|||  ++|+++||.|.|+.+....  .+.|+.++.++ ...    ....+.|||+|++|++
T Consensus         2 ~~C~~~~~~V~f~dlgw~~~I~--~~~~~~~C~G~C~~~~~~~--~~~~~~l~~~~-~~~~~~~~~~~~~~CC~P~~~~~   76 (101)
T 2GH0_C            2 PGCRLRSQLVPVRALGLGHRSD--ELVRFRFCSGSCRRARSPH--DLSLASLLGAG-ALRPPPGSRPVSQPCCRPTRYEA   76 (101)
T ss_pred             CCCcceEEEEeHHHcCCCcccC--cEEecceeeeeCCCCCCCc--cchHHHHHHcc-cCCCCCCCCCCCCCceeeeeecc
Confidence            4799999999999999988988  9999999999999987642  23455554443 111    1357899999999999


Q NP_000548.2     474 ISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       474 l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ++|||+++    +++.++||+|++|||+
T Consensus        77 l~il~~~~----~~~~~~~m~v~~CgC~  100 (101)
T 2GH0_C           77 VSFMDVNS----TWRTVDRLSATACGCL  100 (101)
T ss_pred             eEEEEeCC----eeEEEcceEeeccccc
Confidence            99999875    5789999999999995


No 35
>5MR4_B Neurturin, GDNF family receptor alpha-2; Complex, Signalling, Receptor, signaling protein; 2.4A {Homo sapiens}
Probab=99.70  E-value=4.4e-22  Score=165.39  Aligned_cols=94  Identities=21%  Similarity=0.445  Sum_probs=76.5  Template_Neff=8.200

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD---PESTPPTCCVPTRL  471 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~---~~~~~~pCC~P~~~  471 (501)
                      ....||+++++|+|+||||+ | |+|++|+++||.|.|+.+..      +| +.++.++....   +.....|||+|++|
T Consensus         4 ~~~~C~~~~~~v~f~dlgw~-~-i~P~~~~~~~C~G~C~~~~~------~~~~~~~~~~~~~~~~~~~~~~~~CC~P~~~   75 (102)
T 5MR4_B            4 GARPCGLRELEVRVSELGLG-Y-ASDETVLFRYCAGACEAAAR------VYDLGLRRLRQRRRLRRERVRAQPCCRPTAY   75 (102)
T ss_dssp             -CCBSEEEEEEEEGGGGSSS-C-CCCCEEEEEEEESBCCSCCC------HHHHHHHHHHHTTCSTTCCCCCSCCEEEEEE
T ss_pred             CCCCceeeEEEEEHHHcCCc-e-eCCCeEECeeeceeCCchhc------chHHHHHHHHHhhhhhccccCCCCceeeeee
Confidence            35789999999999999998 7 89999999999999999864      23 33333333222   24678999999999


Q NP_000548.2     472 S-PISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       472 ~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      + +++  |+|++  ++++.++||+|++|||+
T Consensus        76 ~~~l~--y~d~~--~~~~~~~~m~v~~CgC~  102 (102)
T 5MR4_B           76 EDEVS--FLDAH--SRYHTVHELSARECACV  102 (102)
T ss_dssp             CCEEE--EECTT--SCEEEEESCSEEEEEEC
T ss_pred             cCceE--eecCC--cEEEEECCeeeccccCC
Confidence            9 999  77764  78999999999999995


No 36
>2V5E_B GDNF FAMILY RECEPTOR ALPHA-1, GLIAL; RECEPTOR-GLYCOPROTEIN COMPLEX, CELL MEMBRANE, GROWTH; HET: NAG, EDO, SCR; 2.35A {RATTUS NORVEGICUS}
Probab=99.69  E-value=7.4e-22  Score=163.65  Aligned_cols=93  Identities=24%  Similarity=0.547  Sum_probs=77.2  Template_Neff=8.400

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD--PESTPPTCCVPTRLS-  472 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~--~~~~~~pCC~P~~~~-  472 (501)
                      ...||+++++|+|+||||+ | |+|++|+++||.|.|+.+..      +| +.++.+++...  +..+..|||+|++|+ 
T Consensus         5 ~~~C~~~~~~V~f~~lgw~-~-i~P~~~~~~~C~G~C~~~~~------~h~~~~~~l~~~~~~~~~~~~~~CC~P~~~~~   76 (101)
T 2V5E_B            5 NRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCDAAET------TYDKILKNLSRNRRLVSDKVGQACCRPIAFDD   76 (101)
T ss_dssp             TTTCEEEEEEEEGGGGCSS-C-CCSCEEEEEEEESCCCSCCS------HHHHHHHHHHHTTSSSSSSTTCCCEEEEEECC
T ss_pred             CCcceeeEEEEEHHHcCCc-c-cCCCeEECceecEeCCCCCC------cHHHHHHHHHhccCCCcccCCCCeEEeeEecC
Confidence            5689999999999999998 7 89999999999999999842      45 44554443321  345789999999999 


Q NP_000548.2     473 PISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       473 ~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +++  |+|++  ++++.++||+|++|||+
T Consensus        77 ~l~--y~d~~--~~~~~~~~m~v~~CgC~  101 (101)
T 2V5E_B           77 DLS--FLDDN--LVYHILRKHSAKRCGCI  101 (101)
T ss_dssp             CEE--EECTT--SCEEEECSCSEEEEEEC
T ss_pred             ceE--EecCC--EEEEEecCcEecccccC
Confidence            999  77775  57899999999999995


No 37
>2ASK_B artemin; Glial cell derived family ligand; HET: SO4; 1.55A {Homo sapiens}
Probab=99.69  E-value=9.1e-22  Score=166.60  Aligned_cols=94  Identities=20%  Similarity=0.467  Sum_probs=77.2  Template_Neff=8.000

Q NP_000548.2     396 LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVP  468 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P  468 (501)
                      ....||+++++|+|+||||+ | |+|++|+++||.|.|..+.      ++| +.++.+++...      ......|||+|
T Consensus        12 ~~~~Cc~~~~~V~F~dlgw~-~-i~P~~~~~~~C~G~C~~~~------~~h~~~~~~l~~~~~~~~~~~~~~~~~~CC~P   83 (113)
T 2ASK_B           12 GARGCRLRSQLVPVRALGLG-H-RSDELVRFRFCSGSCRRAR------SPHDLSLASLLGAGALRPPPGSRPVSQPCCRP   83 (113)
T ss_dssp             -CCBSEEEEEEEEGGGGSSS-C-CBSSEEEEEEEECBCGGGC------CHHHHHHHHHHHTTCSCCCSSSCCCCSCEEEE
T ss_pred             CCCCceeEEEEEEHHHcCCC-c-cCCCeEECceEeeeCCCCC------CCcHHHHHHHHHccCCCCCCCCCCCCCCceee
Confidence            46799999999999999998 6 7999999999999999983      245 45555554332      23578999999


Q NP_000548.2     469 TRLSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       469 ~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ++|++++  |+|++  +++++++||+|++|||.
T Consensus        84 ~~~~~l~--y~d~~--~~~~~l~~miv~~CgC~  112 (113)
T 2ASK_B           84 TRYEAVS--FMDVN--STWRTVDRLSATACGCL  112 (113)
T ss_dssp             EEEEEEE--EEBTT--SCEEEEEEEEEEEEEEE
T ss_pred             eEeceee--eecCC--cEEEEECCeEEeccccc
Confidence            9999877  77775  67899999999999995


No 38
>3FUB_D GDNF family receptor alpha-1, Glial; GFRALPHA1, ALL ALPHA GDNF, CYSTINE; HET: NAG, EDO; 2.35A {Rattus norvegicus}
Probab=99.69  E-value=9.6e-22  Score=171.18  Aligned_cols=96  Identities=24%  Similarity=0.517  Sum_probs=80.0  Template_Neff=6.800

Q NP_000548.2     394 KNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSM--DPESTPPTCCVPTR  470 (501)
Q Consensus       394 ~~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~--~~~~~~~pCC~P~~  470 (501)
                      ......||++.++|+|+||||+ | |+|++|+++||.|.|.++.      ++| ++++.+++..  .+..+..|||+|++
T Consensus        35 ~~~~~~Ccr~~l~V~F~dlGw~-~-iaP~~f~~~~C~G~C~~~~------t~h~~~l~~l~~~~~~~~~~~~~pCCvP~~  106 (134)
T 3FUB_D           35 RGKNRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCDAAE------TTYDKILKNLSRNRRLVSDKVGQACCRPIA  106 (134)
T ss_pred             CCCCCcceEEEEEEeHHHcCCC-c-cCCCeEEeEEeeCCCCCCc------chHHHHHHHHHHcCCCCCCCCCCCeeeeeE
Confidence            3457899999999999999998 6 5999999999999999982      356 5666665543  12357899999999


Q NP_000548.2     471 LS-PISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       471 ~~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      |+ +++  |++++ + ++++++||+|++|||.
T Consensus       107 ~~~~l~--y~d~~-~-~~~~l~~mvv~~CgC~  134 (134)
T 3FUB_D          107 FDDDLS--FLDDN-L-VYHILRKHSAKRCGCI  134 (134)
T ss_pred             eCCcee--EECCC-c-eEEEEcCeEEecccCC
Confidence            99 988  77776 4 7899999999999995


No 39
>1AGQ_C GLIAL CELL-DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR, NEUROTROPHIC FACTOR, CYSTINE; 1.9A {Rattus norvegicus} SCOP: g.17.1.2
Probab=99.67  E-value=2.2e-21  Score=169.01  Aligned_cols=95  Identities=26%  Similarity=0.544  Sum_probs=76.0  Template_Neff=6.700

Q NP_000548.2     395 NLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD--PESTPPTCCVPTRL  471 (501)
Q Consensus       395 ~~~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~--~~~~~~pCC~P~~~  471 (501)
                      .....||++.++|+|+||||+ | |+|.+|+++||.|.|.++.      ++| ++++.+++...  +..+..|||+|++|
T Consensus        37 ~~~~~Cc~~~l~V~F~dlGW~-i-iaP~~~~~~~C~G~C~~~~------t~h~~~l~~l~~~~~~~~~~~~~pCCvP~~~  108 (135)
T 1AGQ_C           37 GKNRGCVLTAIHLNVTDLGLG-Y-ETKEELIFRYCSGSCEAAE------TMYDKILKNLSRSRRLTSDKVGQACCRPVAF  108 (135)
T ss_dssp             ----CCEEEEEEEEGGGGCSC-C-CCCCEEEEEEEESCCCCCC------SHHHHHHHHHHHTTCC----CCCCCEEEEEE
T ss_pred             CCCCCceEEEEEEEHHHcCCC-c-cCCCeEEeEEecCCCCCCc------chHHHHHHHHHhhcCCCCcccCCCeeeeeee
Confidence            457899999999999999998 5 8999999999999999972      367 66666655432  33578999999999


Q NP_000548.2     472 S-PISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       472 ~-~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      + +++  |++++  +++++++||+|++|||.
T Consensus       109 ~~~l~--y~d~~--~~~~~l~dmiv~~CgC~  135 (135)
T 1AGQ_C          109 DDDLS--FLDDS--LVYHILRKHSAKRCGCI  135 (135)
T ss_dssp             CCCEE--EECSS--SCEEEECSCSEEEEEEC
T ss_pred             cCCee--eecCC--eEEEEEcCeEEecccCC
Confidence            9 999  77765  47899999999999995


No 40
>5TX2_A Transforming growth factor beta-2; Growth factor, CYTOKINE; 1.82A {Mus musculus}
Probab=99.66  E-value=2.9e-21  Score=157.69  Aligned_cols=81  Identities=33%  Similarity=0.827  Sum_probs=74.0  Template_Neff=7.400

Q NP_000548.2     396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI  474 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l  474 (501)
                      ....||+++++|+|+ ||||+ |||+|++|+++||.|.|..+.                       .+.+||+|++|+++
T Consensus        12 ~~~~C~~~~~~v~f~~dlgw~-~Ii~P~~~~~~~C~G~C~~~~-----------------------~~~~CC~P~~~~~l   67 (93)
T 5TX2_A           12 VQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYRA-----------------------SKSPSCVSQDLEPL   67 (93)
T ss_dssp             CCSBSEEECCEEEHHHHHCCC-SEEECSEEECCEEECBCCCCS-----------------------SSCCCEEECCEEEE
T ss_pred             CCCCcEEEEEEEECchhcCCC-cEeCCCeEEcEEecccCCCCC-----------------------CCCCCceeceecce
Confidence            478999999999999 99998 999999999999999998751                       25799999999999


Q NP_000548.2     475 SILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       475 ~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +|||++++ +++++.++||+|++|||+
T Consensus        68 ~il~~~~~-~~~~~~l~~~~v~~CgC~   93 (93)
T 5TX2_A           68 TILYYIGN-TPKIEQLSNMIVKSCKCS   93 (93)
T ss_dssp             EEEEEETT-EEEEEEEEEEEECEEEEC
T ss_pred             EEEEEeCC-eEEEEEEcCcEEecCccC
Confidence            99999986 578999999999999995


No 41
>5TX4_B TGF-beta receptor type-2 (E.C.2.7.11.30), Transforming; TGF-beta, TGF-beta type II receptor; 1.876A {Homo sapiens}
Probab=99.66  E-value=3e-21  Score=157.29  Aligned_cols=81  Identities=31%  Similarity=0.818  Sum_probs=74.3  Template_Neff=7.500

Q NP_000548.2     396 LKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPI  474 (501)
Q Consensus       396 ~~~~Cc~~~l~V~F~-dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l  474 (501)
                      ....||+++++|+|+ +|||+ |||+|++|+++||.|.|..+.                       .+.|||+|++|+++
T Consensus        11 ~~~~C~~~~~~v~f~~~lgw~-~Ii~P~~~~~~~C~G~C~~~~-----------------------~~~~CC~P~~~~~~   66 (92)
T 5TX4_B           11 VQDNCCLRPLYIDFRKDLGWK-WIHEPKGYNANFCAGACPYRA-----------------------SKSPSCVSQDLEPL   66 (92)
T ss_pred             CCCCcEEEEEEEECchhcCCC-ceeCCCeEEcEEeeccCCCCC-----------------------CCCCceeccccCce
Confidence            467999999999998 99998 999999999999999998752                       25799999999999


Q NP_000548.2     475 SILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       475 ~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +|||++++ +++++.++||+|++|+|+
T Consensus        67 ~il~~~~~-~i~~~~~~~~~v~~C~C~   92 (92)
T 5TX4_B           67 TIVYYVGR-KPKVEQLSNMIVKSCKCS   92 (92)
T ss_pred             eEEEEeCC-eeEEEEEcCeEEecCCCC
Confidence            99999987 678999999999999995


No 42
>2GYZ_A neurotrophic factor artemin isoform 3; neurotrophic factor, cystine-knot, HORMONE-GROWTH FACTOR; 1.76A {Homo sapiens}
Probab=99.57  E-value=1.4e-19  Score=150.88  Aligned_cols=89  Identities=18%  Similarity=0.342  Sum_probs=71.6  Template_Neff=7.300

Q NP_000548.2     399 RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVPTRL  471 (501)
Q Consensus       399 ~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P~~~  471 (501)
                      .||+++++|+|+||||+  ||+|++|+++||.|+|..+..      ++ +.++.++....      +.....|||+|++|
T Consensus         1 ~Cc~~~l~V~F~dlGw~--IiaP~~~~a~yC~G~C~~~~~------~~~~~~~~l~~~~~~~~~~~~~~~~~pCC~P~~~   72 (105)
T 2GYZ_A            1 GCRLRSQLVPVRALGLG--HRSDELVRFRFCSGSCRRARS------PHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRY   72 (105)
T ss_dssp             CCEEEEEEEEGGGGSSS--CCCSSEEEEEEEESCCGGGCC------HHHHHHHHHHHTTCSCCCSSSCCCSSCCCEEEEE
T ss_pred             CCeeEEEEEeHHHcCCc--cccCCceeceEEeccCCCCCC------chHHHHHHHHHhcCCCCCCCCCCCCCCeeeeeee
Confidence            49999999999999998  899999999999999999853      22 23323332221      24578999999999


Q NP_000548.2     472 SPISILFIDSA-NNVVYKQYEDMVVES  497 (501)
Q Consensus       472 ~~l~ily~d~~-~~~~~~~~~~mvv~~  497 (501)
                      ++++  |+|++ +.+++++++||+|..
T Consensus        73 ~~l~--y~d~~~~~i~~~~lp~m~~~~   97 (105)
T 2GYZ_A           73 EAVS--FMDVNSTWRTVDRLSATACGC   97 (105)
T ss_dssp             EEEE--EECTTSCEEEEEEEEEEEEEC
T ss_pred             ceee--EEeCCCCeEEEEEeccceeec
Confidence            9999  88876 578899999999875


No 43
>6Q2S_B Ubiquitin-like protein SMT3,Artemin, GDNF family; RET, receptor tyrosine kinase, cryo-EM; HET: NAG; 3.8A {Saccharomyces cerevisiae}
Probab=99.47  E-value=2.9e-18  Score=163.18  Aligned_cols=93  Identities=20%  Similarity=0.483  Sum_probs=77.2  Template_Neff=8.400

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNH-AVIQTLMNSMD------PESTPPTCCVPT  469 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h-~~i~~~~~~~~------~~~~~~pCC~P~  469 (501)
                      ...||++.++|+|++|||+  ||+|.+|+++||.|.|..+.      ++| +.++.+++...      ......|||+|+
T Consensus       135 ~~~C~~~~~~V~f~~lgw~--ii~P~~~~~~~C~G~C~~~~------~~~~~~~~~l~~~~~~~~~~~~~~~~~~CC~P~  206 (235)
T 6Q2S_B          135 ARGCRLRSQLVPVRALGLG--HRSDELVRFRFCSGSCRRAR------SPHDLSLASLLGAGALRPPPGSRPVSQPCCRPT  206 (235)
T ss_pred             CceeeeecCccchHHcCCe--eecCCeEECccccCCCCCCC------CCHHHHHHHHHHcCCCCCCCCCCCCCCCccCce
Confidence            5789999999999999998  58999999999999999983      255 45555554332      135789999999


Q NP_000548.2     470 RLSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       470 ~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      +|++++  |++++  +++++++||+|++|||+
T Consensus       207 ~~~~l~--y~~~~--~~~~~~~~m~v~~CgC~  234 (235)
T 6Q2S_B          207 RYEAVS--FMDVN--STWRTVDRLSATACGCL  234 (235)
T ss_pred             ecCeee--eecCC--eEEEEeCCcEEeccccc
Confidence            999988  77764  67899999999999995


No 44
>6GFF_E Transforming growth factor beta-1, Leucine-rich; GARP, TGF-B1, Activation, Treg, IMMUNE; HET: BMA, MAN, NAG; 3.1A {Mus musculus}
Probab=98.95  E-value=1.1e-13  Score=131.10  Aligned_cols=158  Identities=22%  Similarity=0.234  Sum_probs=101.3  Template_Neff=9.700

Q NP_000548.2     143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGN------SSVKLEAGLANTITSFIDKGQDDRG-P  215 (501)
Q Consensus       143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~------~~~~~~~~~~n~Vrsf~~~~~~~~~-~  215 (501)
                      .+||++|||+++|+++..    .+.+++++|++||+.+.........      ..+.+....+++|++|......... .
T Consensus        22 ~~IL~~Lgl~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~   97 (249)
T 6GFF_E           22 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ   97 (249)
T ss_pred             HHHHHHcCCCCCCCCCCC----CCCCccHHHHHHHHhhhccccCCCCCcccCCcccchhcccceeeeecCCCCCCCcccC
Confidence            689999999999998651    1245689999999987665321100      0111223456788888654332100 1


Q NP_000548.2     216 VVRKQRYVFDISALE----K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG  290 (501)
Q Consensus       216 ~~~~~~l~FnlSsi~----~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g  290 (501)
                      ......+.|++++++    . +.|.+|+||||+.....           ...|.||...... ...++..+.+.....++
T Consensus        98 ~~~~~~l~F~ls~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~~-~~~~l~~~~v~~~~~~~  165 (249)
T 6GFF_E           98 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSNN-SWRYLSNRLLAPSDSPE  165 (249)
T ss_pred             CCCcEEEEEecccCCCCCCCccceEEEEEEEEeCCCCC-----------cEEEEEEEecCCC-ceeEEEEEEeecCCCCc
Confidence            234677999999742    2 47999999999987642           3566777643210 11123333221234579


Q NP_000548.2     291 WEVFDIWKLFRNFKNSA--QLCLELEAW  316 (501)
Q Consensus       291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~  316 (501)
                      |+.||||.+|+.|+.++  +++|.|.+.
T Consensus       166 W~~~dvt~~v~~W~~~~~~n~gl~v~v~  193 (249)
T 6GFF_E          166 WLSFDVTGVVRQWLSRGGEIEGFRLSAH  193 (249)
T ss_pred             eEEEEcHHHHHHHHhCCcccceEEEEEE
Confidence            99999999999999986  788886554


No 45
>6GFF_G Transforming growth factor beta-1, Leucine-rich; GARP, TGF-B1, Activation, Treg, IMMUNE; HET: MAN, NAG, BMA; 3.1A {Mus musculus}
Probab=98.95  E-value=1.1e-13  Score=131.18  Aligned_cols=158  Identities=22%  Similarity=0.234  Sum_probs=101.5  Template_Neff=9.600

Q NP_000548.2     143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGN------SSVKLEAGLANTITSFIDKGQDDRG-P  215 (501)
Q Consensus       143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~------~~~~~~~~~~n~Vrsf~~~~~~~~~-~  215 (501)
                      .+||++|||+++|++...    .+.+++++|++||+.+.........      ..+.+....+++|++|......... .
T Consensus        22 ~~IL~~LgL~~~P~~~~~----~~~~~p~~m~~lY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~s~~~~~~~~~~~~   97 (249)
T 6GFF_G           22 GQILSKLRLASPPSQGEV----PPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQ   97 (249)
T ss_dssp             HHHHHHTTCSSCCCSTTC----CSSSCCHHHHHHHHHHHSCCCCC-------CGGGTSCEEEEEEECCCCCCCCHHHSCC
T ss_pred             HHHHHHcCCCCCCCCCCC----CCCCChHHHHHHHHHHHhhccCCCCCCCCCChhhhhhheeEeeEEeeccccccccccc
Confidence            689999999999998651    2235689999999987655321100      0111223456788887654332100 1


Q NP_000548.2     216 VVRKQRYVFDISALE----K-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVPGLDGSG  290 (501)
Q Consensus       216 ~~~~~~l~FnlSsi~----~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~~~~ll~s~~v~~~~~~g  290 (501)
                      ......+.|++++++    . +.|.+|+||||+.....           ...|.||...... ...++..+.+.....++
T Consensus        98 ~~~~~~l~F~ls~~~~~~~~~~~v~~AeL~l~~~~~~~-----------~~~v~iy~~~~~~-~~~~l~~~~v~~~~~~~  165 (249)
T 6GFF_G           98 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKV-----------EQHVELYQKYSNN-SWRYLSNRLLAPSDSPE  165 (249)
T ss_dssp             CTTEEEEEEEHHHHHHHSSSGGGEEEEEEEEEECCBSS-----------CEEEEEEECCSSS-CCEEEEEEEECCBSSCE
T ss_pred             CCCcEEEEeehHHhhccCCCcceEEEEEEEEEEcCCCc-----------eEEEEEEEecCCC-ceeEeEEEEeCCCCCCC
Confidence            234677999999752    2 47999999999987642           3567777643210 11123333221234579


Q NP_000548.2     291 WEVFDIWKLFRNFKNSA--QLCLELEAW  316 (501)
Q Consensus       291 Wv~fDVT~aV~~Wl~~~--nlgL~V~~~  316 (501)
                      |+.||||.+|+.|+.++  +++|.|.+.
T Consensus       166 W~~~dVt~~v~~W~~~~~~n~~l~v~v~  193 (249)
T 6GFF_G          166 WLSFDVTGVVRQWLSRGGEIEGFRLSAH  193 (249)
T ss_dssp             EEEEECHHHHHHHHHSCCSEEEEEEEEC
T ss_pred             eEEEEhHHHHHHHHHcCCCccCEEEEEE
Confidence            99999999999999987  788886554


No 46
>5HLZ_E Inhibin beta A chain; Growth factor, Precursor, Signalling, Signaling; 2.851A {Homo sapiens}
Probab=98.74  E-value=1.8e-12  Score=124.55  Aligned_cols=155  Identities=15%  Similarity=0.223  Sum_probs=99.6  Template_Neff=9.000

Q NP_000548.2     143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGG------N----SSVKLEAGLANTITSFIDKGQDD  212 (501)
Q Consensus       143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~------~----~~~~~~~~~~n~Vrsf~~~~~~~  212 (501)
                      .+||++|||+.+|+++..    .+  .+++|++||+.+........      +    ..++.....+++|++|.+.+.  
T Consensus        41 ~~IL~~LGl~~~P~~~~~----~~--~p~~M~~LY~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~I~sf~~~~~--  112 (270)
T 5HLZ_E           41 KHILNMLHLKKRPDVTQP----VP--KAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGT--  112 (270)
T ss_pred             HHHHHHcCCCCCCCCCCC----CC--hHHHHHHHHHhhcCcccCCCceeccccccchhhhhhhhcceEEEEEEecCCC--
Confidence            689999999999998651    11  38999999998765442100      0    001123345678888876532  


Q NP_000548.2     213 RGPVVRKQRYVFDISA-LEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGR------------------  272 (501)
Q Consensus       213 ~~~~~~~~~l~FnlSs-i~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~------------------  272 (501)
                           ....+.|+++. .+. +.|.+|+||||+.......      ......+.||......                  
T Consensus       113 -----~~~~l~F~~s~~~~~~~~v~~AeL~l~~~~~~~~~------~~~~~~i~vy~~~~~~~~~~~~~~~~~~~g~~~~  181 (270)
T 5HLZ_E          113 -----ARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANR------TRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGE  181 (270)
T ss_pred             -----ccEEEEEEecCCCCCceeEEEEEEEEEEeCCCcCC------CcceEEEEEEEEeeCCCCCCCCCchhhhhcCCcc
Confidence                 34578999987 433 4699999999998764310      1124566777543210                  


Q NP_000548.2     273 QPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSA--QLCLELEAWE  317 (501)
Q Consensus       273 ~~~~ll~s~~v~~~~~~gWv~fDVT~aV~~Wl~~~--nlgL~V~~~~  317 (501)
                      ....++.++.+ .....+|++|||+.+|+.|+..+  +++|.|.+..
T Consensus       182 ~~~~ll~s~~v-~~~~~gW~~fdVt~~v~~W~~~~~~n~gl~v~~~~  227 (270)
T 5HLZ_E          182 RSELLLSEKVV-DARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQ  227 (270)
T ss_pred             ceEEEEEEEEe-ecCCCceEEEEChHHHHHHHHcCCCCeeEEEEEEe
Confidence            01112333333 23457999999999999999986  7898887754


No 47
>4YCG_B pro-BMP9 prodomain, human BMP9 growth; pro-BMP complex, morphogen, transforming growth; HET: NAG, ZN; 3.3A {Mus musculus}
Probab=98.69  E-value=3.5e-12  Score=124.35  Aligned_cols=152  Identities=18%  Similarity=0.323  Sum_probs=81.5  Template_Neff=8.500

Q NP_000548.2     143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG----PVVR  218 (501)
Q Consensus       143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~----~~~~  218 (501)
                      .+||++|||.++|++...     ...+++||++||+.+......         ...+++|++|.+.......    ....
T Consensus        41 ~~IL~~LgL~~~P~~~~~-----~~~~p~yMl~LY~~~~~~~~~---------~~~~ntvRsf~~~~~~~~~~~~~~~~~  106 (296)
T 4YCG_B           41 VDFLRSLNLSGIPSQDKT-----RAEPPQYMIDLYNRYTTDKSS---------TPASNIVRSFSVEDAISTAATEDFPFQ  106 (296)
T ss_dssp             -------------------------CCCHHHHHHHHHHHHCTTS---------CCSCSEEEEEECCEEEEECCCSSSCSE
T ss_pred             HHHHHHCCCCCCCCCCCC-----CCCCCHHHHHHHHHhhcCCCC---------CCCccceeeeehhhhcccccCCCCCCC
Confidence            589999999999997641     124589999999987655321         1245677777654332110    0124


Q NP_000548.2     219 KQRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQ-------PAALLDVRSVPGLDGSG  290 (501)
Q Consensus       219 ~~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~-------~~~ll~s~~v~~~~~~g  290 (501)
                      ...+.|+++ ++. +.|..|+||||+........    .......|.||.......       ...++...   .....+
T Consensus       107 ~~~L~F~lS-~p~~e~v~~AeLrl~~~~~~~~~~----~~~~~~~V~Vy~v~~~~~~~~~~~~~~~lL~~~---~~~~~g  178 (296)
T 4YCG_B          107 KHILIFNIS-IPRHEQITRAELRLYVSCQNDVDS----THGLEGSMVVYDVLEDSETWDQATGTKTFLVSQ---DIRDEG  178 (296)
T ss_dssp             EEEEECCCC-CCTTEEEEEEEEEEEEEECSCTTG----GGCCCEEEEEEEEEECCSSCSSSSSEEEEEEEE---EECSSE
T ss_pred             cEEEEEEEe-cCchhceEEEEEEEEeecCCCccC----CCCcEEEEEEEEeccccccccccCCcEEEEEEE---EcCCCe
Confidence            567899998 653 68999999999887643110    011245677776432100       01112222   234579


Q NP_000548.2     291 WEVFDIWKLFRNFKNSA----QLCLELEAW  316 (501)
Q Consensus       291 Wv~fDVT~aV~~Wl~~~----nlgL~V~~~  316 (501)
                      |+.||||.+|+.|+.++    +++|+|.+.
T Consensus       179 W~~fDVT~~V~~W~~~~~~~~~~gL~v~~~  208 (296)
T 4YCG_B          179 WETLEVSSAVKRWVRADSTTNKNKLEVTVQ  208 (296)
T ss_dssp             EEEEECHHHHHHHHSCCSSSCCSEEEEEEE
T ss_pred             eEEEEhHHHHHHHHHCCCCCCCceEEEEEE
Confidence            99999999999999985    478887664


No 48
>4YCI_B mouse pro-BMP9 prodomain, pro-BMP9 growth; pro-BMP complex, morphogen, transforming growth; HET: ZN, NAG; 3.25A {Mus musculus}
Probab=98.69  E-value=3.5e-12  Score=124.35  Aligned_cols=152  Identities=18%  Similarity=0.323  Sum_probs=81.5  Template_Neff=8.500

Q NP_000548.2     143 SFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRG----PVVR  218 (501)
Q Consensus       143 ~qIL~kLGL~~~P~~~~~~~~~~~~~~p~~MldLY~~~~~~~~~~~~~~~~~~~~~~n~Vrsf~~~~~~~~~----~~~~  218 (501)
                      .+||++|||.++|++...     ...+++||++||+.+......         ...+++|++|.+.......    ....
T Consensus        41 ~~IL~~LgL~~~P~~~~~-----~~~~p~yMl~LY~~~~~~~~~---------~~~~ntvRsf~~~~~~~~~~~~~~~~~  106 (296)
T 4YCI_B           41 VDFLRSLNLSGIPSQDKT-----RAEPPQYMIDLYNRYTTDKSS---------TPASNIVRSFSVEDAISTAATEDFPFQ  106 (296)
T ss_dssp             -------------------------CCCHHHHHHHHHHHHCTTS---------CCSCSEEEEEECCEEEEECCCSSSCSE
T ss_pred             HHHHHHCCCCCCCCCCCC-----CCCCCHHHHHHHHHhhcCCCC---------CCCccceeeeehhhhcccccCCCCCCC
Confidence            589999999999997641     124589999999987655321         1245677777654332110    0124


Q NP_000548.2     219 KQRYVFDISALEK-DGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQ-------PAALLDVRSVPGLDGSG  290 (501)
Q Consensus       219 ~~~l~FnlSsi~~-e~V~~AeLrLy~~~~~~~~~~~~~~~~~~~~v~Vy~~~~~~~-------~~~ll~s~~v~~~~~~g  290 (501)
                      ...+.|+++ ++. +.|..|+||||+........    .......|.||.......       ...++...   .....+
T Consensus       107 ~~~L~F~lS-~p~~e~v~~AeLrl~~~~~~~~~~----~~~~~~~V~Vy~v~~~~~~~~~~~~~~~lL~~~---~~~~~g  178 (296)
T 4YCI_B          107 KHILIFNIS-IPRHEQITRAELRLYVSCQNDVDS----THGLEGSMVVYDVLEDSETWDQATGTKTFLVSQ---DIRDEG  178 (296)
T ss_dssp             EEEEECCCC-CCTTEEEEEEEEEEEEEECSCTTC----TTCCCEEEEEEEEEECCSSCSTTSSEEEEEEEE---EECSSE
T ss_pred             cEEEEEEEe-cCchhceEEEEEEEEeecCCCccC----CCCcEEEEEEEEeccccccccccCCcEEEEEEE---EcCCCe
Confidence            567899998 653 68999999999887643110    011245677776432100       01112222   234579


Q NP_000548.2     291 WEVFDIWKLFRNFKNSA----QLCLELEAW  316 (501)
Q Consensus       291 Wv~fDVT~aV~~Wl~~~----nlgL~V~~~  316 (501)
                      |+.||||.+|+.|+.++    +++|+|.+.
T Consensus       179 W~~fDVT~~V~~W~~~~~~~~~~gL~v~~~  208 (296)
T 4YCI_B          179 WETLEVSSAVKRWVRADSTTNKNKLEVTVQ  208 (296)
T ss_dssp             EEEEECHHHHHHHHSCTTSSCCSEEEEEEE
T ss_pred             eEEEEhHHHHHHHHHCCCCCCCceEEEEEE
Confidence            99999999999999985    478887664


No 49
>4NT5_A von Willebrand factor; cystine knot, dimerization of VWF; HET: SO4, NAG; 3.281A {Homo sapiens}
Probab=75.72  E-value=0.27  Score=37.97  Aligned_cols=65  Identities=22%  Similarity=0.456  Sum_probs=39.6  Template_Neff=7.800

Q NP_000548.2     422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       422 ~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ..+..++|.|.|......     +...  .      .....-.||.|.++....|...=.+|..  ..+.=+++.+|+|.
T Consensus        37 ~~v~~~~C~G~C~S~~~~-----~~~~--~------~~~~~c~CC~p~~~~~~~v~L~C~~g~~--~~~~~~~i~~C~C~  101 (107)
T 4NT5_A           37 VEVDIHYCQGKCASKAMY-----SIDI--N------DVQDQCSCCSPTRTEPMQVALHCTNGSV--VYHEVLNAMECKCS  101 (107)
T ss_dssp             SCEEEEECCCBCCEEEEE-----ETTT--T------EEEEEEEEEEESSEEEEEEEEECTTSCE--EEEEEEEECCEEEE
T ss_pred             eeeeceEEeEeecCceee-----cCCc--c------ceEeecCcccCeEeEeEEEEEECCCCCE--EEEEEEeeeeceEE
Confidence            567889999999875321     1100  0      0123578999999987776444333332  23344678899994


No 50
>2KD3_A Sclerostin; Protein, antagonist of CYTOKINE, PROTEIN; NMR {Mus musculus}
Probab=73.48  E-value=0.35  Score=38.01  Aligned_cols=73  Identities=15%  Similarity=0.291  Sum_probs=40.9  Template_Neff=6.600

Q NP_000548.2     419 IAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANN-VVYKQYEDMVVES  497 (501)
Q Consensus       419 iaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~-~~~~~~~~mvv~~  497 (501)
                      ++.+.+...+|.|.|.......   ...... ... .   ......||.|.++....|.+.=.+|. .+  ...-+.|.+
T Consensus        39 ~S~~~v~~~~C~G~C~s~s~~~---~~~~~~-~~~-~---~~~~c~CC~p~~t~~r~V~l~C~dG~~~~--~~~~~~V~~  108 (113)
T 2KD3_A           39 RSAKPVTELVCSGQCGPARLLP---NAIGRV-KWW-R---PNGPDFRCIPDRYRAQRVQLLCPGGAAPR--SRKVRLVAS  108 (113)
T ss_dssp             EECCCCCBCCCCCCCSCCCCCC---CCTTCC-SSS-C---SSCCCCCCEEEEEEEEEEEEECTTSEE------EEEEEEE
T ss_pred             eeCCccccceeeeeCCCCccCC---cccCCC-Ccc-c---ccCCCccccCceeEEEEEEEECCCCCeeE--EEEeEEEee
Confidence            4456678889999998653210   000000 000 0   12357899999999877655433342 22  334468899


Q NP_000548.2     498 CGCR  501 (501)
Q Consensus       498 CgC~  501 (501)
                      |+|.
T Consensus       109 C~C~  112 (113)
T 2KD3_A          109 CKCK  112 (113)
T ss_dssp             EECC
T ss_pred             cccC
Confidence            9994


No 51
>4YU8_A Neuroblastoma suppressor of tumorigenicity 1; BMP Binding Protein, NBL1 DAN; HET: NAG; 1.8A {Homo sapiens}
Probab=70.00  E-value=0.48  Score=38.53  Aligned_cols=88  Identities=13%  Similarity=0.121  Sum_probs=41.4  Template_Neff=7.100

Q NP_000548.2     398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL  477 (501)
Q Consensus       398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il  477 (501)
                      ..|....+...+..=|   - . +..+..++|.|.|.......    ...   ...    .....-.||.|.++....|-
T Consensus        32 ~~C~~~~~~~~I~~~g---C-~-s~~V~~~~C~G~C~S~s~~~----~~~---~~~----~~~~~CsCC~p~~~~~~~V~   95 (139)
T 4YU8_A           32 AWCEAKNITQIVGHSG---C-E-AKSIQNRACLGQCFSYSVPN----TFP---QST----ESLVHCDSCMPAQSMWEIVT   95 (139)
T ss_dssp             CEEEEEEEEEEECCTT---S-C-CEEEEEEEEEEECCC------------------------------EEEEEEEEEEEE
T ss_pred             CccEEEeeEEEEecCC---c-e-eeeeecceeeceecccccCC----CCC---CCc----cceeecCcccCeEEEEEEEE
Confidence            3566555444443211   1 2 25678899999998753210    000   000    01123469999999977664


Q NP_000548.2     478 FIDSANNV-VYKQYEDMVVESCGCR  501 (501)
Q Consensus       478 y~d~~~~~-~~~~~~~mvv~~CgC~  501 (501)
                      ..=.++.. ....+.=..+.+|+|.
T Consensus        96 L~C~~g~~~~~~~~~~~~v~sC~C~  120 (139)
T 4YU8_A           96 LECPGHEEVPRVDKLVEKILHCSCQ  120 (139)
T ss_dssp             EECTTCSSSCEEEEEEEEEEEEEEC
T ss_pred             EeCCCCCCcccEEEEEEeeeecccc
Confidence            33233322 0022333478999995


No 52
>2K8P_A Sclerostin; WNT SIGNALLING PATHWAY, BONE FORMATION; NMR {Homo sapiens}
Probab=66.67  E-value=0.66  Score=39.89  Aligned_cols=74  Identities=18%  Similarity=0.288  Sum_probs=43.0  Template_Neff=5.300

Q NP_000548.2     419 IAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESC  498 (501)
Q Consensus       419 iaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~C  498 (501)
                      .+.+.+...+|.|.|......    .+.. -......   ......||+|.+.....|-+.=.+|. ....+.-|+|.+|
T Consensus        71 ~S~kpV~~~~C~G~C~~~s~~----~~~~-~~~k~~~---~~~~~~CC~P~rTrtrrV~f~C~DGt-~t~~~~v~~V~sC  141 (189)
T 2K8P_A           71 RSAKPVTELVCSGQCGPARLL----PNAI-GRGKWWR---PSGPDFRCIPDRYRAQRVQLLCPGGE-APRARKVRLVASC  141 (189)
T ss_dssp             EESSCEEEEEECCCCCCCCCC----SSCC-CSSCCCS---CCCCCCCCEECCEEEEEEEEECCTTS-CCEEEEEEEECCE
T ss_pred             ecCCceeeeEEeeeCCCcccC----CCcc-cCCCccC---CCCCCCCCCCCeeEEEEEEEECCCCC-cceeEEeeEeeeC
Confidence            556777889999999864321    0100 0000001   12357899999988766655434342 0123345789999


Q NP_000548.2     499 GCR  501 (501)
Q Consensus       499 gC~  501 (501)
                      +|.
T Consensus       142 kCk  144 (189)
T 2K8P_A          142 KCK  144 (189)
T ss_dssp             ECC
T ss_pred             CCc
Confidence            994


No 53
>4JPH_D Gremlin-2; Cystine knot, DAN domain, CAN; HET: GSH, GOL, CIT; 2.25A {Mus musculus}
Probab=65.08  E-value=0.72  Score=37.91  Aligned_cols=88  Identities=14%  Similarity=0.239  Sum_probs=48.1  Template_Neff=6.700

Q NP_000548.2     398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL  477 (501)
Q Consensus       398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il  477 (501)
                      ..|....+...+..=|=    .+ ..+..++|.|.|.......    .......       ....-.||.|.++....|.
T Consensus        51 ~~C~~~~~~q~I~~~gC----~s-~~V~~~~C~G~C~S~s~p~----~~~~~~~-------~~~~CsCC~p~~~~~~~V~  114 (148)
T 4JPH_D           51 DWCKTQPLRQTVSEEGC----RS-RTILNRFCYGQCNSFYIPR----HVKKEED-------SFQSCAFCKPQRVTSVIVE  114 (148)
T ss_dssp             CEEEEEEEEEEECCTTS----CC-EEEEEEEEEEEEEEEEEEC----CCSSSCC-------EEEEEEEEEEEEEEEEEEE
T ss_pred             CceeeEeceEEEccCCc----ee-eeEEeceeeeecCcccccc----cCCCccc-------cccccCcccCeEEEEEEEE
Confidence            45776666555442221    22 4678899999998643210    0000000       1234689999999976664


Q NP_000548.2     478 FIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       478 y~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ..=.++.-......=..|.+|+|.
T Consensus       115 L~C~~g~~~~~~~~v~~V~sC~C~  138 (148)
T 4JPH_D          115 LECPGLDPPFRIKKIQKVKHCRCM  138 (148)
T ss_dssp             ECCTTSSSSCEEEEEEEEEEEEEE
T ss_pred             EeCCCCCCCceEEEEEeeeeCcee
Confidence            332222211122334588999995


No 54
>4X1J_B Neuroblastoma suppressor of tumorigenicity 1; BMP antagonist, DAN family, Cystine-knot; HET: NAG; 2.5A {Homo sapiens}
Probab=64.18  E-value=0.74  Score=35.85  Aligned_cols=88  Identities=13%  Similarity=0.131  Sum_probs=46.1  Template_Neff=7.700

Q NP_000548.2     398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL  477 (501)
Q Consensus       398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il  477 (501)
                      ..|....+...+..=|=     .+..+..++|.|.|.......    ...   ...    .....-.||.|.++....|.
T Consensus        17 ~~C~~~~~~~~i~~~gC-----~s~~i~~~~C~G~C~S~~~~~----~~~---~~~----~~~~~C~CC~p~~~~~~~V~   80 (116)
T 4X1J_B           17 AWCEAKNITQIVGHSGC-----EAKSIQNRACLGQCFSYSVPN----TFP---QST----ESLVHCDSCMPAQSMWEIVT   80 (116)
T ss_dssp             CEEEEEEEEEEECCTTS-----CCEEEEEEEEEEEEEEEECC------------------CTTEEEEEEEEEEEEEEEEE
T ss_pred             CccEEEEeEEEEccCCc-----cceeEecceEeeeeeeeeecC----CCC---CCC----cceeecCCccceEEEEEEEE
Confidence            35666555444432111     123578899999998643210    000   000    01234579999999987764


Q NP_000548.2     478 FIDSANNV-VYKQYEDMVVESCGCR  501 (501)
Q Consensus       478 y~d~~~~~-~~~~~~~mvv~~CgC~  501 (501)
                      ..=.++.- ......=.++.+|+|.
T Consensus        81 L~C~~g~~~~~~~~~~~~v~~C~C~  105 (116)
T 4X1J_B           81 LECPGHEEVPRVDKLVEKILHCSCQ  105 (116)
T ss_dssp             EECTTCSSSSEEEEEEEEEEEEEEE
T ss_pred             EECCCCCCCccEEEEEEeeEecccc
Confidence            43233322 1122333478999995


No 55
>5AEJ_A GREMLIN-1; SIGNALING PROTEIN, SIGNALING, GREMLIN, GROWTH; HET: SO4; 1.904A {HOMO SAPIENS}
Probab=62.64  E-value=0.87  Score=37.64  Aligned_cols=87  Identities=15%  Similarity=0.248  Sum_probs=48.6  Template_Neff=6.100

Q NP_000548.2     397 KARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISI  476 (501)
Q Consensus       397 ~~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~i  476 (501)
                      ...|....+...+..=|=    . +..+..++|.|.|......     ... . ..   . .....-.||.|.++....|
T Consensus        59 ~~~C~~~~~~q~I~~~gC----~-S~~V~~~~C~G~C~S~s~p-----s~~-~-~~---~-~~~~~CsCC~p~~s~~~~V  122 (152)
T 5AEJ_A           59 RDWCKTQPLKQTIHEEGC----N-SRTIINRFCYGQCNSFYIP-----RHI-R-KE---E-GSFQSCSFCKPKKFTTMMV  122 (152)
T ss_dssp             CCEEEEEEEEEEECCTTS----C-CEEEEEEEEEEEEEEEEEE-----EEE-T-TE---E-EEEEEEEEEEEEEEEEEEE
T ss_pred             CCceeeeeceeEEccCCc----e-eceEEeeeceeecccCeec-----ccc-c-cc---C-CceeecCcccceEEEEEEE
Confidence            456877766555542221    2 2568899999999864321     100 0 00   0 0122467999999987666


Q NP_000548.2     477 LFIDSANNV--VYKQYEDMVVESCGCR  501 (501)
Q Consensus       477 ly~d~~~~~--~~~~~~~mvv~~CgC~  501 (501)
                      ...=.++..  +.+.+  ..+.+|.|.
T Consensus       123 ~L~Cpdg~~~~~~~~v--~~V~sC~C~  147 (152)
T 5AEJ_A          123 TLNCPELQPPTKKKRV--TRVKQCRCI  147 (152)
T ss_dssp             EEECTTSSSSEEEEEE--EEEEEEEEE
T ss_pred             EEECCCCCCCceEEEE--EeceeceeE
Confidence            333222322  23333  578999995


No 56
>5HK5_G Gremlin-2, Growth/differentiation factor 5; DAN-family, Bone Morphogenetic Proteins, CYTOKINE; 2.9A {Mus musculus}
Probab=61.90  E-value=0.91  Score=37.23  Aligned_cols=86  Identities=15%  Similarity=0.240  Sum_probs=46.5  Template_Neff=6.600

Q NP_000548.2     398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL  477 (501)
Q Consensus       398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il  477 (501)
                      ..|....+...+..=|=    .+ ..+..++|.|.|.......    .......       ....-.||.|.++....|.
T Consensus        50 ~~C~~~~~~q~I~~~gC----~s-~~V~~~~C~G~C~S~s~ps----~~~~~~~-------~~~~CsCC~p~~~~~~~V~  113 (147)
T 5HK5_G           50 DWCKTQPLRQTVSEEGC----RS-RTILNRFCYGQCNSFYIPR----HVKKEED-------SFQSCAFCKPQRVTSVIVE  113 (147)
T ss_pred             CceeeEeceEEEccCCc----ee-eeEEeceeeeecCcccccc----cCCCccc-------cccccCcccCeEEEEEEEE
Confidence            35665555544432121    22 4578899999998643210    0000000       1234679999999976663


Q NP_000548.2     478 FIDSANNV--VYKQYEDMVVESCGCR  501 (501)
Q Consensus       478 y~d~~~~~--~~~~~~~mvv~~CgC~  501 (501)
                      ..=.++..  +.+.  =.+|.+|+|.
T Consensus       114 L~C~dg~~~~~~~~--~~~V~sC~C~  137 (147)
T 5HK5_G          114 LECPGLDPPFRIKK--IQKVKHCRCM  137 (147)
T ss_pred             EeCCCCCCCceEEE--EEeeeeCcee
Confidence            33222221  2333  3578999994


No 57
>5BPU_A Frizzled-4; Wnt signalling pathway, Norrie disease; HET: GGL; 2.4A {Homo sapiens}
Probab=57.82  E-value=1.2  Score=34.98  Aligned_cols=72  Identities=21%  Similarity=0.280  Sum_probs=38.3  Template_Neff=7.700

Q NP_000548.2     422 LEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       422 ~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~ily~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ..+..++|.|.|.......    ........  ........-.||.|.++....+...=.++..+.  ..-.++.+|.|.
T Consensus        37 ~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~v~l~C~~g~~~~--~~~~~i~~C~C~  108 (122)
T 5BPU_A           37 KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLT--ATYRYILSCHCE  108 (122)
T ss_pred             CcEeceeeeccccceeecC----CCcccCCC--CCCcceeeeecCcCeEeEEEEEEEECCCCCeEE--EEEEEEEeceee
Confidence            6678899999998753200    00000000  000012345899999988766533323332222  333478899994


No 58
>5BQ8_C Norrin; Wnt signalling pathway, Norrie disease; HET: MLY; 2.0A {Homo sapiens}
Probab=53.96  E-value=1.5  Score=34.27  Aligned_cols=93  Identities=19%  Similarity=0.268  Sum_probs=46.5  Template_Neff=7.800

Q NP_000548.2     398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL  477 (501)
Q Consensus       398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il  477 (501)
                      ..|....+...+..=.. .- .. ..+..++|.|.|.......    ........  ........-.||.|.++....|.
T Consensus        16 ~~C~~~~~~~~i~~~~~-gC-~s-~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~V~   86 (122)
T 5BQ8_C           16 RRCMRHHYVDSISHPLY-KC-SS-KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALR   86 (122)
T ss_dssp             TSSEEEEEEEEECCSSS-CB-CC-EEEEEEEEEECCSSCEEEE----ECCEETTB--CCCSEEEECEEEEEEEEEEEEEE
T ss_pred             CCeEEEeeEEEEEcCCC-Cc-ee-ceeEeeeEEEecccceecC----CccccCCC--CCCCceeEceecCCeEeEEEEEE
Confidence            45666555444432100 11 22 6678899999998753200    00000000  00001234589999998876653


Q NP_000548.2     478 FIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       478 y~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ..=.++..+  ...-+++.+|.|.
T Consensus        87 l~C~~g~~~--~~~~~~i~~C~C~  108 (122)
T 5BQ8_C           87 LRCSGGMRL--TATYRYILSCHCE  108 (122)
T ss_dssp             EEETTTEEE--EEEEEEEEEEEEE
T ss_pred             EECCCCceE--EEEEEEEEeceee
Confidence            332333322  2334578999994


No 59
>5BQE_A Frizzled-4; Wnt signalling pathway, Norrie disease; HET: MLY, NAG, PG0; 2.3A {Homo sapiens}
Probab=53.96  E-value=1.5  Score=34.27  Aligned_cols=93  Identities=19%  Similarity=0.268  Sum_probs=46.5  Template_Neff=7.800

Q NP_000548.2     398 ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISIL  477 (501)
Q Consensus       398 ~~Cc~~~l~V~F~dlGW~~wIiaP~~~~a~yC~G~C~~~~~~~~~~~~h~~i~~~~~~~~~~~~~~pCC~P~~~~~l~il  477 (501)
                      ..|....+...+..=.. .- .. ..+..++|.|.|.......    ........  ........-.||.|.++....|.
T Consensus        16 ~~C~~~~~~~~i~~~~~-gC-~s-~~v~~~~C~G~C~S~~~~~----p~~~~~~~--~~~~~~~~C~CC~p~~~~~~~V~   86 (122)
T 5BQE_A           16 RRCMRHHYVDSISHPLY-KC-SS-KMVLLARCEGHCSQASRSE----PLVSFSTV--LKQPFRSSCHCCRPQTSKLKALR   86 (122)
T ss_dssp             TSSEEEEEEEEECCSSS-CB-CC-EEEEEEEEEECCSSCEEEE----ECCBCSSS--CSSCEEEECEEEEEEEEEEEEEE
T ss_pred             CCeEEEeeEEEEEcCCC-Cc-ee-ceeEeeeEEEecccceecC----CccccCCC--CCCCceeEceecCCeEeEEEEEE
Confidence            45666555444432100 11 22 6678899999998753200    00000000  00001234589999998876653


Q NP_000548.2     478 FIDSANNVVYKQYEDMVVESCGCR  501 (501)
Q Consensus       478 y~d~~~~~~~~~~~~mvv~~CgC~  501 (501)
                      ..=.++..+  ...-+++.+|.|.
T Consensus        87 l~C~~g~~~--~~~~~~i~~C~C~  108 (122)
T 5BQE_A           87 LRCSGGMRL--TATYRYILSCHCE  108 (122)
T ss_dssp             EEBSSSCEE--EEEEEEEEEEEEE
T ss_pred             EECCCCceE--EEEEEEEEeceee
Confidence            332333322  2334578999994