Mercurial > repos > iuc > medaka_consensus

@215f1e0c-27d1-4446-bca5-cb0fd6a8c054
TTGCAGTATCTGCGTCAGAATCGCATTCCAGCCGCAGGTGTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACCAAACAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATTACCTATTCTAGAATCTGATTCCTTGTACAACTAAGGTAAACTTGAACTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATGATGTAGGATCTAGGATATATCTATAATAATAATTCTTGTTCTTTTTTTATTTTATTGAATATGAATCAATACCTGTCTAAGCACACCTCTTTCTTACGCGTGAGCAATGGTTAGATGGATCTTCTGGCGGCCTTGCGCCATTCCTGTTTGTTC
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?B4-)&'%<ABC>:883110,;*-$/+%)(.(($$#%&$$#%14+6-/=1@5@A>GE@F@<B8B..0F>?AA13EJHTIDHBDAJB@BOM908=B;=>49/(?>>?>?@?(004?C57/9<B>DEEE@@@C?=>=<912+,*'1/1396;78+&$&,15(85::C@>BA>9(,</(B:;G?B;@K=<HF?JF5**+&&0/#%$;>BCB=(4<.=91<4@ADC9:AC$=9>555=3412;6;+=>?@>2$%+839@BH=CAOHFCI<.98<-0/*$%)0**()(')&$)$474)+/,'267432&&'&''''$%&'*')>?C3=;467===95489G:./5229,$$&$(&&$%%(''')+8%/0%.-%0$')&'*=566(-(685''57./4%)44+/*$$$'42:;6($$##$$$'-0(%67112$$'$())'7;:
@baf1c4f7-8f02-4c92-be5f-0431ca399c18
GGTATTACTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAGACAGCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGAGTTCGTGCACACAGCCCGAAGCTTGGAGCGAACGACCTACGCGAACCGAGATACCTACAGCGTGAGCTATGAAAGCGCCACGCTTCCCGAAGGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCGGGGGAAACACACCTGGTATCTTTTTATAGTCCTGTCCGGGTTTCGCCACCTCTGGCAGGCGTCGATTTTTGTGATGCTCGTCAGAGCGGAATTTATGGAAACGCCTGCGGCGCTGGCTTCCTCCGATGCTGCTTTTTGCTCACATATTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTGCAGGTGAGCTGACACGCTCGCCGCAGTCGAACGACCGAGAGCGTAGCGAGTCAGTGAGCGAGGAAGCGGAAGAGCGCCTATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCTGAGCGTTATCTCTCTGTGCTATTTTTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCGGGTGCGTCCAGTTTTCGAGCAGCATTCAGGCTCTGACTTTTATGAATCCCGCCATGTTGGTACGGCTTTTCTTTCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTATGATTATATCGCGTACCACTTTTCGGCTGTTTGCTGCCGTTATTCTGCGCCGCTTGGCTTTTTGACGGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTACAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAGGAGCTTTGCCCCGACACCCATGTCCAGATACGGAGCCATGTTTTGCTGACAAAACGAAGTGGAAGTAATACGCGCAGGCGGGCTATCAGTCCCCTGTTCGTCTGACGGCAGAGAGAAGACCAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCGGTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACCCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGAGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCGTTTGATCGCTATTACGGGTATCACGTGCCCTGTTATCAGACTTATGGCAGATTGGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAACATCTTTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCAGTGCGTACAATTACAGCATTATGTTAAATTTTATAGTGTCTTTAGTCATTTGCGCTATGATTTTGTAGGTGGAGTTGCTTCATATTTTTGATATAAAGTTCTTTTCCCATCTGCTAGAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGGTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATAGTTGGAGTCTTCTATTGCGCCATTCTTGTTTTTCCTGGCATGATAAAGAAGATATTTTTGTGCTTCCCGTTAATGGCTATTTCATTGTGCGAGCTTGGTGATAAATGTTAAGCTCATTTAATGTTGAAATTATCTGATCTTTCCGTGTCAGAAAAACGATTCCGTCGGCATCGATGATTAAGAATATACTTTCTTTTCCATTAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTTAGTTTGTCTTTCCATTTTATTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTTAGGAAGTGAAAATCATCATCACCCTCAACAAAAAATGACTTTTTTATAATCATTTATTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAGGAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTGGGAATTGCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTCTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTTCATCTTTCTTTTGTGTTAGTAGTTTGACCGTTTTTATCGTTGCTTCTTTGTTTATGCTTCTTGATGTGGTTATTACCGCGCTGCGGTTTTGAACTCATATAGCTTACACACTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCGTTAAAACATTCCCCTTTTCCTGAGAATAGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGGGGACACTGGCAGTTCACTTTATTGTTTATCATCGTTGAGTATTTTGTCATTACTTCAGCCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAGAAATATCGCGTCTAATATCGATGTTTTTTACCAGTTGTTTTCGGATATTACATTCAAGTGTTTTTAGTTGTTTGAAGTTATGCTCTCGAAACGCTAAAAAATTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCTATGCCACTGTCTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGT
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
@e0718894-92af-4b78-9b12-bb6fadde537a
CGTTGTACTTCGTTCAGTTACGTACTGCGCGCGCCTCTCTGTCGTCGGCAGCGTCAGATCATAGAGGCAGATGATCGGGTACGAAAGAAGTTATGAAGATGGGGAGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGATGTCGAGAGGACAGGAGTATGCGCAGAGTGCTGATCCCTTCAATACGGAGTATCCACCGTTACCCTGTTATCCGGACTTACGCCTGGCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCAGGCGAAAACAGTCTGACGCATCCTTCCTGTTTTCCCGGGTAAAAACATCTCTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAACCCGGTCGCATTACAATTACAGCATTATGCCCAAATTTTATAATTATCTTTGGTCATTTGCGCTATGATTTTTGACAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTATCTCACTGAAGCAGTCATCGTCGAAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAGCCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACGCGTGAGCAATGGTTAGATCTTCTGTGCGCCATTCTTGTTTTTTCTGGCATGATAAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCGTCATGCGAGCTTGGTGATGAAATGTTAGGCTCATTTAATGTTGAAATTATCGAATACCGTGTCAGAAAACGATTCGTCAAGCATCGATGATTAAGTATATATTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAGGGTTTGTTTTAGTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTGGTGCAAGGAGGTGAAAATCATCATCACCCTCCTTGAAATGACTTTTTATAATCATTTATTTTCTCAGTTTCATTTATCTCACCCCAGCCGAACAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCTTGTCTCTTCCCAGTCTTATGTAAGAATATATCTTTCTTTTTTCATCTAATTCGTTATCCCTTTTATATTATCAGCTGTGTGTTGTTGTAAATGTTTGATTATTATTATTGGTTTTGCTGCTTCTGTCAAGCGTTGATCCTTATCTTTGATTACTGAGTAATGAATTCCATTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGATAGCGCTCTGGCACTCTTCACCAAGCATTGATGTTTCATTTAATTCCCACTTAGTCCTATATCTAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTACTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTATAGTAATCAATTCTTCTGGGAGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGTGTTTGATAATACGACTCAACATTTGAGGACACGCTTGATTCACTTTATTATTATTATCTATCGTTGAGTATTTTTGTGTTACTTCCTGACCTTTCATCTCTTATTGTTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAAGGGTGCGTTCAGCTTTTGCTTTTAACGAGCTGCTGGAGTTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTTCGGATATTACATTAAGTGTTTTAGTTGTTTGAAGTTATGCTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTATTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCAGGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCTAAACTGAAAACGAAAAACCACCTGGGGAGGTGGTTTGATCGAAGGTTAAGTCAGTTGGGGAACTGCTTAACCCGGGTAACTGTCTTGTGCGAGACAGAGTCACCAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCTACAGCGTGAGCTATGAAAGCGCCACGCTTCCCGAAGGGAGAAGGCGGACAGGTATCCGGTAAGCAGCGGGGTCGGAACGGGAGAGCGCACGAAGAGGCTTCGGAAACACCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTTTGTGATGCTCGTCAGGGGGCGGAGCCTGTGGAAAAACGCCTGCGGCACTATTCCTCCGGTGCTTTGCTGCTCACATATTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCATGTTACCTGTCTCTTATACACATCTCGAGCCACGAGACCAGAG
+
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
@10776a55-cea8-4185-8a19-575affec5730
GTTGTACTTCGTTCGGTTACGTATTGCTGCGCGCACACTCTCTGTCATCGGCAACGTCAGATGTGTATAAGAGACAGGTTGTGCCGTTCCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGATGCAGCTTCTCACACCAGCAGCCTGTTCGTCAGCATCAGGTGCGTCCAGTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGATTTTCGTTCCCATGTCATCTGCGTTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTGACGGGCATTTCACCAGTCGAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGCGGTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTAGTCAGAACTGCCCCGACACCCATGTCAGATACGGAGCCATGTTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCAGACTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGAGACCAGGAAATCAGAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCGGAGGTGCTGATCCTTTATTACGGAGTATCACCGTACCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGTCGAAGCAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCCTTCCTGTTTTCAGGGTAAAACATCTCTTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTGAATCATAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCACTTTCTTACACGCGTGAGCAATAAGTTAGATCTTCTATTGCGCCATTCTTGTTTCACAGCATGATAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAGAGATATACTTTCTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTAGTTTTGTCTTTCCATTTATTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAGATGAAAATCATCATCACCCTCAACTTAAGTGACTTTTTATAATCAATTTATTTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTTGTTGTAATATTTGATTATTATTGGTTTTTTCTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTAGTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTTAATTCACTTAGTCCTATATCTAAAAAATCTCTTTGTTTAGTCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTGAATTCATAGCTTACCTTTTTTAGTTTGTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTGTTATTTTTATAGTAATCAATTCTTCTAGAGTTCTTTCCGTTCTGTGTTTCATAACCTTAATCATTAAAACATTCCCTTTTCCACCAGAGAGCCGAGGTTTGTCGCGATGGAGGGGTGTTTGATAATATTGACTCAACATTGAGGACACGCCCGGTTGCCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTATTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAGCTTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATGATGTTTTCCCAAAGTTGTTTTCCGGATATTACATTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACACTTAAAATTTTAAGTGGATATCTTTTATCATGTTTAAACTTACTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTCGTGATTATTGTGTTCTGGTCGTAATCTCTAAACTGAAAACGAAAAAACCACCTGGGGAGGTGGTTTGATCGAAGGATTAAGTCAGTTGGGGAACTGCTTAACCAGGTAACTGTCTTGTGCAGACGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGACCATCACTTCAGTACTCTCTTGCCAGACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTTGTCGTGTCTTAC
+
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
@0117a0ad-2480-4bf3-a343-3392923c7b59
CGTTGTACTTCGTTCGGTTACGTATTGCTGCGCGCACTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGGGGCTGCTGAATGCGGCCAAGACCGTTTTCCGGTTTTACAGGCGGCAGCTCTCGGTAAGAAGAAGTTAACTCACTGACTGATCGGGTACTGAAGAAGTTATGGGGCTGGGCGTTACAGAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGGAGTATACCCAGGGTGCTGATCGCTATTGCGGAGTATCACCGTGCCCTGTTATCCAGACTTGTAGCGAATTAGCTTCCCGGAGAGAAAACTGTCGAGAAGCAGACGGTATGGTTTCACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCGGCGAGCTACAGAAAACGATCCTGACGCATCCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTGCGGTGTCTGCGTCAGAATCGCGTTCTGACCTCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTGGTCATTGCCCTTTATGATTTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATACCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTAGATAAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGATTTAGATCTTCTATTGCGCCATTCTTGTTTCCTGGCATGATAAAGAAAGATATTTTGTGAACTTCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCGTTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTTAGTTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTACAAAGGAAGCGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTTCTATAAGTTTCATTTATCTCACCTCCCAGCCATTTCAACTGAAAGAAAAATCATCCATGTTAATTGCATTGCTGTAGGTTTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCGTCTAATTCGTTTATCGCATATTACATCGGCTGTGTGTTGTAATATTTGATTATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAAATCCATTTTCTATCATCAATGAGAATAATTGAGTCTTTTGAACCAGATTGAGCTAATGAAAGACAGCGCTCTGCCTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTGGTCTGTATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTGTGTTATTAGTTTTGATACGTTTTTATCATTTGCTTCTTTGTTTATGTTTCTTGATGTGGATTTATTATCGCTGCGGTTTGAATTCATATAGCTTACCTTTTCAGTTTGTTTTGTTTCTCCGTTTATTTCTTGTACTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTTTCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCTTTTCCTGAGAGCCGGTTTGTCGCAATGGAGGTGGTGATAATATTGACTCAACATTGGGGACACGCTTGATTCACTTTTGTGTGTTATCTATCAATTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAAGAAGTGCTTCATTTCTAAAGCTTTATACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTATTTTCCGGATATTACATTGTTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACACTTAAAATTTTAAGTGGATATCTTTTATCATGTTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATACCACTGTTTGCTTTTCTAGAAACATAATCAAAATAATATTGCCATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAACCACCTGGGAGGTGGTTTGATCGAAGGTTAAGTCAGTTGGGGAACTGCTTAACCAGGGTAACATCTTATTACGAGACGAATACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCGGTGGCGCTGTCGTGTCTTACCGGGTTGGACTCAAGACGATGGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGGTTCGTGCACACAGCCAGCTTGGGAGCGAACGACCTACACCGAACCGAGATACAGCGTGAGCTATAAAGCGCCGCTTCCCGAAGGAAGAAGGCGGACAAGGTATCCGGTAAGCGGCAGGGAATCGGAACAGGAGAGCACGAGGGAGCTTCAGGAAACACCTGGTATCTTTATAATCTGTCGGGTTTCGCCACCTCTGGCGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGACCGGAGCCTATGGAAAAACGCCTGCGGCGCAAACCCTCCGGTGCTTTGCTTTTTGCTCATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGAGTGAGCTGACACCGCTCGCCGCAGTCGAACACTGACCGAGCGGCCAGCAGTCCAGTGAGCGAGAAATGAAAAACTTACTATATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCCACACTTGGCAGCCTGTTCGTCAGCATCAGGTGCGTCCAGTTTTTCGAGCAGCGTCAGGCTCAAACTTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGTGCTATTTGTCGGTAATTCAGGCTTGCTGACAGGACAGGATGTCACAATTGTTATACCGCGCATACATGCGCTATTACAATTACCCTGGTCGGGGCTTGCCCATTTACCCATGTCGGATACGGAGCCATGTTTTATGACAAAACGAAGTGGAAGTAATGCGCGCGGGCAGACTATCAATCGCCCTATTTAGTCTGACAGCAGAAGAAGACCGGGAAATCAGAGAAAAAGGGCTGCTGCTGTCTCTTATACACATCTCCGAGCCCACGGAGACAGAAG
+
$%%%*.../146C2D&/;@-AC-9AB;<A:,0&&*((8,8+=8:8;9@<E;>F@:C5:7;>G<*:8==441=?=4-<67=///;7:6;987&''5/069567@==8%(3=DEM6*'$<A@-5('4*/9@E;<<23081&&&;8><=AEEF;@KH;>I2(B$+6@7BC>?=.95CHF;;**+&'$*,-?@I;//501:3.*%;;JJGCC=>:89AA832=;A@<A15=>B24344)1<*&&'8)&/*;C@?EH@8?5592<@=?12(.&72A(653DD><L@BCGA--?5ED<BA7-'10))0-445588)0G>C<77)1<C;6746962&%)$58:76%*+*)$&%%$*22216..$77=I?CEDFEE<5859:?EAA88JJ14)%%*&(-/154%%3$.+%$/'&#$$$:C?<@>?002?HAH=@B56B33B;:89?>E@)-A.3:7?<>D/95>AC6BAD>8=;A>?>>891/8.(*&42?)2)$/().,%)%-*8A65.2:'+?45293124(1,,)59697E>>ACAC9@DIE>:,4*-/;<A<6$&%$'(-%$&%(/:7788:?LHGB<A;>F:<26;?;CD2C0GAGGLJFFFGBA?@DFB<BCIC;<?2>?=/0'?9<=;;AA<?3,?77A5/98;;269>@;<@?=>DA;=@998.**564/783.9-9<5>8??I@()'21-.=>667B79?FBFIDFI@>:E@CCFC=:?@F::;JH?7@E@CFF547412((8;<=D:48359>7;856<<8//6<=8=?<D?;9=-=A;=<=ECB2).4>><D<%%.(*41.'*$25681;:;45:LNJEE587:<8A?FID;D5<8-:?=AB<:+(%:@.2'?<@DAA81@A=D688==::986?>A/3.-/4.3448AC>'95'6C@;G@<:1/%$&%%)-49;::C=@@8:E@<=:>?9<4*'$)=>>89==8546.46779<=:@A@>QN>??>;7*,0346<=9;5;>ABCF<@;K0)?44?CHF?GEGB:?;A-4E<6-(%))')0()/149:8969:B=@?PGHA7BBBE72/@&->>;76:ABH=CDC>>C68)%&/,=BA82>?F@7<@BPG??@=??-+6<E?7@A>=FG88=?CFH6BEBB899CF@E89>DFB=AD;*233=9=46.&*-.&%32.3/,8FEE=;9;C9:<9A>26=?@=8AGFDAADFOFWNHEFEE<D@JKC;CC@=5822/*',CF>:>ACF?;>;@;;9@8@?D?A@=HI;@..,,,,3'(;1IBADD@=@EA88>3$%%+/66:=>A>7,&29?DLEA?@:8<788/3=CB45C=CC@C?@?:;HD>>8<<>CEA=/A:<CCEB;AEPF@82018A@6@35@@6-')%&(%%)+##*%/$)+,,0-'504076>87NHKJFLC8<6-2/*8>1;CGOHD::99<@CA<:3988(8=AM><46B7@C<@MIFE@F6,,+,(275<7-.>K>@JBEEN>5,?6//+B67:/.-;DA,8?8=.E=?KJRIHH5-%2*,;4+,6:855886519@1.>@=><4)$&&.5<:<B**?BEBD@==@=9/<<;C>ADE@ACAA@<>>*)%4;:=?9<=CMMFECD89A>=<72=5:==<=?E:GE?DMEG>2CB18;?=4/0,/7,/'.>;=..83B8>6>;2DM;71:JI9>=E=:<5;?>;7>?@AEC:A>:94-=6>/1&(*=*+A=76-(83@<]J:201(*1G45689:;6/=?2'%59:A?E:84438-0&CE:32/)-2,2==@/49<A<;89ACAE9/*=>?@7:<>@E0$%)1BE9@B@;$35>14:=;IIEBEEIDND<4/=EDJHF;ED>:168;;9534B@DA;D25AA.E<>:/199=IA84@FB?3;9BCA>;@ABC/902-;=<=6<CF?A98;DFCAAEIH?B99DL@;>?G:684;9&.66:347(112:360%))%$,-)78:@?BCGDC?E>>J@CE02>GE>A?A;=>>;<?8;;>@DB(0(&&5<=<B?52:%%%6<3@BBFCA>9'./35?<>59.339<:<GC945)4=3(66$,7(,JC?EGGCGFD68740)(44854-A=22<?EG@=><?2<5576HH?=><=5C@HD>GG/)6:6DHF%*++'2//;??:=??>>?B<-;??;;8;8;FHGDG+D)39?@?DC37BKEPD<4;97@6@<?.++$*;?>@<>7;==>??BC95?9;D<::HC$'($'%(/,&/27=$)/3:/()-?B;<>%@C=>=7<8:OB7>>A?@@.-$'+4/673426?;B?BFB?>11-888:FKI;<@:@?@?A?::RLPLB<@;:6?AGAIJGCPG>A>8<7;.BEE:;=;:4::>GGCAA?B@??>GC??ACF<CDD<GFKE@C>20:>==-$%3<;9=49;4$$34:><9;60*%''-59:<;<;@9/.;++0/-24?:7116HBEEL;<:CDD?DIOC==1@:EGFI?:<&*$;<-0/300F?D77GF>GG5?<F@C>;<83+3>@=?C&*3<@C?4<+5==9$$/;@?=<443.158.2&859BEBD>6::4+2HKG@D0*3):03$'.8;A?DA9:===7/&1&..().,/%$+%$&&0&(8?4&&'$&&-126;AD<''-%6(4(+=00%<:<61/445((0>??7G=9:68458<95:>=D;;;<C?>@>:EDH=E:C4A-AEFK:01@>>EEJCH>8:<>A$+;/8:&%787BAFD>?J=1B:;8EE=;?=8.7674:03*>*0,/A<A<AH=DF0E<B-)1A1.(B58<<=A==,'9))+>B=3*;37,+$%&&--,(***+0;+47'&.8655*'378??::=D75/01,%%&199<77<?>?;/4,-@@?.4:@D/4./*1-3%-$)%26=>CG?+,?>A@89FDIJHKGA;@93>../'->)022*'887*$75-..&2/-)0:;+4-23/8<=C><8+/1=<CBCA89(''%()5?24>=ECD78-4&)E@;,)'++4;97CEGPAMHF:;<4DDEHCA<-%622,%%&-*.*$.,9:::>9:56=8;@?@--&'$#&%%#1557-6((6'$$%$$#**88;54;,667EF>ADE;>>@@GGFC>@ME>;;>PGGD@6?CHECE@>:DB??DGC9''-7561@;;7?=<D<>>CEDGHEEDF5+$9/7&&0+)))>=;95,63$'$&3&($%%%7,919)'),,3-.3411-&&'##$(11/;B:2???;559E)238>87.23:A@EDEF-;>=>8B3+7?F@++181--/998CCAF92<>A22<3*/,,3+>?B?<=:<E=JJEBC@HC@DFDFJJBAFHB;F@AB7<<CCLHCAB9<7DGC+$9(,%8<=@C>%<+,3%%'%-&%667<>:9BF?5,<=>>3*;*B:<<$$;1>EFOK@<7/4=<56=<:4CED,'$')5556645>>=B<FJJCEA;99=;:498*)/5@GG>=A<9;6(().%)A?@CHIN18:LHM?>B<97HBFB6/=28?D?>FC>@7C>%'$&'',1745<@=515.<=2:@@@BE:@<DGMLWNA00E??5@A6BCDAADC-,GE8D>=<FC??;A<,BABDF=<<1,3''=675610+(:BA89/**ABHBFGCG:<2'3&$%%'+;83;*.4.2-06).GCKK:;AJI:3:A67/=416+%%#(%'%)<>>30/9<>:DGD?BF9/-=33<4<=699;)44EA9:./$)$(3-%%'$$$#$##$(002:<.&>&+>68@25'6=<??@=<=.&,2A>IJE00*(+/>04+'****#$.(-'4%*,,%&)1783=/01;---))%)*+$)9;>B6+')-++43/0*ACCC).81975?:9;%9I0/&,=BBFAAF>:@:;=G?=@?>C7<?@>@A)=--CGIJ4=)+$/1*)%(%#
@79261c62-2969-4fd3-b781-0fbad35b5124
GGCGTTGTACTTTGATTCCAGTTACGTATTGCTGCGCGCGCACTCTCTGGTCTCGTGGGCTCAGGATGTGTATAAAGAGACAGGTTCAATCCTGACGGCGAAGAAGACCAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCGGTTTACGGGCGGCAGCTCTCGGTAAAGAAGATTAACTCTTCGACTGGAAGTGATCGGTACTGAAAAGTTATGAGACTGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGAGGCGATGTCGGGGACAGGGGGGGTATGCGGAGTGCTGATCCTAATGCAGATATCACCAGTACGCCCTGTTAAATCAGACTTATGGCGGATCGCTTCCCGGAGAGAAAACGCTGGCGTCGAAAGGCGGACGGTGCGCTGAATTTTCCATCAGCTCGAGTGATCACCATTCGCTTTCATGCATGGCTATGCAGCGAGCTGGCAATCTGACGCATCCTTCCTGTTTTCCCGGGTGAACATCTCTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAACGCGTTTCAGCAGTGCGATACAATTACAACGATATGTTAAATTTTTATAATTGTCTTTGATCATTGCTATATGATTTTTGTAGGTGGGTTGTTTCATCATTTTTAGTGTAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCCATTGATATACCTATTCTAGATCTGATTCCTTATTACAATAAGGTAAACTTGAACTTTGCTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTCTATTTTATTGAATAAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAAGATCTCCTATTGCCCATTCTTGTTTTCCTGGCATGATAAAGGAAAGATATTTTTATTGCTTCCGTTAAATATTTCTATTTCATTATGCAGGCTTGGTGATGAAATCATTAAGCTCATTTTTAATGTTGAAATTATCCGATCTTTCCGTGTCAGAAGAAGAAAACATTGAATTCATCGGCATCAGTGATTAAGAATATACTTTCTTTTTCGTTAAAGACTCTATGCTTTTAAATGCTCTAGGGTTTGTTTAGTTTTGTCTTCCACGTTTTTATTTTTTCAACATACGTCGTTATAGTTCATTCTGTTTTCCAGTGGTTATATGTAGAGAGTGCTATGAAATCGTCATCACCCTCAGCGAGAATGACTTTTTATGAGAAATCATGTTTTATTTTCTATATATGCTATCTCGGTTTCATTGTCTCACCTCGTCATTTTTCAGCTGTGGAAGAGTCAAGATCGTCCGTGTTAAGAGTTGCGTTGTAGCTTTCCGCCTTTGTTTCGGTTAGTTACGGGATTCTCTAAGCGCTTACGTGTCTGGCGCATTTACCCATTTAGGTCTTATTTGTTTGCGTTACGCTGC
+
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
@b45a17f1-0345-4fb6-a33c-200285e4e92d
GGTAGCCCGCTTCGTTCAGTTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGCATTATAAGAGACAGGACAGGAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTTTCCGGTTTTACGGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAGTTATGAGACTGAGGCGTTGCAAGAAAAAACTCTTTATCGACGGCAGAAGCGTGTCGGGGACAGGGGAGTATGCGGAGGTGCTGATCAACTATTACGAATTATCACCGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACGGGCGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAAGCGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTGGGTGGAGTTGTTTCATATTTTGATGTAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATACCTATTCTAGAATCTGATTCCTTATTACAACCCGGGTAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAACGTAATCAGGATCTAAGGATAACAATAATAGATTCTTGTTCTTTATTTTATTGAATAGATCGTCTATATATCTACAAACACCTCTTTCTTACGCGTGAGCAATGGTTAAGATCTTCTATTGCGCCATTCTTGTTTTACGGCATGATAAAGAAAGATATTTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAGCGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAAAGACTCTGTACTTTTAAATGCTCTAAGGGTTTGTTTAGTTTGTCTTTCCATTTATTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAATAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAGTGACTTTTTATAATCATTTATTTTTCTCAGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTCTTTTTCATCTAATTCGTTTATCGCACATATTATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTTTTTGAACTAAGATTGAGCTAATGAAAGACTTTGGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTGGATTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTTCCTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGTGTTTGATAGCTATTGACTCAACATTGGGGACACGCTTGATTCACTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCCTGGCCTTTCATCTCTTATTGTTATGGACATTTCTTTTATTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAAGAGATGCTTCATTTCTAAGACTTTTACTTTTAACAGAGCTGCCTGAGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTCGGATATTACATTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACATAAAATTTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATATCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAAACCACCTGGGAGGTGGTTTGATCGAGTTAAGTCGGTTGGGGAACTGCTTAACCAGGTAGCTTTATCTTGTGCGAGACGAGTCACCAAAACTGTCCTTTCCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCATGATCAGGTGAACAGGGGTTCATTGCACACAGCCCAGCTTGGAGCGAACGACCTGCACCGAACCGAGATACCTACGGCGTGAGCTATGAAAGCGCCACGCTTCCCGAGAGGGAGAAGGCGGACGAATCCGGTAAGCGGCGGGGTCGGAACAGGAGCGCACGAGGGGGCTTCAGGGAAACACCTGGTATCTTTATAGTCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCAGGGGAGCCGGAGCCTATGGAAAAACGCCTGCGGCGCTGCTTCCTCCGGTGCTTTGCTTTTGCTCACATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGAGTGAGCTGACACCGCTCGCCGCAGTCGAACGGCCGAGCGTAGCGAGTCAGTGAGCGGGGAAGCGGAAAAACACTGCTATGTGACATTTCTCCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGACGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACCTGTCTCTTATACGCATCATCTGGCGCTGCCGACTGATGTGAGAGAGTGTAGAGCAATACGTA
+
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
@df626962-99b4-4ffe-b41f-71df1a5536ca
CATACTTCGTTCAGTTACGTGTTAACACGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAAGAGACAGGTATCACCGTGCCTGTTATCGAAGACTTATGGCAGATTGGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGAATTTATGAACACCGTAAACACGGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATGGTGTCTTTAGTCATTTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTACACTGAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCATGGCCACCTTCAGGTAAACTTGAACTTGCTTTCTTTTCATTATTTGGGTAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTAGATAGATCGTCCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGATTTAGATCTTCTATTGCGCCATTCTTGTTTCCTGGCATGATAAAGAAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTGGCAACGGTGATGAAATGTTCAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAGGAATATACTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGTTGTTTTAGTTTGTCGCTTTCATTGTTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGGCTTTTTATAATCATTTATTTTTCTCGGTTTCATTTATCTCACCTCCCCAGCCATTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTTTCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCTTTATTACATCATGGCTGTGTGTTGTTGTAAATATTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCATCAATGAGAATAATTGAGTCTTTTTTGAACTAAGATTGAGAGCTAATGAAAGACAACGCTCTGCTTACTCCCTTCACAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTCTTGCCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTTAGTTTGTTTATTTCTCCGTTTTATTTCTTGTACTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGAGTTCTTTTCCGTTCTGTGTTTCACTAACATAATCATTCGACATTCCCCTTTTTCATGAGAGCCGAGGGTTTGTCGCAATGGAGAAGTGTTTGATAATATTGATAACATTGAGGACACGCTTCGTTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTGATATATCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAAGAGATGCTTCATTTCCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTTTACGTCATAAAATGAAAATATCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTCCGGATATTACATTAAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTCAGAGAGCTTACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTGGTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAAACCACCTGGGGAGGTGGTTTGATCGAAGGTTAAAGTCAGCTGGGGAACTGCTTAACCAGGTAACTGTCTTGTGCGAGACGAGTCACCAAAACTGTCCTTTCCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGTTCATTGGCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCTACAGCGTGAGCCTTTATGAAAGCGCCACGCTTCCCGAAGGGAAGAGGCGGACAAGGTATCCGGTAAGCGTGGGAGTCAGGTCAGGAGAGCGCACGAGGGAGCTTCCAGGAGCAATACGTAAC
+
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a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
@44d22ce8-5a8f-4033-9140-aea47631c00f
GTTGTACTTCGTTCGGTTACGTGCTGCGCGCCTCTCTGGTCTCGTGGGCTCGAGGATGTGTATAAGAGACAGCTTTCATGCATAGCTATATGCAGCGAGCTGAAAACGATCCACGGTACCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTGCGGTGTCACCGTCAGAATCGCGTTCAGCGCGTTTCGGCAGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTTCATATTTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCACAATACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCCGTAATCAGGATCTAAGGATGTAATAGATTCTTGTTTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGATTAAGATCTTCTATTGCGCCATTCTTGTTTTCCTGGCATGATAAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCAGGCTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACATTCGTCGGCATCGATGATTAGAATATACTTTCTTTTCCACGTTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTAGTTTGTCTTTCCATTTATTTTTCAACATAAACATCACATTAATTCCTTCTATTTCAAGTAGATTACAAGGAAGTGAAAATCATCATCACCCTCCCAACGAAAATGACTTTTTTATAATCATTTATTTTTCTCGGTTTTTTTTTTTTTTTTTTTAGGTACATCTCACCTCCCAGCCATTTTTAAAGCCAAAGAGAAAATCATCCATGTTAAATTGCATTTGCTGGGTTTTGAAAATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCAGTTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTTGGTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTGCACAGTAATGGATTCCGTTTTCATCATAATATGTGGTATCTTCAATGTGGTGGTGTTTGGTGGTTGTGGCGGTGGCGGGGAGGTGGAGGCGTAGTTCGTTGAATTTGCACATATATACCTTACCATATATATACACCTTCCACATTCCCTGTACATGAAATGGTGTTTTGTTTAATTCATAGTCCCTATATCTAAAATCTCTTTGTTTTTGATCTGTTGCTATTATTGCAATATCGTTGAATTCTACATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGGTGTGGTTATTATCGCTGCGGTTTGATTCATATAGCTTACCTTTTAGTTTGTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTGTTATTTTTATGGTAATCAGTTGTCTTCTTAGTTTCTTTCCGTTCTGTGTTTCACTAACCTTAATCATTTTTACCACCTACATTAAAACATTCACAGCCTTGCTTTGCTTGCCCCTTTCCTGAGAACCGAGGGTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTGAGGGACACGCTTGATTCACTTTATTATTGTTAGCATCTATCGTTGAGTATTTTTATTATTGATTTGTTGCTGACCTTTCATCTCTTATTGTTATGTAATAGTATGGACATTTCTTTGGATGTGTCCATGTTATGTAAATAATGGCTTTAATCAACAGATGGGACTTGGCTTTGTTTAAAGGGAGGAGTTCTAATGAGCGCCGTTTCTGAAGGCTTTTTTACTTGCGAAAACGGGCGCTGGCATGGTGACTTTAGTAACCGTTTTTTTACCTGTTGTTGGAGTATATGTCGTAAATGCTGAAGTATAACGTTATACTCAGGTTCTATTACTGTGGTATTTTTTACATTCAAATATGTACACTCCTGGCGTATCATATCGTTTGGATTATAATAAACGGGTTCTGTTACTTCACACCTACAGCCTTCATACCTTATGGTGGTTTTTTTTACTGTTGGTGTGTTTTACCTGGTACGATGGTGGTGGTGGTGATTGATTTTTGGTGGTGGCGGTGTTTTATTTTTCTTTTTTTCT
+
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
@664bfb94-6fdc-439e-9452-d07449ae7b26
CATTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAACCCAGCTATTACGGAGTATCACCGTGCCTATTGTATCAGACTTATGGCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTCAGCGGTGCATTACAATTACAACATTATGTTAAATTTTATAATTGTCTTTAGTCATGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTGTTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGAGATGTAATAATAGATTCTTGTTCTTTTATTTTGTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATAAGTTAGATCTTCTATTTGCGCCATTCTTGTTTTTTCCTGGCATGATAAAGATATTTTTATTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGTTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTCATTTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTATTTTAGTTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAGAAAAATAAATGATTATAAAAGAGATCATTTTCGTCGAGGAGCGATGATGATTTCACTTCACTACAATCTACGAAATAGAGAATTAATGATGTTGGTGAAAAATAAATGAAAGATGAAGCTCAAACTAACATAAGGCGCATTTAGCGCAGTCGCAGCTCGAAGAAACAGGTCAAACTCATCGACCAGCAATCGTTTTCTGACGCGGAGCGTCGATAATTTCAACATTAAATGAGCAACGACTTCTCACCAATGAGCCAATACCGTAACAGGCTAAAAAATATCAACAACATCATCTCGAGAAAAAGGCAAGAATGGCGCAATGAAGATCTATTGCTCGCGCGTAGAAAGGAGATGATTTAGATATATGAACGTTATTCAATAAAATGAGAACGGAATCTATTATTAATCGCTTAGATCTGATTGCGCTTTTTACTAATGAGAAGCAAGGATTAAGTTACCTTAGTTAGCAATAAGGAATCGAATTCTAGAATAGGCATATCAATGAAGAACAAAACCGTGATACGGTGGATAAGAAATTTATATCAAAAAATATGAAACAGCTCACCTACAAAATCATAGCGCAATGACTTAAAATTTAATTATAAAATTTAACATAATCTTTATTAATTAACACGCACCATCTAGTACCTTGAACACGATTCTGACTTGCATTTACATGTTTTTAA
+
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
@8de7e0c7-c712-432a-a9d2-58d6f1fe3440
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTATAAGAGACAGACTCACTGACTGATGATGGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGAGGACAAGGAGTATGCGGAGGTGCTGATCGCTATTACGGAGTATCACCGTGCCCTGTTATCCAGACTTATGGCAGATTAACTTCCCGGAGAAAACTGTCAGCAGACGGTATGAACACCGTAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCTGAGCACATCTCCTGTTTTCCCGGGGTAAAACATCTCTTTTGCAGTGTCTGCGTCAACGTTCAGCACCACGTTTCAGCATTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTGGCCACAACTAGGAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTGAAGCGTAATCCGGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAAAGATCTTCTATTGCGCCAGTCTTGTTTTTTCTGGCATGATAAAGAAAGATATTTTATTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTTAATGTTGAAGTCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAAATATACTTTCTTTTCGCAAAAGACTCTATGCTTTAAATGCTCTAGGGTTTGTTTAGTTTTTGTCTTTCCATTTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAACATCACCCTCAAACAAAATGACTTTTTATAATCATTTATTTTTTCTCGGTTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAAGATATATCTTTCTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTTTCTATCATCAATGAGAATAATTGGAGTCTTTTGAACTAAGATTGAGCTAATGAAAGGCCAGCGCTCTCGCCTCCTTCACCAAGCATTGATATTTCATTGAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTGTGTTAGTAGTTTGATACGTTTTTATCGTTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGAGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATAAAACATTCCCCTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTGAGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCACATTCCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAACTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAGCTTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTTTCCGGATATTACATTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACACTTAAAATTTTAAGTGGATATCTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTAGCAATACGTAACT
+
013<40<@851:>1.<@;4:375//.).03---''')&-7=@DA<@51@8?:4<5>;405)(/=@D;;;<;=/68==;;A?8?>1**%$%$&')57<6787<+1:4'&82;?;?@;;.16-.-&&4<8=663:AC7=@=<>EB=1=;:,/:8;86/>;858198,)$$'&'073.*.48-1::868965@34=45.(<13'15/+,),/2;6;;/+)035%%B;>?<AA>D&.6413(134'',(-=+**''01,3=4/8.-141FA+2@EA008?453/.9/;=%2/-.,.<=)%5$%09?7@4))+AC868G.0-0+(2,+41:76/4667333/0//2<+($&2%/%$(&%-/*,.KC,19),&$''-647@=CA=E?>;3)%:BC>AID?0-)&%49I@9111%%+#.-9;=20,*--0(-,5:8FEFG?8E0A==@E?AB@:<9;:82,,$&$(@=>TNK???B9;A@CCBKGABABDGF=6;45A58*=DF6CF8B5DCDGPMIEBBCBBACCDD=HB?7/55ACB>=:9<@<67<?A@;42<57A?9=<<9:=FEMD>GE>LC>78<>?;:0)//.%77902.0.*9.>>A>7845**)*57:;639.-$*,;:<4=?@EFF>EHKJ88>AD=D@I4887:<DC9&*')$'),9?;>@..>%,,(--.349@FFCC@D@?C=?8E?>@ADBDD:JGNF?ABEEDCLFF@F3B+7/0-99;;-=/:4545786:*/1<C?B=@=93?4C732:401-./04EA,-&2.(0.-$'&&'%%$$$'&&$$=?A?RLF4C6<=B>CA>===,3?A/*<.&?95/((*/035:>=GG<=G=AC@<B@HC//374:<55>EFC/4/+*2477<03DB566AA?8<;;/:;449/+%&*&'4?EABBI>43((49;60A=>>941/&,318<55@D;>1&($%%*&+-4:GEEAC,+$%692&/??;>710.-126>?A;,)09*)(19NJ?3CAAB?CFQJF>33A@J<@CHGKD8JJSK>@AB@DACD>891(%41122888??CEC?@B@/00<;=23=,8?@1,)./*/,,;:-,243010.**-.*$*.55889>C?IB59>=?<2;>A?<@?MHEI>9<+2AB@@89>>=A?CA=947:5CEDDEC@??F6>3/48::CA72(@HMDH;<B<?BFBG??50,,5;@DEI>ED=1,0368-.279BC<?BH@<==:10%%&()89>C@=??:;)*25,4>;<DGC;>9G@<<:67:7)(/=87CC?62>..'.,89;=@@D<?AE:?:;:88E@FF9AD=8974,,=?655F/'&,)*359GEGEB%45;=CCHE@;A>@;)?=?AA<58+()-42AADDJHCBFCB><74-00084%'.%*CCCC?9<93?;FDFCHF<GJC+,+,%'87).DDQB@FG=?66<::9.-.31*+1221(,%#&($&26710&'((.596870/:<><AHIJGGBDBAE611,(3(48.E;<>@=789JD561<7FIHBA>>8;@<EHJC<=TKDD=?=-CD?AKBC8013>C<<A?:=;EFEGHJFHG=@@;A>BAB=FDGD2/->@C,56>@HF-LJO:34+*28<6EAPKBA:@?ED@>>>BFD??B?AB?B>EC=8:<);?;,15:<=>A=?@HHCFA@B,;?B=85>047?=BFC?D?AC<F3;KGB+?@@BDA?@=;@99::F=>FDLF;46AELBEAMK@KDD>C;?6<;@AGA>GA8<<FCI=B@AC=A=9998=;0:93.A:::@ALDB<45/--%847<A@HDE9;9><=?<BD@A-3*24>A@>?BA.&<%5:=<A@569::;77;02064'(%46782ADQPG34;5?<<=:8>77B@>@77;,,9>@DADC@-'19:;>6:26':;;8:54),,-.+).95%%*42;62<9=A=ABB88:BA22>CFJHUOF@DD=:=7410('&$%$&&5C>@<>?<EBAPE.A>:?=BJC9?DK=KGG9;DH>1?:;DFADDCC@894<64('(-0;<BCFGA>3/-67;H?ABFD>MJA99:'655848CE@?DA4&;8:97AHHKC>53678:9:2=-6-/4*)0.0=F;QG4**96?77CEDKCDCDAE=72B<=;<@B@>7-*<9?DA<9??67778/:@4)56EDCC)2:>EFAMJCFHRK:;4AB89M8.>AA>EECA;9/>01('&37-,0'(:8;9567BC:AAB=;8::C3537<<<;:7@<;3:79=;ABHBQI;;=2>1;AHJNBE?GB;5;9HIHD>;.*8=?CCDGAA6>GH;1DAHC54>B:=E>B<((ABGBFD>>B;LIJBA.8)-(/6=@@?8<:;C::=?;;74,7::;EFJD//59:B@7%&**2;;A>;1%('(45?I?=<;(:>@>64%(
@20d51e2b-f994-479d-b24f-2f7ea0b4f7e2
GTTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGGCGGTGCATAATACGGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCAGTGCGTACAATTACAGCATTATGTTTAAATTTTATAATTGTCTTTAGTCATTGCGCTGTAGTTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAAATCGCTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAATCAGGATCTAAGGATGCTTAATAATAGATTCTTGTTCTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACGCGTGAGCAATGGTTAGATCTTCTATTGCGCCATTCTTGTTTTCCTGGCATGATAAAGAAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCAGGCTTGGTGATGAAATGTTAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAAAGACTCTGTGTTTTTAAATGCTCTAAGGGTTTGTTTTAGTTTTGTCTTTCCATTTATTTTTCCTTCAAACATCGTTAATTCCTTCTATTTCCAAGTAGATTGCACAAAGGAAGTGAAAATCATCATCCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTTCTCAGTTTCATTTATCTCACCTCCCAGCCATTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCGCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTCTATCTCATCAGAAGCTGAGAATAATTGGCGAATTCTTTTGAACTAAGATTGAGCTAATGAAAGACAATGGCGTGCTCTGCTTACTCCTTTACTAAACATTGATATTTCATTTTAATTCACTTAGTCCTATATCTAAAAAATCTGCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTTAGGTTACCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTTGATACGTTTTTTTATCACGTTTACTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTGAATTCATATAGCTTACCTTTTTTTAGTTTGTTTTATTTCTCAGTTTATTTCTTGTGCTTTTTGTGTTATTTTATAGTAATCAATTCTTCTGGGGGTTCTTTCCGTTCTGTGTTTCACTAACGCTAATCATTAAAACATTCCCCTTTTCCGCGAGAGCCGAGGGTTTGTCGCAATGGAGGGGGTGTTTGATAATATTGACTCAACATTGAGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCACGACCTTTCATCTCTTATTATTGTTATGGACATTTTCTTTGGATGTGTCCATGTTACTTAAAATAGCTATCCCAAATGAGTTTCTTTGTTTAAAAGTGCTTCATTTCTAAAGCTTTTACTTTTAACAAGAGCTGCTGGAGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTTTCGGATATTACATTAAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTCAAAACACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTGCATCACTATGCCACTGTTCTTTTCTAGAAGTATAGTAAAATAATATTACTTTATAGTCCTGTTTGGATGATTTAACCAGTTTGTGGAGTTGCTTCTTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTTGAAAACGAAAAAACCACCCTGGGGAGAATTGGTTTGATCGAAGGAGATTAAGTCAGTTGGGGAACTGTAGCCAGGTACGCTTTGTCTTGTGCGAGACGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTCTTGAACCTCTCGCACATCGACTTTTACCAGTGGCTGCTGCCAGTGGCGCTTTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATGGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGTTCATTGCACAGCCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCTGGCGTGACTGTGAAGCGCCACGCTTCCCGAAGGAAGGCGGACAGGTATCCGGTAAGCGGCGGGGTCGGAACAGGAGAGCGCACGGGGAGCTTCCAGAGGGAAACACGCAAGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCAGGGGAGCCAGACCTATGGAAAAACGCCTGCGGCGCTGGCTTCCCTCCGGTGCTTTGCTTTTTTGCTCACATGTTCTTTCCAGCTTTATCCCCCAGATTCTGTGGATAACCGTATTACCGCTTTTAGTGAGCTGACACCGCTCGCCGCAGTCCGAACGACCGAGCGTAGCGAAGTCAGTGAGCGAGGAAAGCAAACACTTCTATGTGACATTTCTCCTTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTGCTTTAAAGCGTGTCTGGATGCTGTTCTGGGTTCTTCTGCGAGTTCATTGCAGCTTCTCACATGGCAGCCTGTTCGTCGGCACGCATCGGGTGCGTCCAGTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTCGACTGTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGAGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGATGCAGCTGTCGATAATTCAGGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCTAGTCAGGGCTTTGCCCGACACCCATGTCAGATCACAGACCATGTTTTATGACGAAACGAGTGGAAGTAATACGCTGAGCGGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAAGAAGACCAGGAAATCAGAAAAGGCTGCTGAATGCGGCAAGACCGTTTCAGTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGGAGTATGCGGAGGTGCTGATCGCTATTACGGAATATCACCGTGCCCTGTTATCCAGACTTATGGCAGATAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCCTGTCTTATACACATCTCCGAACCCACGAGACCAGAGTGCGCGCAGCAGTACGTAAC
+
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
@83ecde3f-1fae-49a6-bab2-56e0186cd33c
TTGCAGTGTCTGCGTCAGAATCGCGTTCAACGCGTTCAGCGGTGCGATACAATTACAGCATTATGTTAAATTTGTATTTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTATAGGTTGTTTCATATTTTTGATATAAATTCTTTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAGCTTGAACTTTTTTGCTTTCTTTTCATTATTTGGGTAAGCGCTAATCAGGATCAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATCGTAACCTCTTTTCTTACACGCGTGAGCAATGATTAGATCTTCTATTGCGCCGTCTTGTTTCCTGGCATGATAGAAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCCGTCGGCATCGATGATTAAAGAATATACTTTCTTTTTCGATAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTAGTTTTGTCTTTCCATTTATTTTCAACATAAACATCATTAATTCCTTCTATGATAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACAAAATGACTTTTTTATAATCATTTATTTTTCTCGGTTTCGTTTATCTCACCTCCCAGCCATTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTGAGATTCCTTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTCATCTATTCGTTT
+
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
@acb5ca54-a9a8-4852-b317-827cb378967a
GTTGTACTTCGTTCAGTTACGTATTGCTTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAAGAACAGGTTAACTCACTGACGGTGATCGGGTACTGAAAAGTTATGAGACTGGGGGCGTTACAGGAAAAAACTCTATCATTTGGCAAGCGTGTCGGGACAGGGTATGCGGAGGTGCTGATCCGCTATTACGGAGTATCCACCGATTGCCCTGTTATCCAGACTTATGGCAGATTAAGCTTCCGGAGAAAACTGTCGAAAACGGGTGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCCTTTTCATGCGCCAGCTATGCGGCGAGCTGAAAACGATCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTTGCGGGTGTCTGCGTCAGAATCGCGTTCAGCGCAGTCAGCGAAGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTTGCGCTGATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACGCGTGAGCAATGGTTAGATCTTCTATTGCGCCATTCTTGTTTTCTGGCATGATAAAGAAAGATATTTTTGTGCTTCCGTTGTGGCTGTTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTTAATGTTGAAATTATCGATCTTTCCGTGTCGAAAACGATTCGTCAGCATCGATGATTAAGAATATACTTTCTTTTCATTAAAAACTCTATCTTTTGATGCTCTAAGGGTTTGTTTAGTTTGTCTTTCCATTTATTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAATCATCATCACCCTCAACAGAAATGACTTTTTTTTATAATCATTTATTTTCTCGGTTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTCATCTGAATTCGTTTATCGCATATTACATCAACTGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCTGTAGAATAATTGGAATACTTTTTGAACTAAGATTGAGCTAATGAAAGATGGCGCTGCTAACACTCCCTTCACCAAGCATTGATGTTTACTTAATTCACTTAGTCCTATATCTAAAATCTCTTTGTTTTGATCATTTTATTATTACAATATCATTAATTCCTATTATCTCTATTCTTTTAGAGTTGCCTATTATTTCATCTTTTTCTTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTAGTTTTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTAGGGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGAGTTCTTTTCCGTTCTGTGTTTCCACTAACCTTAATCATTAAAACATTCCCCTTTTCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGAGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTTACTTCTGACCTTTCATCTCTTATTATTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTTCCCAAAGTTGTTTTTCCGGATATTACATTAAGTGTTTTTAGTTGTTTGAGAGGTTATGCTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTTATCATATTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTTATGCATCACTATGCTACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACAGAAAAAACCACCTGGGGAGGGTGGTTTGATCGAGAAAAGTTAAGTCAGTCGGGGAACTGCTTAACCAGGTAACTTTGTCTTGTGCGAGACAGGTCACTAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTGTCTCTTATACACATCTCGAGCCCACGAGACCAGAGTGCGCGCGCAGCAATACGTAAC
+
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
@acbeea6e-e8c5-4196-a07d-cb50ad198d62
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGGTCTCGTGGGCTGGAGATGTCATCAGAGACAGGTTAACTCACTGACTGGTGATCGGAGTACTGAAAAGTTATGAAGCTGGGGGCATTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCAGGGACGAGGAGTATGCCGGAGGTGCTGATCGCTATTACGGGTATCACCGTGCCTATTATCCAGACTTATGGCGGGTCTTCCCGGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCACATTCGCTTTCTGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACATCCTTCCTGTTTTCCGGGGTAAAACATCTCTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAACCCGGTGCGGCTGGTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCGTGCGCTGATAATTCTTTTATCTCACTGAAGCAGATCATCGTCAGTATCAATGGTTTTTTGTTCTTCGTGATATGCCTATTCACAGAATCTGATTCCTGTATTACAACTAAGGTAAACTTGAGACTTTTGCTTTCTTTTCATTATTTAAAATTAAATAATCTGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATCTAAACACCTCTTTCTTACACGTGAGCAATGATTTAGATCTTCTATTGCGCCATTCTTGTTTTTTCCTGGCATGATAAAGAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGATGAAATGTTAAGCTCATTTTAATGTTGAGGTATCGATCTTTCCGTGTCAGAAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTTGGTTTGTCTTCCATTTATTTTTCTTTCCAAACATCATTAATTCCTTCCTATTTCAAGTAGATTACCGAGAAGTGAAAATCATCATCCCTCAACACGAAAATGACTTTTTTATAATCATTTATTTTTTTCATTTATTATCTCACCTCCAGCCATTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGAATATACTTCTTTCTTTTTCTCTAATTCATTTATCGCATATTACATGTCATAGCTGCTGTGTTGTTGTAAATATTTGATTAGTATTGGTTTTGCCAGCTATCAAGCGTTGATCCTTATCTTTGATTACTGATAATGAATTCCATTTTCTATACCATCAATGAGAATAGTGAGTCTTTTGAACTAGGATTGAGCTAATGAAGACGGCGCTCTGCTTATACTTCACCAAGCATTTGATATTTCATTTAATTCATAATTCTATATCAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTAGCTATATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTGTGGTAGTAGTTTTGATGCGTTTTTATCGTTGCTTCTTTGTTTATGTGTTTCTTGATGTGGATTTATTATCGCTGCGGTTTTGAATTCATATGGCTTACGCTTTTTTAGTTTGTTTTATTTTACTCCGTTTATTTCTTGTGCTTTTGTTATTTTTATAGTAATCAATTCTTCTGAGTTCTTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCCCTGAGAGCCGAGGTTTGTAATGGAGGGGTGTTTGATAATATTGACTCAACATTGAGGACACATGATTCACTTTGTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCGGCCTTTCATCTCTCTTATTGTTACATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAACTATCCCAAAATGGGTTTTCTTTGTTTAAAGAGATGCTTCATTTCTAAAGCTTTACTTTCCAACAGGCTGCTGGGTTTTTACGTCGCGAAATGAAAATATCGCGTCTAATATCAGTGTTTCCCAAGTTATTTTTCGGATATTACATTAAGTGTTTTTGTAGTTGTTTGAGAGTTATACTCTCAAACGCTAAAATTTTAATTGGATATCTTTTATCATCATTTAAACTTGCTCTCATTTCTGTTTACGTTTACATAGTAATAATAATTTATTGTAAGCCGCTATACCCACTGTTTCTTTCTAGAAGTATAATCAAATATTACTTTATAGTCCTGTTTGGATTGAGTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAAAGCCACACCAGGAGGTGGTTTGATCGAAGGTTAAGTCAGTTGGGGAACTGTAACCAGGTAACTGTCTTATGCGAGACAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTGGGCCATGCTTCAGAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCCAATGGCTGCTGCCAGTGGCGCTTCGTATTGTCTTACCGGGTTGGACTCAGGCGATAGTTACCGGATGGGCGCAGCGGTCGGGGGCTGAACGGGGGTTCGTGCCTGGCGGGCAGGGTGTGACTACGCAGACCAGTTTCTGGCGGTGAGGCTATGAGAAAGCTTGCCTTCCGAAGGAGAAAGCGGACAGGTATCCGATGCAGCGGCAGGGTCAGACAGGAGAGAAGCGCACGAGGGCTTCAGGGGAAACACCTGGTATCTATCGAATCCTGTCAGGTTTCGCCACCTCTGGCTGAGCGTCGATTTTGCTGTTTGCTCGTCAGGGGGCGGAACTATCGGAAAAACGCCCTGCGGCGCTGTTCCTCCGGTGCTTGCTTTTTGCTCACATGTTCTTTCCGACTTTATCCCCGATTCTGTGGATAACGCATCATTACCGCTTTTGAGTGAGCTGACACCGCTCGCCGCAGTCGAACGACCGAGCGTAGCGAGTCAGTGAGCGAGGAAGCGGAAGAGCATATGTGACATTTTCTCCTTACGCTCTACGTTTGTGCCGTTCGGCATCCTGTCCCTGAGCGTTATCTCTCTGTGCTATTTTCGCCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTGTTGCAACCTGCACATGGCAGCTGTTCGTCAGCATCGGGTGCGTCAGTTTTCGAGCAGCGTCAGGCTCCTGACTTTTATGAATCCGCCATGTTGAGTACGGCTTGCTGCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTTATTGTGATTATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGGCGACTCTGTCAGACAACTTGCACTGTCACTGCCAAAAAACTGCCGCGTGCGGCTGTCGGTAATTCAGGCTTGCTGACAGGACAGGATGTCTGGTGTTATACCGCGCATACATGCGCTATTACAATTGCCCTGGTCAGGGCTTTGCCCCGACACCCATGTCAGATAAGACCATGTTTTATATGACAAAACAGAGTGAAGTAATACGCGCAGGCGGGCTGTCAGTCGCCCTGAGCAATGATACATGTGCTT
+
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
@6b203a8d-0b7b-4c3a-82f3-f3d23f369c20
TTGCAGTGTCTGCACTCAGAATATCGCGTTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTTGCGCTTCTATGATTTTGTAGGTGGGGTTGTTTCATATTTTGATATAAATTCTTTTATCTCTTTCCTGAAACAGTCATCGATCGGTATCAATGTGGTTTTGTTCTTCATTGATATACTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAGCTTGAACTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCGAGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCACTCTGCCACGCACATGACAATAGGTTAGATGCTATTGCGCCATTCTTGTTTGCATGATAAAGA
+
7?11)1A::;))'&&.955%$42192:7B723,*,6/0;9;=8@4*<6:996>=27@<:=56,-6A44K?47@CMMG;?56577<=DC4)-:@;;<@3/*%%-%5==@?CEFC61)-';+,.8*0-9=9<>@?F=9686-&&+&%=478;=<<7>7...4$'%%*0&(/+:?60&&&&816@=9BDD56*7:AELI?C)-'8?;;==9-&#$+(,*+)*2,-/&7*::6:/1/3902>B??;989+(0(+$<=?CAC:;?>5./EG=C@FD<:=?57:B3:<:%*(78<<2()*),64<:8:>,<?995/)223;6;;B<DB,<>7FEJB;=@GB:??>=C34171+$(*%$$#()%5%''&''%'+,$$*))"#$%)%&%'$'0%324*%('..%$*'&&.,3611;;6+8.)$%$$$*##$%('/())(%
@68b289ec-48ec-4f90-b773-f43195438516
CGTGCCGCGTTAAGTTACGTGTGCTGCGCGCACTCTGTCTGATCTCGTGGAAGCTGGAGATGTCAATATAAGAGACAGGTATCTTTATAGTCCTGTATCGTGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTTGTGTTTCTCGTCAGGGGGAATGGAGCCTATGGAAAAAACCTTACGGCGCTGGCTTCCTCCGGTGCTTTGCTTTTTGCTCACATGTTCTTCCGACTTTATCCCAGTTCTGTGGATAACCGTATTACGCACGGGTGAGCTGGCCACCGCTCGCGCGGAGTCGAACGACCAGGCGTGTGAGTCAGTGAGCGAGGAAGCGGAAAGAAGCGCCTTGTGACGTTTTCTCCTTACGCTCTATTGTGCCGTTCCGTACTAATACCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCGGCGTGTCTGGATGCTGTTCTGGGTTCTTCTGAGTTCGTGCAGCTTCTCTCACACATGGCAGCCTGTTCGTCAGCATCGGGTGCGTCCAGTTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCGCCATGTTGAGTACGACACCGCCTTCATTATCTTTCGTTTTCTCCGTTCTGTCTATCATCTGCGTTTATTGATTATATCGCAGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGAGCAAATTTCTGTCAGACAACACTGTCACTGCCCAAAAAAGCTGCCGTGCCTTTGGCCCGATGTTGATAATTCAGGCTTGCTGACGCAAGGGACGGGATCATGCAATTATGCCGCGCATACATGCACGCTCTTACCAATTGCCCTGAACTTTGCCCCGACACCCATGTCGATACGCAGAGCCATGTTTTATGACAAAACGAAGTGCGGAAGTAGCATGCCACCGCGCAGGCGCGACAATGATCCATACCTGTTCGTCTGACAGCAGAAGAAGACCAGGAAATCGAAAAGGGCGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTACGGGCTGGCAGCTCTCGATAAGAAGAAAGTTAACTCTCACTGACTGATGATCAGGTACTGAAAGAGTTATGAGACTGGGGGCGTTACAGAAAAACTCTTTATCTATCTAGGCCTTGAAGCGTGTCGGGGACAGAGGAGTATGCAGATTGCTGATCGCACGCTTCTAATAAGGATATCCTACCCAATGCCTATTTATCCAGAGAAGCTTATGGCGGGTTGGCGGAGAAAGCTGTTAAACAGACGTTATGAACGCGTAACTCCCAAAGTGGTGATCACCATTCGCGCTCTGCATGCATAGCTAGCCACGGCAGGCTCAGAAAACGATCCGGCGCATCCTTCCCCTTGTTTCCCGGGGTAAAACAGCATCTCTTTGCGGTGTCTGCGTCAGAGTCGCGTTCAGCGCGTTCAGCGGTGCACTTTGAATTACGGCGTATGTTCAAATTTTATAATTTATGTTTGCCGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCGCCTTTTGTTATAAATTCTTTTATCTCTTTCAGGCAGTCATCGTCAGTATCAATGGTTTTGTTATTCTTTGATGCCTATTCTGAAATCCTGATTCCTTATTACAACTAAAAATTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGAGTAGCGTAATCAGGGATCTGAGATGTAATAATATAGATTCTTGTTCTTTTATTTTATTGAACAGTCGTCTATATATCTAAACACCTCTTTTTCTTACACGCGTGAGCAATAGTTGAATATCTTCTATTGCTGCGCCATTCTTGTTTTTCCTGGCATGATAAAGAAAGATGTTTTTGTAGCTAGATTAATGGCTATAATATTCATTATGCGAGGCTTGGTGATCAAATGTTAAGCTCATTCAATGTTGAAGTATCGATCTTTCCGTGTCAAAGCGTTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTGTTAAAAGACTCTATCTTTAAATGCTCTAAGGGTTTGTTTTAGTTTTGTCTTTTCGTTTGTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAGGAAATTATGAAAATCATCATCACCTCCCAACTTAGAAAATGACTTTTTACAATCATTTTATTTTCTCGGTTTCATTTATCTCACACTCCCAGCCATTTTCAACTGAAAAAGAAAAAATCATATGTGCAGGAATTGCATTGCTGTAGGTTTTTGGAGATTCTTGTCTCTTCCCAGTCTTGCTTAGCAGATATATCTTTTCTTTTTTCATCTGGTCGTTTATCGCACATATTGCATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTGCTGCTTCTATAGAAGCGTTGATCATATCTTTGATTGGAAGTAATGGTCATTTTCTATCATCAATGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATGTTTCGATTTAATTCACTTGGTCCTATATCCAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTGGCTGTGATATCGTTCAGTTCTATTATTCATTTTTTTAGGTTGCCTATTGTCATCTTTTCTTTTTGTGTTAGTAGGGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTGAATTCTATAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTTATTTCTTGTGTATTTTTGTGTTACTTTTATAGTAATCAGATTCTTCACAGAGTTCTTTTTCCGTTCTGTGTTTTTCACTAACGCACTTAATCATTAAAACATTCCCCTTTTCCTGAGAGCCGAGGGTTCGTCGCAATGGAGGAGTGTTTGATAATATTGACTCAACATTGAGGACACGCTTGATTCACTTTGTGTGTGTTATCTATCGTTGGTGATATTTTTGTGTTACTTCTATAATCTCTTATTGTTATGGACATTTCTTTTGGATGTGTCCGTAATGTTATAAAATAGCTATCCCAAAATGAGTTTCTTTATTTAAAAGAGATGCTTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATGGTGTTTCCCAAAGTTGTTTTTTCCAGATACCATTAAATTGTTTTAGTTGTTTGAGGTTATGCTCTCAGAAACCGCCAAATTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTATTTAGCCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATGTTACTTTTTGGTCTGTTTAGTTGATTTTAACAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCAGATGCAGCTAATCTACAAACTTAGAAAACGAAAAAGAAACACCTGGGGAGGGTGGTTTGATCGAAAAGATTGAGTCAGTTGGGGAACTAACAGCAGGTAACTGTCTGCTTGTGCGAGACAGGTCACCAAAACTGTCCTTTCAGTGTAGCTGTGATCAGGCCATCACTTCAAGTACTCTCGCCAGGCCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTTTGTCGTGTCTTACCGGGTTGGACTCAAGACTTGATAGTTACCGGATAAGAGCGCAGCGGTCAGGGGCTGAACAGGGGGTTCGTGCACAACCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCTGGCGTGTGAGCTATGAAAGCGCCACGCTTCCAGAGAGGAGAAAGGCGGACGGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAAACGCACGGGGGGCTTCCAGTACCTGGTGTATCTTTACACCATAGTCCTGTCGGGTTTCGCCACCTCTGGCAGGCGTCGATTTTTGTGATGCTCGTCAGGGGGCGGAGCCTAGTGAAAAAAAACGCCACCAGCACCTGGCTTCCTCGGTGCTTTGCTTTTTTTGCTCACATGTTCTTTTTTCCAGGCTTTATCCCCGATTCTGTATGGATAACCGTATTACCGCTTTTGAGTGAGCTTGACACCGCTCGCCGCAGTCCGAACGACCGAGCGTAGCGAGTCAGTGAGAAGCGAGGAAGCGGAAGAAGCGCCTTATGTGACATTTTCTCACTTACGCTCCATTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTAATGCTGTCATCTCTTATACACATCTGACGCTGCCATTTCGACGACAGAGAGTGCGCGCGCAGCAGTACTATTAAC
+
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
@7a97d860-e33a-4e27-b5be-c4754a2eb907
GTTGGCCGCCCCACGTTCAGTTGCACGTATTGCTGCGCGCGCACTCTCTGGTCTCGTGGGCTCAGGATGTGTATAAGAGACAGATTACGAAGTATCACGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCAAAGTGATCACCATTCGCTTTCATGCGCCTTGGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGAAGGGTAAAACATCTCTTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGAATGCGATACAATTACAGCGATATGTTAAATTTTATAATTGTCTTTAGTCATTTTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATGTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATACCTATTCTAAATCTGATTCCTTATTACAACTAAGGTAAACTGAACTTTTGCTTTCTTTTTCATTATTTGGGTAAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAAGATCTTCTATTGCGCCATTCTTGTTTTCCTGGCATGATAAAGAAAGATGTTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGCGATGATTAAGAATATACTTTCTTTTTCATTAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTAGTTTGTCTTTCCATTTATTTTTCAACACAAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTTATAATCATTTATTATTTTCTCAGTCTCATTTATCTCACCTCCCAGCATTTTCAACTGAAAAGAAAAATCATCCCATATTCTAGAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATGTATCTTTTCTTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGCTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCATTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTACTTAGTCTATATCTAAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTACCTATTATTTCATCTTTTCTTTTTTGTGTTAGTAGTTTGGTTGTTTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTGGATTCATATATAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTCCGTTCTATTGCTTCACTAACCTTAATCATTCGCGGCTCCTTCGCACTGCGCAAGAGCCGAGGGTTTGTCACGCAATGGAGGGTGTTTGATAATATTGACTCAACGTTGGGGACACGCTTGATTCATACGTTATCTATCCGTTGAGTATTTTGTGTTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATCGCCATTTCTAAAGCTTTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTCAGATATTACATTAAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTCAGAAACACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCCTTTATGCACTGTTTCTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGCTTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAAACCACCTGGGAGGTGGTTTGATCGAAGGTTAAGTCAGTTGGGGAACTGCTTAACCAGGTAACTGTCTTGTGCGAGACGAGTCACCAAAACTGTCCGCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCATCGACTTTTACCAATGGCTGCTGCCAGTGGCACTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGGTTCATGCACGGCCCAGCTTGGAGCAGACGACCTACACCGAACCGAGATACAGCGTGAGCTATGAAAGCGCCCTTCCGAAGGAAGGCGGACAAGGTGTCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGAGCTTCAGGGGAAACACCTGGTATCTTTATAGTCCTGTCGGGTTCGCGCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCAGGGGGAGCCGGAGCCTATGGAAAAACGCCTGCGGCGCTGTGGCCCTCCGGTGCTTTGCTTTTTGCTCATATTCTTTCCGACTTTATCCCCCGATTCTGTGGACGGATAACGTGACTACCACTTTTGGTGAGCGCATTTTTGCTCGCCGCAGTCGAACGACCAGACCCTGAGACCAGAGTGCGCGCAGCTTGATGCGTAAC
+
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
@3e0d3907-4283-4aee-a52f-4b11a777fab9
CGGTATGCTTCGTCGGTTACGTATTGCTGCGCGCGCACTCTCTCTGGTCTCGTGGGCTCGGGATGTGTATAAGAGACAGGAGGTGCTGATCGCTATTACGGAGTATCCACCGTGCCCTGTTAATCAGACTTATGGCAGATTAGCTTCCCGGAGAAAAGCTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCAGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTGCGGTGCGTCTGCGTCAGAATCGCCCATTCAGCGTATCGTTCAGCGGTGCATTGAATACAGCATTATGTTAAATTTATAATTGATCTTTGATCATTACGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATAATACCTATTCTAGAATCTGATTCCTTATTACAATAAGGTAAACTTGAGCTTTTGCTTTCTTTTCATTATTTGGGTAAGCGCAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTATTTTATTGAATAGATCGTCTATATATCTAAGCACCTCTTTCTTACACGCGTGAGCAATGAAGTTAAGTCTTCTATTGCGCCATTCTTGTTTTTCCTGGCATGATAAAGAAAAGATATTTTGTGCGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTCAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTCTTTTCATTAAAAGACTCTATGTACCAAATGCTCTAAGGGGTTTATTTTAGTTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTACCAAAGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTTCTCGGTTTCATTTATCTCTCACCTCCCAGCCATTTTCAGCTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTGAGATTCTTGTCTCTTCCCAGTCTTATCTTAGATATATCTTTCTTTTTCATCTAATTCGTTTATCGCACATATTACATGTGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATAGATCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCTATATCTTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTGTGCAATATCGTTAATTCTATTATCCTATTCTTTTTAGGTTACCTATTATTTCATCTTTTCTTTTTTTGTGTTAGTAGTTTTATTACGTTTTTTTATCGTTGCTTCACTTTGTTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATACTTAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAACATTCCCCTTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTGAGGACACGCTTGATTCGCTTTGTGTGTTATCCTGTCTCTTATACACATCTCCGAGCCCACGAGACCAGAG
+
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
@605fff70-64ab-4859-b4d2-208400dd0b88
GTTGTACTTCGTTCCAGTTACGTATTGCTGCGCACTCTCTGGTCGTGGGCTCCGGAGTGTGTATAAGAGACAGGCCTTTGTCCGGTAATTCGAGCTTGCTGACAGGACAGGATGTACAATTGTTATACCGCGCGCAATACGCTATTACAATTGCCCTGGTCGGGGCTTTGCCCCGACACCCATGTCGAATGCTGGAGCCATGTTTTGCCAGAGCAAAACGAAGTGGAAGTAATACGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGACGGCGAAGACCAAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTCCGGTTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACGGCTGATGATCGAATTTGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCGGAGGTGCTGATCGCTATTACGGGTATCACCGTGCCCTGTTATCCAGACCTATGGCAGATTAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATGGCTATGCAGCGAGCTGAAAACGATCCTGACACATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTAGAGTTGTTTCATATTTTTTGATATAAATTCTTTTATCTCACTGAAGCGAAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCACTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCGTTATTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAGATCTCTTCTATTCGCCATTCTTGTTTTTCCTGGCATGATAAGAAAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGGTGATGAAATGTTAAGCTCATTTAATGTTGGAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCAGCATCGATGATTAGAATATACTTTCTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTTAGTTTTGTCTTTCCATTGTTTTTCAACATAAACATCATTAATCCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACAGAAAATGACTTTTTTATAATCATTTATTTTTCTCAGTTTCATTTATCTCCTCCCAACTAATTTTCAACTGAAAAAGAAAAATCATCCATGTTAAGTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTATGCTTCTATCAAAGCGTTGATCCTTATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTGAACTTCAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCCTATATCTAAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTGTTTATGTTTCTTGATGTGATTTATTATCGCTGCGGTTTTTGAATTCATATAGCTTACCTTTTTAAGTTTTGTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCTGGGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCCAACATTGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTATTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAGAAGAGATGCTTCATTTCTAAAGCTTTTTACTTTTAACAGAGCTGCTGGGTTTTACGTCCTTAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTCAATTTTCCGGATATTACATTAAGTTTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACATAAAATTTTAAGTGGATATCTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTCTATTTATGCATCACTATGCCACTGTTTCTTTTCACAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGAGTTCTGGTCGTAATCTCCTAAACTGAAAACAGAAAAAACCACCTGGGGAGAGGTGGTTTGATCCAGAAAAGGTTAAGTCAGTTGGGGAACTGCTTAGCAGGTAACTGTCTTGGTGCGGGCAAGGTCACCAAACTGTCCTTTCAGTGTAGCTGTAGTCGACCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTACCAATGGCTGCTGCCAGGTGGCGCTTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGCTGTCTCTTATACACATCTCCGAGCCACGAGACCAA
+
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
@6e5531a0-6e40-43d8-87b8-3a7c8acbd3d8
GTTGTACTTCGTTCGGTTACGTATTGCTGTACAGTCGAAGGTTAAAGTCAGTTGGGGAACTACTTAACCAGGTAACTGTCTTGTGCGAGACGAGTCACCAAAACTATTATCCTTTCAGTGTAGCTGTAGTCCAGGCCATCACTTCAAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTGCGGATAAGGCGCAGCGGTCGGGCTCGAACGGGGGAGTTCGATACACACAGCGCCAGCTTGGAGCGACGAACGACCTACACCGAACCGAGATACCTACAGCGTGAGCTATCGAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAAGGTATCCAGGTAAAGCGGCGAGGTCAGGAACAGGAGAGCGCACGGGGAGCTTCAGGAAACCTGGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTTTGTGATGCTCGTCAGGGCGGAGCCTATGGAAAAAACGCCTGCGGCGCTGGCTTCCCTCCGGTGCTTTGCTTTTTGCTCATGTTCTTTCCGACTTTATCCCCAGGATTCTGTGGATAACCGTATTACCGCTTTTAATTGAGCTGACACCGCTCGCCGCAGTCCAGACGACGAGCGTAGCCCAGTCAGTGAAGCGAGGAAGCGGAAGAGCGCAACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCTGAGCGTTATCTCTGCTATTTTCTACTTCAAAGCGTGTCTATGATTGCTGTTCTGGAGTTCTTCGCGAGTTCGTGCACGGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCAGGTGCATCCCAGTTTTCGAGCAGCGTCAGGCTCCTGACTTTTTATGAATCCGCCATTGTTAATTACGGCTTGCTGCTGCTTGTTCATCTTTCGTTTTCTCCGTTCTATCTGTCATCTGCGTTTGTGTGATTATATCGCATACCCGCTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGAAGCGCGGCGGGCATTTCTGTCGAACAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGGCCTGGTGTTATACCGCGCATACATGCGCTATTACAATTGCCCTGGTCAGAACTTTGCCCCGACACCCATGTCAGATACAGAGCCATGTTTATGACAAAACTGAAATTGATAATACGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGACGGCGAAGAAGACCAGGAAATCAGAAAAGGGCTGCTAGATGCAGCAAGACCGTTTCCGGTTTTTACGGGCGGCAGCTCTCGATAAAAGGTCACTCACTGACTGATGATCGGAGTACTGAAGAAGTTATGAGACTGGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCAGGGACAGGAGTATGCGGAGGTGCTGATCGCTATTGCGAATTATCCACCGTGCCTGTTATCCAGACTTATGGCAGATTAGCTTCGAGGAGAGAAAACTGTGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGTAAAACATCTCTTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGTGTTTCAATAAATTTTTGATACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTTGATATTGCGCTATGATTGTAGGTGGAGTTGTTTCATATTTTTGATACAATTAACATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCGGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGAGTTAGATCTTCTATTGCGCCATTCTTGTTTTCCTGGCATGATAAAGAAAGATATTTTGTGCTTCCGTTAGCGGCTATTTCATTGCGAGCTTGGTGATGAAATGTTAAAGCTCATTTAATGTTGAAATTATCGGTGCTTTCCGTGTCGAAAACGATTCCGTCGGCGCATCGATGATTAAAATATACTTTCTTTTTCATTAAAGACTCTATTCTTTTAAATGCTCTAGGGTTTGTTTTAGTTTTTGTCTTTCCATTTATTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCCTCACCCTCAACGAAAATGACTTTTTTATAATCATTTATTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTCAACTGAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCGCATATTACATCATGGCTGTGTGTTGTTGCTTAAATATTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCCTTATCTTTGATTAGGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTGGAGCTACAGATTGAGCTAATGAAAGACAGTAACTCTGCTTACTCCCTTCTGCTTGTTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTACAATATCGTTAATTCTATTATCTATTCTTTTTAAGGTTGCCTATTATTCATCTTTTCTTTTTGTGTTAGTAGGTTTTGATGCGGTTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCACTGGGTTTTTGAATTCATATAACACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTATTGTTATTTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTTCCGTTCATGTTTCACTAACCTTAATCATTAAAACACTCCCCTTTTCCTGAAGCCGAGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGAGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTATTACTTCTGACCTTTCATCCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAGAGCGCGCGCAGCAATACGTAACTT
+
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
@ec42881a-d0a8-43da-b663-d584d9451c8a
GTTGTACTTCGTTCAGTTACGTATTCTGCGCGCGCACTCTCTGGTCTCGTGGGCTCGGAGATGTACAGGAGACAGCTCACACATGGCAACCTGTTCGTCAGCATCAGGTGCGTCCAGTTTTCGAGCAACGTCAGAACTCTGACTTTTTGAATCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTCGTTTTCTCCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCATTACCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAGGGCTTTGCCCGACACCCATGTCAGATACGGAGCCATGTTTTGTGACAAAACGAAGTGCATAGATGGTACGCGCAGGCGGGCTATCAGTCACGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCCAGAAAAGGACTGCTGAATGCGGCAAGACCGTTTCAGTTTTTTACGGGCAGCGGCTCTCGGTAAGAAAAGTTAACTCACTGACTGATGATCGGGTACTGAAGAGAGTTATGAGACTGGGGGCGTTACAGAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGGAGTATGCAGGAGGTGCTGATCCGCTATTACAGGTATCCACCCGTGCCTGTTACCTCAGACTTATAGCGGATTAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCGGGTAAAACATCTTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGCGTTTCAGCGGTGCGATACAATTAACACAGCATTATGTTAAATTTTATAATTGTCTTTAGTGTTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTTCATTATTTGGGTAAGCGTAATCAGGATTACAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAGATCTTCTATTGCGCCATTCTTGTTTTCCTGGCATGATAAAGAAAGATATTTCTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGAGTTTGTTTTAGTTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTTATAATCATTTTATTTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTCAACTGAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTGAGATTCCTTGTCTCTTCCCAGTCTTGTAAGATATATCTTTCTTTTTCATCTAATTCGTTTATCGCACATATTACAGCATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTTGCTACTTCTATCAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCATCAATGAGAATAATTGAGTCTTTTTGAACTAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTTAATTCACTTAATTCCTATATCCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTGTGTTAGTAGTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTTATTTCTCGATTTATTTCTTGTGCTTTTTTGTTATTTTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCCTTTTCCTGAGAGCCGAGGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAGCTTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAGTAAATATCGCGTCCTATCGATGTTTTCCCAAAGTTATTTTTTTCCGGATATTACATTAAGTGTTTTTAGTTGTTTTGAGAGATTATGCTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACATACCACTGTTTCTTTTCGATATAATCAAAATAATATTACTTTATAGTCCTGTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAAACCACCTGGGTGGTTTGATCGAAGGTTAAGTCAGTAAGAACTGCTTAACCAGGTAACTATCCTTGTGCGAGACGAGTCACCAAAACTGTGTCGCTTTCAGTGTAGCTGTAGTCAAATACATCCGCTGAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACAGAGTTGGACTCAAGACGGTAGTTACCGGATAAGGCGCAGCGGTCGATGAACAGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCTACAGCGTGAGCTATGAAAGCGCCCTTTTGAGGAGAAAAAGGCGGACAGGTATCATTAGCTGTACTTGGGGTCGGACAGGAGGCGCACGAGGAGCTTCCGGAAACGCCTGAGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGATGGATTTTGTGATGCTCGCCAGAGGCGGAGCCTATGGAAAAACGCCTGCAGCGCTGGCTCCGGTGCTTTGCTTTTTTGCTCACATGTTCTTTCCGACTTTATCCCCGATTCTGTGGATAACCCATTATTACCGCTTTTTGAGTGAGCTGACACCGCTCGCCGCGGTCGAACGACCAGGCGTAGCGAGTCGGTGAGCGAGGAAGCGGAAGAGCGCCATATGTGACAGTATTTTACTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATCTGTCTCTTATACATCTCCGAGCCGGACGAGTGCGCGCGCAGCAGTACGTAACT
+
$**$$$78;<7L@1-;<;3/),***%*<?E?I?A@8<</6;.80(5/>9F8>HC+A393BA=0.(($1&&)'+(':5=4)3A9>57;+,;:<A47601A>9+5,.&;7DD@<&&:0@DEG=)$2<:++-&('%'%%$&/5?@CIGLG<77=;;<9;<E?D25?7BA=@:;?HGA<>4/4:8:=:EEEEAFIGEF=LEIB>@*3*)29>>72;0.<B@>@92;9C@132)-&>7(7>@EEDAACDGA?DFOMFBHHKHLLT:33B==?<KGB@55<>3;88CD4=;<>FFB??A@;GEDCLA?64/4&&6<67<<=>/*C**??AALHJLLIAC@>.&&+&&&%*A4-A%.AFIOF=;;H@EI>CAJF2+AD8659ACE.?(8)+)/@/=97:<;>;;BKD>AE<8:80:5/)((*,;786>+>>90+,0,(1;:=DDE>=:51118A@;EA:0808A97=8;99EC.(=HGJ?%9CHHJKJD@761.7(#'1357A-1(>>@9?/%46G(-79:,$=4425$5:A>=B>BD8//92H@101)'%'&$1-=@A1&95.4G&&::2@4/-(B:9:=8AFCD=:>34=>@FGCD<JI/4,<GGVOIB,>%*,'%01$-B@85C.7B89=A>;9==?CF>GAC84?D@@=<;;4.(*/3>5/-//0&3(217>55968>;9/2>9@A?IC>7:4/A9A7A?8GGGCBB?=B;B@:347:D92E+2>C@4,=7325>@00,*86'38B68476-.;332++/2'$,.39441/>?82<3205)+.'%#((#($$%%1,&-4#&&,.)-/;=1>J?A@<3%1394-956B?@ABE@9<FG<DDE>643'.)(*5=?=@@5:9EEF@JCA>B@A=BD;=6..8GCAACI9<0FEEC53@:EDA<:9;:9;FBBCD:;=9=<;-43,,44=&:@=B?A@17302178A@<3780.;;A9G6=B:16=C?85DBC?D?FDJCJDG?>3*(,3.=@@>9;4;=C>A88EHB@@9=+/'-*.&4017B>>BA>B@HJJHHG3JDNE=>GF4-,%&;<3<=@IHBCDBHNI1:9<8BGB;;:=?=@I>:?>AEDCCA>E>DHJDC@9HHJH@9A:@EEC<<818889?GF?8;@24H85D=>09;JGMKBHE@HHC8:<65?B;=A@C>==3,&&44)B,B@EF*.5;668>@+,7?9:.8:8:,222.-2=BAEA746C@8=CF>A9AB:1==B9=CDAD>EFE>0&8.88315))235<;*)776-4:;B8@EDDEGCC@;CCGGADDSN<LFD<B<88CB@=<@AAB@+=79;GIBB<>BF;BAI;<??;;:75/;>>FB?4+*,@/:%6,;GD@@=CF>FGEEBA><8F@AASI>AC>@A=EA<533(.:82+B<6LL<FC7//5GF<>7HHGJM@BGE?IJJE@?ED776--7DDD>BA?B@EEJK89DC<=?BED:HLGCF>BEA@AIHBC@<CAE<<GCB6:<F9403,33@<5''9:;99;#&;?:<;?DDDFC?@;9A@@<<=CDD=JFVGJA:E>BB0'4@@C>?B34:AHLFIML<2)@A:22-$5;@?5FDIC;?;=AF8875;8*+49>E?EBDC.;=>=@<CE@;B?B9IJFGHE9:GDDGC@A>>=965-9)).'(78,6723&78:A>83*)-13<CCEHEAE;<7/0AAHGDEDMK\H@FGGD=7BBACKG=IDJED<=<%-CCBB@ACB=8:6>9755+4-6+./5:?;>--1144A-*A7?EGD??>BC?7:HF.0++8798::'456@=@AIGLH>@B@HD:;@F?:<A@B?.1.+799?=%&%)BAC?*645:=KEFBG@?B:5?6?@;A75>??A=?:=;=A9A677:634C=@=E;=;@50BA=JJ7NO@D=@B<<GEGGCRB9;=2;=,/1=OHEF<>5-''*A>@8778(,.79=6-A-B>;>BHIGFND>BHDDEC>@3++48D;>BFFLA;)'0+84E<=9<8@7IA5735?.=18?@ECEFIL@/@&BF@ABEE>ACBFB<*+B<8962BC:;669:7$*8;CCB:6>>?3E?=@EFJGIFCC@EENG==>20$##$-.-4&4<BFE&&(2>NNHIEF;=D?EBE>9<MFEC??A-;=@FBBA>48:?BEGGF>A>OIIIB;+;13=>:=>?<?AHBIGBA?B@@?CCKB<7)<=>7=;;GDNI<RKSJ>B@>:?4539HG=><CCA3D@VKCA@;:FC98;<@ED>*>CGBBFGG@CIHC:3.7'*+//-05197:CAB=@>?LB?67AACAHGDKBHQLE?@CDXMA;?GE81:?FEC:DC4.**$$+:7:4:FEE>,:.9>C>=:7&).4IIUQHD@D@ABFHAE@@<@>JAC>13898>>=9937735-DA;=:B;B@:0=@<EFB:=>EH?ADEDBCG<CFEFAA;>;<?AC9:5D>:3,7776@BD>NQI@?D,;44>8>,=4<E@?@ED@A:?C@DE>A>>@<;?:<8/16=E?H?<((<@?@GA=557@-6.//17A<BA?6.=I:81DHFFGTIC96<89>;<9=7CA?::>CB==@A<@=334*B90..2LAAEHL@JFB=?=?94:8:@CCF057100.*11=3>@?<@EEFGHG@F@HHHSIAMFF>FBA34/--+(GC>DE>979:<2:@<ACIIID;9;<<ABDEAE>D?=<-+1<>E@ARJC<:31A0;=?2,//3;>><?143((.;93==@<<77LH<==DD@A>7-=AJE>B>),8;BFCJD=;AJH<=,@;=?PID>?BC;E@F/4$5$7%79@DDCH77855>75)'')46==;=JG;84.DACCFC>@LJUF>;?788HFC;>?DGG:8:>01'.2A197A>F?DDDECBA.99=:@C;9<?;7>9<<7;?B=22/*&3%%&$%33443.145.*.03&$&('&18;9CDF@89A==8879CDEE=;C88;98BB;=;BFA>FG<:;<@?@;BD7.:;.3-89:=9:<997,/..?8134/0&;523+-4565=>56+,-823(%(130346./IKCFE@9;677).*<;?EED@;3><;<4917<*36,%.'%'3.45C956666>/$396&&%()))/*,%1+,3(7;'/%>9<6*>==@;4+%%*''$#$);630107=><A@<:4-4')%$#(4**/%%&#&&'8336.247777>>=E:?D?@BBDDE>B;>KJC>>?@?>/0+-1298CA=6::@@10JJK?9=6(6=>A8)99:-A=<69AABC79?95%%3.;>B?:B>AAAFG2<;CDAFBFA988,:77@2.>;:;BF<2-<9@<<1@:?>A:7?6667:4,+*)47>>?85/6&*4&%*.:18<CGBKJJD95F@<740;;3,,0)('35020''))((&+)*('(16*5+79>>1)**1(+3*)**)%''''$$%$((-**$&+(&>2.*192;83*)<7)9=D>%-&,$&-/$1113*8=>;=??B;;:B>?@B<5C13CBDJF??@<889>769&&-.-.-%%'$-(07B>+8<=KFEHC991)1%%+,$(#(,)9736:<@037;6>=@5*$,+++'#$$#*:..;77;=D4578AIGEACBB>A>;=A?6122)2/::;<:?78871=BDBA?:2;?=970)))&&)++-6@B)(IHFB=;9<:;8G?9@4778:?D@;2$0*6&./)))/?AFJ<%%460320/'%64?%))$%,/22&002-2;<==-<+;(()$,3*),.-*$$*%021-&)6,3,-%48@:A>?AF8AACE9J9A>CA>22:<50038237>AEBA=A3+79F>C?=><>ANID8>>EC?JIB?>8A<9?;=ADC@?FEB;@:,/(=HG?E=840//--86-(++,,2:=<9-)&,6;.*;177@AB=@7353);>A386-89*$((+%&,@76,%(%#**,*$&((;7753&'
@2553ffaa-728f-411b-9ec6-79d07c5bfd70
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTGTCGTCAGCGGCGTCAGATGTCGTATAAGAGACAGGACGCATCCTTTTTCCCGAGGTAAACATCTCTTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCCGTTTCAGCGGTGCATTACAATTACATAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTATCTCACTGGAAGCAGTCATCGTCAGTATCAATGGTTTTGCAATTTCTTCATTGATATACCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGTGTATAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATGTATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAGATCTTCTATTGCGCCATTCTTGTTTTCCTGGCATGATAAAGAAAAGATATTTTTGTATTACTTCCGTTAATGGCTATTTCATTGCCGAGCTTGGTGATAAATGTTAAGCTCATTTAATATCGATCTTTCCGTGTCGAAAAACAAAGAATAACAATAGAAAGATCAATGTACTCGTGTGAAAGAGACATTTAATATATGAACGATCTGTTCGATAAATAATAGTGAATCTGTTTGGCAAGCAAAATGAGCATATCGGTGAATCATCTCCATAGCATAAAATTTAACATAATGCTGTGGTGTACGCACCGCTGAACGCCTTTGAACCTCACAAACGCGAACTTCCTGATGTTTTTGCAAGAAGGAAGGATGCGTCAGGATTTTCAGCTCGCTGCATAGCTATGCATGAAGAAGCGAATGGTGATCACTTT
+
*((''((--./0*-&5?=2==8636932*-%$&%''.25**(:?2/.$:<$.A2.>59520&&$59>-./+,**+0@A@0+B33<711122:'-$+3756<@?=CB?FEKCC=1*?@>:;..A,&E=A:@<B,?<C:1@,8,$355A..),5)-=.3$$)0<898/%&%"%,,'&(;<>B@@A@RML?9DCE4NB>@QMF.1=?<?F=)>=FF<=;?JYNB;89?C?@:;=A:ACJE-'';611/-*%'&*-..4.6446<<>)<56645872+%/6?C<;545-8951:++0(.@@J?'/'(&3</:15155ABA=77DCB9=<=>;;3:3-6?AIA67</$$';:/(*.236AGBEC9:::7@>@AFA55@C?458ICC@F@5=>:&(,$#%19:5=6;;E;;;:<4;E>9;6<@AB9@596;;DE:AB=GDGA:@AIA:=;@0;:6:72;8:=.0*****'/1229:578?FC;2436)0,'345//?833846CB44@;=C?>4,18@A>;;@IGFPJ>@?OH+,0))1&)&&8=><'((('27::>:98.(%%%&&/0467'+434?6;?=8=@=8$$&$$)78<@@?,/2&&)(*3+,@A>@;??42762**58:<:@44@@?$)/F73+%$$$$#&##$%%-(&&$(('($''%%),+('$&('')($*#%$&&%%%&'&$$(($'**(1,*%%*%)260$13('(*')&.'('+-,$%''5)-,-,&')()$)'(*(,$$.856/+-#$#%##$$&#$%#&%$#$%$'#%$+,01+*)%$$&%$$-($#$+$$&./3,9;11/%%$$&$&#$&+),&*+'&'''(&$'%%&"%&(/$$'*++,-,)#(%&&&&&0*,(%+%%++*)(-3&'*6-1-0<;=43>?=20,8=:@8;?755.-%)%'%'&.2*,550**$$%**
@1195f795-0d1a-4d0c-8024-bd9aae7aa4d0
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAAGAGACAGTTATGAGACTGGGGCGTTACAGAAAAACTCTTTATCGACAGCAAGCGTGTCGGGGACAGGAGTATGCGGAAGTGCTTACAGTCGCTGTGCGGAGTATCACCGTGCCCTGTTATCAGACTTAGCAGATTAAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGAGCTGAAAACGATCCTGACGCATCCTTCACCTGTTTTCCCGAGGTAAAACATCTCTTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTACGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATACCTATTCTAGAATCTGATTCACTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTCGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCTATATATCTAAACACCTCTTTCTTACGCGTGAGCAATAGTTGATCTTCTATTGCGCCATTCTTGTTTTTCCTGGCACTTGATAAAGAAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCCCTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTCAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGGTCGTCAACATCGATGATTAAGAATATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTAGTTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAATTAGAAATCATCATCACCCTCAACGAAAATGACTTTTTATATCATTTATTTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTGGGTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTCTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTTGTCGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCGCTATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCATGAGAATAATTGGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCATTGTTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGAAGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCTTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTGAGGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCGGTTTTTTACGTCATAAAATGAAAATGTCGCGTCTAATATCGATGTTTTCCCAAAGTTATTTTCCGGATATTACATTAAGTGTTTTGGTTGTTTGAGAGTTGTATATAAACATAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTTACGTTTTACATAGTAATAATGTGTTTATTTGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGCTTAATCTCTAAACTGAAAACGAAAAAAAACCACCTGGGAGGGTGGTTTGATCGAAGAGTTAAGTCAGTTGGGGAACTGCTTAACCAATTGTAACTTTGTCTTGTGCAGAGACGGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTGGTGAATACATCTTCATTGCTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATGGTTACCGGATAAGGCGCAGCGGGGTCGGAGCTGAACAGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAGAGGAAGAAGGCGGACAGGTATCCGGTAAGCGGCAAGTCGGAACAGGAGAGCTGCTGAGGAGCTTCCGGAAACACCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACTCTGGCTTGAGCGTCGATTTTGTGATTGCTCGTCAAGGGGCCGGAGCCTATGGAAAAACGCCTGCGGCGCTGGCTTCCTCCGGTGCTTTGCTTTTGCTCACATGTTCTTTCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGAGTGAGCTGACACCGCTCGCCGAGTCAGACGACCGAGCGTAGCGAGTCAGGTGAGCGAGGAAGCCCGGAAGAAACACTGCTGTGACATTTTCTCCTTGCGCTCTGTTGTGCCGTTCGGCATCCTGTCCTAAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACATGGCAACCTGTTCGTCAGCATCGGGTGCGTCCAGTTTTTCGAAACAGCGTCAGGCCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAGTGCGCGCGCAGCAATGCGTAAC
+
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
@eeef3ccf-2188-4382-8399-a9442bbbf40a
CGCTTCGTTCCGGTTACGTATTGCTGCGCGCGCCTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAGACAGGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTTGCAGTGTCTGCGTCAAAATCGTTAGCGTTTCAACCCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACTGAGCTTGATCATCGACAGTATCAATGGTTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCGCTTCCTCTTTCTTACACGCGTGAGCAATGATTAGATCTTCTATTGCGCCATTCTTGTTTTTCCTGGCATGATAAAGAAAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCAGTAATAAAGGAAACGATTAAATAAGCATCAGATAAATAAAAAATATATATCATATTTAAGAGACTATTATTCTTTTTCAAATATAGTTGTTTGGTTTTGTGCTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTGTTTTCTCAGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCGCATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGGTACTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAACATTGATATTTCATTTGAATTCATGATCCTATATCTAAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGATTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTTAGTTTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTGTTATTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACGTAATCATTAAAAACATTCCCCTTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTTATTGAGGACACGCTTGAGGATTCACTTTTATTGTGTTATCTATCGTTGAGTATTTTTGTGACACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAACTTTTACTTTTAACAGAGCTGCTGGGTTTTACGTCATAAAATGAAAATGTCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTTCCGGATATTACATTAAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTCTTTTGTTTCCTCCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGCTGATTATTGTGTTCTGGTCGTAATCTCTAAACTGAAAACGAAAAAACCACCTGGGGAGGGTGGTTTGATCGAAGTTAAGTCAGTTGGAGAACTGTAACCAGGTAACTGTCTTGTGCCAGGACGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCGCTAAGTACTCTCTTGAACCTCTCACGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAGAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGGTTCGTGCACAGCCCAGCTTAAGAGCGAACGACCTACACCGAACCGAGATACCTACAGCGTGAGCTATGAAGCGCCACGCTTCCCGAAGGAGAAAGGCGGACGGGTATCCGGTAAGCGGCGCAGGGTCGGAACAGGAGAGCGCACCAGGGGAGCTTCCGGAAACACCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGAAACTTGAGCGTCGATTTTGTGATGCTCGTCAGGGGGCGGAGCCTATGGAAAAACGCCTGCGGCGCTGGCTTCCTCCGGTGCTTTGCTTTTTGCTCACGTATTTCTTTCCGACTTTATCCCCCGATTCTTCAGCGGATAACCGTATTACCGCTTTTGAGTGAGCTGACTTGCCGCTCGCCGCAGTCAGACGACCGAGCGTAGCGAGTCAGTGAGCGAGGGAAGCGGAAGAGAGCGCCTTATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTATTATATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCCACACATGGCAGCCTGTTCGTCAGCGCATCGGGTGCGTCAGTTTTCGAGCAGCGTCAGGCTCCTGACTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGGCATTTCTGTCGAACAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCAGATTGTTATACCGCGCATACACATGCGCTATTACAATTGCCCTGGTCAAGAGGCTTTGCCCCGACACCCATGTCAGATACGGAGCCATGTTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCAGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGACCAGGAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGAACTAGGGGAGTATGCGGAGGTGCTGATCGCTATTACGGAGTATCACCGATACCCTGTTATCCAGACTTATAGCAGATTAGCTTCCCGGAGAAAACTGTCCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAAACAGTCTGACGCATCCTTCCTGTTTTCCCGGGGTAACTCTCTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAACGGTGCGTACAATTACAGCATTATATTTAAATTTATAATTGTCTTTAGTCATTTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTGCGGTACTTTGATTCTTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATCTGTCTCTTATACACATCTGACACAACGACGACAGAGAGTGCGCGCGCAACAATACGTAAC
+
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
@6921cb1c-c6a1-4519-80c9-abcc28f07698
TTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAATGATACGTACAATTGCAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTTTATATTTTGATATAAATCTTTTATCTCACCAAGCGAGGTCATCAGTGATAACATCCAATGGCTTTGTCTATTCAATGATAACTGCACGTCTAGATCTGATTACCATTACGGCTCAGATCATTTGAGACTTTCTTTTCGTATTTGGTCAGCTAATGAAAATCAGTCAAGGGATTAACAATCAATAGTTCACATTTCTTTTGTTTTATTTGAATTGGTCATCTATATCTAACACCTCTTTTTCTTAC
+
?D-='1?A<=C@>843-/00;@CFFOF>5E?63/9<<8#%%(%''97=@:01.3)''%4%%'==>B>..<AHME;*;<;>@>@58:,-:=:=C:4;<C:=A@CDDC676=7546./.5.4697&%,,./1143+(*(++'**+.,*,.)(##$&(,*+)'(%%'&%%'&''%&')%$$,,-,+*$#%+&+,'$$'/$%'*$$#%"&%('&%%&%$%+)0%+(('&*)&(*#%#&#$%%&%%%+$%%-(($#(+)('*,.$"&$()%$'''($$%$%'&('**)($%(*$%(*)%$*#$$&(&*))&&'$**$%#'*'&&+,,%%%'%&**%&&)%*$'**$(((&'('*%%&%&()./&(+.-&###$
@7b113920-4603-4bc7-8878-f4531f92549c
CGGTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGGAGACAGCTATTACGAATATCACCGTGCCCTGTTATCCAGACTTGCCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACAGACGGGTATGAACACCGTAAGCTCCCAAAGTGATCACCGTTCGCTTTTCATGCATGGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTCCCGGAGTAAAACATCTCTTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCCGTACAATTACAGCAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTTGCGCTATGATTTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTTGCTTTCTTTTCATTGTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATCTAAACACCTCTTTCTTACACGCATGAGCAATGATTTAGATCTTCTATTGCGCCATTCTTGTTTTCCTGGCATGATAAAGAAAGATGTTTTTGTGCTTCCGTTAATGGCTATTTCATTATACGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACAATTCGTCAGCATCGATGATTAAGAATATACTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTGTTTTAGTTTGTCTTTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTGGTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTTATAATCATTTATTTTCTCAGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTCCTTTTTTTCATCTAATTCGTTTATCGCACATATTCCCACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGGTAGTGAATTCCATTTCTATGTCGTAGGAATAATTGGAGTCTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTTGATCTGTTGCTATTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTTTTTTGTATTTCATCTTTTCTTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTAGTTTTTGTTTTATTTCTCCGTTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCCTGAGAGCCGAGGTTTGTCGCAATGGAGAGGTGTTTGATAATATTGACTCAACATTGAGGACACGCTTGATTCACTTTATTGTCATTATCTATCGTTGGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTACTTAAAAATAGCCTCCCAAAATGAGTTTTTTCTTTATTTAAAAGAGATGTATTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTATTTTCCGGATATTACATTAAGTGTTTTAGTTGTTTGAGGTTGTGCTCTCAAGAGCACTTAAAATTTTAAGTGGATGTCTTTTACATCATGTTCCAAACTTGCTCTCCATTCTGTTTACGTTTACATAGTAGAGCAGAGTGGAGAGCAAGACTAAACATGATAAAAAGATCCATAAAAAATTTTAAGTGTTTCGAGCATGGCACAGGCAAAACGCAATGTAATATCGGAAAAAACAACTTTAATTTTATGACGTCGAACCCGGCGGCTCTGTTAAATAGCTTTAGGCGTCTCTTTTAAATGAGAAACTGACTTTAATGTTCACGACATGTGGACACATCAAAAAATCATCCATAATCTTATACACATCTGACGCTGCCGACGACAGA
+
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
@51cd0dc3-fdbc-4ec1-8f4b-c55f7a2190b2
CGGTAGCCTTCGTTCGGTTACGTATTGCTGCGCGCACTCTCTGAGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGGTGCTATTTTCTACTTCAAAGCGTGTCCTGGATGCTGTTCTGGAGTTCGTTCTGCGAGAGTTCGTGCAGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCAGGTGCGTCCAGTTTTTCGAGCAGCGTCGGGCTCTGACTTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCTGCTTGTTCATCTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTGCTGCCCGTTATTCTGCCGCTTTGGCTTTCTGACAGGCATTTGTCAGACAACACTGTCACTGCCAAAAACTGCCGTGCCTTTATCCCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAGGGCTTTGCCCCATGACTTACCCATGTCAGATACGGAGCCATGTTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGACAGCAGAGAAGAAGACCGGGAAATCAGAAGAACTGCTGAATGCAGCAGAGACCGTTCCGGTTTACGGGCGGCAGCTCTCGGTAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATACGCGGAGGTGCTGATCGCTATTACAGGTATCACCGTACCTATTATCAGACTTATAGCAGATTAGCTTCCCGGAGAAAACTGTCAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGGCCGCATCCTTCCTGTTTTCGAGGTAAAACATCTCTTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAAGATCTTCTATTGCGCCATTCTTGTTTTCTGGCATGATAAAGAAAGATATTTTGTACTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGAGTAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCGAAAACGATTCGTCGGCATCGATGATTAGAATATACTTTCTTTTTCATTAAAAGACTCTATACTTTTAAATGCCTCTAAGGGAGTTTTGTTTAGTTTTGTCTTTCCATTTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCCAAGTAGATTGCAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGGCTTTTTATAATCATTTATTTTTCTCGGTTTCATTGTCTACCTCCCAGCCATTTTCAACTGAAAAGAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTGGCTATTGGTTTTGCTGCTTTAATAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTCTATCTCATCAATGAGAATAATTGAGTCTTTTGAACTAAGATTGAGCTAATGAAAAGACATCTGCCTCCTTCACAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCAGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTTTGTGTTAGTAGTTTTGGTGTTTTTTGTCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTGTATCGCTGCGGTTTTGAGATTCATATAACACAACTTTTTTAGTTTGTTTTATTTCTCAGTTTATTTCTTGTGCTTTTGTATTATTGTTTTATAGTAATCATCAGCTTTAGGGGGTTCTTTCCGTTCTGTGTTTCTACGCTAGCAACGCTTAATCATTAAAACATTCCCGCTTTTCCACCTGAAACCGAGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTCCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTTCTTTATTTAAAGAAGATGCTTCATTTCTAAAGCTTTTTACTTTTAACGCAGAGCTGCTGGGTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCATGTTTTCCCAAGGAGTTGTTTTTCCGGATATTACATTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCTCTCGAAACATAAAATTTTAAGTGGATATCTTTATCAATAATTAACTTACTCTCATTTCTGTTTACGTTTACATAGTGCTCAACAACACCTTTAGCATGCATCACTATACCACTGTTTCTTTTCTAGAAGTATGATCAAAATATGTGCTTTACATAGTCCTGTTTGGATTGATTTAACCAGTTTGTCGGAGTCTTCTTGTGATTATTATTGTATTCTGTGGTCGTAATCTCCCTAGAAACTGAAAACAGAGAACTACACCTGCAGGCTCTGTGGTTGATCGAGAAAAGGATGCAGGCTGCAAGTCAGTACT
+
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
@3d6bdcab-ef5c-4ff8-a928-23066fb4e887
GATGTGCTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGGTCTCTGGGCTCGGAGATGTGTGTATAGAGACGCTGTTATCAGACTTATGGCAGATTAGCTTCCCGGAGAAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAAGTGATCACCATTCATCATGCATAGCTATGCGGGCAGACTGCGAAAACGATCCTGACTCCTTCCTGTTTTCCGGGGTAAAACATCTCTTTTTGCGGTGTCTGCGTCAGAAATTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTGTATTGTCTTTGTAGTCATTTACTTCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTTCATTATTTGGGTAAGCGTAATCCAGGATCTAGAATAGGCATATCAGTGAAAAAGGCGCTCCTGACCAGTGAAGAGGCCATATCTGACCTATTCTGCTGCCATCAGCAAT
+
$$%%%&013/7>4+'.386@D8338>?HB2;15%%0+2(91<>;>8:-*,--.2&*'--<4/4'2-.,4&%%*,&12551)$>,,/,,,AE??>==?6/.'''-8>B03<+,,-=CA@<A@<A98=<17581:*0<BC66@AA<>;;/09:6470999-%171+98==8<;6#'36;AC;7:689<<89%*./(&$++$-+--<-;=>55:4;*%&%*%/454@CAHA/318?G?4599=9?DEA@?EA@5?(0@B>CE?<3.,%&%$%%+95?2.49;?=416:55?4-18<>CDBF<0?-;--2;>ABC998:=;&$.)-/:89=:=$$)(18022*%%(0'867%%A9555317::8;-0586??,7.;A;=GE@>?<948>?@>EBA<<=?>./546/A7=7B;9<A648;&*E+&>@</>=DENF;C@=79;::<;:91/.,(,%%(#025<370=<=7/503=<>9<+,2:89<358;9FJD@CCCJB?=66:=</68KC@;;;7-.07-021%&(5:<99%%4.99;566;9517((44+(()-&*''$$$$#++)166(,'('#$&'/%$$)$&*()$+(+5**%#%$&$&#&$$*(%')(%$#&$%#
@ba3e1438-5606-4371-aab8-b41abb82649a
TTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCAGTGCGTACAATTACAACATTGTAAATTTTATAATTGTCTTTAGTCATTGCGCTATATTGATTTTGTAGGAACGGAGTTGTTTCATATTTTTGATATAAATTCTTTTCTCACTGAAACAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTAATACTGTTATCACAGAATCTGATTCCTTAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATACAATAATAGATTCTTGTTCTTTTATTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGTGAGCAATGAAGTTAGATCTTCTATTGCGCCATTCTTGTTTTTCCTGGCATGATAAAGAAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTACGTGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAAAATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATACTCTAAGGGTTTGTTTAGTTTTGTCTTTCCATTTTATTTTTTCAACACTAAGCTTATCCATTAATTCCTTCCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTCTCGGTTTCATTTATCACCTCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTGAGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTCTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTCTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACCGGAAGTAATGAATTCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTTCCTTTACTCCTTCACCAAACATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTTTCTTTGTTTTGATCTGTTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTGTGTTAGTAGTTTGTTACGTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTGAATTCACTATAAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTATAGTAATCAATTCTTCAGGGGGTTCTTTTCCGTTCTGTGTTTCACTAACC
+
D>%0/1;71>867,(8A4;=:83>@FA/.*1&16<?@67/.'33203/:;@96=4?''<458,2.39FIOFE9?BAE=9;A<?597B79=01++:2,*+')+(+33-&%./$&)%+&1&,<=?KCBCD<5211?>BBGCC%;;<77;0-<>67599A.<874>6022,2(061&389847IFOF;?*3;<6(((.0//7,21*$)&%%-,,2,4*++&,$)$$03351*65<=@9DFB**3>@AML<:@BA1;<HG??DA9::?33;?56>>EGHH??8?<:2C733<36*')16747/81114&(29=>9;52.+.5/%%)9AH=H9962**-(/77,84>300'%367;;55:31)/%'-/*+%$*,-,+(,(/1''9;?B59.1/2,08<<6688=C=:;>;8&)%%,1,:>@=@?=':544.;A;D@=<-<5;>@;>=JIACMFIFC=<=KEBFHF<=A9:9/..$'%#%$0'7GF;9F<1/&>A259:BAB:<HAD8HCB<><ACA:;DA@=B>@.(,&#-.0-++&#(76;?05:>:=46A>75712&&$%$(*+4:I?@?C@C@>A@??0/6@432210/++-.+9;0''==<6$$578@D<9EFBA=BBMJ?44A>B>B<ABE?9<;JCF<=61--,,&'(/005%%1915@?>A8:9?)*GBA@&:;58??;0098B>>+-<:;/>65>GC<CB@CB>DA?>:8:11;@A<:;55600DE>2<8;<:@AGJF>?>DB=8@06DEM=7@AB;7*&&&.,6.3:>@BARE?$$888:RG8',1/CAD=CB=BDI65DE6:DGJ:??@D<;/*&&#=IBNH?=83@B>89=>=<?A;@<365)04893.&&/%&3<DBEC<=BCA<?<MJB5>?BD@EGJ>8:5*./6-.2295;.1<91;43=0732-$%'079<IIBBACD@@HEGHFVJ=HG:BE:<ECEBC9;;5'')(871@<<879AHDF1)@(A@<=GA9;7++$$)*,+'9:=@=?>=;)49;BE6=:C89&B;:=5542414HB9:91/&8=>LHNF>32,&/22)99>97ABA57;<;3)/,4025+55/62#$$'.('+485,)**,01&057>BE>?;?IEAEE>.2'-AE665,7779;BB71=7EHC;;;/(4,+1026><<>HB>:1:73*+*;>BGKHCA78;,>@CED>D<DA555591>:=<;><882%1122&&95;687:56:8CDK:@>AF?OH8JDIE(*(/348;4BD?7,+/%.328C?;=(8>:7=?@HHC?<6/:;><<<477<<C3(26BA:<A:47,01%77:=>@999<,1$#%$(018666?9<?=OKB;3>@AB:>?HD<<<D9<7;:MKD==:A7C@=??9:;HFE/:=@B>>><<A3+33972A;<9<<>1('+/-,<7:1:8D@<?;FDBA=;>;;@@?;'55:8
@42c446ee-0e5e-4f63-9772-4958f7a55907
TTGCGGTGTCTGCGTCAGAATCGCGTTTCAGCACTTGTTCAGCGAATGCATACAATTACAGCATTATGTTAAATTTACATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTTCATATTTTTGATATAAATTCTTTTATCTCCCTCTGAAGCAGTCATCGTCAGTATCAATGGTTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAAAGGATGTAATAATAGATTCTTGTTCTTTTGGCTATTGAATGAATCGTCTGTATATCTAAACACTCTTTCTTACACGCGTGAGCAATGATTAGATCTTCTATTGCGCCGTTCTTGTTTTCTGGCATGATAAAGAAAGATATTTTTGTGCTTCTACCGTTAATGGCTGTTTCATTGGCACGAAGAGCTTGGTGATGAAATGTTAAGCTATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCATTGATGATTAAGAATATACTTTCTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTGAGGTTTGTTTTTAGTTTTGTCTTTCCATGGTATTTATTTTTCAACATAAACATGTTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTTATAATCATTTATTTTTCTCGGTTTTCACATTTATCTCACCTCCAGCCATTTCAACTGAAAAGAAAAAAATCATCCATATTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTGGTCTTATG
+
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
@a32eb9af-e584-43b7-bdc2-3d8cb22a8475
TTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAACAGTGCGTACAATTACAGCATTATGTTAAATTTATAATTGTCTTTAGTCATTGCGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTTGTTCTTCGTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTTTCTTTTCATTATTTGGGTAAAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTATTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGATTAGATCTTCTATTGCGCCATTCTTGTTTTTTTTCCTGGCATGATAAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAA
+
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
@cceb33ed-6947-434e-9631-c09b0df9a8b1
TTGCAGTGTCTGCGTCAGAATCGCGTTTGGCGCATTCCCCGGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTGAATATCTATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTGCAGTACCAAATTCTTTTTCACTGGAAGCAGTCTCAGTATCAATGGTTTTGTTCTTCATTGATATACTGTCTTTACACAAGTCAGTTCCCCTTATTACAACTAAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAAGCGTAATCAGGATCTAAGGATAATAATAGGTGCTTGTTCTTTTATTTATTGAATAGATCGTCCTATCTAAGCACCTCTTTCTTACACGCGTGAGCAATGGTTAGATCTTGCACCACCATTCTTTGACTTTCCTGGCGCGGTAAAGAAAGATATTTTTTGTACTTCCGTTAATGGCTATTTCATTATCCCGACGATGAAATCGTAAGCTCATTTTAATGTTGAAATATCGATATTTTTCCATTATTAAAGCAAATTCAAATAACATCGATGATTAAATCTTACTTTCACTCTCGTAAAGACTCTGCTTTTTAAATGCTCTAAGGGTTTGTTTTTAGTTTTATCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTCAAATGGAATTGCAAAGGAAGTGAAAATCATCATCACCTCAACAAATGGCTTTACAATCATTTATTTTTCTCTAGGTTTCATTTTATCTCCTCCAACCATTTCCAGCTGGAAAGGAAAAATATCTCATGTTCAAATTGTTCTCTGGTTTTGGATTCCTTCTCCAAGTCTTATAAGATCACCATATCTTTT
+
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
@2ece1f0f-8b91-4bed-aee0-1b72c4ff0c2f
CGGCGTACTTCGTTCAGTTACGTATTGCTGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAACAGCGTCAGCATCAGGTGCGTCAAGTTTTTCGAGCAGCGTCAGGCTCTGACTTTTATGAATCCCGCCGCTATTGGTAGCTTGCTGCTGCGATTTCATCTTTCGTTTCTCCGTTCTGTCTGTCATCTACGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCCGTTATTCTGCGCTTGGCTTTTTGACACATTCACCTGTGAACAACACTATCACTGCCAAAAACTGCCGTGCGGCTTTGTCAGTGAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTTGTTATACCGCGCATACATGCACGCTATTACAATTACCCTGGTCGGGCTTTGCCTTTATGGCATTCCACCATGTCAGATACGGAGGCCATGTTTTGTGATAAAACAGAAGCTGCATGATGTACGCACACCGAGGCGAGCGCCATCGTCGCCTGTTCGTCTGACAGCAGAGGAAAGACAGGAAATCAGAGAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTTACGGGCGGCAGCTCTCGGTGAAAGTTAACTCACTGACTGATGATCAGGTACAGAAAAGTTATAACAGGACTGGGGCGTTACAAGGAAAGAAACTCTTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCCAGGTGCTGATCACTTCCACGGAAGGGTATCGCATTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAAGCATCGAAAACAGACGGTATGAACACGTAAGCTCCCAAAGTGATCACCATTTCGCTTTCATGCATGGCTATGCAGCGAGCTGAAAACACGATCTGACGCATCATGTTTCCCGGGGTAAAACGCATCTCTTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCCGTTTCCAGCAGTGCGTACAATTACAACATTATATTTAATTTTATAATTGTCTTTAGTCATTGCACTTTATGATTTTGTAGGTGGAAGTTGTTTCATATTTTTTGATATAAATTCTTTTATCTCACTGGAAGCAGTCATCGTCGTCAGTATCAATGGTTTGTTCTTCATTTCAATATTTTTCTATTCTAGAATCTGATTCCTTGTACAACTAAGGTAAACTTCGAACTTTTTTTCTTTTCCATTATTTGGGTAAAGCTGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAAGCACCTCTTTCTCTTACACGCGTGAGCAATGATTAGATCTTCTGTTGCGCCATTCTTGTTTTTCTGGCATGATAAAGAAAGATATTTTTGTGCTTCCGTTAGCCAAGCTGTTTCATTGTGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTTTAAATGCTCTAAGGGTTTGTTTTTAGTTTGCCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAGAAAACCATCACATCCCTCAACGAAAATAGCTTTTTTATAATCATTTATTTTTCTCAGTTTCATTTATCTCACCCCTCCCCAGCCATTTTCAACTGAAAAGAAAAATCATCATGTTAAATTGCATTTGCTGTAGGTTTTGAGATTCCTTGTCTCTTCCCAGAATCTTATGTAAGATATATCTTTCTTTTTTTTTTTTTTCATCTAATTCGTTTATCGCATATTACATCATGGCTGTGTGTTTGTTGCCAAATATTTGATTATTATTGGTTTGCTGCTTCTATCAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTGCAGACTAAGGTCAGGCTAACGAAGACAGCGCTCTGCTTACTCCTTCACAAGCATTGATATTTCCTTCAATTCACTTGAGTCCTATATCTCAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTTTAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCCTGTTATTTCATCTTTTCTTTTTTGTGTTGAATAGTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTATATAGCTTACCTTTTTAGTTGTTTTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTTCCGTTCTGTGTTCACTAACCAATCATTAAAACATTCCCCTTTTCCTGAGACCGAGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGGGGACACGCTTGATTCGCTGTAATGTTATCTATCGTTGGTATTTTTGTATTACTTCTGACCTTTCACATCTCTTATTATTATGGACATTTCTTTGGATGTGTCCATGTTATAAATAACTATATCCAAAATGAGTTTTCTTTATTTAAAAGAGATGCTTCATTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGAGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGGGTTGTTTTTTCCGGATATTACATTAAGTGTTTTTAGTTGTTTGGGAAGTTATATCGAAACACTTAAAATTTTTAAGTGGATATATCTTTTTTATCATGTTTAAACTTGCTCTCCATTTCTGACTTTTACGTTTCATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGATTGATTTTAACAGTTTGTCAGGTTTCTTTGTGAATTCTTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACAGAAAAACCACCTGGGAGGGTGGTTTGATCGAAGGTTAAGTCAGTTGGGGAACTGCTTAACCAGGTAACTGTCTTATTGCGAGACAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACAATGGCTGCTGTGATGGCGCTGTCGTGTCTTACCGGATTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGTTCGTGCACCTGGCCAACTACAGGAGCGAACGACCTACTACCGAACCCGAGATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTGGAAGGGAGAAAGGCGGACAGGTATCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGCTTCAGGGGAAACACCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCCGGGCGTCGATTTTTGTGATGCTCGTCGGGGGCCGGAGCCTATGGAAAAACGCCGCCGGCGCTGAAAAGCCTCCGGTGCTTTCTTTTGCTCACATGTTCTTTCCGACTTTATCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGGTGAGCTGACACCGCTCGCCGCAGTCGAACGACCGAGCGTAGCGAGTCAGTGAGCGAGAAGCAGAAGAGCGCCTTATGTGACATTTTCTCATACGCTCTGTTGTGCCGTTCATCCTGTCCTGAGCGTTATCTCTCTAATGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTTGCGAGTTCATTACAGCTTCTCACACATAGCAGCCTGTTCGTCAGCATCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAG
+
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
@f73fd077-df92-4db8-a547-071e8fa36d21
GTTGCTTAGCGTTCAGTTACGTATTGCTGCGCGCACTCTCTCTGGTCTCGTGGGCTCGGAGATGTGTGTAGAGACAGGAACACCGTAAGCTCCCAAAAAGTGATCACCATTCGCTTTGCCATGCATAACGCTGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGATCCCAGGGTAAAACATCTCTTTTGCAGTGTATCTGCGTCAGAATCGTTCGGCCTCGTTCAGCGGTGTGGCGTTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATTATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGCTTTTGTTCTTCCATTGATATGCCTATTCTAGAATCTAATTCACTTATTACAACTAAGGTAAGCTTTGAACTTTTGCTTTCTTTTTTTGCATTATTTGGGTAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTTATTGAATAGATCGTCTATATATATCTAAACACCTCTTTCTTACGCGTGAGCAATGATTAGATCTTCTATTGCGCCATTCTTGTTTTCCACTGGCATGATAAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAACTCATTTACTGTGTCAAATTACTCAGATAACCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTCATTAAAAGACTCTATGCTTTATATGCTCTAAGGGTTTGTTTTAGTTTTGTCTTTCCATTTATTTTTCCGACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTCTGTTTTCAGTTGTTTATCTCACCTCCCAGCCATTTTCAACTGAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTACAGGTTTTGAGATTCCTTGTCACCTTCAGTCTTATGTAAGATATATCTTTCCTTTTTCATCTAATTAGTTTATCGCACGCATATTACATCATGGCTATTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTCTTTCGCTTCACCTATCAAAGCGTTGATCATATCTTTGGTTACTGAGTATTGACTGTCTCTTATACACATCCTGACGCTGCCGACGACGA
+
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
@45e299c5-b2e0-4688-bb95-20152b662d39
GTTATTACTTCGTTCCGGTTACGTATTGCTGCGCGCGCACTCTCATCGTCAGCAGCGTCAGATGTGTATAAGAGAGACAGTTCAGGGGAAACACCTGGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTTGTGATGCTGCTCGTCGGGGGCGGAGCCTATGGGCGCCTGCGGCGCTGGCCCTCGGTGCTTTGCTTTTTTGCTCACATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTAAGCTTTTGAGTGAGCTGACACCGCTCGCACCGGTCGAACGACCGAGCGTAGCGAGTCAGTGAGGAAGCGGAAGAGCGCCTTATGTGACATTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATGGCAACCTGTTCGTCAGCATCGGGTGCGTCAGTTTTTCCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTTGACGGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGTCCGGTAATTCAGGCTTGCTGACAGGACAGGATGTACGAATTGTTATACCGCGCATACATGCACGCTATTACAATTTGCCTGGTCAGGCTTTGCCCCGACGCCTTACATGTCAGATACGGGCCATGTTTTATGACAAAACGAAGTGGAGTAATACGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGACCAGGAAATCAGAAAAAGGGCTGAATGCGGCAGACCGTTTCCGGTTTTTTACGGGCGGCAGCTCTCGGTAAGAGAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGCGTTACAGAAAAACTCTTTATCGACGGCAAACGTGTCGGGGACAGGGAGTATGCGGAGGTGCTGATCGCTATTACGGAGTATCACCGTGCCTGTTATCAGACTTATGGCAGATTAGCTTCCGGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCTGACGCATCCCTTCCTGTTTTCCGGGGTAAAACATCTCTTTTTGCGGTGTACTGCGTCAGAATCGCGCTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCGATATGTTAAATTTTATAATTGTCTTTAGTCATTTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCCTAAGAATCTGATTCATATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTTTCATTATTTGGGTAAGCGTAATCAGGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGATTGGGAATCTTCTATTGCGCCATTCTTGTTCCTGGCATGATAAAGAAAGATATTTTTGTTTCCGTTAATGGCTATTGTTATGCGAGCTTAGTGATGGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTTAGTTTTGTCTTTCCATTTATTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAATCATCATCACCCTCAACGAAAATGACTTTTTTATAATCATTTATTTTCTCGGTTTCATTTATCTCACCTCCAGCCATTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGCTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTTCTCTGCTTACTCCTTCACCAAACATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCATTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTTCATCTTTTTCTTTTTTGTGTTAGTAGTTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTGAATTCATATAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTATAGTAATCAATTCTTCTGGAGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCCTGAGAGCCGAGGGGTTTGTCATAAATGGAGGGTGTTTGATAATATTGACTCAACATTGAGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTCTTTATTTAAAAGAGATGCTTCATTTCTAAAGCTTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTTCGGATATTACATTAAGTGTTTTTAGTTGTTGAGAGTTATGCTCTCGAAACACTTAAAATTTTAAGTGGATATCTTTTATCGTAATGTTTAAACTTACTCCATTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAGCTCCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACAGAAAAAACCACCTGGGGAGGTGGTTTGATCGAAGGTTAAGTCAGTTGGGGAACTGCTTAGCAGGTAACTGTCTTGTGCGAGACGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGCTTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCCGGGCTGAACGGGGGGTTCGTGCACACAGCCAGCTTGGAGCAGCCGGCCTACACCGAACTCGAAGGTCTACAGCGTGAGCTATGAAAGCGCCACGCTTCCCGAAGGAGAAAGGCGGACAGGTATCCGAGGCGGTAAGCGGCGGGGTCGGAACAGGAGAGCGCACGAGGGGGCTTCAGGGCTGTCTCTTATACATCTCCGAGCCCACGGGGCCAGAAGACCTGCGCGCATAACCGAATACTTGCGGCCAAC
+
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
@d1da1c6f-7879-44a6-ad8f-d1bab3758d2b
CGGTACTTTGCGTTCCAGTTACATATTGCTGCGCGCACCTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAACAGGAAAAGTGGTACGCGATATAATCTAGCACCAGATGACAGACAGAACGGAGAAAACGAAAAGATGAACAAGCAGCAGCAGCAAGCCCGGCACTCAACATGGCGGGATTCGCAAAAGTCAGAGCCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTATGTGTTGAAAGCTGCACGAACTCATGAAGAATACCAGAACAGCATCCAGACACTTTGAGTAGAAAATGGCACAGAGAGATAACGCTCAGGACAGGATGCCGAACGGCTGTAGAGCGTGGAGAAAATGTCACATAAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCATACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCAACTCACTCAAAAGCGGTAGCCACGGTTAACTCCACAGAATCGAGGATAAAGTCGGAAAGAGCATGTGAGCAAAAAGCCACCGGAGAAGCCAGCGCCGCAGGCGTTTTATAGGCTCCGCTGACGAGCATCACAAAAATCGACGCTCAAGCCAGAGGTGGCGAAGCCCGACAGGACTATAAAGATACCAGGTGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCCTGCCGCTTACCGGATACCTGTCCGCCTTCTCCTTCGGGAAGCGGTAGCGCTTTCTCATAGCTCACGCTTTGTAGGTATCTCGGTTCCGGTGTGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCGTTCAGCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCTTCGTGCGGGCTACGATGGCTGGCGGCAGCCATTGGTAAAGTCGATGTGCGAGGTTCAAGAGAGTACTTGAAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTTAACTGACTTAACCTTCGATCAAACCACCTCCCCAGAATTGGTTTTTTCGTTTTCAGTTTAGGAGATTACGAAGCCAGAACACAATAATCCGCAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCCAAACATGGGACTATAAAGAAGTAATATTATTTTGAGGATTATACTTCTAGAAAAGAAACGGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACGCGATGAAGATATCCATAAAAAATTTTAAGTGTTTCGAGAACATATCTCGAACAACTAAAAACAATGTAATATCCGGAAAAAACAACTTTGGGAAAACATCGATGTGGGCGCGATATTTTCGTTTTATATCGACGTAAAACCCAGCGGCTTAAAAGTAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAGAAAACTCATGGGATAGCTATTTTTATAACATGGACATCAAAGAAATGTCCATAACAATAAGAGATGAAAGGTCAGAAGTAACACAAAAAAATACTCAACGATGGATAACACACAAAGTGAATCGAAGCGTGTCCTCAATGTTAGTCAATATTATCAAACACCTCATTACGACAAACCCTCGGCTCTCAGGGAAAGAGAGAGTGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAAAGAACCCCCCAGAAGATGGTTACCACTAAAATAACACAAAAGCACAAGAAATAAACGGAGAAATAAAACAAATAAAAGGTAAGCTATATGAATTCAAAACCACTGTTGATAATAACCACATCAAGAAACATAAACAAAGAAGCAACGATAAAAAACGTATCAAACTACTAACACAAAAGAAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATAATAGAATTAACGACTTTTAGTAACTGCAACAGATCAAAACAAAGAAGTTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGGAGTAAGCAGAGCGCTGTCTTTCTAACTCAATCTTAGTTCAAAAGACTCAATTGTTATTGTCTCATTGATGAGATAGAAAATGGAAATTCATTACTCAGTAATCAAAGATATAGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACAATTAGATGAAAAAGAAAGATATATCTTACATAAGACTGGGAAGACAAAGATCTCAAAACCTACAGCAATGCAATTTAACATGGATGAGTTTTCTTTTCAGTTGAAGCCATTTGGGAGGTGAGATAAATGGAAACCGAGAAAAATAAATGATTATAAAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCCGCCTTTGCAATCTACTTGAAATAGAAGGAATTAACTGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTCAAAACAAACCATTACCTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACCTGGAAAGATCGATAATTTCAACATTAAATAGACTTAACGATATTTCATCACCAAGCTCGCATAATGCAAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATACCAGGAAAAAACAAAGATAGCGCAATAGAAGATCTAATCATTGCTCACGCGTATCAGAAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGACAAAAGTTCAAGTTTACCTTAGTTCGTAAACAAGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACATTATTTGCTTCAAGTGAGATAAAAGAAGAATTTATATCAAAATATGAAACAACTCACCTACAAAATCATAGCGCAATGACTAAGGTAATTATAAAATTTAACGCATAATGCTGTAATTGTACGCACGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAGAGTGTTTTGCCGGGAAAACAGGAAGGATGCGATCAGGATCGTTTCCAGCCTCGCTGCATAGCCTATCACACGTAAGCGAATGGTGATCACTTTGGGGGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCCCTCCGGGGCTTCTAATCTGCCATAAGTCTGGATAACAGGGCGGTGATGCTCACGTAGTGCGCGTCAGCACCTCCGCATACTCCCTGTCTGACACTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCAGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTAGGGACAACTTTCTTACCGAGCTGCCGCCCGTAAAAACCGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTCTGATTTCCTGGTCTTCTTCTGCCATTCGTCAGACGAACAGGGCGGCTAATCAGCCCCGCCTGCGTATTACTTCCACTTCGTTTTGTCATAAAACACTGGCTCCGTATCTGACATGGGTGTCGGGGCAAAGCCCTGACCAGAACAGTGTAATAGCGTGCATGTATGCGCGGTATAGCAATTGCACATCCTGTCCTGTAAGCTCGAATTACCGACAGAAGGCACGGCAGTTTTAGCAGTGACAGTGTTGTCTGACAGAAATGCCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAGCAAAACAGTCGAAAAGTGGCTGTCTCTTATACATCTCCGAGCCCACAGACCAGAGAGTGCGCGCGCAGCGATACGTGT
+
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
@11a3af27-479d-44fe-a1fe-214688f5e634
CAAATACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAGACAGGCGAGAGGTTCGAAAGTACTTGATGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTCCCCAACTGACTTAACCTTCGATCAAACCACCTCCCCAGGTGGTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAAGAAGAAACTCCGACCAACTATAGTTCTTAAAATCGTCTAAATGGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATAAGAGAGCAAGTTTAAACATGATAAAAGATATCCACTTAAAATTTTAAGTGTTTCGAGAGCATAACTCTCAAACAACTAAAAACACTTAATGTAATATCCGGAAAAAACAACTTTGGGAAAACATCGATATTAGACGCGATATTTCATTTTATGACGTAAAAAAACCCAGCAGCTCTGTTAAAAAGTAAAAAGCTTTAGAAATGAAGCATCCTCTTTTAAATAAAGAAAACTCATTTGGGATAGCTATTTTTATAACATGGACACATCAAAGAAATGTCCATAACAATAAGAAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTAGTCAATATTATCAAAACACCCCTCCATTGCGACAAACCCCTCGGCTCTCAGGAAAGAGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAAAAGAACCCCCCAGAAAATTGAGTTACTATAAAAATAACACAAAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAAGCTATATGAATTCAAAGACGCAGCGATAATAACCACATCAAGAAACATAAACAAAGAAGCAGCGATAAAAAACGTATCAAAACTACTAACACAAAAAAGAAAAGATGAAATAATAGGCAACCTAAAAAAGAATAGATAATAGAATTAACGATATTATTGCAATGATAGCAACAGATCAAAACAAAGAGATTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCGAATGCTTGGTGAAGGAGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAGCAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAGAAAAGATATATCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGAGGATTTTTCTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGTCATTTTCGTTGAGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATATATACAGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGTAATAGAGTCTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAAATGGCGCAATAGAAGATCATCATTGCTCACGCGTGTAAGAAGAGGTGTTTAGATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTTGCCTTAGTTGTAATAAGGAATCAGATTCTAGAATAAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACCTTCCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAGTGTTGCAGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTA
+
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
@8e489f55-5ca7-4682-9711-6eb4e1b11fe9
GTTATACTTCGTTCAATTCCCGGCATTACCGCGCGCCTCTCTGTCAGCGGCGTCGGATATTAATATAAGAGACGGTTCACTTTTCGTCTGGCTCGACAGTTTCTCTCCAGGAGAGCTAATCTGCCATAAATCAGTTCGCAGGGCACGGTGATACTGTAATAGCGATCAGCACCTCCGCATACTCCTGTCCCGACGCTTGCCGTCGATAAAAGAGTTTTCTGTAGCGCCCCCAGTCTCTTAACTTCTTTCAGTACCCGATCATCCAGTCAGTGAGTTAACTTTCTTTGCGAGCTGCCGCCCGTAAAAAACCGGGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTCTGATTTCTGGTCTTCTTCTGCCGTCAGGCGAACAGAACCGACTGATAGCCCGCCTGCGCGACAATTGCTTCCACTTCGTTTGTCATAAAACATGGCTCCGTATCTGACATGGGTGTCGGGGCAAAGCCCTGACCAGGGCAATTGTAATAGCGTGCATGTATGCGCGGTATAACAATTGCACATCCTGTCCCTGTCAGCAAGCTCGAATTACCGACAAAGGCACGACAGTTTTTGGCAGTGACAGTGTCTGACAAGAAATGCGTATGAAAGCAAGCGGCAGAATAACGGCAACCAAAACAGTCAGCAGTACGCGATATAATCACACAACGCAGATGACGGAACAGAACGGAGAAAACGAAAAGAAGATGAACAAACAGCAGCAAAGCCGTACTCAACATGGCGGAGATTATAAAGATCAGACCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTGCACGAACTCGCAGAAGAACTCCAGAACAGCATCCAGACACGCTTTGAAGTAGAAAATAGCACAGAGAGATAGCAGCAGGACAGGATGCCAGGCAGCTACAACAGAGCGTAAGGAGAAAAATGTCACGCTGGAGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTACGCTCGGTCGTTCTGGGCTGCGGCGAGCGGTGTCAGCTCACTCAAAAGCGGTAATACGGTTATCCACAGAATCCGGGGGATAAAGTCGGAAAGAACATGTGAGCAAAAACAAGCACCGGAGGAAGCCAGCGCCGCAGTACGTTTTCCATAGGCTCCGCCCCTGACGAACATCCACAAAATCGACGCTCAAGCCAGAGGTGGCGAAAGCCCGACAAGGACTATAAAGATGCAGGTGTTTCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCGGTTCAGTGTGGGTCGTTCGCTCCAACTGGGCTGTGTGCACGAACCCCCGTTCAGCCGCGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACGACAAAGCGCCACTGGCAGCAGCCATTGGTAAAGAATCGATGTGCCCGAGAGGTTCAAAGAGAGTACTTGAAGTGATGGCCTGACTACAGCTACGAAAGGACAGTTTGATGACTCGTCTCGCACAAGACAGTTACCTGTTAAAAGCAGTTCCCCAACTGAGCAACCTTCGATCACACTCCCCAGGTGGTTTTTAAGTTTTCAGTTTAGGAGATTACGACCAGAACACAATATCACACAGAAGAAACTCCGACCAAACTGGTTAAAATCAATCCAAAACAGATTTATAAAGTAATAATGTTTTTGATTATACTTCTAGAAAAGAAGCAATTAGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAGCAAAATGGAGAGTGAGTTTAAACATGATAAAAAAGATATCCTTAAAAAATTTTAAGTGTTTCGAAACATAACTATAAACAACTAAAAACACTTAGTAATATCCGGAAAAAAACGACTTTGGAAAACATCGATATTAGACGCGATATTTTTCATTTTATGACGTAAAAAACCCAGCAGCTCTGTTAAAGAGTAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAGAAAACTCATTTGGGATAGCTATTTTTATAACATGGACACATCGAAAGAAATGTCCATAACAATAAGAATGAAGGTCAGAGTAACACAAAATACTCAACGATGAATAACACACAAGTGGATAAGCGTGTCCCTCAAATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCTCGCTCTCAGGGAAAAGGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAAAGAACCCCCCAGAAGAAAGATTGATTACTATAAAAATAGCACAAAAGCACAAAGACAAACGAATAAAACAAACTAAGGTAAGCTATATGGTTCAGAAAACCGCAGCGATAATAACCATCAAAAACATAAACAAAAGAAGCAGATAACGTATCTGAAAACTACCTAACACAAAAAGAAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAGCAACAATTCAAAACAAAGAGATTTTTAGATATGGGGACTAAGTGGTCAAACAAATATCATGCTTGGTGAAGGAGTAAACAGGCACTGTCTTTCACATTAGCTCAATGCCCAGTTCAAAAGAACACAATTATTCTCATTGATGGAGATAGAAAATGGAATTCATTACTCAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAGCAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGGTGCAGCCAACTATGTTGCGATAAACGAATTAGATGAAAAAAGAAAAGATATATCTTACATAAGACTGGGAAGAAGAGACAAGGAATCTCGAAAACCTACAGCAATGACAGAATTTAACATGGATGATTTTCTTTTCGAGTTAGAAAATCGCTGGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGTCTGTTTTCGTTGAAGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAATAAATGGAAAGACAAAACTAAAAACAAACCCTTAGAGCATTTAAAAACATGATCTTTTAATGAAAAAGAGAGTATATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCTACCAAGCTCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCTTAGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATCATTGCTCACGCGTGTAAGAAGAGGTGTTTAGATATATAGACGATCCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCTCTGATTACCCCTTTACCCAAATAATGAAAAGCAAAGTTCAAAGTTTACTTAGTTAATAAAAGGAATCAGATTCTAGAATAGGCATGGCGTATCAATGAAGAACAAAAACCATTGATACTGACGATGATGAGAAGAGGAAGAAGAAGGCACAACAAATGAGGATAAAGGAATTTATATCAAAATGTGAAAGAACAACCACCTACAAAATCATGGCGCAATGACTAAGAAAGAGACAGTTTATATAAAAGTTTGATAATACTGCCTGTGGCGGCGATATGCCGCCTGTAATTGTACGCACCGCTGTGCTGAACGCGATTCACGACGCAGACACCGCAAAGAATGTTACCAGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTTGCCCAGGGGAGCTTACGGTGTTGTTTGTCTGTTCGATAGTTCCTGCCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCCAGCACCTCCACCATACTCCTGTCCCCGATTTTGCCGTCGATAAAGAGTTTTTCTGTAGCCAACGCCCCCAGTCTCGCAACTTTCTTTCATTTTGATCATCAGTCGAGATGCTTTCTTACCGAGCTGCCGCCCGTAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTCTGATTTCCTGGTCTTCTTCTGCCGTCAGACGAACCTGTCTCTTATACATCTGACGCTGCCGACGGCAA
+
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
@70422261-f625-402c-a7d2-15a5bc4ff4e0
TAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAA
+
/99.0=3+($$#&4(/,,,/694--435;8/**23<5:=+14557<13/0./**)55;>08CD
@7311edaf-1b27-4ff4-b013-15f2a8aa58b5
ACCTCGGTGACCCGCTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCAGCAATCAGACAATAATATAAGAGACAGGCCCTGACCAGAGTGTGGTGTAATAGCGTGCATGTATGCGCGGCATAACAATTGCACATCCTATCCTGTCAGCAGCTCGAATTACCGACAAAGGCACGGCAGTTTTTGGCAGTGACGGTGTTGTCTGACGAAATGCCCGTCAAAAGCCAAGCGGCAAAGATAACGGCAGCAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACAGAACGGAAGAAAACGAAAAGATGAACAAGCGGCAGCAAGCCGTACTCAACATGGCGGGATTCATAAAGTCAGAGCCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGTGAGAAGCTGCACGAAGACTCGCAGAAGAACTCCAGAACAGCATCCAGACACGCTTTGAGTAAATAGCACAGAGAGATAACGCTCCAGGACGGATGCCGAACGGCACAACCCAGAGCGTAAGGAGAAAATGTCGCAAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCAGCTCACTCAAAAGCGGTAATACGGTTATCCACAGAATCGGGGATAAAGTCGGAAGAACATGTGAGCAAAAAGCAAAGCACCGGAGGAAAGCCAGCGCCGCGAGCGTTTTCCATAGGCTCCGCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCGGGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGTGTTTCCCCTGGAAGCTCCCTCGATGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCGGTTCGGTGTAGGTCGTTCGCTCAAGCTGGGCTGTGCACGAACCCCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACAAAGCGCCACTGGCAGCAGCCATTGGTAAAGTCGATGTGCGAGAGGTTCAAAGTGGAAGTGATGGCCTGACTACAGCTACACTGAAGGACAGTTTTGGTGGACTCGTCTCTCGCACAAGACAGTTCCCTAGTTGGCTGGTTCCCAAGCTGACTTAACCTTCGATCAAACACCACCTCCCCGGGTGGTTTTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAAGGAAGAAACTCCGACAAACTGGTTAAATCAATCCAAACAGGACATTTAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAAACAGTGGCATAGTGATGCATAAATAAACACATTACTATGTAAACGTAAACAGAAATGGAAACAAGTTTAAACATGATAAAAGATATCCATAAAAAATTTAAGTGTTTCGAGACATAACTCTCAAACAACTAAAAACACTTGTCTTAATATCCGGAAAAAACAACTTTGGGAAAACATCGATATTAAGGCGCGATATTTTCATTTTATGACGTAAAAAAACCCAGCAGCTCTGTTAAAAGTAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTTGGGATAGCTATTTTTATAACATGGACACATCCAAAGAAATGTCCATAACAATAAAGAGATGAAAGGTCAAATGCTGGCTACTCAACGAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAAGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAAGAACGGAAAGAACCCCCAGAAGAATTGATTACTATAAAATAACACAAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAGCTATATGAATTCAAAACCGCAGCGATAATAACCACATCAAAAACATAAACAAAGAAGCAACGATAAAAAACGTATCAAAACTACTAACACAAAAAGAAAAGATGAAATAATGAGCAACCTAAAAATAGATAATAGAATTAACGATATTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGCTTGAGTTGAAGGAGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAAGACTCAATTATTCTCATTGATGAGATAGAAAAATGGAATTCATTACTCGGTAATCAAGATATGATCCAACGCTCTTTGATGAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAGAAAAATATATCTTACATGTTAAGACTGGGAAGAGACAAGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGGCGAAACCGAGAAAAATAAATGATTATAAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGAATAGCCATTAACGGAAGCACAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGAATGGCGCAATAGAAGATAATCATTTGCTCACGCGTGTAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGAAAACAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCAGTGAGATAAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAAATCATGACGCAATGACTAAAGACAATTATAAAAAATTTAACATAATGCTGTAATTGGCGCACCGCTGAAACGCGCTGAGCGCGATTCTGACGCAGACACCGCAAAAAGAGATGTTTTACCCCGGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTTCTCTCCGGAAGCTAATCTGCCATAAGTCTGGATAACAGGAGCACGGTGATACTCCGTAATAGCGTTCAGCACCTCCGCACTCCCTGTCTGACACGCTTGCCATCGATAAAGAGTTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCAGTACCCGATCATCCAGTCCTGTCTCTTATACATCTCCGAGCCCACGAGACCA
+
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
@84abf15d-99cb-4af1-af1c-caf087bf6318
GTTGTACTTCGTTCCAGTTACGTATTACTGCGCGCGCACCGCTCTCTGTCGTCCGGCAGCGTCAGATGTGTATAAAGAGACAGGTCCAACCCGGTAAGACACGACAAAACGCCACCGGCAGCAGCCGTGGTAAAGTCGATGTGCAGAGGTTCAAGAGAGTACTTGAAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGGTTAAGCAGTTCCCCAACTGACTTAACCTTCGATCAAACCACCTCCCCAGGTGGTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAAACAGTGGCATAGTGATGCATAAATAAGCACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACATGATAAAGATATCCACTTAAAAAATTTTAAGTGTTTCGAGCATAACTCTCAAACAACTAAAGCAATGTAATATCTGGAAAAAACAACTTTGGGAAAACATCGATATTAGACGCGATATTTTCATTTTATGACAATAAAAAACCCAGCAGCTCTGTTAAAAGTAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTTGGGATAGCTATTTTTATAACATGGACACATCAAAGAAATGTCCATAACAATAAGAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACAAAGTGAATCAAGCGTGTCCCTCAATGTTGAGGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCCAGGAAAAGAATGTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAAAGAACCCCCAGAAGAATTGATTACTATAAAAATAACACAAAAAGCACAAGAAATAAACGGAGAAATAAAACAAATACAAAAAGGTAAGCTATATATGAATTCAAAACCGCAGCGATAATAACCACATCAAAACATAAACAAAGAAGCAACGATAAAAACGTATCAAAACTACTAACACAAAAAAAGAAAAAGATGGAAATAATGAGCAACCTAAAAAGAATAGATAATAGAGATTAACGATATTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTTAGATATGGGACCCCAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGGGGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGCGAGATAGAAAATGGAATTCATTACTCAGTAATCAAGATATGATCAACGCTTTGATAGAAGCAGCAAAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAGAAAAGATATATCTTACATAAGACTGGGAAGAGACAGGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTCAGTTGAAAAATGAAGCTGGAGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAAATAAATGGAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAACAAGGAATAGCGCAATAGAAGATCACAATCATTGCTCACGCGTGTAAGAAAGAGGTGTTTAGATATATAGACAGTCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCAAATAATGAAAAGCAAAAGTTCAAGTTTATCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACGGCTTGATGAGGAAGCTGCTTCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAAGATGTTTTACCCCGGGGAAAACAGGAAGGATGCGATGGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTTCTCTCCGGGAAACTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGTCAGCACCTCCGCATACTCCCTTTGTCCCCGACACGCTTGCCGTCGATAAAAGAGAGTGCGCGCGCAGCCGTACGTAA
+
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
@c1461bee-6567-42f7-a7d2-1034f1ef8cd3
ATCAAACACCCCTCATTGCAATAAACCCTCGGCTCTCGGAAAGGGAATGTTTTGTAATTAAGGTTAGTGAAACACAGGCTGAAAAAGAACCCCCAAAAGGTAGTTCTATAAAAATAACACAGCTGCAAAATAAACTGAAATAAAATAGGCTAAAGGTAAGCTGGATTCAAAACCGCAGCGATAACCACGTAAACAGCAAACGAAAGAAGCAGCGATAAAAAACGTAATATCAAACTACTATACAAAAGAAAAAGATGGAAATAATAAGCAGCCCAAAAGAATGAATGTAGGTCTTAAATATTGCAATAATGACAGGTCGTCGAGATTTTTGATATGGACTAAGTGAATTAAATGGAAATAAAGTAGCGGGTATGAGAGTAAGCAGAGCGCTGTATCTTTATTAGCTCAATCTGCCAGTTCAAAAAGACTCAACGTTATTGTCTCAACGATGAAGTAAAAATGGAATTCATTACTCGATAATGCAAGATATAGTCAACACTTTATGTAAAGCAATAAAAGCAATAATAAATATTTACAACCTAACACACATTAGCGATGTAATATGTGCGATAACATGATAGATCTTTGAAAAAAGAAGATGTATCTTACATAAGACTGAAGGAACCATAAGGAATCTCAAAACCTACAGCAATGCAATTTATAACTTATGGATGATTTTTCTTTTTCAGTCTAAATATGGCTGGAAGTGAATCGTGACGAGAAAAATAAATGATTATAAAAAGTCATTTGTTGCGAGGTGATGACATTAATTTATTGCAATCTACTGCCCAAAATAGAAGGAATTAATGATGTTTATGTGAAGAAAAATAAATGGAAAGAATAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATACAAAGTCTTTTAATGAAAAAAAAAAGTATAATCATCGATGCGACGAAATCGTTTCTGACTTTGGAAAGAGATCCGATAATTTCAACTAAATAGACTTAACATTTCATCACCAAAGCTCGCCAGTAATGAAATAATATAACGAAACACAAAAAATATCTTTCTTTATCTTTTGGGAGAAAAAACAAAATGGCGCAATGAAGATCTAATCATTGCTCATAATGATAAATAAGAAAGAAGTGTTTAGATATATGGGCAAATCTATTCAATAAAATAAAGAACAAATCTATTATTACATCCATAGATCCTGATTACCACCCACCCAAATAATGAAAAACTAAAGTTCAAATTTACCTTAGTTGTAATAAGGGAATCAGATTCTAGAATAGGCATATCAATGAAGAATAAGCCATTGAGTGCTGACGAAGTGACTATTTAGTGGTCCACAAGGAATTTATCAAAAATGTGAAGTATAACCACCTACCGAGATCATAGCGCAATGACTAGAACTATGATATAAATTTAACGCAATGCTGTAATTGTGCGCACCGCTGGAAAAACACGCTGAACGCGATTCTGACGCAGACACCGCAA
+
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
@ace5dfc1-ada4-423f-80dc-74269395f845
CTTTTAAACAAAAACTCATTTTGGGATAGCTATTTTTATAACATGGACACATCAAAGTATCCCATAACAATAAGAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCTCCATTTACGTCAAACCCTCGGCTCTCCAGGAGAAGGGGAATGTTTTAATGATTAAGGTTAGTGGGAAACACAGAACGGAAAAAGAACCCCCAGAAGAATTGAGTTACTATAAAAATAACACAAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAGGTAAGCTATGAATTCAAAACCGCAGCGATAATAACCACATCAAGAAACATAAACAAAGAAGCAACGATAAAACGTATCAAAACTACTAACACAAAAGAAAAGATGAAATAATGAGCAACCTAAAGATAGATAATAGAATTAACGATATTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTTAGATATAGGACTAAGAATGAATTAAATGAAATATCAATGCTTGGTGAAAGGAGTAAATGTTGCTATCTTTTCATTAGCTCAATCTTAGTTCAAAAAAAGACTCAGTGTTCTCATTGATGAGATGAAAATGGAATTCATTACTCAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAATAAGTAAATATTTACAACAACACACAGCCATGATGGCTATGTGCGATAAACGAATTAGATGAAAAAAGAAAGATATATCTTACATAAGACTGGGAAGAGACAAGGAATCTAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCCTTTGTTAATTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAAGTCTTTTTTAATGAAAAAGAAAATATAATTCTGTAATCATCGATGCCCGTGATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATCATTGCTCACGCGATGTAAGAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACATACCCAAATAATGAAAAGAAAGCAAAAGTTCAGGATTTACCTTGAACATAATAAGGAATCAGATTCTAGAATAGGCATATCAATAGAGAACAAATGTTGATACTGACAGTAACTGCTTCAGTGAGATAAAAATTTATATCAAAAATATGTGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTCAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGCGATTCTGACGCAGACACCGCAA
+
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
@662a31e4-66c1-4353-a05b-19725f779a28
TCATAGCGCAATGACTAAAGACAATTATAAATTTGCCATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAA
+
58+)4,?;D994779-;<0/24@@@4+:342274%&&&&2889?>/*.//25-+110/0.69=@=CB=7%02588;964=<7:?:C?I66=9J<CA>45<=
@5b2bbfbb-f6ae-4a8d-b029-447edcd369ad
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGTCGTCTGGCAGCGTCAGATGTGTATAAGAGACAGTTCTTACCGAGAGCTGCCGCCCGTAAAAAACCGGAAACAGTAGTCTTGCCGCATTCAGCAGCGCTTTCTGATTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGTATTACTTCCACTTCGTTTTGTCATAAAAACATGGCTCCGTATCTGACATGGGTGTCGGGGCAAAGCCCTGATCAGGGCAATTGTAATAGCGTGCATGTATGCGCGGTATAACAATTGCACATCCTGTCCTGTCAACAAGCTCGAATTACCGACAAAGGCGGCAGTTTTGGCAGTGACGGTGTTGTCTGACAGAAATGCCCGTCAAAGCAGAAGAAGCGGCAGAATAACGGCAACAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACAGAACGGAGAAAACGAAAAAGATGAACAAGCAGCAGCAAGCCGTACTCAACATGGCGGGATTCATAAAAAGTCAGAGCCTGACGCTGCTCGAAAAAAACTGGACGCACCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTGCACTGACTCAGAAGAACTCCAGAACAGCATCAGACACGCTTTGAAGTAGAAAATAGCACAGAGATAACGCTCAGGACAGGATGCCGAACGGCGCAAGCAGAGCGTAAAGGAGAAAATGTCACATAAGGCGCTCTTCCGCTTCCTCGCTCACTACCTTTCCCGGTCGTTCGACCCGGCGAGCAGTGTCCAGCTCACTCAAAAGCGGTAATACGGTTATCCATCCAGGGATAAAGTCGGAAAGAACATGTGAGCAAAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCGGCGTTTTTCCATAGGCTCCGCCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCAGAGGTAGCGAAACCCGACAGGACTATAAAGATACCAGGTGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCGGTTCGGTGTAGGTCGTTCGCTCCCAAGCGGGCTGTGTGCACGAACCCCATTCAGCCCGACACGCTGCGCCTTGTCCGGTAACTATCGTCTTGAGTCAACCCGGTAAGACACGACAAAGCGCCACTGGCAGCCATTGGTAAAAGTCGATGTGCGAGGAAAGTTCAAGAGAGAATTACTTGAAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTCCCCAACTGACAGAAGCAACCTTCGATCAAACTCCTCCCCGAATTGGTTTTCGTTTAGGAGATTACGACCAGAACACAATCACAAGAAACTCCGACAAACTGGTTAAAATCAAATCCAAACAGGACTATAGAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTAGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAGTTTAAACATGATAAAGATATCCACTTAAAAAATTTTAAGTGTTTCTGAGCATAACTCTCAAACAACTAAAAACACTTAATGTAATATCCGGAAAAAAAAAACAACTTTGGGGAAAACATCGATATTAGACGCGATATTTTCATTTATGACAATAAAAAACCCAGCAGCTCTGTTAAAAGTAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTTGGGATAGCTATTTTTATAACATGGACACATCCAAAGAAATGTCCATAACAATAAGAGATCAGAGAAGGTCAGAAAACACAAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCCTCAATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAAAGGGGAATGTTTTAATAGTTAAGGTTAGTGAAACACAGAACGGAAAAAGAACCCCCAGAAGAATTGATTACTATAAAAATAACACAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAAAGGTAAACTATGAATTCAAAACCGCAGCGATAATATACATCAAAACAAACAAAGCAACGATAAAAAACGTATCAAAGCTACTAACACAAAAAGAAAAGATGAAATAATAGGCAACCTAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAGCAACAGATCAAGAAGATTTTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGGAGTAAGCAGAGCGCTGTCTTTCTAGCTCCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCAGTAATCAAAGATATGATCCAACGCTTTGATAAGAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAAAGAAAAAGATATATCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTTCTTTTTTTCAGTTGAAAATGGCTGGGAGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAAGAGGTCTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCACCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACCATTAAATGAGCTTAACGACTTTATCACTGCCAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGGAGATAGCGCAATAGAAGATCTAATCGTACGCGCATTAATAAGAAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAACAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGCAAAGTTCAAGTTTACCTTAGTTGTAATAAAGGAATCAGATTCTAGAATAGGCATATCAATGAAAAGAACAAAACCATTGATACTGACGATGACTGCTTCAGTGAGATAAAGAATTTATATCAAAAATATGAAACAACTCACCTACAAAATCATAGCGCAATGACTAAAGACAATTAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAGAGATGTTTACGGGAAAACAGGAAGGATGCGTCAGGATCGTTTTTCAGCTCGCTATAACTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTTCGACAGTTTTCTCTCCGGGAAAGCCCAATCTGCCATAAGTCTGGATAACAGAGTACGGTGATACTCCGTAATAGCGATCAGCACCTCGCGCTCCTGTCCCCGACACTTGCCCGTCGATAAAGAGTTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCGCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAA
+
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
@fa25be06-cfe3-44bd-a2f4-fe41c3d04e92
AATTAATGATGTTTATGATAAATGGAAGACAAACTAAAACAAACCACAAACGACCCAAAGCATCAGAGTCTTTGTGAAAGTATATGTAATCATCGACGGCGATCGTTTACCCGACGCGGAAGATCGATATTTCAACATTAAATGACTTAATATTGCATCACCAGCTCGCATAATGAAACCAATAGGACTAAATATCTTTCTTTATAAATCGCCGAAAAAACGAATGCGTAAGAAGATCTAATCGTGCTCGCGCTAGTCATAAAAAGGGTGTTTAGATGCTATAGACGATCTGTTCAGTAAGATAAAGGAGCAAGATCTATTGTACATCGCTTGAGTCCACAGTTACTTACCCAAATGTGAAGAAAGCCAAAGTTCAGGTTACCTTGGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATAACTGCTTCCAGTGAGATAAAAGGTATATCAAAATAACTAAAACAACTCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAATTTAACATAATGCTGTAATTGTACGCACCGCGCTGAAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAA
+
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
@b722fae5-77b2-4740-9dfb-9e04b7aa24c3
TGTTGCTGATTCGGTACGTATTGCTGCGCACTTTTCCTCTCTGTCGGCAGCGTCAGATCTATAAGAGACAGCGCTGTGGGTATCTCGGTTCGGTGTAGGTCGTTCGCTCCAGCCTGGGCTGTGCGAACCCCCGTTCAGCAAACCGCTGCACTTATCCGGTAACTATCGTCTTGATTAACCCGGTAAGGTACGACGCCAGCGCCACTGGCAGCAGTATTGGTAAAGTCGAATGTGCGAGGGGTTCAAAGTACCCGAAGTGATAGCCCACAATACAATACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCTACGAATTGATTACCTGAATTGGCGCAGTTCCCAACTGACGACTTAACCTTCGATCAAGCTCCCACCCCTCCCCCAGGTGGTTTTCGTTTTCAGTTTAGGAGATTACGACAGAACAATAATCTAAGAAAACTCGACAAACTGGTTAAAAATCAATCAACAGGACTATAAAGTAATATTATTTTGATTTTCACTTCTAGAAAAGGAACACAGTGGCATAGTGATGCGTAGAAATAAACACATTATTACTATAAACGTAAATGAAATGGAGAGCAAGTTTAAACATGATAAAAGATATATCCACTTAAAAAATTTTAGAATTTTTCCGAAACTTTTATAACTCTCAATCAACTTCTAAAAACACTTAATGTAATATCCGGAAAAAACTGCTCTGAAGGACATCGATATTAGACGCGATATTTTCATTTTATGACGTAAAAACCCAGCAGCTCTGTTAAAAGTAAAGCTTTAGAAATGAAGCATCTCTTTAAATAAAGAAAACTCATTTGGGATAGCTATTTTTTATAACATGGACACATCAAAAGAAATGTCCATAACAATAGAGATGAAAGGTCAAGTAACACAAAAATGTAACGATATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCTCATTGCGACAAACCCTCGACTCTCAGGAAAAGAGAGTGCAATGATTAAGGTTAGTGAAACACAAGAACGGAAAAGAACCCCCAGAAGAATTGATTACTATAAAAATAACACAAAAAGCACAAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAGCTATGAATTCAAAGCCGCAGCGATAATAACCACATCAAACATAAACAAGAAGCAGCTTGAATAAAAAGCAGTAATAAACTAACACAAAGAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTTTAGATATGGGTTAAGTGGAATTAAATGAAATATCAATGCTTGGTGAAGGAGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTCTTAGTTCAAAAAAAGACTTCAATTATTCTCGTAATTAGATAGAAATGTGGAATTATTACTCAGTAATCAAAGATATATGATCAACGCTTTGATGAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACACATATGATGTAATATGTGCAGAATAAACGAATTAGATGAAAAAAGAAAAGATATATCTTACATGGGAAGGGGCAGAATCTCAACCTACCTTAGTAAATTTATGGATGATTTTTTCTTTTTCAGTTGAAAATGGCTGGGGAGGGTGAGATAAATGAAACCGAAAAATAAATGATTATAAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCCTTTACGTCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAGAACAAAGCGAAAACAAACCCTTAGAGCATTTAAAAGCTTTGAGTCTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGTCTAGACAGAATCGTTTTCTGACACGGAAAAGATCGATAATTCAACATTAAATGAGCTTAACATTTCATCATAAACTCATATAATGAAATAGCCATTAACGGAAGCACAAAAAATATCTTTCTTTATCATACGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATCATTGCTCACGATATCAAGAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAGAACAAGAATCTGTATTACATCGACAGATCCTGATTACGCTTGCAAATAATCGGAAAGAAAGCAAAAGTTCAGGTTTGGTTTGTAATAAGGAGTCAGATCGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTACTTCAGTGAGATAAAAGAATTTATATCAAAAGTATGAAACAACTCCACCTACAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCGTAATTAGCGCACCGCTGGCTTGCGCTGAACGCGATTCTGACGCGAACACCGCAAAAGAAGTGTTTTACCCGGGAAAACAGGGAAGGATCACGTCAGGATCGTTTTCAGCTCGCTACGCATAGCTATGCAACAAGCAATGGTGATCACTTTGGGAGCTTACAGTGTTCGTCTGTTTTCGACAGTTTTCTCTCCGAGGAGCTAATCACCGCGTCTGGATAAACAGGGCACGGTGATACTCCGTAATAGCGATCTTTCTTTTTCCTGTACAACACGCTTGCCGTCGATAAAGAGTTTTTCTGCTTAACGCCCCAGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGGAGTTAACTTTCTTACCGAAGAGCTGCCGCCCGTAAAAACGGAAACGGTCTTGCCGCATTCAGCAACCCCTTTTCTGATTTTCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCAACTGATAACCGCCTGCGTATTACTTCCACTTCGTTTGTCGCAAAACATGGCTCGTATCTGACACTTGCTTGTAGGTGTCAGGGCAAAGAAACCCCTGACCAGAACGAATGTAATAGCGTGTGTGCGCGTTGCCATAGCCGCACATCTAATCAGCAAACTCGATACCGACAAAGAGCACGGCGGATTTTGGCGGTGACAGTGTTGTCTGACAAATACCGTCAAAAAGCCAAGCGGCAAACAACGGCTTATCCGCCGGTCGAAAAGTGGTACGCGGTGATATATAATGCACAACACGAGATGACAGACAAGACGGAGAAAGCGAAAAAGATGAACAAGCAACGGCAAATGACGCTCAACATGGCAGGGTTCGCAAGAGATCAGAGCCTGACGCTGCTCGAAAAACTGGACGCACCGGTGACGAACAGGCTTTGTTGTGTGGAAGCTTCACTTTTTTGAACTCATGAAGAACTCAGAACAGCATCAGACACGCGCTTTGATAGAAAAAATAGCACAGAGAGATAACGCTCAGGACAGGATGCCGAACAGCTAACCAGACGTAAGGAGAAAATGTCTGCAAGGCATCTTCGCCTCAGCTCACTGACTCGCTACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCGAAAACACTCAAAGCGGTAATACGGTTTATCCACAAATCCGGGGGATAAAGTCGAGGAAGAACATGTGAGCAAAAAACCAAGCACCGGAGAAAGCCAACGCGGGCGTTTTCCCATAGGCTCCGCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCCAGAAATTTGGCGAAACCCGACTGGGACTATAAAATGCAGGTGTTTCCCCTGGAAGCTCCCTCCGCTCTCCTGTTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCGTAGGCTGTCTTATACACATCTGACGCTACCGACGACAGGGGGTGCGCGCGCAACAATACAAA
+
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@04a11cd4-a588-4369-a396-ffe54819e518
GTAATACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCAGCAGCGCGTCAGATGTAATATAAAGAGAACAGGTCGTTCGACTGCGGCGAGCGGTGTCAGCTCGCTCAAAAGCATTAATACGATTATCCACAGAATCGGGGATAAAGTCGGAAAGAACATGTGAGCAAAGCAAAGCACCGGAGGAAACCAGCGCCGCAGACGTTTGCACCCATAGGCTCCGCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCAGAGGTAAGCGAAACCCGACAGGACTATAAAGAGATACCAGGTGTTTCCTGAGCTCCCTCGTGCGCTCTCTGTTCGACCCTGCCGCTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCTGGCGCTTTCTCGTAGCTCACGCTGCTTGGGTATCTCGGTTCGGTGTAGATCGTTCCTCCAAGCTGGGCTGTGTGCACGAACCCCAGATCAGCCGAAACCGCTGCGCCTTGTCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACAAAGCGCCACTGGCGGCAGCCATTGGTAAAAGTCGAGTGTGCGAGAGGTCAAGAAGTACTTGAAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTCCCAACTGACTTAACCTTCGATCAAACCACCTCCCCAGGTGGTTTTCGTTATTTCAGTTTAGGGAGATTGACCAGAACACAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAGAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATCACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACATGATAAAGAGATATCATAAAAATTTTAAGTGTTTCCGAAACATAACTCTCAGAGCAACTAAAAACACTTAATGTAATATCCGGAAAAAACAACTTTAGGAAAACATCGTTTGATATTAGACGCGATATTTTCATTTTATGACGTAAAAAACCCAGCAGCTCTGTTAAAGTAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTGGGATAGCTATTTTTATAACATGGACACATCCAAAGAAAATGTCCATAACAATAGAGATGAAAGGTCAAGTAACACAAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCTCAGGAAAAGGGAATGTTTTAATGATTAAGGTTAGTAGAAACACAGAACGGAAAAAGAAGAACCCCCAGAAGGGTGATTACTATAAAATAACACAAAAGCACAAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAGCTATATGAATTCAAAGCCACCCAGCGATAATAACCACATCAAGAAACATAAACAAAGAAACAACGATAAAAAACGTATCAAAACTACTAACACAAAAAAGAAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAACCCAGCAGATCAAAACAAAGAGATTTTTAGATATAGGACTAAGTGAATTCAAATGAAATATCAATGCTTGGTGAAGGAGTAAGCAGGCGCTGTCTTTCATTAGCTCAATCTTAGTTTAAAGACTCAATTATTCTCATTGATGAGATGAAAATGGAATTCATTACTCAGTAATCAAAGATATAAGTCAGCACTTTGATAGAAGCAGCAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAAGATGAAAAAAGAAAAAGATATATCTTACATAAGACTAGGAAGAACAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTCTTTTCAGTTAGAAAATGGCTGAGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGTCATTTTCGTTGAGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAAATGGAAGGAAACTAAAACAAACCCTTACAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATGTTTCTGACACGGAAAGATCGATAATTCAACATTAAATAGGCTTAACATTTCATCACCAAGCTCGCATAATGAAATATTGCGTAACGGAAGCACAAAAATATCTTCTTTATCATGCCAGGAAAAAACAAAGAATAGCGCAATAGAAGATCTAATCATTGCTCACGCGTAATAAGAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTGCAAATAATGAAAAGAAAGCAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCAGTGAGATAAAAGAATTTATATCAAAAGTATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACGAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACGCAAAAGAGATGTTTTACCCCGGGAAAACAGGAAGGATGCGTCGAGATCGTTTTCAGCGCTCACTGTAGCTATGCATGAAAGCGAATGGTGATCAGCACGGGAGCTTACGTTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCTGATCAGCACCTCCGCATACTCCCTGTCCCCGACGCTTGCCGTCGATGATTTTCTGTAACGCCCCCAGTCCTCATAACTTCTTTCTGTACCCGATCATCAGTCAGTGGGGTTAACTTTCTTACCGAGAGCTGCCGCCCCGTAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCGCTTTTCTGATTTCCTGGTCTTCTTCTGCCGTCAGATGAACAGGGCAGGCTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCATAAAACATGGCTCCGTATCTGACATGGTGTCGGGGCGAAAGCCCTGATAGGGCAATTGTAATAGCGTGCATGTATGCGCGGTATAACAATTGCACATCCTGTCCTGTCAGCAAGCTCGAATTACCGACGAGAACTGCGGCAGTTTTTTGGCAGTGACAGTGTTGTCTGACAGAAATGCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAGCAAAACAGTCGAAAAAGTGGTACGCGATATAATCACACCTGCATCTCGCCCCCTTACACATCTGACGCTGCCGACGACAGAGTGCGCGCGCAACAATACGTAAC
+
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@e9a5006a-0d10-4fdf-a9d8-333f3c716700
CGTTGTACTTCGTTCAGTTACGTATTGCTACGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATATTATAAGAGACAGTGATACTCCGTAATAGCGATCAGCACCTCCGCATACTCCCTGTCCCGACACGCTTGCCGTCGATAAAGAGTTTTTTCTGTAACGCCCCAGTCCTCGCCAACTTCTTTCGGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCGAGAGCTGCCGCCCGTAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTTCTGATTTCCTGGTCGCTATTATAACACCGTCAGACGAACAGGGCACGACTGATAACGCCGCCTGCGCAGTATTATATCCCACTTCGTTTGTCGCCAAACATGGCTCCATGCTATCTGACACATGGGTGTCCAGGGCAAAGCCCGACCAGGGCAGTGTAATAGCGTGCATGTATGCGCGAGGCATAACAATTGCACATCCTACTCTGTCAGCAAGCTCGAATTACCGACAAAGGCACGGCAGTTTTTGGCAGTGACTTAGTGTTGTCTGACAGAAATGCCCGTCAAAAGCCAAGCGGCAGAATAACGGCAACAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACAGAACGGAGAAAAACGAAAAAGATGAACGAACGCGGCAGCAAGCCGGCGATCAACATGGCGGGATTCGCCAAAAAGTCAGAGCCTGACGCTGCTCGAAAAACTGGACGCACCGATGCTGACGAACGGGCTGCCGTATTGAAGCTGCACGAACTCGCAGAAGAACTCCAGAACAGCATCCAGACACGCTTTGAAGTAGAAAATAGCACGGAGAGATAACGCTCAGGACAAGGATGCCGAACAGCACAACAGAGCGTAAGGAAAATGTCACATAAGGCGCTCTTCGCTTCCTCGCTCGCGACTCGCTACGCTCGGTCGTTCGACTGCGGCAGAGGCGGTGTGGCTTCACTCAAAGCGGTAATACGGTTATCCACAGAATCAGCAGGATAAAGTCGGAAAGAACATGTGAGCAAAAAGAAGCAAAGCACCGGAGGAAGCCAGCGCCGCAGGCGCGTTTGCCATAGGCTCCGCCCCCTGACGAAACATCACAAAAATCGACGCTCAAGCCAGAGGTGGCGAAACCCGACAGGACTATAAAGATGTGCAGGTGTTTCCCCCTGGGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCCGGTTCGGTGTAGGTCGTTCGCTCAAGCTGGGCGCTATTGTGCACGAACCCCGTTCAGCCCGACTAACTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAGAGACACGACCAAAGCGCCACTGGCGGCAGCCATTGGTAAAAGTCGATGTGCAGGAGTTCAAGAGAGTACTTGAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAGACAGGATTACCTGGTTAAGCAGTTCCCCAGCGGCAACCTTCGATCAAACCACCTCCCCAGGTGGTTTTCGTTTTCAGTTTGGGAGATTACGACCAGAACACAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCAAACAGGACTATAAAAATATTATTTGATTATACTTCTAAGAAAAGAAACAGTGGCATAGTGATGCATAGAACAAACACATTATTACTATGTAAACGTAAACAGAATGGAGAGCAAGTTTAAACATGATAAAGATATCACTTAAAAAATTTTTAAAGTGTACAAGAGAAACATAACTCTCAAACAACTAAAAAACACTTAATGTAATATCCGGAAAAAACAACTTTGGGAAAACATCGATAGACGCGATATTTTCATTTTATGACGTAAAAAACCCAGCAGCTCTGTTAAAAAAGTAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTTGGGATAGCTATTTTATAACATGGACACATCAAAGAAATGTCCATAACAATAAGAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACACAAAGTAGTCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAAGGATGTTTTAATGATTAAGGTTAATTGAAACACAAGAACGGAAGAACCCCCAAGAAGAATTGTTACTATAAAATAACACAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAGAATTAAAGCTATATGAGATTCAAAACCGCAGCGATAACCACATCAAGAAACACTAAACAAAAACGGCAACGATAAAAAAACGTATCAAAACTACTAACACAAAAAGAAAAGATGAAATAATAGGCAACCTAAAAAGAGATAGATAATAGAATTAACGTGTTGCAATAATAGCAACAGATCAAAACAAAGAAGTTTTAGATATGGGACTAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGAGGTAAGCAAACGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTATAGTAATCAAAGATATAATCAACGCTTTGATAAAAACAGCAAAAACCAATAATAATCAAATATTTACAGCAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAAAAGAAAAAGTGCATATCTTACATAAGACTGGGAAGAACAAGGAATCTCTCAAAAACCTACAGCAGACGTATTAGTTTAACATGGATGATTTTTCTTTTTCAGTTGAAAATGGCTGTAGGATGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGATCATTTTCGTTGAGGAATTGATGATGAGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAGTGTATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAAGAGCATTTAAAAAAGCATAGAGTCTTTTAATGAAAAGGAAAGTATATTATACTTAATCATCGATGCCGACGAATCGTTTCTGACACGGAAAGATCCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCACACAATGAAATAGCCATTGACGAAGCACAAAAATATCTTTCTTTATCATGCCCGGGAAAAAACAAAGAATGGCGCAATGAAGATCACAATGTTGCTCACGCGTGTAAGAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTTTGCTTCAGTGAGATAAAAAAAATTTATATCAAAAATATGAAACAACTCACCTACAAAATCACTTAGCGCAATGACTAAAGACAGTTACTCGTTTAACATAATGCTGTGGTGTACGCACCGCTGAAGCTTAACGCTGAACGCGATTCTGACGCAGACACCGCAAAGAATGTTTACGGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATATATGCATGAAAGCGAATGGTGATCGCCTGGGAGCTTACGATTGTTCATACCGTCTGTTTTCGACAGTTTTTCTCTCCGGGAAGCTAATCTGCCATAGTCTGGATAACAGGGCACGGTGATACTCCTGTCTCTTATACACATCTCCGAGCCCACGAGACCAGAGAGTGCGCGCGCAGCAATTACGTAAC
+
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@162b5056-1cc5-40d8-a1de-6bebe548bc27
GTTGTACTTCGTTCAATTTCAATGTTGCTGCGCGCGCACTTTCGGCAGCGTCAGATCTATTATAAGAGACGGGTGTGCAGGTCGTTCGCTCAAGCTGGGCTGTGTGCACAAAACCCCACGTTCGGCCACTGACGCGCCGCCCATCCGGTAACATCGTCTTGAGTCCAACCCGGTAAGACACGACAAGCGCCACTGGCGATAGCCATTGGTAAAAGTCGATGTGCGAAGTTCAAGAGTACCGAAGTGATGGCCTGACTACAGCTACACTGAAAGGATGGTTTTGGTGACTCGTCTCGCACAAGACGTTTTCCGGATTAAGCAGTTCAACCCGACTTAACCTTCGATCAGCTCCCAGGTGGTTTTTCGTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAAAGAAGAAACTCAAACAAACTGGTTCAAAATCAATCCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATATTATTACTATGTAAACGTAAACAGAAATGGAAGGCAAGTTTAAACATGATAAAGATATCCATACAAAAATTTTAAGTGTTTCGAGTATAACTCTCAAACAATAAACATAATGTAATATCCGGAAAAAACAACTTTGGGAAAACATCGATATTAGACGCGATATTTCATTTTATGACGTAAAAACCCAGCAGCTCTGTTAAGTAAAAGCTTTGAAATGACATCTTTTGCAAATAAAGAAAACTCATTTGGGATAGCTATTTTTTATAACATGGACATCAAAGAAATGTCCATAACAATGAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACAAAATTAGATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAAACCCTCGGCTCTCAGGGAAAAGGGGAATGTTTTAATGATTAAGGTTAGTGGAAACACAGAACGGAAAAGAACCCCCAGAAGAATTGATTACTATAAAAATAACACAAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAGGTAAGCTATCAGATTCAAAGAACCAAGCGATAATAACAAATAAAAATATAAACAAAACAACGATAAAACAGTATGCAAACTACCTATACAAAAGAAAGATGAAATAATGGGCAACCTAAAAGAATAGATAATAGAATTAACGATGTTTGCAATAACATATGAGATCAAAACAAAGAGATTTTTTTAGATATGGGACTAAATGAATTAAATGAAATATCAATGCTTGGTGAAGGAAGTAAGCAGAGCGCTGTCTTTCCGGTAGCTCAATCTTAGTTCAAAGACAATTATTCTCATTGATGGAGATAGAAAATGGAATTCATTACCAGTAAGTAAAAGATATGATCAACGCTTTGATACAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACACAGCCATGATGTAATATGTGCGATAATATGAGGTAGATGAAAAAAGAAAGATATATCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAAAACCTACAATGCAATTTAACATGGATGATTTTTCTTTTTCAGTTGAAAATGGCTGGGGAGGTGAGATAAAATGAAACCGAAAAAGTAAATGATTATAAAAGTCATTTTCGTTGAGGTGATGATGATTTTCACTTCCCTTACCAATCTACTTGAAATAGAAGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAAACATGAAGTCTTTTAATGAAAAAGAAGAATATATTCTTAATCATCGGTATTATTAGTCGTTTTCTGACATGGAAAGATCGATAATTTCAACATTAAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGAAACTCGCCATTAGCAGGCTTACAAAATATCTTTCTCTATGTTCAGGAAAAAACAAAGAAGATGGCGCAATGAATCTATCATTACTCACGCGTATGGAAGGGTGTTTAGATATATGACTAGATGCTATTCAATAAAATAAAAGAACAAGAATCTAAACGTACATCCATATAGATCTGATTACGCTTGCAAATAATGAAAAGAAAGCAAAGGTTCAGTTTACACCTTAGTTGTGGCAGGGAATCAGATTCTAGAATAGGCACTATCAATGAAGAACAGAAACCATTGATGCGGCGATGGCGCTAGCTAAATGAATAGCGCGAATTATATCAAAAATATGAAACAACTCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATATATGCTCTTAATTACTTGCACGCTGAAACGCGCTGAACGCGCGATTCTGACCGCAGGCACGCAAAAGAAGTGTGTTTTACCCCGGGAAGCAGGAGAGGGATGCAATCTTTGCAGGATCGTTTTCCATTTTGCCCGCTAGCTATGCATGAAAGCGATGGTGTGATCACCGGGGAGCTTACGGTGTTGTCCACCGTCTGTTTCGACAAGTTTTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAGCAGGGCACAGGTGATACCGGCAGCGATCGCTTCCTCCACGCCTCCTGTCCCCGACACGCGCCGTCGATGAAGTTTTTTCTGCCGGCACCCCGATCCTGTAACACCATTGATCAT
+
%$%0244468>;2*$%$'''##$$&&*0/*1&&'*()$#$&&/*-+-)5442,-+$$%$$,1<34)554?&+5.//&*()97@BGFC6A'425.:87.:/./&'*&$#%#%&)(---%?<E)9%&$$&',.%0.&0%&%(%%4%%<&+,()&%.25<A,,-+:%%A12132-/:..+.2'??CC==/5<3<%22355''24247<<A<@@BC932<@?<A/)1.*($0*-/$%'&*/(((*%&,3-+5)+///<A>ADB3LCGHD<::?884(.**#&48A:-02335990'2%17=9<6643)%%(%%#%%*$*'(,%-//532$$$'%'%%%&787:7//'&,)%*/4&+'$07<59<@D<.77>6('878)%0*,%7>ACD>C7B?>;=@92>@>A:1?:8@>$3.1&(>?<,;&'6;;=A;;.087$9<D>8AAD'';>>.0,6=B@EFE@B23:>A@G?B2>:8-&%)06047;CB?@<<1<'65+.=(=,3>0A@<FCBD=B@B<>:79:917:($,()+&('%)%$$&)-+-'(-1<320237324$($/:2255;&%)+'-,*))*,.*;=B--4$$$'//.(53>>>67:DC789,)%&)32'')201<>>95*(&&)%)*(79;86%'.*++7;;:A>EGF<+,>?@A28@@D>7699=8:>:<=004<8=6DDBC@C?<ABD5(33;2/478:4)76.3+./*9-:91741/,4151+,&&&'%%-1*+'**''''((%'01.,23/'71;D?B>>>>>59>;/).5>;?>KB=854--/+1+)86,%9IG9',.:77//?*A<=>>>7%&3A=:=H/471,4(0.6<8846,ABCIG@88-5//+)*-71C8//,65241%$/$$513,.,22@;;<=:7=<<:6/3--72<./21063/;@ABA=98:686=457>?;@<>>;>>>9;;9=%+7:,%:+;6>.'06:.(=<=<=CB>>017=<003@?2-%1$&(/963)B)>BA79;?:((54<?A?00.2+'0/551/+*'18?=>?7:@?<>;96GJA8%->;:?>&><FFDF>>537)4)6::;<9424.*&;<20%98()+-,*,#%%-=6/89,&()&+&''-66A89:*)'$%$$$),-($*%46<9:;239-.7.//.02&+$''(%#$-/08720((+%,-;<0(%5C.':<9COHB<?<%(...32.4065'24B<:8D@77*-'8536'')'*%%=@J8?;;<12(('%'((%5//=?>;4FF3,4==DFLHA>9:4A<+;.5<=-1.2'0++3:<24=:95>;@.(5*)'',,-1262--*+'%)979-45)#5<11<:22012$--.,;+?>=3443/0')+2+%''',%'(&)$$**+1)*/2*8&&,,885369B820.(&&)$.*-)**+('%&&-4610.A@5=;92;:;73004=955'%$*,/+6=BCIJ@47IJE@AA:81??AEAEEB?<=<=;@>6/550788??6127:=818:E:@;@.))%'%%%$$346<513;J@3%,>8))B>8459<;:6620<>EC8849679-((2077'7597*6:FHBA=-6613/&)21:8:57>12:7D=@DGFGTJFCB86=ICA6/4=9441,,7799<379/.0065/8B@88/')*2657701/(()#'37B@>;DC;9990*.,*(9<J<@;B>C633@34-98?BBC?G9=A=@?>@::,&(1/243398982/?=@3381/&>@A>@><9E:EGDI55E?888THB?;8:8A<>5<13@;BEBF;:5JC@=EGDA>119?58C?BEE<EJ<.()/('&)&(67;><<89+&(=60').'((,:=@BBDEFE@D@<79:((*%&')*.*+:<=A@J=)02.4%%*.88'*;:=7=9;?AF.D==D;;>AB9>3$$'''':=E:=@G=5<=,,<13,:8/**695613*1(%%$'01--/'((&(/5551=CE?A==88D@FA<@=6,$%'.)48:?NIC3;=>&--*&+0$-2+,,+$&$%**%'*4-..&(:=;8:/()#$#&')%1865'+7*+1.*&&(''#%$%&&#)/456BAB==AILEDLH&3.-7/0'+*03)'(&'#$)4@55=**%#&(.(---,16352:=<$<45>:),?:<<('&.--%1+.,&651*()6<;3,4)-*0)504*,$$%'%./+49:;959:1)+,,;11)'$$$+444&'),+(%%'&-%20-/1003657#$$$+.-4'('$()&$%)$'',+','+%&##$&'',(4611EHE8.))-./=9=762,0%$%1350*7326297?>EDGF>=>A33B7HGAF>;AD=C>A?40))%$$$%#&-%$%$*-*%%%%$$'/#$(,154/',00/2*)%(%)'/.0+3&/)$+%($'&)#&-<ED4%%$$05,%,68@8/-778/-((*),*;0/$&36882,/#$%$%)00-,6;<9?@JCDE34'())(&$''#$,,(1+?<?C:13--%--%(($&%%$'&%+%$($(1/-.454=?..1-2*$%$&'-/,+.$&##$0338**25:H?<-&8-2C8:-8542,))$)*%',+25?89;@)9%)%*+'&$'$(18=;.&&&#&,&,,.,'6%#$$'(-7;%2**+-','%5<BD@;76,**)'-(/3740*'($.49>=95*$'&)$&%$&$$$%%$$&%%%$$$$(+$$(..:<-'
@e11d9f74-93c9-4f9e-ace8-cd75b3c82854
TAATCATTTGCTCACGCATTAATAAAATTTGAATGTATAGACGATCTATTCAATAAAATAAAAGAACAGAATCTATTACATCATAGATCCTGATTCGCTTACCCAAATAATGAAAAAGAAAGCAAAAGTTCAAGGGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATGCGGCGATGACTGCTTCAGTGAGATAAAAGAATTTATATCAAAATATGAAACAGCTCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACACAAACCCGCGCTGAACGCGATTCTGACGCAGACACCGCAA
+
'%&4878:B3:52,-//$$($%.-('+*.4307/.,*+),00,,0<4?>?@A@8=?8D??CB'4-8/7-;A9<914..3-)8$$&(?$$'87581-./6666:<<@GFAB@B@GC-('555.3IKCA5::7%&&)$4:41%($/,82=23:<@9:28&5.A>B><>=:><?C:55>1BF30A?A>?>I1/2<?@B3:5.04:9:$$#$/98;//==<:<34*2684670<>5%).2159<C<9@=?99>;*2(24,8':(<578-'9>??A:>1197@?@::9432'&&%%0,::<@68?A02:=;?;948>=34==:8777;=51&%,)2)*$*08?>9-7<8+*1=23EGK;;01/C7<98)&'/0+3?@
@4a58265a-1d25-47a1-b851-e7687203734f
TGTTGTGTACTTCGTTCAGTTACGTACTGCGCGCGCGCCTCTCTGGTCTCGTGGGCTCGGAGATGTATAAGAGACAGCTGGATAACTGGGGCACGGTGATACTCCCGTAATGGCGATCCAGCACCTCCGCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCCAGTCTCCATAACTTCTTTCCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCGAGCTGCCGCCCGTAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTCTGATTTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTGTCATAAAACATGGCTCCGTATCTGACATGGGTGTCCGGGGCAAAGCCCTGACCAGAACAGTGTAATAGCGTGCATGTATGCATGGTATAACAATTGCACACATCCTGTCCTGTCAGCAAAAGCTCGAATTACCGACAAAGGCACGGCGGTTTTTGGCAGTGGCTGACGGTGTTGTCTGACAGAAATGCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAACAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACAGAACGGAGAAAACGAAAAGATGAACAAACAGCAGCAAACCGTACTCAACATGGCAGGATTCATAAAAGTCAGAGCCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTACACGAACTCGCAGAGAACTCAGAACAGCATCAGACACGCTTTGAAGTAGAAAATAGCACAGAGAGATAACGCTCAGGACAAGGATGCCGAACGGCACAACAGAGCGTAAGGAGAAAAATGTCACATAAGGCACTCTTCGCTTCCTCGCTCACTGACTCGCTACGCTCGGTCGTTCGACTGCGGCGAGCAGTATCGAAGCTCCTCAAAAGCAGTAATACGGTTATCCACAGAATCAGGGGATAAAGTCGGAAAGAACATGTGAGCAGAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCAGGCGTTTTTCCATAGGCCGCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCAGAGGGTAAGCGAAGCCGACAGGACTATGAGATGCAAGGTGTTTCCCCCTGGAGCTCCCTCGTGCGCTCTCCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCGGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTGCAGGTCCAGCCCGGTAAGACACGACAAGCGCCACTGGCAGCAGCCATTGGTAAAAGTCGATGTGCAGAGAGGTTCAAGAGAGTACCCGAAGTGATGGCCTGACTTCTGGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACGATTACCACCTGGTTAAGCAGTTCCCAACTGGCTTAACCTTCGATCAAACCACCTCCCCCAGATTGGTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAGAAGAAACTCCGACAAACTGGTTAAAATCAATCCAAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTGGAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACATGATAAAAGATATCCACTTAAAAAATTTTAAGTGTTTCGAGAACATAACTCTCAAACAACTAAAAACACTTAATGTAATATCCGGAAAAAACAACTTACGGGGAAAACATCGATATTAGACGCGATATTTTCATTTTATGACGTAAAAAACCCAGCAGCTCTGTTAAAAGTAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAAGCAATTTGGGATAGCTATTTTATAACATGGACACATCAAAGAAATGTCCATAACAATAAAGAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCATCCCTCAATGATGAGTCAATATTCTCAAACACCCTCCCATTTGCGACAAACCCTCGGCTCTCAGAAGAGGGAAAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAAACCCCCCAGAAGAATTGATTACTATAAAAATAACACAAAAAGCACAAAGAAATAAACGGAGAAATAAAACAAACTAAAAGGTAAGCTATATGAATTCAAAACCGCAGCGATAATAACCACATCAAAGAAACGCAAACAAGAAGCAACGATAAAGCGTATCAAAACTACTAACACAAAAAAGAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATAATAGAGATTAACGATATTGCAATAGCAACAGATCAAAACAAAGAGATTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGGAGTAAGCAGAGCGCTGTCTTTCATTAAGCTCAATCTTAGTTCAAAAAGACTCAATTATTCTATATAATTGATGAGATAGAAAATAAATTCATTACTCAGTAATCAAGATATGATCGCTTATTTTGATGAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACAGATTAGATGAAAAAGAAAAGAGATATATCTTATAAGACTGGGAAGAGACAAGGAATCTCAAAAACCTACAACAAATGCAGTTTAACATGGATGATTTTTCTTTTTCAGTTATGAAAATGAGCTGGGAGGTGAGATAAATGAAGGCTCGAGAAAAATAAATGATTATAAAAAGTCATTTTTTCGTTGGGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAGGAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAGAAATATATTCTTAATCATCGTTACCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATGCATTGCTCACGCGTGTAAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAGCAGAATCTGTGTACATCCTTAGATCCTGATTACGCTTGCCAAATAATGAAAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACCAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAGATGTTTTGCAGGAAAGGGAAACCCAGGAGGATCGTCAGGATCGTTTTTTCAGCTCGCTGCTATGTATGCGCTGAAAGCGAATGGTGATCACTTTGGGGAGCTTACGGTGTTCATACTGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACCTGTCTCTTACACATCTCCAAAAGCCCACGAGACCAGAGTTGCGCGCGCAGCAGTACGTAACT
+
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
@67a7d9ec-7322-4ef3-bd72-77f9057efb25
GTTGTACTTCGTTCGAGTTTACGTATTGCTGCGCGCGCACTCTCTGGCGTCAACGGCGTGAATATTATAAGAGGCAATCATTACTCGAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAAAAACAATAATCAAATATTTACAACAACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAAAGAAAAGATATATCTTATAAGACTGGGAAGAAGACAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTCTTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAGCATAGAGTCTTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGGAAATATACATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAAGAATGGCGCAATAGAAGATCTAATCATTGCTCACGCGTGTATCAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAGAACAAGAATCTATTATTACATCCCTTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATTAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCAATTGAATAAAAGGAATTTATATCAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAGTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAGAGATGTTTTACCCCGGGAAAACAGGAAGGTTACGTCAGGATCGTTTCATCGCTGCAACTATACATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGAAGCTAATCTGCCATAAGTCTGGATAACGGAGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCACCCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAAGTTTTTTCTGTAACGCCCCAGTCTCTTAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCGAAGAGCTGCCGCCCGTAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTCTGATTTCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAACCCGCCTGCGCGTATTACTTCCACTTCGTTTGTCATAAACGCTGGCTCCGTATCTGACATGGGTGTCGGGGCAAAGCCTGATGGAACGGTGTAATGGCGTGCATGTATGCGCGGTATAGCAATTTGCACATCCTGTCCTGTCAGCAAGCTCGAATTACCGACAAAGGCACGGCAGGTTTTTGGCAGTGACAGTGTTGTCTGACAGATGCCCGTCAAAAAATGACGGCAGAATAACGGCAACAAAACAGTCGAAAAGTGGTACATGATAGAAATCACACAACGCAGATGACAGACAGAACGGAGAAAACGAAAAGATGAACAAGCAGCAGCAAGCCGTACTCAACATGGCAGGATTCGCAAAAAGTCAGAGCCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAAGCTACACGAACTCATGAAGAACTCCAGAACAGCATCCAGACACGCTTTGGAAGTAGAAAATAGCACAGAGAGATAACGCTCAGGACAGGATGCCGAACGGCACAAGCAAACGTAAGGAGAAAATGTCACATAAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCGCTACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCCAGCTCACTCAAAAGCAGTAATACGGTTATCCACAGAATCGGGGGATAAAGTCGGAAAGGACATGTGAGCAAAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCAGGCGTTTTCCATAGGCTCCGCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCAGAGGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGTGTTTCCCCTGGGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCTTCGGGAAGCGTGGCGCTTTTCTCATGGCTCACGCTGTAGGTATCTCGGTTCGGTGTAGGTCGTTCGCTCAAGCTGGCTAGCTGACCGCACGAACCCCCCGTTCAACCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACAAAGCGCCACTGGCAGCAGCCATTGGTAAAAGTCGATGTGCAAGAGAGTTCAAGAGAGTACTTGAGGTGATGGCCTGACCACAGCTACACTGAAAGGACAGTTTTGGTGACCGTCTCGCACAAGACAGTTACCTGATTAAGCAGTTCCCCAACTGACTTAACCTTCGATCAAACCACCTCCCCAGGTGGTTTTCGTTTTCAGTTTAGGAGATTACGACAGAACACAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGAGCAAGTTTAAACATGATAAAAGATATCCACTTAAAAATTTTTAAGTGTTTCGAAACATAACTCTCAAACAACTAAAAACACTTAATGTAATATCCGGAAAAAACAACTTTGGGAAAACATCGATATTGGAGCGCGATATTTCATTTATGACGTAAAAAAACCAGCAGCTCTGTTAAAGTAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTTTGGGATAGCTATTTTTTATAACATGGACACATCCAAAGAAATGTCCATAACAATAAGAGATGAAGGTCAAGAAGTAACACAAAAATACTCAACTTGATAGATAACACACAAAGTGAATCAGACGTGTCCCTCAATGTTGAGTCAATGTTATCAAACACCCCTCCCATTTGCGACAAACCCTCGGCTCTCAGGAAAAGGGGAGGAAATATTTTGATTAAGGTTAGTGAAACACAGAACGGAAAAAGAACCCCCCAAGAAGAATTGATTACTATAAAAATAACACAAAAAGCACAAAAATAAACGGAGAAATAAAACAAACTAATTAAGCTATGAATTCAAAACCGCAGCGATAATAACCACATCCAAGAAACGCATAAACAAAGAAGCAACGATAAAAAACGTATCAAAACTACTAACACAAAAAGAAAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTTAGATATAGGACTAAGTGGGTAAATGAAATATCAATGCTTGGTGAAGAATAAGCAGAGCGCTTTATCTTTCGATAGCTCAATCTTGGTTAAAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCAGTAATCAAAGATATGATCAACTTTGATAGAAGCAGCAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAACTAGATGAAAAAGAAAAAGATATATCTTACATAAGACTGGGGAAGAGCAAGGGAATCTCCAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTCAGTTGAAAATGGCTGGGAGAGGTGAGATAAATGAAACCGAAAAATAAATGATTATAAAAAGTCATTTTCGTTGGGGAGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAAAGTCTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGAATGGCGCAATGAGATCTCTAATCATTGCTCACGCGTATAAGAAGAGGTGTTTAGATATGCAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCACAATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATGAGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCAATTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGTGACTAAAGATAGTTATAAAATTTAACATAATGCCCTTAATTGTACGCACCGCTGAAAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAGAGATGTTTTGCAGGGAAAACAGGAAGGATGCGTCAGGAATCAGTTTTCAGCTTCGCTGCATAGCTATGCGTGAAAGCGATGGTCACTTTGGGAACTTACGGTGTCGCACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAACTAATCTGCCATAAGTCTGGATACTGTCTCTTGCCACATCTCCGAGCCCACGAGACCAGAGTGCGCGCGCAGCAATGCGTAAC
+
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
@67a7d9ec-7322-4ef3-bd72-77f9057efb25
TCATTACTCGAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAAAAACAATAATCAAATATTTACAACAACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAAAGAAAAGATATATCTTATAAGACTGGGAAGAAGACAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTCTTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAGCATAGAGTCTTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGGAAATATACATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAAGAATGGCGCAATAGAAGATCTAATCATTGCTCACGCGTGTATCAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAGAACAAGAATCTATTATTACATCCCTTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATTAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCAATTGAATAAAAGGAATTTATATCAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAGTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAA
+
5<117BC:4&&8;BDAB>?,*CA86:><D77<$89::>;5&%-234BEA<-);=30*4=47>>=8;=B@<76338;39+-71;=?GBB?>6,&%0':8=>DJ?A56::>53E=44<EDB-&*90-(+-,59<::B5+69;=A233:CDC()&%#2'(.5?C:;:5ABILHGEKJ@C:DBDDFB/./26@CCA@:>@EF@>FLD23@HG0=9<><01FHFA?B:65==./49326<?<>:-6+36>:9B5,EFGA@9:9599BFD>DLB3.(%6<=;>@KA44=/8%=+:<331+,>?=?EG42)$89')'(($++,-5=8'$',--2C:A7A5:-D@=??AD;<E<DD@A8:G@?=====@<895>47.37&C@EGIF>ADHD@<>@.FJ9898:(46423.:;1**'*)(&5;=CCBA4()B??LI;)'&&'%**,<;@?7:BF?CDB7--J;;10B1+-3;<@LLL>>;B15((066977B;<?CA>?BF8=67=8<@?BC;55,889ACD8;DFB51<67<45;>??33:=**5$&$%&$$##1.-0034&*%&#%++46;AFEC9:DCAAIECC<@>77:95305;B>4(455'80<;).48:>?)215**4689?A=>115>B8@=:>2+2)&)&&'(-.2*77ECGKLCA<BDC6A4A@AB;5.@3HK/>EGE?A79,.35%=C9:;.487630:82//',%%%($$')64/99CBB@=?<<778:7788JKHHCF@33D<3'=5F?8KOK<;?AAHABGGOH<A=EHGEJ;ABA<CB8A=5/<>:CCC?.:'74*,-('('?:2AACDBC:6-@@BCHB<9589==>853;46--65201),--4%&%&$&,6GN>,4/;<GGC@F:7=44,5.-+/&65>++99):9=<<GBKOI:0?)726@AHHKDFFA=:;,,61;;<559451=@CFGE:7428;?BA11>%>037>=C7:;,)-..1152(020,*')-;CDF778@?B>=56@9@<@8:FG
@e0998300-6336-4a3d-bb92-51572c44c417
GTTGTACTTCGTTCCGGTTACGTATTGCTGCGCGCGCGCTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAACTTAGGATAACCGTATTACCGCTTTTGAGTGAGCTGACACCGCTCACGCCGCAGTCGAACGACCGAGCGTAGCAGTCAGTGACAGGAAGCGGAAAAGAAGCCCGCCATATGTGACATTTTCTCCTTACGCTCTGTTGTGTCGTTCGGCATCCTGTCCTGAGCGTTATCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGGAGTTCTTCTGCGGGGGACAGTACAGCTTCTCACACATAGCAGCCTGTTCGTCAGCATCAGGTGCGTCCAGTTTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACACTTTTCGACTGTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGCGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAGGGCTTTGCCCCAGGCTTTCACCCATGTCAGATACGGAGCCATGTTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACCGCGAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCGGAGGTGCTGATCGCTATTACGGAGTATCACCGTGCCTGTTATCCAGCTTGTGAGTTAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACATTCATCAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGGCTGAAAACTGATCCTGACGCATCCTTCCTGTTTTCCAGGGTAAAACATCTCTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTCAGCCCGGTGCGTACAATTACAGCGATGTATTAAATTTTATAATTGTCTTTGTCATTGCGCTATGATTTTGTAGAGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGATTTAGATCTTCTATTGCGCCATTCTTGTTTTTTCTGGCATGATAAAGAAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAAATGCTCTAAGGGTTTGTTTAGTTTTGTCTTTCCATTTATTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTTCTCAGTTTCATTTATCTCACCTCCCAGCTTCATTTTTCCAACTGAAAAAGAAAAATCATACCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCGCACTTAAACCCATCGCTGGCTGTGTGTTGTTGTAAATATTTGATTATTATTAGTTTTTTGCTCGCCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTAGACTAAAGATTGGGCTAATAGAAAGACAGCGCTCATAACACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTGTGTTAGTAGTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTAGTTATTATCGCTGCGGTTTTGATTCATATAGCTTACACCTTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGAGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCTTTTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGAGGACACGCTTGATTCACTTTGTGTCAGTATCTATCGTTAGTATTTTTGTGTTACTTCTGACCTTTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATCTTCTTAAAATAACTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAAAGCTTTTACTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAGTTGTTTTCCGGATATTACATTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACATAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTATCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCCACACTGTGCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCTATTCAGTTTCTTCCTTTGATTATTGTATTTCTGAGTGTAATCTCCTAAACTGAAAACGAAAAAACCACCACCGGAATTTGATTTTGATCGAAGGATTAAGTCAGTTGAGGGCTTCTTGGCAGGTAACTGTCTTGTGCGAGACAGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCGCTGCTAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACTGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCCTGTCTCTTATACACATCTGACGCTGCCGACGAAGAGGCGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAGACGCTGATTATCCACAGAATCGGGGATAAAGTCGGAAGAACATGTGAGCAAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCATTTTTCCGCAGGCTCCGCCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGTGTTTCCCCTGGAAGCTCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCGCTTACCGGATACCTGTCCGCCTTTCTCGCTTCGGGAAGCATGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCGGTTCGGTGTAGGTCGTTCGCTCAAGCTGGGCTGTGTGCACGAACCCCGTTCAGCCGACCGCCGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACTGAGTAAGACACGACCAGCGCCACTGGCAGCAGCCATTGGTAAAAGTCGATGTACGAGAGGTTCAAAGTACTTGAAGTGATAAGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTCCCCAACTGACTTAACCTTCGATCAAACCACCTCCCCAGGTGGTTTTCGTTTTCAGTTTAGGAGATTACGACCCGAACACAATAATCACAAGAAGAAACTCCGACAAACTGGTTCAAAATCAATCCAAACAGGACTATAAGTAATAATTATTTTGATTAGCTAGAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACATGATAAAGATATCACTTAAAAATTTTAAGTGTTTCGAGCATAACTCTCAAACAACTAAAAACACTTAATGTAATATCCGGAAAAAACAACTTTGGGAAAACATCGATATTAGACGCGATATTTTCATTTTTATGACGTAAAAAACCCAGCAGCTCTGTTAAAGTAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTGGGATAGCTATTTTTATAACATGGACACATCCAAAGAAATGTCCATAACAATAAGAGATGAAAGGTCAGAAGTAACACAAAAATACAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAGGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAAAAGAACCCCCAGAAGAATTGATTACTATAAAATAACACAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAGGTAAGCATAGCCAGTTCAAAACCGCAGCGATAATAACCACATCAAAAACATAAACAAAGAAGCAACGATAAAAAACAGTATCAAAACTACTAACACAAAAGAAAGATGAAATAATGAGCAACCTAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAGCAACAGATCAAAGTAAAGAGATTTTTTTTTTAGATATAGGACTAAGTGAGATTAAATGAAATATCAATGCTTGGTGAAGGAGTAAGCAGGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCAGTAATCAAGGTGATCAACAACTTCACGATGAAGCAGCAAAAACCAATAATCAAATATTACAACAACACACAGCCATGATGTAATGTGCGATAAACGAATTAAGATGAAAAAGAAGAATATGCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAAACCTACAGCAATGCAATTTGTTGCTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGGAAACCGAAAAATGATTATAAAGTCATTTTCGTTGAGGAGTGATGATGATTTTCACTTCCTTTTTGCAATCTACTTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAATAAATGGAAAGACAAAACTAAAAACAAACCCTTAGAGCATTTAAAAACATAGAGTCTTTTAATGAAAAGAAAGTATATTCGCTCCAATCATCATTACCGACGAATCGTTTTCTGACACGGAAAGATCGATATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAGAATGGCGCAATAGAATCTAATCATTGCTCGCGTGTAAGAAGGAATGTTTAAATATATAGACGATCTAGCTCAATAAAATAAAGAGCAAGAATCTATTATTACATCCAGCAGATCCTGATTACGCTTACCCAAAATAATGAAAAGCAAAGTTCAAGTTTACCTTAGTTGTAATAAGGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCGACAATGCGAAGCGATGACTGCTTCAGTGAGATAAAGAATTTATATCAAAAATATGAAACAACTCCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTATTACCAGACACCGCAAAGAATATTTTGCAGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAGAATCACGGATAACGGGCACGGTGATACTCGTAATAGCGATCAGCACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTGCGAGAGCTGCCGCCCGTAAAAAACCGGAAACAGGGTCTGCCGCATTCAGCAGCCCTTTTTGCGGTTTCCTGGTCGCTATCTGCAAATCCAGACAAACAAGCGATATCACCTGCACTGCTGACCACTTCGCTAAGTTTGATGAAACGACTCCATTATCGTTCGTAGTGTCGAGGGCAAAACCACAGCCGGGAGCAGTTAATGACTGGCGTTGCGTATCACCAGGCGTATGGCTGGTGCGTCTGTCGCGTCGGCGAGCTCCACCGACAAGCGCGAGCACGGCGATGTTTGTGTTAATCTGACAGAAATGCCCGTCAAAAACAACGATCGGCGAAAGATGACATATATAATCACACAACGGTGACAGTGAGGCAGATGAACGAGCGGCGGCGATCGCCTTCAACATGTGTGATTCATGAAAGTCGAGAATTTGTTGCTTTAACCGGCTGGACGCGCCCGACCAACGACGAGCGAACGCGCCATGTGTGAAGCCCGCGGCTTTCTCAGGCAGCATCCGAAAAACGCATCTTTTGAAGTAAGAAAATAACGCAGAAGAAGATTCAACGCTCAGAACAGGATGCGAACATTTTACAACAAGCATGAAGAAAATGTGCATGGAAACTCCCTCGCACTTTCGCACGCTCGATCGTTCATTATATCTCGCTGCACTTTCAAAAAGCAGTAATACGGTATCTGATCTCTTATACACACATCGACGCCCCCCGCCGACATTTATCGCGCGCAACAATACGTGGC
+
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@673d0113-b870-4ab9-936d-43dbc5e80e78
GATATGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATATTGCGATAAGCAGATTAGATGAAAAAGAAAAGATATATCTTACATAAGACTGGAAGGGAACAAGGGAATCTCAAAAACCTACCAAACGATGCAATTTAACATGGATGATTTTTCTTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGGAAACAGAAAAGTAAATGATTATAAAAAGTCATTTTCGTTGGGGGTGATGATGATTTTCCGCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGGAGTCTTTTAATGAAAAAGAAATATATTCTTAATCATCAGTACCGACGAATCGTTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGTTAACATTTCATCCTCAAGCTCGCATAATGAAATAGCCAAAGTAACGGAAGCACAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATCATTGCTCACGCGTGTAAGAAAGAGGTGTTTAGATATATAAACGATCCATTCAATAAAATAAAAAGAATAAGAATCTATTAATACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAATTCAAGTTTACCTTAGTTGTAATAAGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCAACGATGAGTACTGACGATATTTTGCTTCCAGTGAGATAAAAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCACAGTACAGACACCGCAA
+
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
@baab1624-fee9-4f15-9783-feecd3ee5722
CAGTGCCTTCGTTCAGTTACGTATTGCTCGTCAAACAGCGTCAGATGTGTATAAGAGACGGGAAGAGACAAGGAATCTCAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTTCAAGACAGAAAATGGCTGGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGTCATTTTCGTTGAGAGGGTGATGGTGATTTCACTTCCTTTGCAATCTCATGAAATAGAAGAATTAATGATGTTTATCGTGAAAAAACAAATGGAAAGACAAAACTAAAACAGAACCCTTAGAGCATTTAAAAGCATAGAGAGTCTTTTAATGAAAAAAGAAAGTATATTCTTAATCATCGATACCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTTTCTTTATCATGCCAGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATCATTTGCTCACGCGTGTAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCCATGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCAGTGAGATAAAAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGCAATTGTACGCACCGCTGAAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAGAGATGTTGGAAAACAGGAAGGATGCGTCGGGATCGTTTTCTTCGCTGCATATACATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATGATCTGGACTACGGTGATACTCCGTAATCTGTCTCTTATACACATCTCCGAGCCCACGGAGACTGTGAGAGTGCGCGCGCAGCAAATACGTAAC
+
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
@09a10a3e-1c9d-4e95-ad82-12c0624f3230
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCCGCCTCTCCTGGTCTCATGGGCTCGGAGATGTGTATAAGAGACAGAAGCGCTGGGCTGTGTGCACGAACCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTGCAGGTCAACCCGGTAGGGCGACAAGCGCCACTGGCGGCAGCCATTGGTAAAAGTCGATGTGCGAGAGGTTCAGAGAGTACTTGAAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGGCTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTCCCCAACTGACTTAACCTTCGATCAAACCACCTCCCCAGGTGTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACGCAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAAACCAAGTTTAAACATGATAAAGATATCCACTTAAAAAATTTTAAGTGTTTCGAAGAGCATAACTCTCAAACAACTAAAAAGCTTACTTAATGTAATATCCTGAAAAAACAACTTTGGGAAAACATCGATATTAGACACGATATTTCCATTTTATGACGTAAAACCCAGCAGCTCTGTTAAAGTAAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAAGAAAACTCATTTGGGATAGCTATTTACATAACATGGACACATCAAAGAAATGTCCATAACAATAAGAGATGAAGGTCAGAGTAACACAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCTCATTGCGACAAACCCTCGGCTCTCAGGGGAAAAGAGGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAAAGAACCCCCCAGAAGAATTGATTACTATAAAATAACACAAAAGCACAAAGAAATAAACGGAGAAATAAAACAAACTAAAAGGTAAGCTATATGAATTCAAAACCGCAGCGATAATAACCACATCCAAGAAACATAAACAAAGAAACAACGATAAAAAACGTATCAAAACTACTAACACAAAAAAGAAAAGATGAAATATTAGGCAACCTAAAGAATAGATAATAGAATTAACGATATTGCAATAATAACCCAACAGATCAAAACAAAGAGAGATTTTTTTTTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGTGGTGAAGGTAAACAGAGCGCATCTTTCGATAGCTCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAAATTCATTACTCAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACGCACAGCTTCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAGAAAGATATATCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGTCATTTTTCGTTGAGGGTGATGATGATTTCACTTCCTTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAAACAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGGGAAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGAATAGCGCAATAGAAGATCTAATCATTGCTCACGCGTGTAAAAAGAAGAGGTGTTTAGATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCTGGAACAACACCCAAATAATGAAAGAAAGCAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACAGTGAAGCTGCTTCAGTGAGATAAAAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAGAGATGTTTTACCCAGGAAAACGGGAAGGATGCGTCAGGATCGTTTTCAACTCCTTTCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAATTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCCAGCACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCGAGAGCTGCCGCCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTCTGATTTCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCATAAAACATGGCTCCGTATCTGACATGGGTGTCGGAGGCAAAGCCTGACCAGGGCAATTGTAATAGCGTGCATGTATGCGCGGTATAGCAATTACATCCTGTCCTGTCAACAAGCTCGGATTACCGACAAAGGCACGGCAGTTTTGGCAGTGACGGTGTTTGTCTGACCAGAAATGCCGTCAAAAAAGCCAAGCGGCAGAATAACGGCAACAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACAGAACAGGAGAAAACGAAAAGATGAACAAGCAGCAAGCCGTACTCAACATGGCGGGATTCATAAAAGTCAGAGCCTGACGCTGCTCAAAAAAACTGGACACGCGATGCTGACGAACGAAAGGCTGCCATGTGTGAGAAGCTGCACGAACTCGCAGAAGAACTCCAGAACAGCATCAGACACGCTTTGAAGTAGAAAATGGCACAGAGAGATAACGCTCAGGCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAGTGCGCGCGCAGCGGTACGTAACC
+
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
@97804cb9-0ad5-4f2e-abd6-de8c42002abd
GTTACTTCGTTCCGGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCAGCGTCAGATGTATAAGAGACAGGAACATGGCGGGCAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCAGGCGTTTTTCCATAGGCTCCGCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCAGGGTGGCGAAACCCGATGGGACTATAAAAAGATGGTGTTTCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCTTCGGGAAGCGTGGCGCTTTCTCGCAGCTCACGCTGTAGGTATCTCGGTTCGGTGTGAGTCATTTCGCTCAAGCTGGGCTGTGTGCACGAACCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCATGAGTCCAACCCGGTAGGGCTTGCGACAAAGCGCCACTGGCAGCAGCCGATGGTAAAAGTCGATGTGCAGGGAGTTGATGCGGAAGTGATGGCCTGACTACAGCTACACTGAAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGCTCCCCAACTGACTTAACCTTCGATCAAACCACCTCCCCAGGTGGTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAAGGAAGAAACTCCGACAAACTGGTTAAAATCAATCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTGGCATAGTGATGCATAGAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACAGTCAAAGATATCCATAAAAAATTTTAAGTGTTTCGAGAACATAACTCTCAAACAACTAAAAACACTTAATGTAATATCGGAAAAAACAACTTTGGGAAAACATCGATATTAGACGCGATATTTTCATTTTTATGACGTAAAAACCCAGCAGCTCTGTTAAAAGTAAAAAGCTTTGAAAATGAAGCATCTCTTTTAAATAAAAGAAAACTCATTTGGGATAGCTATTTTTATAACATGGACACATCAAAGAAAATGTCATAACAATAAGAGATGAAGGTCAAGTAACACAAAATACTCAACGATAAGATAACACAAAGTGAATCAAAGCGTGTCCACTCATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAAGAGGGAATGTTTAATGATTAGGTTAGTGAAACACAGAACGGAAAAAAGAACCCCCCAGAAGAATTGGTCACTATAAAAATAACACAAAAAGCACAAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAGCTATATGAATTCAAAACCGCAGCGATAATATACATCCAAGAAACATAAACAAAAGAAGCGATAAAACGTATCCATTATAACACAAAAAGAAAACAAATAATAGGCAACCTAAAAGAATGAATGTAAATTAACGATATTGCAATAATAGCAACAGATCAACAAGAGATTTTTTAGATATAGGACTAAATGAATTAAATAGAAATATGTGCTTGGTGAAGGAAGCTAAGCAGAGCGCTTTATCTTGAAGTAGCTCAATCTTAGTTCAAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCAGTAATCAAGATATGATCAACACTTTTGATAGAAGTAGCCTTAAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAGCGAATTAGATGAAAAAGAAAAAGATATATCTTACATAAGACTGGGAAGAGACAAAGAAGTCTCAAAAGCCTACAGCAATGCAATTTAACATGGATGATTTTTTCTTTTTCAGTTAGAAAATGGCGCTGGGAGGTGAGATAAGTGAAACCGAGAAAAATAAATGATTTATAAAAGTCATTTTCGTTGGGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAGCATAGAGTCTTTTAGTAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGGGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCGGAAAAAACAAGAATAGCGCAATAGAAGATCTAATCATTGCTCACGCGTGTAAGAAGAAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAAAGTCTATTATTACATCCTTAGATCCTGAAAGTTAAAAACACCCAAATAATGAAAAGAAAGCAAAGAAGTTCAAGTTTACCTTAGTTGTAATAAGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACTGATGACTTTACTTCAATGAGATAAAAGAATTTATATCAAAAAATATGAAACAACTCCACCTACGAAATCATAAGCCTAATGTTAAAGACAATTATAAAATTTAACATAATGCTGTGGTGTACGCACCACGCTGAAACGCGCTGAACGCGATTTCTGACGCAGACACCGCAAAAGAAGAGATGTTTTACCGGGAAAACAGGAAGGATGCCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCCTTTTGGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACGGATTTTCTCTCCGGGAAACTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAACACCCTCACGCATACTCACAATACCATTACGCTTGCCCAATCGATAAGGGATTTTTCTGTAAGCTTGCCCCAGTCTCATAACTTCTTTCAATTACCCGATCATCAGTCCGTTTGAGTTAACTTTTTCTTACCGAGAGCTGCCGCCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAACAGCCCTTTTTCTGATTTCTGATGCTTCTTCTGCCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTGTCATAAAACATGGCTCCGTATCTGACATGGGTGTGGGGCAGAAGCCCTGACCAGAACGAATGTAATAGCGTGCATGTATGCGCGGTATAACAATTGCACATCCTGTCCTGTCAGCAAGCTCGAATTACCGACAAGGCGCGGCAGTTTTTGGCAGTGACGGTGTTGTCTGACAGGAATGCCGTCAAAAAGCCAAGCGGCAAGAATAACGGCAACAAAACAGTCGAAAAAGTGGTACGCGATATAATCACACAACAAGCACGGATGACAGACAGAACGGGAAAACGGAAAGATGAACAAGCAGCAGCAAGCCGTACTCAACATGGCGGGATTCATAAAGTCAAGAGCCTGAGCGCTGCTCGAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTGCGAACTCGCAGAAGAACTCCAGAGACAGCATCAGACACGCTTTGAGAGTATGGAAAATAGCACAGAGAGATAACGCTCAGGACAGGATGCCGAACGGCACAACAGAGCGTAAGGAAAATGTCACATAAGGCGCTCTCTTCCGCTTTACCTCGCTCACTGACTCCGCGCTACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCAGCTCGCTCAAAAGCGGTAATACGGTTATCCACAGAATCAGGGATAAAGTCGGAAAAAGAACACTGTCTCATATACATCTGACGCTGCGCCGACGACAGAGTGCGCGCCACCAACAATAAATAAC
+
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
@69f7b4da-c6b3-46fe-875c-91a839ad536d
GGTATACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTGTCGTCGGCAGCGTCAGATGTATAAGGCAACATCCAAAAGAAATATCCATAACAATAAGAGATGAAAGGTCAAGTAACACAAAAATCTCAACGATAGATAACTTTCAAAGTGAATCAAGCGATGTCCATAATGTTGAGGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTTCAGGAAAAGGGGAATGTTTTAATGATTAAGGTTAGTGAAACAGAACGGAAGAACCCCCAGAAGAATTGATTACTATAAAATAACACAAAAAGCACAAAAATAAACGGAGAAATAAAACAAACTAAAAAAGGTAAGCTATATGAATTCAAAACCGCAGCGATAACCACATCAAAACATAAACAAAAGCAAACGATAAAAAACGTATCAAAACTACTAACACAAAAGAAAGATGAAATAATAGGCAACCTAAAGAATAGATAATGAATTAACGATATTTTCAATAAACACTTAACGAATCAAAACAAAGAGATTTTTTTAGATATAGGACTAAGTGAATTAAAGCCCAAATATCAATGCTTGGTGGAAGGGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAGAAAAATGGAATTCATTACTCGAAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAGCAAAAAATAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAACTATGTGCGATAAACAATTAGATGAAAAAGAAAAGATATATCTTGCCAGACTGGGAAGAGACAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATTGAAGCCGAGAAAAATAAATGATTATAAAGAAGATCATTTTCGTTGAGGGTGATGATCCTACTTCAACTTTGAAATCTACTTGAAATAGAAGGAATTAGCATGTTTATGTTGAAAAATAAATGGAAAGAATAAAGCCCAAACAAACTCTTAGAGCATTTAAAAACGCGGTCTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATAATTTCCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACTAGCTCATAATAGAAATAATAGTAACAGGCTTACAAAATATCTTTCTTTATCATGCCAAGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATCATTGCTCACGCGATATCAGAAGAGGTGTTTAGATATATAGACGATCTGACTTCAATAAAATAAAAGAACAAGAATCTATTACATCCTTAAGATCCTGATTACGCTTACCAATAATGAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGTTAGAAGAATGAGCATATCAATGAAGAACAAAACCATTGATACCCAATGACGATGACCTTCAGTGAGATAAAGAATTTATATCAAAAATACAAACAACTCCACCTACAAAATCCTTAGCGCAATGACTAGAAGACAATTATAAATTTAACATAATGCTGTAAGTGTACACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAGAGATGTTTTACCCCGGAAAACAGGAAAGGATCGTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTTCGACAGTTTTTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTTACTCCGCAATCTGTCTCTGCCACACATCTCCGAGCCCACGAGACCAGAGAGTGCGCGCGCAGCGATGTGCGTAACTT
+
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
@a108d13b-b0a2-4aed-b543-9f1db323d168
TCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTCTTTTTCAGTTGAAAATGGCTGGGAGGTGAAGTAAATGAAACCGAGAAAAATAAATGATTATAAAAGTCATTTTCAGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTAGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAAACAACCATAAGAAGGCATTTAAAAAGCATAGAGTCTTTTAATGAAGAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTCCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCGCAAGCTCGCATAATGAAATAGCTTCATTAACGGAAGCACAAAGTATCTTCCTTTATCATGCCAGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATCATTGCTCACGCGTGTAAGAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATGCTGACGATGACTTACTTCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACCCAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTAAAAGCGCGCTGAACGCGATTCTGACGCAGACACCGCAA
+
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
@0065039f-a033-444a-afbe-fb5b048eadf4
GTTATGCGCCCCGTTCAGTTACGTATTGCTGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAGAGACAGAGCTCACGCTGTAGGTATCTCGGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCGTTCAGCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACAAAGCGCCACTGGCGGCAGCCATTGGTAAGAATCGATGTGCGAGAGGTTCAAGAGTACTTGAAGTAATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTCCCCAACTGACTTAACCTTCGATCAAACCACCTCCCAGGTGGTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAAGAAGAAACTCCGACAAACTGATTAAAATCAATCCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACATGATAAAGATATCCACTTAAAAATTTTAAGTGTTTCGAAACATAACTCTCAAACAACTAAAAACACTTAATGTAATATCCGGAAAAAACAACTTTGGGAAAACATCGATATTAGACGCGATATTTTCATTTATGACGTAAAAAACCCAGCAGCTCTGTTAAGTAAAAAGCTTTAGGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTTAGGATAGCTATTTTTATAACATGGACATCGAAATGTCCATAACAATAAGAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCCAATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAGGGAATGTTTTAATGATTAAAGTTAGTGGAAACACAGAACAGAAAAAGAACCCCCAGAAGAATTGATTACTATAAAAATAACACAAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAAAGGTAAGCTATATGAATTCAAAACCGCAGCGATAATAACCACATCAAGAAACATAAACAAAGAAGCAACGATAAAACGTATCAAAACTACTAACACAAAAAGAAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAGCAACGGATCAAAACAAAGAGATTTTTAGATATAGGACTAAGTGAATTAAATAAATATATCAATGCTTGGTGAAGGAGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTGAATTCAAAAGAAACTCGAATTATTCTCATTGATGAGATAGAAAATAAGAATTTCATTACTCAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTACGATAAACGAATTAGATGAAAAAAGAAAAGATATATCTTACACAAGACTGGGAAGAGACAAAGGAATCTCAAAAAACTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTTCAGTTGAAAATGGCTGGGAGGGTGAGATAAATGAAACCGAGAAAAGTAAAATGGTGATTATAAAAAGTCATTTTCTGAATTTGAGGGTGATGATGATTTTCCACTTCCTTTGCAATCTACTTGGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAGGGCAAAACTGAAACCAAACCCTTAGAGCATTTAAAAGCATAGAGAGTCTTTTAATGAAAAGAAAGTATATTCATAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCTCGCATAATGAAATAGCCATTAACGACTACAAAAATATCTTTCTTTATCATGCCAGGAAAAAAAAAAACAAGAATGGCGCAATAGAAGATCCCCAATCATTGCTCACACTGGCCAATGTAAGAAAAGAGGTGTTTAGATATAGACGATCTATTCAATAAAATAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATAAATGAAAGAAAGCAAAAGTTCAAGTTACCTTAGTTGTAATAAAGGAATCAGATTCTAGAATGAGCATATCAATGAAGAACAAAACCATTGATGACGATATTTGCTTCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTGAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAGAATGTTTTACGGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCCGGAAGCTAATCTGCCATAAGTCTGGATAACAGGAGCACGAGTGATACTCCCGTAATAGCGATCAACACCTCACCATCTCCTGTCCCCGACGCTTGCCGTCGATAAAGAGTTTTTTCTGTAGCAACACACAGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCGAGCTGCCGCCCGTAAAACCGAAACAGTCTTGCCGCATTCAGCAGCCCTTTTCTGATTTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCATAAAACATGGCTCCGTATCTGACATGGGTGTCGGGGCGAAAGCCCTGATGGGGGCGAATTGTAATAGCGTGCATGTATGCGCGGTATAACAATTGCACATCTGTCCTGTCAGCAAGCTCGAATTACCGACAGAGGCACGGCAGTTTTTGGCAGTGACAGTGTTGTCTGACAGAAATGCCCGTCAAAAAGCCAAGAAGCGGCAGAATAACGGCAGCAAAACAGTCGAAGAAGTGAGTACGCGATATAATCACACAACGCAGATGACAGACAGAACGGAAAACGAAAAAGATGAACAAGCAGCAGCAAGCCGTACTTTTTTAACATGGCGGGATTCATAAAAAGTCAGAGCCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTGCACAGACTCGCAGAAGAACTCCAGAACAGCATCCAGACACGCTTTGAAGTGAAAATAGCGCAGAGATAACGCTCAGGACAGGATGCCGAACGGCACAACAGAGCGTAAGGAGAAAATGTCACATAAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCAACTCACTCAAAAAGCGGTAATACGGTTATCCACAGAATCGGGGGATAAAGTCGGAAAGAACATGTGAGCAAAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCAGGCGTTTTCCTCAGGCTCCGCCCCCTGACGAGCATCCCCACAAAAATCGACGCTCAAGCCAGAGGTAGCGAAACCCGACAAGGACTATAAAGATACCGGGTGTTTCCCCCTGGAAGCTCCCTCATACGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAG
+
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
@1272025f-f488-4ee6-a1e9-b48ea108fce9
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCACTCTCTGGTCTCATTAGGCTCGGAGATGTGTATAAGAGACGGGTCCATAACAATAAGAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACACCATCAACGTGTCCCTCAATGTTGAGTCAATATTATCGATACCCTCCATTGCGACAAACCCTCGGCTCTCGGAAAAGGAAAATGTTTTAATGATTAGGTTAGTGAAACACAGAACGGAAAAAGAACCCCAGAAAAGAATTGAGATTTACTAAAAATAACACAAAAGCACAAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAACTATATGAATTCAAAACCGCAGCGATAATAACCACATCAAGAAACATAAACAAGAAGCAACGATAAAAACGTATCAAAACTACTAACACAAAAAGAAAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATAATAAAATTAACGATATTGCAATAATAGCAACAGATCAAAACAAGAGATTTTTTTTTTTTAAGATATGGGACTAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGGAGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAGACTCAATTATTCTCATTGATGAGATAGAAAAATGGAATTCATTACTGTTAATCAAAGATATGATCAACGCTTTGATAGAAGCAACAAAAACCAATAATAGTAAATATTTACAACACACAGCCATGATGTAATATGTGCGATAAACGAAGATTAGATGAAAAAAGAAAAGATATATCTTACATAAGACTGGGAAGAGACAAGTCTCTCAAAACCTGGCAATGCAATTTAACATGGATGATTTTTCTTTTTCAGTTGAAAATAGCACAGGAGGTGAGATAAATGAAACCGAGAAATAAATATTATAAAAGTCATTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAGAAATATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAAGATCGATAATTTCAACATTAAATGTGACTTAACATTTCATCACCAAGCTCGCATAATGAAATAATAACCTCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGAATGGCCGCAATAGAAGATCTAATCATTGCTCACGCGTGCTCAGAAAGGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAAGAATCTATTATTACATCCTTAGATCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGTTCAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAAGACAAACCATTGATACTGACGATGACTGCTTCAGTGAGATAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATGAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCTGAAAGACGCGATTGACGCAGACACCGCAAAAAGAGATGTTTTACCCCGGGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCACATGGCTATGCATGAAAGCGAATGGTGATGATCACTTTGGGGAGCTTACGGTGTTCATACAATCATTTTCGACTCAGTTTCTCTCCGGGAAGCTAATCTGCCCATAGGTGATCATAGGTACAAAGCAAATCGCGCTATAAGCGGTAGCTGACGCATCCTTCCTGTTTCCCGGGGTAAACATCTCTTTTTGCGGTCTGCGTCAGAATCGCGTTCAACATTATGAAGCCTCTTGCTGATGAACCGTTCTGACACATTCTTTTTATCTCGCAGCTTCCTGTCTGCTATACACATCTCCGAGCCCACGAGACCAGAA
+
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
@1a790921-ff88-4d54-9ce9-a7247e2cfe8d
ATAGACGATCTATTCAATAAAATAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGCAAAGTTCAGGTTTACCTTAACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCGATTACTGACGTATTACTTCAGTGAGATAAAAGAATTTATATCAAAAGCATGAAACAACTCACCTACAATCCTTAGCGCAATGACTAAGAAACAATTATAAAATTTAACATAATGCTGTAATTGTACTGCTAGCGCCGAACATGATTCTGACGCGAACACCGCAA
+
7,*2.8/)&9)DDFD<<8@CGH?BI(8><;8=&6D;@CDDG<DD=>>89A:?6BE66;6B@@A;D5331((++,.74339<821..=BC03E?>:=>DEB>+2+,#&##%.)9/55+49<9:0;67-<=6=<>3.453A:?8ABCE>9>@C>FB'&%=7?><()&$$$.975A?*$,##%*669<57:=8&?9=>B%*+47;80.+*656.*%#+,/12.801>-(267A@516((2(+.;:;=BCABB8)%%$,,4>@@?A49>A<A:DCCBA68:B=.&5,&2347<9(().0+'$//3532.+((*)*3%)03B60$$-1?8?386:
@e0d24d77-3c4a-4d1e-b468-3fbcd00db488
TATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCAGTGAGATAAAAGAATTTGCATCAAAAATATGGAAACAACTCCGCCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACACTTTCCGCTGAAACTGAACGCGGTCTGGCGCGAACACCGCAA
+
A3-C>@>?=;-::<ADC6@A9:==<91-&%)/412--,.$&')-(3440+=557/&%/.+,-%%&%(>?26C?@>)++-13))890/5==FDC;=?959.(%'+*478?A>::?@3>EFIG?E;:220.360:;:@<?C?>=753+++.4(/6(%%'(#&&$$'())%%-*/2),%()0)()'$)&&,98BC87IK
@4934e552-bdf7-4cc5-9559-ac73476348f4
AATAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGCAAAAGTTCAAGTTTACCTTGGATTGTAATAAGGAATCAGATTCTAGAATAAGAGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTTTCTTCAGTGAGATAAAGATTTATATCAAAATATGAAACAACTCCACCTACAAAATCACAAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTAAAACACTTGCTGAACGCGATTCTGACGCAGACACCGCAA
+
=C7::<00'.9'(.2?32+%.-&*.+:>22;39@BB565*00B;+.)%%15278;?H3<=>98;++,.BC<4<@CE=?>HH6-*+79%+$04$(5:;<C6<8?8BCB??BA=76@C8$%&%5;;HC>A8:7<=E8=B9??AD88;>=86=8''4''/00.0++/.$%*'*$-'&''$1/&(2AC@DD@:<HIB90+16)@6;+,=;58>DBD3;77-&$%#'$%'*/9;=DCA@7GN;4C@<?<?B@FI5IFHHFA80/AFHI;;;CGJENB69BGIDC6/-/57;2-(%%%((+--65--0/3576:5;0/*/'*-37:=KM
@8fbd6bd9-6afa-4d0c-af3d-0b6dde99d70e
GTCGGTGTACTTCGTTCAGTTGCGTATTGCTGCGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATTAATATAAGAGACAGACGTAGCGGGATTCATAAAAAGTCAGGCTGGCCTTTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGGGCTGCACGAACTCATGAAGAACTCCAGAACAGCATCAGACACGCTTTGAAGTAGAAAATAGCACAGAGAGATAACGCTCAGGACAGGATTGAACGGCCTAACCGGGCAATAAGGAGAAAATGTCACATAAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCACTCACATCGGTCGTTCGACTGCGGCGAGCGGTGTCAGCTCACTCAAAAGCGGTAATACGGTTATCCACAGAATCGGGGGATAAAGTCGGAAAGAACATGTGAGCCAAAAAGCAAAGCACGGAGAAGCCAGCGCCGCGGGCGGTGCGCATAGGCTCCGCCCCTGACGAGCATCACAAAAATCGACGCTCAAACCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAAGGTGACTTTCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCTTCGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCAGCCAACTGGGCTGTGTGCGAACCCCGTTCAGCCGACCGCCGCGCGCTTAATCAGTAACATCGTCGCGGGTCCAACCCGGTAAGACACGATAAAAGCGCCACTGGCAGCAGCGGTGGCAAAGTCGATGTGCGAGAGGTTCAAAGAGAGTACTTGAAGTGATGGCGGCTTCCAGCTACTGAAAGGACAGTTTAGTGACTCGTCTCGCGCACAAGACAGTTACCTGGTTAAACGGTTCCCAACAGTAACCTTCGATCAAACCACCTCCCCGGGTGGTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAGAAGAAACTCCGACAAACTGGTTAAAATCAATCAAACAGGACTATATAAGTAATGTATTTTAGTTATACTTCTAGAAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACATGATAAAAAGATATCCACTTAAAATTTTAAGTGTTTCGAAACATAACTCTCAAACAACTAAAAACACTTAATGTAATATCCGGAAAAAACAACTTTGGGGAAAACATCGATATTAGACGCGATATTTTCATTTTATGACGTAAAAAACCCAACTCTGTTAAAGTAAAGCTTTGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTTGGATCAGCTATTTTTATAACATGGACACATCAAAAATATCCATAACAATAAGAGATGAAAGGTCAGGTAACACAAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCATTAATCCCTCAATGTTAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCCTCGCTCTCGGAAAAGGATGTTTAATGATTAAGGTTAATTGAAACACAGAACGGAAAAAGAACCCCCAGAAGAATTGATTACTATAAAAATAACACAAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGGTAAAGCTATAGATTCAAACCGCAGCGAAATATTCACATCAAAACATAGGCAAAGGAAACCCAACCGATAAAACGTATCAAAACTGCTAACACAAAGATGGAATAATGAGCCTAAAGAGATAGATAATGAATTAACGATGTGTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGGAGTAGGCAGGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAGACTCAATTATTCATTGATGAGATAGAAAATGGAATTCATTACTCAGTAATCAAGATATGATCAACGCTTTGATAGAAACAGCAAAAACAATAATAATCAAATATTTACAACAACACACACAGCCATGATGTAATATGTGCGATAAACAGATTAGATGAAAAGAAAGATATCACACATGGACTGGGAAGAGACAAGGAGTCTCAAAACCTACAACAATGCAATTTAACATGGATGATTTTTCTTTTTCAGTTGAAAATGGCTAGGAGGTGAGATAAATGAAACCAAAGAAAAATAAATGATTATAAAAGTCATTTTTCGTTGAGGGTGATGATGATTTTCCACTTCCTTTGCAATCTACTTGAAATAGAAGGGAATTAATGATGTTTATGTTGAAAAATAAATGAAGAATAAACAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAAGAAAATACTATTAATGTCGATGCCATTGAATCGTTTTCTGACACGGAAAGATCGATGAATTTCAGCATTAAATGAGCAACATTTCATCGCAAGCTCGCATAATGGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAAACAAAAAGATGGCGCAATAAGAGATCAATCGTTGCTCACGCGTATAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTGTCTTAGATCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAGAGTTCAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACACGACATTGTTCCTTCAGTGAGATAAAAGAATTTATATCAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTGCAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACCGCGCTGAACGCAGTTCTGACGCAGACACCGCAAAAGAGATGTTTACCCCGGAAGCGGGAAGGATGCGTCGGTCGTTTTCAGCTCGCTGCATATGCATGAAAGCAGATGGTGATCACTTTGGGAGCTTACGATTGTTCATACCGTCTGTTTTCGACAGTTCTCCCAGGAAGCTAATCTGCCGCAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCATGATCAGCACCTCCGCCTACTCCCTGTCCCCGACACGCTTGCCGTCGATAAGGTTTTTCTGTAACGCCGGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGGTTCCGCTTTCTTACCGAGAGCTGCCGCCGTAAAACCGAAACAGTCTTGCCGCATTCAGCCCTTTTTCTGAGTTCCTGGTCTTCGCCTGCCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTACACCCCCTTCGTTTTAGACAATACATCAGC
+
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
@bb08edb4-ba83-4876-a500-c9ceff05b7a8
GATGTACTTCGTTCCGGTTACGTATTGCTGCGCGCACTCTCTGGTCGTGGGCTCCGGAATGTAACATAGGGCGATAGTGAAACACAGAACGGAAAAAGAACCCCAGGAAAATTGATTGTAAATAACACAAAAAAGCACAAGAAATAAACGGAAAATAAAACAAGCTAAAAGGTAAGCTATATGAATTCAAAACCGCGTGATAATAACCACATCAAAAACACAAACAAAACTTCAACGATAAAAAACGTATCAAAACTACTAACACAAAAGAAAAAGATGAAATAATAGGCAACCTAAAAGAATAGATAATAGAATTAACGATAATGTACATTAATAGCAACAGATCAAAACAAGAGATTTTTTTAGATATGGGACTAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGAGTAAACATGAGCACTGTCTTTCATTAGCTCAATCTTAGTTCAAAAAGACTCAATTATTCTCATTTGATGAGATAGAAAATGGAATTCATTGCTCAGTGATAAAGATATGATCCAACTTTGCTTTATTAGAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAAAGAAAAGATATATCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTCAGTTGAAAATGGCTACAGGAGGAATTTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAGAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGAATTAATGATGTTTATGTTGAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAGCCAGAAAGAAAGTACTCATTCTTAACATATCATCGATGCCGACGAATCGTTTTCTGACACACGGAAAAGATCGATAATTTCAACATTAAATAGACTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATGTACCGGGAAAAAACAAGAATGGCGCAATAGAATCACAATCATTGCTCACGCGTGTAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTTGCTTACCAAATAATAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACGGCGATGAAACTGCTTCAGTGAGATAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCGCGCAATGACTAAAGACAATTCGCGGAATTTAACGCATAATGCTGTAATTGCTGCTACAAACAACGCTGAACGCGATTCTAACAGACACCGCAAAGAGATGTTTACCCCGGGAAAACAGGAAGGATGTCAGGATCGTTTTCAGCTCACTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACAGGGCCTGGTGATACTCCGTAATAGCGATCAACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTCTGTAACGCCCCAGTCTCATAACTTCTTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCCACCGAGAGCTGCCGCCCGTAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTTCTGATTTCCTGGTCTTCTTCTGCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCGAACTTCGTTTGTCATAAAACGAAACCCGTATCTGGCTTGTAGGTGTCGAAAGGGCAAGCCCTGACCAGGGCGATGTAATAGCGTGCATGTATGCGCGTATAACAGTGCACATCCTGTTATCTGTCAGCAAGCTCGAATTACCGACAAAGGCGACGGTTTTTGGCGGTGACAGTGTTGTCACGATACCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAGCAAAACAGTCGAAAAGTGGTACGCGATGCCAATCACACAACGCAGATGACAGACAGAACGGAGAAAACGAAAAGATGAACAAGCAGCAGCAGCAAGCCGTACTCAACATAGCCGGGATTCATAAAAGTCAGAGCCTGACGCTGCTCAGCTATGGACACCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTGCACGAACTCGCAGAAGAACTCCAGAACCCAGCATCAGACACGCTTTGAAGTAAATAGCACAGAATAACGCTCAGGACAGGATGCCGAACGGCACAACAGAGCGTAAGGAGAAAATGTCACATAAGGCGCTCTTCCCGCTTCCTCGCTCACTGACTCGCTACGCGCTCCGGTCGTTCGACTGCGGCGAGCGGTGGTCAACTCACTCAAAAGCGGTAATACGGTTATCACAGCAATACGTAACT
+
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
@f094b478-981b-4753-bcef-d1e48be0214d
TATATAACGATCTATTCAATAAAATAAAGAACAAGAATCTATTGTATCGCTTGGAGTCACAGTTACGCTTACCCAAATAATGAAAAAGAAAGCAAAGTTCAAGTTTGTGTAGTTGTAATAGGAATCAGATTCAGAATAGGCATATCAATGAAGGCAAACCATTGATACGGCGATGACTGCTTCAGTGAGATAAAAGAATTTATATCAAAATAGCGAAACAACTTTCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTAACATAATGCTGTAATTGTACGCACCATATGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAA
+
%(*+)&&&''*)3264765)8:65-454&$%340&)/557/04)()%$$#&&$'%%'/$%#%1(=>?=E=35::EFJC88=>=921*)61157GF3'F@9$''&55%%#45:6=3258.'&($+3?9:66-)(-082..8=8=;7<30-,-.0&'05.<C77:>8-''&'9<<51436658)?5=89:<DCDPB%5:?LOKC?>;>=>2*&&$%(*5<<2214716/.,&&9EGFD:<4686@DB=?:9:89AB65C=+/+2((((%2179:643BHCG?>)'()(*>DCIAE?;<&-//24<95-(098<:=33=BDD9=<B<=$:**?28;>99%(
@c182bd3d-66e3-4c7a-91e6-97d3bf72186a
GAGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAACAAAATGGCGCAATAGAAGATCTAATCATTGCTCACACTTTGATATAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAGATAAGCCATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGGCAATAAGAATCAGATTCTAGAATAAACCATATCAATGAAGAACAAAACCGTGATACCACTGACGATGACTTCCAGCCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTCATAAAATTTAACATAATGCTGTAATTGTACGCACATGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAA
+
<05''+=BA478BE93<.0686487:1177>@8664/-4-7:BFFH><=AB?4;==>??@GC;4499B=FCB@=AB?CD<@6B>?1-.:AC3.'%->ADB@6&&240;<@?AD>B@FF053;/&%$$%(++;8733(9>'509A;@BD<>AEF>C1CDF@89:ECBKAAFJCDH@F=@AE(/74/&&-)$'&'(?56<5;A9C88:3449<>A>22<E>?@CE<9AD@BA?D4%19975@FF0):@CD131CF;2DDF6*9BB0&#9;:()426,6-6,5145977:5*+&'))')+,;=8..D136@EFFA>,$6768-,+5:5DD;9>9>-$+-%*+$*509?EC?C;FOO2*4;AELGK=7AJMKMB9;78;D07''@B6<BBAFFEILL;15)/,0<AFFF7?C<<HNB6ACDBB3'-0?@0A?B.;?A>A@CCHCGAAHJFK=77C6:)0$%&(9941+49:88@<32436;A2;/.','(0.43547??
@d3f5a05a-bbb0-4883-ac02-1c9e6188a6a6
CCGGTATGCTTCGTTCGGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTATAAGAGACAGCTTTGAAGTAGAAAATAGCACAGAGAAGATAACGCTCAGGACAGGATGCCGAACGGCACAACAGAGTAAGGAGAAAATGTCACATAAGGCGCTCTTCCGCTTCCTCGCTCACTTTGACTCGCTACGCTCGGTCGTTCGACTGCGGCGAGCAGTGTCAGCTCACTCAAAAAAGCGGTAATACGGTTATCCACAGAATCGGGGGATAAAGTCGGAAAGAACATGTGAGCAAAAGCAAAGCACCGGAGAAACCAGCGCCTGCGGGCGATTTTTCCATAGGCTCCGCCCCCTGACGAAGCACATCCGCAAAAATCGACGCTCAAGCCAGAGGTGGCGAAACCCGACAGGACTATAGCAAAGATACCAGGTGTTTCCCCCTGGAGGAAGCTCCTCGTGCGCTCTCCTGTTTCCGACCTGCCGCTTACCGGATACCGCAATCCGCCCTTTCTCCCTTCGGGAAGCGTGGCGCTCTCATAGCTCACGCTGCGCGGGTGGCATCTCCCGTTCGGTGTGGTCGTTCGCTCAAGCTGGGCTGTGCACGAACCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGGGTCCAGCCCGGTAAGACACGACAAAGCGCCACTGGCAGCAGCCATTGGTAAAGTCGATGTGCGAGGTTCAAGAGAGTACTTGAAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAGAACAGTTACCTGGTTAAGCAGTTCTGGCTGGCTCAACCTTCGATCAAACCACCTCCCCAGGTGGTTTTTCGTTTTCAGTTTAGGAGATTACGACAGAACACAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAGAAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAAGTTTAAACATGATAAAGATATCCATAAGGAAATTTTAAGTGTTTCGAGCATAACTCTCAAACAACTAAACACTTAATGTAATATCCGGAAAAAACAACTTTGGGAGAAAACATCGATGTTAGACGCGATATTTTCATTTTATGACGTAAAAAACCCAGCAGCTCTGTTAAAAGTAAAAAAGCTTTAGAAATGAAGCATCTCTCTTTTAAATAAGAAAACTCATTTTGGGGATAGCTATTTTTTATAACATGGACACATCAAAGAAATATCCATAACAATAATGAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACACAAAATTGAGATAAAACAATGGATCCACTAAATGTTAGTCAATATTATAAACACCCTCATTGCGACAAACCTCAATACTCAGAAGAATATTTTATTAGTTAAGATAGTGATTGCAGGTACGGAGGGAACTAGAAATTAGTTATATAAATATTTAAGCAAAAGAATAAATGAATAAGAATAAAAAACCACAAAAGGATTATTTATGATTCAAAACCGCGAGGTAGTAGCCACGTCAAGGCATAGACAGAGGCAACGATAAAAAACGTATCAAAACTACTAACACAAAAAGAAAAGATGGAAATAATAGGCAACCTAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTAGATATAGGACTAAGTAAGTTAAGTAAATATCAGTACTTGAGTGAAGGAGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAAGACTCAGTATTCATTGATGTAAGGATAGAAATGGAAATTCATTACTCAGTAATCAAAGATATAATCAACGCTTTGATAGAAGCAGCAAAAAACCAATAATAATCAAATATTTACAACAACACGCAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAAGAAAAGATATATCTTACATAAGACTGGGGAAGAGACAAGGAATCTCAAAAACCTACAACAATGCAATTTAACATGGATAATTTTTTTTTTTTTTTTCTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAGTGAAACCGAGAAAAATAAATGATTATAAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAACATATAGAGTCTTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGGAGCTTAACGTTTCATCACCAAGCTCGCATAATGGAAATATGCATTAACGGAAGCACAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATCATTGCTCGCGTGTAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAGAACAAGAATCTATTATTACATCCCATAGATCCTGATTACGCTTACCCAAATAATGAAAAAGAAAGCAAAGTTTCAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACACAGCTTCAGTGAGATAAAGAATTTATATCAAAATATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAGAGATGTTTTACGGGAAAACAGGAAGGATGCGTCAGGATCGTTTCAGCTCGCTGCATAACTATGCATGAAAGCGAATGGTGATCACTTTAAGGAACTTGGTGTTCATACCGTCTGTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCGCGGTCTGGATAACAGGGCACGGTGATGCTCCGTAATAGCGATCAGCACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCCCAGTCTCCACTTAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTGCGAGAGCTGCGCCCGTAAAAAACCGGGAAACAGTCTTGCCGCATTCAACAGCCCTTTTCACAGTTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTGTCATAAAACATGGCTCCGTATCTGACATGAGTGTCGGGGCAGAAGCCTGATGCGGGCAATTGTAATAGCGATGCATGTATGCGCGGTATAACAATTGCACATCCTGTCCCTGTCAGCAAGCTCGAATTACCGACAAAGGCCTGGCGAGTTTTTGGCAGTGACGGTGTTGTCTGACAGAAATGCCCGTCAAAAACCAAGCGGCAGAATAACGGCAACAAAACAGTCGAAAAGTGGTACGCGATATATAATCACACAACGCAGATGACAGACAGAACGGAGAAAACGAAAAGATGAACAAGCAGCAGCAAAGCGTACTCCAGCTTGGCGGGATTCGCCAAAAGTCAGGCCTGACGCTGCTCGAAAAACTGGACGCGCCGGTCACGCACCCACATTATCCTTTATTTCACGCGCACATTACACATTTACT
+
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
@312aea9f-74af-4bab-b77a-bc29c243e967
CTGATATTACTTCGTTCGATTGCGTATTGCTGCGCGCACTCTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACGAGCTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGGGATTTTTCTTAGCCCCCAGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTACTTTCTTACCGAGAGCTGCCGCCATGCGCTAAACAGTCTTGCCGCATTCAGCAGCCCTTTCTGCATTTCCTGGTCACTGTACACCGTCAGACACGAACAGGGCGACGTAACCCGCCTGCGCGTATTACTTCGCTGATTTTGTCATAAAACATGGCTCCGTATCTGACATGGGTGTCGGGGCAAAGCCCTGACCAGAACATTGTAATAGCGTGCATGTATGCGCGATATAACAATTGCACATCCTCATCTTCATCAATGACTGAATTACCGACAAAGCGCGGCAGTTTTTGGCAGCGACAGTGTTGTCTGATAAATGCCCGTCAAAAACCAAGCGGCAGGCGTAACGGCAGCAAAACAGTCGAGAAGTGAGCGATATAATCACACAACGCAGATGACGAACCAGAACGGAGAAGAAAACGAAAAGATGAACAAGCAGCAGCAAGCCGTACTCAACATGGCAGGATTCATAAAAGTCAGAACCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTGCTACGAACTCGCGGAAGAACTCAGAACAGCATCCAGACACGCTTTGGAAGTAGAAAATAGCACAGAATAACGCTCAGGACAGGATGCCGAACGGCTGAAAGCAGAGCGTAAGGAGAAAATGTCACATAAAGGCGCTCTTCCCGCTTCCTCGCTCACTGACTCGCTACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCAACTCACTCAAGCGGTAATACGGTTATCCACAGAATCGGGGATAAAGTCGGAAGAACATGTGAGCAAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCGGCGGTGCCATAGGCTCCGCCCCCTGACGAACATCACAAAAATCGACGCTCAAGCCAGAGGTGGCGAAACCCGGCAGGACTATAAAGATACCAGGTGTTTCACAGGCTCCTCGTGCGCTCTCCTGTTCCCGACCACCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTGCATAGCTCACGCTGGCGCCAGGTATCTCCGGTTCGGTGTAGGTCGTTCGGCTCAAAGCTGGGCTGTGGCGCTTGGGCTCCCCGTTCAGCCCGACCGCTGCGCCTTGTCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACAAGGCGCCACTGGCGGCAGCCATTGGTAAAAGTCGATTCTGCGAGAGGTTCAAGAGAGTACTTGAAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAAGACAGTTCACCTGGTTGAAAGCAGTTCCCCAACTGACAACCTTCAGATCAAACCACCTCCCCGGGTGGTTTTCGTTTTCAGTTTAGGGAGATTACGACCAGAACACAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAGAAACAGTATTGTAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACATGATAAAGATAATATCCACTTAAAATTTTAGAGTGTTTTCGAGGAGCATAACTCTCAAAACAGCTAAAAACACTTAATGTAATATCCGGAAAAAACAACTTTGGGGAAAGCCATCGATATTAGACGCGATATTTTCATTTTATGACGTAAAAAACCAGCAGCTCATTAAAAGTAAAAAGCTTTAGAAATGAAAACATCTCTTTTAAAATAAAGAAAACTCATTTTAGGATAGCTATTTTTTATAACATGGACACATCCAAAAATGTCATAACAATAAGAGATGAAAGAGATTGATAACACAAAATACTCAACGATAAGATAACACACAAAGTGAGATCAAGCGTGTCCCTCAATGTTGAGTCAATATTGTCATTGCCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAAGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAGAACCCACAGAAGAATTGATTACTATAAAATAACACAAAAGCACAAAGAAATAAACGAAATAAAACAAACTAAAAAGACAGCTATATGAATTCAAAGCTATGACATTAATAACAACCACATCCAAGAAACATAAACAAAGAAGCAACGATAAAAAACGTATCAAAACTGCTAACACAAAAGAAAGATGAAATAATAGGCAACCTAAAAGAATAGATAATAAATTAACGATATTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGGAGTAAGCAGAGCGCTGTCAACACCATTAGCTCAATCTTAGTTCAAAAGACTCGAATTATTCTCATTGATGAGATAGAAAATGGAGATTCATTACTCAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAATAATCAAATATTTACAAGCAACACACAGCCATGATGTAATATATTACGTGAAGCAGATTAGATGAAAAAGAAAAGATATATCTTACATAGGAGGCTGGGAAGAGACAAAGGAATGTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTCTTTTCCAGTTGAAAATGGCTGGGAGGTGAGATAAATGAAACCGAGAAAAGAATAATGATTATAAAAAGTCATTTTTCGTTGAGGGGTGATGATGATTTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGGCATTTTAAAGCATAGAGTCTTTTAATGAAGAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTTACCATCACCAAGCTCGCATAATGGAAATAGCCATTAACGGAAGCACAAGAAATATCTTTCTTTATCATGCCAGGAAAAAACAAAGAATGGCGCAATAGAATCTAATCATTGCTCCCGCGTGTAAGAAGGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAGAACAAGAATCTATTATTACATCCTTAGATCCTGATTACATTTTCCCAAGCCGTGAAAAGCAAAAGTTCAAGTTTACCTTGATTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAACCATTGATACTGACGATGACTAGCTTCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATTTAGCGCAATGACTAAAGACAATTGCAAAATTTAACATAATGCTGTAATTGTACGCACCGCTAAAAACGCTGAACGCGATTCTGACGCAGACACCGCAAGAGATGGCTTTACCCCGGGAAAACGGAAGATCACGTCAGGATCGTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATGCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACGGGGCACGGTGATGCTCATCATCAGCGGTCAGCACCTCCGCGCCTCCCTGTCCCTGTCTCTTATACACATCTCCGGAGCCCACGAGACCAGAGTGCGCGCGCAGCAGTATTGCGTAACT
+
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
@49b3c5fc-395b-43bd-92d8-5bc6cdee2622
AGGAATTAATGATGTTTATGTTGAAAAATAAATGGAAAGGCAAAAACGCGGCTCAAACCCTTAGAGCATTTAAAGCATAGAGTCTTTTAATGAAAAAGTATATTAATCATCGGTGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACAAACTCGCATAATGGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTGTCGTAGCGGCGGAAGCAAGAATGGCGCAATAGAAGACAATCATTGCTCACGCGTGTAAGGAAAAGAGGTGTTTAGATATATAGACGATCCTATTCAATAAAATAAAAGAAACAAAGAATCTATTATTACATCCTTAGATCCTGATTACATACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTCTGTAGTTGTAATAAGAGATGGGGTCCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTTCTTCAGTGAGATAAAGAATTTATAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAGAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGTACCGCAA
+
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
@84548d9a-6aff-40a3-b5dc-d51cecfc3152
GGTAATACTTCGTTCAGGTTACGTATTGCTGCGCGCGCGCACCTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAGACAGGGTATCACCGTGCCTGTTATCAGACTTATGGCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCGAAATTCGCTTTCATGCATAGCTATGCAGCAAGCTGAAAACGATCAGCGCTGTCCTTCCTCGTTTTCGGGTAAAACATCTCGCGGTGTCTGCGTCAGAATCGCGTTCGGCCTCGTTTTCAGCGGGTGCACGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTTCATATTTTTGATATAAATTCTTTTATCTCACTGAAACGATCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAAGAATCTGATTCCTTATTAACTAAAATTAAGCTTGAACTTTTGCTTTGCTTTTCATTATTTGGGTAAGCGTAATCAGGGATCTGAGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATAAGTTAGATCTTCTATTGCGCCATTCTTGTTTTTTCCTGGCATGATAAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCCTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCAGCATCGATGATTAAGAATATACTCTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTAGTTTGTCTTTCCATTTATTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTTTATAATCATTTATTTTTCTCAGTTTCATTTATCTCACACACTCCCAGCCATTTTTTCAACTGAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTGGGTTTTTTGAGATTCCTTGTCTCTTCCAGTCTTGTAGAATATATCTTTTTCTTTTTCATCTAATTCATTTATCATACATATTACATCCTTGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCGAGAATAATTGAGTCTTTTGAACTAAGATTGAGCTAATGAAAGACAGCTGCTCTGCCTCCTTCACAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTGTGTTAGTAGTTTGATACGTTTTTATCGTTTATTTTCTTTGTTTATGTTTCTTGATGGTTATTATCGCTGCGGTTTGAATTCATATAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTATTATTTTTATAGTAATCTCAATTCTTCTGGGGGGTTCTTTTTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCACGAGAGCCGAGGGTTTGTCGCAATGGAGAGGGGGTGTTTGATAATATTGACTCAACATTGGGGACACACTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTATTATTTATATGGACATTTCTTTGGATGTGTCCATGGTTGTAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAGCTTTTTACTTTTAACAGAGCTGCTGGGTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAGTTGTTTTTCCGGATATTACATTAAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACCTTAAAATTTTTAAGTGATTATCTTTATCATGTTTAAACTTGCTCTGCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTGTTATGCATCACTATGCCATATTTCTTTTCTAGAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCCTTAATCTCCTAAACTGAAAACGAAAAACCACCTGGGGGAGGTGGTTTGATCGAAGGTTAAAGTCCTGTCTCTTATACACATCTGACGCTGCCGACGACAGA
+
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
@7f2c020d-3918-410c-a2dc-d970e094d65b
GGTGTGCTGGTTCGGTTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCGGCGGGCGTCAGATGTGTATAAGAGACAGACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCTACAGCGTATGAGCTATGAAAGCGCCACGCTTCCCGAAGGGAGAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGCGCACGGGGAGCTTCCAGGGGAAACACCTGATATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCAGGGCGGAGCCTATGGAAAAACGCCTGCGGCGCTGGCTTCCCTCCGGTGCTTTGCTTTTTGCTCACATATTTCTTGACTTTATCCCCCGATTCTGCTTGGATAACCGTAGCCACGCTTCTAGGAGTGAGCTGACACCGCTCGCCGCAGTCAGGCGACCGAGCGTAGCAGTCAGTGAGCAGGAAGCGGAAGAGCGCCTTATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTTAGAAAATTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACATGGCAGCCTGTTCGTCGGCATCGGGTGCGTCCAGTTTTCGAGCAGCGTCAGGCTCTGACTTTTATGAATCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCATCATCTGCGTTGTGTGATTATATCGCGTACCACTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTAGGCTTTTTTGTGAGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGTGCATTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTACAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAGGGCTTTTGTTCACCCATGTCAGATACGGAGCCATGTTTTATAACAAAACGAAGTGGAAGTAATACGCGCAGGCGGGCTATCCAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAGAAAAGGCTGCTGAATGCGGCAGAGACCGTTTCCGGTTTTTTACAGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTGTAAGGACTGGGGCGTTACCGGAAAAAACTTTTATCGACGGCAAGCGTGTGGGGACAGAAGTATGCAGAGTGCTGATCGCTATTACGGAGTATCACCGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACAGACAGTATGAACACCGTAAACTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTTACGGTGTCTGCGTCAGAATCGCGTTCAGCACATTCAGCCAGTTACGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTTTGATATAAATTCTTTATCTCACTGGAAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAGCTAAGGTAAGCTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAGGATGTAATAATGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATCGTTAGATCTTCTATTGCGCCATTCTTGTTTTTCCTGGCATGATAAAGAAAGATGTTTTTTATTGCTTCCGTTAGTGGCTGTTTATTGTGAACTTGGTGATGAAGTGTTCGCTCATTCAATGTTGAAATTATCGATCTTTCGTGTCAGAAAACGTTCGTCAACATCGATGATTAAGGAATATACTTTCTTTTTCATTAAAAGACTCTATGCTCTAAATATCTAAGGGTTTGTTTTAGTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCATTCGCAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCTTGTCTTCCCAGTCTTATGTAAGATATATCTTTCTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCATCAATGAGAATAATTGAGTCTTTTGAACTAAGATTGAGCTAATGAAGACAGCGCTCTACTTACTCCCTTCACTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTGTGTTATTAGTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTGAGGACGCGCTGGTTCACTTTTGTATTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTATCTGTTGTGGACATTTCTTTGGATGTGTCCATGTTATAAAGCCATTATCCCAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTATAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTCGGATATTACATTAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTCGTTTACATAGTAATAATGTGTTTATTTATGCATCACCATACTGTTTCTTTTCTAGAAATTGTAATCAAAATAATATTGCTTTACATAGTCCTGTTTGGATTGATTTACGCTCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCTAAACCAAAAGCGAAAAACCACCTGGGGAAGTCTGGTTTGATCGAAGGTTAAGTCGGTTGGGGAACTGCTTGGCTCGGGTAACTGTCTTGTGCGAGACGAGTCCGCAAAGCTGTCCTTTCAGTGTAGCTGTGAGTCAGATACATCCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTACCAATGGCCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAGTGCGCGCGCAACAATACGTAACC
+
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
@75ad91c0-8265-449e-8c82-e7e82fe4b1b7
CGGTGTCTGCGTCAGAATCGCGTTCGCGCGTTTTCAGCAGAGCCATACAATTTACAGCATTATATTAAATTTTATAATTGTCTTTTAGTCATTGCGCTTCTATGATTTTGGGGTGGGGTTATTTCATATTTTTGATATGAATTCTTTATCTCACTGAAGCAGTCATCTAATCCAGTATCAATGGTTTTGTTCT
+
/$)-,)'+188360/+/'A8:7;6%&#$(#$/8*'-''&)$%$%$%$$24201+-00@=AC=7799676DEG3:;2339(5569=7//8<3;8)+%#%)&.9676KDF4%'%%3''&>64%%&.'$(,''%%%*%)%%$%%01..41715*)&$'',3'2/18@+&3$()))-$0:;<A8:A8<;EG8/51()
@a0e3ba3e-b9f0-4d02-b2ff-80c735cb38a8
GTTGTACTTCGTTCAAAGTTACGTATTGCTGCTTTTTCTCTATCGTCGGCAGCGTCAGATATAAGAGACAGCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCATTATCTCTGCAATGCTATTTCTACTTCCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATGGCAACCTGTTCGTCAGCATCAGGTGCGTCAGTTTTTCCGAGCAGCGTCAGGCTCTGACTTTTATGAATCCCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGCTCATCTCTTTTCGTTTTCTCCGTTCTGTCTGTCATCACGTTGTGTGATTATATCGCGTACCACTTTTCAGCTGTTTTGCTGCCGTTATTCTACTTCCGCTTAGCTTTTGACGGAGCATTGTTTCTGTCCGAGACAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGTCGGTAATTCAGGCTTGCTGACAAGGACAGGATGTGCAATTGTTATACCGCGCATACATGCACGCTGTACAATTGCCCTGGTCAGGGCTTTGCCCCGACACCCATGTCAAGATGAACCATGTTTTATGACAAAACGAAGTGGAAGTAATACGCAGGCAGGCTATCAGTCGCCCTGTTCGTCTGACAACCCAGAAGAAGACCAGGAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAGTTATGAGACTGGGGCGTTACAAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCGGAGGTGCTGATCGCTATTACGGAGTATCACCGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGTGAAAACGGGACGTTATGAACACCGTAAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGAATCCTGACGCATCCTTCCTGTTTTTCCCGGGGTAAAACATCTCTTTACCCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCGATACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTAGACTTTGCTTTCTTTTCATTATTTGGGTAAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTCTATTGAATGAATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAGATCTTCTATTGCGCCATTCTTGTTTTTTCCTGGCATGATAAAGAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAGAATACACTCTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTTGTTTTAGTTTTGTCTTTCCGTTTTATTTTCAACATAAACATCGATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTTATAATCATTTATTTTTCTCAGTCTCATTTATCTCACCTCCCCAGTAGCCATTTCAACTGAAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCCTTCACCAAACATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAATCTCTTTAGTGTTTTTGATCTGTTGCTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTGTGTTATTAGTTTTGATACGTTTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCACTGCGGTTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTATTTCTCGTTTATTTCTTGTGCTTTTTGTGTTATTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCCTGAGAGCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAATTGAGGACGCTTGATTCACTTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAAGATGCTTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTTCCCAAAGTTGTTTTCGGATATTACATTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACATAAAATTTTTAAGTGGATATCTTTTATCGTATTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCCACTATGCCACTGTTTCTTTTCTAGAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCCTTAATCTCCTAAACTGAAAACAGAAAAAACCACCTGGGGAGGTGGTTTGATCGAAGGGTCCAGTCAGTTGAGGCTTTTTCGCCAACCAGGTAACTGTCTTGTGCGAGACGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGACCATCACTTCAGAGTACTCTCTTGACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATGGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCTACAGCGTGAGCTATGAAGAAGCGCCACACTTCCCGAGGAGAAGGCGGACAGGTATCCGGTAAGCGGCGGGGGTCGGAACGGAGAGTTGCACCAGGGGAGCTTCAGGGGAAACACCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCAGGGCGGAGCCTATGGAAAAACGCCTGCGGCACTGGCTTCCTCCGGTGCTTTGCTTTTTGCTCACATGTTCTTTCCACGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGAGGTGAGCTGAAACACCACTCGCCGCAGTCGAACCGACCGAAGGCAGCGAGTCAGTGAAACGAGGAAGCGGAAAAGCAACTATGTGACATTTTCTCCTTACCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAGAGTGCGCGCGCAGCAATACGTAACT
+
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
@ea1ef195-81f5-4c7a-8560-1aac0bf0a13a
CGTTAGCGGTTACATTATTGCTGCGCGCACGCTCTGTCGTCGGCAGCGTCAGATGCTCGCCAGGGAACCAGACCCCATAAAGATACCAGGTGTTTCCTGCCTAGGAGCTCCTCAGTGCGCTCTCCTGTTCCGACCTGTAAGCACCCAGGTTGCTGCCTAATCCCATATGGCACTGTCTACTACGCACATGTCTGCTACGACTGGGAAATTTGCGCGCTCTCTCATAGCTCACGCTGCGGGCATCTCCCGGTTCGGGTGTAGGTCGTTCATCTGGGCTGTGTACACGAACCCCGTTCAATGACGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCAACCAGTGGGCGACCAAGCTGCGCTTGGCTTCATTGGTAAAAGTCGATGTGCGAGGGTTCGAGAACGCGGAAGTGATGGCATTACACACCGCAGCTACACTGAAAGGACAGTTTGGATGACCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTGTGACTTATTGCCTTCAGTCAAACCACCTCCCCAGTTTGGGTTTTGCAATTTTCAGTTTAGGAATTACGACCAGACACAATAAATACAAAGCTCCGGCAAGCTGGTTAAAATTAATCCAAACAGGTTCATAAAGTAATATTATTTGATTGTCACTTTAGAAAACAGTGGCATAGTGATGCATAAATATTCATTTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAAACATGATAAAAGATATCCATAAAAATTTTAAGTGTTTTGCGAGTATAACTCAAACAACTAAAAACACTTAATACTTAATATCGAATAACGGGAAAACGCATCGATATTAGACGCGATCTTTTTCGTTTTTATGATAAAAAAAATGAAACAGCTCTACATTTAAAGTAAAAAACACTTTAGAAATGGAAGCATCCTCTTTTTTAAATAAAGAAATATCATTTTGGATAGCTATTTTTATAACATGGACACACAAAGAAATGTCATAACAATAGAAGTCAGTCAAATAACACAAAAATACTCAACAGGTAGATAACACCTGGTAGATCAGCAGTGTCCTCAATGTTGAGTCAATATTATCAACCTCATTTAAGACAAACCACCAGCTCTCAGGAAAAGGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGAACCCCCAAGAAGAATTGATTACTATAAAAATAACACAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGATGACTATATGAATTCAAAACCGCAGCGATAATAAACCACATCAAAACATAAACAAAGGAAACAGCGATAAAAAACGTATCAAAACTACTAACACAAAAGAAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATATTTAGAATTAACGATATTGCAATAATAGCAACGAAAGATCAAAACAAAAGTTTTTTTTTTAGATATGGGACTATGTGAATTAAATGAAATATCAATGCTTGAGGTGAAGGAGTAAGCGACGCTGTCTTTCATTAGCAATCTTAGTTCAAAAAGACTCAATTATTCTCATTGATGGGACGAAAATAGAATTTCATTACTCAGTAATCAAAGATATGATCAACACTTTGATAGAAGCAGCAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAAGAAAAGATTATATCTTACATAAGACTGGGGAAGAGACAAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTCTTTTTCAGTTGAAAGTGGCTGGAGGTGAAATAAATGAGACCGAGAAAAAATAAATGATTATAAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTTGCAATCTACTTGAAATAAGAAGGAATTAATGATGTTCATATTGAAAAAATAAATGGAAGAGATAAACTAAAACAAACCCTTAGAGCGTTACATAGAAGTCTTTGAAGAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTCTGACACGGAAAGATCGATAATTTCAACATTAAACCCAACATCTCATCGCAAGCTCGCATAATGAAATAGCCATTAACAGGAGCACAAAATATCTTTCTTTATCATGCCAGGAAAAACAAGAATGGCGCAATGGAAGATCCCCAATCATTGCTCACGCGTGTATAAGAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAATAAAAAAGAACAAAAGTCTATTATTACATCGCTAGATCCTGATTACGCTTACCCAAATAAGCTGAAGAAAGCAAAGTTCAAGTTTACCTTGGTTAATAAGGAATCAGATTCTAGAATGAGCGCATATCAATGAAGAATATAAAACCATTGATACTGACGATGACTTCTTCAGTGAGATAAAAGAATTTATATCAAAATATGAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAAGGATTTAACACTAATGTAATTGTACGCACCATATGAAACGCGCTGAACGCGATTCTGACGCAGACACCTGAGAGATGTGTTTTGCGGGGAAAACAGGAAGGATGCGATCAGGATCGTTCAAAACTTCGCTGCATAGCTATCATGAAAGCGAATGGTGGTCTTTTGGGGCGCGGTGTTCATACCGTCTGTTTTCGGCAGTTTTCTCTCCGGGAAACTAATCTACCATAGAATCACGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAACACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCGCGCCCCGGTCTCATAACTTCTTTCAGTACCGATCGCCAGTCAGTGAGTTAACTTTCTTACCGAAGAGCTGCCGCCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTCTGATTTCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCCGCGCGTATTACTTCCGCTTCCGTTTTGTCATAAACATGGCTCCGTATCTGACATGGGCTGTCTCTTATACACATCTCAAGGCCACGAGACCAGCGCG
+
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
@9404d965-923b-422d-ab06-0ceaf29e55a5
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGATAAGTCGACAGCGTCAGATGTTATTTATAGAGACCAAACCCCCGTTCCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCCCGAGTCCAACCCGGTAAGACTACGACAAAGCGCCACTGGCGGTAAAATTGGTAAAGTCAGTGTTTGAGAGAGGTTCAGAAATTGCCCGAAGTGATGGCCTGACTACGGCTACACTGAAAAGGACAGTTTTGGTGACTCGTCTCGCTAGAACGATTACCTGGACAACAGTTCAGCAAGCGCCAACATGGTAAGCCACCTCCCCAGGTGGTTTTCGTTTTTCAGTTTAGGAGATTACGATAAGGAACAATAAATACGACGACAAACTGGTTAAAATCAATCCAAACAGGACTAAGGTAACATTATTTGATTATACTTCTAGAAAAACAGGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAGCAGAAATGGAGAGCGATTTAAACATGATAAAGATATCCACTTAAAAAATTTTGAATGAACTTAGGAGTATAGCTCTCAAGCAACTAAAAACATAATCAATAATAATCCCGAAACAAGCTTTGGGAAAACATCGATATTAGACGCGATATTTTCATTTTATGACAGCAAAAGCCATGGCTCTGGTGAAAAGTAAAAGCTTTGAAATGAAGCATCTCTTTTAAAAATAAAGAAAACTCATTTGGGATAGCTATTTTTATAACATGGACACATCAAGAAAATGTCCATAACAATAAAGAGATGAAAGGTCAAATGGCACAAATATGGCGATGAGATAACACCTACAAAGGTGAATCAAACGTGTCCACTCCAATCCCATTGGAATCAATATTATCAAACACCCTCCATTGCGACAAACCCTCGGCTCTCGGGAAAAGGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAGAACCCCCCAGAAGAATTGGATTACTATAAATAACACAAAAAAGCACAAGAAATAAACGGAAATAAAACAAATCTAAAAAGGTAAGCTATATGAATTCAAACCTACGCAGCGATAATAACTACATCAAGAAACATAAACAAAGAAGCAACGATAAAAAACGTATCAAAACTACTAACACAAAGAAAAGATGAAATAATAGGCAACCTAAGAATGGTAATAGAATTAACGATATTTTGACGACATAACAGATCAAAACAAAGAGATTTTTTTTTAGATATGGGGACTAAGTGAATTAAGCTGAGGAAATATCAATGACAACGGTGAAGAATGCAGCAAGAAAACAGTGCTCAATTAGCTCAATCTTAGTTCAAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCCCAGTAATCAAAATATGATCAACGCTTTGATAAGAACGACAAAACCAATAATAATCAAATATTTACAACAACACACATCTTGATGTAATATGTGCGATGACAATTAGATGAAAAAAGAAAAGATATATCTCCCACATAAGACTGGGAAGGGGGCAAGGGAATCCTCAAAAACTGACAATGCAATTTAACATGGATGAATTTTCTTTCAGTTGAAAATGGCTGGGAAGGTGAGATAAATGAAACCGAGAAAAAAATAATGATTACTAAAAGTCATTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTTGCAATCTATGAAATAGAATTAATGATGTTATATTTTGAAAAAATAAATGGAAAGAATAAAACTAAAATAAACCCTTAGAGCATTTAAAAGCCACATAGGTCTTTTTAATGAAAAGAAAAGAAATATCGTTCTTAGTCATCAATTTCTCCAGAACTGAATCTGGTTTTCCTGACCTGGAAAGATCGATAATTTCAACTGATAAATGAGCTTAACATTTCAAATCATAAGCTCATAGTAAACTAATATAACAGGCTTCAAAAATATCTTTCTTTATCAGGAAAAAACAAGAATGGCACCAAATAGAAGATCTAATCATTTTGCTCACGCGTATCAAGAAAGGGTGTTTGATATATGAGCGATCAATATCAATAAATAAAAGAACAAGAATCTATTGTGGTATCCTTAGATCTGATTACATACCCAAATAATAGAAAAGCAAAGTTCAAGTTTATATAGTTGTAATAAGAATCAGATTCTAAGAATAGGCATATCAATGAAGAACAAAACCGTGATACTGACGATGACTTTGCTTCAGTGAAATAAAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACCCAAGACAATTATAATTTAACATAATGCTGTAATTGGCGCACCGCTGAAAACACCCGCTGAACGATTCTGACGCAGACACCACTGAGTGTACCGGGAAAAACAGGAAGGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAACTTATGCGCAAGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCCTTCTGCGTCTGTTTTCGACAGTTTTCTCTCAGGAAGCTAATCACCATGATCTGGATGGCAGGGCACGGTGATGCTCCGTAATAGCGATCAACACCTCCACCATACTCCCTGTCCCCATTACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCCAGTCTCGCGCTTCTTTCAGTACCCGATCATCAGTGTTGAGTTAACTTTCTTACCGAGAGCTACCGCCAATAAAAACGGAAACGGATAGCACCGCATTCAACCCTTTTTCTGATTTCCTGGTCTTCTTCTGCCGTCAGACAGCAGGGCGACTGATTAGCCCGCCTGCGCGTCTGCCACTTCGTTTTGTCGCAAAACATGGCTCCGTATCTGACATGGGTGTCAGGGCGAAAGCCCTGACCAGACAGTATGTGCATCTGTGTACCAGTACCGCAATTGCACATCATGTTATCCTGTCAACAAGCTCTCGAATTACCGACAAAGGCACATGGATTTTTGGCGAAAGTGACAGTGTTCGTAATACCCGTCAAAGGCGACGGCAGAATAACGGCAGCAAAACAGTCAAGAAAAGAATAATTTTTGCCGATATAATCACTGGCCGCAGATGACAGACAGAACGGAAAACGAAAAGATGAACAAGCAGCAGCAAGCCATTACTCTATGGCGGGATTCGCAAAGTCGGGAAATGACGCGCTCGAAAACTGGACGCACCGATGCTGACGAACAGGCTACCATGTGAAGCTGCGAACTCGCAGAAGAACTCCAAGAACAGCATCAGACACATTTGGGTGAAAGCCAGCTGAAGATAACGCTCAGGACGGGATGCCGGAACGGCACAACCCGAACGTAAGGAAAAATGTCACATAAGGCGCTCTTCCGCTTCACTCGCTCACACAAACTCCTACGCTCGGTCAGTTCGACTGCGCTTGAGCGGTCAACTCACTCACGCAAGCAGTAATACGGTTATCCACAGAATCAGAGGATAAAGTCGGAAGAACATGTGAGGCAAGCAAACACCGGAGCCGGCATACAGTTTTCTGAGCTCCGCCCCCTGACCCGGTATCACAAAATCATGCAACTCAGAAGCTGGAAATTTGGCGAAACCAAACGGACTATAAAGATACCAGGTGTTTCCCCTGAGGCTCCCTCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATAGCGCCTTTCTCCCTTCGGGAAGCTGTCTTTCTCACAAGCTCACGCTGGCAGGTATCCCTCTCAGTTCGGTCTTTAAGGTCGTTCGCGCTCCAAAACTGGGCTGTGTGCACGAACCCCCTGTCTCTCGCCATCTGGCCTGCCGACGACAGAGTGCGCGCGCAACAATACGTAAC
+
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@427791bc-1553-4b07-9dc9-6b0ec338545a
CATTGTCGCCCCGTTCAGTTACGTATTGCTGCGCGCGCGCCTCTCTGTCGTCAGCGTCAGATGTATAAGAGACGGGGGTAAGCGGAGCGCTTTATCTTTCATTGGCTCAATCTTAGTTCAAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCGGTAATCAAAGATACACCAATCAACACTTTTGCACATTTAGAAGCAACTTAAAACTCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTACGATAAACGAATTAGATGAAAAGAAAGATATATCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAACCTACAGCAATGCAATTTAACATGGATGATTTTCTTTCAATTAATGGCTGGGAGGTGAGATAAATGAAACAAGGAAAAATAAATGATTATAAAAGGTCATTTTCATTGAGGGTGATGATGATTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAAGTCTTTTAATGAAAAAGAAAATAATATATTCTACCAATCATCGATGCCGACAGAATCGTTTTCTGACACAAAAAGATCGATAATTTTCAACATTAAAATGAGCTTAACATTTCATCACCAAACTCTTAATGAAATAGCCATTAACGGAAACACAAAAATATCTTTCTTTATCATACCCAGGAAAAAACAAGAATGGCGCAATGAAGATCTAATCCATTGCTCACGCATTATAAGAAAGAGGTGTTTAGATGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGATCATTATTACATCCTTAGATCCTGATTTACGCCCACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATACGACTGCTTCAAGTGAGATAAAAGAATTTATATCAAAATATGGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACACTCAATGCTGTAATTCTTACGCACACCGTGAAACGCGCTGAACGATTCTGACGCAGACACCTATAAAGAGATGTTTTACCACAGGGAGAGAGCAGGAAGGGATCACCATCAGGATCGTTTTCAACTTCGCTGCGTAACTATGCATGAAAGCGAATGGTGATCACTTTGGGAGGCTTACATTGTTCGCTTGTCTGGCACCGACAGTTTTTCTCTCCGGGAAGCCTTAATCTCTACCATAAGTCTGGATAACGGGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGGTTTTTCTGTAACGCCCCAGTCCTCGCGCTTCTTTCAGTACCCGATCATCAGTCGGTGGAATTAACTTTCTTTACCGAGCTGCCGCCCGTAAAGGCTCAAACAGTCAGCGCTGCATTCGGCCCTTTTTCTGATTTCCTGAGTCTTCTTTGCCGTCAGACGAACAGGGCGACTGATAAGCCCGCACTGCGCAATATTACTTCCCGCTGTTTGTCGCAAAACATGGCTCCGTATCTGACATGGGTGTCGGGGCTGAAGCCCTGATCAGGGCAGCAATTAGCGTATGGCGTGCCTGCGTGCCTTGTGATACATCTCCTGTCAGCAAGCTCGAATTACCGACAAGGCACGGCAGTTTTTGGCGACAGTGTTGTCTGACAGAAATGCCCGTCAAAGCCAAGCGGCAAGAATAACGGCACGACAAAAGCTGATCGAAAAGTGGTACGCGATATAATCCACTTTGTAACGGATGACAGACAGAGCGGAGAAAACAAGATGAACTGGCAGCAGCAAGCGTACTCAACGCGCGGCGGGATTCATAAAGTCGAGCCTGACGCTGCCCTTCGAAAAACTGGACGCACCCGATGCTGACGAACAAACGCCATGTGAGAAGCTACGGCTCCGCAGAAGAACTCAGAACAGCATCAGACACACGCGAGTAGAAAATGGCACAGAGATAACGCTCCAGGACAGGATGCCGAACGGCACAACAGAGCGTAAGGAAAATGTCACGCCGGACGCTCTTCCGCTTCCTCGCTCATGGCTCGCACGCTCCGGTCGTTCATTCGGCTGCGGCGAGCGGTATCAGCTCCTCAAAGCGGTAATACGGTTATCCACAGAATCAGGATAAAGTCGGAAGAACATGTGAGCAAAGCGAAAGCACACTAGGAGAAGCCAGCGCCGCGAGCGTTTTTCCCGCGGCTCCGCCCCCACAGCGAGCATCACAAAAATCTGACACTCAAATGAGGTTTGGCGAAACACCAAGTGAGATTCAAATTCAGGTGTTTCCTGGAAGCTCCTCGTGCGCTCTCCTGTTTCCCGACCCCACGCCATTTGATGCCGTAACACTTCTCTTCCGGAAGCGTGTGGCAGCATTCCTGTTATCGTGAATGTGCTTACAGATATCCGACTCAGGGTGCGATTAGTTCACTCAAACCCTAAGCGAGTACCAATGTATTCTTCCTAGCCTGTGCATACTATACATCTCTGAAACCTACGGAGATGAATGAGGAAAACACCATGAGCGTAATACATGGCAGCT
+
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
@31f4de4b-1957-4364-8908-852292f700a8
CGTCGGTATTGCTTCGTTCAGTTACGTATTGCTGCGCGCGCTCTCTGGTCTCGTGGGCTCCGGAGATGTGTATAAAGACAGGTCAGGCTCTGACTTTTTATGAATCCGCCATGTTGGTACGGCTTGCTGCTAGCGTTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTTATTCTGCCGCTTGGCTTTTTGACCCAGGCATTTCTGTCCAGACAACACTGTCGCCGCAAGAAACTGCCGTGCCTTTGTCAGTAATTCGAGCTTGCTGACAGGACAGGATGTACAGGAAGTTGTTATACCGCGCATACATGCACGCTATTACAATTGCCTGGTCAGGGCTTTGCCCCATGACTTACCCATGTCAGATGCGGAGCCATGTTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCGAACTATCAATAAGTCGCCCTGTTCGTCTGACGGCAGAAAGACCAGGAAATCAAGAAAAGGGCTGCTGAATGCGGCAAGACCGCGTTTCGGTTTTTACGGGCAGCTCGGTAAGAAAGTTAACTTACTGACTGATGATCAGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAAGAAAAAACTCTTTATCGACGGCAAATGATGTCGGGACAGGGAGTATGCAGGTGCTGATCGCTATTGCGCGGAGCATCACCGTGCCCTGTTAGCCCGGACATGGCAGATAGCTGCGGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCCTTCTGGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTCCCGGGGTAAAACATCTCTTTTTGTGTCTGCGGAATCGCGTTCGAAAGCGCGTTTTCAGCGGTGCGATACAATTACACAAGCATTATGCTAAATTTTATAATTGTCTTTAGTCATTTGCGCTATATTTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCCCAGTATCAATGGTTTGTTCTTCATTGATATGCCCTATTCACAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAATCACCTCTTTCTTACACGCGTGAGCAATGAAGTTAGATCTTCTATTGCGCCGTTCTTGTTTTCCTGGCATGATAAAGAAAGATATTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCAGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTAAATGCTCTAAGGGTTTGTTTTAGTTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAGTAGATTGCAAAGTGAAAATCATCATCACCCTCAACAAAAATGACTTTTTATAATCATTTATTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTCAACTGAAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTCTTCTTTTTTCATCTAATTCGTTTATCGCACATAATACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTCTATCTCATCAATGAGAATAATTGGTCACTTTTGAACTAAGATTCGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCGTTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTACCCTATTATTTCATCTTTTCTTTTTTTGTGTTGAAGTAGTTTTGATACGTTTTTATCATTGCTTCTTTGTTTATGTTTCTTGATGTGGTTTATTATCGCTGCGGTTTTGAAAGATTCATATAGCTTACCTTTTTTAGTTTGTTTGACTTCTCCGTTTATTTCTTGTGCTTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGAGAGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTGGGGACACGCTTGAGTTCACTTTGTGTGTTATCTATCGTTGAGTATTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATATCTCTCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTCTAAAGCTTTTTACTTTTAAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCAAAGTTCATTTTTCCGGATATTACATTAAAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTGAAACGCTAAAATTTTTAAGTGGATATACTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTCGGATTGATTTTAACCAGTTTGTCGAAGGTTTCTTCTTGTGATTATTGTGTTAGTCGTAACCTCTAAACTGAAAACGAAAAACCACCTGGGGAGAATTGGTTTGATCGGGATTAAAGTCGGTTGGGAACTGCTTAACCAGGTAACTGTCTTGTGCGAGACGAGTCACCAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCCAGAGTACTCTCTTGAACCTCTCGCACATCGGCTTTTTACCAATGGCTGCTGCCAGTGGCGCTTGTCGTGTCTTACCGGGTTGGACTCAGAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGGTTCGTGCACACGAGCCCAGCTTGGAGCGAACGACCTACACCAGACCGAGATACCTACAGCGTGAGCTATGAGAAAACGCCACGCTTCCCGAAGGGAAGAAAGGCGGACAGGTATCCGGTAAGCGGCTGGTCGGAACAGGGAGAGCGCACGAGGGGCTTCAGGGAAACACCTGGGTAATAGCTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCATCGATTTTGTGATGCTCGTCAGAGCGGAGCCTATGGAAAAACGCCTGCGGCGCTGGCTTCCTCCGGTGCTTTGCTTTTTGCTCACATGTTCTATCTCTTATACACATCTGACGCTGCCGACGACAGAGAGTGCGCGCGCAGCATTGCGTAAC
+
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
@d6b9cbaa-78f4-4533-8779-1ceb6b2637d0
CATTGTACTTCGTTCCAGTTCGCATTGCTGCGCGCTCTGTCGTCGGCAGCATCAGATGTACTCGGGAGCAGTTCACATGGCGGCAACCTGTTCGTCAACTCAGGTGCGTCAGTTTTCAGAAGCAGCGTCGACTCGGCTTTATGAACCCCGCCATGTTTGGTACGGCTTGCTGCTGCGCGTTCATCTTTCGTTTTTCTCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCAAGTACCACTTTTCGACTGTTTTGCTGCCGTTGATATTCTGCCATGGCTTTTTGACAGGCAGCTCAATCAAAACAACACTGTCACTGCCAAAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACGGGGACAGGATGTGCAGGCCTTGTTATACCGCGCATACGTACGCTATTACAATTGCCTGGTCGAGAACTGCCGACACCCATGTCAGATACAGAACCATGTTTTATGATGACAAAACTGAGTGAAGTAACGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGAAAGCGGCGAAGAAGAGACCGGGGAAGTATCAGAAAGGGCTGCTGAATGCGGCAAGACCGTTCGGTTTTTACAGGCGGCAGCTCGGTAAGAAAGTTAACTCACTGACTGATGGTCGGTACTGAAGAAGTTATGAGGCTAAGGGCGTTACAGAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGGAGTATACGGAGGTGCTACTGATCCGCTAATACGGCGTTATCACCGTGCCCGTATCCAGACTTATATGGCAGATTAAGCTTCCCGGAGAAAACGTGAAAACAGACGGTATAGACTGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATTTGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATGTCCTTCCTGTTTTCAGGGTAAAACATCTCTTTTTAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCGTACAATTACAACATTATGTTAAATTTTATAATTGTCTTTAGTCATTTACGCTATGATTTTGTAGGTGGGTTGTTTTCATATTTTGTTGATATAAATTCTTTTATCTCCCACTGAAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATGTACTATTCTAGAATCGGTTGTATTACAACTAAGGTAAACTTGAACTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCTATATATCTAAACACTTACCTCTTTCTTACACGCGTGAGCAATGATTGAATCTTCTAACATTTATATTCTTGTTTTTCACCTTGATAAAGAAAGATATTTTTGCTTCCGTTAATGGCTATTTCATTATGCGAAGCTTTGGTGATGAAATGTTAAAGCTCATTTAATGTTAATTAATGAATATCTTTCCACGTGTCAGAAAACGATTCGTCAGCATCGATGGTGTAGAATATACTTTCTTTCGCTAAAGACTCTCTATGCTTTTAAATGCTCAAAGGGATTGTTTAGTTTGTCTTTCCGTTTTATTTTTCAACACCAACATCATTAATTCCTTCTATTTCAAATAGTTGCAAAGAGGAAGTGAAAATCATCATCACCTCAACAAAGAAAATGACTTTTTTATAATCATTTATTTTTCTCGGTTTCATTTATCTACCTCCCAGCCATTTCAACTGAAGAAAAATCATCCATGTTAAATTGCATTACTATGTGGGTTTGAGATTCCTTGTCTCTTCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTTGTATGTGTGTTGTTTAATAAATATTGTTTGATTATTATTGGTTTTTACTTGCTTCTATCAAAGCGTTGATCACCTCTTTGATTACTGATAATGTTCCATTTTCTATCTCATCGACTGAAATAGTGGAGTCTTTTAGTTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTGCTATCCCAAAAAAATCTCTTTGTTTGATCTGTTTATGACTCTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTATCGTTGCTTCTTTGTTTATGTTTCTGGGTTATTGTTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACATGCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTTGTGTTATTTTTTATAGTAATCAATTCTTCTAGGGGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATATTAAAACATTCCCCTTTTTCCTGACCAGGGGTTTATACCAATGGAGGGTGTTTGATATGACTCAACATTAGGGGACACGCGCTGATTCACTTTTTGTGTATTATCTCCCTATCATTGAGTATTTGTGTTACTTCTGACCTTCCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAATAACTATCCAATAGTTTCTTTATTTAAAAGATGCTTCATTTCTAAAGCTTTTTTACTTTTAACAAAGACTGCTGGGTTTTTTTACGTCACATAAAATGAAAATATCATTCTATCACGATGTTTTCCCAAAGTTGTTTTTTCCGGATATTATTAAGTGTTTTAGTTGTTTGAGTTATGCTCTCGAAACGCTAAAATTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCTGTTTACGTTTTACACATAGTAATAATGTGTTTATTTATGCATCACTATGCACCACTGTTTCTCTAGAAGTGCAATCATAATAGTGAAGCTACTTTATAAATCCTGTTGGTTAGTTTTGAAACAGTTTTGTGGGTTTCTTCACTGTGATTATTGAACTGGCAAAATCTCAATAAGCAGAACCACCTAGGCGTTGAAGCGTCTAAGTCGTTTGCGACCTGCTAACATAGACTGTCTGGCAGACAGTCACCAAAACTGTCTTTCAGTGTGGCTGTAAGTCGGAGCCATCACTTCAAGTACTCTCTTGAACCTCTGCCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTGTCGTCTCTTACCAGGGTTGGACTCAAGACTGATAGTTACCGGATAAGGCGCAGCGGTCCGGGCCCCAGACAGGGTTCGTGCCTGGCCAGCAGGCGAACGACCTACCGAACCGAGATACCACTACAGCGTGAGCTATGAGAAAGCGCCACTTCCCGAAGGGAGAGGCGGACAGGTATCCGCGAAGTAGCGGCGGGAATCGGGTGGAGAGCGCACGAGGGAGACTTCCAAAACACCTGTTGACGCTGCTATGATCCTGTCAGCGGGTTTCGCCACCTCTGGCTTGAGCGTGCGATTTTGGCGCGTTATACTCGATCAGGGGCGACCTATGGAAACCTGCGGCGCTGGCTTCCTCCAGTGCTTTGCTTTTTGCTCACATGTTCTTTCTGACTTTATCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGGGTAGGCTGACACCGCTCACGCGGTCGAACGACCGAGGCGTAGCAGGCGGTCAGTGAGCGAGGAAGCGGAAGAGTGCGACATTTCACCCTCATACGCTCTGTTGTTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTATTCTTTATTTTTTCTACTTCGTGTCTGGATGCTGTTCGGAGTTCTTCTGCAGAGTTCGTGCAGCTTCTCACACCTGTCTCTTATACATCTGACGCTGCCAGTGACAGAGAGTGCGCGCACAGCAATACGTAAC
+
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@ad5884eb-bcfa-4e1e-a156-57791470322d
GTTCATACTTCCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGGTCTCGTGGAGCTCGGGAGATGTGTATAAGAAGAGACAGCCTGACAGGGCAATTGTAATAGCGATGCATGTGCCGTGCGCGAGGCCGCCGGAGTACACATCCTATCCCTAATCAGCAAGCTCAGATTACCAAACAAAGGCACGGCGGCAGTTTTTGGCAGTGACAGTGTTGTCTGACAGAAATGCCGTCAAAGCCAAGCGGCAGAATAGCGGCAGCAAAACAGTCCGAAAAGAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACAGAGAGACGGAGAAAACGAAAAGATGAACAAGCAGCAGCAAAGCCCGTACTCAACATGGCGGGATTCCGCAAAAGTCAGAGCCTGACGCTGCTCAGAAAACTGGACGCACCCGATGCGGCGAACAGGCTGCCATGTGGCCCGAGAAGCTGCACGAACTCATAAGAAGAACTCAAACACGACATCAGACACGCTTTGAAGTAGAAAATAGCACAGAGAGATAACGCTCAGGACAGGATGCGGGTGGCTAACAGGCGTAAGGAGAAAATGTCACATAGAGCGCTCTTCCGCTTCCTCGCTCGCACTGACTCATACGCTCGGTCGTTCGGCTGCGGCGAGCGGTGTCGCTTCACTCAAAAGCAGTAATACAGTTTATCACAGAATCGGGGGATAAAGTCGGAAAGAACATGTGAGCAAAAAGCAAAAGCACCGGAGGAAGCCAGCGCCGCAGGCGTTTTTCCATAGGCTCCGCCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCAGGAGATTTAAGCGAGGAAACCCGACAGGACTATAAAGATACCAGATTGTTTTTCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCCTGCCGCTTACCCAGATGCCTGTCCGCCTTTCTCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGGCAGGTAGCCCATCTCCAGCGGTTCGGTGTAGGTCGTTCACTGGCTCTCAAGCTGAATGTGAAATGCACGAACCCCGTTCAGCCCGAACTATACTGCCTTATCCGGTAACTATCGTCGAGTCCAACCCGGTAAGACACGACAAAGCGCCACTGGCAGCAGCCATTGGTAAAGAAGTCGATGTGCGAGAGGTTCAAGAGTGCGATGATGGCCTGACTACAGCACTGAAGAAGGACAGTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTCCCAGCTGACTTAACCTTCGATCAATCTCCCGGGTGGTTTCTAGATTTTCAGTTTGCAGGAATTACGCGACAGACACAATAATCACAAGGAGAAACTCAAACAAACTGGTTAAAATCAATCCAAACAGGACTATAAAATAACTCTTATTTTGATTATACTTCTAGAAAGAAACAGTAGCATAGTGATGCATAAATAAACATTTATTACTATGTAAAACGTAAACAGAGAAATGAGCAAGTTCCAAACATGATAAAGATATCCACTTAAAAATTTTAAGTGTTTCAGCAACAACTCTCAACAACTAAAAACACCAAATGTAATATCCGGAAAAAACAACTTTGGTATCAGTATTAGACGCGATATTTTCATTTTTATGACATCGCCCAGCAGCTCTGTTAAAAGTAAAAGCTTTAGAAATGGAAGCATCTCTTTTAAATAAAGAAAACTCATTTTGGGATAGCTATTTTTTATAACGACAGGACACATCAAAGAAATGTCATAACAATAAAGAGATGAAAGGTCAAGTAACTTACAAAAATACAACGATAGATAACACACAAAGAATATGATGATCAAGCGTGTCCTCAATGTTGAGTCAATATTATCAAACACCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAAGGGGAATGTTTTAATAGTTAAAGGTTAGTGAAGCACAGAACGGAAAAGAACACAGAAGAATTGATTACTATAAAAATAACACAAAAGCACAGAAATAAACGGAGAAATAAAACCGACTAAAGGTGGCTATACATGATTCAAACCGCAGCGATAATAGCCACATCAGGAAACGCATAAACAAAAGTAACGATAAAGCAATATAAACTACCTAACACAAAAAAGAAAAGATGGAAATAATAGACAACTAAAGAGAATGAATGTAGAATTAACGATATTGCAATAATAGCAACAGATCAAGAAAACAAAAGAGATTTTTTGATGCTGGGGACTAAGTGAATTAAATGAAATATCAATACTTGGTGAAGGAGTAAGCAGAGCGCATCTTTCGATAGCTCAAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAAATGTCCTGATTCATTACTCAGTAATCAAAGATATGATCAACGCTTTGATGCGGAAGCAAGCAAAAACCAATAATCAAATATTTACAGCAACCACACAGCCATGATGTAAATATGTGCGATAAACAGAATTAGATGAAAAAAGAAAAGAATTATATCTTCCATAAAAGGCTAGGAAGAGACAAGGAATCTCAAAACCTACAGCATTACAATTTAACATGGATGATTTTCTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGGAAACCGAGAAAGAAGCTACAAATGAATTATAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCATTTACAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAAGAAAGTATATTCTTAATCGATGCCGAGTCTCACCTGCTCATCTTGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTCATCCCACACCAAGCTACATAATGAAATAGCCATTAACTAGGAAGCACAAAGAAATATCTTTCTTTATCATGCCAGGAAAAAAAAACAAGAAATGGCGCAATGAAGATCTAATCATTGCTCACGCGTGTAAGAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAAGAATCTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAGAAAGCAAAGTTCAAGTTTACCTTAGGTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAATATAAAACCGGTAATGCGAAAGCGATAACTGCTTCAGTGAGATAAAGAATTTGCTATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACACCCGCAAGAAAAAGATGTTTACCCCGGGAAAACGGGAAGGATCACCGTCAGGATCGTTTTCAACTCGCGCCAACTATGCATGAAAGCAGATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAGAGATCTGGATAACGGGGCACGGTGATACTCCGTAACTTGATCAGCACCTCCGCATACTCCTGTCACCGAAGTACGCTTGCGTCGATAAAGAGTTTTTCTGTAACGCCCCCAGTCATAACTTCTTTCGGTACCCGATCATCAGTCGGTGATTCAACTTTCTTACCGAGAGCTGCCGCCCGTAAGAAACGAAGCGATCGTACCGCATTCAAGCAGCCCTTTTTCTGATTTCCTGGTCTTCTTCTGCCGTCAGACAGTGAGGCGACTGATAGCCGCCTGCGCGTATTGCTAGCCGTTTTGTCGCAAAAACATGAAACCGTATCTGACATGGGTGTCGGGGCAAAGCCTGACCAGACGTGCGCAGCCAGCGTGCATGCGCGCGAACAGCGAATTACATCCTCCTCTGCAGCAAGCTCGAATTACCGACAAAGGCCTGGCAGTTTTTGGCAGTGACAGTGTTGTCTGACGAGATGCCATCAAAAAATAAAGCGGCAGAATAACGGCAACAAAACGGTCAGAAAAGTGGTACATGATATAATCACACAACACAGATGACGAACAGAACGGAGAAAACGAAAAAGATGAACAAGCAGCAGCAAGCCGTACTCAACATGGCGGGATTCATGAGGAGTGAAACCTGACGCTGCTCGAAAAACTGGACACCGATGCTGACGAACAGGCTGCGCCAGTGTGAAGCTGCACGAGCTGCAGAAGAACTCAGAACAGCATCAGAATACGCTTTGAAGCAAGAAAAGCCAGCACAGAGAGATAACGCTCCGGGACAGGATGCCGGACGGCACAACAGAGCGTGGGAAAATGTCATAAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTACGCTCGGTCGTTCGACTGCGGCGGCGGTGTCGAAAGCTCACTCAAAAGCAGTAATACGGTTATCCAGTCGGGGGATAAAGTCGGAAAGAACATGTGAGCAAAAAACAAGCACCGGAGAAGCCAGCGCCGCGAGCGTTCCATAGGCTCCGCCCTGACGAGCATCACAAAAATCGACGCTCAAACCAGAGGTGGCGGCAGCAGGACTATAAAGATTACTACAGGTGTTTCCCCACTGGAAGCTCCACTCATTAAACTCTCTGTTTCGGCCTGCGCTTTGACACCTGTCCGCCTTTCTGCCGGGCGTAGCGCTCTCGCGGCGCTCGCCTGCGGTATCTCCAGTTCGGTGTGGGTCGTTTCCTGTCTCCATACATCTCCAGCCCACGAGACCAGGGAGTGCACTTGCCTGGCAATACGTA
+
())$&+---,%'46/4.<?9*4')*).(*+((.'((-,&'/62??8;;>5834&0*&6','-7=I:@=1//')%$$'+.487-55:>3-&3/9:13150,=?<?88**51:.-,($%&($&3/-+%1-,-'%&#$$%,%($32))/+%''('&%$'@=@F686B=3),26:4.4%%<><<(29996..,&*(&+5:;:7,+*+'7?>4/:A<;C@=A<99<((/1;688-,9:=?20,,$&371328239-9%5,2+>&<BCEE:1=$$5,,04'$&&+664;@=7=<>2)811/9<?;>@@=;=<A??BD?77E852/*,'695854.AD=<774/()36,,3@?C9;8:,2(1*+'+%-(&&&&&/569;A62@6:?4+4%5)*>A76:=2<-.5:99E>C87B'%,5%%356+=AAB41(+.444&&8*+&+6((1-(5487),/+*),)&%$$-,$)+)-44,7;325920$$**07494;439',66.1=EG-*E23=4@=<=BD42+1;;32=;=84017=;;<&*0220221-:636,CE:6BIAA,5&)'%#$$%$$%,)*0)'--+652;37>336/&'$#*'$597581#,89449:35;<9B@A%%;B@ED?*.#%'9=DCA?E=@?E50$%5407,020,9>2872()'&&(53AA8=;402-$&*%)*,)&;00)($.$2375-%@$+>>BF@GH>2(2+/.2**=93=?>;E>@=GGA757;-.%$&'+128;664*129;;5857;-*+,-3//9;98453776><47;?FC;,%0*/+)+A73715;;7:>522,-$$'-&'$%'$%$$$$$&($$&'$'$%).*?@A<>2+::4/6:7:;0.;42801*%%+7::CAC<=710462-,>?;D>?4,;*96?D6?,:@@>=<D@>>;=/.-@@&$(+&$5'$(+,)((./34B/1.(2?>D6?<4E.24A@DD=D9;>&$*,<3+?-)1(5-.$*+/2-&%$&))$'''(//2)$,#$*&+/1.++B8-&543:9@)/$#&$&(0&*545)6-,$%$$#&&'%%%&&'))'2:==9D72.+&,)&%%&'$#$(##%&*08++;$'))*(2<::(%.&#5&&>()':9%--*,)><8>:0332022547*63.*'&*11-0399=9<;00%)&%99>6-&&%%/.-)*4;@*2''%&$%%$(&:%%8/1576;765*,*)*/88:::'*''634396:C16%-*<7.866>;15,,'('/,)431(&&'(-1323**-1><-/+0&).5/-0+,,+.-102-(.$%&,-*0-(-5?58==-)'&*)15;2*'8/51&$&('%+)*$#%$*'''%(&%'$$$**%'%)%&+()(--&1,4%*(&57327.040129@;>7=++:::1>=;9==@B<8:1;%$%$%&)-49:>86/=@@>=346-&<4>.4/@E=05()*(&(()%72665;7=7:80-.'%%$%%+,0424=<;66.0-322/3,,*(+%)%%*'&%.,-2,.$%/000+,)(&**,&:66226($$%35474*973$%',,+1((%$##'$'(5:.19')/+0.2:;A>76'#%)))%'+&,&4)):.0.0?>>>789%%46(*13-4.';65;=493//01*(***/$&#&:74:;:5'(((%$&&*''*&,0:?5@AEI=24?;=DFBEJJGCB&)D?%&5<0?D?@B7A@A&==A9DF3&;7<-49?568=:/234($466;DBKF=522..)%'&$.9=9;?969FI-16CB2.%.4>?CBBDD//)'+013--9123+2'((-++%%&((4553-**%$%((+).013.3(539967&$$$(&()%(&,*-'()48D<33;2@88227/(&4-;872299<9:=>A<8<=&.3>6692432:BE@IG0/?38?@7*3(?>;=-'8;C=>@?A?AF<$%%'*)-:<&+89./$//--$)**76<??-208'''&%%#$&',-$.*44(($()3411.2<?>>@@:36@A-&$$$$,*2;9=<?:?96=)-+=?BG?>./,212;<.&)4$)440,(&$'&$)/.%%)6818789=?<(())%/155../4**(..*%%6635,+-/)&%$&&'&%-..+$-&&$##.2678'0+22'$55IK=2*&,EF>-$?>(*;B@<1/,&&-(&&#%.0&)*)33-%%*%$&&&())'((+')&##''6446))(*%)$$+,*5/5*+$'100412'%'2):AB?A7.%&$$%'$(/%/).%%(>>=A>@>?;.)/,132,-$'&&'((.06((*5,()/00&**(&'-&%%$.(472&&*+&()*)+*&.%(%-'2/.02'),)739<8==<?@CB5670,(*$&+.)./32$$&-0..0D=>BDAH5.4@AB<==>.3=>;;9,&<8751244/-,1&%$'#($0#$&*')27/--C@9C@:9352439994*9&5+,&,$&&''*))$'(&*$$)*'-.-.8//+/.48/1&&(//8=9B>88HP6/'%8.)($))+241/+*&&(+((120$&%51-3476194?8BA.106.30*36<:64)+)*#$-(),<@@=A?@AG@D9<@8;46<<98@CD)90:?>::0<=F?C@A780.,2/69<?'=?;?&(%(;=:44':?1%+)$$(&&',+)&&&'('/88.19=:>>JF<9E+((698@?>44./'%<AD/4*(,(#%#''#*59<<<-&434/E@A:7::;3>9;?;;>>DA<DD@A<@C<?=IOJFF@>ACB=>34&%1412(.599?BJB9BC465223:7<06,=?;FL;2-/2-,'%*;?LMJ>BEBCAM87&)('&'8;>>EGAAG;8+-+'(%$&%%$%&'+$#$$(+)*$$%$$',./-,-2-*+45;7:%.=:;5681311CG::E:98<>>61-&555122//.<<++85('**0/.$**$+'&/00(*<79328<=A=-,%$$$&$*.5A<A?*$'9:::45GHF>@BC@>=686</8*87?WRNCA>7388%/,+$&25%3567%%/32'(*/4:<>AE@@F<4136/7((./.83&<.8==@@A;116?B@?CEC?658;ACDDEEBE<>B@J?3567&-:9>>$+--4;:<8.7&)7AB119/395=2380007<C94''0A?BEFGE:AD<=<0+,E?@9<55'&E=866/9<<=4740%'%.--47878/-21.<47/,)&$)-0=8932;@==:<?@@A@F*;,00/79:%89-.../*'&&%%$&(0-,$%'(+.7<81<>F?9A>HK6&4=CBB,,+/58?@7BE?./;,86796=A:<><4<F;HHJE:B64*+9=BEHEIJ@>IM>A<F>@;=:9;;/BDDAA?C12'03444'%***.3*1:;==>A,,112?B-*7=?A@=B:7=CA@8?9><:6<9:BD=0B;<3*(&%%22*)(*%(,6>8.(B?9*/')1@69(0;44*;3()#$*):2+<C<6?:FAF22&&&'-))&&&##$+%'+6.1032134((85'-0.-*/%'))57<<49::6)69;=?<8@6<A>?748:?;;E?20.-&&:>C?<=*:4;+.3.1'9?BB<BB.<;2/)')%%*:,773AE@C)25=<3?;;><3-$*16;3,%$#(*84/+;&>?98?8B6942*)87<?,%2#$%$%$&%&0)((+*''7BBB@@A1&'5>@KG=:.**&&86>>>?1624,'>448:@:DB28'.?<ECAB?5C/&5'%%*%'&)'.)('(&&2B@A<@;8754/2<;-5<>HFD84'($&'&(&%%')&'&'$('088G@B:;&+(98<9711233+6$(#*+'-38:<:<>?=B?;6235345***($'))$+7@EB:;CA6/,588AAFC;?37.'''$%(&#%(;>>LI4-9$$,--0-.$%*''%%+(<2/,+:3/:>495B3.?+0>66*,+,436=5.2-*%)(-*&%)0'''+*;9D;1)%$$&%')'$$&$#$%$$$)%,2&&-'++%)&&$%'(*,':7/&&)04')+2?@@?*/.)/*471.903GE@3<;45780*$,=?IC4/?05.,''/74076839DBC@3&$13/2A>?1/35D?@BC>=9,,66:=-6$(55''3533.>).;.802;>BE@95/7-3>?;<<&:9>A@DC1&%*,++7DD:66,(<AB=((KK75+C9:66>56.*.'0.0<01'7,//(%&.77@?I>AB)/:79=5%%'(&&$%&($-(,.5438-,98=B7,/---,-1>C<6659==G753:5>=9;4-266:05&%%&#%$$+$%*.2,()+1&,**&')**,*..+),,75B3>1@0+5(*$'&(4&&.0-2&(&%'('0*(%%%%,.235550'465/8BGBB?$,$*22.(6A??:34$&'0%%$$('%+3&$230<,/7/1780*$'1533**46D@@>>+?67:=;?:68?;@>@AF?8=>98?:?AF0=%,-2=C7-($$($$#%&#$$$&'$*0%&%%&7::=F;;JJD6*-&><@@??@::D@=442&'$3(0<<@>:FF=72C<CDH3,>*-;>56//.8?>>B>1:')$;3?D>>@7$*3=<B=FE;3*(&$'%$%%79-./0155::6664%7/-)(/<41-79>>?C>:C=HF//BA9<(@@:@'560-..&&'*#*,/72661/11,,-+/'$$"%&/4;:::81211$#+)(,.399:?...4$%%$$$)-.//4+56-&#$%$'&*&&''$%$$%(*%%$$-''(&&'$$#$&$'*12,(91(#&&%.(''**$%(>%$$%&)%(*(',0&,$+,,*)--)3+02+,%*-:+/-0+2-$(++/-5569.1'/AB11136DD=<01(('.>8:-///0+/'&*+,,7754/3
@f936ee47-9da7-4105-8409-e4b2ffd712f4
TGTCTGCGTCAGATCGCGGTCAGCGCGGTGCCAGCGGATGCGTACAATTACATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTGTAGGTGGAGTTGTTTTTCATATTTTTGATATAAATTCATTTATCTCATGAAGCAGTCATCGTCGGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAGATGACTTGAACTTTTGCTTTCTTTTCATTATTTTGATGGCAGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTTTATTTTGTGAATAGATCGTCTATATATCGAACACCTCTTTTCTTACACGCGTGAGCAATGATTAGATCTTCTATTGCGCCATTCTTGTTTTCTGGCATGATAAAGAAAGATATTTTGTACTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAAATATTTCGTGTGTGTGAGAGTATCGATGCTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTAGTTTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTACAATTCCTTCTATTTCA
+
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
@2ca1231f-4d91-43c7-8eac-adb1271c9efd
GTTGTGCGCTACGTTCGGTTACGTATTGCTGCGCGCGCACTCTCGGTCTCGTGGGCTCGAGGATGTGTATAAAGGGCAATGATGATCAGTACTGAAAAGTTATCGGACTGGGGGCGTGGAAAAACTCTTTATCGACAGCGTGTCGGGACAGGAGTATCTGGAAGTGCTGATCGCCTATTGAGATCTTTGTGCCTGTTGTCCAAGACTTACTGTGGATTAAGCGGAGAGAAAAGCTATCAGCAGACGGTGTGAACACTGTCATGGCTCTGAAGTGATCACCATTTAAACAGCATGGCTAATACAGCGGAGCTGAAAACGATCTGGCATCTTCCTGTTTCCGGGGTGAAACATCTCTTTTTGCAGTCTGCGTCAGAATCGTTCATTGCGTTTCAGCCAGTCTGTACAATTCCACAGCGTATGTTAAATTTATAATCTTTTAGTCATTTACGCCTATGATTTTGTAGGTGGGTTGTTTCATATTTTTTGATAATTCTTTTTATCTCACTGGGCTTGATCATCGTCGGTATCAATGGTTGTTCTTTGATAAGTATACCTGTTAGAATCCTGATTCCTTATGCAACCTAAGTTAAACTTGGACTTTTGCTTTCTTTTCATTGGGTAAGCGTAATCAGGATCTAAGGATAGTAATAGCCAATTCTTGTTCTTTTATTTTTATTGAATGGTCGTCTATATATCTAAGCACCTCTTTCCTTTACACACTGCGTGAGCAATGGTTAGATCTTCTATTGCGCCATTCGTTTTCCTGGCGCATGATAGGAAATAATTTTTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATCAGCCAAATCATTTAATGTTGAAGTATCGATCTTTCCGTGTCAGAAAACGATTCATCGGCATCGGTGATTGAGAATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTAAATGCTCTAAGGGTTTGTTTTAGTTTGTCTTTTTCCATTTATTTTCAACACTAAACATCATTAATTCCTTCTATTTCAGTAGATTGCAAAGGAAGTAGAAATCATCTATCACCCCTCAGCAATGGCTGCCTCGTCGGTACATTTTTCTCGGTTTCATTTATCTACACTCCAGCCCATTTCAACTGAAAAAGAAAAGATCATCCATGTTGAATTACATTGCTGTAAGAGTTTGCGATTCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCCACATCTAATTCGTTTTATCGCACATATTACATCATGGCTATTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCGCTTTCTTCTATCAAAGCGTTGATCGTATCTTTGATTACACAATTAATGAATTCCATTTCTATCATCAATAATGAGAATAATTGAGTCTTTTTGAACTAAGATTAGACTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATGTTTCATTTAATTCATGGAAAGTCCTATATCTAAAAAATCTCTTTGTTTGATCTGTTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTGATTTACCTATTATTTCATCTTTTCTTTTTTGTGTTGATAGTTTTGATACGTTTTTAGCTAAATTTGCTTCTTGTTTATATTTCTTGATGTGGTTATTATCGCTGCGGTTTGAATTCATATAGCACCTTTTTTTGGATTTGTTTTATTTCTCAATTTATTTCTTGTGCTTTTTGTGTTATTTTATAGTAATCAATTCTCTGGGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAGTATTAAACATTCCTTTTCCTGAAGTCGGGTTTGTCACAATGGGGGTGTTTGATAATATTGACTCAGCATTGGGGACACGCTTGATTCTTTGTGTATTGTTATCTATCGTTGAGTATTTTTGTATTTACTTCTAACCTTTCATCTTATTATTATGGACATTCCTTTCTTTGGATGTGTCATGTTATTTATAAAAATAATATCCCAAAATGGGTTTCTTTATTTTAAAAGAAGATGCTTCATTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAGGCTGAAAGTATATCGCGTCTAATATCGATGTTTTCCCAAAGTTTGACTTTTTCCGGATATTACATTAAAGTGTTTTAGTTGTTTGAGGTTATGCTCTCAGAAACACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCATTTCTGTTTACATTTGTATTAATAATGTGTTTATTTATGCATCACTATACCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTGATTGATTTTAACCAGTTTGTCGGAGTTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAACCACCTGAAGTGTATGGTTTGGTCGAAAGTTAAGTCGGTTGGGGAACTGCTTAACCAGGTAACTAACCATTGCGAGACGAGTCCGCAAAACTGTCCTTTCCAGTGTGGCTGTAGTCAGGCCATCACTTCAAGTGCTCTCTTGAACCTCTCGCATCGACTTTTTTACCAATGGCTGCTGCCGGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCGGCGGTCGGGACTGAACCGGGGGTTCGTGCACTAACCAGCGGAGCAACGACGACCTACACCGAACCGAGATACCTACAGCGTGAGCTATAGAGAAAGCGCCACGCTTCCCGAAGAGAAAGGCGGACAGGTATCCGGTAGGCGCTTGAGTCGGAACAGGAGAGCGCACGAGGGAGCTTCAGGGAAACACCGTATCTTTACTCAGTCCTGTCAGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCAGGAGGGCGGAGCTATCGGAAAAACGCCTGCGGCGCTGGCTTCCTCTCCGGTGCTTTGCTTTTGCTCACATGTTGCTTTCCGACTTTTATGCGATTCTGTGGATAACCGTATTATTGCCGCTTTTGGGTGAGCTGACACCGCTCGCTTAAGTCGAACATTGAGCTGAGTCAATTGAGCAGGAGCGGAAGAGCACTTCTCTATGTGACATTTTCTCAACACGCTCTGTTGTGCCGTTCGGCATCCTGTCTTGACGTTATCTCTCTCAATGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGGTTCAGTACGGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCAGGTGCGTCCAGTTTTCGAAACAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGAAAGGTACGGCTTGCTGCTGTAGCGTTCCTTCTTTTCGTTTTCTCCGTTCTGTCTGTCATCACCGTTGTGTGATTATATCGCGTACCACTTTCGACTGTTTTGCTGCCGTTATTCTACTTACCGCTGGCTTTTTTGACGGGCATTTCTGTCCAGACAACACTGTCACTGCCAAAAAAACTGCCGATGCCTTTGTCAGGTAATTCGAGGCTTGCTGACAGGACAGGATGTTACCAGATTGTTATACCGCGTACATGCACGCATATTACAATTGCACTGGTCAGAACTTTGCCCCGACACCCATGTCAGATACAGACCATGCTTTATGACAAACAGAGTGGAGTAATACGCAGGCGGGCTATCCACGATCGCGCCCTGTTCGTCTGATGACGGCAGAAGACCAGGGAAATCAGAAAAAGGGCTGCGCTGAATGCATAGATACAATTTCCGGTTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGGATTAACTCACTGACTGATGATCCTGTCTCTTATACACACACATCTCCATGACCCACGAGACCAGAGAGTGCCGCGCGCAGCAGTACCGTAAC
+
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
@ff1fc554-81ba-4dff-a1c7-01eb78a36632
CAAACGTGCTACGTTCGGTTATTGCGCTTGCGCACTCTCTGGTCTCGTGGAAACGGAGATGTGTATAAGAGACCGTTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTCCCGGGGTAAAACATCTCTTTTTGCAATCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCAGTACAATTACAGCATTATGTTAAATTTTATATTGTCTTTAGTCATTTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATGACGCAGGTATGAATTCGCTGTCTCGCTGACGGATGATAATTGATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAAATGGATAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATAGTTAGATCTTCTATTGCGCCATTCTTGTTTCCTGGCATGATAAAGAAAGATATTTTGTGCTTTCGTTAATGGCTATTTCATTGGTGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCTGATCTTTCGTGTCAGAAAACGATTCGTCGGCATCCCGGTGGTTAAGAATATCACTTTTTCTTTTTCATTAAGATTTATGGCTTTCAGTGCTCTAAGTTTGATTACAGTTTTAATCTTTCCATATTTCAACATATTGTCATTAATTCATATTTGAAGTGATTGCAGTAAATCATCAATCACCTCAACGAAAATGACTTTTTATAATCATTTATTTTTCTCATTTTCATTATCTCCACCTCAGCCATTTCAACTGAAAAGAAATCGTCCATGTTAGAGTGCATTGCTGTAGGTTTGAGATTCAAATCTTCCCAGTCTTATGTAAGATATCTTTTCTTTTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTGAACTAAGATTGAGCTAATGAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTTGTGTTAGTAGTTTTGATGCACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTTGGTTATCGCTGCGGTTTGAATTCATATAGCTTACCTTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTTTTCCGTTCTGTGTTTCACTAACCTTAATCGTTAAAACATTCCCCTTTTCTGAGAGCCGAGGTTTGTCGCAATGGAGGGTGTTTGATATGTGTTGACTCAACATTGAGATACGCTTGATTTTTGTGTCGTATCTATCGTTGGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCAAAATGAGTTTCTTTATTTAAAAGGGTAATACCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATGTCATAATATCGATGTTTTCCAAAGTTGTTTTCGGATATTACATTAAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTTATCATGTTTAAACTTGCTCTCTCCATTTCTGCTTACGTTTACATAGTAATAATGTGTTGGCTATGCATCACTATGCCCACTGTTTCTTTTCTAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGAATTTCTTCTTGTGATTATTGTGTTCTGAGGTCGTAATCTCTAAACTGAAAACAGAAAAAACCACCTGGGGAGGTGGTTTGATCGAGAAGGTTAAGTCAGTTGGGGAACTGCTTAACCCGGGTAGCTGTCTTGTGCGAGACGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCGGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATGGTTACCGGATAAAAGGCGCAGCGGTCGGGCTGAACGGGGGTTCATTTTTCATTGGCTTGGAGCGAACGACCTACACCAGACCGAGATACCTACAGCGTGAGCTATGTAGCCACACGCTTCCCGAAGAGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCGAGATCGGAACAGGAGAGCGCGCACCAGGGGCTTCCGGAAACACCACCTGGTATCTTTTGCAGATCCTGTCGGGTTTCGCCACCTCTGGCGAGCGTCGATTTTTGTGATGCTCCGTCGGGGGGCAGACGGAAAAACGCCTGCGGCGCTGGCTTCCTCCGGTGCTTTGCTTTTTGCTCACATGTTTTCTTTCCGACTTTATCCCCCGATTCTGTGGATATAATAACCGTATTACCGCTTTGAGGTGAGCAAAGCAAGCTTGCCGGAGGAAGCCAGCGCCGCGGGTAGCAAACCCGAAACATCACATCGACGCTATCAAGATATTGCCTACCGCAATCGCCTTCGGCGTGGCATCATCTTTGCCAATCTCGGTCGGTAACGGAAAGCAGCCATGCATATGA
+
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
@83766534-07e0-47f2-a178-7e84bd9467c7
TTATCGGTGTGCTTCGTTCGGTTACATTATTGCCAGCACTCTCTGTCGTCGGCGGCGTCGGATTAGTAATATGAGACAGATCAGACTTATAGCGGATAAACCCGGAGAGAAAGGAAACTATCGAAAACAGACAGGCGCTGGAACACATCAGCTCCCAAGTGATCACACCATTCGCTTTCATGCATAGCTATGCAGCAGGCTGAAAACGATCCTGACGCATCCTTCCTATTTTCCAGGGTAAAACATCTCTTTGCGATCTGCATCAGAATCGCGCATTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTGCAAGTATCTTTAGTCATTTCATATTGATTTTGTAGGTGGGTTGTTTCATCTATTTTTGATACAAATTCTTTTATCTCACTGAAATGATCGTAATCAGTATCAAATGGTTTGTTCTTCATTGATGTACCTATTCTAGAATCTGATTCCTTATTACAACTAAGAGTAAACTTGAACTTTTGCTTTCTTTTCATTGTTTGTTAAGCGTAATCCAGGATCAGGATGTAATAATAGATTCTTGTTCTTTTATTTTGTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTAGGCAATGATTAGATCTTCTATTGCGCCATTCTTGTTTTCCTGGCATGATAAAGAAGATATTTTGTACTTCCAATTAATGGTATTTCGTTATGCGAGCTTGGTAGGCTGAAATGTTGTATGTTCAAATGTTAAGAATTATCGATCTTTCCGTGTCAGAAGAGCGATTCGTCATCATTAATTAAGAATATACTTTCTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGAGTTTGTTTGGTTTGTCTTTCCATTTATTTTTCAACGTATAAACATCATTAATTCCTTCTATTTCAAATCTAGATTGCAAAGTGAAAATCATCATCACCCTCAACAAAAATGACTTTTTATAATCATTTATTTTCTCAGTTTCATTTATCTCACCTCTGACCATTTTCAACTGAAAAGAAAAATCCTCCATGTTAGATTGCATTGTAGGTTTTTGAGATTCATACATCTCTTCCCAGTCTTATGTAAGATGCACTATCTTTCTTTTTCATCTAATTCATTTATCCAGCACATATTACATCATGGCTGTATGTTGTTATAAATATTTGATTATTATTAGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCTCATCAATGAGGATAATTGGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTGCCTCCCTTTGCAAGCATTGATATTTCATTTAATTCACTTAGTCTATAAAAAATCTCTTTGTTTGATCTATTACCACTATTATTACGTATGCCTCGTTAATTCTAGTATCTATTCTTTTTAGGTTGCCTATTTCATCACCATTTCTTTTTGTATTAGTAGTTTTGATGCGTTTTTTATCATTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAGATTCATATGGCTTACCTTTTTTGGTTTGTTTTATTTCTCCGTTTATTCTTGTCTTTTTGTGTTATTTTATAAAGCAATCAGTTCTTCTGGGGAGTTCTTTTCCGTTCTGTGTTTCACTAACGCCAATCATTCTAGAAGCGATTTCCCCTTTCCTGGGGAGCCAGGGGTTTGTCACGCGAATGGAGGGTGTTTGATAGTATTGACTCAACATTGAGGGACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCCTGACCTTTCATCTCTTATTTATTGTGGACATTTCTGTGGATTATGTCCATGTTATAAAAATAGCTATCCCAAAGAATGAGTTTTCTTTGTTTAAAGAGATGCTTCATTCTAAAGCTTTTTACTTTTAACAGAGCTGCTGGGTTTTTTACGTCATAAAATAGAAATACTCGCGTCTAATATCGATGTTTCCCAAAGTTATTTTCGGATATTACATTAAGTGTTTTAGTTGTTTGAGTTATGCTCTCGAAACATTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAAGTAATAATGTGTTTATTTAACCATCACTGCCATATTTCTTTTCTAAGTATAATCAAATTATTGCTTTCTGGGTATTGCATGTTTGGATTGATTTTAACCAGTTTGTCAGGAGTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCTAAACTGAAAACAGAAAAGAAACCACCTGGGGTGGTTTGATCGAAGATTAAGTCAGTTGGGGGCTGGCAACCGGAGTAACCATCTTATTGCGAGACGAGTCACCAAAACTGTCTTTCAGTATGGCATAGTCAGGCCATCACTTCAAGTACTCTCTTGCCAGACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCGTATCGTGTCTTACAGGTTGGACTCAAGACGTAGTTACCGGATAAAGGCGCAGCAGTCGGGACTCAGACAGAGGTTCGTACTATTGACTTAGAACTGGGCGACTTCCTACACCAGACAGGATACCTACAGCGTAAGGCTATGAGGAAGCGCCCACGCTTCCAGAGGAAGGCGGACAGATTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGGGGAGCTTCCGGAAACACCTGGTATCTTTATAGTCTGTCAGGTTTCGCCACCTCTGGCTTGACCCGTCGATTTTGTGATGCTCGTCAGGAGGGCGGAGCCTATGGAAAAACGCCTGCAGCGCTAAGCCTCCAGGTGCTTTGCTTTTGCTCATGTTCGCCGACTTTATCCCCCGATTCTGGATAACCGTATTACCGCTTGCCCGGGTAGGCTGACACCGCTCGCCGCAGTCGAACGACCAGCAGGCGTAGCGATCAGTGAGCGAGGCGGAAGAGCGCTATATGTGGCATTTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTGTACTGTTTTCACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCATTACGGCTTCTCACATGGCAGCCTGTTCGTCAGCGTCAGGTGCGTCCAGTTTCGAGCAGCGTCGAATCTGACTTTATAGATCCCGCCATGTTGAGTGCGGCTTGCTGCTGCTTGTTCATCACTTTTCGTTTTCTCCGTTCTGTCTGTATCATCCGCGTTTGTGCCAGTTATATCGCGGCGTACCACTTTTCGACTGTTTGCTGCCGTTATTCTGAGCAGTACATGCT
+
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
@10dbc323-b02c-4e5e-9a75-6a7d3c3fdb2a
AAAGAGAGTATATTCTTAATCATCGTATGACGAATCGTTTTCACGGCTTGCGAGAAGAATCGATGAGCAACATTAAATGAGCAACATTCATCACCAAGCTCGCGTAATAGTAACCGATAACGACACAATATCTTTCTTATCGTGCAGTAACAATAAGATTGATGTTGCGCGTGTAAGAAGAGGTGTTTGGAGCTCTGTAGACGATCTATTCAATAAAATGAGAACGAAATCTATTATTACGATCCTGATTACGCTTGCAAATATTGAAGAAAGCAAAAGATCAGTTTACCTTAGTTGTAATAAGGAATCGAACTATAATGAAGAACAAACCGATACTGACGATGATACTTCAGTGAGATAAAGAATTTATATCAAAAATATGAAACAGCTCCACCTACAAATCATGTAGTGACAAAGACAATTACAAATTTAACATGTGCTTGTGGTGTATGCGGCTGCGCTGAACGCGATTCTGACGC
+
+6*.+&$%&,43574,/448<-2+&$$&$++%*)$'*-0./(%(&((()&&)&%*,+**1732,)+$($$:-.05683+*)**&'',12249,/1()*-.3)*$$%))'&'$$%&$$)'(&$&%%&'.1<;<<>?;85.33$'&'#(+$$*#$(&&'$$$$'&$15$+,41923'('/'&),61110,*-'(%)$%%*.69:443978:71&*-%&&2+$&*9:+'&.7773/96./1+,,,$$%987>1+:+*76)2/0+&&$&.-%%)()&)%(&%'(((%%*.0(#'#$(,%)$%&++-,-2$-02*)+'))(+-0/,-114810./3&&'$%'0-55973.&%%(*,%.02.&2*674'+<CFCA>75?24++1/2-0+*))*&4403,+)$(#,/5560))$&#,.-,+,).*1%'%'$&%*27<;433)('$&#$(&&#$7&(%$#&#$%&'3;>BDBCG>BA>>36*++*)*
@1cb2755f-2d9d-4285-93c3-3658ffe5eac9
TGATGTTGCTTCAGTTACACGTATTGCTGCGCGCGCGCACTCTCTCTGGTCTCATGGGCTCCGGAGATGTCAGCAAGAGAGACAGCTCTTGAACCTCTCGCACGCATCGACTTTTACCAATGGCTGCTGCCAGGTGGCGCACAATATCGTCTTAGCGGGTTGGACTCAAGACGATAGTTACCGGATAAGAGCGCAGCGGTCGGGCTGAACGGGGGTTCGTACACAGCCCGGCTTGGAGGCGAAGAACTGACCTACACCGAACCGAGATACCTACAGCGTGAGCAGAAAGCCACGCCCGGGGAAAGGCGGACAGGTATCCAGTAGGCGGGTCAGACAGGAGGCACATTTCAGAGTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGGAGCGTCGATTTTGTGTTATATCGTCAGGGGCGGAACCATGGAAACGCCTGCGGCGCTGGCTCCGGTGCTGGCACGCACATGTTCTTTCCGACTTTTTATCCCCGATTCTGTGGATAACCGTATTACCTTTGGGTGAGCTGACGCAGCTCAACGCCGCGAACGAGCGTAAGCGGATCCGGTGAGCGAGGAAGCGACATATGTGACATTTCTCCTTTTGCTCTGTTGTGCCGTTCATCCTGTCCTGACGTTATCTCTGTGCTATTTCCCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCAGTTCGTGCAGCCTCTCACGGCAGCCTGTTCGTCAGCATCAGGTGCACGTCAGTTTTCGAGCAGCGTCAGGCTCTGACTCTTTATGAATCCACCCATAAGAATTACGGCTTGCTGCTGCTTGTTCATCTTTCGTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCGGCACGACCGGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAACCCCCTTACCGTGCAACTGTCGGTAATTCGGGCTTGCTGACGGACAGGATGTGCAACTATTTATACCGCAGCGTACAATTGCCGGACTTTGACACCCATGATACGGAGCCATGTTTTGCGCGACAAAACGGGGTGGAAGTAATACGCACGGGCGAACTATCAGTCGCCCTGTTCGCCAAAATGTTGGCGGAAGAAGACCAGGAAATCCGAAGAAAGGGCTGCTAGATAGGCAAGACCGTTTCCGGTTTTTACGGGTGACAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATAGTGGGTACTGAAGAAGTTATGAGACTGGGGACGTTACAGAAAAAACTCTTTATCGACGTGACAAGCCGGCTCGGGGACGGGAGTATGCGGGGGGTGCTGATCGCTATTACGGGTATCACCGTGCCCTGTTATCAGACTTGCATGGCGGATTAACTTCCCGGAGAAAACTGTCGAAGCGGACAGTATATGAACACCGTAAACTCCCCAAAGTGATCACCATTCGCTTCCATGCATAGCTATACAGCGAGTAATGATCCTGACGCATCCTTCCTGTTTTCCCGGGAGTAAAACATCTCTTTTTGGTCAATGCCGTCGAATCAGTTCAGCACGCGGTCAGCTACGTACGAATTACAGCATTAAATTTATCGTTATCTTTAGTCATTGCATGATTTGTAGGTGGTGGAGTTGTTTCATATTTTTTGATATAAATTCTTTTATCCTCACTCAAAAACAGTCATCGTCAGTATCAATGGTTTTGTTCTTCTTGGTATGCCTATTCTAGAATCTGATTCCTTATTACAACAGGTAAACTTGAACTTTGTCTTTTCATTATTTGTTAGCGTAATCAGGATTTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAGATCTATTGCGCCATTCTTGTTTTTCCTGGCATGATAAAGAAAGATATTTTTGTACTTCCAAGAATTGTGCTTCATTATGCAGGCTTGGTGATGAAATGTTAAGCTCATTTTAATGTTGAAATTATCGATCTTTTTTCCGTGTCAGAAAACGATTCGTCCATCGATGATTAAAAAATATCAACTTTCTTTTTCATTAAAAGACTCCATGCTTTAAATCTGCTCTAAGGGTTTGTTTAGTTTGTCTTTCCACCAACTTCTCAAGCATCTAATTCCTTCTATTTCAAGTGAACCGCAAAGGAAGTGAAAATCATCATCCTCAACGAAAATGACTTTTTATAATCATTTATTATTTCTCGGTTTTCATTTATCTCACCTCCCAGCCGAACTTTCAGCTGAAGAAGAGCCAATCCATGTTAAGATTGCATTGCTGTGGGTTTTGAGATTCTGACCACCTTCCCAGTCTTATGAACAAATCTTTTCTTTTTTCATCTAATTCGTTTATCGCATACATCATGGCTGTGTGTATTGTTGTAAATATTTGATTATGGCGGTTTTTTGCTGCTTCGATCATATTATCTTTGATTGCTGAGTGGCTTGAATTCCATTTCCTATCTCGTGAGAATTAATTAAGGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCCTTCTGCTTACTCCTTCGCAAACATTGATATTTCATTTAATTCCATAGTCCTATATCTAAAAAATCTCTTTGTTCATGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCCTATTATTTCATCTTTTCTTTTGTGTTTAGTAGTTTTTGATACGTTTTTTTATCGTTATGCTGTTTTTAGCATGTTTCTTGATGTGGATTTATTATCGCTGCGGTTTTGAATTCATGCTCAAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTAGTAATCAGTTATATAGGTTCTTTCCGTTCTGTGTTTCACCTGCCCCAATCATTAAAACATTCCCTTTTCCTGAGAAATAGGGTTTGTCACCAAATGGAGGGTGTTTGATGATATTGGGCTCAACATTCCCGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGAATCTTCTGACCTTTCATCTCTTGTTGTTATGGACATTTCTTTTGGATGTGTCCATGTTAGCAAAAATAGCTATCCCAAAATGGGTTTTCTTTATTTAAAAGAGATGCTTAAACACAAAGCTTTTTACTTTCCATAATGAGCTACGCTGGGTTTTTACGTCATAAAATGAAAATATTATCAGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTTCCCAGGATATTACATTAAGTGTTTTTAGTTGTTGTTTTTGGGGATTATGCTCAACAAAAACAGCAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTTTCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTACATGCATCACTAGCCACCCACTGTTTTTCTTTCTAGAGAAGACATTTTACATAATCAAAATATGTTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTATTCAGTTTCTTCTTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACGCGAGAGAAAACCGCCTGGGGAATTGGTTTGATCGAAAGTTAGAATCAGTTTCAGGGGGAACTTCGCTTAGCGAAAGATGCGGCATCTTGTGCGAGACAGCAGGTCAAAACTGTCCTTTTGATGTAGCTGGTCAGGCCATCACTTCCAAAGTACTCTCTTCCTGTCTCTTATACACATCTGACGCTGCCGACGTAGAGAGAGTGCGCATATGTATTGCGTA
+
$/%%$$%$##%/%)22(('.)/-.05;<*7)%)(''$'##,*2$3D;7967'5%'(-;;<(8053:65,'(($$&'+*&0(59:7?@?<899>?A6&,8./-.'-9=4DACQNKFBAAFED;='&)))()/'',>9;?53$*)($$,0/$$$'$%)17B?;8;@@C7129?@BA?;D@@:EA485+*+)#.:)=88;81&/*-.3-87:4'(/)<41&(&$8430-%$#)0344150%60&&%$+0&&;++',.;((*''+,*1..B<;65/5CAL?)'*&'(&&+(+.'*(,'$'(&*2+&*'-8?CGB*,43*&,,0#.&&&--&'4*3+.+&$/2'$0*%.0-/&.''%',-136=A@@@D<7>452323<,0CCA781102$(08+&(##$,*$&*'.,57<17;=<-)$*&(&%%&38/&;5959/2($&&*-01-,12(('$)+)*3%%//,(&$6,,/%$5,*)($$1*/-,&35657:=56,34465991121099D?C>;0,07256>;5>=.274+#$$%'2)-'?423,($*%$#$(()....%(%%+'%$(&$%$%'-%''''5$,+*'')+&,-&'+%,&&%7979:8/)%'):695=52)(*)+98222%(,.+:==//00481%%+'&%3405=9</7.//351.028+48ABC=>;;@>?9=>/''/354?A>.1+DD?6;=@>4.+25/,)3')(&%'63.<'0%(//,1-'&*/22)62492.26@;?4&$++%6.</7K;8<9809*<9346;>?=@?J?BGBCB;85)(3446%)54(&%&$%%%.--,1223:8484=7...+890(=<C@C>>DB?AF8=ACAD?=8=?>=3.?BD>B<GB6?678;==,1/59<<?>?;=?@?4;96>989GC60/6=><HA799818895123//$..,)**&$%&)1:.04.:.-,/(*,7459;AD:59,)&%$(553107...,,,.35-8),$$$256D36=9<97>$')%%):;AE22&,53.6<+(%%#%###-,3452..8/0'%*+&%$%%%#)&&($''##$%)&&&)*))**%'():<:8=*-577752(&$$06;021.-'()3A8;6':B?@@?@*-#%)*6))$$+0+(3+1:<5GI=<<36*$#%,,$''($$&''%(+,)1*:B63/2.&':,,4,&-,((-'):=><8-%+(')-3:9::?--'46=/4+/45I?6',$)'$'$*)/9>9+0%')..$&&%*10)).73#'*.115&%&%$(*/7656)254%0+@?;+&,'+'*.(,(+#'1..)*,-,9@@BH@D>3337=68.,$$'%,%&(&)#%#)214<CDC%,:&8>>$$++0---562>6?1':$$-,-203405:71=/..)>/?A?BBC@3':.8=887##%$&-9/53>?-,##$+18;30.$*GF=>639-,*&(',8)'*;:>%:10556:3,.//$'(+---')&-D>50=1124>:5&'01-1+)**:4285,$#%,+0/&$(&(%%+,45=761,%%%.26778;B>@=PI/1>*,+%),3494904682)))))%&%$&'')'('*())51/$&:59256&&)*'**.0%#%$&))*%&&)+164=/<////02282'%%&&('%##&;6:%%$$)(%$&'&67:.--0)8/&*.1,3884?B<DAFDAALJD>==A@AEB<>>;B@F>>..8-&$&1+$(*(&'010@A;==<A:AC42A<??:=BEKB8A;:;3*..%'33/2CCICD9:/3((*69>??C34656501*+$%#&#%557-++.224,45&#)%*9ABD@FE986,0,-+(,*304,<64=6686./.<?<669>?>@:106;=2/DACF>JDG?;=@HF<DEBBHD;:7277<<7A8BB@99ADEE<=779,,322/075<:>=7743642/+(,6743;591)66+***-<?@CLJA?@MB0$*'''')*488AA?&4@52D=8>7@@E430457,0$%'$$$+)1*&'&36?>35:7**56652487=.<+0C3368453=<>>DED@AC<>A6314117/+/'58:DBD=778=:B,(8+*3/DA3:133.-)(.)269A??<?758+))(*+%$%%/:<G=A621+&)-09:5-5>28%*/)((),1-.+&$#&.,?+;<33=CAD6A>.%6@HK=<>>:9).$$'%%"$$$%&-/&7305(/4/7;;?25'6;<F?*+(5-+.(+))),%-*''--+1))+'%.:=;&&/)3332/87;://:<>?CCCDF>1'05697001-><@A5A4;CDL4279::736&/&')2)7,*))'&&'(792.5(314/((4/(+%&'$&+,.;<=D?&'(((5799<7-/+,3(06.20/*$-,42-,-&&$$$%%-'*+++=?A8*&&%+%#$(**59A::?=>;5,-.,;0::7;94=><6-4''&##$10;/9%(**+/-.1-%>A4;<8F>@<CBB@90.%'$)&',8:D>JHAC68:<))*(&'4A5<<%%:;>B>9DB?A')%''01%$##&'(-??47766A22=?69</)(((('($&/0/.(+,7/700/6.::B>@CDEAH56*000*).''3(-2+*)(*(.48(,4566?6==46&,34$549<>=>:E?E=;AA0,-%(*+%>=;33572@0,/%89;;<<774018<922'&%&&448/88&7126/(-2(&((9<8;<GE;4A87&,+.5/)/27546::90%)8/7:=821674*35259=@EFOI8EEHE<DBB>,$$..?47DA8:389@;D?@=<8)677//+$&#%3.3:><4+%%?>ADECADED=<9?'0%531,064.1*/4-:9>BDE//%39)4%##"#&&'%&&&---+29<42<EEF=A>F?>DH>=C7:7?>13,2C:@?1?3113D>G:BA990;>@@2//<<8/-.(*,&&$($.1:.&)'''*.7:=6<99<=*0&&&(#&'&)<:65:>>CEIHBA??36*&7CD344*)&%+'$%&-7EEK;98''814C>7;:&'BBDFGA<::86/)))&**69:550100%''&)9AB<@64,,3A@ACD@2234).*'099.'0/C=<4B2=);99<;;:4'##'*+0:-C@=A8;@;8-/)240&+,$./,-'-E@@ABA<>=:0(-=;;<855>611=2%/.&*(79(:%/;A66@@HI@C;%&=@<84/26;<BBCHPD)))%$6-%%+$$(((*-/42<==@>/'&'''$,-2342%%'&)"#&%&%*ACBNI?C;89?5@@B98/,.-.,)(,.514*7:<=>8>DC>:;8<6398?=157;<6??<)04?.()++-:<EFDHGGDDB@34,?==>GC5-9-..%%%<;CA8#%%7$/43$$%',%&)%(('$(&%-136&<>=;/0+3/1@4B9:EDF8.43464<;5@CB@A=($$(4-5$8030@BA?><A@;&%%15501BAB81=BA>A<<;9AC7--,#%%$#<>894.+2/1.&&-/03:2=>F@B=A<0)*''(%&+'%&&"%''##%#2428;>:;(0((01.-/28;BEC;<>885745:<GA=875,+++(-77BF6..-'&(57D6GD8BA6%''&)/((+,-,46:51,%6&/:92430.7;=.--)-,+()#%%%%.%/*<3.1$))2$%)))'$.6:685..9?--++2-/;%))/)&.,*($'*)-038=(((*('+++*($'&$)%'%+',;7<@@;*;3-1*2($%$%%&&*%1398=@>((1)/1/1/3.+(,*../963::;:61>,,99&())&.53:<464&&')586745//896,>D31?..)-((2/69<:70/653%$((;@315,&&$#$$&&)'&%'%
@a83b4216-3e32-45d6-b333-711a1d3b5a44
TGATGCGCTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATTATAAGGGCAAGGAAGAGAATAAGGAAATCAGAAAAAGACTTGCTAGATGCGGCAGACCGTTTCCGGTTTTTGGCAGCTCTCGGTAAAAGTTAACTCACTGACTGATGATCGAATTACTGAAAGTTGTAAGAGCTGAGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGAATGGCGGAGGTGCTGATCGCTATTACCAGGGTATCACCGTGCCTGTTATCAGACTTGCCAGATTGGCTTCCCGGAGAGAAAACTGGCTTATCAGCAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCGTTATAGCTATCGGCAGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTCCCGGGTAAAACATCTCTTTTTGCCCAGTGTCGTCCAGAATCGCGCGTTCAGCGCGTTTTTCAGCGGTGCGGTGTTTACGGCATTATATTAAATTTTATAATTGTCTTTAGTCATTTGCGCTATGATTTGTAGAGGTGGAGTTGTTTCGTATTTTTGATATAAATTCTTTTATCTCACTGAAGCGGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATAGCACCTATTCTAGAATCTGATTCCTTATTACAACTAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAAGCACTTAATCAGGATCTAAGGATATGTTAATAATAGATTCTTGTTCTTTATTTTATTGAATGATCGTCTATATATCAAACACCTCTGCTTACACGCGTGAGCAATGGTTGAATCTTCTATTGCGCCATTCTTGTTTTTCTGTGATAAGAAGATATTTTGTGCTTCCGTTAATGAAAAGCTGTTTCATTTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAGTATCGAATCTTTCCGTGTCAGAAAAACGATTCGTCGGCATCGATGATTAAGAATATGCTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTTAGTTTTGTCTTTCCATTTATTTTTCAACATAAGCATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTCTCGGTTTTCATTTATCTCACACTTGACCATTTTCAACTGAAAAGAAAAATCATCCATGTTAAATTACATTGCTGTGAGTTTTGAGATTCCCTTGTCTCTTTGATCTTATGTAAGATATATCTTTTCTTTTTTTATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATGTTTGTTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGATAATGATTCACATTTTCTATCTCATCAATGCAAGTAATTGGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCCTTTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCATAGTCCTATATCTAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTTTTTATCGTTGCTTCTTTATTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTGAATTCATATAGCTTACCTTTTTTAGTTTGTTTTTATTTCTCGTTTATTTCTTGTACTTTTTGTATTTATTTTATAGTAATCAATGTGAATTCTTCTGGGGGGTTCTTGCGTTCACATGTTTCTACTAACCTTAATCATTAAAACATTTCCCGCACTAACCCAGCCGAGGTTTGTCGCAATGGGGTGATTGATGTTCGATAATGACAACGTTGCTTGTCACGGCTGGACTGTGTATTATCCATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTACTTATTGTTATATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAACTATCCCCAAAGTGAGTTTTGCTATTTAAAAGAGATGCTTCATTTCTAAAGCTTTTTACTTACAACAGAGCTGCTGGGTTTTACGTCATAAATGAAAATATCGCGAAGCTCCTATTATCGATGTTTTCCCAAAGAGTTGTTTTCCGGATATTACATTGGTGTTTTTAGTTGTTGAGTTATGCTCTCGAAACACTTAAAATTTTAAGTGGATATCTTTTATCATGTTTAACTGCTCTCATTTCTATTTACGTTTATAGTAATATGTGTTTATTTATGCATCACTATACCACTGTTTTCTTTTCTGATATAATCAAAATAATATTACTTTATAGTCCTGTTTGGTTGATTTTAGCAGTTTGTCAGGTTTCTTCTTGTGATTATTGTGTTCTGAGTCATGTCCTAAACTGAAAACAGAAAAACCACCTGGGGAGGTGGTTTGATCGGGGTAGTCAGTTGGGGAACTGCTTAACCAGGTAACTGTCGAGACGAAGGTCACCAAAACTGTCCTTTCCACAGTGTAGCTGTAGTCAGGCCATCGCTTTAAGTACTCTCTTGAACCTCTCGCACATCGAAGCTTTTACCAATGGCTGCTGCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAGAGACGATAGTTACCGGATAAGACGCAGCGGTCGGGCGAACAGGGGGTTCGTGCACACAGCCCAGCTGGAGCGAACGACCTACACCGAACCGAGATACCTACAGCGTGACTGTAAGAAAGCGCCACGCTTCCCAGAGGGAGAAAGGCACGGACAGACATCCGGTAAGCGGCAGAGGTCGGAACAGGAGAGCGCATACGAGGGAGCTTCGGGGAAACACCTGGTATCTTTATAGTCCCATCCCGGTTTCGCCACCTCTGGCGAGCGTCGATTTTGTGATGCTCGTCAGGGCAGACGGAAACTCTGGCGCTGGCTATCGGTGCTTTGCTTTTGCTCCTGCTGCTATCCCCGATTCTATGGATGACCGGCAGCCGCTTTTGGTGAGCTGACACCGCTCGCCGCAGTCGAACGACCGAGCGTAGCGAGTCAGTGAGCAGGAAGCTGCTATGTGACATTTTCTCATTACGCTCTGTTGTGCCGTTCGGCATCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGCTTCTGCGAGTTCGTGCAGCTTCTCATGGCAGCCTGTTCGTCAGCATCAGGTACGTCAGTTTTCGAGCAGCGTCAGGCTCTGACTTTTATCATGTTGAGGTGGCTTGCTGCTGCTGTTCATCTTTCGTTTCTCCGTTCTGTCATCATCTCGTTGTGTGATTATATCGCACATTACCACTTTTCGACATTTTGCTGCCGTTATTTGCATTGGTAGTGTGGCGGCGTGCCGCTTGGCTTTTTGACGGGCATCGAACACTGTCACTGCCAAAAACTGCAAGTGCCTTTGTCAGTGGTCGAGCTTGCTGACAGGACGAGTGTCTGGTGTTATACCGCGCATACATGCGCAGCTATTCACAATTGCCCTGAATGAGGCGACACCCCATGTCTGGAGGCCATGTTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCGGGCTATCAGTGTTCGTCGGCGGCAGAAGAAGAAGACGGGAAATCAGAAAAGACTTTGAATGCGGCAGACCGTTTCCGGTTTTACGGGCGGCAGCTCTCTGATAAGTTAACTCACTGACTGATGATCGGGTACTGAAAAAGTTATGAGACTGGGGGCGTTACAGAAAAGCTCTTTATCGACGGCAAGCGTGTCGGGGACGGGAGTATGCGAAGGTGCTACGATCGCTATTACGGAGTATCACCTGTCTCTTATACACATCTCCGAGCCACGAGACCAGAGTGCGCGCGCAGCAATTACCCGTAACT
+
&)('%(%#%%(-5-,&8;:2-*0..2-6700(&*+&&-)/==96325.(-.'=D?:1&+&%&..%&+&'*$%'4*+,''$%$#&)+3<82@437-51%0''''$#$$%1%%((-22=A=B>GD1*7&*+($$$%'***479/6/6944&&;).DD?++%$-/,55D<@B+&3&%%&-)43448%%+=00*,($14.%#+)=A>IFA::933B?@?@A5GHIDAD@=B18C:<:.0-'&%&)-?B6.0%),.18.2++3@43=A<<@=>?7697,1,3024.&1(*))@7:9:=>=1)=369///&&&$+&&&$*45;<?=15%'%)9663.&%%###$&''$000BC6>@27=@B=CAB:<44/>=656464:A23,;-.01/424--22%#%'%.3104,%$.32%%&+:88651-A>=;>BCB?E;;A22::<9;F<;<7)0@'.<8:>A>;=@CD=88C@9()1($&7%156%%4&'&+56(&*7:C459.2-.++*EF8,2'728://%('&),&%)$$2&&(+%%80..-?AFC>;67662-5798,,9;89;M=D;;ED;62=C?,..$$'$)561667714<0**+-/00/).BAB?AADC@EDE?=9<>B668738)/$'+36>:C:=4=FA;C45DADJKPK@IF<JI9455-#(%##$%%,,../(''.51/044:0,/,<22406/,'-*%(../6;<;<<ACKITI.8=?>3<CE>=56<?AAG8;=6,-)&,$#%(121/+6<?:;<'(;@?3-&((,7<E:<CC@AHG?JE8A5%/;;?@AGC9<3.)+*+*.:9;;86273.(('((*0),275**01.,20542233;<=:3(+2/&&+7:B;76..0;CEEHEFD=J?87;I>).(%-88845,./'C><HEIH1@7<AD;?:C?//695661,-,(:;+3/8<B=12;44@@??9<CB732++1))3*)*)/+=7@@:+*%&,.('$8459112%#)0858=E;8832839948;=B<961<)3>:954767/6:<=;<G8C446:@G>BBKH2228:?@;&2A=D>:62))9;GCCFJ94.<=900)2;FF;.9?FA<=FGKC><==5?*/7=?B<BEEA,=796'(13'3130<HHEF?>,.-0<6B>?ID,.0878/.6,../%(3135=**A><78//-0/1@===66;871/422<=@;@CCOI@CF=?99018G@CCJC>BC47DCMBB@BC@+,9<<36-,11..568:9IFF=?;=88D2$+;2E>915+$#%*,-@@02672$++350*,'+%$;A@K?=7;=A1/135848:<021%%$$$'*+)(,./8BBEFB<<FAMD;@=5C=;??>A@BAAH=<GF<;69,,+-5BBB@EE?80)52:88*3.:7=>.68+,36;%%863'%)'&*/4:&*:ALEG5CHB<ABFED=?5860==GDC=783>>7*>?89983()/3-1&&$$#+-$#%&-//**%(&-6?-*>01''&''%*$&#)+-/<3939D@<::;2-232BA<86237;;788B*23)*$%$$&5:<57891/>58;><0+(**.9=C?99?9I>4<4573@AD;=%BB@99.9;BA;=?EKE<8=5:>?AA@+?A7-+'(.,?C?BH@<=<@@@BDEC3+-),3(+,/)75CD?::<5;</1?==1*91DC@??A:870>@A>=?=;-.48=BDCB3>48<./EBBGGJ:3*886046;3999>883DA0236468.%562BCFBAADAEBACEDD>?0406697(+7**3-658FHIBAC=+9'3(.,'*+*)001>MHA>4?@BJ>GEEB@==?@<,..5890<<1)./()$-8:CBB71.67.'',998:54/;4,7.&##%(**59;>@4..2221=:6/+)'+,022+/)**.1/'%$&3677;88@7..,+///(%+&')*%('$$%%*#%%)&%%612%'?>>=9AGBEBC>84/25/-$)%%'%#&)(&,&'%'*,%%.$(,$#$%&%%$%$&#%')%23*/-++-+$##%08=8>11)1@>;933414-41(22133>;686:2<71;.($$&'*/1393+)*,1==<AAE>JHG:;FFA7A45B>99<??=?A@<B=..-8654863-.+#,)(267K.''79@A=CMH/(352-++2/02;<A;<<=4.-....*&$$&&()),4)<8<965I7;CIFQGA>=>F;?;>=9..46943((%#$$%##%$(*6.2>;5<=ED;>VK449;9)'%4,:(59JE397=9/,.,%&'&)&):378LI>8=D=1-)''./7<;;9@4=955:;>79;=FE;@@IKG677C@BE(@<::98/,59%%$)+)&&$*%.32*-7<?>:,+;@=7-'?@+)(,$'&'$..-;8@?94:?:<89C41><?@0*)00*+;0.3GB9?AK1'$++67>=A;@589C@@B8B<>>;<>DB==?=>AF@?@>*/2(''1590)&))2+0@85,&,6991,-2&(*+)*'&,&&'&3'*-8*3$62+&%&*),'-/.)(''1?;).%%%&&%)+:@=>34@12'&,8:CF@B3&:(.51,*+961>;:''3%4<:@4))+005405=@=6081%%,%.84%%,+<5;20477:-%,*33979>(.$/'(A?=D>7761),0/-16:9618*$$%$'((<66552$#,1/7>?=)07-,+-**'*++%((2;<8A?3.))*8::89)9,/528=76:<I=8<3I9=6CA>AC88BG?133<29:0-2202/81ADDHDECHE@BB.*=C92/+(,2:&)95:79.*/087?613-B.).<685444)&+%%'+&&:22;@?<FA?CG?:35,*&.-)7>>::93'($%&&'..==8:56+0)*>><73,;87>?>A'#(10)#-&12%.+$"(.0*)$$(*6,,1'-.,-+5%('%+&),%=0219+$/)6(%)@;.))**,$767.63543(,**'-57'(*'&(%$%$$%%&&&%$$*&%&&66-158@B??>4771?.2(%%%7409D?A@EMJ@A?;=(#)3.75-4')*%')/&(%%$#$)%'((*)-('$(-*:-655023=2567:?9@?'/(&&'%%,4457512.=1.(#%3:;98643$$$'*-0://2>7)++3-&..6067/:325A???&;4618''2044>=<<CAA6051/*1(0&/360.)$&&%$$$%#$'%$&,:7FADFN=>->$+%2@>B:=/(*-(527506597=D-$:,799<79821&')&0.;0<;>;?;<@;CFGDG@>?GG?FH;;DAE:50<;?><4-00477/-/-%,-6-29:56:>>61F462::<;?<4;E9A94@BBF@D61/-:7?C63*$70,&=,(0+-14B/8210:@;C;9>5;=60=-@;44566%#(3/-2/1'$)%+/899158<:9%#*+95?96;<=?=<@B=;C7A9GA>223'&:<24>'(,06/.*&*'#&9>?<?+/$+(()&&&(.33@.0,)%%122/&,,,671.*$021%&$#'$$##%'$%&'&$'%$%$,65./5*35569632--&)'&%',%%)-))75<B::=534@?:4469+.((&(&,-/3;.(.%+3)*))%$/00'++9D5405;8.$$(62,,+((=676010-.+0/3)('*#$#%$%#%%+$,+$)-,/-4*45.*-$$$'%&&&&(+'+.--586/-&#&$)-9:6:;CD>/2598@@@61;323/9'(6465172692631.0-<//C<;2+-%*32;:;972&&.&'$%&.1)''%((<6831*/70)@5584+)&'&&*554>*+/',41178:=EE%078=HC?3##%&17)-&%**,(*4$*$&$%$&1//9?@@>7<1(277D@>:B&)+;55-9(-'('=>;639*51%%&-.*5:ABE@:43B@53(?ABDF>C?9=4.2<ACD8)$A51C18DD?@$)/)1;976<%%'3+-%'+))63*@8<1''.0?-/$0>0.=--,<9<@E@B@:980/GB?CC)733<65$2+*%%A@;?/AC:6@)<7/24*.%((+)&0.).+)$&
@9c48bc3b-5d8c-47bc-96aa-9d291f376169
GAATCGCGTTCAGCGCGTTTCAGCGGTGCATGCAATTACAGCATTATGTTAAATTTTATAATTGTCGCTAATTCATTACTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTTGATATAAATTCTTTTATCTCACTGAAGCAGACATCGTCAGTATCAATGGTTTTGTTCTTCATTGATGTACTGTTCTAGAATCTGATTCCTTATTACAACTAAAGGTAAACTTGAACTTTTGCTGCCAGTATTTGGGTAGCGTAATCAGGATCTAAAGGATGTAATAATAGATTCTTGTTCTTTTTATTTTGTTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATGGTTAGATCTTCTATTGCGCCATTCTTATTTTTCCTGGCATGATAAAGAAGATATTTTTGTGCTTCCGTTAATAAACTATTTCATTATGCGACTTGGTGATGAAATGTTAAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAGCTGATTCAGTGGCATCGATGATTAAGAATATACTTTCTTTTTCATTAAGACTCTATGCTTTAAATGCTCTAAGGGTTTGTTTAGTTTGTCTTTCCATTTATTTTTTCAACATAAACACATCGTATTTCGCTATTTCAGTAGATTGCAAAGTGAAATCATCATCACCTCAACGAAAATGACTTTTTATAATCATTTATTTTTCTCAGTTTCATTCATCTCACACTCCCAGCCATTTCCAACTGAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGT
+
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
@d3d20834-5194-4b4e-9964-b27d91ca019a
TGTGTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCCTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGCGTTAGGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGAATTAATGATGTTTATGTTGAAAAAAATAAATGGAAAGACAAAACTAAAACAAACCATGACATTTAAAAACGCGAGTCACAATGAAAAGAAAGTATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAAATTTCAACGATAAATAGGCTTAACATTTCATCACCAAGCTCGCATAATGGAAATAGCCATTAACGGAAGCACAAAATATCTTTCTTTATCATGCCGGAAAAAACAAGAATGGCGCAATAGAATCTAATCATTGCTCACGCGTATCAGAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATATTATTACATCCTTAGATCTGATTACGTTTACCCAAGTAGTGAAGAAAGCAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATGAGCATATCAATGAAGAACAAAACCATTGATACTGACATTATTCTTCAGTGAATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAGAAACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTAGAAACCGCGCTGAACGCGATTCACCGGCGCAGGCCGCAAAGAGATGTATTTACAGGAAAACAAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGTTTATCGTATGCATGAAAGCGAATGGTGATCGCACAGGGCTTTGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAAACATCACATACCACTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAGCGCCCCCAGTCTGCCATAACTTCTTTCAGTACCCGATCATCAGTCGGTGAGTTAACTTTCTTACCGAGAGCTGCCGCCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTCTGATTCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCTTCGTTTTTGTCATAAAACATGGCTCCGTATCTGACATAGGTGTCAGGGCAAAGCCTGACCTGGAACAGTGTAATAGCGTGCATGTATGCGCCAGGTATAACAATTTGCATCCTGTCCTGTCAACAAGCTCGGAGTACCGACAAAGGCACGGCAGTTTTTGGCGAGTAACCAGTGTTAATCTGACAAGAAGAGCTGCCGTGCGGTACGGCCGGTGAATTCAGCTTGCTGACAGAACAGGAGATGTCTGGTTGTTATACCGCGCATGCATGCGCGCTGGCCACGGTTGCCTGGTCGAGACTGCCCCGACACCGTGTTGTGACGGGTGAAATACGCGCGAGGCGACATCGTCGCC
+
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
@bf019ed1-2809-4d0b-849b-a42dd51794c6
GTTGTACTTCGTTCAGTGCCCGTGTGCCCTCTCTCTCTGGTCTCGTGGGCTCGAGGAGATAATGTGCATAAGAGACGGTTCCATAATCCGCCCCCTGACGAGCATCACCAAAAAATCGACGCTCCTAAACCAAAGTGGCAACCAGCAGGACTATAAGATACCAGGTGTTTCCCTGAAGCTCCCTCGTGCGCTCTCCTGTTTCCGACGACCCTGCCACCGCTTACCGGATACCTGTCCGCCACTCTACCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCCGGTGTAGGTCGTTCGCTCAAACTGGGCTGTATTGCACGAACCCCCGTTCAGCCCGACCATGCCTTATCCGGTAACTCGTCTTGAGATTAGCGGTAAGACGACAAACGCCTACTTTGCTTAGCCATTAGTAAAGTCAACAAGAGTTCAAGAAAGTACTTGAAGTGATGGCCTGACTATTTACACTGAAAGAAGGACAGTTTTGGTGACTCGTCACTGGGACGGTTACCTGGACAAGCAGTTCCCCCAACTGACTTAACCGACTGATCAAACTCACACCTCCCCAGGTGGTTTTCGTTTTCAGTTTAAGAGATTACGACCGGAACACAATAATCCACAGAAAAACTCGACAAACTGGTTAAAATCAATCCAAACAGGACTATAAAATGTCTTATTTTAGATTCTCCCTTCTAGAAAAACTAGTGGCATGAGTGATGCGCCAAACAAACACATTATTACTATAAGCATCGCGCAGAAATAGGAGAACAAGTTTAAACATGATAAAAGAAGATATCCACTTAAAGAATTTTTAGAGTGTTCCCTGAGAAACAATAACTCTCAAACAACTAAAAACACTTAATGTAATATCGGAAAAAACAACTTTGGAAAACATCTGATGTGGGTGCCCAAATATTTCATTTTATGTTGTATAAAGAGCCAGCTCTATTGTTAAAGAAGTAAAAAGCTTTGAAATGAAGCATCTTTTAAAATAAGAAAAGAAAAACTCATTTGGGATAGCTATTTTTATAACATGGACCCATCCAAGAAATGTCATAACTAATAAAGATGAAAGGTCAAATATACAAAATACTCAACGATGAATAACACACAAGGTAGTCAGCGTGCTTCCTCGATGTTAGTCAATATTATCAAACACACCCCTCCATTGACAAACCCTCGGCTCTCAGGAAAAGAGGGAATGTTTTAATGATTAAAGGTTAATTGAAACACAGAACGGAAAAGAACCCCACAGAAGAATTGAGTTACTATAAAAATAACACAAAAAGCACAGAAATAAACGGAGAAATAAAACAAACTAAAAATTAAGCTATATGAATTCAAAACCGCAGCGATAATAACCACATCAAAACATAAACAAAAGCAACGATAAAAAACGTATCAAAACTACTAACACAAAAAGAAAGATGAAATAATAGGCAACCTAAAAGAATGAAATAATAGAGTGGCGATATTACAATAATAGCAACAGATCAAAACAAAGAGATTTTTTAGATATAGGATAAGTGAATTAAATGAAATATCAATGCTGGTGAAGGGGTAAGCAAGGCGCTGTCTTTCATTGGCTCAATCATAGTTCAAAAAGACTCAATTATTCATTGATGAGATAGAAAAATGGAATTCATTACTCGGTAATCAAGATATGATCAACGCTTTGATGAAGCAGCAAAAACCAATAATCAAAATATTTACAACACCACAGCCATGATGTAATATGTACGATAAACGAATTAGATGAAAAAAAGAAAAAGCGTCTCTCTTACATAGACTGGGAAGAGACAAAGGAATCTAAAAAACCACCAGCAGTACAATTTAACATGGATGATTTTCTTTTCAGTTGAAAGGAAATGGCTAAGGAGGTGAGATAAATGAAACAAGAAAAATAAATGATTATAAAGGAAGTCATTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAGAAAAATAAATGGAAGGAAAGACAAAGCTAAACAAACCCTTACAGAGCGTTTTAAAAGCATGTAGAGTGCTTTTAATGAAAAGAAAGAATATTCTTAATCATCGATGCCGACGAATCGTTTTCTCTAGCACGGAAGATCGATAATTTCAACGTCAAATGAAGCAACATTTCATCTATGAAGCTCACATAGTAAATAGCCATAACGGAAGCACAAAATATCTTCTTTATCATGAAGAAGCGCGCTGAAACAAGCGCAATAGAAGATCTAATCATTTGCTCACGCAGTATCAAGAAGAGGTGTTTAGATATATGAACCGATCTATTCAATAAAAATAAAGAACAAGAATCTAATACCATCCAAGTCTGATTACGCTTACCCAAATAACTGAAAAAGCAAAAGTTCAAGGATTACATATGTTAGCAAATCAGATTCTAGAATATGGCATATCAATGAAGAACAAAACCTATGTTGATACTGGCGACGATGACTACTTCAAGTGAGATAAAGAATTTATATCAAAATACAAACAACTCCACTACAAAATCATGGCTTGCAATGACTAAAGACAATTATAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAGACGCGCTGAACGCGATTCAGCTGAACACCCACAAAAGAGATGTTTACAGGAAAACAGGAAGGATCGTCAGGATCGTTTTCCAGCCTTTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGCAGGAGCTTACGATTATTCATACCGTCTGTTTTCGACAGTTTTCTCTCGGGAAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTATTAGCGATCAGCACCTCCACGCCTCCTATTGACACGCTTGCCGTCGATAAAGAGTTTTTTCTGTAACGCCCCCAGTCTCGCCTTCTTTCAGTACCCGATCATCAGTCAGTGGGTTAACTCTCCGAGAGCTGCCGTAAAACCGAAACGGGTTATTTACATTCAGCAGCCCCCTTTTCTGATTCCTGGTCACCTTCTGCCCATCAGACTGGATGAACCAGGCGACTGATAGCCCGCCTGCGCGTATTACGCGCTCTGCCAATTTGGCATCGCAAAACGCGGCTCCGCGTATCTCGGCATGGGTGTCGGGGTAAGCCTGACCAGACAGTGTAATAGCGTGCGCCTGCGCGGTACGAATACACATCATATCTGATATGTAAGCTCAGAATCCGACAAGGCACATGTAGTTTTGGCGTGGCAGTGGTATCAGCAAATGCCGTATCAAAAAAATAACAGACAGAATAACGGCAGCAAAACAGTCGAAAGTGGTACGCGATACCAATCACACAACGCAGATGACAGACAGAACGGAAAACGAAAGATGAACAAGCAGCGGCAAGCCATTTACTCAACATGGCTGGATTCATAAAAGTCAGAGCCTGACGCTGCTCGAAAAACTGGGGCTGCTTGCCCGATGCTGTGGGCTGCCATATGCAGAAACCACGAACTCGCAGAAGAACTCCAGAACAGCATCCAGACACGCTTTGAAGTGAAAATGGCACAGAGAGATAACGCTCAGGACGAATTGGGATGCCGAACGGCTGGCAGAGCGTCGGGGAGAAAATGTCATAGGCGCCTCTTCGCTACCCTCGCTCACTGACTCTATGCACTCGGTCGTTCTGACTGCGGCGAGCGGTGTCAACTCACTCAAAAGCGGTAATACGGTTATCTGAAATCAGAGGATAAAGTCTGGAAAGAACACTATGCTGAAACAAATAAGCCTGGAGGAAGCCAGCGCCACAGGCGTTTTCCATAGCTGTCTCGCCCCCATCCAGCGCTGCCGACGACAGAGTGCGCGCGCAGCAGTACGTAAC
+
52452+;>><9B*+%####$&$%"$$%*%&'*',$-),+0548($$$(89-.'$''#*($#%%'*$$.16:+5<AA).78*-$()*--75879986;233/0-+))($545645;652/0)74%+$),&'.&&&*.&')$'*.2%2109/&&'&%&$%(&()%%%1%--0061-1(2/==:>233+6-A5AB8?=CFCHIC-0(&'.39:--*%%#$$$#%%&)4),'))&($-338***$$*$$.58&&09,17>;?:32-0-&%14=<8+$(,(6-+%04660*$'49=:;6705::*1:@A=1*..+58=-00<+;-.'0/(*;852*((+##$*.+0?AFC64B.,,+::821(($#$$##*2789/6<8-&%*-13%%%$'+-0--.(-/')-(.017()$*$)*'&'(((&%&&/--003,%$,'+(',1$&&$%%):<8($&&.%$'62''+*)*.-448(13,0/,($'$%$(498+4&5('%%+:0*&5@=A:-2752;=@;4.%%&#%%'),/54+776/3$$*,(-)63:89655((0/2/,,,66/0##&(111*'&%$$+$&/$)*<?<-$-/=;=?@@951::<0-'25;($%#&%&(*'&&($$#%$$)#*/02%3++/'&(&34+.14.3'%2')(+103-7(*691500''5330,*9;;>:><7:3&%%*,'-2121.%%$)7/0&1%%%'),-953.+''%+808=;,,&)::7<6-)(()+0,7905+?;?C8@B>?>1,$)(,)+&&$$)(())4)$0,,--,2-.3.4714.)('00156+'(((-942&&.(%'*,-&$%$$%%%$)$&&+,57&.*##%&$&$&&(%/0;;705$'%.,/+-466611$"$&24/+)*+/*)0+/.6IB;9701&&(+$')*.(..-0$&&-%,%'%0%$&&#$%&%/-,%&2450%'(()&&$'-1)$$,*.--863*+,-$5.+,'%$$+,-.,++(---,)&+(((*-),,*'&*('-042(,+&31&%'697758.16475*/2;,6)5:<BAB@56;63/)&&(.$)*6'','($,+)((%&$&''&(()+()%*0211>%2/(5*,''&%''')+++*)->95/428$$,$#$$++9955%/*#&-,'%'&'$#%'-12=8;6474+,(/%%###&/576743&(45:9*1'.%%'&-7>>>==*2:+2=7=50(;74;=,,&$%%4988=?SI89@<95?78/*=A@(*(,1+822(*02.8<;=BD>&//AFF54&&&%/1+--,/+)$02(25+4GOJE>944377HNA<10--)3'--+,).+=7<C<9ED;:;<6:9:7339:1'$#&'(+6796'0-,/<:7452+$%%+*+-<;<'*(&&%($(&$$&'.8/-/576678&-$4155/05>A@?@<A@F@<?>AC7?C=A<;;:>=JM>.$,C@='G8D4A=6%'-&+3;..B</45<%+:6.+(*&'%'+,)($7$&'37.(('$*.0=>@8301..<?@>;=AD=>3BA*);@?BEMGC=34C>:,'45-(%'%554==:673*-+::81-,$&$$#'&+-+)1()')-&()/%&)&.''2//0012,''*$(+.0$%$$#($&'.7AA6*%&,-37-0,011356673255313*$$499967.056;30'/1*+:;'.9?B:767,CC<?=>:B//10*+33**-')1)+%%&*+*-,%*4.$:4+8+--*$$)47021)/*-+$)*&''%&+)4331.+++,/*5196/0**)+&*/)*=46*<;4.&%$))(%%#%$$%'((2/0()''&(/--#&5*8%%4.3.0'.'&/05'?C<<>92+$$&)%''$$#,/1074''&%,*&52=A?BMG:@@J50,6.4//+)%%()'%%&++$%)'**/:64:<1+/6+1)2//%''30;2<:>CA;66B?79),%$%,+6=?9=BC:1@31(8574''9:9?>7,/F4?=<<9+.296.9<?;>4/*+++$-('''*--00?>@6:=94C@EE3++(#$((($+..&**)$&$+&('+&&%-2->965&$-()+&&*-'-,''+%%'*+').7953.0(%&+'#%'$*$,%#$'''(('&$%:3&&1)'$%%.-<:464;@>>77277=1>>::+&&.649;;A2-$'$%$,-.152-3330344/13626+*)#%$%%%(&'''-212.44A;..9(&&&1)&87.#$(-2#/25F:B799')(('),+++,+&0131,./26-'4;=.+9''%$%''%%#$%##$%%&$%%&$+)9792()3,+416+07=>=?@D.3<<0++*$$33$$%)/12)(**:2<>453?6+7.8**2),,,77:68:=:?:9;<2<79:079@:(*?:1)*-%&.)()*&&'')&*5100/4242**.)(554573))%%%&*)(&%-11,')*)-$%&1$4($$''&$$-+#$%$%'46.2-.3.,*,*4.&+)/87>=<@345//3+-2>>>@?7,%$'&0/&$$$%'$%%%$%33<94.+$$-/&')&6*);?AAC;&(028@6575:<=73)%'%(06007855$$$%144<D>=7;.1&&&%46758:;7BC20A7564742('+37/788589<;;<>:6'('*-..7338;;59823767,+;>?A=:2+,901)($%$%&%%'$#$$#&&'/%&''%()48-$1106)2B<-'<B99/.'*++3631??;?=A;D7.12-$)$*4-.0*7&0<:2/0$$()''&'019<13<?2*:)(-.)$#%,3,.581%&*&$'$)'-())46;5@45==B912:-//CBF<;:5-<'.;?>H?4><7>>035'-7968=89;>7$'&#(5:<8948:1,,*15%.'%)%'%''*)'/)%(&%%+&+$%#&',','%%$&()%+$%))-356>A>BB>?%&&;FLXLB=8+),44>789>:.,/*1%-)()(.(*4++*'($*--2388+-0%&.-$'1*+<<@-,&&+*%%#%&#,+&$$$)(+-/*4,-&&%.$(,#$#%&$/9568,*(&%'3577335<28&314:)+&%()&##%$,($%+/-(-9$%#$%$&%.)(,$+%)*&0/,,,,-8(68@<<;>>6B<81+&*&((&$$)&%%%&$%&(''%$&*,%&+,,*/&&#$$'%'%%%&.,3$.'+'$''+*9/++$&'%$%'$''$%($%$'(*$'8,,**+*/609/&%$$%$%%&&++''&&+%%.)0*&-#$%(('$#&%$$##%)0/+%#&$'(*175)((+1,)##%#$6%(84,)((.&''$'.%$)))+##&#%&%%''$%%%&(((''&%&(&*(()*3.6<642/+.+2).<=@?>3475''''&9;1))<3857-'$%+-,0''&''(,(85=?;;4<./1+'/+5637,/C<:4555%A@:8?>687)&3.+2:01//+$&*3-55;0/,*%%*$$&.3=61.-BEC053;73./86595<9;:*%,8,-:11+-+&(//)&'$$$'%1-+0,((3+(&(&))$&+%$#$%%%%'*.,%$$%%0231)&%)*1&'9>A$850003916>%%B9;?'+8312227357=%%6A56+/000052+(',.--0/984,;>6+$$$%(*/9@C90631,%'+&%$$*.(,&&$#$$'814*+6050'2.-)&'+*$$$)1,'*,,4/14,281?75+()+/;09%$#$*&038(.9@;E*=%,&+)(*-135599',0007%&023--26:=6,,5&-/+////-2>;2%/'%&/;22%($,5=;-77565)14563%&.&%&%$$$#%&%'&-%%&#(&*$($$)@<>/6+C@;7B?>:42/4;?>?><824&%-*,.133++'&&''')&%11+0--/-&,3-.4.5'('+2.,/06;5-2)'&%*&-'(&''
@857875ee-ad29-4a18-9d09-f26f44787d76
ATAGAAGATCTAATCATTGCTCACGCGATATCAGAAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAGAACAAGAATCTATTATTACATCCTTAGATCCTCAGTTACGCTTACCCAAATAATGAAAAGAAAGCAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAATACATTGATACTGACGATGACTCTTCAATGAGATAAAGAATTTATATCAAAAATATGAAACAACTCCACTGCAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCTGAACGCGATT
+
>8,,8.9;4,8AB>88;B@BE<:2.)%%-+)*-':=+,09:=DAB;53A>@;0$D;CB<0)</9A=)8:;69<<7GR8%>D;))('48;4-@A2=<=<;,,5,3CBC**-%&&'1:B>;:B911>@AD@0/-%));6.&3116;ED?7:<B5658=62%+%42;9>:;=<3''$-%,/:13;>ABBCDCG;21>A>:F<@FFCIEF0*;887)&(0//6A@GHEE==>=?=@788&%*&%'&(+7A>GH;'65@C@9B;7=DE>H@8920/93<,,-906'&(#%25;>9716:7@8>@C=?C<9@C:97D:<:AB@EJ?EADFGGFGG>>:6..-.0106>9/@>CD:D:932.2./(10.+**)'('(&
@00b83b07-1c80-4295-bdc2-84a5c0904ca1
AATATCAATGCTTGGTGAAGAATTAAGCAGAAAACCAGCATCTTTCGATAGCCTGTCTTTGGATTCAAAGCTCAATAATTCTCATTGATGGGCGAAAAATGGAAATTCGTACTCGGTAATCAAGATATGATCAACTTTTGATAAGAAACATCAAACCAATAATAATCAAGTATTTACAGCAACACTACAATGATATGGCGATAAACAGACAGAAAAAGAAAGATACTATCTTACATAAGATGGGAAAAATGAGGGCTCTCAAATACGGCTGTATTTAACTTTATGGATGATTTCTTTTTCAGTTAAATAATATGAAGATGAATATAATAGCGAAAAATAAATGATTATAAAGAAAGTCGTTTTCAAGTTGAGAGGGTGATGATATTTTCACTTTCATTGCAATCGCGAAGTGTTTGTGTTGAGAAAGATAGTGGTTTAAGGCAAGGCACCCAGGCCCTTAGGCAAGCATGGAACGAAGAGAGAGTATTCTTAATCATCGATATAATCGACACTGGAAGATCGATAGTTTCCGGCATTAGAGAAATCGACAGCATTCGTCGCAAATGTGATAATAATAACGGAAGCTCAAAAATATCTTTCTTTTAATAAATGCCGGAAAACAGATGTCAATCAGATCTAATCGTGCTCGCGATATGAAAGGGTGTTTAGATGCTATGAACTTGATCTGTTCGATAAGATAGAGAACAGATATTATTACGTCAGCAGATCCCTGATTGCGCGCGAAGCAATGAAGAGAAGCGCAAGGGTTCAGTTTGTAGTATAAATGAGGGCGAATCAGATAGACATATCAATGAAGAACGCAAAAACCATAGTGCGACGATGATATCGATGGTCAAAAAATTTATATCAAAAATATGAAATATCACACCTACAAAATCATGCAATGACTAAAGACAATTATAAAATTTAACATAATGTAATGTACGCACCCATGAAAGCTGCGCTGAACACGAT
+
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
@dff1e9cf-3181-48a3-9165-716840aba5b2
CTATTATTACATCATAGATCCTGATTACGCTTGCAAATGAGAAAGCTCAAGTTCAAGTTTACCTTAGTTGTAATAAGAATCAGATTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGATGACTGCTCAGTGAGATAAAAGAATTTATATCAAAGAAAATATGAAACAACTCCACCTACAAAAATCATAGCGCAATGACTAAAGACAGTATAAAATTTAACATATGCTGTATTTTGCACCGCTGAACGCGTTCTGACGCGA
+
24701'..'%&%7%10/.)),;A==843&%).$2-/0(&&#%%'#"#+&&%(,2&'3+36,00053;:80''##$%-&0041.21.<(6<653<@@CD=><=B@AE+<B@ABC6<?CD@C@@=748359.23*')('(/6,56302/%*.-/35<496:78*$%%%$&&)&05%;66?A,6(($(84?>>=3.=.5>=@9<;?:3339EH9;;-,)=<@AC-:8<>877'$+289850+..++*)+/2:<2425&$(''.//<6=8+%$
@e7414c31-3d07-44df-b1d1-ec570df4fd01
CATTGTACTTCGTTCAGTTACGTATTGCACGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTCTCAAGAGACGGCTACTAACACAAAAAGAAAGATGAAATATGGAAAAAAAACCTAAAGAATGAATAATAGAATTGATATCGCAATAGCAACAGATCAAAACAAAGAGATTTTTTTAGATAGGACTAAGTGAATTAAATGAAATATAAATGCTTGGTGAAGGAGTAAGAAAGCAGTATATCTCCATTAAGCTCAATCTGGTTCAAAAGACTCAATTATTCTCATTGTGATAAGATCAACAATTCAAACTACTCAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAACAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAGAAAAGATATATCTTATAGACTAGGAAGAGACAAAGGAATCTCAAAACCTACAGCTTATTTAATTTAACATGGATGATTTTTCTTTTCAGTTGAAAATAGCTGGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGTCATTTTTCGTTGAGGGTAAGTAAATAGTTGCTCTTCCTTTGCAATCTACTTGAAATAGAGAAGGAATTAATGATGATGTTTATGTTAAATAAATGAGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTCCAACCTGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAACTCGCATAATGAAATAATACCATTAACAGGCTTACAAAAAATATCTTTCTTTATCATGCAGGAAAAAACAAGAATGGCGCAATAGAAGATCTAATCATTGCTCACGCGCTGATATCAGAAAGAGGTGTTTAGATATATATAGACGACCTATTCAATAAAATAAAAGAACAAGAGAATCTATTATTACATCCTTAGATCACAGTTACTAACACCCAAATAATGAAAAAGAAGCAAAAATTCAAGTTTACCTGTAGTTGTAATAAGGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATGACTGCTTCAGTGAGATAAAAATTTATCAAAATGAAACAACTCCACTCAATCACAGCTCATGACTAAAAACCAAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTAAACGCGCGCGATTCTGGCGCGAGCCACCGCAAAAGATCTTTACGAAGCAAGAGGATCGTCGGATCGTTTTCTGGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTATTCATACCGTCTGTTTTCGACGGTTTTCTCTCCGGGAAGTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGGTGATACTCCATGTCATGATCCAGCACCTCCACCTTACTCCCTCCCCACAACCACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCAGTCATGCTTCTTTCAGTACCCGATCCATCAGTCAGTGAGTTAACTTTCTTACCGAGAGCTGCCCGCCCGTAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTCTGATTTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCATAAAACATGGCTCCGTCATCAACCTGGATGTGGGAGCAAACCTGACAGGGCAGTAGCAATAGCGTGCATGTATGCGCTGACCTCTCGGTGTGCACATCTATTTTGTCAGCAAGCTCGAATTACCGACAAAGCCCAGCAAGTTTTTGGCAGTGACAGTGTTGTCCTGACAGAAAATGCCCGTCAAAAAGCCCAACGCTTGACCTAGCAGCAACAAAACAGGTAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACGGAACGGAAAACGAAAAAGATGAACAAGCAGCGGCAAGCCGTACTCAACATGGCAGGATTCATAAAAGTCAGAGCCTGACACCAGCAAGCTAAGTTTTCCAATCTCTTTGACGAAACAGGCTGCCATGTGTGGCTTTTTGAACTCGCAGAAGAACTCCAGAACAGCATCCAGACACGCTTTGGAAGTAGAAAATGGCACAGAGAGATAACTCAGGACAGGATGCCGAACGGCACAACAGAGCGTAAGGAAAATGTCACATAAGGCGCTCTTCCGCTTCCTCACTGCTGACTCACTTCCACACTCGGTCGTTCGACTGCGGCGAGCAGTGTCAAAACTCGCAAAAGCGGTAATACGGTTATCTCCCACACAGAATCAGAGATAAATCAAGAAAACCATGAGCAAAAGCAAAGCACCAGCGGGGAAAGCCAGCGCCACCGGCGTTTTTCCGGCTCCGCCCCTGACGAAGCATCACAAAATCGACGCTCGAAATAAGGAGGTGGCGAAAACCCGAACAGGACTATGGTCTGGGTGTTTTACAGGCTCTCGTGCGCTCTCCTGTTCGACCCTGCTGCTTACCTGGATACCTGTCCGCCTTTCTCCCTTCCGGGAAGCGTGGCGCTTTCTCATAGCGCTGTGGTATCTCGGTTCGGTGTAGGTCGCTCAAGCTGGGCTGGCGTGAACCAGTCAGCCCACGACCGCTGCGCCTTATCCGGTAACTATCATCTTGAGGTCAACCCGGTAAGACGCGACAAAGCGCCACTGGCGGCAGCCATTGGTAAAGTCAAATCATGCGAGAGGTTCAGAAGTACTTATGAAGGCGTGGCTGGCTTCTGGCTACACTGAAAGGACAGTTTTGGTGACTCGTCGCACAAGACAGTTATTACCTGGTTAAGCTTTCTGCCAGTTTGACTTAACCTTCGATCAAACCACACTCCCCGGGTGGTTTTCGTTTCGGTTTGGGAGATTACACACGACCAGAACACAATAATCCCTAAGAAGAAACTCGACAAACTGGTTAAAATCAATCAAACAGGACCTCATCATCATATTTTGATTATACTTCTAGAAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAAGGCTAAACATGATAAAAGATATCCACTTAAAAATTTTAAGTGTTCAAAACACTACTTTCTAAACAACTAAAAACACTTAACGTAATATCCGAAACTCTTTACGGCGCATCGATGTGGAGCGCGATATTTTCATTTTATGACGTAAAAAACCCAGCAGCTCTGTTAAAGTAAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTGGGATAGCTAACGCATAACATGGACACATCCAAAGAAATGTCCATAACAATAAGAGATGAAGGTCAAGTAACACAAAAATACTCAACGATAGATAACGCACAAAGTGAATCAAACGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAAGAGTCTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAAAAAGAACCCCCAAGAATTGATTACTATAAAAATAACACAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAGGTAAGCTATATGTGATTCAAAACCGCAGCGATAATAACCACATCAAAACATAACAAAAAACAACGATAAAAAACGTATCAAACTACTAACCTACAAAAGAAAAGATGAAATAATAGGCAACCTAAAAAGAATGATAATAGAATTAACGATATTGCAATAATAGCAACAGATCAAAACAAGAGATTTTTAGATATGGACTAAATTGAATTAAATGGAAATGTATCATTAACGGTGGAAGGGAATAACTGGAGGCGCATGTCTTTCATTAGCTCTCTGATCACCAGTTCAAAACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCGACTACTCAGTAATCAAGATATGATCCTTACTGATAAAAACAACATAAAATAATAATAATCATCTTACAACAACACACAATAGAAGCGATGTGTATATGTGCAAATAAACGAATGATGGAAAAAAAAAGAAAAAGATATATCTCACATGTAAGACTGGGAAGAGACAAAGGAATCTCAAAAACCTGGCAATGCAATTAACATGGATGATTTTTCTTTCAGTTAGAAAAATAAGCTAGGAGAATTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAAGTCATTTTCGTTGAGGGTGATGATGAATTACCTCCCTTACAATCTACTTGAAATAGAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCACCGTGCTAACTATATGAAAAGAAACATATTCTAATCATCGATGCCGACAGATCGTTTTCTGACACGGAAAGATCGATGGTACAACATTAAAATGAGCTTAACATTTCTCCTGCTCGCATAATGAAATAGCCATTAACAGGAAGCACAAAAATATCAACAACTTTTTGCTATTGAGAAAAAACAAGAATGGCGCAATAGAAAATCTAATATATTGCTCACATTCTGAAAAAAGAGTGTTTAGATATATAGACGATCTATTAATAAATAAAAACAAGAATCTATTATTACGTATAGATCTATTAACACAAATAATGAAAAGAAAGCAAAAGTTCTAGACACCTTGATTATAATAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACGGCAGGCTGACTGCTTCAGTGAGATAAAAGAATTTATCAAGAAATACTGAAAGCTCTCCACCTACAAAATATCATAACAACTGACTAAATAATTATAAAATTTAACATAATGCTATGATGCACACCACTAAACTATCTCTACTTACACATCTATTACCGGCGATGAGAGAGTGTGGCAATACGTAAC
+
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@d661f019-78e1-4c96-9aec-c8d4b7df233a
GTTTTCGCCCGTTCTGATTACGTATTATTGCTGCGCACTCTCTCATAGTCGTGGGCTCGGAGATGTGTACTAGGGCTCAGATGACTTATTATTACTATGTAAACATCAAACGAAATGAAACCAGTTAAACTTTGATAAAAGATATCCACTTAAAGATTTTTAGTGTTTTGAGAGCATAACTCTCAAACAACTAAAACACCCAATGCTAATATCGGAAAAAACAACTTTGGGAAGAGCATCTGATATTAAGACCTGATATTTTCATTATGACGTAAAGGCAGCTGGCTCTGTTAAAAGTAAAAGGCTTTGATGACATCTCTTTTATCTGCTGTTGGGATGATAGCTATTTTTATAACTGGACACATCGAGAAATGTCATAACAATAAGAGATATGAAAGGTCAGAGAAGTAACACAAAAATACTCATTTGATAGATAACACACAAAGTAGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCCCTCATTTGACAAACCCTCAGCTCTCAGGGGAAAAGAGGAATGTTGCATGATTGAGTTAGTGAAAACACAGGAACTGGAAAAGAACCCCAGAAGAGATTGATTACCTATACAAAAATAATATACCAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAGCTATAGATTCAAACTGGCAATAATAACCACGTAAAGAGCACAAACAAAGCAGCGATAAAAAACGTATCAAAACTACTAACACAAAGAAAAGATGAAATAATAGGCAACCTAAAAGAATAAATATAGAATTAACGATGTACAATAATAGCAACAGATCAAAACAAAGATTTTTAGATATAGGACTAGAGTGAATTAAATGAAATATCTGATACTTGGTGAAGGAGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTAAGTTCAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTGCTCAGTAATCGGGACTATGATCAACGCTTTGATAGAAGCAGCAAAGCCAATAATAATCAAACCTTTTACAGCAACACAGCCATGATGTAATATGTACGATAAATGAGCTTGAATTAGATGAAAAAAGAAAAGATATATCTTACATATAAGACTAGGAAGAACAAAGGAATCTCAAAAACCTACAGCAATACAATTTAACATGGATGATTTTCATCCGGACAAGAAATGGCTGGGGTGAATAATGAAACCGAAAAATAAATGATTATAAAAAAGGTCATTTTCGTTGGGGAGTGATGATATTGATTTTCCACTTCCTTTTGCAATCTACTTTCTTCAGAAACTCTGTGAAGAAATTCAATGATGTTCCCATGTTGAAAAAATAAATGGAAAGATAAGAAACTAAAACAAACCCTTCTGAAACCCATTTAAAGCATAGAGTCTTTTTAATGAAAAGAAAGTATATTCTTAATCATCAGTGCCAATAGATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAAGCTTAACATTTCATCACAAGCTCGCGTAATGAAATAGCCATTAACAGGCTTACAAAATATCTTTCTTATCGCTTACCAGGAAAAAAACAAGAATGGCGCAATGGAAATCCCAATCATTTGCTCACGCGTATCTAAAGAAGAGGTGTTTAGATATATAGACGATCTATTCATTAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCTGATTACAACACCCAAATATTAATAATGAAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAAGCAGGAATCAGATTCTAGAATAGGCATATCAATGAAAGAACAGAAACCATTGATGCAGTGGCTACTTGAGTGAGATAAAGAATTTATATCAAAGAAATATGGAAACAACTCCACCTACAAAATCCTTAAAAATTTTTAGCCATTCTGAACAATTAAGGTTAACAATGCTAGCAATTTGCTTTTTAACTCATAAAAGAGTGCGCTGAACACTGATTCCCAGGCGCAAGACACCGCAAAGAGATGTTTGCGGGAAAACAGGAAGGATCACGTCAGGATCGTTCTAGCTCGCTGCATGTAAGCAAGTGGAAATCACTGCAGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGAAGCTAATCTGCCATAAATGGATAACAGGGCACGGTACTCCGTAGTGCTTGATCAGCACCTCCGCATACTCCCTACTCTACCCGACACGCGCAGGTCGATAAAGTTTTCTGTAACGCCCCCAGTCTCAACTTCTTTCATTTTCCGATCGTGATCAATTGAAAGTTCATGCTTTGCCCACCAGGCTGCCTTCATAAAAGCTGAGCAGTCTTGCCGCATTCAACAGCCCTTTTTCTGATTCCTGGTCTTCTTCTGCGCCGTCAGACGAACTGAAAGGCGGCAGCTGATAATACCTTACGCGTATTACGCCCACTTCGTTTTGTCATAAAACACTTGGCTCCCGTATCAGCATGGGTGTCAGGAGCCACCAGAAAGCCCACGACCAGACACGAATTGCTAATAGCGTGCATATGCGCGGTATAACAATTACACATCCTATCCTGTCAATAAGCTCAATTTTAAACGAGGCACGGCAGTTTTTGGCAGTGACGGTGTTGTCTGACGAAATGCACCCGTCAAAAGCCAAGCGGCAGAATAACGGCAGCAAAACGGTCGAAAAGTGGTACGCGATGCCACCTATAATCACACAGCAACGCAGATGACAGACAGAACGGAGAAAACTGAAAAGATGAACAAGCAGCGGCGAAGCCCGTACCTCAACATGGCGGGATTCATAAAAGTCAAACCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGAAACTGCACTGAACTCGCAGAACTCCAGAACAGCATCCAGACACACACTTGAAGTGAAAATAAGCACAGAGGAGATATAAGCATAGCGGGACAGGTGCCGAGCCTTTGTGAGCGCAAGGGAGAAATATCACATAACGGCTGCTCTCCTACGCTTCTACTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCGAAAGCTCACTCAAAAGCGGTATTACGGTTATCCACAGAATCAGGGGATACAAGTCGGAAAGAACATGTGAGCAAAAGCAAAGCACCGGAGGAAACCAGCGCGAACGTTTTCCATAGGCTCCGCCCCCTGGCCGAGCATCACAAAATCGACGCTCTGACCAGGGTGCGAAACCCGACAAGGACTATAAAGATACCGGGTCGCTTCCCCTGGAGGCTCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACGGATACCTGTCCGCCTTTCTCCTTCAGGAAGCGTGGCTTTCTCGCTGAAAAACTCACCGCATGCCGAAATTATCAGTTCGGTGTAGGTCGTTCACTCCAAACGTTTGTGCGAACCTACCCCATTCGAAGCGCCGACCGCTGCACCATATCAGTAACTATCGTCTTGAGTCCAACCCGGTAGACACGACAAAAGCACCACTGGCGGCAATACATTGGTAAAAGTCATTGAGAGGTTCAAGAGAGTACTGAAGTGATGGCCACAGCTACAGGCTTTACTGAAAGGACAGTTTGTGAGTGACTCGTCTCGCACAAGACAGTTACCTGAATTAAGCAGTTCCCCAACTGAAGCAACCTTCAGTGAAGCCACTCTCTACAGGTGGTTTTCGTTCAGTTTAAGGGAATTACGACCAGAACACAATAATCACAGAAGAAACTCCGACAAACTGGACAGAAGTAATCAAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAGAAACAGTTAGCATAGTGATACATAAAATAAACACCTGTCTCTGCCTCTCAGGACCACAGGACAGAGTGCGCACTGTGGCTGTAGCAAC
+
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
@9d767c57-760e-4d76-8c22-5462a7ee667a
CAAAAGTTCAAGTTTACCTTAGTTGTAATAAGTCGAATTCTAGAGATAGGCATATCAATGAAGAACAAAACCATTGACTTTGACGATGACTCCGGTGGATAAAGATTTATATCAAA
+
+88*'0'(,(,-020)'*',,2,.&'(,&%&%.-'%&,.1***&&,*+'%"%&)--*+33)7832414.'%%#$*46/////)4223.,))(/%)/(,;899221;<98<634$(*
@7bb5dffb-edba-49c4-924a-ba69e6a9fcbd
CGTACTTCGTTCAGTTGTATTGCGCGCACTCTCTGCAGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGCTTTTATCTCACTGGAAGAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTACATTACACAACTAAGGTAAACTTGAACTTTTGCTTTTTTAACTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAGGATATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACCTCTTTCTTACACGCGTATGAGCAATAAGTTAGATCTTCTATTGCGCCATTCTTGTTTTCCTGGCATGATAAAGAAAGGTATTTTTGTGCTTCCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTTAAGCTCATTTAATATTTGAAATTATCGATCTTTCCGTGTCAGGAAAACGATTCGTCGGCATCGATGATTAAGAATATGCTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCCTGAAGGTTTTGTTTAGTTTTTGTCTTTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCTCAACGAAAATGACTTTTTTATAATCATTTTTCTCGGTTTCGTTGTCTCACCTCCCAGCCATTTTCAACTGAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTGAGATTCCTTGTCTCTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTCATCTAGTCGTTATCGCACATATTACATCATGGCTGTGTGTTATTTATAGCTATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCATTTATATCTCATCAATGAGAATAATTGGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCCCCCTCCTTCACCAAGCATTGATATTTCATTTGTTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGCTGGTTATTATCGCTGCAGTTTTGAATTCATATAGCTTACCTTTTGCCAATTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCACCAAGAGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCCTGAAACCGAGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGAGGGACACGCTTGATTCACTTTGTGAGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTTATTGTTATGGACATTTCTTTGGATGTCCATGTTATAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAAGAGATGCTTCATTTTCACAAAGCTTTTACTTTTAACAGAGCTGCTGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCAATGTTTTCCCAAAGTTGTTTTCGGATATTACATTAAGTGTTTAGTTGTTTGGGAGTTATGCTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTATCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTGTTATGCATCACTATGCCACTGTTTCTTTTACAAGTATAAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTCTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCTAAACTGAAAACGAAAAAACCACCTGGGGAGAATTGGTTTGTTTGATCGAAGAGTTAAAGTCAGTTGGGGAAGAAACTGCTTAACCAGGTAACTGTCTTATTTTGAGACGAGAGGTCACCAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTCTTGAACCTCTCGCACGTATCGCTTTTGCAATGGCTGCTGCCAGTGGCACTGTCGTGCGCACCGGGTTGGACTCAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGTTCGTGCACAGCCCAGCTTGGAGCAGGCGACCTACGCCGAACCGAGATACCTGCAGCGTAGGCTATGAAAGCGCCACATTCCCGAAGAGAGAAGGCGGACAGGTATCCGGTAACTATCGTCAGGTCAACCCGGTAAGGCGATAAAGCGCCACTGGCAGCAGCCATTGGTAAGAATCTGTGCGAGAGGTTCAAAGAGAGTACTTGAAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGACTCGTCTCGCACAAGACGGTACCTGGTTAGCAGTTCCCCAACTGATAACGGCTTCGATCCGGGCGGTTCAGTTTTCATTGCCCGACAAGTACAATAATACGAAAATAATCAGGCGAGACTATAA
+
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
@c73a0fe7-1e97-41ff-8f44-7ba2c8da08de
ACGTATCCAGAACTACTAACACAAAGAAAAGATGGAAAGAATAATAGGCAACCTAAAAGAATAGATAATAGAATTAACGATATTATTTGCAATAATAGCAACAGATCAAAACAAGAGATTTTTTAGATATAAATTTAAAGTGAATTAAATAAATATCAACGAGTAGCGAATTTGAAGGAGTATGAGCCTTTGTCTTTCTAGCTCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAGAAATGGAATTCATTACTCAGTAATCAAAGATATGATCAACGCTTTGATGAAGCAGCAAAAACTAATAATAATCATATATTTACAACAACACAGCCATGATGTAATGGCAGTAGATAAACGAATTAGATGAAAAAAAAAGAAAGAAGATATATCTTACATAAGACTGGGAAGAGACAAAGGAATCTCAAAAACCTACGGCAATGCAATTTAACATGGATGATTTTTCTTTTCAGTTGAAGAGAAATGGCAAAAACAGGAGGTGAGATAAATGAAACAAGAAAAATAAATGATTATAAAAAAGTCATTTTCGTTGAATTGATGATGATTTTCTTCCTTTGCAATCTACTTGAAATAAGTGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGTACATTTAAGCATAAGAGTCTTTTAATGAAAAAGAAAGTATAAGAAATTCTTAATCATCGATGCCGACGATCGTTTTCTGACACGGAAAGATCGATCATCGTGAGCTTAGCGTTTGTGCCAAAGCTCAACATAATGAAATAGCCATTAGAAGCACAAAAATATCTTTCTTTATCATGCTGGGAAAAAACAAGAATGGCGCAATAGAAAGATAATCGGCTCACGCGCGTGTAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATGAACAAGAATCTATTATTACATCCTTGATCTGATTACGCTTGCAAATAATATTAATGAAAAGTTCAAGAGTTTACCTTGGTTGTAATGGGAATC
+
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
@cf18cbbd-3d35-48bb-b6ed-bd06ba2e1568
CGGTGTACTTCGTTCAGTTACGTATTGCTGCGCACTTTGCGCACTGCACTCTCTGTATAAATATTCAGCGTCAGATGTCACAGAGACAGGATCTAAGGATGTAATAATGAATTCTTGTTCTTTTATTTTGATGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACGCGTGAGCAATGATTAGATCTTCTATTGCGCCATTCTTGTTTTCCTAACGCATGATAAGAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTGCTGAGCTTGGTGATGAAGGTAATTACTCATTTAATGTTAAAATTATCGATCTTTCCGTCAGAAAACGATTCACGTCAACATCGATGATTAAAGACTTATCTTTCTTTTCATTAAAAGACTCTATGCTTTTAAATACTCTAAGGGTTTGTTTTAGTTTTGTCTTTCCATTTATTTTTCCAACATAAACATCATTAATTTATTCTATTTCAAGTAGATTTTAAAGGAAGTGAAAATCATCATCACCCTCAACGAAATGACTTTTTTTATAATCATTTATTTTTTCTCGGTTTCATTTATCTCACCTCCCAATACATTTCAGCATGAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTGTAGGTTTTTGAGATTCCTTGTCCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTCATCTAATTCGTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATGTTGATTGTGTGGTTTTGCTGCTTCTATCAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCATCAATGAGAATAATTGAGTCTTTTGAACTAAGATTGAGCAATGAAGACAGCGCTCTGCTTACTCCTTCACCAAACATTGATATTTCATTTAATTCACTTAGTCTATATCTAAAAAATCTCTTTGTTTTGATCTGTTGCTATTGTGCAATATCGTTAATTCTAATATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTGTGTTAGTAGTTTTGATACGTTTTTATCTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTATTTCTCGTTTATTTCTTGTGCTCTTTGTGTTATTTTTATAGTAATCTATTCTTCTGGGTTCTTTTTCCGTTCTGTGTTTCACAACGCCAATCATTAAAAGCATTCCCGCCTGAGAGCCGAGGGTTTGTCACCAATGGAGGGTGGTGATCAATATTGACTCAACATTGGGGACACGCTTGATTCACTTGTGTTATCTATCGTTGAGGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTCCATGTTATAAAAATAGCTATCCAAAATGAGTTTTCTTTTTATTAAAAGTGTACTTCATTTCTAAAGCTTTTACTTTCAACAGAGCTGCTGGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTTACCAGGATATTACATTTAGTGTTTAGTTGTTTGAGTTATGCTCTCGAAACATAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATCTATGCATCACTATGCCACTGTTTCTTTCTAGAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCAGGTTTCTTCTTGTGATTATTGTGTTCACCAGAAAGGTCGTAATCTCCCTAAACTGAAAACGAAAAAAACCACACCTGGGGAGGGTGGTTTGATCCAGAAGGTTTAGTCAGTTGGGGAACTTGCTTCGACTGGGTAACTGTCTTCTTGTCCTTTCAGTGTAGCTGTAGTCCATCTCTTATACACATCTCCGACAAACTGGTTAAAATCAATCCAAACAGGACTTTATAAAGCGCAGTGCACTATTGATACGCCGTAACACATTATTACTATGTAAATAATTAAAATACAAAGTCTTCGAAGCATCTTCTTCCATGT
+
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
@4e07cefc-ddfe-479e-a9a2-4416fdf6b623
CGTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAACCCAGCGTCTATATATCCGCTTACCTCTTTCTTACACGCGTGAGCAATGGTTAGATCTTCTATTGCGCCATTTCTTGTTTTTCTGGCATGATAGAAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCAGGCTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATATTTCCGTGTCAAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTGCGTTAAAGACTCTATGCTTAAAATGCTCTATAAGGGTTTGTTTAGTTTTGTCTTTCATTTATTTTTTTCAACACTTAAACATCATTAATTCCTTCTATTTCCACGATAGATTGCAAAGGAAGTGAAAATCATCGCTCATCACCCTCCCAAGCCACACGGTGAAGACTTTTTATAATCAGTGTTTATTTTCTCGGTTTCATTTATCTCTCCAATGCATTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTCACATTTGCACTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTGTATGTAAGACCACTTATCTTTAGCATACCGCTGCTTTTCATCTAATTCGTTTATGTAGCACGCATATTTACAGTGTGGCTGTGTGTTGTAGCATTTGTAAATATTTGATTATTATTGGTTTTGCTGCCTATCAAGCGTTGATCCATATCTTTGATTACTGAGTAATGGTGACGTTGCTTTCACCACCATGTATCTCATAATGTCAATGGGAATATGGTGAGGTCTTTTGTGGACTGCCGCCCCGTAAGAATTGGCGGTGTTGTAGAGAGGGACAGAGAGAGAAAGAGCGCTCTGCTTGCCGCCGCTATAGCGATGATA
+
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
@590292a1-4773-4c91-980c-12a92bc57204
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAACCTCTAAACACCTCTTTCTTACACGCGTGAGCAATGATTAGATCTTCTATTGCGCCATTCTTGTTTTCTGGCATGATAAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGTAGTGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAAACGATTCGTCGGCATCGATGATTAAAGAATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCCTAAGGGTTTGTTTAGTTTTTGTCTGCATTTATTTTCCAACTATAAACATGTTAATTCCTTCTATTTCAAGTAGATTGCAAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTTTATAATCATTTATTTTCTCAGTTTCTACATTTATCTCACCTCCCAGCCATTTTCAGCACTGAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTGAGATTCGCCCCTTGTCTTCCAGTCTTATGTAAGATATATCTTTTCTTTTTCAGCCAATTCGTTTATCGCACATACATCATGGCTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCTATCTTTGATTACTGAGTAGTGAATTCCATTTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCCTAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTAACTCTATTCTTTTTGGGTTGCCTATTATTTCATCTTTTCTTTTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGTGGTTAATATCGCTGCGGTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTGTTATCTTTATAGTAATCAATTCTTCTTCTGGAAGTTCTTTTTCCGTTCTGTGTTTCACTTTAACAGCAATCATTAAAACATTCCCACTTTCCTGAGGCCGAGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGAGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTACTTCTGACCTTTCCATCTCTTATTGTTATGGACAGCATTTCTTTGGATGTATCCATGTTATAAAAATAGCTATCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAGAGCTTTTTACTTTTAACAAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCATTTTATGACGTAAACACCAACATTTGTCTCTTATACACATCTGGCCTTTGCCGACGACGAA
+
.+,+**-775>J(=8:@A8861..045>=6D5A1@</131*$/-067987E:7AF)>+/*29<*&)175128AC733D6FG@A@CC:;DA12-,7&9@DD>9=347:9.1)<4/,@=DE-:2,;:)8>@ABCC@>@77:D.7''.8,=A@<887.33'3AAD>>EE19)&&)34*:?CFG=AE=A?@O9=?A=540&&*##$$#$%56>AK;<JA./5>@94:;;>?;<<556<<<B*'@?B:<EA?15-D-+,*-206=5>9;=:$%.927D<9@00=<;FA,,$&*99@;@:<?ABKIMJFC89;899)3?A9.44..7;=GBCD?2217&)0.//;?ACC@>=A7==?PFC633'&<;>?A;DDI@)/5328)%-.(*)-)::@BCB56=3<24332E687823128.6:;0-9++B@B<C@=C72;421009343048@F>88BRCRMF@A>E>?;@?@CC>>FE=9:809DD:,(';<EFEB::*79369'/-//;<=@BI:+-%%%&*)):0&'..GBB<B?:;A:<<DB>=88A49=HJ@CE:3*;9GILA@8436&4$$$$#$%&*'/0*5489A;72010((-=8=2>78C?>A9DAFA1%$$),0104107BE95?.565@A(@3<@5)-211%*'341@D=;<>B99GEGFCEG???77;28CGQEE<CDE>D:BAD>?@B&-=<FDB?>A96>@ID>97?5/5-*%'$%$()'/AB47=CDMGB4CFBEAC==H>>;FD;7F<),),3+(7:A?@:4)21:8;CG=@BA:8:>3+,1-,,($((.0/2>?7/2/010/848@@3)(=7:6?HHH@@G>GD@4?CDA?AFA:1./11255=?944''-$678?8:?A<<0/=BC@:>AD;:>?C4E=?8DD=?9::;:>:IF=A8<C8702%/#$#+<798DDCA6*/6AB:?>B:C<5@>EC<<<24IB859SJKJG302166();<<<<K@AD=769IFa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
@427c291a-20ef-413b-b2c8-37c33360028d
CTGTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCGGCAGCGTCAGGGTGTATAAGAGACAGTCTAAACACCTCTTTCTTACGCGTGAGCAATAGTTAGATCTTCTATTGCGCCATTCTTGTTTTTTCCTGGCATGATAAAGTGTGCGTGCTTCCGTTAATGGCTATTTCGGCATTATGCGAGCTTGGTGATGATCGCTAAGCTCGTTAATGTTGAAATTATCGATCTTTCCGGTAATCGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTCATTAAAGAGAATCTATAACTTAAATGCTCTAAGGGTTTGTTTAGTCTTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACACCCTCGAAAATGACTTTTTATAATCATTTATTTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGGTCCTTGTACCAACCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCGCACATACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGTTTGCTTCCTATTAAGCGTTGATCATATCTTTGATTACTGGGTAATAGTTATTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTTGAACTAAGATTAGACTAATGTCGAAAGACGCGCTCTGCCTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTACATATATCAAAAAATCTCTTTGTTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTAATATCTATTCTTTTAGGTTGCCTAATGGCCTTCCATCTTTTTCTTTTGCGTATGAAGCAGAAGTACGAGTGAAGTTTATCATTTGTTTTACCATTTCATGGAAGTTTGATTATATCTTTGGTTTTTGATTTATGTTATTTTTTTAAGTTTTCCTGTTTGTTTATTTCTCAATTTTTGTATTTGAAGATATATTTATGAAGTAATCTCAATTCTATAAGGGAGTTAACTTGTACGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCTTTTCTAAAATGAGGTTTGTCTGATAAGGGTGTTTTGATAATGACTCAACATTGAGGATACAGCGTTCGCATTGTGTTATCCCATCGTTGAGTATTTTGTGATACTTCTGACCTTCCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAATGGTTTTCTTTATTTAAAGGAATTGCTTCATTTCTAGCTTTTACTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTCCCAAAGTTGTTTTCAGATATTACATTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCTCAAACATAAAATTTTTAAGTGGATATCTTTTTTATCGTGTTTAAACTTTACTCTCATTTCTGTTTACGTTTGTAGTAATAATGTGTTTATTTATCATCACTAACTACACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCCTACGTAATCTCCTGAAGCTGTGAAAACAAAAAAAAGAAAAAACCACCTGGGAAGTGGTTTGATCGAAAGGTTAAATCCAGTTGGGGAACTGCCAACAGGATTAACTGTCTTGTGCAGAGACGAGTCACCAAAACTGTCCTTTCGGTAGCTGTAGTCAGGCCATCGCCAGATACCTCTCTTGAACCTCTCGCATCGACTTTAATGGCTGCTGAGTAGCGCCTGTCGTGTCTTACAGGTTGAGACTCGAAACGATGATTACCGGATAAAGGCGGCGGTCGGGCCTGAACAGAGAGGTTCGTGCACACAACCAGCTTGGAGCGAACACACCTACACCGAACCGAACCACCCCCAGCGGCTGAGCTGGAAAGCCACGCCGAAGGGAAGCGGACAGGTATCCGGTAAACGGCAGGAGTCGGAACAGGAGAGCGCACGAGGAGCTTCAGGAAATTACCTACGGTATCTTTATGGTCCTGTCGGGTTTCGCCACCTCTGTAACCCGGGCGTCGATTTTGTGATGCTCGTCAGGGGCAGACTGAAGCGCCTGCGGCACTGGCTTCCCTCAGTGCTTTGCTTTTGCTCACATGTATACACATCCTGACGCTGCCGACGACAAGAGTGCGCGCGCAACAATGCGTAA
+
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
@d3bfecb4-a0fe-4f41-b1bb-bf54666d97a6
GTTGTACTTCGTTCGGTTACGTATTGCTGCGCCGCATACCTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACATTGATAAAGAAAGATATTTTTGTGCGCTTCCGTTAATGGCTATTTCATTATACGACTGGGCTGATGGAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGACAATAAGAAAACGATTCGTCAGCATCGATGATTAAGAATATACTTTCTTTTTCCATTTAAAAGACTCTATGCTTTTAAATGCTCTAAGGTTTGTTTTAGTTTTGTCTTTCCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACTAATGTTTTTTATAATCATTTATTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTCAACTGAAAAGAAAAATCATCTCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTTTTCATCTAATTCGTTTATCGCACATATTACATCTACATGGCTGTGTGTTATTTGTAAATATTTGATTATTATTGGTTTTGCTGTAGCTATCAAGCGTTGATCCTTATCTTTGATTACTGAGTAATGAATTCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTGTATTATCAGCTGCGGTTTTTGAATTCCTTATAGCTTACCTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTGTTATTTTTAGTAATCAAATTCTTCTGGGGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCCTGAGAGCCGAGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCCAGCATTGAGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCCTGACCTTTCATCCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTCCTTTATTTAAAAGAGATAGCTTCATTTCAAAGCTTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTAATATCGATGTTTTCCCCAAGTTGTTTTTCGGATATTACATTAAGTGTTTTTAGTTGTTTGAGAGATTATGCTCTCGAAACACTTAAAATTTTTAAGTGGATATACTTATCGTATTTAAACTTGCTCTCCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTGCTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCTAAACTGAAAACGAAAAAAACCACCTGGGGAGGTGGTTGATCGAAGGGTTAAGTCAGTTGGGAACTGCTTAACCAGGTAATGTCTTGTGCGAGACAGGTCGCAAAACTGTCCTTTCAGTGTAGCTGTGGTCAGGCCATCACTTCAAATTACTCTCTTGAACTCGCACATCGACTTTTACCAGTAGCTGCTGCCGGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGTGGTTACCGGATAAGGCGCGGCGGTCGGGCTGAACGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCTACAGCGTGAGCTATGAAGCGCCACGCTTCCCGAAGGGGAGAAGGCGGACAGGTATCCGGTAAGCGGCAGAGGGTCGGAACAGGAGAGCGCACGGGGGCTTTCAGGGAAACACCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGTGGGCCTCGGAAAGCACCTGGCGCTGGCTTCCTCGGTGCTTTGCTTTTTGCTCACATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGAGTGAGCTGACACCGCTCGCCGCAGTCGAACGACCGAGCGTAGCAGTCAGTGAACGCGAGGAAGCGGAAGAGCGCCTTATGTGACATTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGAGTTCTTCTGCCGAGTTCGTACAGCTTCTCACGCACCAGCAGCCTGTTCGTCAGCATCAGGTGCGTCCAGTTTTCGGTAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTCAGGTACGGCGCACTGCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTGACGGGCGTTTCTGTCAGACAACACTGTCGCTGCCAAAAAACTGCCGTGCGGTTTTGTCAGTATTCAGGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAAGACTTTGCCCCGACACCCATGTCAGATACGGAGCCATGTTTTATGACAAAACAGGAAGTGGAAGTACGCGCAGGCAGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTTCCGGTTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAAGAAAAACTCTTTATCGACAGCAAGCGATGTCGAGGACAGGGGGAGTATGCGGGAGGTGCTGATCCCCTTCTAGCCACGAATAATATCACCGTGCCCTGTTATCAGACTTATAGCAGATTGAAAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCCAAGTGATCATCATTCGCTTTCATGCATAGCGAAAACATACACGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTCCCGGGGTAAAACATCTCTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAACGCGTTTCAGCAGTGCGTACAATTACAGCATTATGTTAAATTTACTAATTGTCTTTAGTCATTGCGCTATGATTTTGTGGGTGGAGTTGTTCATATTTTTGAGTATAAATTCTTTTTTTATCTCACTGGAAGCGGTCATCAATCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTATGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAACGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATGCCTCTAACCTCTTTCTTACGCGTGAGCAATGATTAGATCTTCTATTGCGCCATTCTTGTTTTTCTAGCATGATAAGACTTTGTCTCTTGCGGCTCTCCAGGCCACGAGACCAGAGAGTGCGCGCCCAGCAATACGTAAC
+
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
@177decf1-27b1-4f71-845e-2844a2dede11
GTTGTGCTTCGTTCAGTTACGTATTGCTGCGCACTCTCTGGTCTCGTGGGCTCAGGGGAGATGTGTATAGAGACAGGTTAAAGTAAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAGAAAACTCATTTTGGGATAGCTATTTTTATAACATGGACACATCCAAAGAAATGTCCATAACAATAAAGATGAAGGTCAAGTAACACAAAAATACTCAACGATAGATAACAGACAAGTGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAAGGAATGTTTAATGATTAAGGTTAGTGAAACACAAGAACGGAAGAACCCCCAGAAGAATTGATTACTATAAAAATAACACAAAAGCACAAGAAATAAACGGAGAAATAAAACGAAGCTAAAGGTAAGCTATGTGAATTCAAAACCGCAGCGATAATAACCACATCAAGAAACATAAAACAAGAAGCAACGATAAAAAACGTATCAAAACTACTAACACAAAAAGAAAAGATAAATAATAGGCAACCTAAAAGAATAGATAATAGAATTAACAGTATATTGCAATAATAGCAACAAGATCAAAACAAAGAGATTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGCTTGGTGAAGGCCAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCAGCGATAATCAAAGATATGATCAACGCTTTGATAGAGCAGCAAAAACCAATAATAATCCAAATGTTACAACAACACGGCCATGATGTAATAATGTTGCGATAAACGAATTAGATGAAAAAAGAAAAGATATATCTTACATAAGACTGGGAAGAAGCAAGGTCTCAAAACCCACAGCAATGCAATTTAACATGGATGATTTTCTTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAGTGAAACCGAGAAAAATAAATGATTATAAAAAGTCATTTTCGTTGAGGGTGATGATGATTTTCACTTCCTTTTGTCTACTTAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACAGGAAAGATCGATATTTCAACATTAAATAGGCTTAACATTCCATCACCAGCTCGCACTTAATGAAATAGCCATTAACAGGCTTACAAAAATATCTTTCTTTTATTAAAAGACACTATGCTTTTAAATGCTCTAAGGGTTTGTTTTGATTTTGTCTTCCATTTATTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCTCAACGAAAATGACTTTTTTATAATCATTATTTTCTCGTTTCTGTTATCTCACCTCCCAGCCATTTTCAGCTGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAAATCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTATCACACGTATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTGTGGTTTTGCTGCTTCTATCAAGCGTTGATCATATCTTTGATTACAGGTAATGAATTCCATTTCTATCTCATCAATGAGAATA
+
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
@c182bd3d-66e3-4c7a-91e6-97d3bf72186a
CAGTGTACTTCGTTCAGTTACGTATTGCTGCGCGCCTCTCTCAGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGGAGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAACAAAATGGCGCAATAGAAGATCTAATCATTGCTCACACTTTGATATAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAGATAAGCCATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGGCAATAAGAATCAGATTCTAGAATAAACCATATCAATGAAGAACAAAACCGTGATACCACTGACGATGACTTCCAGCCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTCATAAAATTTAACATAATGCTGTAATTGTACGCACATGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAAGAGATGTTTTACCCAGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAACTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAACACCTCCGCATACTCCTGTCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCCAGTCTCACTTAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCGAGAGCTGCCGCCCGTAAAACCGGAAACAGTCTTGCCGCATTCAGCAGCCCTTTTTCTGATTCCTGGTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGTATTACTTCCACTTCGTTTGTCGCATAAAACATGGCTCCGTATCTGACATGGGTGTCAGGGGCAAAGCCCTGATCAGAACCAGTGTAATAGCGTGCATGTAGCCATGATATAACAATTGCACACCTGTCCTGTCAACCGAAGCTCAGATACCGACAAAGGCACGGCAGTTTTTGGCAGTGACAGTGTTGTCTGACAAGAAATGCCCGTCAAAAGCCAAGCGGCAGAATAACGGCAACAAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGATGAAGGCTCGGAGAAAACGAAAAGATGAATTAAGCAGCAGCAAGCCCGTACTCAACATGGCGGGATTCATAAAAGTCAGAGCCTGACGCTGCTCCGAAAAACTGGACGCACCCGATGCTGACGAACGGGCTGCCATGTGTGAGAAGCTGCACGAACTCGCAGAAGAACTCCAGAACAGCATCCAGACACGCTCTGAAGTAGAAAATAGCACAGAGAGATAACGCTCAGGACAGGGTGCCGAACGCTAACAGAGCGTAAGGAGAAAATGTCACATAAAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCAGCTCACTCAAAAGCGGTAATACGGTTATCCACAGAATCGGGGGATAAAGTCGGAAAGAACATGTGAGCAAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCGAGGCGTTTTTCCATAGGCTCCGCCCCTGACGAGCATCACAAAATCGACGCTCAAGCCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACAGGTGTTTCCCCTGGGGCTCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCGGTTCCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCAACCCGGTAAGACACGACAAAGCGCCACTGGCAGCAGCCATTGGTAAAAGTCGATGTGCGAGAGGTTCAAGAGAGTACTTGAAGTGATGGCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTCCCCAACTGACTTAACCTTCGATCAAACCACACCTCCCCGGGTGGTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTGGCATAGTGATGCATAAATAAACACGTATTACTATGTAAACGTAAACAGGAAATGGAGCAAGTTTAAACATGATAAAAGATATCCACTTAAAAATTTTAAGTGTTTCGAAACATAACTCTCAAACAACTAAAGACACTTAATGTAATATCCGGAAAAAACAACTTTGGGAAAACATCGATATTAGACGCGATATTTTCATTTTATGACGTAAAAAAACCCAGCAGCTCTGTTAAAAGTAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAGAAAACTCATTTTGGGATAGCTATTTTTATAACATGGACACATCCAAAAGAAATGTCCATAACAATAAGAGATGAAAGGTCAGAAGTAACACAAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGCTCTCAGGAAAAGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAGAACCCCCAGAAGAATTGATTACTATAAAAATAACACAAAAAGCGCAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAGCTATATGAATTCAAAACCACAGCGATAATAACCGCATCAAGAAACATAAACAAAGAAGCAACGATAAAAAACGTATCAAAACTACTAACACAAAAAAGAAAAGATGAAATAATAGGCAACCTAAAAAGAATAGATAATGAGATTAACGATATTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGCTTGAGTGAGGAGTAAAGCAAGAGCGCTGTCTTTCATTAGCTCAATCTTAGTTCAAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCAGTAATCAAGATATGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAGAAAAGATATATCTTACATAAGACTGGGAAAGACAAGGAATCTCAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTCAGTTGAAAATGCTTCAGAAGTGAGATAAATGAAACCGAAAAATAAATGATTATAAAAAGTCATTTTCGTTGAGGTGATGATGATTTTCCACTTCGCTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAAGAGCATTTAAAAGCATAGAGGTCTTTTAATGAAAAAGAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGGTAATTTCAACATTAAATGAGCTTAACCTGTCTCTTATACACATCTCCGAGCCCACGAGACCAGAGAGTGCGCGCGCAGCATGATACGTAAC
+
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
@c97f4f45-ca13-4f23-b784-e807a9f66da6
GTTGTACTTCGTTCAGTTACGTACTGCGCGCACTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCTCGCATAATGGAAATAACCATTAACGGAAGCACAAAAATATCCTTAACTTTATCATACCAGGAAAAACAAGAATAGCGCAATAGAAGATCTAATCACTGCTCACGCGTGAATAAAGAAGAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGGCTGCTTCAGTGAGATAAAAGAATTTATATCAAAAATTATGGAAACAACTCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAGTTTAACATAATGCTGTAATTGTACGCACCGCTAAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAGAGATGTTTGCAGGAAAACGGAGGATGCGATCAGGATCGTTTTCAACTCGCTGCATAGCTATGCATGAAAGCAGATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACGGGGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCGCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAGAGTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTGCGGGAGCCTTCACCGCCCGTAAAAACCAAACAGTCTTGCCGCATTCAGCAGCCCTTTTTCGATTTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAACCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCATAAAACATGGCTCCGTATCGAGCATGGGTGTCGGGGCAAAGGAAGCCGAGCCAGGGCAGGTGTAATAGCGTGCATGTATGCGCGGTATAACAATTGCATCTCTATCAGCAAGCTCGAATTACCGACAAAGGCGGCAGTTTTTGGCAGTAGCAGTGTTGTCTGACAGAAATGCCCGTCAAAAGCCAAGCGGCAGAATAGCGGCAACAAAACAGTCAGAAAAGTGGTACGCGATATAATCACACAACGCCAGATGACAGACAGAACGGAAAACGAAAAGATGAACAAACAGCAGCAAGCCGTACTCAACATGGCGGGATTCATAAAAGTCAAGCCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTACACGAACTCATGAAGAACTCCAGAACAGCATCAGACACGCTTTGGAAGTAAGAAAATAGCACTGAGAGATAACGCTCAGGACAGGATGCCGAACAGCACAACAGAGCGTAAGGAGAAAATGTCACATGGAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTACGCTCCGGTCGTTCGACTGCAGCGAGCGGTGTCAACTCACTCAAAAGCGGTAATACGGTTATCCACAGAATCGGGGATAAAGTCGGAAAGAACATGTGAGCAAAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCAGGCGTTTTCCCATAGGCTCCGCCCCCTGACGAGCATCACAAAAATCGACGCTCAGAGCCAAAGAGTGGCGAAACCCGACAGGACTATAAAGATACCAGGTGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCACCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCCGCCTTTCTCTCCTTCAGAGGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAAGTCGTTCGCTCCAAGCTGGGCTGTGTGCACCGAACCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAGCCCGGTAAGACCGACAAAGCGCCACTGGCAGCGGCCATTGGTAAAAGTCGATGTGCGAGAGGTTCAAGAGAGTACTTGATGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTGAGCAGTTCTAGCGGCAACCTTCGATCAAACCACCTCCCAGGTGGTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCCAAACAGGACTATAAAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTATATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGGGAAATGGAAACTAAGAGTTAAAACGCGATAAAGATATCCACTTAAAAATTTTAAGTGTTCGAGAGAACATAACTCTCAAACAACTAAAAACACTTAACGTAATATCCGGAAAAAACAACTTTGGAAAACATCGATATTAGACGCGATATTTTCATTTTATGACGTAAAAAACCCAGCAGCTCTGTTAAAAGTAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAAGAAAACTCATTTGGGATAGCTATTTTTATAACATGGACTTACATCAAAGAGATGTCCATAACAATAAGAGATGAAAGGTCAAATGCTTACAAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCTCCATTACGACAAACCCTCGGCTCTCAGGAAAAGGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAGAACCCCAGAAGAATTGATTACTATAAAAATAACACAAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAGGTAAAGCTATATGAATTCAAGGCACTGCGATAATAACCACATCAAGAAACATGAACAAAGAAGCAACGATAAAACGTATCAAAACTACTAACACAAAAAGAAAAGATGAAATAATGAAACAACCTAAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAGCAACAGATCAAAACAAAGAGATTTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGCTTGATGAAGGAGTAAACAAGACACTTTATCTTTCATTAGCTCAATCTTAGTTCAAAAGACTCAATTATTATTCCTCATTGATGAGATAGAAAATGGAATTCATTACTCAGTAATCAAAATATGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAATAATCAAATGTTACAACAACACACAGCCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAAGGAAAGATATATCTTACATACAAGACTGGGAAGAGACAAGGAATCTCAAAAACCTACAGCGAAATGCAATTTAACATGGATGATTTTCTTTTCAGTTGAAAAGAAATGGCTTTTAATTGAGATAAATGAAACCGAGAAAATAAATGATTATAAGAGTCATTTTTCGTTGAGGGTGATGATGATTTCACTTCCTTTAAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAGAAAGTATATTCTTAATCATCGATGCCTGTCTCTTATACACATCTCGAGCCCACGAGACCAGG
+
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
@ab13b84d-2005-40f6-80ec-058d421f6dc2
CGGTATGCTTCGTTCAAGACACGTATTGCTGCGCACTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGAAAAGACTCTACCTTCTTTTCAAATGCTCCTGAGGGTTTGTTTAGTTTTATCTCTTTTTCATTTATTTTCAACATAAACATCAATATTAATTCAGCCTATTTCAGAGTGGATTGCAAGGTGAAAATCAATCATCACCCTCAACGAAATGACTTTTATAATCATTAGCATTTTCCTCGGTTTCATTTATCTCTCACCTCCAGCTGTTTCAGCTGAAAAAGAAAAAATTGTCATAAATAGAACCTAGTTTGCCTTAGGTTTTGAGATTCTGTCTCTTCCCAGTCTTATGTAGATATATCTTTTACTTTTTTCATCTAATTCGTTTATATCACTTGCATATTACATCATGGCTGTGTGTTATTTGTAAATCTTGATTATTGGCTGGTTTTTTACTTAGCATTATCAAAGCGTTGATCCATATCTTTGATTACTGATAATAGATCCATTTTCTATCATCAATAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTACTTTACTCCTTCCACAAAGCATTGATATTTGTTTAATTCATAGATATATATCTAAAAAATCTCTTTGTTTTGATCATTGCTATTATTGCAATATCTGATTAATTCTATTATCTATTCTTTTTAGGTTGCTATTATTTCATCTTTTCTTTTTGTATTTAGTAGTTTGATGCGTTTTTTCTCGTTGCTTCTTTGTTTTTACTTGTTTCTTGATGTAGTTTATTATCACTGCGGTTTAGTTCATATAGCTTTTACCTTTTTAGTTTGTTTTGTTTTCTCCGTTTATTTCTTGTTAAGCTTTGTATTTATTTTAGTAATCAAATTCTTCTGGGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAATTCCCTTTTCAGGAGCTTGAGGTTTATCGCAATGGGGAGGTGTTCAGACTAATATTGACTCAGCATTTGAGACCACGCTCCAGTTCACTTTGTGTGACATCTATCATTTGATATTTTTTATGTTACTTCTGACCTTTCATCTCTTATTATTTGTGGGTTTCTCTTTGGATGTCCCCATTATTTATAAAAATAGCTATCCCAATAAGTTTTTCTTTATTTAAAAGGGAATGTTGTTTCTAAAGCTTTTTACTTTTAACAGAACTACACTGGGTTTTACATCATAAAAAGGTAGAAAATATCGCGTCTAATATCGATGTTTTTTCCAAAGTTGTTTTTCGGATCTTGCATTAAGAGTGTTTTGGTTGTTTGGGAGTTATGCTCTCAGAGCTTGCATAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCTGTTTCTGTTTACGTTTACGCAACGTGGCTAGTATTAACTGTTTCATTTGTAAACTCACTTTATACCTGTTTCTTTTCGTATAATCGAAATAATATTACTACTTTATAATTCCTGTTGGATTCAAGTTTTAACCCAGTTTGTCGGGTTTCTTACTTGCGTTATTGTATTTCCTAATTCAGCGTCTCTAAACTGAAAACGAAAAAACCACCTGGGAAAATTGGTTTGATCGAAGGTTAAGTCGGTTAGGGAACTGCCAGCATATGATGTAACTATCTTGTGCGAGACGAGTCACCAAGAGCTGTTCGCTTTCAGTGTAGCTGTATTCAGAATTATCTTCCAGAGCCT
+
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
@32dc5a60-b25c-4228-83b9-2d850b8f6aa1
CGACGCCTTTACCATTGGTTATTGTTGCGCACTTTGCGCGCGCTCTCTGGCTCTCGTGGGCTCGGAGATGTGTATTATGAGACGGGGCTTTTTAAATTCTCTAAGGGTTTGTTTTTAGTTTGTCTTTCCATTTATTTTCCAACTACAAAGCATCATTAATTCAGCTATTTCAAGTGGATTGCAAAGGTAAAAGTCATCATCACCCTCAGCAAAAGTGACTTTTTATAATCATTTGTTTTCTCGGTTTCATCTCACTCCCAGCCATTTCGAAGAAAGAAAATCATCTATTAGGTGCCCATTGCATGGGTTTTAAGATTCCTTGTCTTCCCAGTCTTGCTCACTTGAGATATATCTTTCTTTTCCACATCTAATTCGTTTATCGCACAGCATATTACATCATGGCTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGGCGAATTATTAGTTCATTTTCTATCTTTCATCAGTAAGGAATAATTGAACAGTCTTTTGAGCTAAGTTGGGCCCACAATAGTGAAGGGTGAAAAGAAACGCTCTACGCCTCCTTCACCAAACATTGATATTTCATTTATTCACTTGAGTCCTATATCTAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCGTATGCGTTAATTCTATTGTATTCTTTTTTGGGTTGCTGTGTTTAAATACTTTTCTTTTTTGTGTTGAAGTTTTGATGCGTTTTTTATCGTTGCTTCTTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCACTTTTTTGGTTTGGATTCATATAAACACACCTTTTTTGGTTGTTTTATTTCTCTAGTTTATTTCTTGTGCTTTTGTGTTACATTAATACACATATTTATTAATCAATTCTTCTGGAGGTTCTTTTCCAGTTCTGTGTTCATAACCTTAATCATTAAAACATTCCACGCACCCTTCCGCGAGAGCCGAGGGTTTGTCGCAATGGAGGGTGTTTGATATTGACTCAGCGGCATTGAGGACTGCGGCAGTTCTTTTTATTGTTATCTATCACGTTGAGTATTTTTGGCTATTTACTTCTGACTAATTTCCATCTCTTATTGTCATGGACATTTCTTTGGATATGTCCATGTTATAAATAGCTATCCCAGTAGGTTCTTTGTTTAGGGTATTCATTTCTAAAGCTTTTTTTACTTTCCCAACAGGCTGCTTTTGGGTTTTCACGTCATAAGAATGATCAGCGTCAATATCGATGTTTTCCCAAAGTTGTTTTTTCGGATATTACATTAGAAGTGTTTTTAGTTATTGTTTGAAGAGGAGTTAGCCTGCTCTCGAAACGCTAAAATTTTAAGTGGATATCTTTTTATCATTTTAAGCTTGCTCTTTTGTTTCTGTTTTGCAGTTACATGTCAGCATTTATTTATGCATCCGCTGCCTGTTTCTTTCTGATATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGGTTGTCTTGTGATTATTGTATTCTGGTCATGCGTAATCTCCCTAAACTGAAACTTTGAAAAAACCACCTGGGGTGGTTTGATCTTTGAAGGTTAGTCAGTTGGGGAACCTTGCTTAACCAGATGTATCTTGTTTGCGGAGACGAGTCGCCCAAAACTGTCCTTTCGGTGATTTTCTATTATAGCTGTGAGTCGAATCACTTCAAGTGATCTTTGAACCTCTCGCACGTGACTTTTACACACATGACTTTAGCAGTGGCGCTCTTTACTGTCGATATCTTACTGGGTTGGACTCAAGACAGTAGTTACCGGACAAAAGGCGCGTAGTCCAGGCCCGAACAACAGGGTTCTTTGCTGGCCAGAGCGAACATTCCTACACCGGACAAACCGGGATTCACCTGGCGTGAGCTATCTTGAAGCGCCACGCTTCCCGAGAGGAGAAGGCCGGACAGAATCGGTAAGCGAGGTCAGGAACAGGAGGCACGAGGGCAGACACCTGGCTGTATAGTCTGTGGGTTTGCCACCTCTGGCTTGAGCGTCGGTTTTGCTTGATGCTCGTCAGAGCGGGCTTTATGGAAACATGTGGCGCTTTGTTTTCCCTCCGGTGCTTTGCTTTTTGTAAATGGGCTATTTCCGGCTTCGCTGCACCTTATCCGGTAACTATGCGTCGTTGAAAGACACGACAAAGCGCCACTGGCAGCATGCGGTGGTAAAATCGATGTGCGGATTCCCATGCGGTGATGGCCTGACTGGCTTCTACACTACGAAGGACAGTTTTACGACTCGTCACTAGAGACCAGTTTACCACTGTTAAGCAGTTCCCGAGCAAC
+
)-+))&((,*##$$$%%(%'#$'%0*)%))&',,22./%'##$),-8843',;;@:B1100(8&*#--4--,$$$&./*&+&&%&%+/01851**'((#%)(%%+05)1:+.4?<5-812-'67<<>+1,./432441$+**&&#&./5&:6/:9;>56412,,.139:74()%5)+)28$+*,&,(0$&$'&$$'.10.-+--,*(%%'+,)%%+)'110++(&&02*2-132%(()2).6).9>=:=7807**6,5384;:6;@/-%%%$%*'&4-43.5*$,#%(+(%$)"##(*03%%''$(4>>=5#&&)0()#$'$0254238266783%"$%$#&&().95522=?DBF@?==7&%#$)/4-+,+332=AC5-6**('%',0888824;:7($)('1(609<1;@8A56)()//4..><3C?2CC./7COE.CF>:>A@C97>(+&$=<A@>5.=3===?KHEA?N4&$$$$$$'$(,$$$$,$'2%.2C>:82(*87-370.9%%%%(//59./.0%$)#%,46*,30.*',*&&3%'-08;5/..68'6$(%%''(,+/*+&$%&&%%$*5.+$'##$-125*2&%&%)%/((+**1,DCD>7::(&)*-9--/''+%%)4=?;66+**42643;139A<CC8558<A/BA;<9::<2>9'(&'(%##&$%5657@7637,206-+****,+*/7,-#%&&('((,---.2255552.-/..,')&.0..-;?AI4-*'&+()9PH;@<32+8:1024/./.+5:B6CCD?<<>=H?CB@;848,3'*0.4+'/#%''&&&&*,A@-(*/74,,%%*(*&%'%'(()03333().9)'6GA:ABF9*9&&,3645=AE>?>.0)-4555(4*26**()'#$'$#$%'&(#&'$&&,20B342=>?=:41/&'9>1(34:;%*)00:??9@870;0<772522::31$+,01./.&.2+*%)####%"$$(,%%%&%),...,694;A'%;@8?BCC880',+99@AB87-6%)145:1,&%%&+'+/1/1%&%$#%(+,,-<<927<</$&'$3698;;2.8*.--,/)-76EA990$%"$$+,*.*+083=5)%#&%')$(;6<*7@8015/9<5A;?B@>??D579:466(%',113/0.-/11395+5+445''.')$+''2685999%..+(%)%''+-)3,2/01253+9::D@?>:1--1'$&&))+'$%%+$%)-85+.2:;</&$-63,'*&($$'%$%')%%/-(&12;5012265&*<9220'(&/>C16AQND)?5<E>@:>9;>@2(%*(3A>;>NH4-773+:=07;4,*%'&$$&6/05,+*&$$1211,,0+/&&101/.*1//*/-A=@>5<9:B@>>8;99,'+=8//&2232+,40/++,/12,-)2545$%#(.4-.),%$&##$#&'(*..0*++3622912>(/-.+%&+&&406//.?CBBC;??A;F<'+**788333*3673&&-');>D68-,,*)@B>700275686>//.$*:54$(####+++07122*''2546589:-$$13478783++(/%&(%%%%%%"$%'(,55421/.0659%(7):+266670$'##$'%$%)+2-095,8;<168854'%#%%()*00+/&-'&&#'7=98&&((&3%($0+*/&3'2,&00(,%$#$$%%0%'*/#',)(&(())%$$$$$&'*/%*('(1/#%&&&$"#$$$'%,)#'&%&'%&)05/',($'%-02121111*&%)&,.',&$$'(*+$*%)'%((%"%#$$'&&,-98-.3.9>=<842*+8=>>BE=/85666.&%(%918657)**&,--%)--%&$#$$''6*:2)**)(+1$$)$&$&%),-.-%#$$$$$$0*,5'',.)))#%'/5..8-24.,+''.#&(-.0%#$%$#%%&&'$*,$'&##%-+-499<:6=2)))*8'+$)&(*,(//*5$=:>8()%$&1:)-+$$&'%$'/0/$//.3+'7/*%'(035.3('%$$*'*:93.,$(&(2233/4*))(,1,,*$23.017/--/))))(7=65@/1DB=8+$$,20B0*8>?;3*,',1%)-$$'-''*,(&%-&%$#&(1%$%&,%&'&&/3*.+?*3<;123>1577<7/)))*&)$*.,-*(&&%)*-()('$#()&%&&'2;9:D08B=3/-&&$&&(&&',,(%$+.4%*<DCFF6<<;;?=;:43,$%+$##&&+5*--((''373)$$%.7%(&%&&-*&#$$#$))8>*3+0&'',(''"$+$%36'',#'''30C=+&:998.-)%%))&,,3'%$'$&++'(%'=@1*8366027:44%.+4:9580%'%),+%
@1b4e4b37-207d-4cc2-a4b0-1b7673c1d403
ACCTAAAAAGAATAGATAATAGAATTAACGATATTGCAATAATAACAACAGATCCACTGAAGATTTTTAGATATGGGACTGGGGTGATTGGAAGCGATAATCGATGCTGATGAAGAAGAATAGCAGAGCGCTGTCTTCATTGGCTCAATCTTTAGTTCAAAGACTCGATTATTCTCGTTGATGTCGAAGGATTGAGATATGATCAACGCTTTACGATAAACAGCAAAAACCAATAATATAATCAAATATTTACAACAACACGCGTATGATGTGTAAACAATTAGATGAAAAGATATAATCTTATAAGACGGGAAGAGACGAAATCTCAAAAACCTACGGCAATGCAGAACTGGCGTGGATGATTCTGGCTTTTTCGGTTGAGAAATGGCTTTCAAGAGTGAATAAATGACCAATAAATGATTATGAAGTCATTTCGTTGAAGTGATGATGATTTTCACTTCCTTAATCTACTT
+
2947DKP;',@?<::DCAA,)5*1-4..3%%)%''%'(*+%'$#&*(+301:''*&')/&&%%./--*%*#$#$&+25$$#%&')-)'+#%%%(''(*')16,**(-0/(.-&.-*(1/2,.&+*+%.1('/).-796*/3/1,-/0410,,&%))-002*'*&4/,($',.25:3%&-3**&$$$$&$%##%))$(**%($/5))+%$&''#)()3699-*21,-)%&&+-,)%)$'%%'-0)+1+/554&'#$)&'&''$)##&%&)*$$%'+,)*#$#$&$-/0484'%)('(',*+('(*'($$%%*9/1.'(+$/00;:?86-//--86<6=&.89<42)%%$$#*$*1&.,.1(0%$%#%#%$(/8828$&(//1%%(01$$%%&&%#$%%$)+*11*,+*))$)$&*-.-631&*-'$*)-5/188==:://(%*-/*$)&$(%6:=690/00,-,('*792-$$&
@57c7eb5c-e075-4372-9537-3145f276b794
GTTGTACTTCGTTCGGTTACGTATTGCTTTTGCACTCTCTGGTCGTGGGCTCGGAGATGTGTATAAAGACAGAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGGTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTCATCTAATTCGTTTATCGCACATATTACATCCATGGCTGTGTGTTGTTGTAATGTTTGATTATTATTGGTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTCTGATTACTGAGTAATGAATTCCATTTTTCTATCATCAATGAGAATAATTAGATCTTTAAATAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTTACTCCTTCACAAGCATTGATATTTCATTTAATTCCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCCTATTCTTTTAGGTTTGCCCTTTATTTCATCTTTTCTTTTTTGTATTAGTGGTTTTGATACGTTTTTATCGTTTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATACCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTGTTTCTGTGCTTTTTATGTTTATTTTTATAGTAATCAATTCTTCTGGGGTTCTTTTTCCGTTCTGTGTTTTACTAGCAATCATTAAAACATTCCCCTTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACACTTGTTAAGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGATATTGCTACAGTATACAGCCTTTCATCTCTTGTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAAGCTATCCCAAAATGAGTTTTCTTTATTTAAAAGTGCTTCATTTCTAAAGCTTTTTGCAACAGAGCTGCTGGGTTTTTACGTCATAAAGAATGAAAATATCGCGTATCCTCAGTGTTTTCTGAGTTCATTTTCCGGATATTTACATTAAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTCTGAAACATAAAATTTTTAAATGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTTACATAGTAATAATGTATTTATTTATGCATCTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCAGGTTTCTTCTTGTGATTATTGTATTATTTCTGGTCGTAATCTCCTAAACGGAAAACGAAAAAGAAAAACCACCTGGGAGGTGGTTTGATCGAAGAGTTAAGTCAGTTGGGAACTGCCAACCAGGTAACTGTCTTGTGCGAGACGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGACCATCCACTTCCAAGTACTCTCTTGAACCTCTCGCATCGACTTTTACCAATGGCTGCTGCCGGTGGCACTTACTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCAGGCTGAACAGGGGTTCATTGCACTGGCCCAGCTTGGAGCGAACGACCTACGCCGAACGTGCCTACAGGCGTGAGCTGAGAAGCGCCACGCTTCCCGAAGGGGAGAAGGCGGACAGGTATCCGGTAAGCGGCAGAGTCGGAACAGGAGAGCGCACCGGGAGCTTCCAGAGCACCTGGTATCTTTACTATAGTCCTCATCTCGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCGGGGGGGCTAGACCTATGGAAAAACGCCTGCGGCGCTGGCTTCCTCGGTGCTTTGCTTTTTGCTCACATCGTTTCTTTCCGACTTTATCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGAGTGAGCTGACACCGCTGCGCAGTCGAACGACCGAGCGTAGCGCCCGAGTCAGTGAAACGAGGAAGCGGAAGAGCGCATATGTGACATTTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTTAAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCATGCAGCTTCTCACGTGGCAACCCCTCTTCATGGCGTCGGCAATCGGGTGCGTCAGTTTTCGAGCGGCGTGAGGCTCTGACTTTTTCTATGAATCCCGCCATGTTGAGTACGGCTTACTCTTCGCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTTGACGGGCATTTTCTGTCGAACAAACACACTGTCACTGCCAAAAAACTGCGCGACGCTCGTTAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCATACATACGCTATTACAATTGCCCTGGTCAGAACTTTGCCCCATTTACCCATGTCAGATACGGAGCCATGTTTTGCTGACAAAACGAAGTGGAAGTAATATACGCACTGGAGCCAGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGAGACCAGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTACGGGCGGCAGCTCTCGGTAAGAAAAGTTAACTCACTGACTGATGATCAGGTACTGAAAGAGAAGTTGTAGGACTGGGGGTGTTGAAAAAACTCTTTATCGACGGCAAGCGTATCGGGGACAGGGAGTATGCAGGTGCTGATCGCTAATACGGAGTATCCTGCCGTGCCCTGTTATCAGACTTATGGCAAGATTAGCTTCCCGGAGAAAACTGGCGTCGAAAACAGACAGTATGAACACCGTAAACTCCCAAAGTGATCACCATTCGCTTTCTTTGCTAGCTATACAGCAGGCTGAAAAACAATCCTGACGGCTTTATCTTCTGTTTTCCCGGGGTAAAACATCTCTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAACGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAGTTACATAATTGTCTTTAGTCATTTGCTATGATTTTGTAGGTGGGTTGTTTCGCATATTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAAATCTGATTCCTTATTACAGCTTCAGGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTGGGTAAGCGTAATCGGGATCTAAGGATCTGTCTCTTATACATCTGACGCTGCCAAACGACAAGAGAGTGCGCGCCTGTAATACGTAAC
+
-6:232773()).4$(66,3+3.13)%%%##%%$'(+4=8;91-6A9<ED:6-13BB?4('.39/1&'<7>67B=34,:779;B<=6432553>=002/75/1871/.6CMKTE:9823,&(13//',MGB=,5(,<@39;:<;3///.()*4:?6=4=?@DEN*6''32336'=D=53-.&,)7/&&758:9:A466=?4+4:5'<=/:<M@=45;AD374:=>BFBHC89*/.169>C>?=-.?C>DB=56?>A=8>:;:A/(%*A1@A;:67>=>1+:++..9;<58970$$)%,5<?A<;:>:AA6=?)(*+%%249?>@E=FF;DD8:DDC';?A?F>;1*-802%)*()0'&)?,A=88663$388E=1-+,,2852*+()$,$',/188240,50(+924<=><8C=676/$/$%(%%$%'&%&&.&:31-@CE>B<555()837323>?;7.013(*)068<23&1274CCBC?@DDOO9FBCEHBDF9%)8348;:77:EGC@9;9CPND<9A89@>HHJ<HFJ=DH>?B;KK=E@;270BG5FFEAB;<<GCBB>:<==CJA''(C>>?98?>8+,A?@E898)()))/1,&,;:=BD@:F=53261**95-,6)1BDMEFCB?B9AA[MD943''0BC8345-*9C?FHJE<=DDJF@81-**6+0$1=CDHBEACJ@A<=DFKB?789/,)//17::89?<>BEUL@=398<LE@AMD>EFC=D5:8<;3)1:921,2'/00/6-'++;?A<ACEEAB?=CAD<2@?@>@@Q@@=(,,-<A>CBHIF:<0<+(4191:8>/12,0$*9?<77AA@A6-'-059<:43;@<;=CFD81DD://%(?NMJEBG3395.35))106BDKJGD>E<<=<9=??@>877,)'+,302)+*5=>@=A968EEAAE=EC889<.*-*26;<9?=71;4=;1,'',+%%%$$&$)&+&%'%48>?=?39=A=;:&0-/6DF?CIBCCDFAJDD9<:44/<<>ED66OF=7GKMG?=%&3ACA9;BDIJED;>6:;?OB>JGE@DCDFPI42A?8;9-.:=8:9?A5'//6;;2%./05E<AECD?<=7;EFB?92362.<.7;;3$/+--/092,**-%%%&+##%%'&(/,)+.,*$#%%',%()+*--759=4-)/1++-4501/@@=>NJ:2@@A?DE12),)1+0*)),,,*&%$)))+'1:;16>@<91(*%-03?>A?AE@??<867:981&.0,02.(+/784?@ADEC?7JJ=2,(<=>:12*0>6AAB>CE;;0,BB3'B>/#'$'-(-5>77HHGDGAFGG>EDCC?@?8625DEKC?21<=@FAAD@@7<;>@CKDAH@667F?CDJ>@?GF==?FLD9:8@@;<AH97/&-9OMK@PK?II=EDCHB5?:/*))*'680<401420=<A:;@))2;=7B@B8>?@7))10/+(0-00;85>?>A()-'+-6>CAB?;73?::C')906JR<84,A==47=65.+)()+,162@?;)*;?>>@BC*=79%'%)&*'64<%%<89<8=@@66=5B;735>''/+2?7954/.*3&?;5&&3.014%*673<<@F8=;999:=7(6;;F=):=5DBBLIIB95;CDEBIBF@;=713%0;376()))%%1337>GB=CBABBHA9HK:588,/;./14=:::4DFB8D?7<A>:<268573;@</)?'0*(,,,280457AEB>%%'24/)&%,10)',((),0$18((0=9>>9410$),*&'*%3-65.)/()3?<654*)$'%($+1==>>5FC89:3E5<234283<.42;@=>BB0,34;9;<J?B1./'1.10()(/-1;?@?=:E@A++9262,%.%&().//4).-*&(.-%)#%($-13230)$$&',*++0*$$)(')%*37*7&*-;==BEB:=22210+:30.*)7:;;3>86H2(2?B:D%*//-%$$%')+0%*)',.**)))21::ECBB;=1142.,/8AD;=7883%%&-/3==EDA5C.;+($%#$%(;8;?B'/<99:<:9>ANKD??QEDAA?>CAE@EB:1@<=?C@?1557610)51.08=9<3..67-36&)'1.82?..6>9;C7('0.-'%))%$%$*'74.$*470/*-'(&/6<*624'+.1=:/0-97:<CIFH::>KHBCI4:4;AGHHFC=A@B<9,=?>C/;<?ED//0()*+.65332',3749<*=:;41-//7;?JB9.)%%)&%*(&42->2;BA>@AG;@:CE:>@@A'ADB?B>8+&855;EB@2/152689;<..)&$%%'*$%,,.+622.4$%&&)()'#$(%%+,&)*0,-)(,$++0@5=0/2=$,)&$)$356;=5;6'')34/($.1%%.=@EF@BA@..8/3'&?54/0'''&*0-$$#$(=@<DAB=<>BAND<7?=O;?@;A8C<@<>>@>=<A>BC=7A>EG65-$$$@E:@>67@?959??;?BBC884?76>DERG65B=><1=<289@<@EEA))/4=0001/-*,*+'(&)&003*(&&$%%$(,()$).64<=1+8''0648HGDB@;78-'%#)$%#"%%$&)68718+,8?AC5;3<;.(??>235A??-1',**')411(0:<?>6=HA:;D,''7//0/662=DC;FDFHB<6850+*$'349?>@=?>8;;:9>>:682(><:FBA<=?@>D@=>>CBM@552?3=1120.&#%4:793021('$###%%$#$'%'%&%1%075/*03,3:BBGDIHDGB1;7E4@6@<0-**720',97.&*%->>963?48/*=6C?A8(1A@E@?F%,<-/-804>IGG6<38KHD<78,0.:05523GG7;A-31$&#(('%*<>EHAC?8??IJ><:9<<.*1$44FD:7;1/224$51??B,-/(/0,;3693.$'&'*),++,)*'&,:=DDH@D@*/122)+()%14(-3AE/1,11'1B?762,1<>@;54.&9&&6+,:96$'%%-,%%/&&1-)8(78A=.?>*%6'))$+))'*.0()+8;=C9CED@A<97;;7)?@/+%&'$,-9:>G>264@/*1:6:.0=C@E?;::;%:;798:;3+/34<@>?>9:0.)'(,-)'('##',,35.))+&1/&'2..''641(5'...1*&%#$%%&&',/66(-.*28=>.:E/274;<>BDC:45?>GCD?+;$-@;:<=587<9>5<A9=2<:H7A,+73;;<@:)*)5(,4&/-78CDC6:?4<./,-10*%%%%$$,%%4:'8'3>@BJFA85,=59:8)(1>@??EGE>5+&/+((*-,2*>?*/&&222.17666>:742&977A@D;18::>AA<@4LB71<3@<=@:/46)-55425>=@9EH?GC=EIA:BBBB@@99CFC@F@A:((45:1>4<;?A-/,0,--*,**$$+$%+*4;=B>CDCA@72A;??'//1@7J?CCC>C-$797;A>:;9@AAB7-B&+A82>3021;62C499A<@>B@<9-(/6.,):77=932$%%''%+$%))$+%>+//%144451&'..522%%%
@7c814fd1-508d-4ad1-98c2-097a856dad9a
CGCGCAGTGTACTTCGTTCGGTTACGTATTGCTACGCGCACTCTCTGTTCAATAAAGCAGCGTCAGATGTGTATAAGAGACAGGTTCATTTATCTCACCTCCCAGCCATTTCCAACTGAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAGATATATCTTTCTTTTCATCTAATTCGTTTATCACACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCCTTATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAGTTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTTCATAGTCCTATATCTAAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCTATAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTGTTATTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTTCCGTTCTGTGCACCACTAACCTTAATCATTAAAACATTCCCCTTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTGGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAGCTTTACTTTTAGAGCTGCTGGAGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAGTTGTTTTTCGGATATTACATTAAAGTGTTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACATAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATACATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACAGAAAAAACCACTTGGGGAGGTGGTTTGATCGAAGGTTAAGTCAGTTGGGGAACTGTAACCAGGTAACTGTCTTGTGCGAGACGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTACTTTATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCAGACCGAGATACCTACAGCGTGGCGTATGAAGCGCCACACTTTCTGAGGGCAAGGGTGCAGAAATATCAGTAAATGGGTAGAGAGGCGAACTAGGGACACGGGAGGAGCTCGGTTTACCTAAATCTTACCAGTCTATCAGGGTTCACGCCACCTCAGCGAGCGTCCGATTTTGTGATGCTCGTCGGGGGCGGAGCTATGGAAAAACGCCTGCGGCGCTGAAGCCACTCCGATTGCTGCTTTTTGCTCACATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTTGAGTGAGCTGACACCGCTCGCTGCAGTCGAACGACCGAGCGTAGCAGTCAGTGAGCGAGGAAGCAAACACTATATGTGACATTTTTCTCCTTACGCTCTGTTGTGCCGTTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTGTTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCAGGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACTGGCAGCCTGTTCGTCAGCATCAGGTGCGTCCAGTTTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCATTACCACTTTTCATTTGTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGTGCCATTTTGTCGGTAATTCAGGCTTGCTGACAGACAGGATGTTCTGAATTGTTACGCACCGCCACATCCACCGCTATTACAATTGCCCTGGTCAGGGCTTTGCCCGACACCGCATGTCAGATGCGGAGCCGTGTTTGCTGACAAAACGAAGTGGAAGTAATACGCGCAGGCAGGCTATCCAGTCGCCCTGTTCGTCTGACGGCGAAGAAGACCAGGGAAATCAAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCGGTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCGGAGGTGCTGATCGCTATTACGGAGTATCACCGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAAGAAAACTGTCGAAAACAGACGGTATAGACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATGGCCTATGCAGCTGTCTCTTATACACACATCTCAGCCCACGAGACCAGAG
+
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
@2ace01b4-c39e-4c59-8e0c-80b0972a7814
ATTTGATGAAAAAAAGAAAAAGATATATCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAACCTACAATGCAATTTAACATGGATGATTTTCTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAAT
+
EIG@>87658JG9/((59F1*.96598889?.;8;;>@?+*&)8?H99;<<BB+<;>:==>:;><74$%+$%33><;AD>EFE9?9;E@65KHQ),/2C42:7A=694429<@>?46*7&13).>D@9:/'
@cc1db555-a9ea-4585-acbb-2346cf88e42e
AATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCGCACATATTGCATCATGGCTGTAATGTTGTTGTAAATGTTGATTATTATTGGTTTTTTACTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAGCTAAGATTGAGCTAATGAAAGACAGCACTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCTATCTAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTTAGTATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTATTTATGTTTCTTGATGTGGTTAATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTTATTTTATAGTAATCAATTCTTCTAGAGTTCTTTTTCCGTTCTGTGTTTCACTAACGCGTAGTAAGCTTTGTTCCCTTTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGGGGTGTTTGATAATATTGACTCAGCATTGAGGACACATGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTATGGACATTTCTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAATGAGTTTCTTTATTTAAAGAAGTCTTCATTTCACAAGAAGCTTTTCACTTTTAACAGAGCTGCTGGGTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTTCCCAAAGTTGTTTTTTCGGATATTACATTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCAGAAACACTTGGAAATTTTAAGTGGATATCTTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATG
+
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
@a3804e93-6f81-4c49-8217-c80ef00ec343
GGTATGCTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGGTCTCGTTTGTGCGTGGGCTCCTTCGTGTTGTACAAGAACAGCGGGTCTTGCATGTACAGATGTATCTTTTCTTTTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTATTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCCTTATCTTGCTTTGATTACTGAGTAATGAATTCATTTTTCATCTACATCAATGAGAATAATTGAGTCTTTTGAGACTAAGATTGAGCTAATGAAAGACAACGCTCTGCTTACTCTTCACCAAGCATTGATATTTCATTTCAAATTCATAGTCCCTATATCTAAAATCTCTTTGTTTTTGATCTGTTTGCTATTATTTCAATATCGTTAATTCTATTCCAATAAATTCTTTTCCCAGGTTTGCCTATTATTTCATCTTTTCTTTTGTGTTGAAGTAGTTTTGATGCGTTTTTATCGTTGCTTCTTTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTATTGTTATTTTTATAGTAATCAATTAACTTTCTGGAGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCTTTTCCCTGAGAGCCGAGGGTTTGTCACGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGAGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAAGATGCTTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGTCTAATATCGATGTTTTTAAAGTTGTTTTTCGGATATTACATTAAGTGTTTTAGTTGTTTGAGTTATGCTCTCGAAACATAAAATTTTTAAGTGGATATCTTTTATCGTATTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAGTAATATTACTTTATAGTCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTATTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAGCCACCTGGGGAGGTGGTTTGATCGAAGAAGGATTAGAATCAGTTAAAGAACTGCTTAACCAGGTAACTGTCTTGTGCAGGCAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAGAATTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCGGTGGCGCTTTGTCGTCATCTTACAATTGGACTCCAGACGATAGTTACCGGATAAGGCGCAATCGGAGCTGAACAGGGGGTTCGTGCACACAGCCCAGCTTAGAACAGTTTTATTATTGCACCTTATTTGCCGTAACGCAGCTACGCAGACCGAGATACCTACAGCGTGAGCTGTGAAAGCGCCACGCTTCCGGGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCTGGGAGTCCGGAACAGAGCGCCTGGGGAACTGGAAACACCTGGTATCTTTACTCAGTCTATCGGGTTTCGCCACCTGTGGCTTGAGCGTCGATTTACTGTGATGCTCGTCAGGGCGGAGCCTGTGGAAAAACGCCTGCGGCGCTGGCTTCCTCCGGTGCTTTGCTTTTGCTCATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGGTGAGCTGACACCGCTCGCCGCAGTCGAACGACCGAGCGTAGCGAGTCAGTGAAACCAGGAAGCGGAAGAGCGCCTTATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCTGTCCTGAGCGTTATCTCTCTATGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATAGCAGCCTGTTCGTCAGCATCGGGTGCGTCCAGTTTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTCTCCGTTCTGTCTGTCATCTGCGTTGATTATACATCATGATACCGCTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGGCATTTCTGTCCAGACAACACTGTCACTGCAAAAAGAGAACTGCCGTGCAGCTGTCAGTAATTCAGGCTTGCTGACAGGACAGGATGTGCAATTGTTACCGCGCATACATACGCTATTACAATTGCCCTGGTCAAGGGCTTTGCCCCGACACCCATGTCAGATACACAGACCATATTTTGCCGATAAACAGTGAAGATAATACGCTACCAGGCGTTTATCAAATCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAAGAAAAAAGGGCTGCTGCTAGTGCAGCAAGACCGTTTCACCGGTTATTTGGGCGGCAGCTCTCGGTAAGAAAGTTGCTCACTGACTGATGATCGGGTACTGAAAGAAAGTTATGAGACTGGGGCGTTAGAAAAAACTCTTTATCGACAGCAAGCGGCGTGTCGGGGACAGAGTATACGGGATTGCTGAGTCGCTATTACGGAGTATCACCGTGCCCTGTTATCAGACTTATGGCAGATTCATATAGCTTGGAGAGGGAAAACTGTCAAGCAGACAATTTATGTTTACCATAGCTCCCAAAGTGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCTGACGCATCCTTCCCTGTTTTCCCGGGGTAAAACATCTCTTTTTTACGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTACCTATATCTAAACACCTCTTTCTTACACGCGTGAGCAATAAGTTAGATCTTCTATTGCTTTTCATTACTTGTTTTTCCTGGCACTTGATAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGTTCAATCAGCATCGATGATTAAGAATATACTCTTTTCATTTAAAAGACTCTATGCTTTCTAATCTCTAAGGGTTTGTTTAGTTTTGTCTTTCCATTTATTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTCTCAGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTGATTGCATTGCTGTAGGTTTTGAGATTCCTTGTCTCTTCCCAGTCTATGTCTGTCTCTTATACACATCTCCAGGCCACGAGACCAGAG
+
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
@89720e16-01b9-4595-a6ec-14a5bf8e1e8f
TTTTCTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTGTGTGGTTTTGCTGCTTCTATCAAAGCGATTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTCTATCTCATCAATGAGAATAATTGAGTCTTTTGAACTAAGATTGAGCTAATGAAAGAC
+
GID@9?<ID@6/3-@2CFHE97B?2-38..*/34636++=><,:346?7:?7.FF4GJ0>ADA::A?2:)),.41(=<HFQK?DH?;=:799:>@AA=2+%)+44/?1A298GGCDCRJD@@?:9888>@?95='+8:=?<DG<??A2.BDE=//@6G7666:>>F>@OFLFCEG><<D-<<<:6FCA232*)6,7:?
@11aaf51c-0c29-473a-8995-36778d27c149
GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAGACAGTCTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTCTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTTTCTAGCACTCCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAAGGTTTGCCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTGATACGTTTTTATCGTTGGCTTGCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTTAGTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACGTTCCCCTTTTCCCTGAGAGCCGGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTGAGGGACACGCTTGATTCACTTTGTGTTATCTATCGTTGAGTATTTTGTGTTACTTCTGACCTCTCATCTCCTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAACTATCCCAAAATGAGTTTTCTTTATTTAAAAGTGCTTCATTTCTAAGCTTTTTACTTTTAACAATTTCTGGGTTTTTACGTCATAAAATAGAAAATATCGCGTCTAATATCGATGTTTTTAAATTGTTTCAGGATACACTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTTATAGTAATAATGTGTTTATTTATGCATCACTATACCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCCAGTTTGTCGGAGCTTCTTCTTGTAATTATTGTGTGTTCTGGTCGTAATCTCTAAACTGAAAACGAAAAAACCACCTGGGAGGTGGTTTGATCGAAGGTTAAGTCAGTTGAGACTAGCAACCGGGTAACTGTCTTGTGCAGACGAGTCACCAAAACTGTCGCTTTCAGTGTAGCTGGTCAGGCCATCACTTCAGAGTGTTCTTTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGACAAGGCGCAGCGGTCCGGGCTGAACCAGGGTTCGTGCACACAGTAACGGAGCGAACGACCTACACCGAACTCAATACCTACAGCGTGAGCTGAAAGCGCCACGCTTGAAGGGAGAAGGCGGACAGGTGGCGGTAAGCGGCAGGGTCAGTTTCGGGAGAGCGCACGGGGAGCTTCCGGGGAAACACCTGAGTATCTTTATAGTCCTGTCGGGTTTCGCCACACCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCAGGGGCGAACCTATGGAAAAACGCCTGCGGCGCTGGCTCCCTCCGGTGCTTTGCTTTTTGCTCATGTTCTTTCGACTTTATCCCCGATTCTGTGGATAACCGTACCGCTTTTGGTGAGCTGACACCGCTCGCCGCGGTCGAACGACCGAGCGTAGCCAGGTCAGTGAGCGAGGAAGCGGAAGAGCTTCCTATGTGACATTTCTCACTACGCTCTGTTTGTTGCGTTTCGAAGCATCCTGTCCTGAGCGTTATCTCTCTAATGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGGTTCTTCTGCGAGTTCGTGCAGCACTTCTCACACATGGCAGCCTGTTCGTCAGCATCAGATCAGTTTTTCGAGCAGCGTCAGGCTCTGACGCACGCCAGATGCCCGCCATGTGTGAGGAAGCTGCACGGAAGAAGAACTCCAGAACAGCATCAGACACGCTTTGAAGTAGAAAATGGCACACAGAGGAGATAGCGCTCGGACAGACCAGCCCCTCTGGCTGGCTTTATGAAAATGTGCTCTTCCACTCTCACTCACTATTCATACATGGAGTTCTATATTTTTTTTTCCATCGAAGCTGCGATGTGCTTTC
+
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
@284b6374-10ec-4083-b484-7d3523ebddc0
CGGTAGCCACTTCGTTCAGTTACGTATTGCTGCGCGCGCCTCTCTGGTCGTGGGCTCGGAGGTGTGTGTATAAGAGACAGTATTACATCATGGCTGTGTGTTATTTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCCTTATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTTGAACTAAGATTAGGGCTAATGGAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCATAGTCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCACTTTTGAAGTTTTGAATTCATATAGCTTACCTTTTTTTTAGTTTGTTTTATTTCTCCGTTTTATTTCTTGTGCTTTTTTATTATTATTTTTATAGTAATCAATTCTTCTGGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCACATTAAAACATTCCCTTTCCTGAGAGCCAGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGGGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGGAGTTTTCTTTATTTAAAGGAGATGCATCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTTCCGGATATTACATTAAGTGTTTGGTTGTTTGAGTTATGTCGAAACATAAAATTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGGAAACGAAAAAACCACCTGGGGAGGTGGTTTGATCGAAGGGTTAAGTCAGTTGGGGAACTGCTTAACCGGAGTAACTGTCTTGTGCGAGACGAGTCACCAAAACTGTCCTTTCAGTCATGGCTGTGGTCAGACCATCTTCAAGTACTCTCTTGAACCTCTCGCACGCCACGACTTTTTTACCAATGGCTGCTGCCAGTGGCGCTTCACGCCGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGGTTCGTGCACTGGCCCAGCTTGGAGCGAACGACTGCCGAACCGAGATACCTACAGCGTGAGCTATGAAAGCGCCACGCTTCCCGAAGGAAAGGCGGACCGAGGTATCCGGTAAGCGGCAGAATCGGAACAGGAGAGCGCACGTGGGAGCTTCAGGAAACACCTGGTATCACTATAGTCCTGTCCGGGTTTCGCCACCTCTGGCGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGCGGAACCTATGGAAAAACGCCTGCGGCGCTGGCTTCCCTCCGGTGCTTTGCTTTTGCTCAATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGGTGAGCTGACACCGCTCGCCGCAGTCAGACGACCGAGCGTAGCGAGTCAGAGTGAGCGAAGGAAGCGAAAATACTGCCATGTGACATTTTTCTCCTTACGCTCTGTTGTGCCGTTCAGCATCCTGTCCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCGGGTGCGTCCAGTTTTCGGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGAGTACGGCTTTTTTTTCTTGTTCATCTTTCGTTTTCTCCGTTCTGTCTGTCTGCGTTGTGTGATTATATACGTAATACCACTTTCGACTGTTTTGCTGCCGTTATTTCCGCCGCTTGGCAGCACGGCCAGACATTTCTGTCGAAACAACACTGTCACTGCCAAAAGAAAACTGCCGTGCCTTTGTCGGTAATTCAGAGCTTGCTGACGGGACAGGATGTGCAATTGTTAGCTACGCGCATACATGCACGCTATTACGATTGCCCTGGTCAGGGCTTTGCCCAGACACCCATGTCAGATACGGAGCCATGTTTTATGACAAAACAGAAGTGGAAGTAATACGCGCAGGCAACTATCCAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTTACGGGCGGCAGCTCTCGGTAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGAGTATGCGGAGGTGCTGATCGCTATTACGAATCACCGTGCCTATTATCAGACTTATGGCAGATTGGCTTCCCCGGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCGTGTGCGCAGCGTAAAGCGAGCTGAAAACGATCTGACGCATCCTTCCTGTTTTTCCCGGGGTAAAACATCTCTTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCGTACAATTGCAGCATTATGTTAAAATTTTATAATTGTCTTTAGTCATTTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTTGTTCTTCGCATTGATATACCTATTCTCCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCAATAATCCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAG
+
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
@f38d07dd-ed27-4da3-828d-553899713b62
CATTGTACTTCGTTCAGTTACGTATTGCTGCGCATATACTCTCTGTCGTCGGCAGCGTCAGATGTATAAGAGACAGCATGTGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGATAATAATTCATTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAACGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTACGTCCTATATCTAAAAAATCTACTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTGAGTTGCCTATTATTTCATCTTTTCTTTTTTTTGTGTTAGTATAGTTTGATACGTTTTTATCGTTATTTATTTGTTCTATTAACATGATGATTATTATTCTTGCAGTTTTGATTCATACTAGCTTACCTTTTTAGTTTGTTTTATTTCTCGTTTATTTCTTGTGCTTTTATTGTTATTTTATAGTAATCAATTCTTCTAGGGGAGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCTTTTCCTGAGAAGCCGAGGTTTGTCGCAATGTGGAGGTGTTTGATAATATTGACTCAACATTGAGGGACACGCTTGATTCACTTTGTGTGTTATCTATTCGTTACAGGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTTGGATGTGTCCATGTTATAAAAATAACTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTCCCCAAAGTTGTTTTTCCGGATATTACATTAAGTGTTTTTGGTTGTTTGAGAGTTATGCTCTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTCTTTCATAGTCCTGTTTGGATTGATTTTAACCAGCTTGTCGGAGTTTCTTCTTGTGATTATTATTGTTCTGATTATTAATCTCCTAAACTGAAAACGAAAAAACCACCTGGGGAAGGTGGTTTGATCGAAGGTTAAGTCAGTTGGGGAACTTTGCTTAACAGGTAACTGTCTTGGTAGGGAAACGAGTCACCAAAACTGTCCTTTCAGTGTAGCTGGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTGCAGGTTGGACTCAGACGATGTAGTTACCGGATGGGCTGGCGGTCCCGAAAGACTGAACAGGGGTTCGATTGCACACAGCCAGCTTGGAGCGAACGACCTACACCGAACCAACCAGATACCTACAGCGTGGCAAAGGCTGTAAGCGCCACGCTTCCGAAGGAAGGCGGACAGATATCGGTAAGCGGCGGAGTCGGAACAGGAGGCGCGTGAGAGCTTCCAGGAAGCACACTGTTGTCTTTATAGTCCTGTCGGTTTGCACCTCTGGCTTGAGCGTCGATTTTGTGATGCTAATTCGGGGGCGGAACCTGTATATGGAAAAGCACCCTTGCGGCGCGCTACGAAACACCTCACGGTCGCTTTAGCTTTTTGCTCACATGTTTCTTTCCGACTTTATCCCCCGATTCTGGATAACCATGTTATTACCCGCTTTTGGGTGAGCTGACACCGCTCGCCGCAGTCCAGGCGACCGGGCGTAGCGAGTCGGTGAGCGAGGAAGCGGAAGGAAGCGGCCTTATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCCTGCGCGGTAGGTTCTTCTGCGAGTTCGTGCGGCTTCTCACACATGGCAACCTGTTATTCAGCATCGGGTGCGTCAGTTTTCGAAACAGCGTCAGGCTCCCTGACTTTTTATGAATCCCGCCATGTTGAGAATTTACGGCTTGCTACTGCTTGTTCATCTTTTCGTTTTCTCATTCATCTGTCATCTGCGTTTGTGCAGTTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTGACGGAGCATTTCTGACCAGACAACACTGTCACTGCCAAAAAAGAAAACTGCCGTTTATGACCTGACCAGTAATTCAGGCTTGCTGACAGGACAGGATGTTGCAATTGTTATACCGCGCATACATACGCTATTACAATTGCCTGGTCTAGCAGGGCTTTGCCCCATTTACCCATGTCGGATGCAGACCATGTTTTGCTGACAAAACAGAGTGGAGTAATACGCTGTCTCTTATACACATCTCCGAACCCACGAGACCAGAGAGTGCGCGCAGCAATGCGTAACT
+
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
@9ba6ff2e-b66e-4042-ba35-56bd15d38273
AAATATTTGATTATTCCAGTGGTTTTTGCTGCTTCTAGCAAAGCGTTGTCATAATAACGATTACTGAAGTAATAATTCCATTTTCTATCTCATCAATGAGGCATAGTGAAGTCTTTTGAACTGGGTTGAGCTAATGCGGCGCTCTGCTCGCCAAGCTGTTTCATTTAGTCGCAGTCATATCTAAAGGAAATCTCTTTTGTTTTGATCTGTTATATTACAATATCGACCAATTCGTATCACAGGTTACCTATTATTTCATCTTTCTTTTGTGGGTGTAGTTTTATTGCATTTTTATCAGGCTGCTTTCACCTATTTATGTTTCTTGATATTACTGATTTTGAAGATTCATATAACGCACCGGATTTGTTTTATTCTCCGTTTATTTCTTGTGCTTTTGTGTTGATACATATTGTCAATTCTTCTGAAGGAAATTCTGCACCGTTCCCACTTTGAGCCGAGAAGTTTATTGACTGTGTACGCACGATTCACTTTTTGTGTGTTATCAGCTCGTTGGTGTCTATGTTACTATTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTATAAAAATAGCTATCCCAAAATAGTTTTCTTATTTAAAAGAGATGCTTCATTTCAAAGCTTTGCACAACAGAGCTTTGCTGGGTTTTTTATCGCCAAAATGAAAATGTCTATCGATGTTTTAAGCGAATGGCAAGTGTTTTAGTTGAGATTGCTCTCGAAAACGCAAAATTTCTTAAGTGAATATCTTTTATCATGTTGCTTGCTCTCCCATTCCACGTTATAGTAATAATGTGTTATTATAAATCTTATGCCGCTATTTCTAGAAATGTGTATAGTCCTGTTTGGATTGATTTAACCGGTTTG
+
570''+--1-0.%%($&&&3+.59<96*)+$$$%$,'&%(*&%**(*$&,%%#%&&'+6.'+++-.&&*%)),+/+.68446=-3+'%+,/514))),'')'1,2)45/,1&%%&**10/(-&)&#$**/.*01,,5'-6-,)#+$%+3$%')*&%&$&(+3124/1*66+*&%$(%...6.44/&(.0123:8788923.((++00,+++$'&%(%'&&32-.''',,--,*%&%')'++42%(#&$)'&(*+/;9678447/1466'0))&.(')&&-,,$$$#%$&,.-)(((($#$($$%(-%$$$(%&'&'&&.19/-,00+&#$%%'&$(+..'&%%$',/)--/))*%%'&,$+$./-'/0.-)(.%'%*=C>0::<8+@A753,,033$%&(%%#%%)103.2*/4+-+26974-2%$&&&&#$*$$##$%')+*$%'&&'')/,/')#%%&%%$)-55541((-$0007.($2:9:48*++,..1+*)/-),($-+$*.7551#$'%$&)+..))+,(%$'/5123**.**,)-177,-)+635?777*#%)(&2+%%''(&()'34462/0,,45:;<8//,-/,23787004332/23)')''0)*.26;8565&'('(',04--,+&'.,,,233591//(,440/+(%#')&&'*-2632359=0//.%-.3'(2278;,%%$'&#&.))%,,1:::990(%$$*%*'()%',()-&&%&$#$%-.))%)-*++(*),/)10855876-..-33,34''')&%,&0133122'+-376,(+,.-0110132.1+(##%(****$##('&%**$(,(./2.,.'..&%%(*'1*&#/./14454$+$8,,$*+,#$$*%*33/%
@80757ee1-b38e-49c9-a1fe-9f8c14abf831
GTTGTACTTCGTTCGGTTACGTATTGCTGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTATTATAAAGTGAGTTGAGCTAATGAAGAGACAGCGCTCTGCTTCTCCTTCACCAAACATTGATGTTCATTTAATTAAACCCAGTCCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTGAATTGTATCTAATCTTTTAGGTTGCCTATTATTTCATCTTTATTTTGTGTTAGTAGTTTTTGATACGTTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTGTGCATGCTTTTTGCTTTATTTTTATAGTAATCAATTCTTCTGGGGAGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTTCCTGAGAACCGAGGTTTGTCGCAATGGAGAGTGTTTGATAATATTGACTCAACATTGGGGACACTTGATTCACTTTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAGAAGTGCTTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCCCGATGTTTTCCCAAAGTTGTTTTCGGATATTGTTAAGTGTTTTTGGTTGTTTGAGAGTTATGCTCTCGAAACACTTAAAATTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTTAATTTACATAGTAATAATGTGTTTATTTATGCATCACTATACCACTGTTTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCAGGTTTCTTCTTGTGATTATTGTGTTCTGGTCATTAATCTCTAAACTGAAACAGAAAAAACACCTGGGGTGGACAGTCGAAGGATTAAGTCAGTTGAGAACTGCTTAGCCAGGTAACGTCTTGTGCGAGACGAGTCTTAAAACTGTCCTTTCCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTACCCCTGCCCGGTGGCGCTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCAGTCCGGGCTGAACGGGGGGTTCATTGCACACAGCCCAGCTTAGACGAACGACTACACCGAACCGAGATACCTACAGCGTGAGCTATGAAAGCGCCACGCTTCCCGAAGGGAAGAAGGCGGACAGGTATCCGGTAAGCGGCAGAGTCGGAACAGGAGAGCGCACGAGGGAGCTTCAGGGGGAAACACCTGGTATCTTTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCGGGGGAGCGGAGCCTATGGAAACGCCTGCGGCGCGCTGACTTCCTCCGGTGCTTTTGCTTTTGCTCACATGTTCTTTCCGACTTTATCCCCGATTCCACCATGGATAACCGTAATTACCGCTTTTGGGTGAGCTGACACCGCTCGCCGCAGTCGAACGACCGAGCGTAGCGAGTCAGTGAGCGAGGAGCGGAAGAGCGCCTTATGTGACATTTTCTCCACTTACGCTCTGTTGTGCCGTTCCGGCATCCTGTCCTGAGCGATTATCTCTCTGTGCTATTTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCGGCTTCTCACACATGGCAACCTGTTCGTCAGCATCAGGTGCGTCCAGTTTTCGAGCAGCGTCGGAAGTGACTTTTTATAGATCCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCGCACCCCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTTGACGGGCATTTCTGTCAGGTGGAGCAACACTGTCACTGCAAAAAACTGCCGTGCGGTTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATATTCTGGTGTTATACCGCGCATACATGCGCTATTACAATTGCCCACCAATCGAGCTTGCCCCGACACCCATGTCAGATACGGAGCCATGTTTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCGGGCTATCCCAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAGAAAAGGGCTGCCAGATGCGGCAAGACCGTTTCGGTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGAGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCAGGGGACAGGGAGTATGCGGAGGTGCCAGTCGCTATTACGGAGTATCACCGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCGTTGTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTTTTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCCAGTGCGTACAATTACAGCGATATGTTAAAATTTTATAATTGTCTTTAGTCATTTGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTATCTCACTAAACAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAAAGCGTAATCGGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATAGTTAGATCTTCTATTGCGCCATTCTTGTTTTTTCTAGCATGATAAAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTAGCCAAGGCTTGGTGATGAAATGTTAATCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAGAATATACTTTCTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTTAGTTTTGTCTTTCATTTATTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAGCTTGAAAATGACTTTTTTATAATCATTTATTTTTCTCAGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTATCTCTTCCCAGTCTTATATAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGTGGCTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTCTGTCTCTTATACACGGCCCTGACGCTGCCGACGACAGAGTGCGCGCAGCAGTACGTAAC
+
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
@ef1c09bf-a870-4994-85e6-196592dd4143
GTTGTACTTCGTTCGGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCAACGGCGTCAGATATTATTATAAGAGACAGCTCCTTCACCAAGCATTGATATTTCATTTAATTCGCCAGTCCTATATAAAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTACCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTTATCGTTGCTTCTTCATTTATGTTTCTTGATGTGGTTATTATCGCTTGCGGTTTTGAATTCATATAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTTAAAACATTTCCCCCCTTTCCTGAGAGCCGAGGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGGGGGACACGCTTGATTCTGTCTCTTATATACAATCTCCGAGCCCACGAGACCAGAGTGCGCGCAGCAATGCGTAACT
+
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
author	iuc
date	Fri, 16 Oct 2020 17:04:35 +0000
parents	84dcccebad3d
children