diff test-data/BUSTED/gene1.json @ 0:dd2d60b55e0d draft default tip

planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/drhip commit 15c654c3d27df68a47483031961ace7f5b8d998d
author iuc
date Thu, 04 Dec 2025 15:05:26 +0000
parents
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--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/test-data/BUSTED/gene1.json	Thu Dec 04 15:05:26 2025 +0000
@@ -0,0 +1,713 @@
+{
+ "Evidence Ratios":{
+  },
+ "Site Log Likelihood":{
+   "unconstrained":    [
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+    ]
+  },
+ "Synonymous site-posteriors":  [
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+  ],
+ "analysis":{
+   "authors":"Sergei L Kosakovsky Pond",
+   "citation":"*Gene-wide identification of episodic selection*, Mol Biol Evol. 32(5):1365-71, *Synonymous Site-to-Site Substitution Rate Variation Dramatically Inflates False Positive Rates of Selection Analyses: Ignore at Your Own Peril*, Mol Biol Evol. 37(8):2430-2439",
+   "contact":"spond@temple.edu",
+   "info":"BUSTED (branch-site unrestricted statistical test of episodic diversification) uses a random effects branch-site model fitted  jointly to all or a subset of tree branches in order to test for alignment-wide evidence of episodic diversifying selection. Assuming there is evidence of positive selection (i.e. there is an omega > 1),  BUSTED will also perform a quick evidence-ratio style analysis to explore which individual sites may have been subject to selection. v2.0 adds support for synonymous rate variation, and relaxes the test statistic to 0.5 (chi^2_0 + chi^2_2).\n                               \nVersion 2.1 adds a grid search for the initial starting point.\n\nVersion 2.2 changes the grid search to LHC, and adds an initial search phase to use adaptive Nedler-Mead. \n\nVersion 3.0 implements the option for branch-site variation in synonymous substitution rates. \n\nVersion 3.1 adds HMM auto-correlation option for SRV, and binds SRV distributions for multiple branch sets.\n\nVersion 4.0 adds support for multiple hits (MH), ancestral state reconstruction saved to JSON, and profiling of branch-site level support for selection / multiple hits.\n\nVersion 4.2 adds calculation of MH-attributable fractions of substitutions.\n\nVersion 4.5 adds an 'error absorption' component \n\nVersion 4.6 adds support for MSS-type models\n",
+   "requirements":"in-frame codon alignment and a phylogenetic tree (optionally annotated with {})",
+   "settings":{
+     "error-sink":1,
+     "mss":"No",
+     "multiple-hit":"None",
+     "srv":"Yes"
+    },
+   "version":"4.6"
+  },
+ "background":1,
+ "branch attributes":{
+   "0":{
+     "Node3":{
+       "MG94xREV with separate rates for branch sets":0.007049012269592678,
+       "Nucleotide GTR":0.007289662052004695,
+       "Posterior prob omega class":        [
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+        [0.06461204144565623],
+        [2.086325080203871e-05]
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+       "Posterior prob omega class by site":        [
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+     "Node4":{
+       "MG94xREV with separate rates for branch sets":0.01560819603098484,
+       "Nucleotide GTR":0.01388744473547059,
+       "Posterior prob omega class":        [
+[0],
+        [0.9700134742693405],
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+        [2.77586925402575e-08]
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+[0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99]
+      ],
+     "name":"busted.filter.default"
+    }
+  },
+ "fits":{
+   "MG94xREV with separate rates for branch sets":{
+     "AIC-c":1127.910850580984,
+     "Equilibrium frequencies":      [
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+      [0.01922996663172304],
+      [0.03420070900547616],
+      [0.014368896284083],
+      [0.03368306905822573],
+      [0.01609347460151461],
+      [0.02862242313127222],
+      [0.01202526618107644],
+      [0.03424262136543949],
+      [0.01636082378008254],
+      [0.02909790661151763],
+      [0.01222503317454278],
+      [0.04878002735358049],
+      [0.02330666869812213],
+      [0.04145116886040549],
+      [0.01741506429336918],
+      [0.01835841860430346],
+      [0.008771491191067078],
+      [0.0156001944004883],
+      [0.006554179193076294],
+      [0.01536407988586604],
+      [0.007340822446772941],
+      [0.01305573416590236],
+      [0.0054851637757677],
+      [0.0156193121609741],
+      [0.007462770186447074],
+      [0.01327261957388795],
+      [0.005576284808737427],
+      [0.02225035479396483],
+      [0.01063102412468302],
+      [0.01890739435390807],
+      [0.007943647847477694],
+      [0.02003764925766833],
+      [0.009573812850750063],
+      [0.01702713237376286],
+      [0.007153685002693248],
+      [0.01676942064321455],
+      [0.008012281919357385],
+      [0.01424993228754379],
+      [0.005986887554352669],
+      [0.01704799882132915],
+      [0.008145384126471394],
+      [0.01448665603962682],
+      [0.006086343359234239],
+      [0.02428557790460417],
+      [0.01160343585423386],
+      [0.0206368394035431],
+      [0.008670247303157035],
+      [0.01086675715317312],
+      [0.008119790817560615],
+      [0.01903413243710357],
+      [0.009094341326464849],
+      [0.01617438694822276],
+      [0.006795417266946891],
+      [0.009245418998841326],
+      [0.01644308026470771],
+      [0.006908304587387538],
+      [0.02756534742509875],
+      [0.0131704809291841],
+      [0.02342384645525713],
+      [0.009841164995614077]
+      ],
+     "Log Likelihood":-535.0231635224093,
+     "Rate Distributions":{
+       "non-synonymous/synonymous rate ratio for *background*":        [
+[0.2332468645873907, 1]
+        ],
+       "non-synonymous/synonymous rate ratio for *test*":        [
+[0.05436826671559885, 1]
+        ]
+      },
+     "display order":1,
+     "estimated parameters":28
+    },
+   "Nucleotide GTR":{
+     "AIC-c":1165.694393932368,
+     "Equilibrium frequencies":      [
+[0.3348148148148147],
+      [0.202962962962963],
+      [0.2462962962962963],
+      [0.2159259259259259]
+      ],
+     "Log Likelihood":-559.6409189392783,
+     "Rate Distributions":{
+       "Substitution rate from nucleotide A to nucleotide C":0.1057602468701381,
+       "Substitution rate from nucleotide A to nucleotide G":1,
+       "Substitution rate from nucleotide A to nucleotide T":0,
+       "Substitution rate from nucleotide C to nucleotide G":0.1465960735122673,
+       "Substitution rate from nucleotide C to nucleotide T":2.269319946484975,
+       "Substitution rate from nucleotide G to nucleotide T":0.1391184331291334
+      },
+     "display order":0,
+     "estimated parameters":23
+    },
+   "Unconstrained model":{
+     "AIC-c":1164.066233233619,
+     "Log Likelihood":-534.6092290289872,
+     "Rate Distributions":{
+       "Background":{
+         "0":{
+           "omega":236.9358471479831,
+           "proportion":0
+          },
+         "1":{
+           "omega":0.2100294329667581,
+           "proportion":0.5542688958966767
+          },
+         "2":{
+           "omega":0.255710153738319,
+           "proportion":0.4457311041033233
+          },
+         "3":{
+           "omega":0.2978621753285197,
+           "proportion":0
+          }
+        },
+       "Synonymous site-to-site rates":{
+         "0":{
+           "proportion":0.3409863833415702,
+           "rate":0
+          },
+         "1":{
+           "proportion":0.6590136166584298,
+           "rate":1.517419329012598
+          },
+         "2":{
+           "proportion":0,
+           "rate":1.52677760828329
+          }
+        },
+       "Test":{
+         "0":{
+           "omega":226.0589415365084,
+           "proportion":0
+          },
+         "1":{
+           "omega":0.04198616898833647,
+           "proportion":0.9147510556650086
+          },
+         "2":{
+           "omega":0.1430120656070995,
+           "proportion":0.08477641331245425
+          },
+         "3":{
+           "omega":1,
+           "proportion":0.0004725310225371633
+          }
+        }
+      },
+     "display order":2,
+     "estimated parameters":45
+    }
+  },
+ "input":{
+   "file name":"/home/dcallan-adm/Documents/veg/CAPHEINE/work/87/f4fe290e4b23b20d10420f0110f410/capsid_protein_C-nodups.fasta",
+   "number of sequences":9,
+   "number of sites":100,
+   "partition count":1,
+   "trees":{
+     "0":"(PP563828_1_2023_09_04,PP563831_1_2023_08_29,PP563880_1_2023_10_05,((PP564823_1_2023_10_06,PP563845_1_2023_10_22)Node4,(PP563884_1_2023_09_24,PP563838_1_2023_09_30,PP563839_1_2023_09_29)Node7)Node3,PP563832_1_2023_08_28)"
+    }
+  },
+ "runtime":"2.5.73",
+ "substitutions":{
+   "0":{
+     "0":{
+       "root":"ATG"
+      },
+     "1":{
+       "root":"AAC"
+      },
+     "10":{
+       "root":"CCG"
+      },
+     "11":{
+       "root":"TCT"
+      },
+     "12":{
+       "root":"TTC"
+      },
+     "13":{
+       "root":"AAT"
+      },
+     "14":{
+       "root":"ATG"
+      },
+     "15":{
+       "root":"CTG"
+      },
+     "16":{
+       "root":"AAA"
+      },
+     "17":{
+       "root":"CGC"
+      },
+     "18":{
+       "root":"GCG"
+      },
+     "19":{
+       "root":"AGA"
+      },
+     "2":{
+       "root":"AAC"
+      },
+     "20":{
+       "root":"AAC"
+      },
+     "21":{
+       "root":"CGC"
+      },
+     "22":{
+       "root":"GTG"
+      },
+     "23":{
+       "root":"TCA"
+      },
+     "24":{
+       "root":"ACT"
+      },
+     "25":{
+       "PP564823_1_2023_10_06":"GGT",
+       "root":"GTT"
+      },
+     "26":{
+       "Node7":"TCA",
+       "PP564823_1_2023_10_06":"TCA",
+       "root":"CCA"
+      },
+     "27":{
+       "root":"CAG"
+      },
+     "28":{
+       "root":"TTG"
+      },
+     "29":{
+       "root":"GCG"
+      },
+     "3":{
+       "root":"CAA"
+      },
+     "30":{
+       "root":"AAG"
+      },
+     "31":{
+       "root":"AGA"
+      },
+     "32":{
+       "root":"TTC"
+      },
+     "33":{
+       "root":"TCA"
+      },
+     "34":{
+       "PP563831_1_2023_08_29":"GAA",
+       "root":"AAA"
+      },
+     "35":{
+       "root":"GGA"
+      },
+     "36":{
+       "root":"TTG"
+      },
+     "37":{
+       "Node7":"CTT",
+       "root":"CTC"
+      },
+     "38":{
+       "PP563884_1_2023_09_24":"TTA",
+       "root":"TCA"
+      },
+     "39":{
+       "root":"GGC"
+      },
+     "4":{
+       "PP563845_1_2023_10_22":"CGA",
+       "root":"CGG"
+      },
+     "40":{
+       "Node4":"CAA",
+       "root":"CAG"
+      },
+     "41":{
+       "root":"GGA"
+      },
+     "42":{
+       "root":"CCC"
+      },
+     "43":{
+       "root":"ATG"
+      },
+     "44":{
+       "root":"AAA"
+      },
+     "45":{
+       "PP563880_1_2023_10_05":"CTA",
+       "PP564823_1_2023_10_06":"ATG",
+       "root":"CTG"
+      },
+     "46":{
+       "root":"GTG"
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+     "47":{
+       "root":"ATG"
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+     "48":{
+       "root":"GCT"
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+     "49":{
+       "Node3":"TTC",
+       "root":"TTT"
+      },
+     "5":{
+       "PP564823_1_2023_10_06":"AAG",
+       "root":"AAA"
+      },
+     "50":{
+       "root":"ATA"
+      },
+     "51":{
+       "root":"GCA"
+      },
+     "52":{
+       "root":"TTC"
+      },
+     "53":{
+       "root":"CTA"
+      },
+     "54":{
+       "root":"AGA"
+      },
+     "55":{
+       "Node4":"TTT",
+       "root":"TTC"
+      },
+     "56":{
+       "root":"CTA"
+      },
+     "57":{
+       "root":"GCC"
+      },
+     "58":{
+       "root":"ATA"
+      },
+     "59":{
+       "Node3":"CCC",
+       "root":"CCT"
+      },
+     "6":{
+       "root":"AAG"
+      },
+     "60":{
+       "root":"CCA"
+      },
+     "61":{
+       "root":"ACA"
+      },
+     "62":{
+       "root":"GCA"
+      },
+     "63":{
+       "Node4":"GGA",
+       "root":"GGG"
+      },
+     "64":{
+       "root":"ATT"
+      },
+     "65":{
+       "root":"TTG"
+      },
+     "66":{
+       "root":"GCT"
+      },
+     "67":{
+       "root":"AGA"
+      },
+     "68":{
+       "root":"TGG"
+      },
+     "69":{
+       "Node4":"GGC",
+       "PP564823_1_2023_10_06":"AGC",
+       "root":"GGT"
+      },
+     "7":{
+       "root":"ACG"
+      },
+     "70":{
+       "root":"TCA"
+      },
+     "71":{
+       "root":"TTC"
+      },
+     "72":{
+       "root":"AAG"
+      },
+     "73":{
+       "root":"AAG"
+      },
+     "74":{
+       "root":"AAT"
+      },
+     "75":{
+       "root":"GGA"
+      },
+     "76":{
+       "root":"GCG"
+      },
+     "77":{
+       "root":"ATC"
+      },
+     "78":{
+       "root":"AAA"
+      },
+     "79":{
+       "root":"GTG"
+      },
+     "8":{
+       "PP564823_1_2023_10_06":"GGT",
+       "root":"GCT"
+      },
+     "80":{
+       "PP563838_1_2023_09_30":"CTG",
+       "PP564823_1_2023_10_06":"TTA",
+       "root":"CTA"
+      },
+     "81":{
+       "root":"CGG"
+      },
+     "82":{
+       "root":"GGT"
+      },
+     "83":{
+       "PP563832_1_2023_08_28":"TTT",
+       "root":"TTC"
+      },
+     "84":{
+       "PP564823_1_2023_10_06":"AAA",
+       "root":"AAG"
+      },
+     "85":{
+       "root":"AAA"
+      },
+     "86":{
+       "PP564823_1_2023_10_06":"GAG",
+       "root":"GAA"
+      },
+     "87":{
+       "root":"ATC"
+      },
+     "88":{
+       "root":"TCA"
+      },
+     "89":{
+       "root":"AGC"
+      },
+     "9":{
+       "root":"CGA"
+      },
+     "90":{
+       "root":"ATG"
+      },
+     "91":{
+       "PP563845_1_2023_10_22":"TTG",
+       "root":"CTG"
+      },
+     "92":{
+       "PP564823_1_2023_10_06":"AAC",
+       "root":"AAT"
+      },
+     "93":{
+       "root":"ATA"
+      },
+     "94":{
+       "root":"ATG"
+      },
+     "95":{
+       "PP564823_1_2023_10_06":"AAC",
+       "root":"AAT"
+      },
+     "96":{
+       "PP564823_1_2023_10_06":"AGG",
+       "root":"AGA"
+      },
+     "97":{
+       "root":"AGG"
+      },
+     "98":{
+       "root":"AAA"
+      },
+     "99":{
+       "root":"AGA"
+      }
+    }
+  },
+ "test results":{
+   "LRT":0,
+   "p-value":0.5
+  },
+ "tested":{
+   "0":{
+     "Node3":"test",
+     "Node4":"test",
+     "Node7":"test",
+     "PP563828_1_2023_09_04":"background",
+     "PP563831_1_2023_08_29":"background",
+     "PP563832_1_2023_08_28":"background",
+     "PP563838_1_2023_09_30":"background",
+     "PP563839_1_2023_09_29":"background",
+     "PP563845_1_2023_10_22":"background",
+     "PP563880_1_2023_10_05":"background",
+     "PP563884_1_2023_09_24":"background",
+     "PP564823_1_2023_10_06":"background"
+    }
+  },
+ "timers":{
+   "Overall":{
+     "order":0,
+     "timer":28
+    },
+   "Preliminary model fitting":{
+     "order":1,
+     "timer":2
+    },
+   "Unconstrained BUSTED model fitting":{
+     "order":2,
+     "timer":25
+    }
+  }
+}