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view test-data1/minz/NP_000282.1.hhr @ 27:e34da554d415 draft
"planemo upload commit f12d400ea7827bb7d6b2ef31eb7f38e555bd053f-dirty"
| author | guerler |
|---|---|
| date | Sat, 31 Oct 2020 22:46:10 +0000 |
| parents | |
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Query NP_000282.1 Match_columns 417 No_of_seqs 604 out of 4515 Neff 6.98956 Searched_HMMs 787 Date Fri Jul 24 20:35:21 2020 Command /home/guerler/hh-suite/build/bin/hhblits -i /home/guerler/human/fasta/NP_00/NP_000282.1.fasta -d /home/guerler/pdb70/pdb70 -o /home/guerler/human/hhr/NP_00/NP_000282.1.hhr No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 2WZB_A PHOSPHOGLYCERATE KINASE 100.0 9E-114 7E-118 875.1 0.0 415 3-417 2-416 (416) 2 1HDI_A PHOSPHOGLYCERATE KINASE 100.0 4E-113 3E-117 868.7 0.0 412 6-417 2-413 (413) 3 6Y3A_A Phosphoglycerate kinase 100.0 3E-112 2E-116 865.4 0.0 414 2-416 9-423 (424) 4 3UWD_A Phosphoglycerate kinase 100.0 7E-112 6E-116 855.6 0.0 391 4-416 1-393 (394) 5 1QPG_A 3-PHOSPHOGLYCERATE KINA 100.0 7E-112 6E-116 861.3 0.0 413 2-416 1-413 (415) 6 3PGK_A PHOSPHOGLYCERATE KINASE 100.0 8E-112 7E-116 861.3 0.0 413 2-416 2-414 (416) 7 3Q3V_A Phosphoglycerate kinase 100.0 3E-111 3E-115 852.3 0.0 392 2-416 3-399 (403) 8 1PHP_A 3-PHOSPHOGLYCERATE KINA 100.0 1E-110 9E-115 847.6 0.0 387 8-416 5-393 (394) 9 1VPE_A PHOSPHOGLYCERATE KINASE 100.0 1E-110 1E-114 848.4 0.0 392 6-416 2-395 (398) 10 4FEY_A Phosphoglycerate kinase 100.0 6E-110 5E-114 842.0 0.0 388 2-416 2-391 (395) 11 1V6S_B Phosphoglycerate kinase 100.0 1E-109 1E-113 838.8 0.0 386 7-416 2-390 (390) 12 3ZLB_A PHOSPHOGLYCERATE KINASE 100.0 2E-109 1E-113 840.0 0.0 394 4-416 1-397 (398) 13 4EHJ_A Phosphoglycerate kinase 100.0 2E-109 2E-113 837.1 0.0 386 4-416 1-388 (392) 14 16PK_A 3-PHOSPHOGLYCERATE KINA 100.0 4E-109 4E-113 840.3 0.0 395 6-416 2-414 (415) 15 3OZ7_B Phosphoglycerate kinase 100.0 4E-109 4E-113 840.5 0.0 413 3-416 4-417 (417) 16 4DG5_A Phosphoglycerate kinase 100.0 5E-109 4E-113 836.1 0.0 392 5-416 9-402 (403) 17 6HXE_A Phosphoglycerate kinase 100.0 4E-108 4E-112 826.1 0.0 381 4-416 1-383 (387) 18 4NG4_B Phosphoglycerate kinase 100.0 5E-108 4E-112 830.0 0.0 389 1-416 9-399 (404) 19 4NG4_C Phosphoglycerate kinase 100.0 5E-108 4E-112 830.0 0.0 389 1-416 9-399 (404) 20 6I06_A Phosphoglycerate kinase 100.0 1E-107 9E-112 823.4 0.0 381 4-416 1-383 (387) 21 2CUN_A Phosphoglycerate kinase 100.0 3E-105 3E-109 811.0 0.0 387 8-416 3-400 (410) 22 1FW8_A PHOSPHOGLYCERATE KINASE 100.0 8.8E-90 7.6E-94 698.3 0.0 342 74-416 2-343 (416) 23 1FW8_A PHOSPHOGLYCERATE KINASE 99.3 3.2E-16 2.7E-20 156.7 0.0 68 3-70 347-414 (416) 24 2Q33_B D-MONELLIN CHAIN A, D-M 34.3 5.9 0.00042 24.6 0.0 11 310-320 2-12 (48) No 1 >2WZB_A PHOSPHOGLYCERATE KINASE 1 (E.C.2.7.2.3); HEREDITARY HEMOLYTIC ANEMIA, TRANSFERASE, PHOSPHOPROTEIN; HET: ADP, 3PG; 1.47A {HOMO SAPIENS} Probab=100.00 E-value=8.6e-114 Score=875.06 Aligned_cols=415 Identities=100% Similarity=1.449 Sum_probs=363.4 Template_Neff=6.400 Q NP_000282.1 3 LSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVA 82 (417) Q Consensus 3 ~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va 82 (417) +..|++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++..++.+||+||+ T Consensus 2 ~~~~~~l~~~~l~gK~vlvR~D~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGrP~g~~~~~~~Sl~pv~ 81 (416) T 2WZB_A 2 LSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVA 81 (416) T ss_dssp CTTBCBGGGCCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTCSEEEEECCCSCCTTSCCHHHHCSHHHH T ss_pred CcccccccccccCCCEEEEEeEccccccCCccCCChHHHHHHHHHHHHHHCCCCEEEEEeeCCCCCCCCCCcccChHHHH Confidence 45788898889999999999999999998899999999999999999999999448999999999875323479999999 Q NP_000282.1 83 VELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYV 162 (417) Q Consensus 83 ~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyV 162 (417) ++|+++|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|+++++++++|+.+++.+++.+|+++||+++|+|| T Consensus 82 ~~L~~~l~~~v~f~~d~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~~~~n~~k~~~~~~~~fa~~La~l~DiyV 161 (416) T 2WZB_A 82 VELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYV 161 (416) T ss_dssp HHHHHHHTSCCEECSCSSSHHHHHHHHSCCTTEEEECCCGGGSHHHHTCC----------CHHHHHHHHHHHHHTCSEEE T ss_pred HHHHHHhCCEEEEcccCCCHHHHHHHhCCCCCcEEEEeccccchhhcCCCCCCCCccccCCHHHHHHHHHHHhcccceEE Confidence 99999998779999999998888888899999999999999998776331111111111112234679999999999999 Q NP_000282.1 163 NDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAF 242 (417) Q Consensus 163 NDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~ 242 (417) |||||++||.|||++++++|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+||| T Consensus 162 NDAF~~~HR~hAS~vgi~lp~s~aG~ll~kEl~~L~~~~~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~IligG~~a~ 241 (416) T 2WZB_A 162 NDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAF 241 (416) T ss_dssp ECCGGGTTCCCHHHHCCCCSCEEECHHHHHHHHHHHHHHHSCCSSEEEEECSSCHHHHGGGHHHHTTTCSEEEECGGGHH T ss_pred ecccccCCCccccccccCCCccchHHHHHHHHHHHHHHhcCCCCCEEEEEcCCCHHHHHHHHHHHHHhCCEEEeCcHHHH Confidence 99999999999999999976589999999999999999999999999999999999999999999998999999999999 Q NP_000282.1 243 TFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSK 322 (417) Q Consensus 243 tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~ 322 (417) +||+|++++++|+|++|++..+.|++++++|+.++++|+||+|++|.+.+..+.....+.....+|++|+++||||+|++ T Consensus 242 tfL~a~~~~~ig~S~~e~~~~~~a~~il~~a~~~~~kI~LP~D~vv~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~ 321 (416) T 2WZB_A 242 TFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSK 321 (416) T ss_dssp HHHHHHHCCCCTTSCCCHHHHTTHHHHHHHHHHTTCEEECCCEEEEESSSSTTCCEEEEETTTCCCTTCEEEEECHHHHH T ss_pred HHHHHhCCCccccceecchHHHHHHHHHHHHHHcCCEEEceeeEEecccccccccCCeeeecCCCCCCceeecCCHHHHH Confidence 99999856689999999999999999999988999999999999999865332211111112378899999999999999 Q NP_000282.1 323 KYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLEL 402 (417) Q Consensus 323 ~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~ 402 (417) .|+++|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+||| T Consensus 322 ~~~~~I~~aktI~wNGP~G~~E~~~f~~GT~~ia~al~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~L~~ 401 (416) T 2WZB_A 322 KYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLEL 401 (416) T ss_dssp HHHHHHHHCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHTTCEEEEESTTHHHHHHHTTCTTSSSEEESCSHHHHHH T ss_pred HHHHHHHhCCEEEEcCCCCcccchhhchHHHHHHHHHHHHhcCCcEEEEecccHHHHHHHcCCCccCeEEecCcHHHHHH Confidence 99999999999999999999998889999999999997632247899999999999998889888899999999999999 Q NP_000282.1 403 LEGKVLPGVDALSNI 417 (417) Q Consensus 403 L~G~~LPgl~aL~~~ 417 (417) |+|++||||++|+++ T Consensus 402 L~G~~LPgieaL~~~ 416 (416) T 2WZB_A 402 LEGKVLPGVDALSNI 416 (416) T ss_dssp HHTCCCHHHHTSCBC T ss_pred HcCCCCchHHHHhcC Confidence 999999999999875 No 2 >1HDI_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); PHOSPHOTRANSFERASE, KINASE, PHOSPHOGLYCERATE, TERNARY COMPLEX; HET: AMP, 3PG; 1.8A {SUS SCROFA} SCOP: c.86.1.1 Probab=100.00 E-value=4.1e-113 Score=868.67 Aligned_cols=412 Identities=91% Similarity=1.360 Sum_probs=361.3 Template_Neff=6.300 Q NP_000282.1 6 KLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVEL 85 (417) Q Consensus 6 ~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L 85 (417) +++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++..++.+||+||+++| T Consensus 2 ~~~l~~~~l~gK~vlvR~D~NVPi~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGRP~g~~~~~~~Sl~pva~~L 81 (413) T 1HDI_A 2 KLTLDKLNVKGKRVVMRVDFNVPMAAAQITNNARIKAAVPSIKFCLDDGAKSVVLMSHLGRPDGSPMPDKYSLQPVAAEL 81 (413) T ss_dssp BCBGGGSCCTTCEEEEECCCCCCBSSSSBSCCHHHHHHHHHHHHHHHTTCSEEEEECCCSCCCSSCCTTTSCSHHHHHHH T ss_pred CccccccccCCCEEEEEeecCccccccccCCChHHHHHHHHHHHHHHCCCCEEEEEeeCCCCCCCCCCcccccHHHHHHH Confidence 56777788999999999999999988899999999999999999999999448999999999875323479999999999 Q NP_000282.1 86 KSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDA 165 (417) Q Consensus 86 ~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDA 165 (417) +++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++++++++|+.+.+.+++.+|++.||+++|+||||| T Consensus 82 ~~~l~~~V~f~~d~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~~~~n~~~~~~~~~~~fa~~La~l~DiyVnDA 161 (413) T 1HDI_A 82 KSALGKAVLFLKDCVGPAVEKACADPAAGSVILLENLRFHVEEEGKGKDASGNKAAGEPAKIKAFRASLSALGDVYVNDA 161 (413) T ss_dssp HHHHTSCCEECSCSSSHHHHHHHHSCCTTEEEECCCGGGSHHHHTEEECTTSCEEECCHHHHHHHHHHHHHTCSEEEECC T ss_pred HHHhCCEEEEccccCCHHHHHHhhCCCCCCEEEeeccccchhhcCCCCCCCcccccCCHHHHHHHHHHHHhccccEeecc Confidence 99998779999999998888888999999999999999999776331100011101111224679999999999999999 Q NP_000282.1 166 FGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFL 245 (417) Q Consensus 166 Fg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~tfl 245 (417) |+++||.|||++++++|+++||++|++||++|.+++++|+||+++|+||+|++||+++|++|+++||.|++||+|||+|| T Consensus 162 F~~~HR~hAS~vgi~lp~~~aG~l~~kEi~~L~~~~~~p~rP~v~IlGGaKv~dKi~li~~Ll~~~D~IliGG~~a~tFL 241 (413) T 1HDI_A 162 FGTAHRAHSSMVGVNLPKKAGAFLMKKELNYFAAAAESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFL 241 (413) T ss_dssp GGGTTCCCHHHHCCCCSCEEECHHHHHHHHHHHHHHTSCCSSEEEEECCSCSGGGHHHHHHHHTTCSEEEECGGGHHHHC T ss_pred cccCCCCCCCccccCCchhHHHHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHHcCCEEEECchHHHHHH Confidence 99999999999999986579999999999999999999999999999999999999999999999999999999999999 Q NP_000282.1 246 KVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYA 325 (417) Q Consensus 246 ~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~~~~ 325 (417) +|++++++|+|++|++..+.|++++++|+.++++|++|+|++|.+.+..+...........+|++|+++||||+|++.|+ T Consensus 242 ~a~g~~~iG~Sl~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~~~~~~~~~ip~~~~ilDIGp~Ti~~~~ 321 (413) T 1HDI_A 242 KVLNNMEIGTSLFDEAGKKIVKNLMSKAAANGVKITLPVDFVTADKFDEQAKIGQATVASGIPAGWMGLDCGPKSSAKYS 321 (413) T ss_dssp CCCCCCCBTTCCCCTTGGGTHHHHHHHHHHHTCEEECCCEEEEESSSSTTCCEEEEETTTCBCTTCEEEEECHHHHHHHH T ss_pred HHhCCCcccceeechhHHHHHHHHHHHHHHCCCeEEceeeEEeccccchhcccceeeecCCCCCCcccccCCHHHHHHHH Confidence 99855689999999999999999999988999999999999999875432211111112378899999999999999999 Q NP_000282.1 326 EAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEG 405 (417) Q Consensus 326 ~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~L~G 405 (417) ++|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+||||+| T Consensus 322 ~~I~~aktI~wnGP~G~~E~~~f~~GT~~ia~~i~~~~~~~a~sivGGGdT~~~~~~~g~~~~~~~vSTGGGA~Le~L~g 401 (413) T 1HDI_A 322 EAVARAKQIVWNGPVGVFEWEAFAQGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDNVSHVSTGGGASLELLEG 401 (413) T ss_dssp HHHHHCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHTTCEEEECTTHHHHHHHHTTCTTTSSEECSCHHHHHHHHTT T ss_pred HHHHhCCEEEEeCCCCcccchhhchHHHHHHHHHHHHhcCCcEEEEecccHHHHHHHcCCCCCCEEEecChHHHHHHHcC Confidence 99999999999999999988789999999999997632247899999999999888888888899999999999999999 Q NP_000282.1 406 KVLPGVDALSNI 417 (417) Q Consensus 406 ~~LPgl~aL~~~ 417 (417) +.||||++|+++ T Consensus 402 k~LPgi~aL~~~ 413 (413) T 1HDI_A 402 KVLPGVDALSNV 413 (413) T ss_dssp CCCHHHHTSCBC T ss_pred CCCchHHHhhcC Confidence 999999999874 No 3 >6Y3A_A Phosphoglycerate kinase (E.C.2.7.2.3); phosphoglycerate kinase, metabolic enzyme, kinase; 1.49A {Plasmodium vivax} Probab=100.00 E-value=2.6e-112 Score=865.36 Aligned_cols=414 Identities=59% Similarity=0.970 Sum_probs=363.7 Template_Neff=6.300 Q NP_000282.1 2 SLSNKLTLDKL-DVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEP 80 (417) Q Consensus 2 ~~~~~~~i~~~-~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~ 80 (417) ++.+++++.|. |++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++. .+++||+| T Consensus 9 ~~~~~~~~~~~~~l~gK~vlvRvD~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGRP~g~~-~~~~Sl~p 87 (424) T 6Y3A_A 9 SLGNKLSITDVKAIQGKKVLVRVDFNVPIENGVIKDTNRITATLPTIHHLKKEGAAKIILISHCGRPDGTK-NLKYTLKP 87 (424) T ss_dssp CCTTBCBGGGCCCCTTCEEEEECCCCCCEETTEESCCHHHHTTHHHHHHHHHTTCSEEEEECCCSCCTTSC-CGGGCSHH T ss_pred cCCCCccccchHHhCCCEEEEEeecCCcccCCccCCChHHHhHHHHHHHHHHCCCCEEEEEeeCCCCCCCc-cccccHHH Confidence 46788999997 89999999999999999888999999999999999999999994499999999998764 56899999 Q NP_000282.1 81 VAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDV 160 (417) Q Consensus 81 va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Di 160 (417) |+++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++++++++|+.++..+++.+|+++||+++|+ T Consensus 88 va~~L~~~l~~~v~f~~d~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~~~~n~~~~~~~~~~~fa~~LA~l~Di 167 (424) T 6Y3A_A 88 VAETLGTLLGEEVLFLSDCVGEEVAAQINQAKDNSVILLENLRFHVEEEGKGVDAAGNKIKASKEDMEKFQNELTKLGDV 167 (424) T ss_dssp HHHHHHHHHTSCCEECSCSSSHHHHHHHHHSCTTEEEECCCGGGSHHHHSEEECTTSCEEECCHHHHHHHHHHHHTTCSE T ss_pred HHHHHHHHhCCEEEeccccCCHHHHHHHHhccCCCEEEeccccccchhccCCccccccccccCHHHHHHHHHHHhhccCe Confidence 99999999987799999999988888889999999999999999987753211101121111122346799999999999 Q NP_000282.1 161 YVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGM 240 (417) Q Consensus 161 yVNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~ 240 (417) |||||||++||.|||+++++.+.++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+| T Consensus 168 yVNDAF~~~HR~hAS~vgi~~~~s~aG~llekEl~~L~k~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~vD~IligG~~ 247 (424) T 6Y3A_A 168 FINDAFGTAHRAHSSMVGIKMNVKASGFLMKKELEYFSKALENPQRPLLAILGGAKVSDKIQLIKNLLDKVDKMIIGGGM 247 (424) T ss_dssp EEECCGGGTTSCCHHHHCCCCSCEEECHHHHHHHHHHHHHHTSCCSSEEEEEECSCSGGGHHHHHHHHTTCSEEEEESTH T ss_pred EEecccccCccccCcchHHhccHHHhcHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHHcCCEEEECcHH Confidence 99999999999999999999322899999999999999999999999999999999999999999999989999999999 Q NP_000282.1 241 AFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPES 320 (417) Q Consensus 241 a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~T 320 (417) ||+||+|++++++|+|++|++..+.|++++++|+.++++|++|+|++|.+.+..+.....+.....+|++|+++||||+| T Consensus 248 a~tfL~a~~~~~ig~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~T 327 (424) T 6Y3A_A 248 AYTFKYVLNNMKIGDSLFDEAGSKIVNEIMEKAKAKNVEIYLPVDFKVADKFDNNANTKVVTDEEGIEDKWMGLDAGPKS 327 (424) T ss_dssp HHHHHHHHHCCCBTTSCCCHHHHTTHHHHHHHHHHTTCEEECCSEEEEESSSSTTSCEEEEETTTCBCTTCEEEEECHHH T ss_pred HHHHHHHHCCCcccchhccchhHHHHHHHHHHHHHCCCeEEeeeeeeeccccCCCCCceEecCccCCCCCcccccCCHHH Confidence 99999997455799999999889999999999989999999999999998753322111122224788999999999999 Q NP_000282.1 321 SKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASL 400 (417) Q Consensus 321 i~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~L 400 (417) ++.|.+.|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+| T Consensus 328 i~~~~~~I~~aktI~wNGP~G~~E~e~f~~GT~~ia~al~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~L 407 (424) T 6Y3A_A 328 IENYKDVILSSKTIIWNGPQGVFEMPNFAKGSIECLNLVIEATKKGAISIVGGGDTASLVEQQQKKNEISHVSTGGGASL 407 (424) T ss_dssp HHHHHHHHHTCSEEEEESCSBCTTSGGGCHHHHHHHHHHHHHHHTTCEEEECSHHHHHHHHHTTCGGGSSEECCCTHHHH T ss_pred HHHHHHHHHhCCEEEEeCCCCcccCCCcchhHHHHHHHHHHHhcCCCEEEEechHHHHHHHHhccccCcEEEEechhHHH Confidence 99999999999999999999999988899999999999976322478999999999999988888788999999999999 Q NP_000282.1 401 ELLEGKVLPGVDALSN 416 (417) Q Consensus 401 e~L~G~~LPgl~aL~~ 416 (417) |||+|+.||||++|++ T Consensus 408 e~L~G~~LPgieaL~~ 423 (424) T 6Y3A_A 408 ELLEGKELPGVVALSS 423 (424) T ss_dssp HHHTTCCCHHHHTSCB T ss_pred HHHcCCCCChhHHhhc Confidence 9999999999999975 No 4 >3UWD_A Phosphoglycerate kinase (E.C.2.7.2.3); Anthrax, Structural Genomics, Center for; HET: BTB, MSE; 1.68A {Bacillus anthracis} Probab=100.00 E-value=6.9e-112 Score=855.65 Aligned_cols=391 Identities=48% Similarity=0.845 Sum_probs=357.0 Template_Neff=6.400 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |++++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++. .+.+||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vlvR~D~NVPi~~~~i~dd~RI~~~lpTI~~L~~~ga-kvil~sHlGrP~g~~-~~~~sl~~va~ 78 (394) T 3UWD_A 1 MNKKSIRDVDLKGKRVFCRVDFNVPMKEGKITDETRIRAALPTIQYLVEQGA-KVILASHLGRPKGQA-VEELRLTPVAA 78 (394) T ss_dssp CCBCBGGGSCCTTCEEEEECCCCCCC--CCCCCCHHHHHTHHHHHHHHHTTC-EEEEECCCSCCTTSC-CGGGCSHHHHH T ss_pred CCCccccccccCCCEEEEEeecCccccCCCcCCcHHHHHHHHHHHHHHHCCC-cEEEEeccCCCCCcc-chhhChHHHHH Confidence 4567888888999999999999999987899999999999999999999999 599999999999864 56899999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVN 163 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVN 163 (417) +|+++|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|+++ +.+|++.||+++|+||| T Consensus 79 ~L~~~l~~~v~f~~~~~g~~~~~~i~~~~~g~i~lLENlRf~~~E~~n---------------d~~fa~~La~l~DiyVn 143 (394) T 3UWD_A 79 RLGELLGKDVKKADEAFGPVAQEMVAAMNEGDVLVLENVRFYAGEEKN---------------DAELAKEFAALADIFVN 143 (394) T ss_dssp HHHHHHTSCCEECSCSSSHHHHHHHHTCCTTCEEECCCGGGSHHHHHT---------------CHHHHHHHHTTCSEEEE T ss_pred HHHHHHCCEEeecCccccHHHHHHHHHccCCCEEEEecccccCccccc---------------cHHHHHHHHHhccHHHh Confidence 999999877999999999888888899999999999999999876532 36799999999999999 Q NP_000282.1 164 DAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 164 DAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) ||||++||.|||+++++ +| ++||++|++|+++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+|| T Consensus 144 DAF~~~HR~hAS~~gi~~~lp-s~aG~ll~kEl~~L~~~~~~p~~P~v~IlGGaKv~dKi~~i~~Ll~~~d~iligG~~a 222 (394) T 3UWD_A 144 DAFGAAHRAHASTAGIADYLP-AVSGLLMEKELEVLGKALSNPERPFAAIIGGAKVKDKIGLIRHLLDKVDNLIIGGGLA 222 (394) T ss_dssp CCGGGTTSCCTTTTGGGGTSC-EEECHHHHHHHHHHHHHHHSCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEECSTTH T ss_pred ccHhHhcccccchhhHhhhhH-hhhcHHHHHHHHHHHHHHhCCCCCEEEEECCCCHHHHHHHHHHHHHhCCEEEECChHH Confidence 99999999999999999 77 8999999999999999999999999999999999999999999999999999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+++...+.. .+...+.+|++|+++||||+|+ T Consensus 223 ~tfL~a~-g~~iG~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~~DIGp~Ti 300 (394) T 3UWD_A 223 YTFVKAL-GHEIGLSLCEDDKIELAKEFMQLAKEKGVNFYMPVDVVITEEFSETATT-KIVGIDSIPSNWEGVDIGPKTR 300 (394) T ss_dssp HHHHHHT-TCCCTTCCCCGGGHHHHHHHHHHHHHHTCEEECCSEEEEESSCSTTCCE-EEEEGGGCCTTCEEEEECHHHH T ss_pred HHHHHHh-CCcccccccchHHHHHHHHHHHHHHHcCCeEEceeeEEeccccCcccce-EEeccccCCCCceeecCCHHHH Confidence 9999998 8999999999999999999999988899999999999999875432211 1222357889999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|.++|++|||||||||||+||.++|++||+++++++++++ ++++|+|||||+++++++|+.++++||||||||+|| T Consensus 301 ~~~~~~I~~aktI~wnGP~G~~E~e~f~~GT~~i~~ai~~~~--~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~Le 378 (394) T 3UWD_A 301 EIYADVIKNSKLVVWNGPMGVFEMTPFAEGTKAVGQALADAE--GTYSVIGGGDSAAAVEKFGMADKMSHISTGGGASLE 378 (394) T ss_dssp HHHHHHHHTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHCT--TCEEEECSHHHHHHHHHTTCGGGCSEECCCTHHHHH T ss_pred HHHHHHHhcCCEEEEECCCCcccCCCcChHHHHHHHHHHHcC--CCeEEEechHHHHHHHHcCCCCcceEEEcccHHHHH Confidence 999999999999999999999988889999999999997632 689999999999888888888889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|++||||++|++ T Consensus 379 ~L~Gk~LPgl~aL~~ 393 (394) T 3UWD_A 379 FMEGKELPGVVCLND 393 (394) T ss_dssp HHTTCCCHHHHTSCB T ss_pred HHcCCCCCchhhhcc Confidence 999999999999985 No 5 >1QPG_A 3-PHOSPHOGLYCERATE KINASE, MAGNESIUM-5'-ADENYLY-IMIDO-TRIPHOSPHATE, 3-PHOSPHOGLYCERIC ACID; PHOSPHOTRANSFERASE (CARBOXYL ACCEPTOR), KINASE, GLYCOLYSIS; HET: 3PG, MAP; 2.4A {Saccharomyces cerevisiae} SCOP: c.86.1.1 Probab=100.00 E-value=7.2e-112 Score=861.28 Aligned_cols=413 Identities=66% Similarity=1.036 Sum_probs=363.5 Template_Neff=6.500 Q NP_000282.1 2 SLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPV 81 (417) Q Consensus 2 ~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~v 81 (417) +..++++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++. ++.+||+|| T Consensus 1 ~~~~~~~i~~~~l~gK~vlvRvD~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGrP~g~~-~~~~Sl~pv 79 (415) T 1QPG_A 1 SLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVLEHHPRYVVLASHLGQPNGER-NEKYSLAPV 79 (415) T ss_dssp CTTSBCBGGGCCCTTCEEEEECCCCCCBSSSSBSCCHHHHHHHHHHHHHHTTCCSEEEEECCCSCCCSSC-CGGGCSHHH T ss_pred CCcccccccccccCCCEEEEEEecCCccCCCccCCCHHHHHHHHHHHHHHHcCCCEEEEEeeCCCCCCCc-CcccchHHH Confidence 3567889998999999999999999999888999999999999999999999994489999999998764 568999999 Q NP_000282.1 82 AVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVY 161 (417) Q Consensus 82 a~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Diy 161 (417) +++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++.++ ++.+.+++.+++.+|+++||+++|+| T Consensus 80 a~~L~~~l~~~v~f~~d~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~-n~~~~~~~~~~~~~fa~~LA~l~Diy 158 (415) T 1QPG_A 80 AKELQSLLGKDVTFLNDCVGPEVEAAVKASAPGSVILLENLRYHIEEEGSRKV-DGQKVKASKEDVQKFRHELSSLADVY 158 (415) T ss_dssp HHHHHHHHTSCCEEESCSSSHHHHHHHHTCCTTEEEEECCGGGSHHHHTEEEE-TTEEEECCHHHHHHHHHHHHHTCSEE T ss_pred HHHHHHHhCCeEEEccCCCCHHHHHHHHhCCCCCeEehhhhhhcchhcccccc-CCccccCCHHHHHHHHHHHHhcCCeE Confidence 99999999877999999999888888899999999999999999877532000 00000111223478999999999999 Q NP_000282.1 162 VNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 162 VNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) ||||||++||.|||++++++|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+|| T Consensus 159 VNDAF~~~HR~hAS~vgi~lp~s~aG~ll~kEl~~L~k~l~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~IligG~~a 238 (415) T 1QPG_A 159 INDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMA 238 (415) T ss_dssp EECCGGGTTSCCHHHHCCCCSCEEECHHHHHHHHHHHHHHSSCCSSEEEEECSSCSGGGHHHHHHHTTTCSEEEECGGGH T ss_pred eecccccCCcccccceecCCChhhhcHHHHHHHHHHHHHhhCCCCCEEEEEcCCCHHHHHHHHHHHHHhCCEEEECcHHH Confidence 99999999999999999997658999999999999999999999999999999999999999999999899999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|++++++|+|++|++..+.|++++++|+.++++|+||+|++|.+.+..+.....+...+.+|++|+++||||+|+ T Consensus 239 ~tfL~a~~~~~iG~S~~e~~~~~~a~~il~~a~~~~~ki~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 318 (415) T 1QPG_A 239 FTFKKVLENTEIGDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADANTKTVTDKEGIPAGWQGLDNGPESR 318 (415) T ss_dssp HHHHHHHSCCCCCSCCCCHHHHHHHHHHHHHHHHHTCEEECCSEEEEESSSSSSCCCCEEETTTCCCTTCEEEEECHHHH T ss_pred HHHHHHhCCCcCCccccchhhhhHHHHHHHHHHHcCCeEEeeeeEEEecccCCCCCCceeeccCCCCCCCcccccCHHHH Confidence 99999975558999999998889999999998899999999999999886532221111112237889999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|.+.|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+|| T Consensus 319 ~~~~~~i~~aktI~wnGP~G~~E~~~f~~GT~~ia~~i~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vSTgGGA~L~ 398 (415) T 1QPG_A 319 KLFAATVAKAKTIVWNGPPGVFEFEKFAAGTKALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLE 398 (415) T ss_dssp HHHHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHHTCEEEECCHHHHHHHHHTTCGGGSSEECCCTHHHHH T ss_pred HHHHHHHHcCCEEEEcCCCChhcccccChHHHHHHHHHHHHhcCCCeEEEEehHHHHHHHHcCCCCccEEEEcCchHHHH Confidence 99999999999999999999999888999999999999763224789999999999999888987889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|+.||||++|++ T Consensus 399 ~L~G~~LPgieaL~~ 413 (415) T 1QPG_A 399 LLEGKELPGVAFLSE 413 (415) T ss_dssp HHTSCCCHHHHTSCB T ss_pred HHcCCCCChHHHHhh Confidence 999999999999975 No 6 >3PGK_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); PHOSPHOTRANSFERASE(CARBOXYL AS ACCEPTOR), TRANSFERASE; HET: ATP, 3PG; 2.5A {Saccharomyces cerevisiae} SCOP: c.86.1.1 Probab=100.00 E-value=7.8e-112 Score=861.30 Aligned_cols=413 Identities=64% Similarity=1.016 Sum_probs=363.8 Template_Neff=6.500 Q NP_000282.1 2 SLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPV 81 (417) Q Consensus 2 ~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~v 81 (417) +..++++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++. ++.+||+|| T Consensus 2 ~~~~~~~~~~~~l~gK~vlvRvD~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~gak~vil~sHlGRP~g~~-~~~~Sl~pv 80 (416) T 3PGK_A 2 SLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVLEHHPRYVVLASHLGRPNGER-NEKYSLAPV 80 (416) T ss_dssp CCCCSCCSSCCCCSSCCEEEECCCCCCCSSSCCSCCHHHHHHHHHHHHHHHHCCSCCEEECCCCCCCSSS-SCSCCSHHH T ss_pred CCcccccccccccCCCEEEEEEecCCccCCCccCCCHHHHHHHHHHHHHHHcCCCEEEEEeecCCCCCCc-CcccChHHH Confidence 5678899999999999999999999999888999999999999999999999994489999999998764 568999999 Q NP_000282.1 82 AVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVY 161 (417) Q Consensus 82 a~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Diy 161 (417) +++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++.++ ++.+.+++.+++.+|++.||+++|+| T Consensus 81 a~~L~~~l~~~v~f~~d~~g~~~~~~i~~~~~g~i~lLENlRF~~~E~~~~~~-n~~~~~~~~~~~~~fa~~La~l~diy 159 (416) T 3PGK_A 81 AKELQSLLGKDVTFLNDCVGPEVEAAVKASAPGSVILLENLRYHIEEEGSRKV-DGQKVKASKEDVQKFRHELSSLADVY 159 (416) T ss_dssp HHHHHHHHCSCEECCCSSCCHHHHHHHHHSSSCEEEECSSCSSCSSCCCCSSS-SSSSCCCCCHHHHHHHHHHHTSCSEE T ss_pred HHHHHHHHCCeeEEcccCCCHHHHHHHHhCCCCCeEehhhhhhcchhcccccc-CCcccccCHHHHHHHHHHHHhcCCeE Confidence 99999999877999999999888888899999999999999999877522000 00001111223477999999999999 Q NP_000282.1 162 VNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 162 VNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) ||||||++||.|||++++++|+++||++|++||++|.+++++|+||+++|+||+|++||+++|++|+++||.|++||+|| T Consensus 160 VNDAF~~~HR~hAS~vgi~lp~s~aG~ll~kEl~~L~k~l~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~iligG~~a 239 (416) T 3PGK_A 160 INDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMA 239 (416) T ss_dssp EECSSCSSSSCCTTSSSCCSSCEEECHHHHHHHHHHHHHTSCCSSCBEEEECSSCCSTHHHHHHHHHSSSSCEEEECCHH T ss_pred eecccccCCccccCccccCCchhhhcHHHHHHHHHHHHHhhCCCCCEEEEEcCCCHHHHHHHHHHHHHhCCEEEeCcHHH Confidence 99999999999999999997658999999999999999999999999999999999999999999999899999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|++++++|+|++|++..+.|++++++|+.++++|+||+|++|.+.+........+...+.+|++|+++||||+|+ T Consensus 240 ~tfL~a~~~~~iG~s~~e~~~~~~a~~il~~a~~~~~kI~LP~D~vv~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 319 (416) T 3PGK_A 240 FTFKKVLENTEIGDSIFDKAVGPEIAKLMEKAKAKGVEVVLPVDFIIADAFSASANTKTVTDKEGIPAGWQGLDNGPESR 319 (416) T ss_dssp HHHHHSSHHHHHHCSCSCTTHHHHHHHHHHHHHHHTCEECCCSEEEECSSSSSSSCEEEESSCCSSSCSSCCCSCCHHHH T ss_pred HHHHHHhCCCccCcchhcccchHHHHHHHHHHHHcCCeEEccccEEEeccccccCCcceeecccCCCCCCccccCCHHHH Confidence 99999975568999999998889999999988889999999999999886532221111112237888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|.+.|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+|| T Consensus 320 ~~~~~~i~~aktI~wnGP~G~~E~~~f~~GT~~ia~~i~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~L~ 399 (416) T 3PGK_A 320 KLFAATVAKATVILWNGPPGVFEFEKFAAGTKALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLE 399 (416) T ss_dssp HHHHHHHSSCSBEEECSCSSCTTSTTSSSHHHHHHHHHHHHTTSSCCEEECSSHHHHHHHHHCCTTCCEECCCSHHHHHH T ss_pred HHHHHHHHhCCEEEEeCCCChhhccccchHHHHHHHHHHHHccCCCeEEEEehhHHHHHHHcCCCCcceEEecChhHHHH Confidence 99999999999999999999999888999999999999763224789999999999999888987889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|+.||||++|++ T Consensus 400 ~L~Gk~LPgl~aL~~ 414 (416) T 3PGK_A 400 LLEGKELPGVAFLSE 414 (416) T ss_dssp HHHTCCCHHHHHCSS T ss_pred HHcCCCCChHHHHhc Confidence 999999999999975 No 7 >3Q3V_A Phosphoglycerate kinase (E.C.2.7.2.3); Structural Genomics, Center for Structural; HET: SO4, FMT, PGE; 2.145A {Campylobacter jejuni subsp. jejuni NCTC 11168} Probab=100.00 E-value=3.2e-111 Score=852.34 Aligned_cols=392 Identities=45% Similarity=0.820 Sum_probs=356.7 Template_Neff=6.300 Q NP_000282.1 2 SLSNKLTLDKLDVKGKRVVMRVDFNVPMKN-NQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEP 80 (417) Q Consensus 2 ~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~-~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~ 80 (417) +|+++++++|.|++|||||||+|+|||+++ ++|.|++||++++|||+||+++|| +|||+||+|||+++ ++.+||+| T Consensus 3 ~~~~~~~l~~~~l~gK~vlvR~D~NVPi~~~~~i~dd~RI~~~lpTI~~Ll~~ga-~vil~sHlGrP~~~--~~~~Sl~~ 79 (403) T 3Q3V_A 3 AMSDIISIKDIDLAKKKVFIRCDFNVPQDDFLNITDDRRIRSAIPTIRYCLDNGC-SVILASHLGRPKEI--SSKYSLEP 79 (403) T ss_dssp ---CBCBGGGSCCTTCEEEEECCCCCCBCTTCCBSCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCSSC--CGGGCSHH T ss_pred cccccccccchhcCCCEEEEEeecCCCcccCCccCCChHHHHHHHHHHHHHHCCC-EEEEEecCCCCccc--CcccCHHH Confidence 578899999889999999999999999975 489999999999999999999999 59999999999865 35899999 Q NP_000282.1 81 VAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDV 160 (417) Q Consensus 81 va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Di 160 (417) |+++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++ +.+|++.||+++|+ T Consensus 80 va~~L~~~l~~~V~f~~~~~g~~~~~~i~~~~~g~i~lLENlRF~~~E~~n---------------~~~fa~~La~l~Di 144 (403) T 3Q3V_A 80 VAKRLARLLDKEIVMAKDVIGEDAKTKAMNLKAGEILLLENLRFEKGETKN---------------DENLAKELASMVQV 144 (403) T ss_dssp HHHHHHHHHTSCCEECSSSSSHHHHHHHHHCCTTCEEECSCGGGSTTGGGT---------------CHHHHHHHHHTCSE T ss_pred HHHHHHHHhCCeeeecCCCCCHHHHHHHHhccCCCEEEEcccccCCcccCC---------------CHHHHHHHHhhchH Confidence 999999999877999999999888888889999999999999999876422 36799999999999 Q NP_000282.1 161 YVNDAFGTAHRAHSSMVGVN--LPQ--KAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMII 236 (417) Q Consensus 161 yVNDAFg~aHR~~aS~~gi~--l~~--~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~ili 236 (417) |||||||++||.|||+++++ +|+ ++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||.|+| T Consensus 145 yVNDAF~~~HR~hAS~vgi~~~lp~~~s~aG~ll~kEl~~L~~~~~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~ili 224 (403) T 3Q3V_A 145 YINDAFGVCHRAHSSVEAITKFFDEKHKGAGFLLQKEIDFASNLIKHPARPFVAVVGGSKVSGKLQALTNLLPKVDKLII 224 (403) T ss_dssp EEECCGGGTTSCCTTTTGGGGGSCTTSEEECHHHHHHHHHHHHHTTCCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEE T ss_pred HHhcccccccccCcchhHHHhhcccccccccHHHHHHHHHHHHHHhCCCCCEEEEECCCcHHHHHHHHHHHHHhCCEEEE Confidence 99999999999999999998 663 79999999999999999999999999999999999999999999999999999 Q NP_000282.1 237 GGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDC 316 (417) Q Consensus 237 gG~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DI 316 (417) ||+|||+||+|+ |+++|+|++|++..+.|++++++|++++++|++|+|++|.+++..++.. ...+...+|++|+++|| T Consensus 225 gG~~a~tfL~a~-g~~iG~s~~e~~~~~~a~~il~~a~~~~~kI~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~~DI 302 (403) T 3Q3V_A 225 GGGMAFTFLKAL-GYDIGNSLLEEELLEEANKILTKGKNLGVKIYLPVDVVAAPACSQDVPM-KFVPAQEIPNGWMGLDI 302 (403) T ss_dssp CSTTHHHHHHHT-TCCCTTSCCCGGGHHHHHHHHHHHHHTTCEEECCSEEEEESSSSTTSCC-EEEEGGGCCTTCEEEEE T ss_pred cchHHHHHHHHc-CCCCccchhhHHHHHHHHHHHHHHHHhCCeeEeeccEEecCcCCCCCCc-eeechhhcCCCccCccC Confidence 999999999998 8999999999999999999999998999999999999999865322211 11122478889999999 Q NP_000282.1 317 GPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGG 396 (417) Q Consensus 317 Gp~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgG 396 (417) ||+|++.|.+.|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++|+.++++|||||| T Consensus 303 Gp~Ti~~~~~~i~~aktI~wnGp~G~~E~e~f~~GT~~i~~~i~~~---~a~~ivGGGdT~~~~~~~g~~~~~~~vStGG 379 (403) T 3Q3V_A 303 GPASVRLFKEVISDAQTIWWNGPMGVFEIDKFSKGSIKMSHYISEG---HATSVVGGGDTADVVARAGDADEMTFISTGG 379 (403) T ss_dssp CHHHHHHHHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHS---SSEEEEESHHHHHHHHHTTCGGGSSEECCCH T ss_pred CHHHHHHHHHHHhhCCEEEEeCCCCcccccccchHHHHHHHHHHhC---CCeEEEeCHHHHHHHHHcCCCccccEEecch Confidence 9999999999999999999999999999878999999999999762 6899999999999999889888899999999 Q NP_000282.1 397 GASLELLEGKVLPGVDALSN 416 (417) Q Consensus 397 gA~Le~L~G~~LPgl~aL~~ 416 (417) ||+||||+|++||||++|++ T Consensus 380 GA~Le~L~Gk~LPgi~aL~~ 399 (403) T 3Q3V_A 380 GASLELIEGKELPGVKALRS 399 (403) T ss_dssp HHHHHHHTTCCCHHHHTTBC T ss_pred HHHHHHHcCCCCchHHHHhh Confidence 99999999999999999975 No 8 >1PHP_A 3-PHOSPHOGLYCERATE KINASE (PGK) (E.C.2.7.2.3); KINASE; HET: ADP; 1.65A {Geobacillus stearothermophilus} SCOP: c.86.1.1 Probab=100.00 E-value=1.1e-110 Score=847.59 Aligned_cols=387 Identities=48% Similarity=0.853 Sum_probs=355.2 Template_Neff=6.500 Q NP_000282.1 8 TLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKS 87 (417) Q Consensus 8 ~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L~~ 87 (417) +++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++. .+.+||+||+++|++ T Consensus 5 ~l~~~~l~gK~vl~R~D~NVpi~~~~i~d~~RI~~~lpTI~~Ll~~ga-kvvl~sHlGrP~g~~-~~~~Sl~~va~~L~~ 82 (394) T 1PHP_A 5 TIRDVDVRGKRVFCRVDFNVPMEQGAITDDTRIRAALPTIRYLIEHGA-KVILASHLGRPKGKV-VEELRLDAVAKRLGE 82 (394) T ss_dssp BGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCSSC-CGGGCSHHHHHHHHH T ss_pred cccccccCCCEEEEEeecCCcccCCCCCCcHHHHHHHHHHHHHHHCCC-cEEEEeccCCCCCCc-chhhhHHHHHHHHHH Confidence 777788999999999999999988899999999999999999999999 599999999998764 468999999999999 Q NP_000282.1 88 LLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFG 167 (417) Q Consensus 88 ~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDAFg 167 (417) +|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|+++ +.+|++.||+++|+||||||| T Consensus 83 ~l~~~v~f~~~~~g~~~~~~i~~~~~g~illLENlRf~~~E~~n---------------~~~fa~~La~l~DiyVnDAF~ 147 (394) T 1PHP_A 83 LLERPVAKTNEAVGDEVKAAVDRLNEGDVLLLENVRFYPGEEKN---------------DPELAKAFAELADLYVNDAFG 147 (394) T ss_dssp HHTSCCEECSCSSSHHHHHHHHTCCTTCEEECCCGGGSHHHHHT---------------CHHHHHHHHTTCSEEEECCGG T ss_pred HhCCCeeecCCCCCHHHHHHHHhccCCCEEEeecccCCCccccC---------------CHHHHHHHHHhccHHHccchh Confidence 99877999999999888888899999999999999999866432 367999999999999999999 Q NP_000282.1 168 TAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFL 245 (417) Q Consensus 168 ~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~tfl 245 (417) ++||.|||+++++ +| ++||++|++|+++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+|||+|| T Consensus 148 ~~HR~hAS~vgi~~~lp-s~aG~ll~kEl~~L~~~l~~p~rP~v~IlGGaKv~dKi~~i~~ll~~~d~iligG~~a~tfL 226 (394) T 1PHP_A 148 AAHRAHASTEGIAHYLP-AVAGFLMEKELEVLGKALSNPDRPFTAIIGGAKVKDKIGVIDNLLEKVDNLIIGGGLAYTFV 226 (394) T ss_dssp GTTSCCTTTTGGGGTSC-EEECHHHHHHHHHHHHHHHSCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEECTTHHHHHH T ss_pred HhccccchhhhHHhhhh-hhhcHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHhhcCeEEEcchHHHHHH Confidence 9999999999999 67 89999999999999999999999999999999999999999999998999999999999999 Q NP_000282.1 246 KVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYA 325 (417) Q Consensus 246 ~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~~~~ 325 (417) +|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+.+..++.. ...+.+.+|++|+++||||+|++.|+ T Consensus 227 ~a~-g~~iG~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~~DIGp~Ti~~~~ 304 (394) T 1PHP_A 227 KAL-GHDVGKSLLEEDKIELAKSFMEKAKEKGVRFYMPVDVVVADRFANDANT-KVVPIDAIPADWSALDIGPKTRELYR 304 (394) T ss_dssp HHT-TCCCTTSCCCGGGHHHHHHHHHHHHHHTCEEECCSEEEEESSSSTTSCE-EEEEGGGCCTTCEEEEECHHHHHHHH T ss_pred HHh-CCCCCcccccHhHHHHHHHHHHHHHHcCCEEEceeeEEEeccccccCCc-eEeecCcCCCCcccccCCHHHHHHHH Confidence 998 8999999999999999999999988899999999999998865322211 11122478899999999999999999 Q NP_000282.1 326 EAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEG 405 (417) Q Consensus 326 ~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~L~G 405 (417) ++|++|||||||||||+||.++|++||+++++++++++ ++++|+|||||+++++++++.++++||||||||+||||+| T Consensus 305 ~~i~~aktI~wnGP~G~~E~~~f~~GT~~i~~~i~~~~--~a~~viGGGdT~~~~~~~~~~~~~~~vStgGGA~Le~L~G 382 (394) T 1PHP_A 305 DVIRESKLVVWNGPMGVFEMDAFAHGTKAIAEALAEAL--DTYSVIGGGDSAAAVEKFGLADKMDHISTGGGASLEFMEG 382 (394) T ss_dssp HHHHTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHCT--TCEEEECSHHHHHHHHHTTCGGGSSEECSCTHHHHHHHTT T ss_pred HHHHhCCEEEEeCCCCccccchhchHHHHHHHHHHHhc--CCcEEEechHHHHHHHHcCCCccCeEEecchhHHHHHHcC Confidence 99999999999999999998889999999999997632 7899999999998888888877899999999999999999 Q NP_000282.1 406 KVLPGVDALSN 416 (417) Q Consensus 406 ~~LPgl~aL~~ 416 (417) +.||||++|++ T Consensus 383 ~~LPgl~aL~~ 393 (394) T 1PHP_A 383 KQLPGVVALED 393 (394) T ss_dssp CCCHHHHTSCB T ss_pred CCCChhHHhhc Confidence 99999999975 No 9 >1VPE_A PHOSPHOGLYCERATE KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER; TRANSFERASE, PHOSPHOGLYCERATE KINASE, THERMOTOGA MARITIMA; HET: 3PG, ANP; 2.0A {Thermotoga maritima} SCOP: c.86.1.1 Probab=100.00 E-value=1.1e-110 Score=848.42 Aligned_cols=392 Identities=49% Similarity=0.875 Sum_probs=356.6 Template_Neff=6.500 Q NP_000282.1 6 KLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVEL 85 (417) Q Consensus 6 ~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L 85 (417) |+++++.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++. ++.+||+||+++| T Consensus 2 ~~~l~~~~l~gK~vl~R~D~NVP~~~~~i~dd~Ri~~~lpTI~~Ll~~ga-~vil~sHlGrP~g~~-~~~~Sl~~v~~~L 79 (398) T 1VPE_A 2 KMTIRDVDLKGKRVIMRVDFNVPVKDGVVQDDTRIRAALPTIKYALEQGA-KVILLSHLGRPKGEP-SPEFSLAPVAKRL 79 (398) T ss_dssp BCBGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCSSC-CGGGCSHHHHHHH T ss_pred CccccccccCCCEEEEEeeCCcccCCCccCCcHHHHHHHHHHHHHHHCCC-cEEEEeccCCCCCCC-CcccCHHHHHHHH Confidence 56777788999999999999999988899999999999999999999999 599999999998764 4689999999999 Q NP_000282.1 86 KSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDA 165 (417) Q Consensus 86 ~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDA 165 (417) +++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++ +.+|++.||+++|+||||| T Consensus 80 ~~~l~~~V~f~~~~~g~~~~~~i~~~~~g~i~lLENlRf~~~E~~n---------------~~~fa~~La~l~DiyVnDA 144 (398) T 1VPE_A 80 SELLGKEVKFVPAVVGDEVKKAVEELKEGEVLLLENTRFHPGETKN---------------DPELAKFWASLADIHVNDA 144 (398) T ss_dssp HHHHTSCCEEESCSSSHHHHHHHHTCCTTEEEEECCGGGSTHHHHT---------------CHHHHHHHHTTCSEEEECC T ss_pred HHHhCCceeecCCccCHHHHHHHHHhhCCCEEEeeccccCCccccC---------------CHHHHHHHHhcccceeecc Confidence 9999877999999999888888889999999999999999876422 3679999999999999999 Q NP_000282.1 166 FGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFT 243 (417) Q Consensus 166 Fg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~t 243 (417) |+++||.|||+++++ +| ++||++|++|+++|.+++++|+||+++|+||+|++||+++|++|++++|.|++||+||++ T Consensus 145 F~~~HR~~aS~vgi~~~lp-s~aG~l~~kEl~~L~~~~~~p~~P~v~IlGGaKv~dKi~~i~~ll~k~d~iligG~la~t 223 (398) T 1VPE_A 145 FGTAHRAHASNVGIAQFIP-SVAGFLMEKEIKFLSKVTYNPEKPYVVVLGGAKVSDKIGVITNLMEKADRILIGGAMMFT 223 (398) T ss_dssp GGGTTSCCTTTTGGGGTSC-EEECHHHHHHHHHHHHHHHCCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEECTTTHHH T ss_pred hhcCCCCcccchHHHhhch-HhhHHHHHHHHHHHHHHhcCCCCCEEEEEcCCCHHHHHHHHHHHHHHCCEEEECchHHHH Confidence 999999999999998 66 899999999999999999999999999999999999999999999988999999999999 Q NP_000282.1 244 FLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKK 323 (417) Q Consensus 244 fl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~~ 323 (417) ||+|+ |+++|+|++|++..+.|++++++|++++++|+||+|++|.+++..+.....+...+.+|++|+++||||+|++. T Consensus 224 fl~a~-g~~vG~S~~e~~~~~~a~~il~~a~~~~~kI~lP~D~vv~~~~~~~~~~~~~~~~~~ip~~~~i~DIGp~Ti~~ 302 (398) T 1VPE_A 224 FLKAL-GKEVGSSRVEEDKIDLAKELVEKAKEKGVEIVLPVDAVIAQKIEPGVEKKVVRIDDGIPEGWMGLDIGPETIEL 302 (398) T ss_dssp HHHHT-SCCCTTSCCCGGGHHHHHHHHHHHHHTTCEEECCSEEEEESSCSTTCCCEEEETTTCCCTTCEEEEECHHHHHH T ss_pred HHHHh-CCCccCCcccHHHHHHHHHHHHHHHHcCCEEEceeeeEeccCCCCCCcceEEecccCCCCCcccCCCCHHHHHH Confidence 99998 88999999999999999999999989999999999999998653322111111123788899999999999999 Q NP_000282.1 324 YAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELL 403 (417) Q Consensus 324 ~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~L 403 (417) |.++|++|||||||||||+||+++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+|||| T Consensus 303 ~~~~I~~aktI~wnGP~G~~E~e~f~~GT~~i~~ai~~~~~~~a~sivGGGdT~~~~~~~g~~~~~s~vStgGGA~Le~L 382 (398) T 1VPE_A 303 FKQKLSDAKTVVWNGPMGVFEIDDFAEGTKQVALAIAALTEKGAITVVGGGDSAAAVNKFGLEDKFSHVSTGGGASLEFL 382 (398) T ss_dssp HHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHTTCEEEEESHHHHHHHHHTTCGGGSSEEESCHHHHHHHH T ss_pred HHHHHhcCCEEEEeCCCCcccCcccchhHHHHHHHHHHhhhCCcEEEEcchHHHHHHHHcCCCCcceEEEcchHHHHHHH Confidence 99999999999999999999887899999999999976322478999999999998888888788999999999999999 Q NP_000282.1 404 EGKVLPGVDALSN 416 (417) Q Consensus 404 ~G~~LPgl~aL~~ 416 (417) +|++||||++|++ T Consensus 383 ~G~~LPgl~aL~~ 395 (398) T 1VPE_A 383 EGKELPGIASMRI 395 (398) T ss_dssp TSSCCHHHHTSCB T ss_pred cCCCCCcHHHhhh Confidence 9999999999975 No 10 >4FEY_A Phosphoglycerate kinase (E.C.2.7.2.3); Structural Genomics, NIAID, National Institute; HET: ADP; 2.3A {Francisella tularensis subsp. tularensis} Probab=100.00 E-value=5.5e-110 Score=841.97 Aligned_cols=388 Identities=44% Similarity=0.740 Sum_probs=352.5 Template_Neff=6.400 Q NP_000282.1 2 SLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPV 81 (417) Q Consensus 2 ~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~v 81 (417) .||++++++|.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+|| T Consensus 2 ~~~~~~~l~~~~l~gK~vl~RvD~NVPl~~~~i~dd~RI~~~lpTI~~Ll~~ga-~vvl~sHlGrP~~~~~~~~~Sl~pv 80 (395) T 4FEY_A 2 NAMSFLTLKDVDLKDKKVLVRVDFNVPVKDGKVTSKVRIEAAIPTIQYILDQGG-AVILMSHLGRPTEGEYDSQFSLEPV 80 (395) T ss_dssp --CCSCBGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHTHHHHHHHHHHTC-EEEEECCCSCCCTTSCCGGGCSHHH T ss_pred CcccccccccccCCCCEEEEEeeCCCcccCCccCCcHHHHHHHHHHHHHHHCCC-EEEEEeecCCCCCCCCCcccCHHHH Confidence 478899999999999999999999999988899999999999999999999999 5999999999987522458999999 Q NP_000282.1 82 AVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVY 161 (417) Q Consensus 82 a~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Diy 161 (417) +++|+++|+.+|.|+++|++. .++++|+|+||||+|||++|+++ +.+|+++||+++|+| T Consensus 81 a~~L~~~l~~~v~f~~d~~~~------~~~~~g~illLENlRf~~~E~~~---------------~~~fa~~La~l~Diy 139 (395) T 4FEY_A 81 AKALSEIINKPVKFAKDWLDG------VDVKAGEIVMCENVRFNSGEKKS---------------TDDLSKKIASLGDVF 139 (395) T ss_dssp HHHHHHHHCSCEEEESSTTTC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSEE T ss_pred HHHHHHHhCCceeecccccCC------CCCCCCeEEEEecccccCcccCC---------------chHHHHHHHhcchHh Confidence 999999998779999999884 27889999999999999876421 367999999999999 Q NP_000282.1 162 VNDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGG 239 (417) Q Consensus 162 VNDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~ 239 (417) |||||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+ T Consensus 140 VnDAF~~~HR~~aS~vgi~~~lp~s~aG~l~~kEl~~L~~~~~~p~~P~v~IlGGaKv~dKi~~i~~Ll~~~d~iligG~ 219 (395) T 4FEY_A 140 VMDAFATAHRAQASTYGVAKYIPVACAGILLTNEIQALEKALKSPKKPMAAIVGGSKVSTKLSVLNNLLDKVEILIVGGG 219 (395) T ss_dssp EECCGGGTTSCCCCCCCHHHHSSEEEECHHHHHHHHHHHHHHTSCCSSEEEEEEESCHHHHHHHHHHHTTTCSEEEEEEH T ss_pred hhhcHhHcchhccccccccccCCcchHhHHHHHHHHHHHHHHhCCCCCeEEEECCCcHHHHHHHHHHHHHhCCEEEeccH Confidence 9999999999999999998 66689999999999999999999999999999999999999999999999999999999 Q NP_000282.1 240 MAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPE 319 (417) Q Consensus 240 ~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~ 319 (417) ||++||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+++..+.... ......+|++|+++||||+ T Consensus 220 ~a~tfl~a~-g~~vg~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~~v~~~~~~~~~~~-~~~~~~ip~~~~~~DIGp~ 297 (395) T 4FEY_A 220 IANTFIKAE-GFDVGNSLYEQDLVAEATEILAKAKALGVNIPVPVDVRVAKEFSENAQAI-IKKVSDVVADEMILDIGPE 297 (395) T ss_dssp HHHHHHHHT-TCCCTTCCCCGGGHHHHHHHHHHHHHTTCBCCCCSEEEEESSSSTTCCCE-EEEGGGCCTTCEEEEECHH T ss_pred HHHHHHHHc-CCccCCcccchhHHHHHHHHHHHHHHhCCceeeeeeEEecccccccccce-EeeHHHCCCCcEeccCCHH Confidence 999999998 88999999999889999999999999999999999999998754322211 1112478899999999999 Q NP_000282.1 320 SSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGAS 399 (417) Q Consensus 320 Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~ 399 (417) |++.|.+.|++|||||||||||+||.++|++||+++++++++. ++++|+|||||+++++++|+.++++||||||||+ T Consensus 298 Ti~~~~~~i~~aktI~wnGP~G~~E~~~f~~GT~~i~~aia~~---~a~~ivGGGdT~~~~~~~g~~~~~s~vStgGGA~ 374 (395) T 4FEY_A 298 SQKIIAELLKSANTILWNGPVGVFEFDNFAEGTKALSLAIAQS---HAFSVAGGGDTIAAIEKFGIKDQVSYISTAGGAF 374 (395) T ss_dssp HHHHHHHHHHHCSEEEEECCSSCTTSGGGCHHHHHHHHHHHHH---CSEEEEESHHHHHHHHHTTCSTTSSEEECCSHHH T ss_pred HHHHHHHHHHhCCEEEEcCCCCcccccccChHHHHHHHHHHhC---CCcEEEechHHHHHHHHcCCCcCcEEEEcchHHH Confidence 9999999999999999999999998888999999999999762 6899999999998888889888999999999999 Q NP_000282.1 400 LELLEGKVLPGVDALSN 416 (417) Q Consensus 400 Le~L~G~~LPgl~aL~~ 416 (417) ||||+|+.||||++|++ T Consensus 375 Le~L~G~~LPgleaL~~ 391 (395) T 4FEY_A 375 LEFLEGKKLPAIEILKE 391 (395) T ss_dssp HHHHTTCCCHHHHHHHH T ss_pred HHHHcCCCCchHHHHHH Confidence 99999999999999975 No 11 >1V6S_B Phosphoglycerate kinase (E.C.2.7.2.3); phosphoglycerate kinase, Thermus thermophilus, RIKEN; HET: GOL; 1.5A {Thermus thermophilus} SCOP: c.86.1.1 Probab=100.00 E-value=1.2e-109 Score=838.81 Aligned_cols=386 Identities=44% Similarity=0.774 Sum_probs=350.7 Template_Neff=6.500 Q NP_000282.1 7 LTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELK 86 (417) Q Consensus 7 ~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L~ 86 (417) ++++|.|++|||||||+|+|||+++++|.|++||++++|||+||++ ++++|||+||+|||+++ ++.+||+||+++|+ T Consensus 2 ~~l~d~~l~gK~vl~R~D~NVPi~~~~i~d~~RI~~~lpTI~~Ll~-~~~~vvl~sHlGrP~~~--~~~~Sl~pva~~L~ 78 (390) T 1V6S_B 2 RTLLDLDPKGKRVLVRVDYNVPVQDGKVQDETRILESLPTLRHLLA-GGASLVLLSHLGRPKGP--DPKYSLAPVGEALR 78 (390) T ss_dssp CBGGGCCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHH-TTCEEEEECCCSCCSSC--CGGGCSHHHHHHHH T ss_pred CCccccCCCCCEEEEEeeccccccCCccCCcHHHHhHHHHHHHHHh-CCCeEEEEeccCCCCCC--CcccchHHHHHHHH Confidence 5677788999999999999999998899999999999999999999 54359999999999865 35799999999999 Q NP_000282.1 87 SLLGKDVLFLKDCVG-PEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDA 165 (417) Q Consensus 87 ~~l~~~v~f~~~~~~-~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDA 165 (417) ++|+. |.|++++++ +++.+.++.+++|+|+||||+|||++|+++ +.+|+++||+++|+||||| T Consensus 79 ~~l~~-v~f~~~~~~~~~~~~~i~~~~~g~i~lLENlRf~~~E~~n---------------~~~fa~~La~l~DiyVNDA 142 (390) T 1V6S_B 79 AHLPE-ARFAPFPPGSEEARREAEALRPGEVLLLENVRFEPGEEKN---------------DPELSARYARLGEAFVLDA 142 (390) T ss_dssp TTCTT-EEECCSCTTSHHHHHHHHTCCTTCEEECCCGGGSTTTTTT---------------CHHHHHHHGGGCSEEEECC T ss_pred HHCCC-cEeCCCCCCcHHHHHHHHHcCCCCEEEEeccCCCCCcccC---------------CHHHHHHHHhhcceEeeec Confidence 99986 899998888 677778889999999999999999866422 3679999999999999999 Q NP_000282.1 166 FGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFT 243 (417) Q Consensus 166 Fg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~t 243 (417) ||++||.|||+++++ +| ++||++|++|+++|++++++|+||+++|+||+|++||+++|++|++++|.|++||+|||+ T Consensus 143 F~~~HR~hAS~vgi~~~lp-s~aG~ll~kEl~~L~~~l~~p~~P~v~IlGGaKv~dKi~~i~~Ll~~~D~IligG~~a~t 221 (390) T 1V6S_B 143 FGSAHRAHASVVGVARLLP-AYAGFLMEKEVRALSRLLKDPERPYAVVLGGAKVSDKIGVIESLLPRIDRLLIGGAMAFT 221 (390) T ss_dssp GGGTTSCCCCCCCGGGTSC-EEECHHHHHHHHHHHHTTSCCCSSEEEEECCSCGGGTHHHHHHHGGGCSEEEECSTHHHH T ss_pred hhhcCcccchhhHHHhhHH-hhccHHHHHHHHHHHHHHcCCCCCEEEEEcCCCHHHHHHHHHHHHHHCCEEEEcchHHHH Confidence 999999999999999 67 899999999999999999999999999999999999999999999988999999999999 Q NP_000282.1 244 FLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKK 323 (417) Q Consensus 244 fl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~~ 323 (417) ||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+.+...... ...+...+|++|+++||||+|++. T Consensus 222 fL~a~-g~~ig~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~vv~~~~~~~~~~-~~~~~~~ip~~~~~~DIGp~Ti~~ 299 (390) T 1V6S_B 222 FLKAL-GGEVGRSLVEEDRLDLAKDLLGRAEALGVRVYLPEDVVAAERIEAGVET-RVFPARAIPVPYMGLDIGPKTREA 299 (390) T ss_dssp HHHHT-TCBCTTCCCCGGGHHHHHHHHHHHHHTTCEEECCSEEEEESSCCTTCCC-EEEETTBCCTTCEEEEECHHHHHH T ss_pred HHHHc-CCCccccccchhHHHHHHHHHHHHHHhCCeEEceeceeeccccccCCce-EEecCccCCCCcccccCCHHHHHH Confidence 99998 8899999999999999999999888899999999999998865322111 112224788899999999999999 Q NP_000282.1 324 YAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELL 403 (417) Q Consensus 324 ~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~L 403 (417) |+++|++|||||||||||+||+++|++||+++++++++++ ++++|+|||||+++++++|+.++++||||||||+|||| T Consensus 300 ~~~~i~~aktI~wnGp~G~~E~~~f~~GT~~i~~~i~~~~--~a~~iiGGGdT~~~~~~~g~~~~~~~vStgGGA~L~~L 377 (390) T 1V6S_B 300 FARALEGARTVFWNGPMGVFEVPPFDEGTLAVGQAIAALE--GAFTVVGGGDSVAAVNRLGLKERFGHVSTGGGASLEFL 377 (390) T ss_dssp HHHHHTTCSEEEEESCSSCTTSTTTTHHHHHHHHHHHHCS--SCEEEEESHHHHHHHHHTTCGGGSSEECCSSSCHHHHH T ss_pred HHHHHhcCCEEEEeCCCcccCCCCcchHHHHHHHHHHHcc--CCEEEEeCHHHHHHHHHcCCCCcceEEecchHHHHHHH Confidence 9999999999999999999988889999999999997632 78999999999999999898889999999999999999 Q NP_000282.1 404 EGKVLPGVDALSN 416 (417) Q Consensus 404 ~G~~LPgl~aL~~ 416 (417) +|+.||||++|++ T Consensus 378 ~g~~LPgl~aL~~ 390 (390) T 1V6S_B 378 EKGTLPGLEVLEG 390 (390) T ss_dssp HHSCCHHHHTTCC T ss_pred hcCCCCcchhccC Confidence 9999999999974 No 12 >3ZLB_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); TRANSFERASE; HET: ANP, GOL; 1.78A {STREPTOCOCCUS PNEUMONIAE} Probab=100.00 E-value=1.6e-109 Score=839.96 Aligned_cols=394 Identities=46% Similarity=0.789 Sum_probs=353.2 Template_Neff=6.500 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |++++++|.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vlvR~D~NVPi~~~~i~dd~RI~~~lpTI~~Ll~~ga-kvil~sHlGRP~g~~~~~~~Sl~pva~ 79 (398) T 3ZLB_A 1 MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGG-RAILFSHLGRVKEESDKAGKSLAPVAA 79 (398) T ss_dssp CCBCBGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCSGGGSTTCCSHHHHH T ss_pred CCccccccccCCCCEEEEEeeCCCccCCCCcCCChHHHHHHHHHHHHHHCCC-eEEEEeecCccCCcccccCcchHHHHH Confidence 4677888888999999999999999998899999999999999999999999 599999999998753134799999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGD-VYV 162 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~D-iyV 162 (417) +|+++|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|... +. .++.+|+++||+++| +|| T Consensus 80 ~L~~~l~~~v~f~~~~~g~~~~~~i~~~~~g~i~lLENlRf~~~E~~~-e~----------~n~~~fa~~La~l~d~iyV 148 (398) T 3ZLB_A 80 DLAAKLGQDVVFPGVTRGAELEAAINALEDGQVLLVENTRYEDVDGKK-ES----------KNDPELGKYWASLGDGIFV 148 (398) T ss_dssp HHHHHHTSCEECCSCSSSHHHHHHHHTCCTTCEEECCCGGGGGTTTCT-TT----------TTCHHHHHHHHHTSSSEEE T ss_pred HHHHHhCCceeCCCCCCCHHHHHHHHhccCCCEEEEecccccCCCCCc-cc----------cccHHHHHHHHhcCCcEEE Confidence 999999877999999999888888899999999999999999865211 10 114789999999988 999 Q NP_000282.1 163 NDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGM 240 (417) Q Consensus 163 NDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~ 240 (417) ||||+++||.|||+++++ +|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|++++|.|++||+| T Consensus 149 NDAF~~~HR~hAS~vgi~~~lp~s~aG~ll~kEl~~L~~~l~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~iligG~~ 228 (398) T 3ZLB_A 149 NDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGM 228 (398) T ss_dssp ECCGGGTTSCCCCCCCHHTTSSEEEECHHHHHHHCCCCCHHHSCCSSEEEEECSSCSTTTHHHHHHHHHHCSEEEECTTH T ss_pred ecchhhcccccchhhhhhHhhchHhHHHHHHHHHHHHHHHHHCCCCCEEEEEcCCCHHHHHHHHHHHHHHhCceEeCchH Confidence 999999999999999999 666899999999999999999999999999999999999999999999988999999999 Q NP_000282.1 241 AFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPES 320 (417) Q Consensus 241 a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~T 320 (417) ||+||+|+ |+++|+|++|++..+.|++++++ ++++|++|+|++|.+.+...... ...+...+|++|+++||||+| T Consensus 229 a~tfL~a~-g~~ig~S~~e~~~~~~a~~ll~~---~~~ki~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~~DIGp~T 303 (398) T 3ZLB_A 229 TYTFYKAQ-GIEIGNSLVEEDKLDVAKALLEK---ANGKLILPVDSKEANAFAGYTEV-RDTEGEAVSEGFLGLDIGPKS 303 (398) T ss_dssp HHHHHHHT-TCCCTTCCCCGGGHHHHHHHHHH---STTCEECCSCEEEESSSSSCSCE-EECSSSCCCTTCEEEEECHHH T ss_pred HHHHHHHc-CCcccCcccccchHHHHHHHHHH---cCCceEeeccchhhhcccCCCce-eeeccccccCCCeeecCCHHH Confidence 99999998 88999999999888999999875 47899999999998864332111 111124788899999999999 Q NP_000282.1 321 SKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASL 400 (417) Q Consensus 321 i~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~L 400 (417) ++.|.+.|++|||||||||||+||.++|++||+++++++++++ ++++|+|||||+++++++|+.++|+||||||||+| T Consensus 304 i~~~~~~I~~aktI~wnGP~G~~E~~~f~~GT~~i~~~i~~~~--~a~~iiGGGdT~~~~~~~g~~~~~s~vStgGGA~L 381 (398) T 3ZLB_A 304 IAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQP--GVKSIIGGGDSAAAAINLGRADKFSWISTGGGASM 381 (398) T ss_dssp HHHHHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHTST--TCEEEECCHHHHHHHHHTTCGGGSSEECCCTHHHH T ss_pred HHHHHHHHhcCCEEEEeCCCCccCCccccchHHHHHHHHHcCC--CCcEEEecccHHHHHHHcCCCCCCeEEEcchHHHH Confidence 9999999999999999999999998889999999999997632 78999999999988888888778999999999999 Q NP_000282.1 401 ELLEGKVLPGVDALSN 416 (417) Q Consensus 401 e~L~G~~LPgl~aL~~ 416 (417) |||+|+.||||++|++ T Consensus 382 e~L~G~~LPgl~aL~~ 397 (398) T 3ZLB_A 382 ELLEGKVLPGLAALTE 397 (398) T ss_dssp HHHTTCCCHHHHTSCB T ss_pred HHHcCCCCchHHHhhc Confidence 9999999999999975 No 13 >4EHJ_A Phosphoglycerate kinase (E.C.2.7.2.3); Structural Genomics, Center for Structural; HET: MSE; 2.71A {Francisella tularensis subsp. tularensis} Probab=100.00 E-value=2e-109 Score=837.07 Aligned_cols=386 Identities=44% Similarity=0.744 Sum_probs=350.7 Template_Neff=6.400 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |++++++|.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vl~R~D~NVpl~~~~i~dd~RI~~~lpTI~~Ll~~ga-~vvl~sHlGrP~~~~~~~~~Sl~pva~ 79 (392) T 4EHJ_A 1 MSFLTLKDVDLKDKKVLVRVDFNVPVKDGKVTSKVRIEAAIPTIQYILDQGG-AVILMSHLGRPTEGEYDSQFSLEPVAK 79 (392) T ss_dssp -CCCBGGGSCCTTCEEEEECCCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCTTCCCGGGCSHHHHH T ss_pred CCccccccccCCCCEEEEEeeCCCcccCCccCCcHHHHHHHHHHHHHHHCCC-eEEEEeecCCCCCCCCCcccCHHHHHH Confidence 4578888888999999999999999988899999999999999999999999 699999999998752245899999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVN 163 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVN 163 (417) +|+++|+.+|.|+++|++. .++++|+|+||||+|||++|+++ +.+|+++||+++|+||| T Consensus 80 ~L~~~l~~~v~f~~d~~~~------~~~~~g~illLENlRf~~~E~~~---------------~~~fa~~La~~~DiyVn 138 (392) T 4EHJ_A 80 ALSEIINKPVKFAKDWLDG------VDVKAGEIVMCENVRFNSGEKKS---------------TDDLSKKIASLGDVFVM 138 (392) T ss_dssp HHHHHHTSCEEEETTCTTC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSEEEE T ss_pred HHHHHhCCceeecccccCC------CCCCCCeEEEEecccccCcccCC---------------chHHHHHHHhcchHhhh Confidence 9999998779999999885 27889999999999999876421 36799999999999999 Q NP_000282.1 164 DAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 164 DAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) |||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|+++||.|++||+|| T Consensus 139 DAF~~~HR~~aS~vgi~~~lp~s~aG~l~~kEl~~L~~~~~~p~~P~v~IiGGaKv~dKi~~i~~Ll~~~D~IligG~~a 218 (392) T 4EHJ_A 139 DAFATAHRAQASTYGVAKYIPVACAGILLTNEIQALEKALKSPKKPMAAIVGGSKVSTKLSVLNNLLDKVEILIVGGGIA 218 (392) T ss_dssp CCGGGTTSCCCCCCCHHHHSSEEEECHHHHHHHHHHHHHHTSCCSSEEEEEECSCHHHHHHHHHHHTTTCSEEEEETHHH T ss_pred hcHhHccccccccccccccCCcchHhHHHHHHHHHHHHHHhCCCCCEEEEECCCcHHHHHHHHHHHHHhCCEEEeccHHH Confidence 99999999999999999 6668999999999999999999999999999999999999999999999999999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) ++||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+++..+.... ......+|++|+++||||+|+ T Consensus 219 ~tfl~a~-g~~vg~s~~e~~~~~~a~~il~~a~~~~~kI~lP~D~~v~~~~~~~~~~~-~~~~~~i~~~~~~~DIGp~T~ 296 (392) T 4EHJ_A 219 NTFIKAE-GFDVGNSLYEQDLVAEATEILAKAKALGVNIPVPVDVRVAKEFSENAQAI-IKKVSDVVADEMILDIGPESQ 296 (392) T ss_dssp HHHHHHT-TCCCTTCSCCGGGHHHHHHHHHHHHHHTCBCCCCSEEEEESSCSTTCCCE-EEEGGGCCTTCEEEEECHHHH T ss_pred HHHHHHc-CCccCCcccchhHHHHHHHHHHHHHHhCCceeeeeeEEecccccccccce-EeeHHHCCCCcEeccCCHHHH Confidence 9999998 88999999999888999999999988999999999999998754322211 111247888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|++.|++|||||||||||+||.++|++||+++++++++. ++++|+|||||+++++++|+.++++||||||||+|| T Consensus 297 ~~~~~~i~~aktI~wnGp~G~~E~~~f~~GT~~i~~ai~~~---~a~~vvGGGdT~~~~~~~g~~~~~~~vStgGGA~Le 373 (392) T 4EHJ_A 297 KIIAELLKSANTILWNGPVGVFEFDNFAEGTKALSLAIAQS---HAFSVAGGGDTIAAIEKFGIKDQVSYISTAGGAFLE 373 (392) T ss_dssp HHHHHHHHHCSEEEEECCSSCTTSGGGCHHHHHHHHHHHHC---CSEEEECSHHHHHHHHHHTCGGGSSEECCCSHHHHH T ss_pred HHHHHHHHhCCEEEEcCCCCcccccccChHHHHHHHHHHhC---CCcEEEechHHHHHHHHcCCCcCcEEEEcchHHHHH Confidence 99999999999999999999998888999999999999762 689999999999888888988899999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|+.||||++|++ T Consensus 374 ~L~G~~LPgl~aL~~ 388 (392) T 4EHJ_A 374 FLEGKKLPAIEILKE 388 (392) T ss_dssp HHTTCCCHHHHHHHH T ss_pred HHcCCCCchHHHHHH Confidence 999999999999975 No 14 >16PK_A 3-PHOSPHOGLYCERATE KINASE, 1,1,5,5-TETRAFLUOROPHOSPHOPENTYLPHOSPHONIC ACID ADENYLATE; KINASE, PHOSPHOGLYCERATE, TERNARY COMPLEX, GLYCOLYSIS; HET: EPE, BIS; 1.6A {Trypanosoma brucei} SCOP: c.86.1.1 Probab=100.00 E-value=4.2e-109 Score=840.30 Aligned_cols=395 Identities=47% Similarity=0.803 Sum_probs=351.6 Template_Neff=6.400 Q NP_000282.1 6 KLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPM------------- 72 (417) Q Consensus 6 ~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~------------- 72 (417) ++++++.|++|||||||+|+|||+++++|.|++||++++|||+||++ +|++|||+||+|||+++.. T Consensus 2 ~~~l~~~~l~gK~vlvR~D~NVPl~~~~i~dd~RI~~~lpTI~~Ll~-~~~kvil~sHlGRP~g~~~~~~~~~~~~~~~~ 80 (415) T 16PK_A 2 KKSINECDLKGKKVLIRVDFNVPVKNGKITNDYRIRSALPTLKKVLT-EGGSCVLMSHLGRPKGIPMAQAGKIRSTGGVP 80 (415) T ss_dssp BCBGGGSCCTTCEEEEEECCCCCEETTEESCCHHHHHHHHHHHHHHH-TTCEEEEECCCSCCCCBCGGGHHHHHHTTCCT T ss_pred CCccchhhcCCCEEEEEeeCCCcccCCccCCcHHHHHHHHHHHHHHH-cCCeEEEEeecCCCCCCChhhccccccCCCCC Confidence 56777788999999999999999987899999999999999999999 5545999999999986320 Q NP_000282.1 73 --PDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAF 150 (417) Q Consensus 73 --~~~~Sl~~va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~f 150 (417) .+.+||+||+++|+++|+.+|.|+++|+| +.+.++.+++|+|+||||+|||++|++++ + +++.+| T Consensus 81 ~~~~~~Sl~pva~~L~~~l~~~V~f~~~~~~--~~~~i~~~~~g~i~lLENlRF~~~E~~~~-~----------~~~~~f 147 (415) T 16PK_A 81 GFQQKATLKPVAKRLSELLLRPVTFAPDCLN--AADVVSKMSPGDVVLLENVRFYKEEGSKK-A----------KDREAM 147 (415) T ss_dssp TCCGGGCSHHHHHHHHHHHTSCCEEESCTTS--CHHHHHTCCTTCEEEECCGGGBGGGGCSS-H----------HHHHHH T ss_pred CcchhccHHHHHHHHHHHhCCcceeCCCcCC--HHHHHHhCCCCCEEEEecccccccccccc-c----------ccHHHH Confidence 12689999999999999867999999998 45567799999999999999998765221 0 113789 Q NP_000282.1 151 RASLSKLGDVYVNDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNML 228 (417) Q Consensus 151 a~~LA~l~DiyVNDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll 228 (417) +++||+++|+|||||||++||.|||+++++ +|+++||++|++||++|.+++++|+||+++|+||+|++||+++|++|+ T Consensus 148 a~~La~l~DiyVNDAF~~~HR~hAS~vgi~~~lp~s~aG~ll~kEl~~L~~~~~~p~rP~v~IlGGaKv~dKi~~i~~Ll 227 (415) T 16PK_A 148 AKILASYGDVYISDAFGTAHRDSATMTGIPKILGNGAAGYLMEKEISYFAKVLGNPPRPLVAIVGGAKVSDKIQLLDNML 227 (415) T ss_dssp HHHHHTTCSEEEEECGGGTTSCCCCCCCHHHHHTCCEECHHHHHHHHHHHHHHSCCCSSEEEEECSSCSGGGHHHHHHHG T ss_pred HHHHHhccCeEEeechhhcccCcchhccHhHhhcccchHHHHHHHHHHHHHHHcCCCCCeEEEEcCCCHHHHHHHHHHHH Confidence 999999999999999999999999999999 665899999999999999999999999999999999999999999999 Q NP_000282.1 229 DKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIP 308 (417) Q Consensus 229 ~~~D~iligG~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~ 308 (417) +++|.|+|||+|||+||+|+ |+++|+|++|++..+.|++++++|+.++++|++|+|++|.+++...... ...+.+.+| T Consensus 228 ~~~D~IligG~~a~tfl~a~-g~~vG~s~~e~~~~~~a~~ll~~a~~~~~kI~lP~D~~v~~~~~~~~~~-~~~~~~~i~ 305 (415) T 16PK_A 228 QRIDYLLIGGAMAYTFLKAQ-GYSIGKSKCEESKLEFARSLLKKAEDRKVQVILPIDHVCHTEFKAVDSP-LITEDQNIP 305 (415) T ss_dssp GGCSEEEECTTHHHHHHHHH-TCCCTTCCCCGGGHHHHHHHHHHHHHTTCEEECCSSEEEESSSSCCSSC-EECSSSCCC T ss_pred HHcCEEEeCchHHHHHHHHc-CCcccccccchhHHHHHHHHHHHHHhcCCEEEceeceeeccccCCCCCC-ceeccccCC Confidence 98899999999999999998 8999999999999999999999888899999999999999875321111 111224788 Q NP_000282.1 309 AGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKAT-SRGCITIIGGGDTATCCAKWNTED 387 (417) Q Consensus 309 ~~~~~~DIGp~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~-~~~~~~ivGGGdT~~~~~~~g~~~ 387 (417) ++|+++||||+|++.|++.|++|||||||||||+||+++|++||+++++++++++ .+++++|+|||||+++++++|+.+ T Consensus 306 ~~~~~~DIGp~Ti~~~~~~i~~aktI~wnGp~G~~E~~~f~~GT~~i~~~l~~~~~~~~a~~vvGGGdT~~~~~~~~~~~ 385 (415) T 16PK_A 306 EGHMALDIGPKTIEKYVQTIGKCKSAIWNGPMGVFEMVPYSKGTFAIAKAMGRGTHEHGLMSIIGGGDSASAAELSGEAK 385 (415) T ss_dssp TTCEEEEECHHHHHHHHHHHTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHHHCCEEEECSHHHHHHHHHTTCTT T ss_pred CCCcccccCHHHHHHHHHHHHcCCEEEEeCCCccccCCccccchHHHHHHHHhhcccCCceEEEcchhHHHHHHHhCCcc Confidence 8999999999999999999999999999999999998889999999999997632 247899999999998888888888 Q NP_000282.1 388 KVSHVSTGGGASLELLEGKVLPGVDALSN 416 (417) Q Consensus 388 ~~~~vStgGgA~Le~L~G~~LPgl~aL~~ 416 (417) +++||||||||+||||+|++||||++|++ T Consensus 386 ~~s~vStgGGA~Le~L~Gk~LPgl~aL~~ 414 (415) T 16PK_A 386 RMSHVSTGGGASLELLEGKTLPGVTVLDD 414 (415) T ss_dssp TSSEECSCHHHHHHHHTTCCCHHHHTSCB T ss_pred cCeEEEcchHHHHHHHcCCCCCchHhccc Confidence 89999999999999999999999999975 No 15 >3OZ7_B Phosphoglycerate kinase (E.C.2.7.2.3); Phosphoglycerate kinase, Transferase, ATP Binding; HET: SO4; 2.7A {Plasmodium falciparum} Probab=100.00 E-value=4.5e-109 Score=840.55 Aligned_cols=413 Identities=61% Similarity=0.995 Sum_probs=361.2 Template_Neff=6.400 Q NP_000282.1 3 LSNKLTLDKL-DVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPV 81 (417) Q Consensus 3 ~~~~~~i~~~-~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~v 81 (417) ...++++.+. |++||+||||+|+|||+++++|.|++||++++|||+||+++||++|||+||+|||+++. ++.+||+|| T Consensus 4 ~~~~~~~~~~~~l~gk~vlvR~D~NVPi~~~~i~d~~Ri~~~lpTI~~Ll~~gak~vvl~sHlGRP~g~~-~~~~Sl~~v 82 (417) T 3OZ7_B 4 LGNKLSISDLKDIKNKKVLVRVDFNVPIENGIIKDTNRITATLPTINHLKKEGASKIILISHCGRPDGLR-NEKYTLKPV 82 (417) T ss_dssp TTSCCBGGGCCCCTTCEEEEEECCCCCEETTEESCCHHHHTTHHHHHHHHHTTCSEEEEECCCSCCTTSC-CGGGCCSHH T ss_pred CCCCCChhhhhhcCCCEEEEEEeCCCcccCCccCCChhHHhHHHHHHHHHHcCCCEEEEEeeCCCCCCCC-CcccchHHH Confidence 3567888876 89999999999999999888999999999999999999999994499999999998764 568999999 Q NP_000282.1 82 AVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVY 161 (417) Q Consensus 82 a~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Diy 161 (417) +++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|++++++++.+..+.+.+++.+|++.||+++|+| T Consensus 83 a~~L~~~l~~~v~f~~~~~g~~~~~~i~~~~~g~illLENlRf~~~E~~~~~~a~~~~~~~~~~~~~~fa~~La~~~diy 162 (417) T 3OZ7_B 83 AETLKGLLGEEVLFLNDCVGKEVEDKINAAKENSVILLENLRFHIEEEGKGVDANGNKVKANKEDVEKFQNDLTKLADVF 162 (417) T ss_dssp HHHHHHHHTSCCEEESCSSSHHHHHHHHHSCTTEEEEECCGGGSHHHHSEEECTTSCEEECCHHHHHHHHHHHHTTCSEE T ss_pred HHHHHHHhCCEEEEecccCCHHHHHHHHHccCCCEEEEecccccchhccCCCCCCCCccccCHHhHHHHHHHHhhcCCEE Confidence 99999999877999999999888888899999999999999999977632111000000111112467999999999999 Q NP_000282.1 162 VNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 162 VNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) |||||+++||.|||+++++...++||++|++||++|.+++++|+||+++|+||+|++||+++|++|+++||.|+|||+|| T Consensus 163 VnDAF~~~HR~~ASv~gi~~~~~~aG~l~~kEi~~L~~~~~~p~rP~v~IlGG~Kv~dKi~~i~~Ll~~~D~IligG~~a 242 (417) T 3OZ7_B 163 INDAFGTAHRAHSSMVGVKLNVKASGFLMKKELEYFSKALENPQRPLLAILGGAKVSDKIQLIKNLLDKVDRMIIGGGMA 242 (417) T ss_dssp EEECGGGTTSCCHHHHCCCCSEEEECHHHHHHHHHHHHHHSSCCSSEEEEECSSCSGGGHHHHHHHHHHCSEEEECTTHH T ss_pred EecccccCCCCCCchHHHHhcHHhhCHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHHhCCEEEECcHHH Confidence 99999999999999999993228999999999999999999999999999999999999999999999999999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|++++++|+|++|++..+.|++++++|+.++++|++|+|++|.+....++....+...+.+|++|+++||||+|+ T Consensus 243 ~~fl~a~~~~~vg~s~~e~~~~~~a~~il~~a~~~~~ki~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 322 (417) T 3OZ7_B 243 YTFKKVLNNMKIGTSLFDEAGSKIVGEIMEKAKAKNVQIFLPVDFKIADNFDNNANTKFVTDEEGIPDNWMGLDAGPKSI 322 (417) T ss_dssp HHHHHHHHCCCBTTCCCCTTTHHHHHHHHHHHHHTTCEEECCSEEEEESSSSTTSCEEEEETTTCBCTTCEEEEECHHHH T ss_pred HHHHHHHCCCcCCccccchhhHHHHHHHHHHHHHcCCEEEEeeeeeecccCCCCCcCceecCcCCCCCCcccccCCHHHH Confidence 99999984558999999998999999999998889999999999999987533221111222237888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|+++|++|||||||||||+||.++|++||+++++++++++++++++|+|||||+++++++|+.++++||||||||+|| T Consensus 323 ~~~~~~I~~aktI~wnGplG~~E~~~f~~GT~~i~~~l~~~~~~~a~~vvGGGdT~~~~~~~g~~~~~~~vSTgGGA~Le 402 (417) T 3OZ7_B 323 ENYKDVILTSKTVIWNGPQGVFEMPNFAKGSIECLNLVVEVTKKGAITIVGGGDTASLVEQQNKKNEISHVSTGGGASLE 402 (417) T ss_dssp HHHHHHHHTCSEEEEESCSBCTTSGGGCHHHHHHHHHHHHHHHHTCEEEECSHHHHHHHHHHTCGGGSSEECCCSHHHHH T ss_pred HHHHHHHHhCCEEEEeCCCccccCCCcChhHHHHHHHHHHHhcCCCEEEEeChHHHHHHHHcCCCCCcEEEEechHHHHH Confidence 99999999999999999999999888999999999999763224789999999999988888887789999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|++||||++|++ T Consensus 403 ~L~G~~LPgi~aL~~ 417 (417) T 3OZ7_B 403 LLEGKELPGVLALSN 417 (417) T ss_dssp HHTTCCCHHHHTSCC T ss_pred HHcCCCCChhHhhcC Confidence 999999999999974 No 16 >4DG5_A Phosphoglycerate kinase (E.C.2.7.2.3); Bi-lobal protein, Transferase, ATP Synthesis; 2.3A {Staphylococcus aureus} Probab=100.00 E-value=5.2e-109 Score=836.15 Aligned_cols=392 Identities=44% Similarity=0.770 Sum_probs=353.4 Template_Neff=6.300 Q NP_000282.1 5 NKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVE 84 (417) Q Consensus 5 ~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~ 84 (417) .++++.+.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+||+++ T Consensus 9 ~~~~~~~~dl~gK~vlvR~D~NVP~~~~~i~dd~RI~~~lpTI~~L~~~ga-kvvl~sHlGrP~g~~~~~~~Sl~pva~~ 87 (403) T 4DG5_A 9 AKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGG-KIVLFSHLGKVKEESDKAKLTLRPVAED 87 (403) T ss_dssp CBCBGGGSCCTTCEEEEECCCCCCCSSSCCSCTHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCSGGGSGGGCSHHHHHH T ss_pred ccccCCchhcCCCEEEEEeecccccCCCCcCCchHHHHHHHHHHHHHHCCC-EEEEEeccCccCCccchhhcchHHHHHH Confidence 467788889999999999999999998899999999999999999999999 5999999999987522457999999999 Q NP_000282.1 85 LKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVND 164 (417) Q Consensus 85 L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVND 164 (417) |+++|+.+|.|+++|+|+++++.++.+++|+|+||||+|||++|.+. +. +++.+|++.||+++|+|||| T Consensus 88 L~~~l~~~V~f~~d~~g~~~~~~i~~~~~g~illLENlRf~~~E~~~-e~----------~n~~~fa~~LA~l~DiyVND 156 (403) T 4DG5_A 88 LSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKK-ES----------KNDPELGKYWASLGDVFVND 156 (403) T ss_dssp HHHHHTSCCEEESCSSSHHHHHHHHTCCTTCEEEECCGGGGGTTTTT-TT----------TTCHHHHHHHHTTCSEEEEC T ss_pred HHHHcCCeEEecCCcCCHHHHHHHHhccCCCEEEEccccccCCCCCc-cc----------ccCHHHHHHHHhcchHhhhc Confidence 99999877999999999888888899999999999999999865211 10 11478999999999999999 Q NP_000282.1 165 AFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAF 242 (417) Q Consensus 165 AFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a~ 242 (417) |||++||.|||+++++ +| ++||++|++|+++|.+++++|+||+++|+||+|++||+++|++|++++|.|++||+||| T Consensus 157 AF~~~HR~hAS~vgi~~~lp-s~aG~ll~kEl~~L~k~~~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~IligG~lA~ 235 (403) T 4DG5_A 157 AFGTAHREHASNVGISTHLE-TAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAY 235 (403) T ss_dssp CGGGTTSCCCCCCCHHTSSC-EEECHHHHHHCCCCCHHHHSCCSSEEEEECSSCHHHHHHHHHHHTTTCSEEEECSTTHH T ss_pred CHhHccCcCcchHHHHHHHH-HHhhHHHHHHHHHHHHHHhCCCCCEEEEEcCCcHHHHHHHHHHHHHHcCEEEEcchHHH Confidence 9999999999999999 67 89999999999999999999999999999999999999999999998899999999999 Q NP_000282.1 243 TFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSK 322 (417) Q Consensus 243 tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti~ 322 (417) +||+|+ |+++|+|++|++..+.|++++++ ++++|++|+|++|.+.+..++... ..+.+.+|++|+++||||+|++ T Consensus 236 tfL~a~-g~~vg~s~~e~~~~~~a~~ll~~---~~~ki~lP~D~~v~~~~~~~~~~~-~~~~~~i~~~~~~~DIGp~Ti~ 310 (403) T 4DG5_A 236 TFLKAQ-GKEIGISLLEEDKIDFAKDLLEK---HGDKIVLPVDTKVAKEFSNDAKIT-VVPSDSIPADQEGMDIGPNTVK 310 (403) T ss_dssp HHHHHT-TCCCTTSCCCGGGHHHHHHHHHH---STTTEECCSEEEEESSSSTTSCCE-EEEGGGCCTTCEEEEECHHHHH T ss_pred HHHHHc-CCeeeeeecchhhHHHHHHHHHH---ccCceEeeceeeeecccCCCCceE-EecCCCCCCCcccccCCHHHHH Confidence 999998 88999999999888999998873 588999999999998754322211 1122578889999999999999 Q NP_000282.1 323 KYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLEL 402 (417) Q Consensus 323 ~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le~ 402 (417) .|.+.|++|||||||||||+||.++|++||+++++++++++ ++++|+|||||+++++++|+.++++||||||||+||| T Consensus 311 ~~~~~I~~aktI~wnGP~G~~E~e~f~~GT~~i~~aia~~~--~a~~ivGGGdT~~~~~~~g~~~~~~~vStGGGA~Le~ 388 (403) T 4DG5_A 311 LFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLK--DAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEY 388 (403) T ss_dssp HHHHTTTTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHCS--SSEEEECSHHHHHHHHHTTCGGGSSEECSCHHHHHHH T ss_pred HHHHHHhcCCEEEEeCCCccccCccccchHHHHHHHHHhcC--CCEEEEeCchHHHHHHHcCCCCCceEEEechHHHHHH Confidence 99999999999999999999988889999999999997632 7899999999999998889888899999999999999 Q NP_000282.1 403 LEGKVLPGVDALSN 416 (417) Q Consensus 403 L~G~~LPgl~aL~~ 416 (417) |+|+.||||++|++ T Consensus 389 L~Gk~LPgl~aL~~ 402 (403) T 4DG5_A 389 LEGKELPGIKAINN 402 (403) T ss_dssp HTTCCCHHHHTSCB T ss_pred HcCCCCCchHHhhc Confidence 99999999999975 No 17 >6HXE_A Phosphoglycerate kinase (E.C.2.7.2.3); Complex, 3-phosphoglycerate, hinge binding, TRANSFERASE; HET: 3PG; 2.1A {Pseudomonas sp. 'TAC II 18'} Probab=100.00 E-value=4.3e-108 Score=826.14 Aligned_cols=381 Identities=39% Similarity=0.690 Sum_probs=341.5 Template_Neff=6.400 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |.++++++.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++++||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vl~R~D~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~ga-~vil~sHlGrP~g~~~~~~~Sl~~va~ 79 (387) T 6HXE_A 1 MTVLKMTDLDLQGKRVLIREDLNVPVKDGVVTSDARILASLPTIKLALEKGA-AVMVCSHLGRPTEGEFSAENSLKPVAD 79 (387) T ss_dssp -CCCBGGGSCCTTCEEEEECCCCCCEETTEECCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCTTSCCGGGCSHHHHH T ss_pred CCccccchhhcCCCEEEEEeecCccccCCccCCcHHHHhHHHHHHHHHHcCC-cEEEEeecCCCCCCCCChhhcHHHHHH Confidence 3477788888999999999999999998899999999999999999999999 599999999998652245899999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVN 163 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVN 163 (417) +|+++|+.+|.|++++++. ..+++|+|+||||+|||++|+++ +.+|++.||+++|+||| T Consensus 80 ~L~~~l~~~v~f~~d~~~~------~~~~~g~i~lLENlRF~~~E~~n---------------~~~fa~~La~l~DiyVn 138 (387) T 6HXE_A 80 YLSKALGREVPLVSDYLNG------VDVKAGDIVLFENVRFNKGEKKN---------------ADELAKQYAALCDVFVM 138 (387) T ss_dssp HHHHHHTSCCCEESCCTTC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSEEEE T ss_pred HHHHHhCCCCCccccccCC------ccCCCCcEEEEeCccCCCccccC---------------HHHHHHHHHHcccHhhc Confidence 9999998779999865542 27889999999999999876532 36799999999999999 Q NP_000282.1 164 DAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 164 DAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) |||+++||.|||+++++ +|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|++++|.|++||+|| T Consensus 139 DAF~~~HR~haS~vgi~~~l~~s~aG~l~~kEl~~L~~~l~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~iligG~~a 218 (387) T 6HXE_A 139 DAFGTAHRAEGSTHGVAKFAKVAAAGPLLAAELDALGKALGAPAKPMAAIVAGSKVSTKLDVLNSLSQICDLLIVGGGIA 218 (387) T ss_dssp CCGGGTTCCCCCCCCHHHHSSEEEECHHHHHHHHHHHHHHTSCCSSEEEEEEESCTGGGHHHHHHHHTTCSEEEEEHHHH T ss_pred ccHhhcccccCchhhHhhccchhhHHHHHHHHHHHHHHHHcCCCCCeEEEEcCCCHHHHHHHHHHHHHHCCEEEEeChHH Confidence 99999999999999998 6668999999999999999999999999999999999999999999999889999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|+ |+++|+|++|++..+.|+++++ +++|++|+|++|.+.+..++... ......+|++|+++||||+|+ T Consensus 219 ~tfL~a~-g~~vg~S~~e~~~~~~a~~il~-----~~ki~lP~D~vv~~~~~~~~~~~-~~~~~~ip~~~~~~DIGp~Ti 291 (387) T 6HXE_A 219 DTFLAAA-GHPVGKSLYEPDLLDTARAIAA-----KVNVPLPTDVVVAKEFAESAEAT-VKLIADVAADDMILDIGPQTA 291 (387) T ss_dssp HHHHHHT-TCCCCSSCCCGGGHHHHHHHHH-----HSBCCCCSEEEEESCSSTTCCCE-EEEGGGCCTTCEEEEECHHHH T ss_pred HHHHHHc-CCCCCccccChhHHHHHHHHHH-----cCcccccccEEEchhhhccccce-EEehhhcCCCceeecCCHHHH Confidence 9999998 8899999999888888888864 58999999999998754322110 111237888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|+++|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++|+.++++||||||||+|| T Consensus 292 ~~~~~~I~~aktI~wNGP~G~~E~~~f~~GT~~i~~al~~~---~a~~ivGGGdT~~~~~~~g~~~~~s~vSTGGGA~Le 368 (387) T 6HXE_A 292 EHFAQLLKTSKTILWNGPVGVFEFDQFGNGTKVLAKAIADS---AAFSIAGGGDTLAAIDKYGVADQISQISTGGGAFLE 368 (387) T ss_dssp HHHHHHHHHCSEEEEECCSSCTTSGGGCHHHHHHHHHHHHC---SSEEEEESHHHHHHHHHHTCGGGSSEEECCHHHHHH T ss_pred HHHHHHHHcCCeEEEcCCCCccccCccCcHHHHHHHHHHhc---CCeEEEcCHHHHHHHHHhCCCccceEEEcchhHHHH Confidence 99999999999999999999999888999999999999762 689999999999989988988889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|+.||||++|++ T Consensus 369 ~L~G~~LPgl~aL~~ 383 (387) T 6HXE_A 369 FVEGKVLPAVEVLES 383 (387) T ss_dssp HHTTCCCHHHHHHHH T ss_pred HHcCCCCchHHHHHH Confidence 999999999999985 No 18 >4NG4_B Phosphoglycerate kinase (E.C.2.7.2.3); phosphoglycerate kinase, TRANSFERASE; HET: ADP; 2.78A {Coxiella burnetii} Probab=100.00 E-value=4.7e-108 Score=829.99 Aligned_cols=389 Identities=41% Similarity=0.687 Sum_probs=351.1 Template_Neff=6.400 Q NP_000282.1 1 MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEP 80 (417) Q Consensus 1 ~~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~ 80 (417) |+...++++++.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+| T Consensus 9 ~~~~~~~~~~~~~l~gk~vlvR~D~NVp~~~~~i~dd~Ri~~~lpTI~~Ll~~ga-kvvl~sHlGrP~~~~~~~~~Sl~~ 87 (404) T 4NG4_B 9 MKALPFLSMSNLNLHNKRVMIREDLNVPMKNGKITNDERIVRALPTIQKAIEQKA-RVMILSHLGRPEEGKFEKEFSLAP 87 (404) T ss_dssp ----CCCBGGGSCCTTCEEEEEECCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEEECCSCCCTTCCCGGGCSHH T ss_pred ccccccccccccccCCCEEEEEeecCccccCCccCCcHHHHHHHHHHHHHHHCCC-eEEEEeeccCcCCCCCcccccHHH Confidence 5666778887788999999999999999988899999999999999999999999 599999999998753246899999 Q NP_000282.1 81 VAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDV 160 (417) Q Consensus 81 va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Di 160 (417) |+++|+++|+.+|.|+++|++. ..+++|+|+||||+|||++|+.+ +++|+++||+++|+ T Consensus 88 v~~~L~~~l~~~v~fv~d~~~~------~~~~~g~ilLLENlRf~~~E~~~---------------~~~fa~~La~l~Di 146 (404) T 4NG4_B 88 VARLLSKKLNQKVPLINDWLKG------VAVEPGQAILCENVRFNKGENEN---------------NTELAKRMAELCDI 146 (404) T ss_dssp HHHHHHHHTC-CCCEESSGGGC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSE T ss_pred HHHHHHHHhCCCCCcccccccc------ccCCCCCEEEEeccccCCccccc---------------cHHHHHHHHhcccH Confidence 9999999998779999999873 37889999999999999976532 36799999999999 Q NP_000282.1 161 YVNDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGG 238 (417) Q Consensus 161 yVNDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG 238 (417) ||||||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|++++|.|+||| T Consensus 147 yVnDAF~~~HR~~aS~~gi~~~l~~~~aG~l~~kEl~~l~~~~~~p~~P~v~IlGG~Kv~dKi~li~~Ll~~~D~iligG 226 (404) T 4NG4_B 147 FVMDAFATAHRAQASTAGVAAYAKLACAGPLLISEVEALSRALENPQKPLVAVVGGSKVSTKIHLLENLLDKVDQLIVGG 226 (404) T ss_dssp EEECCGGGTTSCCCCCCCHHHHCSEEEECHHHHHHHHHHHHHHHSCCSSEEEEEEESCGGGTHHHHHHHHTTCSEEEEEE T ss_pred hhhcCHhHcccccccccchhhccchhhhhHHHHHHHHHHHHHHhCCCCCEEEEECCCCHHHHHHHHHHHHHhcCeEEEcC Confidence 99999999999999999998 6658999999999999999999999999999999999999999999999999999999 Q NP_000282.1 239 GMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGP 318 (417) Q Consensus 239 ~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp 318 (417) +||++||+|+ |+++|+|++|++..+.|++++++|++++++|++|+|++|.+.+..++.. .......+|++|+++|||| T Consensus 227 ~~a~tFL~a~-g~~ig~S~~e~~~~~~a~~ll~~a~~~~~kI~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~lDIGp 304 (404) T 4NG4_B 227 GIANTFLKAQ-GYSIGKSLCENEWLDAAQQFWEKAAEKNVSLPLPVDVIVADELSEDAKA-TVKNIDAVTSNESIFDVGP 304 (404) T ss_dssp HHHHHHHHHT-TCCCTTCCCCGGGHHHHHHHHHHHHHHTCBCCCCSEEEEESSCSTTSCC-EEEEGGGCCTTCEEEEECH T ss_pred HHHHHHHHHc-CCCcccccccchHHHHHHHHHHHHHHCCCCcCceeEEEEcccCCccccc-EeecccccCCCcccccCCH Confidence 9999999998 8999999999999999999999999999999999999999875433221 1112247888999999999 Q NP_000282.1 319 ESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGA 398 (417) Q Consensus 319 ~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA 398 (417) +|++.|+++|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++++.++++|||||||| T Consensus 305 ~Ti~~~~~~I~~aktI~wnGp~G~~E~~~f~~GT~~i~~~l~~~---~a~sivGGGDT~~~~~~~~~~~~~~~vStgGgA 381 (404) T 4NG4_B 305 NTSATYAKLMAQAGTIVWNGPIGVFEIEAFSQGTRALAQAVAKS---TAYSIVGGGDTLAALDKFNLTDQMSYVSTAGGA 381 (404) T ss_dssp HHHHHHHHHHHHCSEEEEESCSSCTTSSTTCHHHHHHHHHHHHS---CSEEEECCHHHHHHHHHTTCGGGSSEECCCTHH T ss_pred HHHHHHHHHHHhCCEEEEeCCCCcccchhHcHHHHHHHHHHHhC---CCCEEEccHHHHHHHHHCCCCcCceEEecccHH Confidence 99999999999999999999999999888999999999999763 689999999999999989988889999999999 Q NP_000282.1 399 SLELLEGKVLPGVDALSN 416 (417) Q Consensus 399 ~Le~L~G~~LPgl~aL~~ 416 (417) +||||+|++||||++|++ T Consensus 382 ~Le~L~G~~LPgl~aL~~ 399 (404) T 4NG4_B 382 FLEFLEGKILPAIKILTQ 399 (404) T ss_dssp HHHHHHTCCCHHHHHHHH T ss_pred HHHHHcCCCChHHHHHHH Confidence 999999999999999986 No 19 >4NG4_C Phosphoglycerate kinase (E.C.2.7.2.3); phosphoglycerate kinase, TRANSFERASE; HET: ADP; 2.78A {Coxiella burnetii} Probab=100.00 E-value=4.7e-108 Score=829.99 Aligned_cols=389 Identities=41% Similarity=0.687 Sum_probs=348.3 Template_Neff=6.400 Q NP_000282.1 1 MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEP 80 (417) Q Consensus 1 ~~~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~ 80 (417) |+...++++++.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+| T Consensus 9 ~~~~~~~~~~~~~l~gk~vlvR~D~NVp~~~~~i~dd~Ri~~~lpTI~~Ll~~ga-kvvl~sHlGrP~~~~~~~~~Sl~~ 87 (404) T 4NG4_C 9 MKALPFLSMSNLNLHNKRVMIREDLNVPMKNGKITNDERIVRALPTIQKAIEQKA-RVMILSHLGRPEEGKFEKEFSLAP 87 (404) T ss_dssp ----CCCBGGGSCCTTCEEEEEECCCCCEETTEESCCHHHHHHHHHHHHHHHTTC-EEEEEECCSCCCTTCCCGGGCSHH T ss_pred ccccccccccccccCCCEEEEEeecCccccCCccCCcHHHHHHHHHHHHHHHCCC-eEEEEeeccCcCCCCCcccccHHH Confidence 5666778887788999999999999999988899999999999999999999999 599999999998753246899999 Q NP_000282.1 81 VAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDV 160 (417) Q Consensus 81 va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~Di 160 (417) |+++|+++|+.+|.|+++|++. ..+++|+|+||||+|||++|+.+ +++|+++||+++|+ T Consensus 88 v~~~L~~~l~~~v~fv~d~~~~------~~~~~g~ilLLENlRf~~~E~~~---------------~~~fa~~La~l~Di 146 (404) T 4NG4_C 88 VARLLSKKLNQKVPLINDWLKG------VAVEPGQAILCENVRFNKGENEN---------------NTELAKRMAELCDI 146 (404) T ss_dssp HHHHHHHHCC--CCEESSGGGC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSE T ss_pred HHHHHHHHhCCCCCcccccccc------ccCCCCCEEEEeccccCCccccc---------------cHHHHHHHHhcccH Confidence 9999999998779999999873 37889999999999999976532 36799999999999 Q NP_000282.1 161 YVNDAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGG 238 (417) Q Consensus 161 yVNDAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG 238 (417) ||||||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|++++|.|+||| T Consensus 147 yVnDAF~~~HR~~aS~~gi~~~l~~~~aG~l~~kEl~~l~~~~~~p~~P~v~IlGG~Kv~dKi~li~~Ll~~~D~iligG 226 (404) T 4NG4_C 147 FVMDAFATAHRAQASTAGVAAYAKLACAGPLLISEVEALSRALENPQKPLVAVVGGSKVSTKIHLLENLLDKVDQLIVGG 226 (404) T ss_dssp EEECCGGGTTSCCCCCCCHHHHCSEEEECHHHHHHHHHHHHHHHSCCSSEEEEEEESCGGGTHHHHHHHHTTCSEEEEEE T ss_pred hhhcCHhHcccccccccchhhccchhhhhHHHHHHHHHHHHHHhCCCCCEEEEECCCCHHHHHHHHHHHHHhcCeEEEcC Confidence 99999999999999999998 6658999999999999999999999999999999999999999999999999999999 Q NP_000282.1 239 GMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGP 318 (417) Q Consensus 239 ~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp 318 (417) +||++||+|+ |+++|+|++|++..+.|++++++|++++++|++|+|++|.+.+..++.. .......+|++|+++|||| T Consensus 227 ~~a~tFL~a~-g~~ig~S~~e~~~~~~a~~ll~~a~~~~~kI~lP~D~vv~~~~~~~~~~-~~~~~~~i~~~~~~lDIGp 304 (404) T 4NG4_C 227 GIANTFLKAQ-GYSIGKSLCENEWLDAAQQFWEKAAEKNVSLPLPVDVIVADELSEDAKA-TVKNIDAVTSNESIFDVGP 304 (404) T ss_dssp HHHHHHHHHT-TCCCTTCCCCGGGHHHHHHHHHHHHHHTCBCCCCSEEEEESSCSTTSCC-EEEEGGGCCTTCEEEEECH T ss_pred HHHHHHHHHc-CCCcccccccchHHHHHHHHHHHHHHCCCCcCceeEEEEcccCCccccc-EeecccccCCCcccccCCH Confidence 9999999998 8999999999999999999999999999999999999999875433221 1112247888999999999 Q NP_000282.1 319 ESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGA 398 (417) Q Consensus 319 ~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA 398 (417) +|++.|+++|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++++.++++|||||||| T Consensus 305 ~Ti~~~~~~I~~aktI~wnGp~G~~E~~~f~~GT~~i~~~l~~~---~a~sivGGGDT~~~~~~~~~~~~~~~vStgGgA 381 (404) T 4NG4_C 305 NTSATYAKLMAQAGTIVWNGPIGVFEIEAFSQGTRALAQAVAKS---TAYSIVGGGDTLAALDKFNLTDQMSYVSTAGGA 381 (404) T ss_dssp HHHHHHHHHHHHCSEEEEESCSSCTTSSGGGHHHHHHHHHHHHS---CSEEEECCHHHHHHHHHTTCGGGSSEECCCTHH T ss_pred HHHHHHHHHHHhCCEEEEeCCCCcccchhHcHHHHHHHHHHHhC---CCCEEEccHHHHHHHHHCCCCcCceEEecccHH Confidence 99999999999999999999999999888999999999999763 689999999999999989988889999999999 Q NP_000282.1 399 SLELLEGKVLPGVDALSN 416 (417) Q Consensus 399 ~Le~L~G~~LPgl~aL~~ 416 (417) +||||+|++||||++|++ T Consensus 382 ~Le~L~G~~LPgl~aL~~ 399 (404) T 4NG4_C 382 FLEFLEGKILPAIKILTQ 399 (404) T ss_dssp HHHHHHC--CHHHHHHHH T ss_pred HHHHHcCCCChHHHHHHH Confidence 999999999999999986 No 20 >6I06_A Phosphoglycerate kinase (E.C.2.7.2.3); hinge binding, TRANSFERASE, kinase, glycolysis; 2.0A {Pseudomonas} Probab=100.00 E-value=1e-107 Score=823.37 Aligned_cols=381 Identities=39% Similarity=0.687 Sum_probs=326.8 Template_Neff=6.400 Q NP_000282.1 4 SNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAV 83 (417) Q Consensus 4 ~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~ 83 (417) |.++++++.|++|||||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++..++.+||+||++ T Consensus 1 ~~~~~l~~~~l~gK~vlvR~D~NVPl~~~~i~d~~RI~~~lpTI~~L~~~ga-kvil~sHlGrP~g~~~~~~~Sl~~va~ 79 (387) T 6I06_A 1 MTVLKMTDLDLQGKRVLIREDLNVPVKDGVVTSDARILASLPTIKLALEKGA-AVMVCSHLGRPTEGEFSAENSLKPVAD 79 (387) T ss_dssp CCBGG--GSCCTTCEEEEECCCCCCBSSSCBSCCHHHHHHHHHHHHHHHTTC-EEEEECCCSCCCTTSCCGGGCSHHHHH T ss_pred CCCccCChHHcCCCEEEEEeecCcccCCCCCCCcHHHHHHHHHHHHHHHCCC-cEEEEeecCCCCCCCCCcccchHHHHH Confidence 3467777788999999999999999998899999999999999999999999 599999999998652235799999999 Q NP_000282.1 84 ELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVN 163 (417) Q Consensus 84 ~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVN 163 (417) +|+++|+.+|.|+++++.. ..+++|+|+||||+|||++|+++ +.+|++.||+++|+||| T Consensus 80 ~L~~~l~~~v~f~~~~~~~------~~l~~g~illLENlRF~~~E~~n---------------~~~fa~~La~l~DiyVn 138 (387) T 6I06_A 80 YLSKALGREVPLVSDYLNG------VDVKAGDIVLFENVRFNKGEKKN---------------ADELAKQYAALCDVFVM 138 (387) T ss_dssp HHHHHHTSCCCEESCCTTC------CCCCTTCEEEECCGGGSTTTTTT---------------CHHHHHHHHHTCSEEEE T ss_pred HHHHHHCCCceecCCCCCC------ccCCCCcEEEEeCcccCCCcccC---------------CHHHHHHHHhhccHhhc Confidence 9999998778999855442 26889999999999999876532 36799999999999999 Q NP_000282.1 164 DAFGTAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA 241 (417) Q Consensus 164 DAFg~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~iligG~~a 241 (417) |||+++||.|||+++++ +|+++||++|++|+++|++++++|+||+++|+||+|++||+++|++|++++|.|++||+|| T Consensus 139 DAF~~~HR~~aS~vgi~~~lp~s~aG~l~~kEl~~L~~~~~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~iligG~~a 218 (387) T 6I06_A 139 DAFGTAHRAEGSTHGVAKFAKVAAAGPLLAAELDALGKALGAPAKPMAAIVAGSKVSTKLDVLNSLSQICDLLIVGGGIA 218 (387) T ss_dssp CCGGGTTSCCCCCCCHHHHSSEEEECHHHHHHHHHHHHHHSSCCSSEEEEEEESCTGGG--HTCSEE------EEEHHHH T ss_pred ccHhhcccccccccccccCCCchhhhHHHHHHHHHHHHHHhCCCCCEEEEEcCCCHHHHHHHHHHHHHcCCEEEEcChHH Confidence 99999999999999998 6668999999999999999999999999999999999999999999999889999999999 Q NP_000282.1 242 FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS 321 (417) Q Consensus 242 ~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DIGp~Ti 321 (417) |+||+|+ |+++|+|++|++..+.|+++++ +++|++|+|++|.+.+..+.... .....++|++|+++||||+|+ T Consensus 219 ~tfL~a~-g~~vg~S~~e~~~~~~a~~il~-----~~ki~lP~D~vv~~~~~~~~~~~-~~~~~~ip~~~~~~DIGp~Ti 291 (387) T 6I06_A 219 DTFLAAA-GHPVGKSLYEPDLLDTARAIAA-----KVNVPLPTDVVVAKEFAESAEAT-VKLIADVAADDMILDIGPQTA 291 (387) T ss_dssp HHHHHHT-TCCCBSCCCCGGGHHHHHHHHH-----HSBCCCCSEEEEESCSSTTCCCE-ECCTTC-----EEEEECHHHH T ss_pred HHHHHHc-CCcccccccchhHHHHHHHHHh-----cCeEEcccCEEecccCCCCCCcc-eeccccCCCCceeecCCHHHH Confidence 9999998 8889999999888888888764 68999999999998653321110 111237888999999999999 Q NP_000282.1 322 KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 401 (417) Q Consensus 322 ~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgGgA~Le 401 (417) +.|+++|++|||||||||||+||+++|++||+++++++++. ++++|+|||||+++++++|+.++++||||||||+|| T Consensus 292 ~~~~~~I~~aktI~wnGp~G~~E~~~f~~GT~~i~~ai~~~---~a~~ivGGGdT~~~~~~~g~~~~~~~vStgGGA~L~ 368 (387) T 6I06_A 292 EHFAQLLKTSKTILWNGPVGVFEFDQFGNGTKVLAKAIADS---AAFSIAGGGDTLAAIDKYGVADQISYISTGGGAFLE 368 (387) T ss_dssp HHHHHHHHTCSEEEEECCSBCTTSGGGCHHHHHHHHHHHHS---CSEEEEESHHHHHHHHHHTCGGGSSEEECCTHHHHH T ss_pred HHHHHHHHhCCEEEEeCCCChhcCCccchHHHHHHHHHHhC---CCcEEEcCHHHHHHHHHcCCccCcEEEEechHHHHH Confidence 99999999999999999999999888999999999999762 689999999999999988988889999999999999 Q NP_000282.1 402 LLEGKVLPGVDALSN 416 (417) Q Consensus 402 ~L~G~~LPgl~aL~~ 416 (417) ||+|++||||++|++ T Consensus 369 ~L~G~~LPgl~aL~~ 383 (387) T 6I06_A 369 FVEGKVLPAVEVLES 383 (387) T ss_dssp HHTTCCCHHHHHHHH T ss_pred HHcCCCCchHHHHhH Confidence 999999999999975 No 21 >2CUN_A Phosphoglycerate kinase (E.C.2.7.2.3); Phosphoglycerate kinase, Structural Genomics, TANPAKU; HET: 3PG, MPD, GOL; 2.1A {Pyrococcus horikoshii} Probab=100.00 E-value=3.4e-105 Score=811.02 Aligned_cols=387 Identities=33% Similarity=0.531 Sum_probs=341.8 Template_Neff=6.500 Q NP_000282.1 8 TLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKS 87 (417) Q Consensus 8 ~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~~~~~~~Sl~~va~~L~~ 87 (417) +++|.|++||+||||+|+|||+++++|.|++||++++|||+||+++|| +|||+||+|||+++. .+|++||+++|++ T Consensus 3 ~~~~~~l~gK~vlvR~D~Nvpl~~~~i~d~~Ri~~~lpTI~~Ll~~ga-kvvl~sH~GrP~~~~---~~sl~~v~~~L~~ 78 (410) T 2CUN_A 3 RLEDFNFHNKTVFLRVDLNSPMKDGKIISDARFKAVLPTIRYLIESGA-KVVIGTHQGKPYSED---YTTTEEHARVLSE 78 (410) T ss_dssp BGGGSCCTTCEEEEECCCCCCEETTEECCCHHHHHTHHHHHHHHHTTC-EEEEECCCSCTTCTT---CCCSHHHHHHHHH T ss_pred ccccccCCCCEEEEEeeCCCcccCCCCCCcHHHHHHHHHHHHHHHCCC-cEEEEeccCCCCCCC---CCCHHHHHHHHHH Confidence 456678999999999999999998899999999999999999999999 599999999998753 6899999999999 Q NP_000282.1 88 LLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFG 167 (417) Q Consensus 88 ~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~LA~l~DiyVNDAFg 167 (417) +|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|++++++ +++++..|++.||+++|+||||||+ T Consensus 79 ~l~~~v~f~~~~~g~~~~~~i~~~~~g~illLENlRF~~~E~~~~~~--------~~~~~~~fa~~La~l~DiyVnDAF~ 150 (410) T 2CUN_A 79 LLDQHVEYIEDIFGRYAREKIKELKSGEVAILENLRFSAEEVKNKPI--------EECEKTFLVKKLSKVIDYVVNDAFA 150 (410) T ss_dssp HHTSCEEECSCSSSHHHHHHHHTCCTTCEEECSCGGGBTTTTSCCCH--------HHHTTSHHHHHHHTTCSEEEECCGG T ss_pred HHcCcEEehhhccChhHHHHHHHccCCCEEEEeccccchhHhcCCCh--------hHhHHHHHHHHHhccCCEEEecccc Confidence 99877999999999888888899999999999999999977643110 0112356999999999999999999 Q NP_000282.1 168 TAHRAHSSMVGVN--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLD--KVNEMIIGGGMAFT 243 (417) Q Consensus 168 ~aHR~~aS~~gi~--l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~--~~D~iligG~~a~t 243 (417) ++||.|||+++++ +| ++||++|++||++|++++++|+||+++|+||+|++||+++|++|++ +||.|++||+||++ T Consensus 151 ~~HR~~aS~vgi~~~lp-s~aG~l~~kEl~~L~~~~~~p~rP~v~IlGG~KvsdKi~li~~Ll~~~~vD~IligG~~a~~ 229 (410) T 2CUN_A 151 TAHRSQPSLVGFARIKP-MIMGFLMEKEIEALMRAYYSKDSPKIYVLGGAKVEDSLKVVENVLRRERADLVLTGGLVANV 229 (410) T ss_dssp GTTCCCHHHHTTTTTSC-EEECHHHHHHHHHHHHHHTCCCSCEEEEECSSCHHHHHHHHHHHHHTTSCSEEEECHHHHHH T ss_pred cccCCCcchhhHHhhch-HHhcHHHHHHHHHHHHHHhCCCCCcEEEECCCCHHHHHHHHHHHHHHHhCCEEEEchhHHHH Confidence 9999999999998 66 8999999999999999999999999999999999999999999996 78999999999999 Q NP_000282.1 244 FLKVLNNMEIGTSLFDEE-------GAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDC 316 (417) Q Consensus 244 fl~a~~g~~ig~s~~e~~-------~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~~DI 316 (417) ||+|+ |+++|+|++|++ ..+.|+++++. ++++|++|+||+|.++... ...........+|++|+++|| T Consensus 230 fL~a~-g~~ig~s~~e~~~~~~~~~~~~~a~~il~~---~~~~I~lPvD~~v~~~~~~-~~~~~~~~~~~ip~~~~~~DI 304 (410) T 2CUN_A 230 FTLAK-GFDLGRKNVEFMKKKGLLDYVKHAEEILDE---FYPYIRTPVDFAVDYKGER-VEIDLLSENRGLLHQYQIMDI 304 (410) T ss_dssp HHHHH-TCCCCHHHHHHHHTTTGGGGHHHHHHHHHH---HGGGEECCSEEEEEETTEE-EEEESSSGGGGGGGTSCEEEE T ss_pred HHHHc-CCCCCcchHHHhHhhCHHHHHHHHHHHHHH---HCCccccceeEEecCCCCc-ceeeeeccccCCCCCceeecC Confidence 99998 899999987763 34555555542 6889999999999886432 111011122478899999999 Q NP_000282.1 317 GPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGG 396 (417) Q Consensus 317 Gp~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vStgG 396 (417) ||+|++.|+++|++|||||||||||+||+++|++||++++++++++ ++++|+|||||+++++++|+. +++|||||| T Consensus 305 Gp~Ti~~~~~~I~~aktI~wnGP~G~~E~e~f~~GT~~i~~ai~~~---~a~~vvGGGdT~~~~~~~g~~-~~s~vStgG 380 (410) T 2CUN_A 305 GKRTAEKYREILMKARIIVANGPMGVFEREEFAIGTVEVFKAIADS---PAFSVLGGGHSIASIQKYGIT-GITHISTGG 380 (410) T ss_dssp CHHHHHHHHHHHHTCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHS---SSEEEEECGGGGGGGGGSCCC-CCSEECSCS T ss_pred CHHHHHHHHHHHhhCCEEEEeCCCCcccchhhchhHHHHHHHHHcC---CCEEEEecHHHHHHHHHhCCC-CcEEEEecc Confidence 9999999999999999999999999999888999999999999763 689999999999999888875 799999999 Q NP_000282.1 397 GASLELLEGKVLPGVDALSN 416 (417) Q Consensus 397 gA~Le~L~G~~LPgl~aL~~ 416 (417) ||+||||+|+.||||++|++ T Consensus 381 gA~Le~L~G~~LPgl~aL~~ 400 (410) T 2CUN_A 381 GAMLSFFAGEELPVLRALQI 400 (410) T ss_dssp HHHHHHHTTCCCHHHHHHHH T ss_pred hHHHHHHcCCCChHHHHHHH Confidence 99999999999999999975 No 22 >1FW8_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); phosphotransferase, kinase, phosphoglycerate kinase, glycolysis; HET: GOL; 2.3A {Saccharomyces cerevisiae} SCOP: c.86.1.1 Probab=100.00 E-value=8.8e-90 Score=698.26 Aligned_cols=342 Identities=68% Similarity=1.065 Sum_probs=299.2 Template_Neff=6.400 Q NP_000282.1 74 DKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRAS 153 (417) Q Consensus 74 ~~~Sl~~va~~L~~~l~~~v~f~~~~~~~~~~~~~~~l~~g~i~lLENlRf~~~E~~~~~~~~~~~~~~~~~~~~~fa~~ 153 (417) +.+||+||+++|+++|+.+|.|+++|+|+++.+.++.+++|+|+||||+|||++|+++.++ ++.+.+++++++.+|++. T Consensus 2 ~~~Sl~pva~~L~~ll~~~V~f~~d~~g~~~~~~i~~~~~g~IllLENlRF~~~E~~~~~~-n~~~~~~~~~~~~~fa~~ 80 (416) T 1FW8_A 2 SKYSLAPVAKELQSLLGKDVTFLNDCVGPEVEAAVKASAPGSVILLENLRYHIEEEGSRKV-DGQKVKASKEDVQKFRHE 80 (416) T ss_dssp CTTCSHHHHHHHHHHHTSCEEECSCSSSHHHHHHHHTSCTTEEEECCCGGGSHHHHSEEEE-TTEEEECCHHHHHHHHHH T ss_pred CCccHHHHHHHHHHHHCCceeeccCCCCHHHHHHHHhcCCCCEEEEecceecccccccccc-CCcccccCHHHHHHHHHH Confidence 3689999999999999877999999999888888899999999999999999977632100 000001112234789999 Q NP_000282.1 154 LSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNE 233 (417) Q Consensus 154 LA~l~DiyVNDAFg~aHR~~aS~~gi~l~~~~aG~ll~kEl~~l~~~l~~p~rP~v~IiGGaKv~dKi~~i~~Ll~~~D~ 233 (417) ||+++|+|||||||++||.|||++++++|+++||++|++||++|++++++|+||+++|+||+|++||+++|++|+++||. T Consensus 81 La~l~diyVnDAFg~~HR~~aS~vgi~lp~s~aG~ll~kEi~~L~kil~~p~rP~v~IlGGaKv~dKi~~i~~Ll~~~D~ 160 (416) T 1FW8_A 81 LSSLADVYINDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDS 160 (416) T ss_dssp HHTTCSEEEECCGGGTTSCCHHHHCCCCSCEEECHHHHHHHHHHHHHHHSCCSSEEEEEECSCSTTTHHHHHHHHTTCSE T ss_pred HHhhCCeEeecccccCCccccCcccCCCchhhhcHHHHHHHHHHHHHhhCCCCCEEEEEcCCCHHHHHHHHHHHHHhcCE Confidence 99999999999999999999999999976589999999999999999999999999999999999999999999999999 Q NP_000282.1 234 MIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMG 313 (417) Q Consensus 234 iligG~~a~tfl~a~~g~~ig~s~~e~~~~~~a~~il~~a~~~~~~i~lP~D~~v~~~~~~~~~~~~~~~~~~i~~~~~~ 313 (417) |++||+|||+||+|++++++|+|++|++..+.|++++++|+.++++|+||+|++|.+.+..+.....+...+.+|++|++ T Consensus 161 IligG~~a~tfL~a~~~~~iG~S~~e~~~~~~a~~il~~a~~~~~ki~LP~D~vv~~~~~~~~~~~~~~~~~~i~~~~~i 240 (416) T 1FW8_A 161 IIIGGGMAFTFKKVLENTEIGDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADANTKTVTDKEGIPAGWQG 240 (416) T ss_dssp EEEEGGGHHHHHHHHSCCCCCSCCCCHHHHHHHHHHHHHHHHHTCEEECCSEEEEESSSSTTCCEEEEETTTCCCTTCEE T ss_pred EEeCchHHHHHHHHhCCCccCccccchhhhhHHHHHHHHHHHcCCeEEeeeeEEEeccccCCCCCceeeccCCCCCCCcc Confidence 99999999999999755689999999988999999999988999999999999998865322211111122378899999 Q NP_000282.1 314 LDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVS 393 (417) Q Consensus 314 ~DIGp~Ti~~~~~~I~~aktI~WnGp~G~~E~~~f~~GT~~l~~al~~~~~~~~~~ivGGGdT~~~~~~~g~~~~~~~vS 393 (417) +||||+|++.|.+.|++|||||||||||+||.++|++||+++++++++++.+++++|+|||||+++++++|+.++++||| T Consensus 241 lDIGp~Ti~~~~~~I~~aktI~wnGP~G~~E~~~f~~GT~~i~~ai~~~~~~~a~~ivGGGdT~~~~~~~g~~~~~s~vS 320 (416) T 1FW8_A 241 LDNGPESRKLFAATVAKAKTIVWNGPPGVFEFEKFAAGTKALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVS 320 (416) T ss_dssp EEECHHHHHHHHHHHHHCSEEEEESCSSCTTSGGGCHHHHHHHHHHHHHHHTTCEEEECTTHHHHHHHHTTCGGGSSEEC T ss_pred cccCHHHHHHHHHHHHcCCEEEEcCCCCcccccccChHHHHHHHHHHHHhcCCCeEEEechhHHHHHHHhCCCCCceEEe Confidence 99999999999999999999999999999998889999999999997632236899999999999998889878899999 Q NP_000282.1 394 TGGGASLELLEGKVLPGVDALSN 416 (417) Q Consensus 394 tgGgA~Le~L~G~~LPgl~aL~~ 416 (417) |||||+||||+|+.||||++|++ T Consensus 321 TGGGA~Le~L~Gk~LPgieaL~~ 343 (416) T 1FW8_A 321 TGGGASLELLEGKELPGVAFLSE 343 (416) T ss_dssp SCSHHHHHHHTTCCCHHHHTSCS T ss_pred cCchHHHHHHcCCCCCceeehhh Confidence 99999999999999999999985 No 23 >1FW8_A PHOSPHOGLYCERATE KINASE (E.C.2.7.2.3); phosphotransferase, kinase, phosphoglycerate kinase, glycolysis; HET: GOL; 2.3A {Saccharomyces cerevisiae} SCOP: c.86.1.1 Probab=99.28 E-value=3.2e-16 Score=156.69 Aligned_cols=68 Identities=57% Similarity=0.940 Sum_probs=61.4 Template_Neff=6.400 Q NP_000282.1 3 LSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGV 70 (417) Q Consensus 3 ~~~~~~i~~~~l~gK~VlvRvD~NVPl~~~~i~d~~RI~~~lpTI~~Ll~~gak~vil~SHlGRP~g~ 70 (417) ++.++++++.+++|||||||+|+|||+++++|.|++||++++|||+||+++||++||++||+|||+++ T Consensus 347 ~~~~~~~~~~~~~~k~vl~R~D~nvp~~~~~i~d~~Ri~~~~~ti~~l~~~~~~~vii~sH~grp~~~ 414 (416) T 1FW8_A 347 LSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVLEHHPRYVVLASHLGRPNGE 414 (416) T ss_dssp SSCSCBGGGSCCTTCEEEEECCCCCCBSSSSBSCTHHHHHHHHHHHHHHHTCCSEEEEECCCSCCCSS T ss_pred ccccccccccccCCCEEEEEeecCCCCCCCCcCCCHHHHhHHHHHHHHHHcCCCEEEEeeccCCCCCC Confidence 45567777788999999999999999988899999999999999999999998449999999999875 No 24 >2Q33_B D-MONELLIN CHAIN A, D-MONELLIN CHAIN; ALPHA/BETA, ALL-D PROTEIN, DE NOVO; 1.8A {N/A} Probab=34.33 E-value=5.9 Score=24.60 Aligned_cols=11 Identities=36% Similarity=0.761 Sum_probs=9.2 Template_Neff=1.000 Q NP_000282.1 310 GWMGLDCGPES 320 (417) Q Consensus 310 ~~~~~DIGp~T 320 (417) .|.++||||-| T Consensus 2 eweiidigpft 12 (48) T 2Q33_B 2 EWEIIDIGPFT 12 (48) Confidence 58899999955