Mercurial > repos > iuc > artic_minion
changeset 0:c411e2205442 draft
"planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/artic commit 41ad91410844b6d399844b253e39fa29955b96d6"
author | iuc |
---|---|
date | Thu, 30 Apr 2020 04:05:09 -0400 |
parents | |
children | 20165d3a8fb1 |
files | artic_minion.xml test-data/SRR11410539_seqtk_sample_250_1.fastq test-data/SRR11410539_seqtk_sample_250_1.fastq.consensus.fasta test-data/all_fasta.loc test-data/nCoV-2019.V1.bed test-data/nCoV-2019.reference.fasta test-data/nCoV-2019.scheme.V3.bed test-data/primer_scheme_bedfiles.loc tool-data/all_fasta.loc.sample tool-data/primer_scheme_bedfiles.loc.sample tool_data_table_conf.xml.sample tool_data_table_conf.xml.test |
diffstat | 12 files changed, 2588 insertions(+), 0 deletions(-) [+] |
line wrap: on
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/artic_minion.xml Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,110 @@ +<tool id="artic_minion" name="ARTIC minion" version="1.1.0_rc2+galaxy0"> + <description></description> + <requirements> + <requirement type="package" version="1.1.0_rc2">artic</requirement> + </requirements> + <command detect_errors="exit_code"><![CDATA[ + mkdir -p 'scheme/name/version' && + #if str( $primer_scheme_source.primer_scheme_source_selector ) == "tool_data_table": + ln -s '${primer_scheme_source.primer_scheme_bedfile.fields.path}' 'scheme/name/version/name.scheme.bed' && + #else: + ln -s '${primer_scheme_source.primer_scheme_bedfile}' 'scheme/name/version/name.scheme.bed' && + #end if + #if str( $reference_source.reference_source_selector ) == "history": + ln -s '${reference_source.reference}' 'scheme/name/version/name.reference.fasta' && + samtools faidx 'scheme/name/version/name.reference.fasta' && + #else: + ln -s '${reference_source.reference.fields.path}' 'scheme/name/version/name.reference.fasta' && + samtools faidx 'scheme/name/version/name.reference.fasta' && + #end if + artic minion + --threads \${GALAXY_SLOTS:-1} + --normalise '${normalise}' + --read-file '${read_file}' + --scheme-directory 'scheme' + --medaka + $bwa + 'name/version' + '${read_file.element_identifier}' + ]]></command> + <inputs> + <param argument="--read-file" type="data" format="fastq,fastqsanger,fastq.gz,fastqsanger.gz" label="Input Read File"/> + <param argument="--normalise" type="integer" min="1" value="200" max="2000" label="Coverage normalisation depth"/> + <param argument="--bwa" type="boolean" truevalue="--bwa" falsevalue="" label="Use bwa aligner"/> + <conditional name="primer_scheme_source"> + <param name="primer_scheme_source_selector" type="select" label="Select a primer scheme from your history or use one from a tool data table?" + help="Screening files must be stored in the 'primer_scheme_bedfiles' tool data table"> + <option value="tool_data_table">From tool data table</option> + <option value="history">From history</option> + </param> + <when value="tool_data_table"> + <param name="primer_scheme_bedfile" type="select" format="bed" label="Primer Scheme"> + <options from_data_table="primer_scheme_bedfiles"> + <validator type="no_options" message="No primer scheme .bed files are available" /> + </options> + </param> + </when> + <when value="history"> + <param name="primer_scheme_bedfile" type="data" format="bed" label="Primer Scheme" /> + </when> + </conditional> + <conditional name="reference_source"> + <param name="reference_source_selector" type="select" label="Will you select a reference genome from your history or use a built-in reference?" > + <option value="cached">Use a built-in reference</option> + <option value="history">Use a reference from history</option> + </param> + <when value="cached"> + <param name="reference" type="select" label="Using reference genome" help="Select genome from the list"> + <options from_data_table="all_fasta"> + <filter type="sort_by" column="2" /> + <validator type="no_options" message="No references are available" /> + </options> + </param> + </when> + <when value="history"> + <param name="reference" type="data" format="fasta" label="Use the following dataset as the reference sequence" + help="You can upload a FASTA sequence to the history and use it as reference" /> + </when> + </conditional> + </inputs> + <outputs> + <data name="alignment_trimmed" format="bam" from_work_dir="*.trimmed.bam" label="${tool.name} on ${on_string}: trimmed alignment" /> + <data name="variants_tabular" format="tabular" from_work_dir="*.variants.tab" label="${tool.name} on ${on_string}: variants table" /> + <data name="variants_merged_vcf" format="vcf_bgzip" from_work_dir="*.merged.vcf.gz" label="${tool.name} on ${on_string}: variants vcf" /> + <data name="consensus_fasta" format="fasta" from_work_dir="*.consensus.fasta" label="${tool.name} on ${on_string}: consensus sequence" /> + </outputs> + <tests> + <test> + <param name="reference_source_selector" value="history" /> + <param name="read_file" value="SRR11410539_seqtk_sample_250_1.fastq" /> + <param name="reference" value="nCoV-2019.reference.fasta" /> + <param name="primer_scheme_source_selector" value="tool_data_table" /> + <param name="primer_scheme_bedfile" value="test_entry" /> + <output name="consensus_fasta" file="SRR11410539_seqtk_sample_250_1.fastq.consensus.fasta" /> + </test> + <test> + <param name="reference_source_selector" value="history" /> + <param name="read_file" value="SRR11410539_seqtk_sample_250_1.fastq" /> + <param name="reference" value="nCoV-2019.reference.fasta" /> + <param name="primer_scheme_source_selector" value="history" /> + <param name="primer_scheme_bedfile" value="nCoV-2019.V1.bed" /> + <output name="consensus_fasta" file="SRR11410539_seqtk_sample_250_1.fastq.consensus.fasta" /> + </test> + <test> + <param name="reference_source_selector" value="tool_data_table" /> + <param name="read_file" value="SRR11410539_seqtk_sample_250_1.fastq" /> + <param name="reference" value="test_entry" /> + <param name="primer_scheme_source_selector" value="tool_data_table" /> + <param name="primer_scheme_bedfile" value="test_entry" /> + <output name="consensus_fasta" file="SRR11410539_seqtk_sample_250_1.fastq.consensus.fasta" /> + </test> + </tests> + <help><![CDATA[ +This tool aligns MinION reads that were generated from a tiling amplicon library against a viral reference sequence. +It generates a consensus fasta file and a vcf variant file. + +This tool is configured to use the experimental 'medaka' variant caller. + ]]></help> + <citations> + </citations> +</tool>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/SRR11410539_seqtk_sample_250_1.fastq Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,1000 @@ +@SRR11410539.882919 882919/1 +CTTGGGCATTAGTCGTTCAGTTACATGTACTAAGGTTAAACAGACGACTACAAACGGAATCCCGACAGCACCTACCAATAACTTTCAAATCGTAGTCTGTTCTCTAAATATGAACTTTAAAATCTGTGTGGCTGTCATCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCATCTTCTGCAGGCTGCTTACGGTTCGTCCGTGTTGCAGCCGATCCTCTTTATCTAGGTTTGTCGGGTGTGACCGAAGGTAAGATGGAGAGCCTTGTCCCCTGGTTTCAACGAGAAAACACGTCCAGTTTGCCTGTTTTACAGGTTCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGAGTCTTATCAGAGCACGTCAACATCTTAAAGATGAGGGTGCTATTGGTTTTCCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTTT ++ +$0%#%$##'*(&)&&*)0/09711$$$&&/3%%)*3;:<:99:;;992&6;DF;<$&,2%%6/8:64=D@B?>:37//.11%%%%'#%--($&%&)077AB:6A4/0.)'(+.223301344/3%'(*0169<,(3%''$%%,+5//,((,40=,8%$8@>?=/&&15676.0++)1335:<:?<;>9;>=A??6**5<830-%&)4//265/1'59:H@=>3//8:53/-13AE8<A:<:9:?977#%''&&++.0&&)%$%&'*12/05;ABC<4F)/AAAA?=99450*>;;=?B??B@/)+42.28122+*2/4//)<126,,.2,<9:,83$$-&9@<=6;<DA<<H4@@=CCAA3038)%%'74.30+(/++*,.3010-7@A7<@C895.'0:>@>54800+8=<70/6)*>9;EJBDE@0:24&'(4<::3)).,.,/1,&,&*,0C=@<=9?;7>>;77*+,)-),%&*//;>B?<72&'+* +@SRR11410539.1188960 1188960/1 +TATTACTACCATTCGTTCCCATGCCTTACTAAGGTCACTCGACCAACTCTGGCATGAATCGACAGCACGCGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAGCTTTTGGCAATCATCTGGATGCACCCACACCACTAGGCATTGATTTAGATAGTGGAGTATGGCTACATACTACTTGTTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCAGATGAGGATGAAGAAGGTGATTGTGAAGAGAAGTTTGAGCCATCAAACTCAATATGAGTATGTAGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCGCACTTCTGCATCTTCAACTGAAGAGCAAGAAGAAGATTGGTTAGATCGAAGGTGCTGTCAATTCCGTTTGTAGTAATCTGTTTAACCTTAGCAATACGTAACTT ++ +#$#$$#$$%%%%'%&$$%)(%%###$%($%))('('%"$%#$#%#%"'-$"##$&%&*&086)%421$$*%&).6./8<ACFELGBBCACC>;:B@>D2:BF@21&+/?@C=80.B<<B?:<:9=<614)9844<?BABF93;11234'/003+&'*()%#&.9+)+)0%%(***/1632.&&&13>=><1./15-101'*914,6=;?<=>:-.52261+((*'-065280,-.;-58@32?EDA8923<0:552:8;602<;03+.<:=:?3/0(1>?<(780@/4)<?=2'&8,,((2.)''+-,&$5,+$&''-22111<;4-:9:09-7((.-)&*,10%%$%*.&%167B@@EIFMD=79./40459::BA@=*/*0058&&,$$%029;:76'$#//=9://1(++69;36=:'0-,3)4//558=>--.%&&&-).<0.5&))&($'%5499<+&+$$%%.64<9;?970((+</89994@:;00%%( +@SRR11410539.1794060 1794060/1 +CATTTATTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGCAGCATCTACAGCAAAAGCACAGAAAGATAATACAGTTGAATTGGCAGGCACTTCTGTTTGCATTACCAGCTTGTGAACGATGCTGTGGCAGCTAAACTACCAAGTACCATACCTCTATTTAGGTTGTTTTAATCCTTTAATAAAGTATAAATACTTCACTTTAGGACCTTTAGGTGTGTCTGTAACAAACCTACAAGGTGGTTTGATTCTGTATAGATAGTACCAGTTCCATCACTCTTAGGGAATCTGGCCATTTCAAATCATTAAATCGGATAACAGGCACAAGTACAAACCTACCTCCCTTTTGTTGTGTTGTAGTAAGCTAACGCATTGTCATCAGTGCAAGCAGTTTGTGTAGTACCGGCAGCACAAAGACATCTGTCGTAAGGTGCTGTCGATTCCGTTTAATAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +0&&)*&'-'79;9;N+.&<>>6)$.&,0??C:;/ID>;=3?34,7:567>:67*2#&&.9;=D-=*<@DA65-//2=B:;3..-9?IKLCBDIDC@A+%,A?7878408;7:.--0./,*/145<C;D;9:92,,))+7;944$$*'+($$%&%)$#&383436.4)CD>?<;;:()&73767:9224BB?<:846?AC9?;GB7;89;=CEBC:A@ABGCA@C+$$589??>CC@@7@A4756731-/091+6+,4/15>?9<;<A<:;0<436FD:87=/5<:;;758<967>><8;=A;;81+<++??A6-;>;94*>-2877===6<00*&5%&/;>4*<9=;D430&)&$$%)+,.+*)-)@@F5336:?=?BGC?AE:AB=AB3.:=89622--,3B@@BC>>315-1B<A/006/?CCE68>4528<AAAB/+;;53,---32;=>47293200.,437;:8<BA>@:<8724$$(109;99::@?@D<<5;90;&5761>@9/-.)* +@SRR11410539.635976 635976/1 +GTTGTACTTCGTTCGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCACCTCATGGCTGCATCACGGTCAAATTCAGATTGCCACATTCAAGACTTCTTCAACTTTTTAAGAACAACCAGAATCACCATTAGCAACAGCCTGCTCATAAGCTTCTTGAGCAGTAGCAAAAACTGCATATGATGGAAGGGAACTAAACTCTGAGGCTATAGCTTGTAAGGTTGCCCTGTTGTCCAGCATTTCTTCACAAAGCTTGTTTATGTCTACAGCACCCTGCATGGAAAGCAAAACAGAAAGTAGTGAAACCATTTTTCAGGCTTCAGTAGTATCTTTAGCTAAGGAATGTCATTGTGTAACTGGACACATTGAGCCCACAATTTAGATGATGATTCTACTCTGAGTTGTTGCAAAACTGAGAGTAAGACTACTGATGTGCAAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +*$%)35;=@;=H<,*1)9?@EI>I=@?'(5>IHEG93/3/6.+&%#$.269--<9=8:56168==FD>?,232,&%'*.2056<9:8:2+%1+2/'25:?@@:8-.--"#&/26F<?DVTSNB,,(9B?9)$*?767;AD@?99=9<>>?BI>B?A?A8C43/1&()+9HGDD89784447?>>9'3'+DB@CADB?;=,4,;A;A>?;<-?=<9<-4:4:>3-/&&)*8893>GF;93+8>67@))@B;C>?AC@C04,,-.'$$$0:>@CB;@>BC?@>GFEHI@;68:44546>?=AAHI@55=5=><34>@A:==@@>BF>.)*'9>?D;<6D:<FB;<PH?:761/1-($5=@=@=AB??DHAC?A=>=5<-)&(<=A@@8//?A;?EC@DA&&($2/AA57;D??@;DFA<<='7DEEJ?=A6339:?A?AA?EA:EB;36;=23-C?B@B<8?=7717;9B?;:B;?C==A>BEFBA;3121=,7750/B><22$ +@SRR11410539.400371 400371/1 +CATCATTGTACTTCGTTCAGTTACATATTAGCACTAGGTTAAACAGACGACTACAAACCAGATCGACTTGCAGCACCTAGAATAACCTGGTAAGAATGAGTAAACTGGTGTTAAACGAAGTACAGTGAATGACATAAGGAATAGTAAAAGTATTAAGGCAACTACATGACTGTATTCACCAAGCTCTTCAGCCTCTTGAAATAGTGACATGAAACATGTTACTGATAGCTACAATACCAGCTACTATGAATACTGATGTATCCAGCACCAATAGGTTGAATTAGTGGTGTAAACATATTAGTAAAGTAAATTCTCAGCATCTACACCACAGAAAACTCTGGTAAAGATCCACAATAATCATTAGATACCCATCTACTAGTAGATACACAAACACCAACTTCTGATCTTTCACAAAGGTGCCGTGCCTACAGTACTCAGAAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACGCCTTGTGCGTGCTT ++ +'&%%$')+)%567349/.*,(,)'*'(()''(&&*&$;469;1*-+3/0201-/24*&(0%&-+('''(#(+*+1//*('('$&%'')%('-/2;D26/=)*77/.-,>B=9464)#%&&))699CBDF>>=A-97950(+5/135620'734623/33./9@AE;DEC@CB=::7.*()*,2687<2*%&+)1'&)%,1/*-.-$$&'(+((&('%%.+#&')&$*'*///00-,>6D.77<992(%%'$$(*+,/+%$'%&*$*024A<+(/=H@<75<<;9;'+//34927+**,1-3967156'+,-+#'/0,840=300.,&(*('+0+,&&&$$&*-/%*,$$&#'$&%%%38**('$#*'88;@?@8**-+-544=:+'&'',1*%-4)*-1520@?>AFC/+..11%'2A?<??@;90;?.)74/=8:?3761%=8DAA@722/+*74:;ABE;9?><C>:<2688-*+(*0/./$-%'$#$%$% +@SRR11410539.2279751 2279751/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGTATTGCCCTATTTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGAGTGTTTATGATTACTTGGTTTCTACAGGAGTTTAGATATGAATTTGCAGGGATATTTACTCCCACCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACGCAGTCTAAAATGTCAGATGCTGAAGTGCACATCAGTAGTCTTACTCTCAGTTTGCAACAACTCAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAACGTAAC ++ +&&*+/845>=:7F7667BBB;;6769%4<()6?FE@A<7;=>CDKEJ>;=>58'*&8:;7*27898>=715::=>?DBA6;?DJECCEFB;@EB<C<?A@FA>><?G.1(:@<BGFEHADAC=DGGGFED<KM8?:AA><CBA>B@@H<3>=EJBIC:89;8=<=<;5@>GE;CA+><80--./'/8'$58?<;0'9?8?C@D70-:A486<>?=<<?7335('))*&&#%$%%%5=AB9>>80%$'$+-(%(+(..%$$&'&%),&(&((,((349-4%&*3898B:;7>,??@,<=D?@GGNK@BBDI?FG;=BACB@>>@78@AB=;=??99=:?DFG>1=--*$()'%1)9-EE?H?0'5/456-')*''%19>0@-)4*('..88:<37<10,'947C:<?@>99?*/)(15.2/:76=;>=C827448<<=?CH:6:>?AB@55=79AB97&',?C98>3;CBFLD9;9GFKDGDB:;1/<5=:<;11.+*+(05<<6,$ +@SRR11410539.1984739 1984739/1 +CATTAGCTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAACGACAGCACCTAAAGGTGTCTGCAATTCATAGCTCTTTCAGAACGTTCCGTGTACCAAGCAATTTCATGCTCATGTTCACGGCAGCAGTATACACCCCTCTTAGTGTCAATAAAGTCCAGTTGTTCGGACAAAGTGCATGAAGCTACCAGCACGTCTAGAAGGTCTTTAATGCACTCAAGAGGTAGCCATCAGGGCCACAGAAGTTGTTATCGACATAGCGAGTGTATGCCCTCCGTTAAGCTCACGCATGAGTTCACGGGTACACCACTGCTATGTTTAGTGTTCCAGTTTTCTTGAAAATCTTCATAAGGATCAGTGCCAAGCTCGTCGCCTAAGTCAAATGACTTTAGATCGGCGCCGTAACTATGGCCACCAGCTCCTTTATTACCGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +%##%%%&0//14<>N9;5<FG=G>GIDI>>@A@0IPIGJ>?''=6<69?<>35CCAFJH@<.--66875-56$*DC=<=?AA==9<C?CE?BFE@=)5A2<=8>PG;?AFFEB>?;42<:=::JD=??AH6?=A><9,912.2,2&,=A<?>A<368;:5666E=6=,-2374-44EDDGIBICA=A@<FG95B@DB9>64)):=@=98,(($&%+02<6(G;=KHB=?=9ACD:=,./(9:7E?A@>:A==CD@A8;//--C.3=6:A;</%C;3*+,45>@D>?A>76349=BMD349>?B<@CFE@D:JFC*/62/2(*+6<A@@B406A@BCA;6;CDDE.73?8>HF@IBBC:HE9:A@?8955?A@72&-<9<==><@@??=>9623-.(89:<94=6CCK@B99:;11?488<892),2732569:812=>9?>D;111)87=-.7?AAC=6@=<:@:<=GEL@;886<;=?=ABB>HH?>B=433110-,-/&&() +@SRR11410539.607606 607606/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAACAGACGGCAACGGAATCGACAGCACCTTGATTTGAGTGTTGTCAATGCCAGATGCGTGCTAAGCACTATGTGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCCCCAACTAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCAGACATGTTCCTCGGAGACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAAAATGTTTTATAAGGGTGTTATCGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGAGGTGCTGTCGATTCCGTTTGTAGTCAAGTCTGTTTAACATAGCAATAAC ++ +%$'('&&./+,).6/):BB<;75343,29$%).*0(()&-'0%&***+*/)79=EKD?JHC>CIKJFHKF@?HIEBLB?B@D;<B@7@14%.)A;>DKNFG@ACF>=&::=7;>(()57>@BC=DA<786%%%)%%%%.A>>;:=B>:?8:<10&&&114,4*;59?'6<>E>F;,9<>4@?CHF7A@A>2>9@@?FDD>B=565.,*/00.5<<5>?.%,');>A:<?=;>4@=,5%>BGF59A57648<(44:@>=@@>JIDF3@B>8:735*3..8DB>JJF;=BA:=@?A?0.(%%&%9:++<>A44@B02337996:73A6<,-))%%*(+,3375&(7:;870*+()4@=EA1-*.15?@?ED@BD@?A@G@@FCGE987,,+,+76@A=?=?/445)0512/*34;/HDFFE@4B@@BCD@>/140146;<C9>/$0&7=>=DBD>@;93=:<<HG?7*$'$$$%(01/210/513*.2&(0-)&%$ +@SRR11410539.1159044 1159044/1 +CTGTTGTGCTTCGTTCAGTTACGTATTGCTAAGGTAAACAGACGACTACCATGGAATCGACAGCACCTTGGACAGTAAACTACGTCATCAAGCCAAAGACCGTTAAGTGTAGTTGTACACAAGTTACTTGTACCCGCACAACCCTCAACACCAGATGGGAATGCCATTTTCTAAAACCACTCTACCAAAACAGCTGAGGTGATAGAGGTTTGTGGTGATTCTTGGTAAAAGAACATCAGAACCTGAGTTACTGAAGTCATTGAGAGCCTTTGCAGAGATGACAGCAAGCAGCTTCTCTGTAGCTAGTTGTATCATTGCTCCACTAAAATACTTGTACTTATTATAAGGCTAAGTATCTATTATGTTGCGTAAGGGTAATAGCACATCACTACGCAACTTTGAATCATTCTTTATTTAACAAAAAAGGTGCACAGCGCAACTATTTAAAAAGTAGGTGCTGTCGATTCCGTTTGTGATCGTCCTGTTTAACTTATGTAATGCAGCAGC ++ 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+@SRR11410539.1550900 1550900/1 +CAATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAAGGCGACTAAACGGAATCGACAGCACCTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTGATAGCAGACAAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGGCAAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTAAAATTGCTGTCGATTCCGTTTGTAAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +$#%$%-449;<>BI=81>DBGCBCHDH>=>3),:DFDF=>-.,%,(())02.1353;>>;8423)8<?>@337*..57CD8<E;??CD>61.+-47=>.+;=EDB3525@CCFDC9<C@CEEB@@<??BA?C:C<<454(69A$=EJF@**<52/2*+@B.359:29ABBG?>;%%<4<9=<GA?=;/>>*-++,6:EGBA>3:FEDGC-1@;:B33:FIIHFC<79,-(,$)&+((%0978A<=EDE<57::B=@B@4=@?=A@BBBB=:-/)<6854('&&(+;>>9::5*''':;@BGH2@19,6;;9@?C?ABDCAA;=>35>>C2=<B@,@/?A>GKEAB:5888EA67AC<=69-@FAIAFB<>@??E9BACC<64679-<98)$8:CACDA@=D<@=BB@FEFC-?)7,<2/((567('%%'/%#$7:;>67<?<=:;66:;EE>,,375>AA?::A68.(518B64*+&('/4677>BCABFAD<GA>45022>?:66B>>@?FH=A>8:.5660/=:<<=3, +@SRR11410539.1781029 1781029/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTACAGTCAGCTTATGTGTCAACCTATGCTGGTACTAAGATCAAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGGCCTGTAAAAACTCAAAACACTAGTTGCAACTGCAGGAAGCTGAACTTGCAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCAATGACCTTGGTGCTTGTATTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +(,-7=;9<?<>N9>:<@B=@?BB:9*/-$&$8DBDI>>?=FABJABGBEF48(.(==?<==@=C@@=>>;7*2,921'11122335)$9&(77><$$&('%/')/&&2156-.89745959;87<7>::1439;4>8732;258:68?<>4>:@:>FF8B>>GECB?;918BED=JE<<DEF9DAM=BA?E127777743.$&$$%$'$*/11.38698::@8?>B?D>F???ID:366(,,/887::;;=:))$%&)0;<&&-%+ACC?HI>C>?=@DAF@=;==@>:?A/;=8<8;D8:&,6)*39>DHG>>???G>A@<710C:;=<DCBFJ48>B=EB,<<-1589AGKC::GIH=>BB=A>ECA8=9?=C:BE@F>EGEAA@<:B<A?B?>?2,665.02:<731<@BDAFCIBD=?>FF;/-9:9:@AA;>@5/''(((((1/,>A@A>B@A<GJ@A>>@@DCD<69;<BGFGC?A6AAJ<EBB=A73?8B@B>765430'13:966;76/.$% +@SRR11410539.192227 192227/1 +TGTTGTACTTCGTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTCATTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGAAGCTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGGAGAGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAGAGCTATGAATTGCAGACACCTTAGGTGCACACACAGCCGATTCCGGTTTGTAGTCGTCTGTTTAACCTTAGCAAACCACGTAAAC ++ +$%++*-+:?AB@K6:'-79>>7D?AF>?@660?OIFKH8B;AFBEBGEDDF7+%'+6>@=E9E2@F;:A5##$**+04.))'=C@@BC=<::-1,=.0+201@;=<A>9@>GJ?,&2%#$&$'&$111;=FCEH?45)''&134238=>((2(*@>=<9*:@DL>>330>IBD<<:ADE@?A<IKCDG?D7974=;>?FA;13565CGDBAC7>B=424++''''8;@04)*&,1%/2:>:545<8<<<,,>>;=57221$$,$$#&):;95;=;,(0.5+-+*0789;?B@B;DJEIIKDIH/8D?@B?B=?DBE=CHGDE<?ADH6/36:=55:DC=FGI-%?66;<'(8>?A2*-<=<;>?>CCACFI88JA??;@@:4;77*688HJIJ?BEGC?61,,.=FFIA899-234.6.>CFED9LE@;<<C5)>0A=DA@;;8B@?;<>8>7971'0+4()*$&&$%%%#*204:(,$*&)3146531)7<=AC@2..-.,/0$$#$(&'1311*,&( +@SRR11410539.424988 424988/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACAGGAATCGACAGCACCTATCACATAGACAACCAGGTGCGCTCAGGTCCTATTTTCACAAAATACTTCATAGATGTCAACTCAAAGCCATGTGCCCATAAGACAAATACGACTCTGTCAGAGATTTTTAAGTGTGTCACTTAACATTTGTACAATCTTTATACCTTTTCCCATTCCAAGGAAGTCCTTTGTACATAAGTGGTATGAGGTGTTTAAATTGATCTCCAGGCGGTGGTTTAGCACTAACTCTGGAAAAATCTGTATTATTAGGTGTATCAACATAACCTGTAGGTACAGCAACTAGGTTAACACCTGTAGAAAAACCTAGCTGTAAAGGTAAATTGGTACCAACAGTTTCTCTAGTAGCATGACACCCCTCGACATCGAAGCCAACGTCAATACACGTACATGTCTTATAGCTTCTTCGCGGGTGATAAACAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATATATTTT ++ +-***+)452,&6*80453)+)-.:@;ACCC(5;IIIL=?9:?@BA=<=9;9/'$..)6667..1004::2+3==?2/2-24*+$30;/B<<;F;:4>733/+4>;58*,,?A?E<=BGF@5498B4+'A:;=5,9;=3CBE>@=?CCC???ACD?FGE?=<:CAD=>:616(/86CCBA7577HE8B9A<))+BBD?CBG=;F=FG=?JI@70/&+&../$)7:>?&.+)/;34@<>B?EIC@EB=?=?@E=?BC=5285;;=B8,/47;A@=C@$@<G966=C<?KI:2--88:?B=B2?<@4<E?>9A<?B>AE>??@=9BFFB<D66@65%&+*-095:A?A:C59-.87<6@FD>>:<::B=6/.@>09634/'52*44AA/)65)),,/11+5((210+)*29,47)'-//25(/7145>:?<>AAB?852)./$$$$'('%0-,*+)5=DHGD>A?9?81'&%),,2BMIE=>=>@>CDADE@>>>$6=DCCC?:844;A7;<HD=,);86@74C:D>><::42126-0--.'##%%%% +@SRR11410539.1493037 1493037/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAGACAACCAGCACCTACTAGCACTCTCCAGGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAACTTTGTAAGAATAATAATGAGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAACCCATTACTTTATGATCACCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAAGTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTGCCAGAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAATACATGCT ++ +++-$$$4579;B+-&06;=;8<8-0(7;?@)989885+&*&(6;?DFDBC97%*%+)+,-/47483CCBDF@HAB:599?$410;@>C@H9<../1?;::?,622=>EA@D<;9.,//13C12<:;<:II;<:5%/A;2C:<?HKH>>B?;GHA@IBBA789998741::8<:9CH=73;8?<@ED7</*-:;A==;;6.<>?@BD51-,-+>@;010;=F@A9;9DA:%,%%%'+$(89:<2;DKKLA??,-@C@?@<<8<:-7DEA9@?8<=>7966BB850%%#+3%%523*,H<;HHG?>A463)(--/&'&)'$*%/361:78::8;33@CA@6@==2''-')''',1-1/,%('/&13((+-,-535385;;A=<839%%7**)00292441;8?;:2*+.(22(=8B0A<*3B?B><7?CDA?-06<=72/0-1407<11=<2**&*$$23221$$#"$ +@SRR11410539.103412 103412/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGGAATCGACAGCACCTAATTTGGAAGAAGCTTAAGGTATGTAGAATCTCTCAAAGTGCCGGCTACCCAGTTTCTGTTTCTTCACCTGATACTGTTACAGCATTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATGAAAATTTCTTAAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAGAGTGTTTACAACAGTAGACAACATTAACATAC ++ +$*+-;:=?@99I5;79<DFD=GD@A=D@443?AEEHB>=>?C?=;465')&.)46:<B>D;DIECCAB>>D&(?D<A2-(((.-)*)(''$&%'%59>31>GH?;D<<3%)',*&=53<;E?B@>@<F;GB@?DA?;?/'8==@==884.%%)&6:=@588:@;<B>6-.4:A<.@>:,?BHHEC@9111,4<=;?@D-$$'7%1@7/?AB>5//=:66E79@?%&8@=CG9999@9:'')C=<:@>;=;17897:CD;>01;1=,.32,%'&'*37?===*+5(36B@@:GJ>45FCCDBA;604@@;;278:77;><;=?AA@A67>=<D??C@;<A@>@88>A<?J>?<=HGFBEE:<BBHI4(240&6:?<@DF<MICC<103974::9=BB=AC:/;*)9@@??;5500)%8=F@FB..<,,.%$%-'(& +@SRR11410539.2448562 2448562/1 +TGATAGCCGCTACGTTCAGTTACATTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCTTTCTGAACAAAGACCATTAATTACTGGACTAAAACTAAAGTGAAGTCAAAATTGAGTAACAACCAGTGGTGTGTACCCTTGATTGTTCTTTTCACTGCACTTTGAAGAAGTAACACCTAAAGAGCATTTATCTGCTAGCATCAAAAGGTGTAAATTCATCTTCTAATAAAGCACTGCAATATGGTACGTGTTCATACCATTTTGCAGTAATTCTTTTAATGAGCACACATATCTGAACGACATGATTCCAGTTTCAGGCAGAAAAGGTCCTAGTATGTCAACATGGTCTTGTGTTAAGGGTTATAATTGTACTTCATAGCCACAAGGTTAAAGTCATTAAGAGTTGTGGCCAAATCAGTTAATACCTGTCTCCATTTATAACAGCAGCGTACAACCAAGCTAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACAGCGGCTACGTATAAC ++ +&(&('%%%$(6'74?,.&&,,%&$$&%')+2978+?86))%&(('059=@A=<=7*(/+$$&$%($&'''4-89>5;<3/=57024%'$))&&020..379B;:=>09DEA4?:>DE<A0,:+86;;>;<B58*<9>;<<>BB=>44=?:83&19:<BIEAD@GF@A<BD::23(.$,+6883/'-$&$%$(,%%%$%++*$''+%.642<<82(<@?F<@GGI?@;A@0A.>@9:<201+&(->?<1-*+,&#$$*$%&+0**99>AENK;>6<:*+*679753;=5--14.*::AG5.7&'&&%%$$%#$%'1%62=99/$%%%,((.+)&,3'')-**/)$+'?78:9%&.<=CC>=@?<))5(6(&%+&)'//'.345=9>A44334/0(GHF=>.(:;+27/0:6DAB<;*($$245.-%%%+&+,1-/5<<>E9=777/.8<=8758+A:48.348-;;=B>BBC/1>D::;73C<?CA15<?@B5647:=>>B?@<;:,(('$%$%###+())(##$ +@SRR11410539.1987503 1987503/1 +CAGTAATGCTTCGTTCAGTTACACAAGGTTAAACAGACGACTACAAGCGAATCGACAGCGCACCTTGGTGAACAGTCATGTAGTTGCCTTTAATACTTTTACTATTTCACTTATGTCATTCACTGTACTCTGTTTATTTCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTGACATTTTATCTTACTAATGATGTTTCTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCGTTTTCATTGTTCTTTAGTATTACCTAAGAGACGTGTAGTCTTCCAATGGTGTTTCCTTTAGTACTTGAAGAAACACTGTGTTTACCTTTTTATTAGAAATAAAAATGTATCTAAAGTTGCGTAGTGATGTGCTAGGTGTTTGTCGATTCCAGTTTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +-&*(%%(&01475HD/&)412025000?CA>>,=<=>>A94-*+,-*-%$(.2540%2&4<?>>8899-9''%#(.09;<:5?=,2456>:<@8955?A<-,-''((7'%),;11/3599<33.($$$:;>:>9-)$&%)'5-0706;5;;:=<5>@AF;>?EDF=FE@>;65*57;=73632.(&3;>@B<=JEA=@@:62/4899;I@GDB8;76@8:;=C@FDEDDB48=;<BB:<BA89::9+*2::=@BA?;<:97247579:?>BC=CB<?;;AHFGD<>;@>C6C;66?/2/.::.),&))+-%%*,'&)&,/,0(-)*-4773*,%0;>><A@2-88:B@01686*0;=<;F;;89;99;:,,/54204.''#"&$)$'(()+,,---*)-.1%,20/>?6)?58B:7<;56''-=>GF:>9@>44-2''+/,0.-+,+1974.20%'$'$)+&3990*</BAAB===?<;;7:>=2?>;:0.' +@SRR11410539.1032430 1032430/1 +CAATGTACTTCGTTCAATTGACGTTCGCTAAGTTCAAACAGACGACTACAACGGAATCGACAGCACACTCAGCAACTGTTTGTGGACCTAAAAGAAAGTCTGCCTAATTTGGTTAAAAACTCAGAATGTGTATTAATTATTTTCAATGGTTTAACGAGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCTTTCCCAACAATTTGTAGAACATTGCCTGACACTACTGATCAACATCTTGATCCACAGACACTTGAGATTCTTGACATTTACACCCTTGTTCTTTAATTTAGTGTCAATTATATTTTCAGGAACAAATGCACTAGCAGGTTGCTGTTCTTTATCGGGGTGTTAGCTGCACAGGGGGTCCTAGCTATTCGGCGGATCAACTTACTCCACCCAGCGTATTTATTCATACGGGTTCTAAAAGCAAACAGGCATTGCAGGCTGTTTAATAGGGGCTGAGGTGCAATGCGATTTCGTTTTTGTAGTCGTCTGTTTAACCCAGCGCAATACATAAC ++ ++%&##%(*-209C=7%&%%%$,(.-$#$)'''(-%&++32438++)'%%)).,//4982.&$++*-'$(,$*+''&03243'%489.-+@C:'$&&$)%11'(%%366=6*+6<,,*-3685...=$$)%$$%)%%+.&%&%*(8;B;=DG>113(('%#$%+-C:E=@@=330212,<,::8==61/5??<89*$&'*,..''46646*(%14+--.,0%0&2356588:;4++%$''%%(&(.;<78A12117-477;;89@ED?PB?::<:;?:=10/%&(29:650+,-*..)(@727$'#)+()'('&+%1=9B>:;8''(00*("%$%6;;&'939959?=73<%*6/.0*+'(()&%%$(&*((/..1*'$*51><4$()%'&22**++('(3/*&'''./&)0-:;:::7(&%%4%.>61*$()(($$%'&*,%*2001<97@>;@DGG@56737:BB@87-*4C<<55+)77357$($+-,(('%,.9;:669:;<1&&$(&&#$$'01,('$&''' +@SRR11410539.49493 49493/1 +CGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTGTTTTACAGGTTCGCGACAGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGATATTATCAGAGGCACGTCAACATCTTAAATTGGCACTTGGCGGGCTTAGTAGAAGTTGAAAAAAAGGCGTTTTGCCTCAACTAGACAGCCCTATGTGTTCATCAAACGCGTTCGGATGTGAACTGCACCTCGTGGTCATATTCATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGGAGACACTTGGTGTCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTGCGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTGCGGG ++ +$%%%%%'$$%/$#(&(./,20/4?><BC-DFDAD672436?@970846)1&+.889BB>:BBD<=C?CD?@H>=*BEIFF>5,/%(&'22;9+*/)72B4<>?BA98<5;>=3=A>77,2'+$%$$..33/2(.0=9)?2/A45=2=CC<'(''./4==<==1-&,047799>:D;@6@B>78A=7.'%&28CJBBC@C@<A.,'$$%-+*+:;:9:7:BBDDF92EDE>7&8:A);-.;3&$%&#%&'--4403%',/,7*$%()$58<?:CE@KCC=>15+($&'6<;>97?AA??A:?9?@DHBA7<44546,.4+'70(77844>,&1*:9=>B?;8>;>7DCHB**>C<<C1+1;;>78:>@?(<63+AEA>JA6BBC<A=?3KDD79BAEAHI-=99)BBAADBDA;42..&,%8.0<>>;74230:<11<C224@G?>@BDFB8B42/-/33368?@@=55&&.&$%$&% +@SRR11410539.844846 844846/1 +CAGTATTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTAAACAGGAATCGACAGCACCTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCCCTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGAGGTTTAAATGGTTACACTGTAGAGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGGAACCTTAGCCATCCCGCTA ++ 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+GTTGTACTTCGTTCAGTTACGTATTACTAGGTTAAACAGACTGACTACAAGCAAATCGACAGCACCTTGTGTGTACAAAAGCTGCCATATTGCAACAAGATTTGCTGCATTAGTTAGTCACCACAAATGTACATTGTACAATCTACTGATGTCTTGGTCATAGACACTGGTAGAATTTCTGTGGTAACACTAATAGTAAAATTTGTGGGTATGGCAATAGAGTTATTAAGTAAAGCAACTGAATTTTCTGCACCAAGTGACATAGTGTAGGCAATGATGGATTGACTAGCCACACTACGTGCCCGCCGAGGAGAATTAGTCTGAGTCTGATAACTAGCGCATATACCTGCACCAATGGATATGCACTCATATGAGTTGGTGACATGTTCAGCCCTATTAAACAGCCTGCGTGTTTGAGGTGCCGCATCGTTCCGTTTGTAGTCGTCTATTTGGCCTTAACCAATGTAACT ++ +%/12:;;?A;;E?:69<@=>8930/+952.(DB<><2./+'%2.-3&'14$;:;6/3.175>CF<=?=+*%'/0-37:9,%6:BAB=877>-;*)5(*%$%,-$&(%*%''%,-/$%+)&&&.079:8;:>C=>B:<=8:;77=5ADDFF;>A>9%%)$,3,+A;C>@@A3=(@:::B>;55-/0)))0./9:7.>@DI7CCEJ@@9<B@@G?@D>A>;:=??9:13$$&,)+&#%&&%6995PLJFG:85343&();<9:137/712,-.4..4544-0(00-(%+1&)'$)&'&%%&)&158=>>B>3.7,<>:<6<3>16/6.<(3-)+*&(,-:>?<5;2388:994<=10,(*&%%*&'.:@=:65,%#,94(*/.-6677>=9;485+'((,?@<7:/()()+8A@>B<;---,&%&$,*'*%')'.19>E<>3459572%%))(#$#%$'''$'#%%$%(%%( +@SRR11410539.2448953 2448953/1 +CATTGTACTTCGTTCCCCAGCGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTGGAATTTGGTGCCACTTCTGCTAACTCTTCAACCTGAAGAAGAGCAGAAGAAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTACAATGCGAACATTGTGGAAGAAACTAAAAGGTAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAATACGGCTGTAATGCCATGCAAGT ++ +$%'(*(/++,',/2'(''$'-22203226000AIGJMD>56:<:7;:6875)5%)&'.<;D=C<D9A@D;>A8@CE8;C>@@,)<;8924:**87??@C;<GEGHHG242*1-11,97%6-$/,,3:<HE;<AA//CABEHG>C66DHJCCEB??297<<>=CEF<A7>@9<7727;BDG@72,-0,,.=@<9/3-,*+-1E;=;I=?<33%9;>C..<=4>444449,,77;=8;5BC=<?=CFCHD2:916:AA<5411(-3CHHI@AEGEJ>89%<=MG=>??@B:=>@?7;@@7/;=..&$)$&%$%('.@//0,%-2+-..,$%'440&(0512*'(57,&0,%**+.17?A772;236>?;<B>5**+*+78&,'**/2=2+*9>?25/1,,2%,(+%%&&$$#%$*'%&$$&$&+2%&&$%&, +@SRR11410539.2111921 2111921/1 +CATTGTACTTCCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAGCACCTGAGGTTGCGCTGTGAGGACATAGTCACATGCAAGAAGACACACCATGAGGTGCTGACTGAGGAAGGACATAAGATAGTAGCCCTTTCCACAAAAATCAACTCTTTTGATTGTCCAAGTACACACTCTGACATTTTAGTAGCAGCAAGATTAAGCAGAAGCTCTGATTTCTGCAGCTCTAATTAATTGTTGAGTCACACATGTGTCTGCAAGCTTTGAAGTCTGCCTGTGATCAACCTATCAATTTGCACTTCAGCCTCAACTTTGTCAAGACGTGAAGGATATCATTTAAAACGCGAAATTGCACCAAAATTGGAGCTAAGTTGTTTAACAAGCGTGTTTAAACGTACATTTGGTTGACCACATCTTGAAGTTTTCCAAGTGCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTGCTCTCCCCGTAACA ++ +%$&'$.(**/$%6<6>6?DAC;<@FAA:A=--1>BB;>;:::812'),%%68:1))055374?>@4<<*%#'-%'$'%'-(&'$')&$$%&)('$$2/+,-++*)90%3%?BCE??8=B@BBBFE;791)&+,'05>5;89A;4&&24/00..:E<?DANM=A+%;;<@DHGNLA@<9B89:A;<7D;$>ACE9A7BBADHEM<93A;A;B6@DDEA85-,$'&&)));<7?BBOKI@?=>EAD4?1EGJI6768<>14'82>;(6:1-/+09<?6=79(<=>6:02567A<@@@9;>3.?,,BBE=8<=@=@N@?,9:?.9'??;>+++<<=3)=/0/:817:69*AA5:>;)):?===22$$(*068A9?87>><;,,18:3:>)CDDACAFGB::=ED<>=?A564%'(*&&$1148:26/5@A>AC=:=?D:@5=?<CRK5==<7FE??;?;@B=;7=:;EE<@?C@EAGHD>@>?B=?DFDCE<1+($%).;<;.$&&''' +@SRR11410539.261583 261583/1 +CATTGCCTTCGTTCAGTTGCATGCTAGATTAACGGGCGGCTACAAACAGAATCGACATAGCACTAGCAAATATTGGACTGAGACGGCCTTACTAAAGGACCTCCTTGAAATTTGCTCTCAACATACAATGCTAGTTAAACAGGAGTGATGATTATGTGTACCTTCTTACCCAGATCCATCAAGAATCCTAGGGAGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATGAACAGTTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCTAATCAGGAAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ 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+GTTGTACTTCGTTCAGTTGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACCACAGCGGATGGACTTACCCTCTTGAACAGCATCACCTATATCTAGACATCTTTCTTTAAGAAAGTGATGTCAATGTCACCTAACAAGAGTGGCAGAATCTGGATGAAGATTGCCATTAATGTCAATATAAAGTAACAAGTTTTCTGTGAACTTAGTTTCTTCCAGAGTTGTTGTAACTTCTTCAACACAAGCTTTGATTTTCTTATCATCTTGTTTTCTCTGTTCAACTGAAGGTTTACTTTCCAGTTATAAATAACTTAACTTCCTCTTTAGGAATCTCAGCGATCTTTTGTTCAACTTGCTTTTCACTCTTCATTTCAAAAGCTTGAAACAAGTTTGTCATAGAGATTTTATCAAAGACAGCTAAGTAGACATTTGTGCGAAAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCGCTAGCAATTTGGC ++ +&''%$%%%)(6@+9157*'*&'+7<A23/B:8999@?BC@EEBB@8::66)/388><A.)9::DAH3+)1)*'*%+%&$)4''%(<=CC?<>;;@+E(=72;20*+*$$#%%%-)5;<>;A=9BF=;<4:53.FADE/*804:?=CFF%?ABA;;2./GAECKBBE;>A67<>DA;BCCK<;<>IHBB;<8??CFE@JO62C67B12=16OGEA?998/=BBEDFIMCJB.7F<40=:%9><=333A@;A6?@A>E@BA5BEFFCDEHCC@FEC<:<:<97:58HF<CC=AHID00/23087:?@=;8:;A)0:=HFD?-.%%#$''*:;:A:,-58>;FEGIE@9?0>>>6((8?A@@A=?>>:;22434@AF@@72;AFDDBED+;KP?0D<<;?6AA=@74>?M>9A6.'4''<GIJE72A=>7<CD<<@7FFB@66F>?DEJ5A<4..,$.?A=BC=9;<;E?CD9@=421/9;/+=,?=<6--,2%&)*%*$$#"%#$$ +@SRR11410539.2467772 2467772/1 +GTTGTACTTCGGTTCAGTTACGTATTGCTAAGGTTAAACAAGACGACTACAAACGGAATCGACAGCACCTCATCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAAGTGTCTATATAGTAGGTGATCATTGTTCCAAGAGGGAATGTTTCAACTACTATGAGTTTATACCTACTAAAGGCTGGTGGCACTACTGAAGTACTGGCAAAAAGCTTTGAAAAGTGCCAGCAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAACAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCCTGTCTGTGGAAACTAGGTGCTGTCAGAGATTCCGTTTCAAGTCGTCTGTTTAACTGGCAATACGTAACTT ++ 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+CGGTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGAGAATCGACAGCACCTGGTACCAACAGCTTCTCTAGTAGCATGACACCCCTCGACATCGAAGCCAATCCATGCACGTACATGTCTTATAGCTTCTTCGCGGGTGATAAGCATATTAGGGTAACCATTAACTTGATAATTCATTTTAAAACCCATCATAGAGATGAGTCTTCTATAGGTCATGTCCTTAGGTATGCCAGGTATGTCAACACATAAACCTTCAGTTTTGAATTTAGTGTCAACACTGAGGTGTGTAGGTGCCTGTGTAGGATGTAACCCAGTGATTACCTTACTACAATCTTTAAAGAGTCTGTTACATTTTCAGCTTGCTAAAGTTGCACATTCCTACGTGGAATTTCAAGACTTGTAAATTACAGCTTGTCATAAAGGTCTCTATCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACACTTAGCAATCTATCTTTTA ++ +0%''$$#359=>E:2*-DECBACHCJ=<A51-=HGGIF4?8A<>;>?<312')&*2/899@;61/2;@<?BD?;B@111+6>@?D4;2626<=>=36.43>8<>C@<<83,*&(-?DB@C<?C@<?A=CEFDB5>?9;?>@19*'655=>E0@588:A@611(.+''41,3-3?@@;<=A@>>//0<7735FG?>678:@AE>+,-:<@=><<@CA*BDF=>>AEFD<C9A<?G@@78@9?992<A7787681<?;+$>9::?98:AE>>>>7A>B>ALB=>@DC=(+B94???>D?AD@A@?DCG73:-62=<>78;22=?B@BECACA9+.AB@A>8?;<=7:;?>CC>AAB=CD-1-64<9>G?BBBB?J18-,$&&#"+67/9--#**48>?;<B?77@;=;1@C/.9:61,01**(,--+$($.9;=>>A87AA7/E9:>=:62777*<@=6489?ACC@69=CCIE@CB<=;<?<6:73,+*&#$'&#&%&%%#$%$%%%%# +@SRR11410539.2124668 2124668/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAAAGAGGCCCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAATACTAATGGACCACTTAAAGTGGGTGGTGGTTGTGTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTGCACCATTATTATCAGCTGGTATTTTGGTGCTGACTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAATCTCTATGACAAACTTGTTTCAAGCTTTTGGAAATGAAGAGTGAAAAGGGATTTTTGTCGATTCCATTGCATGATTAATCCTACCTTAGCAATACGTAACT ++ 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+CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCTGGAATCGACAGCACCTCCTACCTCCCTTTGTTGTGTTGTAGTAAGCTAACGCATTGTCATCAGTGCAAGCAGTTTGTGTAGTACCGGCAGCACAAGACATCTGTCGTAGTGCAACAGGACTAAGCTCATTATTCTGTAATTTGACAGCAGAATTGGCCCCCTTAAAGCTGTTACAATAGAGGCCATGCTAAATTAGGTGAATTGTCCATACTAATTTCACTAAGTTGAACAATTTTACTATCTGCATCTACAACCTGTTGGATTTCCCACAATGCTGATGCATAAGTAAATGTTGTACCATCACACGTATTTTATATGTGTTATAGTCTGAGCTATGACAACCATTAGTTTGGCTGCTGTTGTAAGAGGTATTATGTTCAAGGGAACACAACCATCTCTTACCTGGTGTGCTGTCGGTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGC ++ +-/13)3+9:=<<M?;4<;=80(<6CF88=9:3ECBEI=<9<9::78.)&,-%$$$&%/,/2;8>23)44=412<;:;?B..:EBIK?FDEDA=>=@56G;>6650B::<=<=858./=8=7.,0/;<??;9@2(+6==>99,)BD<9ADFB;6=B@B>CBEIEJFC22'%;:@46<=,99A?BD=BB=CB??B>AFDB:8;<@94218(())*,''*?@=9@::CB2ABE+>'.0<>AB@DBDHG-?;66*,6&&&.7569?;?E@<>ABLDFEC>?;@??<=@AA794,77?@<AA4/*98:89@BDCF?;<>?;GEN=@>A?HHABAHFCIDGAD:;;A>AF56C@7=8;<@9>>$>=CIIFEJ@;>B:=D@CCGCG;39-/&&#.2;=9855:<2<933>EA'1=A:>FE9@A;%&7087FEDEDACD-4()>BA:@::;?>8,5>?E?>2&%$#$&'($+57<9>,-0053:<G8<F@>B<=@9:?@A880804,<;89966)' +@SRR11410539.1607713 1607713/1 +CATTGTACTTCGTTCGGTACGTATTGCTAAGGTTAAACCAAGACGACTACAAACTTAAATCGACAGCACCTACATTCTAACCATAGCTGAGAAATCGGGGCCATTTGTACAAGATTAATTATTAACCACATAAGCCAAGAATTACTAATAAAATGTGCTGCAAAAATAGCTGAAAAGCTCTGGAGTATGATTGCAGCCAATCCAAGTACATGAAACTTACAGTGAAAGAATATATGCCAAAAACCTCTGCAACTAAGCCAAAAGCAGTTAAATCCCATTTAAAGTGAAATGGTAATTTGTATAGTTTCTAAAGAAAGGATAGGTGTCTAAAGAATCTAAACCACTAAGACAAACACTTTACAAGGTAGAACCAGTACAGTATTAGGTTGCAATAGTGACAGCCTTCTCTGTAACCACGAAGGCTACAGTAAGAGAAGGCATGCCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTACAATACGCGTAAC ++ +#$((,30125;=E@>,+.-3+735476=<=3A>;770*7)*87=21*3<934+%&%%(589:85/..6::@A?8976*9<=>))*,;;A@*9>?:<*2A9868;=H@>:G>?=>;==?=?48<2232(-$$**&12&'+1..66@?CG?BC:<01.#$(&''((/.,'*-0(')%%&'((((,#,07:A66:++,$$$-.&&:7873-,0,+)))$%%$%&+34202(>C<@38,,4476,(')+-:?54%-9@=?=99@@<036;<EC>AC:<BC?FF>AA-'*/61??;=C<>>DI<:C@@<B>1;0FG,07(%@?B83=9A>:A8IS;+C?36:=?@@BFA>CEC?<89><@$$&542--+$').+A>?A;@9,'.)**039@:==?<<9745/-*#$%'+0,0263/--+)##'&&$%'*,.'2667,,+5+7;>793/-.00-0(<AA8:>AA5+0;CDLD?<:58899:9=9112%-%*$%$$1.101..&'$ +@SRR11410539.1812663 1812663/1 +GATGTCACTTCGTTCAGTTACGTGTTGCTAAGGTTAAACAGACGACCTAAACGGAATCGACAGCACCCTACACTATGCGGGCAGAAGGGTAGTAGAGCTAGACCAATAGCAAAGAATGACTCTTACCAGTACCAGGTGGTCCCTGGGTGTAGAATACTTTTGCATGTACCAACCTTTGATAATTTGCAACATTGCTAGAAAGACTATACAAGGATATTGAGTGTTGGGTATAGAAGCCAGTAATTCTAACATAGTGCTCTTGTGGCACTAGTGTAGGTACCTTAATGGCATTACTGTATGTGATGTCGGCACAAAATAATCACCAACATTTAATTTGTAAGTTATTGTACCTCAGTAAAACAACAGCATCACCATAGTCACCTTTTTCAAAGGGTGTACTCTCTATTTAATACTTTACTGTTTTTAGTTACGATAACCAGTAAGACATAATTTCGGTTAAAGTGGTAGTCTAGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTATTCTTTATAAC ++ +)%/&&$#$$&&%%'%#%62()#&$),58:24,:67;?AA>A<5)))$)#'02&)%(:<;C<A98:;=-+(12595++0%(0,)(-,---5167))&0826:178BE;=6745+%(..,.5:80.669:310/,&,8:*+++3/,&(+0&'&6';777<BEC.2+##$*A@00>C>B?:9C==EHI@C56>98<7624+,,)$%#$$$$&#&,8=40D/2&96696+,000+(%%,'97A9:=A::;77;D*;3<D=E>@AA;48::,,-'+4,+$''%$%'',88400.--046525;00<>@B=55$),,-..);<<B=?;88-.ACPNE352>D;<694;.$9<725775.%,.147?A889?87//6-)&68,,;9>:>??CI87.0&',-A/54?-4(:45:<8#%%%66;E??A<:<KGB9@B<507506<B@=@?67(=645//$12623;<*+')8,/)&,085<5@;B7);320%48:@A@:=>@AB3434870)1&&,1)((,$%$$# +@SRR11410539.2462459 2462459/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAGATCGACAGCACCTTCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCAAAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATATCCAGTTGCTGTAGTTGTCTCTCCAAGGAGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATAGAACGACTCTGAGCCAGTGCTCAAGGAGTCAAAACGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTTTGCA ++ +$**%)(//0(:>*4+87:90.11),4><AC'=<9>A@6))38:956/58:/:*+/%6:;99744566:5:*1*,5=B44IAFGECFB<>=A:9;>/@@A/<98739BE@A;ADE<22A@CA555=:5756<FBCC.-ADDHA@BB?=BF<347;6-@?:>=AD479?AADE>>:=3:99FF5=AC2<EG1;CC*)&(;@C)BB??=2340B=A@225=BC:98'((7:@DGBDD?88>;;5099274..33/.*-%$**+14;?D?FD?>?<>5;<C>D@ACGB98=C?.)&&-*02>?H@D><11837B:B@@A;:4400/?.-4AEA?7;4456?,3<87:0103@?C5=>D??@9.**-+1;ADKKDFC931;<@A9:-$8.A34B=(>B>>GG7HD>@BC?@GG99@BFEIDAJJFJGC?7/%%).4?CE?>=>=BC;4CC=A1>DG+%$707(*%%)$(&3=<8?54S?AE>JEJ?BC@<@A?A<=EGG??BCCCCB>66:>@9:83*...*.' +@SRR11410539.155783 155783/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGTGTACTCTATAAGTTTTGATGGTGTGCTGGATATTACCAACTGCACTAAAAACTCTAGGTAAATGCAAAAAGTCACCATTAGTTGTGCGTAATATCGTGCCAGGCAAACCAGGCACGACAAAACCCACTTTCTCTTGTTATGACTGCAGCAATCAATGGGCAAGCTTTTGTCATTAGTATAACTACCACCACGCTGGCTAAACCATGTGTCAAAATCAGCATGTTTGTTAGCAAACAAGTATCTGTAGATGCTATGTCACGAGTGACACCACCATCAATAGCCTTGTATCCTATGATTTCACTTGAAAAGTCAGTATGTTTAGACATGACATGAACAGGTGTTATTAAATAGAAAATAGCAGCAACAAGGAACACAAGTAGGTGCTGTCGATTCCGTTTGTAGCCAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +%%24&85;>B=7G<61:@>/;683363>;77/;36031<??A?BEBA31<=2=:<8711<A@>@ACDDC??C@=CAF?BAF.<?ADRH??;=;93.'#$&(1*':8<B>:.(EDE=45GJOOB>-E-88@?7,=89:FE5448>AA:9/.0.1,3*:688C@EB@995B77836?CGG>HDABHDD9>479:53*2,,()*237:@D=>?A@87@EI<3CFHB9CAB446>=38+ACDGF>78,,1./<@@4,*<965.BDE@:<I@EDEIM?DCB>?4;7>CC964/1&3989BA??72+-+(-+84463<:<@92++4-9=B?6=<:28((8>AEB@;73:<8/<,,+<7;;@B<;?66:;4<>>?@KAC33277<B?82?24GFBDA@EFA498>?B@8>B?@==BC<DHD:9@EGHA55=8IF1A&+>7>$$4)*&@BB@FC45<BI=CBEEA@:==@B@>=6B85)%%%%&469949:::@AA?@@@?6A)*23.>>=7/*$ +@SRR11410539.59239 59239/1 +ATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTCGCACAAATGTCCTACCAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAGCTTTTTGGAAATGAAGAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGAGGAGGATTAAGCAGTATAACTGAAAGTGAAGCCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGGAAGCAGTTCTACTCCACAGAAAACTGTTACACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACGTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTAGGTGCTGTCGATTCCGTTTGCTAGATCTCTGTTTAACCTAGCAATACGTAAC ++ +%%&17:0046;C/,&2%)%&$%%%+(3<66+;A><>)6355?=::=>@;=5:,0+1<<=B<9=@B>BA;B11>=:<B;<$$,$$%)1)62<>@IF=?>688%'14576'349?:CB-%68<?@)2<+BIJOK@9;-/<5,,/)*#$*0.++++'&'(2(-013613/'&4/57><?7;@DC34:CA+%07'4++&1%5556%+'&%,+%%*-,-&'&+$()%001=<8<FD@AC?>8'9=B><879=AE>?>11=GJJ>47++'&**+2@@>82/60&&&#$.047@::@C>87,041+''$$#'&)+%''10865:3:2*)'''%'&(.18:8/))(*.,/,-0=@@=@@EF=BA?A<**9=4;?;?:79::;D>GG?61(0:;6++.1+'01?1167C>>><<%977*'562/;.?6<B8?+3$8(-5:<7=CDC2D5C<4=,'-=@ABBF?99817<=;8798>87B@<:@:C@@?<:<<D?8($'%&&**++-/;=9<;833'*,?@AD989'(# +@SRR11410539.1312921 1312921/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACTAGGTCTTCCTTGCCATGTTGAGTGAGCGGTGAACCAGACACTTATTATTATTGGGTAAACCTTGGGGCCGACGTTGTTTTGATCGCGCCCCACTGCGTTCTCCATTCTGGTTACTGCCAGTTGAATCTGAGGTCCACCAAACGTAATGCGGGGTGCATTTCGCTGATTTTGGGGTCCATTATCAGACATTTAGTTTGTTCGTTTAGATGAAATCTAAAACAACACGAACGTCATGATACTCTAAAAAGTCTTCATAGAACGAACAGCACTACAAGACTTTACCCAATTTAGGTTCCTGGCAATTAGTGGCAAAAAGGTAAACAGGAAACTGCTCAATGCTGATATCTGATAATACTGAATGGGTGATTTAGAACCAGCCTCGAGTGCTGTCGATTACGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +$12-)(%&*%2;5)$;59:>;CA@F@B==>2FHA?B:A=<AABC>AAB<<43)+*&2453,*2464-8:B;<FF<>CG;C?:=@4/0)95320.*1;87;)-$'#$%$%%%$().1()2**8:?A:';''*2945:<:>>HG=FAE@@@<AC/CB?><37::>=A/'126:@>C@<>?C:::58::?>6:574733*8789;&&8==6.1359;=;())1AAGGJIMG9:BECGHLC679E89@;<?,'>12=@?:8-2;:;HADBEDJGD;<BDE@6?57.=>BEA88<E<;881)13-,$%)%%9:1895//389:5?068;?F=348-9%)&34,;>>95%%+4&&$$%(#(:5>E=>:>I;<BA=B>&*4)'&@@-*&&?757&0)24--(#)$$%%#$%##%)*63/;*88'%%,,59==DC7:;:12;<9=9;<@9/<@=..&%3><:F?7::32%#-6FCJEEBD;;=<AAEGHA=>;879423=>=F>82)*## +@SRR11410539.1510751 1510751/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTCCTTTATCAGAACCAGCACCAAAATGTATAACTCTCATATTATAGGGTACAGCCTAATGTTAATGTGTTTAAATATTGACACAGTTGAGTATATTTTGCGACATTCATCATTATGCCTTTTTGGGTAATGTTGCACTATCACCATAATTTGAAGGTCACACTTTTCTAATAGCATTCTTTGCATTTTGTAAAGATTAGGCATAGCAACACCCGGTTGCCACGCTTGACTAGATTGTAATTTTGGGTAAAATGTTTCTACATGGCCATCTTTACACACCAAAGCATAAATGAAATTTCTGTATAGTCAATAGTCACTTTGACAACCCTTAGAAACTACAGATAATCTTGGGATTTTATTATTTCAACAAAATCATCAAGTAATAAATCAATAACAGAACACACACTTAGATGAACCTCTTTACGTTGCTGTCGATTCCGTTTGTAGATCGTCTGTTTAACCTTAGCAATACGTA ++ +(%%&,.-+,10321-(4@CC;=?I=B@D?-.2HMHDI>9,,/,/.+*3335:8+//210/42/13377A6>6::DE3.6@01@B4F+:?BBHHAC00179:<?A39?=DFF>@-9+:HA>B?CB%>74)>CDABDG@HBDHAEA==@DCD63;<<JCB9A=BEDF=:7('45:ABB?3.=9:=<=B=?::)%-%)0+13++2<.B:<0<6843586.1,3*-)(36-5>?C<<=>-7+9??CEAF?@?LGMBDCA@KIED>?*('<=,,;4(8<7;@959<@;78=GC?B>>6555.(#'%+$%->BEEB@A?/5=7131:23?C;=8424A;>B=@?BGFD>'>6:7@GIJ=:D>EG@=B@LLEBAB@?:/:790>AC=5:4=?569C:;6()54.-/++18156B==BD=AA<>86'(&&<CFD@EA89>>>-.;>?=A:?;9F9<;?:;5<>8-0%%$''*<)<942(,0&'++79:02++(+'&''&$%('+44B@9BCGCEAD8<8=++$%-&.3;?AE<<<>C@?=>C:AAB?>>8-' +@SRR11410539.2040419 2040419/1 +CGTTGTACTTCGTTCAGTTGCAGCTACTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAATAACGGTCAAAGAGTTTTAACCTCTCTTATATTTTAACAAATCCCACTTAATGTAAGGCTTTGTTAAGTCAGTGTCAACATGTGACTCTGCAGTTAAAGCCCTGGTCAAGGTTAATATAGGCATTAACAATGAATAATAAGAATCTACAACAAGGAACTCCACTACCTGGCGTGGTTTGTATGAAATCACCGAAATCATACCAGTTACCATTGAGATCTTGATTATCTAATGTCAGTACACCAACAATACCAGCATTTCGCATGGCATCACAGAATTGTACTGTTTTTAACAAAGCTTGGCGTACACGTTCACCTAAGTTGGCGGCCATACGCGTAATATATCTGGGTTTTCTACAAAAATCATACCAGTCCCTAGGTGCTGTCGATTTCGTTTGTAGTCGTCATTTTAACCTTAGCAATACGTAAC ++ +'%%&&)++++09B6.&(%&%&%#&*$&'%&(:6::@96,,6+0.-%'++-*0150:9;78,'740>:E?B<BCGEF=BDB'('.;BG=7:=<@77-%%&7.<>HC>@?BED55G@.*,.?C6699:4D=CCFA>C@A93=*-A3/@;:=E?@BD;4:<FA5.06;686-989B;C=?==/BAAAB8<8;=>BA?B==FAC?EA?>?@;)*,89:?C==<<:&'$%'20.'0;>9957::;;;A=?DFA3/,(;5BE<@>CA<;@H7;=8:DB=DHC?@=<=@E:@A:=DGJGHG?;B<77<2).&2;7.&%*543A3**=:9>FEFCECAD@ABG>205*+-*-01:5?=?A@7865/.5=540-%%%26,&5,+%?@LF=;(->22:<<;<8%%%%1<??:@??EHGA;95>237AMMO=A<@:GE692+D+3-970678>F=6>:>%:<=9@@:;=C5ALFECCCB;>9<(%&*>?CEC@@19&167A=CBA31& +@SRR11410539.279380 279380/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACGGAGCGACTACAAACGGAATCGACAGCACCTAGTGAAATTGGGCCTCATAGCACATTGGTAAACACCAGATGGTGAACCATTGTAACAAGCTAACACTGAAAAGTCTGTCCTGGTTGAATGCGAACAAACTTATACTTAGGTGTCTTAGGATTGGCTGTATCAACCTTAAGCTTAAGTACACAATTTTGCATAGAATGTCCAATAACCCTAGAGTTGAACATTACCAGCCTGTACCAAGAAATTATAGTTAGACACGAATGAGTAAATCTTCATAATTAGGGTTAAACATGTCTTCAGAGGTGCAGTCACATGTCTTGGACAGTAAACTACGTCATCAAGCCAAAGACCGTTAAGTGTAGTTGTACCACAAGTTACTTGTACCATACAACCCTCAACTTTACCAGATGGGAAAGGTGCTGTCAATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACAATAGCTT ++ 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+CATTGTACTTCGTTCAGTTACATTATTGCTAAGGTTAAACAGACGACTACAAACGAAGTCGACAGCACCTAGGTCTTCCTTGCCATGTTGAGTGAGAGCGGTAGACAAGACGCAGTATTATTGGGTAAACCTTGGGGCCGACGTTGTTTTTGATCGCGCCCACTGCGTTCTCCATTCTGGTTACTGCCGGACGAATCTGAGGGTCCACCAAACGTAATGCGGGGTGCATTTCGCTGATTTGGGGTCCATTATCAGACATTTTAGTTTGTTCGTTTAGATGAAATCTAAAACAACACGAACGTCATGATATATCTAAAAAGATTCATAGAACGAACAACGCACTACAAGACTACCCCAATTTAGGTTCCTGGCATTAATTGTAAACGAAACTGTATAATTACCGATATCGATGTGCTGAATGGGTGATTTAGAACCAGCCTCAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAGCATACAACAATACGTAAC ++ +'(%*43344739?40/5<?4A&&-003765223DPIHJ?:+::>AC@B<79:++))('43/-++7:?CF>--E?DFD=?<HBDE??A6:333@B>>?46'-*''8:77*;A<=17D>>B7<A?=CFFI=6<570-D>>>AEGEJJ?C:=8111:>62@FE@$#$'09>=?A2?77;E@6:B9.9@=::'.&&.//0;0?C<-:8:?EGDHG:?;:5:99B04<6DDIFEFKGIG@A<EB;79<?79=;;=3,+&*&=ABCJ?;=BC1/@>BDFG<=7CAA@8016589@H@34A<C=<BA/,<,774*(%%&//;<7*%&**..''&)(4>;:>=//1269:<7;<=;@@C>:775,2,0A5;CDB:9311*'&,$%$%&,05/0)%+37<<8=CCE8FFGD?BB=;==<4/'$#6?BGF8=D;GBPL=E;@7C@C<??B@33$/-@@BAC=@>4FD>@=BCJ:6418;8<A;AB>$-$'*('&''0;<BGECB61% 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+CAGTAATACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGATTACCAGAAGCAGCGTGCATAGCAGGGTCGAAAGCAGCATACACAAGTAATTCCCTTAAAACTAGTCTAGAGCTATGTAAGTTTACATCTGATTATGTACAACACCTAGCTCTCTGAAGTGGTATCCAGTTGAAGCTACAAATGGAACACCATCAACAAATATTTTTCTCACTAGTGGTCCAAAACTTGTAAGTGGGAACACTGTGAAATAAAACATTAAAAGTTTGCACAATGCAGAATGCATCTGTCATCCAAACAGTTAACACACAATTTGGGTGGTATGTCTGATCCCAATATTTAAAATAACGGTCAAAGAGTTTTAACCTCTCTTCCGTGAGAAGTCATATTTTAACAAATCCCACTTAATGTAAGGCTTTTGTTAAGTCGAGTGTCAACAAGGTGCTGTCGATTCCGTTTGTAGTCGTCCTGTTTAACCTTAGCAGCCACGTAACT ++ 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+GGTGGCCTTCGTTCAGTTACGTATTGCTAAGGTTAATAATTATTCTAAACGGAATCAGCCTTTCTCACAAGAGTCAGTCTAAAGTAGCCCGGTTGAAGTAAATAAAAGTAAGTCATTAAATTACAAAAATAGCCTAAGAAACGGCAAACTAGCATTATACACTGTATTACCAGTTATAAGAAATAGGGCAATACTCATTTATAATAATACCTCTGGCCAAAAAACATGACAGTTGTACTTCACACAAATGGTTAAGGAAATGTCAGAGATATAAGAACCCACATGGAAATATGGCTTGAGTCTAAACATTACCATAATAAACTTTGCAAACGAGTGTCAAGACGATGCGCCAGGTAATCCACACTCTCCTAGCACCATCATCATACACGGTTCTTGCTGTCATAAGGATTAGTAACACTACAGCTGATGCATACATAACACAGTGGTGCTGTCGATTCCGTTTGTTTATCGTCTGTTTAACTTATAGCAATACGT ++ +%%1&&(''&''.0>9?GC?82,*)*-64/0-2(,())$%$'&%&),3511/2,30*&&#%#$&%$+))('*%1/3-*%4-@A-/30/&22././.)%$5452+/3,&$(#$$$$&$%$($%)('26==:-9++$2136//-2$*10349;;@@?@=999:*(%%&%*+2/63986,1#&%/05+*-4/6/0-+''($$%$%''*(),+,*-.960067IH?;</-)<;5*&232$%*$$&'$%$$%((1#&+)%&)+--*&%%%%'$&($&''($$%&((*,0-')*42.&+%'%%%&#(+,3:<3><;??ABDDDGDEG=00+%%#)-,3/.563/1%%))&&$)#&$#$#(%*))9:?-;((/'-%,''&.&6764?>=6*&&%++$*81)6723-%&.&/337?>7--'2112.--)2:;=>@?B@>A<@C57;<;92/8=15E@=AD:@DDH@7979=4%'''*-161;;A<>GD7##%%)%..1.&%(,' 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+(%)((($$$2628B=%)%<;0%+)4-45=@8675GKHHK>@>>@;<40$'-/:><@DC>??E62BEI@@AK>8B;9?HJKJ<=A@EEGDCIE@F44BJK<(66@?=DEGECAD=>DC@BC;;A>?(C@@@@,0'('$$(&('6=?;@73:=C@A5?CCC9=9?;?<<F<<<A37:@4&%$&/$*+,&()-4:>AG@A@FDECCCHCD776/?:<@>@BAACDFCG@BF??A8<&';6E?AC/?778@983KJHDHB:*.**,...0,(',-.0;77@<G@DBGGB?=>+59<895A14;@C;76:=9A9??EGCBE*>;@7*/65:?@89/1-),6<AAFAE?DIACFGBB4.066&$&(*+@@@@AF;@:<5@=7HIG<9*72;-ACE>+0@=>@=?E>511,*(*-246;96B?G@B=DD>=9<90,-27+,**/05-2-((')*-.1E?DG?@.;<$&&&B;;?808?>ABFA@7/@=>=:<=@CBC?%(7=>@=?BC<=42A7FDFC95'()1-,#%%'*&&* +@SRR11410539.1586846 1586846/1 +GATAATGCTTCGTTCAATTGCGTATTGCTAGGTTAAACAGAGGACCACAAACGGAATCGACAGCACCCTATTCTACACTCAGGGACCACCTGGTACTGGTAAGAGTCATTTGCTATTGGCCTGGCTCTCTGCTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCGCTTTTGATAAAATATTTGCCTATAGATAAATGTAGTAGAGATTTATACCTGCACGTGCTCGTGTAGAGTGTTTGATAAATTCAAGTGAATTTCAACATTAGAACTGGTATCATCTTTTGTACTGTAAATGCATTGCTTACTGAGACACGACAGCGATATAGTTGTCTTTGATGAAATTTCAATGGCCTAAATTATGATTTGAGTGTTGTCCAATGCCAGATTACGTTGCTAGCACTATGTGTACATTGGCGACCCT ++ +*(.(*&'//164:-<$'$/$-.4223)%240AEBBF?475,<8=4,?AIKAAAEBB76<=;6AB=HKB=?750'%.$$-.)27>B>;52,*')(&'2-06%%'**3B:>DG52<345?@?<A.4>A67?7(795BA@>>DDDCIE4.;==<DA>?=?:<:EIIAA5B5;3-(*/,7B=?AGGFA@E@??%%;@<)-+'%$###$$$138=??;66DAB644750)2:5589?075;,2*$.##'1222::<-(08<F@@85:CA<69+-999<5)*.6;9?8<7912''.>B0:56@>:44.41$#$&/12.$%)'7AB;>=<:0:=?C34:9=?+++-.-3/170*)184+%*(')%$'&%,4>;<?=5..=:@6EML2A@@@320.'&'$*3741-57/))%97@7(&&279457418441$$%%)#&%4,9:<>;2--&88;::;--/**---& +@SRR11410539.1320448 1320448/1 +CGATGTGCTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAAGGTGTCTGCAATTCATAGCTCTTTTCAGAACGTTCCGTGTACCAAGCAATTTCATGCTCATGTTCACGGCAGCAGTATACACCCCTCTTAGTGTCAATAAGTCCAGTTGTTCGGACAAAGTGCATGAAGCTTTACCAGCGCACGTGCTAGAAGGTCTTTAATGCACTCAAGAGGGTAGCCATCAGGGCCACAGAAGTTGTTATCGACATAGCGAGTGTATGCCCCTCCGTTAAGCTCACGCATGAGTTCACGGGTAACACCACTGCTATGTTTAGTGTTCCAGTTTTCTTGAAAATCTTCATAAGGATCAGTGCCAAGCTCGTCGCCTAAGTCAAATGACTTTAGATCAGCGCCGTAACTATGTACCAGCTCCTTTATTACCGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAA ++ +*%&&$,%58::>C?C;>FD<<;<=<;>@=H?%3CDDBGG;B9CDDF@>=776&+247?;=?A30A=>A>@?@6=AB>@CCD9::;;))8*5:AHBJ/88108@:KG;=?GG@<EF;=6BFCAFJ>2=;;3A>ACBC>9;:<85:>,0FC@@A>=:<8;HF:17@+';334*('%%A;?CC?H;>?DE?BBC?HFF;@@34DFKIAAB0B)&'1?=5228:D5F?.E=?IA=46:<BGD5>=>3:F4=AI>>@=8=;<CA@?290/..2-2;A@<81/()0493/1,6??90(*34;8516375-+*68=/))88873?BB/57-.5,8:;:74)$56<EE<?@=234AB?=)6:8@BICB?@DDDC;558;E7?74A@:4=:.6818233CB?=?DGEB@>A52?EGKC==>EF83635-%3BAA@@AE;3;62),2==EGFD8A?CKFB:.@58+(66&$$&<?>=HJ@A;EFI=?LA;B?>ADBIIGCD@EE?:3<1/+*=;5&/ +@SRR11410539.2397387 2397387/1 +CTATCAGTAGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACTGGATCGACAGCACCTACGAGAAAGCAAGAAAAAGTACGCTATTAACTATTAACGTACCTGTCTCTTCCGAAACGAATAGTACATAAGTTCGTACTCATCAGCTTATTGCCTTACAAAGGCACGCTAGTAGTCATCGGTTCATCATAAATTGGTTCCATTACTGGATTAACAACTCCGGATGAACCGTCGATTGTGTGAGATTTGGACATGTTCTTCAGGCTCATCAACAATTTTATTGTAGATGAAGAAGGTAACATGTTCAACACCAGTGTCTGTACTCAATTGAGTTGAGTACAGCTGGTAATAGTCTGAAGTGAAGTAACTGTGTAATACAACACAGTCTTTACTCCAGATTCCCATTTTTCAGTATAACCACCAATCTGGTAGTCATGTTCAGAAATAGGACTTGTTTTATCTGGTTTTATCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +)'%%'%%$$''%&&&(38;988675201/-.(27$(6620@B7;017=@>?7?=:8,(''(1051,)*'$%+.1)(%)$),'44<<+@4@5)'9@ECFJGEC??7153467@@D@?@AE=?AAFA6<55F6...1,$$,-7.1:;;<?=8:<<=>8:@9<88/%%&#$##(0/56$.>=09*))%$&$'&%%*'06B@DB=C687::;A+18:<AA>FHHEAA>GEAA@=>BD%B@DFJEDE89B<AC<;?<;96;1$6>AD6996>?B<>?B1:4CIGIDCDC34FF?ACFA3;B4,65B@;:C-(2532:<=A9:B:=860&-.)>A;6@99>DBCA89794/;666070++-331'*&&)/449:/-')1844'161008470-+-.1548=C8:37:?;/&+2&17;,/&%)+1?AIH40'*>;AEFFD0>>B?7D=59AC@==B?BG4<758873418<?AA66'$%&'+$#%*+,%$':>?CB=?:@??/-22=>:=B?>:9@66>=@8,:>BC>GGA>63&* +@SRR11410539.1200022 1200022/1 +TGTTATTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGCGGCCTTCTGGCAAAACACGCACAGAATTTTGAGCAGTTTCAAAGAGTGCGGGAGAAAATTGATCGTACAACACGAGCAGCCTCTGAGTACAAATGCATAAAGAGGACTCAGTATTGATTTCTGTTCACCAATATTCCAGGCTGCTTGTAGCTTTTCCTTTTGTAACTTTAAAATTACCACAGGATTCAACAATTTGTTTGAATGCTTTATAATCAAACCTTTCACAGTTTCCACAAAGCACTTGTGGAAGCAGAAAAAAGATGCCAAAATAATGGCGATCTCTTCGGTAAGTTTAAAGTCACCAACAATATTGATGTTGACTTTCTCTTTTGGGTTATTTCAAGAAGGTTGTCATTAGACCTTCGGAACCTTCTCCAACAACACCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +$1-+&%*/66;;:C994@AB>1.''&&+-7'(3DMIDGCB><93<3420/567;8:>=;>>?C?>>:=>9<4>7>A>@A@@7&&+9:D93>>BEC@A@6<AGDCCAI;7;GG6201&&#.=9=493909B;<8>;85:67BBAACG>:;56/7C@5<.($/2,:47978:5156*8%.>32=>27A@?D>=A@;;09;:>=::?<ADEA08>8611-'()$%.,1222>565@@?9;8737;:?@>><A@<@C;::95,8D:;=CB69D6>>=89;114<;5+,10+0,,+)*(/4(&&&-3:;47/4774$%;678<@<?.28632;E<1-$)3F8>=IFAD=@GH;@A?C<ABAG>3#$3054>@?CEE>55.'(&'.:=>@?<91&%%+:<:KKEBE8;97)$&$%,9::0D78/?A0=:<D?A44-8&7:;<-=<?<57=79:=:=55<::::833-)'(0824>@B=<8:;CBJA@B>6@C?D:=DCF88BFF>I4;@ABD<CEC/&, +@SRR11410539.610623 610623/1 +CAAACTTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCATGGCTGCATCACGGTCAAATTCAGATTTAGCCACATTCAAAGACTTCTTCAACTTTTAAGAACAACTTCCAGAATCACCATTAGCAACAGCCTGCTCATAAGCGCTGAGCAGTAGCAAAAACTGCATATGATGGAAGGAACTAAACTCTGGGGCTATAGCTTGTAAGGTTGCCCTGTTGTCCAGCATTTCTTCCTGGCTTGTTTATGTCTACAGCACCTGCATGGAAAGCAAAACAGAAAGTAGTGAAACCATTTTCAAAGGCTTCAGTAGTATCTTTAGCTAAGAGAATGTCATTGTGTAACTGGACACATTGAGCCACAATTTAGATGATGATTCTACTCTGAGTTGTTGCAAAACTGAGAGTAAAAACTACTGATGTGCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTTAACAGCAACTACGCTCAGCTT ++ +9,-'$#*.2456;E(/%*027:=<7<-:::''/?E?GJE;78977558231315'-,2;DAHAG:EBAAA=9B;A==*>@@CB@HF:?DA?CA<67;HBFGEDBDEEC:<IK?3DALC?A>A:;CHD@@<B=LI>6+$8;).BC>>9988://3C6:><)83??D?EEC99:<+,$.+//AB@@/2*)99B1);>@9<B..98>;<B=D86B<@EG8C;E<%%&>>?GA>JEMLC7$%7;<?>BBGE@B@:11;>45;>>A;=;$((&()*.2:9<@@B<D@CA@B@<<80079=9<8;8;AIGB@175A?@?9A2<B9K?<=BCCD9?FE.0ADGH4.;FK@HF=?PJF=D834539A8G:>:@>DG<HFCDF=@BEB?CJ>=?97862'(121:??<CB77E>?BA?72;A@>><BJI?MJ1@EEI=7639&*228931+=>;BBEBD;CAE??@9>884.<A@AH+139DEM>=369<:<=<>99<700+0$*()*+)-%%&&'%((' +@SRR11410539.874918 874918/1 +TATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCCAGCAACTGTTTGGACCCTAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTGCTGCAGGCACAGGTGTTCTTGCAGGTCTAACAAAAAGTTTCTGCCTTTCCAGCAATTTGGCAGAGACATTGCTGACGCTACTGATGCTGTCCGTGATCCTGAACGCGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCGGTGTTATAACACCAGGGAACAAATACTTCAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACCTAGTTCTAATGTTTTCAAACACGTGCGAGGCTGTTTAATAGGGGCTGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +#%&(4:8=D3:3I<4/9??@>@>IEF:>>55?@BAGH8;6:3.51567::;4137-455691:+;<???8>2<633>AAA<3.0=48&&4?9/;@@=?FCGIIN<>EH138>==AAI;@9@=C;<:?<>88697<1179;DA7'&&$#$,>?5/,94?;112/0(*+'4<A;@@<3392011+?=@><;:=9'+8%>352@I?>;9;**(A:=B22,-&%&.64BBFCJDB@:45:7BA>67.%%%+3((*+:9A<>;DEDF?BEB4H>??>@BD=GDG=68<./387>.5)1)*(59<?C:@<CCB7ECAB95533,%5120&3;IIBCCE@AAE@6..512-+$$).8;>EE0@@=;/.27887=7CE))1%%)3;<AD66*<,936/3AED>(,44=?<==16:5<<<9417771*$)$%DG699;;;BCCRAFHKIBF@?I?711BB0<?C?>AF9A5?G@),)/A<;;96<41EF==7ADD;<?74:<=AD@DECDFDC@1(.356>GH@AA;-( +@SRR11410539.1808574 1808574/1 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+)&((3430008?K5:3=8@B97><:8%%-3.EGCBHG8748:8967+++-)&)%02/-6:>@<:8:957?<;;@HHMGHGEEDGAB2)069=C=A88/,18<>=>@<6(5'356:C?CC?@AC9259AE;-6:8<<7??;B9536656))*-2?DJ=':;8.-.,+)()*&5=4544./?88696132<<FFB@CE;;41+B677649><?7796:C=BD@G>>:<><;<DIGKE<?8$&6:0545CDJD@:;@F676:BAABI6>/..(879ED23;6?<;@@BG:>01/,22'(:<@DCC?C0?'9/?)89(/5<B@=9<=;A*7==>AA<>9A?=89<;=@==?<AABAHALG<@/:+6$%,+0/>1:=??85:-&45;9:'/$*%$%&,,1,2&6;>>>BF?B==:;;:C9<@?:,58:5<CB?AB.(;8=FBEEM;;G78KLF9:6CCEBE?B:;@67.$-840<C<<>BD?7>2:&*AD=78.1-2-/'46GBECC=?:8@=DAB?B@4833877ABEEBBA;2), +@SRR11410539.1630004 1630004/1 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+GTTGTACTTCGTTCAATTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTTGTCCAACTTAGGGTCAATTTCTGTACAAACAACACCATCAATTTATAAGTAACTGGTTTTATGGTTGTTGTGTAACTGTTTTCTTTGTAGAAAACATCCGTAATAGGACTGCTACTGTATTCTAGAAGGGACTTTGTAAGTAAAGCACCGTCTATGCAATACAAAGTATTTAGAGAGTTATATGTTTATAGTGACCACACTGGTAATTACCAGTGTACTCACTAACACAAGTAAACACTGCCATGCTTAAGTTCATACTGAGCAGGTGGTGCTGACATCATAACAAAGGTGACTCCTGTTGTACTAGATATTTTGTAGCTTGTTTACCACGCATTACCAAGGTATCTGAACACCTTTCTTAAATTGTTCATAAGAAAGTGTGCCCATGTATAACAGCTTAGGTGCTGTCGATTCCGTTTGTGAACTCGTCTGTTTAACCTTAGCAATACGTAACT ++ 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+)%$%(-*4409;E8402;>B>;GGFJ8DB$%309A@A(4161<0//69:;<<=BFHB>?9::+0/>><3<,1(7%+,-4803((/:<8:CF;21383283.67*@?CBB:;8/%0')7:8988E?>:AB@@0/0/;3)66.+-/3334')'*)).<9-';'2(;;<::>>27887?9FAEE?>>>::B?@@935>:7>:;))>=<?A@=;1335FFC=@C>@B@=9<:2*-%&-**+''),6>?>:38<8>3BE8BCB@5&&,-.2=28+-*&$'(01,<9??9<;79))345,(),233/:<<76=>A:+5'*%$&(,B=>;>485=@>>GE?B@CA:<9.,0/)*('-(2,3+)%%'3/24201-++//-,=7<=A:3/5$$$(#&,$$79::7+0('1==;?885()-'(6--90?C?>82837/.&100?EDD>FGM<2150-)#$&%,0-@<==@<?<JJL?EDA:<:>@:=><A>>;BACG=A@A=@+3700', +@SRR11410539.364789 364789/1 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+CAGTGGCGCTTCGTTCAGTTACGTATTTACTAAGTTAAACAGACGACTAAACGGAATCCGGCAGCACCTAGCACATCACTGCACGCTTTGCGATACATTTCTTTGTTAACAAAAGGTGCACAGCGCAGCTTCTTCAAAGTACTAAAGGAAACACCTTTAAAGAGACTACACGTCTCTTTAAGAGTAATTACTAAAGAACCAATAGAAATGCTTTGTGGAAATACAAATGATATAAGCAATTATTATCAGAAAGGTACTAAAGGTGTGAACATAACCATCCACTGAATATGTGTAAAAACATCATTAGTAAGATAAATGTCAAGTACAAGTAAATAACAGAATAAACACCAGGTAAGAATAGAGTAAACTTGGTGTTAAACAGAGTACAGTGAATGACACATAAGGAATAGTAAAGTATTAAGGCAACTACATGACTGTATTCTGCTGTGCTGTCGATTCCGTTTGTAGTCTGTTTAACCTTAGCAATACGTAAC ++ +,%/.%&()'''+9G=//+168)%%%$&)%1/$$+&/ADC999<@2/**-.,+1524''>01&..1/4*4/:;:@4,,(*.%%$'&356/%%&%49??BDCBB<0*-1//<DD0.%99/+*+/786-9$$$*141%23/*=@:>9:+-/*,*,+())+,,-&''4><=3237:>AE5FE?%&,&4CCCCFB=BHO;<CKACGG;20(;@44789@%824+/CB9BHHI@89><=;<77.4+.)C@-%04881$/+72*/>@,+/<-3*,4;9521'-7<?C>;:77=872*%$&:<3066:8:..2-6533&73$'<<;;?)++97@454EEICB62)9+8E==AG@A5845?A1110-&$%%)501,##'''77===@;.+)))%%&&&;44=><<;,(47@D4B<JEKE@>>45:77:32+031243<<//7-63-67<07*'&)'&$#%&3>@AHG988::-%%*+9>;;GB:44%+%&4%%$$))984&-$ 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+.$''#'%%78:=>I2/)>497A=BB>A22;%&8@B@?@'/,.*-<><;E=;8%3&('$014+19-26AA?<76<:CJAC779<<9<DFCB<@?>=;73.3//8=EFFE=:87&*+<9>8;80-$&&&'//81?A;=ABD<?>?@@@@>=?GC@95>@<;9;;BA?7:4=EC334*$&(&$+%&&&)*-;?A;<C<<B?C;B7217%*%%6<6A6-31%%'(.//4345,#&$&&$%$(>98;,8%-@CB<?GAFDB1,,.6@BGIGDFD=CD<-8,,?==;98,,/5;@CB52:001:;>><<>C8933./16/-'-&,7779;(82030&.8@8ACA????:1(4;8=5>A:9:E640*(=57;;@<<423<<<FG?>GHDE;=::=88<57<;?4482/).$)*.64;*6++5:?D>C@>587::*1(3BFE=70.=8%?FCB79/7:>?<BDD5/0)(-0&2075?23;79=9;?A?976))*/**.$,&&#%(%%%$ +@SRR11410539.750513 750513/1 +GTTGTACTTCGTTCGGTTGCGTATTGCTAAGGTTGTTTAGACGACTACAAACGGAATCGACAGCACCTTGGACGAAGTAAACTACGTCATCAAAGCCAAAGACCGTTAAGTGTAGTTGTTTACCACAAGTTACTTGTACCATACAACCCTCAACTTTACCAGATGGGAATGCCATTTTTCTAAAACCACTCTGCAAAACAGCTGAGGTGATAGAGGTTTGTGGTGGTTGGTAAAGAACATCAGAACCTGAGTTACTGAAGTCATTGAGAGCCTTTGCGAGATGACAACAAGCAGCTTCTCTGTAGCTAGTTGTATCCATTGCTCCACTAAAATGCTTGTACTTATTATAAAGAGCTAAGTATCTATTATATTGCGTAAGAGGTAATAGCACATCACTACGCAACTTTAGATACATTTCTTTATTTAACAAAGGTGCACAGCGCAGCTTTCTTCAAAAAAGTAGGTGCTGTCGATTCCGTTTGTAGTCGATCTGTTGGCAAACCAGCAATACGTAAC ++ +&/1,+)334(4:-?&.7;,-+688?:==2*/,).####)&04BE@DGBDE:=:=ED:98B=C;<G>@DE<>31)),/5037>@H?;=BB==23*+21?><9B:<:ED780??0.?4;%$$$###%&&,'45.56602.BA66?A12@A7BC99:ADJHED=<?:768@;B@BFACDND/:1;=66@CHBC;0,2779'646B==7:<BB=8**25@GGA=6381>1NJ==EEI87?;94248/2-<70,(>?C>;/+7*<<F99<==&?C;:<>D;<25?F@DC@BC>@@4,1'%%*=BABGEGGDCFEEHB9B:<A@@B;5>;=D=<@LF=%$-12041;BEAEDB<@A/364>A560E>9>A9?<>JBFJAGF=8(:69<@870>5=/===AA@B*8177/$$(;=?C?<H??@K>GC7--/0''6AA,)9ACIGCLIDD><D;:<B=B/8LMD>;243;/;9<:9A;@GEF=79;BCH>@A@9;%%8;8;3/#%+')&%&%&)////954**% +@SRR11410539.1357596 1357596/1 +TAGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGATCGACAACACCTAAAGACCATTGAGTACTCTGGACTAAAACTAAAAGTGAAGTCAAAATTGTGAGTAACAACCAGTGGTGTGTACCCTTGATTCTTTTCACTGCACTTTGGAAAGTAACACCTGAGCATTGTCTAACAACATCAAAGGTGTAAATTCATCTTCTAATAAAGCACTACCCAATATGGTACGTCCATTCATACCATTTTGCAGTAATTCTTTTAATGAAGCACATATCTAAAACGGCAATTCCAGTTTGAGCAGAAAGAGGTCCTAGTATGTCAACATGGTCTTGTGTTAGAGGTTCATAATTGTACTTCATAGCCACAAGGTTAAAGTCATTAGAGTTGTGGTAAATCGATTGAGAAACCACCTGTCTCCATTTATAACAGCGGCGTACAACCAAGCTAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +#'$$%,*89:98H?=;;GGA?>AACC;D@AA,AFDBEH3A1?/879A@=@A8-.)*29=:9%%034)6BD;=D=@AA3+(889954@<>C@ABHGI>9EI?44AE<386>II;FADB?A-:?>?F:;99:9956<7423999''(1316=BEPLDF@DG@E>@A>&'*(&%#&%-2321$$*;*6>1+B/66>@AA4.5AC:+BCB@14-;>?@;<B<E=667:;89A@A<6;<=FHAA:',+():78><=1;0++;>?BCH?*+*):?@=>8B?I;CEEBCCAB.ECD85>:>?C?A>BFCC>C==A9DD@87,'&&.9-.7>@:<CB>;BEA=4@??:=>@@79GF?:=0.*($4<?>E8<566;<9:<=>@,809,3.=44;DJIFIC@?G998:/*6*0B<9<GGL70EDCC;?;239>>@=A?B@9:@:=?@@F=:>>.*6;+4?:ACBCC.A456CBKL.2?E<<BC>B?>LE-868AD4:D>9=2,@3CFJD<2-../9;=>955=85*)%% +@SRR11410539.911293 911293/1 +CAGTATGCTTCATTTCAGTTGCGGTATTGCTAAGGTTAAACGGGCGACTACAAACGGAATCGACAGCACCTGGCAGCATCCTGGCAAAGCACAGAAAGATAATACAGTTGAATTGGCAGGCACTTCTGTTGCATTACCAGCTTAGACGTACTGTGGCAGCTAAACTACCAAGTACCATACCTCTATTTAGGTTGTTTAATCCTTTAATAAAGTATACAAATACTTCACTTGGACCTTTAAAAGGGTGAAACTATATACATTTACAGGGGTGGTTCAGTTCTGTATAGATAGTACCAGTTCCATGCTCTCTTAGGGAATCTAGCACATTTCAAATCCTGTAATCGGATAACGATGCCATTACAAGGCCTACCTCCCTTTGTTGTGTTGTAGTAAGCTGTACATTGGCATCATCCAGTGCCAAGCAGTTTGTGTAGGCCACCGGCATACAAGACATCATCGTAGGTGCTATCGATTCAGTTTCTAGTCTGTTTAAACATAACAATGCCGCTAAC ++ +#%'(*&&-..,&*/3(-:14+0%($%+,*)-$$+=<:@C;8*..*87@@<7??5?584;;>:;5224/-'&'(,&9@=))*0.10131)A?800:?).C@8<:92/=340++'&'(*&3:98=@;A<:?5-1''(&,.**&&&(/(+3:=;:.2,2*(/07?A;22606<=2FA??0,-22+/=4@??8;=65&==;>B?BEEH;886.1.+<3)%#+-(&'$&)3*).+%)*#$$)),-'%'/+))(($$&&%$##$%#%'"#$%'')/).*(44:C16))8925-9--*9<24>9C?.,*%$(,.('0359?<>@9;-(+#=?<==;,,2-&%$((0'+'*$$$$%$%('$#%#'#'##'$((++45;77?D=GI=BBCHE89<5*+*+-&&$&$$(*+,(<>;%%.'&,&&0&'&*-(;>D/5-'*'%&&%%'#$2%$))1245%.11/3,&&&'*$$#&%3:??E*-%&##%)$%&+8%%**)/2+.$%$$')*)'(($$+)-, +@SRR11410539.628809 628809/1 +CGATGTGCTTCGTTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCGGTAATACAAGGAGCTGGTGGCCATAGTTACAGCGCCGATCTAAAGTCATTTGGCTTAGGCGACAAATGGCACTGATCCTTATGAAGATTTTCAAAGAAAAACTGGAACACTAAACATAGCAGTGGTGTTACCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAAGACCTTCTAGCACGTGCTGGTAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGGGTGTATACTGCTGCCCGTGAACATGACATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAA ++ +)$$%'0.9<A-BFF@70@?@7A?C<;=@@BID&>GE@C69)))'..0,))696;#'&79;DD:83;=<=DD:;>=3(+%*+'1+7>AABDCDA?>:6530&-&-:<DCBC:C=CE,$67001/$%'('/08<,+&%''**.4744@@$$.$'::94<96BDN:>;;'(7:-*;79<@75-680CDC>:52<-&8?=?=D71)2499?<>;>;9CC:????<<<<:;A9?AA5-:><78C<AFA22CF==79005*))&%#'*8658:;B54444;01(7::D9=?F8948CBBCGAIKC,<G?ABCE<3BAB:AHD989;:/01.47@<<BCE?DEK@&&A?=EH>6>FCHG?GGIHEIKJDB>?<=23>>=@BA)&78780&--/+#$&%%%&%125:3ABEH?5678<@E9ICDIRHD;K8@568C4*-HIHKH*==>=A.@<<F7@C?EBA<BCAB>94=AGG?B9EB@75@48=99?8?BBAGH;;=52+.348<334(- +@SRR11410539.392938 392938/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCTTTGCCTAACAAATATGGACTGAGACTGACCTTACTAAAGGACCTCATGAACCCCGCTCTCCAACATATAATGCCTAGTTAAACAGGGTGATGATTATGTACATTCCTTACCCAGATCCATCAAGAATCCTAGGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGAAATTTTTACTTTATGATTGAACGGTTCGTGTCTTTAGCTATAGTGCTTACCCACTTCCCACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTGTGCCTGGCTACATAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTATGAGGCTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ ++./2>/&&AD@Q17,<0/)A>CBCH<=>::1DHFBE+==<E>CA>;2<:>>;()1B>>A:0,.--.,$%&.''(-/*%%-6:>33478;-*6,8=7::>>BC-+D?7:9=3.-(&$$$$.16.3$5()'(%$&**.+%#(->7=DF?==>66@65:9BF?;2*(#%%%(/-&(-05766A88A=7=++25@**/1''('3;C@=DACB>>D738?8<???BD8>DA?>>A;AAB>882234743/'#$%-*,:9=<:67<'+==3-E;679>:111-810)0*,-.<AC@7//+)))2376810A))*EAF=4=+&+%@?>@<CDAIA?B@@C=11+#�'%%)-%#$%1%..-1(,5:;8105<8DBC7693<EDA+<:56G?8?;<78:??9>B==953..$$&.6/;;<=><;:58790656-AC?=?268FLAGIB?BDB0@DG;JHE>?64CDAB>:BCDKE+=;A@E??B@:+88=87CDA886956438@AAGC9632%% +@SRR11410539.1236414 1236414/1 +CGTACTTCGTTCAGTTACATGTAGGTTAAACAGGCGACTACAAACGGAATCGACAGCACTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAAAATTGTCACCTGAAATTGAGAGTGTTCAGGCATTCTTTAAGCTTGTAAATAAATTTTGGCTTTGTGTTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTAATTTGGAAACATTTGTCACTCAAAGGTTGTACGAGAAAAGTGTGTTAAATCAGAGAAGAAACTAGCTACTCATGCCTCCAAAAGCCCCAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCCACAGAAGTGTTAACAGAAGTTGTCTTGAAAACTGGTACGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTGCAGGTGCTGTCATTCCGTTTGTAGTCGTCTGTTTAACAACAACT ++ +'$&'02568A470@:;55%#%(((?>:9;=3+-&.311-*$-/&,'*%1:9<;8:7894(:0*-4;;EGAD=;>?E@BB>78/(+,,2:26+,,8=@A?@.@33>=B3?523507:8<C<>72@+19=@98@A275:@30+)(('-*/430#$$%&<?@.2/-$'248>BA956%5677;68@=5:<GHIC4978:8*0-/1&&4>;BA>=D;;89B9<?-306;1:?;DGBFICBEE=9:82(+(,;(-'''(//2:1+,*7099<&(2$)(,**$$,5*74=@AEB<845-14<6-095,,,%$$%%++-,7<@=399?&(BGE07ICG;IC3'9?ECEF99JDAKD@@0@>,<=:@5<:**=BC=;99@7<;9@D?@++,,*(*127(-,+,5646/()$%'%'337:?<::;CC>>=?98??4474-520/,::<C5?>>B56*1(#$(.-3890598//,,.-1:<=B74569::>?:;974/.*&&&$%($ +@SRR11410539.1479416 1479416/1 +CGGTATGCTTTATTCGGTTACGTATTGCTAAGGTTAAACAGACGACTTTCGACGGAATCGACAGCACCATAGAAGTTTACTGGCGATGGTTACTTCATTAACTATATGCTCACCTATAACAAAGTTAAACATGACACCCCGTGATAGCGAACTTGTATTGACTATGCCGTGCGCGTCATATTATTAATATACAGGTAGCAAAAGTCACAACATTAGCTTTGATATGGAACGTTAAGCGAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAGAATAACTTACGCCACAGTTGTATGTGCAGCTACTAGACAAGTTGACAATGTTGTAACAACAAAGATAGCACTTAAGAATTGGTAAAATTATTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACAAGGTGCTTTTATCCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCATTACGTAAC ++ +.$*)$###$&('&%2)/:=;732/;?6?7))22>;8<;5272)($&)))'+12.3/9:==@/3+0..+*(-%&&&,/+&4<:>A?@B38&.+'''#'$&.-()(/9''*/9?>?80033835*8)-%+-1%;=78549;+)%#$$%%%+&$#$%&)))+*(),&$$&&'*%$*987?(%%--&-1.,'&'&%&'974@<56+**6834322,7+)'%&,:?B;79;=63'%%($%$%)*)--<@D?6;38;:@A;6:;6688/,()$%()<?A?BBA<;8171?GA?A:10039*':G?77''%*+%%&%%)(56&%'&($('*&79=?-BBE<77776'%%5>??IF?DEIE:;BIK68D6/:9?--056%%%%,&(7451212+55.447;<<?&*9,2%6/2+=BD>A@A==%*9BAA<<?@8?4*/;=>BNF@C9B@99C?ACC88LBA96BC?<<><<;A:9I8F<?.((0.'(/78=CG8;79,8<0$$'4-%'':B?EH>@8D@G999:8:01=5:@?99:5:93/,-+'*01-,&&& +@SRR11410539.143872 143872/1 +GATACATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACACAAACAGAATCGACAGCACCTAGTTTCCACACAGACAGGCATTAATTTGCGTGTTTCTTCTGCATGTGCAAACATTCTCGCAATTCAAAAAACAGTTCAAGGAATTTCTTGCTTCTCATTAGAGATAATAGATGGTAGAATGTAAAAGGCACTTTTACACTTTTGGCACTGTCTTTGCCTCCTCTGAGGTGTAACCATTTAAACCCTGACCCGGGTAAGTGGTTATATAATTGTCTGTTGGCACTTTCTCAAGCTTTCGCTAGCATTTCAGTAGTGCCACCAGCCTTTTTAGTAGGTATAACCACAGTTAAAACACCCTCTTGAACAACATCACCCACTATATGGGCATCTTTCTTTAAGAAAGTGATGTCAATGTCATAACAAGAGTGGCAGAATCTGGATGGTGCTGTCGATTCCTTGTAGTCGTCTGTTTAACTAGCAAGCAATACGTAACT ++ +$)-&%.448:64/99828:?A<5BFFJ=<@??7KHCDGB<>;<77/-23<<:-0'0>>@AD;;;C@=<0),26A:<=32-&(,.,17B<=@@@;>J8.*BA??BB?@@DDF@??@>765%.+.0(('#&&($*0,,)+:69=9A9:00',478>A<@@22<?=>>;>?78,7DC6:588@>@B63?BF;AA>;4*(316;A=?78;A>ACA7()%*2:688<;AA==@<?:;'%%%.678AGA?9799=A>AB?DC?7981376*++4=>88985+,-,03/>6>??139****,$%-%&$(()+400,9%;4AED>24-(0>>>>>DAA>79;;:9*+#%%'*,*,;>995)$8%(9:>@?<JH>89.0:;?A::>658+433()896/,&'$*6=>FFF?NLA618:D??GGGJA:>;<8=;@88:8:=>6-;J@FEHB=?;E>56>:/0C709B=@87@8')+-..46<A<9A<>EHE4.'&&'(&''2/0<=HDE?;,. +@SRR11410539.148880 148880/1 +CATTGTACTTCCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACGGAATCGGCAGCACCTCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGAGGTCTTATCAGAGCACGTCAACATCTTAAGATGGCACTTGTGGCTTAGTAGAGAGTTGAAAAGGCGTTTTGCCTCAACTTGAACAGCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACGCGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTAATGGCAGAACGCGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCCTTAAGGTGCTGTCATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCAACT ++ +&$('586333%(377)%29:3@9<<;=.99./''DHC>@?-)/(2-,*(%%25*8'+&29;%&-0)<8EA@@9>8655==>GFLCB<<?=4/E=;?:490/2:11,,1>,-%&&666>;?64&-+8B<@B@7323,&28,;67@44<A@BG?;;+;>565-4445&:B5696?2=/2%&'*0>=;D+2<<=FCKI<<7:;')++,0071-@C@AF@BDB??9>4>:;76$$8=3681..2.,)*13,===:<A?A;?A?@@;=$%*;:B3@AA04/75*B(@BA8@AA;HAAAE14)),*,(,.<77<8B?A6=4(:-'((,8733?;B@>@HHA?<99;@9A<0./145:-&2<;=@DCB@@%:44(BHA=?+1*##$&&%++1:%%;;?B?AC;H3-7,8>>;>8<<:9&-+4..);+49FFCA9.@2DG=:3@E=>>FHD?@@8=;@=B>:;7...77:()786''<))122/>?6:;63=00427:@<FA@>=6@=>B::9?C:755;@=<>))&&&$$#& +@SRR11410539.492258 492258/1 +GCGCTTCGTTCAGTTACGTATTGCTAAAGTTAAACAGACGATACAAACGGAATCGACAGCACCTCCAGCAACTGTTTGTGGACTAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACGACACAGAGTGTTGCTTGCTGAGTCTAACAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACACCGGGAACAAATACTTCTAACCGGGTTGCTGTTCTTTATCAGGGTTAACTGCACAGGAATCCTATTTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAA ++ +$&$'*.25<04*<280@;<FJG><8::%$.79;7)#'$#('%**+--,,//7>?9?444876382AA=9*+=>CFBD2.35663?@448<A=>F>A>AB9<@B+=EB7>BCD=::8281513E@875=B::805:CHF551&$0//,-'=@C<3&#&&+*,///(:-0035618??>3/227:9/2>==DA?B:(.0&&229??=@565621988@C;>64.-02//99?9779;4311076578>@AALD@>CC6C?>B=3B<<9;<FD9GCNB8;:((961-);>@95+$$*01(414%)20BCGHHBD=;-B(BCGG04FJMABNAGE<=<=<9,.*-)$*-+'/*+&&&.%('**134>=.6@08,((627-&3''$$%))512($&,2/38<FGIKGEE53*&')'?C=;/56=@??>;25-1-40>4435:;98>;501/202CA35;0+/;6=D3.;33=0(+26;@55++5414489@A:()%)%,/..22/.633%+ +@SRR11410539.1935584 1935584/1 +CGTGTGCTTCAATTTCAGTTACGTACCAGGTTAAACAGACGACTACGACGGAATCGACAACTGCCTAAGGTGTCACGATTTCATAGCTCTTTTCAGAGACGTTCCGTGTACCAAGCAATTTCATGCTCATGTTCACGGCAGCAGTATACACCCCTCTAGTGTCAATAAAGGTCAGTTGTTCGGACAAAGTGCGTAGGCTTTACCAGCACGGCCTGGAAGGTCCTTTAATGCGCTCAAGGGTAGCCTCAGGGCTACAAGGAAGTTGTTATCGACATAGCAGGTGCTTATGCCCTCCGTTAAAAGCTCACGCATATGAGTTCGGTACCCACCACTGCTGTTTAGTCGTTCCAGTTTTCTTGAAAATCTTTGGGATCAATTACCAAGCTCGTCGCCTACCAGTCAAATGACTTTAGATCAGCGCCGTAACTATAGCCACCAGCTCCTTTATTACCGAGTGCTGTCGATTCCCGTTTGTAGTCGTCTGTTTAACCTTAGCAGCCCGTAAC ++ 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+CAGTATGCTTCGTTCAGTTACACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAATTACCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTGCTGTAAGATGCTGCTAAAAACACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTATTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACAACTTGTGCTGACAATGACCCTGTGGGTTTTACATAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTAACCTTGTAATGCGTAACT ++ 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+$&%-&,,18;C,:5:DE?A=GHFG?ABC9.A?9:;18--=->??20-/0')0337::@EDJEC@::CAFEAB?=0;618HKCA9>45448@=<=CB;;333CDDEC=;<0/($4:;;2.*+>??@JC@.@&=56,,+6+8D5ED=ADA@BHIFCDGHBGAC?FCD5+%$$$"%.115;:56),5<3666.'021378489=98:*4;=BCC:=;>=??>D>@EB>>=?;9,@A>;//9:==;EGMJE<:756<F>CBFEB?KGCIAGE:;@FG:?=>A?>:=,'77:<>EC?AAC;;+/7511:@BHE=;8?6238,.,9(39;<;@BIC1856)0''9>;8@A6-889DFGFB?:CD*&+;36=A?@@=B9>;5=BADCB:0-+/=7?9.$%*3*-;<>?C//B;A>;CC88>C27+:EG@BC8AGGH:7797+5(CACC=5@DGEGBF6C<A./77@BAGB<A767?:<7<9:04>9;C>>@=C::>?@=AD@;67AACFCDA31) +@SRR11410539.1874045 1874045/1 +CAGTAATGCTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTAAACGGAATCGACAGCACCTTTTGACTCCTTTGAGCACTGGCTCAGAGTCGTCTTCATCAAATTTGCAGCAGGATCCACAAGAACAACAGCCCTTGAGACAACTACAGCAACTGGTCATACAGCAAAGCATAATTGTCACCATTACTATGGCAATCAAGCCAGCTATAAAACCTAGCCAAATGTACCATGGCCATTTTATATACTGCTCATACTTTCCAAGTTCTTGGAGTCAGATGAGAGATTCATTTAAATTCTTGGCAACCTCATTGAGGCGGTCAATTTCTTTTTGAATGTTTACAACTGAAGCATTAATGCCAGAGATGTCACCTAAATCAACATCTGGTGATGTATGATTCTTAAAATATTATCTAACTCCTCCTTGAATGAGTCTAATTCAGGTTGCAAAGGAAGGTGCTGTCGTTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +&%#&$$$#'(.(;G=81>FD;==EFDDBA;GG)-DCCFJ8;254852-)*+)*-0/3645266:B>3BDAFADDAC8;;;:87DHCEIBEBGAD<;;;>@<=HBBC>C:=><<9*0++(+58?)):9:@C5GE>*+31267++-/.6:7679830,CB14?D9=:=0.-,*++;>8;>HB<=;@@>EEEA<<??<>=>;=>;72<89-A<87B?C;>A?5<<712/4;:9002,;<9?7;@<9976665.-,),3=A6=;?9;=A/5,-:7:BF)%&*$'',,9>=A.99BCEA?@?A>>:;@<=;*1578579E1182180/;:0==@9:C<CDGD=:<@579:;C823<:96*0:CECBDADC>@@?AD>=?CFC<;:=G=A23=49?569?D?>A==ADDKFC>?DC@.&&-/54=7>?AH,408;<BDEI<:9A?@@@A@6;59CAF>;=<&74-,%);-.2+'&$'.:=;B>A?BGB=??;A;?CCI442625@.:@@=>:7.'()) +@SRR11410539.2289681 2289681/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTGGCACATGCTACGCAACTTTAGATACATTTCTTTATTTAACAAAAGGTGCACAGCGCAGCTTCTTCAAAAGTACTAAAGAAACACCATTAAAGACTACACGTCTCTTTGAGTAGTACTAAAGAACCAATAGAAATGCTTTGTGGGAAATACAAATGATATAAGCAATTGTTATCCAGAAAGGTACTAAAGGAATGTGAGAACATAACCATCCACTGAATATGTGCTAAAAAGAAACATCATTAGTAAAATAAATGTATCAAGTACAAGTAAATAACAGAATAAACACCAGGTAAGAATGAGTAAACTGGTGTTAAACAGAATACAGTGAATGACATAAGGAATAGTATTAAAGTATTAAAGGCAACTACATGACTGTATTCACCAAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTAACCTTAGCAATACGTAACT ++ +%566;7<A?=?N(<4<CBCA;7A:=9?>568APKGIA;3458;9:>65+.(($)-777=?55277=>;%.04<3((+6?<-/$%89;EC@CDEA677(((4ABHGGCB>BB*&+9D>>66695)::;4483?28GH614;'&,((&($-1/<6;=EE23.9A88@.?;;:;DA@A,(#1)0%(%0656;*A6<;AA::8-2D33599A1>7.%9E>?GAFHI@@?B=902':9<7@<EGD--:7/:?+-.4><=AC4+;$$$%///%+-'33=?A>B:;BE@@DEICF;?E?@9EOH.$'98&<E?@4435-601*.-,,,('$&5>9:<FI8<@<BEIGB?B=G<>G=@AC@;<::@D?44:?B900@=FID?@BE<F>:-/3-))*&-3352BGGICB@?;<>?>@EF4</=//4CE?::6<:<>*/:=+,>AGC8?;:;EAEDA;385=88%-.<6:<40?<9?A;=AEAB051/%64878>8512978;:BDFD>?BED<.%- +@SRR11410539.2225052 2225052/1 +AACATTCGTTCAGTTACGTATAGGGTTAGCGCGACGACTAAACCAATCGGCAACTTTTCTCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTGGAGAACTCCGTGGAGGAGGTCTTATCAGAGCACGTCAACATCTTAAAGATAACTTTTATTGGCTTAGTAGAGGATTGAAAGGTTTTGCCTCTTGAGGCAACCCCTAGTGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGAGCTGGTAGCAGAACTCAGAAGGCATTAGTACAGTCGTAGTGGTGAACACTTGGTGTCCTTGTCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAGGTTCTTCTTCTGGCAGAACGGTAATAAAGGAGCTGGTGGCCATAATTGCGGCGCCGATCTAAGTCATTTGACTTAGGCGACAGGCAACGATCACTTGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTTAGCCTTAACCGTACATGCTT ++ 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+GTTGTAGCGTTCAGTTGCAATATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCATCTTTAAGATATTGACATTACCTCTGTCAGACCCTATCCACGGAGTCTCAAAGCCACGTACAACGTCGAACACATAAACGAGCAAACTGGGTTCGGACATGTGTTTTGCTCTCGTTGAAGCGGACAGGCTCTCATCCTTCTTTCAGGTCACCCGGACAAAACCCTAGATATGCTGATGATCGGCTGCAACACGGACGAAACCGTAAGCAGCCTGCAGAAGATAGACGAGTTACTCGTGTCCTATCATCAACGACAGTAATTAGTTATTAATTATACTGCGTGAGTGCACTAACATGCAGCCAGTGACAACCACAGTTTTAAGAAGATCGTTTAGAGAACAGATCTACAAGAGATCGAAAGTTGGTTGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCGTAAC ++ +$&)$(+*4987)'..3$2#%%(%&$$%$&4;@FF?==>=B=501,7474=03(/'10016989>=E@=93571//7/**;+,+/$$%%+).++#&$%+%+*)'$(&1+.&**:9;:>456((),,&'&4%),+)'%%%*$&%$#&*(%$&3$)(**#$$#&$#(43$&$%%(*###"%)(+687754&1$*)*%&')*)%+(.+(%%&&*.-&*58>3>IG>DACHG>@@B=:%%7,(*%%(&&-))7=6<@B@A?@>EG=A=@56@A<<9:>?7,'>CCFD<//<9992--?9665C@:?A35D867>,$%$%%&''))*)'$*''*01;91/$)-..;*%%$$,:9CA6E>@@:9.$)#1&&+.()(')65/0$%&&%'%($)(&$)%''*&--/7=700/---.**'*7&%*$&%7;2&:,-:7DDD67:=<?B006@>@>4<?BBCC59?FA=28:8<><=ADDCC=6667515%&'($$857()$ 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+&3433/=?A=?D76%**-((*31(36430&&@PJIN=91518=9=>BCGG>9+055+50*(,165;<<?9@?JAB<;1?DECDE=EA:BFBCFB7&2>=?>BC;?GLGM586/.EE?93@2:<HD<A++3,34-$*.&-;@8A=>871##$-.+,23*%$+388@<<CCEB;=7CGEFMA96=><23-0=D:D8</BDBDBBB1/1+->D<;//,+*+$.0378=+0&47/?;==ABCG=8B97:9',.%,+488@@?<=:B>;;=>C@A;?CAA@@F?A>A<<>=99>;;2>1EG:354EC0-.,=<>;=?CC;7288995>BB<@E=AE:<BBD<=22,-&+((++&*86:F=A=?A@CD><>AGD=8425.9?6695,+''&*'((777?85/0(:-.1&7/?EDBEDEBBB2,/<<>=4&%*337679698<:>441$$$$$&%'%,=667.%'(#25--&/2@7D>>972554799853+.*,%$$//:>?@<'.% +@SRR11410539.1980880 1980880/1 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+CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGAATCGACAGCACCTACTGTGTTATGTATGCATCAACTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAGTTTATTATGGTAATGCTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATACTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGGCCTTTGGCCTCTTTTGTTTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAACCATACT ++ 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+%$&'3630:09;A:A=>@@1<==:?B?C=>>%-1DD?B/,4019.-,+//479:5;6=;>><:A=DBGFKA?A@+6A9CCE??EBDD.<$;:>AB6,-&'%$%&./(BE4)+--,36<><:2)4=,'/'((6;?<A?C@>BB?ACHAC34*1,;>7986??<89@>=86:6A;<<?%-?@><0.,)(('.0/85:C:C>7@98;BBE>89C15D;<;8':;3:<23*3C+>)8<:6909=?>A@=CCA<@=66*((-351;0.9;:68=;<<4/*90/14/4)*.01(0''&&3:CAA7B5/;*,$$$%$-'$+*1:9:;22.(.157827AB@CAECGB>>85.00(*(('+'156;E<>B@?=5CEB;;836*,+2359:=23:72++3-./12?>=>@F=?H>FH>AADGEIE>@;<<9)+14==;;>@518?AABCFDGEEA@??<A>=?A@33B;3+>79A/:62248:><<(:45;;>?AABGC<=>OKKD@B=8=>>A9;870 +@SRR11410539.1158374 1158374/1 +CAAGCGTACTTCGTTCAGTTACCTATTGCTAAGGTTAAACAGACGACTACAAACAAAATCGACAGCACCTCATGGCTGCATCACGGTCAAATTCAGATTTAGCCACATTCAAAGACTTCTTCAACTTTTAGAACAACTTCAGAATCACCATTAGCAACAACCTGCTCATAAGCTTCTTGAGCAGTAGCAAAGCTGCATATGATGGAAGGAACTAAACTCTGGGCTATAGCTTGTAAGGTTGCCCACATGTCCAGCATTTCTTCACAAAGCTTGTTTATGTCTACAGCACCCTGCATGGAAAGCAAAACAGAAAGTAGTGAAACCATTTTTCAAAGAGGCTTCAGTAGTATCTTTAGCTAAGAAGAATGTCATTGTGTAACTGGACACATTGAGCCCACAATTTAGATGATGATTCTACTCTGAGTTGTTGCAAAACTGAGAGTAAGACTACTGATGTGCAAGGTGCTGGTAGTCGTGTTTAACTTTAGCAATACGTAACT ++ 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�>,2FF@;?B=;;46:17;9:89;;;2A(.:80/*&($ +@SRR11410539.97901 97901/1 +GATGTACTTCAGTTTCGGTTACACGTATTGCTAAGGGTTGGCAGACGACTACAAACGGAATCGACACACCTTGCCACAGGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAGATTATCTGGCTAGTGGGGGACAACCGATATGGTGTGTTAGATGTTGTGTACACACTGGTACTGAAGTCAAGGCAATAACAGTTACACCGGAAGCCAATGTGGATCAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTGCTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTCTTGTCTCAAGGTATGTGGAAAAGGTTAGGTGCTTTCCCATCGATTCCCGGATCGATGTTTTAACCTTAGCAATACGTAA ++ +)#&''%**,&%+690+%-9:3')6.0/;=;;=:;)/$2-(+))&*)2235..34'-%)%<86,+&%%%--//'&&$$%-,'%)**;-9:79.2/*+/.2116/0+2&&+&-%10.-0;:;:D<C@=B@7FBEC>@JGE>5@9;=IH<;9?<A98E8?A6608:7&%&&0778*5:82;;9,3>57'<3689A98,-(&*+/(,$%,'//5590<6513057=9-/<;::9=<:81,&$,+2')%0453///./8063.<1:6;18'&$&(%$'(*+1-<*239:<AGE01<8:77+07;9B=;</251'%$'*&(**3=9@?70:3;/58;6((@6777898+/'35/8=AA6900>?>KR6&'77))553,)6:9:92,-543+/%&((('%&)+9=ADCBB?;2*869=HGJ>349((+,-983441-;35+&&'&++'$$#+7;:33==>.35(9=<8-,/+*').3$&%+.26224())$&$-.$$-$+,0-&'&'%((*.3399210&' +@SRR11410539.822872 822872/1 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+--/0365:=>:5<*-%(%+#$%)'+,%17''0=5;=?79$$/3864*('--+/#$,(68:9:9:79;?@:?DA.8+,%-5<7>=>8-1:3:685FI7?;@;>G>=>33;==;<<A>=+<=::0?+47E?=>-/,''##%%)+-..::/010''''3443;A?<<7CC8&'*$$+313'534-9;:1,4)%)3769,1218:89>A>FKGDAEB@??ACBE9C;<-24;>B<>AA?@<=9=??:$'<<A7/**354(:11217:@;>83-(.4;9969,,9;?501820)/'*++,,9855%(&&,**,.,+$(,43+%,+)0&,9;;;6)&)69?0'4(7;969&(//7DGG78/3?=58%$?78:28;?>61/.%%'*+*()%%7066AEIC@@BBA>ABGDB;@GA7<449<;:80*%*-734?02*4$)+,>7<@>?@C@@9)*'2&''(CD@<<.5512664-&,9;JC>?<BBJCBAD;?B<>>?85-.$""%(%(%$# +@SRR11410539.1370297 1370297/1 +GGTGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTTGCCTTGGTGATATTGCTAGAGACCTCATTGTGCACAAAGTTTAACGGCCTTACTGTTTCACTTTGCACAGATGAAATGATTACTCCAATACACTTCTGCACTGTTAGCCGGGGTACAATCACTTCTGGTTGGACCTTTAGTTATAGTGCTGCGTCTAAATACCATTTGCTAATACCAAATGGCTTATGATTTAATAGTATTGGAGTTTGCCGGAATGTTCTCTATGAGAACCAAAAATTGATTACCAAGCAAATTTAATAGTGCTATTGGCGAATTCAAGACTCACTTTCTTCCACAGCAAGGTGCGCGGAAAACTTCAAGATATTGGTCAACCAAAATGCTAAGCTTCAAACAGCATTAAACAGCTTAGCTCCAAGGTGCTGTCGATTCC ++ +%%&&(+/.45=89B@<7:FFEECCHEB:<B12-<?DCF6BACBA?>:>:=>@6@:=:B<>98)4':=:<7A?3/1///.:96*&'.%%--,%&&,-0+%*,1907,,-,&/0<?:40.2753/&*',&'%$#$%&(%+*,++:1/+:::99;.%1-'4244)+%&457362,),*&('*%,+0,(3((A@9A@>E7C369..).22347.$+%)#%$%&&%&%)$+&)268868;9>>G9:3&3---33385())))/.$$#%&79*-%+"$'*,$/&*(%#$#'+6()==;727+684.**,-77,-()061/-/,+'&$'(*9@BA56($3531957:*+&%&,26@:<>>9=74367),<=35(*5%4*+(&($$$$.3-,06=?4,351)%%$&159A448<CB<951%$./&((*$$##%%%$'+-,.)(0%))++.45)7//-,>5584.2-+36&& +@SRR11410539.1893571 1893571/1 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1317217/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAACCTTTCCACATACCGCAGACGGTACAGACTGTGTTTTTAAGTGTAAAACCCACAGGGTCATTAGCACAAGTTGTAGGTATTTGTACATACTTACCTTTTAAGTCACAAAATCCTTTAGGATTTGGATGATCTATGTGGCAACGGCAGTACAGACAACACGATGCACCACCAAAGGATTCTTGATCCATATTGGCTTCCGGTGTAACTGTTATTGCCTGACCAGTACCGGTGTGTGTACACAACATCTTAACACAATTAGTGATTGGTTGTCCCCACTAGCTAGATAATCTTTGTAAGCTTTAGCAGCATCTACAGCAAAAGCACAGAAAGATAATACAGTTGAATTGGCAGGCACTTCTGTTGCATTACCAGCTTGTAGACGTACTGTGGCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACATGTAACTTTC ++ +0++-.4/79:7@HG82BJH4>@<>=>:;B==&@CA;<.>>?B=A=+:;966'3(-)347<==6608>?G@@89663,236<@A:46E<>9B-47*@AA94A<9<+)%%$$&'(&+44:@::)12-@=@;>--0=:<@:?@9DE5.=<>31:97242+58;:@C*(77:<;>?:>BC?FGB>**2*+,*+3)8877;9AC@6;,+$&499@67E?;9438+0(0(9/06=?DFD@65;?ED@GG),;49<99?GA=@D1BEBA8;9999?59=>>01:@@D3++/@@@@GCBA05:312$-44&+4=885B@89B>AEKA9:>6A998:21=C?J@03@@933?<<:;@A;@:A;FD>?<?BAD;8334///,%3.7*<BCGCA978=IKC5?=F=E=<037BC78@HB@CIC?<;67,+,,,886=C:?<=DC<@227<:72:ABD>;@8067<8>EE0:@A8947A@@A>:A??DA=<588<++*)586:=<<6:@<=CAD2=''<=9)....19:5694' +@SRR11410539.724924 724924/1 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+(-.-89?65E7<%-55=;9;<014>:AA&4F??ADE?<;A89;5<<;786&).3./316)+96:>;<=?8?BDD;B%+2D-@FEA;596=>0/29+=><@@?EF88548;+,&'*3-099;=782*?ADAB<?>>85467897,3016B;=<99CAH>@=CH@GJH@/98<<B@@A899A=?B=>77A??=A,-@'(850*,*(-,,-0110==))0.///4428=6253>A?CC<;;A=>@=?8::<;EA;=,ABF@=>>:4*/'.%((,++2;;9IJ<;A;8@B84<2-1(,2-3341*%'$$5379<A>EDA<C<:66;+6=>830343>;;A@9:?@=;AAADFB2714299>.)7345))*=B>?ANIAC@B:CCBNN<2*&BD>CC70B>A<<B=7=<2*:>F;<:-1895$..780*,<<B88;<GG@EFH7)'*(5()4226<GBE@?=??A876:AAA>@;>@::::>;DCI<:D@9:63?11?ACBB:,*.699CC>C=::7+$ +@SRR11410539.1888160 1888160/1 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+$#(%&%$.8;<?J;C=?LII862224::@562DMIJMB9))3;AC?>E>>>A=79AA;==BA@BEC=9:00%)GKDBAGEGBCC<3,.,,-9=.7D54@>@C>;>@;@B<?@:?49=?DK5?;>D@D==:?CC<+''->;0022174/'/$026;;</+05?.%&*A@DF@;=<9AA4642,,/00/--)$$(-4;?<8=A>:>;<AB=<98321/1B76)0)8)0B>>@/;940)'9<<7%%19;,,&&*+88;<:2225**+-)/-,,.*&&/9:AA9:/7@FDEADEB@++9)))(*0/25D?86<9;69-.8>>EBE/),-,AF@<<8411>;@:F?@DAA1()*%*%(989<AFCBC@ABA5)%((),,5>>A?=@=<9;3:@;CBB>><8808,'1)%%'&&&+=?B?HBBFAC<@8888<@F6>9<73*=@F99D?AKHLD>8921=CF?A?A77;=?A?>:3%&>@BCB+->B:@?B?A45;%%.*9<B?HACC>8<76:7611/#%%&*5<;>:20/%(- +@SRR11410539.646790 646790/1 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+CATTGTACTTCGTTCGGTTACATGTACTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTGGGCGACGACTTAGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAATTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCCAGCCTTCTAGCACGTGCTGGTAAGCTTCATGCACTTTGTCGAACAACTGGACTTTATTGACACTAAGAGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACCTGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTAGGTGCTGTCGATTCGGGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTA ++ 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+TGATGTACTTCGTTCAGTACGTATTGCTAAGGGTTAACGAACGACTGGCTGGAATCGACAGCACCTTGAGGAGCCTTGAATACCAAAAGATCACATTGGCACCCGCAATCCTGCCTTTAATGCTGCAATCGTGCTACAACTTCCTCAAAGACAACATTGCCAAAGAGCTTCTACGCAGAGGAGCAGAGGCGGCAGTCAAGCCTCTTCGTTATCATCCGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTGGGGGGAACTTCTCCTGCTAGAATGGCTAGCAATGGCAGTGATGCTGCTCTTGCTTTGCTGCGCTTGACAGTTAGATTCAACGAGGAGGCAAATGTCTGGTAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGTGAAGTGAAGCCTCGGCAAAGAATACGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACAGCCTCTTTTTTCA ++ +#($$$%%,0448=9,(&33;<CDHG@A@78.,66-'&&$#*<951/'(&'+-)/4/1)0.479:;:@DB9**:=>=6-+0-+&089;+&*6=;C>?BAGIDFHI=BAB=?B?7)($$$59780.8=6=::.7'&:25446<>4845./%):@==://1/01BB-(+GBFF)58A=?98.5/*/5:00881453,*&<8:;;>:<;/&%"&%''*%%($,229=1812<;=>;>$&()05;>A;>A@-;42%./2-*(0(+)**&)*''',1*3-/6530%+6;<=-));,+%)'&%%)./+&&68?F7F@7111=6-.'$&%&'+&'$%$%%%$"%(*))'$*%%*+1(+<96-/&'**,-,(68++<34C12>:::?;>=?'68=:>??=@A5=BB;:6)$%&%$$$,''656;;<<0+(1.+$&'&&+,*.6721B1)=9;GE18.78;.788;5079<148674(+('$$$(($$(%$##)(%&&%$$$% +@SRR11410539.1455590 1455590/1 +CAAGTGTACTTCGTTCCAGTTACGTATTGCTAAGGACAAACAGACGACTACAAACGAATCGACAGCACCTAGCCTCATAAAACTCAGGTTCCCCAATACCTTGAAGTATTTATCATTAGTAAGCATAACAGAATACATGTCTAACATGTGTCCTGTTAACTCATCATGCTTTCTTATGTATTGTAAGTACAAATGAAAGACATCAGCATACTCCTGATTAGGATGTTTAGTAAGTGGGTAAGCATCTATAGCTAAAGACACGAACCGTTCAATCATAAGTGTACCATCTGTTTTTACGATATCATCTACAAAACAGCCGGCCCTAGGATTCTTGATGGATCTGGGTAGGGAAGGTACATAATCATCTGCAGCAACATTAACATGTTTGAGAGCAAGAATTCATGAGGTCCTTTAGTAGGTCAGTCTCAGTCCAACTTATTTGCTGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +&%'#)*679;=@=A>%*8;;A=<798444:6+,'5&%+1%;9:;7<8;73956+*&)+009:>?82;8',<*;:>>44@BAG@+38/>;6)000DFD>586864.+*&,..-8969:71444,4+*),7?A4=?99B?>8@;;:>=<AB>8=?D<?>0/%%(*00))$#$%D<><8;=922462)*,1/:79:99+;4088.*/%,.042/2+.6;=H9<6ACF@78,&*(14&@02106</9@;?@F=D<=;EL=:509A>?:42:@+567<845575C@><?9D@FE;A<CA>=:==AB>?@=B8+?AAC64605579>7<0:05453?KHFB28:=;?A955)1%89,-0*3,/8;56:8)'/'%+-%'$$+&%*%%&'..:<2++),%512%*(167+)'%2789?<@EC?+?*D;@5879:==:44;+,)**<DEF657%':79@949ACMB;=:DBK@ADB;<8;@A;@B>88,/,02,0114>943%&&& +@SRR11410539.2193881 2193881/1 +GTTGTACTTTAGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAGATCGACAGCACCTACTACAGTCAGCTTATGTGTCAGCCTATACTGTTCGTCAGGCATTAGTGTCTGATGTTGAGTATACGGAAATGCAGTTAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTAACGACCTGTGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCACATTTAACATCGGCAAGGGTTTGTTATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCGCTTGCATTAGGTGCTGTCGATTCCGTTTGTGATCGTCTGATTTGTGCCGGGATTACGTAACTTA ++ +%%&,((%%&(():;@<<FF18?FDDD40??@-GPHGJC==<2@AACDB>DGC>2.4+;;<@D<8CBC?=8535?:6?=BCA?@@A>?,0,12'=<;B@@@DC?5'&00238733;?@FD>@DHBEC:/8&51'$$3'(+())),*,/5)*/.089792.'-24@@;@>--5:A?BCL:CC?C229999::5,++++*-'(1312+63;<=;=79:95>:?:D67>?5(.$$$)+*)'#'04:45+4268:E@00714<>C=CD<?9:>?1)+%%&$&'%%$&*/.6:2217>>C=257)5:9:9;;0DEBDGD==BD2AECABC3EB=:@<><=720444=>9B1@=:A;0)<0IDA722.4/B;?=8:67<;C?@@C@('&'$%%2:98:8=?@/+,-5+4017CB=87@ADEJH:95;>;89GJCB?HEB2822((1*/'&,,#$+,1/47C<=A@>BA@=@;>?D=A8*'$&')&:/52757,$###(*)%+29>8765%%,% +@SRR11410539.2322211 2322211/1 +GTTGTACTTCGTTCAGTTACGTATTGTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTAGCGGCCTTCTGTAAAACACGCACAGAATTTTAAGAACAGTTTCAAGTGCGGGAGAAAATTGATCAACAACACGAAGCGACTCTGATGCAAATGCATGAGGACTCAGTATTGATTTCTGTTCTCAGTATTCAGGCACCTTTTTTAGCTTTTCCTTTTTGTAACTTTAAAATTACCACAGAGTTCATTGTTTGTTTGAATGCTTTACCAATCAAACCTTTCACAGTTTCCACAAAAGCACTTGTAAGGAAGCAGAAAAAAGATGCCAAAAATAATGGCGATCTCTTCATTAAGTTTAAAGTCACCAACAATATTGATGTTGACTTTCTCTTTTGGGTATTTCAAGAAGGTTGTCATTAAGACCTTGAACCTTCTCCAACAACACCAGCAATACGTAAC ++ +(+,+,(%%*@@G1-&85686.?89:(&&'4=EE=?58:7932/,*(-/238365?=ABHCFAAG@?F>C4C*29>:;8,-/?BGFC><9;6798/&&)%%#&%(%,$'2B4A2.&;164<,:)539..3-,+,#$$(()63,+%*.''08??@>D?EFGH211-(#%'+%%*)($(&,,+&'+1.)&*+$$&,(47<,9:;BAE??DDHD;4-5<===G<=CAFDE>;3.)=@>HN;3254567206$(%+&&#%)&)A7@BA22;822794/$$((%58;@4814<7987>AA@1408:;3.$.(&&&%+##'$-)-))(+*@53)&3$$%)7965A=7CD1271<=@246<@BGH==8=?801$>?BFAA755<AAE>DA:;81?A>AFD?>F@G>>5,)43:?C/?$%/2,4>;/,25;>@3332&%$$*#078787:,970+;<2@@:F0@DEE?CC>+/& +@SRR11410539.881123 881123/1 +CAGTAACCTTCGTTCCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCGGAATCGACAGCACCTAGCAGCATCTACAACAAGCACGAAAGATAATACAGTTGAATTGGCGAGCACTTCTGTTGCATTACCAGCTTGTAGACGTACTGTGGCAGCTAAACTACCAAGTACCATACCTCTTTAGGTTGTTTTAAATCCTTTAAATAAAATATCATCTTACTTTAGGACCTTTAGGTGTGTCTGTAACAAACCTACAAGGTGGTTCCAGTTCTGTATAGATAGTACCAGTTCCATCCTCTTAGGGAAGTCTAGCCCATTTCAATCCTGTAAATCGGATAACAGTGCAAGTACAAACCTACCTCCCTTTGTTGTGTTGTAGTAAGCCCCAACGCATTGTCATCAGTGCAAACCAGGTTTGTGTAGTACCGGCAGCACAAGACATCTGTCGTAAGGTGCTGTCGATTCCGTTTATGTCGTCTGTTTAGCCTTAACTACGTAT ++ +(&%+#$#$#%(3?<*11799..'+,,1088$%.A@;;>;7..4(1&79-,*-&/369:9;>EBBAC@?93-05134;;B.%4++/**&,)-&&:'-EHCDGE@<?NH777=?689-,A>;<?AC=4AA773583>CCI=>G31461-)26<=55+-*)%+7;<;;:56?34.=5BB:10&+.568117;@B=B9969:<;=?@F776&$++*&'&%%*%%#$$#'+95><=7223-.3*+6-8'):38?B@8GHEC@=:=78<AADC>6<:@=1<9/*:9@4B28+.*67?>=;027''0+;>7,3//%)$16*+',5.+)*.-37''*-,628?9C=AAC=?746C=A%&)==5576;;0*:8;5;$$&<(EA<787.+$%$*'(01%%$$%(.85:===@)&?7A@<444.'+&++'(B:A;:316567;<.(;=3079@E=76D4>>9=<&&.;D@DEC>@>;8=;=>FD+#%%05=>G>@88,'%$&$&%&&&$+$%#% +@SRR11410539.2128799 2128799/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTCCTTTATCAGAACCAGCACCAAAATGTACTTAACTCTCATAAACAGGGTACAGCTAATGTTAATGTGTTTAAATATTGACACAGTTGAGTATATTTTGCGACGTCATCATTATGCCTTTAGGTAATGTTGCACTATCACCACATTTGAAGGTCACACTTTCTAATAGCATTCTTTGCATTTTGTAAAGATTAGGCATAGCAACACCCGGTTGCCACGCTTGACTAGATTGTAATTTTGGGTAAAATGTTTCTACATGGCCATCTTTACACCAAAGCATAAATGAAATTTCTGTATAGTCAATAGTCACTTTGACAACCTTAGAAACTACAGATAAATCTTGGGATTTTATTATTTCAACAAAATCATCAAACAATAAATCAATAACAGAACACACACACTTAGATGAACCTGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAACAATAATAAC ++ +$%%&-2/;B;=>F270:FD@<9CB>D@@>-.?@HCBD11()/6999:4.::31&)%+-65:24/74179).:==EC*&;>7?DD?N:GIFAGFIK?@:;''(;=66&(+&(+,*(/%%%+&-111657>AA>35/0@<;<@8;;9DBA26,6ACEG=8-2;AGEC>CD::32.(03767232-0077890*10-:<56@B@BG@B72920/$''$'+--9-9399:>8886?49@1B=BDGDAGJI@CA@BPH>;47867600*6=B<:9998>ABCA.5?FEBF4A56;::;5255-1:77===AIGEBJ==E@E:<89>?8:<E?<<<>C=?DB16=20AHIJB<:::=2*B6<A3;B@=?;B<@;8>DF?C5.;=33BCDA=B@7:8=FCE??=@B>>;FA>CH>??;8;<:FHHHACB@GDEB,-7==A@;>1+>.0'+058<=?;A<<;><9<760.9$4&/47565:39977<<<?B3?2@;<<G@:<<?AA675<=542,+04423-<=96=><;>>)'&&&$$%$&*' +@SRR11410539.2374698 2374698/1 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+CATTATGCTTCGTTCAGTTACGTATTGCTAAGGTTCAAACAGACGACTACAAACGGAATCGAGCAGCACCTATTCTACACTCCAGGGACCACCTGGTACTGATAAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAAGACATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACATAAGGCGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCGAATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGCATTAGCGACCCTGCTCAATTACAGGTGCACAATAGATTAGTTTGTAGTCGTCTGTTTAACGTAGCAATACGTAAC ++ +$#&'%%$()))1;:1,=9<.?>?<=B0/A<='646$$&#+)*/,46'%128<?4#&%,%%('$$+-.7@?JEDD?:28--7'72C?DD7,.89:),3--+&$,%&%-;<>?LF591*),+*./0,9@?1A@?9@?=BBCEA:A/487((<;><;>DC?@959EHGBBB::6.449:89>7<@@;@7<:<=B=>56*)0'...3;=?.%%?;C;A@JH@C?FCFIJAAA;+$9$98:<0+))*)%&&*.,=11228F:86<7=447:I@>B>DD?D7<=>304?1>DBC:;@FF<G5GL@=<>C?@99@<CB=FG<?ABFHIBFF@@D@??====><<53,.*&%%$$$$+7?@=>@=2+*+&&(4@B2?>=2236-55998;AEDD?BJ:6-(6BBLM83>CF@<??::?7933/<55113/62;36-+8)/&%((6;:@>?7;)'26473:5:99-;.-*---)*&$+(#*,///8467.7:@@BAA<2/.%$2)045>BB@<,+' +@SRR11410539.54220 54220/1 +AGCTTTTGCTTTTGATTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCAACTTACTCCTACTTGGCGTGTTGTTCTACAGGTTCTAATGTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAGCAACTCATATGAGTGTGACATACCCATTAGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAATTCTCCTCGGCGGGCGTAGTGTAGCTAGATCAATCCATCATTGCCCTGCACTTCATAAATGCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTGTGCCGCACACAAATTTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCCGGCTGAATAAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTT ++ +&&'('%&#(,,,+)((+/*38;5B>D?GF8>@>?,@DDBFG7>6:6@A>B;@??2+/2369=9E=F<CE>?/@;<=??'&B:=81<=A9=9443&'$35;>>@;BGMB@BDE@DBBJ35ABB5.1+D>??BGEICEC=BC5<2@HDA@44::<543+0$'007;?@B>/4)0=7CEF?=77KIF?B2%*6-../==;9;:==CB<BEAA/%?77A<8?7791/,)&3/./&,(0#$2%))($)*4?>307=26+$$7-4447:8;9;>;=<0/%('&&)%))&'&$"&$$&'/01-482>=>@=6945@?'&=B89/C.61*..5966%>,21###%%'%*-57876//20/./(A9CBA>>0)1)65;BAEHBJF>ADC@B?EI@@D-8.A=-+252789115=?>@??<06;BABBA,/36>45==$.%'*)*$%)()).>B55GEGHB78:66:;<;1-*%)*9>>A>ICB>C@A'ACDA?@=CCEKB'468;>6>44640;?>?>@;5700.,)))9;;=:;910%%' +@SRR11410539.1110144 1110144/1 +ATCATTATTACTTCGTTCGTACGTATTGCTAAGGTTAAGCAGACGACTAATATCGACAACTTTTAGCCTCATAAACTCGGGTTCCCAACTACCTTGAAGTGTTATCATTAGTAAGCATAACAGAATACATACATGTGTCCTGTTAACTCATCGCGCTTTCTTATGTGTGTAGTACAAATGAAAGACATCGGCATACTCCCTGATTGGGATGTTTGTGAGTGGGTAGCATCTATAGCTAAAAGACGACCGTTCAATCATAAAGTGTACCATCTGCTGATATCATCCACCAAACAACCTGCGGCCCTAAGTTGATGGATCTGGTACACATAATCATCACCCCTGTTTAACAGCATTATTGTGTTGAGCAAATCATGAGGTCCTTTAGTAAGGTCAGTCTCAGTCCAACGCTTAGGTGGCGATTCCGTTTGTAGTCGTCTGGGTAACATAGCAACCAAC ++ +$#%$"#%#%'&+335:,()2,-)%%$%(+178+EB@9;%/,.-1+)&&$$'(1-908++10001636750/39<<78=(,??<384//%+/1204833<EF;987<&&,+4501+A;:772('$--+-''')-57-7%%'6=24%%,;<;87*$,))-?>GA>972%1)++(''(.02;9(;%&7882:(-4.+))52770/,,,'*84**%$$$&'$30%%%-(),(%'.53635470($)&+('%*-232,.67'%((&#%&&'34:691'$%,+-/-.801++$./3-3*+'&$$'#%/044''.%(7;=7;9881&&/&%+1,*(,02*(3+<;?<3055-'&%/-0473$-1'-($(+%)&&&$#'&&)$+3--5++4107//4802,668+<79**2+)(&$$%*&+0&'&-./2898:9.,0-28<72<5&&$$%*-'46/4$%&&&'$ +@SRR11410539.823019 823019/1 +ATGTTGTACTTCGTTCAGTGCATGTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGTTGACACTGACTTAACAAGCCTTACATTAAGTGGGATTTGTTAAAAATATGACTTCACGAAGAGTTCAACTTCTTTGACCATTATTTTTAAATATTCGGATCGAACATACCACCCAAATTATGCCAACTGTTTGGTTGACAGATATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAAAAATATTTGTTGATGGTCATTCCATTTAGTTTCAGCTGGATACCACTTCAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTACATAGCTCTAGACTTAATTTTAAAGATTACTTGTGTATGCTGCTGACCCTGCCTCTTTGCACTTCGTCAATCTGAGTTTATGGATTTATCACAATAATGAGTCGTCTGTTTAACCTTAGCAATACATGCT ++ +(0112:6**1-23<2)#%1%0(''.+*'&'>DDFG77((1)>>?@6523+3.0-;;9:42.-13:;AF514<5/678</*.09<9/'(()(*&57::-.$4%'9*EFKB;==>042(+%$2351,$%%$,*($#'0'&#(.**0(,)&'$%(*,-++++,)&'&)$)-/,+%#$&&&&'(+,--/0+))$%$##**-,7:;5./%()'&'',&+'(%',;:>?0'95;AB<=>139=7><E2.(,%'6%$$%'.(&%03'.*%#$&-/&&(::?8>@?>=EB<@62<1-:A>44DD?<6:>;9%&($(1.*,/47/)00>0)+%/1+-,%#(*0068()$()'+*:5<:;;+*196324,2/7>=9:@<=.,%#'.-)6?;6145:;<8244765?@.40.-)(((*%,*+*,::3/59;BD=7.((&%$$#%&$#$&$&&%**+.%$$,$&%&)),&*+)$()%&$$$$&*$$08:.(-,6::<67@BAB<9;<<9:3$$$"# +@SRR11410539.1027762 1027762/1 +GATATTACTTCGATTTCAGTTACGTATTGCAGGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCATCTGGAGATGCCACAACTGCTTATGCTGGCCAGTGTTTTTAACATTTGTCCAAGCTGTCACGGCCAATGTTAATGCACTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTGCGGTGTCTCTATAAAATAGATGTTGACACAGACTTTTGTGAATGAGTTTCGCATATTTGCGTAAACATTTCTCGTGATGATACTATCTGACGATGCTGTTGTGTGTTTTAAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACGGAATGCTGTCGATTCCGTTGTAGTCGTCTGGGCGCAGCAGCCAACGTATCAA ++ +&#&&&*&,,.&'$8==><<GDCA?B@98%#%'('$&?B@@11AACHCDBEBE;><@FH@B>C4<.,-/199(&.&(.9770&/1-477786++/.*(%)#%$%%&--3?HE@A?<99:?<&&;???AC>8/-,*+62<?;>AA=>,,)(,00384;78//<=<+166:<EE7GAE@@?@C@5649:8:446-3:<:?GA>62:+)','446.2-/9<88+6(&&*++%%'&//,,1>:@6==:80C;66(;B95:22A?@,*15=>=FB@61089:187::/4*('4451--+&$$#(+%+(../832?3@C18237778'-.*'(*+&'(,46988686>22.=?D685GAEAC??F76FKB:6@ANKA--,1,&*6/0=HHDCED>:=797&0('$&.;EC99<>;<@E<=+7;<2A89<>ADE?CFBB?<:C=@AIB9C@HJ.&75%+(())//1HJSMABK@7C::=*-***+595:?BDJC5:;FD5/8504::;5,,)$&&$%%$%#$#$'(%%+-$% +@SRR11410539.1372458 1372458/1 +CAGTATTGCTTCGTTAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTAGGTCTTCCTGCCATGTTGAGTGAGAGCGGTGAACCAAGACGCAGTATTATTGGGTAAACCTTGGGGCCGACGTTGTTTTTGATCGCGCCCCACTGCGTTCTCCCATTCTGGTTACTGCCAGTTGAATCTGAGGGTCCACCAAACGTAATGCGGGGTGCATTTTCGCTGATTTTGGGGTCCATTATCCAGACATTTTAGTTTGTTCGTTTAGATGAAATCTAAAAACAACACGAACGTCATGATATATAAAAAGTCTTCATAGAACGAACAACGCACTACAAGACTACCAATTTAGGTTCCTGGCAATTAATTGTAAAAGGTAAACGGAAACTGTATAATTACCGATATCGATGTACTGAATGGGTGATTTAGAACCAGCCTCAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +)$,()#$'036@:B=496:H=:1FEG><<'(1EHFJL><457??:<C@9@@3,&(-136C?/@(?@B?756C<>@;'(.3:=ECHC7*)8:44):;=8>BAA=/<5798253/35./.**/)-<@@B63702-.F@DCBD8@DD:59;96B=:E6,1-***798)56:<;<:>?5=@GFADC@BCF?EDCGA>;6:78:>A44>;?BA<AAC;7344442;(.B?CBG@BCG37/.07);;H?/46=223/-1?&&5*+28AC@E1(0>?G?CABCJI>>9>ADELB:;7CF?77934717//5538:76324%$$+23755:<=GCC63821-4)*/7++,./:;<*)>?5=@;0/1GECJGDBB>>79GE>:>>?ABBADC?BF5,(30=?9:$'322;>C<<D:;:?@LE@BD:5@?>B84249DBFA38G>GDFF6=-/8=4:-@@9:))7,C@A>?<AGESFDG=@;B403/<@;9DAAGBB=>AB@<8=A@?;7@=>87%% +@SRR11410539.1731916 1731916/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTAAACAGACGACTACAAACGGAATCGACAGCACCTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTGGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTGTATGAAAATGCCTTTTTACCTTTGCTATAGGTATTATTGCTATGTCTGCTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTGGTTTATCTAGTTCGCTAAAAGACGTAATTATGTATGCATCAACTGTGTGTTACCATCACTGCGGCAGCAAGACAATATAATATTAATTACTAGAGTGTGGACAGGTGCGCAATCGAGTTCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCGTGAAAAGAAAGCT ++ +&*,7<:=?;;6D3;5?FC?AB@FDF54;-,-).=@F?DAD?EI=BC>AC<3,0.986486<1?>EEE@BA6@@A=:9/1+2<KI43301@CB<CC@A>CVGD@88888&+?@A<:;//6@-/87;A9A?<A@C:;FB0:?@<QHSGED@BD>=AB=FBFCBIGMF?98;GEDADKC408::425//3;<@<;;8;))%&(=5>22,/(9778D709341.6968+68;:B@=>A;90*-%-7>=CBC<=;6=<;=AE>EA=@??18<55=>???ECK<..846),;?AD7A<54.((/1/74769?HHGDAB@63*+;AFB@9A<?GF>?=854%,?2.$,+/3+2>@*)29+'+,/()69EJ2%(54'*(*)-/(++.%$4/6;$$++%,'%%+-($(*%-##''-$%.,$4,-'%%#$%')$'#%#%&++,%$&$'',...26=7-4:2%#$$**(&%#'4);5D@J66B:5/);?9<45B989789201//$$,'+&%$$##''')$$ +@SRR11410539.1635244 1635244/1 +GCATTGTACTTCGTTCGGTTACGTATTGCTAAGGTTAAACGAACGACTACAAACGGAATCGACAGCACCTCGGTATGAGGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGGAAGATTTTCAAGAAAACTGTTCACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTAATGACTTAACAGGAGGGCATACACTCGCTATGTCGATAACAGCTTCTGTGGCCCTGATGGCTGCCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGGTAAGCTTCATGCACTTTGTCCGAACGCAACTGGACTATTGACATAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACCTGGAACGTTCTGAAAAACTATGAATTACGGACACCTTAGGTGCTGTCGATTCCGTTTGTGATTCGTCTGTTTAACCTTAGCAATGCGTAACT ++ +*.*,2371=BB@>Q9A&-6:7?=;;::;6;221CEA?A81*(*1.)*007CEC</2FBB9DH<B5CA=?3>775%%,*'?@B:=A==:9998=>8(($(5+;<>7.C3HL96=GAEEAA?BDCBEA:>;<443///-16>@AB@&&.&.>>/13'&49<=77+,+084-*,+$$%)'+2344/5?.;9::89AF=?>65?>BC<D?C;/.,'$&$%&%(&''56)%0((27;>5:?C?CEB>>:==A64))'*+&*$$$&/3464:DBB986>8;5.';=9;??06(=;:4766IJ><G<>B6>*,//15<G<;@.091+-%67=?=>ADB=@B@8$$86/0&%0,-;??@($@>A@E;/--,.'97A8ABCDDAB@F>;9;;=<DDCD<13421>?6>/6+56/...1241$($6:7@DAHBA8<773,)25907---+%/,0-*9@?>9=1@9<:B>>ABBB@?B8=9;1,*$&%**2>6;IID@?,/+,25878%%;<8531( +@SRR11410539.2351902 2351902/1 +CAGTGACCCGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAAAACTTACAAAGATTATCTAGCTAGTGGGGACAACCAATCACTAATTGTGTTAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCCATAGATCATCCAAATCTAAGTTTTGTGACTTAAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTACACTTAAAAACACAGTCTGTACCGTCTACGGTATGTGGGAGAAGGTTAAGATTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTTAACACTTAGCAACTCTTAA ++ +.*0534421&/1)12=>;67A?.:779?C<A@989?7>?BD?<884.--,'-2331(,1888=A0-<?B@?=?12A5<36AB8,&=)@==>>==;96.:66=<<581003CB>?B@E@A?:=>::@EABD?A84:DEG=B9:88==II32ECAE@?A:@AA@:<=6.-'78:7;78),8?A94B20@??25;36?BG;>>A?>>;>:>6797@@FDF4?,;E=EF8FA>F(@9B:103685::;7;=A8:A;>66>?=56@?</=6<5:)1D?@BA>@:;>.'69.8B669;<4',237@CE<6,&8,<>-8:430+8<>8859((,,*53<147=9''?550)9&%4>27JD?DDD;<9ACF-',-*'(*=<3302:BBBBBBA@=@:7'(+'$%'001<EBIJ=;6?;;:;?A=>7778HI=C?;=<8<57.-.878=88-,C8@FB>@=99+6(/;&H46*+.'&,<>BA?BA<??2A=GBG:?AA<;:;>A==<>6.,.%##%)%''&#'##$## +@SRR11410539.1038477 1038477/1 +CGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCAAATCGACAGCACCTTCAGGTGATGGCACAACAAGTCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGCTGGATGCTGTCGATTCCGTTTGGCAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +'#$$558/6DA3):8=A:?HGDEBBF>>-FFBAD@=./;6@>>=<:;:(,',9>@>@>E?EE?@B>9;88@769:816>22://+&?+EB?9A677>?FCCDA=A=?EFD<=:=>/1<@3..;@D;AIFC?9;;<8<?@8/7/-0:57A;=>F@JMD:7666;151CBA8<<;;=4552A1E@B??=4EDHBB:>CA@/>::@/@&&&(.--4+?;;C>86:7;>@BA:>D@A@E?<A=<?>9BC?DAC?;;CDA:<;?AEBAAB=ABAJBA:999%)/&+:>@;<A@@2@4</;:DIG=BC=I>BLICA-.E683@FI@II?A''46.79<@GGHF5>;;;;9,577CADH?>BDE@@>AE=@C=21(-7DC:>;HK<;45=6<<:?<==><<;4.<;@::B=?@@<=:59??<>?;6:<07$($$$%%$7643<?E:>D@:=;FA>=@D@>C??41<=>BDAB=030-'$$%5:0/&&$&*-$64;5:9BECHEBD<D@>-&%%&8@>>AA?@?=''=B;=C??>>)6=96'1# +@SRR11410539.1390629 1390629/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTGTTTTACAGGTTCGCGACGTGCTCGTACGACAACTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAACCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCGTAGTGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAGCCGATGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +%*+24.;>?CCH=>4AED@@?B>>>74/2(BQDAC2=>>@=>994553437/0.7<<A@**2;:244=8,89:70;:ABLCF640--);)')%$&%/,&,))&2567077:%60=6;>H4)1/&118?:??9116:/53:;78EF>BC@LNFCAF><50(69:=EHDMGDADE@?ADD=??2M>%1*&<FAJD<>>53&'$$%(&(1%%>?A@@:<DDFE?:88-26<>?0+(,;:)'*9+,3;>AA5@B@<69@E;31:>89AB:<F<80D==02>@CB>?:986-&&%&*'$$$%%(,$)7<?BA??9<07:81232/5:=56;7:<;=B=<9?877;>9+%''+0.&$''-//-,*06,-3?H<===?BDCB>++-2/-,5:9??8J.0A1<>;99>443/-57<:<;=33:?CBEB8:>AB9<8@=@A6,*<=;377=C@34(.../056(*:;7''.(,&'.5===@61D@?AC?A?JDK@@>@:@-):CB@BFEHDA@;633=?CJDE<52% +@SRR11410539.921407 921407/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACCGAACGACTACAAGCAGATCGACAGCACCTGGTGTTGTTGGAGAAAGAGTTGAAAGATATGGCGACAGCAACCTGTAGAAATACTCCAAAGAAAGAATCAACATCAATATTATTAGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTTCTGCTTCCTAAGATGCTTTTGTACAAACTGTGAGAAAGGTTTGGATTATAAAGCATTCAAACAAAATTGTTGAATCCTGGTAATTTTAAATTCTGAAAGGAGAAGAAGCTAAAAGGTGCGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTGTTATTTGCATCGAGGCTGCTCGTGTTGCTGATCAAATTTTCTCCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAAGGCCCTTCTGGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTCAACATAGCAATACGTAACTT ++ +$$+-59655379B*0(28>A117578/0945.@9:784&,**.-0//--013&.))//08;+$..,--1799:041/0-./(64,$$$%&#$%%*&'')$$$%,(.&0)*227.*%%1?>;:58'0/-+&0*&'+&$6$'+%%$%%*)-+%.%&$*)&()/6@CD>@=:;924?*8:<<=8:;?AA6:<DB75573=?>A>>87+-.10,-+$%&%&&&/0//*%#'+++&0-1..&))(**&7:475F:4;>@A5<CC6:BC>;<3645:9<?99?3350.1>A@@F@8+($&)&&&(-'+10/+0)$)*((12.$+980*352:GGI@<>@ABA04,-2.23467400124**2(*%&#&%+,/12;0.-'$&'00++--,/-(+(&')&''%''-/-+2+%*&%)**,*&++(:3@BD>>;>>=8:094;8DCDEK816..1+%)3-,##'''&(*>;=BA>AC?KC?@9?@D=<?89.(&'&$&&&(**1).%==>91/-'%12&&& +@SRR11410539.1934526 1934526/1 +GTTATTACTTCGATTTCAGTTACATTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGTGTACTCTATAAGTTTGATGGTGTGTAACAGATGTTCTTTGCACTAAAAACTCTAGGTAAGAAATGCAAAAGTCACCATTAGTTGTATTACAGTAATATCGTGCCAGGCAAACCAGGCACGACAAAACCCTTCTCTTTATGACTGCAGCAATCAATGGGCAAGCTTTGTCTGTTATATGTACACCACGCTGGCTAAACCATGTCCAAAATCAGCATGTTTGTTAGCCAAAACAAGTATCTGTAGATGCTATGTCACGAGTGACACCACCATCAATAACCTTGTATCCTATATGATTTCACTTGAAAAGTCAGTATGTTTAGACATGACATGAACAGGTGTTATTAAATAGAAAATAGCAGCAACAAAGGAACACAAGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGCAATAACC ++ +&%%'%*6888+0+?E(<8;:>@=**.95:ACH:;9DLIDG@=449;=9?@6;<?9>8:<:===B<@7DCDC>>9E>:8?9:A<CAC><:8B?<==999-*))+41:322/**,7%+115:<DFD?3?.D;AA:<2A9743;12''(<@7<:211(/.0%&$$'%&%%&(($+51+1.//-('<348@8479:9876757+.0*$$6;>@A?1689;<A=/(:BE?5A79:2443452<ACD*$-%#(-0,,%#''+9;<D@=;>45538;.89:50&&?:<>1+14*.,0/=?G>C::1,21409B=>>H)&+::>>>ED:ABG=<5=4.%$*000:1AA@=?6-A775$%/014>AE78;K@*:BEBADFFF?BC=AO@8;:@59EF??D<>==?<;>@@@--5560/33E?LOKNJHIG>76;2@E?721<('8>776(*C?@B97,-+;8;3?9><;929ACD@B9FEI93C7:7.9<::=@5((&'&(6''''))2%&&'(%% +@SRR11410539.1424426 1424426/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAAACAACACCTAATTTGGAAGAAGCTGCTCGGTATGAGATCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAACACCTGAAGAACATTTTGTGAAACCATCTCACTTGCTGGTTCCTATAAAAGATTGGTCCTATTCTGGTTAATCTACACAACTAGGTATAAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCTACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGGTAACATTAACCTCCACACGCAAAGTTGTGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTGGCCTTAACTAATAAC ++ +&($&&*'(/012<9,'87>DDEGGEE10C34/9<DGH=96;69(('),,./%'$&((%.$%.2?A@DC@IE/0AE'((4??;;2=678<-/19::A-;CB6ACA=>A?CDF>9A@==<=?==FBIF@E?>CB@876;?BDD??7<68==<=?8=1:=;@A71:;<<GD5D+8(),7>;?<>>>5(AFC>@BEE$698AA;::76=?75886<=9:AA/0ABAFK5%,--1%'''*(;@<70%)04=@=B<0,//)*:6C<=8>>%(5EEI>D<)+;6&,65=//3:>>@6C741,,,017?</%-99978),===>3410,4;:<<9;/6-+:97?DGG@?>?CAFB;A=>FB:;>A=B55C:>9@?E=@:87.///3858=7.))%.3)*4600;>C:A01,)6-0/$%25?:;;2367::?==<3&524/0795-24@<>?;7C>:FF:;0::IA:;9796<A;::4$$#$#'(($$%%%&&# +@SRR11410539.603810 603810/1 +CATTAATACTTCGGTTCGGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCATTGGCGCTGGACTGTGCCTGATTTTATTAAGCCAGATATATTACGCGTATACGCCAACAGGTGAACGCTTGCATAAGCTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTGCTGACATTAGATAATCAAGTCTCAATGGTAGCTGGTATGATTTCGGTGATTTCATACAAGCCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTCATTGTTAATGCCTATATTAACTGACCAGGGCTTCTTTGCAGTCATGTTGTACTGACAACAAAGCCTTGATATAAATGAGGTTGTTAAAATATGACTTCCTGGAAGAGAGGTTAAAACTCTTTGACCGTTGATACCCTAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTTAGCAATACGTAACT ++ +$'#%$$*'#)*'%)8.<)1/5<B<DEFF>==))2AB9'('%%*%(.+-+)*0225485950$$$%''#$%$*2,,("#$%&+*147*%$%$%&/5//:B=87=<79=<AC;66@331&%%&(7<:92,(##%'*&&./&+,28,/7876-*1%.*07:69>567<8:2327,+-&'.12.)/07DC><>==>;552'95A@B?F<43;88:57%&&224><=B36+=%11<AABBCAJF1*,3;>?BADE:74445'*)/<;;;9B<474=453;=8-/15?@98?5DHCCD;11+/48:7798;;:?>5(&&,0))%),+(--=:;111'').)'(&0-10045++114845-.6;<;2563.+*+)(%&#%&$&,(-996=@?;5357-$/0%'%$%4600111?:;?@C8;=976.2(*.065-,1021+&#$('1756:B?@>9:<CBD=5<41-''&&(1:5-.$&#$.'('+)&&;@?62(+ +@SRR11410539.2117172 2117172/1 +CGGTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACTTTGACTACAAACGGAATCGACAGCACCTGTGAAAGTTCTTTTCTTGTGCAGGGACATAAGTCATGCAAGAAGACTACACCATGAGGTGCTGACTGAGGAAGGACACAGATGATAGCCCTTTCCACAAAAATCAACTCTTTTGATTGTCCAAGTACACACTCTGACATTTAGTAGCAGCAAGATTAGCAGAAGCTCTGGTTCTGCAGCTCTAATTGTTGAGTCACATATGTCTGCAAACTTTGAAGTCTGCCTGTGATCAACCTATCAATTTACACTTCAGCCTCAACTTTGTGAACGTGAAAGGACTATCATTTAAAACACTTGAAATTGCACCAAAGTGTAGACTAAGTTGTTTAACAAGCGTGTTTAAAGCTTGTGCATTTTGGTTGACCACATCTTGAAGTTTTAAATTTGCAGGTGCTGTCGGTCCGTTTGTGATCGTCTGTTTAACTAACAATAACTTA ++ +.$&%'&+59<@=GA*,%/601:C>BE<;5/0;EMKGKE.0+*%%%%>B9BDBHL=A373;8=BHBBEGF@@G>AB>856==?@>>78FGCHFCHFFKCB8578536,,+3..-5/@=4449;A@@:<9>?B>;FIG:8:34.''')*%*,22<965/(3:6337='*16GHDC>0B<>9=9CAC6=9:?8//A))+EC/=CCFBB<BB@BIJ93.+$*&+%1368?HD?6,B0=;6>:)&#&+1*78:5:D,?/*('.4560+B8<9;;==92&A,>ACE<FQN?=74:7<>CBAIABD5.C77@@:726$&$$(##%#$(*),44,?99:;H<()%$*&%%%(+)(8,(/:<AAEECDGA@<?<>>@;;66@5)--<FHA6@6$$($76-.3/4<<:7898??5>8D>9:CEGC=ABA+C:<=@:85)-,1<=996=6>DB0+&%/');0//.156*0,50=;:::67().-17?=>&'&%%&*7)<=;;80,$'%%%((&$&+,+$ +@SRR11410539.1221028 1221028/1 +CGGTAATACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAGCGGAGAATCCGGCAACACCTTGGAAAAGAAAGGTAAGAACAAGTCCTGAGTTGAATGTAAACTGAGGATCTAACTTTGTCGGGGTAATAAACACCACGTGTGAAAAGAATTATTGCTATACGGGGAGTGGCAGTGAGTTCTGGTTGTAAGATTAACACTGACTAGAGACTAGTGGCAATAAAACAAGAAAAACAAACATTGTTCGTTTAGTTTATTGTTTCAGAACATCACTAGAAACTAACAACTCTGTTGTTTTCTCTAATTATAAGTCTACCTTTACTAAGAAGAGATAAAATCATATCATTGATTTGACCTTCTTTTAAAAGACATAACAGCAGTACCCCTTAATTTAAGGGAAATTTACTCATGTCAAATAAAGAATAGGAAGACAACTGAATTGGATTTGTAGGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +2$&*%&)*/3:9:@7)*-9;<==GHFH@??+(236:67012389CA<?>?<=)2)-0/2:$$5$&8/0;>CCEE?A;@F'1C>41>;)).1)1+,.006989?D>;:?>;3)(%$',*<@=33((+-69C60;./+9136757;9?@A=A<A?;77;9%))*')%%'#$$%&&*%*)('(1$$%('794DFD):69695,00'==>AA./#'DGB09*(2)8887A<BE=?<ACE>5237;339.+.00>??@@A@?9C?1./%+,'*+%$&%'))*>@A>CB==F@AD=599;;;<?DBC=CC=E?C?7/C*=?>=7635055+87=?@@0<:,,1((,*::<@CBB:A:BA@@77=BCIHEDA;?@E6OIN>DF-%,2123559673;8;9BAD;8BCECI@860(',478=C76;6>==9>@A=;BH220:9=;@*6DAB83.:<997<8;4:AF;.5+.8B:AB=8=A==>AC?HDL?9149949=:>?=122&)&'2%056=??553,& +@SRR11410539.811643 811643/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACCGATGGAAATCGACAGCACCTATTCTACACTCCAGGGGACCACCTGGTACTGGTAAGTCATTTATATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTTGCTCTCATGCCGCTGTTGATGCGCTATGTGAGGAAAGGCGATAAAATGTTGCCTATAGATAAATGTGGTAAATTATACCTGCGATATGCTCGTGTAGAGATGTTTTTGATAAATTCAAGTGAATTCAACATTAGGAACGAGGTATGTCTTTTTTGTGCACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGTGGCCACAAATTATGATTGAGGTGTTGTCAGTAGCGGATTACGTGCTAAGCACTAATATTGTACATTGGCGACCCTGCTCAATTACAATTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCGCCAGCGGCTACGT ++ +&(*00-46>><D52.00756:<56;;?@<;39JB?B@;::??:53470,)$$%&))(-0>>>9A@8B;:=<<;/24-$4,=993441./-.%+8;>FJI;<51-&8@8330&*/)1,6>4877?<)5(,'''/;=77?EDBBH==?A,8&7%(#($&$%,--((,54:<8:BDF88CA9:94840%#%%$$+04(533$+(-'(9=A@D%%ED<==?<>7:;6*-88=<168+*%*005.++;((%#)'$'()/(7+(&.%*'96?><;9CGF@>=KDD622=862GJF@@B442&-,%-,*'%1=72445<<CA=<.%$$%'32.01-'$,,-,%.)47:@>:551/&%$$C>?73@?BC88ABC@?+8%%-.1)789%%%&$$$,124@AE=12(?<7+3:<>=>7/1)'(&&'%*)55&%$&'').003**+'+''&'$+6>74<8=<<DDE@A8=0;%%%($&##%'-<:56956<<),,57=20<4;?9:B9>GF<54*+%&&*$%#$%)12&$ +@SRR11410539.1713855 1713855/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAGCAGACGACTACAAAACGGAATCGACAGCACCTTGTTAAGCGTATTTGACTGGACTAGTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTCTGGCCTCAAGCTGATGTAGAATGATGGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGGTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGATTTGTGATGGTGGCAGTTTGTAGGTGCTGTCGATTCCGGTTTGTAGTCGTCTACTAACCTTAGCAATAC ++ +$$237:6>AC?AQ591<FFHCBIKEF?AD886DKF<=/4;6DCFC=@?=;>==7689B?<?D@@A>CFD?GBFD89<*%/'),?A@>B>A,(,'$5=>D?B66:A9=9:9=3372>@//59<FF4:>>DAAAFF>G<=A4+5&--%*@D+9%%39&%A>E7>GI@EA89%>@B=EEEG@E:-67>6C=<>GC,6474:@?>'%&8=.AEF39?BBK90=GIA=?9002+,$'#+*)+-*=<=C?DHFBA.:*0,-*'%'*79:3.8=?DCDE;>@?A8>4*3+CB@B@A95++1=>DFFH;@5:&35:8B4C8EAA=DFCBC=>9'>ED>4A5>CDCED@?B=D?>A>34>;238*:61*@>>345:<DBFCGAC>C?E==:5@A;<BC?>A58/3?A@CE>FEC951/.(.9BDBCB=?66AHBBD=9B?DB5555...499>?B()%6888>A>I=@A984+:.0G<<>A:=66608;86DC7@=AJF<599:8=655,%'*55?AE3'68013,( +@SRR11410539.1547229 1547229/1 +TGTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGGCGACTGGAATCGACAGCACCGCCTTAAGGATCAGTGCCGGCTCTGATCGCCTAAGTCAAATGACTTTAGATCGGCGCCGTAACTATGGCCACCGCGCTCCTTTATTACCGTTCTTACGAAGAAGAACCTTGCGGTAAGCCACTGTTTCGCCCACATGAGGGACAAAGGACACCAAGTGTCTCACCACTACGACCGTACTGAATGCCTTCGAGTTCTTGCACCAGCTCAACCATAGCGCTGATATGAGGTTACGGTTCGAGCATCCGGAGCGTTTGATGAACACATAGGGCTGTTCAAGTTGAGGCAAAACGCCTTTTTCAACTTCTACTAATTGCCATCTTTAAGATGTTGACGTGCCTCTGATAAGACCTCCTCACAGGTCTCCAAAGCCACGTACGAGCACGTCGCGAACCTGTAAAACAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +%**+'+'47;8:@91,8:@B7414=AA;<<=-BJF<>,2-4760/)&$&&(68AA*&<:>3-&66>@@<(D1++'+8--,#%&')#&&:??@A666.7;9<?>D<4ED580)-733:116?A@?73+''&#%(**))7@B9A;A;?583$7:FIDII65:980))-B>=9EG@A=@?=B577=77),-23*++(25751/0151/?>&?BC=00?+,,?;5;EAGCCE<<;44('+34<@BEEE15<<=6-/(:60,$$'()+071?>1-.==4,0$&/*0.*%$-/&$=(,&<*.:;:88AC@'':'(&'8=@@?0/887:9,2203439;59EB=)+*96:+0469::15>?@>?CA-?()226A7B<7+)%(/45@>@IE@./1(5::<>977C@=;4B5559679887:4;)><0)1>;>C0A7999C?+8::77<7778=51=11313.0,-%4756/0-=21=5-<755617=GBD;>AB;=;<AACAB?EJBC@@?8643017<@B/'* +@SRR11410539.781248 781248/1 +CATTATTACTTCGTTCAGTTACGTATTACTAAGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCAGCCCCCTATTAAACATGCACGTGTTTGAAAAACATTAGAACCTGTAGAATAAACACGCAGAGTAGGAGTAAGTTGATCTGCATGAATAGCAACAGGGACTGTGCAGTTAACACCCTGATAAAGAACAGCAACCTGGTTGAAGTATTTGTTCCTGGTGTTATAACACTGACACCACCAAAGAACATGGTGTAATGTCAAAGTCTCAAGTGTCTGTGGATCTGGACCCAGCATCAGTAGTGTCAACAATGTCTCTGCCAAATTGTTGGAAAGGCAGAAACTTTTTGTTAGACTCAGTAAGAACACCTGTGCCTGTTAAACCATTGAAGTTGAAATTGACACATTTGTTTTTAACCAAATTAAGTAGACTTTTTAGGTCCACAAGTTGCTGGAGGTGCTGTCGATTCCGTTGTAGTCGTCTGTTTTAACCTTAGCAATACGTAACA ++ +(%$&'(05:@E@>K1?:=FD?2*75;8/5;%&*&08;9:234.=@BEG@HI?B9?:?::8?658C?<>90/+-'%%%8;36AB>2+'),+32CCDJABDQBC=?445=5=:A@G?8=5:>A@A552/**(''&5502(0446;7:=<9<C+=>EHHG9;67..9=@>?507)@7=:;DBDC>CDAK@CBECF=2<3.5'('(<<D<>95*)24EBCBB(11)*5687=68-*&&*.(7:2+01289689+'/*'(5.0;;=;?@<5=>>)(6;<5$&%9:=@?;>BD>0/),0*&654*5733)+683@6:=,,,2503)1>71,))*1>>G>@A23*+%*=9--@<3@CCE>E8AA=?<C0<6:=45-=B@D;:@/FBAAHE=<:D9CDAGA=:;>=?>9@?;>ID>9?AEDH@>?PEB,-)8&&/.1&''1173?CA?>-%82++//002->E<<>150)+><>D>:@=<J/465?@7?B>785:B;:ABC99:462/*'('')-*%'((+' +@SRR11410539.378820 378820/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTACTACCGGTTGTAGGGAAGCATTGCTACTTAAACCAGCAAATGGTTTAAAAATTACGAAGAGGTTGGCCACACAGATCTAATATGTTGCTTATGTGAACAATTCTAGTCTTACTATTAAGAAACTGTGAATTATCTATAGGTATTGGGATTTAAAACCCTTGCTACTCATGGTTTAGCACAACGGTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAGCTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGGCATAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTATAAGAGTACAAATTCTATAATTAAAGAAACATCTATGCCGACTACTATAGCAAAAGAATACTGTAGGTGCTGTCGATTCCGTTTTATGAGTCGTCTGTTTAACCTTAGCAATACGTAACT ++ +*&))1329:;69L==5:DIHAAIHDE@?988''3;=DFD1212>EJAAE:;<,4$'$.53&%&48=?>=90++%$/#'05/%*(''&#/8,,/)252..5BD;5)%%&*+)&''/236676688+(011--2987*))*34BA@?,&>+)*),%%*/89?@;740&&035615@A=?9=?A<?GBD?891///.*%('$$$+(&)'$$#&&2-05%*8%-..&(-*//*))$/9B@AAC@46:;/%+%%%%&)$%-&+895B<<<A448799FA98=E1.C>>CH;=@<>9943$&+&=IHHED889A@BAGK9CA5;;831*;?9?@;<1*&4747-%245<?BHFICE5BA>HG@?8/.,%,%(%'8<A@B;<9HCFFH?JE6:89;HBDJCCFB:3336,)&$##$'(*()$%*+'<=<BA>D<8-'''*$'EGA.355=B?@>>%%A@?G==7@HD3;-.CD0&(00,++4329.3@AA<4.<=@BE01+.4:+%%$$(8;<6@:7@>500'($&035<=ACJEIB5(+ +@SRR11410539.2197758 2197758/1 +CCGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAGACGGAATCGACAGCACCTTGGTCAGAATAGTGCCATGGAGTGGCACGTTGAGAAAAATGTTAGTTTCTGGATTGAATGACCACATGGAACATACGCGCAAACAGTCTGAAAGAAGTAATGAAGCTGAGTACATCAAACCTACAGACAAGCCATTGCGATAGCAATTCCACCAGTGATCAATTTATTCTGTAAACAGCAGCAAGCACAAAACAAGCTAAAGTTACTGGCCATAACAGCCAAAGGAAAATTAGCAATTATATACAAAAACCTATTCCCTGTTGGCATAGGCAAATTGTAGAAGACAAATCATGTAGAATAGGAAACCTATTACTAGGTTCCATTGTTCAAGGAGCTTTTAAACTCTTCAGCGGTAATAGTACCGTTGGAATCTGCCATGGAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATGGCTT ++ +3+)++22.4245.)3:@@>;7634326%&1986/1*2769BAE><A?::@B04372>AA652?<<96:-/69D47G@E@IDFD<:675:@?A91@:D;9/&..,)8++:2+6EBC=:47++195:*:<@<0D3@AC>84&'096>3@EGB0+-&=)./=2%((*(6:7013-326+(*'+3/9,0$346,)/(60-/.><..10;:A.@()-.-0'('),,-<8,'09;:<?<66:(13(-//,-696:120479;;@=?=??A@<>.158*,:12:;BA@=?=@3<JH1'7*2798-9$%>>;A<9611=78/77526F?@?BFC@DC<<<>>;@<A48;;A68A2A48A@=>>:??;<'2&%A:9:&360412//243.2';8:<C@LH8?@:*+.*)'134:556(3478448*6$%*/0-5%0*;;9=<?BB>:=?8<>:7355=8;5;>95686?D??9?9F8@>>=@52@8;??-3)$$$.0/0//*&&### +@SRR11410539.1225701 1225701/1 +CAGTATGCGCTTCGTTCCCAGTTACGTATTGCTAAGTTAAACAGACGACTACAAACGGAATCGACAGCACCTCTGTTTTACGAGTTCGCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTGGCATCTTAAAGATGGCACTTGGCCCAAAGCGGTAAATTTGAAAAAGGCGTTTGCCTCAACTTGAACAGCCTATGTGTTCATCAGCAATTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCCGAAGAGGCATTCCAGTACGGTCGTAGTGGTGAGACGCGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTTAACTTCGTAAGAACGGTAATAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCCTTAAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTAACCTTAGCAATACAATAGC ++ +,''.'%$##+9<>=E7&*'$)76,.(;;;84.%#$/)-8;8@11;+9697-146*6',24:;<;9C<<8>=AD@??=@/$&&&,3*9%('.*)(&,->:62625/D@A**0?9<?>EAC=EBE@@<74'%.3327>9=65256202++*()5<A=4566+;@:;<,$$%&%#$$#&''('(0),)*..0...*%*(3354/%((-;%&%%%89?9:8A?25**1,*)'&'*%%%('),637:;65;785=>BFEAECD8:=<@:=>@=@?8302%-*((+*''42:52;/@BB'8-,')06DHDG1&805=9A8D:=;;;B>AC8A45,(%%14;::<?;C=<>D@@>;>;2:==:((2<@A?=@>HDGCNE20078:;+DI?<<;*566;==99=;?CIF%0;''')*(-(;>===?>@?>56/BA@5C+3DGHDF@7@8;>42@G9:<AGDCGB:BD=>1032=<<;5:81129700;--200.;CDBC=8ABBG@BD<HELFBB@:<327($/-*+&)%%'*')))&&###$&& +@SRR11410539.312034 312034/1 +CATTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAGCCAGGACGACTACAAACGAATCGACAGCACCTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCCATTTGTATTTCTAAACATTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTTGAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACTAACCAGCAATACGTAAT ++ +%#$$1:8>DEA>IH05+(/23-67%+5=;88)HG@><.7?8:3+.1.4,&(353++*982>E;E4<=CB@C>DEBBGBB:5:3//0,'99@E@@BFF@:6//-..88:5.++#&$-:;>=?A>@DD+0776@A@@@CDG@AC=><CAIE5/6=A<;;ACGAB=@,,@7=;F<>;8-'(-+79<8679.>=''+>?ACEEIB>:<A@?@7<@0=>H>;:>268DA>@?@C?=>B@@@27CCEFG9;=?B>?@@A?6>9;=>@B;IA9=B@A:<78=B66@=>;@=344=D@,,<9@DKBHF?='7&')%70406'75:79GE?FB93CECCBC@F<;IQ@2?CB<>0AABD;=IFB>F?3328;<GE?=@?67,1,.331188=>B:'DJGH88E8?5(&;?BEMK;>C=?9;882(4<F?CFA;A6==@<BF>ADEB?H@?=%%($$8ABCEC<BDFLG?2%8;L@AG@;3*;@>BCB@86*$$%#$001;=?@D<9-1& +@SRR11410539.853615 853615/1 +GTTGTACTTCGTTCAGTTACGGCCTTATTGCTAAACAGACGACCTACAAAAACGGAATCGACAGCACCTAGCCTCATAAAACTCAGGTTCCCAATACCTTGAAGTGTTATCATTAGTAAGCATAACAGAATACATGTCTAACATGTGTCCTGTTAACTCATCATGTAGCTTTCATATGTATTGTAAGTACAAATGAAAGACATCAGCATACTCCTGATTAGGATGTTTAGTAAGTGGGTAAGCATCTATAGCTAAAGACACGAACCGTTCAATCATAAGTGTACCTGCATCTGTTTTTACGATATCATCTACAAAACAGCCGGCCCCTAAGTTCTTGATGGATCTGGGTAAGGAAGGTACACATAATCATCACCCTGTTTAACTAGCATTGTATGTTGAGGCAAAATTCATGAGGTCCTTTAGTAGGTCAGTCTCAGTCCAACATTTTGCTAGAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACATGTA ++ +$$$',+11102361-<94+3'(%$'.,,1652:>)($)$--/(%(/3575938264>;9>E<8A8>BB/)<78'>*6>@ED@+ACDIMF56BFIEA?@ID=<77=:>@B=C?D?45=B@;=CCAB5:415//69;>=>?@BG?9:;9&&)*)$+36580>;;F<<1B19;<9*#)99<EAAFA8-.7:7BFHE5>@I324;(%8%%%5314@9=?<88=7CE>FGHHC>;50/%@94CBFD;DCCACC<8EE@893)02:=547<>>FACCF>@2:67/=:832/'(38?BC>DADB;7688BD>>?:=0)268@D<<::403-*((+'(3'0BJHFCA<=E7<B@:@9&'.@7@CA;;3DC5;DE=D989=BAAG<JHF@BB>C89<CEC?C<?ABF(+-5567?9>>2311/?4599=96+(7+A9A;>:;6A<>,,A9:ABKJUMBA>=:%7B;<<40><:8<68<@=JBDD@:?<>@=A>>812/2/1)23/*&%$(%$"% +@SRR11410539.152875 152875/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAATGGAATCGACAGCACCTACTTTTGAAGAAGCTGCGCTGTGCACCAACTTTTTGTTAAATAAAGAAATGTATCTAAGGATTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAATTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAGAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGGTGCTGTCATTCCGTTTGTAGTCGTCTCTATTTAACATGGCAATACATGTTT ++ +)/0696<=>?@M972?IEB@8987;-:7//'7-7DHJ8D9C@BB><55//+&$''3>@AHECIJBFDB>8=BG;532/32'<@8B88<.D;:425$$&./;<@BHEACE>EH:+11@<>CD?C=??%?+EKEDDBG?B9;@(><@@9971&$.<F@<<;:CHDDB:=,5)(8;9:=C<CD@AAA@@850;<>>==::=GHFEK=&&&)7:78@@DCBDFA?>458?F<=<>8D5A<?=4:@;;DD>BEE?@=;>A>55./,.054$:AABFH/(,,?7:712A9@==CGE>BBCEGH<DIGB9EC88DB=<865;=0;;2:3A:<;<<:@E<??B@:IE==B<2E=:;DB@7=/:4>DGE=?EDF@76=73@402+9))79:<402>J208829<>H@BC7F?@DOL>;C88=;1256<=@99<DGIFB8>>?EEKFTIEBDHD9@>DAHAA9;@=88?><6>C@>B@<?9::8:>GEKA<8778404-'()00.00.(/&.6661/+/&$&&% +@SRR11410539.2484305 2484305/1 +GTTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACAGGAATCGACAGCACCTACAGTATTCTTTGCTATAGTAGTCGGCATAGATGCTTTAATTCTAGAATTTGTACTTCTAGTAAAAGTACACAATTGTAGCAATAAAATAAAGAAATAAGGCATATAATTAGTACAAACACAGTTTAAACACCGTGTAACTATGTTAGTAGTTGTACTAACAACTTTGTTAAGAAAAGGAAACAGCATAATTAGCTATAGTATCCCAAGGGACACTATTAGCAGCTAAACCATGGTAGCAAGGGTTTTCAAACCTAATACTCTAGATAATTCATTAGGTTTCTTAATAGTAGGGCTAGAATTGTCTACATAAGCAGCCATTAGATCTGTGTAGCCCAACCTCTTCTCTGTAATTTTTAAACTATTATTTGCTGGTTTAAGTATAATGTCTCCTACAACTTCGGTAGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAACTT ++ +*++(*)57::=D8/*6+/<63443617812/?HEFJAAB?F;=94/7:?A=*$7;<;..<=87))<>=06756DAB>76@E?CG,=BGDGA;B6>B;859:53/0@8ADCA?1<,1>BEL??>9;=>@@99FGH@;EA>H;21(+196?>651)+),.=;2+11B9<=<=?BBFB>?828-?>>=@?;8(&<78;?NF@76/6=9:1249743/-/'**4,08<;8-.+*%%$%'589;22(35/*&&)'&*0-19?EFII@CCB=ACCEE::>845+;?54951)$$)(115=0CE;<@?:$*281512:%;CCO6?110=&:DHG?=<@:><BCADAC=%%54==IEC?DC>B?87)6&)%3,8&.9@ED=>===<9-.56:205%%+)3..71054)%%&''...47AD8.%,6<@CDDEQOE@B0<1EFB8C>QEJI>@LK=23(,.1:>?B<=C8?B;:=:))D8>=;129A63?BDD:48:...699DCE=BED;>?>B=ACDD???>;<=<=BBADD><98$$& +@SRR11410539.378851 378851/1 +CGTGTACTTCGTTCAGTTACGTATTGCTAAGGGTTAGAACTGACTACAAGCGGAATCGACATGCACCTGTTGAACCTTTCTACAAGCCGCATTAAATCTTCCGAAAGTTCATCACCAATTATGGGGATATTCAATAGTCAGTCAACGCGCTTAACAAACGCTGGCTGGACAGCTAGACACCTAGTCATGATTGCATCACAACTAGCTACATGTGCATTACCTGTGGACTTGACAATACAGATCATGGTTGCTTTGTAGTTATAAAGCCATTGTTTGAACATCAATCATAAACGGATTATAGACGTAATCAATCCAATAGAATGATGCCCGCAGGCATAAGTTAATCTGAAGCAGTGGAAAGCATCAATGGCGTCTATCACACCAGACAACAAGGTGCGCTCCAGGTCCTATTTTCACAAAATACTTCACCAGATGTCAACTCAAAGCTTATGTACCAAGGTGCTGTCAGTTCAGTTTGTATGGTCGTCTGTTCCAGCTATGTTCGCTACGCTAACATA ++ +&%($$$"#$&)()($/.-%1./001('-'('+7>6---,),75?>9;79%;*,,0*2-,+&#$(+00-+)&%%&(,(..2)&$25,33%)$##'+*)-$(#&#%%%,9<:85.',,')'*((&*794($$%'%%'&.&6-9<?$$(%$$##$&&&#%%3$%,%&$,8;<849>=@C@?7;:9=>;:6@F??G=@>=@A==<<<D;=A>4<>@CCD776)((*+&9;=:NJF@@:<=0//-(//43+/EE3../2,'%(*+'-01,$,%+$*(15<??A4=<A<<@@0479>?:><368565.-/--,.814,,?=>9264?6-/3-1/#$%%&1:01021,2-,)*%&-2,-,):*+**'&,&$$%%($&)-44+)-6.2&#&01:9((0&&612-(/8=%41-79;=>5GGL</--8:<B::112*%%%*.1)*096;>>=990$$$%%$#$####$)$/%%*%$&%$%&&%%&''$$'.%)+*(&&&%&'#$$#"&#$##$%#"%#%%$---.'($ +@SRR11410539.1346832 1346832/1 +CGGTGTACTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTTCAGGTGATGGCACAACAAAGTCTATTTCTGAACATGACTACCAGATTGGTTATACTGAAAATAGGAATCTGGGTAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGGATTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACATGTACTCATTCGTTTCGGAAAGACAAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCATAGGTGCTGTCGATTCCGTTTGTAAGTCGTCTGTTTTGAAAACATAGCAATACGTAACT ++ +5$(%,--;==9;M.5/<@@=B?D??D@AC66-BCCDH6?:9=A9:7676FG@>;=FD?==?;97B@@BA/0*9=@8=B?@;99**4231+&8,CGE06,33=><AEEAGH>AJEA:1))BDB<;>>@@B:3+*(&(*03(-4CB?:.51,9;DA@=;4++,7<=<6CA<40125868/0.4&4/423@=7@4@DDC>8=?BDB2>999;776?@@>A=998956@><B;;??=@<;<;???B<HE@5<@:BAEGA:@DHBGDCCB?/<(../.==010<@;;<11A:6/47B5:=C<>?ECHL;AFJBE''?33/77-6>7:=AE::/'4877GFIJF49()(-75878=<;BA>?>B?A@DCCBFGGLA?;GE>@?FI88/040)5894ACIHA@>AFA876(&>>CC?=D9217@<HD?A-/)-&+46$&91+2A@F>AA;886>;;31;<=51<?@?B?EB@?GF=:ACC9''%&.1%$3%7:@8888<8AA<+(%(22>16=?@>?@1)))($%%1233AB;=EBB91#( +@SRR11410539.1236160 1236160/1 +CATTATGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACGGAGCGACTACAAACGGAATCGACAGCACCTACTACCGAAGTTGTAGGAGACGATAAACCAGCAAATAATAGTTTAAAAATTACAGAGAGAGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGGATACTATAGCTAATTATGCTAAGCCTTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTTGTAGGTGCTGTCGATTCCGTTTGTGATCGTCTGTTTAACCTTAGCAATACGTAACT ++ +(%$&(%%-./36=:=35=@.BDA?>B;>?AA+@DD88-6$)$$58=<=408908')+><@<?31803>?>7>C<A<60)5-293855--3*$1-&),%2-*-ACEA:;0%%<>FGPE@A;<07873**.$+&,+'''61,=++:;?AFHABE@F@89CC>@>9:<:7?0:BA<;99KJHCIJ??>?<0:<>::++AEBBCADAB?;6+@B9=C@EGH?55?<145-,4#&==;@/*69<EFB;@@B=?AC@C@@<@4B>89?89:*.8<:,(05329..0*.*,=8<:@++)252@C@??KF321><:>9?69>B>97?67AEC;D:7/+;---2-**0.968=AD5HF?DC?>@,2/,+&'$'.,&$$4786.=@6,--*&',/AA>IDIHB8;<8<<087:<@CKB8:8<0-6&1)8>CE><6.5&8801?@+*<<:BA=$$6)&658130)*3+2BB-':<32,/4&0635??>BD=A@>?2369A;3+,#$8;:>@:<CD?2/***,G<A<==<C;920+* +@SRR11410539.234314 234314/1 +GAGCCTCATGCTTCATTCAGGTTACATTATTATCTAAGGTTAAACAGACGACTACAAAACAGATCGACAACTGCTTAACTCACATACAGACATTACAGACTGTGTTTTTAAGTGTAAAACCCACAGGGTCATTAGCACAAGTTGTAGGTATTTGTACATACTTACCTTTAAGTCACAAAATCCTTTAGGTTGGATGATCTATGTGGCAACGGCAGTACGGACAACACGATGCACCTAGGGATTCTTGATCCATATTGGCTTCCAGTGTAACTGTTGCCTGACCAGTACAGGTGTGTGTGTACACAACATCTTAACACAATTAGTGATTAGTTTGTCCCCACTAGCTGGAAGATAATCTTTGTAAGCTTTAGCAGCATCTACAACAAAGCACAGAAGAGATAATACAGTTGAATTGGCAGGCACTTCTGTTGCATTACCAGCTTGTAGACGTACTGGCAGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTCAACCTTAGCCAATGCGTAACT ++ +$###$%%$%%&&'%$$--+,)'***)'(#++$($'&&+*&'%&%%&(++'&.1--89>=8;;4-6675('(*)'''01/05,2.'&+'(%'*+/%++8:*@065430/+')-;2.:<<0956-4145+19..10./222+1'064--20.;;D73A@;56:;<;7;7875735B<:9925''.''%"&)&*.2<A>:5>22*)500.'':230)1/29$+975120-/,.*)&*+.*0+5&9<A>C@<9:?;88:>7::>@,209=?@;9381)+;@@DF>85901--'054$+'1&*'--731,,6>>@AB<:8C?>>>9118=88/)301B7;<?G==<35/2.')'+%5..28:??8&&%%/-/0),*,71898B.%5&&***11?87727,%&4:3**++8/>>?679=?5=.(.3=>=AAC//ADBICEC>=2).((-974<4==;5:52'%$,CBBD?;EGDCA137:96)'785A;7D..-.&()$($%%##%-.*)1$(,-&& +@SRR11410539.2477472 2477472/1 +TCTAAGTACGCTAGTTGATTACAATATTATAGGATTAAACAGACGTTTCGACAGATCGACAACTTCACCTCATCTTTAAGATGTTGATGCACTCTGATAAGACCTCCTCACGGAGTCTCAAAACCACGTACAGTACGTCGCGAACCTGTAAAACAGGCAAACTGAGTGGACGTGTGTTTTTCTCGGTGAGAGCTCCAGGAATAGGGCTCTCCATCTTACCTTTCGGTCACACCGGACAAAACCTAGATGTGCTGATGATCGGCTGCAACACGGACGAAACCGTAAGCGGCCTGCGGAAGATAGACGAGTTACTCGTGTCCTGTCAACGACGGTAATTAGTTATTAATTATACTGCGTGAGTCATAAACATGCAGCCAGGTGACAACCACCTGAACCCTGGGATCGTTTAGAGAACAGGTCTACAAGAGATCGAAAGTTGGTTGGTAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTGAACCTTAGTAATGCAATGGCTT ++ 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+CAGTGTACTTCGTTCAGTTACGTATTGCCTAAGGTTAAACAGACGACTACAAACAGAATCGACAGCACCTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTATTAAAGAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCTAAAGCTATTAAGTGTGTACCTCAAAGCTGATGTAAAGGAATGGAAGTTCTATGATGCACAGCCTTGTAGTAAAGCTTATAAAATAGAAGGTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTGTAGGTGCTGTCTGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATCGTAAC ++ +*%#&(*+&&+)29+=7=DEF98<<8;51%$$%.@NFEE>6,/.5;:>A8399*'&)-.=C?E@F@II@AHJ;DE895=;CEEDD>CF>ADAA>8;8;DD@44560/%&%(%%7>?B@@C74242&1592511B<@DPLA=336B*0FE5<69@@D:@7?@0&65:;26533;CB;GFEE<<>3$*)(')*/1?A68@BBFEDG=0/.<BFBCD,.3>?<:7ACJE>;0,/01+&-3.,:586@343,=:=750-%&%)(/=:56226;94*&&%'3357:?:@ACD4,%)(,.,'555=>?A<C?115*'1>B@><0/8??A6.>@;><>@ABA1(27:=B:66:)-.41:;6:>B?<>BEDIDHDI>;B=;;B5?=A?>787>?B>HEH::=GCDHBC9=(1>BE=A?A47/0$146=>ED?@B<;@H>>E?<AB?@??@?/($..1GGKABELBA<>>/3400.)8<A<;>98C4480),'24?>&('+.D;=<;76210$$)+'+,(+(.0--+,#$%$&'% +@SRR11410539.20470 20470/1 +TGATGTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAGCAGACGACTACAAACCAGATCGACAGCACCTCATTTCATCTGTGAGCAAAGGTGGCAAAAACATTAAGGCCGTTCAAACTTTGTACGCACAAATGAGGTCTCTAGCAACAATATCACCAAGGCAATCACCATATTGTTTGATGAAGCCAGCATCTGCAAGTGTCACTTTGTTGAAAAGTAGATCTTCAATAAATGACCTCTTCGCTGATTTTGATGAATCTGGTAATATTTGTGAAAATTAAAACCATAAATCTTTAATTGGTGGTGTTTTGTAAATTTGTTTGACTTGCAAGCTTCTTGGGTGTTTTGTCTTGTTCAACAACTATTCCAGTTAAAGCACGGTTTAATTGTGTACAAAAACTGCCATATTGCAACAAGATTGCTGCATTCAGTTGAATCACCACAGGTGCTGTCGATTCCGATTGTAGTCGTCTGTTTAACTATATACATAATTT ++ +%34&&8%89;<<K--%8=BAA@DAAB>>A>>+8.2)''.,-25?@>?5-57>)5.0=8??E>>@CCBAHB9@EJB?>F?<=;8@996&+09013.35/+.*%'/00,,-+--&')%;==7*+$&+..1/1<3811?58-8*/'1%%/>A>4/2'%.$%('2--.0202265CD=DDCB@852),.),*;A?EIAD:=:52)*%&0<GADBBBC:56:?;>>AJ9AEE?>@C=::B<;=8-%#"(*$$)/'%4+,%-7A9.0<:733@DH7===?:235;<@279*)&,;>@SPI@BCC;?>48ABCCNL?A882?DK@@CB<7&&&%%01)<A><88%&&+$$%+2;?B?>;@A9015&&,>@=A(.23JGDE99A>CC?HG;22.4>%87;<EEFI<<>@BB6..481<=9B12-55=AAFA):A5;2?<A?AB??.@<93+129,9:2;>BAEC++)$%*3,22:=778,,01-011++(%'%'&%$$##$ +@SRR11410539.860199 860199/1 +CATTGTACTTCGTTCGGTTACGTATTGCTAGGTTAAACAGACGACTACAAACGGAGATCGACAGCACCTTTAGCTTGGTTGTACGCTGCTGTTATAAGTAAAGGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCCTCTAACACAAGACCATGTTGACATACATTTGCTAGAGGACCTCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATGTGTGTGCTTCATTAAAAGAATACTGGAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTTGATAGAAGATGAATTTACACCTTTTGATGTTTGTTAAGACAATGCTCAGGTGTTATTTTCCAAAGTGCAGTGAAAAAGAACAATCAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAAAGTACTCAATGGTCTTTGTTCAGGTGCTGTCGATTCCGTTTGTAGTCGTCTGTTTAACCTTAGCAATACGTAAC ++ +##$%%''78:<8G0?%,064.(0*+.*.,1&?KI@B)9**7<>>?:0;5678.(.$792:(.,*//+.+,BB=<<<>BEKCHEAFBF>=I=FD=955$('*''-0/2.<=:;KLBD,C<;79=<A=8=?;87,-:>;BC>?=?@;=H?88>A@F@F@B?;8:83-1<B:=:9@;?A?@?<5;<?=?=?;ACCA=>=?9>5/*+&#$(%')($$%)&$$%&*-/'<=ECF;:)#(@@CCAE;<F>?D9896CBN@:66-%%,.0@=:=>6:98JL@(%-*2/++'&6;AA?@?:0>6<B?A3422;==;61///384+-0)&3343%%681:7:;66178>C?>@<@?HBACEC?GBD:9;*-;B=CF@BAE9;458769;=?DC-1BB5/=.+)+7--=7.'/8AADD>.0(3688$97<?;=;A5:AE9>3+55?4<==:966<.?IHBG?EGH@9BDEQ:07,,4%%%%76AD=AB>:==A>>@:C7/5-=BAB=@<DDDCA?A>FDC<?99:94<@9>AB:&'/2017037754/++''% +@SRR11410539.432634 432634/1 +CATTGCTTCGTTCAGTTACGTATTGCTAAGGTTAAACAGACGACTACAAACGGAATCGACAGCACCTAGCAGCATCTACAGCAAAAGCACAGAAAGATAATACAGTTGAATTGGCAGGCACTTCTGTTGCATTACCAGCTTGTAGACGTACTGTGGCAGCCTAAACTACCAAGTACCATACCTCTATTTAATTTTGTTCCAATCCTTTAATAAAGTATAAATACTTCACTTTAGGACCTTTAGGTGTGTCTTGTAACAAACCTACAAGGTGGTTCCAGTTCAACATAGATAGTACCAGTTCCATCACTCTTAGGGAATCTAGCCCATTTCAAATCCTGTAAATCCGGATAACAGTGCAAGTACAAACCTACCTCCCTTTGTTGTGTTGTAGTAAGCTAACGCATTGTCATCAGTGCAAGCAGTTTGTGTAGTACCGGCAGCGCAAGACATCTGTCGTAAGGTGCTGTCGATTCCGTTGACCCCAGCAGTCGTCTCTTTAACAACAACAACTACGTAAC ++ 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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/SRR11410539_seqtk_sample_250_1.fastq.consensus.fasta Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,500 @@ +>SRR11410539_seqtk_sample_250_1.fastq/ARTIC/medaka MN908947.3 +ANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN +NNNNCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGANNNNNNNNNNNNNNN 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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/all_fasta.loc Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,7 @@ +# Tab separated with three columns: +# - value (Galaxy records this in the Galaxy DB) +# - dbkey (Database key) +# - name (Galaxy shows this in the UI) +# - path (the reference file) +# +test_entry test "Test Reference" ${__HERE__}/nCoV-2019.reference.fasta
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/nCoV-2019.V1.bed Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,196 @@ +MN908947.3 30 54 nCoV-2019_1_LEFT 60 + +MN908947.3 385 410 nCoV-2019_1_RIGHT 60 - +MN908947.3 320 342 nCoV-2019_2_LEFT 60 + +MN908947.3 704 726 nCoV-2019_2_RIGHT 60 - +MN908947.3 642 664 nCoV-2019_3_LEFT 60 + +MN908947.3 1004 1028 nCoV-2019_3_RIGHT 60 - +MN908947.3 943 965 nCoV-2019_4_LEFT 60 + +MN908947.3 1312 1337 nCoV-2019_4_RIGHT 60 - +MN908947.3 1242 1264 nCoV-2019_5_LEFT 60 + +MN908947.3 1623 1651 nCoV-2019_5_RIGHT 60 - +MN908947.3 1573 1595 nCoV-2019_6_LEFT 60 + +MN908947.3 1942 1964 nCoV-2019_6_RIGHT 60 - +MN908947.3 1875 1897 nCoV-2019_7_LEFT 60 + +MN908947.3 2247 2269 nCoV-2019_7_RIGHT 60 - +MN908947.3 2181 2205 nCoV-2019_8_LEFT 60 + +MN908947.3 2568 2592 nCoV-2019_8_RIGHT 60 - +MN908947.3 2505 2529 nCoV-2019_9_LEFT 60 + +MN908947.3 2882 2904 nCoV-2019_9_RIGHT 60 - +MN908947.3 2826 2850 nCoV-2019_10_LEFT 60 + +MN908947.3 3183 3210 nCoV-2019_10_RIGHT 60 - 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+MN908947.3 26520 26542 nCoV-2019_88_LEFT 60 + +MN908947.3 26890 26913 nCoV-2019_88_RIGHT 60 - +MN908947.3 26835 26857 nCoV-2019_89_LEFT 60 + +MN908947.3 27202 27227 nCoV-2019_89_RIGHT 60 - +MN908947.3 27141 27164 nCoV-2019_90_LEFT 60 + +MN908947.3 27511 27533 nCoV-2019_90_RIGHT 60 - +MN908947.3 27446 27471 nCoV-2019_91_LEFT 60 + +MN908947.3 27825 27854 nCoV-2019_91_RIGHT 60 - +MN908947.3 27784 27808 nCoV-2019_92_LEFT 60 + +MN908947.3 28145 28172 nCoV-2019_92_RIGHT 60 - +MN908947.3 28081 28104 nCoV-2019_93_LEFT 60 + +MN908947.3 28442 28464 nCoV-2019_93_RIGHT 60 - +MN908947.3 28394 28416 nCoV-2019_94_LEFT 60 + +MN908947.3 28756 28779 nCoV-2019_94_RIGHT 60 - +MN908947.3 28677 28699 nCoV-2019_95_LEFT 60 + +MN908947.3 29041 29063 nCoV-2019_95_RIGHT 60 - +MN908947.3 28985 29007 nCoV-2019_96_LEFT 60 + +MN908947.3 29356 29378 nCoV-2019_96_RIGHT 60 - +MN908947.3 29288 29316 nCoV-2019_97_LEFT 60 + +MN908947.3 29665 29693 nCoV-2019_97_RIGHT 60 - +MN908947.3 29486 29510 nCoV-2019_98_LEFT 60 + +MN908947.3 29836 29866 nCoV-2019_98_RIGHT 60 -
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/nCoV-2019.reference.fasta Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,500 @@ +>MN908947.3 +ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCT +GTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACT +CACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATC +TTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTT +CGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAAC +ACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGG +AGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGG +CTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAA +ACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACT +CGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGG +CGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGG +TGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGA +TCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGA +ACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGG +CCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTC +ATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCG +TGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCA +GACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAA +TTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAA +GCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATG +CAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCA +GACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGA +AGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGC +ATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGG +CTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTC +TTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGG +TTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGA +AATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGA +GATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAA +AGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTAC +AAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCC +TCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCT +TGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGG +AATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTAC +TAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTG +GCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGA +AGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTAT +CTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAA +GGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTC +TATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCA +CTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCC +TCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTT +AACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGA +AGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGA +AATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATAC +CTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGA +AGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGT +ACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGC +CTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACC +ACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGG +TGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTACCCTCCAGATGAGGATGAAGA +AGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGA +AGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGA +AGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGA +CGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATT +AGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTT +AAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGT +AAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGC +AGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGC +TACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAA +ACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAA +GAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGG +TATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAA +TGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGA +AATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAA +GCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAAT +CAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAA +CTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAG +TGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCA +AGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAAT +GCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCA +GGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGC +CTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTC +TTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTG +TGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACA +AGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGC +GTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTA +TGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCC +AGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTC +TTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAA +AGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGA +TAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCAC +CTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTAC +AACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACA +ACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTC +ACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTT +TGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCA +CACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAA +CAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCC +ACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGC +ACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAAT +GAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTG +TAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGG +CACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACA +AGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGC +TCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCA +GTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTT +ACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAG +TTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAAT +TGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAAT +TGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATG +TGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTC +AAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTA +TAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTG +GCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTG +TCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGA +CGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGT +GGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGT +AGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCA +CACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGA +ATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAG +TGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTAC +AACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTT +CTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGC +ATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGA +GGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTG +GTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGT +TTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAA +CTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCT +TAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTC +ATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATAT +TCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAG +CTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGT +ACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTA +TGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTG +TTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAG +GTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTG +TGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGA +CTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGA +TAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGAC +TTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACAC +TAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATC +ATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACT +AGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGA +TGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACT +AGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTAC +TTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGT +TGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAA +CTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTAT +TGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGAT +ATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGC +TGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAA +TGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCA +GTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACC +TGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTAT +TGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGC +TGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCC +ATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCAC +GATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGT +TGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGC +TTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATA +TTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACAC +ACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTC +TGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATC +AGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAG +ATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTAC +ACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTAT +TGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGG +TGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACT +CTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTT +GACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTT +CACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCA +TTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTT +TAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAA +GTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAA +TAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTG +TCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACC +ACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCC +ATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGG +TCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACAT +GCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACA +GGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCT +TAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGG +ACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGC +TATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGG +TTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAAC +TGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCA +AACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTA +CGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGA +CTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACAT +ACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAA +AGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGA +TGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGT +GAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTT +AGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTT +ACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAA +GCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATAT +GGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATAC +TAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACT +AATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTAT +GAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTC +CATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCAT +GTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAAC +TGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTG +TTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGA +TTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAA +GAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTG +TATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTT +ACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGT +CCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGT +TTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGA +AGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCC +ATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGA +TTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGA +CCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAAT +GTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAAT +GCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGC +AAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGT +TGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGC +ATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAG +TGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAG +GGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGAT +GTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTA +CAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAA +ATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACC +TTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAA +AGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCT +ACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTT +TGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCAC +TAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACC +GGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTG +CCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAAT +ACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGT +CTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCA +GTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACA +CCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGAT +AAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGAC +GAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTAC +CAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGAC +TTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACT +AAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGAC +ACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAG +GACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAA +CGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGT +ATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGT +GATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTG +TTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGAC +TTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTA +AAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAAC +TGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTG +TTCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTT +GTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAAC +TTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATG +CACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCA +CTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTAT +GACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTC +TTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTA +CCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTT +GATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAA +TCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGT +TATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACT +CAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTC +TCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCC +GCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAAC +ATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCT +AAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGC +AAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCT +CAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACC +TCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTC +ACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTC +CGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGAC +TTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGAC +GATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAG +AACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGG +ACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTT +AAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCC +GGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTG +TCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTC +TTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTA +GACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTT +TATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGC +AATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAA +TGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTAT +GTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATG +AGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAA +GTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCA +ATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAA +AGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCT +TATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAA +GTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACT +AAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCT +GTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACA +TCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGA +ATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAAT +TATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAG +AGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCT +TGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGAT +AAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTG +AATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCA +GATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAAT +GCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCA +CGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTT +ATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATT +GTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCA +GCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATT +AACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAA +GCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTA +CCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAA +ACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCA +AAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACA +AGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTC +TTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTC +AGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAG +GACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAAT +GGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATT +GGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTA +CAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACA +CCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAA +CACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTA +CAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCA +CATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGT +TGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGG +CATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGG +GGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCA +CATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTT +AAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCG +GCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCA +GTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAA +TGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTC +TATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGC +AATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCT +AACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCAC +ACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTAC +TCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCA +CTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCAT +GCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGC +TTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAG +AGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGT +GAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTA +GAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAG +CGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCT +GCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGT +GTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACT +GTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGT +GTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCT +AGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAG +AAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTA +CAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAA +TTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTT +AGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAA +TCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATA +ACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGAT +GATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTG +ACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACA +TTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTT +TACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCA +ACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTA +AACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCT +GATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTG +CTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGAT +TGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCT +AAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGT +GGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACAT +TCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTT +ACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAA +CCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACA +AATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTA +AGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTT +CTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTT +CTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAG +TCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCAC +ACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGA +CTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGAC +CAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGC +TTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAA +GACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATT +TCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGAT +GGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCA +GCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGT +GTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGT +GCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTAT +TAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGA +TTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAG +GACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACT +TGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTA +TCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTAC +AAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTG +GAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATC +ATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTAC +TAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGG +GCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGT +TATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTA +TAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTA +TCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACA +ATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACT +TTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTT +GGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTAC +TGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTAC +TGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGG +TGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCA +GGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTG +GCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGC +TGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAG +TTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCAT +TGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGC +CATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAA +GACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTT +GTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGA +ACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACC +AATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAG +CAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTT +CATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACA +AAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATA +CACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGC +ATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACA +GAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAA +AATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAA +CCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAAT +TTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAAT +TGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAAT +TAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGT +ACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCC +TCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAA +GAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGG +TGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACA +AATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGT +CAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGA +TAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAA +TGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTT +AAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCC +ATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTAT +GCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTG +CTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACAC +ATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAG +CAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCG +ATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTT +CAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGT +GTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTC +GTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAG +AGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAA +AACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTAT +TGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACA +AGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGA +GTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCA +ACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATT +GTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTT +AATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAA +GCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTA +ATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCC +ATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTA +AAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGAT +CTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAG +CCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAAT +GGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATG +CCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAG +TAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAA +TTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTT +TCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTC +TCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAA +TCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTG +ACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACA +AATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACA +GGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGC +TTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAG +ATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATA +AACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGAT +GAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTG +ATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTA +CTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTA +GCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGAC +GGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGA +CAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTT +ATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACT +TCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTT +GGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAAT +TTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTAC +AGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATT +CTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGG +ATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCT +GTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTT +CGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAA +CGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTAC +GTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCG +ATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCT +CACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACAC +CAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGG +TGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGG +GCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGA +GGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGC +AATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAG +CAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAA +TTCAACTCCAGGCAGCAGTAGGGGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGA +TGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGG +TAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAA +GAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAG +ACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAAC +TGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGG +AATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGC +CATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCA +TATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGC +TGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCC +TGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTC +AACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGC +TTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGC +ACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTA +GGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGT +ACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAAT +TTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAA +AAAAAAAAAAAAAAAAAAAAAAA
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/nCoV-2019.scheme.V3.bed Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,218 @@ +MN908947.3 30 54 nCoV-2019_1_LEFT nCoV-2019_1 +MN908947.3 385 410 nCoV-2019_1_RIGHT nCoV-2019_1 +MN908947.3 320 342 nCoV-2019_2_LEFT nCoV-2019_2 +MN908947.3 704 726 nCoV-2019_2_RIGHT nCoV-2019_2 +MN908947.3 642 664 nCoV-2019_3_LEFT nCoV-2019_1 +MN908947.3 1004 1028 nCoV-2019_3_RIGHT nCoV-2019_1 +MN908947.3 943 965 nCoV-2019_4_LEFT nCoV-2019_2 +MN908947.3 1312 1337 nCoV-2019_4_RIGHT nCoV-2019_2 +MN908947.3 1242 1264 nCoV-2019_5_LEFT nCoV-2019_1 +MN908947.3 1623 1651 nCoV-2019_5_RIGHT nCoV-2019_1 +MN908947.3 1573 1595 nCoV-2019_6_LEFT nCoV-2019_2 +MN908947.3 1942 1964 nCoV-2019_6_RIGHT nCoV-2019_2 +MN908947.3 1875 1897 nCoV-2019_7_LEFT nCoV-2019_1 +MN908947.3 1868 1890 nCoV-2019_7_LEFT_alt0 nCoV-2019_1 +MN908947.3 2247 2269 nCoV-2019_7_RIGHT nCoV-2019_1 +MN908947.3 2242 2264 nCoV-2019_7_RIGHT_alt5 nCoV-2019_1 +MN908947.3 2181 2205 nCoV-2019_8_LEFT nCoV-2019_2 +MN908947.3 2568 2592 nCoV-2019_8_RIGHT nCoV-2019_2 +MN908947.3 2505 2529 nCoV-2019_9_LEFT nCoV-2019_1 +MN908947.3 2504 2528 nCoV-2019_9_LEFT_alt4 nCoV-2019_1 +MN908947.3 2882 2904 nCoV-2019_9_RIGHT nCoV-2019_1 +MN908947.3 2880 2902 nCoV-2019_9_RIGHT_alt2 nCoV-2019_1 +MN908947.3 2826 2850 nCoV-2019_10_LEFT nCoV-2019_2 +MN908947.3 3183 3210 nCoV-2019_10_RIGHT nCoV-2019_2 +MN908947.3 3144 3166 nCoV-2019_11_LEFT nCoV-2019_1 +MN908947.3 3507 3531 nCoV-2019_11_RIGHT nCoV-2019_1 +MN908947.3 3460 3482 nCoV-2019_12_LEFT nCoV-2019_2 +MN908947.3 3826 3853 nCoV-2019_12_RIGHT nCoV-2019_2 +MN908947.3 3771 3795 nCoV-2019_13_LEFT nCoV-2019_1 +MN908947.3 4142 4164 nCoV-2019_13_RIGHT nCoV-2019_1 +MN908947.3 4054 4077 nCoV-2019_14_LEFT nCoV-2019_2 +MN908947.3 4044 4068 nCoV-2019_14_LEFT_alt4 nCoV-2019_2 +MN908947.3 4428 4450 nCoV-2019_14_RIGHT nCoV-2019_2 +MN908947.3 4402 4424 nCoV-2019_14_RIGHT_alt2 nCoV-2019_2 +MN908947.3 4294 4321 nCoV-2019_15_LEFT nCoV-2019_1 +MN908947.3 4296 4322 nCoV-2019_15_LEFT_alt1 nCoV-2019_1 +MN908947.3 4674 4696 nCoV-2019_15_RIGHT nCoV-2019_1 +MN908947.3 4666 4689 nCoV-2019_15_RIGHT_alt3 nCoV-2019_1 +MN908947.3 4636 4658 nCoV-2019_16_LEFT nCoV-2019_2 +MN908947.3 4995 5017 nCoV-2019_16_RIGHT nCoV-2019_2 +MN908947.3 4939 4966 nCoV-2019_17_LEFT nCoV-2019_1 +MN908947.3 5296 5321 nCoV-2019_17_RIGHT nCoV-2019_1 +MN908947.3 5230 5259 nCoV-2019_18_LEFT nCoV-2019_2 +MN908947.3 5257 5287 nCoV-2019_18_LEFT_alt2 nCoV-2019_2 +MN908947.3 5620 5644 nCoV-2019_18_RIGHT nCoV-2019_2 +MN908947.3 5620 5643 nCoV-2019_18_RIGHT_alt1 nCoV-2019_2 +MN908947.3 5563 5586 nCoV-2019_19_LEFT nCoV-2019_1 +MN908947.3 5932 5957 nCoV-2019_19_RIGHT nCoV-2019_1 +MN908947.3 5867 5894 nCoV-2019_20_LEFT nCoV-2019_2 +MN908947.3 6247 6272 nCoV-2019_20_RIGHT nCoV-2019_2 +MN908947.3 6167 6196 nCoV-2019_21_LEFT nCoV-2019_1 +MN908947.3 6168 6197 nCoV-2019_21_LEFT_alt2 nCoV-2019_1 +MN908947.3 6528 6550 nCoV-2019_21_RIGHT nCoV-2019_1 +MN908947.3 6526 6548 nCoV-2019_21_RIGHT_alt0 nCoV-2019_1 +MN908947.3 6466 6495 nCoV-2019_22_LEFT nCoV-2019_2 +MN908947.3 6846 6873 nCoV-2019_22_RIGHT nCoV-2019_2 +MN908947.3 6718 6745 nCoV-2019_23_LEFT nCoV-2019_1 +MN908947.3 7092 7117 nCoV-2019_23_RIGHT nCoV-2019_1 +MN908947.3 7035 7058 nCoV-2019_24_LEFT nCoV-2019_2 +MN908947.3 7389 7415 nCoV-2019_24_RIGHT nCoV-2019_2 +MN908947.3 7305 7332 nCoV-2019_25_LEFT nCoV-2019_1 +MN908947.3 7671 7694 nCoV-2019_25_RIGHT nCoV-2019_1 +MN908947.3 7626 7651 nCoV-2019_26_LEFT nCoV-2019_2 +MN908947.3 7997 8019 nCoV-2019_26_RIGHT nCoV-2019_2 +MN908947.3 7943 7968 nCoV-2019_27_LEFT nCoV-2019_1 +MN908947.3 8319 8341 nCoV-2019_27_RIGHT nCoV-2019_1 +MN908947.3 8249 8275 nCoV-2019_28_LEFT nCoV-2019_2 +MN908947.3 8635 8661 nCoV-2019_28_RIGHT nCoV-2019_2 +MN908947.3 8595 8619 nCoV-2019_29_LEFT nCoV-2019_1 +MN908947.3 8954 8983 nCoV-2019_29_RIGHT nCoV-2019_1 +MN908947.3 8888 8913 nCoV-2019_30_LEFT nCoV-2019_2 +MN908947.3 9245 9271 nCoV-2019_30_RIGHT nCoV-2019_2 +MN908947.3 9204 9226 nCoV-2019_31_LEFT nCoV-2019_1 +MN908947.3 9557 9585 nCoV-2019_31_RIGHT nCoV-2019_1 +MN908947.3 9477 9502 nCoV-2019_32_LEFT nCoV-2019_2 +MN908947.3 9834 9858 nCoV-2019_32_RIGHT nCoV-2019_2 +MN908947.3 9784 9806 nCoV-2019_33_LEFT nCoV-2019_1 +MN908947.3 10146 10171 nCoV-2019_33_RIGHT nCoV-2019_1 +MN908947.3 10076 10099 nCoV-2019_34_LEFT nCoV-2019_2 +MN908947.3 10437 10459 nCoV-2019_34_RIGHT nCoV-2019_2 +MN908947.3 10362 10384 nCoV-2019_35_LEFT nCoV-2019_1 +MN908947.3 10737 10763 nCoV-2019_35_RIGHT nCoV-2019_1 +MN908947.3 10666 10688 nCoV-2019_36_LEFT nCoV-2019_2 +MN908947.3 11048 11074 nCoV-2019_36_RIGHT nCoV-2019_2 +MN908947.3 10999 11022 nCoV-2019_37_LEFT nCoV-2019_1 +MN908947.3 11372 11394 nCoV-2019_37_RIGHT nCoV-2019_1 +MN908947.3 11306 11331 nCoV-2019_38_LEFT nCoV-2019_2 +MN908947.3 11668 11693 nCoV-2019_38_RIGHT nCoV-2019_2 +MN908947.3 11555 11584 nCoV-2019_39_LEFT nCoV-2019_1 +MN908947.3 11927 11949 nCoV-2019_39_RIGHT nCoV-2019_1 +MN908947.3 11863 11889 nCoV-2019_40_LEFT nCoV-2019_2 +MN908947.3 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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/primer_scheme_bedfiles.loc Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,6 @@ +# Tab separated with three columns: +# - value (Galaxy records this in the Galaxy DB) +# - name (Galaxy shows this in the UI) +# - path (the primer scheme bedfile) +# +test_entry "Test Database" ${__HERE__}/nCoV-2019.scheme.V3.bed
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool-data/all_fasta.loc.sample Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,18 @@ +#This file lists the locations and dbkeys of all the fasta files +#under the "genome" directory (a directory that contains a directory +#for each build). The script extract_fasta.py will generate the file +#all_fasta.loc. This file has the format (white space characters are +#TAB characters): +# +#<unique_build_id> <dbkey> <display_name> <file_path> +# +#So, all_fasta.loc could look something like this: +# +#apiMel3 apiMel3 Honeybee (Apis mellifera): apiMel3 /path/to/genome/apiMel3/apiMel3.fa +#hg19canon hg19 Human (Homo sapiens): hg19 Canonical /path/to/genome/hg19/hg19canon.fa +#hg19full hg19 Human (Homo sapiens): hg19 Full /path/to/genome/hg19/hg19full.fa +# +#Your all_fasta.loc file should contain an entry for each individual +#fasta file. So there will be multiple fasta files for each build, +#such as with hg19 above. +#
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool-data/primer_scheme_bedfiles.loc.sample Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,8 @@ +# this is a tab separated file describing the location of primer schemes used for amplicon +# sequencing (e.g. using the ARTIC SARS-CoV-2 protocol) +# +# the columns are: +# value description path +# +# for example +# SARS-CoV-2-ARTICv1 SARS-CoV-2 ARTIC v1 primers /data/galaxy/tool_data/artic_primers/SARS-CoV-2-ARTICv1.bed
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool_data_table_conf.xml.sample Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,13 @@ +<?xml version="1.0"?> +<tables> + <!-- Locations of primer scheme bedfiles in the required format --> + <table name="primer_scheme_bedfiles" comment_char="#" allow_duplicate_entries="False"> + <columns>value, description, path</columns> + <file path="tool-data/primer_scheme_bedfiles.loc" /> + </table> + <!-- Locations of reference fasta files --> + <table name="all_fasta" comment_char="#"> + <columns>value, dbkey, name, path</columns> + <file path="tool-data/all_fasta.loc" /> + </table> +</tables>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool_data_table_conf.xml.test Thu Apr 30 04:05:09 2020 -0400 @@ -0,0 +1,12 @@ +<?xml version="1.0"?> +<tables> + <!-- Locations of primer scheme bedfiles --> + <table name="primer_scheme_bedfiles" comment_char="#"> + <columns>value, name, path</columns> + <file path="${__HERE__}/test-data/primer_scheme_bedfiles.loc" /> + </table> + <table name="all_fasta" comment_char="#"> + <columns>value, dbkey, name, path</columns> + <file path="${__HERE__}/test-data/all_fasta.loc" /> + </table> +</tables>