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view test-data/model/hhr.ffdata @ 39:172398348efd draft
"planemo upload commit 26b4018c88041ee0ca7c2976e0a012015173d7b6-dirty"
| author | guerler |
|---|---|
| date | Fri, 22 Jan 2021 15:50:27 +0000 |
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Query sp|Q9BYF1|ACE2_HUMAN Angiotensin-converting enzyme 2 OS=Homo sapiens (Human) OX=9606 GN=ACE2 PE=1 SV=2 Match_columns 805 No_of_seqs 1 out of 1 Neff 1 Searched_HMMs 82491 Date Sat Oct 10 23:55:36 2020 Command hhsearch -e 0.001 -i /galaxy-repl/main/files/046/047/dataset_46047478.dat -d hhdb -o /galaxy-repl/main/files/046/091/dataset_46091622.dat No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 6M18_B Sodium-dependent neutra 100.0 4E-194 5E-199 1504.8 0.0 804 2-805 3-814 (814) 2 1R42_A angiotensin I convertin 100.0 3.4E-78 4.2E-83 582.0 0.0 615 1-615 1-615 (615) 3 6LZG_A Angiotensin-converting 100.0 5.4E-74 6.6E-79 545.9 0.0 597 19-615 1-597 (597) 4 3D0I_B Crystal structure of sp 100.0 1.2E-73 1.5E-78 545.2 0.0 596 20-615 2-597 (597) 5 5AMB_A ANGIOTENSIN-CONVERTING 100.0 1.2E-69 1.5E-74 524.2 0.0 595 20-625 12-614 (629) 6 6H5W_A Angiotensin-converting 100.0 4.4E-61 5.4E-66 455.7 0.0 579 22-613 5-588 (591) 7 6S1Y_A Angiotensin-converting 100.0 4.6E-59 5.5E-64 450.3 0.0 579 21-610 11-600 (621) 8 4CA5_A ANGIOTENSIN-CONVERTING 100.0 3.9E-58 4.7E-63 435.5 0.0 578 22-612 5-587 (589) 9 5A2R_A ANGIOTENSIN-CONVERTING 100.0 2.8E-56 3.4E-61 425.1 0.0 579 22-611 5-594 (598) 10 4ASR_A ANGIOTENSIN-CONVERTING 100.0 2.9E-56 3.5E-61 426.4 0.0 578 22-611 6-595 (598) 11 4CA7_A ANGIOTENSIN-CONVERTING 100.0 3.2E-56 3.9E-61 426.0 0.0 578 22-611 6-595 (598) 12 2C6F_A ANGIOTENSIN-CONVERTING 100.0 2.3E-52 2.7E-57 400.7 0.0 579 22-611 14-599 (612) 13 5GIV_E Carboxypeptidase; M32 c 100.0 4.3E-52 5.2E-57 399.6 0.0 474 19-597 3-502 (503) 14 5GIV_F Carboxypeptidase; M32 c 100.0 4.3E-52 5.2E-57 399.6 0.0 474 19-597 3-502 (503) 15 3HQ2_B Bacillus subtilis M32 c 100.0 1.1E-47 1.3E-52 361.2 0.0 473 22-597 3-500 (501) 16 1K9X_B m32 carboxypeptidase; H 100.0 1.1E-46 1.3E-51 357.8 0.0 470 20-593 4-499 (499) 17 1KA2_A M32 carboxypeptidase; H 100.0 1.1E-46 1.3E-51 357.8 0.0 470 20-593 4-499 (499) 18 5E3X_A Thermostable carboxypep 100.0 2.4E-46 2.9E-51 356.7 0.0 456 27-597 2-486 (489) 19 3HOA_A Thermostable carboxypep 100.0 1.1E-45 1.3E-50 356.9 0.0 468 22-594 3-507 (509) 20 3DWC_B Metallocarboxypeptidase 100.0 2E-44 2.4E-49 343.9 0.0 459 23-593 3-501 (505) 21 5WVU_C Thermostable carboxypep 100.0 8.4E-44 1E-48 344.0 0.0 469 22-595 3-508 (510) 22 3SKS_A Putative Oligoendopepti 100.0 1.7E-38 2.1E-43 300.7 0.0 506 22-600 36-564 (567) 23 3AHN_A Oligopeptidase; HYDROLA 100.0 2.6E-38 3.2E-43 299.3 0.0 505 22-601 33-562 (564) 24 2QR4_A Peptidase M3B, oligoend 100.0 2E-33 2.4E-38 267.6 0.0 506 23-603 34-578 (587) 25 2O36_A Thimet oligopeptidase ( 99.9 5E-30 6.1E-35 254.5 0.0 518 26-588 47-660 (674) 26 3CE2_A Crystal structure of pu 99.9 1.1E-29 1.4E-34 244.3 0.0 507 23-601 67-609 (618) 27 2O3E_A Neurolysin (E.C.3.4.24. 99.9 9.4E-29 1.1E-33 246.4 0.0 515 31-588 68-676 (678) 28 5LV0_A Neurolysin, mitochondri 99.9 6.2E-28 7.6E-33 240.2 0.0 504 41-589 83-682 (686) 29 1S4B_P Thimet oligopeptidase ( 99.9 1.6E-27 2E-32 236.8 0.0 516 26-588 47-660 (674) 30 5L44_A K-26 dipeptidyl carboxy 99.8 4.9E-23 6E-28 205.4 0.0 512 28-589 76-681 (683) 31 5L43_B K-26 dipeptidyl carboxy 99.8 4.9E-23 6E-28 205.4 0.0 512 28-589 76-681 (683) 32 1Y79_1 Peptidyl-Dipeptidase Dc 99.4 4.5E-17 5.4E-22 163.2 0.0 501 41-588 70-676 (680) 33 4KA7_A Oligopeptidase A, short 99.4 5.8E-17 7.1E-22 163.7 0.0 407 144-589 239-706 (714) 34 2KNC_B Integrin alpha-IIb, Int 92.7 0.036 4.4E-07 45.3 0.0 31 733-763 2-32 (79) 35 2L8S_A Integrin alpha-1; Integ 87.6 0.29 3.5E-06 40.2 0.0 43 736-778 4-48 (54) 36 2N2A_B Receptor tyrosine-prote 86.5 0.38 4.6E-06 38.4 0.0 30 742-771 9-38 (58) 37 2KNC_A Integrin alpha-IIb, Int 85.7 0.45 5.4E-06 38.7 0.0 40 735-774 6-47 (54) 38 2M3E_A Integrin alpha-L; integ 85.4 0.48 5.8E-06 38.2 0.0 39 736-774 7-47 (50) 39 6J8H_C Sodium channel subunit 84.3 0.6 7.2E-06 37.2 0.0 8 591-598 64-71 (215) 40 2N9Y_B Integrin alpha-IIb, Int 84.0 0.63 7.7E-06 35.0 0.0 30 737-766 5-34 (43) 41 6JXR_n T-cell surface glycopro 83.4 0.7 8.5E-06 38.0 0.0 7 591-597 154-160 (291) 42 2K9J_A Integrin alpha-IIb ligh 83.0 0.74 9E-06 35.9 0.0 39 732-770 1-41 (42) 43 2N5S_A Epidermal growth factor 82.7 0.79 9.6E-06 34.0 0.0 10 744-753 8-17 (54) 44 4UM8_D INTEGRIN ALPHA-V, INTEG 80.8 1 1.3E-05 49.0 0.0 25 738-762 705-729 (788) 45 4UM8_B INTEGRIN ALPHA-V, INTEG 78.7 1.4 1.7E-05 48.1 0.0 25 738-762 705-729 (788) 46 1AFO_A GLYCOPHORIN A; INTEGRAL 75.9 1.9 2.3E-05 35.5 0.0 37 732-771 4-40 (40) 47 6A69_B Plasma membrane calcium 75.9 1.9 2.3E-05 35.7 0.0 15 742-756 224-238 (282) 48 6AGF_B Sodium channel protein 75.3 2 2.5E-05 35.7 0.0 22 773-795 192-213 (218) 49 6J8J_B Sodium channel subunit 75.3 2 2.5E-05 35.7 0.0 22 773-795 192-213 (218) 50 6C14_A Protocadherin-15, LHFPL 74.5 2.2 2.7E-05 40.6 0.0 23 738-760 238-260 (337) 51 6UJB_B Integrin alpha-V, Integ 73.3 2.5 3E-05 45.8 0.0 25 738-762 637-661 (727) 52 6UJA_B Integrin alpha-V, Integ 73.3 2.5 3E-05 45.8 0.0 25 738-762 637-661 (727) 53 2M20_A Epidermal growth factor 72.7 2.6 3.2E-05 32.9 0.0 10 744-753 5-14 (60) 54 5OR7_C Capsid protein, CMRF35- 72.6 2.7 3.2E-05 38.5 0.0 6 592-597 52-57 (330) 55 2MFR_A Insulin receptor (E.C.2 69.0 3.6 4.4E-05 33.9 0.0 38 740-779 15-52 (57) 56 4U0Q_B Plasmodium falciparum R 67.3 4.2 5.1E-05 33.8 0.0 13 744-756 211-223 (269) 57 5A2F_A CD166 ANTIGEN; CELL ADH 63.7 5.5 6.7E-05 38.7 0.0 11 589-599 442-452 (583) 58 2KLU_A T-cell surface glycopro 59.8 7.3 8.8E-05 30.3 0.0 9 744-752 12-20 (70) 59 6ENY_C Beta-2-microglobulin, T 58.0 8.2 9.9E-05 37.8 0.0 9 539-547 248-256 (428) 60 1S7Q_A H-2 class I histocompat 57.9 8.2 0.0001 37.5 0.0 11 742-752 285-295 (348) 61 1S7S_A H-2 class I histocompat 57.9 8.2 0.0001 37.5 0.0 11 742-752 285-295 (348) 62 2WY3_A MHC CLASS I POLYPEPTIDE 57.3 8.6 0.0001 35.8 0.0 9 591-599 214-222 (319) 63 6JXR_f T-cell surface glycopro 55.1 9.8 0.00012 32.9 0.0 14 741-754 130-143 (207) 64 3LB6_C Interleukin-13, Interle 54.8 10 0.00012 33.3 0.0 18 670-687 293-310 (380) 65 3LB6_D Interleukin-13, Interle 54.8 10 0.00012 33.3 0.0 18 670-687 293-310 (380) 66 6FGB_A IgG receptor FcRn large 49.5 14 0.00017 35.5 0.0 10 776-785 311-320 (342) 67 4NKQ_B Cytokine receptor commo 46.9 16 0.0002 32.2 0.0 18 670-687 186-203 (305) 68 6JXR_g T-cell surface glycopro 43.8 20 0.00024 29.7 0.0 10 743-752 117-126 (182) 69 5EH6_A Glycophorin-A; Receptor 43.3 20 0.00025 28.5 0.0 24 741-766 4-27 (30) 70 5EH4_C Glycophorin-A; Receptor 43.3 20 0.00025 28.5 0.0 24 741-766 4-27 (30) 71 2XQ2_A SODIUM/GLUCOSE COTRANSP 39.8 25 0.0003 38.0 0.0 33 739-773 548-580 (593) 72 2RDD_B Acriflavine resistance 39.2 26 0.00031 26.1 0.0 20 756-775 12-31 (37) 73 6CPL_A HLA class II histocompa 39.1 26 0.00031 31.3 0.0 8 591-598 118-125 (229) 74 6EJ2_A Beta-secretase 1 (E.C.3 38.0 28 0.00034 35.2 0.0 15 736-750 452-466 (501) 75 6ENY_F Beta-2-microglobulin, T 37.9 28 0.00034 33.9 0.0 6 592-597 215-220 (341) 76 5XTH_0 NADH dehydrogenase [ubi 37.1 29 0.00035 33.4 0.0 32 732-763 65-96 (144) 77 5B1A_D Cytochrome c oxidase su 33.8 36 0.00044 33.1 0.0 32 732-763 68-99 (147) 78 6PY2_A HLA class II histocompa 33.3 37 0.00045 31.4 0.0 9 591-599 143-151 (254) 79 6GJE_A Protein amnionless, Cub 33.2 37 0.00045 37.8 0.0 18 783-800 399-416 (453) 80 6C13_A Protocadherin-15; PCDH1 32.9 38 0.00046 35.0 0.0 13 693-705 508-520 (660) 81 5DJQ_P Cbb3-type cytochrome c 32.8 38 0.00046 27.7 0.0 24 748-771 7-35 (36) 82 1CD1_A CD1; CD1, IMMUNOLOGY, M 32.5 39 0.00047 31.8 0.0 7 592-598 217-223 (315) 83 6AT5_A HLA class I histocompat 29.9 46 0.00056 33.0 0.0 8 591-598 238-245 (362) 84 4JIX_A Uncharacterized protein 28.2 51 0.00062 27.7 0.0 41 371-421 68-108 (112) 85 4JIX_B Projannalysin; Hydrolas 28.2 51 0.00062 27.7 0.0 41 371-421 68-108 (112) 86 6IDF_E Nicastrin, Presenilin-1 27.6 53 0.00065 31.8 0.0 16 733-748 9-24 (129) 87 6IVA_D Oxaloacetate decarboxyl 26.5 58 0.0007 29.7 0.0 27 738-764 31-57 (104) 88 6IWW_B Oxaloacetate decarboxyl 26.5 58 0.0007 29.7 0.0 27 738-764 31-57 (104) 89 6BRJ_A Epithelial discoidin do 25.3 63 0.00076 37.1 0.0 7 602-608 254-260 (876) 90 3EHB_B Cytochrome c oxidase su 25.2 63 0.00076 33.8 0.0 47 725-771 47-93 (298) 91 6PY2_B HLA class II histocompa 24.3 67 0.00082 30.1 0.0 11 745-755 235-245 (261) 92 1Q5B_C EP-cadherin, ectodomain 24.1 68 0.00082 35.0 0.0 12 155-166 149-160 (880) 93 2JO1_A Phospholemman; FXYD1, N 23.9 69 0.00084 29.3 0.0 30 747-776 20-49 (72) 94 2KV5_A Putative uncharacterize 23.5 71 0.00086 25.4 0.0 27 745-771 4-31 (33) 95 6BSD_A Epithelial discoidin do 23.3 72 0.00088 36.6 0.0 7 602-608 254-260 (876) 96 6KOE_F AA3-600 quinol oxidase 22.6 76 0.00092 33.7 0.0 40 732-771 11-50 (296) 97 6KOB_B AA3-600 quinol oxidase 22.6 76 0.00092 33.7 0.0 40 732-771 11-50 (296) 98 1Q90_G Apocytochrome f, Cytoch 22.4 78 0.00094 26.3 0.0 29 744-772 5-33 (37) 99 2GSM_B Cytochrome c oxidase su 21.9 80 0.00097 31.8 0.0 6 721-726 4-9 (262) 100 3HB3_B Cytochrome c oxidase su 21.5 83 0.001 32.9 0.0 47 725-772 47-94 (298) 101 5X5V_A GD; herpes simplex viru 20.1 93 0.0011 35.6 0.0 28 742-769 355-382 (402) No 1 >6M18_B Sodium-dependent neutral amino acid transporter; ACE2-B0AT1 complex, MEMBRANE PROTEIN; HET: 3PH, NAG; 2.9A {Homo sapiens} Probab=100.00 E-value=3.9e-194 Score=1504.77 Aligned_cols=804 Identities=100% Similarity=1.532 Sum_probs=737.6 Template_Neff=7.700 Q sp|Q9BYF1|ACE2 2 SSSSWLLLSLVAVTAA--------QSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFL 73 (805) Q Consensus 2 sssswlllslvavtaa--------qstieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsafl 73 (805) +.+.|++++||+++++ +++.|++|++||++++.+++++.+++++|+|+|+||+|+++.+.++.+..+|++|+ T Consensus 3 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~e~~a~~~L~~~d~~~~~l~~~~~~A~w~y~tn~t~e~~~~~~ea~~~ls~f~ 82 (814) T 6M18_B 3 SSSSWLLLSLVAVTAAWSHPQFEKQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFL 82 (814) T ss_dssp ---------------------------CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCSTTHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHhcCCcccCCCCCcHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHH Confidence 4678999999999999 99999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 74 KEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMA 153 (805) Q Consensus 74 keqstlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneima 153 (805) ++.++.++.|+++.+++-..|.||+.+++.|...|++++.++++.+++.|+++|+++.+|.+++|.+|+.++|++..+|+ T Consensus 83 ~~~~~~~~~~~~~~~~d~~~kr~L~~l~~~~~~~Ls~~~~~~l~~~~~~m~~~ys~~~v~~~~~p~~~~~L~~~l~~il~ 162 (814) T 6M18_B 83 KEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMA 162 (814) T ss_dssp HHHHHHGGGSCTTSCCCHHHHHHHHHHHCCGGGGSCTTHHHHHHHHHHHHHHHHHHCEEECSSCTTCEEECCCCCHHHHH T ss_pred HHHHHHHhhcChhhcCCHHHHHHHHHHHHcCccCCCHHHHHHHHHHHHHHHHHHHcCCcCCCCCCCcccccCHHHHHHHh Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 154 NSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEI 233 (805) Q Consensus 154 nsldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeei 233 (805) ++-|+.+|.++|+.|++.+++.++|+|+++|-++|++|+.+.|+||+|||+.+|+.++.++|||++.++.+.++..+++| T Consensus 163 ~s~D~~~R~~aw~a~~~~~~~~~~~~l~~lv~lrne~Akl~Gy~sy~d~~l~~~e~~~~~~~~ys~~~~~~~Le~L~~~i 242 (814) T 6M18_B 163 NSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEI 242 (814) T ss_dssp HCCCHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHTTTCSSHHHHHGGGGCBCSSSSCCBCSSHHHHHHHHHHHHH T ss_pred cCCCHHHHHHHHHHHHhHhcHHhHHHHHHHHHHHHHHHHhCCCCCHHHHHHhhhccCCCCCCCCCHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 234 KPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEK 313 (805) Q Consensus 234 kplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaek 313 (805) +|+|+.||+|+|.++...|++.|++-+++|+|+||+|||++|+++|.+++||.+++++|+|++|+.+.|...++|+.+++ T Consensus 243 ~ply~~l~ayvr~kl~~~yg~~i~~~~~iPahllg~~~~~~w~~~y~~~~p~~~~~~~dv~~~~~~~~~t~~~~~~~a~~ 322 (814) T 6M18_B 243 KPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEK 322 (814) T ss_dssp HHHHHHHHHHHHHHHTTTSTTSSCTTBCEEGGGSSSSSSSCCGGGHHHHCSSTTSCCCCCTTHHHHTTCCTTHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHCcccCCCCCCCcHHHhHhhhHHHHHHhhcccCCCCCCCCCCCcHHHHhcCCCHHHHHHHHHH Confidence 99999999999999999888777888999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 314 FFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLR 393 (805) Q Consensus 314 ffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllr 393 (805) ||.++|++.|+++||++++++.|+.-..++|||++||.+.+|+||+||++++|+||+|.||||||++|.|.|..||++.| T Consensus 323 ~f~~lgl~~~~~~fw~~s~~~r~~K~~~~~C~~~a~d~~~~d~rI~~~~~~~~~d~~tl~HE~GHa~h~~~~~~qp~~~~ 402 (814) T 6M18_B 323 FFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLR 402 (814) T ss_dssp HHHHTTCCCCCSSTTTSCBCSCCCSSCCCCCSCEEEECSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHTTSTTSCGGGC T ss_pred HHHhcCCCCCCCCcccHHhccCCCCCCCCCcCchHhcCCCCCeEEEeecCCCHHHHHHHHHHHHHHHHHHHhccCCchhc Confidence 99999999999999999999999988899999999999889999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 394 NGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQW 473 (805) Q Consensus 394 nganegfheavgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqw 473 (805) .|++.+||||++++|++++.+|+||+++|++.++++++.+.+||+|++++|++++++||.+++++|||.+|.|++++++| T Consensus 403 ~~a~~~f~Eavsel~el~~~~p~~L~~~~ll~~~~~~~~~~~in~ll~~aL~~l~~lp~~~~~d~~r~~~f~g~i~~~~l 482 (814) T 6M18_B 403 NGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQW 482 (814) T ss_dssp SCSSTTSHHHHHHHHHHHSSSHHHHHHHTCSCSSCCCCTTHHHHHHHHHHHHTTTTHHHHHHHHHHHHHHHHTSSCGGGH T ss_pred cCCChHHHHHHHHHHHHHhhCHHHHHHccCcCCCCCCCcHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHhcCCCCHHHH Confidence 99999999999999999999999999999999988888899999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 474 MKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQK 553 (805) Q Consensus 474 mkkwwemkreivgvvepvphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqk 553 (805) ++.||++.++..|++.|+++++++|||++.+|+.+++.+++|++.++++||+.+++|+.+.|+||||+||+++++++|++ T Consensus 483 n~~w~el~~~y~Gv~~p~~~~~~~~d~~~~~Hi~~~~~Yy~Y~~s~i~a~qi~~~l~~~~~~~~pl~~c~~~~s~~ag~~ 562 (814) T 6M18_B 483 MKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQK 562 (814) T ss_dssp HHHHHHHCCCCCCEECSSCCCTTCCGGGGSHHHHTTCCCTHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCTTHHHH T ss_pred HHHHHHHHHHHcCCCCCCCCCccCCCHHHHhhhhcCcchHHHHHHHHHHHHHHHHHHHHcccCCCchhCCCCCCHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 554 LFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAY 633 (805) Q Consensus 554 lfnmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyadqsikvrislksalgdkay 633 (805) |.+||+.|.|.||+-+++.+.|...+++.|+++||+||.+||+.+|++..+||.++|+||.+++||||||||+||||+|| T Consensus 563 l~~lL~~G~S~~~~ell~~~~G~~~~s~~~ll~yf~pL~~wL~~~n~~~~~gw~~~~~~~~~~~~~~~~~~~~~~~~~~~ 642 (814) T 6M18_B 563 LFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAY 642 (814) T ss_dssp HHHHHTTTTSSCHHHHHHTTTSCSSCCSHHHHHHTHHHHHHHHHHTSSSCCSCBTTCCTTSSSCEEEEECHHHHTSSSCC T ss_pred HHHHHhcCCCCCHHHHHHHHHCCCCCCcHHHHHhHHHHHHHHHHhccCCCCCCCCCCCCCCCCcceeEEEcchhcCcccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 634 EWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRIND 713 (805) Q Consensus 634 ewndnemylfrssvayamrqyflkvknqmilfgeedvrvanlkprisfnffvtapknvsdiiprtevekairmsrsrind 713 (805) +||+||||||||++|||||+||.++|+|.+.|..+||.|.|.+|||||.|+||.|.|+|++||+.|||+||||||.|||+ T Consensus 643 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 722 (814) T 6M18_B 643 EWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRIND 722 (814) T ss_dssp CCCHHHHHHHHHHHHHHHHHHHHHTSCCCCCCCGGGEEEECCCTTSEEEEEEEETTEEEEECCHHHHHHHHHHTHHHHHH T ss_pred cCChhhHHHHHHHHHHHHHHHHHHHccceeecccccEEEecCCCcEEEEEEEecCCCccccCCHHHHHHHHHhchhhhhh Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 714 AFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNP 793 (805) Q Consensus 714 afrlndnsleflgiqptlgppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkknkarsgenpyasidiskgennp 793 (805) ||+|+|++|||+||+|||+||.+|||.|||||||||||++||||++||++|||+||||+|+++++|||+++|+++|++|| T Consensus 723 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 802 (814) T 6M18_B 723 AFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNP 802 (814) T ss_dssp HHTCCSSSEECSSCCCCCCCCCCCSSCTHHHHHHHHHHHHHHHHHHHHTTTTTTC------------------------- T ss_pred hhhcCCCceeecccCCCCCCCCCCCcchHHHHHHHHHHHHHHHHHHHHHhChhhHHHHccccCCCCCCccccccCCccCc Confidence 99999999999999999999999999999999999999999999999999999999999999899999999999999999 Q sp|Q9BYF1|ACE2 794 GFQNTDDVQTSF 805 (805) Q Consensus 794 gfqntddvqtsf 805 (805) |||++||+|||| T Consensus 803 ~~~~~~~~~~~~ 814 (814) T 6M18_B 803 GFQNTDDVQTSF 814 (814) T ss_dssp ------------ T ss_pred ccCCCcccccCC Confidence 999999999998 No 2 >1R42_A angiotensin I converting enzyme 2; zinc metallopeptidase domain, collectrin homology; HET: NAG; 2.2A {Homo sapiens} SCOP: d.92.1.5 Probab=100.00 E-value=3.4e-78 Score=581.98 Aligned_cols=615 Identities=100% Similarity=1.557 Sum_probs=553.7 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 1 MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLA 80 (805) Q Consensus 1 msssswlllslvavtaaqstieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstla 80 (805) |++++|+|++||+++++.+..++.+.+++++++.+...+....+++.|.+.++.+++..+....+..+.+.++.+..+.. T Consensus 1 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~ 80 (615) T 1R42_A 1 MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLA 80 (615) T ss_dssp ------------------CCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHTTT T ss_pred ChhHHHHHHHHHHHHhcCCCcHHHHHHHHHHHHHHHHHHHhHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 78999999999999999999999999999999999999999999999999999999999988889999999999999988 Q sp|Q9BYF1|ACE2 81 QMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNE 160 (805) Q Consensus 81 qmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldyne 160 (805) ..|.+..+.+-..+-+|+.+...+...|+++..++++..++.|...|++..+|.++.|.+|+.+.|.+..+|+++-|... T Consensus 81 ~~~~~~~~~~~~~~~~l~~~~~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~l~~~~d~~~ 160 (615) T 1R42_A 81 QMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNE 160 (615) T ss_dssp TTSCSTTCCCHHHHHHHHHHTCCGGGGSCHHHHHHHHHHHHHHHHHHHHCEEEETTEEEEEEETTTBHHHHHHHCCCHHH T ss_pred hhCChhhcCCHHHHHHHHHHHhcCccCCCHHHHHHHHHHHHHHHHHHhcCCccCCCCCCcccccChhHHHHHhcCCCHHH Confidence 88887766666777788877777777888888888889999999999999999888888899888999999999999999 Q sp|Q9BYF1|ACE2 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHL 240 (805) Q Consensus 161 rlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehl 240 (805) |-.+|++|+...++.+.+++.+.+-+++++|+...|++|.|||..++++++++++||+..++.+.++..++.++|+|+.+ T Consensus 161 R~~~~~~~~~~~~~~~~~~l~~lv~lr~~~A~~~Gy~~~~~~~l~~~~~~~~~~~~y~~~~~~~~l~~l~~~v~p~~~~~ 240 (615) T 1R42_A 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHL 240 (615) T ss_dssp HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTTCBCSCTTTCBCSHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhHHhHHHHHHHHHHHHHHHHHCCCCCHHHHHHHhhccCCCCCCCCChhHHHHHHHHHHHHHHHHHHHH Confidence 99999999998889999999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 241 HAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGL 320 (805) Q Consensus 241 hayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvgl 320 (805) |+|+|.++...|+.-+++-+..|+|++|.||+..|+.+|....|+.+.+..+++..++.+.|..+++++.++++|-++|+ T Consensus 241 ~~~~~~~~~~~~~~~~~~~~l~p~d~~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~ 320 (615) T 1R42_A 241 HAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGL 320 (615) T ss_dssp HHHHHHHHHHHSTTTSCTTBCEEGGGSSSSSCSCCGGGHHHHCTTTTSCCCCCTTTTGGGTCCHHHHHHHHHHHHHTTTC T ss_pred HHHHHHHHHHHCccCCCCCCCccHHHccccchhcchhhHhccCCCCCCCCCCCcHHHHHCCCCHHHHHHHHHHHHHHcCC Confidence 99999987766664445567889999999999999999999999999988999999999999999999999999999999 Q sp|Q9BYF1|ACE2 321 PNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGF 400 (805) Q Consensus 321 pnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegf 400 (805) ..++..+|.++++..+|....+.|+|.+|+.+.++.||++|...+.+|+.|.+||+||..|.+.+..||++.+.+++.+| T Consensus 321 ~~~~~~~w~~~~~~r~~K~~~~~c~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~ 400 (615) T 1R42_A 321 PNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGF 400 (615) T ss_dssp CCCCTTHHHHCBCSCCCTTCCCCCSCEEEEEETTEEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSTTH T ss_pred ccCCcchhhhhccCCCCCCCCCccccchhcCCCCceEEEecCCCCHHHHHHHHHHHHHHHHHHHhccCCchHcCCCChHH Confidence 99999999999998888877899999999887789999999999999999999999999999999899999998899999 Q sp|Q9BYF1|ACE2 401 HEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM 480 (805) Q Consensus 401 heavgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwem 480 (805) +|+++++|+..+.+|.+|+.++++....+...+.+++.++++++..+..+|+.++++.|+|.+|.|+++.+++-+.||+. T Consensus 401 ~E~~s~~~e~~~~~~~~l~~~~~~~~~~~~~~~~~~~~l~~~~l~~~~~l~~~~~~d~~~~~~~~~~~~~~~~~~~~~~l 480 (615) T 1R42_A 401 HEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM 480 (615) T ss_dssp HHHHHHHHHHHHHSHHHHHHTTSSCTTSCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHTCSCGGGHHHHHHHH T ss_pred HHHHHHHHHHHhcCHHHHHHcCCCCcccCCCcHHHHHHHHHHHHHHHhhccHHHHHHHHHHHHHcCCCCHHHHHHHHHHH Confidence 99999999999999999999999876655555668889999999999999999999999999999999889999999999 Q sp|Q9BYF1|ACE2 481 KREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRL 560 (805) Q Consensus 481 kreivgvvepvphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrl 560 (805) .++..|+..|++.++...++++..|...+..++.|....+..+|+-+++|+...++||||.|++.++.++|+++.++|+. T Consensus 481 ~~~y~g~~~~~~~~~~~~~~~~~~H~~~~~~Yy~Y~~s~~~a~ql~~~~~~~~~~~~~l~~~~~~~~~~~g~~~~~~l~~ 560 (615) T 1R42_A 481 KREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRL 560 (615) T ss_dssp CCCCCCEECSSCCCTTCCGGGGSHHHHTTCCCTHHHHHHHHHHHHHHHHHHTTTCCSCGGGCCCTTCHHHHHHHHHHHTT T ss_pred HHHHcCCCCCCCCCcccCChhHcccccCChhHHHHHHHHHHHHHHHHHHHHHhccCCChhhcCcCCChHHHHHHHHHHhc Confidence 99999988777777788899988898766666888899999999999999988889999999999999999999999999 Q sp|Q9BYF1|ACE2 561 GKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 615 (805) Q Consensus 561 gksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyad 615 (805) |.+.||.-.++.+.|....+..+++.+|+||.+||+.+|++..+||.++|+|++| T Consensus 561 G~s~~~~ell~~~~g~d~~s~~~~~~~~~~l~~~l~~~~~~~~~gw~~~~~~~~~ 615 (615) T 1R42_A 561 GKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 615 (615) T ss_dssp TTSSCHHHHHHHHHSSSSCCSHHHHHHHHHHHHHHHHHTSSSCCSCBSSCCTTCC T ss_pred CCCCCHHHHHHHHHCCCCCChHHHHHhHHHHHHHHHHHhcCCCCCCCCCCCCcCC Confidence 9999999999999999889999999999999999999999999999999999985 No 3 >6LZG_A Angiotensin-converting enzyme 2 (E.C.3.4.17.23), Spike; Novel Coronavirus, Spike protein, receptor; HET: NAG; 2.5A {Homo sapiens} Probab=100.00 E-value=5.4e-74 Score=545.88 Aligned_cols=597 Identities=100% Similarity=1.567 Sum_probs=545.8 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 19 STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQ 98 (805) Q Consensus 19 stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlq 98 (805) ||.++.+..+++.++.....+-...+++.|.++++.+++..+..+.+..+.+.+..+.+.....+.+..+.+-..+-+|+ T Consensus 1 ~~~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~ 80 (597) T 6LZG_A 1 STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQ 80 (597) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHHHHTTSCGGGCCCHHHHHHHH T ss_pred CChHHHHHHHHHHHHHHHHHHHhHHHhHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHhcCChhhcCCHHHHHHHH Confidence 35567788999999999999999999999999999999988888888899999998888877777766666666777788 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRP 178 (805) Q Consensus 99 alqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrp 178 (805) .+...+...|+++..++++.+++.+..+|++...|.+++|.+|+.+.+.+..+|+++-|...|.-+|++|++..++.+.+ T Consensus 81 ~~~~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~ 160 (597) T 6LZG_A 81 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRP 160 (597) T ss_dssp HHHCCGGGGSCHHHHHHHHHHHHHHHHHHHHCEEECTTCTTCEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCCCHHHHH T ss_pred HHHhcCccCCCHHHHHHHHHHHHHHHHHHhcCCccCCCCCCceeccCccHHHHHhcCCCHHHHHHHHHHHHHHhcHHhHH Confidence 77777778889988888889999999999999999998889999999999999999999999999999999988889999 Q sp|Q9BYF1|ACE2 179 LYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISP 258 (805) Q Consensus 179 lyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp 258 (805) ++.+.|.+++++|+.+.|++|.|||...+++++++++||+..++.+-++..++.|+|+|+.+|+|+|.++...|..-+++ T Consensus 161 ~l~~lv~~r~~~A~~~Gy~~~~~~~l~~~~~~~~~~~~~~~~~~~~~l~~l~~~v~p~~~~~~~~~~~~~~~~~~~~~~~ 240 (597) T 6LZG_A 161 LYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISP 240 (597) T ss_dssp HHHHHHHHHHHHHHHTTCSSHHHHHHGGGCBCSCTTTCBCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSTTTCCS T ss_pred HHHHHHHHHHHHHHHCCCCCHHHHHHHhhccCCCCCCCCchhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCccCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999877766543445 Q sp|Q9BYF1|ACE2 259 IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGN 338 (805) Q Consensus 259 igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgn 338 (805) -+..|+|++|.+|+..|+++|....|+.+.+..++++.+..+.+..+++++.++++|-++|+..+...+|+++.+..++. T Consensus 241 ~~~~p~d~~~~~~~~~~~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~w~~~~~~r~~k 320 (597) T 6LZG_A 241 IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGN 320 (597) T ss_dssp SSCEETTSSSSSSCSCCGGGHHHHCSCTTSCCCCCHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCCS T ss_pred CCCCcHHHcccchhhhhhhhHhccCCCCCCCCCCCcHHHHHcCCCHHHHHHHHHHHHHHcCCccCCcchhhhhccCCCCC Confidence 57899999999999999999999999999888889998888899999999999999999999999999999998888888 Q sp|Q9BYF1|ACE2 339 VQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHL 418 (805) Q Consensus 339 vqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhl 418 (805) ...+.|+|.+|+...++.||++|...+.+|+.+.+||+||..|.+.+..||++++.+++.+|+|+++++|+..+.+|.+| T Consensus 321 ~~~~~c~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HElGHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~~L 400 (597) T 6LZG_A 321 VQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHL 400 (597) T ss_dssp SSCCCCSCEEEEEETTEEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSTTHHHHHHHHHHHHHHSHHHH T ss_pred CCCCccCccHhcCCCCcEEEEecCCCCHHHHHHHHHHHHHHHHHHHhccCCchhcCCCChHHHHHHHHHHHHHhcCHHHH Confidence 78899999999876689999999999999999999999999999999999999988889999999999999999999999 Q sp|Q9BYF1|ACE2 419 KSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYC 498 (805) Q Consensus 419 ksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc 498 (805) +.++++....+.+.+..++.++.+++..+..+|+..+++.|+|-+|.|+++.+.+.+.||+...+..|++.|++.++... T Consensus 401 ~~~~l~~~~~~~~~~~~~~~l~~~~l~~~~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~~~~~y~g~~~~~~~~~~~~ 480 (597) T 6LZG_A 401 KSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYC 480 (597) T ss_dssp HHTTSSCTTCCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHTCSCGGGHHHHHHHHCCCCCCEECSSCCCTTCC T ss_pred HHcCCCCcccCCChHHHHHHHHHHHHHHHhhchhHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCCcccC Confidence 99998876554455667888999999999999999999999999999999999999999999999999988776667778 Q sp|Q9BYF1|ACE2 499 DPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKN 578 (805) Q Consensus 499 dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvgakn 578 (805) ++++..|+..+..+..|....+..+|+.+.+|+...++||+|.|++.++.++|+++.++|+.|.+.+|.-.++.+.|... T Consensus 481 ~~~~~~H~~~~~~Yy~Y~~~~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~G~s~~~~ell~~~~g~~~ 560 (597) T 6LZG_A 481 DPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKN 560 (597) T ss_dssp GGGGSHHHHTTCCCTHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHHHHSCSS T ss_pred ChhHccccccChhHHHHHHHHHHHHHHHHHHHHHhccCCChhhCCcCCCHHHHHHHHHHHhcCCCCCHHHHHHHHHCCCC Confidence 88888887655555888899999999999999988889999999999999999999999999999999999999999988 Q sp|Q9BYF1|ACE2 579 MNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 615 (805) Q Consensus 579 mnvrpllnyfeplftwlkdqnknsfvgwstdwspyad 615 (805) .+..++++||+||..||+.+|++..+||.++|.|++| T Consensus 561 ~~~~~l~~~~~~l~~~l~~~~~~~~~gw~~~~~~~~~ 597 (597) T 6LZG_A 561 MNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 597 (597) T ss_dssp CCSHHHHHHHHHHHHHHHHHGGGSCCSCCSSCCTTC- T ss_pred CCcHHHHHhHHHHHHHHHHhhcCCCCCCCCCCCCCCC Confidence 8899999999999999999999999999999999985 No 4 >3D0I_B Crystal structure of spike protein; SARS coronavirus, spike protein, receptor-binding; HET: NAG, NDG; 2.9A {Paguma larvata} Probab=100.00 E-value=1.2e-73 Score=545.19 Aligned_cols=596 Identities=98% Similarity=1.548 Sum_probs=544.0 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 20 TIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQA 99 (805) Q Consensus 20 tieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqa 99 (805) |-++.++.|+++++.....+-...+.+.|.++++.+++..+....+-.+.+.+.++.......|.+..+.+-..+-+|+. T Consensus 2 ~~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~ 81 (597) T 3D0I_B 2 TTEELAKTFLETFNYEAQELSYQSSVASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQA 81 (597) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCCHHHHHHHHHHHHHHHHHHHHHHHHHHTSCGGGCCCHHHHHHHHH T ss_pred ccHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHHHHHHHHHhhCChhhcCCHHHHHHHHH Confidence 33567788999999999999999999999999999999888888888899999888887777777666666667778888 Q sp|Q9BYF1|ACE2 100 LQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL 179 (805) Q Consensus 100 lqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrpl 179 (805) +...+...|+++...+++.+.+.+..+|++..+|.+++|.+|+.+.+.+..+|.++-|...|..+|++|+...+..+.+. T Consensus 82 l~~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~ 161 (597) T 3D0I_B 82 LQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL 161 (597) T ss_dssp HSCCTGGGSCHHHHHHHHHHHHHHHHHHHHCEEEETTEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHTHHHHHHHH T ss_pred HHhcCccCCCHHHHHHHHHHHHHHHHHHhcCCccCCCCCCcccccCccHHHHHhcCCCHHHHHHHHHHHHHHhcHHhHHH Confidence 88888888999888888899999999999999998888888998888999999999999999999999998888899999 Q sp|Q9BYF1|ACE2 180 YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPI 259 (805) Q Consensus 180 yeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispi 259 (805) +.+.+.+++++|+.+.|++|.+||-.++++++.+++||+..++.+-++..++.|+|+|+.+|+|+|.++...|..-+++- T Consensus 162 l~~lv~lr~~~A~~~Gy~~~~~~~l~~~~~~~~~~~~~~~~~~~~~l~~l~~~i~p~~~~~~~~~~~~~~~~~~~~~~~~ 241 (597) T 3D0I_B 162 YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPI 241 (597) T ss_dssp HHHHHHHHHHHHHHTTCSSHHHHHHGGGCBCSSSSSCBCHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHSTTSCCTT T ss_pred HHHHHHHHHHHHHHCCCCCHHHHHHHhcccCCCCCCCCChhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCcccCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999998776664334455 Q sp|Q9BYF1|ACE2 260 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339 (805) Q Consensus 260 gclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnv 339 (805) ...|+|++|+||+.-|+.+|....|+.+.+..+++..++.+.+...++++.++++|-++|+..+...||+++....++.. T Consensus 242 ~~~p~~~~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~w~~~~~~r~~K~ 321 (597) T 3D0I_B 242 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 321 (597) T ss_dssp BCEEGGGSSSSSCSCCGGGGGGTCSCTTSCCSCTHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCCSS T ss_pred CCccHHHccccchhhchhhHhhcCCCCCCCCCCCcHHHHHcCCCHHHHHHHHHHHHHHcCCccCCcchHhhhccCCCCCC Confidence 78999999999999999999999999998888999999888899999999999999999999999899999998888888 Q sp|Q9BYF1|ACE2 340 QKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK 419 (805) Q Consensus 340 qkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlk 419 (805) ..+.|+|.+|++..++.||++|...+++|+.|.+||+||+.+.+.+..||++.+..++.+|.|+++++|+..+.+|.+|+ T Consensus 322 ~g~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~l~e~~~~~~~~L~ 401 (597) T 3D0I_B 322 QKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK 401 (597) T ss_dssp SCCCCSCEEEEEETTEEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSTTHHHHHHHHHHHHHHSHHHHH T ss_pred CCCccCccHhhcCCCcEEEEecCCCCHHHHHHHHHHHHHHHHHHHhccCChhHcCCCChHHHHHHHHHHHHHhcCHHHHH Confidence 88999999999877899999999999999999999999999999998999999888899999999999999999999999 Q sp|Q9BYF1|ACE2 420 SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 499 (805) Q Consensus 420 sigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycd 499 (805) .++++........+..++.++.+++..+..+|+.++++.|+|.+|.|+++.+.+.+.||+..++..|+..|++.++...+ T Consensus 402 ~~~~~~~~~~~~~~~~~~~l~~~~l~~l~~l~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~y~g~~~~~~~~~~~~~ 481 (597) T 3D0I_B 402 SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 481 (597) T ss_dssp HHTSSCSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCSCTTTTTHHHHHHHHHTSCEECSSCCCTTCCC T ss_pred HcCCCCcccCCChHHHHHHHHHHHHHHHhcchHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCCcccCC Confidence 99988765444455677889999999999999999999999999999998899999999999999998887776667778 Q sp|Q9BYF1|ACE2 500 PASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNM 579 (805) Q Consensus 500 paslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvgaknm 579 (805) +++..|+..+..++.|....+..+|+.+.+|+...+.||+|.||+..+.++|+++.++|+.|.+.+|.-.++...|.... T Consensus 482 ~~~~~H~~~~~~Yy~Y~~s~~~a~~i~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~l~~G~s~~~~ell~~~~g~d~~ 561 (597) T 3D0I_B 482 PASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNM 561 (597) T ss_dssp GGGSHHHHTTCCCTHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHHHHSCSSC T ss_pred hhHccccccChhHHHHHHHHHHHHHHHHHHHHHhcccCChhhcCcCCCHHHHHHHHHHHhcCCCCCHHHHHHHHHCCCCC Confidence 88888887655558888899999999999999888899999999999999999999999999999999999999999888 Q sp|Q9BYF1|ACE2 580 NVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 615 (805) Q Consensus 580 nvrpllnyfeplftwlkdqnknsfvgwstdwspyad 615 (805) ++.+++.+|+||..||+.+|++..+||.++|.|++| T Consensus 562 ~~~~~~~~~~~l~~~l~~~~~~~~~gw~~~~~~~~~ 597 (597) T 3D0I_B 562 NVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD 597 (597) T ss_dssp CSHHHHHHHHHHHHHHHHHGGGSCCSCBTTCCSSCC T ss_pred CcHHHHHhHHHHHHHHHHhhcCCCCCCCCCCCCCCC Confidence 899999999999999999999999999999999985 No 5 >5AMB_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1), AMYLOID BETA; HYDROLASE, ANGIOTENSIN-CONVERTING ENZYME, METALLOPROTEASE, AMYLOID-BETA; HET: P6G, PG4, FUC, NAG, PEG, BMA; 1.55A {HOMO SAPIENS} Probab=100.00 E-value=1.2e-69 Score=524.17 Aligned_cols=595 Identities=42% Similarity=0.814 Sum_probs=518.7 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 20 TIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP---LQEIQNLTVKLQ 96 (805) Q Consensus 20 tieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp---lqeiqnltvklq 96 (805) .-++.+.+||+.++.+...+-...+++.|.++++.+.+..+....+..+.+.+..+.++.+.... ++.+..-..+-+ T Consensus 12 ~~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~ 91 (629) T 5AMB_A 12 ADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRI 91 (629) T ss_dssp SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTGGGCSCHHHHHH T ss_pred CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhhccHHHhcCCHHHHHH Confidence 34577889999999999999999999999999999999888888888888888887766433211 122233345556 Q sp|Q9BYF1|ACE2 97 LQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQL 176 (805) Q Consensus 97 lqalqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkql 176 (805) |+.+...+...|+++..+++..+.+.|+.+|++...|.++.+..|+.+.+.+..+|+++-|...|.-+|+.|+...+..+ T Consensus 92 l~~l~~~~~~~L~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~ 171 (629) T 5AMB_A 92 IGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLPQKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPL 171 (629) T ss_dssp HHHHTCCGGGGSCHHHHHHHHHHHHHHHHHHHHCEEEC---CCCEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHhcccCCCHHHHHHHHHHHHHHHHHHhhccccCCCCCCceeecChhHHHHHHhCCCHHHHHHHHHHHHHHhCccc Confidence 66666666677888887888889999999999999998777778888888999999999999999999999999888999 Q sp|Q9BYF1|ACE2 177 RPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-Y 255 (805) Q Consensus 177 rplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-y 255 (805) ++++.+.|-+++++|+...|++|.+||..+|+. +...+.++..++.|+|+|+.+|+|+|.++...|.. . T Consensus 172 ~~~l~~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~~~~~l~~l~~~i~~~~~~~~~~~~~~~~~~~g~~~ 241 (629) T 5AMB_A 172 KPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNS----------PTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRY 241 (629) T ss_dssp HHHHHHHHHHHHHHHHTTTCSSHHHHHHHTTCC----------TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTT T ss_pred HHHHHHHHHHHHHHHHHcCCCCHHHHHHHhhCC----------ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccc Confidence 999999999999999999999999999887642 34556677888999999999999999987665542 2 Q sp|Q9BYF1|ACE2 256 ISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTD 335 (805) Q Consensus 256 ispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltd 335 (805) +++-+.+|+|++|++|+..|+++|.+++|+.+....+|++.++.+.+....+++.++++|.++|++.++..||++++... T Consensus 242 ~~~~~~ip~dll~~~~~~~~~~~~~~~~p~~~~~~~~v~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~~~~~~~~~ 321 (629) T 5AMB_A 242 INLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEK 321 (629) T ss_dssp CCTTSCEETTSSSSTTSCCCGGGHHHHCSCTTSCCCCTHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSC T ss_pred cCCCCCCCHHHccChhhhhhhhhhcccccCCCCCCCCCcHHHHhcCCCHHHHHHHHHHHHHhCCCCCCChhHhhcccccC Confidence 33445679999999999999999999999988888889999999888899999999999999999999999999999888 Q sp|Q9BYF1|ACE2 336 PGNVQKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAAT 414 (805) Q Consensus 336 pgnvqkavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaat 414 (805) |+.....+|||.+|++.. ++.||++|...+++|+.|.+|||||..|.+.+..||++.+.+++.+|||+++++|+..+.+ T Consensus 322 ~~k~~~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~ 401 (629) T 5AMB_A 322 PADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVST 401 (629) T ss_dssp CTTCCCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHHTTSCGGGCSCSSHHHHHHHHHHHHHHHTS T ss_pred CCCCCccccccchhhccCCCCeEEEecCCCCHHHHHHHHHHHHHHHHHHHcCCCCHHHcCCCCHHHHHHHHHHHHHHhcC Confidence 887777899999999985 7899999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 415 PKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHD 494 (805) Q Consensus 415 pkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphd 494 (805) |.+|+.++++... +...+..++.++++++..+..+|+.++++.|+|.+|.|+++.+++.+.||+..++..|+..|.+.+ T Consensus 402 ~~~L~~~~~~~~~-~~~~~~~~~~l~~~~l~~~~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~~~~~y~g~~~~~~~~ 480 (629) T 5AMB_A 402 PEHLHKIGLLDRV-TNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRN 480 (629) T ss_dssp HHHHHHTTSCCCC-CCSHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHTSSCGGGHHHHHHHHCCCCCCEECSSCCC T ss_pred HHHHHHcCCCCCC-CCCcHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHhhCCCCChhhHHHHHHHHHHHhCCCCCCCCCC Confidence 9999999987543 223345678899999999999999999999999999999999999999999999999987766667 Q sp|Q9BYF1|ACE2 495 ETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVV 574 (805) Q Consensus 495 etycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvv 574 (805) +...||++..|+..+..++.|....+.++|+-+.+|+...++||||+||+..+.++|+++.++|+.|.+.+|.-.++.+. T Consensus 481 ~~~~~~~~~~H~~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~pl~~~~~~~~~~~g~~~~~~L~~G~s~~~~ell~~~~ 560 (629) T 5AMB_A 481 ETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMV 560 (629) T ss_dssp TTCCGGGGSTTTTTTCCCHHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHHHTTSSCHHHHHHHHH T ss_pred cccCCcCcccccCCChhHHHHHHHHHHHHHHHHHHHHHcCCCCCcccCCccCCHHHHHHHHHHHhcCCCCcHHHHHHHHh Confidence 78889999999876556889999999999999999998889999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 575 GAKNMNVRPLLNYFEPLFTWLKDQNK--NSFVGWST-DWSPYADQSIKVRISLK 625 (805) Q Consensus 575 gaknmnvrpllnyfeplftwlkdqnk--nsfvgwst-dwspyadqsikvrislk 625 (805) |....+..+++.+|+||..||+.+|+ +.-+||.. +|.|++..+++++|++- T Consensus 561 G~d~~~~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~~~~~~~~~~~~~~~~~ 614 (629) T 5AMB_A 561 GLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLV 614 (629) T ss_dssp SCSSCCSHHHHHHHHHHHHHHHHHHHHHTCCSSCSCTTCCCCCCTTCSCC---- T ss_pred CCCCCChHHHHHHHHHHHHHHHHHHHhcCcccCCcccCCCCCCCCCCCCCCCCC Confidence 99889999999999999999999999 56699996 99999999999999983 No 6 >6H5W_A Angiotensin-converting enzyme (E.C.3.2.1.-,3.4.15.1); Angiotensin-1 converting enzyme, ACE inhibitor; HET: BO3, CSO, FUC, FT8, P6G, EDO, BMA, IMD, NAG; 1.37A {Homo sapiens} Probab=100.00 E-value=4.4e-61 Score=455.72 Aligned_cols=579 Identities=43% Similarity=0.858 Sum_probs=503.4 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) +..+..||+.++.....+-...+++.|.++++++++.++....+-.+.+.+..+..+.+..|..+.+.+-.++-.++.+. T Consensus 5 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 84 (591) T 6H5W_A 5 EAEASKFVEEYDRTSQVVWNEYAGANWNYNTNITTETSKILLQKNMQIAQHTLKYGTQARKFDVNQLQNTTIKRIIKKVQ 84 (591) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTSCCHHHHHHHHHHHHHHHHHHHHHHHHHTTSCGGGCCCHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHhhHHHHHHcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcCcccCCCHHHHHHHHHHH Confidence 55678899999999999999999999999999999999999989999999999888877766645555555666666666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYE 181 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrplye 181 (805) ..+...|+++....+..+...+..+|++.++|.++ .+|+.+.+.+..+|+++-|...|.-+|+.|+...+..++|.+. T Consensus 85 ~~~~~~L~~~~~~~~~~l~~~~~~~~~~~~~~~~~--g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~l~ 162 (591) T 6H5W_A 85 DLERAALPAQELEEYNKILLDMETTYSVATVCHPQ--GSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYP 162 (591) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCEEECTT--SCEEECCCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHTTTHH T ss_pred hhhhccCCHHHHHHHHHHHHHHHhhhccceecCCC--CceecCChhHHHHHhhCCCHHHHHHHHHHHHHHhhHHhHHHHH Confidence 66666778876667777788888999999999874 4677788899999999999999999999999887889999999 Q sp|Q9BYF1|ACE2 182 EYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPIG 260 (805) Q Consensus 182 eyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispig 260 (805) +.+-+++++|+...|++|.+||..+|+. +.+.+.++..++.++|+|+.+|+|+|.|+...+.. -+++-+ T Consensus 163 ~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~v~~~l~~l~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~ 232 (591) T 6H5W_A 163 KYVELINQAARLNGYVDAGDSWRSMYET----------PSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEG 232 (591) T ss_dssp HHHHHHHHHHHHTTCSSHHHHHHHTTCC----------TTHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHCGGGCCTTS T ss_pred HHHHHHHHHHHHCCCCCHHHHHHhccCC----------ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccCCCCC Confidence 9999999999999999999999887732 34557788889999999999999999987544432 244557 Q sp|Q9BYF1|ACE2 261 CLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQ 340 (805) Q Consensus 261 clpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvq 340 (805) -+|+|++|.+|+.-|+++|.++.|+...+..++++++..+.+...++++.++++|.+.|+..|..+||+++....|+... T Consensus 233 ~~p~~~~~~~~~~~~~~~~~~~~p~~~~~~~~v~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~~~~~~~~~~~k~~ 312 (591) T 6H5W_A 233 PIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWQKSMLEKPTDGR 312 (591) T ss_dssp CEETTSSSSTTSSCCGGGHHHHCSCTTSCCCCHHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSSSC T ss_pred CCcHHHchhhhhHhhHhhhhccCCCCCCCCCCcHHHHHHCCCCHHHHHHHHHHHHHhCCCCCCChHHHhhccccCCCCCC Confidence 88999999999999999999999998888888888877777888999999999999999988889999998877777655 Q sp|Q9BYF1|ACE2 341 KAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK 419 (805) Q Consensus 341 kavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlk 419 (805) ..+|||.++++.. ++.||++|...+.+++.|.+||+||..|.+.+..||++++.++.-+|+|+++++|+..+.+|.+|+ T Consensus 313 ~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~~l~ 392 (591) T 6H5W_A 313 EVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLH 392 (591) T ss_dssp CCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHHHH T ss_pred cceecceeeeCcCCCceEEEecCCCCHHHHHHHHHHHHHHHHHHHhcCCCHHHccCCChHHHHHHHHHHHHHhcCHHHHH Confidence 6799999999875 689999999999999999999999999999999999999888999999999999999999999999 Q sp|Q9BYF1|ACE2 420 SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 499 (805) Q Consensus 420 sigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycd 499 (805) .++++... ..+.+..++.++.+++..+..+|+.++++.|+|-++.|.++.+++-+.||+...+..|+..|.+......| T Consensus 393 ~~~~~~~~-~~~~~~~~~~l~~~~~~~~~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~~~~~y~g~~~~~~~~~~~~~ 471 (591) T 6H5W_A 393 SLNLLSSE-GGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFD 471 (591) T ss_dssp HTTSSCCC-CSCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTSSCTTTHHHHHHHHCCCCCCEECSSCCCTTCCG T ss_pred hcCCCCCC-CCChHHHHHHHHHHHHHHhhcchHHHHHHHHHHHHhCCCCCHHhHHHHHHHHHHHHcCCCCCCCCCcccCC Confidence 99987653 23334467788899999999999999999999999999888889999999999999898766555566778 Q sp|Q9BYF1|ACE2 500 PASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNM 579 (805) Q Consensus 500 paslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvgaknm 579 (805) |++..|......+..|....+..+|+.+.+|+...|+||+|.|++..+.++|+++-++|+.|.+.+|.-.++...|..-. T Consensus 472 ~~~~~H~~~~~y~y~Y~~~~~~a~ql~~~~~~~~~~~~~l~~~~~~~~~~~g~~~~~~l~~G~s~~~~ell~~~~g~d~~ 551 (591) T 6H5W_A 472 PGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPQM 551 (591) T ss_dssp GGGSTTTTTTCCSHHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHHHHSSCSC T ss_pred CcccccCCCCchhHHHHHHHHHHHHHHHHHHHHcCCCCCcccCCccCCHHHHHHHHHHHHcCCCCCHHHHHHHHHCCCCC Confidence 88888888666778888888999999999999888899999999998899999999999999999999999999998878 Q sp|Q9BYF1|ACE2 580 NVRPLLNYFEPLFTWLKDQNKN--SFVGWST-DWSPY 613 (805) Q Consensus 580 nvrpllnyfeplftwlkdqnkn--sfvgwst-dwspy 613 (805) +..+++.+|+|+..||+.+|+. --+||.. .|.|- T Consensus 552 ~~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~~~~~ 588 (591) T 6H5W_A 552 SASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPN 588 (591) T ss_dssp CSHHHHHHHHHHHHHHHHHHHHHTCCCSCSSTTCCCC T ss_pred ChHHHHHhHHHHHHHHHHHHHhhCCccCCCccCCCCC Confidence 8999999999999999999875 4599987 67664 No 7 >6S1Y_A Angiotensin-converting enzyme (E.C.3.4.-.-); metalloprotease, mosquito control, insecticide design; HET: PEG, EDO, NAG, BMA, KSN; 2.2A {Anopheles gambiae} Probab=100.00 E-value=4.6e-59 Score=450.26 Aligned_cols=579 Identities=37% Similarity=0.727 Sum_probs=484.7 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 21 IEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQAL 100 (805) Q Consensus 21 ieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqal 100 (805) -++++.++++.++.....+-...+++.|.++++.+.+..+....+-.+.+.+..+..+...-+....+..-..+-+++.+ T Consensus 11 ~~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~l~~~ 90 (621) T 6S1Y_A 11 SETEISQIVEWIEQRYQQTKAHQTLAAWEYGSNLTEFNLSKKTKAAADFAEVAKAVAEELQQFKTDQLTNATLKRRIKKL 90 (621) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHHHHTTSCSSSCCCHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHHHHHHhHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCHHHHHHHHHH Confidence 34677889999999999999999999999999999988887666777777777654432111111122233455566666 Q sp|Q9BYF1|ACE2 101 QQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNP-QECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL 179 (805) Q Consensus 101 qqngssvlsedkskrlntilntmstiystgkvcnpdnp-qeclllepglneimansldynerlwaweswrsevgkqlrpl 179 (805) ...+...|+++..+++..++..++.+|++..+|.++.+ .+++.+.+.+..+|+++-|...|--+|++|++..+..+.++ T Consensus 91 ~~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~ 170 (621) T 6S1Y_A 91 AKLGYAALPADQFKELLGAIASMESNYAKAKFCAYGDATKCDLSLDPELTEIFANHREPEELKYYWVQWYNATGAPVRES 170 (621) T ss_dssp TCCGGGGSCHHHHHHHHHHHHHHHHHHHHCCBCBTTBTTCCCBCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHTGGGHHH T ss_pred HHhccccCCHHHHHHHHHHHHHHHHHHHhhccccCCCCCCCcccCChHHHHHHHhCCCHHHHHHHHHHHHHhcChhHHHH Confidence 66666678888777788888899999999888765422 23455668899999999999999999999999888899999 Q sp|Q9BYF1|ACE2 180 YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISP 258 (805) Q Consensus 180 yeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yisp 258 (805) +.+.|-+++++|+...|.+|.+|+..++++ +.+.+-++..++.++|+++.+++|++.++...|.. -+++ T Consensus 171 l~~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~v~~~l~~l~~~v~~~~~~~~~~~~~~~~~~~g~~~~~~ 240 (621) T 6S1Y_A 171 FQKYVELNRQAALRNNFSSGAAVWLNEYDD----------STFEQQVDDVIEQIRPLYEQLHAYVRYKLRQKYGDKLVSP 240 (621) T ss_dssp HHHHHHHHHHHHHHTTCSSHHHHHHHTTCC----------TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTSCS T ss_pred HHHHHHHHHHHHHHCCCCCHHHHHHhcCCc----------hhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccCCCCC Confidence 999999999999999999999999876642 34556677788899999999999999987554432 3456 Q sp|Q9BYF1|ACE2 259 IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGN 338 (805) Q Consensus 259 igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgn 338 (805) -+-+|+|+||.+|+.-|..+|.+..|+.+....++++.++.+-+..+++++.++++|-++|+..++..||++++...|.. T Consensus 241 ~~~ip~~~l~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~w~~~v~~~~~~ 320 (621) T 6S1Y_A 241 TGPIPMHLLGNLWAQTWDNIADFTTPFPEKKLLDVTDEMIRQGYTPIKMFQMGDDFFTSLNMTKLPQTFWDKSILEKPTD 320 (621) T ss_dssp SSCEEGGGSSSTTCSCCGGGTTTTCSCTTSCCCCCHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSS T ss_pred CCCCcHHHhhcchhccchhhhhhcCCCCCcccCCCcHHHHHCCCCHHHHHHHHHHHHHHCCCCCCChhHhhhhhccCCCC Confidence 78999999999999999999999999876666778888988888899999999999999999999999999999875432 Q sp|Q9BYF1|ACE2 339 VQKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKH 417 (805) Q Consensus 339 vqkavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkh 417 (805) -....|||..+.+.. +|.||++|+..+.+|+.|.+||+||..|.+.+..||++.+.+++.+|+|+++++|+..+.+|.+ T Consensus 321 ~k~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~~~~~~~~~p~~~~~~~~~~~~E~~s~~~e~~~~~~~~ 400 (621) T 6S1Y_A 321 GRDLVCHASAWDFFAIDDVRIKQCTRVNMREFFVVHHELGHIQYYLQYQHQPVEFRGGANPGFHEAVGDVLSLSVSTPKH 400 (621) T ss_dssp CCCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHHTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHH T ss_pred CCCCCCchhhhhccCCCCEEEEeCCCCCHHHHHHHHHHHHHHHHHHHhccCCchhcCCCChHHHHHHHHHHHHHhcCHHH Confidence 222468888888875 6999999999999999999999999999999999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 418 LKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 418 lksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) |+.++++.. .....+..++.++++++..+..+|+..++.+|++.++.|.+..+.+-+.||+...+..|+..|.+.++.. T Consensus 401 L~~~~l~~~-~~~~~~~~~~~l~~~~l~~l~~~~~~~~~d~fe~~l~~~~~~~~~l~~~~~~l~~~y~g~~~~~~~~~~~ 479 (621) T 6S1Y_A 401 LKKVGLLKD-YEEDEQVKINQFYRAGVTKLVFLPFAYTLDKYRWGVFRGDIKPREYNCKFWEMRSRYSGVEPPVVRTEQD 479 (621) T ss_dssp HHHTTSSCC-CCCCHHHHHHHHHHHCCCCCTHHHHHHHHHHHHHHHHHTSSCGGGHHHHHHHHHHHHHCEECSSCEETTC T ss_pred HHHcCCCCC-CCCCHHHHHHHHHHHHHHHhhhhHHHHHHHHHHHHHHcCCCChHHHHHHHHHHHHHHcCCCCCCCCChhh Confidence 999998753 3333345667888899999999999889999999999998877888999999999999976665566677 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALE 571 (805) Q Consensus 498 cdpaslfhvsndysfiryytrtlyqfqfqealcqaakh------egplhkcdisnsteagqklfnmlrlgksepwtlale 571 (805) .||+...|+.....++.|....+..+|+-+.+|+...+ ++|||.||+..+.++|.++.++|+.|.+.+|.-.++ T Consensus 480 ~~~~~~~H~~~~~~~~~Y~~~~~~a~qi~~~~~~~~~~~~~~~~~~~l~~c~~~~~~~~~~~~~~~l~~G~s~~~~ell~ 559 (621) T 6S1Y_A 480 FDPPAKYHVSADVEYLRYFVSYVIQFQFHRAACALAGEYVKGDPEKTLNNCDIYQSTAAGNQLKEMLALGSSKPWPDAME 559 (621) T ss_dssp CCGGGSHHHHTTCCSHHHHHHHHHHHHHHHHHHHHTTCCCTTCTTSCTTSCCCTTCHHHHHHHHHHHHTTTSSCHHHHHH T ss_pred CCcchheeecCCchHHHHHHHHHHHHHHHHHHHHHhCCccCCCCCCCcccCCccCCHHHHHHHHHHHhcCCCCCHHHHHH Confidence 88888888875556888999999999999999987643 579999999999999999999999999999999999 Q sp|Q9BYF1|ACE2 572 NVVGAKNMNVRPLLNYFEPLFTWLKDQNKN--SFVGWSTDW 610 (805) Q Consensus 572 nvvgaknmnvrpllnyfeplftwlkdqnkn--sfvgwstdw 610 (805) ...|....+..+++.||+|+.+||+.+|++ --+||..+| T Consensus 560 ~~~G~d~~s~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~ 600 (621) T 6S1Y_A 560 VLTGERKMSADAILEYFDPLYQWLLEENKRLGAHVGWTDSQ 600 (621) T ss_dssp HHHSCCSCCTHHHHHHTHHHHHHHHHHHHHHTCCCSCCCCC T ss_pred HHHCCCCCChHHHHHHHHHHHHHHHHHHHHhCCCCCCCccc Confidence 999988889999999999999999988875 459999775 No 8 >4CA5_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.2.1.-, 3.4.15.1); HYDROLASE, ZINC METALLOPEPTIDASE, INHIBITOR BINDING; HET: FUC, 3EF, ACT, NAG; 1.85A {HOMO SAPIENS} Probab=100.00 E-value=3.9e-58 Score=435.55 Aligned_cols=578 Identities=43% Similarity=0.863 Sum_probs=497.1 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) +..++.|++.++.+...+-...+++.|.++++.+++..+....+-.+.+.++.+..++...|..+.+.+-..+-+++.+. T Consensus 5 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 84 (589) T 4CA5_A 5 EAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQ 84 (589) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTSCCHHHHHHHHHHHHHHHHHHHHHHHHHHTSCGGGCCCHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcChhhCCCHHHHHHHHHHH Confidence 56778999999999999999999999999999999999988888888888888777766655333444445566666666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYE 181 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrplye 181 (805) ..+...|+++.-+++..+...+..+|++..+|.++ .+|+.+.+.+..+|.++-|...|--+|++|+...+..+.+.+. T Consensus 85 ~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~--g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~l~ 162 (589) T 4CA5_A 85 DLERAALPAQELEEYNKILLDMETTYSVATVCHPN--GSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYP 162 (589) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCCEECTT--SCEECCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHTTTHH T ss_pred hhhhccCCHHHHHHHHHHHHHHHhhhccceecCCC--CCeecCChhHHHHHhhCCCHHHHHHHHHHHHHHhhHHHHHHHH Confidence 66667888887777788888899999998888775 3567777889999999999999999999999988889999999 Q sp|Q9BYF1|ACE2 182 EYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPIG 260 (805) Q Consensus 182 eyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispig 260 (805) +.+-+++++|+...|.+|.+||..+|+. +.+.+.++..++.++|+|+.+|+|++.++...|.. -++.-+ T Consensus 163 ~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~v~~~l~~l~~~v~p~~~~l~~~~~~~~~~~~g~~~~~~~~ 232 (589) T 4CA5_A 163 KYVELINQAARLNGYVDAGDSWRSMYET----------PSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEG 232 (589) T ss_dssp HHHHHHHHHHHHTTCSSHHHHHHGGGCC----------TTHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHCTTTCCTTS T ss_pred HHHHHHHHHHHHcCCCCHHHHHHHccCC----------ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccCCCCC Confidence 9999999999999999999999887732 33457788889999999999999999987554431 133446 Q sp|Q9BYF1|ACE2 261 CLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQ 340 (805) Q Consensus 261 clpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvq 340 (805) -.|+|++|.+|+.-|+++|....||......++++.+..+.+...++++.++.+|-++|+..+...+|+++....++.-. T Consensus 233 ~~p~~~~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~~~~d~~~r~~K~~ 312 (589) T 4CA5_A 233 PIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGR 312 (589) T ss_dssp CEETTSSSSTTSSCCGGGHHHHCSCTTSCCCCHHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSSSC T ss_pred CCcHHHhhhhhhhccccchhhcCCCCCCCCCCcHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHhchhhccCCCCCC Confidence 78999999999999999999999998888888888888888888999999999999999877888899998887777665 Q sp|Q9BYF1|ACE2 341 KAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLK 419 (805) Q Consensus 341 kavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlk 419 (805) ...|||..+++.. ++.||++|...+.+++.|.+||+||..+.+.+..+|++.+.+++-+|+|+++++|+..+.+|.+|+ T Consensus 313 ~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~~l~ 392 (589) T 4CA5_A 313 EVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLH 392 (589) T ss_dssp CCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHSTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHHHH T ss_pred CceecceeEeCcCCCcEEEEEcCCCCHHHHHHHHHHHHHHHHHHHcCCCCHHHccCCChHHHHHHHHHHHHHhcCHHHHH Confidence 6789999998864 689999999999999999999999999999988999999888999999999999999999999999 Q sp|Q9BYF1|ACE2 420 SIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 499 (805) Q Consensus 420 sigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycd 499 (805) .++++... +.+.+..++.++.+++..+..+|+.++++.|.+.++.|.+..+.+-+-||+...+.-|+..|.+......| T Consensus 393 ~~~~~~~~-~~~~~~~~~~l~~~~l~~~~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~~~~~y~g~~~~~~~~~~~~~ 471 (589) T 4CA5_A 393 SLNLLSSE-GGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFD 471 (589) T ss_dssp HTTSSCCC-CSCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTSSCTTTHHHHHHHHCCCCCCEECSSCCCTTCCG T ss_pred HcCCCCCC-CCChHHHHHHHHHHHHHHHhhchHHHHHHHHHHHHhCCCCChHhHHHHHHHHHHHHcCCCCCCCCChhhCC Confidence 99987653 22334456788999999999999999999999999999888888999999988888887655444455677 Q sp|Q9BYF1|ACE2 500 PASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNM 579 (805) Q Consensus 500 paslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvgaknm 579 (805) |++..|......+..|....+..+|+-+.+|+...+.||+|.|++..+.++|.++.++|+.|.+.||.-.++.+.|.... T Consensus 472 ~~~~~H~~~~~y~y~Y~~~~~~a~~l~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~l~~G~~~~~~ell~~~~g~d~~ 551 (589) T 4CA5_A 472 PGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNM 551 (589) T ss_dssp GGGSTTTTTTCCCHHHHHHHHHHHHHHHHHHHHTTCCSCGGGCCCTTCHHHHHHHHHHHHTTTSSCHHHHHHHHHSSCSC T ss_pred ccccccCCCCchhHHHHHHHHHHHHHHHHHHHHcCCCCCchhCCccCCHHHHHHHHHHHhcCCCCCHHHHHHHHHCCCCC Confidence 77888887666778888888999999999999888889999999998899999999999999999999999999998888 Q sp|Q9BYF1|ACE2 580 NVRPLLNYFEPLFTWLKDQNKNS--FVGWST-DWSP 612 (805) Q Consensus 580 nvrpllnyfeplftwlkdqnkns--fvgwst-dwsp 612 (805) ++.+++.+|+||..||+.+|+.. -+||.. .|.| T Consensus 552 ~~~~~~~~~~~l~~~l~~~~~~~~~~~g~~~~~~~~ 587 (589) T 4CA5_A 552 SASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTP 587 (589) T ss_dssp CSHHHHHHHHHHHHHHHHHHHHTTCCCSCSSTTCCC T ss_pred ChHHHHHhHHHHHHHHHHHHHhhCCccCCcccCCCC Confidence 99999999999999999998754 489988 7876 No 9 >5A2R_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1); HYDROLASE, ANGIOTENSIN CONVERTING ENZYME, DROSOPHILA; HET: NAG; 1.85A {DROSOPHILA MELANOGASTER} Probab=100.00 E-value=2.8e-56 Score=425.09 Aligned_cols=579 Identities=37% Similarity=0.721 Sum_probs=483.2 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) ++...++|++++.....+-.....+.|.++++.+++..+..+.+..+.+.+.++.......|.++....-..+-+|+.+. T Consensus 5 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 84 (598) T 5A2R_A 5 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALT 84 (598) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHHHGGGSCGGGCSCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhcHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHhcchhcchhhCCCHHHHHHHHHHH Confidence 35677899999999999999999999999999999988877777888888887766655444422222233455566666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDN-PQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdn-pqeclllepglneimansldynerlwaweswrsevgkqlrply 180 (805) ..+...|+++.-++++..+..++.+|++...|..+. ...++.+.+.+..+|+++-|...|--+|+.|+...+..+.+.+ T Consensus 85 ~~~~~~L~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~l 164 (598) T 5A2R_A 85 KLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQF 164 (598) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCCBCCSSCTTCCCBCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHTGGGHHHH T ss_pred HhcccCCCHHHHHHHHHHHHHHHHHHhccccCCCCCCCCCcccCCHHHHHHHHcCCCHHHHHHHHHHHHHHccHHHHHHH Confidence 677778888888888888889999999887776432 1245566788999999999999999999999998888999999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPI 259 (805) Q Consensus 181 eeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispi 259 (805) .+.+-+++++|+...|++|.+|+..+++ ...+.+-++..++.|+|+|+.+|+|++.++...|.. -++.- T Consensus 165 ~~l~~~r~~~A~~~Gy~s~~~~~l~~~~----------~~~v~~~l~~l~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~ 234 (598) T 5A2R_A 165 ERYVELNTKAAKLNNFTSGAEAWLDEYE----------DDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSET 234 (598) T ss_dssp HHHHHHHHHHHHHTTCSSHHHHHHGGGC----------CTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTSCSS T ss_pred HHHHHHHHHHHHHCCCCCHHHHHHhccC----------CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCccccCCC Confidence 9999999999999999999999976543 223345566677889999999999999987554321 12334 Q sp|Q9BYF1|ACE2 260 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339 (805) Q Consensus 260 gclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnv 339 (805) +-+|+|++|++|++-|..+|.+..|+.+++..++++.+....+....+++-++++|-++|+..+..++|++++...|..- T Consensus 235 ~~~p~~l~g~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~w~~~~~~~~~~~ 314 (598) T 5A2R_A 235 GPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDG 314 (598) T ss_dssp SCEEGGGSSSTTCSCCGGGHHHHCSCTTSCCCCTHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSSC T ss_pred CCCCHHHhhchhhhhhHhhhhhcCCCCCCCCCCchHHHHHCCCCHHHHHHHHHHHHHhCCCCCCChhhhhhhhccCCCCC Confidence 56799999999999999999999999888777888888777788899999999999999999988999999987644321 Q sp|Q9BYF1|ACE2 340 QKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHL 418 (805) Q Consensus 340 qkavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhl 418 (805) ....|||.++.+.. ++.||++|...+.+|+.|.+||+||..+.+.+..||++.+++.+.+|+|+++++|++.+.+|.+| T Consensus 315 k~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~~L 394 (598) T 5A2R_A 315 RDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHL 394 (598) T ss_dssp CCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHHH T ss_pred CCCccccceEeCcCCCCeEEEecCCCCHHHHHHHHHHHHHHHHHHHccCCChhHccCCChHHHHHHHHHHHHHhcCHHHH Confidence 11358888888774 68999999999999999999999999999999889999999999999999999999999999999 Q sp|Q9BYF1|ACE2 419 KSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYC 498 (805) Q Consensus 419 ksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc 498 (805) +.++++. ....+.+..++.++.+++..+..+|+......|++-++.|++....+-+.||+...+.-|++.|.+.+...+ T Consensus 395 ~~~~~~~-~~~~~~~~~~~~l~~~~l~~l~~l~~~~~~~~~e~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~ 473 (598) T 5A2R_A 395 EKIGLLK-DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDF 473 (598) T ss_dssp HHTTSSC-SCCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTCSCGGGHHHHHHHHHHHHHCEECSSCEETTCC T ss_pred HHcCCCC-ccCCChHHHHHHHHHHHHHHhhhcHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCChhhC Confidence 9999874 333444567788899999999999998888999999999988778899999999999989876655555557 Q sp|Q9BYF1|ACE2 499 DPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572 (805) Q Consensus 499 dpaslfhvsndysfiryytrtlyqfqfqealcqaakh------egplhkcdisnsteagqklfnmlrlgksepwtlalen 572 (805) ++++..|+..+..++.|....+..+|+-+.+|+...+ .||+|.||...+.++|+++.++|+.|.+.||.-.++. T Consensus 474 ~~~~~~hi~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~G~s~~~~e~~~~ 553 (598) T 5A2R_A 474 DAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEA 553 (598) T ss_dssp CGGGSHHHHTTCCCHHHHHHHHHHHHHHHHHHHHTTCCCTTCTTSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHH T ss_pred CCccceeecCCchHHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCchhCCccCCHHHHHHHHHHHhcCCCCCHHHHHHH Confidence 7888888775556788888889999999998886544 6799999999889999999999999999999999999 Q sp|Q9BYF1|ACE2 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNSF--VGWSTDWS 611 (805) Q Consensus 573 vvgaknmnvrpllnyfeplftwlkdqnknsf--vgwstdws 611 (805) ..|..-.+..+++.+|.|+-.||+.+|+..- +||..+|. T Consensus 554 ~~G~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~~w~~~~~ 594 (598) T 5A2R_A 554 FNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNK 594 (598) T ss_dssp HHSCCSCCSHHHHHHHHHHHHHHHHHHHHTTCCCSCCCCSC T ss_pred HhCCCCCChHHHHHHHHHHHHHHHHhHHhcCCcCCccCCCc Confidence 9999878999999999999999999987665 99999873 No 10 >4ASR_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1), BRADYKININ; HYDROLASE, ZINC METALLOPROTEASE, SUBSTRATE RECOGNITION; HET: MAN, NAG, FLC, BMA; 1.9A {DROSOPHILA MELANOGASTER} Probab=100.00 E-value=2.9e-56 Score=426.35 Aligned_cols=578 Identities=37% Similarity=0.724 Sum_probs=486.1 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) +.+...||..++.....+-....++.|.++++.+++..+..+.+..+.+.+..+..+.+..|.++...+-..+-+|+.+. T Consensus 6 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 85 (598) T 4ASR_A 6 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALT 85 (598) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHHHGGGSCGGGCSCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHhcchhcchhcCCCHHHHHHHHHHH Confidence 46678899999999999999999999999999999988888788888888888777666555533333334555666666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDN-PQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdn-pqeclllepglneimansldynerlwaweswrsevgkqlrply 180 (805) ..+...|+++.-++++..+..+..+|++...|.... ..+++.+.|.+..+|.++-|...|--+|++|++..+..+.+++ T Consensus 86 ~~~~~~L~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~~l 165 (598) T 4ASR_A 86 KLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQF 165 (598) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCCBCCSSCTTCCCBCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHTGGGHHHH T ss_pred HhccccCCHHHHHHHHHHHHHHHHHhhccccCCCCCCCCccccCCHHHHHHHHcCCCHHHHHHHHHHHHHHhcHHHHHHH Confidence 666678888888888888899999999887776432 1255566788999999999999999999999998888999999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPI 259 (805) Q Consensus 181 eeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispi 259 (805) .+.+-+++++|+...|.+|.+|+..++ +...+.+-++..++.++|+++.+|+|+|.++...|.. .+++- T Consensus 166 ~~lv~~r~~~A~~~Gy~s~~~~~l~~~----------~~~~v~~~l~~l~~~i~~~~~~l~~~~~~~~~~~~~~~~~~~~ 235 (598) T 4ASR_A 166 ERYVELNTKAAKLNNFTSGAEAWLDEY----------EDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSET 235 (598) T ss_dssp HHHHHHHHHHHHHTTCSSHHHHHHGGG----------CCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTSCSS T ss_pred HHHHHHHHHHHHHCCCCCHHHHHHhcc----------CCccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccCCC Confidence 999999999999999999999997654 2334445666778889999999999999987554432 13334 Q sp|Q9BYF1|ACE2 260 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339 (805) Q Consensus 260 gclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnv 339 (805) +-+|+|++|++|++-|..+|.+..|+...+..++++.++.+.+...++|+-++++|-++|+..+..+||++++...+.. T Consensus 236 ~~~p~~l~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~w~~~~~~~~~~- 314 (598) T 4ASR_A 236 GPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTD- 314 (598) T ss_dssp SCEEGGGSSSTTSSCCGGGHHHHCSCTTSCCCCCHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCSS- T ss_pred CCCcHHHccccchhcchhhhhhcCCCCCCCCCCccHHHHHCCCCHHHHHHHHHHHHHhCCCCCCChHHhhhhhccCCCC- Confidence 6689999999999999999999999987776677777878888889999999999999999988889999998765432 Q sp|Q9BYF1|ACE2 340 QK-AVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKH 417 (805) Q Consensus 340 qk-avchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkh 417 (805) .| ..|||.++++.. ++.||++|+..+.+|+.|.+||+||..+.+.+..+|++.+.+.+.+|+|+++++|++.+.+|.+ T Consensus 315 ~k~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~d~~E~~s~~~e~~~~~~~~ 394 (598) T 4ASR_A 315 GRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKH 394 (598) T ss_dssp SCCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHHTTSCGGGSSCSSHHHHHHHHHHHHHHHTSHHH T ss_pred CCCCcccchhhhccCCCCEEEEecCCCCHHHHHHHHHHHHHHHHHHHccCCChHHccCCChHHHHHHHHHHHHHhcCHHH Confidence 22 368888888875 5899999999999999999999999999999988999999889999999999999999999999 Q sp|Q9BYF1|ACE2 418 LKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 418 lksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) |+.++++. ..+...+..++.++++++..+..+|+..+...|++-++.|++..+.+.+.||+...+..|+..|.+.++.. T Consensus 395 L~~~~~~~-~~~~~~~~~~~~l~~~~l~~~~~l~~~~~~~~~e~~~~~~~~~~~~~~~~~~~l~~~~~g~~~~~~~~~~~ 473 (598) T 4ASR_A 395 LEKIGLLK-DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKD 473 (598) T ss_dssp HHHTTSSC-SCCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTCSCGGGHHHHHHHHCCCCCCEECSSCEETTC T ss_pred HHHcCCCC-ccCCChHHHHHHHHHHHHHHhhhhHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCChhh Confidence 99999864 33334455678888999999999999888899999999998877889999999999998987665555555 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALE 571 (805) Q Consensus 498 cdpaslfhvsndysfiryytrtlyqfqfqealcqaakh------egplhkcdisnsteagqklfnmlrlgksepwtlale 571 (805) .+|.+..|+..+..+..|....+..+|+-+.+|+.+.+ +||+|.|+...+.++|.++-++|..|.+.||.-.++ T Consensus 474 ~~~~~~~h~~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~l~~G~s~~~~el~~ 553 (598) T 4ASR_A 474 FDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALE 553 (598) T ss_dssp CCGGGSHHHHTTCCSHHHHHHHHHHHHHHHHHHHHTTCCCTTCTTSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHH T ss_pred CCCccceeecCCchhHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCchhCCccCCHHHHHHHHHHHhcCCCCCHHHHHH Confidence 56777778765555788888888999999999887554 689999999988999999999999999999999999 Q sp|Q9BYF1|ACE2 572 NVVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWS 611 (805) Q Consensus 572 nvvgaknmnvrpllnyfeplftwlkdqnkns--fvgwstdws 611 (805) ...|..-.+..+++.+|+|+-.||+.+|+.. -+||.++|- T Consensus 554 ~~~G~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~~ 595 (598) T 4ASR_A 554 AFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNK 595 (598) T ss_dssp HHHSCCSCCSHHHHHHHHHHHHHHHHHHHHTTCCCSCCCCCS T ss_pred HHhCCCCCChHHHHHHHHHHHHHHHHhhhhcCccccccCCCc Confidence 9999988899999999999999999988755 499999884 No 11 >4CA7_A ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1); HYDROLASE, ZINC METALLOPEPTIDASE, INHIBITOR BINDING; HET: MAN, NAG, 3EF, BMA; 1.82A {DROSOPHILA MELANOGASTER} Probab=100.00 E-value=3.2e-56 Score=426.00 Aligned_cols=578 Identities=37% Similarity=0.724 Sum_probs=485.3 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) +.+...||..++.....+-....++.|.++++.+++..+..+.+..+.+.+..+..+.+..|.++...+-..+-+|+.+. T Consensus 6 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~ 85 (598) T 4CA7_A 6 EIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALT 85 (598) T ss_dssp GC-CHHHHHHHHHHHHHHHHHHHHHHHHHHTSCCHHHHHHHHHHHHHHHHHHHHHHHHHTTSCGGGCSCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHhCHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHhcchhcchhcCCCHHHHHHHHHHH Confidence 46678899999999999999999999999999999988888788888888888777666555533333334555666666 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDN-PQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdn-pqeclllepglneimansldynerlwaweswrsevgkqlrply 180 (805) ..+...|+++.-++++..+..+..+|++...|.... ..+++.+.|.+..+|.++-|...|--+|++|++..+..+.+++ T Consensus 86 ~~~~~~L~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~g~~~~l~~~~~~~l~~~~~~~~R~~~~~~~~~~~~~~~~~~l 165 (598) T 4CA7_A 86 KLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQF 165 (598) T ss_dssp CCGGGGSCHHHHHHHHHHHHHHHHHHHHCEECCSSCTTCCCEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHTGGGHHHH T ss_pred HhccccCCHHHHHHHHHHHHHHHHHhhccccCCCCCCCCccccCCHHHHHHHHcCCCHHHHHHHHHHHHHHhcHHHHHHH Confidence 666678888888888888899999999887776432 1255566788999999999999999999999988778899999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YISPI 259 (805) Q Consensus 181 eeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yispi 259 (805) .+.+-+++++|+...|.+|.+|+..++ +...+.+-++..++.++|+++.+|+|+|.++...|.. .+++- T Consensus 166 ~~lv~~r~~~A~~~Gy~s~~~~~l~~~----------~~~~v~~~l~~l~~~i~~~~~~l~~~~~~~~~~~~~~~~~~~~ 235 (598) T 4CA7_A 166 ERYVELNTKAAKLNNFTSGAEAWLDEY----------EDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSET 235 (598) T ss_dssp HHHHHHHHHHHHHTTCSSHHHHHHGGG----------CCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTSCSS T ss_pred HHHHHHHHHHHHHCCCCCHHHHHHhcc----------CCccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccCCC Confidence 999999999999999999999997654 2334445666778889999999999999987554432 13334 Q sp|Q9BYF1|ACE2 260 GCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339 (805) Q Consensus 260 gclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnv 339 (805) +-+|+|++|++|++-|..+|.+..|+...+..++++.++.+.+...++|+-++++|-++|+..+..+||++++...+.. T Consensus 236 ~~~p~~l~~~~~~~~w~~~~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~w~~~~~~~~~~- 314 (598) T 4CA7_A 236 GPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTD- 314 (598) T ss_dssp SCEEGGGSSSTTCSCCGGGHHHHCSCTTSCCCCCHHHHHHTTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCCS- T ss_pred CCCcHHHccccchhcchhhhhhcCCCCCCCCCCccHHHHHCCCCHHHHHHHHHHHHHhCCCCCCChHHhhhhhccCCCC- Confidence 6689999999999999999999999987776677777878888889999999999999999988889999998765432 Q sp|Q9BYF1|ACE2 340 QK-AVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKH 417 (805) Q Consensus 340 qk-avchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkh 417 (805) .| ..|||.++++.. ++.||++|+..+.+|+.|.+||+||..+.+.+..+|++.+.+.+.+|+|+++++|++.+.+|.+ T Consensus 315 ~k~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~d~~E~~s~~~e~~~~~~~~ 394 (598) T 4CA7_A 315 GRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKH 394 (598) T ss_dssp SCCCCCSCEEEECSSSSCEEEECCCCSSHHHHHHHHHHHHHHHHHHHTTTSCGGGCSCSSHHHHHHHHHHHHHHHTSHHH T ss_pred CCCCcccchhhhccCCCCEEEEecCCCCHHHHHHHHHHHHHHHHHHHccCCChHHccCCChHHHHHHHHHHHHHhcCHHH Confidence 22 368888888875 5899999999999999999999999999999988999999889999999999999999999999 Q sp|Q9BYF1|ACE2 418 LKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 418 lksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) |+.++++. ..+...+..++.++++++..+..+|+..+...|++-++.|++..+.+.+.||+...+..|+..|.+.++.. T Consensus 395 L~~~~~~~-~~~~~~~~~~~~l~~~~l~~~~~l~~~~~~~~~e~~~~~~~~~~~~~~~~~~~l~~~~~g~~~~~~~~~~~ 473 (598) T 4CA7_A 395 LEKIGLLK-DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKD 473 (598) T ss_dssp HHHTTCSC-SCCCCHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHTTCSCGGGHHHHHHHHCCCCCCEECSSCEETTC T ss_pred HHHcCCCC-ccCCChHHHHHHHHHHHHHHhhhhHHHHHHHHHHHHHHcCCCCHHHHHHHHHHHHHHHcCCCCCCCCChhh Confidence 99999864 33334455678888999999999999888899999999998877889999999999998987665555555 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALE 571 (805) Q Consensus 498 cdpaslfhvsndysfiryytrtlyqfqfqealcqaakh------egplhkcdisnsteagqklfnmlrlgksepwtlale 571 (805) .+|.+..|+..+..+..|....+..+|+-+.+|+.+.+ +||+|.|+...+.++|.++-++|..|.+.||.-.++ T Consensus 474 ~~~~~~~h~~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~~~~~l~~G~s~~~~el~~ 553 (598) T 4CA7_A 474 FDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALE 553 (598) T ss_dssp CCGGGSHHHHTTCCCHHHHHHHHHHHHHHHHHHHHTTCCCTTCTTSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHH T ss_pred CCCccceeecCCchhHHHHHHHHHHHHHHHHHHHHcCCCCCCCCCCCchhCCccCCHHHHHHHHHHHhcCCCCCHHHHHH Confidence 56777778765555788888888999999999887554 689999999988999999999999999999999999 Q sp|Q9BYF1|ACE2 572 NVVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWS 611 (805) Q Consensus 572 nvvgaknmnvrpllnyfeplftwlkdqnkns--fvgwstdws 611 (805) ...|..-.+..+++.+|+|+-.||+.+|+.. -+||.++|- T Consensus 554 ~~~G~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~gw~~~~~ 595 (598) T 4CA7_A 554 AFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNK 595 (598) T ss_dssp HHHSCCSCCTHHHHHHHHHHHHHHHHHHHHTTCCCSCCCCCS T ss_pred HHhCCCCCChHHHHHHHHHHHHHHHHhhhhcCccccccCCCc Confidence 9999988899999999999999999988755 499999884 No 12 >2C6F_A ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM (E.C.3.4.15.1); HYDROLASE, ANGIOTENSIN-I CONVERTING ENZYME, N; HET: ACT, GOL, NAG; 3.01A {HOMO SAPIENS} Probab=100.00 E-value=2.3e-52 Score=400.71 Aligned_cols=579 Identities=43% Similarity=0.828 Sum_probs=477.2 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMY-P--LQEIQNLTVKLQLQ 98 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmy-p--lqeiqnltvklqlq 98 (805) +++...|+++++.....+--..+.+.|.++++++++..+....+..+.+.|..+.+....-. . +++...-..+-.|+ T Consensus 14 ~~~~~~~l~~~~~~~~~l~~~~~~a~~~~~~d~~~~~~~~~~~~~~~~~~~~~~l~~~~~~l~~~~~~~~~~~~~~~~l~ 93 (612) T 2C6F_A 14 EAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIG 93 (612) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTSCSCHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcchHhhCCCHHHHHHHH Confidence 46677899999999999999999999999999998877666666666666655444321110 0 11111112233344 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRP 178 (805) Q Consensus 99 alqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevgkqlrp 178 (805) .+...+...|+++..+++..+...++.+|++-.+|..+.+.+|+.+.+.+..+|.++-|...|--+|++|+...+..+.+ T Consensus 94 ~l~~~~~~~L~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~l~~~~d~~~R~~~~~~~~~~~~~~~~~ 173 (612) T 2C6F_A 94 AVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKP 173 (612) T ss_dssp HHSCCGGGGSCHHHHHHHHHHHHHHHHHHHHCEECCSSCCCCCEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHhhcccCCHHHHHHHHHHHHHHHHHHHhccccCCCCCCCcccCChhHHHHHhhCCCHHHHHHHHHHHHHHhCcccHH Confidence 45455556788887777888888999999999988777666788888899999999999999999999999877788999 Q sp|Q9BYF1|ACE2 179 LYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPS-YIS 257 (805) Q Consensus 179 lyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnayps-yis 257 (805) ++.+.+-+++++|+...|++|.+|+..++.. ....+-++...+.++|++..+|+|++.++...+-. .++ T Consensus 174 ~l~~lv~~r~~~A~~~Gy~s~~~~~l~~~~~----------~~~~~~l~~l~~~~~~~~~~~~~~~~~~~~~~~g~~~~~ 243 (612) T 2C6F_A 174 LYEDFTALSNEAYKQDGFTDTGAYWRSWYNS----------PTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYIN 243 (612) T ss_dssp HHHHHHHHHHHHHHTTTCSSHHHHHHGGGCC----------TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTTCC T ss_pred HHHHHHHHHHHHHHHcCCCCHHHHHHHhhCC----------CcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccC Confidence 9999999999999999999999999776542 23345566777888999999999999987554321 233 Q sp|Q9BYF1|ACE2 258 PIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPG 337 (805) Q Consensus 258 pigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpg 337 (805) .-+-+|.|++|++|+..|+.+|...+|+.++...++++++....+...++++.++++|-++|+..+...+|+++....|| T Consensus 244 ~~~~lp~d~~~~~~~~~~~~~~~~~~p~~~~~~~~i~~~~~~~~~~~~~~~~~~~~~~~~lg~~~~~~~~w~~~~~~r~~ 323 (612) T 2C6F_A 244 LRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPA 323 (612) T ss_dssp TTSCEETTSSSSTTCSCCGGGHHHHCSSCSSCCSCTHHHHHHHTCCHHHHHHHHHHHHHHTTCCCCCHHHHHHCBCSCCS T ss_pred CCCCCcHHHccCcchhcchhhhhhhCCCCCCCCCCCcHHHHhCCCCHHHHHHHHHHHHHhcCCCCCChhhhccccccCCC Confidence 34456999999999999999999999998777677778877777888899999999999999998888999999877777 Q sp|Q9BYF1|ACE2 338 NVQKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPK 416 (805) Q Consensus 338 nvqkavchptawdlgk-gdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpk 416 (805) .-....||+.++++.. ++.||++|...+.+|+.|.+||+||..+.+.+..+|++.++.++.+|+|+++++|+..+.+|. T Consensus 324 K~~~~~~~a~~~~~~~~~~~~i~~~~~~~~~~~~tl~HElGHa~h~~~~~~~~~~~~~~~~~~~~E~~s~~~e~~~~~~~ 403 (612) T 2C6F_A 324 DGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPE 403 (612) T ss_dssp SSCCCCCSCEEEECSSSSCEEEECCCCSCHHHHHHHHHHHHHHHHHHHHTTSCGGGCSCSSHHHHHHHHHHHHHHHHSHH T ss_pred CCCcceecchhhhCcCCCcEEEEEcCCCCHHHHHHHHHHHHHHHHHHHccCCCHHHccCCChHHHHHHHHHHHHHhcCHH Confidence 6655678888887764 689999999999999999999999999999988899998888889999999999999999999 Q sp|Q9BYF1|ACE2 417 HLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDET 496 (805) Q Consensus 417 hlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdet 496 (805) .|+.++++.. .+...+..++.++++++..+..+|+..+++.|+|.++.|.++.+.+-+.||+...+..|...|.+.+++ T Consensus 404 ~L~~~~~~~~-~~~~~~~~~~~l~~~~l~~l~~l~~~~~~d~~~~~~~~~~~~~~~l~~~~~~l~~~y~g~~~~~~~~~~ 482 (612) T 2C6F_A 404 HLHKIGLLDR-VTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNET 482 (612) T ss_dssp HHHHTTSCCC-CCCSHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHTSSCGGGHHHHHHHHHHHHHCEECSSCCCTT T ss_pred HHHHcCCCCC-CCCCcHHHHHHHHHHHHHHhhccHHHHHHHHHHHHHhcCCCChhhHHHHHHHHHHHHcCCCCCCCCChh Confidence 9999988753 222234456788899999999999999999999999999888888999999988888887655555666 Q sp|Q9BYF1|ACE2 497 YCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGA 576 (805) Q Consensus 497 ycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnmlrlgksepwtlalenvvga 576 (805) ..||++..|+..+...+.|....+..+|+-+.+|+...+.+|+|+||+..+.++|+++.++|+.|.+.+|.-.++...|. T Consensus 483 ~~~~~~~~h~~~~~~yy~Y~~s~~~a~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~L~~G~s~~~~el~~~~~G~ 562 (612) T 2C6F_A 483 HFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGL 562 (612) T ss_dssp CCGGGGSTTTTTTCCCHHHHHHHHHHHHHHHHHHHHHTCCSCGGGCCCTTCHHHHHHHHHHHTTTTSSCHHHHHHHHHSC T ss_pred cCCcccceecCCChhhHHHHHHHHHHHHHHHHHHHHcCCCCChhhCCccCCHHHHHHHHHHHhcCCCCCHHHHHHHHhCC Confidence 67788888876434467888888999999999999878889999999999999999999999999999999999999998 Q sp|Q9BYF1|ACE2 577 KNMNVRPLLNYFEPLFTWLKDQNKNSF--VGWSTDWS 611 (805) Q Consensus 577 knmnvrpllnyfeplftwlkdqnknsf--vgwstdws 611 (805) ...+..+++.+|+++..||+.+|++.- +||..+|- T Consensus 563 d~~~~~~~~~~~~~l~~~l~~~~~~~~~~~g~~~~~~ 599 (612) T 2C6F_A 563 DALDAQPLLKYFQPVTQWLQEQNQQNGEVLGWPEYQW 599 (612) T ss_dssp SSCCSHHHHHHSHHHHHHHHHHHHHTTCCSSCSSTTC T ss_pred CCCCcHHHHHHHHHHHHHHHHHHHhcCCccCCCccCC Confidence 778889999999999999999988665 99997663 No 13 >5GIV_E Carboxypeptidase; M32 carboxypeptidase, Cobalt, Metallopeptidase, HYDROLASE; 2.4A {Deinococcus radiodurans str. R1} Probab=100.00 E-value=4.3e-52 Score=399.56 Aligned_cols=474 Identities=18% Similarity=0.185 Sum_probs=379.1 Template_Neff=9.400 Q sp|Q9BYF1|ACE2 19 STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQ 98 (805) Q Consensus 19 stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlq 98 (805) ++.+..+.+||.+.+.+...+-++.++++|++.|++++++.+.....- ++|++. ..+.+.+-.++-+|. T Consensus 3 ~~~~~~~~~~L~~~~~~~~~~~~~~~~~~Wd~~t~~p~~~~~~~~~~~----------~~l~~~-~~~~~~~~~~~~~l~ 71 (503) T 5GIV_E 3 TTRQDTQWQQLTEHWQELADFGGIEALLGWDQSTFLPAGAAEDRARQQ----------SLLAGL-RHARATDAGYGKLLD 71 (503) T ss_dssp ----CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHH----------HHHHHH-HHHHHSCHHHHHHHH T ss_pred ccchHHHHHHHHHHHHHHHHHhcHHHHHHHHHHcCCCcchHHHHHHHH----------HHHHHH-HHHhhcCHHHHHHHH Confidence 567788999999999999999999999999999999998876544333 233332 133455666777777 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG-KQLR 177 (805) Q Consensus 99 alqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg-kqlr 177 (805) .++.. +.++++. ..++..|..+|..++ .++|.+.++|+++.+..+ ++|..||.+.+ +.++ T Consensus 72 ~l~~~--~~l~~~~----~~~~~~~~~~~~~~~-----------~l~~~l~~~~~~~~~~~~--~~W~~~r~~~~~~~~~ 132 (503) T 5GIV_E 72 AASSR--SDLSPEQ----ARMVQVARQDFEKAT-----------RIPAEFVREFSGHVGQSY--SAWTEARPANDFGRMV 132 (503) T ss_dssp HHHTC--SSCCHHH----HHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHHHHHH--HHHHHHTTTTCHHHHH T ss_pred HHhcC--CCCCHHH----HHHHHHHHHHHHHhc-----------CCCHHHHHHHHhchhhHH--HHHHHHHHhCChhHhH Confidence 77655 2344433 344677888887765 467899999999998876 89999999977 8999 Q sp|Q9BYF1|ACE2 178 PLYEEYVVLKNEMARANHYE-DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYI 256 (805) Q Consensus 178 plyeeyvvlknemaranhye-dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyi 256 (805) |+|+++|-|+|+.|+.+.|+ ++.|||...|+- |...++++..|++|+|+|..||++||.+- T Consensus 133 ~~~~~~v~l~~~~A~~~g~~~~~yd~~l~~ye~----------~~~~~~l~~l~~~i~~~~~~l~~~v~~~~-------- 194 (503) T 5GIV_E 133 PYLEKTLDLSLQAASYFPEFGDPLDYYINESDE----------GMTAEQVGQVFAELRAALVPLADAVIAAG-------- 194 (503) T ss_dssp HHHHHHHHHHHHHHHTCTTCSSHHHHHHHHHST----------TCCHHHHHHHHHHHHHHHHHHHHHHHHHC-------- T ss_pred HHHHHHHHHHHHHHhhCCCCCCHHHHHHHhcCC----------CCCHHHHHHHHHHHHHHHHHHHHHHHHcC-------- Confidence 99999999999999999998 999999876653 44568899999999999999999999851 Q sp|Q9BYF1|ACE2 257 SPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDP 336 (805) Q Consensus 257 spigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdp 336 (805) .|+ | .+..+.++..++++.+++||.++|++... +. .| T Consensus 195 ~~~---~--------------------------------~~~~~~~~~~~~~~~~~~~~~~lG~~~~~------~~-~d- 231 (503) T 5GIV_E 195 APR---T--------------------------------DFLGRGFAQERQLAFGERVIRDYGYDFRR------GR-QD- 231 (503) T ss_dssp CCC---C--------------------------------GGGGSCCCHHHHHHHHHHHHHHHTCCGGG------CC-EE- T ss_pred CCC---c--------------------------------hhhcCCCCHHHHHHHHHHHHHHhCCCccc------Cc-cc- Confidence 010 1 12334455677889999999999998621 11 11 Q sp|Q9BYF1|ACE2 337 GNVQKAVCHPTAWDLGKGDFRILMCTKVT--MDDFLTAHHEMGHIQYDMAYAAQ--PFLLRNGANEGFHEAVGEIMSLSA 412 (805) Q Consensus 337 gnvqkavchptawdlgkgdfrilmctkvt--mddfltahhemghiqydmayaaq--pfllrnganegfheavgeimslsa 412 (805) ..|||.+|+++.+|+||.||.+++ ++|+.+.|||+||++|.+.+..+ +..++.+++.+|||+++..|.+.. T Consensus 232 -----~~~~~f~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~~~~~~~~~~~E~~s~~~E~~~ 306 (503) T 5GIV_E 232 -----LTHHPFMTRLGGHDVRITTRVKEQDPTDALYSTLHEAGHALYEQGVDAAFLGTPLGGGVSAGVHESQSRLWENLV 306 (503) T ss_dssp -----ECSSCCEEEEETTEEEEEECCCTTCHHHHHHHHHHHHHHHHHHHTSCTTTTTSTTSSCSCHHHHHHHHHCCCCCC T ss_pred -----cCCCccccCCCCCcEEEEeecCCCChHHHHHHHHHHHHHHHHHcCCCHHHcCCCCCCccchHHHHHHHHHHHHhh Confidence 599999999988999999999999 69999999999999999988764 345578899999999999999999 Q sp|Q9BYF1|ACE2 413 AT---------PKHLKSIGLLSPDF-QEDNETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWW 478 (805) Q Consensus 413 at---------pkhlksigllspdf-qednetein----fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkww 478 (805) .+ |++++.+|.+-.+. .++-...+| .+++.++.-+-.+|+.++..+|+|-+|.|+++.+++.+.|| T Consensus 307 ~~~~~f~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~g~~~~~~l~~~w~ 386 (503) T 5GIV_E 307 GRSRAFWAAYFGDWRDTFPEQLAGVTEEEMYRAVNTVSRSLIRTDADELTYNLHVITRFELEREMLAGKLAVRDLADAWH 386 (503) T ss_dssp TTSHHHHHHHHHHHHHHSTTTTTTCCHHHHHHHTTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHTTSSCGGGHHHHHH T ss_pred cCCHHHHHHHHHHHHHHCcHHhCCCCHHHHHHHHHhhCHHHhHHHhhhhhhcHHHHHHHHHHHHHhcCCCCHHHHHHHHH Confidence 99 99999988542222 222333444 45677777778888899999999999999999999999999 Q sp|Q9BYF1|ACE2 479 EMKREIVGVVEPVPHDETYCDPASLFHVSNDY---SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISN--STEAGQK 553 (805) Q Consensus 479 emkreivgvvepvphdetycdpaslfhvsndy---sfiryytrtlyqfqfqealcqaakhegplhkcdisn--steagqk 553 (805) ++.++..|+..|. +...|+ ...|++.++ .|++|....++++|+.+++|+... .+|+| +.+ ..++|.. T Consensus 387 ~~~~~y~G~~~~~--~~~~~~--~~~h~~~~~~~~y~~~Y~~g~i~a~ql~~~~~~~~~---~~~~~-~~~~~~~~~~~~ 458 (503) T 5GIV_E 387 AAYEQNLGLRAPS--DVDGAL--QDVHWYFGPIGGSFQGYTIGNVLSAQFYAAAEAANP---GLEAD-FARKDFSRLHGW 458 (503) T ss_dssp HHHHHHHSCCCSS--STTTTT--SCSGGGSSCSSSSSHHHHHHHHHHHHHHHHHHHHST---THHHH-HHTTCCHHHHHH T ss_pred HHHHHHhCCCCCC--CCCCCc--ccccccccCcccCCHHHHHHHHHHHHHHHHHHHhCC---ChHHH-hhcCChHHHHHH Confidence 9999999987553 334454 467888765 479999999999999999998764 49999 863 4688999 Q sp|Q9BYF1|ACE2 554 LF-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKD 597 (805) Q Consensus 554 lf-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkd 597 (805) |- ++++.|.+.||.-.++.+.|. .++..++++||+|+++||-+ T Consensus 459 l~~~il~~G~~~~~~ell~~~~g~-~ls~~~~l~y~~~~~~~~~~ 502 (503) T 5GIV_E 459 LRENVYRHGRRWTPGELIERATGQ-ALTAGPYLKYLRGKYGELYG 502 (503) T ss_dssp HCCCCCTTTTSSCHHHHHHHHHSS-SSCSHHHHHHHHHHHHHHHC T ss_pred HHHchHhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHHhc Confidence 94 999999999999999999996 89999999999999999864 No 14 >5GIV_F Carboxypeptidase; M32 carboxypeptidase, Cobalt, Metallopeptidase, HYDROLASE; 2.4A {Deinococcus radiodurans str. R1} Probab=100.00 E-value=4.3e-52 Score=399.56 Aligned_cols=474 Identities=18% Similarity=0.185 Sum_probs=381.7 Template_Neff=9.400 Q sp|Q9BYF1|ACE2 19 STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQ 98 (805) Q Consensus 19 stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlq 98 (805) ++.+..+.+||.+.+.+...+-++.++++|++.|++++++.+.....- ++|++. ..+.+.+-.++-+|. T Consensus 3 ~~~~~~~~~~L~~~~~~~~~~~~~~~~~~Wd~~t~~p~~~~~~~~~~~----------~~l~~~-~~~~~~~~~~~~~l~ 71 (503) T 5GIV_F 3 TTRQDTQWQQLTEHWQELADFGGIEALLGWDQSTFLPAGAAEDRARQQ----------SLLAGL-RHARATDAGYGKLLD 71 (503) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHH----------HHHHHH-HHHHHTCHHHHHHHH T ss_pred ccchHHHHHHHHHHHHHHHHHhcHHHHHHHHHHcCCCcchHHHHHHHH----------HHHHHH-HHHhhcCHHHHHHHH Confidence 567788999999999999999999999999999999998876544333 233332 133455666777777 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG-KQLR 177 (805) Q Consensus 99 alqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg-kqlr 177 (805) .++.. +.++++. ..++..|..+|..++ .++|.+.++|+++.+..+ ++|..||.+.+ +.++ T Consensus 72 ~l~~~--~~l~~~~----~~~~~~~~~~~~~~~-----------~l~~~l~~~~~~~~~~~~--~~W~~~r~~~~~~~~~ 132 (503) T 5GIV_F 72 AASSR--SDLSPEQ----ARMVQVARQDFEKAT-----------RIPAEFVREFSGHVGQSY--SAWTEARPANDFGRMV 132 (503) T ss_dssp HHHHC--SCCCHHH----HHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHHHHHH--HHHHHHTTTTCHHHHH T ss_pred HHhcC--CCCCHHH----HHHHHHHHHHHHHhc-----------CCCHHHHHHHHhchhhHH--HHHHHHHHhCChhHhH Confidence 77655 2344433 344677888887765 467899999999998876 89999999977 8999 Q sp|Q9BYF1|ACE2 178 PLYEEYVVLKNEMARANHYE-DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYI 256 (805) Q Consensus 178 plyeeyvvlknemaranhye-dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyi 256 (805) |+|+++|-|+|+.|+.+.|+ ++.|||...|+- |...++++..|++|+|+|..||++||.+- T Consensus 133 ~~~~~~v~l~~~~A~~~g~~~~~yd~~l~~ye~----------~~~~~~l~~l~~~i~~~~~~l~~~v~~~~-------- 194 (503) T 5GIV_F 133 PYLEKTLDLSLQAASYFPEFGDPLDYYINESDE----------GMTAEQVGQVFAELRAALVPLADAVIAAG-------- 194 (503) T ss_dssp HHHHHHHHHHHHHHHTCTTSSSHHHHHHHHHST----------TCCHHHHHHHHHHHHHHHHHHHHHHHHHC-------- T ss_pred HHHHHHHHHHHHHHhhCCCCCCHHHHHHHhcCC----------CCCHHHHHHHHHHHHHHHHHHHHHHHHcC-------- Confidence 99999999999999999998 999999876653 44568899999999999999999999851 Q sp|Q9BYF1|ACE2 257 SPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDP 336 (805) Q Consensus 257 spigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdp 336 (805) .|+ | .+..+.++..++++.+++||.++|++... +. .| T Consensus 195 ~~~---~--------------------------------~~~~~~~~~~~~~~~~~~~~~~lG~~~~~------~~-~d- 231 (503) T 5GIV_F 195 APR---T--------------------------------DFLGRGFAQERQLAFGERVIRDYGYDFRR------GR-QD- 231 (503) T ss_dssp CCC---C--------------------------------GGGGSCCCHHHHHHHHHHHHHHHTCCTTS------CC-EE- T ss_pred CCC---c--------------------------------hhhcCCCCHHHHHHHHHHHHHHhCCCccc------Cc-cc- Confidence 010 1 12334455677889999999999998621 11 11 Q sp|Q9BYF1|ACE2 337 GNVQKAVCHPTAWDLGKGDFRILMCTKVT--MDDFLTAHHEMGHIQYDMAYAAQ--PFLLRNGANEGFHEAVGEIMSLSA 412 (805) Q Consensus 337 gnvqkavchptawdlgkgdfrilmctkvt--mddfltahhemghiqydmayaaq--pfllrnganegfheavgeimslsa 412 (805) ..|||.+|+++.+|+||.||.+++ ++|+.+.|||+||++|.+.+..+ +..++.+++.+|||+++..|.+.. T Consensus 232 -----~~~~~f~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~~~~~~~~~~~E~~s~~~E~~~ 306 (503) T 5GIV_F 232 -----LTHHPFMTRLGGHDVRITTRVKEQDPTDALYSTLHEAGHALYEQGVDAAFLGTPLGGGVSAGVHESQSRLWENLV 306 (503) T ss_dssp -----ECSSCCEEEEETTEEEEEECCCTTCHHHHHHHHHHHHHHHHHHHHSCGGGTTSTTSSCSCHHHHHHHHHCCCCCC T ss_pred -----cCCCccccCCCCCcEEEEeecCCCChHHHHHHHHHHHHHHHHHcCCCHHHcCCCCCCccchHHHHHHHHHHHHhh Confidence 599999999988999999999999 69999999999999999988764 345578899999999999999999 Q sp|Q9BYF1|ACE2 413 AT---------PKHLKSIGLLSPDF-QEDNETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWW 478 (805) Q Consensus 413 at---------pkhlksigllspdf-qednetein----fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkww 478 (805) .+ |++++.+|.+-.+. .++-...+| .+++.++.-+-.+|+.++..+|+|-+|.|+++.+++.+.|| T Consensus 307 ~~~~~f~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~g~~~~~~l~~~w~ 386 (503) T 5GIV_F 307 GRSRAFWAAYFGDWRDTFPEQLAGVTEEEMYRAVNTVSRSLIRTDADELTYNLHVITRFELEREMLAGKLAVRDLADAWH 386 (503) T ss_dssp TTSHHHHHHHHHHHHHHSHHHHTTCCHHHHHHHTTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHTTSSCGGGHHHHHH T ss_pred cCCHHHHHHHHHHHHHHCcHHhCCCCHHHHHHHHHhhCHHHhHHHhhhhhhcHHHHHHHHHHHHHhcCCCCHHHHHHHHH Confidence 99 99999988542222 222333444 45677777778888899999999999999999999999999 Q sp|Q9BYF1|ACE2 479 EMKREIVGVVEPVPHDETYCDPASLFHVSNDY---SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISN--STEAGQK 553 (805) Q Consensus 479 emkreivgvvepvphdetycdpaslfhvsndy---sfiryytrtlyqfqfqealcqaakhegplhkcdisn--steagqk 553 (805) ++.++..|+..|. +...|+ ...|++.++ .|++|....++++|+.+++|+... .+|+| +.+ ..++|.. T Consensus 387 ~~~~~y~G~~~~~--~~~~~~--~~~h~~~~~~~~y~~~Y~~g~i~a~ql~~~~~~~~~---~~~~~-~~~~~~~~~~~~ 458 (503) T 5GIV_F 387 AAYEQNLGLRAPS--DVDGAL--QDVHWYFGPIGGSFQGYTIGNVLSAQFYAAAEAANP---GLEAD-FARKDFSRLHGW 458 (503) T ss_dssp HHHHHHHSCCCSS--STTTTT--SCSGGGSSCSSSSSHHHHHHHHHHHHHHHHHHHHST---THHHH-HHTTCCHHHHHH T ss_pred HHHHHHhCCCCCC--CCCCCc--ccccccccCcccCCHHHHHHHHHHHHHHHHHHHhCC---ChHHH-hhcCChHHHHHH Confidence 9999999987553 334454 467888765 479999999999999999998764 49999 863 4688999 Q sp|Q9BYF1|ACE2 554 LF-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKD 597 (805) Q Consensus 554 lf-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkd 597 (805) |- ++++.|.+.||.-.++.+.|. .++..++++||+|+++||-+ T Consensus 459 l~~~il~~G~~~~~~ell~~~~g~-~ls~~~~l~y~~~~~~~~~~ 502 (503) T 5GIV_F 459 LRENVYRHGRRWTPGELIERATGQ-ALTAGPYLKYLRGKYGELYG 502 (503) T ss_dssp HCCCCCTTTTSSCHHHHHHHHHSS-SCCSHHHHHHHHHHHHHHHC T ss_pred HHHchHhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHHhc Confidence 94 999999999999999999996 89999999999999999864 No 15 >3HQ2_B Bacillus subtilis M32 carboxypeptidase (E.C.3.4.24.-); Hydrolase, Metal-binding, Metalloprotease, Protease; HET: PO4; 2.9A {Bacillus subtilis} Probab=100.00 E-value=1.1e-47 Score=361.19 Aligned_cols=473 Identities=16% Similarity=0.152 Sum_probs=365.7 Template_Neff=10.100 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) ++-|++||.+++.++.++.+.+++++|+|.||+|+++.+........ |+.. -.+.+++-.++-+|+.++ T Consensus 3 ~~~a~~~L~~~~~~~~~~~~~~~~~~Wd~~T~~p~~~~~~~~~~~~~----------l~~~-~~~~~~~~~~~r~l~~l~ 71 (501) T 3HQ2_B 3 IHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRAESIGQ----------LSTD-IFNIQTSDRMKELIDVLY 71 (501) T ss_dssp -CHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTCCGGGHHHHHHHHHH----------HHHH-HHHHHHCHHHHHHHHHHH T ss_pred cchHHHHHHHHHHHHHhHHHHHHHHHHHHHhCCCCCChHHHHHHHHH----------HHHH-HHHHhcCHHHHHHHHHHH Confidence 45689999999999999999999999999999999887654433322 2222 234667788899999998 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG--KQLRPL 179 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg--kqlrpl 179 (805) ..|. .|+++.. ..++.|..+|+.++ |- .|.+-+.++++ .++|.++|+.||.. + +.++|+ T Consensus 72 ~~~~-~l~~~~~----~~~~~~~~~~~~~~-~~----------~~~~~~~~~~~--~~~r~~~w~~~~~~-~~~~~~~~~ 132 (501) T 3HQ2_B 72 ERFD-DLSEDTK----KAVELAKKEYEENK-KI----------PEAEYKEYVIL--CSKAETAWEEAKGK-SDFSLFSPY 132 (501) T ss_dssp HTGG-GSCHHHH----HHHHHHHHHHHHHH-TS----------CHHHHHHHHHH--HHHHHHHHHHHHHH-TCHHHHHHH T ss_pred Hccc-CCCHHHH----HHHHHHHHHHHHcc-CC----------CHHHHHHHHHH--HHHHHHHHHHHHhc-CCHHHhHHH Confidence 8775 4665542 25788888898764 32 24444455544 45999999999986 6 789999 Q sp|Q9BYF1|ACE2 180 YEEYVVLKNEMARANHYED-YGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISP 258 (805) Q Consensus 180 yeeyvvlknemaranhyed-ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp 258 (805) +.++|-+++++|+.+.|++ ..|+|...|+- +.-.++++..|++|+|.|..+|+++|.|... T Consensus 133 l~~lv~l~~~~A~~~Gy~~~~~~~~~~~~~~----------~~~~~~l~~l~~~l~~~~~~l~~~~~~~~~~-------- 194 (501) T 3HQ2_B 133 LEQLIEFNKRFITYWGYQEHPYDALLDLFEP----------GVTVKVLDQLFAELKEAIIPLVKQVTASGNK-------- 194 (501) T ss_dssp HHHHHHHHHHHHHHHCCSSCTTHHHHTTTST----------TCCHHHHHHHHHHHHHHHHHHHHHHHSCSCC-------- T ss_pred HHHHHHHHHHHHHHccCCCChHHHHHHhhCC----------CCCHHHHHHHHHHHHHHHHHHHHHHHHcCCC-------- Confidence 9999999999999999995 49999887762 2335789999999999999999999986310 Q sp|Q9BYF1|ACE2 259 IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGN 338 (805) Q Consensus 259 igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgn 338 (805) | | +.+..+.+...++++.++.+|.+.|++.. .| T Consensus 195 ----p-----------~-------------------~~~~~~~~~~~~~~~~~~~~~~~~G~~~~-~~------------ 227 (501) T 3HQ2_B 195 ----P-----------D-------------------TSFITKAFPKEKQKELSLYFLQELGYDFD-GG------------ 227 (501) T ss_dssp ----C-----------C-------------------CTTTTSCCCHHHHHHHHHHHHHHHTCCGG-GC------------ T ss_pred ----C-----------C-------------------cchhcCcCCHHHHHHHHHHHHHHhCCCCC-CC------------ Confidence 1 0 11233445556678889999999998752 11 Q sp|Q9BYF1|ACE2 339 VQKAVCHPTAWDLGKGDFRILMCTK--VTMDDFLTAHHEMGHIQYDMAYA-AQPF-LLRNGANEGFHEAVGEIMSLS-AA 413 (805) Q Consensus 339 vqkavchptawdlgkgdfrilmctk--vtmddfltahhemghiqydmaya-aqpf-llrnganegfheavgeimsls-aa 413 (805) .....|||.+|+++.+|+||.+|.. ..++|+.+.|||+||++|.+.+. .+|+ .++.+++.+|||+++..|.+. +. T Consensus 228 r~~k~~~~~~~~~~~~d~ri~~~~~~~~~~~~~~tl~HE~GHa~~~~~~~~~~~~~~~~~~~~~~~~E~~s~~~E~~~~~ 307 (501) T 3HQ2_B 228 RLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNIDEALSGTNLSDGASMGIHESQSLFYENFIGR 307 (501) T ss_dssp CEEECSSCCEEEEETTEEEEEECCCTTCHHHHHHHHHHHHHHHHHHTTSCGGGTTSTTCSCSCHHHHHHHHHHHCCCCCT T ss_pred CCCCCCCceeecCCCCceEEEEecChhhHHHHHHHHHHHHHHHHHHcCCCHHHCCCCccccccchhHHHHHHHHHHHhcC Confidence 1236899999999889999998877 56788999999999999999887 4887 789999999999999999988 66 Q sp|Q9BYF1|ACE2 414 TPKHLKSIGL-LSPDFQE--------DNETEINF----LLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM 480 (805) Q Consensus 414 tpkhlksigl-lspdfqe--------dneteinf----llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwem 480 (805) .+.+++.+.. ++..|.+ +-...+|. +.++++..+..+++......|+|-+|.|+++.+++.+.||++ T Consensus 308 ~~~~l~~~~~~~~~~~~~~l~~~~~~~l~~~l~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~~~~~~~~l~~~w~~~ 387 (501) T 3HQ2_B 308 NKHFWTPYYKKIQEASPVQFKDISLDDFVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQK 387 (501) T ss_dssp SGGGHHHHHHHHHHHSHHHHTTCCHHHHHHHHTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHTTTCCCGGGHHHHHHHH T ss_pred CHHHHHHHHHHHHHHCCccccCCCHHHHHHHHHhcCCCcchhHhHhhhHhHHHHHHHHHHHHHHcCCCCHhhHHHHHHHH Confidence 6666654422 2211111 11222332 333444445556666666799999999999889999999999 Q sp|Q9BYF1|ACE2 481 KREIVGVVEPVPHDETYCDPASLFHVSNDY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDI-SNSTEAGQKL-FN 556 (805) Q Consensus 481 kreivgvvepvphdetycdpaslfhvsndy--sfiryytrtlyqfqfqealcqaakhegplhkcdi-snsteagqkl-fn 556 (805) ..+..|+..|. + ..++.+..|++.+| .+++|....++++|+.+++|+... .+|.|+. .+..++|++| -+ T Consensus 388 ~~~y~g~~~~~--~--~~~~~~~~H~~~~~~~yy~~Y~~~~i~a~ql~~~~~~~~~---~~~~~~~~~~~~~~~~~l~~~ 460 (501) T 3HQ2_B 388 YQDYLGITPQT--D--AEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLP---EFDALLERGEFHPIKQWLTEK 460 (501) T ss_dssp HHHHHSCCCCS--T--TTTGGGCSTTTTTCTTCTHHHHHHHHHHHHHHHHHHHHCT---THHHHHHTTCCHHHHHHHHHH T ss_pred HHHHhCCCCCC--C--CCcchhccccccccccCchHHHHHHHHHHHHHHHHHHhCc---cHHHHHHcCCchHHHHHHHHc Confidence 99999986553 2 26778889998764 488999999999999999998765 4899987 4566999999 49 Q sp|Q9BYF1|ACE2 557 MLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKD 597 (805) Q Consensus 557 mlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkd 597 (805) +|..|.+.||.-.++.+.|. .+++++++.||+|+++|+.+ T Consensus 461 ~l~~G~s~~~~e~l~~~~G~-~l~~~~~l~~~~~~~~~~~~ 500 (501) T 3HQ2_B 461 VHIHGKRKKPLDIIKDATGE-ELNVRYLIDYLSNKYSNLYL 500 (501) T ss_dssp TGGGTTSSCHHHHHHHHHSS-CCCTHHHHHHHHHHHHHTTC T ss_pred ccccccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHHhc Confidence 99999999999999999998 89999999999999999864 No 16 >1K9X_B m32 carboxypeptidase; HEXXH motif, M32 family, metallopeptidase; 2.3A {Pyrococcus furiosus} SCOP: d.92.1.5 Probab=100.00 E-value=1.1e-46 Score=357.76 Aligned_cols=470 Identities=16% Similarity=0.193 Sum_probs=361.6 Template_Neff=9.800 Q sp|Q9BYF1|ACE2 20 TIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQA 99 (805) Q Consensus 20 tieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqa 99 (805) ..|+++.++|++++++...+.+++++++|+++||+++.+.+...++...++.++. +.+.+-.++-+|.. T Consensus 4 ~~~~~~~~~l~~~~~~~~~~~~~~~~~~wd~~t~~~~~~~~~~~~~~~~l~~~~~-----------~~~~~~~~~~~l~~ 72 (499) T 1K9X_B 4 VFQNETIKQILAKYRRIWAIGHAQSVLGWDLEVNMPKEGILERSVAQGELSVLSH-----------ELLLHPEFVNLVEK 72 (499) T ss_dssp CCCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHHHHHHHHHH-----------HHHTCHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCChhHHHHHHHHHHHHHHHHH-----------HHhhCHHHHHHHHH Confidence 3578899999999999999999999999999999999998887776666655544 35567778888888 Q sp|Q9BYF1|ACE2 100 LQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG--KQLR 177 (805) Q Consensus 100 lqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg--kqlr 177 (805) +++. +.+++. ...+++.|..+|..+. .+.|.+.++++++. ++|.++|+.||.. + +.++ T Consensus 73 ~~~~--~~l~~~----~~~~~~~~~~~~~~~~-----------~l~~~l~~~~~~~~--~~~~~~w~~~~~~-~~~~~~~ 132 (499) T 1K9X_B 73 AKGL--ENLNEY----ERGIVRVLDRSIRIAR-----------AFPPEFIREVSETT--SLATKAWEEAKAK-DDFSKFE 132 (499) T ss_dssp HHHC--SSCCHH----HHHHHHHHHHHHHHHT-----------SSCHHHHHHHHHHH--HHHHHHHHHHHHT-TCGGGTH T ss_pred Hhcc--CCCCHH----HHHHHHHHHHHHHHHh-----------cCCHHHHHHHHHHH--HHHHHHHHHHHHc-CChHHhH Confidence 7765 344432 2346788888888764 46688999998875 6899999999984 7 8999 Q sp|Q9BYF1|ACE2 178 PLYEEYVVLKNEMARANHYED-YGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYI 256 (805) Q Consensus 178 plyeeyvvlknemaranhyed-ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyi 256 (805) |+++++|-++++.|+.+.|++ +.|||...|+- +...++++..|++|+|+|..||++++.+. . T Consensus 133 ~~l~~lv~l~~~~A~~~G~~~s~~d~~~~~~~~----------~~~~~~l~~l~~~l~~~~~~l~~~~~~~~--~----- 195 (499) T 1K9X_B 133 PWLDKIISLAKRAAEYLGYEEEPYDALLDLYEE----------GLRTRDVEKMFEVLEKKLKPLLDKILEEG--K----- 195 (499) T ss_dssp HHHHHHHHHHHHHHHHHCCSSCHHHHHHHHHST----------TCCHHHHHHHHHHCCCCCHHHHHHHHHHC--S----- T ss_pred HHHHHHHHHHHHHHHHcCCCCCHHHHHHHHhcC----------CCCHHHHHHHHHHHHHHHHHHHHHHHhcC--C----- Confidence 999999999999999999995 99999776653 34568999999999999999999999852 0 Q sp|Q9BYF1|ACE2 257 SPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDP 336 (805) Q Consensus 257 spigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdp 336 (805) .|+ +.|+. .+-++..++++.+++||.++|++.++.|.. T Consensus 196 -----~~~-----------------~~p~~------------~~~~~~~~~~~~~~~~~~~lG~~~~~~~r~-------- 233 (499) T 1K9X_B 196 -----VPR-----------------EHPLE------------KEKYEREWMERVNLWILQKFGFPLGTRARL-------- 233 (499) T ss_dssp -----SCS-----------------CCGGG------------TCBCCHHHHHHHHHHHHHHHTCCBTTTEEE-------- T ss_pred -----CCC-----------------CCccc------------cccCCHHHHHHHHHHHHHHhCCCcccCCcc-------- Confidence 121 11221 122233457788999999999998853321 Q sp|Q9BYF1|ACE2 337 GNVQKAVCHPTAWDLGKGDFRILMCTKVT--MDDFLTAHHEMGHIQYDMAYAA-QPFL-LRNGANEGFHEAVGEIMSLSA 412 (805) Q Consensus 337 gnvqkavchptawdlgkgdfrilmctkvt--mddfltahhemghiqydmayaa-qpfl-lrnganegfheavgeimslsa 412 (805) .-.|||.+|+++.+|+||.+|...+ ++|+.+.||||||+.|.+.+.. +|.+ ++.+++.+|||+++..|.... T Consensus 234 ----dk~~~~~~~~~~~~d~rI~~~~~~~~~~~~~~tl~HE~GHa~y~~~~~~~~~~~~~~~~~~~~~~E~~S~~~E~~~ 309 (499) T 1K9X_B 234 ----DVSAHPFTTEFGIRDVRITTRYEGYDFRRTILSTVHEFGHALYELQQDERFMFTPIAGGVSLGIHESQSRFWENII 309 (499) T ss_dssp ----EECSSCCEEEEETTEEEEEECCCSBCTHHHHHHHHHHHHHHHHHHTSCGGGTTSTTSSCSCHHHHHHHHHCCCCCC T ss_pred ----ccCCCCeeecCCcccEEEEeeecCccHHHHHHHHHHHHHHHHHHccCCccccCCcccccccchhHHHHHHHHHHHh Confidence 1589999999998999999999886 7899999999999999998875 5543 578899999999999998655 Q sp|Q9BYF1|ACE2 413 ATP----KHLKSIGLLSPDFQ-------EDNETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKW 477 (805) Q Consensus 413 atp----khlksigllspdfq-------ednetein----fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkw 477 (805) ..+ +++.. .++..+. ++-...++ .+++.++..+..++...+.-.|+|.+|.|+++.+++.+.| T Consensus 310 ~~~~~~~~~l~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~~~~~~~~l~~~w 387 (499) T 1K9X_B 310 GRSKEFVELIYP--VLKENLPFMSNYTPEDVYLYFNIVRPDFIRTEADVVTYNFHILLRFKLERLMVSEEIKAKDLPEMW 387 (499) T ss_dssp TTSHHHHHHHHH--HHHHHCGGGGGCCHHHHHHHHTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHHSCCCGGGHHHHH T ss_pred cCCHHHHHHHHH--HHHHHCCCCCCCCHHHHHHHHhccCccccccccchhhHhHHHHHHHHHHHHHhcCCCCHHHhhHHH Confidence 433 33321 1222121 11112222 1222222233333334445678999999999999999999 Q sp|Q9BYF1|ACE2 478 WEMKREIVGVVEPVPHDETYCDPASLFHVSNDY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDI-SNSTEAGQKL 554 (805) Q Consensus 478 wemkreivgvvepvphdetycdpaslfhvsndy--sfiryytrtlyqfqfqealcqaakhegplhkcdi-snsteagqkl 554 (805) |++..+..|+..|. +. .+.....|++.++ .|++|....++++|+.+++|+.. |+++.|.. ....++|++| T Consensus 388 ~~~~~~y~G~~~~~--~~--~~~~~~~H~~~~~~~yy~~Y~~~~i~a~ql~~~~~~~~---~~~~~~~~~~~~~~~g~~l 460 (499) T 1K9X_B 388 NDEMERLLGIRPRK--YS--EGILQDIHWAHGSIGYFPTYTIGTLLSAQLYYHIKKDI---PDFEEKVAKAEFDPIKAWL 460 (499) T ss_dssp HHHHHHHHSCCCSS--GG--GTTTSCSHHHHTCCSCTHHHHHHHHHHHHHHHHHTTTC---TTHHHHHHHTCCHHHHHHH T ss_pred HHHHHHHhCCCCCC--CC--CcchhhccccccccccchHHHHHHHHHHHHHHHHHHHC---CcHHHHHHcCCcHHHHHHH Confidence 99999999987543 22 4667888988766 67899999999999999999875 36777744 3447899999 Q sp|Q9BYF1|ACE2 555 F-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFT 593 (805) Q Consensus 555 f-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplft 593 (805) . ++++.|.+.||.-.++.+.|. .++..|+++||+|++. T Consensus 461 ~~~~l~~G~~~~~~e~l~~~~G~-~l~~~~ll~~~~~~~~ 499 (499) T 1K9X_B 461 REKIHRWGSIYPPKELLKKAIGE-DMDAEYFVRWVKEKYL 499 (499) T ss_dssp HHHTGGGTTSSCHHHHHHHHHSS-CCCTHHHHHHHHHHHC T ss_pred HHcchhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHhC Confidence 5 999999999999999999999 7999999999999873 No 17 >1KA2_A M32 carboxypeptidase; HEXXH motif, M32 family, metallopeptidase; 2.2A {Pyrococcus furiosus} SCOP: d.92.1.5 Probab=100.00 E-value=1.1e-46 Score=357.76 Aligned_cols=470 Identities=16% Similarity=0.193 Sum_probs=361.6 Template_Neff=9.800 Q sp|Q9BYF1|ACE2 20 TIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQA 99 (805) Q Consensus 20 tieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqa 99 (805) ..|+++.++|++++++...+.+++++++|+++||+++.+.+...++...++.++. +.+.+-.++-+|.. T Consensus 4 ~~~~~~~~~l~~~~~~~~~~~~~~~~~~wd~~t~~~~~~~~~~~~~~~~l~~~~~-----------~~~~~~~~~~~l~~ 72 (499) T 1KA2_A 4 VFQNETIKQILAKYRRIWAIGHAQSVLGWDLEVNMPKEGILERSVAQGELSVLSH-----------ELLLHPEFVNLVEK 72 (499) T ss_dssp CSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHHHHHHHHHH-----------HHHTCHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCChhHHHHHHHHHHHHHHHHH-----------HHhhCHHHHHHHHH Confidence 3578899999999999999999999999999999999998887776666655544 35567778888888 Q sp|Q9BYF1|ACE2 100 LQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG--KQLR 177 (805) Q Consensus 100 lqqngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg--kqlr 177 (805) +++. +.+++. ...+++.|..+|..+. .+.|.+.++++++. ++|.++|+.||.. + +.++ T Consensus 73 ~~~~--~~l~~~----~~~~~~~~~~~~~~~~-----------~l~~~l~~~~~~~~--~~~~~~w~~~~~~-~~~~~~~ 132 (499) T 1KA2_A 73 AKGL--ENLNEY----ERGIVRVLDRSIRIAR-----------AFPPEFIREVSETT--SLATKAWEEAKAK-DDFSKFE 132 (499) T ss_dssp HHTC--SSCCHH----HHHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHH--HHHHHHHHHHHHT-TCGGGTH T ss_pred Hhcc--CCCCHH----HHHHHHHHHHHHHHHh-----------cCCHHHHHHHHHHH--HHHHHHHHHHHHc-CChHHhH Confidence 7765 344432 2346788888888764 46688999998875 6899999999984 7 8999 Q sp|Q9BYF1|ACE2 178 PLYEEYVVLKNEMARANHYED-YGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYI 256 (805) Q Consensus 178 plyeeyvvlknemaranhyed-ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyi 256 (805) |+++++|-++++.|+.+.|++ +.|||...|+- +...++++..|++|+|+|..||++++.+. . T Consensus 133 ~~l~~lv~l~~~~A~~~G~~~s~~d~~~~~~~~----------~~~~~~l~~l~~~l~~~~~~l~~~~~~~~--~----- 195 (499) T 1KA2_A 133 PWLDKIISLAKRAAEYLGYEEEPYDALLDLYEE----------GLRTRDVEKMFEVLEKKLKPLLDKILEEG--K----- 195 (499) T ss_dssp HHHHHHHHHHHHHHHHHCCSSCHHHHHHHHHST----------TCCHHHHHHHHHHHHHHHHHHHHHHHHTT--C----- T ss_pred HHHHHHHHHHHHHHHHcCCCCCHHHHHHHHhcC----------CCCHHHHHHHHHHHHHHHHHHHHHHHhcC--C----- Confidence 999999999999999999995 99999776653 34568999999999999999999999852 0 Q sp|Q9BYF1|ACE2 257 SPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDP 336 (805) Q Consensus 257 spigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdp 336 (805) .|+ +.|+. .+-++..++++.+++||.++|++.++.|.. T Consensus 196 -----~~~-----------------~~p~~------------~~~~~~~~~~~~~~~~~~~lG~~~~~~~r~-------- 233 (499) T 1KA2_A 196 -----VPR-----------------EHPLE------------KEKYEREWMERVNLWILQKFGFPLGTRARL-------- 233 (499) T ss_dssp -----SCS-----------------CCGGG------------TCBCCHHHHHHHHHHHHHHHTCCBTTTEEE-------- T ss_pred -----CCC-----------------CCccc------------cccCCHHHHHHHHHHHHHHhCCCcccCCcc-------- Confidence 121 11221 122233457788999999999998853321 Q sp|Q9BYF1|ACE2 337 GNVQKAVCHPTAWDLGKGDFRILMCTKVT--MDDFLTAHHEMGHIQYDMAYAA-QPFL-LRNGANEGFHEAVGEIMSLSA 412 (805) Q Consensus 337 gnvqkavchptawdlgkgdfrilmctkvt--mddfltahhemghiqydmayaa-qpfl-lrnganegfheavgeimslsa 412 (805) .-.|||.+|+++.+|+||.+|...+ ++|+.+.||||||+.|.+.+.. +|.+ ++.+++.+|||+++..|.... T Consensus 234 ----dk~~~~~~~~~~~~d~rI~~~~~~~~~~~~~~tl~HE~GHa~y~~~~~~~~~~~~~~~~~~~~~~E~~S~~~E~~~ 309 (499) T 1KA2_A 234 ----DVSAHPFTTEFGIRDVRITTRYEGYDFRRTILSTVHEFGHALYELQQDERFMFTPIAGGVSLGIHESQSRFWENII 309 (499) T ss_dssp ----EECSSCCEEEEETTEEEEEECCCSBCTHHHHHHHHHHHHHHHHHHTCCGGGTTSTTSSCCCHHHHHHHHHCCCCCC T ss_pred ----ccCCCCeeecCCcccEEEEeeecCccHHHHHHHHHHHHHHHHHHccCCccccCCcccccccchhHHHHHHHHHHHh Confidence 1589999999998999999999886 7899999999999999998875 5543 578899999999999998655 Q sp|Q9BYF1|ACE2 413 ATP----KHLKSIGLLSPDFQ-------EDNETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKW 477 (805) Q Consensus 413 atp----khlksigllspdfq-------ednetein----fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkw 477 (805) ..+ +++.. .++..+. ++-...++ .+++.++..+..++...+.-.|+|.+|.|+++.+++.+.| T Consensus 310 ~~~~~~~~~l~~--~~~~~~~~~~~~~~~~l~~~l~~~~~~l~r~~~~~l~~~~~~~~~~~~e~~l~~~~~~~~~l~~~w 387 (499) T 1KA2_A 310 GRSKEFVELIYP--VLKENLPFMSNYTPEDVYLYFNIVRPDFIRTEADVVTYNFHILLRFKLERLMVSEEIKAKDLPEMW 387 (499) T ss_dssp TTSHHHHHHHHH--HHHHHCGGGGGCCHHHHHHHHTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHHSCCCGGGHHHHH T ss_pred cCCHHHHHHHHH--HHHHHCCCCCCCCHHHHHHHHhccCccccccccchhhHhHHHHHHHHHHHHHhcCCCCHHHhhHHH Confidence 433 33321 1222121 11112222 1222222233333334445678999999999999999999 Q sp|Q9BYF1|ACE2 478 WEMKREIVGVVEPVPHDETYCDPASLFHVSNDY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDI-SNSTEAGQKL 554 (805) Q Consensus 478 wemkreivgvvepvphdetycdpaslfhvsndy--sfiryytrtlyqfqfqealcqaakhegplhkcdi-snsteagqkl 554 (805) |++..+..|+..|. +. .+.....|++.++ .|++|....++++|+.+++|+.. |+++.|.. ....++|++| T Consensus 388 ~~~~~~y~G~~~~~--~~--~~~~~~~H~~~~~~~yy~~Y~~~~i~a~ql~~~~~~~~---~~~~~~~~~~~~~~~g~~l 460 (499) T 1KA2_A 388 NDEMERLLGIRPRK--YS--EGILQDIHWAHGSIGYFPTYTIGTLLSAQLYYHIKKDI---PDFEEKVAKAEFDPIKAWL 460 (499) T ss_dssp HHHHHHHHSCCCSS--GG--GTTTSCSHHHHTCTTCTHHHHHHHHHHHHHHHHHHHHC---TTHHHHHHHTCCHHHHHHH T ss_pred HHHHHHHhCCCCCC--CC--CcchhhccccccccccchHHHHHHHHHHHHHHHHHHHC---CcHHHHHHcCCcHHHHHHH Confidence 99999999987543 22 4667888988766 67899999999999999999875 36777744 3447899999 Q sp|Q9BYF1|ACE2 555 F-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFT 593 (805) Q Consensus 555 f-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplft 593 (805) . ++++.|.+.||.-.++.+.|. .++..|+++||+|++. T Consensus 461 ~~~~l~~G~~~~~~e~l~~~~G~-~l~~~~ll~~~~~~~~ 499 (499) T 1KA2_A 461 REKIHRWGSIYPPKELLKKAIGE-DMDAEYFVRWVKEKYL 499 (499) T ss_dssp HHHTGGGTTSSCHHHHHHHHHSS-CCCTHHHHHHHHHHHC T ss_pred HHcchhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHhC Confidence 5 999999999999999999999 7999999999999873 No 18 >5E3X_A Thermostable carboxypeptidase 1; Carboxypeptidase, Fervidobacterium, FisCP, HYDROLASE; 2.197A {Fervidobacterium islandicum} Probab=100.00 E-value=2.4e-46 Score=356.74 Aligned_cols=456 Identities=17% Similarity=0.229 Sum_probs=345.9 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 27 TFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSS 106 (805) Q Consensus 27 tfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalqqngss 106 (805) .||+.++.+++.+.++.++++|+|.||+++++.+.+..+...++.+ ..+.+++-+++-||+.++.. T Consensus 2 ~~l~~~~~~~~~~~~~~~~~~Wd~~t~~~~~~~~~r~~~~~~l~~~-----------~~~~~~~~~~~~~l~~~~~~--- 67 (489) T 5E3X_A 2 EELKSYYKRVAKYYSAAALLYWDMQTYMPKDAGPYRAEVLSEIGTY-----------AFKQITDDALGKLLETAQPQ--- 67 (489) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHHHHHHHH-----------HHHHHTSHHHHHHHHHCCCC--- T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHhcCCCCchHHHHHHHHHHHHH-----------HHHHhcCHHHHHHHHHhCCC--- Confidence 4889999999999999999999999999999998766665555543 33457788899999888752 Q sp|Q9BYF1|ACE2 107 VLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG--KQLRPLYEEYV 184 (805) Q Consensus 107 vlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg--kqlrplyeeyv 184 (805) +.+...++..|..+|++++++ .|.+-++++++.+..+ ++|..||.. + +.++|.|+++| T Consensus 68 ------~~~~~~~~~~~~~~~~~~~~~-----------~~~l~~~~~~~~~~~~--~~W~~~r~~-~~~~~~~~~~~~~v 127 (489) T 5E3X_A 68 ------SEIDEKLVYVGKKEYYKYKKV-----------PPELFQEIMITSTMLE--QKWEIAKPR-GDFEEVRPLLEKIV 127 (489) T ss_dssp ------SHHHHHHHHHHHHHHHHHHTS-----------CHHHHHHHHHHHHHHH--HHHHHHGGG-TCSTTTHHHHHHHH T ss_pred ------CHHHHHHHHHHHHHHHhccCC-----------CHHHHHHHHHhhhHHH--HHHHHHHhc-CCHHHHHHHHHHHH Confidence 234667788999999998763 4667788888888776 999999996 8 89999999999 Q sp|Q9BYF1|ACE2 185 VLKNEMARANHYED-YGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLP 263 (805) Q Consensus 185 vlknemaranhyed-ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyispigclp 263 (805) -+.|++|+.+.|++ .+++|...|+-. + ..++++..|++| +.+||..|.+.|+.. | T Consensus 128 ~l~~~~A~~~g~~~~~y~~~~~~y~~~----~------~~~~l~~~~~~l-------~~~v~~~l~~~~~~~-------~ 183 (489) T 5E3X_A 128 DLSRKYADILGYEGEPYNALLDLYEPG----M------KAEEVDQIFSKV-------RDFIVEVLEKIERLP-------K 183 (489) T ss_dssp HHHHHHHHTTCCSSCHHHHHHHHHSTT----C------CHHHHHHHHHHH-------HHHHHHHHHHHHHSC-------C T ss_pred HHHHHHHHHhCCCCChHHHHHHHhCCC----C------CHHHHHHHHHHH-------HHHHHHHHHHHhcCC-------C Confidence 99999999999987 568887766542 1 124455555554 556888887777431 3 Q sp|Q9BYF1|ACE2 264 AHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAV 343 (805) Q Consensus 264 ahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwensmltdpgnvqkav 343 (805) +| +.++.|+.. + .++.+. +.++.+.|... ++|... .. T Consensus 184 ~~-------------~~~~~~~~~----~-----------~~~~~~--~~~~~~~g~d~------------~~~~~~-~~ 220 (489) T 5E3X_A 184 SE-------------DPFNREIGV----D-----------KQKEFS--NWLLHYLKYDF------------TKGRLD-VS 220 (489) T ss_dssp CC-------------CTTCSCCCH----H-----------HHHHHH--HHHHHHTTCCT------------TSCCEE-EC T ss_pred CC-------------CcccCCCCH----H-----------HHHHHH--HHHHHHcCCCC------------CCCCee-cc Confidence 32 223333321 1 122222 45667777665 122221 38 Q sp|Q9BYF1|ACE2 344 CHPTAWDLGKGDFRILMCT--KVTMDDFLTAHHEMGHIQYDMAYAAQ--PFLLRNGANEGFHEAVGEIMSLSAAT----- 414 (805) Q Consensus 344 chptawdlgkgdfrilmct--kvtmddfltahhemghiqydmayaaq--pfllrnganegfheavgeimslsaat----- 414 (805) |||..++++.+|+||.+|. +++++|+.+.|||+||++|.+.+..+ ...++.+++.+|||+++..|.+.... T Consensus 221 ~~~~~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~~~~~~~~~~~E~~s~~~E~~~~~~l~~~ 300 (489) T 5E3X_A 221 AHPFTNPIGLNDVRITTRYIVNDIRNSIYSTIHEFGHALYALSIPTEFYGLPIGSSASYGFDESQSRFWENVVGRSLAFW 300 (489) T ss_dssp SSCCEEEEETTEEEEEECCCTTCHHHHHHHHHHHHHHHHHHHHSCGGGTTSGGGSCSCHHHHHHHHHCCCCCCTTSHHHH T ss_pred CCCccCCCCCCceEEeeeccccchhHHHHHHHHHHHHHHHHcCCChHHcCCCCccccCcccchhHHHHHHHHhhcCHHHH Confidence 9999999988999999999 99999999999999999999988752 22236789999999999999887776 Q sp|Q9BYF1|ACE2 415 ----PKHLKSIGLLSPDFQEDNETEINFLLKQALT-IVGT-------LPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKR 482 (805) Q Consensus 415 ----pkhlksigllspdfqedneteinfllkqalt-ivgt-------lpftymlekwrwmvfkgeipkdqwmkkwwemkr 482 (805) |+|++.+|++. +.. ..++...+.++.. ...+ ++...+...|+|.++.|+++.+++-+.||+... T Consensus 301 ~~~~~~~~~~l~~~~-~~~---~~~~~~~l~~~~~~~~~~~~d~l~~~~~~~~~~~~e~~~~~g~~~~~~l~~~w~~~~~ 376 (489) T 5E3X_A 301 KGIYSKFIEIVPEMR-GYS---VEELWRAVNRVQRSFIRTEADEVTYNLHIIIRFEIERELINGELSVKDVPDKWNELYK 376 (489) T ss_dssp HHHHHHHHHHCGGGT-TSC---HHHHHHHTSCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHTTSSCGGGHHHHHHHHHH T ss_pred HHHHHHHHHHchhhc-CCC---HHHHHHHHHHHccccchhHhHHHHHHHHHHHHHHHHHHHHhCCCCHhhhhHHHHHHHH Confidence 77878887651 221 1122222222211 1121 244567799999999999999999999999999 Q sp|Q9BYF1|ACE2 483 EIVGVVEPVPHDETYCDPASLFHVSN-DY-SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDIS-NS-TEAGQKLF-NM 557 (805) Q Consensus 483 eivgvvepvphdetycdpaslfhvsn-dy-sfiryytrtlyqfqfqealcqaakhegplhkcdis-ns-teagqklf-nm 557 (805) +..|+..|. + ..++....|+.. .| .+++|....++++|+.+++|+.. +++.| +. ++ .++|+.|- ++ T Consensus 377 ~y~g~~~~~--~--~~~~~~~~h~~~~~~~y~~~Y~~~~i~a~ql~~~~~~~~----~~~~~-~~~~~~~~~g~~l~~~~ 447 (489) T 5E3X_A 377 KYLGLDVPN--N--TLGCMQDPHWFGGNFGYFPTYALGNLYAAQIFEKLKEEI----NFEEV-VSAGNFEIIKNFLKEKI 447 (489) T ss_dssp HHHCCCCCS--T--TTTTTSCSGGGGTCCSCTHHHHHHHHHHHHHHHHHHHHS----CHHHH-HHHTCTHHHHHHHHHHT T ss_pred HHhCCCCCC--C--CCCCCCCCcccccccchhHHHHHHHHHHHHHHHHHHHcC----CHHHH-HhcCCHHHHHHHHHHch Confidence 999975443 2 235667788875 67 89999999999999999999865 69999 54 55 57899998 59 Q sp|Q9BYF1|ACE2 558 LRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKD 597 (805) Q Consensus 558 lrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkd 597 (805) +..|.+.||.-.++++.|. .+++++++.||+|++.|+.. T Consensus 448 l~~G~~~~~~e~l~~~~G~-~ls~~~~l~~~~~~~~~~~~ 486 (489) T 5E3X_A 448 HSKGKMYEPSDLIKIVTGK-PLSYESFVRYIKDKYSKVYE 486 (489) T ss_dssp GGGTTSSCHHHHHHHHHSS-CCCSHHHHHHHHHHHHHHHT T ss_pred hhcCcCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHHhc Confidence 9999999999999999998 89999999999999999974 No 19 >3HOA_A Thermostable carboxypeptidase 1 (E.C.3.4.17.19); proline-rich loop, Carboxypeptidase, Hydrolase; 2.1A {Thermus thermophilus HB27} Probab=100.00 E-value=1.1e-45 Score=356.95 Aligned_cols=468 Identities=19% Similarity=0.228 Sum_probs=373.5 Template_Neff=9.300 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) ++++..||++++.+...+-+..++++|++.|++++.+.+..... .++|+.. -.+.+.+-.++-+|..++ T Consensus 3 ~~~~~~~l~~~~~~~~~~~~~~~~~~Wd~~t~~p~~~~~~r~~~----------~~~l~~~-~~~~~~~~~~~~~l~~~~ 71 (509) T 3HOA_A 3 PEAAYQNLLEFQRETAYLASLGALAAWDQRTMIPKKGHEHRARQ----------MAALARL-LHQRMTDPRIGEWLEKVE 71 (509) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHH----------HHHHHHH-HHHHHTCHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhCCCHHhHHHHHHH----------HHHHHHH-HHHhhcCHHHHHHHHHHc Confidence 56788999999999999999999999999999998876443322 2233332 234566777888888887 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEV-GKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsev-gkqlrply 180 (805) .. ...+.+ ...+..++..|..+|...+ .++|.+.++|+++.++.+ ++|..||.+. +..++|.+ T Consensus 72 ~~-~~~~~~--~~~~~~~~~~~~~~~~~~~-----------~~~~~l~~~~~~~~~~~~--~~W~~~r~~~~~~~~~~~l 135 (509) T 3HOA_A 72 GS-PLVQDP--LSDAAVNVREWRQAYERAR-----------AIPERLAVELAQAESEAE--SFWEEARPRDDWRGFLPYL 135 (509) T ss_dssp TS-GGGSST--TSHHHHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHHHHHH--HHHHHHTTTTCHHHHHHHH T ss_pred CC-CCCCCC--CHHHHHHHHHHHHHHHHHc-----------CCCHHHHHHHHHcccHHH--HHHHHhhhhCChhhhHHHH Confidence 65 333332 4556678899999998766 678899999999999999 8999999998 89999999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYE----------DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMN 250 (805) Q Consensus 181 eeyvvlknemaranhye----------dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmn 250 (805) +++|-++|+.|+.+.|. ++.|||...|+- |...++++..|++|+|+|..||+|||.+. T Consensus 136 ~~~v~l~~~~A~~~g~~~~~~~~~~~~~~~d~~l~~ye~----------~~~~~~l~~l~~~l~~~~~~l~~~~~~~~-- 203 (509) T 3HOA_A 136 KRVYALTKEKAEVLFALPPAPGDPPYGELYDALLDGYEP----------GMRARELLPLFAELKEGLKGLLDRILGSG-- 203 (509) T ss_dssp HHHHHHHHHHHHHHHTSCCCTTSCCCCSHHHHHHHHHST----------TCCHHHHHHHHHHHHHHHHHHHHHHHTCS-- T ss_pred HHHHHHHHHHHHHhhcCCCCCCCCCCCCHHHHHHHccCC----------CCCHHHHHHHHHHHHHHHHHHHHHHHccC-- Confidence 99999999999999997 999999988872 22358899999999999999999999964 Q sp|Q9BYF1|ACE2 251 AYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWEN 330 (805) Q Consensus 251 aypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwen 330 (805) |. | |+|++ .+.+...+.++-++++|.+.|+.. ++ T Consensus 204 -~~----~----~~~~~-------------------------------~~~~~~~~~~~~~~~~~~~lG~~~------~~ 237 (509) T 3HOA_A 204 -KR----P----DTSIL-------------------------------HRPYPVEAQRRFALELLSACGYDL------EA 237 (509) T ss_dssp -CC----C----CGGGG-------------------------------GSCCCHHHHHHHHHHHHHHHTCCG------GG T ss_pred -CC----C----Cchhh-------------------------------cCCCCHHHHHHHHHHHHHHCCCCh------hh Confidence 21 1 44421 122233456788899999999886 12 Q sp|Q9BYF1|ACE2 331 SMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTK--VTMDDFLTAHHEMGHIQYDMAYAA----QPFLLRNGANEGFHEAV 404 (805) Q Consensus 331 smltdpgnvqkavchptawdlgkgdfrilmctk--vtmddfltahhemghiqydmayaa----qpfllrnganegfheav 404 (805) +. +. ..|||.+|+++.+|+||++|.. ..++++.+.|||+||..|.+.+.. +| ++.+++.+|||++ T Consensus 238 ~~------~d-k~~~~f~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~--~~~~~~~~~~E~~ 308 (509) T 3HOA_A 238 GR------LD-PTAHPFEIAIGPGDVRITTRYYEDFFNAGIFGTLHEMGHALYEQGLPKEHWGTP--RGDAVSLGVHESQ 308 (509) T ss_dssp EE------EE-ECSSCCEEEEETTEEEEEECCBTTBHHHHHHHHHHHHHHHHHHHHSCGGGTTSG--GGSCCCHHHHHHH T ss_pred CC------CC-CCCCcceeccCCCceEEEEeeccchhhHHHHHHHHHHHHHHHHhCCCHHHCCCC--CcCCCCchhHHHH Confidence 21 11 5799999999988999999998 899999999999999999998843 44 5678999999999 Q sp|Q9BYF1|ACE2 405 GEIMS----LSAATPKHLKS-----IGLLSPDFQEDNETEINF----LLKQALTIVGTLPFTYMLEKWRW--MVFKGEIP 469 (805) Q Consensus 405 geims----lsaatpkhlks-----igllspdfqedneteinf----llkqaltivgtlpftymlekwrw--mvfkgeip 469 (805) +..|. .+..+++++.. +|++++...++-...+|. ++++++..+. .|+.+++ +|+| .++.|+++ T Consensus 309 s~~~E~~~~~~~~~~~~l~~~~~~~~~~l~~~~~~~~~~~~~~~~~~l~r~~~~~~~-~~~~~~~-~~~~E~~l~~~~~~ 386 (509) T 3HOA_A 309 SRTWENLVGRSLGFWERFFPRAREVFASLGDVSLEDFHFAVNAVEPSLIRVEADEVT-YNLHILV-RLELELALFRGELS 386 (509) T ss_dssp HHCCCCCCTTSHHHHHHHHHHHHHHCGGGTTCCHHHHHHHTTCCCCCSCGGGCCTTT-HHHHHHH-HHHHHHHHHTTSCC T ss_pred HHHHHHHhcCCHHHHHHHHHHHHHHhhccCCCCHHHHHHHHHccChhHHHHHhHHhH-hhHHHHH-HHHHHHHHHcCCCC Confidence 99998 67778877765 676544324444566666 7888887765 8998888 9999 89999999 Q sp|Q9BYF1|ACE2 470 KDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSND--YSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDIS-- 545 (805) Q Consensus 470 kdqwmkkwwemkreivgvvepvphdetycdpaslfhvsnd--ysfiryytrtlyqfqfqealcqaakhegplhkcdis-- 545 (805) .+++-+.||+..++..|+..|. +...| ....|.+.. +.|.+|....++++|+.+++|+.. |+++.| +. T Consensus 387 ~~~l~~~w~~~~~~y~G~~~~~--~~~~~--~~~~h~~~~~~~Y~~~Y~~g~i~a~ql~~~~~~~~---~~~~~~-~~~~ 458 (509) T 3HOA_A 387 PEDLPEAWAEKYRDHLGVAPKD--YKDGV--MQDVHWAGGLFGYFPTYTLGNLYAAQFFQKAEAEL---GPLEPR-FARG 458 (509) T ss_dssp GGGHHHHHHHHHHHHHSCCCSS--STTTT--TSCSTTTTTCCSCTHHHHHHHHHHHHHHHHHHHHH---CCHHHH-HHHT T ss_pred HhHHhHHHHHHHHHHhCCCCCC--CCCCc--cccCcccCCccchhHHHHHHHHHHHHHHHHHHHHH---CChhHH-hhcC Confidence 9999999999999999987553 33333 444566543 345688899999999999999876 489999 54 Q sp|Q9BYF1|ACE2 546 NSTEAGQKLF-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTW 594 (805) Q Consensus 546 nsteagqklf-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplftw 594 (805) +..++|..|- ++++.|.+.+|.-.++.+.|. .++..+++.||++.+.- T Consensus 459 ~~~~~g~~l~~~il~~G~s~~~~ell~~~~G~-~l~~~~~l~~~~~~~~~ 507 (509) T 3HOA_A 459 EFQPFLDWTRARIHAEGSRFRPRVLVERVTGE-APSARPFLAYLEKKYAA 507 (509) T ss_dssp CCHHHHHHHHHHTGGGTTSSCHHHHHHHHHSS-CCCSHHHHHHHHHHHHH T ss_pred CcHHHHHHHHHhHHhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHH Confidence 4579999997 899999999999999999998 89999999999987753 No 20 >3DWC_B Metallocarboxypeptidase (E.C.3.4.17.19); metallocarboxypeptidase, cowrin family of metallocarboxypeptidases; HET: GOL, SO4; 2.1A {Trypanosoma cruzi} Probab=100.00 E-value=2e-44 Score=343.88 Aligned_cols=459 Identities=16% Similarity=0.165 Sum_probs=360.6 Template_Neff=9.700 Q sp|Q9BYF1|ACE2 23 EQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQE-I------QNLTVKL 95 (805) Q Consensus 23 eqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqe-i------qnltvkl 95 (805) ..|..||..++.+.+.+-++.++++|++.||+++.+.+.+..+..+++.++.+..+-.+++.+-+ + .+-..+. T Consensus 3 ~~~~~~l~~~~~~~~~l~~~~~~~~Wd~~t~~~~~~~~~~~~~~~~ls~~~~~~~~~~~~~~~~~~~~~~~~~ld~~~~r 82 (505) T 3DWC_B 3 MKPYKELERVFTKLYRYGHMLLLADWDSHTMMPCKGSDARGAAMAELQLHMHDTITAPKIRALIEEAEKSVGDLEKLQRA 82 (505) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCCGGGHHHHHHHHHHHHHHHHHHHTSHHHHHHHHHHHHTGGGSCHHHHH T ss_pred chHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCCCccHHHHHHHHHHHHHHHHhhhhCHHHHHHHHHHHhhcCCCCHHHHH Confidence 35778999999999999999999999999999999999999999999999999777555544211 1 1345677 Q sp|Q9BYF1|ACE2 96 QLQALQQN--GSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG 173 (805) Q Consensus 96 qlqalqqn--gssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg 173 (805) ||+.++.. ++..|+++.-++++.+.+.|+.+|++.+.||. . T Consensus 83 ~l~~l~~~~~~~~~lp~~~~~~~~~~~~~~~~~w~~~r~~~~-------------------------------------~ 125 (505) T 3DWC_B 83 NLREMRRAWELENLLPEEFVERKTVLTTKAHQVWKTCREKND-------------------------------------F 125 (505) T ss_dssp HHHHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHHHHHHHHTC-------------------------------------H T ss_pred HHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHhhhcCC-------------------------------------h Confidence 78888887 88899999999999999999999999888731 1 Q sp|Q9BYF1|ACE2 174 KQLRPLYEEYVVLKNEMARANHYE---DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMN 250 (805) Q Consensus 174 kqlrplyeeyvvlknemaranhye---dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmn 250 (805) +.++|.++++|-++++.|+.+.|+ +..|+|...|+ .|...++++..|++|+|+|..||++||.++.. T Consensus 126 ~~~~~~~~~~v~l~~~~A~~~g~~~~~~~y~~~~~~y~----------~~~~~~~ld~l~~~i~~~~~~l~~~v~~~~~~ 195 (505) T 3DWC_B 126 AGFLPTLKELIALFREEGKLRAGNSGKHPYEALVDIYE----------PGMTLQRLDEIFGNVRSWLPELLKEVQEKQKA 195 (505) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHTTSCCCHHHHHHHHHS----------TTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred hhhHHHHHHHHHHHHHHHHHHcCCCCCChHHHHHHHhC----------CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 578999999999999999999986 77778866555 34455889999999999999999999998762 Q sp|Q9BYF1|ACE2 251 AYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWEN 330 (805) Q Consensus 251 aypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwen 330 (805) |+ + +.+.+..||... ..++-++++|.++|... ++ T Consensus 196 -~~---------------~-------~~~~~~~p~~~~-----------------~~~~~~~~~~~~lg~~~------~~ 229 (505) T 3DWC_B 196 -LG---------------E-------TVLEPKGPFPVS-----------------KQEALCRFFMDVWKFDF------DG 229 (505) T ss_dssp -HC---------------C-------CCCCCCSCCCHH-----------------HHHHHHHHHHHHTTCCT------TS T ss_pred -hC---------------C-------CCCCCCCCCCHH-----------------HHHHHHHHHHHHcCCCc------cC Confidence 21 1 112334555221 23455677888888774 22 Q sp|Q9BYF1|ACE2 331 SMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTK--VTMDDFLTAHHEMGHIQYDMAY-AA----QPFLLRNGANEGFHEA 403 (805) Q Consensus 331 smltdpgnvqkavchptawdlgkgdfrilmctk--vtmddfltahhemghiqydmay-aa----qpfllrnganegfhea 403 (805) +.+ | ..|||.+|+++ +|+||.+|.+ .+++|+.+.|||+||++|.+.+ .. ||+. .+++-+|||+ T Consensus 230 ~~~-d------~~~~~f~~~~~-~d~ri~~~~~~~~~~~~~~~l~HE~GHa~y~~~~~~~~~~~~p~~--~~~~~~~~E~ 299 (505) T 3DWC_B 230 GRL-D------VSAHPFCGNSK-EDVRITTKYTETEFVTSLLGVIHETGHAKYEQNCGPKGFETQPVC--MARSLGVHEG 299 (505) T ss_dssp EEE-E------ECSSCCEEEET-TEEEEEECCBTTBSHHHHHHHHHHHHHHHHHHTCCCTTCTTSTTS--SCSCHHHHHH T ss_pred Cce-e------ecCCCccCCCC-CceEEEecCCchHHHHHHHHHHHHHHHHHHHhcCCCccccCCchh--hhcccchhHH Confidence 222 2 38999999985 8999999999 7799999999999999999988 43 7875 6899999999 Q sp|Q9BYF1|ACE2 404 VGE----IMSLSAATPKHLKSIGLLSPDFQEDN-------ETEIN----FLLKQALTIVGTLPFTYMLEKWRWMVFKGEI 468 (805) Q Consensus 404 vge----imslsaatpkhlksigllspdfqedn-------etein----fllkqaltivgtlpftymlekwrwmvfkgei 468 (805) ++. ++..++.+|+||..+... .|.... ..-++ .++++++..+..++...+...|+|-+|.|++ T Consensus 300 ~s~~~E~~~~~~~~~~~~l~~~~~~--~~~~~~~~~~~~l~~~l~~~~~~~~r~~~~~l~~~~~~~~~~~~e~~l~~g~~ 377 (505) T 3DWC_B 300 QSLFAEMQIGRSGAFMEFLAPRLVE--YFGDQPAFTSSNMKRVIQRVSPGLIRIDADELCYPLHVMLRYEIERDLMDGNI 377 (505) T ss_dssp HHHCCCCCCCTSHHHHHHHHHHHHH--HHCCCTTCSHHHHHHHHTCCCCCSCGGGCCTTTHHHHHHHHHHHHHHHHHTSS T ss_pred HHHHHHHHhhcCHHHHHHHHHHHHH--HHCCCCCCCHHHHHHHHhccCCcccHHHchhcchHHHHHHHHHHHHHHHcCCC Confidence 984 445677899999876322 222111 11122 3344444444444445566689999999999 Q sp|Q9BYF1|ACE2 469 PKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISN 546 (805) Q Consensus 469 pkdqwmkkwwemkreivgvvepvphdetycdpaslfhvsndy--sfiryytrtlyqfqfqealcqaakhegplhkcdisn 546 (805) +.+++.+.||+..++..|+..|.. + .-++.+.+|++.++ .+++|....++++|+.+++|+...+ +|++.| +.+ T Consensus 378 ~~~~l~~~w~~~~~~y~g~~~~~~-~--~~~~~~~~H~~~~~~~Y~~~Y~~~~i~a~ql~~~~~~~~~~-~~~~~~-~~~ 452 (505) T 3DWC_B 378 EAEEVPRVWNEKMKSYLGLETLGN-D--KEGCLQDVHWSGGMFGYFPTYSLGAMVAAQLMSCVRRELGE-EVVDDC-IRK 452 (505) T ss_dssp CGGGHHHHHHHHHHHHHSCCCTTC-C--TTTTTSCSTTTTTCCSCTHHHHHHHHHHHHHHHHHHHHHCH-HHHHHH-HHT T ss_pred CHHHhhHHHHHHHHHHcCCCCCCC-C--cCCccccccccccccccchHHHHHHHHHHHHHHHHHHHHCc-ccHHHH-Hhc Confidence 999999999999999999876542 2 22568889988765 5789999999999999999998764 689999 543 Q sp|Q9BYF1|ACE2 547 STEAGQKL----FNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFT 593 (805) Q Consensus 547 steagqkl----fnmlrlgksepwtlalenvvgaknmnvrpllnyfeplft 593 (805) .++|..+ -++++.|.+.+|.-.++.+.|. +++..+++.||+|+++ T Consensus 453 -~~~~~~~~~l~~~~l~~G~s~~~~e~l~~~~G~-~l~~~~~~~~~~~~~~ 501 (505) T 3DWC_B 453 -GDLGKILAKQNEKIWQHGSSLTTDELLRQATGE-TLNPEHYRRHLERRYR 501 (505) T ss_dssp -TCCHHHHHHHHHHTGGGTTSSCHHHHHHHHHSS-SCCTHHHHHHHCCCCC T ss_pred -CCHHHHHHHHHHhhhhcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHh Confidence 7788876 4899999999999999999998 9999999999999885 No 21 >5WVU_C Thermostable carboxypeptidase 1 (E.C.3.4.17.19); carboxypeptidase, RIKEN Structural Genomics/Proteomics Initiative; HET: GOL; 2.6A {Thermus thermophilus HB8} Probab=100.00 E-value=8.4e-44 Score=344.00 Aligned_cols=469 Identities=20% Similarity=0.238 Sum_probs=368.7 Template_Neff=9.300 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyplqeiqnltvklqlqalq 101 (805) ++++..||++++.+...+-...++++|++.|++++.+.+.... ..++|+... .+.+.+-.++-+|..++ T Consensus 3 ~~~~~~~L~~~~~~~~~~~~~~~~~~Wd~~t~~p~~~~~~r~~----------~~~~l~~~~-~~~~~~~~~~~~l~~~~ 71 (510) T 5WVU_C 3 PEAAYQNLLEFQRETAYLASLGALAAWDQRTMIPKKGHEHRAR----------QMAALARLL-HQRMTDPRIGEWLEKVE 71 (510) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCGGGHHHHHH----------HHHHHHHHH-HHHHTCHHHHHHHHHHT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhCCCHhhHHHHHH----------HHHHHHHHH-HHhhcCHHHHHHHHHHc Confidence 4678899999999999999999999999999999887643322 123343332 34556677888888887 Q sp|Q9BYF1|ACE2 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEV-GKQLRPLY 180 (805) Q Consensus 102 qngssvlsedkskrlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsev-gkqlrply 180 (805) .. ...+.+ ......++..|..+|...+ .++|.+.++|+++.++.+ ++|+.||... +..++|.+ T Consensus 72 ~~-~~~~~~--~~~~~~~~~~~~~~~~~~~-----------~~~~~l~~~~~~~~~~~~--~~W~~~r~~~~~~~~~~~l 135 (510) T 5WVU_C 72 GS-PLVQDP--LSDAAVNVREWRQAYERAR-----------AIPERLAVELAQAESEAE--SFWEEARPRDDWRGFLPYL 135 (510) T ss_dssp TS-GGGSST--TSHHHHHHHHHHHHHHHHH-----------HSCHHHHHHHHHHHHHHH--HHHHHHHHHTCHHHHHHHH T ss_pred CC-CCCCCC--CHHHHHHHHHHHHHHHHHc-----------CCCHHHHHHHHHcccHHH--HHHHHHhhhCChhhhHHHH Confidence 65 333332 4455667888988888655 678999999999999998 7999999988 89999999 Q sp|Q9BYF1|ACE2 181 EEYVVLKNEMARANHYE----------DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMN 250 (805) Q Consensus 181 eeyvvlknemaranhye----------dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmn 250 (805) +++|-++|++|+.+.|. ++.|||...|+ +|...++++..|++|+|++..||+|+|.+. T Consensus 136 ~~~v~l~~~~A~~~g~~~~~~~~~~~~~~~d~~l~~y~----------~~~~~~~l~~l~~~l~~~~~~l~~~~~~~~-- 203 (510) T 5WVU_C 136 KRVYALTKEKAEVLFALPPAPGDPPYGELYDALLDGYE----------PGMRARELLPLFAELKEGLKGLLDRILGSG-- 203 (510) T ss_dssp HHHHHHHHHHHHHHHTSCCSTTSCCCCSHHHHHHHHHS----------TTCCHHHHHHHHHHHHHHHHHHHHHHHTTC-- T ss_pred HHHHHHHHHHHHHhhcCCCCCCCCCCCCHHHHHHHhcC----------CCCCHHHHHHHHHHHHHHHHHHHHHHHccC-- Confidence 99999999999999997 99999988776 223358899999999999999999999964 Q sp|Q9BYF1|ACE2 251 AYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWEN 330 (805) Q Consensus 251 aypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgfwen 330 (805) |. | |+|++ .+.++..+.++-++++|.+.|+.. ++ T Consensus 204 -~~----~----~~~~~-------------------------------~~~~~~~~~~~~~~~~~~~lG~~~------~~ 237 (510) T 5WVU_C 204 -KR----P----DTSIL-------------------------------HRPYPVEAQRRFALELLSACGYDL------EA 237 (510) T ss_dssp -CC----C----CGGGG-------------------------------GSCCCHHHHHHHHHHHHHHHTCCG------GG T ss_pred -CC----C----Cchhh-------------------------------cCCCCHHHHHHHHHHHHHHCCCCc------hh Confidence 21 1 44421 122223446778889999999886 12 Q sp|Q9BYF1|ACE2 331 SMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTK--VTMDDFLTAHHEMGHIQYDMAYA----AQPFLLRNGANEGFHEAV 404 (805) Q Consensus 331 smltdpgnvqkavchptawdlgkgdfrilmctk--vtmddfltahhemghiqydmaya----aqpfllrnganegfheav 404 (805) +.+ | ..|||.+|+++.+|+||.+|.. .+++++.+.|||+||..|.+.+. -+| ++.+++.+|||+. T Consensus 238 ~~~-d------k~~~~f~~~~~~~d~rI~~~~~~~~~~~~~~~l~HE~GHa~~~~~~~~~~~~~~--~~~~~~~~~~E~~ 308 (510) T 5WVU_C 238 GRL-D------PTAHPFEIAIGPGDVRITTRYYEDFFNAGIFGTLHEMGHALYEQGLPKEHWGTP--RGDAVSLGVHESQ 308 (510) T ss_dssp CCE-E------ECSSCCEEEEETTEEEEEECCBTTBHHHHHHHHHHHHHHHHHHHTSCGGGTTSG--GGSCSCHHHHHHH T ss_pred CCC-C------CCCCCceeecCCCceEEEEeeecchhhHHHHHHHHHHHHHHHHcCCCHHHCCCC--CccCCCchhHHHH Confidence 211 1 5799999999989999999998 89999999999999999999874 355 4578999999999 Q sp|Q9BYF1|ACE2 405 GEIMS----LSAATPKHLKS-----IGLLSPDFQEDNETEINF----LLKQALTIVGTLPFTYMLEKWRW--MVFKGEIP 469 (805) Q Consensus 405 geims----lsaatpkhlks-----igllspdfqedneteinf----llkqaltivgtlpftymlekwrw--mvfkgeip 469 (805) +..|. .+..++++|.. +|++++.-.++-...+|. ++++++..+. +|+.+++ +|+| -++.|+++ T Consensus 309 S~~~E~~~~~~~~~~~~l~~~~~~~~~~l~~~~~~~~~~~~~~~~~~l~r~~~d~~~-~~~~~~~-~~~~e~~l~~~~~~ 386 (510) T 5WVU_C 309 SRTWENLVGRSLGFWERFFPRAREVFASLGDVSLEDFHFAVNAVEPSLIRVEADEVT-YNLHILV-RLELELALFRGELS 386 (510) T ss_dssp HHCCCCCCTTSHHHHHHHHHHHHHHCGGGTTCCHHHHHHHTTCCCCCSCSTTCCTTT-HHHHHHH-HHHHHHHHHHTSCC T ss_pred HHHHHHHhcCCHHHHHHHHHHHHHHhhccCCCCHHHHHHHHhccChhhhhHHhHHhH-hhHHHHH-HHHHHHHHhcCCCC Confidence 99998 66777777655 666544323333455666 7777777665 8998888 9999 89999999 Q sp|Q9BYF1|ACE2 470 KDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSND--YSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDIS-- 545 (805) Q Consensus 470 kdqwmkkwwemkreivgvvepvphdetycdpaslfhvsnd--ysfiryytrtlyqfqfqealcqaakhegplhkcdis-- 545 (805) .+++-+.||++.++..|+..|. +...| ....|.+.. +.|.+|....++++|+.+++|+.. |+++.| +. T Consensus 387 ~~~l~~~w~~~~~~y~G~~~~~--~~~~~--~~~~h~~~~~~~Y~~~Y~~g~i~a~qi~~~~~~~~---~~~~~~-~~~~ 458 (510) T 5WVU_C 387 PEDLPEAWAEKYRDHLGVAPKD--YKDGV--MQDVHWAGGLFGYFPTYTLGNLYAAQFFQKAEAEL---GPLEPR-FARG 458 (510) T ss_dssp GGGHHHHHHHHHHHHHSCCCSS--STTTG--GGCSGGGGTCCSCTHHHHHHHHHHHHHHHHHHHHH---CCSHHH-HHTT T ss_pred hhhHhHHHHHHHHHHhCCCCCC--CCCCc--cccccccCCcccchHHHHHHHHHHHHHHHHHHHHH---CChhHH-hhcC Confidence 9999999999999999987553 23333 344555543 345588899999999999999876 489999 65 Q sp|Q9BYF1|ACE2 546 NSTEAGQKLF-NMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWL 595 (805) Q Consensus 546 nsteagqklf-nmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwl 595 (805) +..++|+.|- ++++.|.+.+|.-.++.+.|. .++..+++.||++.+.-| T Consensus 459 ~~~~~g~~l~~~~l~~G~s~~~~ell~~~~G~-~l~~~~~l~~~~~~~~~~ 508 (510) T 5WVU_C 459 EFQPFLDWTRARIHAEGSRFRPRVLVERVTGE-APSARPFLAYLEKKYAAL 508 (510) T ss_dssp CCHHHHHHHHHHTGGGTTSSCHHHHHHHHHSS-CCCSHHHHHHHHHHHHHH T ss_pred CcHHHHHHHHHhHHHcccCCCHHHHHHHHHCC-CCCHHHHHHHHHHHHHHH Confidence 4478999987 899999999999999999998 899999999999987644 No 22 >3SKS_A Putative Oligoendopeptidase F; Structural Genomics, Center for Structural; HET: PO4; 2.05A {Bacillus anthracis} Probab=100.00 E-value=1.7e-38 Score=300.72 Aligned_cols=506 Identities=15% Similarity=0.182 Sum_probs=375.4 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQST-LA----QMYPLQEIQNLTVKLQ 96 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst-la----qmyplqeiqnltvklq 96 (805) ++++..+|..++.....+-...+.++|.|.+++|.+..+.+.......+..+..... +. +--+++++.. ..+-+ T Consensus 36 ~~~l~~~l~~~e~~~~~~~~~~~~a~~~~~~d~~d~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~~~~~l~~-~~~~~ 114 (567) T 3SKS_A 36 VEEQKQVIHSINEIRNDFGTMGNLCYIRHSVDTTDAFYKEEQDFFDEFSPVVQGYGTKYYNALIHSPFREELEA-YYGKQ 114 (567) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHhHHhHHHHHHHHHHHhcChhHHHHHH-HHHHH Confidence 456778899999888888899999999999999999877665544444433322211 11 1112222211 12335 Q sp|Q9BYF1|ACE2 97 LQALQQNGSSVLSEDKS---KRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVG 173 (805) Q Consensus 97 lqalqqngssvlsedks---krlntilntmstiystgkvcnpdnpqeclllepglneimansldynerlwaweswrsevg 173 (805) ++.+.+.+...++++.. ..++.+.+.+..++++.++|.++ +++.+ +.+..+|++ -|...|-.+|++|+...+ T Consensus 115 l~~~~~~~~~~l~e~~e~~l~~~~~~~~~~~~~~~~~~~~~~g---~~~~~-~~~~~~l~~-~d~~~R~~~~~a~~~~~~ 189 (567) T 3SKS_A 115 LFALAECDLKTYSDEVVKDLQLENKLSSQYTQLLASAKIDFAG---EERTL-SQLIPFMQG-KERSERKAASEAYYGFLA 189 (567) T ss_pred HHHHHHHHhhcCCHHHHHHHHHHHHHHHHHHHHHhcCEEEeCC---EEEeH-HHHHHHHhC-CCHHHHHHHHHHHHHHHh Confidence 55566666666666422 23456668888999999999773 56666 889999996 899999999999998766 Q sp|Q9BYF1|ACE2 174 K---QLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMN 250 (805) Q Consensus 174 k---qlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmn 250 (805) + .+++++.++|-+.+++|+.+.|.+|.+||.-.. .+.+|+...+..-++...++++|+|+.+|+++|.++-. T Consensus 190 ~~~~~~~~~l~~lv~~r~~~A~~~Gy~~~~~~~l~~~-----~~~~~~~~~~~~~l~~l~~~~~p~~~~~~~~~~~~lg~ 264 (567) T 3SKS_A 190 ENEEELDRIYDELVKVRTKIAKSLGFKNFVELGYARM-----YRTDYNAEMVANYRQQVLDYIVPVTTELRKRQQARIGV 264 (567) T ss_pred cCccchHHHHHHHHHHHHHHHHHcCCCCHHHHHHHHh-----hhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhCC Confidence 5 579999999999999999999999999997432 23455555555566666777999999999998876510 Q sp|Q9BYF1|ACE2 251 AYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFG-QKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLP------NM 323 (805) Q Consensus 251 aypsyispigclpahllgdmwgrfwtnlysltvpfg-qkpnidvtdamvdqawdaqrifkeaekffvsvglp------nm 323 (805) .++ +.|...+.++ .+ ..| .+....+++.++.+|-+.|.. .| T Consensus 265 -------------~~l------~~~d~~~~~~--~~~~~~-----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 312 (567) T 3SKS_A 265 -------------EKL------AYYDENFEFP--TGNPTP-----------KGDADWIVNHGKTMYKELSAETDEFFNFM 312 (567) T ss_pred -------------CCC------CcccccCCCC--CCCCCC-----------CCCHHHHHHHHHHHHHhhCHHHHHHHHHH Confidence 011 3443333221 11 112 223457788888888888875 46 Q sp|Q9BYF1|ACE2 324 TQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAA-QPFLLRNGANEGFHE 402 (805) Q Consensus 324 tqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaa-qpfllrnganegfhe 402 (805) ...+|-+ ....||....+.|++.. +.++++|+||...+.+|+.+.+|||||..+.+.... +|+..+. .+.+|+| T Consensus 313 ~~~~~iD-~~~r~~K~~g~~~~~~~---~~~~~~i~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~-~~~~~~E 387 (567) T 3SKS_A 313 LDNDLLD-LVAKKGKAGGGYCTYIE---NYKAPFIFSNFNGTSGDIDVLTHEAGHAFQVYESRKFEIPEYNW-PTYEACE 387 (567) T ss_pred ccccccc-cCCCCCCCCCceeecCC---CCCCCEEEEeCCCCHHHHHHHHHHHHHHHHHHHccCCCCCCCCC-CCHHHHH Confidence 6667765 44556777778999854 457899999999999999999999999998887654 4554555 4568999 Q sp|Q9BYF1|ACE2 403 AVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFK-GEIPKDQWMKKWWEMK 481 (805) Q Consensus 403 avgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfk-geipkdqwmkkwwemk 481 (805) +++..|.+....+ |... +..+. + ..++.+++..+.++|+.+++.+|+|.++. |+++.+++-+.||+.. T Consensus 388 ~~S~~~E~l~~~~--l~~~------~~~~~--~-~~l~~~~~~~~~~l~~~~~~~~~e~~~~~~~~~~~~~~~~~~~~~~ 456 (567) T 3SKS_A 388 IHSMSMEFFTWPW--MKLF------FEEDA--D-KYYFSHLSSALLFLPYGVSVDEYQHYVYENPEASPEERKTAWRNIE 456 (567) T ss_pred HHHHHHHHHhHHH--HHHh------CCCHH--H-HHHHHHHHHHHhHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH Confidence 9999888877644 4321 11111 2 37888899999999999999999999997 8898899999999999 Q sp|Q9BYF1|ACE2 482 REIVGVVEPVPHD--ETYCDPASLFHVS-NDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNML 558 (805) Q Consensus 482 reivgvvepvphd--etycdpaslfhvs-ndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml 558 (805) ++.-|++.|.+.+ +..+++++..|+. .....+.|....+.++|+.+.+|.. +.++|.++.++| T Consensus 457 ~~y~g~~~~~~~~~~~~~~~w~~~~h~~~~~~y~~~Y~~~~~~a~~l~~~~~~~--------------~~~~~~~~~~~l 522 (567) T 3SKS_A 457 KKYLPHRDYEDNDYLERGGFWQRQGHIYSSPFYYIDYTLAQICALQFWKRARDN--------------RQEAWEDYVNLC 522 (567) T ss_pred HHHCCCCCCCCCCCccccCChhhCCccccCCchHHHHHHHHHHHHHHHHHHHHc--------------cHHHHHHHHHHH Confidence 9999987776654 5677888888887 4677889999999999999999874 246789999999 Q sp|Q9BYF1|ACE2 559 RLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNK 600 (805) Q Consensus 559 rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnk 600 (805) +.|.+.||.-.++.+.|.....-..+.+++++|-.|++.+|. T Consensus 523 ~~G~s~~~~e~l~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~ 564 (567) T 3SKS_A 523 QQGGSKSFLELVEVANLTSPFAEGCVKSVITEIEAWLHAIDD 564 (567) T ss_pred HccCCCCHHHHHHHcCCCCCCChhHHHHHHHHHHHHHHHhhh Confidence 999999999999988776555566788899999999987663 No 23 >3AHN_A Oligopeptidase; HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex; HET: ACT, 3A1; 1.8A {Geobacillus sp. MO-1} Probab=100.00 E-value=2.6e-38 Score=299.31 Aligned_cols=505 Identities=14% Similarity=0.150 Sum_probs=360.1 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 22 EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNN----AGDKWSAFLKEQ-STLAQMYPLQEIQNLTVKLQ 96 (805) Q Consensus 22 eeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnn----agdkwsaflkeq-stlaqmyplqeiqnltvklq 96 (805) ++++..+++.++.....+-...++++|.|.+|+|.+..+.+.. ...++...+.+. ..+.+-..++ .+. +-. T Consensus 33 ~~~~~~~l~~~e~~~~~~~~~~~~a~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~---~~~-~~~ 108 (564) T 3AHN_A 33 AEEQNEAMKEINQLRNDFSTMAQICYIRHTIDTNDEFYKQEQDFFDEVEPIVKGLVNDYYRALVSSPFRS---QLE-GKW 108 (564) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCTTHH---HHH-HHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCchHH---HHh-hhh Confidence 4677788888888888888999999999999999988775432 222333332211 0111100011 110 011 Q sp|Q9BYF1|ACE2 97 LQALQQNGSSV--LSEDKSKRLNTILNTMSTIYS----TGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRS 170 (805) Q Consensus 97 lqalqqngssv--lsedkskrlntilntmstiys----tgkvcnpdnpqeclllepglneimansldynerlwaweswrs 170 (805) +..+.+..... ..+++-..+......++..|+ +.++|-.+ +++.+ +.+..+|. +-|...|-.+|++|+. T Consensus 109 ~~~~~~~~~~~l~~~~~~~~~~~~~~~~l~~~y~~~~~~~~~~~~g---~~~~~-~~~~~~~~-~~d~~~R~~~~~~~~~ 183 (564) T 3AHN_A 109 GKQLFALAEAELKTYSPDIVEDLQLENKLTSEYTKLVASAKIFFEG---EERTL-AQLQPFVE-SPDRDMRKRASEARFT 183 (564) T ss_dssp CTHHHHHHHHHHTTCCGGGHHHHHHHHHHHHHHHHHHHTCCEEETT---EEECT-GGGHHHHT-CSSHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHhhhcChhhHHHHHHHHHHHHHHHHHHhccEEEeCC---EEEeH-HHHHHHhc-CCCHHHHHHHHHHHHH Confidence 11111111111 223333444444556666666 88888542 35555 88999986 8899999999999999 Q sp|Q9BYF1|ACE2 171 EVGK---QLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAK 247 (805) Q Consensus 171 evgk---qlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvrak 247 (805) ..++ .++++|.+.|-+++++|+.+.|.+|.+||...+. ..+++...+..-++...++++|+|+.+++++|.. T Consensus 184 ~~~~~~~~~~~~~~~lv~~r~~~A~~~Gy~~~~~~~l~~~~-----~~~~~~e~~~~~~~~l~~~~~p~~~~~~~~~~~~ 258 (564) T 3AHN_A 184 FFQEHEEKFDEIYDQLVKVRTAIAQKLGFKNFVELGYARLG-----RTDYNAEMVAKFRKQVEKHIVPIAVKLRERQRER 258 (564) T ss_dssp HHHHTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHHHTT-----CCSCCHHHHHHHHHHHHHHTHHHHHHHHHHHHHH T ss_pred HHHHCHHHHHHHHHHHHHHHHHHHHHcCCCCHHHHHHHHcc-----cCCCCHHHHHHHHHHHHHhchHHHHHHHHHHHHH Confidence 8876 6999999999999999999999999999964321 1345555555556666778899999999988864 Q sp|Q9BYF1|ACE2 248 LMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGF 327 (805) Q Consensus 248 lmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsvglpnmtqgf 327 (805) + |...-+.|... .||.....++. .++..+|+.++++|.+ ++.+...| T Consensus 259 l-------------------g~~~~~~~d~~----~~~~~~~~~~~--------~~~~~~~~~~~~~~~~--~~~~~~~~ 305 (564) T 3AHN_A 259 I-------------------GVEKLKYYDEA----FVFPTGNPMPK--------GDANWIIENGKKMYEE--LSPETGEF 305 (564) T ss_dssp H-------------------TCSSCCTTTTT----CCCTTCCCCCS--------SCHHHHHHHHHHHHHH--HCHHHHHH T ss_pred H-------------------Ccccccccccc----ccCCCCCCCCC--------CCHHHHHHHHHHHHHH--hCHHHHHH Confidence 3 32222334322 23332211111 1455677788888866 44455677 Q sp|Q9BYF1|ACE2 328 WENSM-------LTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGF 400 (805) Q Consensus 328 wensm-------ltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmayaaqpfllrnganegf 400 (805) |++.. ...||....+.|++.. ..+++||+||...+++|+.+.+||+||.++.+.+..++.+..++.+.+| T Consensus 306 ~~~~~~~~~~D~~~r~~K~~g~~~~~~~---~~~~~~i~~n~~~~~~~~~tl~HE~GHa~h~~~~~~~~~~~~~~~~~~~ 382 (564) T 3AHN_A 306 FRYMIEHELMDLVAKKGKASGGYCTYIE---NYKAPFIFSNFTGTSGDIDVLTHEAGHAFQVYESRHYEIPEYNWPTLEA 382 (564) T ss_dssp HHHHHHTTCEEEECCTTCCSSCEEEEEG---GGTEEEEEEEECSSTHHHHHHHHHHHHHHHHHHTTTCSSGGGSSCCHHH T ss_pred HHHHHHcCCcccccCCCCCCCceeeeec---CCCCcEEEEcCCCChhHHHHHHHHHHHHHHHHHccCCCCccccCCcHHH Confidence 77652 2345555568999865 3577899999999999999999999999998877666655556788999 Q sp|Q9BYF1|ACE2 401 HEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFK-GEIPKDQWMKKWWE 479 (805) Q Consensus 401 heavgeimslsaatpkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfk-geipkdqwmkkwwe 479 (805) +|+.+..|.+....+ |+.. ++ +... ..++.+++.++..+|+.+++..|+|-++. |.++.+++-+.||+ T Consensus 383 ~E~~s~~~e~l~~~~--l~~~--~~-----~~~~--~~~~~~l~~~~~~l~~~~~~~~fe~~ly~~~~~~~~~~~~~~~~ 451 (564) T 3AHN_A 383 CEIHSMSMEFFTWPW--MKLF--FK-----EDAE--KYQFYHLSDALLFLPYGVAVDEFQHFVYENPNATPAERKQAWRA 451 (564) T ss_dssp HHHHHHHHHHHTGGG--HHHH--HG-----GGHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTCCHHHHHHHHHH T ss_pred HHHHHHHHHHhhHHH--HHHH--cc-----chHH--HHhHHHHHHHHHHHHHHHHHHHHHHHHHhCCCCCHHHHHHHHHH Confidence 999999988877644 4431 11 1111 13445566778889999999999999999 88888999999999 Q sp|Q9BYF1|ACE2 480 MKREIVGVVEPVPHD--ETYCDPASLFHVSN-DYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFN 556 (805) Q Consensus 480 mkreivgvvepvphd--etycdpaslfhvsn-dysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfn 556 (805) +..+..|++.|.+.+ +..+++.+..|+.. ....+.|....+.++|+.+.+|+. +.++|.++.+ T Consensus 452 ~~~~y~g~~~~~~~~~~~~~~~w~~~~H~~~~~~yy~~Y~~s~~~a~~l~~~~~~~--------------~~~~~~~~~~ 517 (564) T 3AHN_A 452 IERKYMPTKDYDGNDYLERGGFWQRQSHIYTTAFYYIDYTLAQICAFQFWKRSREN--------------YKEAWNDYLT 517 (564) T ss_dssp HHHHHSTTCCCTTCHHHHTTCGGGGCHHHHHSTTTTHHHHHHHHHHHHHHHHHHHC--------------HHHHHHHHHH T ss_pred HHHHHCCCCCCCCCchhhcCCChhhccchhcCchHHHHHHHHHHHHHHHHHHHHHh--------------HHHHHHHHHH Confidence 999998876665544 56778888889875 556788999999999999988865 2568999999 Q sp|Q9BYF1|ACE2 557 MLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKN 601 (805) Q Consensus 557 mlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnkn 601 (805) +|+.|.+.||.-.++.+-|...+...+++.||+||..||+.+|+- T Consensus 518 ~l~~G~s~~~~e~l~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~ 562 (564) T 3AHN_A 518 LCRQGGSKPFTELVRVANLISPFEDGCVQSVVGGIEGWLNSVDDQ 562 (564) T ss_dssp HHTTTTSSCHHHHHHHTTCCCTTSTTHHHHHHHHHHHHHTTSCGG T ss_pred HHhcCCCCCHHHHHHHCCCCCCCChhHHHHHHHHHHHHHhccccc Confidence 999999999999999977767899999999999999999998864 No 24 >2QR4_A Peptidase M3B, oligoendopeptidase F; structural genomics, oligoendopeptidase F, PSI-2; 2.5A {Enterococcus faecium} Probab=99.95 E-value=2e-33 Score=267.60 Aligned_cols=506 Identities=14% Similarity=0.121 Sum_probs=318.6 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 23 EQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNN-AGDKWSAFLKEQSTLAQM---YPLQ---E-----IQN 90 (805) Q Consensus 23 eqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnn-agdkwsaflkeqstlaqm---yplq---e-----iqn 90 (805) +..+.+|+.++.....+-...+.+.|.+.++++.+..+.+.. ...+.+.+.+..+.+.+. .|.. + .+. T Consensus 34 ~~l~~~l~~~e~~~~~l~~~~~ya~~~~~~d~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~l~~~~~~~~l~~~~~l 113 (587) T 2QR4_A 34 SQFLNAIEFVLRVYRQTEVIYVYAHLKNDQDTGNTDYQALYARASSLFSKVSEAVSWFEPEILQLSDDQIWQYFKEEPKL 113 (587) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTCHHHHHHHHHHHHHHHHHHHHTTTHHHHHTTSCHHHHHHHHHHCGGG T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHhcchhHHHHcCCHHHHHHHHHhChhh Confidence 455666777777777788889999999999999986665443 333333333322222111 1111 1 112 Q sp|Q9BYF1|ACE2 91 LTVKLQLQALQQNGSSVLSEDKSKRLNTI---LNTMSTIYSTG---KVCNPD----NPQECLLLEPGLNEIMANSLDYNE 160 (805) Q Consensus 91 ltvklqlqalqqngssvlsedkskrlnti---lntmstiystg---kvcnpd----npqeclllepglneimansldyne 160 (805) -..+-.|+.+.+.+...|+++..+.+.++ ++.++.+|++- .+|-++ +..++-+-.+.+..+|+ +-|... T Consensus 114 ~~~~~~l~~~~~~~~~~Ls~~~e~~l~~~~~~~~~~~~~y~~~~~~~~~~~~~~~~~g~~~~l~~~~~~~~l~-~~d~~~ 192 (587) T 2QR4_A 114 EVYRHYIQQIVDNRAHVLSAEQESLLAGAGEIFDASSDTFAVLNNADLVFPTIEGENGEIVQLSHGVYGQLLE-STDRRV 192 (587) T ss_dssp GGGHHHHHHHHTTGGGCCCHHHHHHHHHTHHHHHHHHHHHHHCCCCCCCCCEEECTTSCEEECCHHHHHHHHT-CSCHHH T ss_pred HhhHHHHHHHHHcCCcCCCHHHHHHHHHHhhhhHHHHHHHHHHHhhccccCcccCCCCcEEEcCHHHHHHHhh-CCCHHH Confidence 25566777788888899999988877666 77888899884 666552 23333333456888999 899999 Q sp|Q9BYF1|ACE2 161 RLWAWESWRSEVG---KQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLY 237 (805) Q Consensus 161 rlwaweswrsevg---kqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikply 237 (805) |..+|++|++..+ ..+.++|.+++.+.+++|+.+.|.+|.+||..++++. -+.++..++.|++++ T Consensus 193 R~~~~~a~~~~~~~~~~~~~~~l~~lv~~~~~~A~~~Gy~~~~~~~l~~~~~~------------~~~~~~l~~~i~~~~ 260 (587) T 2QR4_A 193 REAAFKGLYSVYEQFRNTFASTLGTHIKGHNFKAKVRNYSSAREASLSNNHIP------------ESVYDTLVDVVNKHL 260 (587) T ss_dssp HHHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHHTTTCC------------HHHHHHHHHHHHHTH T ss_pred HHHHHHHHHHHHHHhHHHHHHHHHHHHHhhHHHHHHcCCCCHHHHHHhhcCCC------------HHHHHHHHHHHHHhh Confidence 9999999998876 4899999999999999999999999999997765531 144557788999999 Q sp|Q9BYF1|ACE2 238 EHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQ--KPNIDVTDAMVDQAWDA-----QRIFKE 310 (805) Q Consensus 238 ehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgq--kpnidvtdamvdqawda-----qrifke 310 (805) ..+|+|+|.++.. + |. + . -+.|.. | .|+.. .+.+++ +..++....+ ..+++- T Consensus 261 ~~~~~~~~~~~~~-~-------g~-~-~------l~~~D~-~---~~~~~~~~~~~~~-~e~~~~~~~~~~~~~~~~~~~ 319 (587) T 2QR4_A 261 PLLHRYMELRKRL-L-------EV-E-K------LHMYDL-Y---TPVLGEAPITFTY-EEAKEKALEALKPMGEEYMAI 319 (587) T ss_dssp HHHHHHHHHHHHH-H-------TC-S-S------BCGGGS-S---SCSSCCCCC------CCHHHHHHHTGGGHHHHHHC T ss_pred HHHHHHHHHHHHH-h-------CC-C-C------cchhhc-C---CCCCCCCCCccCH-HHHHHHHHHHhHhhCHHHHHH Confidence 9999999876542 1 11 0 0 022322 1 22222 244554 2233332222 234444 Q sp|Q9BYF1|ACE2 311 AEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYA-AQP 389 (805) Q Consensus 311 aekffvsvglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmaya-aqp 389 (805) ++++| +.| |-. +...||....+.|++.. .++++|+||...+.+|+.|.+||+||..+.+... .+| T Consensus 320 ~~~~~-~~~--------~id-~~~r~~K~~g~~~~~~~----~~~~~I~~~~~~~~~~~~tl~HE~GHa~h~~~~~~~~~ 385 (587) T 2QR4_A 320 VEKAF-SER--------WID-VVENKGKRSGAYSSGSY----DTNPYILLNWHDTLDQLFTLVHEMGHSVHSYFTRSNQP 385 (587) T ss_dssp ------------------------------------------------------CHHHHHHHHHHHHHHHHHHHC----- T ss_pred HHHHH-HcC--------CeE-eecCCCCCCCceecCCC----CCCcEEEeecCCChHHHHHHHHHHHHHHHHHHhhcCCC Confidence 55544 333 211 11134555567787643 3589999999999999999999999999988776 678 Q sp|Q9BYF1|ACE2 390 FLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTI-VGTLPFTYMLEKWRWMVFKG-- 466 (805) Q Consensus 390 fllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinfllkqalti-vgtlpftymlekwrwmvfkg-- 466 (805) .+.+. .+.+|+|+++..|..-... + |+. .+ +...+++.+++++++- +++++...+...|.+-++.+ T Consensus 386 ~~~~~-~~~~~~E~~S~~~E~l~~~--~-----L~~-~~--~~~~~~~~l~~~~l~~~~~~l~~~~~~~~fe~~~~~~~~ 454 (587) T 2QR4_A 386 YVYGD-YSIFLAEIASTTNENILTE--Y-----LLE-TE--KDPRVRAYVLNHYLDGFKGTVFRQTQFAEFEHFMHTEDE 454 (587) T ss_dssp --------CHHHHHHHHHHHHHHHH--H-----HHH-HC--CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH T ss_pred hhhcc-CcHHHHHHHHHHHHHHHHH--H-----HHH-hC--CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 87775 6778888888777654322 2 321 11 1223478888888763 67888888888888888876 Q sp|Q9BYF1|ACE2 467 ---EIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCD 543 (805) Q Consensus 467 ---eipkdqwmkkwwemkreivgvvepvphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcd 543 (805) .++.+.+.+-||+..++..|+..|.. ++..++....+|....|-...|..-.+.++|+.+.+|+. T Consensus 455 ~~~~l~~~~l~~~~~~~~~~~~g~~~~~~-~~~~~~w~~~~h~~~~~Y~~~y~~~~~~~~~l~~~~~~~----------- 522 (587) T 2QR4_A 455 KGVPLTSEYLSDSYGKLNAKYYGPAVEED-PEIKFEWSRIPHFYYNYYVFQYSTGFSAASALAKKILNQ----------- 522 (587) T ss_dssp TTCCCCHHHHHHHHHHHHHHHHCTTBCCC-GGGGGGGGGCGGGGSSSCTHHHHHHHHHHHHHHHHHHTT----------- T ss_pred cCCCCCHHHHHHHHHHHHHHHhCCCCCCC-hhhccHhHcCcchhcccccHHHHHHHHHHHHHHHHHHhc----------- Confidence 56678899999999999999876653 334556666677664444455555566677777777762 Q sp|Q9BYF1|ACE2 544 ISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSF 603 (805) Q Consensus 544 isnsteagqklfnmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsf 603 (805) +.++|.++..+|+.|.+.||.-.++. +|.......++..+|.|+-.||+..++..- T Consensus 523 ---~~~~~~~~~~~l~~G~s~~~~ell~~-~G~~~~~~~~~~~~~~~l~~~l~~~~~~~~ 578 (587) T 2QR4_A 523 ---EPEALENYLAYLKAGNSDYPVEVMKK-AGVDMTQAAYIEDAMSMFEQRLNELEELID 578 (587) T ss_dssp ---CTTHHHHHHHHHHHCSCSCHHHHHHH-TTCCTTSSHHHHHHHHHHHHHHHHHHHHHH T ss_pred ---ChHHHHHHHHHHHcCCCCCHHHHHHH-cCCCCCCcHHHHHHHHHHHHHHHHHHHHHH Confidence 36789999999999999999999997 999988888999999999999998876543 No 25 >2O36_A Thimet oligopeptidase (E.C.3.4.24.15); thermolysin-like domain, substrate-binding channel, HYDROLASE; 1.95A {Homo sapiens} Probab=99.92 E-value=5e-30 Score=254.55 Aligned_cols=518 Identities=16% Similarity=0.181 Sum_probs=335.6 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 26 KTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP-------------LQEIQNLT 92 (805) Q Consensus 26 ktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp-------------lqeiqnlt 92 (805) ..++..++.....+....++++|.++++++++..+....+-.++++|..+..+-...|. +.+.+... T Consensus 47 ~~~v~~~d~~~~~l~~~~~~~~~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~ld~e~~r~ 126 (674) T 2O36_A 47 ESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARY 126 (674) T ss_dssp CCCCCHHHHHHHHHHHHHHHHHSHHHHCSCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHHHHSCTTCSCHHHHHH T ss_pred HHHHHHHHHhhHHHHHHHHHHhHHHHhCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHHHhhchhcCCHHHHHH Confidence 34566666667777888999999999999999999999999999999999877666665 23333445 Q sp|Q9BYF1|ACE2 93 VKLQLQALQQNGSSVLSEDKSKRLNTI---LNTMSTIYSTGKVCNPD-------------------------NPQECLLL 144 (805) Q Consensus 93 vklqlqalqqngssvlsedkskrlnti---lntmstiystgkvcnpd-------------------------npqeclll 144 (805) ++..++.++++|.. |++++.+++..+ ++.+++.|+....|.+. .+ -++.+ T Consensus 127 l~~~l~~~~~~G~~-L~~~~~~~~~~l~~~i~~l~~~f~~~~~~~~~~~~~~~~~l~g~p~~~~~~~~~~~~~~-~~~~l 204 (674) T 2O36_A 127 LERLIKLGRRNGLH-LPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGK-LKVTL 204 (674) T ss_dssp HHHHHHHHHHTTTT-SCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECTTTTTTSCHHHHTTSEECTTSC-EEEES T ss_pred HHHHHHHHHHcCCC-CCHHHHHHHHHHHHHHHHHHHHHHHccCCCccccceeHHHhcCCCHHHHHHHHhhhCCC-EEEec Confidence 66677788888865 666565666555 55578888888777643 12 13333 Q sp|Q9BYF1|ACE2 145 -EPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLI 223 (805) Q Consensus 145 -epglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqli 223 (805) .|.+..+|+++-|...|..+|+.|+...++...+++++.+.+++++|+...|.+|.+||..+..+ .+..++. T Consensus 205 ~~~~~~~il~~~~d~~~R~~~~~a~~~~~~~~~~~~l~~ll~lR~~~A~llGy~s~~~~~l~~~~~-------~~~~~v~ 277 (674) T 2O36_A 205 KYPHYFPLLKKCHVPETRRKVEEAFNSRCKEENSAILKELVTLRAQKSRLLGFHTHADYVLEMNMA-------KTSQTVA 277 (674) T ss_dssp SHHHHHHHHHHCCCHHHHHHHHHHHTTTTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSTT-------CSHHHHH T ss_pred CChhhHHHHhhCCCHHHHHHHHHHHHcCCchHHHHHHHHHHHHHHHHHHHhCCCCHHHHHhhccCC-------CCHHHHH Confidence 57789999999999999999999998877788999999999999999999999999999764332 2233444 Q sp|Q9BYF1|ACE2 224 EDVEHTFEEIKPLYEHLHAYVRAK---LMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQ 300 (805) Q Consensus 224 edvehtfeeikplyehlhayvrak---lmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdq 300 (805) +-++...+.++|+|+..++.+++. ....+.. +..+.+ ..|...|-...... ...++.++.+.+ T Consensus 278 ~~l~~l~~~~~p~~~~~~~~l~~~~~~~~~~~g~--~~~~~l----------~~wD~~y~~~~~~~--~~~~~~~~~~~~ 343 (674) T 2O36_A 278 TFLDELAQKLKPLGEQERAVILELKRAECERRGL--PFDGRI----------RAWDMRYYMNQVEE--TRYCVDQNLLKE 343 (674) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTC--CCCSSC----------CTTTHHHHHHHHCC--CCCCCCHHHHGG T ss_pred HHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHCCC--CCCCCC----------ChhcHHHHHHHHHH--hccCCCHHHHHh Confidence 445555678899998876655442 2222210 001111 23444444443322 234444555555 Q sp|Q9BYF1|ACE2 301 AWD----AQRIFKEAEKFFVSVGLPNM---TQGFWENSML-----------------T----DPGNVQKAVCHPTAWDLG 352 (805) Q Consensus 301 awd----aqrifkeaekffvsvglpnm---tqgfwensml-----------------t----dpgnvqkavchptawdlg 352 (805) .+. ...+++.++++| |+.-. ..-+|..+.. . .||....+.|++...+.. T Consensus 344 yf~~~~v~~~l~~~~~~~f---g~~~~~~~~~~~W~~~v~~~~v~d~~~~~~lg~~ylD~~~r~~K~~~a~~~~~~~~~~ 420 (674) T 2O36_A 344 YFPVQVVTHGLLGIYQELL---GLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCL 420 (674) T ss_dssp GCBHHHHHHHHHHHHHHHH---TEEEEECTTCCCSSTTCEEEEEEETTTCCEEEEEEEECSCCTTSCCSCEEEEEECCEE T ss_pred hCCHHHHHHHHHHHHHHHh---CcEEEeCCCCCcccCCceEEEEEeCCCCcEEEEEEEeCCCCCCCCCCCceeeEeCCcc Confidence 443 245666666666 43221 2345665553 1 234433455554332211 Q sp|Q9BYF1|ACE2 353 K--GDF-----RI---------LMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEG--FHEAVGEIMSLSAAT 414 (805) Q Consensus 353 k--gdf-----ri---------lmctkvtmddfltahhemghiqydmayaaqpfllrnganeg--fheavgeimslsaat 414 (805) . |+. .| -.|+.++++|+.|.+||+||..+.+.+..++..+ .|.+-+ |+|+++.+|.+.+.. T Consensus 421 ~~~~~~~~P~~~i~~n~~~~~~~~~~ll~~~~v~tl~HE~GHalh~~l~~~~~~~~-~g~~~~~d~~E~~S~~~E~~~~~ 499 (674) T 2O36_A 421 RQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVRTYFHEFGHVMHQLCSQAEFAMF-SGTHVETDFVEAPSQMLENWVWE 499 (674) T ss_dssp CTTSCEECEEEEEECCCCCCBTTBCCBCCHHHHHHHHHHHHHHHHHHHCCCSSGGG-STTCSCTTTTTHHHHHHHGGGGS T ss_pred cCCCCeeceEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHhcCCcccc-cCCcccchhhcchhHHHHHhhcC Confidence 0 111 22 1578888999999999999999999988766554 566655 999999999999999 Q sp|Q9BYF1|ACE2 415 PKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIP---KDQWMKKWWEMKREIVGVVEPV 491 (805) Q Consensus 415 pkhlksigllspdfqedneteinfllkqaltivgtlpftymlekwrwmvfkgeip---kdqwmkkwwemkreivgvvepv 491 (805) |++|+.++.-..+-+.-.+..++.++.. ....+..++++.+.+-.|..++- .+++.+.||++.++..|+ |+ T Consensus 500 ~~~L~~l~~~~~~~~~l~~~~~~~l~~~----~~~~~~~~~~~~~~~~~~d~~l~~~~~~~~~~~~~~l~~~~~g~--~~ 573 (674) T 2O36_A 500 QEPLLRMSRHYRTGSAVPRELLEKLIES----RQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGV--PA 573 (674) T ss_dssp HHHHHHTCCCTTTCCCCCHHHHHHHHHG----GGTTHHHHHHHHHHHHHHHHHHTTCSSCCHHHHHHHHCCCCCSS--CC T ss_pred hHHHHHHcccCCCCCCCCHHHHHHHHHH----hhHhHHHHHHHHHHHHHHHHHHhCCCCCCHHHHHHHHHHHHhCC--CC Confidence 9999988743221111112233333321 11222222333444434433332 356889999999999887 33 Q sp|Q9BYF1|ACE2 492 PHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQ-AAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWTLA 569 (805) Q Consensus 492 phdetycdpaslfhvsndysfiryytrtlyqfqfqealcq-aakhegplhkcdisnsteagqklf-nmlrlgksepwtla 569 (805) +. ...++.+..|+..+|.+ .|| .-++..-+...+.+ ..+..||+ +.++|.++. ++|..|.+.+|.-. T Consensus 574 ~~--~~~~~~~~~Hl~~~y~~-~yy-~Yl~s~vlA~~i~~~~f~~~~~~-------~~~~g~~~~~~~L~~G~s~~~~e~ 642 (674) T 2O36_A 574 TP--GTNMPATFGHLAGGYDA-QYY-GYLWSEVYSMDMFHTRFKQEGVL-------NSKVGMDYRSCILRPGGSEDASAM 642 (674) T ss_dssp CT--TCCGGGGCGGGGTTCTT-CTT-HHHHHHHHHHHHCCCCCCHHCTT-------CHHHHHHHCCCCCTTGGGSCHHHH T ss_pred CC--CCCCcccHHHHHhcchH-HHH-HHHHHHHHHHHHHHHHHHhhCCC-------CHHHHHHHHHhccccCCCcCHHHH Confidence 32 24577888898766655 344 22222111111111 11223343 458899999 89999999999999 Q sp|Q9BYF1|ACE2 570 LENVVGAKNMNVRPLLNYF 588 (805) Q Consensus 570 lenvvgaknmnvrpllnyf 588 (805) ++++.|. .++..+++.++ T Consensus 643 l~~~lG~-~~~~~~~l~~~ 660 (674) T 2O36_A 643 LRRFLGR-DPKQDAFLLSK 660 (674) T ss_dssp HHHHHSS-CCCSHHHHHHT T ss_pred HHHHhCC-CCCHHHHHHHc Confidence 9999995 78888888765 No 26 >3CE2_A Crystal structure of putative peptidase; structural genomics, UNKNOWN FUNCTION, putative; 2.6A {Chlamydophila abortus} Probab=99.92 E-value=1.1e-29 Score=244.31 Aligned_cols=507 Identities=15% Similarity=0.108 Sum_probs=330.6 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 23 EQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGD-KWSAFLKEQSTL---AQMYPLQEI-------QNL 91 (805) Q Consensus 23 eqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagd-kwsaflkeqstl---aqmyplqei-------qnl 91 (805) +..+.+++.+......+-...+.+++.+.++.+.+..+.+.+... ..+.+...-+.+ .+..+-+++ +.- T Consensus 67 ~~~~~~l~~~e~~~~~l~~~~~~a~~~~~~d~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~l~~~~~~ 146 (618) T 3CE2_A 67 ESLLSLLTTLFSIERKLNKLYVYAHLTHDQDITNQEGIADLKSITHLHTLFAEETSWVQPALTSLSESLIAQHLSAPCLA 146 (618) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTCHHHHHHHHHHHHHHHHHHHHTTTHHHHHHTSCHHHHHHHHHCSTTG T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHhhhhhHHHHhcCCHHHHHHHhcCccch Confidence 455667777777778888889999999999998876665554333 222222211111 011111111 223 Q sp|Q9BYF1|ACE2 92 TVKLQLQALQQNGSSVLSEDKSKRLNTI---LNTMSTIYST---GKVCNPD---NPQECLLLEPG-LNEIMANSLDYNER 161 (805) Q Consensus 92 tvklqlqalqqngssvlsedkskrlnti---lntmstiyst---gkvcnpd---npqeclllepg-lneimansldyner 161 (805) ..+..|+.+...+...|++++.+++..+ +..++.+|++ ..+|-+. ...+++-+.++ ...+|. +-|...| T Consensus 147 ~~~~~l~~~~~~~~~~Ls~~~e~~l~~l~~~l~~~~~~~~~l~~~~~~~~~~~~~~g~~~~l~~~~~~~~l~-~~d~~~R 225 (618) T 3CE2_A 147 PYRFYLEKIFRLSIHTGTPGEEKILASAFTPLEVASKAFSSLSDSEIPFGQATDSEGNSHPLSHALASLYMQ-STDRELR 225 (618) T ss_dssp GGHHHHHHHHTTGGGCCCHHHHHHHHHHTTGGGHHHHHHHCCCCCCSCCCEEECSSCCEEECCHHHHHHHHT-CSCHHHH T ss_pred hhHHHHHHHHHhCCccCCHHHHHHHHHhcChhHHHHHHHHHHHcccccccceeCCCCCEEECCHHHHHHHcc-CCCHHHH Confidence 4566777766667777888877665544 4466666765 4555431 12245555655 677777 8899999 Q sp|Q9BYF1|ACE2 162 LWAWESWRSEV---GKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYE 238 (805) Q Consensus 162 lwaweswrsev---gkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplye 238 (805) --+|+.|.... .....+++.+.+-+++++|+...|.+|.+|+..+++++ -+.++..++.|++++. T Consensus 226 k~~~~a~~~~~~~~~~~~~~~l~~l~~~r~~~A~~~Gy~s~~~~~l~~~~~~------------~~~~~~l~~~v~~~~~ 293 (618) T 3CE2_A 226 KTSYLAQCERYHSYRHTFANLLNGKIQAHVFYAKNKRYNSCLQAALYHNNIP------------TTVYTNLIDIVKKNSS 293 (618) T ss_dssp HHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTTTCC------------HHHHHHHHHHHHTTHH T ss_pred HHHHHHHHHHHHhcHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHhcCCC------------HHHHHHHHHHHHHchH Confidence 99999998764 35688899999999999999999999999997654431 2566678888899999 Q sp|Q9BYF1|ACE2 239 HLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQ--KPNIDVTDAMVDQAWDAQRIFKEAEKFFV 316 (805) Q Consensus 239 hlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgq--kpnidvtdamvdqawdaqrifkeaekffv 316 (805) .+|+|++.+.... |.-+-..|...| |+.+ ++.+++.++. ..+++....++. T Consensus 294 ~~~~~~~~~~~~~----------------g~~~l~~wD~~~----~~~~~~~~~~~~~~~~-------~~v~~~l~~~~~ 346 (618) T 3CE2_A 294 LITKYFSIKQRCL----------------NLKDFHFYDVYA----PLSQSKEKKYTFQEAV-------DLIYTSLSPLGT 346 (618) T ss_dssp HHHHHHHHHHHHH----------------TCSSCBGGGTTC----CSCC--CCCCCHHHHH-------HHHHHHTGGGHH T ss_pred HHHHHHHHHHHHc----------------CCCCcchhhhcC----CCCcccCCccCHHHHH-------HHHHHHhhhcCH Confidence 9999999876531 222444554444 3332 3455554431 122222222221 Q sp|Q9BYF1|ACE2 317 SVGLPNMTQGFWENSM---LTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYA-AQPFLL 392 (805) Q Consensus 317 svglpnmtqgfwensm---ltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemghiqydmaya-aqpfll 392 (805) .++- .+...|+.+.. ...||....+.|++.. .++.+|+||...+++|+.|.+||+||..+.+.+. .+|+.. T Consensus 347 ~~~~-~~~~~~~~~~~iD~~~r~~K~~ga~~~~~~----~~~~~I~~n~~~~~~~~~tl~HElGHa~h~~~~~~~~~~~~ 421 (618) T 3CE2_A 347 EYID-TLKQGLTTQGWVDKYENLNKRSGAYSSGCY----DSHPYVLLNYTGTLYDVSVIAHEGGHSMHSYFSRKHQPFHD 421 (618) T ss_dssp HHHH-HHHHHHHTSCCEECSCCTTCCCSCEEECCT----TSCCEEECCCCSSHHHHHHHHHHHHHHHHHHHHHHHSCGGG T ss_pred HHHH-HHHHHHhhcCceecccCCCCCCCccccCCC----CCCcEEEEecCCCchHHHHHHHHHHHHHHHHHHHhcCchhh Confidence 1110 01112322222 2234555667887632 2578999999999999999999999999998776 478876 Q sp|Q9BYF1|ACE2 393 RNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALT-IVGTLPFTYMLEKWRWMVF----KG- 466 (805) Q Consensus 393 rnganegfheavgeimslsaatpkhlksigllspdfqedneteinfllkqalt-ivgtlpftymlekwrwmvf----kg- 466 (805) +. ...+|+|+++..|.+-...+. ++ +.. +.+..++ ++.+.+. ++.+++...+...|..-++ .| T Consensus 422 ~~-~~~~~~E~~S~~~E~l~~~~~-~~-------~~~-~~~~~~~-~l~~~l~~~~~~~~~~~~~~~fe~~l~~~~~~~~ 490 (618) T 3CE2_A 422 AQ-YPIFLAEIASTLNEMLLMDSM-LK-------ESD-SKEEKIT-ILTRCLDTIFSTLFRQVLFASFEYDIHHAAEHGV 490 (618) T ss_dssp CS-CCGGGTTHHHHHHHHHHHHHH-HH-------HCC-CHHHHHH-HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHTTC T ss_pred cC-CCHHHHHHHHHHHHHHhHHHH-Hh-------hCC-CHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCC Confidence 64 456899999888876655442 11 111 1122344 4444444 4446666655555555555 45 Q sp|Q9BYF1|ACE2 467 EIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISN 546 (805) Q Consensus 467 eipkdqwmkkwwemkreivgvvepvphdetycdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisn 546 (805) +++.+++.+.||++.++..|+..|.+ ++..+++++..|+-..|-...|..-.+..+++.+.+|. + T Consensus 491 ~l~~~~l~~~~~~~~~~~~g~~~~~~-~~~~~~w~~~~h~~~~~Y~y~y~~~~~~a~~l~~~~~~--------------~ 555 (618) T 3CE2_A 491 PLTEEYLSSTYKNLQNEFYGEIITFD-VLSNIEWARIPHFYYNFYVYQYATGIIAALCFLEKILN--------------N 555 (618) T ss_dssp CCCHHHHHHHHHHHHHHHHTTTCBCC-TTGGGGGGGSCGGGCSSCTHHHHHHHHHHHHHHHHHHT--------------T T ss_pred CCCHHHHHHHHHHHHHHHhCCCCCCc-cccccHhhccchhhcchhcHHHHHHHHHHHHHHHHHHh--------------C Confidence 67778999999999999999877665 35566777777764222222222223444555444432 3 Q sp|Q9BYF1|ACE2 547 STEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKN 601 (805) Q Consensus 547 steagqklfnmlrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnkn 601 (805) ..++|.++.++|+.|.+.||.-.++. .|.......++..+|.|+..||+..++. T Consensus 556 ~~~~~~~~~~~L~~G~s~~~~el~~~-~g~~~~~~~~~~~~~~~l~~~l~~~~~~ 609 (618) T 3CE2_A 556 EDNALNSYLNFLKSGGSDFPLEILKK-SGLDMGTVEPIQKAFCFIEKKIQELSSL 609 (618) T ss_dssp CTTHHHHHHHHHTTTTSSCHHHHHHH-TTCCTTSSHHHHHHHHHHHHHHHHHHTT T ss_pred CchHHHHHHHHHHccCCCCHHHHHHH-cCCCCCCCHHHHHHHHHHHHHHHHHHHH Confidence 46789999999999999999999984 9999888999999999999999988764 No 27 >2O3E_A Neurolysin (E.C.3.4.24.16); thermolysin-like domain, substrate-binding channel, HYDROLASE; 2.2A {Rattus norvegicus} Probab=99.90 E-value=9.4e-29 Score=246.41 Aligned_cols=515 Identities=14% Similarity=0.179 Sum_probs=346.7 Template_Neff=9.500 Q sp|Q9BYF1|ACE2 31 KFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMY-------------PLQEIQNLTVKLQL 97 (805) Q Consensus 31 kfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmy-------------plqeiqnltvklql 97 (805) .+......+-...+.++|-+.++.+++..+..+.+..+++++..+..+-...| .+.+.+...++..+ T Consensus 68 ~ld~~~~~l~~~~~~~~~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~ly~~l~~~~~~~~~~~ld~e~~~~l~~~~ 147 (678) T 2O3E_A 68 VLADIEVTYIVERTMLDFPQHVSSDREVRAASTEADKKLSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSI 147 (678) T ss_dssp HHHHHHHHHHHHHHHHHSHHHHCSCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHHHHCCTTSSCHHHHHHHHHHH T ss_pred HHHHhhhhhHHHHHHHHHHHHhCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHHhcccHhhCCHHHHHHHHHHH Confidence 33333333556677888999999999999999999999999988875544444 35555666778888 Q sp|Q9BYF1|ACE2 98 QALQQNGSSVLSEDKSKRLNTI---LNTMSTIYSTGKVCNPD-------------------------NPQECLLL-EPGL 148 (805) Q Consensus 98 qalqqngssvlsedkskrlnti---lntmstiystgkvcnpd-------------------------npqeclll-epgl 148 (805) +.++++|.. |++++.+++..+ +..++..|+....|... .+ .++.+ .|.+ T Consensus 148 ~~~~~~G~~-L~~~~~~~~~~l~~~i~~l~~~f~~~~~~~~~~~~~~~~~l~g~p~~~~~~~~~~~~~g-~~~~l~~~~~ 225 (678) T 2O3E_A 148 KMGKRNGLH-LSEHIRNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDEDK-YKVTLKYPHY 225 (678) T ss_dssp HHHHHTTTT-SCHHHHHHTHHHHHHHHHHHHHHHHHHHHCCCEEEEETTTTTTCCHHHHHTSCBCSSSE-EEEESSHHHH T ss_pred HHHHHcCCC-CCHHHHHHHHHHHHHHHHHHHHHHHhcCCCCcceeCCHHHHcCCCHHHHHHHhcCCCCC-cEEEcCCccH Confidence 899999975 777666666544 44555556666665421 12 23444 5678 Q sp|Q9BYF1|ACE2 149 NEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEH 228 (805) Q Consensus 149 neimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedveh 228 (805) ..+|+++-|...|..+|+.|....++..++++++.+.+++++|+...|++|.+||..++.+ ++..++.+-.+. T Consensus 226 ~~il~~~~d~~~R~~~~~a~~~~~~~~~~~~l~~ll~lr~~~A~~lGy~s~~~~~l~~~~~-------~s~~~v~~~l~~ 298 (678) T 2O3E_A 226 FPVMKKCCVPETRRKMEMAFHTRCKQENTAILQQLLPLRAQVAKLLGYNTHADFVLELNTA-------KSTSRVAAFLDD 298 (678) T ss_dssp HHHHHHCCCHHHHHHHHHHHTTTTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSTT-------CSHHHHHHHHHH T ss_pred HHHHHhCCCHHHHHHHHHHhhcCCchhHHHHHHHHHHHHHHHHHHhCCCCHHHHHhccCCC-------CCHHHHHHHHHH Confidence 8999999999999999999998777788999999999999999999999999999876643 233445555666 Q sp|Q9BYF1|ACE2 229 TFEEIKPLYEHLHAYVRAKLMNAYPSY-ISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRI 307 (805) Q Consensus 229 tfeeikplyehlhayvraklmnaypsy-ispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqri 307 (805) ..+.++|++++++++++.......+.+ .++.+.+ ..|...|-...+. +...+++++.+.+-+....+ T Consensus 299 l~~~~~p~~~~~~~~l~~~~~~~~~~~g~~~~~~l----------~~wD~~~~~~~~~--~~~~~~~~~~~~~yf~~~~v 366 (678) T 2O3E_A 299 LSQKLKPLGEAEREFILSLKKKECEERGFEYDGKI----------NAWDLHYYMTQTE--ELKYSVDQESLKEYFPIEVV 366 (678) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCSSC----------CHHHHHHHHHHHH--HHHTCCCHHHHGGGCBHHHH T ss_pred HHHHhHHHHHHHHHHHHHHHHHHhHHcCCCcCCCC----------CcccHHHHHHHHH--HhcCCCCHHHHHhhCCHHHH Confidence 778899999999999987443322211 1111122 3455555554433 22455656666655555444 Q sp|Q9BYF1|ACE2 308 ----FKEAEKFFVSVGLPNM-TQGFWENSMLT---------------------DPGNVQKAVCHPTAWDL--GKG----D 355 (805) Q Consensus 308 ----fkeaekffvsvglpnm-tqgfwensmlt---------------------dpgnvqkavchptawdl--gkg----d 355 (805) ++-++++| .+++... ...+|..+... .||.-..+.|.+...+. ..| . T Consensus 367 ~~~l~~~~~~~f-g~~~~~~~~~~~W~~~v~~~~v~~~~~~~~~g~~ylD~~~r~~K~~~~~~~~~~~~~~~~~g~~~~p 445 (678) T 2O3E_A 367 TEGLLSIYQELL-GLSFEQVPDAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMS 445 (678) T ss_dssp HHHHHHHHHHHH-TEEEEECTTCCCSSTTCEEEEEEETTTCCEEEEEEEECSCCTTSCCSCEEEEEECCBBCTTSCBCCE T ss_pred HHHHHHHHHHHh-CCEEEECCCCCCccCCCeEEEEEECCCCcEEEEEEEECCCCCCCCCCcceeeecCCccCCCCCeeCe Confidence 34444444 4444332 23457665541 23332233343322211 111 3 Q sp|Q9BYF1|ACE2 356 FRILMCTKV----------TMDDFLTAHHEMGHIQYDMAYAA-QPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLL 424 (805) Q Consensus 356 frilmctkv----------tmddfltahhemghiqydmayaa-qpfllrnganegfheavgeimslsaatpkhlksigll 424 (805) +++++|... +.+|+.|.+||+||..+.+.... +|.+...+...+|+|+.+.+|...+..|.+|+.++.. T Consensus 446 ~~~i~~n~~~~~~~~~~ll~~~~~~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~l~E~~~~~~~~L~~l~~~ 525 (678) T 2O3E_A 446 VAALVVNFSQPVAGRPSLLRHDEVETYFHEFGHVMHQICAQTDFARFSGTNVERDFVEVPSQMLENWVWDVDSLRKLSKH 525 (678) T ss_dssp EEEEECCCCCCBTTBCCBCCHHHHHHHHHHHHHHHHHHHCCBSSGGGSTTCSCTTTTTHHHHHHHGGGGCHHHHHHHCCC T ss_pred EEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHhcCCcHHHcCCcccchhhchhHHHhHHhhcCHHHHHHHhcc Confidence 567877653 89999999999999999877652 3333333467899999999999999999999999876 Q sp|Q9BYF1|ACE2 425 SPDFQEDNETEINFLLK-----QALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCD 499 (805) Q Consensus 425 spdfqedneteinfllk-----qaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycd 499 (805) ..+-+.-.+..++.+++ +++.++..+++. .++. .++.+.. . ..-+.||++.++..|+ |++.+ .+. T Consensus 526 ~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~l~~a-~~d~---~l~~~~~-~-~~~~~~~~~~~~~~g~--~~~~~--~~~ 595 (678) T 2O3E_A 526 YKDGHPITDELLEKLVASRLVNTGLLTLRQIVLS-KVDQ---SLHTNAT-L-DAASEYAKYCTEILGV--AATPG--TNM 595 (678) T ss_dssp SSSCCCCCHHHHHHHHHTTTTTHHHHHHHHHHHH-HHHH---HHTTCTT-S-CHHHHHHHHCCCCCSS--CCCTT--CCG T ss_pred CCCCCCCCHHHHHHHHHhhhhhHHHHHHHHHHHH-HHHH---HHhcCCC-c-cHHHHHHHHHHHHHCC--CCCCC--CCC Confidence 65544445667888888 788888888776 4454 3455542 2 2357888877777786 43322 456 Q sp|Q9BYF1|ACE2 500 PASLFHVSNDYSF--IRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFN-MLRLGKSEPWTLALENVVGA 576 (805) Q Consensus 500 paslfhvsndysf--iryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfn-mlrlgksepwtlalenvvga 576 (805) +.+..|..++|.+ ..|........++-+++|+. .||+ +.++|+++.+ +|..|.+.||.-.++.+.|. T Consensus 596 ~~~~~hl~~~y~~~Yy~Yl~s~vla~~i~~~~~~~---~~~~-------~~~~g~~~~~~~l~~G~s~~~~e~l~~~~g~ 665 (678) T 2O3E_A 596 PATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFKK---EGIM-------NPEVGMKYRNLILKPGGSLDGMDMLQNFLQR 665 (678) T ss_dssp GGGCTTSSSSCTTCTTHHHHHHHHHHHHCCCCCCH---HCTT-------CHHHHHHHCCCCCTTGGGSCHHHHHHHHHTS T ss_pred cccHHHHHccchHHHHHHHHHHHHHHHHHHHHHHh---cCCC-------CHHHHHHHHHHhcccCCCCCHHHHHHHHhCC Confidence 7888898776644 23333333444444443321 2333 3589999998 99999999999999999995 Q sp|Q9BYF1|ACE2 577 KNMNVRPLLNYF 588 (805) Q Consensus 577 knmnvrpllnyf 588 (805) .+++.+++.|+ T Consensus 666 -~~~~~~ll~~~ 676 (678) T 2O3E_A 666 -EPNQKAFLMSR 676 (678) T ss_dssp -CCCSHHHHHHH T ss_pred -CCCHHHHHHHc Confidence 79999988875 No 28 >5LV0_A Neurolysin, mitochondrial (E.C.3.4.24.16), GLY-VAL-VAL amyloid; PROTEASE, MITOCHONDRIA, HYDROLASE, amyloid-beta; 2.7A {Homo sapiens} Probab=99.89 E-value=6.2e-28 Score=240.22 Aligned_cols=504 Identities=15% Similarity=0.198 Sum_probs=338.6 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 41 YQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP-------------LQEIQNLTVKLQLQALQQNGSSV 107 (805) Q Consensus 41 yqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp-------------lqeiqnltvklqlqalqqngssv 107 (805) .....+.|.++++.+++..+..+.+..++++|..+..+-..+|. +.+-+...++..++.++.+|.. T Consensus 83 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~l~~e~~~~l~~~l~~~~~~G~~- 161 (686) T 5LV0_A 83 VERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMSMRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLH- 161 (686) T ss_dssp HHHHHHHSHHHHCSCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHHHHHHSCTTTSCHHHHHHHHHHHHHHHHTTTT- T ss_pred hHHHHhhhHHhhCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHHhccchhcCCHHHHHHHHHHHHHHHHcCCC- Confidence 44556788899998888888888899999999888765455553 2233334456666777888876 Q sp|Q9BYF1|ACE2 108 LSEDKSKRLNTI---LNTMSTIYSTGKVCNPD-------------------------NPQECLLL-EPGLNEIMANSLDY 158 (805) Q Consensus 108 lsedkskrlnti---lntmstiystgkvcnpd-------------------------npqeclll-epglneimansldy 158 (805) |++++.+++..+ +..+++.|+....|... ++ .++-+ .|.+..+|+++-|. T Consensus 162 L~~~~~~~~~~l~~~~~~l~~~f~~~~~~~~~~~~~~~~~l~g~p~~~~~~~~~~~~~~-~~~~l~~~~~~~~l~~~~d~ 240 (686) T 5LV0_A 162 LPEQVQNEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDDK-YKITLKYPHYFPVMKKCCIP 240 (686) T ss_dssp SCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECTTTTTTCCHHHHHHSCBCTTSC-EEEESSHHHHHHHHHHCCCH T ss_pred CCHHHHHHHHHHHHHHHHHHHHHHHccCCCCceeeCCHHHHcCCCHHHHHHHhccCCCC-eEEEcCCccHHHHHHhCCCH Confidence 455555666665 66667777776665421 11 23333 46788899999999 Q sp|Q9BYF1|ACE2 159 NERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYE 238 (805) Q Consensus 159 nerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedvehtfeeikplye 238 (805) ..|-.+|+.|....++...+++++.+.+++++|+...|.+|.+||...+.+. +...+.+-++...+.++|+++ T Consensus 241 ~~R~~~~~a~~~~~~~~n~~~l~~ll~lR~~~A~~lG~~s~~~~~l~~~~~~-------~~~~v~~~l~~l~~~~~p~~~ 313 (686) T 5LV0_A 241 ETRRRMEMAFNTRCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEMNTAK-------STSRVTAFLDDLSQKLKPLGE 313 (686) T ss_dssp HHHHHHHHHHTTTTHHHHHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSTTC-------SHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHhcCCchhHHHHHHHHHHHHHHHHHHhCCCCHHHHHhhccCCC-------CHHHHHHHHHHHHHHhHHHHH Confidence 9999999999887666888999999999999999999999999998776543 233444445556678899999 Q sp|Q9BYF1|ACE2 239 HLHAYVRAKLMNAYPSYISP-IGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVS 317 (805) Q Consensus 239 hlhayvraklmnaypsyisp-igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvs 317 (805) .+++++++......+.+-.+ .+.+ ..|...|-+.... +..++++++.+.+.+....+++.+..++-+ T Consensus 314 ~~~~~l~~~~~~~~~~~g~~~~~~l----------~~wD~~~~~~~~~--~~~~~~~~~~~~~yf~~~~v~~~~~~~~~~ 381 (686) T 5LV0_A 314 AEREFILNLKKKECKDRGFEYDGKI----------NAWDLYYYMTQTE--ELKYSIDQEFLKEYFPIEVVTEGLLNTYQE 381 (686) T ss_dssp HHHHHHHHHHHHHHHHHTCCCCSSC----------BTTTHHHHHHHHH--HHHHCCCHHHHGGGCBHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHchhCCCCcCCCC----------ChhhHHHHHHHHH--HHhcCCCHHHHHhhCCHHHHHHHHHHHHHH Confidence 99999976444322111001 1111 2344444443332 235667777777777777777777777666 Q sp|Q9BYF1|ACE2 318 -VGLPNM---TQGFWENSML---------------------TDPGNVQKAVCHPTAWDLGKG-----DFR-----ILMC- 361 (805) Q Consensus 318 -vglpnm---tqgfwensml---------------------tdpgnvqkavchptawdlgkg-----dfr-----ilmc- 361 (805) .|+.-. ...+|.++.. ..+|.-..+.|.+ +..+ +.+ +++| T Consensus 382 lfg~~~~~~~~~~~w~~~v~~~~v~~~~~~~~lg~~~lD~~~r~~K~~~a~~~~----~~~~~~~~~~~~~~p~~~i~~n 457 (686) T 5LV0_A 382 LLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFG----LQPGCLLPDGSRMMAVAALVVN 457 (686) T ss_dssp HHTEEEEEETTCCCSSTTCEEEEEEETTTCCEEEEEEEECSCCTTSCCSCEEEE----EECCCBCTTSSBCCEEEEEECC T ss_pred HHCcEEEECCCCCccCCCceEEEEEECCCCcEEEEEEEECCCCCCCCCCcceee----eeCCccCCCCCeeCeEEEEEec Confidence 665433 2335665533 1234333344443 3222 122 4554 Q sp|Q9BYF1|ACE2 362 ---------TKVTMDDFLTAHHEMGHIQYDMAYAA-QPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQED 431 (805) Q Consensus 362 ---------tkvtmddfltahhemghiqydmayaa-qpfllrnganegfheavgeimslsaatpkhlksigllspdfqed 431 (805) +.++++|+.|.+||+||..+.+.+.. +|.+...+....|+|+.+.+|..-+..|++|+.++....+-+.- T Consensus 458 ~~~~~~~~~~~l~~~~v~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~~~E~~~~~~~~L~~l~~~~~~~~~~ 537 (686) T 5LV0_A 458 FSQPVAGRPSLLRHDEVRTYFHQFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPI 537 (686) T ss_dssp CCCCBTTBCCBCCHHHHHHHHHHHHHHHHHHHCCCSSSTTSTTCSCTTTTTHHHHHHHGGGGCHHHHHHHCCCTTTCCCC T ss_pred CCCCCCCCCCCCChHHHHHHHHHHHHHHHHHHhcCCcHHHcCCCccchhchHhHHHhHHhhcCHHHHHHHhhhcCCCCCC Confidence 56699999999999999999987764 56666667889999999999999999999999988665544333 Q sp|Q9BYF1|ACE2 432 NETEINFLLKQ-----ALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHV 506 (805) Q Consensus 432 neteinfllkq-----altivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetycdpaslfhv 506 (805) .+..++.+++. ++.++..+++. +++. .++.+.. ....+.|+++.++..|+ |.+. ....+.+..|. T Consensus 538 ~~~~~~~l~~~~~~~~~~~~~~~l~~~-~~d~---~l~~~~~--~~~~~~~~~~~~~~~g~--~~~~--~~~~~~~~~hl 607 (686) T 5LV0_A 538 ADDLLEKLVASRLVNTGLLTLRQIVLS-KVDQ---SLHTNTS--LDAASEYAKYCSEILGV--AATP--GTNMPATFGHL 607 (686) T ss_dssp CHHHHHHHHHGGGTTHHHHHHHHHHHH-HHHH---HHTTCCS--SCHHHHHHHHCCCCCCS--BCCT--TCCSGGGCGGG T ss_pred CHHHHHHHHHhhhHhHHHHHHHHHHHH-HHHH---HHhcCCC--ccHHHHHHHHHHHHhCC--CCCC--CCCCccccHHH Confidence 45667777776 67777777655 5664 3455542 23578899987887785 3322 23567777888 Q sp|Q9BYF1|ACE2 507 SNDYSFIRYYTRTLYQFQFQEALC-QAAKHEGPLHKCDISNSTEAGQKLFN-MLRLGKSEPWTLALENVVGAKNMNVRPL 584 (805) Q Consensus 507 sndysfiryytrtlyqfqfqealc-qaakhegplhkcdisnsteagqklfn-mlrlgksepwtlalenvvgaknmnvrpl 584 (805) ..+|.. .||.. ++..-+...+. +..+..||+ +.++|.++.+ +|..|.+.+|.-.++.+.|. .++..++ T Consensus 608 ~~~y~~-~yY~Y-l~s~~~A~~i~~~~f~~~~~~-------~~~~g~~~~~~~L~~G~s~~~~e~l~~~~G~-~~~~~~l 677 (686) T 5LV0_A 608 AGGYDG-QYYGY-LWSEVFSMDMFYSCFKKEGIM-------NPEVGMKYRNLILKPGGSLDGMDMLHNFLKR-EPNQKAF 677 (686) T ss_dssp TTTCTT-CTTHH-HHHHHHHHHHCCCCCTTSCTT-------CHHHHHHHCCCCCTTTTSSCHHHHHHHHHSS-CCCSHHH T ss_pred Hccchh-HHHHH-HHHHHHHHHHHHHHHHhcCCC-------CHHHHHHHHHHhhhcCCCCCHHHHHHHHhCC-CCCHHHH Confidence 766653 44421 22211111111 112222332 3689999999 99999999999999999994 7999999 Q sp|Q9BYF1|ACE2 585 LNYFE 589 (805) Q Consensus 585 lnyfe 589 (805) +.++. T Consensus 678 l~~~~ 682 (686) T 5LV0_A 678 LMSRG 682 (686) T ss_dssp HHHHT T ss_pred HHHcC Confidence 88864 No 29 >1S4B_P Thimet oligopeptidase (E.C.3.4.24.15); Zinc metallopeptidase domain, HYDROLASE; 2.0A {Homo sapiens} SCOP: d.92.1.5 Probab=99.88 E-value=1.6e-27 Score=236.83 Aligned_cols=516 Identities=16% Similarity=0.187 Sum_probs=326.3 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 26 KTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPL-------------QEIQNLT 92 (805) Q Consensus 26 ktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmypl-------------qeiqnlt 92 (805) +..+..+......+-...+.+.|.++++.+++..+....+-.++++|..+..+-...|.+ .+.+... T Consensus 47 ~~~i~~~d~~~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~~~~~ld~e~~r~ 126 (674) T 1S4B_P 47 ESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARY 126 (674) T ss_pred HHhHHHHHHHHHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHcCCHHHHHHHHHHHhCcchhhCCHHHHHH Confidence 344556666666677888899999999999999999999999999999887666666652 2222333 Q sp|Q9BYF1|ACE2 93 VKLQLQALQQNGSSVLSEDKSKRLNTIL---NTMSTIYSTGKVCNPDN------------------------PQECLLLE 145 (805) Q Consensus 93 vklqlqalqqngssvlsedkskrlntil---ntmstiystgkvcnpdn------------------------pqecllle 145 (805) ++..+..++.+|.. |++++.+++..+. ..++..|.....|.... ...++.+. T Consensus 127 l~~~l~~~~~~G~~-L~~~~~~~~~~l~~~i~~l~~~f~~~~~~~~~~~~~~~~~l~g~p~~~~~~~~~~~~~~~~~~l~ 205 (674) T 1S4B_P 127 LERLIKLGRRNGLH-LPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGKLKVTLK 205 (674) T ss_pred HHHHHHHHHHcCCC-CCHHHHHHHHHHHHHHHHHHHHHHHhccccccccEEeHHHHcCCCHHHHHHHHHHHcCCeEEEcC Confidence 45555666777754 6666656665554 44677777777665321 11234444 Q sp|Q9BYF1|ACE2 146 -PGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIE 224 (805) Q Consensus 146 -pglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqlie 224 (805) |.+..+|+++-|...|-.+|+.|+...++...+++++.+.+++++|+...|.+|.+||..++.+. +..++.+ T Consensus 206 ~~~~~~il~~~~d~~~R~~~~~a~~~~~~~~~~~~l~~l~~lR~~~A~~lGy~s~~~~~l~~~~~~-------~~~~v~~ 278 (674) T 1S4B_P 206 YPHYFPLLKKCHVPETRRKVEEAFNSRCKEENSAILKELVTLRAQKSRLLGFHTHADYVLEMNMAK-------TSQTVAT 278 (674) T ss_pred CccHHHHHhcCCCHHHHHHHHHHHHccCCcccHHHHHHHHHHHHHHHHHhCCCCHHHHHccccCCC-------CHHHHHH Confidence 67899999999999999999999987777889999999999999999999999999998765442 2223333 Q sp|Q9BYF1|ACE2 225 DVEHTFEEIKPLYEHLHAYVRAKLM---NAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQA 301 (805) Q Consensus 225 dvehtfeeikplyehlhayvraklm---naypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqa 301 (805) -.+...+.++|+|+..+++++.... +.+.. +..+-+ ..|...|-...+... ...+..+.+... T Consensus 279 ~l~~l~~~~~p~~~~~~~~l~~~~~~~~~~~g~--~~~~~l----------~~wD~~y~~~~~~~~--~~~~~~~~i~~y 344 (674) T 1S4B_P 279 FLDELAQKLKPLGEQERAVILELKRAECERRGL--PFDGRI----------RAWDMRYYMNQVEET--RYCVDQNLLKEY 344 (674) T ss_pred HHHHHHHHhHHHHHHHHHHHHHHHHHHHHhcCC--CCCCCC----------ChhcHHHHHHHHHHh--cCCCCHHHHHhh Confidence 3445567889999999888775322 22210 001111 234444444333211 223333333332 Q sp|Q9BYF1|ACE2 302 WD----AQRIFKEAEKFFVSVGLPN---MTQGFWENSML-----------------TD----PGNVQKAVCHPTAWDL-- 351 (805) Q Consensus 302 wd----aqrifkeaekffvsvglpn---mtqgfwensml-----------------td----pgnvqkavchptawdl-- 351 (805) .. ...+++.++++| |+.. ....+|.++.. .| ||.-..+.|.+...+. T Consensus 345 f~~~~~~~~l~~~~~~~f---g~~~~~~~~~~~W~~~v~~~~v~d~~~~~~lg~~~lD~~~r~~K~~~a~~~~~~~~~~~ 421 (674) T 1S4B_P 345 FPVQVVTHGLLGIYQELL---GLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCLR 421 (674) T ss_pred CCHHHHHHHHHHHHHHHh---CCEEEECCCCCcccCCceEEEEEeCCCCcEEEEEEEECCCCCCCCCCcceeeEecCccC Confidence 21 245666666666 4322 24456777654 22 2222234444332211 Q sp|Q9BYF1|ACE2 352 --GKGD--FRIL----------MCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGAN--EGFHEAVGEIMSLSAATP 415 (805) Q Consensus 352 --gkgd--fril----------mctkvtmddfltahhemghiqydmayaaqpfllrngan--egfheavgeimslsaatp 415 (805) |+.. ..++ .|+.++.+|+.|.+||+||..+.+.+..++. ...|++ -.|+|+.+.+|...+..| T Consensus 422 ~~~~~~~p~~~l~~n~~~~~~~~~~ll~~~~v~tl~HE~GHalh~~l~~~~~~-~~~g~~~~~d~~E~~S~~~E~~~~~~ 500 (674) T 1S4B_P 422 QDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFA-MFSGTHVERDFVEAPSQMLENWVWEQ 500 (674) T ss_pred CCCCeeccEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHhCCCch-hhcCCCCCCcccccchHHHHHhhcCH Confidence 1000 0122 6778889999999999999999998876544 456655 799999999999999999 Q sp|Q9BYF1|ACE2 416 KHLKSIGLLSPDFQEDNETEINFLLKQA-----LTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEP 490 (805) Q Consensus 416 khlksigllspdfqedneteinfllkqa-----ltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvep 490 (805) ++|+.++.-..+-+.-.+..++.+++.. +.++..+.+ ..++.+ ++.+. ..++.+.||++..+..|+ | T Consensus 501 ~~L~~l~~~~~~~~~l~~~~~~~l~~~~~~~~~l~~~~~l~~-~~~d~~---l~~~~--~~~~~~~~~~l~~~~~g~--~ 572 (674) T 1S4B_P 501 EPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVL-AKVDQA---LHTQT--DADPAEEYARLCQEILGV--P 572 (674) T ss_pred HHHHHHhhccCCCCCCCHHHHHHHHHhhcHHHHHHHHHHHHH-HHHHHH---HhcCC--CCcHHHHHHHHHHHHcCC--C Confidence 9999887543221111233455554322 222222222 222322 23222 256788899999998887 3 Q sp|Q9BYF1|ACE2 491 VPHDETYCDPASLFHVSNDYSF--IRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWT 567 (805) Q Consensus 491 vphdetycdpaslfhvsndysf--iryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgksepwt 567 (805) .+.+ ...+.+..|...+|.+ ..|....+..+++-.+.| +..||+ +.++|.++. ++|..|.+.+|. T Consensus 573 ~~~~--~~~~~~~~h~~~~y~~~yysYl~s~v~A~~i~~~~~---~~~~~~-------~~~~g~~~~~~~L~~G~s~~~~ 640 (674) T 1S4B_P 573 ATPG--TNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRF---KQEGVL-------NSKVGMDYRSCILRPGGSEDAS 640 (674) T ss_pred CCCC--CCchhhhHHHHccchHHHHHHHHHHHHHHHHHHHHH---hhhCCC-------CHHHHHHHHHHhcccCCCCCHH Confidence 3222 3466778888755544 333333333444322222 223443 358899998 899999999999 Q sp|Q9BYF1|ACE2 568 LALENVVGAKNMNVRPLLNYF 588 (805) Q Consensus 568 lalenvvgaknmnvrpllnyf 588 (805) -.++++.| .+++..+++.++ T Consensus 641 e~l~~~lG-~~~~~~~~l~~~ 660 (674) T 1S4B_P 641 AMLRRFLG-RDPKQDAFLLSK 660 (674) T ss_pred HHHHHHhC-CCCCHHHHHHHc Confidence 99999988 568888887665 No 30 >5L44_A K-26 dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase, metalloprotease, K-26 tripeptide; HET: K26, SO4; 1.75A {Astrosporangium hypotensionis K-26} Probab=99.77 E-value=4.9e-23 Score=205.45 Aligned_cols=512 Identities=16% Similarity=0.122 Sum_probs=318.9 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 28 FLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP---------LQEIQNLTVKLQLQ 98 (805) Q Consensus 28 fldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp---------lqeiqnltvklqlq 98 (805) ++..+..-...+..-.+++++.+.++.+++..+..+.+..+.+.+..+.......|. +.+-+...++..++ T Consensus 76 ~i~~le~~~~~l~~~~~~~~~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~l~~e~~~~l~~~l~ 155 (683) T 5L44_A 76 TVAALERSGQVLTRVSAVFFNQSSSDTNPTVQEIQKQIIPKLTQHGDAIHLNRPLFARIKQISPDGLDAEQAWLLERYVT 155 (683) T ss_dssp CCCHHHHCCHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHTCCCTTCCHHHHHHHHHHHH T ss_pred HHHHHHHhhHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHcccCCCHHHHHHHHHHHH Confidence 344444444555556778888888887888888888888888888766655444443 22223445556677 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSED--KSKRLNTILNTMSTIYS----TGK----VCN---------PDN--------------PQ-ECLLL 144 (805) Q Consensus 99 alqqngssvlsed--kskrlntilntmstiys----tgk----vcn---------pdn--------------pq-eclll 144 (805) .+.++|...++++ +-..++..+..++..|+ +.+ +|- |.. +. .++-+ T Consensus 156 ~~~~~G~~l~~~~~e~~~~l~~~~~~l~~~f~~n~~~~~~~~~~~~~~~~~l~glp~~~~~~~~~~~~~~~~~G~~~i~l 235 (683) T 5L44_A 156 DFVRAGAELGAGDQERLKALNEELSTLSTRFEQNLLAHTNASAVIVDDVAQLDGLSDDSVKAAAETAKSRGLPGKYVIPL 235 (683) T ss_dssp HHHHTTTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCEEESCGGGGTTSCHHHHHHHHHHHHHTTCTTSEEECC T ss_pred HHHHhcccCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccceecCCHHHHCCCCHHHHHHHHHHHHHcCCCCCeEEec Confidence 7888888877765 34445666777778887 332 332 110 11 23444 Q sp|Q9BYF1|ACE2 145 E-PGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLI 223 (805) Q Consensus 145 e-pglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqli 223 (805) . |....+|.++-|...|-.+|++|.....+...+++++.+-+++++|+...|++|.+||-.++.+... T Consensus 236 ~~~~~~~il~~~~d~~~Rk~~~~a~~~~~~~~n~~~l~~lv~~R~~~A~~lGy~s~a~~~l~~~~~~~~----------- 304 (683) T 5L44_A 236 VLPTGQPGLAELTDRALRERIHRASIQRGVPDNEELIVRIATLRAERAKLLGYPTHAAYVVADQTAPTT----------- 304 (683) T ss_dssp CSSSSCGGGGTCCCHHHHHHHHHHHHTTTTTTTHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSSSCCH----------- T ss_pred CCCchHHHHHhCCCHHHHHHHHHHHHhcCCcchHHHHHHHHHHHHHHHHHhCCCCHHHHHcCCCCCCCH----------- Confidence 4 6788899999999999999999997655678899999999999999999999999999877665421 Q sp|Q9BYF1|ACE2 224 EDVEHTFEE-IKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAW 302 (805) Q Consensus 224 edvehtfee-ikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqaw 302 (805) ++|.....+ +++++..+|++++.+... + |+ --..|.-.|-....... .+.+..+.+..-. T Consensus 305 ~~v~~~L~~l~~~~~p~~~~~~~~l~~~-~---------------~~-~l~~wD~~y~~~~~~~~--~~~~~~~~~~~yf 365 (683) T 5L44_A 305 EAVTEMLGKLTPPAVANAHREADELREQ-A---------------GH-DLEPWDWSFYAEKVLKE--RYAIDGRQMRPYF 365 (683) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHH-H---------------SS-CCCGGGHHHHHHHHHHH--HHCCCHHHHGGGC T ss_pred HHHHHHHHHhhHHhHHHHHHHHHHHHHH-c---------------CC-CCCccCHHHHHHHHHHH--hhCCChhHhHhhc Confidence 223222222 346666778887754321 1 11 01223332322211111 1111111111111 Q sp|Q9BYF1|ACE2 303 DAQ-----RIFKEAEKFF--------------------VSVGL-PNMTQGFWENSMLTDPGNVQKAVCHPTAWD--LGKG 354 (805) Q Consensus 303 daq-----rifkeaekff--------------------vsvgl-pnmtqgfwensmltdpgnvqkavchptawd--lgkg 354 (805) ... .+|.-++++| .-.+- ......+|-. ....+|....+.|++..-. .... T Consensus 366 ~~~~v~~~~l~~~~~~lfg~~~~~~~~~~~w~~~v~~~~v~~~~~~~lg~~~lD-~~~r~~K~~~~~~~~~~~~~~~~~~ 444 (683) T 5L44_A 366 ELDRVLRDGVFHAATLLYGITFTERPDLVGYHPDVRVFEVFNEDGSQLGLFLGD-YYARPSKRGGAWMNSLVKQSTLEGT 444 (683) T ss_dssp BHHHHCCCCCCHHHHHHHCCEEEECTTSCCSSTTCEEEEEECTTSCEEEEEEEE-EECCTTSCSSCEEEEEECCBTTTTB T ss_pred CHHHHHHHHHHHHHHHHhCCEEEECCCCCCccCCeEEEEEEcCCCCEEEEEEEe-ccCCCCCCCCccccccccccccCCC Confidence 111 1222222221 00000 0111113322 1223344444566653210 0134 Q sp|Q9BYF1|ACE2 355 DFRILMCTK-----------VTMDDFLTAHHEMGHIQYDMAYA-AQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIG 422 (805) Q Consensus 355 dfrilmctk-----------vtmddfltahhemghiqydmaya-aqpfllrnganegfheavgeimslsaatpkhlksig 422 (805) ...|.+|.. .+.+|+.|.+||+||..+.+... .+|.+.+.+....|.|+.+.+|.+-+..|.+|++++ T Consensus 445 ~p~v~l~~~~~~~~~~~~~l~~~~~v~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~~~E~~~~~~~~L~~~~ 524 (683) T 5L44_A 445 RPVVVNNLNIAKPPAGEPTLMTFEEVNTMFHEFGHALHGLFSEVHYPRFSGTAVPRDFVEYPSQVNEMWAVWPSVLANYA 524 (683) T ss_dssp CCEEEEEEEECCCCTTCCCBCCHHHHHHHHHHHHHHHHHHTCCCSSGGGCTTCSCHHHHHHHHHHHTHHHHCHHHHHHHC T ss_pred CCEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHcCCCCccccCCCCCchhhccchHHhHhhhcCHHHHHHHh Confidence 577888887 89999999999999999988765 577777777889999999999999999999999987 Q sp|Q9BYF1|ACE2 423 LLSPDFQEDNETEINFLLK-----QALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 423 llspdfqedneteinfllk-----qaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) ....+-+.-.+..++.++. +++.++..+++. .++.+ ++.+..+.+.+..-||+...+. |+.-|... . . T Consensus 525 ~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~l~~a-~~D~~---lh~~~~~~~~~~~~~~~~~~~~-g~~~~~~~-~-~ 597 (683) T 5L44_A 525 RHWQTGDPMPKDLLDRMLKSQKYNQGYKTVEYLAAT-LLDWS---WHTFQTPPENALTFEHEALTTA-GVDLKLVP-P-R 597 (683) T ss_dssp BCTTTCCBCCHHHHHHHHHTTSTTHHHHHHHHHHHH-HHHHH---HTSCSSCCSCHHHHHHHHHHHT-TCCBTTBC-C-S T ss_pred hccCCCCCCCHHHHHHHHHhhchhHHHHHHHHHHHH-HHHHH---HhcCCCCCccHHHHHHHHHHHh-CCCCCCCC-C-c Confidence 6643222224455666654 567777777775 66655 3444444466777788866665 76544321 1 2 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSN-DYS--FIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWTLALENV 573 (805) Q Consensus 498 cdpaslfhvsn-dys--firyytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgksepwtlalenv 573 (805) ..+.+..|+.. +|. +..|....+..++.-+++|++ ||+ +.++|+++. .+|+.|.+.||.-.++.. T Consensus 598 ~~~~~~~hi~~~~y~~~yy~Yl~s~v~a~~i~~~f~~~----~~~-------~~~~g~~~r~~iL~~G~s~~~~e~l~~f 666 (683) T 5L44_A 598 YRSTYFAHIWSSGYSAGYYSYIWSEVLDADTVDWFHEN----GGL-------LRENGDTFRQKLLSKGGSVDPMTAFQSF 666 (683) T ss_dssp SCGGGCHHHHTSSCTTCTTHHHHHHHHHHHHHHHHHHT----TSS-------CHHHHHHHCCCCCTCTTSSCHHHHHHHH T ss_pred ccccccHhHhcCCchHHHHHHHHHHHHHHHHHHHHHHc----CCC-------cHHHHHHHHHHHHHcCCCCCHHHHHHHH Confidence 23677777654 443 335555555666666665543 444 358899999 999999999999999999 Q sp|Q9BYF1|ACE2 574 VGAKNMNVRPLLNYFE 589 (805) Q Consensus 574 vgaknmnvrpllnyfe 589 (805) .|.. .+..+++.|+. T Consensus 667 ~G~~-~s~~~~l~~~~ 681 (683) T 5L44_A 667 RGRT-PRIEPLLDRRG 681 (683) T ss_dssp HSSS-CCSHHHHHHHT T ss_pred hCCC-CChHHHHHHcC Confidence 9986 88888888764 No 31 >5L43_B K-26 dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase, metalloprotease, K-26 tripeptide; HET: SO4; 1.8A {Astrosporangium hypotensionis K-26} Probab=99.77 E-value=4.9e-23 Score=205.45 Aligned_cols=512 Identities=16% Similarity=0.122 Sum_probs=318.9 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 28 FLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYP---------LQEIQNLTVKLQLQ 98 (805) Q Consensus 28 fldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmyp---------lqeiqnltvklqlq 98 (805) ++..+..-...+..-.+++++.+.++.+++..+..+.+..+.+.+..+.......|. +.+-+...++..++ T Consensus 76 ~i~~le~~~~~l~~~~~~~~~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~l~~~l~~~~~~~l~~e~~~~l~~~l~ 155 (683) T 5L43_B 76 TVAALERSGQVLTRVSAVFFNQSSSDTNPTVQEIQKQIIPKLTQHGDAIHLNRPLFARIKQISPDGLDAEQAWLLERYVT 155 (683) T ss_dssp CCCHHHHCCHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHHHHHHHHHHTCHHHHHHHHTCCSTTCCHHHHHHHHHHHH T ss_pred HHHHHHHhhHHHHHHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHhcCHHHHHHHHHHcccCCCHHHHHHHHHHHH Confidence 344444444555556778888888887888888888888888888766655444443 22223445556677 Q sp|Q9BYF1|ACE2 99 ALQQNGSSVLSED--KSKRLNTILNTMSTIYS----TGK----VCN---------PDN--------------PQ-ECLLL 144 (805) Q Consensus 99 alqqngssvlsed--kskrlntilntmstiys----tgk----vcn---------pdn--------------pq-eclll 144 (805) .+.++|...++++ +-..++..+..++..|+ +.+ +|- |.. +. .++-+ T Consensus 156 ~~~~~G~~l~~~~~e~~~~l~~~~~~l~~~f~~n~~~~~~~~~~~~~~~~~l~glp~~~~~~~~~~~~~~~~~G~~~i~l 235 (683) T 5L43_B 156 DFVRAGAELGAGDQERLKALNEELSTLSTRFEQNLLAHTNASAVIVDDVAQLDGLSDDSVKAAAETAKSRGLPGKYVIPL 235 (683) T ss_dssp HHHHTTTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCEEESCGGGGTTSCHHHHHHHHHHHHHTTCTTSEEECC T ss_pred HHHHhcccCCHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccceecCCHHHHCCCCHHHHHHHHHHHHHcCCCCCeEEec Confidence 7888888877765 34445666777778887 332 332 110 11 23444 Q sp|Q9BYF1|ACE2 145 E-PGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLI 223 (805) Q Consensus 145 e-pglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqli 223 (805) . |....+|.++-|...|-.+|++|.....+...+++++.+-+++++|+...|++|.+||-.++.+... T Consensus 236 ~~~~~~~il~~~~d~~~Rk~~~~a~~~~~~~~n~~~l~~lv~~R~~~A~~lGy~s~a~~~l~~~~~~~~----------- 304 (683) T 5L43_B 236 VLPTGQPGLAELTDRALRERIHRASIQRGVPDNEELIVRIATLRAERAKLLGYPTHAAYVVADQTAPTT----------- 304 (683) T ss_dssp CSSSSCGGGGTCCCHHHHHHHHHHHHTTTTTTTHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSSSCCH----------- T ss_pred CCCchHHHHHhCCCHHHHHHHHHHHHhcCCcchHHHHHHHHHHHHHHHHHhCCCCHHHHHcCCCCCCCH----------- Confidence 4 6788899999999999999999997655678899999999999999999999999999877665421 Q sp|Q9BYF1|ACE2 224 EDVEHTFEE-IKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAW 302 (805) Q Consensus 224 edvehtfee-ikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqaw 302 (805) ++|.....+ +++++..+|++++.+... + |+ --..|.-.|-....... .+.+..+.+..-. T Consensus 305 ~~v~~~L~~l~~~~~p~~~~~~~~l~~~-~---------------~~-~l~~wD~~y~~~~~~~~--~~~~~~~~~~~yf 365 (683) T 5L43_B 305 EAVTEMLGKLTPPAVANAHREADELREQ-A---------------GH-DLEPWDWSFYAEKVLKE--RYAIDGRQMRPYF 365 (683) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHH-H---------------TS-CCCGGGHHHHHHHHHHH--HHCCCHHHHGGGC T ss_pred HHHHHHHHHhhHHhHHHHHHHHHHHHHH-c---------------CC-CCCccCHHHHHHHHHHH--hhCCChhHhHhhc Confidence 223222222 346666778887754321 1 11 01223332322211111 1111111111111 Q sp|Q9BYF1|ACE2 303 DAQ-----RIFKEAEKFF--------------------VSVGL-PNMTQGFWENSMLTDPGNVQKAVCHPTAWD--LGKG 354 (805) Q Consensus 303 daq-----rifkeaekff--------------------vsvgl-pnmtqgfwensmltdpgnvqkavchptawd--lgkg 354 (805) ... .+|.-++++| .-.+- ......+|-. ....+|....+.|++..-. .... T Consensus 366 ~~~~v~~~~l~~~~~~lfg~~~~~~~~~~~w~~~v~~~~v~~~~~~~lg~~~lD-~~~r~~K~~~~~~~~~~~~~~~~~~ 444 (683) T 5L43_B 366 ELDRVLRDGVFHAATLLYGITFTERPDLVGYHPDVRVFEVFNEDGSQLGLFLGD-YYARPSKRGGAWMNSLVKQSTLEGT 444 (683) T ss_dssp BHHHHCCCCCHHHHHHHHCCEEEECTTSCCSSTTCEEEEEECTTSCEEEEEEEE-EECCTTSCSSCEEEEEECCBTTTTB T ss_pred CHHHHHHHHHHHHHHHHhCCEEEECCCCCCccCCeEEEEEEcCCCCEEEEEEEe-ccCCCCCCCCccccccccccccCCC Confidence 111 1222222221 00000 0111113322 1223344444566653210 0134 Q sp|Q9BYF1|ACE2 355 DFRILMCTK-----------VTMDDFLTAHHEMGHIQYDMAYA-AQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIG 422 (805) Q Consensus 355 dfrilmctk-----------vtmddfltahhemghiqydmaya-aqpfllrnganegfheavgeimslsaatpkhlksig 422 (805) ...|.+|.. .+.+|+.|.+||+||..+.+... .+|.+.+.+....|.|+.+.+|.+-+..|.+|++++ T Consensus 445 ~p~v~l~~~~~~~~~~~~~l~~~~~v~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~~~E~~~~~~~~L~~~~ 524 (683) T 5L43_B 445 RPVVVNNLNIAKPPAGEPTLMTFEEVNTMFHEFGHALHGLFSEVHYPRFSGTAVPRDFVEYPSQVNEMWAVWPSVLANYA 524 (683) T ss_dssp CCEEEEEEEECCCCTTCCCBCCHHHHHHHHHHHHHHHHHHTCCCSSGGGCTTCSCHHHHHHHHHHHTHHHHCHHHHHHHC T ss_pred CCEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHcCCCCccccCCCCCchhhccchHHhHhhhcCHHHHHHHh Confidence 577888887 89999999999999999988765 577777777889999999999999999999999987 Q sp|Q9BYF1|ACE2 423 LLSPDFQEDNETEINFLLK-----QALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY 497 (805) Q Consensus 423 llspdfqedneteinfllk-----qaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety 497 (805) ....+-+.-.+..++.++. +++.++..+++. .++.+ ++.+..+.+.+..-||+...+. |+.-|... . . T Consensus 525 ~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~~l~~a-~~D~~---lh~~~~~~~~~~~~~~~~~~~~-g~~~~~~~-~-~ 597 (683) T 5L43_B 525 RHWQTGDPMPKDLLDRMLKSQKYNQGYKTVEYLAAT-LLDWS---WHTFQTPPENALTFEHEALTTA-GVDLKLVP-P-R 597 (683) T ss_dssp BCTTTCCBCCHHHHHHHHHTTSTTHHHHHHHHHHHH-HHHHH---HTTCSSCCSCHHHHHHHHHHHT-TCCBTTBC-C-S T ss_pred hccCCCCCCCHHHHHHHHHhhchhHHHHHHHHHHHH-HHHHH---HhcCCCCCccHHHHHHHHHHHh-CCCCCCCC-C-c Confidence 6643222224455666654 567777777775 66655 3444444466777788866665 76544321 1 2 Q sp|Q9BYF1|ACE2 498 CDPASLFHVSN-DYS--FIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWTLALENV 573 (805) Q Consensus 498 cdpaslfhvsn-dys--firyytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgksepwtlalenv 573 (805) ..+.+..|+.. +|. +..|....+..++.-+++|++ ||+ +.++|+++. .+|+.|.+.||.-.++.. T Consensus 598 ~~~~~~~hi~~~~y~~~yy~Yl~s~v~a~~i~~~f~~~----~~~-------~~~~g~~~r~~iL~~G~s~~~~e~l~~f 666 (683) T 5L43_B 598 YRSTYFAHIWSSGYSAGYYSYIWSEVLDADTVDWFHEN----GGL-------LRENGDTFRQKLLSKGGSVDPMTAFQSF 666 (683) T ss_dssp SCGGGCHHHHTSSCTTCTTHHHHHHHHHHHHHHHHHHT----TSS-------CHHHHHHHCCCCCTCTTSSCHHHHHHHH T ss_pred ccccccHhHhcCCchHHHHHHHHHHHHHHHHHHHHHHc----CCC-------cHHHHHHHHHHHHHcCCCCCHHHHHHHH Confidence 23677777654 443 335555555666666665543 444 358899999 999999999999999999 Q sp|Q9BYF1|ACE2 574 VGAKNMNVRPLLNYFE 589 (805) Q Consensus 574 vgaknmnvrpllnyfe 589 (805) .|.. .+..+++.|+. T Consensus 667 ~G~~-~s~~~~l~~~~ 681 (683) T 5L43_B 667 RGRT-PRIEPLLDRRG 681 (683) T ss_dssp HSSS-CCSHHHHHHHT T ss_pred hCCC-CChHHHHHHcC Confidence 9986 88888888764 No 32 >1Y79_1 Peptidyl-Dipeptidase Dcp (E.C.3.4.15.5); hinge bending peptidyl dipeptidase; HET: TRP; 2.0A {Escherichia coli} Probab=99.44 E-value=4.5e-17 Score=163.19 Aligned_cols=501 Identities=14% Similarity=0.139 Sum_probs=281.7 Template_Neff=9.600 Q sp|Q9BYF1|ACE2 41 YQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMY-------------PLQEIQNLTVKLQLQALQQNGSSV 107 (805) Q Consensus 41 yqsslaswnyntniteenvqnmnnagdkwsaflkeqstlaqmy-------------plqeiqnltvklqlqalqqngssv 107 (805) .-.+.+++-+.++.+++.-..-..+..+.+++..+..+=..+| .+.+-+...++..++....+|... T Consensus 70 ~~~~~~~~l~~~~~~~e~r~a~~~~~~~~~~~~~~~~~~~~ly~~l~~~~~~~~~~~l~~e~~r~l~~~l~~~~~~G~~L 149 (680) T 1Y79_1 70 RVTSVFFAMTAAHTNDELQRLDEQFSAELAELANDIYLNGELFARVDAVWQRRESLGLDSESIRLVEVIHQRFVLAGAKL 149 (680) T ss_pred HHHHHHHHHHhcCCCHHHHHHHHHHHHHHHHHHHHHccCHHHHHHHHHHHcCCCccCCCHHHHHHHHHHHHHHHHcCCCC Confidence 3455666667777555554445555555665544432111111 122223334555666677788765 Q sp|Q9BYF1|ACE2 108 LSEDKSKRLNTILNT---MSTIYSTGKVC---------N--------PD----------------NPQECLLLEPGLNEI 151 (805) Q Consensus 108 lsedkskrlntilnt---mstiystgkvc---------n--------pd----------------npqeclllepglnei 151 (805) .++ +.+|+..+... +++.|+..-.. . |+ .+...-+-.|.+..+ T Consensus 150 ~~~-~~~~l~~l~~~i~~l~~~f~~n~~~~~~~~~~~~~~~~~L~g~p~~~l~~~~~~a~~~~~~~~~~i~l~~~~~~~~ 228 (680) T 1Y79_1 150 AQA-DKAKLKVLNTEAATLTSQFNQRLLAANKSGGLVVNDIAQLAGMSEQEIALAAEAAREKGLDNKWLIPLLNTTQQPA 228 (680) T ss_pred CHH-HHHHHHHHHHHHHHHHHHHHHhcccccccccccCCCHHHHcCCCHHHHHHHHHHHHHcCCCCCeEeeCCCccHHHH Confidence 444 44666655443 22223211110 0 00 111122223567888 Q sp|Q9BYF1|ACE2 152 MANSLDYNERLWAWESWRSEVG----KQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVE 227 (805) Q Consensus 152 mansldynerlwaweswrsevg----kqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrgqliedve 227 (805) |+++-|...|--+|..|.+... ....+++.+.+.+++++|+...|++|.+|+-.+.. ..+..++.+-.. T Consensus 229 l~~~~d~~~R~~~~~a~~~~~~~~~~~~~~~~l~~lv~~R~~~A~llGy~s~~~~~l~~~m-------~~~~~~v~~~L~ 301 (680) T 1Y79_1 229 LAEMRDRATREKLFIAGWTRAEKNDANDTRAIIQRLVEIRAQQATLLGFPHYAAWKIADQM-------AKTPEAALNFMR 301 (680) T ss_pred HHhCCCHHHHHHHHHHHHhccccCCccccHHHHHHHHHHHHHHHHHhCCCCHHHHHhcccC-------CCCHHHHHHHHH Confidence 9999999999999999975543 46789999999999999999999999999864431 223334444455 Q sp|Q9BYF1|ACE2 228 HTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQR- 306 (805) Q Consensus 228 htfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqr- 306 (805) ...+.++|++++.++.+++.....+ |+--...|...|-...+-. ...+++++.+.+-....+ T Consensus 302 ~l~~~~~p~~~~e~~~l~~~~~~~~---------------g~~~l~~wD~~y~~~~~~~--~~~~~~~~~~~~yf~~~~v 364 (680) T 1Y79_1 302 EIVPAARQRASDELASIQAVIDKQQ---------------GGFSAQPWDWAFYAEQVRR--EKFDLDEAQLKPYFELNTV 364 (680) T ss_pred HHHHHhHHHHHHHHHHHHHHHHHhc---------------CCCCCCcccHHHHHHhHHh--hccCCCHHHHHhhCCHHHH Confidence 5567888999988888887554322 1111233433333222211 223343444433333332 Q sp|Q9BYF1|ACE2 307 ----IFKEAEKFFVSVGLPN---MTQGFWENSM----------------LTDP----GNVQKAVCHPTAWD--LGKGDFR 357 (805) Q Consensus 307 ----ifkeaekffvsvglpn---mtqgfwensm----------------ltdp----gnvqkavchptawd--lgkgdfr 357 (805) +|+.+++.| |+-- ....+|..+. .-|+ |.-..+-|.+..-. ....+.+ T Consensus 365 ~~~~l~~~~~~~f---g~~~~~~~~~~~W~~~v~~~~v~~~~~~~lg~~y~D~~~r~~K~~~~~~~~~~~~~~~~~~~p~ 441 (680) T 1Y79_1 365 LNEGVFWTANQLF---GIKFVERFDIPVYHPDVRVWEIFDHNGVGLALFYGDFFARDSKSGGAWMGNFVEQSTLNKTHPV 441 (680) T ss_pred HHHhHHHHHHHHh---CCEEEEcCCCccccCCceEEEEEcCCCCEEEEEEEeCCCCCCCCCCCcccceecccCCCCCCCE Confidence 444555544 2111 0111233322 1121 22222223221000 0012344 Q sp|Q9BYF1|ACE2 358 I-----------LMCTKVTMDDFLTAHHEMGHIQYDMAYAAQ-PFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLS 425 (805) Q Consensus 358 i-----------lmctkvtmddfltahhemghiqydmayaaq-pfllrnganegfheavgeimslsaatpkhlksiglls 425 (805) | -.|+.++.+|+.|.+||+||..+.+..... +.+...+..-.|.|+.+.+|..-+..|..|+.++.-- T Consensus 442 v~~~~n~~~~~~~~~~ll~~~~v~tl~HE~GHalh~~l~~~~~~~~~~~~~~~d~~E~~S~~~E~~~~~~~~l~~~~~~~ 521 (680) T 1Y79_1 442 IYNVCNYQKPAAGEPALLLWDDVITLFHEFGHTLHGLFARQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHY 521 (680) T ss_pred EEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHhCCCCchhcCCCCcccccccchHhhHHHhcCHHHHHHHhhcC Confidence 4 267778899999999999999998776543 2222344678899999999999999999999876432 Q sp|Q9BYF1|ACE2 426 PDFQEDNETEINFLLK-----QALTIVGTLPFTYMLEKWRWMVFKGE--IPKDQWMKKWWEMKREIVGVVEPVPHDETYC 498 (805) Q Consensus 426 pdfqedneteinfllk-----qaltivgtlpftymlekwrwmvfkge--ipkdqwmkkwwemkreivgvvepvphdetyc 498 (805) .+-+.-.+..++.|++ +++.++..+.+ ..++.+-+-...++ +..+++ .||+...+-.|+ .+.+ ..+. T Consensus 522 ~~~~~l~~~~~~~l~~~~~~~~~~~~~~~l~~-~~~D~~lh~~~~~~~~~~~~~~--~~~~~~~~~~~~-~~~~--~~~~ 595 (680) T 1Y79_1 522 QSGAAMPDELQQKMRNASLFNKGYEMSELLSA-ALLDMRWHCLEENEAMQDVDDF--ELRALVAENMDL-PAIP--PRYR 595 (680) T ss_pred CCCCCCCHHHHHHHHHHhhHHHHHHHHHHHHH-HHHHHHHhcCCCCCCCCChhHH--HHHHHHHHHHCC-CCCC--CCcc Confidence 1111112334555543 35555555544 46666555444332 333444 455544434465 2222 2333 Q sp|Q9BYF1|ACE2 499 DPASLFHVSN-DYS--FIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGKSEPWTLALENVV 574 (805) Q Consensus 499 dpaslfhvsn-dys--firyytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgksepwtlalenvv 574 (805) +.+..|+.. +|. +..|....++.+++.+.+|+ +|++ +.++|+++. .+|..|.+.++.-.++... T Consensus 596 -~~~~~hi~~~~y~~~yysY~~s~v~a~~i~~~~~~----~~~~-------~~~~g~~~r~~~L~~G~s~~~~e~~~~fl 663 (680) T 1Y79_1 596 -SSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVE----QGGL-------TRENGLRFREAILSRGNSEDLERLYRQWR 663 (680) T ss_pred -ccccHHHHcCCcchHHHHHHHHHHHHHHHHHHHHH----hCCC-------CHHHHHHHHHHhhccCCCCCHHHHHHHHh Confidence 677777753 333 23444455555565555544 3443 257899998 8999999999999999998 Q sp|Q9BYF1|ACE2 575 GAKNMNVRPLLNYF 588 (805) Q Consensus 575 gaknmnvrpllnyf 588 (805) |.. .+..+++.++ T Consensus 664 G~~-~~~~~~l~~~ 676 (680) T 1Y79_1 664 GKA-PKIMPMLQHR 676 (680) T ss_pred CCC-CCHHHHHHHc Confidence 876 7777777765 No 33 >4KA7_A Oligopeptidase A, short endogenous peptide; Protease, Mitochondria, chloroplast, HYDROLASE-HYDROLASE SUBSTRATE; HET: GOL; 1.8A {Arabidopsis thaliana} Probab=99.43 E-value=5.8e-17 Score=163.74 Aligned_cols=407 Identities=15% Similarity=0.103 Sum_probs=238.2 Template_Neff=9.500 Q sp|Q9BYF1|ACE2 144 LEPGLNEIMANSLDYNERLWAWESWRSEVG---KQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220 (805) Q Consensus 144 lepglneimansldynerlwaweswrsevg---kqlrplyeeyvvlknemaranhyedygdywrgdyevngvdgydysrg 220 (805) -.|.+..+|.++-|...|--+|++|.+..+ ....+++.+.+.+++++|+...|++|.+|+-.+..+ +.. T Consensus 239 ~~~~~~~il~~~~d~~~Rk~~~~a~~~~~~~~~~~~~~~l~~l~~~R~~~A~llGy~s~a~~~l~~~~~--------~~~ 310 (714) T 4KA7_A 239 DAPSYLPVMQHAKNRALREEVYRAYLSRASSGDLDNTAIIDQILKLRLEKAKLLGYNNYAEVSMAMKMA--------TVE 310 (714) T ss_dssp SHHHHHHHHHHCCCHHHHHHHHHHHHTTTCSGGGCCHHHHHHHHHHHHHHHHHTTCSSHHHHHHTTSSC--------CHH T ss_pred CCccHHHHHHhCCCHHHHHHHHHHHHcccCCCCcChHHHHHHHHHHHHHHHHHhCCCCHHHHHHHHhcC--------CHH Confidence 346678899999899999999999987654 568899999999999999999999999998654333 222 Q sp|Q9BYF1|ACE2 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQK-PNIDVTDAMVD 299 (805) Q Consensus 221 qliedvehtfeeikplyehlhayvraklmnaypsyispigclpahllgdmwgrfwtnlysltvpfgqk-pnidvtdamvd 299 (805) .+.+-++...+.++|+++..++.++......+. . |.---..|...|-.. ++-+. .+++ ...+. T Consensus 311 ~v~~~L~~l~~~~~~~~~~~~~~l~~~~~~~~~--------~-----~~~~l~~wD~~y~~~-~~~~~~~~~~--~~~~~ 374 (714) T 4KA7_A 311 KAAELLEKLRSASWDAAVQDMEDLKSFAKNQGA--------A-----ESDSMTHWDTTFWSE-RLRESKYDIN--EEELR 374 (714) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTC--------G-----GGGSCCTTTHHHHHH-HHHHHHHCCC--HHHHG T ss_pred HHHHHHHHHHHhcHHHHHHHHHHHHHHHHHcCC--------C-----CCCCCCcccHHHHHH-HHHHhcCCCC--HHHHH Confidence 333444445556677777666666643222111 0 000012333332222 11111 1111 11111 Q sp|Q9BYF1|ACE2 300 QAWD----AQRIFKEAEKFFVSVGLPNMT--QGFWENSM----------------LTDP----G-NVQKAVCHPTAWD-- 350 (805) Q Consensus 300 qawd----aqrifkeaekffvsvglpnmt--qgfwensm----------------ltdp----g-nvqkavchptawd-- 350 (805) .-.. ...+|+-++++|- +++.... ...|..+. .-|+ | ....+.|++..-. T Consensus 375 ~yf~~~~~~~~i~~~~~~~f~-l~~~~~~~~~~~w~~~v~~~~v~~~~~~~~g~~~lD~~~r~~kk~~g~~~~~~~~~~~ 453 (714) T 4KA7_A 375 PYFSLPKVMDGLFSLAKTLFG-IDIEPADGLAPVWNNDVRFYRVKDSSGNPIAYFYFDPYSRPSEKRGGAWMDEVVSRSR 453 (714) T ss_dssp GGCBHHHHHHHHHHHHHHHHC-CEEEECTTSSCCSSTTCEEEEEECTTSCEEEEEEEEEECCTTTSCSSCEEEEEECCBS T ss_pred hcCCHHHHHHHHHHHHHHHHC-cEEEECCCCCCcccCCcEEEEEEcCCCCeEEEEEECCCCCCCCCCCCcccccccccch Confidence 1111 2345555566655 4444332 12343322 1222 2 1222334322110 Q sp|Q9BYF1|ACE2 351 -LG-----KGDFRILMC-----------TKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLR--NGANEGFHEAVGEIMSLS 411 (805) Q Consensus 351 -lg-----kgdfrilmc-----------tkvtmddfltahhemghiqydmayaaqpfllr--nganegfheavgeimsls 411 (805) ++ .....|+|+ +.++.+|+.|.+||+||..+.+....+...+. .+..-.|.|+.+.+|..- T Consensus 454 ~~~~~~~~~~~p~v~~~~n~~~~~~~~~~ll~~~~v~tl~HE~GHalh~~l~~~~~~~~~g~~~~~~d~~E~~S~~~E~~ 533 (714) T 4KA7_A 454 VMAQKGSSVRLPVAHMVCNQTPPVGDKPSLMTFREVETVFHQFGHALQHMLTKQDEGLVAGIRNIEWDAVELPSQFMENW 533 (714) T ss_dssp TTCCTTSSCBCCEEEEEEEECCCCTTSCCBCCHHHHHHHHHHHHHHHHHHSCCCCCGGGSTTTTCCGGGTTHHHHHHHGG T ss_pred hHhcCCCceeccEEEEEecCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHhhCCCchhhcCccccccccchhcHHHHHHH Confidence 00 123456654 44569999999999999999887765554444 256889999999999999 Q sp|Q9BYF1|ACE2 412 AATPKHLKSIGLLSPDFQEDNETEINFLLKQ-----ALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVG 486 (805) Q Consensus 412 aatpkhlksigllspdfqedneteinfllkq-----altivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivg 486 (805) +..|..|+.++.-..+-++..+..++.+++. ++.++. .++-..++.+.+-...+.-| ..+-+-|+++..+. | T Consensus 534 ~~~~~~L~~~~~~~~~~~~~~~~~~~~l~~~~~~~~~~~~~~-~~~~~~~D~~lh~~~~~~~~-~~~~~~~~~~~~~~-~ 610 (714) T 4KA7_A 534 CYHRDTLMSIAKHYETGETLPEEVYKKLLAARTFRAGSFSLR-QLKFASVDLELHTKYVPGGP-ESIYDVDQRVSVKT-Q 610 (714) T ss_dssp GGSHHHHHHHCBCTTTCCBCCHHHHHHHHHTTTTTHHHHHHH-HHHHHHHHHHHTTTCCTTSS-CCHHHHHHHHHHHH-C T ss_pred hcCHHHHHHHhhccCCCCCCCHHHHHHHHHHhhhchHHHHHH-HHHHHHHHHHHHhcCCCCCC-CCHHHHHHHHHHHh-C Confidence 9999999887653322222233446666654 555544 55667788877776643323 23335577664444 3 Q sp|Q9BYF1|ACE2 487 VVEPVPHDETYCDPASLFHVSN-DY--SFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLF-NMLRLGK 562 (805) Q Consensus 487 vvepvphdetycdpaslfhvsn-dy--sfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklf-nmlrlgk 562 (805) -+.+.+ ..-.+.+..|+-. +| .+..|-...++.+++-+.+|+ +|+. +...+.++|+++. ++|..|. T Consensus 611 ~~~~~~---~~~~~~~~~hi~~~~y~a~yY~Y~~a~v~a~~i~~~f~~----~~~~---~~~~~~~~g~~~~~~~L~~G~ 680 (714) T 4KA7_A 611 VIPPLP---EDRFLCSFSHIFAGGYAAGYYSYKWAEVLSADAFSAFED----AGLD---DIKAVKETGQRFRNTILALGG 680 (714) T ss_dssp SSCCCT---TCCGGGGCHHHHSSTTTTTTTHHHHHHHHHHHHHHHHHH----HCTT---CHHHHHHHHHHHHTTTTTCTT T ss_pred CCCCCC---CCcccccchhhhccCcchHHHHHHHHHHHHHHHHHHHHH----cCCC---chHHHHHHHHHHHHHHhhcCC Confidence 232211 1124456666643 44 444554455555555554444 2321 2234678999999 9999999 Q sp|Q9BYF1|ACE2 563 SEPWTLALENVVGAKNMNVRPLLNYFE 589 (805) Q Consensus 563 sepwtlalenvvgaknmnvrpllnyfe 589 (805) +.++.-.++...|.. .+..+++.++. T Consensus 681 s~~~~e~~~~~~g~~-~~~~~~l~~~~ 706 (714) T 4KA7_A 681 GKAPLKVFVEFRGRE-PSPEPLLRHNG 706 (714) T ss_dssp SSCHHHHHHHHHSSC-CCSHHHHHHTT T ss_pred CCCHHHHHHHHhCCC-CChHHHHHHcC Confidence 999999998877764 66777777653 No 34 >2KNC_B Integrin alpha-IIb, Integrin beta-3; integrin, transmembrane signaling, protein structure; NMR {Homo sapiens} Probab=92.66 E-value=0.036 Score=45.32 Aligned_cols=31 Identities=13% Similarity=0.358 Sum_probs=11.0 Template_Neff=7.700 Q sp|Q9BYF1|ACE2 733 PPNQPPVSIWLIVFGVVMGVIVVGIVILIFT 763 (805) Q Consensus 733 ppnqppvsiwlivfgvvmgvivvgivilift 763 (805) .+...+.+.+.|+.|++.|++++|++++++. T Consensus 2 ~~~~~~~~~~~i~g~vvggiv~l~ll~~~i~ 32 (79) T 2KNC_B 2 AMGSKGPDILVVLLSVMGAILLIGLAALLIW 32 (79) T ss_dssp CSSCS-------------SHHHHHHHHHHHH T ss_pred CCCCCcCchHHHHHHHHHHHHHHHHHHHHHH Confidence 3455677788888888888887777654433 No 35 >2L8S_A Integrin alpha-1; Integrin Alpha1, Transmembrane Region, Detergent; NMR {Homo sapiens} Probab=87.55 E-value=0.29 Score=40.19 Aligned_cols=43 Identities=26% Similarity=0.506 Sum_probs=30.9 Template_Neff=5.400 Q sp|Q9BYF1|ACE2 736 QPPVSIWLIVFGVVMGVIVVGIVILIF--TGIRDRKKKNKARSGE 778 (805) Q Consensus 736 qppvsiwlivfgvvmgvivvgivilif--tgirdrkkknkarsge 778 (805) .+++.+|.|+.+++.|++++++++++. .|.-.||++.+....| T Consensus 4 ~~~~p~wiii~svl~GlllL~iii~iL~K~GFFkRk~~~~~~~~~ 48 (54) T 2L8S_A 4 PGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEKLE 48 (54) T ss_dssp CCCCCTHHHHHHHHHHHHHHHHHHHHHHHHHHTTSCCSCCCCC-- T ss_pred CCCccHHHHHHHHHHHHHHHHHHHHHHHHcCCCCCCcchHHHHhc Confidence 467889999999999998877765554 5777777766655444 No 36 >2N2A_B Receptor tyrosine-protein kinase erbB-2; HER2, ErbB2, Tyrosine kinase, Activation; NMR {Homo sapiens} Probab=86.49 E-value=0.38 Score=38.36 Aligned_cols=30 Identities=27% Similarity=0.208 Sum_probs=13.8 Template_Neff=7.000 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 742 wlivfgvvmgvivvgiviliftgirdrkkk 771 (805) ..|+.||+.|++++.++++++.-++.|+++ T Consensus 9 ~~I~~~Vvg~l~~~~~i~~~~~~~~Rrr~~ 38 (58) T 2N2A_B 9 TSIISAVVGILLVVVLGVVFGILIKRRQQK 38 (58) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHTTC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhHHHH Confidence 345556655555444444333333434333 No 37 >2KNC_A Integrin alpha-IIb, Integrin beta-3; integrin, transmembrane signaling, protein structure; NMR {Homo sapiens} Probab=85.75 E-value=0.45 Score=38.68 Aligned_cols=40 Identities=23% Similarity=0.570 Sum_probs=29.1 Template_Neff=5.900 Q sp|Q9BYF1|ACE2 735 NQPPVSIWLIVFGVVMGVIVVGIVILI--FTGIRDRKKKNKA 774 (805) Q Consensus 735 nqppvsiwlivfgvvmgvivvgivili--ftgirdrkkknka 774 (805) ..+++++|.|+.+++.|++++++++++ -.|...||++... T Consensus 6 ~~~~~~~wiiv~svl~GlllL~li~~iL~K~GFFkRk~~~~~ 47 (54) T 2KNC_A 6 EERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLE 47 (54) T ss_dssp TTTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTCCSCC T ss_pred ccccccHHHHHHHHHHHHHHHHHHHHHHHHcCccccCCCccc Confidence 345788999999999999887766544 4577777665543 No 38 >2M3E_A Integrin alpha-L; integrin alpah L TM domain; NMR {Homo sapiens} Probab=85.42 E-value=0.48 Score=38.20 Aligned_cols=39 Identities=18% Similarity=0.400 Sum_probs=29.1 Template_Neff=5.700 Q sp|Q9BYF1|ACE2 736 QPPVSIWLIVFGVVMGVIVVGIVILIF--TGIRDRKKKNKA 774 (805) Q Consensus 736 qppvsiwlivfgvvmgvivvgivilif--tgirdrkkknka 774 (805) ..++.+|.|+.+++.|++++.+++++. .|...||++.+. T Consensus 7 ~~~~~~wiii~svi~GlllL~ii~~iL~K~GFFkRk~~~~~ 47 (50) T 2M3E_A 7 YEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKM 47 (50) T ss_dssp TTCCCHHHHHHHHHHHHHHHHHHHHHHHHHTSGGGSCCCCC T ss_pred chhhcHHHHHHHHHHHHHHHHHHHHHHHHcCcchhhhhHHH Confidence 457889999999999998877765554 566677666543 No 39 >6J8H_C Sodium channel subunit beta-2, Sodium; voltage-gated sodium channel, MEMBRANE PROTEIN; HET: 9SL, NAG;{Homo sapiens} Probab=84.27 E-value=0.6 Score=37.23 Aligned_cols=8 Identities=13% Similarity=0.576 Sum_probs=3.9 Template_Neff=12.500 Q sp|Q9BYF1|ACE2 591 LFTWLKDQ 598 (805) Q Consensus 591 lftwlkdq 598 (805) -++|.++. T Consensus 64 ~v~W~~~~ 71 (215) T 6J8H_C 64 SLNWTYQE 71 (215) T ss_pred EEEEEEec Confidence 34555543 No 40 >2N9Y_B Integrin alpha-IIb, Integrin beta-3; transmembrane complex, integrin receptor, cell; NMR {Homo sapiens} Probab=83.96 E-value=0.63 Score=34.96 Aligned_cols=30 Identities=13% Similarity=0.345 Sum_probs=21.3 Template_Neff=7.200 Q sp|Q9BYF1|ACE2 737 PPVSIWLIVFGVVMGVIVVGIVILIFTGIR 766 (805) Q Consensus 737 ppvsiwlivfgvvmgvivvgiviliftgir 766 (805) ++.+++.|+.|++-|++++|+++++..-.+ T Consensus 5 ~~~~~~~I~ggvvggi~ligli~lli~~~~ 34 (43) T 2N9Y_B 5 KCPDILVVLLSVMGAILLIGLAPLLIWKLL 34 (43) T ss_dssp SSCCHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CCCcHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345667788899999888887766554443 No 41 >6JXR_n T-cell surface glycoprotein CD3 zeta; IMMUNE SYSTEM;{Homo sapiens} Probab=83.38 E-value=0.7 Score=37.95 Aligned_cols=7 Identities=14% Similarity=0.700 Sum_probs=3.7 Template_Neff=12.900 Q sp|Q9BYF1|ACE2 591 LFTWLKD 597 (805) Q Consensus 591 lftwlkd 597 (805) -+.|.++ T Consensus 154 ~~~W~~~ 160 (291) T 6JXR_n 154 ELSWWVN 160 (291) T ss_pred eEEEEEC Confidence 4556553 No 42 >2K9J_A Integrin alpha-IIb light chain, Integrin; integrin, transmembrane complex, Cell adhesion; NMR {Homo sapiens} Probab=83.01 E-value=0.74 Score=35.92 Aligned_cols=39 Identities=26% Similarity=0.696 Sum_probs=28.8 Template_Neff=5.800 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIF--TGIRDRKK 770 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgivilif--tgirdrkk 770 (805) ||+..+++.+|.|+.+++.|++++.+++++. .|.-.||+ T Consensus 1 ~~~~~~~~~~wiii~svl~GlllL~li~~iL~K~GFFkRk~ 41 (42) T 2K9J_A 1 GALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNR 41 (42) T ss_dssp CCSSCSCCHHHHHHHHHHHHHHHHHHHHHHHHTTTSSCCCC T ss_pred CchhhccccHHHHHHHHHHHHHHHHHHHHHHHHhCccccCC Confidence 5667788999999999999998887765554 34444443 No 43 >2N5S_A Epidermal growth factor receptor (E.C.2.7.10.1); transmembrane, TRANSFERASE; NMR {Homo sapiens} Probab=82.67 E-value=0.79 Score=34.05 Aligned_cols=10 Identities=30% Similarity=0.504 Sum_probs=4.2 Template_Neff=8.700 Q sp|Q9BYF1|ACE2 744 IVFGVVMGVI 753 (805) Q Consensus 744 ivfgvvmgvi 753 (805) |+.|++.|++ T Consensus 8 i~~gvv~~~~ 17 (54) T 2N5S_A 8 IATGMVGALL 17 (54) T ss_dssp TTHHHHHHHH T ss_pred HHHHHHHHHH Confidence 3444444433 No 44 >4UM8_D INTEGRIN ALPHA-V, INTEGRIN BETA-6; IMMUNE SYSTEM, CELL SURFACE RECEPTOR; HET: CAC, SO4, NAG, CA, MAN, BMA; 2.852A {HOMO SAPIENS} Probab=80.82 E-value=1 Score=48.98 Aligned_cols=25 Identities=32% Similarity=0.786 Sum_probs=0.0 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIF 762 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivilif 762 (805) +..+|.|++|++.|++++|+++|+. T Consensus 705 ~~~~~~i~~gvv~~ivli~l~~l~i 729 (788) T 4UM8_D 705 PPNIPMIMLGVSLAILLIGVVLLCI 729 (788) T ss_dssp ------------------------- T ss_pred CCCHHHHHHHHHHHHHHHHHHHHHH Confidence 5667788889888888888776654 No 45 >4UM8_B INTEGRIN ALPHA-V, INTEGRIN BETA-6; IMMUNE SYSTEM, CELL SURFACE RECEPTOR; HET: MAN, NAG, CA, SO4, CAC, BMA; 2.852A {HOMO SAPIENS} Probab=78.69 E-value=1.4 Score=48.08 Aligned_cols=25 Identities=32% Similarity=0.786 Sum_probs=19.0 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIF 762 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivilif 762 (805) +..+|.|++|++.|++++|+++|+. T Consensus 705 ~~~~~~i~~gvv~~ivll~l~~lli 729 (788) T 4UM8_B 705 PPNIPMIMLGVSLAILLIGVVLLCI 729 (788) T ss_pred CchHHHHHHHHHHHHHHHHHHHHHH Confidence 5677888888888888887766543 No 46 >1AFO_A GLYCOPHORIN A; INTEGRAL MEMBRANE PROTEIN, HUMAN GLYCOPHORIN; NMR {Homo sapiens} SCOP: j.35.1.1 Probab=75.93 E-value=1.9 Score=35.46 Aligned_cols=37 Identities=46% Similarity=0.680 Sum_probs=25.9 Template_Neff=2.500 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkk 771 (805) .++-+.|+ |.+|+|||+.|+ +|++++|-..||.-+|| T Consensus 4 ~h~fs~p~-i~lII~~VmaGI--IG~Il~i~y~I~rl~kk 40 (40) T 1AFO_A 4 AHHFSEPE-ITLIIFGVMAGV--IGTILLISYGIRRLIKK 40 (40) T ss_dssp SCCSSCCH-HHHHHHHHHHHH--HHHHHHHHHHHHHHSCC T ss_pred ccCCChHH-HHHHHHHHHHHH--HHHHHHHHHHHHHHhcC Confidence 34445555 789999999987 46777777777765554 No 47 >6A69_B Plasma membrane calcium-transporting ATPase 1; Membrane protein, STRUCTURAL PROTEIN; HET: NAG; 4.11A {Homo sapiens} Probab=75.89 E-value=1.9 Score=35.66 Aligned_cols=15 Identities=13% Similarity=0.375 Sum_probs=6.6 Template_Neff=12.700 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGVIVVG 756 (805) Q Consensus 742 wlivfgvvmgvivvg 756 (805) +.+++|++++++++. T Consensus 224 ~~~~~~~~~~~~~~~ 238 (282) T 6A69_B 224 LWPFLGILAEIIILV 238 (282) T ss_pred HHHHHHHHHHHHHHH Confidence 334445444444433 No 48 >6AGF_B Sodium channel protein PaFPC1, Mu-diguetoxin-Dc1a; sodium channel, MEMBRANE PROTEIN; HET: 6OU, 9Z9, NAG, BMA; 3.2A {Homo sapiens} Probab=75.28 E-value=2 Score=35.68 Aligned_cols=22 Identities=18% Similarity=0.176 Sum_probs=0.4 Template_Neff=11.700 Q sp|Q9BYF1|ACE2 773 KARSGENPYASIDISKGENNPGF 795 (805) Q Consensus 773 karsgenpyasidiskgennpgf 795 (805) +.+..+.+|+.+... ..+|+.. T Consensus 192 ~~~~~~~~~~~~~~~-~~~~~~~ 213 (218) T 6AGF_B 192 AAQENASEYLAITSE-SKENCTG 213 (218) T ss_dssp C---------------------- T ss_pred HHHhhHhhhcccChh-hhhcccc Confidence 344446677766533 3344433 No 49 >6J8J_B Sodium channel subunit beta-2, Sodium; voltage-gated sodium channel, MEMBRANE PROTEIN; HET: 9SR, NAG;{Homo sapiens} Probab=75.28 E-value=2 Score=35.68 Aligned_cols=22 Identities=18% Similarity=0.176 Sum_probs=11.0 Template_Neff=11.700 Q sp|Q9BYF1|ACE2 773 KARSGENPYASIDISKGENNPGF 795 (805) Q Consensus 773 karsgenpyasidiskgennpgf 795 (805) +.+..+.+|+.+... ..+|+.. T Consensus 192 ~~~~~~~~~~~~~~~-~~~~~~~ 213 (218) T 6J8J_B 192 AAQENASEYLAITSE-SKENCTG 213 (218) T ss_pred HHHhhHhhhcccChh-hhhcccc Confidence 344446677766533 3344433 No 50 >6C14_A Protocadherin-15, LHFPL tetraspan subfamily member; PCDH15, LHFPL5, protocadherin, tip link;{Mus musculus} Probab=74.52 E-value=2.2 Score=40.59 Aligned_cols=23 Identities=4% Similarity=0.128 Sum_probs=12.6 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVIL 760 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivil 760 (805) +..+.+|+++++++++++.++++ T Consensus 238 ~~~~~li~laill~l~~lili~~ 260 (337) T 6C14_A 238 YTEGALLALAFIIILCCIPAILV 260 (337) T ss_dssp SHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHH Confidence 33556677776666654433333 No 51 >6UJB_B Integrin alpha-V, Integrin beta-8, C6D4; glycoprotein, adhesion, signaling, SIGNALING PROTEIN-IMMUNE; HET: MAN, NAG, BMA; 3.51A {Homo sapiens} Probab=73.28 E-value=2.5 Score=45.78 Aligned_cols=25 Identities=16% Similarity=0.359 Sum_probs=0.0 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIF 762 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivilif 762 (805) +..+|.|++|++.+++++++++|++ T Consensus 637 ~~~~~~i~~~v~~~illi~l~~l~i 661 (727) T 6UJB_B 637 SPSYLRIFFIIFIVTFLIGLLKVLI 661 (727) T ss_dssp ------------------------- T ss_pred CccHHHHHHHHHHHHHHHHHHHHHH Confidence 4567788888888887777665543 No 52 >6UJA_B Integrin alpha-V, Integrin beta-8, Transforming; glycoprotein, adhesion, signaling, SIGNALING PROTEIN; HET: MAN, BMA, NAG; 3.3A {Homo sapiens} Probab=73.28 E-value=2.5 Score=45.78 Aligned_cols=25 Identities=16% Similarity=0.359 Sum_probs=0.0 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIF 762 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgivilif 762 (805) +..+|.|++|++.+++++++++|++ T Consensus 637 ~~~~~~i~~~v~~~illi~l~~l~i 661 (727) T 6UJA_B 637 SPSYLRIFFIIFIVTFLIGLLKVLI 661 (727) T ss_dssp ------------------------- T ss_pred CccHHHHHHHHHHHHHHHHHHHHHH Confidence 4567788888888887777665543 No 53 >2M20_A Epidermal growth factor receptor (E.C.2.7.10.1); Transmembrane, Cell Signaling, Juxtamembrane, SIGNALING; NMR {Homo sapiens} Probab=72.68 E-value=2.6 Score=32.92 Aligned_cols=10 Identities=30% Similarity=0.511 Sum_probs=4.3 Template_Neff=7.900 Q sp|Q9BYF1|ACE2 744 IVFGVVMGVI 753 (805) Q Consensus 744 ivfgvvmgvi 753 (805) |+.|||.|++ T Consensus 5 i~~~vvg~~~ 14 (60) T 2M20_A 5 IATGLVGALL 14 (60) T ss_dssp HHHHHHHHHH T ss_pred HHHHHHHHHH Confidence 3444444433 No 54 >5OR7_C Capsid protein, CMRF35-like molecule 1; CR10, sCD300lf, complex, VIRAL PROTEIN; 2.046A {Murine norovirus GV/CR10/2005/USA} Probab=72.61 E-value=2.7 Score=38.46 Aligned_cols=6 Identities=17% Similarity=0.506 Sum_probs=2.6 Template_Neff=11.000 Q sp|Q9BYF1|ACE2 592 FTWLKD 597 (805) Q Consensus 592 ftwlkd 597 (805) +.|.++ T Consensus 52 v~W~~~ 57 (330) T 5OR7_C 52 KYWCQG 57 (330) T ss_pred EEEEEC Confidence 344443 No 55 >2MFR_A Insulin receptor (E.C.2.7.10.1); insulin recepotr, membrane protein, detergent; NMR {Homo sapiens} Probab=69.03 E-value=3.6 Score=33.93 Aligned_cols=38 Identities=21% Similarity=0.174 Sum_probs=19.5 Template_Neff=5.900 Q sp|Q9BYF1|ACE2 740 SIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGEN 779 (805) Q Consensus 740 siwlivfgvvmgvivvgiviliftgirdrkkknkarsgen 779 (805) +++++++|.+..++++.+++. ...-.+|||+..|+||. T Consensus 15 ~~~~iiI~pvi~iilii~~~~--~~~~~~kKr~~~~~~~~ 52 (57) T 2MFR_A 15 NIAKIIIGPLIFVFLFSVVIG--SIYLFLRKRQPDGPLEH 52 (57) T ss_dssp HHHHHHHHHHHHHHHHHHHHH--HHHHHHTSSCCCCSSSC T ss_pred hHHHHHHHHHHHHHHHHHHHH--HHHHHHhccCCCCCCCC Confidence 344555555544443332222 22344566777788874 No 56 >4U0Q_B Plasmodium falciparum Reticulocyte-binding protein homologue; Malaria Erythrocyte invasion, signaling protein; 3.1A {Plasmodium falciparum} Probab=67.25 E-value=4.2 Score=33.78 Aligned_cols=13 Identities=31% Similarity=0.493 Sum_probs=0.0 Template_Neff=12.500 Q sp|Q9BYF1|ACE2 744 IVFGVVMGVIVVG 756 (805) Q Consensus 744 ivfgvvmgvivvg 756 (805) +++|++++++++. T Consensus 211 ~~~~~~~~~~~~~ 223 (269) T 4U0Q_B 211 PFLGIVAEVLVLV 223 (269) T ss_dssp ------------- T ss_pred HHHHHHHHHHHHH Confidence 3445544444443 No 57 >5A2F_A CD166 ANTIGEN; CELL ADHESION, ALCAM, ACTIVATED LEUKOCYTE; HET: EDO, NAG; 1.86A {HOMO SAPIENS} Probab=63.73 E-value=5.5 Score=38.68 Aligned_cols=11 Identities=18% Similarity=0.585 Sum_probs=0.0 Template_Neff=11.600 Q sp|Q9BYF1|ACE2 589 EPLFTWLKDQN 599 (805) Q Consensus 589 eplftwlkdqn 599 (805) .|.++|.++.. T Consensus 442 ~~~i~W~~~~~ 452 (583) T 5A2F_A 442 KPAIQWTITGS 452 (583) T ss_dssp ----------- T ss_pred CCEEEEEECCc Confidence 35566766543 No 58 >2KLU_A T-cell surface glycoprotein CD4; Protein, Cell membrane, Disulfide bond; NMR {Homo sapiens} Probab=59.80 E-value=7.3 Score=30.35 Aligned_cols=9 Identities=56% Similarity=0.881 Sum_probs=3.7 Template_Neff=8.800 Q sp|Q9BYF1|ACE2 744 IVFGVVMGV 752 (805) Q Consensus 744 ivfgvvmgv 752 (805) +++|++.++ T Consensus 12 ~~vg~~~~~ 20 (70) T 2KLU_A 12 IVLGGVAGL 20 (70) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 344444443 No 59 >6ENY_C Beta-2-microglobulin, Tapasin, Protein disulfide-isomerase A3; adaptive immunity, antigen processing, chaperone; HET: BGC, MAN, NAG; 5.8A {Homo sapiens} Probab=58.02 E-value=8.2 Score=37.78 Aligned_cols=9 Identities=11% Similarity=-0.142 Sum_probs=4.5 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 539 LHKCDISNS 547 (805) Q Consensus 539 lhkcdisns 547 (805) .+.|.+.+. T Consensus 248 ~Y~C~~~~~ 256 (428) T 6ENY_C 248 TYLATIHLP 256 (428) T ss_pred EEEEEEEcC Confidence 455555443 No 60 >1S7Q_A H-2 class I histocompatibility antigen; LCMV, MHC class I, immune; 1.99A {Mus musculus} SCOP: d.19.1.1, b.1.1.2 Probab=57.91 E-value=8.2 Score=37.47 Aligned_cols=11 Identities=27% Similarity=0.314 Sum_probs=0.0 Template_Neff=9.700 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGV 752 (805) Q Consensus 742 wlivfgvvmgv 752 (805) +.++.+++.++ T Consensus 285 ~~~~~~~~~~~ 295 (348) T 1S7Q_A 285 ATVAVLVVLGA 295 (348) T ss_dssp ----------- T ss_pred HHHHHHHHHHH Confidence 43333444343 No 61 >1S7S_A H-2 class I histocompatibility antigen; LCMV, MHC class I, immune; 1.99A {Mus musculus} SCOP: d.19.1.1, b.1.1.2 Probab=57.91 E-value=8.2 Score=37.47 Aligned_cols=11 Identities=27% Similarity=0.314 Sum_probs=0.0 Template_Neff=9.700 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGV 752 (805) Q Consensus 742 wlivfgvvmgv 752 (805) +.++.+++.++ T Consensus 285 ~~~~~~~~~~~ 295 (348) T 1S7S_A 285 ATVAVLVVLGA 295 (348) T ss_dssp ----------- T ss_pred HHHHHHHHHHH Confidence 43333444343 No 62 >2WY3_A MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE; IMMUNE SYSTEM-VIRAL PROTEIN COMPLEX, IMMUNE; HET: PEU, NAG, ACT; 1.8A {HUMAN HERPESVIRUS 5 STRAIN AD169} Probab=57.28 E-value=8.6 Score=35.83 Aligned_cols=9 Identities=33% Similarity=0.674 Sum_probs=4.8 Template_Neff=10.500 Q sp|Q9BYF1|ACE2 591 LFTWLKDQN 599 (805) Q Consensus 591 lftwlkdqn 599 (805) .++|.++.. T Consensus 214 ~~~W~~~~~ 222 (319) T 2WY3_A 214 TLTWRQDGV 222 (319) T ss_pred EEEEEECCE Confidence 356666543 No 63 >6JXR_f T-cell surface glycoprotein CD3 zeta; IMMUNE SYSTEM;{Homo sapiens} Probab=55.13 E-value=9.8 Score=32.92 Aligned_cols=14 Identities=14% Similarity=-0.228 Sum_probs=6.0 Template_Neff=10.700 Q sp|Q9BYF1|ACE2 741 IWLIVFGVVMGVIV 754 (805) Q Consensus 741 iwlivfgvvmgviv 754 (805) +..|++|++.++++ T Consensus 130 i~~iv~g~~~~~l~ 143 (207) T 6JXR_f 130 VATIVIVDICITGG 143 (207) T ss_pred HHHHHHHHHHHHHH Confidence 33344554444333 No 64 >3LB6_C Interleukin-13, Interleukin-13 receptor subunit alpha-2; cytokine, receptor, decoy, decoy receptor; HET: NAG, MLY; 3.05A {Homo sapiens} Probab=54.78 E-value=10 Score=33.26 Aligned_cols=18 Identities=11% Similarity=0.165 Sum_probs=10.5 Template_Neff=12.600 Q sp|Q9BYF1|ACE2 670 VRVANLKPRISFNFFVTA 687 (805) Q Consensus 670 vrvanlkprisfnffvta 687 (805) ..+.+|+|.-.+.|-|.+ T Consensus 293 ~~~~~L~~~~~Y~~~V~a 310 (380) T 3LB6_C 293 YTLKTTNETRQLCFVVRS 310 (380) T ss_pred EEEecCCCCceEEEEEEE Confidence 445566666666665554 No 65 >3LB6_D Interleukin-13, Interleukin-13 receptor subunit alpha-2; cytokine, receptor, decoy, decoy receptor; HET: NAG; 3.05A {Homo sapiens} Probab=54.78 E-value=10 Score=33.26 Aligned_cols=18 Identities=11% Similarity=0.165 Sum_probs=7.8 Template_Neff=12.600 Q sp|Q9BYF1|ACE2 670 VRVANLKPRISFNFFVTA 687 (805) Q Consensus 670 vrvanlkprisfnffvta 687 (805) ..+.+|+|.-.+.|-|.+ T Consensus 293 ~~~~~L~~~~~Y~~~V~a 310 (380) T 3LB6_D 293 YTLKTTNETRQLCFVVRS 310 (380) T ss_dssp EEECC----CCEEEEEEE T ss_pred EEEecCCCCceEEEEEEE Confidence 445566666666665554 No 66 >6FGB_A IgG receptor FcRn large subunit; FcRn, rozanolixizumab, ECD, Fab, immune; 2.9A {Homo sapiens} Probab=49.49 E-value=14 Score=35.50 Aligned_cols=10 Identities=10% Similarity=-0.157 Sum_probs=4.5 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 776 SGENPYASID 785 (805) Q Consensus 776 sgenpyasid 785 (805) +..+++.+++ T Consensus 311 ~~~~~~~~~~ 320 (342) T 6FGB_A 311 SLRGDDTGVL 320 (342) T ss_pred cCCCCCCCCc Confidence 3344555443 No 67 >4NKQ_B Cytokine receptor common subunit beta; GM-CSF, receptor complex, dodecamer, Disease; HET: NAG; 3.301A {Homo sapiens} Probab=46.89 E-value=16 Score=32.21 Aligned_cols=18 Identities=17% Similarity=0.263 Sum_probs=10.6 Template_Neff=11.700 Q sp|Q9BYF1|ACE2 670 VRVANLKPRISFNFFVTA 687 (805) Q Consensus 670 vrvanlkprisfnffvta 687 (805) ..+.+|+|...+.|-|.+ T Consensus 186 ~~l~~L~p~t~Y~~~V~a 203 (305) T 4NKQ_B 186 YNFPSSEPRAKHSVKIRA 203 (305) T ss_pred EEccCCCCCCcEEEEEEE Confidence 345566666666665554 No 68 >6JXR_g T-cell surface glycoprotein CD3 zeta; IMMUNE SYSTEM;{Homo sapiens} Probab=43.82 E-value=20 Score=29.72 Aligned_cols=10 Identities=10% Similarity=0.408 Sum_probs=4.0 Template_Neff=11.300 Q sp|Q9BYF1|ACE2 743 LIVFGVVMGV 752 (805) Q Consensus 743 livfgvvmgv 752 (805) .|++|++.++ T Consensus 117 ~i~~~~~~~~ 126 (182) T 6JXR_g 117 GFLFAEIVSI 126 (182) T ss_pred HHHHHHHHHH Confidence 3444443333 No 69 >5EH6_A Glycophorin-A; Receptor, lipidic cubic phase, peptides; 1.918A {Homo sapiens} Probab=43.27 E-value=20 Score=28.46 Aligned_cols=24 Identities=58% Similarity=1.035 Sum_probs=18.2 Template_Neff=2.200 Q sp|Q9BYF1|ACE2 741 IWLIVFGVVMGVIVVGIVILIFTGIR 766 (805) Q Consensus 741 iwlivfgvvmgvivvgiviliftgir 766 (805) |.+|+|||..|| +|.++||-..|| T Consensus 4 I~lII~~vmagv--ig~ILlI~y~I~ 27 (30) T 5EH6_A 4 ITLIIFGVIAGV--IGTILLISYGIR 27 (30) T ss_dssp HHHHHHHHHHHH--HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH--HHHHHHHHHHHH Confidence 778999999987 466666666665 No 70 >5EH4_C Glycophorin-A; Receptor, lipidic cubic phase, peptides; HET: SCH, OLB; 2.81A {Homo sapiens} Probab=43.27 E-value=20 Score=28.46 Aligned_cols=24 Identities=58% Similarity=1.035 Sum_probs=18.2 Template_Neff=2.200 Q sp|Q9BYF1|ACE2 741 IWLIVFGVVMGVIVVGIVILIFTGIR 766 (805) Q Consensus 741 iwlivfgvvmgvivvgiviliftgir 766 (805) |.+|+|||..|| +|.++||-..|| T Consensus 4 I~lII~~vmagv--ig~ILlI~y~I~ 27 (30) T 5EH4_C 4 ITLIIFGVIAGV--IGTILLISYGIR 27 (30) T ss_dssp HHHHHHHHHHHH--HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH--HHHHHHHHHHHH Confidence 778999999987 466666666665 No 71 >2XQ2_A SODIUM/GLUCOSE COTRANSPORTER; TRANSPORT PROTEIN, INVERTED REPEATS, LEUT-FOLD; HET: PEG; 2.73A {VIBRIO PARAHAEMOLYTICUS} Probab=39.81 E-value=25 Score=38.03 Aligned_cols=33 Identities=45% Similarity=0.708 Sum_probs=25.2 Template_Neff=8.700 Q sp|Q9BYF1|ACE2 739 VSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNK 773 (805) Q Consensus 739 vsiwlivfgvvmgvivvgiviliftgirdrkkknk 773 (805) .-||+|+|||..||| |++.+|-.+||.-.||+. T Consensus 548 ~~~~~~~~~~~~~~~--~~~~~~~~~~~~~~~~~~ 580 (593) T 2XQ2_A 548 AEITLIIFGVMAGVI--GTILLISYGIKKLIKASY 580 (593) T ss_pred HHHHHHHHHHHHHHH--HHHHHHHHHHHHHhhcCC Confidence 346999999998865 677788888887666653 No 72 >2RDD_B Acriflavine resistance protein B, UPF0092; DRUG RESISTANCE, MULTIDRUG EFFLUX, TRANSPORTER; HET: AIC; 3.5A {Escherichia coli} Probab=39.22 E-value=26 Score=26.11 Aligned_cols=20 Identities=25% Similarity=0.323 Sum_probs=11.5 Template_Neff=6.900 Q sp|Q9BYF1|ACE2 756 GIVILIFTGIRDRKKKNKAR 775 (805) Q Consensus 756 giviliftgirdrkkknkar 775 (805) .++++.|.-+|..||+.|++ T Consensus 12 ~~~~~~~~~~rpqkK~~k~~ 31 (37) T 2RDD_B 12 FGLIFYFMILRPQQKRTKEH 31 (37) T ss_dssp HHHHHHHHTHHHHHHHHHHH T ss_pred HHHHHHHHHHCHHHHHHHHH Confidence 34445555667766666554 No 73 >6CPL_A HLA class II histocompatibility antigen; IMMUNE RECEPTOR, IMMUNE SYSTEM; HET: NAG, SO4; 2.45A {Homo sapiens} Probab=39.13 E-value=26 Score=31.32 Aligned_cols=8 Identities=38% Similarity=0.904 Sum_probs=4.3 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 591 LFTWLKDQ 598 (805) Q Consensus 591 lftwlkdq 598 (805) -.+|.++. T Consensus 118 ~v~W~~~~ 125 (229) T 6CPL_A 118 NVTWLRNG 125 (229) T ss_pred EEEEEECC Confidence 45666554 No 74 >6EJ2_A Beta-secretase 1 (E.C.3.4.23.46); BACE1, protease, Alzheimer, PEPTIDE BINDING; HET: B7E; 1.46A {Homo sapiens} Probab=38.02 E-value=28 Score=35.18 Aligned_cols=15 Identities=7% Similarity=0.138 Sum_probs=0.0 Template_Neff=10.200 Q sp|Q9BYF1|ACE2 736 QPPVSIWLIVFGVVM 750 (805) Q Consensus 736 qppvsiwlivfgvvm 750 (805) ....++..|+.++|- T Consensus 452 ~~~~~~~~ivg~~vg 466 (501) T 6EJ2_A 452 ESTLMTIAYVMAAIC 466 (501) T ss_dssp --------------- T ss_pred CCcchHHHHHHHHHH Confidence 334444444444333 No 75 >6ENY_F Beta-2-microglobulin, Tapasin, Protein disulfide-isomerase A3; adaptive immunity, antigen processing, chaperone; HET: NAG, MAN, BGC; 5.8A {Homo sapiens} Probab=37.88 E-value=28 Score=33.91 Aligned_cols=6 Identities=50% Similarity=1.359 Sum_probs=2.8 Template_Neff=9.700 Q sp|Q9BYF1|ACE2 592 FTWLKD 597 (805) Q Consensus 592 ftwlkd 597 (805) .+|.++ T Consensus 215 v~W~~~ 220 (341) T 6ENY_F 215 LTWQRD 220 (341) T ss_dssp EEEEET T ss_pred EEEEeC Confidence 445444 No 76 >5XTH_0 NADH dehydrogenase [ubiquinone] flavoprotein 1; Homo sapiens, Oxidoreductase, Respiratory, Supercomplex; HET: PEE, CDL, HEA, HEC, FES, PLX, 8Q1, HEM, NDP, SF4, FMN; 3.9A {Homo sapiens} Probab=37.10 E-value=29 Score=33.41 Aligned_cols=32 Identities=22% Similarity=0.281 Sum_probs=22.9 Template_Neff=5.900 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFT 763 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgivilift 763 (805) ||+-++|..-|-.|+|.++++|.+++++.++. T Consensus 65 ~~e~~~p~g~wK~v~~~v~~~~~~s~~lf~~~ 96 (144) T 5XTH_0 65 FAEMNRSTNEWKTVVGAAMFFIGFTALLLIWE 96 (144) T ss_pred cccccCCCchHHHHHHHHHHHHHHHHHHHHHH Confidence 45667888889888888887776666555543 No 77 >5B1A_D Cytochrome c oxidase subunit 1; Oxidoreductase, Proton pump, Heme, Respiratory; HET: FME, CDL, TGL, HEA, PGV, CHD, PSC, PEK, DMU, TPO, SAC; 1.5A {Bos taurus} Probab=33.75 E-value=36 Score=33.09 Aligned_cols=32 Identities=22% Similarity=0.281 Sum_probs=22.9 Template_Neff=5.700 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFT 763 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgivilift 763 (805) ||+-++|...|-.|||.+++++.+++++.++. T Consensus 68 gp~~~~p~~~~k~v~~~~~~~~~~s~~l~~~~ 99 (147) T 5B1A_D 68 FAEMNRSTNEWKTVVGAAMFFIGFTALLLIWE 99 (147) T ss_dssp HHHHTCCCSHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cccccCCCchHHHHHHHHHHHHHHHHHHHHHH Confidence 55667888889888888877776666555543 No 78 >6PY2_A HLA class II histocompatibility antigen; HLA, MHC, TCR, Gluten, IMMUNE; HET: NAG, GOL; 2.82543430029A {Homo sapiens} Probab=33.31 E-value=37 Score=31.36 Aligned_cols=9 Identities=33% Similarity=0.785 Sum_probs=5.7 Template_Neff=10.000 Q sp|Q9BYF1|ACE2 591 LFTWLKDQN 599 (805) Q Consensus 591 lftwlkdqn 599 (805) -++|.++.. T Consensus 143 ~v~W~~~g~ 151 (254) T 6PY2_A 143 NITWLSNGH 151 (254) T ss_dssp EEEEEETTE T ss_pred EEEEEECCE Confidence 477777643 No 79 >6GJE_A Protein amnionless, Cubilin; receptor, vitamin B12, cubilin, amnionless; 2.3A {Homo sapiens} Probab=33.17 E-value=37 Score=37.81 Aligned_cols=18 Identities=28% Similarity=0.311 Sum_probs=0.0 Template_Neff=6.100 Q sp|Q9BYF1|ACE2 783 SIDISKGENNPGFQNTDD 800 (805) Q Consensus 783 sidiskgennpgfqntdd 800 (805) .-...+|-.||-|....+ T Consensus 399 ~~~~~~gf~NP~fd~~~~ 416 (453) T 6GJE_A 399 PAGAPLGFRNPVFDVTAS 416 (453) T ss_dssp ------------------ T ss_pred CCCCCCCcCCccccCCCC Confidence 556778889998877644 No 80 >6C13_A Protocadherin-15; PCDH15, LHFPL5, protocadherin, tip link; HET: MAN, BMA, NAG;{Mus musculus} Probab=32.87 E-value=38 Score=34.96 Aligned_cols=13 Identities=31% Similarity=0.317 Sum_probs=6.8 Template_Neff=10.700 Q sp|Q9BYF1|ACE2 693 DIIPRTEVEKAIR 705 (805) Q Consensus 693 diiprtevekair 705 (805) .++.+.++.+.+. T Consensus 508 ~i~~~~~~~~~l~ 520 (660) T 6C13_A 508 RAIDRNELFKFLD 520 (660) T ss_dssp EECCHHHHHHHHH T ss_pred eEecHHHHHHHHh Confidence 3555555555544 No 81 >5DJQ_P Cbb3-type cytochrome c oxidase subunit; oxidoreductase, cbb3-cytochrome c oxidase, Pseudomonas_stutzeri; HET: PO4, HEC, FC6, HEM; 3.2A {Pseudomonas stutzeri} Probab=32.78 E-value=38 Score=27.68 Aligned_cols=24 Identities=42% Similarity=0.845 Sum_probs=13.0 Template_Neff=3.100 Q sp|Q9BYF1|ACE2 748 VVMGVIVVGIVILIFTGI-----RDRKKK 771 (805) Q Consensus 748 vvmgvivvgiviliftgi-----rdrkkk 771 (805) |+.|+++||..++.|.|. ||.+|| T Consensus 7 ViaGi~tVglm~~Ff~G~g~FIwkD~~k~ 35 (36) T 5DJQ_P 7 VLAGVVTVGLMVAFLAGFGYFIWRDAHKK 35 (36) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHC------ T ss_pred HHHHHHHHHHHHHHHHHHHHHHhHhhhhc Confidence 566777788877777764 555554 No 82 >1CD1_A CD1; CD1, IMMUNOLOGY, MHC, TCR, GLYCOPROTEIN; 2.67A {Mus musculus} SCOP: b.1.1.2, d.19.1.1 Probab=32.51 E-value=39 Score=31.77 Aligned_cols=7 Identities=14% Similarity=0.961 Sum_probs=3.3 Template_Neff=10.400 Q sp|Q9BYF1|ACE2 592 FTWLKDQ 598 (805) Q Consensus 592 ftwlkdq 598 (805) .+|+++. T Consensus 217 v~W~~~g 223 (315) T 1CD1_A 217 VMWMRGD 223 (315) T ss_dssp EEEEETT T ss_pred EEEEECC Confidence 4555443 No 83 >6AT5_A HLA class I histocompatibility antigen; Human Leukocyte Antigen, Major histocompatibility; 1.5A {Homo sapiens} Probab=29.91 E-value=46 Score=33.01 Aligned_cols=8 Identities=38% Similarity=0.924 Sum_probs=4.5 Template_Neff=9.500 Q sp|Q9BYF1|ACE2 591 LFTWLKDQ 598 (805) Q Consensus 591 lftwlkdq 598 (805) -.+|.++. T Consensus 238 ~v~W~~~g 245 (362) T 6AT5_A 238 TLTWQRDG 245 (362) T ss_dssp EEEEEETT T ss_pred EEEEEeCC Confidence 35666653 No 84 >4JIX_A Uncharacterized protein MJ0123; Hydrolase, Metallopeptidase Zymogen, Minigluzincin; HET: GOL, SO4; 2.0A {Methanocaldococcus jannaschii} Probab=28.17 E-value=51 Score=27.66 Aligned_cols=41 Identities=20% Similarity=0.211 Sum_probs=24.4 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 371 TAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSI 421 (805) Q Consensus 371 tahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlksi 421 (805) +--|||+|+... ..+-+..|...+..++.-...--+.|+.. T Consensus 68 vi~HEl~H~~~~----------~~~H~~~f~~~~~~~~p~~~~~~~~l~~~ 108 (112) T 4JIX_A 68 IILHELIHFKIK----------SINHGIKFENELRNYFSKNECDEIELKII 108 (112) T ss_dssp HHHHHHHHHHHT----------CSSCSHHHHHHHTTTCCHHHHHHHHHHHH T ss_pred HHHHHHHHHHhh----------cccccHHHHHHHHHHcccchhhHHHHHHH Confidence 557999999762 23334567777766665544444444443 No 85 >4JIX_B Projannalysin; Hydrolase, Metallopeptidase Zymogen, Minigluzincin; HET: SO4, GOL; 2.0A {Methanocaldococcus jannaschii} Probab=28.17 E-value=51 Score=27.66 Aligned_cols=41 Identities=20% Similarity=0.211 Sum_probs=24.4 Template_Neff=9.100 Q sp|Q9BYF1|ACE2 371 TAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSI 421 (805) Q Consensus 371 tahhemghiqydmayaaqpfllrnganegfheavgeimslsaatpkhlksi 421 (805) +--|||+|+... ..+-+..|...+..++.-...--+.|+.. T Consensus 68 vi~HEl~H~~~~----------~~~H~~~f~~~~~~~~p~~~~~~~~l~~~ 108 (112) T 4JIX_B 68 IILHELIHFKIK----------SINHGIKFENELRNYFSKNECDEIELKII 108 (112) T ss_dssp HHHHHHHHHHHT----------CSCCSHHHHHHHTTTCCHHHHHHHHHHHH T ss_pred HHHHHHHHHHhh----------cccccHHHHHHHHHHcccchhhHHHHHHH Confidence 557999999762 23334567777766665544444444443 No 86 >6IDF_E Nicastrin, Presenilin-1 (E.C.3.4.23.-), Gamma-secretase subunit; complex, MEMBRANE PROTEIN; HET: BMA, NAG, CLR, PC1;{Homo sapiens} Probab=27.63 E-value=53 Score=31.80 Aligned_cols=16 Identities=6% Similarity=0.139 Sum_probs=7.4 Template_Neff=5.100 Q sp|Q9BYF1|ACE2 733 PPNQPPVSIWLIVFGV 748 (805) Q Consensus 733 ppnqppvsiwlivfgv 748 (805) ||..++...|+++.|+ T Consensus 9 ~~~~~~~~~~~v~i~~ 24 (129) T 6IDF_E 9 CPPPAQLHFMYVAAAA 24 (129) T ss_dssp SCCCCSSSHHHHHHTH T ss_pred CCCChhhHHHHHHHHH Confidence 3333344456555444 No 87 >6IVA_D Oxaloacetate decarboxylase beta chain (E.C.7.2.4.2); membrane protein, decarboxylase sodium pump; 4.403A {Salmonella enterica I} Probab=26.48 E-value=58 Score=29.72 Aligned_cols=27 Identities=11% Similarity=0.212 Sum_probs=12.5 Template_Neff=6.300 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIFTG 764 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgiviliftg 764 (805) .+.+-++.+|+|+.++++.++++.+.+ T Consensus 31 ~l~i~iiGm~vVF~vLilL~lvi~l~~ 57 (104) T 6IVA_D 31 GFTLMFLGMGFVLAFLFLLIFAIRGMS 57 (104) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 344445555555555444444333333 No 88 >6IWW_B Oxaloacetate decarboxylase beta chain (E.C.7.2.4.2); membrane protein, sodium pump, decarboxylase; HET: LMT; 3.9A {Salmonella enterica subsp. enterica} Probab=26.48 E-value=58 Score=29.72 Aligned_cols=27 Identities=11% Similarity=0.212 Sum_probs=12.5 Template_Neff=6.300 Q sp|Q9BYF1|ACE2 738 PVSIWLIVFGVVMGVIVVGIVILIFTG 764 (805) Q Consensus 738 pvsiwlivfgvvmgvivvgiviliftg 764 (805) .+.+-++.+|+|+.++++.++++.+.+ T Consensus 31 ~l~i~iiGm~vVF~vLilL~lvi~l~~ 57 (104) T 6IWW_B 31 GFTLMFLGMGFVLAFLFLLIFAIRGMS 57 (104) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 344445555555555444444333333 No 89 >6BRJ_A Epithelial discoidin domain-containing receptor 1; Kinase, Inhibitor, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR; HET: VX6; 2.231A {Homo sapiens} Probab=25.27 E-value=63 Score=37.06 Aligned_cols=7 Identities=57% Similarity=1.545 Sum_probs=0.0 Template_Neff=8.500 Q sp|Q9BYF1|ACE2 602 SFVGWST 608 (805) Q Consensus 602 sfvgwst 608 (805) .||||+. T Consensus 254 ~~~~~~~ 260 (876) T 6BRJ_A 254 DYVGWSN 260 (876) T ss_dssp ------- T ss_pred Ceeeeec Confidence 4555543 No 90 >3EHB_B Cytochrome c oxidase subunit 1-beta; proton pumping, water chain, electron; HET: LDA, LMT, HEA; 2.32A {Paracoccus denitrificans} SCOP: f.17.2.1, b.6.1.2 Probab=25.21 E-value=63 Score=33.82 Aligned_cols=47 Identities=15% Similarity=0.255 Sum_probs=20.2 Template_Neff=6.800 Q sp|Q9BYF1|ACE2 725 LGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 725 lgiqptlgppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkk 771 (805) +|.|+..+|..+.-...+-.++.+++.+.++..+++++.-+|-|+++ T Consensus 47 ~~~~~~as~~a~~i~~L~~~~l~i~~~I~v~V~~ll~~~i~ryr~~~ 93 (298) T 3EHB_B 47 MNFQPASSPLAHDQQWLDHFVLYIITAVTIFVCLLLLICIVRFNRRA 93 (298) T ss_pred cCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHchhcC Confidence 55666665555544444433333322222222223334444555443 No 91 >6PY2_B HLA class II histocompatibility antigen; HLA, MHC, TCR, Gluten, IMMUNE; HET: NAG, GOL; 2.82543430029A {Homo sapiens} Probab=24.26 E-value=67 Score=30.09 Aligned_cols=11 Identities=36% Similarity=0.760 Sum_probs=0.0 Template_Neff=9.800 Q sp|Q9BYF1|ACE2 745 VFGVVMGVIVV 755 (805) Q Consensus 745 vfgvvmgvivv 755 (805) ++|++++++++ T Consensus 235 ~~~~~~~l~~~ 245 (261) T 6PY2_B 235 IGGFVLGLIFL 245 (261) T ss_dssp ----------- T ss_pred HHHHHHHHHHH Confidence 44555555444 No 92 >1Q5B_C EP-cadherin, ectodomain; CADHERIN TRANS INTERACTION ; HET: NDG, NAG, CA; 30.0A {Mus musculus} SCOP: i.20.1.1 Probab=24.14 E-value=68 Score=34.98 Aligned_cols=12 Identities=25% Similarity=0.495 Sum_probs=3.1 Template_Neff=10.300 Q sp|Q9BYF1|ACE2 155 SLDYNERLWAWE 166 (805) Q Consensus 155 sldynerlwawe 166 (805) .+....|-|.|. T Consensus 149 ~~~r~~~~~~~~ 160 (880) T 1Q5B_C 149 GLKRKKRDWVIP 160 (880) T ss_dssp -------CCBCC T ss_pred CCccCCcceeCC Confidence 344455666654 No 93 >2JO1_A Phospholemman; FXYD1, Na,K-ATPase, Micelle, HYDROLASE REGULATOR; NMR {Homo sapiens} Probab=23.89 E-value=69 Score=29.34 Aligned_cols=30 Identities=33% Similarity=0.345 Sum_probs=11.7 Template_Neff=3.400 Q sp|Q9BYF1|ACE2 747 GVVMGVIVVGIVILIFTGIRDRKKKNKARS 776 (805) Q Consensus 747 gvvmgvivvgiviliftgirdrkkknkars 776 (805) |++++++...+.|+|.++-|-|-+.|+.++ T Consensus 20 GLi~A~vLfi~GIliils~kckC~~~q~~~ 49 (72) T 2JO1_A 20 GLVIAGILFILGILIVLSRRCRCKFNQQQR 49 (72) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCTTTS T ss_pred HHHHHHHHHHHHHHHHHhccccccCCcCCC Confidence 444333333333333334444444444333 No 94 >2KV5_A Putative uncharacterized protein RNAI; toxin-antitoxin, bacterial, toxin; NMR {N/A} Probab=23.51 E-value=71 Score=25.42 Aligned_cols=27 Identities=22% Similarity=0.514 Sum_probs=19.0 Template_Neff=4.000 Q sp|Q9BYF1|ACE2 745 VFGVVMGVIVVGIVILIFTGIRD-RKKK 771 (805) Q Consensus 745 vfgvvmgvivvgiviliftgird-rkkk 771 (805) +|-.+++-|+||+++-+|+-.-| |.+| T Consensus 4 if~~IiapiivG~vv~lf~~WL~~r~~k 31 (33) T 2KV5_A 4 LMSLVIAPIFVGLVLEMISRVLDEEDDS 31 (33) T ss_dssp THHHHHHHHHHHHHHHHHHHHTTCCCCC T ss_pred HHHHhHHHHHHHHHHHHHHHHHHhcccc Confidence 45567788889999988886544 4443 No 95 >6BSD_A Epithelial discoidin domain-containing receptor 1; Kinase, Inhibitor, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR; HET: 1N1; 2.606A {Homo sapiens} Probab=23.31 E-value=72 Score=36.61 Aligned_cols=7 Identities=57% Similarity=1.545 Sum_probs=3.5 Template_Neff=8.500 Q sp|Q9BYF1|ACE2 602 SFVGWST 608 (805) Q Consensus 602 sfvgwst 608 (805) .||||+. T Consensus 254 ~~~~~~~ 260 (876) T 6BSD_A 254 DYVGWSN 260 (876) T ss_pred Ceeeeec Confidence 4555543 No 96 >6KOE_F AA3-600 quinol oxidase subunit I; Menaquinol oxidase, Complex, Proton pumping; HET: HQO, HEA; 3.75A {Bacillus subtilis} Probab=22.61 E-value=76 Score=33.75 Aligned_cols=40 Identities=20% Similarity=0.404 Sum_probs=17.8 Template_Neff=6.100 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkk 771 (805) ||..+.-..++++.+++.+.|+++.++++++..+|-|+++ T Consensus 11 gp~a~~~~~l~~~~~~~~l~i~v~V~~l~~~~~~rYR~~~ 50 (296) T 6KOE_F 11 GPVAEQQSDLILLSIGFMLFIVGVVFVLFTIILVKYRDRK 50 (296) T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHchhcC Confidence 4444333333444444444443333444444556655554 No 97 >6KOB_B AA3-600 quinol oxidase subunit I; Menaquinol oxidase, Complex, Proton pumping; HET: MQ7, HEA; 3.6A {Bacillus subtilis} Probab=22.61 E-value=76 Score=33.75 Aligned_cols=40 Identities=20% Similarity=0.404 Sum_probs=15.7 Template_Neff=6.100 Q sp|Q9BYF1|ACE2 732 GPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKK 771 (805) Q Consensus 732 gppnqppvsiwlivfgvvmgvivvgiviliftgirdrkkk 771 (805) ||..+.-..++++.+++.+.|+++.++++++..+|-|+++ T Consensus 11 gp~a~~~~~l~~~~~~~~l~i~v~V~~l~~~~~~rYR~~~ 50 (296) T 6KOB_B 11 GPVAEQQSDLILLSIGFMLFIVGVVFVLFTIILVKYRDRK 50 (296) T ss_dssp -----CTTHHHHHHHHHHHHHHHHHHHHTTTSSSSSSCCC T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHchhcC Confidence 4444333333444444444443333444444556655554 No 98 >1Q90_G Apocytochrome f, Cytochrome b6, Cytochrome; MEMBRANE PROTEIN COMPLEX, PHOTOSYNTHESIS, ELECTRON; HET: LFA, CLA, BCR, SQD, LMG, HEM, TDS; 3.1A {Chlamydomonas reinhardtii} SCOP: f.23.26.1 Probab=22.36 E-value=78 Score=26.34 Aligned_cols=29 Identities=24% Similarity=0.430 Sum_probs=22.3 Template_Neff=2.400 Q sp|Q9BYF1|ACE2 744 IVFGVVMGVIVVGIVILIFTGIRDRKKKN 772 (805) Q Consensus 744 ivfgvvmgvivvgiviliftgirdrkkkn 772 (805) +.+|+|.|.|.|.++-|.++....-++.+ T Consensus 5 lL~GIVlGli~iTlaGLfv~AY~QyrRg~ 33 (37) T 1Q90_G 5 LLCGIVLGLVPVTIAGLFVTAYLQYLRGD 33 (37) T ss_pred hHHHHHHHhHHHHHHHHHHHHHHHHHhcc Confidence 57899999999998888888765544433 No 99 >2GSM_B Cytochrome c oxidase subunit 1; transmembrane protein complex, OXIDOREDUCTASE; HET: TRD, DMU, HEA; 2.0A {Rhodobacter sphaeroides} SCOP: f.17.2.1, b.6.1.2 Probab=21.90 E-value=80 Score=31.85 Aligned_cols=6 Identities=67% Similarity=1.121 Sum_probs=2.5 Template_Neff=7.600 Q sp|Q9BYF1|ACE2 721 SLEFLG 726 (805) Q Consensus 721 sleflg 726 (805) ||++.| T Consensus 4 ~~~~~~ 9 (262) T 2GSM_B 4 SLEIIG 9 (262) T ss_dssp -CCEEE T ss_pred ccccCC Confidence 455544 No 100 >3HB3_B Cytochrome c oxidase subunit 1-beta; Electron transfer, Proton transfer, Proton; HET: HEA, LDA, LMT; 2.25A {Paracoccus denitrificans} Probab=21.53 E-value=83 Score=32.92 Aligned_cols=47 Identities=15% Similarity=0.280 Sum_probs=18.3 Template_Neff=6.900 Q sp|Q9BYF1|ACE2 725 LGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIV-ILIFTGIRDRKKKN 772 (805) Q Consensus 725 lgiqptlgppnqppvsiwlivfgvvmgvivvgiv-iliftgirdrkkkn 772 (805) ++.|+..+|-.+.-...+-+++++. .+|++++. ++++.-+|-|++++ T Consensus 47 ~~~~~~aS~~a~~i~~L~~~~~~i~-~~Ifv~V~~ll~~~i~ryr~~~~ 94 (298) T 3HB3_B 47 MNFQPASSPLAHDQQWLDHFVLYII-TAVTIFVCLLLLICIVRFNRRAN 94 (298) T ss_dssp CSCSCCCSHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHSBTTTS T ss_pred CCCCCCCCHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHccccCC Confidence 3444444444443333333333332 22222222 23333355555443 No 101 >5X5V_A GD; herpes simplex virus, pseudorabies virus; 1.5A {Suid herpesvirus 1} Probab=20.11 E-value=93 Score=35.59 Aligned_cols=28 Identities=32% Similarity=0.647 Sum_probs=0.0 Template_Neff=3.400 Q sp|Q9BYF1|ACE2 742 WLIVFGVVMGVIVVGIVILIFTGIRDRK 769 (805) Q Consensus 742 wlivfgvvmgvivvgiviliftgirdrk 769 (805) ..+-.|+.||.|+||+.+.||..+|..| T Consensus 355 v~vgvg~~~~~~~~~~~~~~~~~~~~~~ 382 (402) T 5X5V_A 355 VIVGTGTAMGALLVGVCVYIFFRLRGAK 382 (402) T ss_dssp ---------------------------- T ss_pred eehhHHHHHHHHHHHHHHHHHHHccccc Confidence 3456799999999999999998877654 Query sp|P0DTC2|SPIKE_SARS2 Spike glycoprotein OS=Severe acute respiratory syndrome coronavirus 2 OX=2697049 GN=S PE=1 SV=1 Match_columns 1273 No_of_seqs 1 out of 1 Neff 1 Searched_HMMs 82491 Date Thu Nov 12 20:44:30 2020 Command hhsearch -e 0.001 -i /galaxy-repl/main/files/047/416/dataset_47416633.dat -d hhdb -o /galaxy-repl/main/files/047/416/dataset_47416669.dat No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 6X29_A Spike glycoprotein; Tri 100.0 3E-269 4E-274 2251.1 0.0 1198 16-1213 1-1198(1273) 2 6CS2_B Spike glycoprotein,Enve 100.0 3E-221 4E-226 1857.5 0.0 1161 31-1213 22-1182(1215) 3 6Q04_B Spike glycoprotein; Cor 100.0 2E-204 2E-209 1723.9 0.0 1150 31-1224 65-1321(1359) 4 5I08_C Spike glycoprotein; cor 100.0 2E-199 2E-204 1685.1 0.0 1142 30-1223 29-1293(1299) 5 5X5F_B S protein; MERS-CoV, sp 100.0 6E-198 7E-203 1670.1 0.0 1163 14-1220 12-1286(1323) 6 6VSJ_A Spike glycoprotein, Car 100.0 2E-195 3E-200 1649.5 0.0 1145 9-1204 22-1267(1275) 7 6VSJ_C Spike glycoprotein, Car 100.0 2E-195 3E-200 1649.5 0.0 1145 9-1204 22-1267(1275) 8 6OHW_A Spike surface glycoprot 100.0 7E-190 9E-195 1602.1 0.0 1144 2-1204 13-1299(1322) 9 6NZK_A Spike surface glycoprot 100.0 7E-190 9E-195 1602.1 0.0 1144 2-1204 13-1299(1322) 10 6M15_A Spike glycoprotein; VIR 100.0 6E-154 7E-159 1294.0 0.0 832 273-1215 216-1070(1118) 11 6M15_B Spike glycoprotein; VIR 100.0 6E-154 7E-159 1294.0 0.0 832 273-1215 216-1070(1118) 12 6JX7_A Feline Infectious Perit 100.0 2E-132 2E-137 1149.2 0.0 664 525-1216 674-1394(1468) 13 5SZS_A Spike glycoprotein; cor 100.0 7E-131 9E-136 1128.9 0.0 662 505-1215 575-1283(1325) 14 6IXB_B Spike glycoprotein; Alp 100.0 8E-129 1E-133 1101.7 0.0 647 518-1214 426-1116(1116) 15 6CV0_A Spike protein; infectio 100.0 3E-125 3E-130 1068.9 0.0 651 524-1212 399-1074(1105) 16 6VV5_C Spike glycoprotein; gly 100.0 2E-124 2E-129 1078.6 0.0 641 521-1213 614-1309(1356) 17 6M3W_B Spike glycoprotein,Spik 100.0 2E-124 2E-129 1000.4 0.0 491 706-1196 1-491 (491) 18 6U7K_C Spike glycoprotein; PED 100.0 1E-122 1E-127 1065.5 0.0 641 521-1213 629-1324(1399) 19 6BFU_C Spike protein; coronavi 100.0 4E-119 4E-124 1017.5 0.0 746 267-1148 240-1022(1024) 20 6B3O_B Spike glycoprotein; Cor 100.0 7E-117 9E-122 954.9 0.0 497 703-1203 45-560 (605) 21 6PZ8_A S protein, G2 heavy cha 100.0 8E-112 1E-116 897.4 0.0 445 694-1140 12-470 (472) 22 6PZ8_F S protein, G2 heavy cha 100.0 3.1E-74 3.8E-79 636.3 0.0 621 14-676 12-724 (726) 23 7BZ5_A Spike protein S1, Heavy 100.0 3.5E-52 4.2E-57 416.5 0.0 225 319-543 1-225 (229) 24 6YZ5_E Spike glycoprotein, Nan 100.0 3.5E-51 4.3E-56 405.6 0.0 205 330-534 1-205 (210) 25 6YLA_E SARS-CoV-2 RBD, Heavy C 100.0 3.8E-51 4.6E-56 406.0 0.0 207 328-534 2-208 (213) 26 6ZFO_A SARS-CoV-2 RBD, Nanobod 100.0 2.3E-47 2.8E-52 375.2 0.0 194 333-526 1-194 (194) 27 2GHV_C Spike glycoprotein; SAR 100.0 3.9E-37 4.7E-42 305.0 0.0 197 330-527 4-200 (203) 28 1WYY_A E2 Glycoprotein; membra 100.0 2.3E-36 2.8E-41 288.5 0.0 99 903-1001 3-101 (149) 29 1WYY_B E2 Glycoprotein; membra 100.0 2.3E-36 2.8E-41 288.5 0.0 99 903-1001 3-101 (149) 30 5X4S_A Spike glycoprotein; SAR 100.0 1.1E-34 1.4E-39 298.0 0.0 261 30-307 21-281 (285) 31 5KWB_A Spike glycoprotein; Cor 100.0 1.2E-33 1.4E-38 297.9 0.0 271 316-592 1-370 (371) 32 6LXT_F Spike protein S2; 2019- 99.9 2.8E-28 3.4E-33 230.5 0.0 112 910-1021 1-113 (132) 33 6LXT_C 2019-nCoV S2 subunit; 2 99.9 2.8E-28 3.4E-33 230.5 0.0 112 910-1021 1-113 (132) 34 6C6Z_A Spike protein, CDC2-C2 99.9 6.9E-26 8.3E-31 228.8 0.0 148 319-472 1-148 (231) 35 5XGR_H Spike protein S1; MERS- 99.8 9.7E-26 1.2E-30 224.7 0.0 181 335-528 2-198 (204) 36 4QZV_B Dipeptidyl peptidase 4 99.8 4.1E-25 5E-30 224.7 0.0 137 319-458 1-139 (246) 37 4L3N_B S protein; beta-sheet f 99.8 2.3E-24 2.8E-29 216.3 0.0 124 334-458 3-126 (216) 38 5YY5_B MERS-CoV RBD, Heavy cha 99.8 3.5E-24 4.2E-29 214.4 0.0 124 334-458 2-125 (209) 39 4L72_B Dipeptidyl peptidase 4 99.8 4E-24 4.8E-29 213.4 0.0 123 335-458 1-123 (204) 40 3R4D_D CEA-related cell adhesi 99.8 5.2E-24 6.3E-29 219.9 0.0 240 30-304 30-283 (288) 41 4NJL_A S protein; six-helix-bu 99.8 1.2E-23 1.4E-28 199.4 0.0 122 910-1035 2-125 (131) 42 6QFY_A Spike glycoprotein; sia 99.8 2.6E-23 3.2E-28 214.7 0.0 236 30-305 29-286 (288) 43 4H14_A Spike glycoprotein; bet 99.8 3.5E-23 4.3E-28 214.0 0.0 235 30-304 29-285 (290) 44 4MOD_B HR1 of S protein, LINKE 99.8 1.9E-22 2.2E-27 191.3 0.0 118 918-1039 2-121 (129) 45 5X4R_A S protein; MERS-CoV, sp 99.7 2.2E-21 2.7E-26 204.5 0.0 263 14-306 12-337 (342) 46 6J11_C Spike glycoprotein, VH 99.7 2.8E-21 3.3E-26 203.4 0.0 262 14-305 12-336 (336) 47 5GYQ_A Spike glycoprotein; bat 99.7 4.2E-21 5E-26 188.9 0.0 108 332-440 2-109 (176) 48 5ZVK_A Human Coronavirus MERS 99.7 7.3E-21 8.9E-26 169.6 0.0 79 910-988 2-80 (80) 49 2BEZ_C E2 GLYCOPROTEIN; MEMBRA 99.6 8.5E-20 1E-24 162.0 0.0 77 914-990 1-77 (77) 50 6M1V_A spike protein; 2019-nCo 99.6 2.8E-19 3.4E-24 168.2 0.0 98 917-1020 1-98 (119) 51 5ZUV_A Spike glycoprotein,EK1, 99.6 1.2E-18 1.5E-23 166.1 0.0 83 914-996 2-98 (133) 52 5YL9_A Spike glycoprotein; Spi 99.5 1.1E-17 1.3E-22 151.9 0.0 74 914-987 2-89 (89) 53 1WDF_B E2 glycoprotein; MHV, c 99.2 2.7E-14 3.2E-19 131.3 0.0 62 919-980 1-62 (95) 54 1ZVA_A E2 glycoprotein; SARS c 99.0 1.7E-13 2.1E-18 121.9 0.0 58 1144-1201 15-77 (77) 55 5ZHY_D Spike glycoprotein,Spik 98.8 7.4E-12 9E-17 122.0 0.0 59 918-976 1-73 (148) 56 5XJK_A Spike protein S2; VIRAL 98.7 1.4E-11 1.7E-16 107.0 0.0 62 777-838 3-64 (65) 57 1ZV8_K E2 glycoprotein; SARS c 98.6 1.2E-10 1.4E-15 98.3 0.0 50 919-968 1-50 (50) 58 2IEQ_B Spike glycoprotein; Hum 98.5 1.3E-10 1.5E-15 109.6 0.0 84 921-1005 7-99 (109) 59 2FXP_A Spike glycoprotein; Pre 98.5 1.6E-10 2E-15 98.2 0.0 54 1158-1211 2-55 (55) 60 1WDG_B E2 glycoprotein; MHV, c 98.5 2.2E-10 2.6E-15 106.1 0.0 54 919-972 1-56 (94) 61 2BEQ_D E2 GLYCOPROTEIN; VIRAL 98.4 5.2E-10 6.3E-15 93.7 0.0 47 1166-1212 2-48 (48) 62 2BEQ_E E2 GLYCOPROTEIN; VIRAL 98.4 5.2E-10 6.3E-15 93.7 0.0 47 1166-1212 2-48 (48) 63 6LXT_F Spike protein S2; 2019- 97.7 1.4E-07 1.7E-12 91.8 0.0 45 1163-1207 87-131 (132) 64 6LXT_C 2019-nCoV S2 subunit; 2 97.7 1.4E-07 1.7E-12 91.8 0.0 45 1163-1207 87-131 (132) 65 4MOD_B HR1 of S protein, LINKE 97.5 4.8E-07 5.8E-12 88.0 0.0 64 1142-1205 40-123 (129) 66 1ZVB_A E2 glycoprotein; SARS c 97.3 1.9E-06 2.2E-11 69.0 0.0 34 958-991 1-34 (34) 67 1WDG_B E2 glycoprotein; MHV, c 97.1 5.1E-06 6.2E-11 77.9 0.0 47 1156-1202 44-94 (94) 68 6M1V_A spike protein; 2019-nCo 97.0 8.6E-06 1E-10 78.8 0.0 49 1157-1205 67-115 (119) 69 2BEQ_C E2 GLYCOPROTEIN; VIRAL 97.0 9.9E-06 1.2E-10 66.1 0.0 36 932-967 2-37 (38) 70 5ZVM_c Human Coronavirus SARS 96.7 2.6E-05 3.2E-10 65.3 0.0 41 1165-1205 4-44 (44) 71 5ZVM_b Human Coronavirus SARS 96.7 2.6E-05 3.2E-10 65.3 0.0 41 1165-1205 4-44 (44) 72 2BEZ_F E2 GLYCOPROTEIN; MEMBRA 96.4 8.7E-05 1.1E-09 61.4 0.0 42 1160-1201 1-42 (42) 73 6LVN_B 2019-nCoV S2 subunit; 2 96.2 0.00019 2.3E-09 58.1 0.0 35 1169-1203 2-36 (36) 74 1ZV8_B E2 glycoprotein; SARS c 96.2 0.00019 2.3E-09 58.1 0.0 35 1169-1203 2-36 (36) 75 6LVN_A Spike protein S2; 2019- 96.2 0.00019 2.3E-09 58.1 0.0 35 1169-1203 2-36 (36) 76 5YL9_B Spike glycoprotein; Spi 91.7 0.063 7.7E-07 48.0 0.0 41 1158-1201 4-58 (59) 77 5ZUV_A Spike glycoprotein,EK1, 89.5 0.16 2E-06 51.2 0.0 44 1161-1204 90-133 (133) 78 6MAR_D Immunoglobulin G PGT151 71.2 3 3.7E-05 42.9 0.0 29 1199-1227 154-183 (220) 79 6DCQ_D Envelope glycoprotein g 68.2 3.9 4.7E-05 45.1 0.0 49 1197-1245 146-195 (352) 80 6NIJ_B PGT145 Fab heavy chain, 68.2 3.9 4.7E-05 44.9 0.0 51 1197-1247 146-197 (345) 81 1WDF_B E2 glycoprotein; MHV, c 63.1 5.7 7E-05 39.1 0.0 56 1144-1202 40-95 (95) 82 6GY6_C XaxA, XaxB; bacterial t 58.0 8.2 9.9E-05 41.0 0.0 24 1172-1195 232-255 (424) 83 6OJ7_A Fusion glycoprotein F0; 57.5 8.5 0.0001 34.2 0.0 29 927-955 17-45 (53) 84 1G2C_W TWO HEPTAD REPEATS OF H 57.5 8.5 0.0001 34.1 0.0 29 927-955 17-45 (52) 85 6NYX_H Fusion glycoprotein F0; 57.3 8.6 0.0001 34.1 0.0 29 927-955 17-45 (53) 86 6O40_A Fusion glycoprotein F0; 57.3 8.6 0.0001 34.1 0.0 29 927-955 17-45 (53) 87 6GY8_A XaxA; bacterial toxin, 55.0 10 0.00012 39.7 0.0 22 1173-1194 233-254 (408) 88 6PWU_E Envelope glycoprotein g 52.0 12 0.00014 46.6 0.0 53 1196-1248 651-704 (858) 89 3EUH_B Chromosome partition pr 52.0 12 0.00014 44.2 0.0 126 858-988 125-264 (440) 90 3MAW_A Fusion glycoprotein F0; 50.7 13 0.00016 44.0 0.0 76 875-955 83-158 (483) 91 6EK7_A YaxA; pathogens, pore f 49.9 14 0.00017 39.3 0.0 23 1172-1194 234-256 (410) 92 1SVF_C SV5 FUSION PROTEIN; PAR 49.4 14 0.00017 34.0 0.0 29 927-955 26-54 (64) 93 1SVF_A SV5 FUSION PROTEIN; PAR 49.4 14 0.00017 34.0 0.0 29 927-955 26-54 (64) 94 2FYZ_E Fusion glycoprotein F0; 48.5 15 0.00018 33.8 0.0 29 927-955 29-57 (63) 95 2B9B_B Parainfluenza Virus 5 F 48.3 15 0.00018 43.7 0.0 76 875-955 79-154 (497) 96 5YZC_B glycoprotein F2, glycop 47.2 16 0.00019 42.7 0.0 73 878-955 1-73 (419) 97 1T98_B Chromosome partition pr 46.8 16 0.0002 41.3 0.0 104 858-966 125-236 (287) 98 1T98_A Chromosome partition pr 46.8 16 0.0002 41.3 0.0 104 858-966 125-236 (287) 99 1G5G_F FUSION PROTEIN; fusion 45.6 18 0.00021 42.9 0.0 76 875-955 83-158 (481) 100 5EVM_F Fusion glycoprotein F0; 45.4 18 0.00022 43.4 0.0 76 875-955 107-182 (529) 101 6T3F_F Fusion glycoprotein F0, 42.9 21 0.00025 42.7 0.0 76 875-955 85-160 (502) 102 3N27_B Fusion glycoprotein F0, 42.7 21 0.00025 34.6 0.0 28 927-954 18-45 (80) 103 1ZTM_C Fusion glycoprotein; fu 42.5 21 0.00026 42.4 0.0 75 876-955 90-164 (490) 104 4GIP_D Fusion glycoprotein F2, 42.0 22 0.00026 41.5 0.0 72 878-955 1-73 (409) 105 6H2E_Q AhlB; Tripartite pore-f 41.7 22 0.00027 35.5 0.0 23 1173-1195 128-150 (274) 106 5IJO_G Nuclear pore complex pr 40.4 24 0.00029 42.7 0.0 55 1133-1189 239-293 (599) 107 1WP7_A fusion protein; Nipah V 40.3 24 0.00029 34.8 0.0 28 927-954 18-45 (89) 108 1WP8_C fusion; Hendra Virus, F 39.6 25 0.00031 34.6 0.0 28 927-954 18-45 (89) 109 6R1J_J AhlB; Tripartite pore-f 39.2 26 0.00031 34.8 0.0 24 1172-1195 127-150 (272) 110 6C14_A Protocadherin-15, LHFPL 38.6 27 0.00032 35.4 0.0 26 1108-1133 82-109 (337) 111 5EJB_D Fusion glycoprotein F0; 38.0 28 0.00034 41.7 0.0 76 875-955 82-157 (501) 112 2M8R_A Syntaxin-1A; syntaxin, 36.7 30 0.00036 29.7 0.0 12 1211-1222 84-95 (109) 113 3HD7_B Vesicle-associated memb 36.7 30 0.00036 29.7 0.0 12 1211-1222 84-95 (109) 114 5C3L_B Nucleoporin Nup54, MGC8 34.3 35 0.00042 32.1 0.0 57 1131-1189 6-62 (142) 115 5G6U_A LANGERIN; CARBOHYDRATE 33.0 38 0.00046 33.5 0.0 42 1038-1090 123-164 (261) 116 3IPD_E Vesicle-associated memb 26.9 56 0.00068 28.7 0.0 9 1212-1220 68-76 (91) 117 3HD7_A Vesicle-associated memb 26.9 56 0.00068 28.7 0.0 9 1212-1220 68-76 (91) 118 6BP2_B Envelope Glycoprotein G 24.9 64 0.00078 35.3 0.0 40 925-964 122-161 (202) 119 6QD8_D Light chain, Virion spi 23.5 72 0.00087 33.9 0.0 34 931-964 61-94 (168) 120 4NJL_A S protein; six-helix-bu 22.6 76 0.00092 33.2 0.0 27 1178-1204 104-130 (131) 121 4LWS_B Uncharacterized protein 22.2 79 0.00095 26.3 0.0 32 955-986 54-85 (103) 122 2NRJ_A Hbl B protein; Enteroto 21.9 80 0.00097 32.4 0.0 15 1205-1219 194-208 (346) 123 2N2A_B Receptor tyrosine-prote 21.7 81 0.00099 26.9 0.0 23 1206-1228 1-23 (58) 124 6F5U_B Envelope glycoprotein,G 21.4 83 0.001 33.1 0.0 38 927-964 57-94 (168) 125 5F1B_B GP1, GP2, Niemann-Pick 21.4 84 0.001 31.9 0.0 37 929-965 52-88 (130) 126 6HS4_B Envelope glycoprotein,E 21.3 84 0.001 33.1 0.0 40 925-964 55-94 (168) 127 2KG7_A Uncharacterized protein 21.1 85 0.001 25.8 0.0 66 923-988 14-80 (97) 128 6W08_B NSP15 endoribnuclease; 20.9 87 0.0011 32.8 0.0 55 1139-1193 122-184 (359) 129 3OGI_C Putative ESAT-6-like pr 20.4 90 0.0011 26.8 0.0 66 921-986 11-77 (101) 130 5HJ3_L Envelope glycoprotein, 20.1 93 0.0011 31.8 0.0 35 930-964 60-94 (136) 131 6RX1_A Syncytin-1; HUMAN PLACE 20.0 93 0.0011 31.0 0.0 53 908-964 12-64 (108) No 1 >6X29_A Spike glycoprotein; Trimer, VIRAL PROTEIN; 2.7A {Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=2.9e-269 Score=2251.14 Aligned_cols=1198 Identities=99% Similarity=1.476 Sum_probs=961.9 Template_Neff=3.900 Q sp|P0DTC2|SPIK 16 VNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFAST 95 (1273) Q Consensus 16 vnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpfndgvyfast 95 (1273) |||||||||||+||.+..+|+||||..++|++.+.+|+||+|+.+++++++|||++|++....+++++.||+||+|+... T Consensus 1 ~~~~~~~~~~~~~~~~~~~g~yYpd~~~~sn~t~l~qglfp~~~s~~~~y~~~~~~gt~~~~~y~~~~~~F~dGifv~v~ 80 (1273) T 6X29_A 1 VNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFAST 80 (1273) T ss_dssp -----------CEEECCSCCCBCCSSEECCSEEEEEEEEECCTTCEEECCCCCC----------CCCCEECTTCEEEEEE T ss_pred CCcccccCCCCCcccccceeeEeeCCeeEeecccccccccCCCCCCceEEeeEEeecCCcccccCCCCcccCCeEEEEee Confidence 69999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 96 EKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPF 175 (1273) Q Consensus 96 eksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpf 175 (1273) +++|..++|+||+|.+.++++++|+++.+.+.|.+|.|++|..|++.++++.+|.+|+|++++.|..++||+|+|..|+| T Consensus 81 ~~~n~~p~~~fGstf~n~s~tvvI~P~~~~~~it~C~~~vC~~p~~~~~~~~g~~~~~~~~~~~~~~~~nc~f~~~~~nf 160 (1273) T 6X29_A 81 EKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPF 160 (1273) T ss_dssp ESSCCEEEEEEESSCSSSSCCCEEEECSSCEEEECCCCCCCSSCCEEC---------------------CCCCEEEC--- T ss_pred ecccCcceEeEEeccCCCcEEEEEeCCCcceEEEEEEEEecCCCeeEEEeecCCceeeeeehhhhccCCCceEEEecCCc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 176 LMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSS 255 (1273) Q Consensus 176 lmdlegkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdss 255 (1273) .||.+.++|+|...++|+|++.||+|.+|..+++++..+.+|+|+..+.|..++|+|+||+|+|.++.+.|++.+|++.+ T Consensus 161 t~d~~~~~~~~~~~~~~~F~~~dG~f~iY~~~~~~~~~~~~~~~~~~~~yy~~~p~g~n~~~~~~~~~~~~~~~~~~~~~ 240 (1273) T 6X29_A 161 LMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSS 240 (1273) T ss_dssp ----------CCEEEEEEEEEETTEEEEEEEEEECCCSSSCCSSCCCBEEEEEEECCCCCSEEEEEEEEC---------- T ss_pred eeccccCccceeeeEeEEEEecCCeEEEEEeCCCCcccccCCccccccchhhcCCCCCccccceeEEEeeeecCCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999889 Q sp|P0DTC2|SPIK 256 SGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNL 335 (1273) Q Consensus 256 sgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnl 335 (1273) ++|+.+.++|||+||+||+|||+|++||.||+||||+.||++|.||..+||++++|+|++|+||+||...++|+++++.. T Consensus 241 ~~~~~~~~~~yV~~L~~r~yLl~fd~nG~It~AvDCa~~~~sEL~Cst~SF~p~tGVY~lS~yraqP~~~V~~~~~~~~~ 320 (1273) T 6X29_A 241 SGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNL 320 (1273) T ss_dssp -------CCEEECCCEEEEEEEEECTTSCEEEECCTTSCHHHHHHHHHTCSSCCSEEEEEEEEECCCCCCCEECCCCCCB T ss_pred cccceeeeEEEEEeccceeEEEeecCCCeEeEEEecccCcchhceeEecceecCCcEEeccCeEEEeceEEEEcCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 336 CPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQT 415 (1273) Q Consensus 336 cpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqt 415 (1273) |+|.+++++.++.++|.|.|++++||..|+++|++..++++|+||||+|.||.++||..|++|.|.|..++.++++||++ T Consensus 321 C~~~~~~~~~~~Psp~~w~R~~fsNCnfn~s~Lls~~~~~~f~C~~ispskL~~mCfssvtiD~F~ip~~~~~~l~~g~~ 400 (1273) T 6X29_A 321 CPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVCPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQT 400 (1273) T ss_dssp CCCHHHHTCSSCCCGGGCEEEEECSSBCCHHHHHHCSCCSEEEESSSCGGGGTTCCCSEEEEEEEEECGGGGTTCSTTCC T ss_pred CChhHHhcCCCCCCcceeEEEEEecCCCcHHHHhhccccceeEEeCCCHHHhcccccCeeEEEEEEecccceeecCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 416 GKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSY 495 (1273) Q Consensus 416 gkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsy 495 (1273) |.|++||||+|+||+||+++|+.++++..+.++|||++|.+++++++|||||+++|+||.+.++|+...|.+|++|+..+ T Consensus 401 g~i~~yNYkl~~~~~~C~l~~~~~~~~~~~t~~y~~~~~~~~~~~~~~~~~~~~~~~y~~~~~~C~~~~~~~C~~pl~~~ 480 (1273) T 6X29_A 401 GKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSY 480 (1273) T ss_dssp STTTTTTCCCCTTCCEEEEEEECTTTTCC--CBCCCEEC-------CTTCCCC--------------------CCSCEEC T ss_pred cHHHhcCcCCCCCCCCeEEEEEeCCcccCCcccHHHHHHhcccCCCCcccCCCchhhhcCCCCCCCCCCcccceeccccc Confidence 99999999999999999999999999998999999999999999999999999999999999999976799999999999 Q sp|P0DTC2|SPIK 496 GFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDA 575 (1273) Q Consensus 496 gfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttda 575 (1273) ++....|++++.+++++++++....|++|||.+..++++.++||++|..|.||+||++++|..+..+|.||.++.|+..+ T Consensus 481 ~~~~~~g~~~~c~~lv~IT~~~t~~~~~Vc~~~~~snI~LnvCVdYNIYGiTGqGVItntn~t~~~~q~~gl~~~g~s~g 560 (1273) T 6X29_A 481 GFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDA 560 (1273) T ss_dssp CBCTTC-CTTSCEEEEEEEEECCSSCCCCCCSCCCCCCCCSSEECCEETTEECCEEEEECCCCCCTTCCEEECTTSCEEE T ss_pred ceecCCcccceeeEEEEEEEecCCCCCcccCCcCCceeEeceEEeeEeCCceeEEEEEecCCCCccchhcceecCCCcce Confidence 88888999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 576 VRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEH 655 (1273) Q Consensus 576 vrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaeh 655 (1273) +|++.++++..|+||..+.++|+..|+|+++|+|+||..+||++++.++++.+++|.|++++++++.||||+||++||.+ T Consensus 561 FKn~ttG~~YsV~PC~~~~QsVVy~g~~~s~q~AgL~tSinCt~v~~~~~s~~~t~~fy~~s~~~~~~~T~~gcv~na~~ 640 (1273) T 6X29_A 561 VRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEH 640 (1273) T ss_dssp EECSSSCCEEEEECCCEEEEEEEECCTTTCSCCEEEEETCCTTCC--------------------CEEECSSEEEESCEE T ss_pred EECCCCCCEEEEEeCcccceEEEcCCCCCcceEEEEEeccCCCCCcceeeccccCCeeEEEeCCCCceeeceeEeeccee Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 656 VNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTS 735 (1273) Q Consensus 656 vnnsyecdipigagicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtkts 735 (1273) .++..+|+.|+|.|||+.+.+...+++..+.+....+..|+|.+..+..++.+...|.||+||||+|++|.++++|.|.+ T Consensus 641 ~t~~~~C~~Pvg~giC~d~~~~~~~~~s~~~~~~~~l~~~~~p~~~~~~~~~~~~~i~IP~nFtlsvt~EyiQt~~~kVs 720 (1273) T 6X29_A 641 VNNSYECDIPIGAGICASYQTQTNSPGSASSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTS 720 (1273) T ss_dssp CSSCCCCSEEEETTEEEEEEC------------CCEEEEEECCCSCEEECCCCTTEEEEEEEEEEEEEEEEEECCCCCEE T ss_pred cCCCCcCCCCceEEEeecCCccCCCCCccccccceeEEeeeccCCccccccccceEEEccCCeEEEEEEEEeeecCCceE Confidence 99999999999999999999843333323345667888999988887888899999999999999999999999999999 Q sp|P0DTC2|SPIK 736 VDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKR 815 (1273) Q Consensus 736 vdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskr 815 (1273) |||.+|+|||+.+|.+||.|||+||..+|+||.|.+..+|.+..+++..+++.++++.+.+|+||||+.+||.+++|++| T Consensus 721 IDC~~YVC~~~~rC~~LL~QYgsfC~~I~~aL~~~a~led~~~~~~~s~~~~~~~~~~~~~~~~fN~s~llp~~~~~~~R 800 (1273) T 6X29_A 721 VDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKR 800 (1273) T ss_dssp ECHHHHHSTTCHHHHHHHGGGCTTHHHHHHHHHHHHHHHHHHHHHHHTTSSSEEECCSSCCSTTCCCTTTSBCTTSSSCC T ss_pred EecchhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhcHHHHHHHHHhhHHhcCCCcccCCCccccccCCCCCCCCCc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 816 SFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQ 895 (1273) Q Consensus 816 sfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalq 895 (1273) |+||||||+||+.+|.|+.+.|.+|.++..+|||+|||.|||+.||||++++||++.||++|++|....|||||+++|.. T Consensus 801 SaIEDLLF~KV~t~glG~~~~Yk~Ct~g~~i~DL~CAQyyNGimVLPpv~d~~~~amYTasL~g~m~~gg~T~G~tsaaa 880 (1273) T 6X29_A 801 SFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQ 880 (1273) T ss_dssp BHHHHHHSSSCC--------------------------CCSSEEECCCSSCHHHHHHHHHHHHHHHHHHTTHHHHSSCCC T ss_pred cHHHHHhcCceEeCCCChhHhhHHccCCccHHHHhcccccCcEEEeCCCCCHHHHHHHHHHHHHHHHhcccccCcchhcc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 896 IPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISS 975 (1273) Q Consensus 896 ipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaiss 975 (1273) |||||||.||+||+|+||+||.||||+|||.||.||+.||+.++.|++||.|+|||||++++||++|++||+.||||||| T Consensus 881 iPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~i~~g~~tts~AL~kiQ~VVN~~~~aL~~L~~QL~nnFgAISS 960 (1273) T 6X29_A 881 IPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISS 960 (1273) T ss_dssp CCHHHHHHHHHHTTTCCTHHHHTTHHHHHHHHHHHHHHHHHHHSSCGGGGHHHHHHHHHHHHHHHHHGGGGGCCTTSSCS T ss_pred chhHHHHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 976 VLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQS 1055 (1273) Q Consensus 976 vlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqs 1055 (1273) .++||++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..||+|||..||+|.+|||.|.|++|+||. T Consensus 961 SI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtQ~L~~~~evr~sr~LA~qKINECVKsQS~R~gFCGnG~Hi~S~~q~ 1040 (1273) T 6X29_A 961 VLNDILSRLCPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQS 1040 (1273) T ss_dssp CHHHHTTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTSSCCCSTTSSSSSEEEECCEEE T ss_pred HHHHHHHhhchhHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccCcccCcCCCCeeEEecccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1056 APHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNN 1135 (1273) Q Consensus 1056 aphgvvflhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnn 1135 (1273) ||+|++|+|++|+|.+.++.+++|.+|+++++..|++|+|+.|+++|++|.|++|||..||.+|..+...|||....+|+ T Consensus 1041 AP~Gi~F~H~~~~Pt~~~~v~a~~GlC~~~~~~~~~~g~~~~~~~~~~~T~r~~y~P~~~t~~d~v~i~sC~V~y~~vn~ 1120 (1273) T 6X29_A 1041 APHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNN 1120 (1273) T ss_dssp ETTEEEEEEEEEEEEEEEEEECBSCEESSSCEEEESSSEEEESSSSEEEECSSSCCCBCCBTTTEEECSCTTTSTTCEEC T ss_pred CCCeEEEEEEEecccceEEEEEeceEeeCCceeeecceEEEEcCCEEEEcccccccCccCCCCceEEeccceeEEEEecc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1136 TVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWP 1213 (1273) Q Consensus 1136 tvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyikwp 1213 (1273) ++.+|++|++..|+|||+|||||||+|+.++++++.+|++++|++.||++|+|+.|+||+++|||++|++||+|-+++ T Consensus 1121 t~~~~~~pd~~df~~el~~~~~N~t~p~~~~~~~~~~N~T~LNLt~EI~~Lq~~I~~LN~slIDLe~Ln~~e~y~~~~ 1198 (1273) T 6X29_A 1121 TVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQGSGYI 1198 (1273) T ss_dssp CCBCSHHHHHHC------------------------------------------------------------------ T ss_pred cccCCCCCCCCCHHHHHHHHccCCCCCCCCCCccccccccccchHHHHHHHHHHHHHHHHhcccHHHhcceeeeccCC Confidence 999999999999999999999999999999999999999999999999999999999999999999999999998764 No 2 >6CS2_B Spike glycoprotein,Envelope glycoprotein, Angiotensin-converting enzyme; membrane fusion, glycoprotein, receptor binding; HET: BMA, MAN, NAG;{Human SARS coronavirus} Probab=100.00 E-value=3.2e-221 Score=1857.50 Aligned_cols=1161 Identities=77% Similarity=1.263 Sum_probs=1101.0 Template_Neff=4.100 Q sp|P0DTC2|SPIK 31 SFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTL 110 (1273) Q Consensus 31 sftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgttl 110 (1273) +-.+|+||||..++++...-+|++|.++-++++-+|+. -.-+.+++.||+||+++...+++|.-++|+||+|. T Consensus 22 ~~~~g~yYPd~~~~sN~t~L~qglfp~~gs~~~~~~~~-------~~~y~~~~~~F~dGifv~v~~~~n~~~a~~fGsTF 94 (1215) T 6CS2_B 22 SSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHTI-------NHTFGNPVIPFKDGIYFAATEKSNVVRGWVFGSTM 94 (1215) T ss_pred cccceeEecCCeeeccceeeeeCccCCCCCCCccCCcc-------hhhcCCCccccCCcEEEEeeEecCCCCceeeeecc Confidence 45689999999999999999999999999999987776 34577889999999999999999998899999999 Q sp|P0DTC2|SPIK 111 DSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLR 190 (1273) Q Consensus 111 dsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknlr 190 (1273) +..+++++|+++-+...|.+|.|..|..|...+++.-.| -.+++.|..+.||+|.|.|+.|-+|...+-.+....+ T Consensus 95 ~N~s~tvVI~P~~~~~~it~C~~~vC~~p~~~~~p~~gn----~~~~~~~~~~~nc~f~~~~~nfT~d~~~~~~~~~~r~ 170 (1215) T 6CS2_B 95 NNKSQSVIIINNSTNVVIRACNFELCDNPFFAVSKPMGT----QTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHLR 170 (1215) T ss_pred cCCceEEEEcCCCCcceeeEeEEEeCCCCceeEcCCCCC----cccccceeecCCceEEEcccccccccccceeeeeEEE Confidence 999999999999999999999999999999988874443 4678889999999999999999999888888888899 Q sp|P0DTC2|SPIK 191 EFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 191 efvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) +|+|++.||+|-+|-.+.+.+..+.+|.|...|.|..-+|..++|+.|..++ -.|| ++ .+.|+...++|||.+| T Consensus 171 ~f~F~~~~G~fy~Y~a~~~~~~f~~~~~~~~~l~yy~vip~~~~~~~~~~~~-~~~~--~~---~~~~~~~~~~~yv~~L 244 (1215) T 6CS2_B 171 EFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNTLKPIFKLPLGINITNFRAIL-TAFS--PA---QDIWGTSAAAYFVGYL 244 (1215) T ss_pred EEEEEecCCeEEEEeecCCCcccccCCCCcccceeeEeeceecccccceEEe-eecC--CC---CCcccccceEEEEeec Confidence 9999999999999988877777899999999999999999999999998872 2233 22 5677888999999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASV 350 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasv 350 (1273) .+|+++|.|..||+|+|++||+-+|.+|-+|.-.+|....|.|..++++++|.-...|.......|+|.+++++.++.++ T Consensus 245 ~~~~~lLayf~NGti~dvIdC~~sp~~~LaCqy~T~nfsdGvYp~s~~~vk~~fiVyr~~~~~~~C~~~~~~~~~~~Psp 324 (1215) T 6CS2_B 245 KPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNITNLCPFGEVFNATKFPSV 324 (1215) T ss_pred eeceeehHHhcCCeEEEEEECCCCcccceeceeceeccCCCeeeccceEeeceEEEEECCCCCCCCCHHHHhhCCCCCCc Confidence 99999999999999999999999999999999999999999999999999999999999988899999999999999999 Q sp|P0DTC2|SPIK 351 YAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT 430 (1273) Q Consensus 351 yawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddft 430 (1273) |.|.|+.++||..|+++|++..++++|+||||||.||.+.||..|++|.|.|..+..++++||++|.|++||||+|+||+ T Consensus 325 ~~w~R~~fsnCnfn~s~Lls~~~~~~f~C~gIspskLa~mCfsSvtiD~F~ip~s~~~~l~~g~~g~i~~~NYkl~~~~~ 404 (1215) T 6CS2_B 325 YAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFM 404 (1215) T ss_pred cceeEeEEecCCCCHHHHHhcceeeeeEeeCCCHHHHcccccCeeeEEEeeccccchhhcCCCCCchHHhcccCCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 431 GCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRV 510 (1273) Q Consensus 431 gcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrv 510 (1273) ||+++|+-.+++..+..++|+.++-.|+..++|+++|.+.--+.-...+|. ..|-.|..++..|.+...-|+|++++++ T Consensus 405 ~C~l~~~~~~~~vn~t~~~n~~~~~~r~~~~~~~~~d~~~CPf~~~~s~C~-~~~~~~~~~i~~~~~~~~~g~~~~~~g~ 483 (1215) T 6CS2_B 405 GCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCT-PPALNCYWPLNDYGFYTTTGIGYQPYRV 483 (1215) T ss_pred ceEEEEEcCccceeccCCCCcccccccccceeecCCCCCCCCCCCCCCCCC-CCCCCCCcccccccceeeccccceeeEE Confidence 999999988888776667777766666666889999888744444467884 3666777788888765567999999999 Q sp|P0DTC2|SPIK 511 VVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPC 590 (1273) Q Consensus 511 vvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpc 590 (1273) ++++++....|++|||+|..+.++.+.||++|+.|.||+||++|+|..+..+|.|+.|..+-..++||+.|+++..|+|| T Consensus 484 lvis~k~~~~p~tVCg~~~~T~l~ldvCV~YnIYGiTGtGVi~~sn~t~~sgqsf~~ds~GfL~gfKn~ttG~iYsI~PC 563 (1215) T 6CS2_B 484 VVLSFELLNAPATVCGPKLSTDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEILDISPC 563 (1215) T ss_pred EEEEEEEcCCCCcccCCcCccceeeceeEeEEeCCceeeEEEEecCcEecCCeeeEEeCCcceeEEEeCCCCCEEEEeeC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 591 SFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGI 670 (1273) Q Consensus 591 sfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsyecdipigagi 670 (1273) .++.|||+.+|.++|+..|+||..++|+++....+..+.+|.|+.++++.+.|||-+||++||++.+...+|++|+|.|+ T Consensus 564 ~s~~VSVVy~g~~sS~~~alLf~~v~C~~v~~~~~~~~~~p~~~~~s~~~~~fdT~~GCv~na~n~~~v~~C~lplG~Gl 643 (1215) T 6CS2_B 564 AFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWRIYSTGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGI 643 (1215) T ss_pred eecceEEEEcCCccCCCcceeccccccccccccccceeecCceEEeeCCCCCcccccceeecccCCCcccccCcccccee Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 671 CASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECS 750 (1273) Q Consensus 671 casyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecs 750 (1273) |+.+.+ .++.|+....++..|+++++....++.+...|.||+||||+|++|-++++|.|.+|||.+|+||++.+|. T Consensus 644 C~d~~~----~~~~~~~~~~~~~~y~~p~~~~s~~~~~~~~i~IP~nft~~v~~Eyiq~~~~kv~idC~~YVC~~~~~C~ 719 (1215) T 6CS2_B 644 CASYHT----VSLLRSTSQKSIVAYTMSLGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECA 719 (1215) T ss_pred ecCCCc----eeeccCCCceeeeeeecCCCCCCCCCceeeEEEccCCeEEEEEEEEeeecCCCeEEechhhccCCCHHHH Confidence 999988 3333335566778999998765578888999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 751 NLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLAD 830 (1273) Q Consensus 751 nlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedllfnkvtlad 830 (1273) +||.|||+||..+|+||.+.+..+|.+..+++...++-++.|-+..||||||+.+||.++++++||+||||||+||..+| T Consensus 720 ~lL~qYgs~C~~I~~al~~~~~l~d~~~~~~~~~~~~~~~~~~~~~~~~~n~s~~l~~~~~~~~RS~iEDLLF~KV~t~g 799 (1215) T 6CS2_B 720 NLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLAD 799 (1215) T ss_pred HHHHHHHHHHHHHHHHHHHHHhHHhHHHHHHHHhcccCCCCCcccccCCccchhcCCCCCCCCCccHHHHHHcCeeeeCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 831 AGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIG 910 (1273) Q Consensus 831 agfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngig 910 (1273) .|+.+.|.+|.+...+|||+|||.+||+.||||++++||++.||++|++|....|||||+|+|..|||||||.||+||+| T Consensus 800 ~g~~~~Y~~C~~g~~i~DL~CaQ~ynGi~VLP~v~~~~~~a~YT~sl~g~ma~gg~T~g~~sa~aiPFa~~vq~RlN~v~ 879 (1215) T 6CS2_B 800 AGFMKQYGECLGDINARDLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIG 879 (1215) T ss_pred CCchhhHhhccCCccHHHHhcccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhccccccccccccccHHHHHHHHhchhh Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 911 VTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAE 990 (1273) Q Consensus 911 vtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveae 990 (1273) +||+||.||||+|||.||.||+.||+.++.+++||.|+||||||+++||++|++||+.|||||||.++||++|||++||+ T Consensus 880 l~~~vL~~NQk~iA~sFN~A~~~i~~g~~t~~~Al~kiQ~VVN~~~~aL~~L~~qL~~nFgAISssi~dIy~RLd~leAd 959 (1215) T 6CS2_B 880 VTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAE 959 (1215) T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 991 VQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPA 1070 (1273) Q Consensus 991 vqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpa 1070 (1273) +||||||+|||.+|++||+|+|+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+||.||+|++|+|.+|+|. T Consensus 960 aQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~lA~qKinECVksQS~R~gFCGnG~Hi~S~~q~AP~Gi~F~H~~~~Pt 1039 (1215) T 6CS2_B 960 VQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPS 1039 (1215) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccCcCCCCCCeeeEeecccCCCeEEEEEEeeccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1071 QEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKE 1150 (1273) Q Consensus 1071 qeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydplqpeldsfke 1150 (1273) +.++.+++|.+|+++++..|++|+|+.|++.|++|.|++|||..||.+|...-..|||....+|+++.+|++|++..|+| T Consensus 1040 ~~~~v~a~~GlC~~~~~~~~~~g~f~~~~~~~~~T~r~~y~P~~~t~~d~v~i~sC~V~y~nvn~~~~~~~~p~~~df~~ 1119 (1215) T 6CS2_B 1040 QERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKE 1119 (1215) T ss_pred ceeEEEEEceeeeCCCceeecceEEEEcCcEEEEeccccccCCCCChhceEEeecCceeEEeecCCCCCCCCCCCCCHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1151 ELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWP 1213 (1273) Q Consensus 1151 eldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyikwp 1213 (1273) ||++|+||||+|+.+++++..+|++++|++.||++|+|+.|+||+++|||++|++||+|-+|+ T Consensus 1120 el~~~~~N~t~p~~~~~~~~~~N~t~LnLt~EI~~L~~~i~~LN~s~IDLe~L~~~e~ya~~~ 1182 (1215) T 6CS2_B 1120 ELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQGSGYI 1182 (1215) T ss_pred HHHHHhcCCCCCCCCCCChhhccccccchHHHHHHHHHHHHHHHhcCcCHHHhcceeHhhcCC Confidence 999999999999999999999999999999999999999999999999999999999998875 No 3 >6Q04_B Spike glycoprotein; Coronavirus, spike glycoprotein, MERS-CoV, membrane; HET: MAN, SIA, NAG, FOL, BMA; 2.5A {Human betacoronavirus 2c EMC/2012} Probab=100.00 E-value=1.8e-204 Score=1723.92 Aligned_cols=1150 Identities=31% Similarity=0.496 Sum_probs=897.1 Template_Neff=3.700 Q sp|P0DTC2|SPIK 31 SFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRFDNPVLPFNDGVYFASTEKSNII 101 (1273) Q Consensus 31 sftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krfdnpvlpfndgvyfasteksnii 101 (1273) +-.+|+||||..++++..+-.|++|.+.-++.+-.- ++|++. + -.++.+..||+||+++...+.+|-- T Consensus 65 s~~~G~yYPd~rvysN~TlL~qglfP~~gs~~~~y~---~~~t~~~s~~~~~~~~~~y~~~~~~F~dGifvkv~~~~n~t 141 (1359) T 6Q04_B 65 SKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANYSQDVKQFANGFVVRIGAAANST 141 (1359) T ss_dssp GGTTTCBCCTTCEECSEEEEEEEEECCTTCCCEEEC---CEECCEETTEECSEEECSCTTCCEECTTCEEEEESTTTTSE T ss_pred ccCceeEeeCCeeEeeeeeeeeceecCCCCcceEEE---EEecCCCCCCCcceeeeccCCChhhccCeEEEEEeeeecCC Confidence 346899999999999999999999999988876542 333332 1 3567789999999999888766643 Q sp|P0DTC2|SPIK 102 R-----------------GWIFGTTLDSKT---Q------SLLIVNNATNVVI-------KVCEFQFCNDPFLGVYYHKN 148 (1273) Q Consensus 102 r-----------------gwifgttldskt---q------sllivnnatnvvi-------kvcefqfcndpflgvyyhkn 148 (1273) . .++||+|.+... + +++|+++-.+.++ ...+..-|..|..-+++.-+ T Consensus 142 g~~~~~~~~~~~~~~~ypa~~fGsTF~Nts~~~~~~~~~~tlVI~P~~~g~~~~~~~c~~~prtit~C~~p~~~~~p~~~ 221 (1359) T 6Q04_B 142 GTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYCILEPRSGNHCPAGNSYTSFATY 221 (1359) T ss_dssp EEETTEEEEEEEEECCCCCEEEESCEEECTTSCEEEECSEEEEEEEETTTTEEEEEEEEEEECCSBTSTTSSSCCCCCEE T ss_pred CCeeeCCccccchhhhccceEeeccccCCCCCccccccceEEEEecCCCCchheeeeecccccccCcCCCCCeEeeeeec Confidence 2 256999998666 5 8899988887543 32333345555555554222 Q sp|P0DTC2|SPIK 149 N---KSWMES---------EFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNID-GYFKIYSKHTPINL--- 212 (1273) Q Consensus 149 n---kswmes---------efrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknid-gyfkiyskhtpinl--- 212 (1273) . .+|..+ +++.|....+|+|.|. +.|-+|... ..|- |.|+..| |.|-+|.-++..+. T Consensus 222 ~~~~~~~~~~~~~~n~~~~~~~~~~~~~~~~~~~~-~nfT~d~~~--~wf~----~~F~~~~~G~f~~Y~~d~~~~~~f~ 294 (1359) T 6Q04_B 222 HTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYT-YNITEDEIL--EWFG----ITQTAQGVHLFSSRYVDLYGGNMFQ 294 (1359) T ss_dssp ECHHHHBCSSCBCTTHHHHHHHHHEEEEEEEEEEE-EECCCCCCC--EEEE----EEEETTEEEEEESTTTCTTTCCBEE T ss_pred CCCCccCCCCcccccccccchhHhcccCCceEEEe-eecCcchhh--heee----EEeeecCceeEEEEEEecCCCccee Confidence 1 245333 6778889999999875 344333211 1121 9999999 99999876654432 Q sp|P0DTC2|SPIK 213 VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCA 292 (1273) Q Consensus 213 vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdca 292 (1273) ..-+| |+..+.+.. .+-|+..++ .+.+. ..++|||++|.+|+|||+|++||.|++||||+ T Consensus 295 f~~~~-~~~~~~yy~---------------v~p~~~~~~---~~~~~-~~~~~yv~~L~~~~~Ll~fd~nG~I~~avDC~ 354 (1359) T 6Q04_B 295 FATLP-VYDTIKYYS---------------IIPHSIRSI---QSDRK-AWAAFYVYKLQPLTFLLDFSVDGYIRRAIDCG 354 (1359) T ss_dssp EEEEC-CCSCCCEEE---------------ECCEEECCC---GGGCC-EECCEEEEECEEEEEEEEECTTSCEEEEEETT T ss_pred ccccc-ceeccceee---------------eeeeeecCC---ccccc-eeEEEEEEEccceeEEEeecCCCeEEEEEecC Confidence 12222 444444443 233444444 34455 77899999999999999999999999999999 Q sp|P0DTC2|SPIK 293 LDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSA 372 (1273) Q Consensus 293 ldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsa 372 (1273) -|+++|-||..+||.+++|+|++|+||+||....+|.++. ..|+|.++++ .++.++|.|.|+.++||..|+|+|++.. T Consensus 355 ~~~~sEL~C~~~sf~~~tGVY~~S~y~aqp~~~v~~~~~~-~~C~~~~~~~-~~~P~p~~w~R~~f~nCnfN~s~Lls~~ 432 (1359) T 6Q04_B 355 FNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEG-VECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLF 432 (1359) T ss_dssp SCHHHHHHHHTTSSCCCSEEEEEEEECCCCSCEEEECCCS-CBCCCGGGGS-BCCCBGGGCEEEEECSEEECHHHHHTTS T ss_pred CCccchheeEeceecCCCCeeecCCEEEEeeeEEEEecCC-CCCCchHHhc-CCCCCcceeEEeEEecCCCcHHHHHhhc Confidence 9999999999999999999999999999999999999999 9999999999 8899999999999999999999999999 Q sp|P0DTC2|SPIK 373 SFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKV--GGNYN 450 (1273) Q Consensus 373 sfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskv--ggnyn 450 (1273) .+++|+||||+|.||.+.||..|++|.|.|..+..++++||++|-|++||||+|+||+||+++|+-...+..+ -.+|+ T Consensus 433 ~~~sF~C~gIspskLa~mCfsSvtiD~Faip~~~k~~Lq~G~~G~i~~yNYKld~~~~gC~l~y~~pa~~vn~t~p~~y~ 512 (1359) T 6Q04_B 433 SVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYS 512 (1359) T ss_dssp EEEEEEEESSCHHHHTTCCBSEEEEEEEECCGGGGGGGSTTBCSHCCCCCCCCCSSSCEEEEEEECCTTCTTBCCCSEEE T ss_pred eeeeeeecCCCHHHHcccccceeeEEEEecCccccceecCCCCChhhhccccCCCCCCccEEEEEcCccccccCCCccce Confidence 9999999999999999999999999999999999999999999999999999999999999999955533322 44555 Q sp|P0DTC2|SPIK 451 YLYRLFRKSNLKPFERDISTEI---YQAGSTPCNGV-EGFNCYFPLQSY-----------GFQP----TNGVGYQPYRVV 511 (1273) Q Consensus 451 ylyrlfrksnlkpferdistei---yqagstpcngv-egfncyfplqsy-----------gfqp----tngvgyqpyrvv 511 (1273) |+.|-+++.. ++. ++. ..+ .+-|+-. ...+|+.|...+ |..| ..++++|++.++ T Consensus 513 yi~~~~~~~~-----~~~-~~~~~~~~~-~~~cpc~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~ 585 (1359) T 6Q04_B 513 YINKCSRLLS-----DDR-TEVPQLVNA-NQYSPCVSIVPSTVWEDGDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGF 585 (1359) T ss_dssp EEEEEEEECT-----TSS-CEEECCCCT-TSCCGGGGTSCSSCSSTTCEEEEECCGGGTSSEEEEEEEEEECCSSCEEEE T ss_pred eeeeeeccCC-----CCC-Ccchhhccc-cccCCCCccCCccccCCCCccccccccccCCchhcccccccccccceeEEE Confidence 5555555333 222 222 111 1112100 112455543322 2333 458999999999 Q sp|P0DTC2|SPIK 512 VLSFELLHAPATVCGP-----KKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILD 586 (1273) Q Consensus 512 vlsfellhapatvcgp-----kkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleild 586 (1273) |++++..+.++|||++ |.+|.++.++||++++.|+||+||++|+++.+.++|+|..|-.+-..++|| +++++.+ T Consensus 586 Vis~k~~~~s~tVCp~~~d~~~~~T~~~lg~CVnY~LYGiTGtGVf~~s~~~~~s~Q~f~yDs~Gnl~gf~d-~tn~~Y~ 664 (1359) T 6Q04_B 586 GITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQRFVYDAYQNLVGYYS-DDGNYYC 664 (1359) T ss_dssp EEEEESSSSCCCEEECCCCCTTSCSGGGTTSEEEEEETTEEEEEEEEECCCCSCGGGCEEECTTSCEEEEEC-TTSCEEE T ss_pred EEEeEcCCCcCccCCCccccCCCCcchhcCceeEEEecceeeeeEEEecCceeecceeeEEeCCCCEEEEEe-CCCCEEE Confidence 9999999999999998 667999999999999999999999999999999999999999999999999 8999999 Q sp|P0DTC2|SPIK 587 ITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRV--YSTGSNVFQTRAGCLIGAEHVNN-SYECD 663 (1273) Q Consensus 587 itpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrv--ystgsnvfqtragcligaehvnn-syecd 663 (1273) |.||..|+|||+++++ ++.+|+||++++|.+|+...+..+.+|.||+ +++..+.|||-+||++||++.+. .+||| T Consensus 665 I~PC~sg~VSV~y~~~--s~e~AlLf~~l~C~~v~~~~~~~~~~~~~~l~~~~~~~~~fdT~~GCVvnA~n~t~~V~~C~ 742 (1359) T 6Q04_B 665 LRACVSVPVSVIYDKE--TKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGPLQTPVGCVLGLVNSSLFVEDCK 742 (1359) T ss_dssp EECCCCEEEEEEEETT--TTEEEEEEETCCGGGC---------------------CCCEEETTEEEESEEEEEEEESSCS T ss_pred EeeceEEeeeEEEcCC--CCCeEEEEccccccHhhcceeeccCCCccccccccCCCCCCCCccceeeeceecCCceeeCC Confidence 9999999999999998 8999999999999999999999999999998 77788999999999999999988 89999 Q sp|P0DTC2|SPIK 664 IPIGAGICASYQTQTNSPR-RARSVAS-QSII--AYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCT 739 (1273) Q Consensus 664 ipigagicasyqtqtnspr-rarsvas-qsii--aytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdct 739 (1273) +|+|.|+|+.|.+...+.| +.|++.. ..+. +|+|.+-. .++.+++..|.||+||||+|++|-++++|.|.+|||. T Consensus 743 LplG~glC~~y~~~s~~~~r~~~~~~~~~~l~~~~y~~P~~~-~~~~~~~~~i~IP~nFt~~v~~EyiQ~~~~kv~iDC~ 821 (1359) T 6Q04_B 743 LPLGQSLCALPDTPSTLTPASVGSVPGEMRLASIAFNHPIQV-DQLNSSYFKLSIPTNFSFGVTQEYIQTTIQKVTVDCK 821 (1359) T ss_dssp SEEETTEEEECCCC------------CCEEEEEECCCCCEEC-CCCSSSCEEEEECSEEEEEEEEEEEECCCCEEEECHH T ss_pred CCCCceeecCCCCCCCCCCcccCCCCCceEEEEEeecCCeee-cccCCCCeeEEcccceEEEEEEEEEeecCCceEEech Confidence 9999999999998774433 3343333 3344 77787766 7888999999999999999999999999999999999 Q sp|P0DTC2|SPIK 740 MYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF-GGFNFSQILPDPS---KPSKR 815 (1273) Q Consensus 740 myicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdf-ggfnfsqilpdps---kpskr 815 (1273) +|+||++.+|.+||.|||+||..+|+||.|.+.++|.+..+++..+++-++.+-+..| |+|||+.+||... ++++| T Consensus 822 ~YVC~~~~~C~~lL~qYgs~C~~I~~aL~~~~~~~d~~~~~~~~~~~~~~~~~~~~~f~~~~N~s~ll~~~~~~~~~~~R 901 (1359) T 6Q04_B 822 QYVCNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLFASVKSSQSSPIIPGFGGDFNLTLLEPVSISTGSRSAR 901 (1359) T ss_dssp HHHHTTCHHHHHHHGGGCSHHHHHHHHHHHHHHHHHHHHHHHHHHHCCSEECCCCTTTTTTSCCTTTSBC--------CC T ss_pred hhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHhhccHHHHHHHHhccccccCCCcCCCCCCcccceeccCCCCCCCccce Confidence 9999999999999999999999999999999999999999999999999998888887 5799999999875 34689 Q sp|P0DTC2|SPIK 816 SFIEDLLFNKVTLADAGFIKQYGDCLGDI--AARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAA 893 (1273) Q Consensus 816 sfiedllfnkvtladagfikqygdclgdi--aardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaa 893 (1273) |+||||||+||.+.+.||...|+.|.... ..+||+|||.+||+.||||..++||.++|+.+++.+....||++|..++ T Consensus 902 S~ieDLLF~Kv~~~~~G~~~~y~~c~~g~~~~i~Dl~caq~~NGi~VLP~v~~~~le~~Yt~SdvG~l~~~r~e~G~tsa 981 (1359) T 6Q04_B 902 SAIEDLLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSSF 981 (1359) T ss_dssp BHHHHHHHHTSCCCCCCTTTHHHHHHHTCCSSTTCTTTTHHHHTEEEECCSSCHHHHHHHHHHHHTTHHHHSSSSSSSCE T ss_pred eHHHHHhcceeeeCCCCcccChhhhcccCCccHHHHhheeEeCCEeecCCccCHHHHHHHHHHHHHhhhcccccccCCcc Confidence 99999999999999999999999999555 8999999999999999999999999999999999988888999999999 Q sp|P0DTC2|SPIK 894 LQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAI 973 (1273) Q Consensus 894 lqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgai 973 (1273) ..|||++++.+|+|+++++|++|.+|||.|||.||.|||.||+.+.++++||.|+|++||+++++|++|..||+.||||| T Consensus 982 aaIpfs~~Vy~RLN~l~~~~~vL~~nq~~Ia~sFN~AI~~iq~Gf~t~~~Al~kIq~vVN~~~~aLs~L~~qLn~nFgAI 1061 (1359) T 6Q04_B 982 AAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFQKVQDAVNNNAQALSKLASELSNTFGAI 1061 (1359) T ss_dssp EECCHHHHHHHHHHTTTCCHHHHHHTHHHHHHHHHHHHHTTTTCCSTTCHHHHHHHHHHHHHHHHHHHHHHHTTCCTTSS T ss_pred ccCCchHHHHHHHHhhhchHHHHHHHHHHHHHHHHHHHHHHhhccccHHHHHHHHHHHHHHHHHHHHHHHHHHhhhcccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 974 SSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFP 1053 (1273) Q Consensus 974 ssvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfp 1053 (1273) ||.+++|+.|||++||++|+||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+| T Consensus 1062 Sssi~gI~~RLd~lEA~iqvdrlInGRL~aLnafVtq~l~~~~~v~~sr~LA~qKiNECVKSQS~R~gFCGnGtHi~S~~ 1141 (1359) T 6Q04_B 1062 SASIGDIIQRLDPPEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQGTHIVSFV 1141 (1359) T ss_dssp CSCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTSSSSEEEEEEE T ss_pred hhcHhHHHHhcchHHHHhCCChhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCCCCeeEEEEe Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1054 QSAPHGVVFLHVTYVPAQEKNFTTAPAICHD---GKAHFPREGVFVSNG-----THWFVTQRNFYEPQIITTDNTFVSGN 1125 (1273) Q Consensus 1054 qsaphgvvflhvtyvpaqeknfttapaichd---gkahfpregvfvsng-----thwfvtqrnfyepqiittdntfvsgn 1125 (1273) |.||+|++|+|++|+|.+.++.+++|.+|++ +++..|+.|.|+.+. .+|++|.|++|||..||.+|+. --. T Consensus 1142 q~AP~Gi~F~H~~~~Pt~~~~V~a~~GlC~~~~~~~~~~p~~g~~v~~~~~~~~~~~~~T~r~~y~P~~~t~~dv~-i~s 1220 (1359) T 6Q04_B 1142 VNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSLNTK-YVA 1220 (1359) T ss_dssp EEETTEEEEEEEEEEEESCEEEEEESCEEESSSTTCEEEESSEEEEEC-------CEEEEETTEEEEECCCTTSEE-EEC T ss_pred eccCCeEEEEEEEeccCceeEEEEEeEEecCCCCCceeeccCeEEEEeCCceeeceEEEeCCccccCccCCccCEE-EEC Confidence 9999999999999999999999999999996 689999999999876 5799999999999999999955 577 Q sp|P0DTC2|SPIK 1126 CDVVIGIVNNTVYDPL--QPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1126 cdvvigivnntvydpl--qpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) |||....+|+++..|+ +|+...|+|||+|+|||+++...|+.+++.+|++++|++.||++|+|+.|+||+++|||++| T Consensus 1221 c~V~y~n~~~~~l~~~v~~pdyiDf~~el~~~~~n~~~~~p~l~~l~~~N~T~LNLt~EI~~Lq~~i~~LN~s~idLe~L 1300 (1359) T 6Q04_B 1221 PQVTYQNISTNLPPPLLGNSTGIDFQDELDEFFKNVSTSIPNFGSLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKEL 1300 (1359) T ss_dssp CCTTSEEECSSCCTTTCC-------------------------------------------------------------- T ss_pred CcceeEecCCCCCCCccCCCCCCChHHHHHHHHhcCCCCCCCCCccccceeeecchHHHHHHHHHHHHHHHhcCCCHHHh Confidence 8999999999999984 67999999999999999999888888899999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1204 GKYEQYIKWPWYIWLGFIAGL 1224 (1273) Q Consensus 1204 gkyeqyikwpwyiwlgfiagl 1224 (1273) ++||+||||||||||||-.|- T Consensus 1301 n~~e~YiKWPWYvWL~~~~~~ 1321 (1359) T 6Q04_B 1301 GNYTYYNKGSGRENLYFQGGG 1321 (1359) T ss_dssp --------------------- T ss_pred CceeEEeccCchhheeecCCC Confidence 999999999999999998763 No 4 >5I08_C Spike glycoprotein; coronavirus, glycoprotein, prefusion, VIRAL PROTEIN; 4.04A {Human coronavirus HKU1 (isolate N5)} Probab=100.00 E-value=1.5e-199 Score=1685.13 Aligned_cols=1142 Identities=29% Similarity=0.491 Sum_probs=772.9 Template_Neff=4.000 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNI------ 100 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng---tkrfdnpvlpfndgvyfasteksni------ 100 (1273) -+-.+|+||||..++++..+-.|+||.+.-++.+-.- .+|++- --.++++..||+||+++...+.+|- T Consensus 29 vs~~~G~yYPd~rvysN~TlL~qglfp~~gs~~~~y~---~~~t~~~~~~~~y~~~~~~F~dGifvkv~~~~n~t~~~~~ 105 (1299) T 5I08_C 29 VSLGLGTYYVLNRVYLNTTLLFTGYFPKSGANFRDLA---LKGSIYLSTLWYKPPFLSDFNNGIFSKVKNTKLYVNNTLY 105 (1299) T ss_dssp TTSSSSCBCCTTEECCSEEEEEEEEECCTTCEEEECC---CBCSSCEEGGGGSTTTEEECSSEEEEEEECCCEESSSCEE T ss_pred cccceeEEEecceEEeceeeeeeCeecCCCCceeeee---eecccccccceecCCCcccccCcEEEEeeecccCCCCccc Confidence 3556899999999999999999999999988876542 233332 3467888999999999998887764 Q sp|P0DTC2|SPIK 101 --IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMD 178 (1273) Q Consensus 101 --irgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmd 178 (1273) -..++||+|.+...++++|+++-+...|.+|.|..|..|.+.+++ |..+.. +++. ....+|+|.|. +.|-+| T Consensus 106 ~~~pa~~fGsTF~N~s~tvVI~P~~~~~~it~C~~~vC~~p~~~~~p--~~~~~~--~~~~-~d~~~~~~~~~-~nfT~d 179 (1299) T 5I08_C 106 SEFSTIVIGSVFVNTSYTIVVQPHNGILEITACQYTMCEYPHTVCKS--KGSIRN--ESWH-IDSSEPLCLFK-KNFTYN 179 (1299) T ss_dssp CCCCCEEEESSCSTTSCEEEEEEETTEEEEEEECCCCCSSCCBCCSS--SCCSCC--CTTS-TTCSCCCEEEE-EEEECC T ss_pred eecceeEEeccccCCcEEEEEeCCCceEEEEEEEEEecCCCceEEec--CCCccc--eeee-EeCCCCeEEEe-eccccc Confidence 356789999999999999999999999999999999999987776 332222 3334 56778888653 444343 Q sp|P0DTC2|SPIK 179 LEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGW 258 (1273) Q Consensus 179 legkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgw 258 (1273) ... ..| .|.|++.||.|-+|..+...+ ..| +...++|...+.+- .+-|+..++ ++.+ T Consensus 180 ~~~--~~~----~f~F~~~dG~f~~Yyad~~~~------~~f-----~f~~~~~~~~~~yy---vip~~~~~~---~~~~ 236 (1299) T 5I08_C 180 VSA--DWL----YFHFYQERGVFYAYYADVGMP------TTF-----LFSLYLGTILSHYY---VMPLTCNAI---SSNT 236 (1299) T ss_dssp TTC--SEE----EEEEEEETTEEEEEEESSCSS------BEE-----EEEEECCSCCCEEE---ECCBCSTTS---SSSG T ss_pred ccc--eee----EEEEEEeCCEEEEEEeccCCC------cce-----eecccceeecceee---eceeeccCC---CCCC Confidence 322 111 299999999998875543222 111 11111232222222 333444444 5667 Q sp|P0DTC2|SPIK 259 TAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPF 338 (1273) Q Consensus 259 tagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpf 338 (1273) ....++|||++|.+|+|||+|+.||.|++||||+-|+++|-||..+||.+++|+|++|+||+||...++|.+.....|+| T Consensus 237 ~~~~~~~~v~~L~~~~~Ll~fd~~G~It~AvDC~~~~~sEL~C~t~Sf~~~tGVY~lS~y~aqP~~~V~~~~~~~~~C~~ 316 (1299) T 5I08_C 237 DNETLEYWVTPLSRRQYLLNFDEHGVITNAVDCSSSFLSEIQCKTQSFAPNTGVYDLSGFTVKPVATVYRRIPNLPDCDI 316 (1299) T ss_dssp GGCCCCEEEEECEEEEEEEEECTTCCEEEEECGGGCHHHHHHHHHTSSSCCSCEEEEC--------CEEECCSSCCCCCH T ss_pred CccceeEEEeecccceEEEEeCCCCeEeEEEecccCcchhheeeecccCCCCCeeecCCeEEEeeeEEEEecCCCCCCCH Confidence 78889999999999999999999999999999999999999999999999999999999999999999999999899999 Q sp|P0DTC2|SPIK 339 GEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKI 418 (1273) Q Consensus 339 gevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgki 418 (1273) .+++++.++.++|.|.|+.++||..|+++|++..++++|+|||+||.||.+.||..|++|.|.|..+..++++||++|-| T Consensus 317 ~~~~~~~~~P~p~~w~R~~f~nCnfn~s~Lls~~~~~~f~C~~ispskl~~mCfsSvtiD~Faip~s~~~~L~~g~~g~i 396 (1299) T 5I08_C 317 DNWLNNVSVPSPLNWERRIFSNCNFNLSTLLRLVHVDSFSCNNLDKSKIFGSCFNSITVDKFAIPNRRRDDLQLGSSGFL 396 (1299) T ss_dssp HHHHTCSEEECGGGCEEEEECSCEECHHHHHHTSEEEEEEEESSCHHHHHHCCCSCEEEEEEECCSTTGGGGSSSCCSSC T ss_pred HHHhhCCCCCCccceEEeEEecCCCCHHHHHhhceeeeeeeeCCCHHHhcccccCeeEEEEEeccCcchHhcCCCCCcHh Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 419 ADYNYKLPDDFTGCVIAWNSNNLDSKV----GGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCN------------- 481 (1273) Q Consensus 419 adynyklpddftgcviawnsnnldskv----ggnynylyrlfrksnlkpferdisteiyqagstpcn------------- 481 (1273) ++||||+|++|+||+++|+-.+.+..+ -++||.-|+. +..++++.++..+..-..++++-|. T Consensus 397 ~~~NYkl~~~~~sC~l~~~~~~~~vt~t~~nps~~n~ry~~-~~~~~~~hdv~Ys~~cf~~~~~~cPC~~p~~~~~~~~~ 475 (1299) T 5I08_C 397 QSSNYKIDISSSSCQLYYSLPLVNVTINNFNPSSWNRRYGF-GSFNLSSYDVVYSDHCFSVNSDFCPCADPSVVNSCAKS 475 (1299) T ss_dssp CCCCCCCCCSSSEEEEEEEEESSSCEEECCCCSCCTTTCCC-CCCSSEEECCCSCCCCCTTCCCCCCC------------ T ss_pred HhccccCCCCCCceEEEEEcccccceecCCCcccchhccCc-cccCCCccceeeeccccccCCCCCCCCChhhcccCcCC Confidence 999999999999999999966655444 3567766665 6667888888888777766655443 Q sp|P0DTC2|SPIK 482 --------------------------------GVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFEL------------ 517 (1273) Q Consensus 482 --------------------------------gvegfncyfplqsygfqptngvgyqpyrvvvlsfel------------ 517 (1273) +..+..|+-+...+.....-|+|++.+++.|++.+. T Consensus 476 ~~~~~~~~~~t~~r~c~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~q~~~~vg~g~~c~g~~V~~~k~g~~~~~~~c~c~ 555 (1299) T 5I08_C 476 KPPSAICPAGTKYRHCDLDTTLYVKNWCRCSCLPDPISTYSPNTCPQKKVVVGIGEHCPGLGINEEKCGTQLNHSSCFCS 555 (1299) T ss_dssp -------------------------------------------------------------------------------- T ss_pred CCCCCCCCCCCcceecccccccccccccccccCCCCCCccCCCCCCCceeeeecccccCeeEEEeeecCCCCCCCCcccC Confidence 111344554554444455679999999999999888 Q sp|P0DTC2|SPIK 518 ---------------------------LHAPATVCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTE-SNKKFLPFQQFG 566 (1273) Q Consensus 518 ---------------------------lhapatvcgp---kkstnlvknkcvnfnfngltgtgvlte-snkkflpfqqfg 566 (1273) ...++|+|+. +.+++++.++||++|..|.||+||+++ ++..++.+|.+. T Consensus 556 ~~af~gws~dsc~~~~~~~~~~~~~~~~~~t~Tvcp~~~~~~~snI~Ln~CVdYNIYG~TGtGVItnvt~s~~~~~qGL~ 635 (1299) T 5I08_C 556 PDAFLGWSFDSCISNNRCNIFSNFIFNGINSGTTCSNDLLYSNTEISTGVCVNYDLYGITGQGIFKEVSAAYYNNWQNLL 635 (1299) T ss_dssp ---CCSCCEEECCBTTEEEEEEEEEESSSSSSSCEECTTCCCCCCCCCSSSEEEEETTEEEEEEEEECCCCCCCTTTCEE T ss_pred ccccccccccccccCCccccccceeccCCCCCCcCCCccccCCceeEeCeeEeEEeCCCeeEEEEEeCCCceeecCCcEE Confidence 5668999998 467899999999999999999999999 444467788888 Q sp|P0DTC2|SPIK 567 RDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTR 646 (1273) Q Consensus 567 rdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtr 646 (1273) .|-+.-..++|++.++++..|+||..+.++++..|. +...+.+++.++|.++..... +....+-|+|. T Consensus 636 ydssGdLlgFKn~ttg~iYsV~PC~~v~vqvVv~~~--~~vgall~~n~~cs~~~~n~~----------~~~~~~~~~t~ 703 (1299) T 5I08_C 636 YDSNGNIIGFKDFLTNKTYTILPCYSGRVSAAFYQN--SSSPALLYRNLKCSYVLNNIS----------FISQPFYFDSY 703 (1299) T ss_dssp EETTEEEEEEECTTTCCEEEEECCCCCCEEEECCCC-----CEEEEETCCHHHHHHTC----------------CCEECS T ss_pred EeCCCCEEEEEeCCCCcEEEEEeCcccceEEEEeCC--CcceeEEeecCcccceeecee----------eecCccceecc Confidence 888888889999999999999999999999998876 344689999999988765311 22222559999 Q sp|P0DTC2|SPIK 647 AGCLIGAEHVNN--SYECDIPIGAGICASYQTQTNSPRRARSVAS--QSIIAYTMSL-----GAENSVAYSNNSIAIPTN 717 (1273) Q Consensus 647 agcligaehvnn--syecdipigagicasyqtqtnsprrarsvas--qsiiaytmsl-----gaensvaysnnsiaiptn 717 (1273) .||.+++++... ..+|+.|.|.|+|+.+.+. +++++++..+ .++..| +.. -....+..+...|.||+| T Consensus 704 ~gc~~~~~~~t~~~v~~c~~~~~~~~C~~~~~~--~~~g~~~~~~~~~~l~~~-~p~~~~~~~~~~~~~~~~~~IsIPtN 780 (1299) T 5I08_C 704 LGCVLNAVNLTSYSVSSCDLRMGSGFCIDYALP--SSGGSGSGISSPYRFVTF-EPFNVSFVNDSVETVGGLFEIQIPTN 780 (1299) T ss_dssp SEEESSCBCCCSSBCSSCSCBCSTTEEEEC----------------CCEEEEC-CCCC---------------------C T ss_pred cceeeeceeccCCccccCccccCCceeeecCCC--CCCCCCCCcCCCeeeeEe-cceeeeecCCcccccceEEEEEccCC Confidence 999999976644 7789999999999999877 5555554332 234443 221 011124445558999999 Q sp|P0DTC2|SPIK 718 FTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTP-P--- 793 (1273) Q Consensus 718 ftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktp-p--- 793 (1273) |||+|++|-++++|.|.+|||.+|+||++.+|.+||.|||+||..+++||.|.+..+|....+++..+++-++++ + T Consensus 781 FTisv~~EyiQt~~~kVsVDCa~YVCngn~~C~~lL~qYgs~C~~i~~~l~~~~~~~~~~~~~~~~~~~~~~~~ss~~~~ 860 (1299) T 5I08_C 781 FTIAGHEEFIQTSSPKVTIDCSAFVCSNYAACHDLLSEYGTFCDNINSILNEVNDLLDITQLQVANALMQGVTLSSNLNT 860 (1299) T ss_dssp CCCCEEEECCCCCCCEEEECTTTTTCCSCTHHHHHHHHHCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCTTCCC T ss_pred ceeEEEEEEeeccCCCeEEecceeecCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhhcHHHHHHHHHHhccccccccccc Confidence 999999999999999999999999999999999999999999999999999999999999999999999988775 3 Q sp|P0DTC2|SPIK 794 --IKDFGGFNFSQILPDPSK---PSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDE 868 (1273) Q Consensus 794 --ikdfggfnfsqilpdpsk---pskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltde 868 (1273) +..+++|||+.+||.+.. +++||+||||||+||..+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++| T Consensus 861 ~~~~~~~~~N~s~ll~~~~~~~~~~~RS~IEDLLF~KV~t~glG~~~~Y~~Ct~g~~i~DL~CaQ~yNGi~VLP~v~d~~ 940 (1299) T 5I08_C 861 NLHSDVDNIDFKSLLGCLGSQCGSSSRSLLEDLLFNKVKLSDVGFVEAYNNCTGGSEIRDLLCVQSFNGIKVLPPILSET 940 (1299) T ss_dssp ----------------------------CHHHHGGGTSCCCHHHHHHHHHTTSSSCSCCTTHHHHHHSSEEEECCSSCHH T ss_pred CcccCCCCccchhhcccccCCCCCCcccHHHHHhcCceEeCCCChhHHHHHccCCccHHHHhcccccCeEEEeCCCCCHH Confidence 378899999999998763 479999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 869 MIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKL 948 (1273) Q Consensus 869 miaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgkl 948 (1273) |+|.||++|++|....|||+ |..||||+||.||+||+|+||+||.||||+|||.||.||+.||+.+.++++||.|+ T Consensus 941 ~~amYTasL~g~m~~gg~T~----aaaIPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~iq~~f~~~~~Al~ki 1016 (1299) T 5I08_C 941 QISGYTTAATVAAMFPPWSA----AAGVPFSLNVQYRINGLGVTMDVLNKNQKLIANAFNKALLSIQNGFTATNSALAKI 1016 (1299) T ss_dssp HHHHHHHHHHHHHHCTTTCS----SSSSCHHHHHHHHHTTSSCSSSHHHHTTTHHHHHHHHHHHHHHGGGGSCCSHHHHH T ss_pred HHHHHHHHHHHHhhccCchh----cccCchHHHHHHHhchhcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999997 55689999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 949 QDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATK 1028 (1273) Q Consensus 949 qdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatk 1028 (1273) |||||++++||++|++||+.|||||||.++||++|||++||++||||||+|||.+|++||+|||+|++|+|||+.||..| T Consensus 1017 Q~VVN~~~~aL~~L~~qL~~nFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtQ~L~~~~evr~sr~LA~qK 1096 (1299) T 5I08_C 1017 QSVVNANAQALNSLLQQLFNKFGAISSSLQEILSRLDNLEAQVQIDRLINGRLTALNAYVSQQLSDITLIKAGASRAIEK 1096 (1299) T ss_dssp HHHHHHHHHHHHHHHHGGGCCSSSSSCSTHHHHHHCCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHcHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1029 MSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQR 1107 (1273) Q Consensus 1029 msecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqr 1107 (1273) |.|||..||+|.+|||.|.|++|+||.||+|++|+|++|+|.+.++.+++|.+|+++ ++..|++|+|+.+...|++|.| T Consensus 1097 INECVkSQS~R~gFCGnGtHi~Si~q~APnGi~FlH~~y~Pt~~~~V~a~~GlC~~~~~~~~~~~g~f~~~n~~~~~T~r 1176 (1299) T 5I08_C 1097 VNECVKSQSPRINFCGNGNHILSLVQNAPYGLLFIHFSYKPTSFKTVLVSPGLCLSGDRGIAPKQGYFIKQNDSWMFTGS 1176 (1299) T ss_dssp CCCCCTSCCSCSSSSCSSCCSEEEEEEETTEEEEEEEC------------------------------------------ T ss_pred HHHHHhcCCCCccccCCCeEEEeeeeccCCeEEEEEEEecCCeeeEEEEEeeEEecCCeeEEecCcEEEeeCCEEEEecc Confidence 999999999999999999999999999999999999999999999999999999995 7999999999999999999999 Q sp|P0DTC2|SPIK 1108 NFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLN 1187 (1273) Q Consensus 1108 nfyepqiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrln 1187 (1273) ++|||..||.+|...-..|||....+|+++..+..|++..|+|||+|+|||+++...|+.++..+|++++|++.||++|+ T Consensus 1177 ~~y~Pr~~t~~d~v~~~sC~v~y~n~~~~~~~~~~p~~~df~~el~~~~~n~~~~~p~~~~~~~~n~t~LNLt~EI~~Lq 1256 (1299) T 5I08_C 1177 SYYYPEPISDKNVVFMNSCSVNFTKAPFIYLNNSIPNLSDFEAELSLWFKNHTSIAPNLTFNSHINATFLDLYYEMNVIQ 1256 (1299) T ss_dssp -------------------------------------------------------------------------------- T ss_pred ccccCCCCCccCeEEeccceeEEEEcChhhCCCCCCCCCChHHHHHHHHhcCCCCCCCCCcccccccceechHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999977888878899999999999999999 Q sp|P0DTC2|SPIK 1188 EVAKNLNESLIDLQELGKYEQYIKW-PWYIWLGFIAG 1223 (1273) Q Consensus 1188 evaknlneslidlqelgkyeqyikw-pwyiwlgfiag 1223 (1273) |+.|+||+++.+++.+.+.|.|+|| |||+||..+.. T Consensus 1257 evIknLN~S~~ilE~l~~~e~YVkwdpwwVwL~i~l~ 1293 (1299) T 5I08_C 1257 ESIKSLNGSGYIPEAPRDGQAYVRKDGEWVLLSTFLG 1293 (1299) T ss_dssp ------------------------------------- T ss_pred HHHHHHHhcCCCCCCCCCccceecccChhHHHHhhhh Confidence 9999999999999999999999998 99999976543 No 5 >5X5F_B S protein; MERS-CoV, spike glycoprotein, prefusion, single; 4.2A {Middle East respiratory syndrome coronavirus} Probab=100.00 E-value=6.1e-198 Score=1670.09 Aligned_cols=1163 Identities=31% Similarity=0.500 Sum_probs=888.5 Template_Neff=3.800 Q sp|P0DTC2|SPIK 14 QCVNL-TTRTQLPPAYT----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRF 79 (1273) Q Consensus 14 qcvnl-ttrtqlppayt----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krf 79 (1273) .|... -...-+.+.++ -+-.+|+||||..++++..+-.|+||.+.-++.+-.- ++|++. + -.+ T Consensus 12 ~C~~~~~~~~~~~~~~~~~idvs~~~G~yYP~~rvysN~TlL~qglfP~~gs~~~~y~---~~~t~~~~~~~~~~~~~~y 88 (1323) T 5X5F_B 12 ACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANY 88 (1323) T ss_dssp BCCCEEECGGGTCCCCCCCCCGGGTTTCBCCSSCCBSSCEEEEEEEECCTTCCCEEEC---CEECCBCSSCBCSEEECSG T ss_pred cceecccccccCCCCCCcceecccCceeEeeCCeeeeeeeeeeeceecCCCCcceEEE---EEecCCCCCCCcceeeecc Confidence 36554 23333445555 3446899999999999999999999999988876532 333333 1 356 Q sp|P0DTC2|SPIK 80 DNPVLPFNDGVYFASTEKSNIIR-----------------GWIFGTTLDSKT---Q------SLLIVNNATNVVI----- 128 (1273) Q Consensus 80 dnpvlpfndgvyfasteksniir-----------------gwifgttldskt---q------sllivnnatnvvi----- 128 (1273) +.+..||+||+++...+..|--. .++||+|.+... + +++|+++-.+.++ T Consensus 89 ~~~~~~F~dGifvkv~~~~n~tg~~~~~~~~~~~~~~~ypa~~fGstF~Nts~~~~~~~~~~tlVI~P~~~g~~~~~~~~ 168 (1323) T 5X5F_B 89 SQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYC 168 (1323) T ss_dssp GGCCEECTTCEEEEESTTTTSEEECSSSTTCEEEEECCCCCEEEESCEEECTTSCEEEECSEEEEEEEETTTTEEEEEEE T ss_pred CCChhhccCeEEEEEeeeeccCCCeeeCCccccchhhhccceEeeccccCCCCCccccccceEEEEecCCCCchheeeee Confidence 77899999999998877666422 256999998666 5 8889888876543 Q sp|P0DTC2|SPIK 129 --KVCEFQFCNDPFLGVYYHKNN---KSWMES---------EFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVF 194 (1273) Q Consensus 129 --kvcefqfcndpflgvyyhknn---kswmes---------efrvyssannctfeyvsqpflmdlegkqgnfknlrefvf 194 (1273) ...+..-|..|..-+++.-+. .+|..+ +++.|....+|+|.|. +.|-+|... ..|- |.| T Consensus 169 ~~~prtit~C~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~nfT~d~~~--~wf~----~~F 241 (1323) T 5X5F_B 169 ILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYT-YNITEDEIL--EWFG----ITQ 241 (1323) T ss_dssp EEEECCSBTSTTSTTCCCCCEEECHHHHSCTTCCCTTHHHHHHHHHEEEEEEEEEEE-EECCCCCCC--EEEE----EEE T ss_pred cccccccCcCCCCCeEeeeeecCCCCccCCCCcccccccccchhHhcccCCceEEEe-eecCcchhh--heee----EEe Confidence 322333455555555432221 345333 6778889999999875 344333211 1111 899 Q sp|P0DTC2|SPIK 195 KNID-GYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 195 knid-gyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) +..| |.|-+|.-++..+. ..-+| |+..+.+.. .+-|+..++ .+.+. ..++|||++| T Consensus 242 ~~~~~G~f~~Y~~d~~~~~~f~f~~~~-~~~~~~yy~---------------v~p~~~~~~---~~~~~-~~~~~~v~~L 301 (1323) T 5X5F_B 242 TAQGVHLFSSRYVDLYGGNMFQFATLP-VYDTIKYYS---------------IIPHSIRSI---QSDRK-AWAAFYVYKL 301 (1323) T ss_dssp ETTEEEEEESTTTCTTTCCBEEEEEEC-CCSCCCEEE---------------ECCEEECCC---GGGCC-EECCEEEEEC T ss_pred eecCceeEEEEEEeccCCcceeccccc-ceeccceee---------------eeeeeecCC---ccccc-eeEEEEEEEc Confidence 9999 99999876654332 12222 444444443 233444444 45566 7889999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASV 350 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasv 350 (1273) .+|+|||+|++||.|++||||+-|+++|-||..+||.+++|+|++|+||+||....+|.++. ..|+|.++++ .++.++ T Consensus 302 ~~~~yLl~fd~nG~I~~avDC~~~~~seL~C~~~sf~~~tGVY~~S~y~aqp~~~v~~~~~~-~~C~~~~~~~-~~~P~p 379 (1323) T 5X5F_B 302 QPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEG-VECDFSPLLS-GTPPQV 379 (1323) T ss_dssp EEEEEEEEECTTSCEEEEEETTSCHHHHHHHTTTCSCCCSSEECCCCCBBCCCSCEECC----CCCCCHHHHS-BCCCBG T ss_pred cceeEEEeecCCCeEEEEEecCCCccchheeEeceecCCCCeeecCCEEEEeeeEEEEecCC-CCCCchHHhc-CCCCCc Confidence 99999999999999999999999999999999999999999999999999999999999999 9999999999 889999 Q sp|P0DTC2|SPIK 351 YAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT 430 (1273) Q Consensus 351 yawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddft 430 (1273) |.|.|+.++||..|+|+|++...+++|+||||+|.||.++||..|++|.|.|..+..++++||++|-|++||||+|+||+ T Consensus 380 ~~w~R~~f~nCnfN~s~Lls~~~~~sf~C~gIspskLa~mCfsSvtiD~Faip~s~~~~Lq~G~~G~i~~yNYKld~~~~ 459 (1323) T 5X5F_B 380 YNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNP 459 (1323) T ss_dssp GGCEEEEECSEEECHHHHHHHSEEEEEEEESSCHHHHHHSCCSCEEEEEEECCGGGGGGSCTTCCSHCCCCCCCCCSSSC T ss_pred ceeEEeEEecCCCcHHHHHhhceeeeeeecCCCHHHHcccccceeeEEEEecCccccceecCCCCChhhhccccCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 431 GCVIAWNSNNLDSKV--GGNYNYLYRLFRKSNLKPFERDISTEI---YQAGSTPCNGV-EGFNCYFPLQSY--------- 495 (1273) Q Consensus 431 gcviawnsnnldskv--ggnynylyrlfrksnlkpferdistei---yqagstpcngv-egfncyfplqsy--------- 495 (1273) ||+++|+-...+..+ -.+|+|+.|-+++.. ++. ++. ..+ .+-|+-. ...+|+.|...+ T Consensus 460 sC~l~y~~pa~~vn~t~p~~y~yi~~~~~~~~-----~~~-~~~~~~~~~-~~~cpc~~~~~~~~~~~~~~~~~~~~~~~ 532 (1323) T 5X5F_B 460 TCLILATVPHNLTTITKPLKYSYINKCSRLLS-----DDR-TEVPQLVNA-NQYSPCVSIVPSTVWEDGDYYRKQLSPLE 532 (1323) T ss_dssp EEEEEEECCSSCCSBCCCSEEEEEEEEEEECT-----TSS-CEEECCCCT-TSCCTTTTTSCSSCSSTTCEEEEECCTTT T ss_pred ccEEEEEcCccccccCCCccceeeeeeeccCC-----CCC-Ccchhhccc-cccCCCCccCCccccCCCCcccccccccc Confidence 999999955533322 445666555555433 222 222 111 1111100 012344443222 Q sp|P0DTC2|SPIK 496 --GFQP----TNGVGYQPYRVVVLSFELLHAPATVCGP-----KKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQ 564 (1273) Q Consensus 496 --gfqp----tngvgyqpyrvvvlsfellhapatvcgp-----kkstnlvknkcvnfnfngltgtgvltesnkkflpfqq 564 (1273) |..+ ..++++|++.++|++++..+.++|||++ |.+|.++.++||++|+.|+||+||++|++..+..+|. T Consensus 533 ~~~~~~~~~~~~~~~~~~~g~~Vis~k~~~~s~tVCp~~~d~~~~~T~~~l~vCV~YnlYGiTGtGVf~~sn~~~~~~Q~ 612 (1323) T 5X5F_B 533 GGGWLVASGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQR 612 (1323) T ss_dssp TSSEEEEEEEEEECCSSCEEEEEEECCCCSSCCCEEECC------CCSSSCCCSSCEECSSCCCCCCCEECCCCSCSSSC T ss_pred CCchhcccccccccccceeEEEEEEeEcCCCccccCCCcccCCcCCcchhcCceeeEEecceeeeEEEEecCccccccee Confidence 2233 4589999999999999999999999988 5668999999999999999999999999999999999 Q sp|P0DTC2|SPIK 565 FGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRV--YSTGSNV 642 (1273) Q Consensus 565 fgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrv--ystgsnv 642 (1273) |..|-.+-..+.|| +++++.+|+||..|+|||+++++ ++..|+||++++|.+|...+|..+.+|.|+. ++...+. T Consensus 613 f~yds~Gnl~gfk~-~tg~vY~I~PC~s~~VSViy~~~--s~e~AlLf~~v~C~~v~t~~~~~~~~~~~~~~~~~~~~~~ 689 (1323) T 5X5F_B 613 FVYDAYQNLVGYYS-DDGNYYCLRACVSVPVSVIYDKE--TKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGP 689 (1323) T ss_dssp CCBCSSSCBCCCCC-SSSCCEECCCCCBCCCBEECCTT--TTCCCCBCSSCCTTTCCTTCTTBSCSSSSCCC-------- T ss_pred EEEcCCCCEEEEEe-CCCCEEEEeeceeeceeEEEeCC--CCceEEEeCCccccceecceeeecCCCchhcccccCCCCC Confidence 99999999999999 99999999999999999999998 7799999999999999999999999999998 7778889 Q sp|P0DTC2|SPIK 643 FQTRAGCLIGAEHVNN-SYECDIPIGAGICASYQTQTNS-PRRARSVAS-QSII--AYTMSLGAENSVAYSNNSIAIPTN 717 (1273) Q Consensus 643 fqtragcligaehvnn-syecdipigagicasyqtqtns-prrarsvas-qsii--aytmslgaensvaysnnsiaiptn 717 (1273) |||-+||++||++.+. .+|||+|+|+|+|+.|.+...+ +|+.|++.. ..+. +|+|.+-. .++.+++..|.||+| T Consensus 690 fdT~~GCVvnA~n~t~~V~~C~lplG~glC~~y~~~s~~~~r~~~~~~~~~~l~~~~y~~p~~~-~~~~~~~~~i~IP~n 768 (1323) T 5X5F_B 690 LQTPVGCVLGLVNSSLFVEDCKLPLGQSLCALPDTPSTLTPRSVSSVPGEMRLASIAFNHPIQV-DQLNSSYFKLSIPTN 768 (1323) T ss_dssp ---CBCCSSSCBSSCCCCCCCCCCCTTCCSSSCCCCCC------------CCCCCCCCCCCCCC-CCCCSSCCEEEECCC T ss_pred CCCccceeeecccCCCceeeCCCCCCcceecCCCCcCcCccccccCCCCceEEEEEeecCCeee-cccCCCCeeEEcccc Confidence 9999999999999988 8999999999999999988755 344444443 3344 67777765 778889999999999 Q sp|P0DTC2|SPIK 718 FTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF 797 (1273) Q Consensus 718 ftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdf 797 (1273) |||+|++|-+.++|.|.+|||.+|+||++.+|.+||.|||+||..+|+||.|.+.++|.+..+++..+++-++.+-+..| T Consensus 769 Ft~~v~~EyiQ~~~~kv~iDC~~YVC~~~~~C~~lL~qYgs~C~~I~~aL~~~~~~~d~~~~~~~~~~~~~~~~~~~~~f 848 (1323) T 5X5F_B 769 FSFGVTQEYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLFASVKSSQSSPIIPGF 848 (1323) T ss_dssp CCCCCCCCBCCCCCCCCEECTTSSSSSSCHHHHHHHHTSHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCSSCCCCCCSCC T ss_pred eEEEEEEEEEeecCCceEEechhhccCCCHHHHHHHHHHHHHHHHHHHHHHHHhhhccHHHHHHHHhccccccCCCcCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999998888887 Q sp|P0DTC2|SPIK 798 -GGFNFSQILPDPS---KPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDI--AARDLICAQKFNGLTVLPPLLTDEMIA 871 (1273) Q Consensus 798 -ggfnfsqilpdps---kpskrsfiedllfnkvtladagfikqygdclgdi--aardlicaqkfngltvlpplltdemia 871 (1273) |+|||+.+||.+. ++++||+||||||+||.+.|.||.+.|+.|.... ..|||+|||.+||+.||||..++||.+ T Consensus 849 ~~~~N~s~ll~~~~~~~~~~~RS~iEDLLF~KV~t~g~G~~~~Y~~C~~g~~~~i~DL~CAQ~yNGi~VLP~v~~~~le~ 928 (1323) T 5X5F_B 849 GGDFNLTLLEPVSISTGSRSARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEA 928 (1323) T ss_dssp BTTBCCTTSCCC--------CCCHHHHHHHHSSCCCCCCSSSHHHHHHTC--------CCTTTSCSEECCCCSSCHHHHH T ss_pred CCCcccceeccCCCCCCCccceeHHHHHhcceeeeCCCCcccChhhhcccCCccHHHHhheeEeCCEeecCCcCCHhHHH Confidence 5799999999876 3468999999999999999999999999999554 899999999999999999999999999 Q sp|P0DTC2|SPIK 872 QYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDV 951 (1273) Q Consensus 872 qytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdv 951 (1273) +|+.+++.+....||++|..++..|||++++.+|+|++++++++|.+|||.|||.||.|||.||+.+.++++||.|+|++ T Consensus 929 ~yt~SdvG~l~~~r~e~G~tsaaaIpfs~~Vy~RLN~l~~~~~vL~~nq~~Ia~sFN~aIg~iq~gf~t~~~Al~kIq~v 1008 (1323) T 5X5F_B 929 AYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFQKVQDA 1008 (1323) T ss_dssp HHHHHHHHHHHHHTTCSCCC-CCCCCHHHHHHHHHHHSSCCCHHHHHTTCCSHHHHHHHHHHHHHCCTTTCTTHHHHHHH T ss_pred HHHHHHHHhhhcccccccCCccccCCchHHHHHHHHhhhchHHHHHHHHHHHHHHHHHHHHHHhhccccHHHHHHHHHHH Confidence 99999999888889999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 952 VNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSE 1031 (1273) Q Consensus 952 vnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmse 1031 (1273) ||+++++|++|..||+.|||||||.+++|+.|||++||++|+||||+|||.+|.+||+|||+|++|+|+|+.||..|+.| T Consensus 1009 VN~~~~als~L~~qLn~~FgAISssi~gI~~RLd~lEa~iqvdrlInGRL~aLn~~Vtq~l~~~~~v~~sr~LA~qKiNE 1088 (1323) T 5X5F_B 1009 VNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQLAKDKVNE 1088 (1323) T ss_dssp HHHHHCCCCCHHHHHSSSCSSSCSSSTTTTTSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC T ss_pred HHHHHHHHHHHHHHHhhhcccchhcHhHHHHHHHHHHHHhCCChhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1032 CVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHD---GKAHFPREGVFVSNG-----THWF 1103 (1273) Q Consensus 1032 cvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichd---gkahfpregvfvsng-----thwf 1103 (1273) ||..||+|.+|||.|.|++|+||.||+|++|+|.+|+|.+.++.+++|.+|++ +++..|+.|.|+.+. .+|+ T Consensus 1089 CVKSQS~R~gFCGnG~Hi~S~~q~AP~Gi~F~H~~~~Pt~~~~v~a~~GlC~~~~~~~~~~~~~g~~~~~~~~~~~~~~~ 1168 (1323) T 5X5F_B 1089 CVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNNTRIVDEWS 1168 (1323) T ss_dssp CCCSCCSSSTTSCSSSEEECCBCCCSSSCBBCCEECCCCCCEEEECCSCCCCSSCCCCCCSSSCCCCSSSSCCCCSSSCC T ss_pred HHHhcccccCCCCCCeeeEEeeeccCCeEEEEEEEecccceeEEEEEEEEeecCCCCceeeccCeEEEEeCCceeeceEE Confidence 99999999999999999999999999999999999999999999999999996 688999999999876 5699 Q sp|P0DTC2|SPIK 1104 VTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPL--QPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQK 1181 (1273) Q Consensus 1104 vtqrnfyepqiittdntfvsgncdvvigivnntvydpl--qpeldsfkeeldkyfknhtspdvdlgdisginasvvniqk 1181 (1273) +|.|++|+|..||.+|+. --.|+|...-+|+++..|+ +|+...|+|||+|+|||+++...|+.++..+|+++.|++. T Consensus 1169 ~T~r~~y~P~~~t~~~v~-i~sc~V~y~n~~~~~l~~~v~~p~yiDfn~el~~~~~n~~~~~p~l~~l~~fN~T~LNLt~ 1247 (1323) T 5X5F_B 1169 YTGSSFYAPEPITSLNTK-YVAPQVTYQNISTNLPPPLLGNSTGIDFQDELDEFFKNVSTSIPNFGSLTQINTTLLDLTY 1247 (1323) T ss_dssp CCCCSSSCCCCCCCSSTT-SCC---------------------------------------------------------- T ss_pred EeCCccccCccCCCCCEE-EECCcceEEecCCCCCCCccCCCCCCChHHHHHHHHhcCCCCCCCCCchhcceecccchHH Confidence 999999999999999955 5778999999999999984 6899999999999999999988888889999999999999 Q sp|P0DTC2|SPIK 1182 EIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGF 1220 (1273) Q Consensus 1182 eidrlnevaknlneslidlqelgkyeqyikwpwyiwlgf 1220 (1273) ||++|+|+.|+||+++|||++|++||+|||||||+--|- T Consensus 1248 EI~~Lq~~i~~LN~s~idLe~Ln~~e~YiKW~~~~~~~~ 1286 (1323) T 5X5F_B 1248 EMLSLQQVVKALNESYIDLKELGNYTYYNKEFRLVPRGS 1286 (1323) T ss_dssp --------------------------------------- T ss_pred HHHHHHHHHHHHHhccCCHHHhCceeeeEeeeeecCCCC Confidence 999999999999999999999999999999999987653 No 6 >6VSJ_A Spike glycoprotein, Carcinoembryonic antigen-related cell; MHV spike, CEACAM1a, Complex, Glycoprotein; HET: NAG; 3.94A {Murine coronavirus (strain A59)} Probab=100.00 E-value=2.1e-195 Score=1649.54 Aligned_cols=1145 Identities=30% Similarity=0.512 Sum_probs=889.4 Template_Neff=4.000 Q sp|P0DTC2|SPIK 9 PLVSSQCVNLTTRTQLP---PAYT-----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAI--HVSGTNGTKR 78 (1273) Q Consensus 9 plvssqcvnlttrtqlp---payt-----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhai--hvsgtngtkr 78 (1273) ++....|...-...-++ |.++ -+-.+|+||||..++|+..+-.|+||.+.-++.+-+-.- |... .--. T Consensus 22 ~i~~~~C~~~~~~~~~~~~~~~~s~~~idvs~~~G~yYPd~rvysN~TlL~qGLFP~~gs~~~~Y~~sgt~~~s--~~~~ 99 (1275) T 6VSJ_A 22 YIGDFRCIQLVNSNGANVSAPSISTETVEVSQGLGTYYVLDRVYLNATLLLTGYYPVDGSKFRNLALRGTNSVS--LSWF 99 (1275) T ss_dssp CCSSBCCCCCSEECCCCCCCCCCCSCBCCCTTSTTCBCCTTCBCCSCCCEEEEEEECTTCBCCBCCCEESSEEC--GGGS T ss_pred cccCcceeEeecCCCCCCCCCCCcceeeeeecceeEEEeCCeEEeceeeeeccccCCCCCceeeEEeeccCCCC--cccc Confidence 34555677653333333 3444 345689999999999999999999999998887654222 2222 1346 Q sp|P0DTC2|SPIK 79 FDNPVLPFNDGVYFASTEKSNI--------IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNK 150 (1273) Q Consensus 79 fdnpvlpfndgvyfasteksni--------irgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnk 150 (1273) +++++.||+||+++...+.+|- -..++||+|.+..+++++|+++-+...|.+|.|..|..|...+++.-+|. T Consensus 100 y~~~~~~F~dGIfVkV~~~kn~t~~~~~~~ypa~~fGSTF~Nts~tvVI~P~~~~r~itvCq~~vC~~p~~~~~p~~g~~ 179 (1275) T 6VSJ_A 100 QPPYLNQFNDGIFAKVQNLKTSTPSGATAYFPTIVIGSLFGYTSYTVVIEPYNGVIMASVCQYTICQLPYTDCKPNTNGN 179 (1275) T ss_dssp STTTSCCCSSCEEEEEECCGGGSCTTCCCSSCCEEEESSCSTTSCEEEECEETTEECCEEECCCBBSSCCEESSCCCSSC T ss_pred cCCcccccCCcEEEEeeeeccCCCCcchhccceeEEecccCCCceEEEEeCCCceeEeEEEEEEEcCCCeeEEccCCCCC Confidence 7788999999999998887765 35678999999999999999999999999999999999999888744332 Q sp|P0DTC2|SPIK 151 SWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLV 227 (1273) Q Consensus 151 swmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplv 227 (1273) +..+ ++. ....+|+|.|. +.|-+|... ..|- |.|+..||.|-+|..+...+. ..-+| |...+.+. T Consensus 180 ~~~~--~~~-~d~~nc~f~~~-~nfT~d~~~--~~~~----~~F~~~dG~fy~Yyad~~~~~~f~f~~~~-~~~~~~yy- 247 (1275) T 6VSJ_A 180 KLIG--FWH-TDVKPPICVLK-RNFTLNVNA--DAFY----FHFYQHGGTFYAYYADKPSATTFLFSVYI-GDILTQYY- 247 (1275) T ss_dssp TTCC--SSB-CCCSCCCEEEE-CCEECCTTC--SEEE----EEBCEETTEECCEECSSSSCBEECCCCCC-SSCCCEEE- T ss_pred ceee--ece-ecCCCCEEEEe-eeeccCccc--ceee----EEEEEcCCeEEEEEECCCcCcceeecccc-cceeceeE- Confidence 3322 233 67889999764 455444322 1221 999999999988876644332 11222 33333333 Q sp|P0DTC2|SPIK 228 DLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFT 307 (1273) Q Consensus 228 dlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlksft 307 (1273) .+-|+..++ .+.+ ..++|||++|.+|+|||+|++||.||+||||+-|+++|-||..+||. T Consensus 248 ---------------v~~~~~~~~---~~~~--~~~~~~v~~L~~~~~ll~fd~~G~i~~avDC~~~~~~el~C~~~sf~ 307 (1275) T 6VSJ_A 248 ---------------VLPFICNPT---AGST--FAPRYWVTPLVKRQYLFNFNQKGVITSAVDCASSYTSEIKCKTQSML 307 (1275) T ss_dssp ---------------ECCEECCCS---SCSC--CCCEEEEEEEEEEEEECCBCSSSCBCCCBCTTSCHHHHHHHHHTSSS T ss_pred ---------------EeeeeecCC---CCCC--cccEEEEEeccceeEEEEecCCCeEeEEEecccCccceeeeEecccc Confidence 233444333 2223 67899999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 308 VEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKL 387 (1273) Q Consensus 308 vekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl 387 (1273) +++|+|++|+||+||....+|.++.+..|+|.++++|.++.++|.|.|+.++||..|+++|++..++++|+||||+|.|| T Consensus 308 ~~~GVY~~s~y~a~p~~~v~~~~~~~~~C~~~~~~~~~~~P~p~~w~R~~~~nCnfn~s~Ll~~~~~~~f~C~~ispskl 387 (1275) T 6VSJ_A 308 PSTGVYELSGYTVQPVGVVYRRVANLPACNIEEWLTARSVPSPLNWERKTFQNCNFNLSSLLRYVQAESLFCNNIDASKV 387 (1275) T ss_dssp CCSSCEECCCCCCCCCCCCCCCCCCCCBCCTHHHHTCSEEECTTSCEEEEECSCBCCHHHHHHHSEEEECCBSSCCTTTS T ss_pred CCCceeecCCeEEEeeeEEEEecCCCCCCCHHHHHhcCCCCCchhcEEeEEecCCCCHHHHHhheeeccceecCCCHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 388 NDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSK----VGGNYNYLYRLFRKSNLKP 463 (1273) Q Consensus 388 ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldsk----vggnynylyrlfrksnlkp 463 (1273) .++||..|++|.|.|..+..++++||++|-|++||||+|+||+||+++|+-...+.. --++||+-|+.-++..++| T Consensus 388 ~~~CfssvtiD~F~ip~~~~~~l~~g~~g~i~~yNYkl~~~~~~C~l~~~~~~~~~~~t~~np~~~~~~~~~~~~~~f~~ 467 (1275) T 6VSJ_A 388 YGRCFGSISVDKFAVPRSRQVDLQLGNSGFLQTANYKIDTAATSCQLHYTLPKNNVTINNHNPSSWNRRYGFNDAGVFGK 467 (1275) T ss_dssp TTCCBSEEEEEEECCCSTTGGGGSTTCCSSHHHHTCCCCSSSCEEECEEEECTTTCEEECCCCCHHHHHHSCCTTTTTTT T ss_pred cccccCeeEEEEEeccchhceeecCCCCcHhHhccccCCCCCCceEEEEEcCcccccccCCCCccchhcccccccccccC Confidence 999999999999999999999999999999999999999999999999996543322 2357888888888899999 Q sp|P0DTC2|SPIK 464 FERDISTEIY--QAGSTPCNG--V------------------EGFNCYF------------PLQSYGFQPTNGVGYQPY- 508 (1273) Q Consensus 464 ferdisteiy--qagstpcng--v------------------egfncyf------------plqsygfqptngvgyqpy- 508 (1273) +++|..-..+ ..+.+-|+. . .|..|+- |..+---+|+..+||+++ T Consensus 468 ~~~dvvy~~~~~~~~~~~cpC~~~~~~~~ct~~~~~~~~~~~~~~~c~g~~vi~~~~g~~~~~~~c~c~~~af~gws~d~ 547 (1275) T 6VSJ_A 468 NQHDVVYAQQCFTVRSSFCPCAQPDIVSPCTTQTKPKSAFVNVGDHCEGLGVLEDNCGNADPHKGCICANNSFIGWSHDT 547 (1275) T ss_dssp CSSEEEEESCBBCCCSCCCSCC-----------CCCCBCCCCTTCCCCCBEECTTSEECCCSSSSCEECTTCEESEEEEE T ss_pred cccceeeccccccCCCCCCCCCCCCcCCCCCCCCCCccceeccccccceeEEeeccCCCCCCCCCccccCCcccccCccc Confidence 9999876533 233333330 0 1112211 001111256777888888 Q sp|P0DTC2|SPIK 509 -----RVVVLSFELLHA--PATVCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTESN-KKFLPFQQFGRDIADTTDAVR 577 (1273) Q Consensus 509 -----rvvvlsfellha--patvcgp---kkstnlvknkcvnfnfngltgtgvltesn-kkflpfqqfgrdiadttdavr 577 (1273) |++|+|++||++ ++|||+. +..++++.++||++|..|.||+||+++.+ ..+-.+|.+..+.+.-..++| T Consensus 548 c~~~~r~~i~~~~~ln~~~s~tvCp~~~~~~~t~I~ln~CVdYNIYGitGtGVItnvt~~~~~~~qgL~yS~sG~L~~FK 627 (1275) T 6VSJ_A 548 CLVNDRCQIFANILLNGINSGTTCSTDLQLPNTEVVTGICVKYDLYGITGQGVFKEVKADYYNSWQTLLYDVNGNLNGFR 627 (1275) T ss_dssp CEETTEEEEEEEEEEESTTCCSBBCSSSCCCCCCCCCSSCEEEEETTEEEEEEEECCCCCCCCSSCCCEECTTSCEEEEE T ss_pred cccCCceeeeeeeeccCCCCCCCCCCcCCCCCceEEeCeEEEEEeCCCeeEEEEEecCCcccccCccEEEeCCCCEEEEE Confidence 999999999998 8999998 34689999999999999999999999944 444466778888889999999 Q sp|P0DTC2|SPIK 578 DPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVN 657 (1273) Q Consensus 578 dpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvn 657 (1273) ++.++++..|+||..+.++++..|. +...|+++..++|+++....+....+| .+.|+|-.||+++++|.+ T Consensus 628 n~ttg~~YsV~PC~~v~qQvVV~~~--sivgalls~n~~cs~~~~n~~~~~~~~--------~~~~~t~~gCv~~a~~~t 697 (1275) T 6VSJ_A 628 DLTTNKTYTIRSCYSGRVSAAFHKD--APEPALLYRNINCSYVFSNNISREENP--------LNYFDSYLGCVVNADNRT 697 (1275) T ss_dssp CTTTCCEEEEECCCCCEEECCCCTT--CSSCCEEETTCCHHHHHHTTCCSSCCC--------SCCEECSSSEECSCSEEE T ss_pred cCCCCCEEEEEeCceeceeEEEeCC--CceeEEEEeccceeceeeccceeeeCC--------CcceeccccceeccccCC Confidence 9999999999999999999999876 567789999999999886444333333 344999999999999887 Q sp|P0DTC2|SPIK 658 N--SYECDIPIGAGICASYQTQTNSPRRARSVASQ-SIIA---YT-MSLGAENSVAYSNNSIAIPTNFTISVTTEILPVS 730 (1273) Q Consensus 658 n--syecdipigagicasyqtqtnsprrarsvasq-siia---yt-mslgaensvaysnnsiaiptnftisvtteilpvs 730 (1273) + ..+|++|.|.|||+.+..-.-.+ |++..+ .+.. +. +..........+...|.||+||||+|++|-++++ T Consensus 698 ~~~~~~c~~~~g~giC~dg~~~~~~~---~~~~~~~~~~~~~~~~~~~~~~s~~~~~~~~~i~IP~nFtlsv~~EyiQt~ 774 (1275) T 6VSJ_A 698 DEALPNCDLRMGAGLCVDYSKSRRAH---RSVSTGYRLTTFEPYTPMLVNDSVQSVDGLYEMQIPTNFTIGHHEEFIQTR 774 (1275) T ss_dssp EEEESSCSEEETTTEEEEECTTTCSS---SSSTTSEEEEEECSCCCCBCCCSCSSSCCBCSCCBCCCCEEECCEEECCCC T ss_pred CCcCCCCCCccceEEccCcccceecc---cccCCCceeecccCCcccccCCCCCccCcceEEEccCceEEEEEEEEeecC Confidence 5 68999999999999998833222 221111 1111 11 1111125566777899999999999999999999 Q sp|P0DTC2|SPIK 731 MTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTP-P----I-KDFGGFNFSQ 804 (1273) Q Consensus 731 mtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktp-p----i-kdfggfnfsq 804 (1273) |.|.+|||.+|+||++.+|.+||.|||+||..+|+||.|.+..+|....++++.+++.++.+ + | ...|+|||+. T Consensus 775 ~~kVsIDCa~YVC~g~~rC~~LL~QYgsfC~~I~~aL~~~~~~~d~~~~~~~~~~~~~~~~s~~~~~~~~~~~~~fN~s~ 854 (1275) T 6VSJ_A 775 SPKVTIDCAAFVCGDNTACRQQLVEYGSFCVNVNAILNEVNNLLDNMQLQVASALMQGVTISSRLPDGISGPIDDINFSP 854 (1275) T ss_dssp CCEEECCHHHHHSCSSHHHHHHHGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCBCC---------------- T ss_pred CCCeEEEhhheecCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccccccCCCCCCCCCCCccchh Confidence 99999999999999999999999999999999999999999999999999999999998875 2 2 4456799999 Q sp|P0DTC2|SPIK 805 ILPD-----------PSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQY 873 (1273) Q Consensus 805 ilpd-----------pskpskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqy 873 (1273) +||. |+++++||+|||||||||+.+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++||+|.| T Consensus 855 ll~~~~~~~~~~~~~~~~~~~RSaIEDLLF~KV~t~glG~~~~Yk~Ct~g~~i~DL~CAQyyNGImVLPpvvd~~~~amY 934 (1275) T 6VSJ_A 855 LLGCIGSTCAEDGNGPSAIRGRSAIEDLLFDKVKLSDVGFVEAYNNCTGGQEVRDLLCVQSFNGIKVLPPVLSESQISGY 934 (1275) T ss_dssp ------CCSSCCSSSTTTTTTTTHHHHHHHHHCSSCTTHHHHHHHHHHTTSSTTSSHHHHHHTTCEEECCSSCHHHHHHH T ss_pred hcccccCCcccCCCCCCccCcccHHHHHHcceeeecCCchHHHHHhccCCcchHHhhcccccCcEEEeCCCCCHHHHHHH Confidence 9986 56668999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 874 TSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVN 953 (1273) Q Consensus 874 tsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvn 953 (1273) |++|++|....|||+ |..||||+||.||+||+|+||+||.||||+|||.||.||+.||+.++++++||.|+||||| T Consensus 935 TasL~g~m~~gg~Ta----aaaIPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~iq~~f~~~~~Al~kiQ~VVN 1010 (1275) T 6VSJ_A 935 TTGATAAAMFPPWSA----AAGVPFSLSVQYRINGLGVTMNVLSENQKMIASAFNNALGAIQDGFDATNSALGKIQSVVN 1010 (1275) T ss_dssp HHHHHHTTSCSSSCS----STTCCHHHHHHHHGGGTSCHHHHTTHHHHHHHHHHHHHHHHHHHHHSSCCHHHHHHHHHHH T ss_pred HHHHHHHhhcccchh----cccCchHHHHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 999999999999997 5568999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 954 QNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECV 1033 (1273) Q Consensus 954 qnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecv 1033 (1273) ++++||++|++||+.|||||||.++||++|||++||++||||||+|||.+|++||+|||+|++|+|||+.||..||.||| T Consensus 1011 ~q~~aL~~L~~qL~~nFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtQ~L~~~~evr~sr~LA~qKINECV 1090 (1275) T 6VSJ_A 1011 ANAEALNNLLNQLSNRFGAISASLQEILTRLEAVEAKAQIDRLINGRLTALNAYISKQLSDSTLIKVSAAQAIEKVNECV 1090 (1275) T ss_dssp HHHHHHHHHHHGGGSCCSSSCSCHHHHHHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC T ss_pred HHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1034 LGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQRNFYEP 1112 (1273) Q Consensus 1034 lgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqrnfyep 1112 (1273) ..||+|.+|||.|.|++|+||.||+|++|+|++|+|.+.++.+++|.+|+++ ++..|+.|+|+.+...|++|.|++||| T Consensus 1091 KSQS~R~gFCGnGtHi~Si~q~APnGi~FlH~~y~Pt~~~~V~a~~GlC~~~~~~~~p~~g~fv~~n~~~~iT~r~~Y~P 1170 (1275) T 6VSJ_A 1091 KSQTTRINFCGNGNHILSLVQNAPYGLYFIHFSYVPISFTTANVSPGLCISGDRGLAPKAGYFVQDDGEWKFTGSSYYYP 1170 (1275) T ss_dssp CSCCSSSSCSSSSCCCCCCEECCTTSCEEECCEEECCSCCCCBCCTTCCSCCCSSSCCCCSCCCBCSSSSBCCCSSBCCC T ss_pred hcCCCcccccCCCeEEEEeeeccCCeEEEEEEEecccceEEEEEEeeeEecCCceEEecCeEEEecCCEEEEeccCcccC Confidence 9999999999999999999999999999999999999999999999999994 899999999999988999999999999 Q sp|P0DTC2|SPIK 1113 QIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLG-DISGINASVVN----IQKEIDRLN 1187 (1273) Q Consensus 1113 qiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlg-disginasvvn----iqkeidrln 1187 (1273) ..||.+|...-..|||...-+|+++..|..|++..|+|||+|+|||+++...|++ |++.+|+++++ ++.++++|+ T Consensus 1171 r~it~~d~v~~~sC~v~y~n~~~~~l~~~~p~~~df~~el~~~~~n~~~~~p~~~~~~~~~N~t~L~Ei~~l~~~~~~l~ 1250 (1275) T 6VSJ_A 1171 EPITDKNSVIMSSCAVNYTKAPEVFLNTSIPNPPDFKEELDKWFKNQTSIAPDLSLDFEKLNVTLIKRMKQIEDKIEEIE 1250 (1275) T ss_dssp CSSCCC-------------------------------------------------------------------------- T ss_pred CCCCccceEEeeccccEEEEcccccCCCCCCCCCChHHHHHHHHhcCCCCCCCcCCCHHHccHHHHHHHHHHHHHHHHHH Confidence 9999999999999999999999999999999999999999999999999666664 38899999986 666666666 Q sp|P0DTC2|SPIK 1188 EVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1188 evaknlneslidlqelg 1204 (1273) ++.++||.++.++..+. T Consensus 1251 ~~i~~in~~~~~~~~~~ 1267 (1275) T 6VSJ_A 1251 SKQKKIENEIARIKKIK 1267 (1275) T ss_dssp ----------------- T ss_pred HHHHHHHHHHHHHHHhc Confidence 66777777766665543 No 7 >6VSJ_C Spike glycoprotein, Carcinoembryonic antigen-related cell; MHV spike, CEACAM1a, Complex, Glycoprotein; HET: NAG; 3.94A {Murine coronavirus (strain A59)} Probab=100.00 E-value=2.1e-195 Score=1649.54 Aligned_cols=1145 Identities=30% Similarity=0.512 Sum_probs=889.4 Template_Neff=4.000 Q sp|P0DTC2|SPIK 9 PLVSSQCVNLTTRTQLP---PAYT-----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAI--HVSGTNGTKR 78 (1273) Q Consensus 9 plvssqcvnlttrtqlp---payt-----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhai--hvsgtngtkr 78 (1273) ++....|...-...-++ |.++ -+-.+|+||||..++|+..+-.|+||.+.-++.+-+-.- |... .--. T Consensus 22 ~i~~~~C~~~~~~~~~~~~~~~~s~~~idvs~~~G~yYPd~rvysN~TlL~qGLFP~~gs~~~~Y~~sgt~~~s--~~~~ 99 (1275) T 6VSJ_C 22 YIGDFRCIQLVNSNGANVSAPSISTETVEVSQGLGTYYVLDRVYLNATLLLTGYYPVDGSKFRNLALRGTNSVS--LSWF 99 (1275) T ss_dssp CCSSBCCCCCSEECCCCCCCCCCCSCBCCCTTSTTCBCCTTCBCCSCCCEEEEEEECTTCBCCBCCCEESSEEC--GGGS T ss_pred cccCcceeEeecCCCCCCCCCCCcceeeeeecceeEEEeCCeEEeceeeeeccccCCCCCceeeEEeeccCCCC--cccc Confidence 34555677653333333 3444 345689999999999999999999999998887654222 2222 1346 Q sp|P0DTC2|SPIK 79 FDNPVLPFNDGVYFASTEKSNI--------IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNK 150 (1273) Q Consensus 79 fdnpvlpfndgvyfasteksni--------irgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnk 150 (1273) +++++.||+||+++...+.+|- -..++||+|.+..+++++|+++-+...|.+|.|..|..|...+++.-+|. T Consensus 100 y~~~~~~F~dGIfVkV~~~kn~t~~~~~~~ypa~~fGSTF~Nts~tvVI~P~~~~r~itvCq~~vC~~p~~~~~p~~g~~ 179 (1275) T 6VSJ_C 100 QPPYLNQFNDGIFAKVQNLKTSTPSGATAYFPTIVIGSLFGYTSYTVVIEPYNGVIMASVCQYTICQLPYTDCKPNTNGN 179 (1275) T ss_dssp STTTSCCCSSCEEEEEECCGGGSCTTCCCSSCCEEEESSCSTTSCEEEECEETTEECCEEECCCBBSSCCEESSCCCSSC T ss_pred cCCcccccCCcEEEEeeeeccCCCCcchhccceeEEecccCCCceEEEEeCCCceeEeEEEEEEEcCCCeeEEccCCCCC Confidence 7788999999999998887765 35678999999999999999999999999999999999999888744332 Q sp|P0DTC2|SPIK 151 SWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLV 227 (1273) Q Consensus 151 swmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplv 227 (1273) +..+ ++. ....+|+|.|. +.|-+|... ..|- |.|+..||.|-+|..+...+. ..-+| |...+.+. T Consensus 180 ~~~~--~~~-~d~~nc~f~~~-~nfT~d~~~--~~~~----~~F~~~dG~fy~Yyad~~~~~~f~f~~~~-~~~~~~yy- 247 (1275) T 6VSJ_C 180 KLIG--FWH-TDVKPPICVLK-RNFTLNVNA--DAFY----FHFYQHGGTFYAYYADKPSATTFLFSVYI-GDILTQYY- 247 (1275) T ss_dssp TTCC--SSB-CCCSCCCEEEE-CCEECCTTC--SEEE----EEBCEETTEECCEECSSSSCBEECCCCCC-SSCCCEEE- T ss_pred ceee--ece-ecCCCCEEEEe-eeeccCccc--ceee----EEEEEcCCeEEEEEECCCcCcceeecccc-cceeceeE- Confidence 3322 233 67889999764 455444322 1221 999999999988876644332 11222 33333333 Q sp|P0DTC2|SPIK 228 DLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFT 307 (1273) Q Consensus 228 dlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlksft 307 (1273) .+-|+..++ .+.+ ..++|||++|.+|+|||+|++||.||+||||+-|+++|-||..+||. T Consensus 248 ---------------v~~~~~~~~---~~~~--~~~~~~v~~L~~~~~ll~fd~~G~i~~avDC~~~~~~el~C~~~sf~ 307 (1275) T 6VSJ_C 248 ---------------VLPFICNPT---AGST--FAPRYWVTPLVKRQYLFNFNQKGVITSAVDCASSYTSEIKCKTQSML 307 (1275) T ss_dssp ---------------ECCEECCCS---SCSC--CCCEEEEEEEEEEEEECCBCSSSCBCCCBCTTSCHHHHHHHHHTSSS T ss_pred ---------------EeeeeecCC---CCCC--cccEEEEEeccceeEEEEecCCCeEeEEEecccCccceeeeEecccc Confidence 233444333 2223 67899999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 308 VEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKL 387 (1273) Q Consensus 308 vekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl 387 (1273) +++|+|++|+||+||....+|.++.+..|+|.++++|.++.++|.|.|+.++||..|+++|++..++++|+||||+|.|| T Consensus 308 ~~~GVY~~s~y~a~p~~~v~~~~~~~~~C~~~~~~~~~~~P~p~~w~R~~~~nCnfn~s~Ll~~~~~~~f~C~~ispskl 387 (1275) T 6VSJ_C 308 PSTGVYELSGYTVQPVGVVYRRVANLPACNIEEWLTARSVPSPLNWERKTFQNCNFNLSSLLRYVQAESLFCNNIDASKV 387 (1275) T ss_dssp CCSSCEECCCCCCCCCCCCCCCCCCCCBCCTHHHHTCSEEECTTSCEEEEECSCBCCHHHHHHHSEEEECCBSSCCTTTS T ss_pred CCCceeecCCeEEEeeeEEEEecCCCCCCCHHHHHhcCCCCCchhcEEeEEecCCCCHHHHHhheeeccceecCCCHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 388 NDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSK----VGGNYNYLYRLFRKSNLKP 463 (1273) Q Consensus 388 ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldsk----vggnynylyrlfrksnlkp 463 (1273) .++||..|++|.|.|..+..++++||++|-|++||||+|+||+||+++|+-...+.. --++||+-|+.-++..++| T Consensus 388 ~~~CfssvtiD~F~ip~~~~~~l~~g~~g~i~~yNYkl~~~~~~C~l~~~~~~~~~~~t~~np~~~~~~~~~~~~~~f~~ 467 (1275) T 6VSJ_C 388 YGRCFGSISVDKFAVPRSRQVDLQLGNSGFLQTANYKIDTAATSCQLHYTLPKNNVTINNHNPSSWNRRYGFNDAGVFGK 467 (1275) T ss_dssp TTCCBSEEEEEEECCCSTTGGGGSTTCCSSHHHHTCCCCSSSCEEECEEEECTTTCEEECCCCCHHHHHHSCCTTTTTTT T ss_pred cccccCeeEEEEEeccchhceeecCCCCcHhHhccccCCCCCCceEEEEEcCcccccccCCCCccchhcccccccccccC Confidence 999999999999999999999999999999999999999999999999996543322 2357888888888899999 Q sp|P0DTC2|SPIK 464 FERDISTEIY--QAGSTPCNG--V------------------EGFNCYF------------PLQSYGFQPTNGVGYQPY- 508 (1273) Q Consensus 464 ferdisteiy--qagstpcng--v------------------egfncyf------------plqsygfqptngvgyqpy- 508 (1273) +++|..-..+ ..+.+-|+. . .|..|+- |..+---+|+..+||+++ T Consensus 468 ~~~dvvy~~~~~~~~~~~cpC~~~~~~~~ct~~~~~~~~~~~~~~~c~g~~vi~~~~g~~~~~~~c~c~~~af~gws~d~ 547 (1275) T 6VSJ_C 468 NQHDVVYAQQCFTVRSSFCPCAQPDIVSPCTTQTKPKSAFVNVGDHCEGLGVLEDNCGNADPHKGCICANNSFIGWSHDT 547 (1275) T ss_dssp CSSEEEEESCBBCCCSCCCSCC-----------CCCCBCCCCTTCCCCCBEECTTSEECCCSSSSCEECTTCEESEEEEE T ss_pred cccceeeccccccCCCCCCCCCCCCcCCCCCCCCCCccceeccccccceeEEeeccCCCCCCCCCccccCCcccccCccc Confidence 9999876533 233333330 0 1112211 001111256777888888 Q sp|P0DTC2|SPIK 509 -----RVVVLSFELLHA--PATVCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTESN-KKFLPFQQFGRDIADTTDAVR 577 (1273) Q Consensus 509 -----rvvvlsfellha--patvcgp---kkstnlvknkcvnfnfngltgtgvltesn-kkflpfqqfgrdiadttdavr 577 (1273) |++|+|++||++ ++|||+. +..++++.++||++|..|.||+||+++.+ ..+-.+|.+..+.+.-..++| T Consensus 548 c~~~~r~~i~~~~~ln~~~s~tvCp~~~~~~~t~I~ln~CVdYNIYGitGtGVItnvt~~~~~~~qgL~yS~sG~L~~FK 627 (1275) T 6VSJ_C 548 CLVNDRCQIFANILLNGINSGTTCSTDLQLPNTEVVTGICVKYDLYGITGQGVFKEVKADYYNSWQTLLYDVNGNLNGFR 627 (1275) T ss_dssp CEETTEEEEEEEEEEESTTCCSBBCSSSCCCCCCCCCSSCEEEEETTEEEEEEEECCCCCCCCSSCCCEECTTSCEEEEE T ss_pred cccCCceeeeeeeeccCCCCCCCCCCcCCCCCceEEeCeEEEEEeCCCeeEEEEEecCCcccccCccEEEeCCCCEEEEE Confidence 999999999998 8999998 34689999999999999999999999944 444466778888889999999 Q sp|P0DTC2|SPIK 578 DPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVN 657 (1273) Q Consensus 578 dpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvn 657 (1273) ++.++++..|+||..+.++++..|. +...|+++..++|+++....+....+| .+.|+|-.||+++++|.+ T Consensus 628 n~ttg~~YsV~PC~~v~qQvVV~~~--sivgalls~n~~cs~~~~n~~~~~~~~--------~~~~~t~~gCv~~a~~~t 697 (1275) T 6VSJ_C 628 DLTTNKTYTIRSCYSGRVSAAFHKD--APEPALLYRNINCSYVFSNNISREENP--------LNYFDSYLGCVVNADNRT 697 (1275) T ss_dssp CTTTCCEEEEECCCCCEEECCCCTT--CSSCCEEETTCCHHHHHHTTCCSSCCC--------SCCEECSSSEECSCSEEE T ss_pred cCCCCCEEEEEeCceeceeEEEeCC--CceeEEEEeccceeceeeccceeeeCC--------CcceeccccceeccccCC Confidence 9999999999999999999999876 567789999999999886444333333 344999999999999887 Q sp|P0DTC2|SPIK 658 N--SYECDIPIGAGICASYQTQTNSPRRARSVASQ-SIIA---YT-MSLGAENSVAYSNNSIAIPTNFTISVTTEILPVS 730 (1273) Q Consensus 658 n--syecdipigagicasyqtqtnsprrarsvasq-siia---yt-mslgaensvaysnnsiaiptnftisvtteilpvs 730 (1273) + ..+|++|.|.|||+.+..-.-.+ |++..+ .+.. +. +..........+...|.||+||||+|++|-++++ T Consensus 698 ~~~~~~c~~~~g~giC~dg~~~~~~~---~~~~~~~~~~~~~~~~~~~~~~s~~~~~~~~~i~IP~nFtlsv~~EyiQt~ 774 (1275) T 6VSJ_C 698 DEALPNCDLRMGAGLCVDYSKSRRAH---RSVSTGYRLTTFEPYTPMLVNDSVQSVDGLYEMQIPTNFTIGHHEEFIQTR 774 (1275) T ss_dssp EEEESSCSEEETTTEEEEECTTTCSS---SSSTTSEEEEEECSCCCCBCCCSCSSSCCBCSCCBCCCCEEECCEEECCCC T ss_pred CCcCCCCCCccceEEccCcccceecc---cccCCCceeecccCCcccccCCCCCccCcceEEEccCceEEEEEEEEeecC Confidence 5 68999999999999998833222 221111 1111 11 1111125566777899999999999999999999 Q sp|P0DTC2|SPIK 731 MTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTP-P----I-KDFGGFNFSQ 804 (1273) Q Consensus 731 mtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktp-p----i-kdfggfnfsq 804 (1273) |.|.+|||.+|+||++.+|.+||.|||+||..+|+||.|.+..+|....++++.+++.++.+ + | ...|+|||+. T Consensus 775 ~~kVsIDCa~YVC~g~~rC~~LL~QYgsfC~~I~~aL~~~~~~~d~~~~~~~~~~~~~~~~s~~~~~~~~~~~~~fN~s~ 854 (1275) T 6VSJ_C 775 SPKVTIDCAAFVCGDNTACRQQLVEYGSFCVNVNAILNEVNNLLDNMQLQVASALMQGVTISSRLPDGISGPIDDINFSP 854 (1275) T ss_dssp CCEEECCHHHHHSCSSHHHHHHHGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCBCC---------------- T ss_pred CCCeEEEhhheecCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccccccCCCCCCCCCCCccchh Confidence 99999999999999999999999999999999999999999999999999999999998875 2 2 4456799999 Q sp|P0DTC2|SPIK 805 ILPD-----------PSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQY 873 (1273) Q Consensus 805 ilpd-----------pskpskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqy 873 (1273) +||. |+++++||+|||||||||+.+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++||+|.| T Consensus 855 ll~~~~~~~~~~~~~~~~~~~RSaIEDLLF~KV~t~glG~~~~Yk~Ct~g~~i~DL~CAQyyNGImVLPpvvd~~~~amY 934 (1275) T 6VSJ_C 855 LLGCIGSTCAEDGNGPSAIRGRSAIEDLLFDKVKLSDVGFVEAYNNCTGGQEVRDLLCVQSFNGIKVLPPVLSESQISGY 934 (1275) T ss_dssp ------CCSSCCSSSTTTTTTTTHHHHHHHHHCSSCTTHHHHHHHHHHTTSSTTSSHHHHHHTTCEEECCSSCHHHHHHH T ss_pred hcccccCCcccCCCCCCccCcccHHHHHHcceeeecCCchHHHHHhccCCcchHHhhcccccCcEEEeCCCCCHHHHHHH Confidence 9986 56668999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 874 TSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVN 953 (1273) Q Consensus 874 tsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvn 953 (1273) |++|++|....|||+ |..||||+||.||+||+|+||+||.||||+|||.||.||+.||+.++++++||.|+||||| T Consensus 935 TasL~g~m~~gg~Ta----aaaIPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~iq~~f~~~~~Al~kiQ~VVN 1010 (1275) T 6VSJ_C 935 TTGATAAAMFPPWSA----AAGVPFSLSVQYRINGLGVTMNVLSENQKMIASAFNNALGAIQDGFDATNSALGKIQSVVN 1010 (1275) T ss_dssp HHHHHHTTSCSSSCS----STTCCHHHHHHHHGGGTSCHHHHTTHHHHHHHHHHHHHHHHHHHHHSSCCHHHHHHHHHHH T ss_pred HHHHHHHhhcccchh----cccCchHHHHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 999999999999997 5568999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 954 QNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECV 1033 (1273) Q Consensus 954 qnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecv 1033 (1273) ++++||++|++||+.|||||||.++||++|||++||++||||||+|||.+|++||+|||+|++|+|||+.||..||.||| T Consensus 1011 ~q~~aL~~L~~qL~~nFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtQ~L~~~~evr~sr~LA~qKINECV 1090 (1275) T 6VSJ_C 1011 ANAEALNNLLNQLSNRFGAISASLQEILTRLEAVEAKAQIDRLINGRLTALNAYISKQLSDSTLIKVSAAQAIEKVNECV 1090 (1275) T ss_dssp HHHHHHHHHHHGGGSCCSSSCSCHHHHHHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC T ss_pred HHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1034 LGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQRNFYEP 1112 (1273) Q Consensus 1034 lgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqrnfyep 1112 (1273) ..||+|.+|||.|.|++|+||.||+|++|+|++|+|.+.++.+++|.+|+++ ++..|+.|+|+.+...|++|.|++||| T Consensus 1091 KSQS~R~gFCGnGtHi~Si~q~APnGi~FlH~~y~Pt~~~~V~a~~GlC~~~~~~~~p~~g~fv~~n~~~~iT~r~~Y~P 1170 (1275) T 6VSJ_C 1091 KSQTTRINFCGNGNHILSLVQNAPYGLYFIHFSYVPISFTTANVSPGLCISGDRGLAPKAGYFVQDDGEWKFTGSSYYYP 1170 (1275) T ss_dssp CSCCSSSSCSSSSCCCCCCEECCTTSCEEECCEEECCSCCCCBCCTTCCSCCCSSSCCCCSCCCBCSSSSBCCCSSBCCC T ss_pred hcCCCcccccCCCeEEEEeeeccCCeEEEEEEEecccceEEEEEEeeeEecCCceEEecCeEEEecCCEEEEeccCcccC Confidence 9999999999999999999999999999999999999999999999999994 899999999999988999999999999 Q sp|P0DTC2|SPIK 1113 QIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLG-DISGINASVVN----IQKEIDRLN 1187 (1273) Q Consensus 1113 qiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlg-disginasvvn----iqkeidrln 1187 (1273) ..||.+|...-..|||...-+|+++..|..|++..|+|||+|+|||+++...|++ |++.+|+++++ ++.++++|+ T Consensus 1171 r~it~~d~v~~~sC~v~y~n~~~~~l~~~~p~~~df~~el~~~~~n~~~~~p~~~~~~~~~N~t~L~Ei~~l~~~~~~l~ 1250 (1275) T 6VSJ_C 1171 EPITDKNSVIMSSCAVNYTKAPEVFLNTSIPNPPDFKEELDKWFKNQTSIAPDLSLDFEKLNVTLIKRMKQIEDKIEEIE 1250 (1275) T ss_dssp CSSCCC-------------------------------------------------------------------------- T ss_pred CCCCccceEEeeccccEEEEcccccCCCCCCCCCChHHHHHHHHhcCCCCCCCcCCCHHHccHHHHHHHHHHHHHHHHHH Confidence 9999999999999999999999999999999999999999999999999666664 38899999986 666666666 Q sp|P0DTC2|SPIK 1188 EVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1188 evaknlneslidlqelg 1204 (1273) ++.++||.++.++..+. T Consensus 1251 ~~i~~in~~~~~~~~~~ 1267 (1275) T 6VSJ_C 1251 SKQKKIENEIARIKKIK 1267 (1275) T ss_dssp ----------------- T ss_pred HHHHHHHHHHHHHHHhc Confidence 66777777766665543 No 8 >6OHW_A Spike surface glycoprotein; Coronavirus spike glycoprotein, sialic acid; HET: MAN, NAG, BMA; 2.9A {Human coronavirus OC43} Probab=100.00 E-value=7.3e-190 Score=1602.12 Aligned_cols=1144 Identities=29% Similarity=0.505 Sum_probs=895.1 Template_Neff=3.700 Q sp|P0DTC2|SPIK 2 FVFLVLLP-----LVSSQCVNLTTRTQLP---PAYT-----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAI 68 (1273) Q Consensus 2 fvflvllp-----lvssqcvnlttrtqlp---payt-----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhai 68 (1273) |+|+.|+| +....|.. ....-+. |.++ -+-.+|+||||..++++..+-.|++|.+.-++.+-.- T Consensus 13 ~~~~~~~~~~~~~i~~~~C~~-~~~~~~~~~~~~~~~~~id~s~~~G~yYp~~rvysN~tll~~glfp~~gs~~~~y~-- 89 (1322) T 6OHW_A 13 YLLGMLVASVLAVIGDLKCTS-DNINDKDTGPPPISTDTVDVTNGLGTYYVLDRVYLNTTLFLNGYYPTSGSTYRNMA-- 89 (1322) T ss_dssp ------------CCSSBCCCC-TTEECCCCCSCCEEEEECCCTTSTTCBCCTEEECCSEEEEEEEEEECTTCEEEECC-- T ss_pred HHHHHHHHHHHHHhcCccccc-cCCCCCCCCCCCCCcceeecccCceeEEecCeEEeeeeeEecceecCCCCceEEee-- Confidence 56666655 33445765 2222222 3333 3456899999999999999999999999877665321 Q sp|P0DTC2|SPIK 69 HVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNIIRGW---------IFGTTLDSKTQSLLIVNNATN----------- 125 (1273) Q Consensus 69 hvsgtng---tkrfdnpvlpfndgvyfasteksniirgw---------ifgttldsktqsllivnnatn----------- 125 (1273) .+|++- --.++++..||+||++....+..|. +|| +||+|.+...++++|.++-.+ T Consensus 90 -~~~t~~~s~~~~y~~~~~~F~dGifvkv~~~~~~-t~~~~~~~yp~~~fGstf~N~s~tvVI~P~~~~~~~~~~~~~~~ 167 (1322) T 6OHW_A 90 -LKGSVLLSRLWFKPPFLSDFINGIFAKVKNTKVI-KDRVMYSEFPAITIGSTFVNTSYSVVVQPRTINSTQDGDNKLQG 167 (1322) T ss_dssp -CEESSCEEGGGGSTTTEEECSSEEEEEEECEEEE-ETTEEEEECCCEEEESSCSTTSCEEEEEEEEEC-------CCEE T ss_pred -eecccccccccccCCccccccCcEEEEEEeeccc-CCCceeeccCceEEeccccCCeeEEEEccCCCCcCccccccccc Confidence 223322 2456777889999997766655544 444 699999999999999987664 Q sp|P0DTC2|SPIK 126 -VVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIY 204 (1273) Q Consensus 126 -vvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiy 204 (1273) ..|.+|.|..|..|...+++.-+| +. -+++. ....+|+|.|. +.|-.|... ..|- |.|++.||.|-+| T Consensus 168 ~~~it~C~~~vC~~p~~~~~~~~gn-~~--~~~~~-~d~~~~~~~~~-~nfT~d~~~--~~~~----f~F~q~~G~fy~Y 236 (1322) T 6OHW_A 168 LLEVSVCQYNMCEYPQTICHPNLGN-HR--KELWH-LDTGVVSCLYK-RNFTYDVNA--DYLY----FHFYQEGGTFYAY 236 (1322) T ss_dssp EEEEEEECCCEEEEEEEECCTTTCC-SS--CCEEE-CCSSCCCEEEE-EEEEECTTC--SEEE----EEEEEETTEEEEE T ss_pred ceEEeeeeeEecCCCeeEEecCCCC-Cc--eeeeE-eecCCceEEEe-eeecccccc--ceee----EEEEEeCCeEEEE Confidence 347899999999999988875444 22 23444 66788998765 455444322 1111 9999999999887 Q sp|P0DTC2|SPIK 205 SKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGT 284 (1273) Q Consensus 205 skhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengt 284 (1273) ..+...+. .| +...+.|...+++- .+-|+..++ ..++|||++|.+|+|||+|++||. T Consensus 237 y~d~~~~~------~f-----~f~~~~~~~~~~yy---v~p~~~~~~---------~~~~~~v~~L~~~~~Ll~fd~~G~ 293 (1322) T 6OHW_A 237 FTDTGVVT------KF-----LFNVYLGMALSHYY---VMPLTCNSK---------LTLEYWVTPLTSRQYLLAFNQDGI 293 (1322) T ss_dssp EESSSSSB------EE-----EEEEECSSCCCEEE---ECCEECSSC---------CCCCEEEEEEEEEEEEEEECTTSC T ss_pred EecCCCCc------ce-----eccccceeccceeE---eceeecCCc---------cceeEEEEeceeeeEEEEecCCCe Confidence 44432221 00 01111122222222 222333332 668999999999999999999999 Q sp|P0DTC2|SPIK 285 ITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVAD 364 (1273) Q Consensus 285 itdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvad 364 (1273) ||+||||+-|+++|-||..+||.+++|+|++|+||+||...++|.+.....|+|.++++|.++.++|.|.|+.++||..| T Consensus 294 It~AvDC~~~~~sEl~C~t~sf~~~tGVY~lS~y~aqp~~~V~~~~~~~~~C~~~~~~~~~~~P~p~~w~R~~f~nCnfn 373 (1322) T 6OHW_A 294 IFNAVDCMSDFMSEIKCKTQSIAPPTGVYELNGYTVQPIADVYRRKPNLPNCNIEAWLNDKSVPSPLNWERKTFSNCNFN 373 (1322) T ss_dssp EEEEEETTSSHHHHHHHHTTCSSCCSEEEEEEEEECCCSEEEEECCSSCCBCCHHHHHTCSEEECSTTCEEEEEESCBBC T ss_pred EeEEEecccCcchhheeeecccCCCCceeecCCeEEEeeeEEEEeCCCCCCCCHHHHhcCCCCCCccceEEeEEecCCCC Confidence 99999999999999999999999999999999999999999999999988999999999999999999999999999999 Q sp|P0DTC2|SPIK 365 YSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSK 444 (1273) Q Consensus 365 ysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldsk 444 (1273) +++|++...+++|+||||+|.||.+.||..|++|.|.|..+..++++||.+|.|++||||+|++|+||+++|+-.+.+.. T Consensus 374 ~s~ll~~~~~~~f~C~~ispskl~~~C~ssvtiD~F~ip~~~~~~l~~g~~g~~~~~NYkl~~~~~~C~l~y~~~~~nvn 453 (1322) T 6OHW_A 374 MSSLMSFIQADSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQSFNYRIDTTATSCQLYYNLPAANVS 453 (1322) T ss_dssp HHHHHHHCEEEEEEEESSCGGGGGGCEEEEEEEEEEECCTTCGGGGSTTCCCHCCCCCCCCCSSSCEEEEEEEEEGGGCE T ss_pred HHHHhhhceeceeeecCCCHHHHcccccceeEEEEEeccCCcceeecCCCCcHHHhcCccCCCCCCceEEEEEccccccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999995554333 Q sp|P0DTC2|SPIK 445 V----GGNYNYLYRLFRKSNLKPFERDI---STEIYQ-----AGSTPCN----------G-------------------- 482 (1273) Q Consensus 445 v----ggnynylyrlfrksnlkpferdi---steiyq-----agstpcn----------g-------------------- 482 (1273) + -++||.-|+.-..+.++|.++.. ...+|. .+.+-|+ + T Consensus 454 ~t~~Nps~wn~ry~f~~~~~~~~~~~~~~~~hdvvYs~~cf~~~~~yCPC~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~ 533 (1322) T 6OHW_A 454 VSRFNPSTWNKRFGFIEDSVFKPRPAGVLTNHDVVYAQHCFKAPKNFCPCKLNGSCVGSGPGKNNGIGTCPAGTNYLTCD 533 (1322) T ss_dssp EECCCCCHHHHHTTCCHHHHSCBTTTSSBCTTEEEEESCCEECCTTCCCCBCC-----------CCBBCCCTTCCCBCC- T ss_pred cccCCccchhhccCcccccccCCCCCCcCCCcceeeeeeeecCCCCcCCCcCCCcccCCCCCCCCCCCcCCCCccccccc Confidence 2 34677777766667777765411 112222 2222121 0 Q sp|P0DTC2|SPIK 483 ----VEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFEL-----------------------------------LHAPAT 523 (1273) Q Consensus 483 ----vegfncyfplqsygfqptngvgyqpyrvvvlsfel-----------------------------------lhapat 523 (1273) ..+..|.-+...+--....|+|+++++++|++++. ...+.| T Consensus 534 ~~~~~~~~~~~~~~~~~q~~~~~gvg~~c~gl~Vi~~k~g~~~C~C~~~af~g~~~~~~~~~~~~~i~~~~~~~~~~s~t 613 (1322) T 6OHW_A 534 NLCTPDPITFTGTYKCPQTKSLVGIGEHCSGLAVKSDYCGGNSCTCRPQAFLGWSADSCLQGDKCNIFANFILHDVNSGL 613 (1322) T ss_dssp ---TTCSSSCCCSSCCSSEECCCCTTCCCCCCEECGGGEEBTTTEECGGGEESEEEEECEETTEEEEEEEEEEEEETSSS T ss_pred cCCCCCCCccccccCCCCceeeeecccccceEEEEecccCCCCccCCCccccCCCcccccCCCccccccceeecCCCCCC Confidence 01122211111111123569999999999999988 667889 Q sp|P0DTC2|SPIK 524 VCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTESN-KKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT 599 (1273) Q Consensus 524 vcgp---kkstnlvknkcvnfnfngltgtgvltesn-kkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvit 599 (1273) ||++ +.+++++.++||++|..|.||+||+++++ ..++.++.+..|-+.-..+++++.++++..|+||..|.++++. T Consensus 614 vC~~d~~~~~snI~Ln~CVdYNIYGitGqGVItn~n~~~~~~~~GL~ydssgdL~gfKn~ttg~~YsV~PC~~g~VVGi~ 693 (1322) T 6OHW_A 614 TCSTDLQKANTDIILGVCVNYDLYGILGQGIFVEVNATYYNSWQNLLYDSNGNLYGFRDYITNRTFMIRSCYSGRVSAAF 693 (1322) T ss_dssp EEBCSSCCCCCCCCBSSEEEEEETTEEEEEEEEEECCCCCCTTEEEEECTTSCEEEEECTTTCCEEEEECCCEEEEEEEE T ss_pred cCCCcccccCceEEeCeeeeEEeCCccceEEEEecCCCceeccCcEEEcCCCCEEEEEcCCCCcEEEEEeCccCcEEEEE Confidence 9998 56799999999999999999999999964 5566778888888888889999999999999999999999998 Q sp|P0DTC2|SPIK 600 PGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVN--NSYECDIPIGAGICASYQTQ 677 (1273) Q Consensus 600 pgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvn--nsyecdipigagicasyqtq 677 (1273) ... ++..+.+|.++.|.+|....|..+++| .+-|+|-.||++++.+.. ...+|++|.|.|+|+.|.+ T Consensus 694 tS~--n~t~a~lF~n~~C~~v~~~~~~~~~~~--------~~~f~t~~Gcv~~a~~~t~~~v~~c~~~~g~~~C~~~~~- 762 (1322) T 6OHW_A 694 HAN--SSEPALLFRNIKCNYVFNNSLTRQLQP--------INYFDSYLGCVVNAYNSTAISVQTCDLTVGSGYCVDYSK- 762 (1322) T ss_dssp CTT--CSSCEEEEETCCHHHHHHTTTTTTCCC--------SCEEECSSEEEESSEEEEEEEESCCSEEEETTEEEEEC-- T ss_pred eCC--CCCccceeccceeceeeecccceeecc--------ccceeccccceecceecCCceeccccccccCceeeecCC- Confidence 765 445789999999999998766655555 233999999999999986 4889999999999999988 Q sp|P0DTC2|SPIK 678 TNSPRRARSVAS--QSIIAYTMSL-----GAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECS 750 (1273) Q Consensus 678 tnsprrarsvas--qsiiaytmsl-----gaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecs 750 (1273) |+++++... ..+..| +.+ ........+...|.||+||||+|++|-++++|.|.+|||.+|+||++.+|. T Consensus 763 ---~~gs~~~~~~~~~l~~~-~p~~~~~v~~~~~~~~~~~~IsIP~NFTlsvt~EyIQt~~~kVsIDCa~YVC~~~~~C~ 838 (1322) T 6OHW_A 763 ---NGGSGGAITTGYRFTNF-EPFTVNSVNDSLEPVGGLYEIQIPSEFTIGNMVEFIQTSSPKVTIDCAAFVCGDYAACK 838 (1322) T ss_dssp -----------CCSEEEEEE-CCCCCEEECCCSSCBTTBEEEEEEEEEEEEEEEEEEECCCCEEEECHHHHHSCSCHHHH T ss_pred ---CCCCCceeccCceeeec-cceeecccccCCCCCcceEEEEecCceeeEEEEEEeeecCCCeEEehhheecCCCHHHH Confidence 444433222 222233 222 111223455568999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 751 NLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKT----PPIKDF--GGFNFSQILPDPS----KPSKRSFIED 820 (1273) Q Consensus 751 nlllqygsfctqlnraltgiaveqdkntqevfaqvkqiykt----ppikdf--ggfnfsqilpdps----kpskrsfied 820 (1273) +||.|||+||..+|+||.+++..+|....+++..+++-++. +.+..| |+||||.+||.+. .+++||+||| T Consensus 839 ~LL~QYgs~C~~I~~aL~~v~~~~d~~~~~~~~~~~~~~~~s~~l~~~~~~~~g~fN~s~ll~~~~s~~~~~~~RSaIED 918 (1322) T 6OHW_A 839 SQLVEYGSFCDNINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSPVLGCLGSECSKASSRSAIED 918 (1322) T ss_dssp HHGGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTCEEEGGGGTCCCCEETTEECTTTCCCCCC----CCSSCHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHhcCccccccccccccCCCCCccccccccCCCCCCCcCccccHHHH Confidence 99999999999999999999999999999999999998876 444445 6899999999875 3578999999 Q sp|P0DTC2|SPIK 821 LLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAM 900 (1273) Q Consensus 821 llfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfam 900 (1273) |||+||..+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++||++.||++|++|....|||+ |..||||+ T Consensus 919 LLFnKV~tsglG~~~~Yk~Ct~g~~i~DL~CAQyyNGImVLPpVvd~~~~amYTaSL~g~m~~gg~Ta----aaaIPFa~ 994 (1322) T 6OHW_A 919 LLFDKVKLSDVGFVEAYNNCTGGAEIRDLICVQSYKGIKVLPPLLSENQFSGYTLAATSASLFPPWTA----AAGVPFYL 994 (1322) T ss_dssp HHHHTCSCSHHHHHHHHTTTTTTSCTTCHHHHHHHTTEEEECCSSCHHHHHHHHHHHHHTTTSSSCGG----GTTCCHHH T ss_pred HHcceeeeCCcchHHHhHhccCCccHHHhhccceeCcEEEeCCCCCHHHHHHHHHHHHHHhhccCchh----cccCcchH Confidence 99999999999999999999999999999999999999999999999999999999999999999997 55689999 Q sp|P0DTC2|SPIK 901 QMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDI 980 (1273) Q Consensus 901 qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndi 980 (1273) ||.||+||+|+||+||.||||+|||.||.||+.||+.++.|++||.|+|||||++++||++|++||+.|||||||.++|| T Consensus 995 ~vq~RlN~v~lt~~VL~~NQk~iA~sFN~Ai~~iq~~f~tt~~AL~KiQ~VVN~q~~aL~~L~~qL~~nFgAISssI~DI 1074 (1322) T 6OHW_A 995 NVQYRINGLGVTMDVLSQNQKLIANAFNNALYAIQEGFDATNSALVKIQAVVNANAEALNNLLQQLSNRFGAISASLQEI 1074 (1322) T ss_dssp HHHHHHHTTTCCHHHHTTCHHHHHHHHHHHHHHHHHTTTSCCHHHHHHHHHHHHHHHHHHHHHGGGGCCTTSSCSCHHHH T ss_pred HHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 981 LSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGV 1060 (1273) Q Consensus 981 lsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgv 1060 (1273) ++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+||.||+|+ T Consensus 1075 y~RLD~LEAdaQVDRLItGRL~aLNafVtQ~L~~~~eVr~sr~LA~qKINECVKSQS~R~gFCGnG~Hi~Si~q~AP~Gi 1154 (1322) T 6OHW_A 1075 LSRLDALEAEAQIDRLINGRLTALNAYVSQQLSDSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGL 1154 (1322) T ss_dssp HHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSCCCSCSSCSTTSSEEEEEEEEETTEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCCCCeeEEEeeeccCCeE Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1061 VFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYD 1139 (1273) Q Consensus 1061 vflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvyd 1139 (1273) +|+|.+|+|.+.++.+++|.+|++| ++..|++|+|+.+...|++|.|++|+|..||.+|...-..|||...-+|+++.. T Consensus 1155 ~F~H~~~~Pt~~~~V~a~~GlC~~~~~~~~~~~g~f~~~n~~~~~T~r~~y~Pr~~t~~d~v~~~sC~v~y~n~~~~~l~ 1234 (1322) T 6OHW_A 1155 YFIHFSYVPTKYVTARVSPGLCIAGDRGIAPKSGYFVNVNNTWMYTGSGYYYPEPITENNVVVMSTCAVNYTKAPYVMLN 1234 (1322) T ss_dssp EEEEEEEEEEEEEEEEEESCEECTTSCEEEESSEEEEEETTEEEEEETTEEEEEECCGGGEEEESSCCTTSEECTTCCCC T ss_pred EEEEeEecccceEEEEEeeeEEecCCeeEEecceEEEeeCCEEEEeccCcccCCCCCccceEEeccceeEEEEcCcccCC Confidence 9999999999999999999999995 899999999999988999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1140 PLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNI-QKEIDRLNEVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1140 plqpeldsfkeeldkyfknhtspdvdlgdisginasvvni-qkeidrlnevaknlneslidlqelg 1204 (1273) |..|++..|+|||+|+|||+++...|+.. .-+|++++|+ ++||++|++++|+|+..-.+||.+- T Consensus 1235 ~~~p~~~df~~el~~~~~n~~~~~p~~~~-~~~N~t~Lnlt~~Ei~~L~~~~~~L~~~~~el~~~I 1299 (1322) T 6OHW_A 1235 TSIPNLPDFKEELDQWFKNQTSVAPDLSL-DYINVTFLDLLIKRMKQIEDKIEEIESKQKKIENEI 1299 (1322) T ss_dssp ------------------------------------------------------------------ T ss_pred CCCCCCCChHHHHHHHHhcCCCCCCCCCc-cccccceecccHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999985555543 2299999999 6999999999999999888887654 No 9 >6NZK_A Spike surface glycoprotein; Coronavirus spike glycoprotein, sialic acid; HET: MJJ, MAN, NAG, BMA; 2.8A {Human coronavirus OC43} Probab=100.00 E-value=7.3e-190 Score=1602.12 Aligned_cols=1144 Identities=29% Similarity=0.505 Sum_probs=895.1 Template_Neff=3.700 Q sp|P0DTC2|SPIK 2 FVFLVLLP-----LVSSQCVNLTTRTQLP---PAYT-----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAI 68 (1273) Q Consensus 2 fvflvllp-----lvssqcvnlttrtqlp---payt-----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhai 68 (1273) |+|+.|+| +....|.. ....-+. |.++ -+-.+|+||||..++++..+-.|++|.+.-++.+-.- T Consensus 13 ~~~~~~~~~~~~~i~~~~C~~-~~~~~~~~~~~~~~~~~id~s~~~G~yYp~~rvysN~tll~~glfp~~gs~~~~y~-- 89 (1322) T 6NZK_A 13 YLLGMLVASVLAVIGDLKCTS-DNINDKDTGPPPISTDTVDVTNGLGTYYVLDRVYLNTTLFLNGYYPTSGSTYRNMA-- 89 (1322) T ss_dssp ------------CCSSBCCCC-TTEECCCCCSCCBCSSCCCCTTSTTCBCCTEEECCSEEEEEEEEECCTTCCCEECC-- T ss_pred HHHHHHHHHHHHHhcCccccc-cCCCCCCCCCCCCCcceeecccCceeEEecCeEEeeeeeEecceecCCCCceEEee-- Confidence 56666655 33445765 2222222 3333 3456899999999999999999999999877665321 Q sp|P0DTC2|SPIK 69 HVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNIIRGW---------IFGTTLDSKTQSLLIVNNATN----------- 125 (1273) Q Consensus 69 hvsgtng---tkrfdnpvlpfndgvyfasteksniirgw---------ifgttldsktqsllivnnatn----------- 125 (1273) .+|++- --.++++..||+||++....+..|. +|| +||+|.+...++++|.++-.+ T Consensus 90 -~~~t~~~s~~~~y~~~~~~F~dGifvkv~~~~~~-t~~~~~~~yp~~~fGstf~N~s~tvVI~P~~~~~~~~~~~~~~~ 167 (1322) T 6NZK_A 90 -LKGSVLLSRLWFKPPFLSDFINGIFAKVKNTKVI-KDRVMYSEFPAITIGSTFVNTSYSVVVQPRTINSTQDGDNKLQG 167 (1322) T ss_dssp -CEESSCEEGGGGSTTTEEECSSEEEEEEECEEEE-ETTEEEEECCCEEEESSCSTTSCEEEEEEEEEC-------CCEE T ss_pred -eecccccccccccCCccccccCcEEEEEEeeccc-CCCceeeccCceEEeccccCCeeEEEEccCCCCcCccccccccc Confidence 223322 2456777889999997766655544 444 699999999999999987664 Q sp|P0DTC2|SPIK 126 -VVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIY 204 (1273) Q Consensus 126 -vvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiy 204 (1273) ..|.+|.|..|..|...+++.-+| +. -+++. ....+|+|.|. +.|-.|... ..|- |.|++.||.|-+| T Consensus 168 ~~~it~C~~~vC~~p~~~~~~~~gn-~~--~~~~~-~d~~~~~~~~~-~nfT~d~~~--~~~~----f~F~q~~G~fy~Y 236 (1322) T 6NZK_A 168 LLEVSVCQYNMCEYPQTICHPNLGN-HR--KELWH-LDTGVVSCLYK-RNFTYDVNA--DYLY----FHFYQEGGTFYAY 236 (1322) T ss_dssp EEEEEEECCCEEEEEEEECCTTTCC-SS--CCEEE-CCSSCCCEEEE-EEEEECTTC--SEEE----EEEEEETTEEEEE T ss_pred ceEEeeeeeEecCCCeeEEecCCCC-Cc--eeeeE-eecCCceEEEe-eeecccccc--ceee----EEEEEeCCeEEEE Confidence 347899999999999988875444 22 23444 66788998765 455444322 1111 9999999999887 Q sp|P0DTC2|SPIK 205 SKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGT 284 (1273) Q Consensus 205 skhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengt 284 (1273) ..+...+. .| +...+.|...+++- .+-|+..++ ..++|||++|.+|+|||+|++||. T Consensus 237 y~d~~~~~------~f-----~f~~~~~~~~~~yy---v~p~~~~~~---------~~~~~~v~~L~~~~~Ll~fd~~G~ 293 (1322) T 6NZK_A 237 FTDTGVVT------KF-----LFNVYLGMALSHYY---VMPLTCNSK---------LTLEYWVTPLTSRQYLLAFNQDGI 293 (1322) T ss_dssp EESSSSSB------EE-----EEEEECSSCCCEEE---ECCEECSSC---------CCCCEEEEECEEEEEEEEECTTSC T ss_pred EecCCCCc------ce-----eccccceeccceeE---eceeecCCc---------cceeEEEEeceeeeEEEEecCCCe Confidence 44432221 00 01111122222222 222333332 668999999999999999999999 Q sp|P0DTC2|SPIK 285 ITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVAD 364 (1273) Q Consensus 285 itdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvad 364 (1273) ||+||||+-|+++|-||..+||.+++|+|++|+||+||...++|.+.....|+|.++++|.++.++|.|.|+.++||..| T Consensus 294 It~AvDC~~~~~sEl~C~t~sf~~~tGVY~lS~y~aqp~~~V~~~~~~~~~C~~~~~~~~~~~P~p~~w~R~~f~nCnfn 373 (1322) T 6NZK_A 294 IFNAVDCMSDFMSEIKCKTQSIAPPTGVYELNGYTVQPIADVYRRKPNLPNCNIEAWLNDKSVPSPLNWERKTFSNCNFN 373 (1322) T ss_dssp EEEEEETTSSHHHHHHHHTTCSSCCSEEEECCCEECCCSEEEEECCSSCCBCCHHHHHTCSEEECSTTCEEEEEESCEEC T ss_pred EeEEEecccCcchhheeeecccCCCCceeecCCeEEEeeeEEEEeCCCCCCCCHHHHhcCCCCCCccceEEeEEecCCCC Confidence 99999999999999999999999999999999999999999999999988999999999999999999999999999999 Q sp|P0DTC2|SPIK 365 YSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSK 444 (1273) Q Consensus 365 ysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldsk 444 (1273) +++|++...+++|+||||+|.||.+.||..|++|.|.|..+..++++||.+|.|++||||+|++|+||+++|+-.+.+.. T Consensus 374 ~s~ll~~~~~~~f~C~~ispskl~~~C~ssvtiD~F~ip~~~~~~l~~g~~g~~~~~NYkl~~~~~~C~l~y~~~~~nvn 453 (1322) T 6NZK_A 374 MSSLMSFIQADSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQSFNYRIDTTATSCQLYYNLPAANVS 453 (1322) T ss_dssp HHHHHHHCEEEEEEEESSCGGGGGGCEEEEEEEEEEECCTTCGGGGSTTCCCHCCCCCCCCCSSSCEEEEEEEEEGGGCE T ss_pred HHHHhhhceeceeeecCCCHHHHcccccceeEEEEEeccCCcceeecCCCCcHHHhcCccCCCCCCceEEEEEccccccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999995554333 Q sp|P0DTC2|SPIK 445 V----GGNYNYLYRLFRKSNLKPFERDI---STEIYQ-----AGSTPCN----------G-------------------- 482 (1273) Q Consensus 445 v----ggnynylyrlfrksnlkpferdi---steiyq-----agstpcn----------g-------------------- 482 (1273) + -++||.-|+.-..+.++|.++.. ...+|. .+.+-|+ + T Consensus 454 ~t~~Nps~wn~ry~f~~~~~~~~~~~~~~~~hdvvYs~~cf~~~~~yCPC~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~ 533 (1322) T 6NZK_A 454 VSRFNPSTWNKRFGFIEDSVFKPRPAGVLTNHDVVYAQHCFKAPKNFCPCKLNGSCVGSGPGKNNGIGTCPAGTNYLTCD 533 (1322) T ss_dssp EECCCCCHHHHHTTCCHHHHSCBTTTSSBCTTEEEEESSCEECCTTEEEEECC-----------CCBBCCCTTCEEECC- T ss_pred cccCCccchhhccCcccccccCCCCCCcCCCcceeeeeeeecCCCCcCCCcCCCcccCCCCCCCCCCCcCCCCccccccc Confidence 2 34677777766667777765411 112222 2222121 0 Q sp|P0DTC2|SPIK 483 ----VEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFEL-----------------------------------LHAPAT 523 (1273) Q Consensus 483 ----vegfncyfplqsygfqptngvgyqpyrvvvlsfel-----------------------------------lhapat 523 (1273) ..+..|.-+...+--....|+|+++++++|++++. ...+.| T Consensus 534 ~~~~~~~~~~~~~~~~~q~~~~~gvg~~c~gl~Vi~~k~g~~~C~C~~~af~g~~~~~~~~~~~~~i~~~~~~~~~~s~t 613 (1322) T 6NZK_A 534 NLCTPDPITFTGTYKCPQTKSLVGIGEHCSGLAVKSDYCGGNSCTCRPQAFLGWSADSCLQGDKCNIFANFILHDVNSGL 613 (1322) T ss_dssp ---CSCSSSCCCSSCCSSEECCCCTTCCCCCCEECGGGEEBTTTEECGGGEESEEEEECEETTEEEEEEEEEEEEETSSS T ss_pred cCCCCCCCccccccCCCCceeeeecccccceEEEEecccCCCCccCCCccccCCCcccccCCCccccccceeecCCCCCC Confidence 01122211111111123569999999999999988 667889 Q sp|P0DTC2|SPIK 524 VCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTESN-KKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT 599 (1273) Q Consensus 524 vcgp---kkstnlvknkcvnfnfngltgtgvltesn-kkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvit 599 (1273) ||++ +.+++++.++||++|..|.||+||+++++ ..++.++.+..|-+.-..+++++.++++..|+||..|.++++. T Consensus 614 vC~~d~~~~~snI~Ln~CVdYNIYGitGqGVItn~n~~~~~~~~GL~ydssgdL~gfKn~ttg~~YsV~PC~~g~VVGi~ 693 (1322) T 6NZK_A 614 TCSTDLQKANTDIILGVCVNYDLYGILGQGIFVEVNATYYNSWQNLLYDSNGNLYGFRDYITNRTFMIRSCYSGRVSAAF 693 (1322) T ss_dssp EEECSSCCCCCCCCBSSEEEEEETTEEEEEEEEEECCCCCCTTEEEEECTTSCEEEEECTTTCCEEEEECCCEECCEEEE T ss_pred cCCCcccccCceEEeCeeeeEEeCCccceEEEEecCCCceeccCcEEEcCCCCEEEEEcCCCCcEEEEEeCccCcEEEEE Confidence 9998 56799999999999999999999999964 5566778888888888889999999999999999999999998 Q sp|P0DTC2|SPIK 600 PGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVN--NSYECDIPIGAGICASYQTQ 677 (1273) Q Consensus 600 pgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvn--nsyecdipigagicasyqtq 677 (1273) ... ++..+.+|.++.|.+|....|..+++| .+-|+|-.||++++.+.. ...+|++|.|.|+|+.|.+ T Consensus 694 tS~--n~t~a~lF~n~~C~~v~~~~~~~~~~~--------~~~f~t~~Gcv~~a~~~t~~~v~~c~~~~g~~~C~~~~~- 762 (1322) T 6NZK_A 694 HAN--SSEPALLFRNIKCNYVFNNSLTRQLQP--------INYFDSYLGCVVNAYNSTAISVQTCDLTVGSGYCVDYSK- 762 (1322) T ss_dssp CTT--CSSCEEEEETCCHHHHHHTTTTTTCCC--------SCEEEETTEEEESSEEEEEEEESCCSEEEETTEEEEEC-- T ss_pred eCC--CCCccceeccceeceeeecccceeecc--------ccceeccccceecceecCCceeccccccccCceeeecCC- Confidence 765 445789999999999998766655555 233999999999999986 4889999999999999988 Q sp|P0DTC2|SPIK 678 TNSPRRARSVAS--QSIIAYTMSL-----GAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECS 750 (1273) Q Consensus 678 tnsprrarsvas--qsiiaytmsl-----gaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecs 750 (1273) |+++++... ..+..| +.+ ........+...|.||+||||+|++|-++++|.|.+|||.+|+||++.+|. T Consensus 763 ---~~gs~~~~~~~~~l~~~-~p~~~~~v~~~~~~~~~~~~IsIP~NFTlsvt~EyIQt~~~kVsIDCa~YVC~~~~~C~ 838 (1322) T 6NZK_A 763 ---NGGSGGAITTGYRFTNF-EPFTVNSVNDSLEPVGGLYEIQIPSEFTIGNMVEFIQTSSPKVTIDCAAFVCGDYAACK 838 (1322) T ss_dssp -----------CCSEEEEEE-CCCCCEEECCCSSCBTTBEEEEEEEEEEEEEEEEEEECCCCEEEECHHHHHSCSCHHHH T ss_pred ---CCCCCceeccCceeeec-cceeecccccCCCCCcceEEEEecCceeeEEEEEEeeecCCCeEEehhheecCCCHHHH Confidence 444433222 222233 222 111223455568999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 751 NLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKT----PPIKDF--GGFNFSQILPDPS----KPSKRSFIED 820 (1273) Q Consensus 751 nlllqygsfctqlnraltgiaveqdkntqevfaqvkqiykt----ppikdf--ggfnfsqilpdps----kpskrsfied 820 (1273) +||.|||+||..+|+||.+++..+|....+++..+++-++. +.+..| |+||||.+||.+. .+++||+||| T Consensus 839 ~LL~QYgs~C~~I~~aL~~v~~~~d~~~~~~~~~~~~~~~~s~~l~~~~~~~~g~fN~s~ll~~~~s~~~~~~~RSaIED 918 (1322) T 6NZK_A 839 SQLVEYGSFCDNINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSPVLGCLGSECSKASSRSAIED 918 (1322) T ss_dssp HHGGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCEEEGGGGTCCCCEETTEECTTTCCCCCC----CCSCCHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHhcCccccccccccccCCCCCccccccccCCCCCCCcCccccHHHH Confidence 99999999999999999999999999999999999998876 444445 6899999999875 3578999999 Q sp|P0DTC2|SPIK 821 LLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAM 900 (1273) Q Consensus 821 llfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfam 900 (1273) |||+||..+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++||++.||++|++|....|||+ |..||||+ T Consensus 919 LLFnKV~tsglG~~~~Yk~Ct~g~~i~DL~CAQyyNGImVLPpVvd~~~~amYTaSL~g~m~~gg~Ta----aaaIPFa~ 994 (1322) T 6NZK_A 919 LLFDKVKLSDVGFVEAYNNCTGGAEIRDLICVQSYKGIKVLPPLLSENQFSGYTLAATSASLFPPWTA----AAGVPFYL 994 (1322) T ss_dssp HHHHTCSSSHHHHHHHHHTTTTTCCTTCHHHHHHHTTEEEECCSSCHHHHHHHHHHHHHTTTSSSCGG----GTTCCHHH T ss_pred HHcceeeeCCcchHHHhHhccCCccHHHhhccceeCcEEEeCCCCCHHHHHHHHHHHHHHhhccCchh----cccCcchH Confidence 99999999999999999999999999999999999999999999999999999999999999999997 55689999 Q sp|P0DTC2|SPIK 901 QMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDI 980 (1273) Q Consensus 901 qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndi 980 (1273) ||.||+||+|+||+||.||||+|||.||.||+.||+.++.|++||.|+|||||++++||++|++||+.|||||||.++|| T Consensus 995 ~vq~RlN~v~lt~~VL~~NQk~iA~sFN~Ai~~iq~~f~tt~~AL~KiQ~VVN~q~~aL~~L~~qL~~nFgAISssI~DI 1074 (1322) T 6NZK_A 995 NVQYRINGLGVTMDVLSQNQKLIANAFNNALYAIQEGFDATNSALVKIQAVVNANAEALNNLLQQLSNRFGAISASLQEI 1074 (1322) T ss_dssp HHHHHHHTTTCCHHHHTTCHHHHHHHHHHHHHHHHHTTTSCCHHHHHHHHHHHHHHHHHHHHHGGGGCCTTSSCSCHHHH T ss_pred HHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 981 LSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGV 1060 (1273) Q Consensus 981 lsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgv 1060 (1273) ++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+||.||+|+ T Consensus 1075 y~RLD~LEAdaQVDRLItGRL~aLNafVtQ~L~~~~eVr~sr~LA~qKINECVKSQS~R~gFCGnG~Hi~Si~q~AP~Gi 1154 (1322) T 6NZK_A 1075 LSRLDALEAEAQIDRLINGRLTALNAYVSQQLSDSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGL 1154 (1322) T ss_dssp HHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSCCCSCCSSSTTSSEEEEEEEEETTEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCCCCeeEEEeeeccCCeE Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1061 VFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYD 1139 (1273) Q Consensus 1061 vflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvyd 1139 (1273) +|+|.+|+|.+.++.+++|.+|++| ++..|++|+|+.+...|++|.|++|+|..||.+|...-..|||...-+|+++.. T Consensus 1155 ~F~H~~~~Pt~~~~V~a~~GlC~~~~~~~~~~~g~f~~~n~~~~~T~r~~y~Pr~~t~~d~v~~~sC~v~y~n~~~~~l~ 1234 (1322) T 6NZK_A 1155 YFIHFSYVPTKYVTARVSPGLCIAGDRGIAPKSGYFVNVNNTWMYTGSGYYYPEPITENNVVVMSTCAVNYTKAPYVMLN 1234 (1322) T ss_dssp EEEEEEEEEEEEEEEEEESCEECTTSCEEEESSEEEEEETTEEEEEESSSCCEEECCGGGEEEESSCCTTSEECTTCCCC T ss_pred EEEEeEecccceEEEEEeeeEEecCCeeEEecceEEEeeCCEEEEeccCcccCCCCCccceEEeccceeEEEEcCcccCC Confidence 9999999999999999999999995 899999999999988999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1140 PLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNI-QKEIDRLNEVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1140 plqpeldsfkeeldkyfknhtspdvdlgdisginasvvni-qkeidrlnevaknlneslidlqelg 1204 (1273) |..|++..|+|||+|+|||+++...|+.. .-+|++++|+ ++||++|++++|+|+..-.+||.+- T Consensus 1235 ~~~p~~~df~~el~~~~~n~~~~~p~~~~-~~~N~t~Lnlt~~Ei~~L~~~~~~L~~~~~el~~~I 1299 (1322) T 6NZK_A 1235 TSIPNLPDFKEELDQWFKNQTSVAPDLSL-DYINVTFLDLLIKRMKQIEDKIEEIESKQKKIENEI 1299 (1322) T ss_dssp ------------------------------------------------------------------ T ss_pred CCCCCCCChHHHHHHHHhcCCCCCCCCCc-cccccceecccHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999985555543 2299999999 6999999999999999888887654 No 10 >6M15_A Spike glycoprotein; VIRAL PROTEIN; HET: BMA, NAG; 2.38A {Rhinolophus bat coronavirus HKU2} Probab=100.00 E-value=6.1e-154 Score=1294.04 Aligned_cols=832 Identities=28% Similarity=0.472 Sum_probs=633.8 Template_Neff=3.500 Q sp|P0DTC2|SPIK 273 RTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYA 352 (1273) Q Consensus 273 rtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvya 352 (1273) -++||.|+.||+|+|++||+-+|++|-+|..++|....|.|..+++++ |+-..+|.+++ ..|+|..++||.. +++. T Consensus 216 s~~Ll~fDvNGtItdaIdC~~Sp~~eLaCsy~SFnfsdGVYpfSny~v-pkfiVYR~ssv-~nctFsN~snA~p--Si~~ 291 (1118) T 6M15_A 216 SSVLVLTDQSGAVTRYSYCADGFVNGLQCKLRLFDIPPGVYSNSEVEY-PVALYTVVHNM-SVCPQRPESYCGS--NYCP 291 (1118) T ss_dssp EEEEEEECTTSCEEEEEETTSSHHHHHHHHHTCSSCCSEEEEEEECCC-CEEEESCCSCC-EECCCCCCCCCCS--SCCC T ss_pred eeeeeeecCCCcEEEEEeccCCcccccceEeccccCCCceeccCCcee-ceEEEEEecCc-ceeecCHHhcCCC--Cccc Confidence 468999999999999999999999999999999999999999999999 99888998888 8899999999988 9999 Q sp|P0DTC2|SPIK 353 WNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYN-YKLPDDFTG 431 (1273) Q Consensus 353 wnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadyn-yklpddftg 431 (1273) |.|+.++||..|+|.|. .+-+..|| |.+|. T Consensus 292 wqR~tfsNCNFNFSfLs---------------------------------------------Sdfm~SYN~y~~P~---- 322 (1118) T 6M15_A 292 FKRVVFSNCVVNYTSWT---------------------------------------------SGLLRDYQHLVLPN---- 322 (1118) T ss_dssp CCEEEECSEECCGGGGS---------------------------------------------CSCHHHHGGGBCTT---- T ss_pred cEEEEeeceeeeccEec---------------------------------------------CcchheeeeccCCC---- Confidence 99999999999999988 12222333 33343 Q sp|P0DTC2|SPIK 432 CVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEI------YQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGY 505 (1273) Q Consensus 432 cviawnsnnldskvggnynylyrlfrksnlkpferdistei------yqagstpcngvegfncyfplqsygfqptngvgy 505 (1273) | |- ++.+ .+-..|.++--.+.+-+- .....+-- |+-|...|-|+..-.|- . T Consensus 323 c----nF-nPet-Ngl~FNsl~g~Ckqsv~~--f~g~~tcCy~~VIS~~~gp~~ckG~~~geCg---------------~ 379 (1118) T 6M15_A 323 G----KF-NPFT-ECNGLNRIVDDCVTGFVL--RVGRGTAVNRTVITPYLKPNECFGWSWNDYQ---------------D 379 (1118) T ss_dssp S----CB-CSCS-EEESBCSSCCSEEECEEE--EEEEEECBTTBCCCCCCCTTEEEEEEEEETT---------------T T ss_pred C----CC-CCcc-CCcCCccccCCCccceEE--EecCceeeEEEEECCCCCCCccceeeecccc---------------c Confidence 1 10 0111 111111100000000000 00000000 01133334444433221 0 Q sp|P0DTC2|SPIK 506 QPYRVVVLSFEL-L-HAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLE 583 (1273) Q Consensus 506 qpyrvvvlsfel-l-hapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtle 583 (1273) -|-..+.| - -.++|+|.. ..++++.++||++|..|.+|+||++++|..+..+|.+..+-.| ..++++ +++ T Consensus 380 ----~Vyv~~~~~g~S~~aTvCPv-d~tnI~Ld~CVdYNIYG~tGqGVItnsn~~~~~~q~GLy~ts~-L~~vk~--tg~ 451 (1118) T 6M15_A 380 ----SIYDWWIADFVSTGAFVCEK-NPDAPRTGVCITYTIEKVTFQGVLYESNFTFAQYYNVLYFGSQ-LKYVRI--LGK 451 (1118) T ss_dssp ----TEEEEEEEECCCCSCEEESS-CCCCCCTTSEEEEEETTEEEEEEEEECCCCCCTTCSEEEETTE-EEEEEE--TTE T ss_pred ----eEEeEeecCCccCCcccCCC-CCCCCccCeeEeEEeCCceeeEEEEEcCccceehhceEEEeee-eEEEEe--CCc Confidence 22333333 1 356899988 6689999999999999999999999999988888888777444 467777 999 Q sp|P0DTC2|SPIK 584 ILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN--SYE 661 (1273) Q Consensus 584 ilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnn--sye 661 (1273) +..|+||..+.++++..| ++.++.|++.+||.++.+..+.. +.||-.++. -|||-.||++++...++ ..+ T Consensus 452 ~Y~V~PC~~v~qQvVv~~---~~~vglLt~S~ncn~~~~~~~~~---~~r~~~~~~--~fdt~~Gcv~~~~n~~~~~~~~ 523 (1118) T 6M15_A 452 VYEVAPCFEASYDVLFRS---SSSFGLLYRSFDCNQLRISASRF---AERLLPSHN--GTATALGCLFNATYAPNDTMVN 523 (1118) T ss_dssp EEEEECCTTSEEEEEEEE---TTEEEEEETTCCCCHHHHTSSTT---TTTCCGGGC--SEEETTEEEESSEEEEEEEESS T ss_pred EEEEecCcccceeEEEeC---CCeEEEEEcccccceeeeecccc---ccccCCCCC--CcccceeeEEEeecCCCCCCcc Confidence 999999999999999988 47899999999998887655544 334443333 39999999999987744 699 Q sp|P0DTC2|SPIK 662 CDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMY 741 (1273) Q Consensus 662 cdipigagicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmy 741 (1273) |+.|+|.|||+.+ .-.-.+||.+-+ .+. ... .+.....+.|.||+||||+|++|-++++|.|.+|||.+| T Consensus 524 C~~p~g~giC~dg-~~~~~~r~~~l~------~~~-~~~--v~p~~~~~~IsIPtNFTlsvt~EYIQt~~~kVsVDCa~Y 593 (1118) T 6M15_A 524 CTNPLGDGFCADL-LSNVVVRRMTFE------KHD-TTY--VAPVTNERFTELPLDHQLVLTEQFLQTTMPKFSISCETY 593 (1118) T ss_dssp CSSEEETTEEEEC-SSSCEEEEECCC------CBC-CSC--CCCCCSSEEEEEEEEEEEEEEEEEEECCCCEEEECHHHH T ss_pred CCCCceeeEecCC-cceeceeeeeee------ccc-ccc--ccCcccceeEEccCceEeEEEEEEEeccCCCeEEecchh Confidence 9999999999999 333334432222 221 111 122334477899999999999999999999999999999 Q sp|P0DTC2|SPIK 742 ICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQI-LPDPS----KPSKRS 816 (1273) Q Consensus 742 icgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqi-lpdps----kpskrs 816 (1273) +||++.+|.+||.|||+||..+|+||.+.+..+|.+..+++..+|..... +....|+||||++ +|..+ ++++|| T Consensus 594 VCngn~~C~~LL~QYgs~C~~I~~aL~~~a~led~~~~~~~s~~~~~~~~-~~~~~~~FN~S~~~lp~~~~~~~~~~~RS 672 (1118) T 6M15_A 594 ICDVSKACKNLLFRYGGFCQKIEADIRGAGVLLDSDVSGLYSTIAAKTSS-ITPTTDRFNVSQFFLPKVQSNSERFESRS 672 (1118) T ss_dssp HSSSCHHHHTTGGGSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHBBCCCS-SCCBCSSCCCTTTTSCCCCCSSSCCCCCC T ss_pred ccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhhhHHHHHHHHHHhhhccC-cCCCCCCccccccccCCCCCCCccccccc Confidence 99999999999999999999999999999999999999999888766433 3366888999998 67654 346899 Q sp|P0DTC2|SPIK 817 FIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGA--GAAL 894 (1273) Q Consensus 817 fiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfga--gaal 894 (1273) +||||||+||..+|.|+.+.|.+|.+ -.+|||+|||.+||+.||||++++||++.|| +.++.||+||+ ++|. T Consensus 673 ~IEDLLF~KV~t~glG~~~~Yk~Ct~-~~i~DL~CaQyyNGimVLP~v~d~~~~amYT-----asl~ggm~~Ggit~sAa 746 (1118) T 6M15_A 673 VIEDLLFSKIETTGPGFYGDYYNCKK-NAIQDLTCAQYHNGILVIPPVMDAETLGMYG-----GIAAASLTLGIFGGQAG 746 (1118) T ss_dssp HHHHHHHHSSCCCCSSHHHHHHHHHH-HCCTTCCCCCEETTEEEECCSSCGGGCCTTS-----STTCBCSSTTTTCSSCC T ss_pred HHHHHhccceEecCCCchHhHHHhhc-chhhHHhcccccCcEEEcCCCCCHHHHHHHH-----HHHHHHHHhhhhcchhc Confidence 99999999999999999999999999 6799999999999999999999999999999 44566899988 6789 Q sp|P0DTC2|SPIK 895 QIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAIS 974 (1273) Q Consensus 895 qipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgais 974 (1273) .|||||||.||+||+|+||+||.||||+|||.||.|++.||+.++.+++||.|+|||||++++||++|++||+.|||||| T Consensus 747 aiPFa~~vq~RlN~valt~~VL~~NQk~iA~sFN~A~~~iq~~f~tt~~AL~KIQ~VVN~q~~aL~~L~~QL~nnFgAIS 826 (1118) T 6M15_A 747 ITTWSLAMAGRLNALGVVQNALVDDVNKLANGFNQLTASVGKLALTTSSALQAIQAVVNQNAAQVESLVSGITENFGAIS 826 (1118) T ss_dssp CCBHHHHHHHHHHHTTSCSSCCHHHHHHHHHHHHHHHHTGGGCCTTTCHHHHHHHHHHHHHHHHHHHHHHTTTSCTTSSC T ss_pred hhhHHHHHHHHHhhhhhchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 975 SVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQ 1054 (1273) Q Consensus 975 svlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpq 1054 (1273) |.++||++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+|| T Consensus 827 SSI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtq~l~~~~ev~~sr~LA~qKINECVKSQS~R~GFCGnGtHi~Si~q 906 (1118) T 6M15_A 827 TNFKVISQRLDKLEADVQMDRLINGRMNVLQLFVTNYKLKIAELRNTHRYVQSLINECVYAQSLRNGFCGQGLHVLSLMQ 906 (1118) T ss_dssp SCHHHHHHHBCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTTSSSEEEEEEEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccCcccCCCCCCeEeEeecc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1055 SAPHGVVFLHVTYVPAQEKNFTTAPAICHD----GKAHFPREGVFVSNG-THWFVTQRNFYEPQIITTDNTFVSGNCDVV 1129 (1273) Q Consensus 1055 saphgvvflhvtyvpaqeknfttapaichd----gkahfpregvfvsng-thwfvtqrnfyepqiittdntfvsgncdvv 1129 (1273) .||+|++|+|.+|+|.+-++.+++|.+|++ +++..||+|+|+.+. +.|++|.|++|+|..||.+|.... .||+. T Consensus 907 ~APnGi~F~H~~y~Pt~~~~V~a~~GlC~~~~~~~~~~~~~~g~f~~~n~~~w~iT~r~my~Pr~it~~d~v~~-sc~v~ 985 (1118) T 6M15_A 907 NAPSGIMFFHYSLIPNNTITVKTTPGLCESDELGSKCIVAKDGVLVSANLSYWQWSPRNLYKPENLTFANVIAV-SRGAN 985 (1118) T ss_dssp EETTEEEEEEEEEEEEEEEEEEEESCEESSSSTTCCEEEESSSEEEESSCSSCEEECTTSCCCEECCTTTEEEE-CCCTT T ss_pred cCCCeEEEEEEEeccCceeEEEEeeeeEccCCCCCcEEEecccEEEEcCCCEEEECccccccCCCCCccCeEEE-ecCce Confidence 999999999999999999999999999999 457999999999864 999999999999999999998777 78999 Q sp|P0DTC2|SPIK 1130 IGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQY 1209 (1273) Q Consensus 1130 igivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqy 1209 (1273) ...+|.++..|..|++-.|+|||+|+|||+++.-.||.+.+ +|++++|++.||++|+|+.|+||+++|||++|++||+| T Consensus 986 y~~vn~t~~~p~ipd~~Df~eel~e~~kn~s~~~pdl~~~~-~N~T~LNLs~EI~~LqevIk~LN~s~IdLe~L~~~e~Y 1064 (1118) T 6M15_A 986 YTTLNRTFDIPELNSTFPIDEEFREYFQNMSSELQALKNLT-ADMSKLNISAEIQLINEIAHNVSNMRVEVEKFQRYVNY 1064 (1118) T ss_dssp CEECSSCCCC---------------------------------------------------------------------- T ss_pred EEEeccccCCCCCcCCCChHHHHHHHHhhcCccccccccce-ecCceechHHHHHHHHHHHHHHHhccccHHHhCeeeEE Confidence 99999999999999999999999999999988777787766 99999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1210 IKWPWY 1215 (1273) Q Consensus 1210 ikwpwy 1215 (1273) |||.-. T Consensus 1065 iKW~~~ 1070 (1118) T 6M15_A 1065 VKLEVL 1070 (1118) T ss_dssp ------ T ss_pred eeceee Confidence 999854 No 11 >6M15_B Spike glycoprotein; VIRAL PROTEIN; HET: NAG, BMA; 2.38A {Rhinolophus bat coronavirus HKU2} Probab=100.00 E-value=6.1e-154 Score=1294.04 Aligned_cols=832 Identities=28% Similarity=0.472 Sum_probs=633.8 Template_Neff=3.500 Q sp|P0DTC2|SPIK 273 RTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYA 352 (1273) Q Consensus 273 rtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvya 352 (1273) -++||.|+.||+|+|++||+-+|++|-+|..++|....|.|..+++++ |+-..+|.+++ ..|+|..++||.. +++. T Consensus 216 s~~Ll~fDvNGtItdaIdC~~Sp~~eLaCsy~SFnfsdGVYpfSny~v-pkfiVYR~ssv-~nctFsN~snA~p--Si~~ 291 (1118) T 6M15_B 216 SSVLVLTDQSGAVTRYSYCADGFVNGLQCKLRLFDIPPGVYSNSEVEY-PVALYTVVHNM-SVCPQRPESYCGS--NYCP 291 (1118) T ss_dssp EEEEEEECTTSCEEEEEETTSSHHHHHHHHHTCSSCCSEEEEEEECCC-CEEEESCCSCC-EECCCCCCCCCCS--SCCC T ss_pred eeeeeeecCCCcEEEEEeccCCcccccceEeccccCCCceeccCCcee-ceEEEEEecCc-ceeecCHHhcCCC--Cccc Confidence 468999999999999999999999999999999999999999999999 99888998888 8899999999988 9999 Q sp|P0DTC2|SPIK 353 WNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYN-YKLPDDFTG 431 (1273) Q Consensus 353 wnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadyn-yklpddftg 431 (1273) |.|+.++||..|+|.|. .+-+..|| |.+|. T Consensus 292 wqR~tfsNCNFNFSfLs---------------------------------------------Sdfm~SYN~y~~P~---- 322 (1118) T 6M15_B 292 FKRVVFSNCVVNYTSWT---------------------------------------------SGLLRDYQHLVLPN---- 322 (1118) T ss_dssp CCEEEECSEECCGGGGS---------------------------------------------CSCHHHHGGGBCTT---- T ss_pred cEEEEeeceeeeccEec---------------------------------------------CcchheeeeccCCC---- Confidence 99999999999999988 12222333 33343 Q sp|P0DTC2|SPIK 432 CVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEI------YQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGY 505 (1273) Q Consensus 432 cviawnsnnldskvggnynylyrlfrksnlkpferdistei------yqagstpcngvegfncyfplqsygfqptngvgy 505 (1273) | |- ++.+ .+-..|.++--.+.+-+- .....+-- |+-|...|-|+..-.|- . T Consensus 323 c----nF-nPet-Ngl~FNsl~g~Ckqsv~~--f~g~~tcCy~~VIS~~~gp~~ckG~~~geCg---------------~ 379 (1118) T 6M15_B 323 G----KF-NPFT-ECNGLNRIVDDCVTGFVL--RVGRGTAVNRTVITPYLKPNECFGWSWNDYQ---------------D 379 (1118) T ss_dssp S----CB-CSCS-EEESBCSSCCSEEECEEE--EEEEEECBTTBCCCCCCCTTEEEEEEEEETT---------------T T ss_pred C----CC-CCcc-CCcCCccccCCCccceEE--EecCceeeEEEEECCCCCCCccceeeecccc---------------c Confidence 1 10 0111 111111100000000000 00000000 01133334444433221 0 Q sp|P0DTC2|SPIK 506 QPYRVVVLSFEL-L-HAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLE 583 (1273) Q Consensus 506 qpyrvvvlsfel-l-hapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtle 583 (1273) -|-..+.| - -.++|+|.. ..++++.++||++|..|.+|+||++++|..+..+|.+..+-.| ..++++ +++ T Consensus 380 ----~Vyv~~~~~g~S~~aTvCPv-d~tnI~Ld~CVdYNIYG~tGqGVItnsn~~~~~~q~GLy~ts~-L~~vk~--tg~ 451 (1118) T 6M15_B 380 ----SIYDWWIADFVSTGAFVCEK-NPDAPRTGVCITYTIEKVTFQGVLYESNFTFAQYYNVLYFGSQ-LKYVRI--LGK 451 (1118) T ss_dssp ----TEEEEEEEECCCCSCEEESS-CCCCCCTTSEEEEEETTEEEEEEEEECCCCCCTTCSEEEETTE-EEEEEE--TTE T ss_pred ----eEEeEeecCCccCCcccCCC-CCCCCccCeeEeEEeCCceeeEEEEEcCccceehhceEEEeee-eEEEEe--CCc Confidence 22333333 1 356899988 6689999999999999999999999999988888888777444 467777 999 Q sp|P0DTC2|SPIK 584 ILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN--SYE 661 (1273) Q Consensus 584 ilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnn--sye 661 (1273) +..|+||..+.++++..| ++.++.|++.+||.++.+..+.. +.||-.++. -|||-.||++++...++ ..+ T Consensus 452 ~Y~V~PC~~v~qQvVv~~---~~~vglLt~S~ncn~~~~~~~~~---~~r~~~~~~--~fdt~~Gcv~~~~n~~~~~~~~ 523 (1118) T 6M15_B 452 VYEVAPCFEASYDVLFRS---SSSFGLLYRSFDCNQLRISASRF---AERLLPSHN--GTATALGCLFNATYAPNDTMVN 523 (1118) T ss_dssp EEEEECCTTSEEEEEEEE---TTEEEEEETTCCCCHHHHTSSTT---TTTCCGGGC--SEEETTEEEESSEEEEEEEESS T ss_pred EEEEecCcccceeEEEeC---CCeEEEEEcccccceeeeecccc---ccccCCCCC--CcccceeeEEEeecCCCCCCcc Confidence 999999999999999988 47899999999998887655544 334443333 39999999999987744 699 Q sp|P0DTC2|SPIK 662 CDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMY 741 (1273) Q Consensus 662 cdipigagicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmy 741 (1273) |+.|+|.|||+.+ .-.-.+||.+-+ .+. ... .+.....+.|.||+||||+|++|-++++|.|.+|||.+| T Consensus 524 C~~p~g~giC~dg-~~~~~~r~~~l~------~~~-~~~--v~p~~~~~~IsIPtNFTlsvt~EYIQt~~~kVsVDCa~Y 593 (1118) T 6M15_B 524 CTNPLGDGFCADL-LSNVVVRRMTFE------KHD-TTY--VAPVTNERFTELPLDHQLVLTEQFLQTTMPKFSISCETY 593 (1118) T ss_dssp CSSEEETTEEEEC-SSSCEEEEECCC------CBC-CSC--CCCCCSSEEEEEEEEEEEEEEEEEEECCCCEEEECHHHH T ss_pred CCCCceeeEecCC-cceeceeeeeee------ccc-ccc--ccCcccceeEEccCceEeEEEEEEEeccCCCeEEecchh Confidence 9999999999999 333334432222 221 111 122334477899999999999999999999999999999 Q sp|P0DTC2|SPIK 742 ICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQI-LPDPS----KPSKRS 816 (1273) Q Consensus 742 icgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqi-lpdps----kpskrs 816 (1273) +||++.+|.+||.|||+||..+|+||.+.+..+|.+..+++..+|..... +....|+||||++ +|..+ ++++|| T Consensus 594 VCngn~~C~~LL~QYgs~C~~I~~aL~~~a~led~~~~~~~s~~~~~~~~-~~~~~~~FN~S~~~lp~~~~~~~~~~~RS 672 (1118) T 6M15_B 594 ICDVSKACKNLLFRYGGFCQKIEADIRGAGVLLDSDVSGLYSTIAAKTSS-ITPTTDRFNVSQFFLPKVQSNSERFESRS 672 (1118) T ss_dssp HSSSCHHHHTTGGGSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHBBCCCS-SCCBCSSCCCTTTTSCCCCCSSSCCCCCC T ss_pred ccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhhhHHHHHHHHHHhhhccC-cCCCCCCccccccccCCCCCCCccccccc Confidence 99999999999999999999999999999999999999999888766433 3366888999998 67654 346899 Q sp|P0DTC2|SPIK 817 FIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGA--GAAL 894 (1273) Q Consensus 817 fiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfga--gaal 894 (1273) +||||||+||..+|.|+.+.|.+|.+ -.+|||+|||.+||+.||||++++||++.|| +.++.||+||+ ++|. T Consensus 673 ~IEDLLF~KV~t~glG~~~~Yk~Ct~-~~i~DL~CaQyyNGimVLP~v~d~~~~amYT-----asl~ggm~~Ggit~sAa 746 (1118) T 6M15_B 673 VIEDLLFSKIETTGPGFYGDYYNCKK-NAIQDLTCAQYHNGILVIPPVMDAETLGMYG-----GIAAASLTLGIFGGQAG 746 (1118) T ss_dssp HHHHHHHHSSCCCCSSHHHHHHHHHH-HCCTTCCCCCEETTEEEECCSSCGGGCCTTS-----STTCBCSSTTTTCSSCC T ss_pred HHHHHhccceEecCCCchHhHHHhhc-chhhHHhcccccCcEEEcCCCCCHHHHHHHH-----HHHHHHHHhhhhcchhc Confidence 99999999999999999999999999 6799999999999999999999999999999 44566899988 6789 Q sp|P0DTC2|SPIK 895 QIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAIS 974 (1273) Q Consensus 895 qipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgais 974 (1273) .|||||||.||+||+|+||+||.||||+|||.||.|++.||+.++.+++||.|+|||||++++||++|++||+.|||||| T Consensus 747 aiPFa~~vq~RlN~valt~~VL~~NQk~iA~sFN~A~~~iq~~f~tt~~AL~KIQ~VVN~q~~aL~~L~~QL~nnFgAIS 826 (1118) T 6M15_B 747 ITTWSLAMAGRLNALGVVQNALVDDVNKLANGFNQLTASVGKLALTTSSALQAIQAVVNQNAAQVESLVSGITENFGAIS 826 (1118) T ss_dssp CCBHHHHHHHHHHHTTSCSSCCHHHHHHHHHHHHHHHHTGGGCCTTTCHHHHHHHHHHHHHHHHHHHHHHTTTSCTTSSC T ss_pred hhhHHHHHHHHHhhhhhchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 975 SVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQ 1054 (1273) Q Consensus 975 svlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpq 1054 (1273) |.++||++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+|| T Consensus 827 SSI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtq~l~~~~ev~~sr~LA~qKINECVKSQS~R~GFCGnGtHi~Si~q 906 (1118) T 6M15_B 827 TNFKVISQRLDKLEADVQMDRLINGRMNVLQLFVTNYKLKIAELRNTHRYVQSLINECVYAQSLRNGFCGQGLHVLSLMQ 906 (1118) T ss_dssp SCHHHHHHHBCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTTSSSEEEEEEEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccCcccCCCCCCeEeEeecc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1055 SAPHGVVFLHVTYVPAQEKNFTTAPAICHD----GKAHFPREGVFVSNG-THWFVTQRNFYEPQIITTDNTFVSGNCDVV 1129 (1273) Q Consensus 1055 saphgvvflhvtyvpaqeknfttapaichd----gkahfpregvfvsng-thwfvtqrnfyepqiittdntfvsgncdvv 1129 (1273) .||+|++|+|.+|+|.+-++.+++|.+|++ +++..||+|+|+.+. +.|++|.|++|+|..||.+|.... .||+. T Consensus 907 ~APnGi~F~H~~y~Pt~~~~V~a~~GlC~~~~~~~~~~~~~~g~f~~~n~~~w~iT~r~my~Pr~it~~d~v~~-sc~v~ 985 (1118) T 6M15_B 907 NAPSGIMFFHYSLIPNNTITVKTTPGLCESDELGSKCIVAKDGVLVSANLSYWQWSPRNLYKPENLTFANVIAV-SRGAN 985 (1118) T ss_dssp EETTEEEEEEEEEEEEEEEEEEEESCEESSSSTTCCEEEESSSEEEESSCSSCEEECTTSCCCEECCTTTEEEE-CCCTT T ss_pred cCCCeEEEEEEEeccCceeEEEEeeeeEccCCCCCcEEEecccEEEEcCCCEEEECccccccCCCCCccCeEEE-ecCce Confidence 999999999999999999999999999999 457999999999864 999999999999999999998777 78999 Q sp|P0DTC2|SPIK 1130 IGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQY 1209 (1273) Q Consensus 1130 igivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqy 1209 (1273) ...+|.++..|..|++-.|+|||+|+|||+++.-.||.+.+ +|++++|++.||++|+|+.|+||+++|||++|++||+| T Consensus 986 y~~vn~t~~~p~ipd~~Df~eel~e~~kn~s~~~pdl~~~~-~N~T~LNLs~EI~~LqevIk~LN~s~IdLe~L~~~e~Y 1064 (1118) T 6M15_B 986 YTTLNRTFDIPELNSTFPIDEEFREYFQNMSSELQALKNLT-ADMSKLNISAEIQLINEIAHNVSNMRVEVEKFQRYVNY 1064 (1118) T ss_dssp CEECSSCCCC---------------------------------------------------------------------- T ss_pred EEEeccccCCCCCcCCCChHHHHHHHHhhcCccccccccce-ecCceechHHHHHHHHHHHHHHHhccccHHHhCeeeEE Confidence 99999999999999999999999999999988777787766 99999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1210 IKWPWY 1215 (1273) Q Consensus 1210 ikwpwy 1215 (1273) |||.-. T Consensus 1065 iKW~~~ 1070 (1118) T 6M15_B 1065 VKLEVL 1070 (1118) T ss_dssp ------ T ss_pred eeceee Confidence 999854 No 12 >6JX7_A Feline Infectious Peritonitis Virus Spike; CoV spike protein, VIRAL PROTEIN; HET: NAG, MAN, FUC, BMA; 3.31A {Feline infectious peritonitis virus} Probab=100.00 E-value=2e-132 Score=1149.25 Aligned_cols=664 Identities=33% Similarity=0.532 Sum_probs=532.7 Template_Neff=4.600 Q sp|P0DTC2|SPIK 525 CGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTN- 603 (1273) Q Consensus 525 cgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitpgtn- 603 (1273) -|-...++++.++||++|.-|.+|+|++++++..+... .+-.|...-.++.++..++++..|+||....++|+..|+. T Consensus 674 ~g~~d~~~i~l~~Cv~YnIYG~tG~GvI~~~~~~~~~G-l~~~s~sG~l~~Fk~~~~~~~Y~V~PC~~~~Q~vV~~~~iV 752 (1468) T 6JX7_A 674 LGFQDISNIVKDECTDYNIYGFQGTGIIRSTTSRLVAG-LYYTSASGDLLGFKISTTGEIFTVVPCDLTAQAAVINDEIV 752 (1468) T ss_dssp CSCSSCCCCCBSSEEEEEETTEEEEEEEEECCCCCCSC-SEEECTTSCEEEEECSSSSCEEEEECSSCCEEEEESSSSEE T ss_pred ceeeccceeEeccceeEEeCCccceEEEEecCeeeeCc-EEEEcCCCCEEEEEeCCCCCEEEEEeCCcCceEEEECCeEE Confidence 34456789999999999999999999999999888655 6667777778999999999999999999999999999875 Q sp|P0DTC2|SPIK 604 ---TSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNS 680 (1273) Q Consensus 604 ---tsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsyecdipigagicasyqtqtns 680 (1273) ||...+.+++.+||+++..+.+ .++. ..+.++|-.||.+++.+...+.+|+.++|.|.|+-+.+-. T Consensus 753 G~ltS~n~~~~~~~~nct~v~~s~~---s~~~------~~~~~~TP~fcy~~~~~~~~~~~c~~~l~yg~~~i~~dG~-- 821 (1468) T 6JX7_A 753 GAITATNQTDLFEFVNHTWSRSARG---SSPS------TVNTYTMPQFYYITKWNNGTSSNCTSVITYSSFAICNTGE-- 821 (1468) T ss_dssp EEEESSSCCCSSSCSCC--------------C------CCCEEECSSCEEECSCCSSSCCCCCCCBCCTTEEECTTSC-- T ss_pred EEEEccCcccccccceeeeeeeecc---CCCC------cccceecceeEEEeeccCCccccccceeeeceEEEcCCCc-- Confidence 7788889999999999884433 1111 3455999999999999888899999999999888776621 Q sp|P0DTC2|SPIK 681 PRRARSVASQSIIAYTMSLGAE-NS--VAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYG 757 (1273) Q Consensus 681 prrarsvasqsiiaytmslgae-ns--vaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqyg 757 (1273) .+-+ -...+++... .. ..-....|.||+||||+|++|-+.++|.|.+|||.+|+||++.+|.+||.||| T Consensus 822 ---i~~v-----~~~~~~~~~~~~~~~~~~~t~~v~IP~nFt~~v~~EyiQ~~~~kv~idC~~YVC~~~~~C~~ll~qYg 893 (1468) T 6JX7_A 822 ---IKYV-----NVTHVEIVDDSVGVIKPVSTGNITIPKNFTVAVQAEYVQIQVKPVAVDCAKYVCNGNRHCLNLLTQYT 893 (1468) T ss_dssp ---EEEC-----CCEECSSSSCSSSSCCCCCSSEEECCCCEEEEEEEEEECCCCCCEEECHHHHHSSSCHHHHTTGGGGH T ss_pred ---EEEE-----eceeeeeeeCccccccceeEEEEEecCCeeEEEEEEEEeccCCceEEechhhhcCCCHHHHHHHHHHh Confidence 1111 0000111000 00 11123478999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 758 SFCTQLNRALTGIAVEQDKNTQEVFAQVKQ-IYKTPPIKDFG-------------GFNFSQILPDPSKPSKRSFIEDLLF 823 (1273) Q Consensus 758 sfctqlnraltgiaveqdkntqevfaqvkq-iyktppikdfg-------------gfnfsqilpdpskpskrsfiedllf 823 (1273) +||..+++||.+.+ .+|......+..+.. -++++-+.+|. ++|++.+||.+. ++||+|||||| T Consensus 894 s~C~~I~~al~~~~-~ld~~~~~~~~~~~~~~~~~~~~~~fn~~~~~~~~~g~~~~~~~s~~l~~~~--~~RS~IEDLLF 970 (1468) T 6JX7_A 894 SACQTIENSLNLGA-RLESLMLNDMITVSDRSLEFATVDKFNTTALGGEKLGGLYFDGLSSLLPPRV--GMRSAVEDLLF 970 (1468) T ss_dssp HHHHHHHHHHHHHH-HHHHHHHTTTCEECHHHHTTCSTTTTTSCCSSSCCSSCTTHHHHHHHSCSSS--SSCCHHHHHHT T ss_pred HHHHHHHHHHHHHH-HHHHHhHhhcceeccccccccCcccccCcccCcccccccccCCcccCCCCCC--CCCcHHHHHhc Confidence 99999999999988 666443334444332 44555565553 267787787654 79999999999 Q sp|P0DTC2|SPIK 824 NKVTLADAGFIK-QYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQM 902 (1273) Q Consensus 824 nkvtladagfik-qygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqm 902 (1273) +||..+|.|+++ .|.+|.+...+|||+|||.+||+.||||++++||++.||++|++|....|||. |..||||+|| T Consensus 971 ~KV~t~glg~vd~~Y~~C~~g~~i~DL~CaQ~yNGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~t~----aaaiPFa~~v 1046 (1468) T 6JX7_A 971 NKVVTSGLGTVDDDYKKCSAGTDVADLVCAQYYNGIMVLPGVVDYNKMAMYTASLIGGMALGSITS----AVAVPFSMQV 1046 (1468) T ss_dssp TTTTTTTCCCCCCCSTTTTTCSSSCCHHHHHHHTTEEECCCSSCHHHHHHHHHHHHHHHHCCCTTC----CCCCCHHHHH T ss_pred ccEEecCCCcCCHHHHHccCCccHHHHhCccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhcchhh----eecccHHHHH Confidence 999999999999 69999999999999999999999999999999999999999999999999996 6679999999 Q sp|P0DTC2|SPIK 903 AYRFNGIGVTQNVLYENQKLIANQFNSAIGKI--------------QDSLSSTASALGKLQDVVNQNAQALNTLVKQLSS 968 (1273) Q Consensus 903 ayrfngigvtqnvlyenqklianqfnsaigki--------------qdslsstasalgklqdvvnqnaqalntlvkqlss 968 (1273) .+|+|++|+||+||.||||+|||.||.|||.| |+.++++++||.|+|||||++++||++|++||+. T Consensus 1047 q~RlN~v~lt~~vL~~NQk~iA~sFN~A~~~it~af~~v~~ai~~t~~gf~t~~~Al~kiQ~VVN~q~~aL~~l~~qL~~ 1126 (1468) T 6JX7_A 1047 QARLNYVALQTDVLQENQKILANAFNNAIGNITLALGKVSNAITTVSDGFNSMASALTKIQSVVNQQGEALSHLISQLQK 1126 (1468) T ss_dssp HHHHHTTSCCCSCCHHHHHHHHHHHHHHHHHHHHHHHSCCSCSCCCCSHHHHHHHHHHHHHHHTTTHHHHHHHHHGGGSC T ss_pred HHHhhhhhhchHHHHHHHHHHHHHHHHHHHHHHHHhhhhhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999 6668999999999999999999999999999999 Q sp|P0DTC2|SPIK 969 NFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYH 1048 (1273) Q Consensus 969 nfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyh 1048 (1273) |||||||.++||.+|||++||++|+||||+|||.+|++||+|+|+|++|+|+|+.||..|+.|||..||+|.+|||.|.| T Consensus 1127 nFgAISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~LA~qKinECVksQS~R~gFCGnG~H 1206 (1468) T 6JX7_A 1127 NFQAISSSIAEIYNRLEKVEADAQVDRLITGRLAALNAYVAQTLTQYAEVKASRQLAMEKVNECVKSQSDRYGFCGNGTH 1206 (1468) T ss_dssp CTTSSCSCHHHHTTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCTTCCCCTTSSSSSSE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccCCCCCCee Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1049 LMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPRE--GVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGN 1125 (1273) Q Consensus 1049 lmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpre--gvfvsngthwfvtqrnfyepqiittdntfvsgn 1125 (1273) ++|+||.||.|++|+|.+|+|.+-++.+++|.+|+++ ++..||+ ++|+.+...|++|.|++|||..||.+|...-.. T Consensus 1207 v~S~~q~APnGi~F~H~~~~Pt~~~~v~a~~GlC~~~~~~~~~~~~~~~~~~~n~~~~~T~r~~y~Pr~~t~~d~v~~~s 1286 (1468) T 6JX7_A 1207 LFSLVNSAPDGLLFFHTVLLPTEWEEVTAWSGICVNDTYAYLLKDFDHSIFSYNGTYMVTPRNMFQPRKPQMSDFVQITS 1286 (1468) T ss_dssp EEEEEEEETTEEEEEEEEEEECCCCEEECBSCEEETTTEEEEESSSSEEEEESSSCEEEEESSSCCCBCCCGGGEEEESC T ss_pred eEeeeecCCCeEEEEEEEeccCceEEEEEEEEEeecCCeeEEeecCceEEEeeCCEEEEeccccccCCCCCccceEEeec Confidence 9999999999999999999999999999999999995 7889998 999998889999999999999999999999999 Q sp|P0DTC2|SPIK 1126 CDVVIGIVNNTVYDPLQPEL----DSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRL--------------N 1187 (1273) Q Consensus 1126 cdvvigivnntvydplqpel----dsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrl--------------n 1187 (1273) |||...-++.++..+..|++ +.|+|||++++|||++|+.++.. ..+|+++.||+.||++| + T Consensus 1287 C~v~y~n~~~~~~~~~~p~~~d~n~~~~~~~~~~~~n~t~~~~~~~~-~~~n~t~Lnl~~Ei~~l~~~~~~l~~~~~~~~ 1365 (1468) T 6JX7_A 1287 CEVTFLNTTHTTFQEIVIDYIDINKTIADMLEQYHSNYTTPELDLQL-EIFNQTKLNLTAEIDQLEQRADNLTNIAHELQ 1365 (1468) T ss_dssp CCTTSEEECHHHHHHHSTTCCCHHHHHHHHHHHHTC-------------------------------------------- T ss_pred CeeEEEEcccccccccccCccccCHhHHHHHHHhcCCCCCcccccCc-cccccceecHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999 99999999999999999997765 88999999999999997 9 Q sp|P0DTC2|SPIK 1188 EVAKNLNESLIDLQELGKYEQYIKWPWYI 1216 (1273) Q Consensus 1188 evaknlneslidlqelgkyeqyikwpwyi 1216 (1273) |+.|+||+++|||++|++||+||||||.- T Consensus 1366 ~~i~~lN~s~idLe~L~~~e~YiKWPW~~ 1394 (1468) T 6JX7_A 1366 QYIDNLNKTIVDLEWLNRIETYVKWPGSG 1394 (1468) T ss_dssp ----------------------------- T ss_pred HHHHHHHhcCccHHHHceeEeEecCcccc Confidence 99999999999999999999999999963 No 13 >5SZS_A Spike glycoprotein; coronavirus, viral fusion protein, vaccine; HET: MAN, NAG, BMA; 3.4A {Human coronavirus NL63} Probab=100.00 E-value=7.1e-131 Score=1128.95 Aligned_cols=662 Identities=31% Similarity=0.515 Sum_probs=529.3 Template_Neff=4.500 Q sp|P0DTC2|SPIK 505 YQPYRVVVLSFE----LLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQ 580 (1273) Q Consensus 505 yqpyrvvvlsfe----llhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpq 580 (1273) ++.+..|-+++. ...+|..+.|-...+++..++||++|.-|.+|+|++++++..+...+.+ .+.+.-..++++.. T Consensus 575 ~~~~~~VYVt~s~GsrItgv~~p~~g~~d~~~i~l~~CvdYnIYG~tG~GvI~n~n~~~~~Gl~~-tS~sg~l~~fk~~~ 653 (1325) T 5SZS_A 575 YTIVGALYVTWSEGNSITGVPYPVSGIREFSNLVLNNCTKYNIYDYVGTGIIRSSNQSLAGGITY-VSNSGNLLGFKNVS 653 (1325) T ss_dssp EEEEEEEEECCEEEEEEEECSSCCCSCSSCCBCCCSSCEEEEETTEEEEEEEEEECCCCCSCSEE-ECTTSCEEEEECTT T ss_pred EEEEEEEEEEecCCCeeEcccccccceeccceEEeCeeeeeEeCCccceeEEEeeceeeeCCEEE-EcCCCCEEEEEcCC Confidence 666677777765 5556666888888999999999999999999999999999999888888 78888888999999 Q sp|P0DTC2|SPIK 581 TLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAG-CLIGAEHVNN- 658 (1273) Q Consensus 581 tleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtrag-cligaehvnn- 658 (1273) ++++..|+||..+.++|+..|+. ..+.+ ..|++.-+ ..|.|+|-.| |..++++.-+ T Consensus 654 ~g~~Y~V~PC~~~~Q~VV~~g~~---vGalt--s~n~~~~~-----------------fnn~~~t~~~~~~s~~~~n~t~ 711 (1325) T 5SZS_A 654 TGNIFIVTPCNQPDQVAVYQQSI---IGAMT--AVNESRYG-----------------LQNLLQLPNFYYVSNGGNNCTT 711 (1325) T ss_dssp SSCEEEEECSSCCEEEEEETTEE---EEEEE--SSSSCCSS-----------------CCEEEEETTEEEEESCCSCCSC T ss_pred CCCEEEEEeCCCCCeEEEECCce---eEEEE--ceeceecC-----------------CCcceecCCcEEEecCCcccCC Confidence 99999999999999999998762 22222 22222111 3467778888 7777644433 Q sp|P0DTC2|SPIK 659 -SYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVD 737 (1273) Q Consensus 659 -syecdipigagicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvd 737 (1273) ..+| .|.|||+.+......|++. ....+ .. -....|.||+|||++|++|-++.+|.|.+|| T Consensus 712 ~v~ty---~~~giC~dg~~~~~~~~~~---~~~~~--------~~----~~t~~i~IP~nft~~v~~EyiQ~~~~kv~iD 773 (1325) T 5SZS_A 712 AVMTY---SNFGICADGSLIPVRPRNS---SDNGI--------SA----IITANLSIPSNWTTSVQVEYLQITSTPIVVD 773 (1325) T ss_dssp EEEEE---TTEEEETTSCEEECCCCBC---CCCCC--------CC----SSSEEEEEEEEEEEEEEEEEEECCCCCEEEC T ss_pred cchhc---ccceEeeCCCccccccccC---CCCCc--------ee----ceeeeEEccCceEEEEEEEEeeccCCCeEEe Confidence 3455 8999999998775555321 11111 00 1112799999999999999999999999999 Q sp|P0DTC2|SPIK 738 CTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVK---QIYKTPPIKDFGGFNFSQILPDPSKP-- 812 (1273) Q Consensus 738 ctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvk---qiyktppikdfggfnfsqilpdpskp-- 812 (1273) |.+|+||++.+|.+||.|||+||..+++||.+.+..++. |++..++ +.+..+.+..|++|||+.+||.+..+ T Consensus 774 C~~YVC~~~~~C~~ll~qYgs~C~~I~~al~~~~~~~~~---~~~~~~~~~~~~~~~~~~~~~~~~n~s~~l~~~~~~~~ 850 (1325) T 5SZS_A 774 CATYVCNGNPRCKNLLKQYTSACKTIEDALRLSAHLETN---DVSSMLTFDSNAFSLANVTSFGDYNLSSVLPQRNIRSS 850 (1325) T ss_dssp TTTTTSTTCTTHHHHGGGGHHHHHHHHHHHHHHHHHHHH---HHHHHCCBCHHHHHHTCGGGTGGGCCTTTSCCSCCSSS T ss_pred chhhccCCCHHHHHHHHHHhHHHHHHHHHHHHHHHHhhH---HHHhhhccCCcccccccccccCCCcchhccCCCCCCCc Confidence 999999999999999999999999999999999988754 4444444 34455678999999999999998754 Q sp|P0DTC2|SPIK 813 --SKRSFIEDLLFNKVTLADAGFIK-QYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFG 889 (1273) Q Consensus 813 --skrsfiedllfnkvtladagfik-qygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfg 889 (1273) +.||+||||||+||..+|.|+++ .|..|.+...+|||+|||.+||+.||||++++||+|.||++|++|....|||. T Consensus 851 ~~~~RS~IEDLLF~KV~t~glg~vd~~Y~~C~~g~~i~DL~CaQ~yNGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~ta- 929 (1325) T 5SZS_A 851 RIAGRSALEDLLFSKVVTSGLGTVDVDYKSCTKGLSIADLACAQYYNGIMVLPGVADAERMAMYTGSLIGGMVLGGLTS- 929 (1325) T ss_dssp CSCCCCHHHHHHHHHHC-------CCCGGGGGSCSSCCCHHHHHHTTTEEECCCSSCHHHHHHHHHHHHHTTTCCSBST- T ss_pred ccCcccHHHHHHCCceeecCCCccchhhHHccCCccHHHHhcccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhhchHH- Confidence 89999999999999999999997 99999999999999999999999999999999999999999999999999997 Q sp|P0DTC2|SPIK 890 AGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQN 955 (1273) Q Consensus 890 agaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqds--------------lsstasalgklqdvvnqn 955 (1273) |..||||+||.+|+||+|+||+||.||||+|||.||.|||.||.. ++++|+||.|+|||||++ T Consensus 930 ---aaaiPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~i~~~f~~vn~ai~qts~~~~tv~~Al~kiQ~VVN~q 1006 (1325) T 5SZS_A 930 ---AAAIPFSLALQARLNYVALQTDVLQENQKILAASFNKAINNIVASFSSVNDAITQTAEAIHTVTIALNKIQDVVNQQ 1006 (1325) T ss_dssp ---TCCCCHHHHHHHHHHTTSCCCCSSCHHHHHHHHHHHHHHHHHHHHHHC--------CTHHHHHHHHHHHHHHHHHHH T ss_pred ---hhhChHHHHHHHHhhHhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 556899999999999999999999999999999999999999988 445669999999999999 Q sp|P0DTC2|SPIK 956 AQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLG 1035 (1273) Q Consensus 956 aqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlg 1035 (1273) ++||++|++||+.|||||||.++||.+|||++||++|+||||+|||.+|++||+|+|.|++|+|+|+.||..|+.|||.. T Consensus 1007 ~~aL~~l~~qL~~nFgAISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~LA~qKinECVks 1086 (1325) T 5SZS_A 1007 GSALNHLTSQLRHNFQAISNSIQAIYDRLDSIQADQQVDRLITGRLAALNAFVSQVLNKYTEVRGSRRLAQQKINECVKS 1086 (1325) T ss_dssp HHHHHHHHHGGGCCCSSSCSCHHHHHTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1036 QSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVS--NGTHWFVTQRNFYEP 1112 (1273) Q Consensus 1036 qskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvs--ngthwfvtqrnfyep 1112 (1273) ||+|.+|||.|.|++|+||.||+|++|+|.+|+|.+-++.+++|.+|+++ ++..||++.|+- +...|++|.|++||| T Consensus 1087 QS~R~gFCGnG~Hi~S~~q~APnGi~F~H~~~~Pt~~~~v~a~~GlC~~~~~~~~~~~~~~v~~~~n~~~~~T~r~~y~P 1166 (1325) T 5SZS_A 1087 QSNRYGFCGNGTHIFSIVNSAPDGLLFLHTVLLPTDYKNVKAWSGICVDGIYGYVLRQPNLVLYSDNGVFRVTSRVMFQP 1166 (1325) T ss_dssp CCCCTTSSSSSEEEEEEEEEETTEEEEEEEEEEEEEEEEEEEESCEEETTTEEEEESSTTEEEEEETTEEEEEESSSCCC T ss_pred cCcCcCCCCCCeeeEEeeecCCCeEEEEEEeecccceeEEEEEEEEeecCCeeEEecCCCeEEEecCCEEEEeccccccC Confidence 99999999999999999999999999999999999999999999999995 789999996655 777999999999999 Q sp|P0DTC2|SPIK 1113 QIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPD-VDLGDISGINASVVNIQKEIDR------ 1185 (1273) Q Consensus 1113 qiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspd-vdlgdisginasvvniqkeidr------ 1185 (1273) ..||.++...-..|||...-++.++..+..|+.-.|++||+|+||++++.. .|+ ++..+|+.+.|+..||++ T Consensus 1167 r~~t~~d~v~~~sc~v~y~n~~~~~~~~~~p~~~d~~~el~~~~~~~~~~~~p~~-~~~~~n~t~lnl~~ei~~L~~~~~ 1245 (1325) T 5SZS_A 1167 RLPVLSDFVQIYNCNVTFVNISRVELHTVIPDYVDVNKTLQEFAQNLPKYVKPNF-DLTPFNLTYLNLSSELKQLEAKTA 1245 (1325) T ss_dssp BCCCGGGEEECSCCCSSSEEECTTGGGGTSTTCCCHHHHHHHC------------------------------------- T ss_pred cCCCccceEEeeccceEEEEccceecCCCCCCCCChHHHHHHHHHcCCCCCCCCC-CcccccceecchHHHHHHHHHHHh Confidence 999999999999999999999999999999999999999999999987655 455 378899999999999999 Q sp|P0DTC2|SPIK 1186 --------LNEVAKNLNESLIDLQELGKYEQYIKWPWY 1215 (1273) Q Consensus 1186 --------lnevaknlneslidlqelgkyeqyikwpwy 1215 (1273) |+++.|+||+++|||++|++||+||||--- T Consensus 1246 ~l~~~~~~l~~~i~~lN~s~idLe~L~~~e~YiKW~~~ 1283 (1325) T 5SZS_A 1246 SLFQTTVELQGLIDQINSTYVDLKLLNRFENLIKRMKQ 1283 (1325) T ss_dssp -------------------------------------- T ss_pred hHHHHHHHHHHHHHHHHHhccCHHHhcHHHHHHHHHHH Confidence 999999999999999999999999999643 No 14 >6IXB_B Spike glycoprotein; Alphacoronavirus, spike glycoprotein, STRUCTURAL PROTEIN; HET: MAN, NAG, BMA;{Human coronavirus 229E} Probab=100.00 E-value=8.3e-129 Score=1101.71 Aligned_cols=647 Identities=34% Similarity=0.594 Sum_probs=512.2 Template_Neff=4.700 Q sp|P0DTC2|SPIK 518 LHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSV 597 (1273) Q Consensus 518 lhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsv 597 (1273) ..+|..+.|-...++++.++||++|.-|.+|+|++++++..+...+.+ .|...-.++.++..++++..|+||....++| T Consensus 426 ~gv~~p~~~~~d~~~i~l~~Cv~YnIYG~tG~GvI~~~n~~~~~gl~~-~s~sG~l~~Fk~~~~g~~Y~V~PC~~~~q~V 504 (1116) T 6IXB_B 426 TGVPQPVEGVSSFMNVTLDKCTKYNIYDVSGVGVIRVSNDTFLNGITY-TSTSGNLLGFKDVTKGTIYSITPCNPPDQLV 504 (1116) T ss_dssp EECSSSCCCSCCCCCCCCSSCEEEEETTEEEEEEEEEECCCCCSCSEE-ECSSSCEEEEECTTTSCEEEEEESSCCEEEE T ss_pred EeecccccccccceeEEeCeeeeeEecCccceEEEEeeCceeeCcEEE-EeCCCCEEEEEcCCCCcEEEEeeCCCCCeEE Confidence 345555788888999999999999999999999999999999877777 7888888999999999999999999999999 Q sp|P0DTC2|SPIK 598 ITPGTNTSNQVAVLYQDVNCTEVPV-AIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIP----IGAGICA 672 (1273) Q Consensus 598 itpgtntsnqvavlyqdvnctevpv-aihadqltptwrvystgsnvfqtragcligaehvnnsyecdip----igagica 672 (1273) +..| +...+.++.... .+... .+ .+|.+ +++. +| ...|.-| .|.|||+ T Consensus 505 V~~~---~~vgalts~n~~-~~~~~~~~----~~~~~---------~~~~----~~------~~n~~~~~~~~~~~giC~ 557 (1116) T 6IXB_B 505 VYQQ---AVVGAMLSENFT-SYGFSNVV----ELPKF---------FYAS----NG------TYNCTDAVLTYSSFGVCA 557 (1116) T ss_dssp ECSS---SEEEEECSSCCC-CSSSSCCC----CCSSS---------CCBC----CS------CCCCCCEEEEETTEEEET T ss_pred EeCC---ceEEEEEccccc-cccccceE----Eecee---------eecc----CC------ccccccceeeeceeeEee Confidence 9988 345566676655 22211 11 12322 1211 23 3333334 4899999 Q sp|P0DTC2|SPIK 673 SYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNL 752 (1273) Q Consensus 673 syqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnl 752 (1273) .+....-.|| .+...++ +.-....|.||+|||++|++|-+..+|.|.+|||.+|+||++.+|.+| T Consensus 558 ~g~~~~~~~~---~~~~~~~------------~~~~t~~v~IP~nft~~v~~Eyiq~~~~kv~idC~~YVC~~~~~C~~l 622 (1116) T 6IXB_B 558 DGSIIAVQPR---NVSYDSV------------SAIVTANLSIPSNWTTSVQVEYLQITSTPIVVDCSTYVCNGNVRCVEL 622 (1116) T ss_dssp TSCEECCCCC---BCCCCCC------------CCSCCEEEEEECCCCCCCEEEEEECCCCCEEECHCCCCCSSCHHHHHH T ss_pred CCCeeeecce---eccCCCC------------ccccceeEEccCCeeeeeEEEEeeccCCCeEEechhhccCCCHHHHHH Confidence 8876533332 2211111 111122599999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 753 LLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSK----PSKRSFIEDLLFNKVTL 828 (1273) Q Consensus 753 llqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpsk----pskrsfiedllfnkvtl 828 (1273) |.|||+||..+++||.+.+..+|....+++...++-++.+.+..|++||||.+||.+.. ++.||+||||||+||.. T Consensus 623 l~qYgs~C~~I~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~n~s~~l~~~~~~~~~~~~RS~iEDlLF~KV~t 702 (1116) T 6IXB_B 623 LKQYTSACKTIEDALRNSAMLESADVSEMLTFDKKAFTLANVSSFGDYNLSSVIPSLPRSGSRVAGRSAIEDILFSKLVT 702 (1116) T ss_dssp HHHTHHHHHHHHHHHHHHHHHHHHHHHHHCCBCHHHHHTTCGGGGGGGCCTTTSCCCCSSCCC----CHHHHHHHHTCCC T ss_pred HHHhhhHHHHHHHHHHHHHhhhcHHHHHHHhcCccccccccccccCCccccccccCCCCCCCccccccHHHHHHccceee Confidence 99999999999999999999999999999999999999999999999999999998753 35799999999999999 Q sp|P0DTC2|SPIK 829 ADAGFIKQ-YGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFN 907 (1273) Q Consensus 829 adagfikq-ygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfn 907 (1273) +|.|++++ |.+|.+....|||+|||.+||+.||||.+++||++.||++|++|....|||. |..||||+||.+|+| T Consensus 703 ~glg~vd~dY~~C~~g~~i~DL~CaQ~ynGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~t~----aaaiPFa~~vq~RlN 778 (1116) T 6IXB_B 703 SGLGTVDADYKKCTKGLSIADLACAQYYNGIMVLPGVADAERMAMYTGSLIGGIALGGLTS----AASIPFSLAIQSRLN 778 (1116) T ss_dssp ------CCCGGGTSSSSSCCCHHHHHHHTTEEECCCTTCHHHHHHHHHHHHHHHSCCSCSS----SSCCCGGGHHHHHHH T ss_pred cCCCcccHHHHHhcCCccHHHHhcccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhhchhH----hhhChHHHHHHHHhh Confidence 99999988 9999999999999999999999999999999999999999999999999997 556899999999999 Q sp|P0DTC2|SPIK 908 GIGVTQNVLYENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAI 973 (1273) Q Consensus 908 gigvtqnvlyenqklianqfnsaigkiqds--------------lsstasalgklqdvvnqnaqalntlvkqlssnfgai 973 (1273) |+|+||+||.||||+||+.||.|||.||+. ++++|+||.|+|||||++++||++|++||+.||||| T Consensus 779 ~~~l~~~vL~~NQ~~iA~sFN~A~~~i~~~f~~~n~ai~qts~~~~t~~~Al~kiQ~VVN~~~~aL~~l~~qL~~nFgAI 858 (1116) T 6IXB_B 779 YVALQTDVLQENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQAI 858 (1116) T ss_dssp HHSCCCCSCCHHHHHHHHHHHHHHHHHHHHHC---------CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCSSSS T ss_pred hhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHhhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 999999999999999999999999999987 455669999999999999999999999999999999 Q sp|P0DTC2|SPIK 974 SSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFP 1053 (1273) Q Consensus 974 ssvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfp 1053 (1273) ||.++||.+|||++||++|+||||+|||.+|.+||+|+|.|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+| T Consensus 859 Sssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~lA~qKinECVksQS~R~gFCGnG~Hv~S~~ 938 (1116) T 6IXB_B 859 SSSIQAIYDRLDIIQADQQVDRLITGRLAALNVFVSHTLTKYTEVRASRQLAQQKVNECVKSQSKRYGFCGNGTHIFSLV 938 (1116) T ss_dssp CSCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCTSCCSCTTTSSSSEEEEEEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCcCcCCCCCCeeEEEee Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1054 QSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGV--FVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVI 1130 (1273) Q Consensus 1054 qsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregv--fvsngthwfvtqrnfyepqiittdntfvsgncdvvi 1130 (1273) |.||.|++|+|.+|+|.+-++.+++|.+|+++ ++..||++. |+.++.+|++|.|++|||..||..|...-..|||.. T Consensus 939 q~AP~Gi~F~H~~~~P~~~~~v~a~~GlC~~~~~~~~~~~~~~~~~~~~~~~~~T~r~~y~Pr~~t~~d~v~~~~c~v~y 1018 (1116) T 6IXB_B 939 NAAPEGLVFLHTVLLPTQYKDVEAWSGLCVDGRNGYVLRQPNLALYKEGNYYRITSRIMFEPRIPTIADFVQIENCNVTF 1018 (1116) T ss_dssp EEETTEEEEEEEEECCSSEEEEEECSCCCCSSSCCCCCSSTTBCCBCSSSSCBCCBSSCCCCCCCCGGGCCCCCCCCTTS T ss_pred ecCCCeEEEEEEeeccceeEEEEEEEEEeecCCceEEecCCceEeEeeCCEEEEeccccccCCCCCccceEEeecCceeE Confidence 99999999999999999999999999999995 789999887 888888999999999999999999999999999999 Q sp|P0DTC2|SPIK 1131 GIVNNTVYDPLQPELDSFKEELDKY-FKN--HTSPDVDLGDISGINASVVNIQKEIDR--------------LNEVAKNL 1193 (1273) Q Consensus 1131 givnntvydplqpeldsfkeeldky-fkn--htspdvdlgdisginasvvniqkeidr--------------lnevaknl 1193 (1273) .-++.++..+..|+.-.|++||+|+ +|+ |+-||.+ +..+|+.+.|+..||++ |+|+.|+| T Consensus 1019 ~~~~~~~~~~~~~~~~d~~~~~~~~~~~~~~~~~p~~~---~~~~n~t~lnl~~ei~~L~~~~~~l~~~~~~l~~~i~~l 1095 (1116) T 6IXB_B 1019 VNISRSELQTIVPEYIDVNKTLQELSYKLPNYTVPDLV---VEQYNQTILNLTSEISTLENKSAELNYTVQKLQTLIDNI 1095 (1116) T ss_dssp CCCCTTTHHHHSCCC----------------------------------------------------------------- T ss_pred EEcchhhcCCCCCCCCChHHHHHHHHhhCCCCCCCCCc---HHhccceeechHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 9999999999999999999999999 664 4556554 77899999999999999 99999999 Q sp|P0DTC2|SPIK 1194 NESLIDLQELGKYEQYIKWPW 1214 (1273) Q Consensus 1194 neslidlqelgkyeqyikwpw 1214 (1273) |+++|||++|++||+|||||| T Consensus 1096 N~s~idLe~L~~~e~YiKWPW 1116 (1116) T 6IXB_B 1096 NSTLVDLKWLNRVETYIKWPW 1116 (1116) T ss_dssp --------------------- T ss_pred HhcCccHHHhCeEEEEecCCC Confidence 999999999999999999999 No 15 >6CV0_A Spike protein; infectious bronchitis coronavirus, spike, pre-fusion; HET: NAG;{Infectious bronchitis virus} Probab=100.00 E-value=2.9e-125 Score=1068.92 Aligned_cols=651 Identities=31% Similarity=0.547 Sum_probs=514.4 Template_Neff=4.200 Q sp|P0DTC2|SPIK 524 VCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNK------KFLPFQQFGRDIADTTDAV--RDPQTLEILDITPCSFGGV 595 (1273) Q Consensus 524 vcgpkkstnlvknkcvnfnfngltgtgvltesnk------kflpfqqfgrdiadttdav--rdpqtleilditpcsfggv 595 (1273) +.|....++++.++||++|.-|.+|+|++++.+. -....+.+-.|.....|.. ++..++++..|+||....+ T Consensus 399 v~g~~d~snI~ld~CvdYNIYG~tG~GvItnvt~s~~~~~yl~~~Gl~ildtSg~idlf~~Kn~~~g~~Y~V~PC~~V~~ 478 (1105) T 6CV0_A 399 VITRHNYNNITLNTCVDYNIYGRTGQGFITNVTDSAVSYNYLADAGLAILDTSGSIDIFVVQGEYGLTYYKVNPCEDVNQ 478 (1105) T ss_dssp SCCSCCSCCCCCSSCEEEEETTEEEEEEEEECTTTTTTTTCSCSSCCCEECGGGCEEEEEECSSSSCEEEEEEECTTSSE T ss_pred cccccccceeEeCeeeeEEecCceeeEEEEecCCccccceeeccCCeEEEeCCCCceEEEEEcCCCCcEEEEEeCccCce Confidence 6777888999999999999999999999999655 3334444444444445544 4478999999999999999 Q sp|P0DTC2|SPIK 596 SVITPGTNTSNQVAVL-YQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN--SYECDIPIGAGICA 672 (1273) Q Consensus 596 svitpgtntsnqvavl-yqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnn--syecdipigagica 672 (1273) +++..|. +-|++| +....|.++..-.. .+++-.|| +++...+. ..+|+++.|.++|. T Consensus 479 Q~VV~~~---~iVG~LTs~n~t~s~~~~n~~----------------~i~~~~g~-~~~~~s~~~~~~~c~~~~y~~~ci 538 (1105) T 6CV0_A 479 QFVVSGG---KLVGILTSRNETGSQLLENQF----------------YIKITNGT-RRFRRSITENVANCPYVSYGKFCI 538 (1105) T ss_dssp EEEEETT---EEEEEEESSCSSCSEECSSSE----------------ECCCCCSS-SCCCCCCCCCBSCCCSCBCSSEEE T ss_pred eEEEECC---EEEEEEEEeCCCcccceeceE----------------EEEeeCCc-ceeeecccCccccCcceeecceEE Confidence 9998887 788888 88888877543111 26777888 77665543 68899999999998 Q sp|P0DTC2|SPIK 673 SYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNL 752 (1273) Q Consensus 673 syqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnl 752 (1273) -+... ++. +..+.+..|.+- +.-+...|.||+|||++|++|-+..+|.|.+|||.+|+||++.+|.+| T Consensus 539 ~~~g~----~~~--~~~~~l~~~~~p------~~~~~~~v~IP~nFtl~v~~EyiQt~~~kV~IDC~~YVC~~~~~C~~l 606 (1105) T 6CV0_A 539 KPDGS----IAT--IVPKQLEQFVAP------LLNVTENVLIPNSFNLTVTDEYIQTRMDKVQINCLQYVCGNSLDCRDL 606 (1105) T ss_dssp CSSSC----EEE--BCCCCCCCCCCC------CCCSSCCEEEESSCCCCEEEEEEECCCCEEEECHHHHHSCSCSSSHHH T ss_pred cCCCC----eee--eccceeeecccc------cceeeeEEEccCceeEeEEEEEEeecCCceEEEchhhccCCCHHHHHH Confidence 77651 111 111222223222 122566799999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 753 LLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQI-YKTPPIKDF--GGFNFSQILPDPSKPSKRSFIEDLLFNKVTLA 829 (1273) Q Consensus 753 llqygsfctqlnraltgiaveqdkntqevfaqvkqi-yktppikdf--ggfnfsqilpdpskpskrsfiedllfnkvtla 829 (1273) |.|||+||..+++||.+.+..+|.+..+++...|.- +++|-+..| |+||||.+||.|++|++||+||||||+||..+ T Consensus 607 l~qYgs~C~~I~~al~~~~~~e~~~~~~~~~~~~~~~~~~~~~~~~~~~~fN~s~ll~~~~~~~~RS~IEDLLF~KV~t~ 686 (1105) T 6CV0_A 607 FQQYGPVCDNILSVVNSIGQKEDMELLNFYSSTKPAGFNTPFLSNVSTGEFNISLLLTTPSSPRRRSFIEDLLFTSVESV 686 (1105) T ss_dssp HTTCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCSCCCCCCCSCSCCSSCCCTTTSCCSSCSSSCCSHHHHHHTTC--- T ss_pred HHHHHHHHHHHHHHHHHHHhHHhHHHHHHHHhcCCCccccccccccCCCCcceeeecCCCCCcCcccHHHHHhcCceeec Confidence 999999999999999999999999999999999766 677777645 78999999999999999999999999999999 Q sp|P0DTC2|SPIK 830 DAGFIKQYGDCLGDI--AARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFN 907 (1273) Q Consensus 830 dagfikqygdclgdi--aardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfn 907 (1273) |.|+-+.|..|.+.. .+|||+|||.+||+.||||++++||++.||++|++|....|||. |..|||||||.+|+| T Consensus 687 glg~d~~Y~~Ct~g~~~~i~DL~CAQyyNGimVLP~v~d~~~~amYTasL~g~m~~gg~ta----a~aiPFa~~vq~RlN 762 (1105) T 6CV0_A 687 GLPTDDAYKNCTAGPLGFLKDLACAREYNGLLVLPPIITAEMQTLYTSSLVASMAFGGITA----AGAIPFATQLQARIN 762 (1105) T ss_dssp ------CCCCTTSCCCCSSGGGHHHHHTTTEEEECCSSCTTSSTTHHHHHHHHHHHSSSCS----CSSCSSHHHHHHHHT T ss_pred CCCCcHHHHhccCCCCccHHHHhchhhcCcEEeeCCCCCHHHHHHHHHHHHHHHHhcchhH----hhhCcHHHHHHHHhc Confidence 999999999999996 79999999999999999999999999999999999999999994 667999999999999 Q sp|P0DTC2|SPIK 908 GIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKV 987 (1273) Q Consensus 908 gigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkv 987 (1273) ++|+||+||.||||+||+.||.|||.||+.+.++++||.|+|||||++++||++|++||+.|||||||.++||.+|||++ T Consensus 763 ~v~l~~~vL~~NQk~iA~sFN~A~~~i~~~f~~~~~Al~kiQ~VVN~q~~aL~~l~~qL~~nFgAISssi~dIy~rLd~l 842 (1105) T 6CV0_A 763 HLGITQSLLLKNQEKIAASFNKAIGRMQEGFRSTSLALQQIQHVVNKQNAILTETMASLNKNFGAISSLIQEIYQQLDAI 842 (1105) T ss_dssp TTTTCSCCCSSSSHHHHHHHHHHHHHHHHHTTSSCSHHHHHHHHHHHHHHHHTTTTTTSSSCCSSSCSCSTTTTTTSCHH T ss_pred hhhccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 988 EAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTY 1067 (1273) Q Consensus 988 eaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvty 1067 (1273) ||++|+||||||||.+|++||+|.+.+.+|.||++.||..|+.|||..||+|.+|||.|.|++|+||.||+|++|+|.+| T Consensus 843 eAdaQvDRLItGRL~aLna~vt~~~~~~~~v~~sr~LA~qKiNECVksQS~R~gFCGnG~Hv~S~~q~AP~Gi~F~H~~~ 922 (1105) T 6CV0_A 843 QANAQVDRLITGRLSSLSVLASAKQAEHIRVSQQRELATQKINECVKSQSIRYSFCGNGRHVLTIPQNAPNGIVFIHFSY 922 (1105) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCTTCCCCTTSSSSSSCCCEEEEECSSEEEEEEECC T ss_pred HHHHHhHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccCcccCCCCCCeEEEeeeeccCCeEEEEEEEe Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1068 VPAQEKNFTTAPAICHDG-----KAHFPR--EGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDP 1140 (1273) Q Consensus 1068 vpaqeknfttapaichdg-----kahfpr--egvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp 1140 (1273) +|.+-++.+++|.+|.++ .+..|+ .|+|+.+...|++|.|++|||..||.+|...-..|||...-+|+++..| T Consensus 923 ~P~~~~~v~a~~G~C~~~~~~~~~~~~~~~~~g~~~~~n~~~~~T~r~~y~Pr~~t~~d~v~i~sC~v~y~~~~~~~l~~ 1002 (1105) T 6CV0_A 923 TPDSFVNVTAIVGFCVKPANASQYAIVPANGRGIFIQVNGSYYITARDMYMPRAITAGDIVTLTSCQANYVSVNKTVITT 1002 (1105) T ss_dssp CCCCEEEECBCCCBCCCCSSSCCCEECCCTTSCCEEEETTEEEECCSSSCCCBCCCTTSCCEESCCCSSSCCCSSCCCCC T ss_pred ccCceeEEEEEEEEEecCcccccEEEEecCCCcEEEEECCEEEEeccccccCCCCCcccEEEeecCcceEEeCCcccccC Confidence 999999999999999997 588888 8999999899999999999999999999999999999999999999998 Q sp|P0DTC2|SPIK 1141 -LQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELG-KYEQYIKW 1212 (1273) Q Consensus 1141 -lqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelg-kyeqyikw 1212 (1273) ..|+.-.|+|||+|+|+++++.-.|+. +-.+|.++.|++.||++|+|+.|+||+| +||+||. |.|.|..- T Consensus 1003 ~~~pd~~Dfn~el~~~~~~~~~~~p~~~-~~n~n~t~LnLt~Ei~~l~~~i~~lN~s-~dLe~L~~~~~~~~~~ 1074 (1105) T 6CV0_A 1003 FVDNDDFDFNDELSKWWNDTKHELPDFD-KFNYTVPILDIDSEIDRIQGVIQGLNDS-VDIKQIEDKIEEILSK 1074 (1105) T ss_dssp CC------------------------------------------------------------------------ T ss_pred CCCcCCCChHHHHHHHHhcCCCCCCCcc-ccccccceechHHHHHHHHHHHHHHHhc-CCHHHHHHHHHHHHHH Confidence 579999999999999999976445563 3478889999999999999999999999 6999998 77877654 No 16 >6VV5_C Spike glycoprotein; glycoprotein, surface, receptor-binding, membrane fusion; HET: MAN, PAM, BMA, NAG;{Porcine epidemic diarrhea virus} Probab=100.00 E-value=1.7e-124 Score=1078.65 Aligned_cols=641 Identities=32% Similarity=0.536 Sum_probs=513.8 Template_Neff=4.600 Q sp|P0DTC2|SPIK 521 PATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITP 600 (1273) Q Consensus 521 patvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp 600 (1273) |..+.|-....+++.++||++|.-|.+|+|++++++..++..+. -.+.+.-.++.|+..++++..|+||....++|+.. T Consensus 614 ~~pv~g~~d~s~i~l~~Cv~YnIYG~tG~GvI~~t~~~~~~g~~-y~s~~G~l~~Fk~~~~~~~Y~V~PC~~~~Q~vV~~ 692 (1356) T 6VV5_C 614 PKPFEGVTDVSFMTLDVCTKYTIYGFKGEGIITLTNSSFLAGVY-YTSDSGQLLAFKNVTSGAVYSVTPCSFSEQAAYVD 692 (1356) T ss_dssp SSCCSSCSCCCBCCCSSEEEEEETTEEEEEEEEECSCCCSSCSE-EECTTSCEEEEECTTTCCEEEEECSSCEEEEEEET T ss_pred cCCcccccccceeeeCeeeeeEeCCceeeEEEEEcCceecCceE-EEcCCCCEEEEEcCCCCCEEEEEecccCceEEEEC Confidence 44466777788999999999999999999999999988876666 57777788899999999999999999999999987 Q sp|P0DTC2|SPIK 601 GTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPI----GAGICASYQT 676 (1273) Q Consensus 601 gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsyecdipi----gagicasyqt 676 (1273) |+ -|+++-. .|++. -+-+++-.|| +.|.+...+|+.|+ |.|||+.+.. T Consensus 693 g~----~Vg~lts-~n~~~--------------------~~~~~~~~~~---~~~~~~~~~c~~p~ltYg~~~ic~~g~~ 744 (1356) T 6VV5_C 693 DD----IVGVISS-LSSST--------------------FNSTRELPGF---FYHSNDGSNCTEPVLVYSNIGVCKSGSI 744 (1356) T ss_dssp TE----EEEEEES-CSCCS--------------------SSEEEEETTE---EEEESCCSCCSSEEEEETTEEEETTCCE T ss_pred CE----EEEEEEe-ecCCC--------------------CCceeecCce---eEecCCCccccceeEEeccceeecCCce Confidence 76 4555332 23321 1224555577 56667789999999 9999998776 Q sp|P0DTC2|SPIK 677 QTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQY 756 (1273) Q Consensus 677 qtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqy 756 (1273) -...+ +.. .... +.-....|.||+|||++|++|-+..+|.|.+|||.+|+||++.+|.+||.|| T Consensus 745 ~~~~~-~~~-------------~~~~--~~~~~~~v~IP~nft~~v~~Eyiq~~~~kv~idC~~YVC~~~~~C~~ll~qY 808 (1356) T 6VV5_C 745 GYVPS-QSG-------------QVKI--APTVTGNISIPTNFSMSIRTEYLQLYNTPVSVDCATYVCNGNSRCKQLLTQY 808 (1356) T ss_dssp EECCC-CCC-------------CCCC--CCCSSEEEEEEESCEEEEEEEEEECCCCCEEECHHHHHSSSCHHHHHHHGGG T ss_pred eeecC-ccC-------------CCCC--CcccceEEEecCCeEEEEEEEEEeecCCCeEEechhhccCCCHHHHHHHHHh Confidence 43222 110 0000 1122237899999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 757 GSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF--GGFNFSQILPDPS-------KPSKRSFIEDLLFNKVT 827 (1273) Q Consensus 757 gsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdf--ggfnfsqilpdps-------kpskrsfiedllfnkvt 827 (1273) |+||..+++||.+.+..+|-.......-..+.++.+-+..| |+|||+.+||.+. ++++||+||||||+||. T Consensus 809 gs~C~~I~~al~~~~~~e~~e~~~~~~~~~~~~~~~~~s~~~~~~~n~s~~l~~~~~~~~~~~~~~~RS~IEDLLF~KV~ 888 (1356) T 6VV5_C 809 TAACKTIESALQLSARLESVEVNSMLTISDEALQLATISSFNGDGYNFTNVLGVSVYDPASGRVVQKRSFIEDLLFNKVV 888 (1356) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHTTCSTTTSCCSSCCCTTTSCEEC--------CEECCHHHHHHHHHHC T ss_pred HHHHHHHHHHHHHHHhhhcHHHHHhHhhCHHHHhhceeecccCCCcceeeecccccCCCCCCCccCCcCHHHHHhccceE Confidence 99999999999999999855444444444556666666666 7899999999874 33789999999999999 Q sp|P0DTC2|SPIK 828 LADAGFI-KQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRF 906 (1273) Q Consensus 828 ladagfi-kqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrf 906 (1273) .+|.|++ +.|.+|.+...+|||+|||.+||+.||||++++||++.||++|++|....|||. |..||||+||.+|+ T Consensus 889 t~glg~vD~~Y~~C~~g~~i~DL~CaQ~yNGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~t~----aaaiPFa~~vq~Rl 964 (1356) T 6VV5_C 889 TNGLGTVDEDYKRCSNGRSVADLVCAQYYSGVMVLPGVVDAEKLHMYSASLIGGMVLGGFTS----AAALPFSYAVQARL 964 (1356) T ss_dssp -------CCCCTTTTSCSSCCCHHHHHHHTTEEECCCSSCHHHHHHHHHHHHHGGGCCSSSC----SSCCCHHHHHHHHH T ss_pred ecCCCCcchhHHHhcCCccHHHHhcccccCcEEEeCCCCCHHHHHHHHHHHHHHHHhcchhh----hhhChHHHHHHHHh Confidence 9999999 999999999999999999999999999999999999999999999999999997 44799999999999 Q sp|P0DTC2|SPIK 907 NGIGVTQNVLYENQKLIANQFNSAIGKIQDSL--------------SSTASALGKLQDVVNQNAQALNTLVKQLSSNFGA 972 (1273) Q Consensus 907 ngigvtqnvlyenqklianqfnsaigkiqdsl--------------sstasalgklqdvvnqnaqalntlvkqlssnfga 972 (1273) |++|+||+||.||||+||+.||.|||.||+.+ +++++||.|+|||||++++||++|++||+.|||| T Consensus 965 N~~~lt~~vL~~NQk~iA~sFN~A~~~i~~~f~~v~~ai~qts~~~~t~~~Al~kiQ~VVN~q~~aL~~l~~qL~~nFgA 1044 (1356) T 6VV5_C 965 NYLALQTDVLQRNQQLLAESFNSAIGNITSAFESVKEAISQTSKGLNTVAHALTKVQEVVNSQGAALTQLTVQLQHNFQA 1044 (1356) T ss_dssp HHHSCCCCCSSHHHHHHHHHHHHHHHHHHHHTTTGGGSCCTTTTSTTSHHHHHHHHHHHHHTTTTTHHHHHHGGGCCCSS T ss_pred hhhHhchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999886 8899999999999999999999999999999999 Q sp|P0DTC2|SPIK 973 ISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCG-KGYHLMS 1051 (1273) Q Consensus 973 issvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcg-kgyhlms 1051 (1273) |||.++||.+|||++||++|+||||+|||.+|.+||+|+|.|++|+|+|+.||..|+.|||..||+|.+||| .|.|++| T Consensus 1045 ISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vsq~l~~~~~v~~sr~LA~qKinECVksQS~R~gFCGnnG~Hi~S 1124 (1356) T 6VV5_C 1045 ISSSIDDIYSRLDILSADAQVDRLITGRLSALNAFVAQTLTKYTEVQASRKLAQQKVNECVKSQSQRYGFCGGDGEHIFS 1124 (1356) T ss_dssp SCSCHHHHHTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTSSSSSEEEEE T ss_pred HHHHHHHHHHHHHHHHHhhHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCccccCCCCCceEEEE Confidence 999999999999999999999999999999999999999999999999999999999999999999999999 7999999 Q sp|P0DTC2|SPIK 1052 FPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVS--N----G--THWFVTQRNFYEPQIITTDNTFV 1122 (1273) Q Consensus 1052 fpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvs--n----g--thwfvtqrnfyepqiittdntfv 1122 (1273) +||.||.|++|+|.+|+|.+-++.+++|.+|.++ ++..||++.|+- + + ..|++|.|++|||..||..+... T Consensus 1125 ~~q~APnGi~F~H~~~~P~~~~~v~a~~G~C~~~~~~~~~~~~~~~~~~~~~~n~~~~~~~~T~r~~y~Pr~~t~~d~v~ 1204 (1356) T 6VV5_C 1125 LVQAAPQGLLFLHTVLVPSDFVDVIAIAGLCVNDEIALTLREPGLVLFTHELQNHTATEYFVSSRRMFEPRKPTVSDFVQ 1204 (1356) T ss_dssp EEEEETTEEEEEEEEEECSEEEEEEECCCEEETTTEEEEESCTTEEEESCC-------CCEEEETTSCCCBCCCGGGEEE T ss_pred eccccCceEEEEEEeecccceeEEEEEEEEEeCCCceEEecCCceEEEeecccCCCCCeEEEeccccccCCCCCccceEE Confidence 9999999999999999999999999999999995 789999988766 3 1 58999999999999999999999 Q sp|P0DTC2|SPIK 1123 SGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHT---SPDVDLGDISGINASVVNIQKEIDRL------------- 1186 (1273) Q Consensus 1123 sgncdvvigivnntvydplqpeldsfkeeldkyfknht---spdvdlgdisginasvvniqkeidrl------------- 1186 (1273) -..|||...-++.++..+..|++..|++||+|+||+++ -||.++ ..+|+.+.|++.||++| T Consensus 1205 ~~sC~v~y~n~~~~~~~~~~p~~~df~~el~~~~~~~~~~~~p~~~~---~~~n~t~Lnl~~ei~~l~~~~~~l~~~~~~ 1281 (1356) T 6VV5_C 1205 IESCVVTYVNLTRDQLPDVIPDYIDVNKTLDEILASLPNRTGPSLPL---DVFNATYLNLTGEIADLEQRSESLRNTTEE 1281 (1356) T ss_dssp ESCCCTTSEEECTTTGGGTSTTCCCHHHHHHC------------------------------------------------ T ss_pred eecCeeEEEEcccccCCCCCCCCCChHHHHHHHHHcCCCCCCCCCCh---hcceeeeechHHHHHHHHHHHHHHhchHHH Confidence 99999999999999999999999999999999999884 455544 47999999999999997 Q sp|P0DTC2|SPIK 1187 -NEVAKNLNESLIDLQELGKYEQYIKWP 1213 (1273) Q Consensus 1187 -nevaknlneslidlqelgkyeqyikwp 1213 (1273) +|+.|+||+++|||++|++||.+-+|+ T Consensus 1282 l~~~i~~lN~s~idLe~Ln~~etla~~~ 1309 (1356) T 6VV5_C 1282 LQSLIYNINNTLVDLEWLNRVETGSGYI 1309 (1356) T ss_dssp ---------------------------- T ss_pred HHHHHHHHHHhccCHHHHcceeecccCC Confidence 899999999999999999999987765 No 17 >6M3W_B Spike glycoprotein,Spike glycoprotein; spike, post-fusion, SARS-CoV, coronavirus, glycoprotein; HET: NAG;{Human SARS coronavirus} Probab=100.00 E-value=1.8e-124 Score=1000.40 Aligned_cols=491 Identities=90% Similarity=1.349 Sum_probs=338.6 Template_Neff=3.600 Q sp|P0DTC2|SPIK 706 AYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQV 785 (1273) Q Consensus 706 aysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqv 785 (1273) |++...|.||+|||++|++|-+.++|.|.+|||.+|+||++.+|.+||.|||+||..+++||.+.+..+|....+++... T Consensus 1 ~~~~~~i~IP~nFtl~v~~EyiQ~~~~kV~IDC~~YVC~~~~rC~~LL~QYgs~C~~I~~aL~~~~~led~~~~~~~s~~ 80 (491) T 6M3W_B 1 AYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQV 80 (491) T ss_dssp CCCCEEEEEEEEEEEEECCCEEECCCCCCCCCHHHHTCSSCHHHHHHHTTSTTHHHHHHHHHHHHC-------------- T ss_pred CCCcceeeccCCeEEEEEEeeeeecCCceEEechhhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhHhHHHHHHHHHH Confidence 34567799999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 786 KQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLL 865 (1273) Q Consensus 786 kqiyktppikdfggfnfsqilpdpskpskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlppll 865 (1273) ++-++.|-+..|+|||||.++|.++++++||+||||||+||..+|.|+.+.|..|.+....|||+|||.|||+.||||.. T Consensus 81 ~~~~~~~~~~~~~~~N~s~~lp~~~~~~~RS~IEDLLF~KV~t~glG~~~dYk~Ct~g~~i~DL~CaQyyNGimVLP~v~ 160 (491) T 6M3W_B 81 KQMYKTPTLKYFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINARDLICAQKFNGLTVLPPLL 160 (491) T ss_dssp -------------------------------------------------------------------------------- T ss_pred hHHhccCcccccCCccccccCCCCCCCCCcCHHHHHhcCceeecCCchhHhHHHccCCccHHHhhcccccCCEEeeCCCC Confidence 99999999999999999999999988999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 866 TDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASAL 945 (1273) Q Consensus 866 tdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasal 945 (1273) ++||++.||++|++|....|||+|+|+|..||||+||.||+||+|+||+||.||||+|||.||.|++.||+.++.+++|| T Consensus 161 d~~~~a~YTasL~g~ma~gg~T~g~~saaaIPFa~~vq~RlN~valtt~VL~~NQk~iA~sFN~A~~~iq~g~~t~~~AL 240 (491) T 6M3W_B 161 TDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTAL 240 (491) T ss_dssp -----------------------------------------------------CCHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHhccccccCcchhccchHHHHHHHHhccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 946 GKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLA 1025 (1273) Q Consensus 946 gklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanla 1025 (1273) .|+|||||++++||++|++||+.|||||||.++||.+|||++||++|+||||+|||.+|.+||+|+|.|++|+|+|+.|| T Consensus 241 ~KiQ~VVN~q~~aL~~L~~qL~nnFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtq~l~~~~ev~~sr~LA 320 (491) T 6M3W_B 241 GKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLA 320 (491) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1026 ATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVT 1105 (1273) Q Consensus 1026 atkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvt 1105 (1273) ..|+.|||..||+|.+|||.|.|++|+||.||.|++|+|.+|+|.+-++.++.|.+|.++++..|++|+|+.|+..|++| T Consensus 321 ~qKiNECVKSQS~R~gFCGnGtHi~Si~q~APnGi~F~H~~~~Pt~~~~V~a~~GlC~~~~~~~~~~g~f~~~~~~~~iT 400 (491) T 6M3W_B 321 ATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFIT 400 (491) T ss_dssp HHHCCCCCSSCCCCBTSSSSSEEEEEEEEECSSEEEEEEEEEEEEEEEEEEEBSCCCSSSCCCEETTCCEECSSSCCEEC T ss_pred HHHHHHHHhccCcCcCcCCCCeeEEeccccCCCeEEEEEEEeCccceeEEEEeceEeecCceEeeeceeEEEcCcEEEEe Confidence 99999999999999999999999999999999999999999999999999999999999998999999999899999999 Q sp|P0DTC2|SPIK 1106 QRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDR 1185 (1273) Q Consensus 1106 qrnfyepqiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidr 1185 (1273) .|++|||..||..|...-..|||...-+|+++.+|++|++..|+|||++|+||+|+|+.++++++.+|+++.|++.||++ T Consensus 401 ~r~my~Pr~~t~~d~V~itsC~V~y~Nvn~~~~~~~~Pdy~df~del~~~~~N~T~p~~~l~~ld~fN~T~LNLt~EI~~ 480 (491) T 6M3W_B 401 QRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDR 480 (491) T ss_dssp CSSSCCCEECCSSSEECCSSCCCBCCCCCCSCCCCCCCCCCCHHHHHHHSCCCCCCCCCCCSHHHHCCCCCCCCCHHHHH T ss_pred ccccccCccCCCCceEEeecceeEEEEecccccCCCCCCCCCHHHHHHHHccCCCCCCCCCCCcccccccccchHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1186 LNEVAKNLNES 1196 (1273) Q Consensus 1186 lnevaknlnes 1196 (1273) |++++++||+| T Consensus 481 Lq~~i~~Ln~s 491 (491) T 6M3W_B 481 LNEVAKNLNES 491 (491) T ss_dssp HHHHHHHHHHC T ss_pred HHHHHHHHHcC Confidence 99999999986 No 18 >6U7K_C Spike glycoprotein; PEDV, Spike, Coronavirus, Fusion Protein; HET: MAN, BMA, NAG; 3.14A {Porcine epidemic diarrhea virus (strain CV777)} Probab=100.00 E-value=1.1e-122 Score=1065.47 Aligned_cols=641 Identities=33% Similarity=0.542 Sum_probs=505.8 Template_Neff=4.600 Q sp|P0DTC2|SPIK 521 PATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITP 600 (1273) Q Consensus 521 patvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp 600 (1273) |..+.|-....|++.++||++|..|.+|+|++++++..+...+ +..+.+...++.|+..++++..|+||..+.+.|+.. T Consensus 629 ~~pv~g~~d~sni~l~~CvdYnIYG~tG~GvI~~t~~~~~~g~-~y~s~~G~l~~Fk~~~~~~~Y~V~PC~~~~Q~vv~~ 707 (1399) T 6U7K_C 629 PKPLEGITDVSFMTLDVCTKYTIYGFKGEGIITLTNSSILAGV-YYTSDSGQLLAFKNVTSGAVYSVTPCSFSEQAAYVN 707 (1399) T ss_dssp SSCCCCSSCCCBCCCSSEEEEEETTEEEEEEEEEESCCCSSCS-EEECSSSSEEEEECTTTCCEEEEECSSCEEEEEEET T ss_pred cCCCccccccceeeeCeeEeeEeCCceeeEEEEEcCceeeCce-EEEcCCCCEEEEECCCCCCEEEEEeceeccEEEEEC Confidence 4446777888999999999999999999999999998887777 889999999999999999999999999887744443 Q sp|P0DTC2|SPIK 601 GTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPI----GAGICASYQT 676 (1273) Q Consensus 601 gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsyecdipi----gagicasyqt 676 (1273) |+ -|.++ ...|++. ..| +++-.|| +.|.+...+|+.|+ |.|||+.+.. T Consensus 708 ~~----~vg~l-ts~n~~~-------------------~~~-~~~~~~~---~~~s~~~~~c~~p~ltYg~~~ic~~g~~ 759 (1399) T 6U7K_C 708 DD----IVGVI-SSLSNST-------------------FNN-TRELPGF---FYHSNDGSNCTEPVLVYSNIGVCKSGSI 759 (1399) T ss_dssp TE----EEEEE-ESCSCCS-------------------SSE-EEECSSC---EEEESCCSCCSCEEEEETTEEEETTSCE T ss_pred CE----EEEEe-EeeeCCC-------------------CCC-eeecCce---eEecCCCcccccceEEecCceeeecCcc Confidence 22 23322 2223321 223 6778888 77888899999999 9999998876 Q sp|P0DTC2|SPIK 677 QTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQY 756 (1273) Q Consensus 677 qtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqy 756 (1273) -.-+|+ .+.. .|. . -....|.||+|||++|++|-+.++|.|.+|||.+|+||++.+|.++|.|| T Consensus 760 ~~~~~~-~~~~------~~~--~-------~~~~~v~IP~nft~~v~~Eyiq~~~~kV~VdCnvYVC~~N~rC~~lL~QY 823 (1399) T 6U7K_C 760 GYVPSQ-YGQV------KIA--P-------TVTGNISIPTNFSMSIRTEYLQLYNTPVSVDCATYVCNGNSRCKQLLTQY 823 (1399) T ss_dssp EECCCC-BCCC------CCC--C-------CSSSEEEEECSEEEEEEEEEEECCCCCEEECHHHHHHTTCHHHHHHHTTS T ss_pred ccccCc-cccc------ccc--c-------ccceeEEecCCeEEEEEEEEEeecCCCeEEEceEEEeCCCHHHHHHHHHH Confidence 433331 1111 110 0 11227899999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 757 GSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF--GGFNFSQILPDPS----K---PSKRSFIEDLLFNKVT 827 (1273) Q Consensus 757 gsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdf--ggfnfsqilpdps----k---pskrsfiedllfnkvt 827 (1273) |+||..+|.||.+.+-.++-...+....-.+.++++-+..| ++|||+.++|.+. + ++.||+||||||+||. T Consensus 824 gs~C~nIn~aL~~s~~le~~E~~~~~t~si~~l~~~~~s~~~~~d~N~s~ll~~~~~~p~~d~~~~~RSvIEDLLF~KV~ 903 (1399) T 6U7K_C 824 TAACKTIESALQLSARLESVEVNSMLTISEEALQLATISSFNGDGYNFTNVLGASVYDPASGRVVQKRSVIEDLLFNKVV 903 (1399) T ss_dssp TTHHHHHHHHHHHHHHHHHHHHHHHCCBCHHHHHHHTTSCCCCTTCCCHHHHCC------------CCCHHHHHHHHTTT T ss_pred HHHHHHHHHHHHHHHhhhhHHHHhhhccCHHHHhhhceeccCCCcceeeeeeccccCCCCCCCcCCcccHHHHHheeceE Confidence 99999999999998877644333334444555555555444 7899999887542 2 4789999999999999 Q sp|P0DTC2|SPIK 828 LADAGFI-KQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRF 906 (1273) Q Consensus 828 ladagfi-kqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrf 906 (1273) .+|.|++ +.|..|.+...+|||+|||.+||+.||||++++||++.||++|++|....|||. |..||||+||.+|+ T Consensus 904 t~glg~vD~~Y~~C~~g~~i~DL~CaQ~yNGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~ta----aaaiPFa~~vq~Rl 979 (1399) T 6U7K_C 904 TNGLGTVDEDYKRCSNGRSVADLVCAQYYSGVMVLPGVVDAEKLHMYSASLIGGMALGGITA----AAALPFSYAVQARL 979 (1399) T ss_dssp TTCCSSSCCCGGGGSSCSSCCCHHHHHHHTTEEECCCSSCHHHHHHHHHHHHGGGGCCCSSC----SSCCCHHHHHHHHH T ss_pred ecCCCCcchhhHHhcCCccHHHHhcccccCcEEEeCCCCCHHHHHhHHHHHHHHHHhcchhH----hhhChHHHHHHHHh Confidence 9999999 999999999999999999999999999999999999999999999999999997 66799999999999 Q sp|P0DTC2|SPIK 907 NGIGVTQNVLYENQKLIANQFNSAIGKIQDSLS--------------STASALGKLQDVVNQNAQALNTLVKQLSSNFGA 972 (1273) Q Consensus 907 ngigvtqnvlyenqklianqfnsaigkiqdsls--------------stasalgklqdvvnqnaqalntlvkqlssnfga 972 (1273) |++|+||+||.||||+||+.||.||+.||+.++ ++++||.|+|||||++++||++|++||+.|||| T Consensus 980 N~~~lt~~vL~~NQk~iA~sFN~A~~~iq~~f~~v~~ai~qts~~~~t~~~Al~kiQ~VVN~~~~aL~~l~~qL~~nFgA 1059 (1399) T 6U7K_C 980 NYLALQTDVLQRNQQLLAESFNSAIGNITSAFESVKEAISQTSKGLNTVAHALTKVQEVVNSQGSALNQLTVQLQHNFQA 1059 (1399) T ss_dssp HTTSCCCCCSSTHHHHHHHHHHHHHHHHHTTTTCCGGGCCGGGGSTTSHHHHHHHHHHHHHHTTHHHHHHHHTTSCCTTS T ss_pred hhhHHchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 999999999999999999999999999999866 899999999999999999999999999999999 Q sp|P0DTC2|SPIK 973 ISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCG-KGYHLMS 1051 (1273) Q Consensus 973 issvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcg-kgyhlms 1051 (1273) |||.++||++|||++||++|+||||+|||.+|.+||+|+|+|++|+|+|+.||..|+.|||..||+|.+||| .|.|++| T Consensus 1060 ISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~LA~qKinECVksQS~R~gFCGnnG~Hv~S 1139 (1399) T 6U7K_C 1060 ISSSIDDIYSRLDILSADVQVDRLITGRLSALNAFVAQTLTKYTEVQASRKLAQQKVNECVKSQSQRYGFCGGDGEHIFS 1139 (1399) T ss_dssp SCSCHHHHHTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTTTSSSEEEEE T ss_pred HHHHHHHHHHHHHHHHHhhHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCccccCCCCCceEEEE Confidence 999999999999999999999999999999999999999999999999999999999999999999999999 7999999 Q sp|P0DTC2|SPIK 1052 FPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNG--------THWFVTQRNFYEPQIITTDNTFV 1122 (1273) Q Consensus 1052 fpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvsng--------thwfvtqrnfyepqiittdntfv 1122 (1273) +||.||.|++|+|.+|+|.+-++.+++|.+|+++ ++..||++.|+-.. ..|++|.|++|||..||.++... T Consensus 1140 ~~q~APnGi~F~H~~~~P~~~~~v~a~~G~C~~~~~~~~~~~~~~v~~~~~~~~~~~~~~~~T~r~~y~Pr~~t~~d~v~ 1219 (1399) T 6U7K_C 1140 LVQAAPQGLLFLHTVLVPGDFVNVLAIAGLCVNGEIALTLREPGLVLFTHELQTYTATEYFVSSRRMFEPRKPTVSDFVQ 1219 (1399) T ss_dssp EEEEETTEEEEEEEEEEESCEEEEEECCCEEETTTEEEEESCTTEEEEESCTTSSSCSCCEEEESSSCCCBCCCTTTEEE T ss_pred eccccCceEEEEEEEeccCceEEEEEEEEEEecCCeeEEecCCceEEEeeCCcccccceEEEeccccccCCCCCccceEE Confidence 9999999999999999999999999999999995 78999999766532 48999999999999999999999 Q sp|P0DTC2|SPIK 1123 SGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHT---SPDVDLGDISGINASVVNIQKEIDRLNE----------- 1188 (1273) Q Consensus 1123 sgncdvvigivnntvydplqpeldsfkeeldkyfknht---spdvdlgdisginasvvniqkeidrlne----------- 1188 (1273) -..|||...-++.++..+..|++-.|++||+|+||+++ .||.++ ..+|+.+.|++.||++|++ T Consensus 1220 ~~~c~v~y~~~~~~~~~~~~p~~~d~~~~l~~~~~~~~~~~~p~~~~---~~~n~t~lnl~~ei~~l~~~~~~l~~~~~~ 1296 (1399) T 6U7K_C 1220 IESCVVTYVNLTSDQLPDVIPDYIDVNKTLDEILASLPNRTGPSLPL---DVFNATYLNLTGEIADLEQRSESLRNTTEE 1296 (1399) T ss_dssp ESSCCTTSEEECTTTHHHHSTTC--------------------------------------------------------- T ss_pred eecCeeEEEEcCcccCCCCCCCCCChHHHHHHHHHcCCCCCCCCCCh---hcceeeeechHHHHHHHHHHHHHHHhHHHH Confidence 99999999999999999999999999999999999884 455543 4789999999999999877 Q sp|P0DTC2|SPIK 1189 ---VAKNLNESLIDLQELGKYEQYIKWP 1213 (1273) Q Consensus 1189 ---vaknlneslidlqelgkyeqyikwp 1213 (1273) +.|+||+++|||++|++||.|+||- T Consensus 1297 ~~~~i~~lN~s~idLe~L~~~et~~~~~ 1324 (1399) T 6U7K_C 1297 LRSLINNINNTLVDLEWLNRVETGSGYI 1324 (1399) T ss_dssp ---------------------------- T ss_pred HHHHHHHHHHhccCHHHHcceeecCccC Confidence 9999999999999999999999993 No 19 >6BFU_C Spike protein; coronavirus spike glycoprotein, porcine deltacoronavirus; HET: MAN, BMA, NAG; 3.5A {Porcine deltacoronavirus} Probab=100.00 E-value=3.5e-119 Score=1017.49 Aligned_cols=746 Identities=30% Similarity=0.489 Sum_probs=605.1 Template_Neff=4.700 Q sp|P0DTC2|SPIK 267 VGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQ-PTESIVRFPNITNLCPFGEVFNAT 345 (1273) Q Consensus 267 vgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvq-ptesivrfpnitnlcpfgevfnat 345 (1273) +.|...-..|+ |-.||+|.|.+.|--.|+..-||.-.+|....|.|..++..+. ..+.+|..|+..+....- .|.+ T Consensus 240 va~a~~tdVL~-~f~ngtIq~viyCD~sp~~~LaCqy~tfnfsDGFYp~t~~~~v~~~ktfV~lP~~~nhT~v~--ln~t 316 (1024) T 6BFU_C 240 FALANLTDTLI-TLTNTTISQITYCDKSVVDSIACQRSSHEVEDGFYSDPKSAVRARQRTIVTLPKLPELEVVQ--LNIS 316 (1024) T ss_dssp EEEEEEEEEEE-EEETTEEEEEEETTTCHHHHHHHHTTSSSCCSEEEECGGGCBCCSEEEEECSCCCCCEEEEE--EEEE T ss_pred EEEeeccchhe-eeeCCcccEEEECCCChhcccchhccccccCCCccCCCccccccCCceEEEcCCCCceeEEE--EEEE Confidence 34444444555 8899999999999977999999999999999999999988764 556899999987765421 1111 Q sp|P0DTC2|SPIK 346 RFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKL 425 (1273) Q Consensus 346 rfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynykl 425 (1273) -+...-+ ... +++..|+ -+..|..+ ++ +.+ T Consensus 317 f~n~s~a---g~v----------------~~i~~~~-----~s~yCV~n----s~----------------------ft~ 346 (1024) T 6BFU_C 317 AHMDFGE---ARL----------------DSVTING-----NTSYCVTK----PY----------------------FRL 346 (1024) T ss_dssp EEEETTE---EEE----------------EEEEETT-----BSEEECCS----SE----------------------EEE T ss_pred EeecCCC---Ccc----------------eeEEEec-----cceeEecC----Ce----------------------EEE Confidence 1110000 000 0011111 11122211 00 111 Q sp|P0DTC2|SPIK 426 PDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERD----------ISTEIYQAGSTPCNGVEGFNCYFPLQSY 495 (1273) Q Consensus 426 pddftgcviawnsnnldskvggnynylyrlfrksnlkpferd----------isteiyqagstpcngvegfncyfplqsy 495 (1273) ..+|.. |+.|.+ .+ ..--||..+ ++-.+.+.| |-++.... T Consensus 347 ~~~f~~--------------g~sy~~----~~-~~sCpFr~e~INNyL~FnSlCvSl~~gg-----------Ck~~v~~~ 396 (1024) T 6BFU_C 347 ETNFMC--------------TGCTMN----LR-TDTCSFDLSAVNNGMSFSQFCLSTESGA-----------CEMKIIVT 396 (1024) T ss_dssp EEECCE--------------ESSEEE----EE-ESSSSSCHHHHTTTCEEEEEEEESSCCS-----------EEEEEEEE T ss_pred EEEEee--------------ccCccc----cc-CCCCCCChhhccCCCccCeEEEEeCCCc-----------eeeEEEEE Confidence 111110 001111 00 011122211 111111222 54444432 Q sp|P0DTC2|SPIK 496 GFQPTNGVGYQPYRVVVLSFE---LLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADT 572 (1273) Q Consensus 496 gfqptngvgyqpyrvvvlsfe---llhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadt 572 (1273) . ...|++++.|.++++ ......++|. +..++++.++||++|.-|.+|+|+++++|..+...+.+ .|...- T Consensus 397 ~-----~~sy~~~~~VyVt~s~Gsri~g~~~~~~-~d~s~i~l~~CvdYnIYG~tG~GvI~~~n~~~~~Gl~~-~s~sG~ 469 (1024) T 6BFU_C 397 Y-----VWNYLLRQRLYVTAVEGQTHTGTTSVHA-TDTSSVITDVCTDYTIYGVSGTGIIKPSDLLLHNGIAF-TSPTGE 469 (1024) T ss_dssp S-----SSEEECSCCEEEEEEEEEEEEECSSSSC-CCTTCCCCSSEEEEEETTEEEEEEEEECSCCCCSCSEE-ECTTSC T ss_pred E-----EeeeeceeEEEEEecCCCeeeccCCccC-CCCCceeeceeeeEEecCeeeeEEEecCCEEeeCcEEE-EcCCCC Confidence 1 123678888888877 3334445664 56699999999999999999999999999999989988 899999 Q sp|P0DTC2|SPIK 573 TDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIG 652 (1273) Q Consensus 573 tdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragclig 652 (1273) .++.+++.++++..|+||....++|+..|.- |+ ++...| +++++.|++..||..+ T Consensus 470 L~~Fk~~~~g~~Y~V~PC~~v~Q~vV~~g~i----VG-~lts~n--------------------~t~s~~f~~~~~~~~~ 524 (1024) T 6BFU_C 470 LYAFKNITTGKTLQVLPCETPSQLIVINNTV----VG-AITSSN--------------------STENNRFTTTIVTPTF 524 (1024) T ss_dssp EEEEEETTTTEEEEEECSSCCEEEEEETTEE----EE-EEESCG--------------------GGCCTTCSEEEEETTE T ss_pred eeEEEeCCCCCEEEEeeCCCCcEEEEECCEE----EE-EEEccC--------------------CCCCccccceeEecee Confidence 9999999999999999999877765544433 22 122222 3478889999999999 Q sp|P0DTC2|SPIK 653 AEHVNN-SYECDIPIGA----GICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEIL 727 (1273) Q Consensus 653 aehvnn-syecdipiga----gicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteil 727 (1273) +.+.++ ..+|+.|+|. |||+.+..-...|+.. + ..-.+...++.|.||+|||++|++|-+ T Consensus 525 ~~~s~~~~~~C~~p~~syg~~giC~dg~~~~~~~~~~----------~-----~p~~~~~vt~~i~IP~nft~~v~~Eyi 589 (1024) T 6BFU_C 525 FYSTNATTFNCTKPVLSYGPISVCSDGAIVGTSTLQN----------T-----RPSIVSLYDGEVEIPSAFSLSVQTEYL 589 (1024) T ss_dssp EEEECCSCCCCSCEEEEETTEEEETTSCEEECCCEEC----------C-----CSCSSCCCCSSEEEEEEEEEEEEEEEE T ss_pred eeecCCCccccccceeeccceeEccCCccccceeeec----------c-----CCceeeccCeEEEccCceEeeEEEeEE Confidence 999875 7999999999 9999886633322110 0 111123344589999999999999999 Q sp|P0DTC2|SPIK 728 PVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFG-GFNFSQIL 806 (1273) Q Consensus 728 pvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfg-gfnfsqil 806 (1273) ..+|.|.+|||.+|+||++.+|.+||.|||+||..+++||.+.+..+|.+..+++...++-++.+-|..|+ +||||.+| T Consensus 590 q~~~~kv~idC~~YVC~~~~~C~~ll~qYg~~C~~I~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~n~s~~l 669 (1024) T 6BFU_C 590 QVQAEQVIVDCPQYVCNGNSRCLQLLAQYTSACSNIEAALHSSAQLDSREIINMFQTSTQSLQLANITNFKGDYNFSSIL 669 (1024) T ss_dssp ECCCCEEEECHHHHHHTTBHHHHHHHTTSTTHHHHHHHHHHHHHHHHHHHHHHHTCEEHHHHHHTCGGGGCSSSCCTTTS T ss_pred eeecCceEEecchhhcCCCHHHHHHHHHhhhHHHHHHHHHHHHHhhhhHHHHHHHhhCcccccccccccCCCCccchhhc Confidence 99999999999999999999999999999999999999999999999999999999999999998888884 69999999 Q sp|P0DTC2|SPIK 807 PDPSKPSKRSFIEDLLFNKVTLADAGFI-KQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSG 885 (1273) Q Consensus 807 pdpskpskrsfiedllfnkvtladagfi-kqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsg 885 (1273) |.+. +.||+||||||+||..+|.|++ +.|.+|.+....|||+|||.+||+.||||.+++||++.||++|++|....| T Consensus 670 ~~~~--~~RS~iEDlLF~KV~t~glg~vD~~Y~~C~~g~~i~DL~CaQ~ynGi~VLP~v~~~~~~a~YT~sl~g~m~~gg 747 (1024) T 6BFU_C 670 TTRI--GGRSAIEDLLFNKVVTSGLGTVDQDYKSCSRDMAIADLVCSQYYNGIMVLPGVVDAEKMAMYTGSLTGAMVFGG 747 (1024) T ss_dssp CSST--TCCCHHHHHCCCCCCC------CCCGGGGGSTTGGGSHHHHHHTTTEEEECCSSCHHHHHHHHHHHHHGGGCCS T ss_pred CCCC--CCccHHHHHHcceeeecCCCccchHHHhccCCccHHHHhhccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhhc Confidence 8774 7999999999999999999999 899999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 886 WTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSS--------------TASALGKLQDV 951 (1273) Q Consensus 886 wtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslss--------------tasalgklqdv 951 (1273) ||. |..||||+||.+|+|++|+||+||.||||+|||.||.|||.||+.+++ +++||.|+||| T Consensus 748 ~ta----aaaiPFa~~vq~RlN~~~lt~~vL~~NQ~~iA~sFN~A~~~i~~~f~~v~~ai~qts~~~~t~~~Al~kiQ~V 823 (1024) T 6BFU_C 748 LTA----AAAIPFATAVQARLNYVALQTNVLQENQKILAESFNQAVGNISLALSSVNDAIQQTSEALNTVAIAIKKIQTV 823 (1024) T ss_dssp SSS----SCCCCHHHHHHHHHHHHTTSSSCCSTTHHHHHHHHHHHHHHHHHHHHTTCCSCCTTCHHHHHHHHHHHHHHHH T ss_pred HHH----hHhChHHHHHHHHhhhhhhchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 997 556899999999999999999999999999999999999999988555 99999999999 Q sp|P0DTC2|SPIK 952 VNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSE 1031 (1273) Q Consensus 952 vnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmse 1031 (1273) ||++++||++|++||+.|||||||.++||.+|||++||++|+||||+|||.+|.+||+|+|.|++|+|+|+.||..|+.| T Consensus 824 VN~~~~aL~~l~~qL~~nFgAISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~lA~qKinE 903 (1024) T 6BFU_C 824 VNQQGEALSHLTAQLSNNFQAISTSIQDIYNRLEEVEANQQVDRLITGRLAALNAYVTQLLNQMSQIRQSRLLAQQKINE 903 (1024) T ss_dssp HHTTTHHHHHHHHGGGCCCSSSCSCHHHHHHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1032 CVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVF-VSNGTHWFVTQRNF 1109 (1273) Q Consensus 1032 cvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvf-vsngthwfvtqrnf 1109 (1273) ||..||+|.+|||.|.|++|+||.||.|++|+|.+|+|.+-++.+++|.+|+++ ++..|+.|.+ +.+...|++|.|++ T Consensus 904 CVksQS~R~gFCGnG~Hv~S~~q~AP~Gi~F~H~~~~P~~~~~v~a~~G~C~~~~~~~~~~~g~~~~~~n~~~~~T~r~~ 983 (1024) T 6BFU_C 904 CVKSQSPRYGFCGNGTHIFSLTQTAPNGIFFMHAVLVPNKFTRVNASAGICVDNTRGYSLQPQLILYQFNNSWRVTPRNM 983 (1024) T ss_dssp CCCSCCCCTTTSSSSEEEEEEEEEETTEEEEEEEEEEEEEEEEECCBCEEEETTTEEEEECTTEEEEEETTEEEEEESSS T ss_pred HHhccCCCcCCCCCCeeEEEeeecCCCeEEEEEEEecccceeEEEEEEEEeecCCceEEeCCceEEEeeCCEEEEecccc Confidence 999999999999999999999999999999999999999999999999999995 7888888866 78778999999999 Q sp|P0DTC2|SPIK 1110 YEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSF 1148 (1273) Q Consensus 1110 yepqiittdntfvsgncdvvigivnntvydplqpeldsf 1148 (1273) |||..||..|...-..|||...-+|+++..+..|++-.| T Consensus 984 y~Pr~~t~~d~v~~~sC~v~y~n~~~~~~~~~~p~~~D~ 1022 (1024) T 6BFU_C 984 YEPRLPRQADFIQLTDCSVTFYNTTAANLPNIIPDIIDV 1022 (1024) T ss_dssp CCCBCCCGGGEEEESSCCTTSEEECTTTGGGTSTTCCCT T ss_pred ccCCCCCcccEEEcccceeEEEECCcccCCCCCCCCCCC Confidence 999999999999999999999999999999988886544 No 20 >6B3O_B Spike glycoprotein; Coronavirus, membrane fusion, MHV, SARS; 4.1A {Murine coronavirus} Probab=100.00 E-value=7.3e-117 Score=954.95 Aligned_cols=497 Identities=42% Similarity=0.726 Sum_probs=333.3 Template_Neff=3.300 Q sp|P0DTC2|SPIK 703 NSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVF 782 (1273) Q Consensus 703 nsvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevf 782 (1273) .....++..|.||+|||++|++|-+.++|.|.+|||.+|+||++.+|.+||.|||+||..+++||.|.+..+|....+++ T Consensus 45 ~~~~~~~~~isIP~nFtlsv~~EyiQt~~~kVsIDC~~YVCngn~rC~~LL~QYgs~C~~I~~aL~~v~~~~d~~~~~~~ 124 (605) T 6B3O_B 45 VQSVDGLYEMQIPTNFTIGHHEEFIQTRSPKVTIDCAAFVCGDNTACRQQLVEYGSFCVNVNAILNEVNNLLDNMQLQVA 124 (605) T ss_dssp -CBCSCCCCEEEEEEEEEEEEEEEEECSCCCCCCCHHHHHTCSCHHHHHHHTTSCSHHHHHHHHHHHC------------ T ss_pred CcccCcceEEEecCceEeEEEEEEeeccCCCeEEehhhhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 45778888999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 783 AQVKQIYKTP-----PI-KDFGGFNFSQILPD-----------PSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIA 845 (1273) Q Consensus 783 aqvkqiyktp-----pi-kdfggfnfsqilpd-----------pskpskrsfiedllfnkvtladagfikqygdclgdia 845 (1273) ...++.+..+ .| ...|+||||.++|. |++|+.||+|||||||||..+|.|+.+.|..|.+... T Consensus 125 ~~~~~~~~~s~~~~~~i~~~~g~fN~s~ll~~~~~~~~~~~~~~~~~~~RSaIEDLLFnKVvt~glGt~~dYk~Ct~g~~ 204 (605) T 6B3O_B 125 SALMQGVTISSRLPDGISGPIDDINFSPLLGCIGSTCAEDGNGPSAIRGRSAIEDLLFDKVKLSDVGFVEAYNNCTGGQE 204 (605) T ss_dssp -------------------------------------------------------------------------------- T ss_pred HHHhccCcccccCCCCCCCCCCCccchhhcccccCCcccCCCCCCcCCCccHHHHHHCCceEecCCchhHHHHhccCCcc Confidence 9998888764 22 33456999999986 7778899999999999999999999999999999999 Q sp|P0DTC2|SPIK 846 ARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIAN 925 (1273) Q Consensus 846 ardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklian 925 (1273) .|||+|||.|||+.||||..++||++.||++|.+|....|||. |..||||+||.||+||+|+||+||.||||+||| T Consensus 205 iaDL~CAQyyNGImVLPpVvda~~~amYTaSL~G~ma~gG~Ta----AaaIPFa~~vQaRlNyvaltt~VLq~NQk~iAn 280 (605) T 6B3O_B 205 VRDLLCVQSFNGIKVLPPVLSESQISGYTTGATAAAMFPPWSA----AAGVPFSLSVQYRINGLGVTMNVLSENQKMIAS 280 (605) T ss_dssp ----------------------------------------------------------------------------CHHH T ss_pred hHHHhCccccCcEEeeCCCCCHHHHHHHHHHHHHHhhcccchh----cccCchHHHHHHHhcccccchHHHHHHHHHHHH Confidence 9999999999999999999999999999999999999999997 556899999999999999999999999999999 Q sp|P0DTC2|SPIK 926 QFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQ 1005 (1273) Q Consensus 926 qfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslq 1005 (1273) .||.|+|.||+.++++++||.|+|||||++++||++|++||+.|||||||.++||.+|||++||++|+||||||||.+|. T Consensus 281 sFN~AignIq~gf~tta~AL~KIQdVVN~q~~aL~~Lt~QL~nNFgAISSSI~dIy~RLD~leAdaQVDRLItGRL~aLN 360 (605) T 6B3O_B 281 AFNNALGAIQDGFDATNSALGKIQSVVNANAEALNNLLNQLSNRFGAISASLQEILTRLEAVEAKAQIDRLINGRLTALN 360 (605) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1006 TYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG 1085 (1273) Q Consensus 1006 tyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg 1085 (1273) +||+|+|.+++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+||.||.|++|+|.+|+|.+-++.++.|.+|.++ T Consensus 361 afVtQ~L~~~~eVr~sr~LA~qKINECVKSQS~RygFCGnGtHifSi~q~APnGi~FlH~~y~Pt~~~~V~A~~GlCv~~ 440 (605) T 6B3O_B 361 AYISKQLSDSTLIKVSAAQAIEKVNECVKSQTTRINFCGNGNHILSLVQNAPYGLYFIHFSYVPISFTTANVSPGLCISG 440 (605) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHTTTSSCCCCBSCSSSSEEEEEEEEEETTEEEEEEEEEEEEEEEEECCBSCEECSS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCccCcCCCCeEEEEeeeccCCeEEEEEEEecccceEEEEEEeeEEecC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999995 Q sp|P0DTC2|SPIK 1086 -KAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDV 1164 (1273) Q Consensus 1086 -kahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdv 1164 (1273) ++..|+.|+|+.+..+|++|.|++|+|..+|..|...-..|||...-++.++..|..|+.-.|++||+++|+|+++.-. T Consensus 441 ~~~~~~~~g~f~~~n~~~~iT~r~my~Pr~~t~~dfV~itSC~V~Y~Nvt~t~lp~viPdyiDfn~eLee~~~n~t~t~P 520 (605) T 6B3O_B 441 DRGLAPKAGYFVQDDGEWKFTGSSYYYPEPITDKNSVIMSSCAVNYTKAPEVFLNTSIPNPPDFKEELDKWFKNQTSIAP 520 (605) T ss_dssp SCEEEESSEEEEEETTEEEEEESSSCCCEECCTTSEEEESCSCCEEEECCCCCCCCCCCCCSCHHHHHTTTCCCCCCCCC T ss_pred CceEEecCeEEEeeCCeEEEeccccccCCCCCccceEEeeccccEEEecccccCCCCCCCCCChHHHHHHHHhcCCCCCC Confidence 7999999999999889999999999999999999999999999999999999999999999999999999999987444 Q sp|P0DTC2|SPIK 1165 DLG-DISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1165 dlg-disginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) |+. |+.-+|+++.|+..||++|+++.|+||+++|||..- T Consensus 521 dl~~~ld~fN~T~LNLt~EI~~Lq~~i~~LN~s~IDL~~~ 560 (605) T 6B3O_B 521 DLSLDFEKLNVTLLDLTYEMNRIQDAIKKLNESYINLIKR 560 (605) T ss_dssp CCCCCGGGCCCCCCCCHHHHHHHHHHHHHTTTC------- T ss_pred CcCCCHHHccccccchHHHHHHHHHHHHHHHHHHHHHHHH Confidence 443 688999999999999999999999999999999754 No 21 >6PZ8_A S protein, G2 heavy chain; MERS-CoV, coronavirus, DPP4, receptor-binding, membrane; HET: MAN, NAG, BMA; 4.19A {Middle East respiratory syndrome-related coronavirus} Probab=100.00 E-value=8.5e-112 Score=897.44 Aligned_cols=445 Identities=43% Similarity=0.743 Sum_probs=424.4 Template_Neff=3.100 Q sp|P0DTC2|SPIK 694 AYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVE 773 (1273) Q Consensus 694 aytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiave 773 (1273) .|++.+-. ..+.+++..|.||+||||+|++|.++++|.|.+|||.+|+||++.+|.+||.|||+||..+|++|.|.+.+ T Consensus 12 ~~~~p~~~-~~~~~~~~~i~IP~nFtl~v~~EyiQt~~~kV~IDC~~YVC~~~~~C~~LL~QYgs~C~~I~~aL~~~~~~ 90 (472) T 6PZ8_A 12 AFNHPIQV-DQLNSSYFKLSIPTNFSFGVTQEYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANLR 90 (472) T ss_dssp CCCCCEEC-CCCCTTEEEEEECCEEEEEEEEEEEECCCCCEEECHHHHHSSSCHHHHHHHGGGHHHHHHHHHHHHHHHHH T ss_pred eccCCcee-ccccCCCeeEEeccceEEEEEEEEEEecCCceEEechhhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 56666554 67788899999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 774 QDKNTQEVFAQVKQIYKTPPIKDF-GGFNFSQILPDPS---KPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDI--AAR 847 (1273) Q Consensus 774 qdkntqevfaqvkqiyktppikdf-ggfnfsqilpdps---kpskrsfiedllfnkvtladagfikqygdclgdi--aar 847 (1273) +|....+++...++-+..|-+..| |+|||+.++|.+. ++++||+||||||+||..+|.|+.+.|..|.... ..| T Consensus 91 ~d~~~~~~~s~~~~~~~~~~~~~~~g~fN~s~ll~~~~~~~~~~~RS~IEDLLF~KV~t~glG~~~~Yk~Ct~~~g~~i~ 170 (472) T 6PZ8_A 91 QDDSVRNLFASVKSSQSSPIIPGFGGDFNLTLLEPVSISTGSRSARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASAR 170 (472) T ss_dssp HHHHHHHHHHHHCCSEECCCCTTTTTTSCCTTSCCC--------CCCHHHHHHHHHSCCCCCCSSSCGGGGSSSSCTTCC T ss_pred ccHHHHHHHHhccccccCCCcCCCCCCcccceeccCcCCCCCCcceeHHHHHHcCceeecCCcchHhHHHHHhcCCccHH Confidence 999999999999999988887777 5799999999775 4458999999999999999999999999999544 899 Q sp|P0DTC2|SPIK 848 DLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQF 927 (1273) Q Consensus 848 dlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqf 927 (1273) ||+|||.|||+.||||.+++||++.||++|.+|....|||+|..+|..||||+||.||+||+|+||+||.||||+|||.| T Consensus 171 DL~CaQyyNGi~VLPpv~d~~~~a~YTasL~g~ma~gg~T~GitsaaaIPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sF 250 (472) T 6PZ8_A 171 DLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKF 250 (472) T ss_dssp CTTTTHHHHTEEECCCSSHHHHHHHHHHHHHTTCSCSCSSCCSSCBCCCCHHHHHHHHHHTTTCCHHHHHHHHHHHHHHH T ss_pred HHhcccccCcEEEeCCCCCHHhHHHHHHHHHHHHHhcchhccchhhccCchHHHHHHHhhhhcccHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 928 NSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTY 1007 (1273) Q Consensus 928 nsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqty 1007 (1273) |.|||.||+.++++++||.|+|||||++++||++|++||+.|||||||.++||++|||++||++|+||||+|||.+|.+| T Consensus 251 N~Aig~iq~gf~tt~~AL~KiQ~VVN~q~~aL~~L~~qL~nnFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnaf 330 (472) T 6PZ8_A 251 NQALGAMQTGFTTTNEAFHKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQDAQIDRLINGRLTTLNAF 330 (472) T ss_dssp HHHHHTHHHHSSTTCHHHHHHHHHHHHHHHHHHHHHHGGGCCSSSSCSCHHHHHHHSCHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHchHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1008 VTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHD--- 1084 (1273) Q Consensus 1008 vtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichd--- 1084 (1273) |+|+|.|++|+|+++.||..|+.|||..||+|.+|||.|.|++|+||.||+|++|+|.+|+|.+..+.++.|.+|++ T Consensus 331 Vsq~l~~~~~v~~sr~LA~qKiNECVKSQS~R~gFCGnGtHi~Si~q~APnGi~F~H~~y~Pt~~~~V~a~~GlC~~~~~ 410 (472) T 6PZ8_A 331 VAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANP 410 (472) T ss_dssp HHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCCSSSSSSSSCEEEEEEEETTEEEEEEEEEEEECCEEEEEESCEEETTEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCCCCeeEEEEeeccCCeEEEEEEEEccCceeEEEEEeEEeecCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999995 Q sp|P0DTC2|SPIK 1085 GKAHFPREGVFVSNG-----THWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDP 1140 (1273) Q Consensus 1085 gkahfpregvfvsng-----thwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp 1140 (1273) +++..|+.|+|+.+. ++|++|.|++|+|..||.+|+.. -.|||....+|+++++| T Consensus 411 ~~~~~p~~g~fv~~n~t~~~~~w~~T~r~~Y~P~~iT~~n~v~-~sc~vny~nv~~~~~~p 470 (472) T 6PZ8_A 411 TNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSLNTKY-VAPQVTYQNISTNLPPP 470 (472) T ss_dssp EEEEEESSEEEEECCCTTCCSSEEEEESSSCCCEECCGGGEEE-CCCCTTSEEESSCCCTT T ss_pred CceEeecCceEEEeCCccccceEEEeccccccCcCCCccceEE-ecCcceEEEccccCCCC Confidence 578999999999866 46999999999999999999888 78899999999999998 No 22 >6PZ8_F S protein, G2 heavy chain; MERS-CoV, coronavirus, DPP4, receptor-binding, membrane; HET: BMA, MAN, NAG; 4.19A {Middle East respiratory syndrome-related coronavirus} Probab=100.00 E-value=3.1e-74 Score=636.33 Aligned_cols=621 Identities=20% Similarity=0.314 Sum_probs=345.6 Template_Neff=4.300 Q sp|P0DTC2|SPIK 14 QCVNL-TTRTQLPPAYT----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRF 79 (1273) Q Consensus 14 qcvnl-ttrtqlppayt----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krf 79 (1273) .|... -...-+++.++ -+-.+|+||||..++++..+-.|+||.+.-++.+-.- ++|++. + -.+ T Consensus 12 ~C~~~~~~~~~~~~~~s~~idvs~~~G~yYp~~rvysN~tll~~glfp~~gs~~~~y~---~~~~~~~~~~~~~~~~~~y 88 (726) T 6PZ8_F 12 ACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANY 88 (726) T ss_dssp BCCCEEECGGGGCCCCCCCCCGGGTTTCBCCSSCEECSEEEEEEEEECCTTCCCEEEC---CEECCBCSSSBCSEEECSC T ss_pred ceEEecccccccCCCCCcceecccCceeEeeCCeeEeeeeeeecccccCCCCcceEEE---EeecCCCCCCCccceeecC Confidence 36655 23334445555 3446899999999999999999999999988876532 333332 2 356 Q sp|P0DTC2|SPIK 80 DNPVLPFNDGVYFASTEKSNIIR-----------------GWIFGTTLDSKT---Q------SLLIVNNATNVVI----- 128 (1273) Q Consensus 80 dnpvlpfndgvyfasteksniir-----------------gwifgttldskt---q------sllivnnatnvvi----- 128 (1273) +.+..||+||+++...+..|.-. .++||+|.+... + +++|+++-.+.++ T Consensus 89 ~~~~~~F~dGifvkv~~~~n~t~~~~~~~~~~~~~~~~ypa~~fGstf~n~s~~~~~~~~~~tlvI~P~~~g~~~~~~~c 168 (726) T 6PZ8_F 89 SQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYC 168 (726) T ss_dssp TTCCEECTTCEEEEECTTTTCEEECSSSTTCEEEEECCCCCEEEESCEECCTTSCSCEECSEEEEEEEETTTTEEEEEEE T ss_pred CCChHHccCeEEEEEeeeeccCCCeeeCCCcccchhhcccceEEeccccCCCCccceeeeceEEEEecCCCCccceeeee Confidence 77889999999998887666532 256999998766 6 8999999887654 Q sp|P0DTC2|SPIK 129 --KVCEFQFCNDPFLGVYYHKNN---KSWME---------SEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVF 194 (1273) Q Consensus 129 --kvcefqfcndpflgvyyhknn---kswme---------sefrvyssannctfeyvsqpflmdlegkqgnfknlrefvf 194 (1273) ...+..-|..|..-+++.-+. .+|-. -+++.|....||+|.|. +.|-+|... ..|- |.| T Consensus 169 ~~~prt~t~C~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~-~nft~d~~~--~wf~----~~F 241 (726) T 6PZ8_F 169 ILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYT-YNITEDEIL--EWFG----ITQ 241 (726) T ss_dssp EEEECCSBTSTTSTTCCCCCEEECHHHHEETTEECTTHHHHHHHHHEEEEEEEEEEE-EECCCCCCC--EEEE----EEE T ss_pred ecccCccccCCCCCeEeeecccCCCCccCCCCcccccccccchhhheecCCcEEEEe-eecCcchhh--heEE----EEE Confidence 323344555666655542221 23422 36788899999999875 344333211 1111 999 Q sp|P0DTC2|SPIK 195 KNID-GYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 195 knid-gyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) +..| |.|-+|..++..+. ..-+| |...+.+.. .+-|+..++ .+.+. .-++|||++| T Consensus 242 ~~~~~G~f~~Y~~d~~~~~~f~f~~~~-~~~~~~yy~---------------vip~~~~~~---~~~~~-~~~~~yV~~L 301 (726) T 6PZ8_F 242 TAQGVHLFSSRYVDLYGGNMFQFATLP-VYDTIKYYS---------------IIPHSIRSI---QSDRK-AWAAFYVYKL 301 (726) T ss_dssp ETTEEEEEESTTTCTTTCCBEEEEEEC-CCSCCCEEE---------------ECCEEECCC---GGGCC-EECCEEEEEC T ss_pred eeCCceeEEEEEEecCCCcceeccccc-ceeccceee---------------eeeeeecCC---cccce-eEEEEEEEEc Confidence 9999 99999877655442 22233 444444443 333444444 45566 7889999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASV 350 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasv 350 (1273) .+|+|||+|+.||.|++||||+-|+++|-||..+||.+++|+|++|+||+||....+|.++. ..|+|.++++ .++.++ T Consensus 302 ~~~~yLl~Fd~nG~It~AvDCa~d~~sEL~Cst~Sf~p~tGVY~lS~y~aqP~g~V~~~~~~-~~C~~~~~~~-~~~Psp 379 (726) T 6PZ8_F 302 QPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEG-VECDFSPLLS-GTPPQV 379 (726) T ss_dssp EEEEEEEEECTTSCEEEEEETTSSHHHHHHHHTSSSSSSCSCEEEEEECCCCEEEEEECCC------------------- T ss_pred ccceEEEecCCCCeEEEEEeccCCccccceeEeeeecCCCCeeecCcEEEEeeeEEEEecCC-CCCCChHHhc-CCCCCc Confidence 99999999999999999999999999999999999999999999999999999999999999 9999999999 889999 Q sp|P0DTC2|SPIK 351 YAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT 430 (1273) Q Consensus 351 yawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddft 430 (1273) +.|.|+.++||..|+++|++....+.|+||||+|.||.+.||..|++|.|.|..+..++++||++|-|++||||+|++|+ T Consensus 380 ~~w~R~~fsNCnfN~s~Lls~~~~~~f~C~gIspskLa~mCfsSvtiD~Faip~s~~~~L~~g~~g~i~~yNYkld~~~~ 459 (726) T 6PZ8_F 380 YNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNP 459 (726) T ss_dssp -------------------------------------------------------------------------------- T ss_pred ceeeEEEEecccccHHHHHhccceeeeeecCCCHHHHhhhccceeeEEEEEcchhhccccCCCCCccchhccccCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 431 GCVIAWNSNNLDSK--VGGNYNYLYRLFRKSNLKPFERDISTEIYQAG--STPCN--GVEGFNCYFPLQS---------- 494 (1273) Q Consensus 431 gcviawnsnnldsk--vggnynylyrlfrksnlkpferdisteiyqag--stpcn--gvegfncyfplqs---------- 494 (1273) ||+++|+-.+++.. --.+|+|+-|-.+... ++. +++-|-- .+-|+ ... -+|+.+... T Consensus 460 ~C~l~~~~~~~~~n~t~~~~~~~i~~~~~~~~-----~~~-~~~~~~~~~~~~cpc~~~~-~~~~~~~~~~~~~~~~~~~ 532 (726) T 6PZ8_F 460 TCLILATVPHNLTTITKPLKYSYINKCSRLLS-----DDR-TEVPQLVNANQYSPCVSIV-PSTVWEDGDYYRKQLSPLE 532 (726) T ss_dssp -------------------------------------------------------------------------------- T ss_pred ceEEEEEcCcccccCCCcccceeeeeeccCCC-----CCC-cchhhhccccccCCCcccC-CccccCCCCcccccccccc Confidence 99999985442222 2567777776666443 222 2221100 11111 000 112221111 Q sp|P0DTC2|SPIK 495 -YGFQP----TNGVGYQPYRVVVLSFELLHAPATVCGPK-----KSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQ 564 (1273) Q Consensus 495 -ygfqp----tngvgyqpyrvvvlsfellhapatvcgpk-----kstnlvknkcvnfnfngltgtgvltesnkkflpfqq 564 (1273) -+..+ ..++++|.+.+++++++..-.+.|||..+ ..++++.++||++|..|.+|+||++++|..+...+. T Consensus 533 ~~~~~~~~~~~~~~~~~c~~lvvIt~~~gs~~~TvcP~~~~~~~~~s~i~l~~Cv~YnIYG~tG~GvI~~~n~~~~~gl~ 612 (726) T 6PZ8_F 533 GGGWLVASGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQR 612 (726) T ss_dssp -------------------------------------------CCSCSCCCSSSEEEEETTEEEEECEEECCCCSCTTSC T ss_pred CCccccccccceecccceeEEEEEEeecCCCccccccccccccCCceeeeeCeeeeEEeCCceeeEEEEecCeeeeCCEE Confidence 12222 34889999999999999999999999442 247999999999999999999999999999999999 Q sp|P0DTC2|SPIK 565 FGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRV--YSTGSNV 642 (1273) Q Consensus 565 fgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrv--ystgsnv 642 (1273) +..+.+.-.-++++ .++++..|+||..+.++++..|+ ++.++.||..++|+.+....+..+.+|.||+ +++..+. T Consensus 613 ~~~s~sg~l~~fk~-~~g~~Y~V~PC~~v~~qvvv~~~--s~~~vgl~ts~nc~~v~~~~~~~~~s~~~~~~~~~~~~~~ 689 (726) T 6PZ8_F 613 FVYDAYQNLVGYYS-DDGNYYCLRACVSVPVSVIYDKE--TKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGP 689 (726) T ss_dssp EEECTTSCEEEEEC-TTSCEEEECCCCCEEEEEEEETT--TTEEEEECGGGCGGGCCSSCSSCSSSCCHHHHHHHTTSCC T ss_pred EEecCCCCEEEEEe-CCCCEEEEecCcccceeEEEeCC--CCCEEEEEecccCccccccceeeccCCchhcccccCCCCC Confidence 97788888999999 99999999999999999999997 7889999999999999999999999999998 8888899 Q sp|P0DTC2|SPIK 643 FQTRAGCLIGAEHVNN-SYECDIPIGAGICASYQT 676 (1273) Q Consensus 643 fqtragcligaehvnn-syecdipigagicasyqt 676 (1273) |||-+||++||++.+. ..|||+|+|+|+||.|.+ T Consensus 690 fdT~~GCV~na~n~t~~V~~C~LplG~slC~~~~~ 724 (726) T 6PZ8_F 690 LQTPVGCVLGLVNSSLFVEDCKLPLGQSLCALPDT 724 (726) T ss_dssp EECSSCEEETCCEEEEEESCCSSEEETTEEEECCC T ss_pred CCCchheeeeeecCCCceeeCCCCCCcceecCCCC Confidence 9999999999999998 999999999999999976 No 23 >7BZ5_A Spike protein S1, Heavy chain; covid-19 antibody, VIRAL PROTEIN, VIRAL; HET: NAG; 1.84A {Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=3.5e-52 Score=416.50 Aligned_cols=225 Identities=99% Similarity=1.598 Sum_probs=190.3 Template_Neff=4.100 Q sp|P0DTC2|SPIK 319 RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD 398 (1273) Q Consensus 319 rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyad 398 (1273) |+||...++|++++++.|+|.++|+|.++.++|+|.|+.++||..|+++|++..++++|+||||||+||.++||.+|++| T Consensus 1 raqP~g~V~r~~~~~~~C~~~~~l~~~~~Psp~nW~R~~fsNCnfn~s~Lls~~~~~sf~C~gIspskL~~mCfsSvtiD 80 (229) T 7BZ5_A 1 RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD 80 (229) T ss_dssp ---------------CBCCHHHHHTCSSCCBGGGCEEEEECSEECCCHHHHSCSCCSEEEEESSCSTTCTTCEESEEEEE T ss_pred CcccceEEEECCCCCCCCChHHHhcCCCCCCchheEEeEEecCCCcHHHHhhcceeceeeEeCCCHHHHcccccCeeEEE Confidence 78999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 399 SFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGST 478 (1273) Q Consensus 399 sfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagst 478 (1273) .|.|+++++++++||++|.|++||||||+||+||+|+|+..+++..+.++|||++|.+++++++|||||++.++|+++.+ T Consensus 81 ~Faip~s~~~~L~~G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~~~vt~~~~y~~rr~~~~~~~~f~~~~~~~~y~~~~~ 160 (229) T 7BZ5_A 81 SFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGST 160 (229) T ss_dssp EEEEEGGGGGGSSTTCCSHHHHHTCCCCTTCCEEEEEEECHHHHCCTTCBCCCEEECCCSSCCCTTCCCCCCCCEECSSS T ss_pred EEEecccceeecCCCCCcHHHhcccCCCCCCCCeEEEEEeCCcccccccchHHHHHhccccCCCccccCCccceeccCCC Confidence 99999999999999999999999999999999999999999999888899999999999999999999999999999999 Q sp|P0DTC2|SPIK 479 PCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNF 543 (1273) Q Consensus 479 pcngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnf 543 (1273) .|++..+.+|+.|+..|++|++.|+|+|+|+|+|++++...+++|||++|.+|++++++||||.. T Consensus 161 ~c~~~~~~~c~~p~~~~~~~~~~g~g~~c~g~~Vis~k~~~~s~TVC~~~~~T~~v~g~~~~~~~ 225 (229) T 7BZ5_A 161 PCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFHH 225 (229) T ss_dssp CCTTCCBTTEECSEEECCBCTTBCGGGSEEEEEEEEEECC-CCCCEECCC--------------- T ss_pred CCCCCCcccceeccCCCCCcccccccccceEEEEEEEEccCCCCccCCCCCCHHHhcCeeecCCC Confidence 99955599999999999988899999999999999999999999999999999999999999964 No 24 >6YZ5_E Spike glycoprotein, Nanobody H11-D4; nanobody, complex, SARS-Cov-2, VIRAL PROTEIN; HET: NAG, EDO, ACT; 1.8A {Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=3.5e-51 Score=405.64 Aligned_cols=205 Identities=99% Similarity=1.601 Sum_probs=193.3 Template_Neff=3.900 Q sp|P0DTC2|SPIK 330 PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQ 409 (1273) Q Consensus 330 pnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrq 409 (1273) ||+++.|+|.++|+|.++.|+|+|.|+.++||+.|+|+|+++.++++|+||||||+||.++||.+|++|.|.|+++++++ T Consensus 1 ~~~~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfNlS~Lls~~~~~sF~C~gIspskLa~mCfsSVtiD~Faip~s~~~d 80 (210) T 6YZ5_E 1 PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQ 80 (210) T ss_dssp ----CBCCHHHHHTCSSCCBGGGCEEEEECSEECCTHHHHTCSSCSEEEEESCCHHHHTTCEESEEEEEEEEEEGGGGGG T ss_pred CCCcCCCCHHHHhcCCCCCCchheEEeEEecCCCcHHHHhhcceeceeeeeCCCHHHHcccccCeeEEEEEEecccceee Confidence 78899999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 410 IAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY 489 (1273) Q Consensus 410 iapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncy 489 (1273) ++||++|.|++||||||+||+||+|+|+..+++..+.++|||++|.+++++++||||+++.++|+++.+.|++..+.||+ T Consensus 81 Lq~G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~vnvts~yny~~rr~~~~~~~~f~~~~~~~~y~~~~~~c~~~~~~~c~ 160 (210) T 6YZ5_E 81 IAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY 160 (210) T ss_dssp SSTTCCSHHHHHTCCCCTTCCEEEEEEECHHHHCCTTCBCCCEEECCCSSCCCTTCCCCCCCCEECSSSCCTTCCBTTEE T ss_pred cCCCCCcHHHhcccCCCCCCCCeEEEEEeCCccccccccHHHHHHhcccCCCCccccccccchhccCCCCCCCCccccce Confidence 99999999999999999999999999999999999999999999999999999999999999999999999955599999 Q sp|P0DTC2|SPIK 490 FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLV 534 (1273) Q Consensus 490 fplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlv 534 (1273) .|+..|++|.+.|+|+|+|+|+|++++.+++|+||||||+|||.- T Consensus 161 ~p~~~~~~~~~~g~g~~c~gv~Vis~k~~~~~~t~~~~~~~~~~~ 205 (210) T 6YZ5_E 161 FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNKH 205 (210) T ss_dssp CSEEECCBCTTSCGGGSEEEEEEEEEECCSSCCCEECCCCT---- T ss_pred ecccCCCCCCcccCCccceEEEEEEEEcCCCceEEeCcccccCCC Confidence 999998988899999999999999999999999999999999853 No 25 >6YLA_E SARS-CoV-2 RBD, Heavy Chain, Light; SARS-CoV-2 Spike protein, RBD, CR3022; HET: DMS, MLI, 1PE, NAG; 2.42A {Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=3.8e-51 Score=406.04 Aligned_cols=207 Identities=98% Similarity=1.577 Sum_probs=201.0 Template_Neff=3.900 Q sp|P0DTC2|SPIK 328 RFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEV 407 (1273) Q Consensus 328 rfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdev 407 (1273) .||++++.|+|.++|||.++.|+|+|.|+.++||+.|+|+|+++.++++|+||||||+||.++||.+|++|.|.|+++++ T Consensus 2 ~~~~~~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfNlS~Lls~~~~~sF~C~gIspskLa~mCfsSVtiD~Faip~s~~ 81 (213) T 6YLA_E 2 TGPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEV 81 (213) T ss_pred CCCCCcCCCCHHHHhcCCCCCCchheEEeEEecCCCcHHHHhhcceeceeeeeCCCHHHHcccccCeeEEEEEEecccce Confidence 47999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 408 RQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFN 487 (1273) Q Consensus 408 rqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfn 487 (1273) ++++||++|.|++||||||+||+||+|+|+..+++..+.++|||++|.+++++++||||+++.++|+++.+.|++..+.| T Consensus 82 ~dLq~G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~vnvts~yny~~rr~~~~~~~~f~~~~~~~~y~~~~~~c~~~~~~~ 161 (213) T 6YLA_E 82 RQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFN 161 (213) T ss_pred eecCCCCCcHHHhcccCCCCCCCCeEEEEEeCCccccccccHHHHHHhcccCCCCccccccccchhccCCCCCCCCcccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999555999 Q sp|P0DTC2|SPIK 488 CYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLV 534 (1273) Q Consensus 488 cyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlv 534 (1273) ||.|+..|++|.+.|+|+|+|+|+|++++.+++|+||||||+|||.- T Consensus 162 c~~p~~~~~~~~~~g~g~~c~gv~Vis~k~~~~~~t~~~~~~~~~~~ 208 (213) T 6YLA_E 162 CYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNKH 208 (213) T ss_pred ceecccCCCCCCcccCCccceEEEEEEEEcCCCceEEeCcccccCCC Confidence 99999998988899999999999999999999999999999999853 No 26 >6ZFO_A SARS-CoV-2 RBD, Nanobody, EY6A heavy; EY6a, RBD, Spike glycoprotein, SARS-CoV-2; HET: NAG;{Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=2.3e-47 Score=375.21 Aligned_cols=194 Identities=100% Similarity=1.634 Sum_probs=189.3 Template_Neff=4.100 Q sp|P0DTC2|SPIK 333 TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP 412 (1273) Q Consensus 333 tnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiap 412 (1273) |+.|+|.++|||.++.++|+|.||.++||+.|+|+|+++.++++|+||||+|+||.++||.+|++|.|.|+++++++++| T Consensus 1 ~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfn~S~Lls~~~~~sf~C~gIspskL~~mCfsSvtiD~Faip~s~~~~L~~ 80 (194) T 6ZFO_A 1 TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP 80 (194) T ss_dssp CCBCCCHHHHSCSSCCCSTTCEEEEECSEECCTHHHHHCCCCSEEEEESSCSGGGTTCCBSEEEEEEEEEEHHHHTTSST T ss_pred CCCCCHHHhhccCCCCCchheEEeEEecCCCcHHHHhhcceeceeeeeCCCHHHHcccccCeeEEEEEEecccceeecCC Confidence 57899999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 413 GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL 492 (1273) Q Consensus 413 gqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfpl 492 (1273) |++|.|++||||||+||+||+|+|+..+++..+.++|||++|.+++++++||||+++.++|+++.+.|++..+.||+.|+ T Consensus 81 G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~~nvt~~y~y~~~~~~~~~~~~f~~~~~~~~y~~~~~~c~~~~~~~c~~p~ 160 (194) T 6ZFO_A 81 GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL 160 (194) T ss_dssp TCCSHHHHHTCCCCTTCCEEEEEEECTTTSCCTTCBCCCEEECCCSSCCCTTCCCCCCCCEECSSSCCSSCCBTTEECSE T ss_pred CCCcHHHhcccCCCCCCCCeEEEEEeCCccccccccHHHHHHhcccCCCCccccccccchhccCCCCCCCCccccceecc Confidence 99999999999999999999999999999999999999999999999999999999999999999999955599999999 Q sp|P0DTC2|SPIK 493 QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG 526 (1273) Q Consensus 493 qsygfqptngvgyqpyrvvvlsfellhapatvcg 526 (1273) ..|++|++.|+|+|+|+|+|++++.+|+|+|||| T Consensus 161 ~~~~~~~~~g~g~~c~g~~Vis~k~~~~~~t~~~ 194 (194) T 6ZFO_A 161 QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG 194 (194) T ss_dssp EECCBCTTSCTTTSEEEEEEEEEECCSSCCCEEC T ss_pred cCCCCCCcccCCccceEEEEEEEEcCCCcceecC Confidence 9989888999999999999999999999999998 No 27 >2GHV_C Spike glycoprotein; SARS, S protein, VIRAL PROTEIN; 2.2A {SARS coronavirus} SCOP: d.318.1.1 Probab=100.00 E-value=3.9e-37 Score=305.00 Aligned_cols=197 Identities=71% Similarity=1.226 Sum_probs=171.8 Template_Neff=4.000 Q sp|P0DTC2|SPIK 330 PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQ 409 (1273) Q Consensus 330 pnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrq 409 (1273) |+++..|+|.++|+|.++.++|+|.|+.++||..|+|+|++..++++|+||||||+||.++||..|++|.|.|..+++++ T Consensus 4 ~~~~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfnls~Lls~~~~~sf~C~gIspskLa~mCfsSvtiD~Faip~s~~~~ 83 (203) T 2GHV_C 4 PNITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQ 83 (203) T ss_dssp ---CCBCCCHHHHSCSSCCBGGGCEEEEECSSBCCGGGSCSCCBCSEEEEESCBGGGGGGGGCSSEEEEEEEEEGGGGGG T ss_pred CCccCCCCHHHHhcCCCCCCcceeEEeEEecCCCCHHHHhhccccceeeeeCCCHHHHcccccCeeEEEEEEeccchhhh Confidence 67789999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 410 IAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY 489 (1273) Q Consensus 410 iapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncy 489 (1273) ++||++|-|++||||||+||+||+++|+-.+++..+.+|||+.++-.|...++|+++|++.-.+-.+..||....-.+|+ T Consensus 84 Lq~G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~vn~t~~~nps~~~~r~~~~~~~~~~~c~c~~~~~~~~c~~~~~~~p~ 163 (203) T 2GHV_C 84 IAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYW 163 (203) T ss_dssp SSTTCCSHHHHHTCCCCTTCCEEEEEEECHHHHCBTTCBCCCEEECCCSSCCCTTCCCCCCCCBCTTSCCCCTTSTTCBC T ss_pred cCCCCCcHHHhcccCCCCCCcceEEEEEeCccccccCCccCcccchhcccccccCCCccCCCCCCCCCCCCCCCCccccc Confidence 99999999999999999999999999999888888888788777665555689999999986664444566543333334 Q sp|P0DTC2|SPIK 490 FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP 527 (1273) Q Consensus 490 fplqsygfqptngvgyqpyrvvvlsfellhapatvcgp 527 (1273) .|-. +++..+.|+|+|+|+|+|++++.+.+|+||||- T Consensus 164 ~~~~-~~~~~~~g~g~~c~g~~Vis~k~~~~~~t~~~~ 200 (203) T 2GHV_C 164 PLND-YGFYTTTGIGYQPYRVVVLSFELLNAPATVSGL 200 (203) T ss_dssp CEEE-CCBBSSSCGGGSEEEEEEEEECSGGSTCBTTCC T ss_pred CCCc-CCceecccCCccceEEEEEEEEcCCCceEEeee Confidence 4322 556677899999999999999999999999994 No 28 >1WYY_A E2 Glycoprotein; membrane fusion, severe acute respiratory; 2.2A {SARS coronavirus} SCOP: h.3.3.1 Probab=100.00 E-value=2.3e-36 Score=288.46 Aligned_cols=99 Identities=89% Similarity=1.142 Sum_probs=83.9 Template_Neff=2.300 Q sp|P0DTC2|SPIK 903 AYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS 982 (1273) Q Consensus 903 ayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndils 982 (1273) +||+|++|++++||.||||+||+.||.|++.|+..++++++||.|+|||||++++||+.|+.||+.|||||||.++||.+ T Consensus 3 ~~RlNyvalqt~VLq~NQk~iA~sFN~Ai~~i~~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~nNFgAISSSI~dIy~ 82 (149) T 1WYY_A 3 AYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS 82 (149) T ss_dssp -----CCSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ccccchhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHH Confidence 69999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 983 RLDKVEAEVQIDRLITGRL 1001 (1273) Q Consensus 983 rldkveaevqidrlitgrl 1001 (1273) |||++||.+|+|||||||+ T Consensus 83 RLD~leAdaQVDRLItGR~ 101 (149) T 1WYY_A 83 RLDKVEAEVQIDRLITGGR 101 (149) T ss_dssp HHHHHHHHC---------- T ss_pred HHHHHHHHHHHHHHHhcCC Confidence 9999999999999999985 No 29 >1WYY_B E2 Glycoprotein; membrane fusion, severe acute respiratory; 2.2A {SARS coronavirus} SCOP: h.3.3.1 Probab=100.00 E-value=2.3e-36 Score=288.46 Aligned_cols=99 Identities=89% Similarity=1.142 Sum_probs=81.9 Template_Neff=2.300 Q sp|P0DTC2|SPIK 903 AYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS 982 (1273) Q Consensus 903 ayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndils 982 (1273) +||+|++|++++||.||||+||+.||.|++.|+..++++++||.|+|||||++++||+.|+.||+.|||||||.++||.+ T Consensus 3 ~~RlNyvalqt~VLq~NQk~iA~sFN~Ai~~i~~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~nNFgAISSSI~dIy~ 82 (149) T 1WYY_B 3 AYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS 82 (149) T ss_dssp -------CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ccccchhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHH Confidence 69999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 983 RLDKVEAEVQIDRLITGRL 1001 (1273) Q Consensus 983 rldkveaevqidrlitgrl 1001 (1273) |||++||.+|+|||||||+ T Consensus 83 RLD~leAdaQVDRLItGR~ 101 (149) T 1WYY_B 83 RLDKVEAEVQIDRLITGGR 101 (149) T ss_dssp HHHHHHHHC---------- T ss_pred HHHHHHHHHHHHHHHhcCC Confidence 9999999999999999985 No 30 >5X4S_A Spike glycoprotein; SARS-CoV, spike, N-terminal domain, VIRAL; HET: NAG; 2.2A {Human SARS coronavirus} Probab=100.00 E-value=1.1e-34 Score=297.96 Aligned_cols=261 Identities=56% Similarity=1.068 Sum_probs=238.0 Template_Neff=4.200 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTT 109 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgtt 109 (1273) -|-.+|+||||..+||+..+-.|+||.++-++++-+|. .--.+++++.||+||+++...+++|.-++|+||+| T Consensus 21 ~s~~~G~yYPd~~~ysN~t~L~qglfp~~gs~~~~~~~-------~~~~y~~~~~~F~dGifv~v~~~~n~t~a~~fGst 93 (285) T 5X4S_A 21 TSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHT-------INHTFDNPVIPFKDGIYFAATEKSNVVRGWVFGST 93 (285) T ss_pred cccCceeEecCCeeeecceeeeecccCCCCCCccccCC-------cceecCCCccccCCeEEEEeeeecCCCCceeeeec Confidence 34568999999999999999999999999999998555 23568899999999999999999999889999999 Q sp|P0DTC2|SPIK 110 LDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNL 189 (1273) Q Consensus 110 ldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknl 189 (1273) .+.++++++|+++-+...|.+|.|+.|..|.+.++..-.| --++..|..+.||+|+|.|+.|-+|...+-.+.... T Consensus 94 f~N~s~tviI~p~~~~~~it~C~~~vC~~p~~~~~~~~g~----~~~~~~f~~~~nc~~~~~~~nfT~d~~~~~~~~~~r 169 (285) T 5X4S_A 94 MNNKSQSVIIINNSTNVVIRACNFELCDNPFFAVSKPMGT----QTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHL 169 (285) T ss_pred ccCCcEEEEEcCCCCcceEEEeEEEeCCCCeeEEcCCCCc----ccccceeeecCCCeEEEcccccccccCcceeeeeeE Confidence 9999999999999999999999999999999998874333 567888999999999999999999988888888889 Q sp|P0DTC2|SPIK 190 REFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGY 269 (1273) Q Consensus 190 refvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgy 269 (1273) ++|+|++.||+|-+|....+.+..+.+|.|+..|.|..-+|..|+||.|...+ |.|-++ .+.|..+.++|||++ T Consensus 170 ~~f~F~~~dG~f~~Y~~~~~~~~f~~~p~~~~~l~yy~vip~s~~~~~~~~~~---~~~~~~---~~~~~~~~~a~yV~~ 243 (285) T 5X4S_A 170 REFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNTLKPIFKLPLGINITNFRAIL---TAFSPA---QDTWGTSAAAYFVGY 243 (285) T ss_pred EEEEEEeeCCeEEEEEecCCCcccccCCCccccceeeEeeeeecccccccCCC---CCCCCC---CcccceeeEEEEEEe Confidence 99999999999999999888887999999999999999999999999997766 777776 678889999999999 Q sp|P0DTC2|SPIK 270 LQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFT 307 (1273) Q Consensus 270 lqprtfllkynengtitdavdcaldplsetkctlksft 307 (1273) |.||+|||+|++||+|++||||+-||++|-||..||-. T Consensus 244 L~~~t~Ll~fd~nG~It~AvDCa~~~~sELkCs~~~~~ 281 (285) T 5X4S_A 244 LKPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSHH 281 (285) T ss_pred cceeeEEEeecCCCeEeeEEEcccCcchhceeeecCCC Confidence 99999999999999999999999999999999998753 No 31 >5KWB_A Spike glycoprotein; Coronavirus spike protein, S1-CTD, receptor; HET: NAG, SUC; 1.91A {Human coronavirus HKU1 (isolate N1)} Probab=99.95 E-value=1.2e-33 Score=297.87 Aligned_cols=271 Identities=23% Similarity=0.387 Sum_probs=226.6 Template_Neff=3.700 Q sp|P0DTC2|SPIK 316 SNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNV 395 (1273) Q Consensus 316 snfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnv 395 (1273) |+|||||...++|.+.....|+|.++++|.+..+++.|.||.++||..|+|+|++......|+|||++|.||.+.||..| T Consensus 1 S~y~vqP~g~V~r~~~~~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfNls~Lls~v~~~sf~C~~i~pskl~~mCfsSv 80 (371) T 5KWB_A 1 SGFTVKPVATVHRRIPDLPDCDIDKWLNNFNVPSPLNWERKIFSNCNFNLSTLLRLVHTDSFSCNNFDESKIYGSCFKSI 80 (371) T ss_dssp ----CCCCCSEEECCTTCCBCCHHHHHTCSEEECGGGCEEEEECSEEECHHHHHHHTEEEEEEEESSCGGGTTTCEESEE T ss_pred CCceeeeeeEEEEeCCCCCCCCHHHHHhCCCCCCccccEEeEEecCCCCHHHHHhhceeceeeeeCCCHHHhcccccCee Confidence 68999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 396 YADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGG----NYNYLYRLFRKSNLKPFERDISTE 471 (1273) Q Consensus 396 yadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvgg----nynylyrlfrksnlkpferdiste 471 (1273) +.|.|.|..+..+++++|.+|-|++||||+|++|++|+++|+-..++..+.+ +|| |.++..+ |+...... T Consensus 81 tiD~Faip~s~~~dLq~g~sG~i~~~NYKid~~~~sC~l~y~~~~~nvt~t~~nps~~n---~ry~~~~---f~~~~hdv 154 (371) T 5KWB_A 81 VLDKFAIPNSRRSDLQLGSSGFLQSSNYKIDTTSSSCQLYYSLPAINVTINNYNPSSWN---RRYGFNN---FNLSSHSV 154 (371) T ss_dssp EEEEEECCGGGGGGGSTTCCSHHHHHTCCCCSSSCEEEEEEEEEGGGCEEECCCCCHHH---HHTTCCC---CCCCTTEE T ss_pred EEEEEecCcccchhccCCCCcHhHhccccCCCCCCceEEEEEcccceeeecCCCcccch---hhccccC---cCccccce Confidence 9999999999999999999999999999999999999999997665555443 454 2223222 55555555 Q sp|P0DTC2|SPIK 472 IYQ-----AGSTPCN---------------------------------------------GVEGFNCYFPLQSYGFQPTN 501 (1273) Q Consensus 472 iyq-----agstpcn---------------------------------------------gvegfncyfplqsygfqptn 501 (1273) +|. ++.+-|. +..++.|+-+...+.....- T Consensus 155 vYs~~cf~~~~~yCPC~~p~~~~~c~~~~~~~~~~~~~t~~r~c~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~q~~~~~ 234 (371) T 5KWB_A 155 VYSRYCFSVNNTFCPCAKPSFASSCKSHKPPSASCPIGTNYRSCESTTVLDHTDWCRCSCLPDPITAYDPRSCSQKKSLV 234 (371) T ss_dssp EEESCCEECCTTCCCSBCHHHHTTCCBSCCCBCBCCTTCCCCCEEEEEETTEEEEEEESSCSCTTTCSCGGGCSSEECCC T ss_pred eeeeeeeecCCCccCCCCccccccccCCCCCCCCCCCCccccccccccccccccccccccCCCCCcccCCCCccCceeee Confidence 554 2222221 11234455454444445567 Q sp|P0DTC2|SPIK 502 GVGYQPYRVVVLSFEL-----------------------------------------LHAPATVCGP---KKSTNLVKNK 537 (1273) Q Consensus 502 gvgyqpyrvvvlsfel-----------------------------------------lhapatvcgp---kkstnlvknk 537 (1273) |+|++.+.+.|++.+. .-.++|+|.. +..++++.++ T Consensus 235 gvg~~c~gl~v~~~kcg~~~~~~~~~C~C~~~af~gws~dsc~~~~~c~~f~n~~~~~~~T~t~cP~~~~~~~s~I~l~~ 314 (371) T 5KWB_A 235 GVGEHCAGFGVDEEKCGVLDGSYNVSCLCSTDAFLGWSYDTCVSNNRCNIFSNFILNGINSGTTCSNDLLQPNTEVFTDV 314 (371) T ss_dssp CTTCCCCCCCBCGGGBSBTTCCTTSBCCBCGGGBCSEEEEECEETTEEEEEEEEEEESTTCSSEEECSSCCCCCCCCCSS T ss_pred ccccccceEEEeeeeccCCCCCCCcccccCCCccccccccccccCCceeeccceeccCCCCCCcCCCcccCCCceEEeCe Confidence 9999999999999998 5668999998 6779999999 Q sp|P0DTC2|SPIK 538 CVNFNFNGLTGTGVLTE-SNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSF 592 (1273) Q Consensus 538 cvnfnfngltgtgvlte-snkkflpfqqfgrdiadttdavrdpqtleilditpcsf 592 (1273) ||++|..|.+|+|++++ +++.++..|.+..+.+.-..+++++.++++..|+||.. T Consensus 315 CVdYnIYG~tGqGvItnvT~~~~l~~~gL~yS~sgdl~~fk~~~tg~~Y~V~PC~~ 370 (371) T 5KWB_A 315 CVDYDLYGITGQGIFKEVSAVYYNSWQNLLYDSNGNIIGFKDFVTNKTYNIFPCYA 370 (371) T ss_dssp EEEEEETTEEEEEEEEEECGGGCCCSSSEEECTTSCEEEEECTTTCCEEEEECC-- T ss_pred eeeEEeCCCeeeEEEEeccCceeecCCcEEEcCCCCEEEEEcCCCCcEEEEeeccc Confidence 99999999999999999 99889999999999999999999999999999999975 No 32 >6LXT_F Spike protein S2; 2019-nCoV, HR1 and HR2 domain; HET: PG4; 2.9A {Severe acute respiratory syndrome coronavirus 2} Probab=99.90 E-value=2.8e-28 Score=230.50 Aligned_cols=112 Identities=72% Similarity=0.855 Sum_probs=97.2 Template_Neff=2.500 Q sp|P0DTC2|SPIK 910 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEA 989 (1273) Q Consensus 910 gvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkvea 989 (1273) |+|++||.||||+||+.||.|++.|++.++++++||.|+|||||++++||+.|++||+.|||||||.++||.+|||++|| T Consensus 1 gltt~VLq~NQk~iAnsFN~AignI~~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~~NFgAISSSI~DIy~RLD~leA 80 (132) T 6LXT_F 1 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVES 80 (132) T ss_dssp ---CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC- T ss_pred CCchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHc Confidence 68999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 990 EVQID-RLITGRLQSLQTYVTQQLIRAAEIRAS 1021 (1273) Q Consensus 990 evqid-rlitgrlqslqtyvtqqliraaeiras 1021 (1273) ..|+| |||||||.+|..||+|.+.+.++...- T Consensus 81 daQvD~RLItGRLaaLna~v~q~~~~~~~~~~~ 113 (132) T 6LXT_F 81 GGRGGPDVDLGDISGINASVVNIQKEIDRLNEV 113 (132) T ss_dssp ---------CCCCTTCCCCCCCCHHHHHHHHHH T ss_pred cccCCcchhcccHHHHHHHHHHHHHHHHHHHHH Confidence 99999 799999999999999999998887543 No 33 >6LXT_C 2019-nCoV S2 subunit; 2019-nCoV, HR1 and HR2 domain; HET: PG4; 2.9A {COVID-19 virus} Probab=99.90 E-value=2.8e-28 Score=230.50 Aligned_cols=112 Identities=72% Similarity=0.855 Sum_probs=100.9 Template_Neff=2.500 Q sp|P0DTC2|SPIK 910 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEA 989 (1273) Q Consensus 910 gvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkvea 989 (1273) |+|++||.||||+||+.||.|++.|++.++++++||.|+|||||++++||+.|++||+.|||||||.++||.+|||++|| T Consensus 1 gltt~VLq~NQk~iAnsFN~AignI~~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~~NFgAISSSI~DIy~RLD~leA 80 (132) T 6LXT_C 1 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVES 80 (132) T ss_dssp --CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC- T ss_pred CCchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHc Confidence 68999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 990 EVQID-RLITGRLQSLQTYVTQQLIRAAEIRAS 1021 (1273) Q Consensus 990 evqid-rlitgrlqslqtyvtqqliraaeiras 1021 (1273) ..|+| |||||||.+|..||+|.+.+.++...- T Consensus 81 daQvD~RLItGRLaaLna~v~q~~~~~~~~~~~ 113 (132) T 6LXT_C 81 GGRGGPDVDLGDISGINASVVNIQKEIDRLNEV 113 (132) T ss_dssp ------CCCCCCCTTCCCCCCCCHHHHHHHHHH T ss_pred cccCCcchhcccHHHHHHHHHHHHHHHHHHHHH Confidence 99999 799999999999999999998887543 No 34 >6C6Z_A Spike protein, CDC2-C2 heavy chain; immune system, antibody, fusion glycoprotein; HET: NAG; 2.1A {Middle East respiratory syndrome-related coronavirus} Probab=99.85 E-value=6.9e-26 Score=228.84 Aligned_cols=148 Identities=22% Similarity=0.358 Sum_probs=108.8 Template_Neff=3.300 Q sp|P0DTC2|SPIK 319 RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD 398 (1273) Q Consensus 319 rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyad 398 (1273) |+||...++|+++. ..|+|.++++ .++.++|.|.|+.++||..|+++|++...+++|+||||+|.||.++||..|++| T Consensus 1 rAqP~g~V~r~~~~-~~C~~~~~l~-~~~Psp~nWeR~~fsNCnfNlS~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD 78 (231) T 6C6Z_A 1 EAKPSGSVVEQAEG-VECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILD 78 (231) T ss_dssp ---------------CBCCCHHHHS-BCCCBGGGCEEEEECSSBCCHHHHHTTSEEEEEEEC-----------CCEEEEE T ss_pred CccceeEEEEecCC-CCCCchHHhc-CCCCCcceeEEEEEecCCccHHHHHhcceeeeeeecCCCHHHHhhhccceeeEE Confidence 68999999999999 9999999999 999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 399 SFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEI 472 (1273) Q Consensus 399 sfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdistei 472 (1273) .|.|..++.++++||++|-|++||||+|+||+||+++|+-.+++..+.++.+|-|+..|. +|..|-++|. T Consensus 79 ~FaIp~s~~~~Lq~G~sG~i~~yNYKlp~~f~gC~l~y~~~~~~vnvt~p~~y~yia~r~----~~~~~~~~~~ 148 (231) T 6C6Z_A 79 YFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCS----RFLSDDRTEV 148 (231) T ss_dssp EEECCGGGGGGSSSSCCSHCCCCCCCCCSSSCEEEEEEECCTTCTTBCCCSEEEEEEEEE----EECTTSSCEE T ss_pred EEecChhhhhhccCCCCCchhhccccCCCCCCceEEEEEcCccccccCCCccceeeeeee----ccCCCCceEE Confidence 999999999999999999999999999999999999999777666555566666655544 3334445554 No 35 >5XGR_H Spike protein S1; MERS-CoV, BatCoV HKU5, CTD, evolution; HET: NAG; 2.1A {Bat coronavirus HKU5} Probab=99.85 E-value=9.7e-26 Score=224.72 Aligned_cols=181 Identities=21% Similarity=0.336 Sum_probs=148.3 Template_Neff=4.000 Q sp|P0DTC2|SPIK 335 LCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQ 414 (1273) Q Consensus 335 lcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgq 414 (1273) .|+|.++++ .++.++|.|.|+.++||..|+++|++..++++|+||||+|.||.+.||..|++|.|.|..+..++++||+ T Consensus 2 ~C~~~~~l~-~~~Psp~nWeR~~fsNCnfNls~Lls~v~v~sF~C~~IspskLa~mCfsSvtiD~Faip~s~~~dLq~G~ 80 (204) T 5XGR_H 2 ECDFTPMLT-GTPPPIYNFKRLVFTNCNYNLTKLLSLFQVSEFSCHQVSPSSLATGCYSSLTVDYFAYSTDMSSYLQPGS 80 (204) T ss_dssp BCCCGGGGS-BCCCCGGGCEEEEECSEEECHHHHHTTSEEEEEEEESCCHHHHSSCCBSEEEEEEEECCGGGGGGGSTTC T ss_pred CCCChhHhc-CCCCCccceeEEEEecCCCCHHHHHhhceeeeeEeeCCCHHHhcccccceeEEEEEEecCccchhcCCCC Confidence 599999999 9999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 415 TGKIADYNYKLPDDFTGCVIAWNSNNLDSK--VGGNYNYLYRLFRKSN-----LKPFERDISTEIYQAGSTPCNGVEGFN 487 (1273) Q Consensus 415 tgkiadynyklpddftgcviawnsnnldsk--vggnynylyrlfrksn-----lkpferdisteiyqagstpcngvegfn 487 (1273) +|-|++||||+|++|+||+++|+-...+.. --++|+|+-|..+++. +.++++|++. |-... -+ T Consensus 81 sG~i~~yNYKld~s~~sC~l~~~~p~~~vnvt~ps~y~y~~~r~~~~~~~~~~~~~~~~~~cp---------c~~~~-~~ 150 (204) T 5XGR_H 81 AGAIVQFNYKQDFSNPTCRVLATVPQNLTTITKPSNYAYLTECYKTSAYGKNYLYNAPGAYTP---------CLSLA-SR 150 (204) T ss_dssp CSHHHHHTCCCCTTSCEEEEEEECCTTCCSBCCCSEEEEEEEEEEECSSSEEECCCCTTCCCT---------THHHH-TT T ss_pred CchhHhcccCCCCCCCccEEEEEcCchhcccCCccchheeeceeccccccccceeeCCCCccc---------ccccc-cC Confidence 999999999999999999999995543321 2567777777777665 5555555543 11000 23 Q sp|P0DTC2|SPIK 488 CYF---PLQS----YGFQ--PTNGVGYQPYRVVVLSFELLHAPATVCGPK 528 (1273) Q Consensus 488 cyf---plqs----ygfq--ptngvgyqpyrvvvlsfellhapatvcgpk 528 (1273) |+- |+.. +++| ...|+|+| +++|++++....+-|||.-. T Consensus 151 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~--g~~Vis~k~g~~~~~~~~~~ 198 (204) T 5XGR_H 151 GFSTKYQSHSDGELTTTGYIYPVTGNLQ--MAFIISVQYGTDTNSVCPMQ 198 (204) T ss_dssp CCSSTTCEEECSSEEEEEEEEECCSSCE--EEEEEEEECCSCTTSEEECC T ss_pred CcccCccccCCCcccccCeEeeecCccc--EEEEEEEEeCCCCCcccccc Confidence 333 3222 4453 24588888 99999999999999999643 No 36 >4QZV_B Dipeptidyl peptidase 4 (E.C.3.4.14.5), Spike; 8-BLADED BETA-PROPELLER DOMAIN, ALPHA/BETA HYDROLASE; HET: NAG, BMA; 2.592A {Homo sapiens} Probab=99.83 E-value=4.1e-25 Score=224.70 Aligned_cols=137 Identities=24% Similarity=0.439 Sum_probs=111.3 Template_Neff=3.300 Q sp|P0DTC2|SPIK 319 RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD 398 (1273) Q Consensus 319 rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyad 398 (1273) .+||...++|+++. ..|+|.++|+ .++.++|.|.|+.++||..|+++|++...+++|+||||||.||.++||..|++| T Consensus 1 ~AqP~g~V~r~~~~-~~C~~~~~l~-~~~Psp~nWeR~~fsNCnfN~S~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD 78 (246) T 4QZV_B 1 EASATGTFIEQPNA-TECDFSPMLT-GVAPQVYNFKRLVFSNCNYNLTKLLSLFAVDEFSCNGISPDSIARGCYSTLTVD 78 (246) T ss_dssp ---------------CBCCCCTTTS-SCCCCGGGCEEEEECSCBBCHHHHHTTEEEEEEEEESSCTTGGGTCCBSEEEEE T ss_pred CceeeeEEEEcCCC-CCCCChHHhc-CCCCCcceeEEEEEecCCCcHHHHHhhceeeeeEecCCCHHHHcccccceeeEE Confidence 37899999999999 9999999999 999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 399 SFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKV--GGNYNYLYRLFRK 458 (1273) Q Consensus 399 sfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskv--ggnynylyrlfrk 458 (1273) .|.|..+..++++||++|-|++||||||+||+||+++|+-.+ +..+ -++|+|+.|..++ T Consensus 79 ~FaIp~s~~~~Lq~G~sG~i~~yNYKlp~~f~gC~l~y~~~~-nvn~t~p~~y~yia~r~~~ 139 (246) T 4QZV_B 79 YFAYPLSMKSYIRPGSAGNIPLYNYKQSFANPTCRVMASVLA-NVTITKPHAYGYISKCSRL 139 (246) T ss_dssp EEECCGGGGGGGSTTCCCHCCCCCCCCCCSSCEEEEEEEECT-TSCCCCCSEEEEEEEEEEE T ss_pred EEEcchhhhhhcCCCCCCchhhccccCCCCCCceEEEEEecc-ccccCCcccceeeeeeecC Confidence 999999999999999999999999999999999999999555 2222 3455555554433 No 37 >4L3N_B S protein; beta-sheet fold, VIRAL PROTEIN; HET: NAG; 2.13A {Human betacoronavirus 2c Jordan-N3/2012} Probab=99.81 E-value=2.3e-24 Score=216.33 Aligned_cols=124 Identities=20% Similarity=0.356 Sum_probs=116.1 Template_Neff=3.200 Q sp|P0DTC2|SPIK 334 NLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPG 413 (1273) Q Consensus 334 nlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapg 413 (1273) ..|+|.++++ .++.++|.|.|+.++||..|+++|++...+++|+||||||+||.++||..|++|.|.|..+++++++|| T Consensus 3 ~~C~~~~~l~-~~~PsP~nWeR~~fsNCnfNlS~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD~FaIp~s~~~~Lq~G 81 (216) T 4L3N_B 3 VECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVS 81 (216) T ss_dssp CBCCCGGGGS-BCCCCGGGCEEEEECSEEECHHHHHHTSEEEEEEEESSCHHHHTTCCBSEEEEEEEECCGGGHHHHHTG T ss_pred CCCCchHHhc-CCCCCcceeEEEEEecCCccHHHHHhcceeeeeeecCCCHHHHhhhccceeeEEEEecChhhhhhccCC Confidence 5799999999 999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 414 QTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRK 458 (1273) Q Consensus 414 qtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrk 458 (1273) ++|-|++||||+|+||+||+++|+-.+++..+.++.+|-|+..|. T Consensus 82 ssG~i~~yNYKlp~df~gC~l~y~~~~~~vnvt~p~~y~yia~r~ 126 (216) T 4L3N_B 82 SAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCS 126 (216) T ss_dssp GGSHCCCCCCCCCSSSCEEEEEEECCTTCCSBCCCSEEEEEEEEE T ss_pred CCCchhhccccCCCCCCccEEEEEcCccccccCCCcccceeeeee Confidence 999999999999999999999999877766666677777666555 No 38 >5YY5_B MERS-CoV RBD, Heavy chain, Light; MERS-CoV, spike glycorptotein, neutralizing antibody; HET: NAG; 2.8A {Middle East respiratory syndrome coronavirus} Probab=99.81 E-value=3.5e-24 Score=214.39 Aligned_cols=124 Identities=20% Similarity=0.356 Sum_probs=115.2 Template_Neff=3.300 Q sp|P0DTC2|SPIK 334 NLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPG 413 (1273) Q Consensus 334 nlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapg 413 (1273) ..|+|.++++ .++.++|.|.|+.++||..|+++|++...+++|+||||+|.||.++||..|++|.|.|..+++++++|| T Consensus 2 ~~C~~~~~l~-~~~Psp~nWeR~~fsNCnfNlS~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD~FaIp~s~~~~Lq~G 80 (209) T 5YY5_B 2 VECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVS 80 (209) T ss_dssp CBCCCGGGGS-BCCCBGGGCEEEEECSEEECHHHHHHTSEEEEEEEESSCHHHHTTCCBSEEEEEEEECCGGGGGGSSTT T ss_pred CCCCchHHhc-CCCCCcceeEEEEEecCCccHHHHHhcceeeeeeecCCCHHHHhhhccceeeEEEEecChhhhhhccCC Confidence 4799999999 999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 414 QTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRK 458 (1273) Q Consensus 414 qtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrk 458 (1273) ++|-|++||||+|+||+||+++|+-.+++..+.++.+|-|+..|. T Consensus 81 ~sG~i~~yNYKlp~~f~gC~l~y~~~~~~vnvt~p~~y~yia~r~ 125 (209) T 5YY5_B 81 SAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCS 125 (209) T ss_dssp CCSHCCCCCCCCCSSSCEEEEEEECCTTCTTBCCCSCEEEEEEEE T ss_pred CCCchhhccccCCCCCCccEEEEEcCccccccCCCcccceeeeee Confidence 999999999999999999999999777666655666666665554 No 39 >4L72_B Dipeptidyl peptidase 4 (E.C.3.4.14.5), MERS-CoV; alpha/beta hydrolase beta-propeller, Glycolation, virus; HET: BMA, NAG; 3.005A {Homo sapiens} Probab=99.81 E-value=4e-24 Score=213.42 Aligned_cols=123 Identities=20% Similarity=0.365 Sum_probs=115.1 Template_Neff=3.300 Q sp|P0DTC2|SPIK 335 LCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQ 414 (1273) Q Consensus 335 lcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgq 414 (1273) .|+|.++++ .++.++|.|.|+.++||..|+++|++...+++|+||||+|+||.++||..|++|.|.|..+++++++||+ T Consensus 1 ~C~~~~~~~-~~~Psp~nWeR~~fsNCnfNlS~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD~FaIp~s~~~~Lq~G~ 79 (204) T 4L72_B 1 ECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSS 79 (204) T ss_pred CCChhHHhh-cCCCCcceeEEEEEecCCCCHHHHHhhceeeeeEeeCCCHHHHcccccCeeeEEEEeccccchhhcCCCC Confidence 489999999 9999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 415 TGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRK 458 (1273) Q Consensus 415 tgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrk 458 (1273) +|-|++||||+|+||+||+++|+-.+++..+.++.+|-|+..|. T Consensus 80 sG~i~~yNYKlp~~f~gC~l~y~~~~~~vnvt~p~~y~yia~r~ 123 (204) T 4L72_B 80 AGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCS 123 (204) T ss_pred CchHHhccccCCCCCCceEEEEEcCcccccCCCccccceeeeec Confidence 99999999999999999999999877666666677777666555 No 40 >3R4D_D CEA-related cell adhesion molecule 1; immunoglobulin, beta-sandwich, mCEACAM1a - immunoglobulin; HET: NAG; 3.1A {Mus musculus} Probab=99.80 E-value=5.2e-24 Score=219.92 Aligned_cols=240 Identities=20% Similarity=0.268 Sum_probs=141.9 Template_Neff=4.700 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNI------ 100 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng---tkrfdnpvlpfndgvyfasteksni------ 100 (1273) -|-.+|+||||..++|++.+-.|+||.++-++.+-.-. +|++- --.+++++.||+||+++...+++|. T Consensus 30 vs~~~G~yYp~~rvysN~t~L~qglfp~~gs~~~~y~~---t~~~~~~~~~~y~~~~~~F~dGifv~v~~~~n~~~~~~~ 106 (288) T 3R4D_D 30 VSQGLGTYYVLDRVYLNATLLLTGYYPVDGSKFRNLAL---TGTNSVSLSWFQPPYLSQFNDGIFAKVQNLKTSTPSGAT 106 (288) T ss_dssp ---------------------CEEECCCTTCCCEECCC---EESSEEEGGGSSTTTSEECTTEEEEEEECGGGGSCTTCC T ss_pred eecCeEEEEeCCeEEeceeeeecccccCCCCceEEEEe---ecCCCCccceecCCcchhcCCeEEEEeeecccCCCCccc Confidence 45578999999999999999999999999988875422 34332 2467888999999999999998875 Q sp|P0DTC2|SPIK 101 --IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMD 178 (1273) Q Consensus 101 --irgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmd 178 (1273) -..++||+|.+..+++++|+++-+...|.+|.|+.|..|.+.++..-+|.+.. +++. ..+.||+|.+. +.|-+| T Consensus 107 ~~ypa~~fGstf~n~s~tvvI~P~~~~~~it~C~~~vC~~p~~~~~p~~g~~~~~--~~~~-~~~~~c~~~~~-~nfT~d 182 (288) T 3R4D_D 107 AYFPTIVIGSLFGYTSYTVVIEPYNGVIMASVCQYTICQLPYTDCKPNTNGNKLI--GFWH-TDVKPPICVLK-RNFTLN 182 (288) T ss_dssp CCSCCEEEESSCSSSSEEEEEEEETTEEEEEEEECCBBSSCCEESSCCCTTCTTC--CSSB-CCSSCCCEEEE-EEEECC T ss_pred eecceEEEecccCCcceEEEEeCCCceEEEEEEEEEEcCCCeeEEccCCCCCcee--eeee-ecCCCCEEEEe-eeeccC Confidence 46788999999999999999999999999999999999999888744332222 3445 67889999764 445444 Q sp|P0DTC2|SPIK 179 LEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSS 255 (1273) Q Consensus 179 legkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdss 255 (1273) ...+ .|. |+|++.||.|-+|-.+...+. .+.+| |+..+.+. .+-|+..++ + T Consensus 183 ~~~~--~~~----f~F~~~~G~f~~Y~~~~~~~~~f~f~~~~-g~~~~~yy----------------vip~~~~~~---~ 236 (288) T 3R4D_D 183 VNAD--AFY----FHFYQHGGTFYAYYADKPSATTFLFSVYI-GDILTQYY----------------VLPFICNPT---A 236 (288) T ss_dssp TTCS--EEE----EEEEEETTEEEEEEESSSSCCEEEEEEEC-SSCCCEEE----------------ECCEECCCS---S T ss_pred cChh--eee----EEEEEcCCEEEEEEECCCCCceeeeccee-ccccceeE----------------EeeeeecCC---C Confidence 3321 122 999999999988877766553 55555 66555555 334444444 4 Q sp|P0DTC2|SPIK 256 SGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLK 304 (1273) Q Consensus 256 sgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlk 304 (1273) ++| ..++|||++|.+|+|||+|++||.|++||||+-|+++|-||... T Consensus 237 ~~~--~~~~~yV~~L~~r~yLl~Fd~nG~It~AvDCa~~~~sEL~~~~~ 283 (288) T 3R4D_D 237 GST--FAPRYWVTPLVKRQYLFNFNQKGVITSAVDCASSYTSEIKCKTH 283 (288) T ss_dssp CSC--CCCCEEEEECCEEEC----------------------------- T ss_pred CCc--cccEEEEEeceeeeEEEeecCCCeEeEEEEcccCcccccccccC Confidence 455 78899999999999999999999999999999999999999743 No 41 >4NJL_A S protein; six-helix-bundle, coronavirus, MERS-Cov, fusion inhibitor; HET: PGE; 2.3A {Middle East respiratory syndrome coronavirus} Probab=99.79 E-value=1.2e-23 Score=199.38 Aligned_cols=122 Identities=42% Similarity=0.571 Sum_probs=111.0 Template_Neff=2.500 Q sp|P0DTC2|SPIK 910 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEA 989 (1273) Q Consensus 910 gvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkvea 989 (1273) |+||+||.||||+||+.||.|+|.|++.+.++++||.|+|||||++++||+.|+.||+.|||||||.++||.+|||++|| T Consensus 2 gltq~VLq~NQk~iA~sFN~AignIq~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~nNFgAISSSIqdIy~RLD~LeA 81 (131) T 4NJL_A 2 GITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFQKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQ 81 (131) T ss_dssp -CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHh Confidence 78999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 990 EVQIDRLI--TGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLG 1035 (1273) Q Consensus 990 evqidrli--tgrlqslqtyvtqqliraaeirasanlaatkmsecvlg 1035 (1273) .+|++|+| .||++-+.+ +|....-+..|+.-+..|..||... T Consensus 82 Daqrl~~l~~~~~~~~~n~----~l~d~t~~~~s~~q~~~~~ne~~~~ 125 (131) T 4NJL_A 82 SGGRGGSIPNFGSLTQINT----TLLDLTYEMLSLQQVVKALNESYID 125 (131) T ss_dssp SSSCSCCCCCCCCCCCCCC----CCCCCHHHHHHHHHHHHHHHTTCCC T ss_pred HhcccchhhhhhhHHHHhH----hHHHHHHHHhhHHHHHHHHHHhccc Confidence 99999988 888776665 6666666777887788888888653 No 42 >6QFY_A Spike glycoprotein; sialic acid binding, beta-sandwich, viral; HET: NAG, BMA; 2.97A {Porcine hemagglutinating encephalomyelitis virus} Probab=99.78 E-value=2.6e-23 Score=214.69 Aligned_cols=236 Identities=20% Similarity=0.276 Sum_probs=176.2 Template_Neff=4.800 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNII----- 101 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng---tkrfdnpvlpfndgvyfasteksnii----- 101 (1273) -|-.+|+||||..++|+..+-.|+||.++-++.+-.-. +|++- --.+++++.||+||+++...+++|.- T Consensus 29 vs~~~G~yYp~~r~ysN~t~L~qglfp~~gs~~~~y~~---t~~~~~~~~~~y~~~~~~F~dGifv~v~~~~n~~~~~~~ 105 (288) T 6QFY_A 29 VTNGLGTFYVLDRVYLNTTLLLNGYYPISGATFRNMAL---KGTRLLSTLWFKSPFLSPFNDGIFAKVKNSRFSKDGVIY 105 (288) T ss_dssp CTTSTTCBCCTTCCCCSEEEEEEEEEECTTCEEEECCC---EESSCEEGGGGSTTTSEECSSEEEEEEECBCCEETTEEC T ss_pred cccCceeEecCCceeccceeeeeceecCCCCCceeeee---ecCCCCCcceecCCCcccccCcEEEEeEEeecCCCCCce Confidence 45568999999999999999999999999888875422 33332 34678889999999999999988863 Q sp|P0DTC2|SPIK 102 ---RGWIFGTTLDSKTQSLLIVNNATNV-----V---IKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEY 170 (1273) Q Consensus 102 ---rgwifgttldsktqsllivnnatnv-----v---ikvcefqfcndpflgvyyhknnkswmesefrvyssannctfey 170 (1273) -.++||+|.+..+++++|+++-+++ . |.+|.|+.|..|...++..-.| + --+++. ..+.+|+|.+ T Consensus 106 ~~yp~~~fGstf~n~s~tvvI~P~~~g~~~~~~~~~~it~C~~~vC~~p~~~~~p~~g~-~--~~~~~~-~~~~~c~~~~ 181 (288) T 6QFY_A 106 SEFPAITIGSTFVNSSHSIVVKPHTSFINGNLQGLLQISVCQYTMCEYPHTICHPNLGN-Q--RIELWH-YDTDVVSCLY 181 (288) T ss_dssp CBCCCEEEESSCSTTSCEEEEEEEE----EEEEEEEEEEEECCCEEEEEEEECCGGGCC-S--SCCEEE-CC----CSEE T ss_pred eecCceeeeccccCCceEEEEcCCCCCeeccccccceeeeeeEEecCCCeeEEcCCCCC-c--cceeeE-EecCCceEEE Confidence 3677999999999999999998864 3 6799999999999988874443 3 234555 7789999976 Q sp|P0DTC2|SPIK 171 VSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRS 247 (1273) Q Consensus 171 vsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrs 247 (1273) . +.|-+|...+ .|. |+|++.||.|-+|-.+...+. .+.+| |+..+.+. -+|..++ T Consensus 182 ~-~nfT~d~~~~--~~~----f~F~~~~G~f~~Y~~~~~~~~~f~f~~~~-~~~~~~yy-vip~~~~------------- 239 (288) T 6QFY_A 182 K-RNFTYDVNAD--YLY----FHFYQEGGTFYAYFTDTGFVTKFLFKLYL-GTVLSHYY-VMPLTCD------------- 239 (288) T ss_dssp E-ECCBCCTTCS--EEE----EEEEEETTEEEEEEESSSSSBEEEEEEEC-SSCCCEEE-ECCEECS------------- T ss_pred e-eeeccccccc--eEE----EEEEEcCCeEEEEEeccCCcceeeecCCc-ccccceeE-EceecCC------------- Confidence 4 4554444332 222 999999999988877766553 55566 66666665 2232222 Q sp|P0DTC2|SPIK 248 YLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKS 305 (1273) Q Consensus 248 yltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlks 305 (1273) ++ ..++|||++|.+|+|||+|++||.|++||||+-|+++|-||..+| T Consensus 240 --~~---------~~~~~yV~~L~~~~yLl~Fd~nG~It~AvDCa~~~~sEL~Cst~S 286 (288) T 6QFY_A 240 --SA---------LSLEYWVTPLTTRQFLLAFDQDGVLYHAVDCASDFMSEIMCKTSS 286 (288) T ss_dssp --S-------------CEEEEEEEEEEEEEEECTTCCEEEEEETTSCHHHHHHHHCCS T ss_pred --Cc---------cceeEEEEEcceeeEEEeecCCCeEeeEEEcccCcchhhccccCC Confidence 22 668999999999999999999999999999999999999998776 No 43 >4H14_A Spike glycoprotein; beta-sandwich, sugar binding, VIRAL PROTEIN; HET: NAG; 1.55A {Bovine coronavirus} Probab=99.78 E-value=3.5e-23 Score=214.01 Aligned_cols=235 Identities=21% Similarity=0.266 Sum_probs=184.1 Template_Neff=4.700 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNI------ 100 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng---tkrfdnpvlpfndgvyfasteksni------ 100 (1273) -|-.+|+||||..++|+..+-.|+||.++-++.+-.-. +|++- --.+++++.||+||+++...+++|. T Consensus 29 vs~~~G~yYp~~rvysN~t~L~qglfp~~gs~~~~y~~---t~~~~~~~~~~y~~~~~~F~dGifv~v~~~~n~~~~~~~ 105 (290) T 4H14_A 29 VTNGLGTYYVLDRVYLNTTLLLNGYYPTSGSTYRNMAL---KGTLLLSRLWFKPPFLSDFINGIFAKVKNTKVIKKGVMY 105 (290) T ss_dssp CTTSTTCBCCTTCCCCSEEEEEEEEECCTTCCCEECCC---EESSCEEGGGGSTTTSEECSSEEEEEEECEEEEETTEEE T ss_pred cccCeeEEEeCCeEEeeeeeeecceecCCCCceeeeee---eeccccccccccCCccccccCcEEEEEEeecccCCCcee Confidence 45578999999999999999999999999988875422 34332 2467888999999999999998875 Q sp|P0DTC2|SPIK 101 --IRGWIFGTTLDSKTQSLLIVNNATNV-----V---IKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEY 170 (1273) Q Consensus 101 --irgwifgttldsktqsllivnnatnv-----v---ikvcefqfcndpflgvyyhknnkswmesefrvyssannctfey 170 (1273) -..++||+|.+..+++++|+++-+++ . |.+|.|+.|..|.+.++..-.| + --+++. ..+.||+|.| T Consensus 106 ~~ypa~~fGstf~n~s~tvvI~P~~~g~~~~~~~~~~it~C~~~vC~~p~~~~~p~~g~-~--~~~~~~-~~~~~c~~~~ 181 (290) T 4H14_A 106 SEFPAITIGSTFVNTSYSVVVQPHTTNLDNKLQGLLEISVCQYTMCEYPHTICHPKLGN-K--RVELWH-WDTGVVSCLY 181 (290) T ss_dssp EECCCEEEESSCSTTSCEEEEEEEEEESSSSEEEEEEEEEECCCEEEEEEEECCGGGCC-S--SCCEEE-CCCSCCCEEE T ss_pred eecCeeEEeccccCCeeEEEEcCCCCCccchhcceeEeeeeeEEecCCCeEEEeccCCC-c--eeeeeE-EecCCceEEE Confidence 46788999999999999999998864 3 6799999999999988874443 3 234455 7789999976 Q sp|P0DTC2|SPIK 171 VSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRS 247 (1273) Q Consensus 171 vsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrs 247 (1273) . +.|-+|...+ .|. |+|++.||.|-+|-.+...+. .+.+| |+..+.+. -+|..++. T Consensus 182 ~-~nfT~d~~~~--~~~----f~F~~~~G~f~~Y~~~~~~~~~f~f~~~~-~~~~~~yy-vip~~~~~------------ 240 (290) T 4H14_A 182 K-RNFTYDVNAD--YLY----FHFYQEGGTFYAYFTDTGVVTKFLFNVYL-GTVLSHYY-VLPLTCSS------------ 240 (290) T ss_dssp E-EEEECCTTCS--EEE----EEEEEETTEEEEEEESSSSSBEEEEEEEC-SSCCCEEE-ECCEECSS------------ T ss_pred e-eeeccccccc--eee----EEEEEeCCeEEEEEEccCcccceEeccee-eeecceeE-EceeecCC------------ Confidence 4 4554544332 222 999999999988877766553 55566 66666665 23333332 Q sp|P0DTC2|SPIK 248 YLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLK 304 (1273) Q Consensus 248 yltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlk 304 (1273) + ..++|||++|.+|+|||+|++||.|++||||+-|+++|-||... T Consensus 241 ---~---------~~~~~yV~~L~~r~yLl~Fd~nG~It~AvDCa~~~~sEL~c~~~ 285 (290) T 4H14_A 241 ---A---------MTLEYWVTPLTSKQYLLAFNQDGVIFNAVDCKSDFMSEIKCKTH 285 (290) T ss_dssp ---C---------CCCCEEEEEEEEEEEEEEECTTSCEEEEEETTSSHHHHHHHHSC T ss_pred ---c---------cceeEEEEeceeeeEEEEecCCCeEeEEEecccCcchhhhcccC Confidence 1 66899999999999999999999999999999999999999753 No 44 >4MOD_B HR1 of S protein, LINKER; MERS-CoV, Viral envelope proteins, Spike; 1.901A {Human betacoronavirus 2c EMC/2012} Probab=99.75 E-value=1.9e-22 Score=191.27 Aligned_cols=118 Identities=35% Similarity=0.489 Sum_probs=66.4 Template_Neff=3.100 Q sp|P0DTC2|SPIK 918 ENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKV--EAEVQIDR 995 (1273) Q Consensus 918 enqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkv--eaevqidr 995 (1273) ||||+||+.||.|+|.|++.+.++++||.|+|||||+++++|+.|.+||..|||+|||.++||..|||++ ||.+|+|| T Consensus 2 ~NQk~iA~sFN~A~~~i~~~~~t~~~Al~kiQ~VVN~q~~aL~~l~~EL~knFkAISSsI~dIy~rld~~~~~ad~qvdr 81 (129) T 4MOD_B 2 ENQKLIANKFNQALGAMQTGFTTTNEAFQKVQDAVNNNAQALSKLASELSNTFGAISASIGDILVPRGSGGSGGSGGLEV 81 (129) T ss_dssp -CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-------------------------------- T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhCcchhhHHHhhhccCCCCCCccccchh Confidence 7999999999999999999999999999999999999999999999999999999999999999999997 89999999 Q sp|P0DTC2|SPIK 996 LITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR 1039 (1273) Q Consensus 996 litgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskr 1039 (1273) ||+|||.+|.++++.--...++++ -...+.-||+..+.+- T Consensus 82 LitgrL~~LNa~~~dl~~em~~l~----~vvk~LNes~idlkel 121 (129) T 4MOD_B 82 LFQGPLTQINTTLLDLTYEMLSLQ----QVVKALNESYIDLKEL 121 (129) T ss_dssp -------CCCCCCCCCHHHHHHHH----HHHHHHHTTCCC---- T ss_pred hcCCChHHHHHHHHHHHHHHHHHH----HHHHHHHHHhhcHHHH Confidence 999999999999876544333333 3667788888766543 No 45 >5X4R_A S protein; MERS-CoV, spike, N-terminal domain, VIRAL; HET: NAG; 1.5A {Middle East respiratory syndrome coronavirus} Probab=99.71 E-value=2.2e-21 Score=204.51 Aligned_cols=263 Identities=21% Similarity=0.314 Sum_probs=191.1 Template_Neff=4.200 Q sp|P0DTC2|SPIK 14 QCVNL-TTRTQLPPAYT----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRF 79 (1273) Q Consensus 14 qcvnl-ttrtqlppayt----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krf 79 (1273) .|... ....-+++.++ -+-.+|+||||..++++..+-.|+||.+.-++.+-.- ++|++. + -.+ T Consensus 12 ~C~~~~~~~~~~~~~~~~~idvs~~~G~yYp~~rvysN~tlL~qglfp~~gs~~~~y~---~~~~~~~~~~~~~~~~~~y 88 (342) T 5X4R_A 12 ACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANY 88 (342) T ss_dssp BCCCEEECGGGGCCCCCCCCCGGGTTTCBCCTTSCCCSEEEEEEEEECCTTCCCEEEC---CEECCBCSSCBCSEEECSG T ss_pred ceEEeccCccccCCCCCcceecccCceeEeeCCeeEeeeeeeeeccccCCCCcceEEE---EEecCCCCCCCcceeeecC Confidence 36665 23333444555 3446899999999999999999999999988887543 333333 2 356 Q sp|P0DTC2|SPIK 80 DNPVLPFNDGVYFASTEKSNIIRG-----------------WIFGTTLDSKT---Q------SLLIVNNATNVVI----- 128 (1273) Q Consensus 80 dnpvlpfndgvyfasteksniirg-----------------wifgttldskt---q------sllivnnatnvvi----- 128 (1273) +.+..||+||+++...+++|.-.+ ++||+|.+... + +++|+++-++.++ T Consensus 89 ~~~~~~F~dGifvkv~~~~n~t~~~~~~~~~~~~~~~~ypa~~fGstF~N~s~~~~~~~~~~tlvI~P~~~g~~~~~~~c 168 (342) T 5X4R_A 89 SQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYC 168 (342) T ss_dssp GGCCEECTTCEEEEESTTTTSEEECSSSTTCEEEEECCCCCEEEESCEEECTTSCEEEECSEEEEEEEETTTTEEEEEEE T ss_pred CCChhhccCeEEEEEeeeeccCCCeeecCccccchhhcccceEEecccccCCCccceeecceEEEEecCCCCceeeeEee Confidence 788999999999998887776443 57999999777 6 8999999888765 Q sp|P0DTC2|SPIK 129 --KVCEFQFCNDPFLGVYYHKNN---KSWMES---------EFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVF 194 (1273) Q Consensus 129 --kvcefqfcndpflgvyyhknn---kswmes---------efrvyssannctfeyvsqpflmdlegkqgnfknlrefvf 194 (1273) ..++..-|..|..-+++--+. -+|+.+ +++.|..+.||+|.+. +.|-+|. +.+.|. |.| T Consensus 169 ~~~prtit~C~~p~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~f~~~~nc~f~~~-~nfT~d~--~~~wf~----~~F 241 (342) T 5X4R_A 169 ILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYT-YNITEDE--ILEWFG----ITQ 241 (342) T ss_dssp EEEECCSBTSTTSTTCCCCCEEECHHHHSCTTCCCTTHHHHHHHHHEEEEEEEEEEE-EECCCCC--CCEEEE----EEE T ss_pred eeccCccccCCCCCeEeeeeecCCCCccCCCccccccccccchhhhcccCCcEEEEe-eecCcch--hhheEE----EEE Confidence 333344566666655542221 345444 6778899999999875 3444443 333444 999 Q sp|P0DTC2|SPIK 195 KNID-GYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 195 knid-gyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) ++.| |.|-+|-.++..+. ...+| |...|.+..-+|..++ ++ .+.|. ..++|||++| T Consensus 242 ~~~~~G~f~~Y~~d~~~~~~f~f~~~p-g~~~l~yy~viprs~~---------------~~---~~~~~-~~~ayyV~~L 301 (342) T 5X4R_A 242 TAQGVHLFSSRYVDLYGGNMFQFATLP-VYDTIKYYSIIPHSIR---------------SI---QSDRK-AWAAFYVYKL 301 (342) T ss_dssp ETTEEEEEESTTTCTTTCCBEEEEEEC-CCSCCCEEEECCEEEC---------------CC---GGGCC-EECCEEEEEC T ss_pred EeCCceeEEEEEEecCCCcceeccccc-cccccceeEeeeeeec---------------CC---cccce-eEEEEEEEEc Confidence 9999 99999988776653 55566 7777777664554443 22 45566 7899999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSF 306 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlksf 306 (1273) .+|+|||.||+||.|++||||+-|+++|-||..+|- T Consensus 302 ~~r~yLl~Fd~nG~It~AvDCa~d~~sELkCs~~~~ 337 (342) T 5X4R_A 302 QPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESH 337 (342) T ss_dssp EEEEEEEEECTTSCEEEEEEGGGCHHHHHHHC---- T ss_pred ceeeEEEeccCCCeEEEEEecCCCcchhhcceecCC Confidence 999999999999999999999999999999998875 No 46 >6J11_C Spike glycoprotein, VH of 7D10; MERS-CoV, Antibody, VIRAL PROTEIN; HET: MAN, NAG, BMA; 3.0A {Middle East respiratory syndrome-related coronavirus} Probab=99.70 E-value=2.8e-21 Score=203.44 Aligned_cols=262 Identities=21% Similarity=0.313 Sum_probs=192.3 Template_Neff=4.300 Q sp|P0DTC2|SPIK 14 QCVNL-TTRTQLPPAYT----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRF 79 (1273) Q Consensus 14 qcvnl-ttrtqlppayt----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krf 79 (1273) .|... ....-+++.++ -+-.+|+||||..++++..+-.|++|.+.-++.+-.- ++|++. + -.+ T Consensus 12 ~C~~~~~~~~~~~~~~~~~idvs~~~G~yYp~~rvysN~tlL~qglfp~~gs~~~~y~---~~~~~~~~~~~~~~~~~~y 88 (336) T 6J11_C 12 ACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANY 88 (336) T ss_dssp BCCCEEECGGGGCCCCCCCCCGGGTTTCBCCSSCCCCSEEEEEEEEECCTTCCCEEEC---CEECCBSSSCBCSEEECSC T ss_pred ceEEeccCccccCCCCCcceecccCceeEeeCCeeEeeeeeeeeccccCCCCcceEEE---EEecCCCCCCCcceeeecC Confidence 36664 23333444554 3446899999999999999999999999988877543 233332 2 356 Q sp|P0DTC2|SPIK 80 DNPVLPFNDGVYFASTEKSNIIRG-----------------WIFGTTLDSKT---Q------SLLIVNNATNVVI----- 128 (1273) Q Consensus 80 dnpvlpfndgvyfasteksniirg-----------------wifgttldskt---q------sllivnnatnvvi----- 128 (1273) +.+..||+||+++...+++|.-.+ ++||+|.+... + +++|+++-++.++ T Consensus 89 ~~~~~~F~dGifvkv~~~~n~t~~~~~~~~~~~~~~~~ypa~~fGstf~N~s~~~~~~~~~~tlvI~P~~~g~~~~~~~c 168 (336) T 6J11_C 89 SQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYC 168 (336) T ss_dssp TTCCEECTTCEEEEESTTTTSEEECSSSTTCEEEEECCCCCEEEESCEEECTTSCEEEECSEEEEEEEETTTTEEEEEEE T ss_pred CCChhhccCeEEEEEeeeeccCCCeeecCccccchhhcccceEEecccccCCCCcceeecceEEEEecCCCCceeeeEee Confidence 788999999999999887776443 57999999777 6 8999999888765 Q sp|P0DTC2|SPIK 129 --KVCEFQFCNDPFLGVYYHKNN---KSWMES---------EFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVF 194 (1273) Q Consensus 129 --kvcefqfcndpflgvyyhknn---kswmes---------efrvyssannctfeyvsqpflmdlegkqgnfknlrefvf 194 (1273) +.++..-|..|..-+++.-+. -+|+.+ +++.|..+.||+|.+.. .|-+|. +.+.|. |.| T Consensus 169 ~~~~rtit~C~~p~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~f~~~~nc~f~~~~-nft~d~--~~~wf~----~~F 241 (336) T 6J11_C 169 ILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYTY-NITEDE--ILEWFG----ITQ 241 (336) T ss_dssp EEEECCSBTSTTSTTCCCCCEEECHHHHCSSSSCCTTHHHHHHHHHEEEEEEEEEEEE-ECCCCC--CCEEEE----EEE T ss_pred eeccCccccCCCCCeEeeeeecCCCCccCCCccccccccccchhhhcccCCcEEEEee-ecCcch--hhheEe----EEE Confidence 333344566666655542221 345444 67788999999998753 444443 333443 999 Q sp|P0DTC2|SPIK 195 KNIDG-YFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 195 knidg-yfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) ++.|| .|-+|--++..+. ...+| |...|.+..-+|..++ ++ .+.|. ..++|||++| T Consensus 242 ~~~~G~~f~~Y~~d~~~~~~f~f~~~~-g~~~l~yy~vip~s~~---------------~~---~~~~~-~~~ayyV~~L 301 (336) T 6J11_C 242 TAQGVHLFSSRYVDLYGGNMFQFATLP-VYDTIKYYSIIPHSIR---------------SI---QSDRK-AWAAFYVYKL 301 (336) T ss_dssp ETTEEEEEESTTTCTTTCCBEEEEEEC-CCSCCCEEEECCEEEC---------------CC---STTCC-EECCEEEEEC T ss_pred EeCCeeEEEEEEEccCCCcceeccccc-ceeccceeEeeeeeec---------------CC---cccce-eEEEEEEEEc Confidence 99999 9999887766653 55566 7777777664554443 22 45566 7899999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKS 305 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlks 305 (1273) .+|+|||.||+||.|++||||+-|+++|-||..+| T Consensus 302 ~~~~yLl~Fd~nG~It~AvDCa~d~~sELkCst~S 336 (336) T 6J11_C 302 QPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYES 336 (336) T ss_dssp EEEEEEEEECSSSCEEEEEETTSSHHHHHHHHHCC T ss_pred ceeeEEEeccCCCeEEEEEecCCCcchhheeeecC Confidence 99999999999999999999999999999998764 No 47 >5GYQ_A Spike glycoprotein; bat coronavirus HKU9, putative receptor; HET: NAG; 2.1A {Bat coronavirus HKU9} Probab=99.70 E-value=4.2e-21 Score=188.88 Aligned_cols=108 Identities=29% Similarity=0.580 Sum_probs=104.5 Template_Neff=2.900 Q sp|P0DTC2|SPIK 332 ITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIA 411 (1273) Q Consensus 332 itnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqia 411 (1273) |...|+|.++++ .++.+++.|.|+.++||..|+++|++.....+|+||||||.||.+.||..|+.|.|.|..+..++++ T Consensus 2 ~~~~C~~~~~l~-~~~PsP~nWeR~~fsNCnFN~S~Llslv~v~sf~C~gISPskLasmCfsSVTiD~FaIp~s~~~~Lq 80 (176) T 5GYQ_A 2 IQSYCTPPYSVL-QDPPQPVVWRRYMLYDCVFDFTVVVDSLPTHQLQCYGVSPRRLASMCYGSVTLDVMRINETHLNNLF 80 (176) T ss_dssp CCEECCCCHHHH-HSCCCGGGCEEEEECSEEECGGGGTTSSCEEEEEEESSCHHHHTTSCBSEEEEEEEEECHHHHHHHH T ss_pred CCCCCCCChHhc-CCCCCCceeEEEEEeccCCchHHHHhhceeeeeeeeCCCHHHHhhcccceeEEEEEEeChHHHHhhc Confidence 567899999999 9999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 412 PGQTGKIADYNYKLPDDFTGCVIAWNSNN 440 (1273) Q Consensus 412 pgqtgkiadynyklpddftgcviawnsnn 440 (1273) +|++|-|++||||+|+||+||+++|+-+. T Consensus 81 ~GssG~i~~yNYKlp~~f~gC~l~y~l~~ 109 (176) T 5GYQ_A 81 NRVPDTFSLYNYALPDNFYGCLHAFYLNS 109 (176) T ss_dssp HTCCCHHHHHTCCCCTTCCEEEEEEEEEE T ss_pred CCCCcHHHhccccCCCCCCceEEEEEcCC Confidence 99999999999999999999999997653 No 48 >5ZVK_A Human Coronavirus MERS HR1 motif; MERS, Spike protein, S2 domain; 3.31A {Middle East respiratory syndrome-related coronavirus} Probab=99.68 E-value=7.3e-21 Score=169.61 Aligned_cols=79 Identities=56% Similarity=0.816 Sum_probs=69.9 Template_Neff=3.000 Q sp|P0DTC2|SPIK 910 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVE 988 (1273) Q Consensus 910 gvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkve 988 (1273) |+|++||.||||+||+.||.|+|.|++.+.++++||.|+|||||++++||+.|+.||+.|||||||.++||.+|||++| T Consensus 2 glt~~VL~~NQk~iA~sFN~A~~~i~~~~~t~~~AL~kiQ~VVN~q~~aL~~L~~qL~~NFgAISssI~dIy~RLd~le 80 (80) T 5ZVK_A 2 GITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFRKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLE 80 (80) T ss_dssp --CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC------- T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHhcC Confidence 7899999999999999999999999999999999999999999999999999999999999999999999999999986 No 49 >2BEZ_C E2 GLYCOPROTEIN; MEMBRANE FUSION, SEVERE ACUTE RESPIRATORY; 1.6A {SARS CORONAVIRUS} SCOP: h.3.3.1 Probab=99.63 E-value=8.5e-20 Score=162.03 Aligned_cols=77 Identities=88% Similarity=1.101 Sum_probs=75.2 Template_Neff=3.000 Q sp|P0DTC2|SPIK 914 NVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAE 990 (1273) Q Consensus 914 nvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveae 990 (1273) +||.||||+||+.||.|++.|+..++++++||.|+|||||++++||+.|+.||+.|||||||.++||.+|||++||. T Consensus 1 ~VL~~NQk~iA~sFN~A~~~i~~~~~t~s~AL~kiQ~VVN~q~~aL~~L~~qL~~nFgAISssI~dIy~RLd~leAd 77 (77) T 2BEZ_C 1 NVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAE 77 (77) T ss_dssp CCSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred ChhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHhcC Confidence 58999999999999999999999999999999999999999999999999999999999999999999999999984 No 50 >6M1V_A spike protein; 2019-nCoV, spike protein, fusion core; 1.5A {Severe acute respiratory syndrome coronavirus 2} Probab=99.60 E-value=2.8e-19 Score=168.19 Aligned_cols=98 Identities=56% Similarity=0.575 Sum_probs=68.4 Template_Neff=3.400 Q sp|P0DTC2|SPIK 917 YENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRL 996 (1273) Q Consensus 917 yenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrl 996 (1273) .||||+||+.||.|+|.|++.++++++||.|+|||||++++||+.|+.||+.|||||||.+. |++||.+|+||+ T Consensus 1 ~~NQk~lA~sFN~A~~~i~~~~~t~~~Al~kiQ~VVN~q~~aL~~L~~qL~~nf~aisssi~------~~lea~~q~drl 74 (119) T 6M1V_A 1 MENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLLVPRGSGGSGGS------GGLEVLFQGPDV 74 (119) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCC-------------------------- T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhccCCCcchhh------hhHHHhhcCCCc Confidence 38999999999999999999999999999999999999999999999999999999999977 899999999999 Q sp|P0DTC2|SPIK 997 ITGRLQSLQTYVTQQLIRAAEIRA 1020 (1273) Q Consensus 997 itgrlqslqtyvtqqliraaeira 1020 (1273) ++|||..+..++++-....++++. T Consensus 75 itgrLsaLNatvldL~~Ei~~Lqe 98 (119) T 6M1V_A 75 DLGDISGINASVVNIQKEIDRLNE 98 (119) T ss_dssp ----CTTCCCCCCCCHHHHHHHHH T ss_pred CCCChHHhhHHHHHHHHHHHHHHH Confidence 999999999999887666655543 No 51 >5ZUV_A Spike glycoprotein,EK1, Spike glycoprotein,inhibitor EK1; Human Coronavirus 229E, Spike protein; 2.21A {Human coronavirus 229E} Probab=99.56 E-value=1.2e-18 Score=166.05 Aligned_cols=83 Identities=47% Similarity=0.646 Sum_probs=77.2 Template_Neff=2.400 Q sp|P0DTC2|SPIK 914 NVLYENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLND 979 (1273) Q Consensus 914 nvlyenqklianqfnsaigkiqds--------------lsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlnd 979 (1273) +||.||||+||+.||.|||.|+.. ++++++||.|+|||||++++||+.|++||+.|||||||.++| T Consensus 2 dVLq~NQkiiA~SFN~AignI~~aF~~vn~ai~qts~~~~Tva~AL~KIQdVVN~qg~AL~~Lt~QL~nNFqAISSSIqD 81 (133) T 5ZUV_A 2 DVLQENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQAISSSIQA 81 (133) T ss_dssp --CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 689999999999999999999966 566779999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 980 ILSRLDKVEAEVQIDRL 996 (1273) Q Consensus 980 ilsrldkveaevqidrl 996 (1273) |.+|||++||.++.++| T Consensus 82 IY~RLD~leAd~~~gsl 98 (133) T 5ZUV_A 82 IYDRLDTIQSGGRGGSL 98 (133) T ss_dssp HHHHHTCSSCCCCSCCC T ss_pred HHHHHHHHHhhhccCcc Confidence 99999999999998776 No 52 >5YL9_A Spike glycoprotein; Spike protein, 6-helical bundle, post-fusion; 1.861A {Human coronavirus 229E} Probab=99.49 E-value=1.1e-17 Score=151.89 Aligned_cols=74 Identities=51% Similarity=0.726 Sum_probs=70.0 Template_Neff=2.900 Q sp|P0DTC2|SPIK 914 NVLYENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLND 979 (1273) Q Consensus 914 nvlyenqklianqfnsaigkiqds--------------lsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlnd 979 (1273) +||.||||+||+.||.|||.|+.. ++++++||.|+|||||++++||+.|.+||+.|||||||.++| T Consensus 2 ~VLq~NQk~iA~sFN~Aigni~~af~~vn~ai~qts~~~~tva~AL~KiQ~VVN~q~~aL~~Lt~QL~~NF~AISsSI~d 81 (89) T 5YL9_A 2 DVLQENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQAISSSIQA 81 (89) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 689999999999999999999977 556679999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 980 ILSRLDKV 987 (1273) Q Consensus 980 ilsrldkv 987 (1273) |.+|||++ T Consensus 82 Iy~RLd~l 89 (89) T 5YL9_A 82 IYDRLDTI 89 (89) T ss_dssp HHHHHHHC T ss_pred HHHHHhcC Confidence 99999974 No 53 >1WDF_B E2 glycoprotein; MHV, coronavirus, heptad repeat, fusion; 2.5A {Murine hepatitis virus} SCOP: h.3.3.1 Probab=99.16 E-value=2.7e-14 Score=131.27 Aligned_cols=62 Identities=60% Similarity=0.836 Sum_probs=58.6 Template_Neff=2.400 Q sp|P0DTC2|SPIK 919 NQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDI 980 (1273) Q Consensus 919 nqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndi 980 (1273) |||.||+.||.|||.||+.++++++||.|+|||||++++||+.|+.||+.|||||||++.|. T Consensus 1 NQkiLAnsFN~AignIq~af~tts~AL~KIQdVVN~qg~AL~~Lt~QL~~NFgAISSsi~d~ 62 (95) T 1WDF_B 1 NQKMIASAFNNALGAIQDGFDATNSALGKIQSVVNANAEALNNLLNQLSNRFGAISDLSLDF 62 (95) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCC--CCCCCG T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHchHHHHHHHH Confidence 79999999999999999999999999999999999999999999999999999999999875 No 54 >1ZVA_A E2 glycoprotein; SARS coronavirus, membrane fusion, S2; 1.5A {SARS coronavirus} SCOP: h.3.3.1 Probab=99.05 E-value=1.7e-13 Score=121.91 Aligned_cols=58 Identities=66% Similarity=0.811 Sum_probs=47.6 Template_Neff=4.100 Q sp|P0DTC2|SPIK 1144 ELDSFKEELDKYFKNHTSPDVDLGD-----ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 1201 (1273) Q Consensus 1144 eldsfkeeldkyfknhtspdvdlgd-----isginasvvniqkeidrlnevaknlneslidlq 1201 (1273) .|..|++||+|+||+++|.-.|+.+ ++++|+++++++.||+||+||+|+||||+|||+ T Consensus 15 ~L~~f~~eL~~~FkaiSSsi~di~~rl~grLs~lNa~vl~l~~Ei~~L~~vik~LN~S~IdLk 77 (77) T 1ZVA_A 15 ALNTLVKQLSSNFGAISSVLNDISGGRGGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 77 (77) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHTTSCCCCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHC-- T ss_pred HHHHHHHHHHHHhchhhhchhhhcCCCCCChhhhcHHHHHHHHHHHHHHHHHHHHHHhhhccC Confidence 4566777777777777776655554 999999999999999999999999999999985 No 55 >5ZHY_D Spike glycoprotein,Spike glycoprotein; membrane fusion, broad-spectrum inhibitor design; 2.441A {Human coronavirus 229E} Probab=98.79 E-value=7.4e-12 Score=121.97 Aligned_cols=59 Identities=47% Similarity=0.667 Sum_probs=37.2 Template_Neff=2.300 Q sp|P0DTC2|SPIK 918 ENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSV 976 (1273) Q Consensus 918 enqklianqfnsaigkiqds--------------lsstasalgklqdvvnqnaqalntlvkqlssnfgaissv 976 (1273) ||||+||+.||.|||.|+.. ++++|+||.|+|||||+.++||+.|.+||+.||||||+- T Consensus 1 ~NQkiLAnSFN~AignIt~aF~~Vn~Ai~qts~~~~Tva~AL~KIQdVVN~Qg~ALs~Lt~QL~nNFqAIS~~ 73 (148) T 5ZHY_D 1 ENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQLVPRG 73 (148) T ss_dssp -----CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCC-------------- T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCcccc Confidence 69999999999999999966 555679999999999999999999999999999999974 No 56 >5XJK_A Spike protein S2; VIRAL PROTEIN; NMR {Human SARS coronavirus} Probab=98.74 E-value=1.4e-11 Score=106.98 Aligned_cols=62 Identities=85% Similarity=1.326 Sum_probs=57.8 Template_Neff=4.400 Q sp|P0DTC2|SPIK 777 NTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYG 838 (1273) Q Consensus 777 ntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedllfnkvtladagfikqyg 838 (1273) +..+++..+|+-+++|-+..|+||||+.+||.+++++.||+||||||+||.++|.||++.|. T Consensus 3 ~~~~~~s~~~~~~~l~~~~~~~~fN~s~lL~~~~~~~~RSaIEDLLF~KV~t~~~G~v~~Yk 64 (65) T 5XJK_A 3 NTREVFAQVKQMYKTPTLKYFGGFNFSQILPSPLKPTKRSFIEDLLFNKVTLADAGFMKQYG 64 (65) T ss_dssp TTGGGHHHHTTCCCCCCCSSSCCCCGGGSSCCCCCCCGGGGGGHHHHTTTSSTTHHHHHGGG T ss_pred cHHHHHHHHHHHhcCCcccccCCccccccCCCCCCCCCccHHHHHhccceeecCcchhhhhc Confidence 34678899999999999999999999999999999999999999999999999999998885 No 57 >1ZV8_K E2 glycoprotein; SARS coronavirus, membrane fusion, S2; 1.94A {SARS coronavirus} SCOP: h.3.3.1 Probab=98.55 E-value=1.2e-10 Score=98.26 Aligned_cols=50 Identities=82% Similarity=0.987 Sum_probs=48.5 Template_Neff=3.100 Q sp|P0DTC2|SPIK 919 NQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSS 968 (1273) Q Consensus 919 nqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlss 968 (1273) |||+||+.||.||+.|++.++++++||.|+|||||++++||+.|..||+. T Consensus 1 NQk~iA~sFN~Ai~~i~~g~~t~~~AL~KiQ~VVN~q~~aL~~Lt~qL~~ 50 (50) T 1ZV8_K 1 NQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSS 50 (50) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhC Confidence 79999999999999999999999999999999999999999999999963 No 58 >2IEQ_B Spike glycoprotein; Human coronavirus membrane fusion; 1.747A {Human coronavirus} Probab=98.54 E-value=1.3e-10 Score=109.56 Aligned_cols=84 Identities=33% Similarity=0.293 Sum_probs=64.1 Template_Neff=3.500 Q sp|P0DTC2|SPIK 921 KLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISS-VLNDIL--------SRLDKVEAEV 991 (1273) Q Consensus 921 klianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaiss-vlndil--------srldkveaev 991 (1273) .+-.+.||.||+.||+.++++++||.|+|||||+.+++|+.|..||..||++|+. .+ ||. +|+|+.|++. T Consensus 7 t~a~~~fn~Ai~~i~~g~~tt~~AL~KIQ~VVN~q~~tL~~Ll~QL~nNF~Ais~~~l-difN~T~LNLT~Ei~~LE~ra 85 (109) T 2IEQ_B 7 VASFSSVNDAITQTAEAIHTVTIALNKIQDVVNQQGSALNHLTSQLRHNFQSGGRGSG-RGGNLTYLNLSSELKQLEAKT 85 (109) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-----------------CCCCCCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcccCCCCccCC-cchHhhhcchhHHHHHHHHHH Confidence 3456899999999999999999999999999999999999999999999999999 67 999 9999999999 Q sp|P0DTC2|SPIK 992 QIDRLITGRLQSLQ 1005 (1273) Q Consensus 992 qidrlitgrlqslq 1005 (1273) +-=+-++-.||.+- T Consensus 86 ~~L~~~~~eLq~~I 99 (109) T 2IEQ_B 86 ASLFQTTVELQGLI 99 (109) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88888888877653 No 59 >2FXP_A Spike glycoprotein; Prefusion Intermediate, Trimer, Coiled-coil, VIRAL; NMR {SARS coronavirus} SCOP: h.3.3.1 Probab=98.52 E-value=1.6e-10 Score=98.19 Aligned_cols=54 Identities=98% Similarity=1.317 Sum_probs=52.8 Template_Neff=4.100 Q sp|P0DTC2|SPIK 1158 NHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 1211 (1273) Q Consensus 1158 nhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyik 1211 (1273) |||+|+.++.++..+|++++|++.||++|+++.|+||+++|||++|++||+||| T Consensus 2 n~t~~~~~~~~l~~~N~t~LnLt~Ei~~Lq~~I~~LN~s~IdLe~Ln~~etYiK 55 (55) T 2FXP_A 2 SHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 55 (55) T ss_dssp CSCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTCCC T ss_pred CCCCCCCCCCccccccccccchHHHHHHHHHHHHHHhhcCCCHHHhccceeecC Confidence 799999999999999999999999999999999999999999999999999998 No 60 >1WDG_B E2 glycoprotein; MHV, coronavirus, heptad repeat, fusion; 2.06A {Murine hepatitis virus} SCOP: h.3.3.1 Probab=98.49 E-value=2.2e-10 Score=106.06 Aligned_cols=54 Identities=57% Similarity=0.760 Sum_probs=48.6 Template_Neff=3.000 Q sp|P0DTC2|SPIK 919 NQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSS--NFGA 972 (1273) Q Consensus 919 nqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlss--nfga 972 (1273) |||+||+.||.|||.||+.++++++||.|+|||||++++||+.|..||+. |++. T Consensus 1 NQk~iA~sFN~Aigni~~~f~~~~~AL~kiQ~VVN~q~~aL~~LtNQLS~~pn~~~ 56 (94) T 1WDG_B 1 NQKMIASAFNNALGAIQDGFDATNSALGKIQSVVNANAEALNNLLNQLSLVPRGSG 56 (94) T ss_dssp -CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCC------ T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCC Confidence 79999999999999999999999999999999999999999999999998 7777 No 61 >2BEQ_D E2 GLYCOPROTEIN; VIRAL PROTEIN, COILED COIL, MEMBRANE; HET: ACE; 1.6A {N/A} Probab=98.41 E-value=5.2e-10 Score=93.68 Aligned_cols=47 Identities=98% Similarity=1.271 Sum_probs=44.9 Template_Neff=3.400 Q sp|P0DTC2|SPIK 1166 LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKW 1212 (1273) Q Consensus 1166 lgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyikw 1212 (1273) ++|++.+|++++|++.||++|+++.|+||+|+|||++|++||+|||| T Consensus 2 ~~~l~~~N~t~LnLs~Ei~~Lq~~I~~LN~s~IdLe~Ln~~etYiKW 48 (48) T 2BEQ_D 2 LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKX 48 (48) T ss_dssp CCSCTTCCCCCCCCHHHHHHHHHHHTTGGGGEECHHHHHHHHHHHC- T ss_pred CCCccccccccccHHHHHHHHHHHHHHHHhcCCCHHHhcccchhcCC Confidence 67889999999999999999999999999999999999999999999 No 62 >2BEQ_E E2 GLYCOPROTEIN; VIRAL PROTEIN, COILED COIL, MEMBRANE; HET: ACE; 1.6A {N/A} Probab=98.41 E-value=5.2e-10 Score=93.68 Aligned_cols=47 Identities=98% Similarity=1.271 Sum_probs=44.3 Template_Neff=3.400 Q sp|P0DTC2|SPIK 1166 LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKW 1212 (1273) Q Consensus 1166 lgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyikw 1212 (1273) ++|++.+|++++|++.||++|+++.|+||+|+|||++|++||+|||| T Consensus 2 ~~~l~~~N~t~LnLs~Ei~~Lq~~I~~LN~s~IdLe~Ln~~etYiKW 48 (48) T 2BEQ_E 2 LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKX 48 (48) T ss_dssp -CTTTTCCCCCCCCHHHHHHHHHHHHTGGGTEEEHHHHHHHHHHHC- T ss_pred CCCccccccccccHHHHHHHHHHHHHHHHhcCCCHHHhcccchhcCC Confidence 67889999999999999999999999999999999999999999999 No 63 >6LXT_F Spike protein S2; 2019-nCoV, HR1 and HR2 domain; HET: PG4; 2.9A {Severe acute respiratory syndrome coronavirus 2} Probab=97.71 E-value=1.4e-07 Score=91.83 Aligned_cols=45 Identities=98% Similarity=1.275 Sum_probs=36.7 Template_Neff=2.500 Q sp|P0DTC2|SPIK 1163 DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE 1207 (1273) Q Consensus 1163 dvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkye 1207 (1273) .+..|.++.+||.|...|.|+.+|||||||||||||||||||||. T Consensus 87 RLItGRLaaLna~v~q~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 131 (132) T 6LXT_F 87 DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYG 131 (132) T ss_dssp ---CCCCTTCCCCCCCCHHHHHHHHHHHHHGGGGSCCCCC----- T ss_pred chhcccHHHHHHHHHHHHHHHHHHHHHHHHHhHHhchHHHhHhcC Confidence 467899999999999999999999999999999999999999994 No 64 >6LXT_C 2019-nCoV S2 subunit; 2019-nCoV, HR1 and HR2 domain; HET: PG4; 2.9A {COVID-19 virus} Probab=97.71 E-value=1.4e-07 Score=91.83 Aligned_cols=45 Identities=98% Similarity=1.275 Sum_probs=38.5 Template_Neff=2.500 Q sp|P0DTC2|SPIK 1163 DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE 1207 (1273) Q Consensus 1163 dvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkye 1207 (1273) .+..|.++.+||.|...|.|+.+|||||||||||||||||||||. T Consensus 87 RLItGRLaaLna~v~q~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 131 (132) T 6LXT_C 87 DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYG 131 (132) T ss_dssp CCCCCCCTTCCCCCCCCHHHHHHHHHHHHHGGGGCCCCCC----- T ss_pred chhcccHHHHHHHHHHHHHHHHHHHHHHHHHhHHhchHHHhHhcC Confidence 467899999999999999999999999999999999999999994 No 65 >4MOD_B HR1 of S protein, LINKER; MERS-CoV, Viral envelope proteins, Spike; 1.901A {Human betacoronavirus 2c EMC/2012} Probab=97.52 E-value=4.8e-07 Score=88.04 Aligned_cols=64 Identities=33% Similarity=0.482 Sum_probs=36.9 Template_Neff=3.100 Q sp|P0DTC2|SPIK 1142 QPELDSFKEELDKYFKNHTSPDVDL--------------------GDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 1201 (1273) Q Consensus 1142 qpeldsfkeeldkyfknhtspdvdl--------------------gdisginasvvniqkeidrlnevaknlneslidlq 1201 (1273) ...|..|++||+++||+++|.-.|+ |.++.+|+++++++.|+.+|++|.|.||||.|||+ T Consensus 40 ~~aL~~l~~EL~knFkAISSsI~dIy~rld~~~~~ad~qvdrLitgrL~~LNa~~~dl~~em~~l~~vvk~LNes~idlk 119 (129) T 4MOD_B 40 AQALSKLASELSNTFGAISASIGDILVPRGSGGSGGSGGLEVLFQGPLTQINTTLLDLTYEMLSLQQVVKALNESYIDLK 119 (129) T ss_dssp HHHHHHHHHC---------------------------------------CCCCCCCCCHHHHHHHHHHHHHHHTTCCC-- T ss_pred HHHHHHHHHHHHHHhCcchhhHHHhhhccCCCCCCccccchhhcCCChHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcHH Confidence 3568899999999999999987776 45777999999999999999999999999999999 Q sp|P0DTC2|SPIK 1202 ELGK 1205 (1273) Q Consensus 1202 elgk 1205 (1273) ||-. T Consensus 120 el~~ 123 (129) T 4MOD_B 120 ELLE 123 (129) T ss_dssp ---- T ss_pred HHHh Confidence 9854 No 66 >1ZVB_A E2 glycoprotein; SARS coronavirus, membrane fusion, S2; 1.7A {SARS coronavirus} SCOP: h.3.3.1 Probab=97.29 E-value=1.9e-06 Score=69.03 Aligned_cols=34 Identities=100% Similarity=1.192 Sum_probs=32.0 Template_Neff=3.100 Q sp|P0DTC2|SPIK 958 ALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEV 991 (1273) Q Consensus 958 alntlvkqlssnfgaissvlndilsrldkveaev 991 (1273) ||+.|+.||+.|||||||.++||.+|||++||.+ T Consensus 1 al~~L~~qL~nnF~aISssI~di~~RLD~leA~~ 34 (34) T 1ZVB_A 1 ALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEV 34 (34) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTC T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcC Confidence 5889999999999999999999999999999864 No 67 >1WDG_B E2 glycoprotein; MHV, coronavirus, heptad repeat, fusion; 2.06A {Murine hepatitis virus} SCOP: h.3.3.1 Probab=97.10 E-value=5.1e-06 Score=77.92 Aligned_cols=47 Identities=30% Similarity=0.468 Sum_probs=29.3 Template_Neff=3.000 Q sp|P0DTC2|SPIK 1156 FKNHTSPDVDLGD----ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQE 1202 (1273) Q Consensus 1156 fknhtspdvdlgd----isginasvvniqkeidrlnevaknlneslidlqe 1202 (1273) .-++++...++++ +++||++.+++++|+++|+||.|.||||.|||+| T Consensus 44 LtNQLS~~pn~~~~~~~~~~iN~t~lDl~~Em~~lq~vvk~LNeS~IdLKe 94 (94) T 1WDG_B 44 LLNQLSLVPRGSGGSGGSGGLNVTLLDLTYEMNRIQDAIKKLNESYINLKE 94 (94) T ss_dssp HHTTCCC-------------------CCHHHHHHHHHHHHHHHTTCCCTTC T ss_pred HHHHHhcCCCCCCCCCCcccchhhhHHHHHHHHHHHHHHHHHHHHhhcccC Confidence 4577777777777 9999999999999999999999999999999986 No 68 >6M1V_A spike protein; 2019-nCoV, spike protein, fusion core; 1.5A {Severe acute respiratory syndrome coronavirus 2} Probab=96.99 E-value=8.6e-06 Score=78.78 Aligned_cols=49 Identities=86% Similarity=1.074 Sum_probs=35.8 Template_Neff=3.400 Q sp|P0DTC2|SPIK 1157 KNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGK 1205 (1273) Q Consensus 1157 knhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgk 1205 (1273) .+-+.+..++|+++.+|+++++++.||++|+||.|+||||+|||+||.. T Consensus 67 a~~q~drlitgrLsaLNatvldL~~Ei~~LqevIk~LN~S~IDLk~~~~ 115 (119) T 6M1V_A 67 VLFQGPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELHH 115 (119) T ss_dssp ------------CTTCCCCCCCCHHHHHHHHHHHHHGGGGSCCGGGSCC T ss_pred HhhcCCCcCCCChHHhhHHHHHHHHHHHHHHHHHHHHHHHcccHHHhhc Confidence 3456677888999999999999999999999999999999999999864 No 69 >2BEQ_C E2 GLYCOPROTEIN; VIRAL PROTEIN, COILED COIL, MEMBRANE; HET: ACE; 1.6A {N/A} SCOP: h.3.3.1 Probab=96.96 E-value=9.9e-06 Score=66.07 Aligned_cols=36 Identities=81% Similarity=0.995 Sum_probs=34.2 Template_Neff=3.500 Q sp|P0DTC2|SPIK 932 GKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLS 967 (1273) Q Consensus 932 gkiqdslsstasalgklqdvvnqnaqalntlvkqls 967 (1273) +.||+.++++++||.|+|||||++++||+.|.+||+ T Consensus 2 ~~iq~gf~tta~AL~KIQ~VVN~qg~aL~~Lt~QL~ 37 (38) T 2BEQ_C 2 SQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLS 37 (38) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhC Confidence 568999999999999999999999999999999996 No 70 >5ZVM_c Human Coronavirus SARS HR1 motif; SARS, Spike protein, S2 domain; 3.3A {Human SARS coronavirus} Probab=96.74 E-value=2.6e-05 Score=65.26 Aligned_cols=41 Identities=39% Similarity=0.648 Sum_probs=38.1 Template_Neff=3.500 Q sp|P0DTC2|SPIK 1165 DLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGK 1205 (1273) Q Consensus 1165 dlgdisginasvvniqkeidrlnevaknlneslidlqelgk 1205 (1273) .++|+..+|++++|++.||++|+++.|+||+++|||++|++ T Consensus 4 ~~~~l~~~N~t~LnLt~Ei~~Lq~~Ik~LN~s~IDLe~Lnr 44 (44) T 5ZVM_c 4 RGGSLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGG 44 (44) T ss_dssp HHHCCTTCCCCCCCCHHHHHHHHHHHHHHHTTCCCCCCCTT T ss_pred CCCChhhccccccchHHHHHHHHHHHHHHHhhcCCHHHhCC Confidence 46788899999999999999999999999999999999874 No 71 >5ZVM_b Human Coronavirus SARS HR1 motif; SARS, Spike protein, S2 domain; 3.3A {Human SARS coronavirus} Probab=96.74 E-value=2.6e-05 Score=65.26 Aligned_cols=41 Identities=39% Similarity=0.648 Sum_probs=38.1 Template_Neff=3.500 Q sp|P0DTC2|SPIK 1165 DLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGK 1205 (1273) Q Consensus 1165 dlgdisginasvvniqkeidrlnevaknlneslidlqelgk 1205 (1273) .++|+..+|++++|++.||++|+++.|+||+++|||++|++ T Consensus 4 ~~~~l~~~N~t~LnLt~Ei~~Lq~~Ik~LN~s~IDLe~Lnr 44 (44) T 5ZVM_b 4 RGGSLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGG 44 (44) T ss_pred CCCChhhcccccccHHHHHHHHHHHHHHHHhhccChHHhcC Confidence 46788899999999999999999999999999999999874 No 72 >2BEZ_F E2 GLYCOPROTEIN; MEMBRANE FUSION, SEVERE ACUTE RESPIRATORY; 1.6A {SARS CORONAVIRUS} Probab=96.44 E-value=8.7e-05 Score=61.42 Aligned_cols=42 Identities=100% Similarity=1.270 Sum_probs=37.4 Template_Neff=4.100 Q sp|P0DTC2|SPIK 1160 TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 1201 (1273) Q Consensus 1160 tspdvdlgdisginasvvniqkeidrlnevaknlneslidlq 1201 (1273) ||+..++.++..+|++++|++.||++|+++.|+||+++|||+ T Consensus 1 ts~~p~~~~l~~~N~t~LnLt~Ei~~Lq~~I~~LN~slIdLe 42 (42) T 2BEZ_F 1 TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 42 (42) T ss_dssp CCCCCCCCCCTTCCCCCCCCHHHHHHHHHHHHHTSTTSCCCC T ss_pred CCCCcCcccccccccccccHHHHHHHHHHHHHHHHhccccCC Confidence 455566666889999999999999999999999999999985 No 73 >6LVN_B 2019-nCoV S2 subunit; 2019-nCoV, HR2 domain, VIRUS, VIRAL; 2.47A {COVID-19 virus} Probab=96.21 E-value=0.00019 Score=58.12 Aligned_cols=35 Identities=100% Similarity=1.213 Sum_probs=32.6 Template_Neff=3.900 Q sp|P0DTC2|SPIK 1169 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1169 isginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) +..+|++++|++.||++|+++.|+||+|+|||++| T Consensus 2 ~~~~N~t~Lnlt~Ei~~lq~~I~~LN~s~IdLe~L 36 (36) T 6LVN_B 2 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 (36) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTC T ss_pred CcccccccccHHHHHHHHHHHHHHHHhhcCChhhC Confidence 45689999999999999999999999999999875 No 74 >1ZV8_B E2 glycoprotein; SARS coronavirus, membrane fusion, S2; 1.94A {SARS coronavirus} Probab=96.21 E-value=0.00019 Score=58.12 Aligned_cols=35 Identities=100% Similarity=1.213 Sum_probs=26.7 Template_Neff=3.900 Q sp|P0DTC2|SPIK 1169 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1169 isginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) +..+|++++|++.||++|+++.|+||+|+|||++| T Consensus 2 ~~~~N~t~Lnlt~Ei~~lq~~I~~LN~s~IdLe~L 36 (36) T 1ZV8_B 2 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 (36) T ss_dssp ---CCCCCCCCHHHHHHHHHHHHHGGGGCC----- T ss_pred CcccccccccHHHHHHHHHHHHHHHHhhcCChhhC Confidence 45689999999999999999999999999999875 No 75 >6LVN_A Spike protein S2; 2019-nCoV, HR2 domain, VIRUS, VIRAL; 2.47A {Severe acute respiratory syndrome coronavirus 2} Probab=96.21 E-value=0.00019 Score=58.12 Aligned_cols=35 Identities=100% Similarity=1.213 Sum_probs=32.0 Template_Neff=3.900 Q sp|P0DTC2|SPIK 1169 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1169 isginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) +..+|++++|++.||++|+++.|+||+|+|||++| T Consensus 2 ~~~~N~t~Lnlt~Ei~~lq~~I~~LN~s~IdLe~L 36 (36) T 6LVN_A 2 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 (36) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC- T ss_pred CcccccccccHHHHHHHHHHHHHHHHhhcCChhhC Confidence 45689999999999999999999999999999875 No 76 >5YL9_B Spike glycoprotein; Spike protein, 6-helical bundle, post-fusion; 1.861A {Human coronavirus 229E} Probab=91.73 E-value=0.063 Score=48.02 Aligned_cols=41 Identities=29% Similarity=0.567 Sum_probs=34.5 Template_Neff=3.600 Q sp|P0DTC2|SPIK 1158 NHTSPDVDLGDISGINASVVNIQKEIDR--------------LNEVAKNLNESLIDLQ 1201 (1273) Q Consensus 1158 nhtspdvdlgdisginasvvniqkeidr--------------lnevaknlneslidlq 1201 (1273) .|+.||.+ +...|+.+.|+..||++ |.++.++||.+++||+ T Consensus 4 ~~t~pdl~---ld~yN~tiLNLt~EI~~Le~rs~~L~~~~~~Lq~~I~nLN~TlVDLE 58 (59) T 5YL9_B 4 RGGVPDLV---VEQYNQTILNLTSEISTLENKSAELNYTVQKLQTLIDNINSTLVDLK 58 (59) T ss_dssp -CCCCCCC---CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCC T ss_pred CCCCCCcc---cccccceecccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccC Confidence 57888884 57789999999999999 7788888888888875 No 77 >5ZUV_A Spike glycoprotein,EK1, Spike glycoprotein,inhibitor EK1; Human Coronavirus 229E, Spike protein; 2.21A {Human coronavirus 229E} Probab=89.53 E-value=0.16 Score=51.20 Aligned_cols=44 Identities=36% Similarity=0.593 Sum_probs=41.1 Template_Neff=2.400 Q sp|P0DTC2|SPIK 1161 SPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1161 spdvdlgdisginasvvniqkeidrlnevaknlneslidlqelg 1204 (1273) ..|+..|....||.....+.-|+.||.++.|+||||.|||.|+| T Consensus 90 eAd~~~gsl~~~n~t~ldl~yem~~~~~~~k~l~~syi~lke~g 133 (133) T 5ZUV_A 90 QSGGRGGSLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELG 133 (133) T ss_dssp SCCCCSCCCCCCCCCCCCCHHHHHHHHHHHHHHTTCCCCHHHHC T ss_pred HhhhccCccccceeeeHHHHHHHHHHHHHHHHHHHhhcchHhhC Confidence 45788899999999999999999999999999999999999987 No 78 >6MAR_D Immunoglobulin G PGT151 Fab, Heavy; Fusion protein-Fab complex, MEMBRANE PROTEIN; HET: NAG, MAN, GAL, FUC, BMA;{Homo sapiens} Probab=71.20 E-value=3 Score=42.93 Aligned_cols=29 Identities=34% Similarity=0.603 Sum_probs=12.5 Template_Neff=7.100 Q sp|P0DTC2|SPIK 1199 DLQELGKYEQYIKW-PWYIWLGFIAGLIAI 1227 (1273) Q Consensus 1199 dlqelgkyeqyikw-pwyiwlgfiagliai 1227 (1273) |+++|.+.+....| +|-.|++.|..++.+ T Consensus 154 ~l~~l~~~~~l~~wf~~~~wl~~iki~i~i 183 (220) T 6MAR_D 154 DLLALDKWASLWNWFDISNWLWYIKIFIMI 183 (220) T ss_pred HHHhhHHHHHHHHhcChHHHHHHHHHHHHH Confidence 44444444444333 334444444433333 No 79 >6DCQ_D Envelope glycoprotein gp160, Immunoglobulin G; HIV-1, Glycoprotein, Env, VIRAL PROTEIN; HET: NAG, GAL, BMA, FUC, MAN;{Human immunodeficiency virus 1} Probab=68.19 E-value=3.9 Score=45.14 Aligned_cols=49 Identities=29% Similarity=0.335 Sum_probs=25.2 Template_Neff=6.700 Q sp|P0DTC2|SPIK 1197 LIDLQELGKYEQYIKW-PWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLK 1245 (1273) Q Consensus 1197 lidlqelgkyeqyikw-pwyiwlgfiagliaivmvtimlccmtsccsclk 1245 (1273) ..|++++.+......| .+..|++.|-.+|.||+..|.|-|+..|.+|.. T Consensus 146 ~~~l~~l~~w~~~~~wf~i~~wl~yiki~i~iv~gli~lri~~~~~~~~~ 195 (352) T 6DCQ_D 146 EKDLLALDKWTNLWNWFGISNWLWYIRIFIMIVGGLIGLRIIFAVLSVIN 195 (352) T ss_pred HHHHHHhHhhhhhHhhhCHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3455555555554333 334455554444555555555655555555543 No 80 >6NIJ_B PGT145 Fab heavy chain, PGT145; HIV-1, antibody, glycoprotein, IMMUNE SYSTEM; HET: NAG, BMA; 5.7A {Homo sapiens} Probab=68.17 E-value=3.9 Score=44.93 Aligned_cols=51 Identities=27% Similarity=0.312 Sum_probs=26.1 Template_Neff=6.800 Q sp|P0DTC2|SPIK 1197 LIDLQELGKYEQYIKW-PWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGC 1247 (1273) Q Consensus 1197 lidlqelgkyeqyikw-pwyiwlgfiagliaivmvtimlccmtsccsclkgc 1247 (1273) ..|++++.+......| .|..|++.|-.++.||+..|.|-|+..|.+|...+ T Consensus 146 ~~~l~~l~~w~~~~~wf~i~~w~~yiki~i~iv~gli~lrii~~~~~~~~~~ 197 (345) T 6NIJ_B 146 EQELLELDKWASLWNWFDITKWLWYIKIFIMIVGGLIGLRIVFTVLSIVNRI 197 (345) T ss_pred HHHHHHHHHhhhHHhhcChhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3455555555554443 34445555544555555556666655555554443 No 81 >1WDF_B E2 glycoprotein; MHV, coronavirus, heptad repeat, fusion; 2.5A {Murine hepatitis virus} SCOP: h.3.3.1 Probab=63.13 E-value=5.7 Score=39.08 Aligned_cols=56 Identities=27% Similarity=0.481 Sum_probs=44.4 Template_Neff=2.400 Q sp|P0DTC2|SPIK 1144 ELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQE 1202 (1273) Q Consensus 1144 eldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqe 1202 (1273) .|......|.+-|..-.|. +.|...||.....+--|+.|+..+.|.||||.|||.| T Consensus 40 AL~~Lt~QL~~NFgAISSs---i~d~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 95 (95) T 1WDF_B 40 ALNNLLNQLSNRFGAISDL---SLDFEKLNVTLLDLTYEMNRIQDAIKKLNESYINLKE 95 (95) T ss_dssp HHHHHHHHHHHHTCC--CC---CCCGGGCCCCCCCCHHHHHHHHHHHHHHHTTCCCTTC T ss_pred HHHHHHHHHHHhHchHHHH---HHHHHHHchHHHHHHHHHHHHHHHHHHHHHHhhcccC Confidence 4555666777777666553 5667788999999999999999999999999999975 No 82 >6GY6_C XaxA, XaxB; bacterial toxin, pore forming-toxins, TOXIN; 4.0A {Xenorhabdus nematophila ATCC 19061} Probab=57.97 E-value=8.2 Score=41.00 Aligned_cols=24 Identities=17% Similarity=0.426 Sum_probs=14.9 Template_Neff=9.300 Q sp|P0DTC2|SPIK 1172 INASVVNIQKEIDRLNEVAKNLNE 1195 (1273) Q Consensus 1172 inasvvniqkeidrlnevaknlne 1195 (1273) +++.+..++++|++|++-.+.++. T Consensus 232 l~~~i~~L~~~I~~l~~~I~~~~~ 255 (424) T 6GY6_C 232 LSTTIKDLQSKIDEKNKEIDQFQK 255 (424) T ss_pred chHHHHHHHHHHHHHHHHHHHHHH Confidence 355666777777777666555443 No 83 >6OJ7_A Fusion glycoprotein F0; Fusion protein, fusion inhibitor, six-helix; 1.45A {N/A} Probab=57.49 E-value=8.5 Score=34.15 Aligned_cols=29 Identities=17% Similarity=0.297 Sum_probs=22.5 Template_Neff=4.500 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 17 TNeAV~~L~~g~~~l~~Av~~iQd~IN~~ 45 (53) T 6OJ7_A 17 TNKAVVSLSNGVSVLTSKVLDLKNYIDKQ 45 (53) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHhhh Confidence 36778888888888888888888877753 No 84 >1G2C_W TWO HEPTAD REPEATS OF HRSV; membrane fusion, pneumovirus, HRSV, Viral; 2.3A {Human respiratory syncytial virus} SCOP: h.3.2.1 Probab=57.47 E-value=8.5 Score=34.10 Aligned_cols=29 Identities=17% Similarity=0.297 Sum_probs=22.4 Template_Neff=4.400 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 17 TNeAV~~L~~g~~~~~~Av~~iQd~IN~~ 45 (52) T 1G2C_W 17 TNKAVVSLSNGVSVLTSKVLDLKNYIDKQ 45 (52) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHCCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHhhh Confidence 46778888888888888888888877753 No 85 >6NYX_H Fusion glycoprotein F0; Fusion protein, fusion inhibitor, six-helix; HET: PEG, PG4; 1.85A {N/A} Probab=57.31 E-value=8.6 Score=34.12 Aligned_cols=29 Identities=31% Similarity=0.434 Sum_probs=23.7 Template_Neff=4.500 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 17 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 45 (53) T 6NYX_H 17 TNKAVQSVQSSIGNLIVAIKSVQDYVNKE 45 (53) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 47788888888888888888888888754 No 86 >6O40_A Fusion glycoprotein F0; Fusion protein, fusion inhibitor, six-helix; 1.2A {N/A} Probab=57.31 E-value=8.6 Score=34.12 Aligned_cols=29 Identities=31% Similarity=0.434 Sum_probs=23.7 Template_Neff=4.500 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 17 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 45 (53) T 6O40_A 17 TNKAVQSVQSSIGNLIVAIKSVQDYVNKE 45 (53) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 47788888888888888888888888754 No 87 >6GY8_A XaxA; bacterial toxin, pore forming-toxins, TOXIN; 2.5A {Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)} Probab=54.96 E-value=10 Score=39.70 Aligned_cols=22 Identities=18% Similarity=0.404 Sum_probs=13.4 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1173 NASVVNIQKEIDRLNEVAKNLN 1194 (1273) Q Consensus 1173 nasvvniqkeidrlnevaknln 1194 (1273) ++.+..++++|++|++-.+.++ T Consensus 233 ~~~i~~L~~~I~~l~~~I~~~~ 254 (408) T 6GY8_A 233 STTIKDLQSKIDEKNKEIDQFQ 254 (408) T ss_dssp HHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHH Confidence 5556666777776666555443 No 88 >6PWU_E Envelope glycoprotein gp160, Antibody PG16; HIV-1, ENV, VIRAL PROTEIN; HET: NAG, MAN, BMA, FUC, GAL;{Human immunodeficiency virus 1} Probab=52.04 E-value=12 Score=46.57 Aligned_cols=53 Identities=26% Similarity=0.308 Sum_probs=30.8 Template_Neff=5.500 Q sp|P0DTC2|SPIK 1196 SLIDLQELGKYEQYIKW-PWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCC 1248 (1273) Q Consensus 1196 slidlqelgkyeqyikw-pwyiwlgfiagliaivmvtimlccmtsccsclkgcc 1248 (1273) ...||++|.+....-.| .|-.|++.|-.+|.|+...|.|-++..|+++...++ T Consensus 651 nek~l~~Ld~w~~l~~Wf~it~Wl~yIKi~i~Iv~gliglrii~~v~~~v~~~r 704 (858) T 6PWU_E 651 NEQELLELDKWANLWNWFDISNWLWYIKIFIMIVGGLIGLRIVFAVLSVINRVR 704 (858) T ss_pred HHHHHHchHHHHHHHHhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 34566667666665444 344566666666666666666666666666554443 No 89 >3EUH_B Chromosome partition protein mukF, MukE; Chromosome condensation, condensin, non-SMC subunit; HET: GLY; 2.9A {Escherichia coli} Probab=52.03 E-value=12 Score=44.15 Aligned_cols=126 Identities=22% Similarity=0.336 Sum_probs=81.9 Template_Neff=3.500 Q sp|P0DTC2|SPIK 858 LTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLI--------ANQFNS 929 (1273) Q Consensus 858 ltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqkli--------anqfns 929 (1273) |+++-..+.+|+-.-..+| ..|.-...|--..-+-|.+ -.+--|.||-.+|.++-|.|..+ ...+.+ T Consensus 125 LS~~l~~va~eL~~a~~aA-~e~~~e~~W~~~V~apLky----SV~ei~d~Id~~QR~mDeqq~~vk~eIa~LL~qDW~~ 199 (440) T 3EUH_B 125 LSMQLSIVAGELKRAADAA-EEGGDEFHWHRNVYAPLKY----SVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRA 199 (440) T ss_dssp HHHHHHHHHHHHHHHHHHH-HTCCCHHHHCCCCCHCCCC----CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHGGG T ss_pred HHHHHHHHHHHHHHHHHHH-HhcCCHHHHHhhccccccc----cHHHHHHhcchhHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3344444455554444444 3333455676665555544 44567899999999999988543 345667 Q sp|P0DTC2|SPIK 930 AIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSS------NFGAISSVLNDILSRLDKVE 988 (1273) Q Consensus 930 aigkiqdslsstasalgklqdvvnqnaqalntlvkqlss------nfgaissvlndilsrldkve 988 (1273) ||..-+.-|+.|++.|..|||.+......|.++...+.+ ....+..++-++..+||.+. T Consensus 200 AI~~Ce~LL~eTs~tLrELqdtL~aagd~lq~~Ll~IQ~~~~~~~~l~~v~~~~~~Lq~kLDrI~ 264 (440) T 3EUH_B 200 AISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRII 264 (440) T ss_dssp GHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCSCGGGHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCcchHHHHHHHHHHHHHHHHHH Confidence 888999999999999999999999888777766655432 22224445555555555544 No 90 >3MAW_A Fusion glycoprotein F0; Fusion protein, class I, paramyxovirus; HET: NAG, NDG; 3.5A {Newcastle disease virus} Probab=50.68 E-value=13 Score=43.97 Aligned_cols=76 Identities=29% Similarity=0.351 Sum_probs=26.5 Template_Neff=4.900 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.++++ .-|.-...=|.|+.++++.++.++.|+.++||-+|. T Consensus 83 ~~Rf~G~iig~~ALGVAtaaqiTA~vAl~~a~~---na~~I~--~lk~si~~TN~AV~~l~~~~~~~~~Av~~lQd~IN~ 157 (483) T 3MAW_A 83 QGRFIGAIIGSVALGVATAAQITAASALIQANQ---NAANIL--RLKESITATNEAVHEVTDGLSQLAVAVGKMQQFVND 157 (483) T ss_dssp -------------------------------CC---THHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cceeeeehHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345678888888888888888876544321100 001111 011112345778888888888888888888888875 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 158 ~ 158 (483) T 3MAW_A 158 Q 158 (483) T ss_dssp H T ss_pred h Confidence 4 No 91 >6EK7_A YaxA; pathogens, pore forming toxins, alpha-helical; HET: MPD; 1.8A {Yersinia enterocolitica} Probab=49.86 E-value=14 Score=39.26 Aligned_cols=23 Identities=13% Similarity=0.316 Sum_probs=12.9 Template_Neff=9.300 Q sp|P0DTC2|SPIK 1172 INASVVNIQKEIDRLNEVAKNLN 1194 (1273) Q Consensus 1172 inasvvniqkeidrlnevaknln 1194 (1273) .+..+..++++|++|++-.+.++ T Consensus 234 ~~~~i~~L~~~I~~l~~~I~~~~ 256 (410) T 6EK7_A 234 MRKSIKELDEKIKEKRQRIEQLK 256 (410) T ss_dssp CHHHHHHHHHHHHHHHHHHHHTH T ss_pred chHHHHHHHHHHHHHHHHHHHHH Confidence 34455666666666665544443 No 92 >1SVF_C SV5 FUSION PROTEIN; PARAMYXOVIRUS, FUSION, SV5, COILED-COIL, Viral; 1.4A {Simian virus 5 (strain W3)} SCOP: h.3.2.1 Probab=49.38 E-value=14 Score=34.05 Aligned_cols=29 Identities=24% Similarity=0.340 Sum_probs=21.7 Template_Neff=4.200 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++.|+.++||.+|.+ T Consensus 26 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 54 (64) T 1SVF_C 26 TNAAVADVVQATQSLGTAVQAVQDHINSV 54 (64) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 46677777888888888888888877653 No 93 >1SVF_A SV5 FUSION PROTEIN; PARAMYXOVIRUS, FUSION, SV5, COILED-COIL, Viral; 1.4A {Simian virus 5 (strain W3)} SCOP: h.3.2.1 Probab=49.38 E-value=14 Score=34.05 Aligned_cols=29 Identities=24% Similarity=0.340 Sum_probs=21.7 Template_Neff=4.200 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++.|+.++||.+|.+ T Consensus 26 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 54 (64) T 1SVF_A 26 TNAAVADVVQATQSLGTAVQAVQDHINSV 54 (64) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 46677777888888888888888877653 No 94 >2FYZ_E Fusion glycoprotein F0; Mumps virus fusion protein core; 2.2A {Mumps virus} Probab=48.54 E-value=15 Score=33.83 Aligned_cols=29 Identities=24% Similarity=0.274 Sum_probs=22.0 Template_Neff=4.200 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 29 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 57 (63) T 2FYZ_E 29 TNRAVFEVKEGTQRLAIAVQAIQDHINTI 57 (63) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHTTT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 46777788888888888888888877753 No 95 >2B9B_B Parainfluenza Virus 5 F Protein; fusion protein, pre-fusion conformation, VIRAL; HET: NAG; 2.85A {Simian virus 5} Probab=48.31 E-value=15 Score=43.73 Aligned_cols=76 Identities=21% Similarity=0.253 Sum_probs=40.5 Template_Neff=4.600 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.++++ .-|.-...=|.|+.++++.++.++-|+.++||-+|. T Consensus 79 ~~Rf~G~iig~~ALGVATaAqiTA~vAL~~a~~---na~~I~--~lk~si~~TN~AV~~l~~~~~~~~~Av~~iQd~IN~ 153 (497) T 2B9B_B 79 RRRFAGVVIGLAALGVATAAQVTAAVALVKANE---NAAAIL--NLKNAIQKTNAAVADVVQATQSLGTAVQAVQDHINS 153 (497) T ss_dssp --CCCSCCCCGGGGCEEEHHHHHHHHHHHHHHH---HHHHHT--TSHHHHHHSCCSECEEE--------EECSSHHHHHH T ss_pred chhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 445788888888999998888876554321100 001110 001112245778888899999999999999988875 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 154 ~ 154 (497) T 2B9B_B 154 V 154 (497) T ss_dssp H T ss_pred c Confidence 4 No 96 >5YZC_B glycoprotein F2, glycoprotein F1,measles virus; glycoprotein, viral protein, fusion protein; HET: NAG, 95C; 2.334A {Measles virus (strain Ichinose-B95a)} Probab=47.22 E-value=16 Score=42.71 Aligned_cols=73 Identities=23% Similarity=0.281 Sum_probs=47.9 Template_Neff=4.700 Q sp|P0DTC2|SPIK 878 LAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 878 lagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqn 955 (1273) ++|.|..+..+|.+.|.||--|..+.--- --.++++ .-|.-...=|.|+.++++.++.++.|+.++||-+|.+ T Consensus 1 ~~g~~ig~~algvataaqita~~al~~a~---~na~~i~--~lk~si~~tn~AV~~L~~g~~~~~~AV~~lQd~IN~~ 73 (419) T 5YZC_B 1 FAGVVLAGAALGVATAAQITAGIALHQSM---LNSQAID--NLRASLETTNQAIEAIRQAGQEMILAVQGVQDYINNE 73 (419) T ss_dssp --CEEECHHHHCCCCHHHHHHHHHHHHHS---CCHHHHH--HHHHHHHTCCCSEEEECCTTSCCEEEEETTHHHCCCC T ss_pred ChhHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 46778888889988888887655432110 0011111 1111223458899999999999999999999999854 No 97 >1T98_B Chromosome partition protein mukF; WINGED HELIX, HELIX-TURN HELIX, DOMAIN; HET: MSE; 2.9A {Escherichia coli} SCOP: a.47.6.1, a.4.5.65 Probab=46.81 E-value=16 Score=41.26 Aligned_cols=104 Identities=23% Similarity=0.322 Sum_probs=67.4 Template_Neff=3.500 Q sp|P0DTC2|SPIK 858 LTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIAN--------QFNS 929 (1273) Q Consensus 858 ltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklian--------qfns 929 (1273) |+++-..+.+|+-.-..+|. .|.=-..|--..-|-|.+ -.+--|.||..+|-++-|.|..+.+ .+.+ T Consensus 125 LS~ql~~va~eL~~a~~AA~-e~gde~~W~~~V~apLky----SV~eifd~Id~~QR~mDeqQ~~vk~eIA~LL~~DW~~ 199 (287) T 1T98_B 125 LSMQLSIVAGELKRAADAAE-EGGDEFHWHRNVYAPLKY----SVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRA 199 (287) T ss_dssp HHHHHHHHHHHHHHHHHHHH-SCCSHHHHCCCCCHCCCC----CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHTC----- T ss_pred HHHHHHHHHHHHHHHHHHHH-hcCCHHHHHhhccccccc----cHHHHHHhcchHHHHHHHHHHHHHHHHHHHHCccHHH Confidence 34444445555444434443 333345676665555544 3456789999999999999865443 3457 Q sp|P0DTC2|SPIK 930 AIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQL 966 (1273) Q Consensus 930 aigkiqdslsstasalgklqdvvnqnaqalntlvkql 966 (1273) ||..-+.-|+.|++.|..|||........|.++...+ T Consensus 200 AI~~Ce~LL~eTs~tLrELqdtL~aagd~lq~~Ll~I 236 (287) T 1T98_B 200 AISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRI 236 (287) T ss_dssp -CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 8888899999999999999999887776666554443 No 98 >1T98_A Chromosome partition protein mukF; WINGED HELIX, HELIX-TURN HELIX, DOMAIN; 2.9A {Escherichia coli} SCOP: a.47.6.1, a.4.5.65 Probab=46.81 E-value=16 Score=41.26 Aligned_cols=104 Identities=23% Similarity=0.322 Sum_probs=70.3 Template_Neff=3.500 Q sp|P0DTC2|SPIK 858 LTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIAN--------QFNS 929 (1273) Q Consensus 858 ltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklian--------qfns 929 (1273) |+++-..+.+|+-.-..+|. .|.=-..|--..-|-|.+ -.+--|.||..+|-++-|.|..+.+ .+.+ T Consensus 125 LS~ql~~va~eL~~a~~AA~-e~gde~~W~~~V~apLky----SV~eifd~Id~~QR~mDeqQ~~vk~eIA~LL~~DW~~ 199 (287) T 1T98_A 125 LSMQLSIVAGELKRAADAAE-EGGDEFHWHRNVYAPLKY----SVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRA 199 (287) T ss_pred HHHHHHHHHHHHHHHHHHHH-hCCCHHHHHhhccccccc----cHHHHHHhcchhHHHHHHHHHHHHHHHHHHHcccHHH Confidence 34444445555444434443 333345676665555544 3456789999999999999865443 3457 Q sp|P0DTC2|SPIK 930 AIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQL 966 (1273) Q Consensus 930 aigkiqdslsstasalgklqdvvnqnaqalntlvkql 966 (1273) ||..-+.-|+.|++.|..|||........|.++...+ T Consensus 200 AI~~Ce~LL~eTs~tLrELqdtL~aagd~lq~~Ll~I 236 (287) T 1T98_A 200 AISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRI 236 (287) T ss_pred HHHHHHHHHHHHhhHHHHHHHHHHHhHHHHHHHHHHH Confidence 8888899999999999999999887776666554443 No 99 >1G5G_F FUSION PROTEIN; fusion protein, NDV, Newcastle disease; HET: BMA, NAG; 3.3A {Newcastle disease virus} SCOP: f.12.1.1, h.3.2.1 Probab=45.56 E-value=18 Score=42.92 Aligned_cols=76 Identities=30% Similarity=0.372 Sum_probs=15.9 Template_Neff=4.900 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.++++ .-|.-...=|.|+.++++.++.++-|+.++||-+|. T Consensus 83 ~~Rf~G~iig~~ALGVAtaAqiTA~vAl~~a~~---na~~I~--~lk~si~~TN~AV~~l~~~~~~~~~Av~~iQd~IN~ 157 (481) T 1G5G_F 83 QGRLIGAIIGGVALGVATAAQITAASALIQANQ---NAANIL--RLKESIAATNEAVHEVTNGLSQLAVAVGKMQQFVND 157 (481) T ss_dssp --------------------------------------------------------------CHHHHHHHHHHHHHHHHH T ss_pred cceehhhHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345678888888889888888876544321100 001110 011112234778888888888888888888888875 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 158 ~ 158 (481) T 1G5G_F 158 Q 158 (481) T ss_dssp H T ss_pred h Confidence 4 No 100 >5EVM_F Fusion glycoprotein F0; fusion protein, Nipah, prefusion, paramyxovirus; HET: MAN, NAG, MLI, BMA; 3.367A {Nipah virus} Probab=45.38 E-value=18 Score=43.38 Aligned_cols=76 Identities=29% Similarity=0.344 Sum_probs=44.9 Template_Neff=4.700 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.+++. .-|.-...=|.|+.++++.++.++.|+.++||-+|. T Consensus 107 ~~RF~G~vig~vaLGVATaAqiTA~vAL~~a~~---na~~I~--~lk~si~~TN~AV~~l~~~~~~~~~Avq~iQd~IN~ 181 (529) T 5EVM_F 107 DVRLAGVIMAGVAIGIATAAQITAGVALYEAMK---NADNIN--KLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINT 181 (529) T ss_dssp ------EEEEHHHHCSEEHHHHHHHHHHHHHHH---HHHHHH--TTHHHHHHCCSSEEECCCSSSSCCEEEETTHHHCCC T ss_pred ChhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345678888888899888888876554432110 001110 011112345788888888999999999999988876 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 182 ~ 182 (529) T 5EVM_F 182 N 182 (529) T ss_dssp C T ss_pred c Confidence 4 No 101 >6T3F_F Fusion glycoprotein F0, Fab66 light; Fusion Protein, Glycoprotein, Antibody, Fab; HET: NAG; 3.2A {Nipah virus} Probab=42.88 E-value=21 Score=42.66 Aligned_cols=76 Identities=29% Similarity=0.344 Sum_probs=49.9 Template_Neff=4.700 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.+++. .-|.-...=|.|+.++++.++.++.|+.++||-+|. T Consensus 85 ~~Rf~G~iig~~ALGVAtaAqiTAgvAL~~a~~---na~~I~--~lk~si~~TN~AV~~l~~g~~~~~~Avq~iQd~IN~ 159 (502) T 6T3F_F 85 DVRLAGVIMAGVAIGIATAAQITAGVALYEAMK---NADNIN--KLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINT 159 (502) T ss_dssp CSSCCSCEECHHHHCSCCHHHHHHHHHHHHHHH---HHHHHH--TTHHHHHHCCSSEEEECSSSSSCEEEEETTHHHCCC T ss_pred ChhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 445678888888888888888876544321100 011111 011112345889999999999999999999999886 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 160 ~ 160 (502) T 6T3F_F 160 N 160 (502) T ss_dssp C T ss_pred c Confidence 4 No 102 >3N27_B Fusion glycoprotein F0, linker, Fusion; Fusion protein, Chimera protein, fusion; HET: CIT, TBU; 1.8A {Hendravirus, Nipahvirus} Probab=42.74 E-value=21 Score=34.63 Aligned_cols=28 Identities=32% Similarity=0.335 Sum_probs=18.2 Template_Neff=2.800 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnq 954 (1273) -|.|+.+++++++.++-|+.++||.+|. T Consensus 18 TNeAV~eL~~gl~q~avAIqaIQd~IN~ 45 (80) T 3N27_B 18 TNEAVVKLQETAEKTVYVLTALQDYSGG 45 (80) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHSSS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhcC Confidence 3556666666666666666666666654 No 103 >1ZTM_C Fusion glycoprotein; fusion protein, 6-helix bundle,trimer, post-fusion; HET: NAG; 3.05A {Human parainfluenza virus 3} Probab=42.53 E-value=21 Score=42.44 Aligned_cols=75 Identities=20% Similarity=0.251 Sum_probs=29.7 Template_Neff=4.800 Q sp|P0DTC2|SPIK 876 ALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 876 allagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqn 955 (1273) .-++|.|..|-.+|.+.|.||--|..+.-.- --.++++ .-|.-...=|.|+.++++.++.++.|+.++||-+|.+ T Consensus 90 ~r~~g~iig~~algvataaqita~~al~~a~---~na~~i~--~lk~si~~tn~AV~~L~~g~~~~~~Avq~iQd~IN~~ 164 (490) T 1ZTM_C 90 KRFFGGVIGTIALGVATSAQITAAVALVEAK---QARSDIE--KLKEAIRDTNKAVQSVQSSIGNLIVAIKSVQDYVNKE 164 (490) T ss_dssp ----------------------------CCC---CCCSHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC T ss_pred ccchhHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhc Confidence 3467778888888888888887654432110 0011111 1122223458899999999999999999999998864 No 104 >4GIP_D Fusion glycoprotein F2, Fusion glycoprotein; PIV5, viral fusion protein, membrane; HET: NAG; 2.0A {Simian virus 5} Probab=42.00 E-value=22 Score=41.54 Aligned_cols=72 Identities=22% Similarity=0.278 Sum_probs=47.3 Template_Neff=4.800 Q sp|P0DTC2|SPIK 878 LAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVL-YENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 878 lagtitsgwtfgagaalqipfamqmayrfngigvtqnvl-yenqklianqfnsaigkiqdslsstasalgklqdvvnqn 955 (1273) ++|.+..|..+|.+.|.||--|..+.- ..||.- ...-|.-...=|.|+.++++.++.++.|+.++||-+|.+ T Consensus 1 ~~g~~ig~~algvataaqita~~al~~------a~~na~~i~~lk~si~~tn~AV~~L~~g~~~~~~Av~~lQd~IN~~ 73 (409) T 4GIP_D 1 FAGVVIGLAALGVATAAQVTAAVALVK------ANENAAAILNLKNAIQKTNAAVADVVQATQSLGTAVQAVQDHINSV 73 (409) T ss_dssp CCSCEECGGGGCEEEHHHHHHHHHHHH------THHHHHHHHTTHHHHHHCCCSEEEEEETTEEEEEEECTTHHHHHHH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHc Confidence 467888888899888888876554321 111110 000111223457889999999999999999999988754 No 105 >6H2E_Q AhlB; Tripartite pore-forming toxin, TOXIN; 2.35A {Aeromonas hydrophila} Probab=41.72 E-value=22 Score=35.49 Aligned_cols=23 Identities=22% Similarity=0.426 Sum_probs=11.9 Template_Neff=9.500 Q sp|P0DTC2|SPIK 1173 NASVVNIQKEIDRLNEVAKNLNE 1195 (1273) Q Consensus 1173 nasvvniqkeidrlnevaknlne 1195 (1273) +..+..++++|++|++-.+.++. T Consensus 128 ~~~i~~l~~~I~~l~~~i~~~~~ 150 (274) T 6H2E_Q 128 QATIAGLQSNLDGARQELDSLNK 150 (274) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHH Confidence 34445555556555555544444 No 106 >5IJO_G Nuclear pore complex protein Nup155; Nuclear pore complex, Nucleocytoplasmic transport; 21.4A {Homo sapiens} Probab=40.35 E-value=24 Score=42.67 Aligned_cols=55 Identities=18% Similarity=0.345 Sum_probs=33.8 Template_Neff=5.300 Q sp|P0DTC2|SPIK 1133 VNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEV 1189 (1273) Q Consensus 1133 vnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnev 1189 (1273) ..++-|+.|.+|+....|+||||+|....-.-++...+. ..+.+|+++|++|... T Consensus 239 sk~~K~~dLP~eIqk~VE~LdkfIK~QkqisdEIsr~Ss--~~l~kV~~DIe~L~q~ 293 (599) T 5IJO_G 239 SKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSS--KAMLKVQEDIKALKQL 293 (599) T ss_dssp ---------CHHHHHHHHHHHHHHHHHHHHHHHHHHHCC--SHHHHHHHHHHHHHHH T ss_pred chhhhhccCCHHHHHHHHHHHHHHHHHHHHHHHHHhcCH--HHHHHHHHHHHHHHHH Confidence 346778888889988899999999988776666665553 3466777777766543 No 107 >1WP7_A fusion protein; Nipah Virus, Fusion Core, heptad; 2.2A {Nipah virus} Probab=40.33 E-value=24 Score=34.77 Aligned_cols=28 Identities=32% Similarity=0.322 Sum_probs=18.7 Template_Neff=2.700 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnq 954 (1273) -|.|+.+++++++.++-|+.++||-+|. T Consensus 18 TNeAV~eL~~gl~qtavAIqaIQD~IN~ 45 (89) T 1WP7_A 18 TNEAVVKLQETAEKTVYVLTALQDYGGS 45 (89) T ss_dssp HHHHHHHHHHHHHHHHHHHHHCCC---- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHccC Confidence 4677777888888888888888877763 No 108 >1WP8_C fusion; Hendra Virus, Fusion Core, heptad; 2.2A {Hendra virus} Probab=39.60 E-value=25 Score=34.65 Aligned_cols=28 Identities=32% Similarity=0.322 Sum_probs=18.4 Template_Neff=2.700 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnq 954 (1273) -|.|+.+++++++.++-|+.++||-+|. T Consensus 18 TNeAV~eL~~gl~qtavAIqaIQD~IN~ 45 (89) T 1WP8_C 18 TNEAVVKLQETAEKTVYVLTALQDYGGS 45 (89) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHTC---- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHccC Confidence 4667777777777777777777777763 No 109 >6R1J_J AhlB; Tripartite pore-forming toxin, TOXIN; 1.92A {Aeromonas hydrophila J-1} Probab=39.16 E-value=26 Score=34.77 Aligned_cols=24 Identities=21% Similarity=0.447 Sum_probs=12.5 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1172 INASVVNIQKEIDRLNEVAKNLNE 1195 (1273) Q Consensus 1172 inasvvniqkeidrlnevaknlne 1195 (1273) ++..+..++++|+.|++-.+.++. T Consensus 127 ~~~~i~~l~~~I~~l~~~I~~~~~ 150 (272) T 6R1J_J 127 LQATIAGLQSNLDGARQELDSLNK 150 (272) T ss_pred chHhHHHHHHHHHHHHHHHHHHHH Confidence 344445555566655555554444 No 110 >6C14_A Protocadherin-15, LHFPL tetraspan subfamily member; PCDH15, LHFPL5, protocadherin, tip link;{Mus musculus} Probab=38.64 E-value=27 Score=35.39 Aligned_cols=26 Identities=35% Similarity=0.680 Sum_probs=13.7 Template_Neff=10.000 Q sp|P0DTC2|SPIK 1108 NFYEPQIITTDNT--FVSGNCDVVIGIV 1133 (1273) Q Consensus 1108 nfyepqiittdnt--fvsgncdvvigiv 1133 (1273) ..|+-.+..+|+. -.+..+.|.|-++ T Consensus 82 ~~~~l~V~A~D~~~~~~~~~~~v~I~V~ 109 (337) T 6C14_A 82 SYFKFQVIATDDYGKGLSGKADVLVSVV 109 (337) T ss_dssp CCEEEEEEEEHHHHTSCEEEEEEEECEE T ss_pred CeEEEEEEEEcCCCCCCCeEEEEEEEEe Confidence 4556666667764 2334455555443 No 111 >5EJB_D Fusion glycoprotein F0; prefusion form, viral glycoprotein, ectodomain; HET: NAG, SO4; 3.2A {Hendra virus} Probab=38.02 E-value=28 Score=41.68 Aligned_cols=76 Identities=28% Similarity=0.344 Sum_probs=45.1 Template_Neff=4.700 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|..+|.+.|.||--|..+.--.. -.+++. .-|.-...=|.|+.++++.++.++.|+.++||-+|. T Consensus 82 ~~Rf~G~iig~~AlgVAtaaqita~vAl~~a~~---na~~i~--~lk~si~~tn~AV~~L~~g~~~~~~Avq~lQd~IN~ 156 (501) T 5EJB_D 82 DVKLAGVVMAGIAIGIATAAQITAGVALYEAMK---NADNIN--KLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINT 156 (501) T ss_dssp -------CEEHHHHCSEEHHHHHHHHHHHHHHH---HHHHHH--TTHHHHHTCCSSEEEEECSSSCEEEEEETTHHHCCC T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345678888888888888888765543321100 001111 011112345889999999999999999999999886 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 157 ~ 157 (501) T 5EJB_D 157 N 157 (501) T ss_dssp C T ss_pred c Confidence 4 No 112 >2M8R_A Syntaxin-1A; syntaxin, SNARE, Prefusion, membrane protein; NMR {Rattus norvegicus} Probab=36.65 E-value=30 Score=29.72 Aligned_cols=12 Identities=8% Similarity=0.033 Sum_probs=5.6 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1211 KWPWYIWLGFIA 1222 (1273) Q Consensus 1211 kwpwyiwlgfia 1222 (1273) +|-|++.+++++ T Consensus 84 ~~~~~~~~~~~~ 95 (109) T 2M8R_A 84 RKKIMIIICCVI 95 (109) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 355555444333 No 113 >3HD7_B Vesicle-associated membrane protein 2, Syntaxin-1A; MEMBRANE PROTEIN, COILED-COIL, 4-HELICAL BUNDLE; HET: SO4, GGG; 3.4A {Rattus norvegicus} Probab=36.65 E-value=30 Score=29.72 Aligned_cols=12 Identities=8% Similarity=0.033 Sum_probs=5.6 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1211 KWPWYIWLGFIA 1222 (1273) Q Consensus 1211 kwpwyiwlgfia 1222 (1273) +|-|++.+++++ T Consensus 84 ~~~~~~~~~~~~ 95 (109) T 3HD7_B 84 RKKIMIIICCVI 95 (109) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 355555444333 No 114 >5C3L_B Nucleoporin Nup54, MGC84997 protein, Nucleoporin; nucleoporin, heterotrimeric coiled coils, kink; 2.9A {Xenopus laevis} Probab=34.34 E-value=35 Score=32.07 Aligned_cols=57 Identities=16% Similarity=0.251 Sum_probs=31.9 Template_Neff=8.500 Q sp|P0DTC2|SPIK 1131 GIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEV 1189 (1273) Q Consensus 1131 givnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnev 1189 (1273) ++--+|-|+.|.|++....++|+++++....-.-++...+- ..+..+..++++|..- T Consensus 6 ~~~~~tkf~dLp~~~q~~l~~ld~~I~~q~~~~~el~~~~~--~~~~~i~~di~~l~~~ 62 (142) T 5C3L_B 6 EDSKALKDENLPQLLCQDVENFQKFVKEQKQVQEEISRMSS--KAMLKVQEDIKALKQL 62 (142) T ss_dssp ------------CCSGGGGGGGTHHHHHHHHHHHHHHHCCS--HHHHHHHHHHHHHHHH T ss_pred ccccccccccCCHHHHHHHHHHHHHHHHHHHHHHHHHhhch--HHHHHHHHHHHHHHHH Confidence 34557889999999999999999999987766655555443 3566666666655443 No 115 >5G6U_A LANGERIN; CARBOHYDRATE BINDING PROTEIN, LANGERIN, CD207; HET: TRP, CL, YJM; 1.844A {HOMO SAPIENS} Probab=32.97 E-value=38 Score=33.48 Aligned_cols=42 Identities=17% Similarity=0.467 Sum_probs=25.7 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1038 KRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFP 1090 (1273) Q Consensus 1038 krvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdgkahfp 1090 (1273) .....|..||.... |..| |+....++|..|-..|.+-.+|.. T Consensus 123 ~~~~~c~~~w~~~~-------~~cy----~~~~~~~tw~~A~~~C~~~g~~L~ 164 (261) T 5G6U_A 123 DILQVVSQGWKYFK-------GNFY----YFSLIPKTWYSAEQFCVSRNSHLT 164 (261) T ss_pred cccccCCCCeEEEC-------CEEE----EEEeceeCHHHHHHHHHHcCCEee Confidence 44567877776531 2211 222346788899999988766654 No 116 >3IPD_E Vesicle-associated membrane protein 2, Syntaxin-1A; MEMBRANE PROTEIN, COILED COIL, 4-HELICAL; 4.8A {Rattus norvegicus} Probab=26.85 E-value=56 Score=28.69 Aligned_cols=9 Identities=33% Similarity=0.386 Sum_probs=3.8 Template_Neff=8.400 Q sp|P0DTC2|SPIK 1212 WPWYIWLGF 1220 (1273) Q Consensus 1212 wpwyiwlgf 1220 (1273) +-|++.+++ T Consensus 68 ~k~~iii~~ 76 (91) T 3IPD_E 68 LKMMIILGV 76 (91) T ss_dssp HHHHHTTTT T ss_pred HHHHHHHHH Confidence 344444443 No 117 >3HD7_A Vesicle-associated membrane protein 2, Syntaxin-1A; MEMBRANE PROTEIN, COILED-COIL, 4-HELICAL BUNDLE; HET: SO4, GGG; 3.4A {Rattus norvegicus} Probab=26.85 E-value=56 Score=28.69 Aligned_cols=9 Identities=33% Similarity=0.386 Sum_probs=3.8 Template_Neff=8.400 Q sp|P0DTC2|SPIK 1212 WPWYIWLGF 1220 (1273) Q Consensus 1212 wpwyiwlgf 1220 (1273) +-|++.+++ T Consensus 68 ~k~~iii~~ 76 (91) T 3HD7_A 68 LKMMIILGV 76 (91) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 344444443 No 118 >6BP2_B Envelope Glycoprotein GP1, Envelope Glycoprotein; Marburg, Ravn, Glycoprotein, Complex, VIRAL; HET: NAG, BMA, MAN; 3.172A {Marburg marburgvirus} Probab=24.89 E-value=64 Score=35.25 Aligned_cols=40 Identities=13% Similarity=0.088 Sum_probs=26.5 Template_Neff=4.200 Q sp|P0DTC2|SPIK 925 NQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 925 nqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) .+....+....++++.....+..+..+|-||..||.-|.- T Consensus 122 ~~l~k~~N~Ts~ALs~L~~ql~SLr~vvLQNR~ALD~LLa 161 (202) T 6BP2_B 122 CRLRRLANQTAKSLELLLRVTTEERTFSLINRHAIDFLLT 161 (202) T ss_dssp HHHHHHHHHHHHHHHHHHHHCCCCSCCCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhhchhHHhHHHH Confidence 3334444445555556666666678899999999987654 No 119 >6QD8_D Light chain, Virion spike glycoprotein,EBOV-GP1; Antibody, immune response, viral infection; HET: NAG, BMA;{Homo sapiens} Probab=23.45 E-value=72 Score=33.90 Aligned_cols=34 Identities=18% Similarity=0.191 Sum_probs=21.5 Template_Neff=4.700 Q sp|P0DTC2|SPIK 931 IGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 931 igkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) +....++++.....+..+..+|-||..||.-|.- T Consensus 61 ~N~T~~aL~~L~~ql~Slr~vvLQNR~ALD~Ll~ 94 (168) T 6QD8_D 61 ANETTQALQLFLRATTELRTFSILNRKAIDFLLQ 94 (168) T ss_dssp HHHHHHHHHHHHHHCCCSEECCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHhhchhHHHHHHH Confidence 3334444444445555567788999999887643 No 120 >4NJL_A S protein; six-helix-bundle, coronavirus, MERS-Cov, fusion inhibitor; HET: PGE; 2.3A {Middle East respiratory syndrome coronavirus} Probab=22.64 E-value=76 Score=33.23 Aligned_cols=27 Identities=52% Similarity=0.736 Sum_probs=14.8 Template_Neff=2.500 Q sp|P0DTC2|SPIK 1178 NIQKEIDRLNEVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1178 niqkeidrlnevaknlneslidlqelg 1204 (1273) .+--|.-.+..+.|.+||+.|||.||| T Consensus 104 d~t~~~~s~~q~~~~~ne~~~~~~~~~ 130 (131) T 4NJL_A 104 DLTYEMLSLQQVVKALNESYIDLKELG 130 (131) T ss_dssp CCHHHHHHHHHHHHHHHTTCCCGGGSC T ss_pred HHHHHHhhHHHHHHHHHHhcccHHHhc Confidence 333333444555566666666666665 No 121 >4LWS_B Uncharacterized protein; ESX Secretion, Signal Sequence, Type; HET: ACT, GOL; 2.0A {Thermomonospora curvata} Probab=22.18 E-value=79 Score=26.31 Aligned_cols=32 Identities=9% Similarity=0.094 Sum_probs=19.5 Template_Neff=10.300 Q sp|P0DTC2|SPIK 955 NAQALNTLVKQLSSNFGAISSVLNDILSRLDK 986 (1273) Q Consensus 955 naqalntlvkqlssnfgaissvlndilsrldk 986 (1273) .++++..+.+++...+..+...|+++-..|.. T Consensus 54 a~~~~~~~~~~~~~~~~~~~~~l~~~~~~l~~ 85 (103) T 4LWS_B 54 AQAAYWNYQKEWDAAAKDMQNVVAQLGVAIRE 85 (103) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 45556666666666666666666666555544 No 122 >2NRJ_A Hbl B protein; Enterotoxin Hemolysis Transmembrane; 2.03A {Bacillus cereus} SCOP: h.4.4.2 Probab=21.90 E-value=80 Score=32.38 Aligned_cols=15 Identities=20% Similarity=0.202 Sum_probs=6.3 Template_Neff=9.900 Q sp|P0DTC2|SPIK 1205 KYEQYIKWPWYIWLG 1219 (1273) Q Consensus 1205 kyeqyikwpwyiwlg 1219 (1273) +|+.++..-|++++| T Consensus 194 ~~~~~~~~~~~~~~g 208 (346) T 2NRJ_A 194 YYKQLESDGFNVMKG 208 (346) T ss_dssp GGGCCC--CCGGGTS T ss_pred HHHHHhhccchhchH Confidence 455554444544444 No 123 >2N2A_B Receptor tyrosine-protein kinase erbB-2; HER2, ErbB2, Tyrosine kinase, Activation; NMR {Homo sapiens} Probab=21.75 E-value=81 Score=26.93 Aligned_cols=23 Identities=22% Similarity=0.033 Sum_probs=13.7 Template_Neff=7.000 Q sp|P0DTC2|SPIK 1206 YEQYIKWPWYIWLGFIAGLIAIV 1228 (1273) Q Consensus 1206 yeqyikwpwyiwlgfiagliaiv 1228 (1273) |||-.+-...|+.|.++|+++++ T Consensus 1 ~~~~~~~~~~I~~~Vvg~l~~~~ 23 (58) T 2N2A_B 1 AEQRASPLTSIISAVVGILLVVV 23 (58) T ss_dssp CCCCCCHHHHHHHHHHHHHHHHH T ss_pred CCcccCChHHHHHHHHHHHHHHH Confidence 34555545557777777776443 No 124 >6F5U_B Envelope glycoprotein,GP1, Envelope glycoprotein; EBOLA VIRUS, FILOVIRIDAE, ENVELOPE GLYCOPROTEIN; HET: NAG, GOL, CQN, DMS, BMA, MAN; 2.07A {Zaire ebolavirus (strain Mayinga-76)} Probab=21.41 E-value=83 Score=33.10 Aligned_cols=38 Identities=16% Similarity=0.183 Sum_probs=24.4 Template_Neff=5.300 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) ....+....++++.....+..+..+|-||..||.-|.- T Consensus 57 l~~~~n~T~~al~~L~~~l~slr~vvLQNR~aLD~Ll~ 94 (168) T 6F5U_B 57 LRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQ 94 (168) T ss_dssp HHHHHHHHHHHHHHHHHHCCCSEECCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHhhchhHHHHHHH Confidence 33334444555555555556677889999999887653 No 125 >5F1B_B GP1, GP2, Niemann-Pick C1 protein; Ebola virus, glycoprotein, NPC1-C, VIRAL; HET: NAG; 2.3A {Zaire ebolavirus} Probab=21.40 E-value=84 Score=31.95 Aligned_cols=37 Identities=16% Similarity=0.180 Sum_probs=24.1 Template_Neff=5.300 Q sp|P0DTC2|SPIK 929 SAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQ 965 (1273) Q Consensus 929 saigkiqdslsstasalgklqdvvnqnaqalntlvkq 965 (1273) ..+....++++.....+..+..+|-||..||.-|.-+ T Consensus 52 ~~~n~t~~al~~L~~~l~sl~~vvLQNR~aLD~Ll~~ 88 (130) T 5F1B_B 52 QLANETTQALQLFLRATTELRTFSILNRKAIDFLLQR 88 (130) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHhhhHHHHHHHHHh Confidence 3344445555555555666778889999998876543 No 126 >6HS4_B Envelope glycoprotein,Envelope glycoprotein,Envelope glycoprotein, Envelope; Ebola Glycoprotein, Structure-based In Silico; HET: BMA, GON, NAG, GOL, MAN; 2.05A {Zaire ebolavirus (strain Mayinga-76)} Probab=21.34 E-value=84 Score=33.08 Aligned_cols=40 Identities=15% Similarity=0.150 Sum_probs=25.9 Template_Neff=5.300 Q sp|P0DTC2|SPIK 925 NQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 925 nqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) .+....+....++++.....+..+..+|-||..||.-|.- T Consensus 55 ~~l~~~~n~t~~al~~L~~~l~sl~~vvLQNR~aLD~Ll~ 94 (168) T 6HS4_B 55 CGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQ 94 (168) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhhchhHHHHHHH Confidence 3333444445555555566666677889999999987653 No 127 >2KG7_A Uncharacterized protein esxG (PE family; Protein complex, UNKNOWN FUNCTION; NMR {Mycobacterium tuberculosis} Probab=21.11 E-value=85 Score=25.82 Aligned_cols=66 Identities=11% Similarity=0.201 Sum_probs=38.0 Template_Neff=10.300 Q sp|P0DTC2|SPIK 923 IANQFNSAIGKIQDSLSSTASALGKLQDVVN-QNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVE 988 (1273) Q Consensus 923 ianqfnsaigkiqdslsstasalgklqdvvn-qnaqalntlvkqlssnfgaissvlndilsrldkve 988 (1273) .++++.+..+.|++.++.....+..|...-. ..+.+......++...+..+...|+++-..|.+.. T Consensus 14 ~a~~~~~~~~~l~~~~~~l~~~~~~l~~~W~G~a~~af~~~~~~~~~~~~~~~~~L~~~~~~l~~~~ 80 (97) T 2KG7_A 14 SQSAFAAKAGLMRHTIGQAEQAAMSAQAFHQGESSAAFQAAHARFVAAAAKVNTLLDVAQANLGEAA 80 (97) T ss_dssp TTCHHHHHHHHHHHHHHHHHHHHHHHGGGTCSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSTTC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 4555666666666666555555554432222 23445666666666666666666666666665543 No 128 >6W08_B NSP15 endoribnuclease; Tripartite pore forming toxin, Cytotoxin; HET: EDO; 1.75A {Vibrio cholerae O1 biovar El Tor str. N16961} Probab=20.88 E-value=87 Score=32.75 Aligned_cols=55 Identities=15% Similarity=0.317 Sum_probs=27.7 Template_Neff=9.500 Q sp|P0DTC2|SPIK 1139 DPLQPELDSFKEELDKYFKNHTSPDVDLGD--------ISGINASVVNIQKEIDRLNEVAKNL 1193 (1273) Q Consensus 1139 dplqpeldsfkeeldkyfknhtspdvdlgd--------isginasvvniqkeidrlnevaknl 1193 (1273) +.++.+++.|+..|..+...-..-.-++.. ..+.++.+..++++|++|++-.+.+ T Consensus 122 ~~~~~~~~~~~~~l~~f~~~~~~~~~~l~~~~~~~~~~~~~~~~~i~~L~~~I~~l~~~i~~~ 184 (359) T 6W08_B 122 QSLTSNIKRYDEGLNAWARQVEDAHNTLQQTIAQIQQEEVSIQAEIIATNAQIDLMKQQIAAF 184 (359) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCGGGHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 456666667777666554442222222322 1334445556666666665544433 No 129 >3OGI_C Putative ESAT-6-like protein 6, Putative; Structural Genomics, PSI-2, Protein Structure; HET: MSE; 2.549A {Mycobacterium tuberculosis} Probab=20.43 E-value=90 Score=26.79 Aligned_cols=66 Identities=14% Similarity=0.137 Sum_probs=31.7 Template_Neff=9.500 Q sp|P0DTC2|SPIK 921 KLIANQFNSAIGKIQDSLSSTASALGKLQDV-VNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDK 986 (1273) Q Consensus 921 klianqfnsaigkiqdslsstasalgklqdv-vnqnaqalntlvkqlssnfgaissvlndilsrldk 986 (1273) .-.++.+....+.|++.++.....+..|.+. ....+++......++...+..+...|+++-..|+. T Consensus 11 ~~~a~~l~~~~~~l~~~~~~l~~~~~~l~~~W~G~a~~af~~~~~~~~~~~~~~~~~l~~~~~~l~~ 77 (101) T 3OGI_C 11 DAHGAMIRAQAGLLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQA 77 (101) T ss_dssp --CHHHHHHHHHHHHHHHHHHHHHHHHTGGGTTCTTSHHHHHHHHHHHHHHHHHTTCC--------- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3455666666666666666555555555332 22345555566666666666666666666555544 No 130 >5HJ3_L Envelope glycoprotein, KZ52 Antibody Fragment; Ebola virus, EOV, Ebolavirus, GP; HET: MAN, NAG, BMA; 3.3A {Ebola virus sp.} Probab=20.10 E-value=93 Score=31.85 Aligned_cols=35 Identities=17% Similarity=0.174 Sum_probs=23.0 Template_Neff=5.300 Q sp|P0DTC2|SPIK 930 AIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 930 aigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) .+....++++.....+..+..+|-||..||.-|.- T Consensus 60 ~~n~t~~al~~L~~~l~sl~~vvLQNR~aLD~Lla 94 (136) T 5HJ3_L 60 LANETTQALQLFLRATTELRTFSILNRKAIDFLLQ 94 (136) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHhhchHHHHHHHH Confidence 33444455555555566677888999999887653 No 131 >6RX1_A Syncytin-1; HUMAN PLACENTAL PROTEIN, MEMBRANE FUSION; 2.1A {Homo sapiens} Probab=20.03 E-value=93 Score=30.99 Aligned_cols=53 Identities=26% Similarity=0.386 Sum_probs=30.7 Template_Neff=5.000 Q sp|P0DTC2|SPIK 908 GIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 908 gigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) |.|+++.-+. .+..+....+....++++.....+..+..+|-||..||.-|.- T Consensus 12 ~~~~~~~~l~----~L~~~l~~~~n~t~~al~~L~~~l~sl~~vvLQNR~aLD~Ll~ 64 (108) T 6RX1_A 12 FQSTSTQFYY----KLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNRRALDLLTA 64 (108) T ss_dssp ------CHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTG T ss_pred ccchhhHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhchhHHHHHHH Confidence 5555553222 2333444445556666777777777788899999999887653