# HG changeset patch # User iuc # Date 1598943998 14400 # Node ID 148f328604455480548b9e73b1d137204d1d68be # Parent ce2bf68a260d9e275a1be6a6db887b828416d03c "planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/medaka commit e80b649094384fc6d7a8f917300db3550cc99a44" diff -r ce2bf68a260d -r 148f32860445 annotateVCF.py --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/annotateVCF.py Tue Sep 01 03:06:38 2020 -0400 @@ -0,0 +1,398 @@ +#!/usr/bin/env python3 + +# Takes in VCF file and a samtools mpileup output file +# Fills in annotation for the VCF file including AF, DP +# SB, and DP4 +# +# Usage statement: +# python annotateVCF.py in_vcf.vcf in_mpileup.txt out_vcf.vcf +# +# Can generate in_mileup.txt with samtools mpileup (and can restrict which sites to generate pileups for with in_vcf.vcf) + +# 08/24/2020 - Nathan P. Roach, natproach@gmail.com + +import sys +from math import isnan, log10 + +from scipy.stats import fisher_exact + + +def pval_to_phredqual(pval): + return int(round(-10. * log10(pval))) + + +def parseSimpleSNPpileup(fields, ref_base, alt_base): + base_to_idx = { + 'A': 0, + 'a': 0, + 'T': 1, + 't': 1, + 'C': 2, + 'c': 2, + 'G': 3, + 'g': 3 + } + + base_to_idx_stranded = { + 'A': 0, + 'T': 1, + 'C': 2, + 'G': 3, + 'a': 4, + 't': 5, + 'c': 6, + 'g': 7 + } + ref_base2 = fields[2] + counts = [0, 0, 0, 0] + stranded_counts = [0, 0, 0, 0, 0, 0, 0, 0] + ref_idx = base_to_idx[fields[2]] + dp = int(fields[3]) + carrot_flag = False + ins_flag = False + ins_str = "" + ins_len = 0 + insertion = "" + del_flag = False + del_str = "" + del_len = 0 + deletion = "" + # dollar_flag = False + for base in fields[4]: + if carrot_flag: + carrot_flag = False + continue + if ins_len > 0: + insertion += base + ins_len -= 1 + continue + if del_len > 0: + deletion += base + del_len -= 1 + continue + if ins_flag: + if base.isdigit(): + ins_str += base + else: + ins_len = int(ins_str) - 1 + insertion = base + ins_flag = False + elif del_flag: + if base.isdigit(): + del_str += base + else: + del_len = int(del_str) - 1 + deletion = base + del_flag = False + else: + if base == '^': + carrot_flag = True + continue + elif base == '$': + continue + elif base == '+': + ins_flag = True + elif base == '-': + del_flag = True + elif base == '.': + counts[ref_idx] += 1 + stranded_counts[base_to_idx_stranded[ref_base2]] += 1 + elif base == ',': + counts[ref_idx] += 1 + stranded_counts[base_to_idx_stranded[ref_base2.lower()]] += 1 + elif base == 'N' or base == 'n': + continue + elif base == '*': + continue + else: + counts[base_to_idx[base]] += 1 + stranded_counts[base_to_idx_stranded[base]] += 1 + af = float(counts[base_to_idx[alt_base]]) / float(sum(counts)) + if float(sum(stranded_counts[0:4])) == 0: + faf = float("nan") + else: + faf = float(stranded_counts[base_to_idx_stranded[alt_base]]) / float(sum(stranded_counts[0:4])) + if float(sum(stranded_counts[4:])) == 0: + raf = float("nan") + else: + raf = float(stranded_counts[base_to_idx_stranded[alt_base.lower()]]) / float(sum(stranded_counts[4:])) + dp4 = [stranded_counts[base_to_idx_stranded[ref_base]], + stranded_counts[base_to_idx_stranded[ref_base.lower()]], + stranded_counts[base_to_idx_stranded[alt_base]], + stranded_counts[base_to_idx_stranded[alt_base.lower()]]] + return (dp, af, faf, raf, dp4) + + +def parseIndelPileup(fields, ref_base, alt_base): + counts = [0, 0, 0, 0, 0, 0, 0, 0, 0] # indel ref match, indel fwd ref match, indel rev ref match, indel alt match, indel fwd alt match, indel rev alt match, other, other fwd, other rev + ref_base2 = fields[2] + + carrot_flag = False + ins_flag = False + ins_str = "" + ins_len = 0 + del_flag = False + del_str = "" + del_len = 0 + first_iter = True + forward_flag = False + last_seq = "" + last_seq_code = 'b' + for base in fields[4]: + if ins_flag: + if base.isdigit(): + ins_str += base + else: + ins_len = int(ins_str) + ins_flag = False + if del_flag: + if base.isdigit(): + del_str += base + else: + del_len = int(del_str) + del_flag = False + if ins_len > 0: + last_seq += base + last_seq_code = 'i' + ins_len -= 1 + continue + if del_len > 0: + last_seq += base + last_seq_code = 'd' + del_len -= 1 + continue + if carrot_flag: + carrot_flag = False + continue + if base == '.' or base == ','\ + or base == 'A' or base == 'a'\ + or base == 'C' or base == 'c'\ + or base == 'G' or base == 'g'\ + or base == 'T' or base == 't'\ + or base == 'N' or base == 'n'\ + or base == '>' or base == '<'\ + or base == '*' or base == '#': + if first_iter: + first_iter = False + else: + if last_seq_code == 'i': + if last_seq.upper() == alt_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + elif last_seq_code == 'd': + if last_seq.upper() == ref_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + elif last_seq_code == 'b': + if last_seq.upper() == ref_base.upper(): + counts[0] += 1 + if forward_flag: + counts[1] += 1 + else: + counts[2] += 1 + elif last_seq.upper() == alt_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + if base == '.': + last_seq = ref_base2 + forward_flag = True + last_seq_code = 'b' + elif base == ',': + last_seq = ref_base2 + forward_flag = False + last_seq_code = 'b' + elif base == '>' or base == '<' or base == '*' or base == '#': + continue + else: + forward_flag = base.isupper() + last_seq = base.upper() + last_seq_code = 'b' + elif base == '+': + ins_flag = True + ins_str = "" + elif base == '-': + del_flag = True + del_str = "" + elif base == '^': + carrot_flag = True + elif base == '$': + continue + if first_iter: + first_iter = False + + if last_seq_code == 'i': + if last_seq.upper() == alt_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + elif last_seq_code == 'd': + if last_seq.upper() == ref_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + elif last_seq_code == 'b': + if last_seq.upper() == ref_base.upper(): + counts[0] += 1 + if forward_flag: + counts[1] += 1 + else: + counts[2] += 1 + elif last_seq.upper() == alt_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + dp = int(fields[3]) + af = float(counts[3]) / float(sum([counts[0], counts[3], counts[6]])) + if sum([counts[1], counts[4], counts[7]]) == 0: + faf = float("nan") + else: + faf = float(counts[4]) / float(sum([counts[1], counts[4], counts[7]])) + if sum([counts[2], counts[5], counts[8]]) == 0: + raf = float("nan") + else: + raf = float(counts[5]) / float(sum([counts[2], counts[5], counts[8]])) + dp4 = [counts[1], counts[2], counts[4], counts[5]] + return (dp, af, faf, raf, dp4) + + +def annotateVCF(in_vcf_filepath, in_mpileup_filepath, out_vcf_filepath): + in_vcf = open(in_vcf_filepath, 'r') + in_mpileup = open(in_mpileup_filepath, 'r') + out_vcf = open(out_vcf_filepath, 'w') + + # First pass parsing of input vcf, output headerlines + new headerlines, add VCF sites we care about to to_examine (limits memory usage for sites that don't need annotation) + to_examine = {} + for line in in_vcf: + if line[0:2] == "##": + out_vcf.write(line) + elif line[0] == "#": + out_vcf.write("##annotateVCFVersion=0.1\n") + out_vcf.write("##INFO=\n") + out_vcf.write("##INFO=\n") + out_vcf.write("##INFO=\n") + out_vcf.write("##INFO=\n") + out_vcf.write("##INFO=\n") + out_vcf.write("##INFO=\n") + out_vcf.write(line) + else: + fields = line.strip().split() + if fields[0] in to_examine: + to_examine[fields[0]][int(fields[1])] = (fields[3], fields[4]) + else: + to_examine[fields[0]] = {int(fields[1]): (fields[3], fields[4])} + in_vcf.close() + data = {} + + # Populate data dictionary, which relates chromosome and position to the following: + # depth of coverage + # allele frequency + # forward strand allele frequency + # reverse strand allele frequency + # dp4 - depth of coverage of ref allele fwd strand, DOC of ref allele rev strand, DOC of alt allele fwd strand, DOC of alt allele rev strand + for line in in_mpileup: + fields = line.strip().split() + if fields[0] not in to_examine: + continue + if int(fields[1]) not in to_examine[fields[0]]: + continue + (ref_base, alt_base) = to_examine[fields[0]][int(fields[1])] + if len(ref_base.split(',')) > 1: # Can't handle multiple ref alleles + continue + if len(alt_base.split(',')) > 1: # Can't handle multiple alt alleles + continue + if len(ref_base) > 1 or len(alt_base) > 1: + if len(ref_base) > 1 and len(alt_base) > 1: # Can't handle complex indels + continue + data[(fields[0], int(fields[1]))] = parseIndelPileup(fields, ref_base, alt_base) + if len(ref_base) == 1 and len(alt_base) == 1: + data[(fields[0], int(fields[1]))] = parseSimpleSNPpileup(fields, ref_base, alt_base) + in_mpileup.close() + # Reopen vcf, this time, skip header, annotate all the sites for which there is an entry in data dictionary + # (Sites without entries have either multiple ref or alt bases, or have complex indels. Not supported (for now), and not reported as a result) + in_vcf = open(in_vcf_filepath, 'r') + for line in in_vcf: + if line[0] == '#': + continue + fields = line.strip().split('\t') + if (fields[0], int(fields[1])) not in data: + continue + (dp, af, faf, raf, dp4) = data[(fields[0], int(fields[1]))] + dp2x2 = [[dp4[0], dp4[1]], [dp4[2], dp4[3]]] + _, p_val = fisher_exact(dp2x2) + sb = pval_to_phredqual(p_val) + if fields[7] == "": + info = [] + else: + info = fields[7].split(';') + info.append("DP=%d" % (dp)) + info.append("AF=%.6f" % (af)) + if isnan(faf): + info.append("FAF=NaN") + else: + info.append("FAF=%.6f" % (faf)) + if isnan(raf): + info.append("RAF=NaN") + else: + info.append("RAF=%.6f" % (raf)) + info.append("SB=%d" % (sb)) + info.append("DP4=%s" % (','.join([str(x) for x in dp4]))) + new_info = ';'.join(info) + fields[7] = new_info + out_vcf.write("%s\n" % ("\t".join(fields))) + in_vcf.close() + out_vcf.close() + + +if __name__ == "__main__": + annotateVCF(sys.argv[1], sys.argv[2], sys.argv[3]) diff -r ce2bf68a260d -r 148f32860445 macros.xml --- a/macros.xml Thu Jun 18 05:08:40 2020 -0400 +++ b/macros.xml Tue Sep 01 03:06:38 2020 -0400 @@ -5,6 +5,7 @@ medaka + scipy diff -r ce2bf68a260d -r 148f32860445 medaka_variant.xml --- a/medaka_variant.xml Thu Jun 18 05:08:40 2020 -0400 +++ b/medaka_variant.xml Tue Sep 01 03:06:38 2020 -0400 @@ -1,4 +1,4 @@ - + via neural networks macros.xml @@ -32,7 +32,7 @@ -i alignment.bam -f reference.fa -|& tee '$out_log' +2>&1 | tee '$out_log' ]]> diff -r ce2bf68a260d -r 148f32860445 test-data/annotate_vcf_test.pileup --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/annotate_vcf_test.pileup Tue Sep 01 03:06:38 2020 -0400 @@ -0,0 +1,3 @@ +NC_045512.2 45 G 31 CCCCACCCCCCccccccccc,ccCCC*,+3ttccCC ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ +NC_045512.2 685 A 75 .-9AAGTCATTT,-9aagtcattt,-9aagtcattt*.-9AAGTCATTT*G.-9AAGTCATTT.-9AAGTCATTT,-9aagtcattt*,-9aagtcattt,-9aagtcattt,-9aagtcattt,-9aagtcattt,,-9aagtcattt,-9aagtcattt,-9aagtcatttG.-9AAGTCATTT*,-9aagtcatttG.-9AAGTCATTT.-9AAGTCATTTG.-9AAGTCATTTG.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT*.-9AAGTCATTT*.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTTG.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT*,-9aagtcattt,-9aagtcattt*,-9aagtcattt,-9aagtcattt,-9aagtcattt,-9aagtcattt,-9aagtcattt,-9aagtcattt*,-4aagt,-9aagtcattt,-9aagtcattt**G,-9aagtcattt,-9aagtcattt,-9aagtcatttG,-9aagtcattt,-9aagtcattt*,-9aagtcattt* ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ +NC_045512.2 1813 T 51 ..-3AAA..-2AA..-1A*.-1A.-3AAA*..-1A..-1A.-2AA.-1A.-3AAA.-2AA.-2AA.-3AAA.,-1a,-1a,-6aaaaaa,,,-1a,,-2aa,-2aa,,-1a,-1a,*,-1a,-1a,+1a,-2aa,-1a,+1a,-1a,,-2aa.-3AAA,-1a.-2AA,-1a*,-2aa,-2aa ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ diff -r ce2bf68a260d -r 148f32860445 test-data/annotate_vcf_test.vcf --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/annotate_vcf_test.vcf Tue Sep 01 03:06:38 2020 -0400 @@ -0,0 +1,9 @@ +##fileformat=VCFv4.1 +##medaka_version=1.0.3 +##contig= +##FORMAT= +##FORMAT= +#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT SAMPLE +NC_045512.2 45 . G C 46.359 PASS GT:GQ 1:46 +NC_045512.2 685 . AAAGTCATTT A 260.487 PASS GT:GQ 1:260 +NC_045512.2 1813 . TA T 11.034 PASS GT:GQ 1:11 diff -r ce2bf68a260d -r 148f32860445 test-data/annotated.vcf --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/annotated.vcf Tue Sep 01 03:06:38 2020 -0400 @@ -0,0 +1,16 @@ +##fileformat=VCFv4.1 +##medaka_version=1.0.3 +##contig= +##FORMAT= +##FORMAT= +##annotateVCFVersion=0.1 +##INFO= +##INFO= +##INFO= +##INFO= +##INFO= +##INFO= +#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT SAMPLE +NC_045512.2 45 . G C 46.359 PASS DP=31;AF=0.900000;FAF=0.937500;RAF=0.857143;SB=6;DP4=0,2,15,12 GT:GQ 1:46 +NC_045512.2 685 . AAAGTCATTT A 260.487 PASS DP=75;AF=0.880000;FAF=0.789474;RAF=0.972973;SB=0;DP4=0,0,30,36 GT:GQ 1:260 +NC_045512.2 1813 . TA T 11.034 PASS DP=51;AF=0.607843;FAF=0.521739;RAF=0.678571;SB=0;DP4=0,0,12,19 GT:GQ 1:11 diff -r ce2bf68a260d -r 148f32860445 test-data/basecalls.fastq --- a/test-data/basecalls.fastq Thu Jun 18 05:08:40 2020 -0400 +++ b/test-data/basecalls.fastq Tue Sep 01 03:06:38 2020 -0400 @@ -498,519 +498,3 @@ GTTGTACTTCGTTCGGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCAACGGCGTCAGATATTATTATAAGAGACAGCTCCTTCACCAAGCATTGATATTTCATTTAATTCGCCAGTCCTATATAAAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTACCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTTATCGTTGCTTCTTCATTTATGTTTCTTGATGTGGTTATTATCGCTTGCGGTTTTGAATTCATATAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTTAAAACATTTCCCCCCTTTCCTGAGAGCCGAGGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGGGGGACACGCTTGATTCTGTCTCTTATATACAATCTCCGAGCCCACGAGACCAGAGTGCGCGCAGCAATGCGTAACT + 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-GTTGTACTTCGTTCAGTTACGTTGCTGCGCGCACTCTCTGGTCTCGTGGAAGCCAGAGATGTGTATAAAGACAGACGATTGAGTTGCACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTTGTGTTATCTGACCTTTCATCTCTTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAATATCATCGTCCTAATATCGATGTTTTCCCAAAGGTTGTTTTTCGGATATTACATTGTTAAGTGTTTTTAGTTGTTTGAGAGTTGTACTCTCGAAACACTTAAAATTTTTAAGTGGATATCTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAATATTATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGTTCTGGTCAATAATCTCCTAAACTGAAAGCAGAAAAACCACCTGGGGAGGTGGTTTGATCGAAGGTTAAGTCAGTTGGGAACTTCAACCAGGTAACTGTCTTGTGCGGACGAGTCACGCAAAACTGTCCTTTCAGTGGTGTAGCAGTAGTCAGGCCATCACTTCAATTACTCTCTTGAACCTCTCGCATCGACTTTACCAATATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAAGGCGCAGCGGTCGGGCTGAACGGGGGTTCGTGCACACAACCAGCTTGGAGCGAACGACCTACACCGAACCGAATACCTACAGCGCTGACTATGAAAGCGCCACGCTTCGAAGGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACGGGGAGAGCGCACGGGGAGCTTCCGGAAACACCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTTTGTGATGCTCGTCGGGGCGGAGCCTATGGAAAAACGCCTGCGGCACTGGCTTCCTCCGGTGCTTTGCTTTTTGCTCACATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGAGTGAGCTGACACCGCTCGCCGCAGTCCAGCGACCGAGCGTAGCGAGTCAGTGAAACGAGCGGAAGAGCTTACTGCTATGTGACATTTTCTCCTTACGCTCTGTTATTGCCGTTCGGCATCTGTCCTGAGCGTTATCTCTCTGTACTGTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCAGGTGCGTCCAGTTCGAGCAGCGTCAGGCTCTGACTTTTTATAGATCCGCCATATTTGGATTTGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGAATTTCGTGAACTGTCACTGTAAAAAACTGCCGATGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGGTGTTATACCGCGCATACATGCACGTAATACGTTGCCCTGGTCAGGGCTTTGCCCCGACACCCATGTCAGATGCGGAGCCATGTTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCGAGGCTATCAGTCGCCCTGTTCGTCCTGACTGACAGAGAAGAAGACCAGGAAATCAGAAAGGGCTGCTGAATGAGCAATACGTAAC 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-;;?22%%8@OM@??@><=:EEE9=CB5:1-9)1$#&'%1%'0&(,-&(?==?9)*<:>/'6.''+%&65/+,(,.*/<<85).7@889%(%%$'#('(0+($*''%(&'$2459@-%9$),3'*&%'%*.33/,/&,$($,.$&'().&3*+,2(%&(%9:?=<8=:25:C?'C<;/-/./9-<3<;87;87';454CFAI@++1448$/;93+;<912=,0B??@-43:82,DFE;1>),--,//8B05?DOC-&4(+,8454@??@15##$/1/04++0/@?EE>39&(9((1=BD@=?>=/4//$/1==BBAA@FD>8.*,-57=*,>2,7&&.&&$&'%'$)''$$%223')+(79<63:A7:947*&'&$)$&$)&&2:1+523.2'&&(-)++-8C=@DC>CLCQFFECA0@3<@EDCA9FEE=<<6<:))+))8;;@B9>;?5> -@3903ad0d-208b-48d9-b2eb-010c5552927d -GTTGCTTTGATTAGTTGTATTCTTCTATATCACGCGCGCATGTCTGGCGACTGGAGATGTATAAGAACAGGACGAGCATCACAAAATTGAAATACTCAAATCAGTGGTGGCAGAAACCCGACAGGACTATAAAGATACCAGACGTTTCCCCTGAGTGTATCTTCTCCCTCGTGCGCTCTCCTGTTCCCGCCTTTCGGTTTACCGGTGTCATTCCGCGCAACATGGCCGCGTTTATCTCATTTCCACGCGCCTGGCACTCGGATGAGCAGTTCGCTCCAAGCTGGACTGTATGCGACCCCCCGTTAGTCCGACTACCACGCCAATTTCGGCAACTATCTTCTTGATTCAATCCGAAAAGAGCACGACAACACGCCATTGGCGGTAGCCACTGGTAACTAGATTCACGGAGTGAGATTGCAGAACTTACACAAGAGTTCTTGATAGCAGCCTGACTACGGCTAAACTGAAAAAACAAGTTTTGAGTACGCTCCGTGTAAGCCAATGAGTTACCTGGTTCAACGAGTTCCCCAACTCATTGAACCTTTAGCTCGCCTCCCAGGCGGTTTTTTCATCCCCAATTAGCCGGTAATCCGCGCCAAGAAAACGATTCAGAGATTACAAAACGATAAATGCATCGCACCAATCGTTCAAAAAGCAAAAAACGATCAAAGCTCGCTGACATACAAAAAATTTATATAATCAGGCTTCCGGAATTATCTATTAGCCCGTACAATAATTGGAAATCTGCCTGTTTTTAATACAGTGACAACTACGACCTACAGAGGTATGCGTATGAACGCTATTAATCGACGACTTACAAGTAAGGAGGTGCTAATGAAGAGAAATCGTATATGTTGGCGGTGCCGAAAAGACCTAAAAAATCATTCACAAAAGCCATGTTTGATGAGGTCTTGGTAGAGATAGTCCGCTTACAGTGCGGAATTCAACCTATCAGAAAAATAAAACAATGAACGGCCTCAGAAGGGTCATGGAATGGACAAAAAATGGAAAGCCAGCATACAGACTGGTTATGTAGTAGGAAGAGCATTTTCATACTACACGCTTTCAAAAACATCTGATGGGACCCAAAATCGAAGAGGAAATCAAAAGAACGATATAACAAATATCAAAAATCGTGTAAAAAACAAAAAGGCAAACAGTGGTCACACCACTGCTTTTTACTTTAACATCAATAGGGCTTTCTTTATCTACGGCCGAAAGACACATCATAACAAAACCCCTATTCTGCAAAGCATTTCTAAAGATATCTTTTATTTACAACACAGTGTGTGTTTCATTTGGCTATCTTCTGATAGGTTGAATTCCGCACTGTAAGCGGACTATCTCTACAAGACCTCATAAACATGGCTTTTGTGAATGATTTTTAGGGTCTTTTCAGCACCACCAACTTCTTTCATTAGCACCTCCTTACTTGTGTCGTCATTACACCTACCTCAGCAGAGTCAGCTATAAAGCCTCTGAGTGCTGATATGACCTCTCTCTCCGAGCCCACGAGACACGCGCGCGTAGTAGAGCAATATGGCAAAAAAAAAAAAATCGGTGTGCTTCCGTTCCGGTTACGTATTGCTCACGCTGACGTGTGTTCGTCGGCAGCGTTTGAGATTGGTAACATAAGAGACAGGCTTCGAGGATTTCGTTGGAGTTCAGGGTAAAACCGCGTGGGGTACCTTCGCCAGGTTACGGCCCACGAACTGTTCGCGGACTTCATCGCCCGGGTAAGCCGAACCGATTTCGTGCTTGATACGTTCTGCGGTGGCTTCACCGATCAGGGAGGCGCCGTATTACGACGCATGGTTGATGACGCTTTGTCGAAGCGATCGCCACCAAGCCGCGCGCGGAGAGGAGTAAACCACGCCGTTCAAGGAGATAACAGCAACTTCAGTGGTACCTACCGATATCAACCACCATAGAACCGGTCGCTTCCAGAAACCAGAAGCAGGCCAGCACCAATTGCGGCAGCCATCGGTTCTTCAATCAGGAAGACTTCACCCGGGCACCAGCGCCTGCGCCAGGATTCACGAATTGCGCGGCGTTCAACCTGGGTCGCGCCAACCGGTGTTGCACAAAACCAGAACGCGCGGGCTTGGACGCATAAAGCTGTTGCTGTGCACTTGTTTGATGAAGTGCTGGGCATTTTCAGTCACGAAGAAGTCGGCGATAACGCCGTCATTGGGCGAATGGCGGCAATATTGCCCGGCGTACGGCCAGCATCTGCTTCGCGTCATGACCTACTGCAGCTACGCTTTCGGTGAACCGGCACGATCCTGACGAATGGCCACCTGGAAGGCTCATTCAATGCGATGCCTTGTCCTTTTGCGCTGATGGACATTCGCAGTACCCAGGTCAATGGACAAGTCATTGGAAAAACATACCACAGAAATTTTTCAACATACTAAGGGATAATCCTGAAAGCTGGGGCGGAAAGAAAATCCGCTTACTTTACCAATACACGCAGCAGCAGAGGCGCAAAAATCATCACTACGGTGAAAATTAGATTGCGAGAGTTCGTTTCCCTTTGTTACAATCTGCCTGAGTCCAGAAAGGCTTAATGCATCAACAGCATTCCTCGCCTGTTTGCAACCGCGTGAGTCATTCATCTGCATATGTGTGCAACAATCTGGCGAGCAGACAAGCACACTCCCGTGAGGTCGCAGCGCGCGTTATTCTACGTGAAAACAGATTAAACGGCAGGTTAAACCGAGTATCTTTGGCAGATATTTTTTCACGTTGGTATCAAACGGCTGTGAGGACGCGAAAAAAATCCCCTTGCCCGCACAGCAACACCGCGCTGGATCAGGTCTACCCTCGCTTTAAAGACGCACACCAGTGGCGTAAACTTGGGTGCTGGTCCCGGAGCAGGCTTCCACCAGGCTTTGAGAACCAGCAGCTGGTTCTCCGTTCTTCTCAATGTTTCTGACCAGCGGATGGAGCTTGAGTAACTCAACATTAAGTTGCTTTGATCAACTGGTGCTTACCAGCGTCAAACCAGCCTGGTTGACGGCTACCCCATCACCCCTAAAGCATTCACTAAACGAATAACGGGTTGTAAACGCGACTGATATGTTGACCTACATCGGCCTCTGCAAATTCAATAATTATGCGTTTCGTTGTGATTTTCACATTGCATTAACGTATCGCGCAGCCAACGCTGAAAAACGCAGGCGAATCAGCGACTCAACGGTAACCTGAATCGCCAGATTTTCCCTCCAGCCAGTAACGCAATAGTGAATGAATGGCTGATTTCGAACGGTCATACCTCTTCCCGATAAAATAAACTACCGAGACCATTCGGCATGCTCTCCGCCGAGCTAACCTACTTCATTACCATGAAGATGCGGCACATAGGAGTTCGCGATGTTGAACCTGACCTTCGCGAGTAACCGCCGGTTTTTGATAAAGGCGCGGGCCGCCGCGACTGAGCATTTGCTCTCGATAAGCGTACCAGCGAACGCTACACGTCCTTTTTCAGGCAACGAGTCATCGTAAATAGCCTTCATTGCCGCCCTGCAACGCATTACGCCGTGGCAGACTCTGCATGTTCCATTACCGCAACCGGTATCTGACCGCCGCAGGCGCAGATTTTTGTGTGGATCATATCGTCGCGATCGAGCATTTTATTGTTCGGCAAGGTATCGACGGCTTTGATTAACTGACCGGCGATGCTCTCTCTTTTAACGTCCGGTGCGGTAACAGCGCAGCAAAATCACTGCGGTGGTAACGCGCCAGCAGTGCGCCAGGAGAGTAGCGCATCATAATGTCGGTGGCAGATTCGTCAAGTGAAGAACTGTTGCTTCCCAGCCTGGCTATTTTTAGTATCAGCTCAACATATTGAAATCCGGCAGACGAAAGATCATCATCACGATCCCGTGGGTACCTACTTTCTCCTGATCTTCCAGTAACGTTGCTAACTGATTATCGAAAGAGTCGGTTTATTGAGGCCGGTTTCACACCCTGGGCGGCATAAAACGGATCAGCGTATCAAGACTACAGCCGTGTTGTTCGCGTGCGTTCTGAGCTTCACGAAGCAGCGTATCTAGCGCACTGCTGTGCTGGGCGGCCATTCGCATAGATGGTTCCCAACACGTGAAACCCGCTCACCGTTTAAGATACGATAGCGGTTTCCAGCGTTCTTGCCCGGCAAGTTTGCCGTTAACCAGCGTACCGCCAGAACATAACAATGATAAAGCCAATCGCCCCCGTGAGCGGCGCGGTAGTCATTAAAGAATGGAAATAGTTGCCGCTCGGATCTGATAAAATAGACGCAGCGACATCCCCGGATGCTTTATCAACGGAACACTCAGTTCGCGAAACAGATCGCTGGAGCCAACCGGACGATAACTACCATTTCTGGCCGGGGTATAAACCTGTTTATCACCATGGAGCAGGTCTACACAGATGATATCTGCCGACATCGATATTCGGTAATTTGTGGCCTTAATGTGCTGAAGTCATTCGGCTTCGGTGGGTATCAATCGCCGTGCGCCACCACCTGAACGCGATGGCTAAACTTATACTGAATTGCGTTGGCAAAGCTTAGCGAATAGCCCAGCAAAGTCACAAAAATTGTTCGCCCGGTGAGCAGCGTAACAAAGGCCGAGAACTTCGTCGTTAATCTCATCGCTTGTGTTAACTCCGGTAGCAGTGAGGAAGCGGGCATACTAACTAAATCAGTTTATCTCGCAATTTATTGCGCTTCATCAACTTTGCTTTTCCATTGTAGTATAGTCTTCAGAAATTGTTTTCAATCCATCATGTACATGAGGACCACTTATATACAGGCGTTACTTTTAGAACAGCAGGTTGGCAAAACTCTCGCATCGGTACAGACACTTGACAGAGAGTCCGCTGCCGGAGCGATGTCACGGTTGATGTTCACTGGTCAGGCCTGGACTATAAAGATGCGCTGGCGATTACCGGTAAGGAAAATCGTCGTAATTTTCCGGTAAGTTCTGGGATCGATTTTGCAGGCTTTGTACGCACACCAGCGAAGATCCGCGTTTTCATGCCGGTCAGGAGGTGTTACTCACTGGCTGGGGCGTTGGTGAAAACCACTGGGTGGGCTGGCGGAGCAGGCGCGAGTGAAAATGACTGGCTGGTTGCACCATGCCGCAAAGTGGACGTAAAGCAATGATTATCGGTACTGCCGGTTTACCGCCATGCTGTGTGTGATGGCGCTGGAAGATGCCGGTGTTCGCCCGCAGGACAGGAGATTGTCGTGACGGGTGCCAGTGGTGAAAAATTGGCGGTACGCGTGGCGCTGCTGCATAAGTTGGGTTATCAGGTCGTTGCGTTCCGGAAATTCGCATGCCGAATATCTGAAAGTTTAGGTGCCGGTGTCGTCTCCCTCGTGATGGGGTTTGCCGAATCCGTCCTCTGGAGAAAAACAAGTCTGGCTGGGGCAATTGACACTGTTGGCGACAAAGTGCTGGCAAAAGTGCTGGCGCAAATGAATTACGGCGGCTGCGTGGCGGCCTGTGGTCTGGCGGGTGGTTTACTCTGCCAACCACGGTCATGCCATTTATTCTGCGTAATGTCCGTTTGCAAGGGTGGATTCAGTAGCTGACGCCACCAGGGCGCGCGCACAAACCACAGCGGCGGCGATGCCGATTGCCGGAATCATTCCAACACCCGGGCGGCAAAGAAGAATATCTCTGTCAGAGGCACCGAACTTTGCCGAGGCCATCATTAATAACCAGATCCAGGGTCGCACGCTGTTGAAGGTTAACTAACCGTGACCCCAGCAAGGAATAATAGCAAGAGAACTCATTTTGACATCATTATTCAATCGGTTAACGGGAAAAGCGGTTGGCGGGACAACTCGTCGAACACCTTGGTCAGGAAGTTGTACAACATCATCCAAACTGGAAAGTCATGATTTCGACTGACCACAAATTGGTACGCATTGATACTCCTCTAAACAGCCATTATTGATATGCCTCCGTCGCCTGTTAGGTTTATGGTGCTTTGCCTGAGCGACACTACGCCAACCTGTTACTGATTTCTGGTCCATGGGGTGGATAATCTGATTTTATTTGACTACAAATTAACCACTCCGAACTATTTAATGCTGAGAATTGTCAGTGGTTGATTTTGCGTGCTTTAGCATTCACATCTATCAGACGATGCAGTGAAAATTGGGTAATCCCCAGCAACCACGCTGCGTAGCTGTCGTCTATCTTTGTCGCGATCACAAAAACCCTACATTATTTGTGGTCTGTGAAGATTATCACCATTGCAGCCCCTCATCTTCGCAGGGCTGGCTTTCAGCTTTTTCACCTTACGTTATAAAGTTCCGTCGATGATGGCGCTAATTTCGTGGTGTGCAGCTTGTTGCAAAATACACGGTGTTGAAGGTTATTTACGTAGTAGCTGTTGATTATCTTCCCTGATAAGACCAGTATTTAGCTGCCAATTGCTACGAAATCGTTATAATGTGCGACCTCGTCCTCCTGACGCAGTTTTGCGCTGCGGAAAAGGTGACATTGGCGCAACAGAAGGTATATTTGTTTTTTCGGAGGATAGCAGCAGATCGCTGCACAATGTCCATCAAGTCTAACATTGACCTCTGGGGCAAAATAGACCGGCGTCCCGGCCTGCTGGAATTTATAGCCATGCATACAGCTGTCGGGGCATACGCTTTACAGACGGCGGTGAAACGCCTGTCACAATCACACTAAACAAAGAGTACGGAACCCACTCATGGATATTCGTAAGATTAAAAAACTGATCGAGCTGGTTGAGAAGAATCAGGCATCTCGAACTGGAAATCTCCGAAGGCGAAGGTCGAGTACGCATCAGCCGTGCAGCTCCTGCCACAGAGTTTCCTAATGATGCAACAAGCTTACGCTGCACCAATGATTAAAGCAGCCAGCTCAATCTAACGCAGCCGCTCAGCGGCAGCCGTTCCTTCCAGCAGGCTTCCAGCAGCAGCCGGAAATCGATGGTCACATCGTACGCTCCCCGATGGTTGGTACTCTACCACCGCACCCCAAAGCCCGGACTGTACCAAAAGCGTTCATCGAAGTGGGTCAGAAAGAAGTCAACGTGGGCGATACCCTGTGCATCGTTGAAGCCATGAAAATGATGAACCAGATCGAAGCGGACAAAATCCAGGCAGTGAAAGCAATTCTGGTCGAAAGCGGACAACCGGTAAATTTGACGAGCCGCTGGTCGTCATCGAGTAACAGGCGAACATGCTGGATAAAATTGTTATTGCCAACCGCGCTTGAGATTGCATTGCGTATTCTTCGGCCTATCGTAAAGAACTGGGCATCAAGACTGTCGCTGGCTGCACTCCAGCGGATCGCGATCTAAAACACGTATTACTGGCAGATGAAACGGTCTGTATTGGCCCTGCTCCGTCAGTAAAAGTTATCTGAACATCCCGGCAATCATAAGCGCCGCTGAAATCCTCTGCCGGCGCAGTAGCAATCCGCATCCGGGTTACGGCTTCCTCTCCGAGAACGCCAACTTTGCCAGGCAGGTTACAGACGCTCGGCTTTATCTTCATTGGCCCGAAAGCAGACACTATTCGCCTGATGGGTGACAAAGTGATGTCGGCAATCGCGGCGATGAAAAAGCGAACGTTCCTTGCCGTACCAGGTTCTGACGGCCCGCTGGGCGACGATGGATAAAAACCGTTGCCATTGCTAAACGCATAGGTTATCCGGTGATTATCAAAGCCTCCGGCGGCGGCGGCGGTCGTGGTATGCGTGTAGTGCGCGGCGACGCTGAGCAGCGCAATCCATCTCCATGACCCGTGCGGAAGCGAAGGCCGCATTCAGCCAACGATGCCAGTTTACATGGAGAAATGGAAAATCCTCGCCGCATCGAGATTCAGGTACTGGCAAGTCAGGGCAACATCTATCTGGCGGAACGTGACTGCTCTATGCAGCGTCGTCACCAGAAAGTGGTCGAAGAAGCACCAGCACCGGAATTACACCCGGAACTGCGTCTTCATCCGCGGCGAACGTTGTGCTAAAGCGTGTGTTGATGTCAGCTATCGCGGTGCAGGTACTTTCGAGTTTGTTCGAAAACGGCGAGTTCTATTTCATCAGGAAATGAACACCCGTATTCAGGTAGAACACCCGGTTACAGAAATGATCCACCGGCATTGACCTGATCAAAGAACAGCTGCGTATCGCTGCCGGTCAACCGCGTCGATCAAGCCGCAAGAAGAAGTTCACGTTCGCGGCCATGCGGTGGAATGTCGTATCAGCGCCGAAGATCCGAACACCTTCCTGCCAAGCCCGAGCAAAATCACCCGTTTCCACGCACCTGGCGGTTTTGGAGTGCGTTGGGGTCTCATATCTACGCGGAGCTACACCCGTACCGCCGTACTATACAAACTCAATGATCGGTAAGCTGATTTGCTACGGTGAAAACCGTGACGTGGCGAGTGCTCGCATGAAGAATGCGCTGCAGAATGATCATCGACGGTATCAAAACCAACGTTGATCTGCAGATCCGCATCATGAATGACGAAGAACTTCCAGCATGGTGGCACTAACATCCACTATCTGGAGAAAAGAAACTCGGTCTTCAGGAAAATAAGACTACGAAAGCGTCAAAAGGCCGGATTTTCCGGCCTTTATTACAGGGATCTGGCAACCCCCGCAAGGTACAATCCTCTTTTCTTCACCCATCAGGGACAAAAAATGGACACTCGTTTTGTTCAGGCCCATACAAGAAGGCGCGCTGGGCGCTGGGGCTGACCCTTTTTGTGTTGCTTCTTGGTTTTGGTTAGTAGCCGCTTACTTACCTGGCGGTGCCCCCGGTTTTACCGGCTTTCCGCGCTGAGTTTGAGATGGCCCGCCTGCATCCTGACGCCGCTACTGTTTATTGGACTGTGCTGGGCGATGGTGGGAATTTATCTATCGCGATATCCCACTGGAGGATGATGCAGCTTGAAGTAATTCTACCGCAGGTCGCCTATCTGGTGGTGGTGTTCGGTATCTCTGTTTTATGCACGATGCGTAAACGGAGCACCGGCACCGCTGCTTAATAATTATTTCCTCGGCAGCCGCTCTGTGGGCGGTATTGTGCTGGCGATGACGCTCACCGCGACCTATATCAGTGCCAGTTCTGGTTTATCGGCGGGCCGGGAGCTGCTTATAAATACGGCCTGGGCTGGGTATTGCTGGCGATGATTCGGCTTCTGCAGTCTGGCTTTCACTCGGTATTCTCGGCAAAGAAGTTTGCGATTCTTGCGCGCCGCTACAATGCAGTGACATGAACGATATGCTGTTTGCCCGCTACCAGAGTCGTCTTCTGGTGTGGCTGGCGGGATTGAGTTTGCTGGTTGCGTTCGTTTGGTTGCGATGACCGTGCAGTTTATCGGCGGTGCGCGCCTGCTGGAAATCGCGGCGGGTATTCCTTATGAAACCGGGCTGCTGATTTTGGTATCGGCATTGCGTTATATACCGCCTTTGGTGGCTTTTTTCGCGCCAGCGTGCTGAACGACACCATGCAAGGGCTTGTGATGCTGATTGGCACCGTTGTTGCTGCTTATTGGCGTGGTACATGCCGCTGGCGGCTTAAGCAACGCAGTACAGACCTTGCAAACCACCGAATACCACTGCAACTGGTTACGCCACAGGCGCTGAAAGGCGATATTCTGTCGCCTGCCTTTATGACGTGATTCTGGGTACTGGTGTGCTTTGGCGTGATTGGCCTGCCGCATACTGCGGTGCGCTGTATCTCTTATAAAGACAACAAAGCAGTACACCGGGGATATCATCGGTACGATTAGCAGTCATAATCCTGATGTTCGGTATGCACCTGGCCGGAGCGGTGGGTGGTGGTGATCCCCGATCTCACCGTACCGGATCTGGTGATCCCGACGTTTAATGGTAAAAGTGCTGCCACCTTTTGCTGCCGGGATCTTTTTCTGGCTGCACCTATATGGCTGCGATCATGTCGATAATTAACCCCAACTGCTGCAAAGTTCCGCTACGATCATTAAAGATCTCTATCTCGTCCGGATCAAATGCAAAACAGAGACGCGTCTGAAGCGGATGTCGGCGGTAATTACGTTGGTTCTCGGCGCGTTGCTGCTTGCCGCCTGGAAGCCGCCGAAATGATCATCTGGCTGATTGCTAGCCTTCGGTGGGCTGGAAACCGTTTTCCTGGCTGGCCGCTGGTGCTGGGTCTTCCACTGGGAACGCGCAACGCCCAAAGCGCGCTAAGTGCGATGATCCGTTGGCAGCGTGCTGTATGCCGTACTCGCGACGCTGAATATTTCAATTACCTGGGCTTCCACCTATTATTGCCCTCGTTACTACTAAGTTTTCGGCTTTCCTGGTCCACGGAAACCGTTTCGGTACATCCGTCCCGCAAACTACCGTTTTGACTACTGATAAATAAGAAATTTTGCCATTGCCTTGGATCAACTGAAACTGAACACCGGCGCAGACGCGGAAAGTCTTAGCGATGCGCTGGTGGAAGCGGTGCCGTTTCTATCACTTTTTCCGGGATACCCACGATACGCCAGTATTTGGGCCGCTGCCGGGCGAAACGCGCCTGTGGGGCGACACCGATGTGATTGGTCTGTTCGACGCTGGAAACCGATATGAACGACGTGGTGGCGATTCTGGAAAACCATCGCTGCTCGGCGCAGGCTTCGCCTCGAACAACTAGAAGATAAAGACTGGGAAGCGCGAATGGATGGATAATTTCCACCGATGCGCTTTGGTGAACGACTGTGGATCTGCCCTAGCTGGCGTGATGTGCCGGACGAAAACGCCGTCAACGTGATGTTAGATCCAGGGCTGGCGGCGTTTTCAGTACAATTACCCTGATCCAACCACCTCTGTGCCTGCAATGGCTCGACCAGCCTCGATTTAACCGGTAAAACAGTCATCGACTTGGCTGTGGTTCCGGCATTCTGGCGATCGCAGCGCTGAAACTGGGTGCAACAAAAGCCATTGGTATTGATATCGATCACCAGGCGATTCAGGCCAGCCGCGACAGCACCAGACAATGGCGTTTTCTGACCGTCTGGAACTCTACTTACCGAAAGATCAGCCAGAAGAAGTAGCCGACGTGGTGGTCGCTAACATCCTTACAGGCCCATTACGTGAACTGCTTCCTGTCTCTTTTATACACATCTGACGCTGCCGACGAACAC -+ 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-GTTTATACTTCGTTCAATTACGTATTGCTGCCACTTGCTATATACGTGTCTTCGTCAGCAGCGTCAGATGTGTATAAGAGACAGCTCAAAGGCTATTATTAATACGGTTATCCACAGAATCAAGGATAACGCCGGAAAGAACATGTGAGCAAAAGCCAAAGCACCGGAACAAACCAGCGCCGTTGCCGTTTTTTTCCATAGGCTCCGCCCCTGGCGAGCATCACCAAAATCGACGCGCTCAAGTCGGAAATTGGCGAAACCGATAGGACTACTCTAAAGATACAAGCGTTTCCCCTGGAGGCTCCCTCGTGCGCTCTCCTGTTCAAGGCCCTTGCCCAGCACCCCAGATACCGCATCGCCTTTCTCGCTTCCCGGAAGCGTAGCTCTCATAGCTCACGCTGTTGGTATCTCCAGTTCGGTGTGGGTCGTTCGCTCCAAGCTGGGCGGTGTGCACGAACCCCGTTCAGCCCGACCGCTGCGCCTTGTCCGAAGTAACTATCGTCTTGGAGTCAACCCGGAAAGACACGACTTAACGCCACTGGCAGCATGCATTGGTAACTGATTTAGAGGAGTTGAGTCTTGAGTTATGCACCTGATAAGGCTAAACTGAAAGAACAAGTTTTTGGCGACTGTGCTCCTCAAGGCCAGTTACCTCCAGTTCAAAGGCGCCAGCTCTATGGACAGCTGAAGAGCCGCCCGCCAGAGGCGGTTTTCCAGGGTTCATGGGGATGGCGCTCTTTGAACCGGGCTGAAAAGCGCATCGCAAAACTGTTCTTTTCAGTTGCTTATCGGGTGCGCCCCTCGAGACTCAACTTCCTCCCCCAAATCAGTTACCAATGGCTGCTGCCAGTAACAAAATCGTATCTTTCGGTTAGTAGTTACCGGATAAGGCTTACGGCTGTCCTACGCTGGGCTGAAAATTCGTACAGCCAGCGGAGCGAACGACCTACGCCGGAACTGGTATGAGAGCGCCGCGTATTCGAGGAGAAGGCGGACATGAGTATCGATGAAGCCGGGATCAGATGAGAGAGCGCGCGCGAATTTCCAGGAAATTTGT 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-GATGTGCTTCGTTCAGTTACGTATTGCGCTAGAGGCTCACTCTCTGTCCTCGTCGGCAGCGTCAGATGTGTAATATAAGAGACAGAAAAATTCTCTTCTTTTCAAGATGCTTTGGTTTGGGCAGAAAGCTAATCCTAGCAAAACGATAATAAGATCTCAGACGGTGTGGGGTTTATTGAAAAATGAAAAGAGTGGATTCACTCAACAAAACAACGATGCATTTTTTGGACAACACCACTGTCTATATACGTACTCATATGTTTCACAGTGTCGTATATTTGAGTCTATGTTACGTACGTTACAGGAGCCTATTTTGACTGGTTACAGGCATTCTTGCAGCAGCTTACAGAAACCCTAGCTGTAATCCAAAGTGACTACCAGGGCTAGACGAACTTTATCCCCCACAAAACCCGCTTTTTAAACGGATCTTCTTGAGATCATTCATGGAGAATCGTAATCTCTTAGCATACAAACGAAAAAAACCGCCCAGCAAGGCAGTTTTTCGAAAGTTCTCCAAAGGCAGCAACTCTTTGAACCAGGGTAACTATTGGAGGAGCACAGTCACCAAAACTTGTCCTTTCAGTTTAGCCTTAACCGGCGCATAGCTTCCAAGACTAACTCCTCTAAATCAGTTACCAGTGGCTGCTGCCAGTGGCGTTTTGTCGTATCTTTGGGGTTGGACTCAAGTCGATAGTTACCAGCGGATAAGACGCAGCGGTCAGACTGAACAGGGGTTCGTGCATACAGTCCGAAAAAGCAGGAGCGAACTGCCTACCGGAACTAGCGAGTGTCAGGCGTGGAGATTAGATAAACGGCCATAACAGCGGAATGACACCGGTAAACCGAAGGCGGGAACAGGAGAGCGCACGAGGGAGCTACCAGGGGAAACGCCTGGGATCTTTATAGTCCTGTCGGGTTTCGCCACCACTGATTAGGCAATCAGATTTCGTGATGCTTGTCAGAGGCAGACCTATGGAAAACGGCAACGCCGCATCCTTTCCTTCCTTTGCAGTTATTCCGCTTAGTCTTTATCCAGCCATTCGTAAGTAGCAACGCCTGCAGTCACGCTTAGGAGCACAGCGACCCGGGTGGGACTGCGGCGAAACACGAAATGGCGCTGGATAAAGAGACAAGCAGAAATCAATCGAAAGAGCAAGGAAAGGATTGCCTTTGACGAAGCATCACGAAATCTCACAGAAGACACGCACATCGTCAGCGGCGTCAGATGTGTATAAGAGACAGAGCTGAACGGAGTGATTTCGCGCAGCAGGATGGAGTTGGTCAGGCGATTGCAGCGAAGACACTTTGAACGCTTCCACGTAGTCAAGCGTTGCCGGATCTTTACCTGATCACGATGTTCTACTCAACCGCCCAGAAAGTTACAAACGCCAGCACTTCCGGTCTGAGCAAAGTTAGACAGCAGTTTCGGTGATGATCAGAGAAGCGGGTTATGGGTGATAGCCGGGGCGATGAAATCCGCACGGTACCATTTGGTTCCTGTGGATCAGCTGGTAGAACGCGTGCTGACCGTTAGTGCCTGGTTCACCCCGGATAATCGGGCCAGTCTAGTAATTCGACGTTACCGTTACAGTCAACGTACTTACCGTTGGACTCCATATTGCCCTGCTAGAGTACGCCGCGAAACGGGCCATATACTGGTCATACGGCGGAATCGCTTCAGTTTCGCGCCAAAGAAATTGTTGTACTGGATGCAATCAGCGCCAGTAAATCACGGGCAGGTTTTTCTCGGCAGGCGTGGTGGAGAAATGCTTGTCCATCGCGTGTGCGCCAGAGAAGCAGTTCAACGAAGTTATCGCAGAAAGCCGATGGAGAGAACAATCCGACAGGCCAATCATGACCATAAAGGTAACGACCACCGACCCAGTCCCCGGAGACTCGGGCATGTTGGCGGTATCAATGCAAACTCGCCAACGGCTTTGGCGTTGGTTAGGAAGCGCGCCGCAAAGTGATGTTTCGCAACGTGTTTTGCATCACCAGCCGCTTTCAGAACCAGTCACGCGCACTATGGGCGTTGGTCATGGTTTCCTGAGTGGTGAAGGTTTTAGATGCTACCAGAGTTGGCAATGGTTTCGGGTTTACTTTTTTCAGCACTTCCGCGATGTGAGTCCATCGACGTTAGAAAGTGCATGTTCAGGTGATTTTTGTACGGACGCAGTGCTTCAGCCAGTCTTTATGCCCATGGAGCCGAGTCAGAACCGCCGATCGATGTTCACTACGTCAGTGATTGCTTTGCCAGTACTTATAACCCTTCCACTCACCGGAAATAATCGCTTGCGAAGGTTTCATCTTCTCCAGCCCGCGTTGACTTCCAGCATAACGTCTTACACCCATCAAGCAGAATCCAGGGTATTGCTACGGACACGCAGCGCTACGTGCAGCACGGCGCAGTTTTCGGTGCAGTTGATCTTCTCACCAGAGAGAACATCGACTTAATCGCGCCCACTGAATCCGCACTCTTTCATAGATCTTATGAGTTCGCCAGCGTCTCTTCAGTGATGCGGTTTGGGTAATCCACCAGCATCTGATCGTCGAAGGTTGCGGAGAACTTAGAAAAACAGTCGCCGTCTTTAGCAAAGATCGGCGATCGTAACGTCTTTCATTTCAACTCAGGAAGTGTTTCTGTAGTACCTGCCAGGCAGCGGTCTGCGTTGGATTGATGTTTTTCATTAGCAATACTCTTCTGATTTTGAAATTGTGACTGGAAGATTAGCGCCAGTCACAGAAAAATGTGATGGTTTAGTACCGTTAGCGTAATGTGGCCGAGTAAACTAACAGCGCAGTGAAGCATTTATTAGCTGAACTACTGACCGCCAAGTGGATGAAAAATCCGCATGACCCCATCGTTGACAACCGCCCCGCTCACCTTTATTTATAAATGTACTACCTGCATGGCGCAGGCCAGAAGAGCGCGTTGCCCAAGTAACGAAGTGTTGGAGGAGCCAGTCCTGTGATAACACCTGAGGGGAGTGCATCGCCGAGGTGATTGAACGGCTGGCCACGGATGGCATCACATCGGCTACAGAGGCTGAATCCCTGATTGTCACCAAGCGTTCGCAGTCAGGCGTTTCGCAAGTGGTAAGACACTTCTGGGTGAAAATAGTAGCGAAGTATCGCTCTGCGCCCACCCGTCTTCCGCTCTTCCCTTGTGCAAGGCTGAAAATGGATCCCTGACACGAGGTAGTTATGTCTGGAAATTGTTGTCTCCAAGTTGGCGGGTACCAGCGTAGCTGATTTGACGCCATGAACCGCAGCGCTGATATTGTGCTTTCTGATTGATGCCAACGTGCGTTTAAGTAGTCGTCCTCTCGGCTTCTGCTGGTATCACTAATCTGCTGGTCGCTTTGGCGGAAGGCTGGAACCTGGCGAGCGATTGAAAAACTCTGACGCTATTCGCAGCATCCGGTTTGCCATTCTGGAACGTCACCGTTACCCGAACGTTATCCGTGAAGAGATTGAACGTCTGCTGAGAACATTACTGTTCTGGCAGAAGCGGCGGCGCTGGCAACGTCTCCGGCGCTGACGGATGAGCTGGTCAGCCACGGCGAGCTGATGATGCTCGACCCTGCTGTTGCTGTCGAAATCCTGCACTGAACGCAGTATTTCAGAGCACAGTGGTTTGATGTACGTAAAGTGATGCGTACCAACGACCGATTTGGTCGTACAGAGCCAGATCTTAGCCGCGCTGGCGAACTGGCCGCGCTGCGGCTATCACGCCTCAATGACGGCGAAGTGATCACCCAGGGATTTATCGGTAGCGAAAATAAAGGTCGTACAACGACCTTGTGGGTGGAGGCAACAGTTATACGGCAGCCTTGCTGGCGGAAGCTTCACCGCATCTCGTGTTGATATCTGGACCGACGTCCCGGGCATCTACACACCACCGATCCACGCGTAGTTTCCGCAGCAAAACGCATTGATAAATCGCGTTTTTACCGAAGCGGCAGAGATGGCAACTTTTAGTGCTGCAAAAGTACTGCATCCGGCAACGTTACGCTACCGCAGTACACGCAGCGATATCCCGGTCTTTGTCGGCTCCGGCAAAGACCGCGCAGGTGGTACGCTGGTGTGCAATAAAACTGAAAATCCGCCGCTGTTCCGCGCTGGCGCTAAATCGCAATCAGACTCTGCTCACTTTGCACAGCCTGAATATACTGCATTCTCGCCTTCCTCGCGGAAGTTTTCGGCATCTCGCGCGGCGTAATATTTCGGTAGACTTAATCACCACGTCAGAAGTAGGCGTGGCATTAACAACCGCCAGTACCACCGGTTCAACCTCCACTGGCGATACGTTGCTGACGCAATCTGCTGATGGAGCTTTCCGCACTGTACCGGGTGGAAGTAGAAGAAGGTCTGGCGCTGGTCGCGTTGAGTTGGCAATGGCTTCTGTCAAAAGCCTGCAGCGTTGGCAAAGAAGGTGTCAGCGTACTGAACCGTTCAACATTCGCATGATTTATTTACGGCGCATCCAGCCATAACCTGTGCTTCCTGGTGCCCGGCGAAGATGCGAGCAGGTGGTGCAAAAACTGCATAGTAATTTGTTGAGTAAATACTGTATGGCCTGGAAGCTATATTTCGGAGCCGTATTGATTTTTGCTTGTCACTATACTCATCAATAAACGAACCTGTACTCTGTTAACCAACATCTTTATCGGAGAATAATTGCCTTTAATTTCTTACATCTCTACGTAAATGCAAATGAAGAGATAATAAGTTAGGCAGGCAAGTGCAGCTCTATAATTGTCTATGAGCAGATTCCCGTACACACTGAACTCTCTGGCTCACTGGGGGCACCAGCGCTCCCCGTATTACCCAAAAGAGATGACTGAACGCGAGCAGCGTGAACTTAAAACACTGCTGGATCGGGCGCGGATTGCGCATGGTCGCTGTACTGACCAACTCCGAAACCAACAGCATTGAAAAAGATACATCGATAAAGTGGTCAGGCGTGAGGCTGAAGCAAAAAAAAAGCCCGCCAGTTAAAGAAAAAGCAGGCTTATAAACCAGCGGATCCACCAGAAGCGTCATTTAGCTGGTCAGCAAATGCGTCGACGCGCGGCAGGCGCAGTTAGCGCCCCTTCTTTTACGCCCGGCGAAGTCAAAAGCCTTACCGTTTGGACGCCGGGCGACCGCCTTTTTCCGCCCGTTTTCCATCATGTGGCACGACTGGACGTTTAATACCTACAGTTTTTCGGTTTGGCCTTCGCTTTAGGTTTTGCCTCGGAAGAGGAATTTTCAATGAGCTTAAAGAGGTCGATTAACTCATCACGTCAGTTAAATCACGCCATTCCCCAGCGGGAATGCCGCTTAAACTAACGTTCATGATGCGCGTACGTTCCAGCTTTTTCACTTCGTAACAAAGTGCTCGCACATGCGACGGATCTGACGGTTCCAGCCCCTGCACCGGGGTAATGCGGAAGACAAACTAACGCTTCTTTTTTGGCTTTACACTTTTTCGTCACCGTCCGAGGATCGCCTCCCGCCCCATACCACGAATGATTCATCGGTAATCAGTTTATCGACCGTCACCAGATACTCTTTCTCATGATCGTTACCGCGGAGGATCTTATTCACCAGATCGCTGTGATTGGTGAGGAAAATCAGCCTAAGTCTTTATCAGGCGGCCAATCAGGAACACGCGTTGCTGTGGTTAACGAAATCGACAATGTTATCGCGCTCGCCATCTTCGGTGGTGCTGACAATACCGACGGAGGCTTGTTCAGGGCGATAAGTACCAAATCTTCGGCTTCAGGCTCAATCCAGCTGACCACGTTTACTTTCCACAACGTCGCCGGAGTTTCACCTGATCGCCAATGGTGGCTCACTCGCCATTAAGGAACACATTGCCTTTACTCGATATAGCGATCCGCTTCGCGGCGTAGAGCAAGATTCCGCTTTCGCTGATACATTTGGCCCAAACGAGGCTGATGAGTCAGGCAGCATAAATTCTCCTGTAAAACGCGGAATATACCGTACCTCTTGGCAGGAAAAACAGGGTTATGCAGCAACGTCAAGAATTAAATGTGATCTGCCACGCCTTTTATCACAAAGTGTCTCCGGAAGTACGATGCAAATTTGCCTGGCAAAATAAGGATGATCAACATATTACGAACCACTGCACACCTTGCTACTGATGGCTACTACTGAAGGCTTCGATGTGCAGAAAGCGCTATTTCTCCCCCCATGCAAAGAGTGAAAAATCGGCACGAAGGCCATCATGATGGGGTTATATCAGATCAAGCCAGGTGAGAAAGCGTGTACACAAATGTACAGGAGAACCAGGAAGGCAGCAATGCAAACAGTGACGATATCCGTTTGGTTGTGAAGATTGCCCAGCTCTATTACGAACAGGATATGACGCGGGTGCCGTCGCGCGAACTGGAGTATTTACCGCACCACCATCAGCCGCTTGCTTAAACGAGGCCATGATCAGGGAATTGTCACCATCACCATCAACTACAACGAAATCTCTCTGACACCGACAGCAACTAAACAAAAAGTTTGGCCTGAAAGACGTTGTGGTGGTGTCAGGAAATGATGAGGATGAAGAGACTCAACTGGCGATGATGGGGTTACACGGCGCGCAACTGCTGGATCGCTTGCTGGAGCCTGGCGATGTCAGTTTTCCTGGGGTCAGCGCGGTGAGCGTGGTTTAAAAAGCTTTGCATTACCTGCCACCAGGCGAAGCAATCGCGGCAGTTAATCTGCGTACCAATTATTGGCGGACCGTCCAGCTGATAAACTCGAAAGCCGCTATCACGTAAACACATTAACCTACAGCGCGGCAGCAAGCCTGCCAAGAAGGGAATCGCATCTCTCGCAGATTTTCCGGCTCTGCTGGATAACCCCTTAATTCGTAATGGGATCATGCAGTCTCAGCGCTTTAAAACCATCTCTGCCTGGGATAATCTGGATGTCGCCCTGGTGAATTGGCTCACACCAGCCATTCGCGACAGCGCTAACGGCATGCGTTTTTATGATGGTGAAGAGAGTGACGACCTGAATGCCCGCCAGGTTGCGCTAACCCGATATTTGCTCGCACTTTTTTGATATTCGGCGCAATGGATTTGAAACGAATATGAGCGAAAAAAACACTCTCTATCGAAATGAATAAATTGAATTAAAGCAGGCACGATATTCCATTGGCATTGCCATGAGTGAAGAAAATACAGCAGGATTGTTGAATTTGCACTGCGTGAAAATATATTAATTGTCTGAGGTAACGAATAGCAGCACAGCTGAACTATTATGAAATAAAAATCTTCCCGATGTTTGTAATAAAAATTACGGCGGGTCCCTATTATCTAAAAACAGGAGTCTATTATGCAAACGTGGTTAAATTTGCAGGATAAATCATTATCGTCACCGGCGGCGCATCAGTATAGGTCTGGCGATTGGCAGAATTAATAGCACAAGGCGCGAATGTACAGATGGTCGATATTCACGGTGGCGATGGACAATATGAAGGTCATAAAGGCTATCAGTTTGGCCGACCGATATTTCCAGCGCGCCAAAGAGGTAAATCATACGGGACGAAGCGCGAGAAATATCTTCAAGCGTGCAGCCGTGAGCGATTATATACGATTGTTTTCCGAGGTCATTTACGCGTCATACTAAATAAATACAAGTAAGTGCGGAAGCGTATAAGAAAAAAGCATTACATTAGAAAAGTATGCGTGAATATAAAAGCCAGAAGCGTTATTACAGCATTTGCTTTTATGATGATGATAAATCTTTGCGACGGCGCGATGCGATCACGGCGCTACATGGAAATGTTTGGGAATGGAACTGGGCTCAGAAGCAATATGATGTGGAGCGGGTGTTTTTGATCTAATATGGTGATAACCTTTCTTTTTAAAAGATGGAAAAAACAGACATACCTTTTTCGCAGAATATATGAAAAGCTTTAATGACGTGCATGACCTACCATCAGAAGTGATGAAACAAATGGTGCAGGAGTGCAGATATGACGCGGAAACGACGAGAATAAATATTATTTGCGTGATACCTTTTTGCCATGCACTTTGGATGGATATGGAATATCGGTGTTTAGTAACATAAGTAGCAGGAAGTGAATGGGTGC 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-GTTGTACTTCGTTTCAGTTACGTGTGCTTCTGTCTGGCAGGCTCGGAGATGTTATATAAGAGACAACCGTATGCCACCTCCGCGTACTCTCTGTCCAAACGCGTCGATAAAGAGTCTTTTCTGCAACACGCCCCCAGCCTCATAACTTTCAGTACCCGATCATCCAGTCAGTGAGTTAACTTTCTTGCAAAAAGGCTGCCGCCGTAAAACCGGAAACGGTCTGCATTCAACGACCACTTTCTGATTTCTGGTCTTTCTGCCGTCAGACGAACAGGCGGCGGTAACCCGCCTGCGCGTATTACGCCCCCACATGTTTTGTCTAAAACATGGCTCCATGTGGCATGGGTGTCAGGGCAAAGCCCTGATAGATTATACCAATAGCGATGCATGTATGCGCGGTATAACAATTACTCCCTGCCTAATCAGCAAGCTCGGAAGTACCGACAAAAACACGGCAGTTTTGGCGACGGTGTTGTCTGGCAAATCACGTCAAAGAAAGACAATCACCGGTAAAACGGTCGAAAAGTGGTACTCGTCGTAATCACAACGCAGATGACAGAAAGAACGGAAGAAAACCAGAAAGATGTGAACAAAGCAGCAGCAAACCGTACTCAACATGGCGGGATTCATAAAAGCCAGAGCCTGAGGCTGCTCGAAAAACTGGACGCGCGAACGGAGCCACTGTGAGGAAGCTGCACGAACTCAGGAAGAACTTCGGAACAACATACAGACACACTTTGAAACGGAAAATCGCACCGGGATATAACGCACCCGGACGGGATACAGAACGGCATAGCGGGCACGTGGGAAAATGCCACATCAGACTGCTCTTCGCTTCCCACTCGCTCACTGACTCGCTACGCTCGGTCACGTTTTCGATGACGCGGCGAAAGGTCATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCGGGGATAACGCCGGAAAGGAACATGTGAGCAAAAGCAAAGCACCCGGAACAAACCAGCGCCGATGCCGTTTTTCCATAGGCTCCGCCCCCTGACGAGCATCACGAAATCGACGCTTCAGGTCAGGGTGGCGAAACCCGACAGGACTATAAAGATGCAGGCGTTTCCCCCTGGAAGCTCCCTCTTGTTCGACCACCAACACCGGATACCGCATGCCTTTCTCCTTCGGAAGCGTAGCGCTTTCTCATAGCTGCGCTGTTTGGGTATCTGGTTCGGTGTAGGTCGTTCACGGCCAAACTGGGCTGTAATGCACGAACCCCGTTCAACGACCGCTGCACTGCTATCCGGTAACTATCGTCTTGAGTCCAACCCGGAAAGGCACATTGCACCACTGGCAGCCATTGGTAACTGAGTTAGAGGAGTTGAGTCGGGAAGTTATGCACCCCTGATAAGGCTAAACTGAAAGAACAAGTTTGGCGACTGTACTCTCCAGCCAGTTACCTCAGTTCAAAAAGGCGCCAGCTCTATGAACCTTCGAAAAACCGCCCGCAAGGCAGTTTTTCGTTTTCAGCCCAGTTGAACGATATCTTTGCTTCGTCAGCAAAGCCTAACGACTTCTAGCCCTTCCCGCACAGGCTGTTGTAACAGCTCGCCGTTGGGCCTGGCACAAGTACCATCTTTGGCGGGAATAATCACGCCCAGCAGGCTCTCATGACATCATTCTTGATCTCCATACTTCTCGATGACAGAGCAGAAAGTCTGTCGCTCATGATTCTCCCCAATTTACAAACAAAGCTCTTTGTCGGGAATCGCTCTTCAATGTATGGGGGCATAAGTCAAGTCCACAGTGGTATATTAGCTATATCATACTCATCATTACACGCACCAGACATAGACTTATAGCCAAATTAACATCGGACTCTTTTTCTTCGCCTTGCTGGAAAACTCCACACACCATTATCAGCTTCGCACGTTACATTCTTTGCGACGTCCACCGATAACATCAACACACATTCGGTTAAAGCGTTGGTGAAATTTTGATAATTTTCATTTATGGCTCTTGATAAATGAAGTGAAAGCAGCGGAAAACCAAAAAACGTATCAATGAATACATTTTTAGGAAGGTATCTCTTGCGCATGAATAACCCAATGAAAACTTTATTACAGTCTCTTCAATTGCATGATATAAGTATACCCATCAATAAAGCACCGCCAACGCGTTTTCCGATTTACTCAGTGTTTGTTGGTTGCTTGCTCTGTTTCATCTTGCCATTTTGACCTCTAGATTGTAAAAGGCTGCATATGGTACACATCACCTGGTTAACAGTTGTGCATGGACGTATCAAACCACGGAAGTTTGCTTCAAGTGCAAACCTCGACTTGGTTAACTAAGAACATAACTCTGGTGATGATTCAACAGTTCTGTAAAGAGCGATGATTTTGTGTGTTTATGTAATATAAAGAAGATCACCATGTGCTACCTGACATATCACGTGTAAAGGGTAGTTTAGGTGTAACTGTTCTGATTTTCGCGAGAAAGCATCTATGAGCACAAAAAGAAACACAGAAGAACAAAAAAAGGGTCATTAATCACTACTCACTGGGAGATGGTAACCAGCACATGGGTGGACAGCTATACCAAATAGCCTCCTTATGCTCAGGTGATCTTGGTATTGGGAGTACTGAGATGTGTATTCTGCTGAATATATTGATGCGTAGCCTGAGTCAGGGGAGTCAATATCTTTTCCGTCAATTGGTACCATTGCATCAAGAATAGGTGTATCTAAAAATTCAACATAGGTTAGTAACCTGGGGAGCATTAGGGATATTAACTAGATACCAATGTGAATGACCCCTCCAACAATAGCGCTAATATATATTCGACTCAACTCCTCTAAAGAATATTAAACTCAAAGTAGAGCATAACAATTAGCAACAGCAACAAAAGAAAGAAAAGAAAGAAAACTGAATTACTAACATAAAGAATTACACATTTGCCCAAAATGTTTGAAAACTAAAACAATAATATGAAGAGATTATTAGATTTTTGGCGTGCGAAAAACAATGGCTGGAAATAATAATTCATAATGTGCAAAGAATGCGAGCTGAAAAGATCTATTTTAAACAGTTGCTGGTATTTTTATGTAGCCAACTGCCCCATATTAAATGGGACATTTCAACGCTCCCATTTACCATAACGATCTCATTACGCGCACCGCAGAGCGCGCTGAACGCGATTCTGCGGTTGCACGTATAATGAGACGTTATGTCAGAACGTTAAATGATCGTACAGTGAAACGGTGACCATATAAAATGGTCAACTTTGTTAAAACAGATCTCGCTTTCAGAGAAGCTCGTCTTTACGATATGAATTTGTGTCCCAGCATACGTATTATTGTTTCGCGCATAAAGTTCCCATTCAAATGAAGGGCATTATTATTAACGGAAGGGAAGTGCCGCCTGGTTTCAGGCATTTTGAATAATCGTAATTACATGTTGAACAATTCCAGTTTTCTTTTCTTTCTTTCTTTTTATTGCTGATGCCCTTCCAGCAAATATTCTTTTAGGGATTGAGTCAGTATATTAGCACTCGTGTGGAAGGTCATTCACTGACAGATATCTAGTTAATGTCCCAATGCCCTCTAAGAAATATTTAAACAAAAAGCTAAAGGAAGCAACAGTGCCAAGCAACCCGGCAAAGAAGAAAGAAGAAAGCTTGAATTCCTTTAATTGGCGTAAAACATAAATTACCACCATTTTCAAGATGTTTGAAACTAAAACAACCAATAAATTTGTTTAAATTTTTTGGCGTGCGAAAAACAATGTGGGAAACCGTGAAAGTTCATATTACAAAGAATAGGCTTCTGGAAAAGAGATCTATTTTAAAAACAGTTGGAAAGCCTGTTTTGCTAGCAAGTAAACTGCTTTTTATAAGTAAATGGGACTGTTTCTTGCTCCATTTTTTCCATATTACATCATGTTACCACCGCGAAGCGCGCTGAACGCGCCGCGTTGCGGTGCGCAATGAGACGATCGTCATCGGGCGCTATCTCTTCGCATGCCATACTCTACACATCTGACGCGCTGCGGCGGTATTGCCATATATACAACCAATGCGTA 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-TGTTGTACTTCGTTCAGTTACGTATTGCTGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAGACGGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACCGAGATACCTACAGCGTGAGCTGTGAAAGCGCCACGCTTCCCGAGAGAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGGGGAGCTTCGGAAACACCTGGTATCTTTATAGTCCTGTGGTTTCATACCTCACAAGCAGGCGTCGATTTTGTGATGCTCGTCAGAGCGGAGCCATGGAAAAACGCCTGCGGCGCTGGCTTCCCTCCGGTGCTTTGCTTTTTGCTCACATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTTAGGAGTGAGCTGACACCGCTCGCCGCAGTCGAACGACCGAGCGTAGCGAGTCAGTGAGCGAGGAAGCGGAAAAACACCTTATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCGGGTGCGTCAGTTTTTCGAGCAGCGTCAGGCTCTGACTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCTGCTGCTTTGATTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCTTGGCTTTTTGACGGGCATTTCTGTCAGACAACACCGTCACTGCCAAAAAACTGCCGTGCGGCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCTGGTGTTATACCGCGCATACATGCACGCTGTACGTTGCCC 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-TGGAAAAACTTTGCCTGCGGCGCTGGCTTCCTCGTTGCTTTGCTTTTTGCTCACATGTTCTTTCAGGCTTTATCCCAAGATTCTGTGGATAACCGTATTACCGCTTTTGAATTGAGCTGACACCGCTCGCCGCAGTCCGAACGACCGAGCGTAGCAGTCAGTGAGCTGAGGAAGCGGAAGAGCGCCTTATGTGACATTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCCTGAGCGTTATCTGTGCCTATTTTCTCACTTCAAAGCGTGTGGATGCTGTTCTGGAGTTCTTCTGCGATTCGTGCAGCTTCTCACACATGGCGGCCTATTCGTCCAGCATCGGGTTGCGTCCAGTTCCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTTGGTGGCTTACTGCTGCTTGTTCATCTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTTGTGTGATTATATCGCGTACCACTTTCGACTGTTTGCTGCTGCATTATTCTGCCGCTTGGCTTTTGACGGGCAGTACAGCAGACAACACTGTCACAGCCAGAAAACTGCCGATGCCGCTGTCGGTAATTCAGGCGCCTTGCTGACAGGACAGGATGTTACGGTGTTCTCACCTTTGCCGTACGCTATTGATGCCTAGTCGAGCACTGCCCCGACACCATGTCAGATGCGAACCATGTTTTATCGTTGAAACGAAGTGGAGTAATACGCGCGGGCAGATCAGTCGCCCTGTTCGTCTGACGGCGAAGACCAGGAAATCAGAAAGGGCTGCTGAATGCGGCAAGACCGTTCCGGTTTTACGGGCAGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCAATTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGGACAGGGAGTATGCGGAGGTGCCGATGCTACATACGGAGAATATCACACCGTGCCACATTATCCAGACTTATGTAGTTAGCTTCCCGGAAAGCTGTCAGCGGTATGAACACCGTAAACTCCCAAAGTGATCCTGCCATTCGCTTTCATGCATGCTTATGCAGCGAGCTGAAAAGCGATCCTGACGCATCCTTCCTGTTTTCCCAGGGTAAAACATCTCTTT 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-TGATAGTACTTCGTTCAGTACGTATTGCTGCGCGCACTCTCTCTGGTCTCGTGGGCTCGAGGATGTGTATAAGAGACAGATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCGGGTGCGTCCAGTTTTCGAGCAGCGTCAGGCTCTGACTTTATGAATCCCGCCATGTTGAGTACGACGCTGCTGCTTGTTTCATCTTTTCGTTTTCTCCGTTCATCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTGACATACCCGCTTGGCTTTTTGACGGGCATTTCTGTCAGACAACACTGTCACTGCCAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCATACATGCACGCTATTACAATTACTTTGCTCTCTTATACACATCTGACGCTGCCGACGACAGAGTGCGCGCGCAGCAGTACATGGC -+ 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--?)%9'7;;IB>5<@70//.DE?8F;<<8<-.8@>+$32($B;?@;:?5*,.+480?AAIEIG856A<=@@;D.43?<>=::C;B<>D:8<;:=:>@?=?9ADC,5,;:8DIFDC?@?<;B:9.4AIHA?B?;=?=DICCDGD<>@ALK6A@LGO@;@:C;MDC?<:A=<>C<:@:A)@HKBC=AFEFGAD<:@63.,:.CC@LMMF93(%8:84794?889FB=>>@+08BCDE>=+4%%801@;7C/56.00-655<;;>B@:7<)4(@65$+A@D,6(4..-3;/2>====,$&,58@A<45-(*0*+==>;6++(*$0/*17832)9E>BFE>30*)'&##$$0=>;/2+&?9>F<71%%,8:8;F::B?CGHECJKHB8%%13D5686;@??DFE954802+9%'%%+-1,16@;DDF.C@@G4-306.3%&0%%2.=A<;5D9:A80BB:?C4-).A@BC?<51,.+))2.1.28/@;?22:;%*4;MLOIDJI<>ED297-9B@00C9<:,-/59+01=:;;FB6?>DJFJEBEA=8D59=GF==?<730*(<*,//4*7996$&&,0+2877$$69:99;?G>9=ED9>=@85+/0=:>;A<>&9=7;9>?<8=9579:;<9=;<8@DD@FA@AB>62CBB<:2.&5855C?962@@A;;2+;0HBG@=<;=>9<=>DB>;?F,0)'4B??>?BDEE>ADF@LHI -@fcf49bdd-1b50-473b-acae-e35494b55ed4 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-@ece40f73-48e4-4d5e-931b-efee0e570ddd -GATGTACTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGTCGTCAGCGTCAGATGTGTATAAGAACGGTTGTTCTGGGACCGTGCAGCTTCTCACATGGCAGCCTGTTCGTCAGCATCCGGGTGCGATCCAGTTTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCATAACAGCGTTTCATCTTTTTCGTTTTCTCCGTTCTGTCTGTATCTGCGTTTATTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTTGACAGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGCATCGGTAATTCGAGCTTGCTGACGGGACAGGATGTGCGATTGTTATACCGCGCATACGCATGCACGCTGTACAATTC -+ -'$($,/12-)-C83.;7/1,$*//**)/,*%%%&;>45+),-&70,#$'##$%,#%+03+)%,*27:@D->;98<;75A@:?B<;8A:1>B:&&?3.55/1%%&&8.<68?7.4,(+52:8266,5GH3C/JC77)%%%*+%%&%%67288900@02'5+';:<676*$$$++-,;>@FC;D@)?=F652+06)&$048()<9==,$%&&553A:+&%14:>?@??A)9:=>>>787:AAAMKBCJ?=?;KI?B><62.83$$)6>33?C:8690*&+4??BDCC@0(9''@=?63=;<2FED?FAAED?/(<,+,-/'"&*6A16=>D>@>;93@AC?B7G@D).D>6/==82,2+&%#$&-(**)-?@@?GE?<<=$$((($%1--7'3/78:46( -@5bb760a4-3566-402d-a25b-b0674ea4c1c4 -GTTGTACTTCGTTCAGTTACGTATTGCTGCACGCGCACTCTCTGTCGTCGGCGGCGTCAGATGTGTATAAGAGACAGGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAGCACCCTCCGCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTTCTGTAACACCCCCAGTCCTCATAACTTCTTTCAGTACCCGATCATCCAGTCGGTGAGTTAACTTTCCACCGAGAGCTGCCGCCCGTAAAACCGGAAACGGTCTTGCGCATTCAACCCAGCCCTTTTCTGTTCCTGGTCCTCTTCTGCCGTCAGACAGGCAGGGCGACGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCGCAAAACATGGCTCCGTATCTGACGTGGGTGTCGAAGCCAAAGCCCTGATAAGACAGTAGCTAAGCGTGCATGTAGCTGCGCCCGGTATAACAATTGCACATCTATCCTATCAGCAAGCTCGAATTACCGACAGAGCCACGGCAGTTTTTAGCAGTGACAATTGTCTGACAGAAATGCCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAGCAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACAGAACGGAAGAAAACGAAAGATGAACAAGCGGCAGCAAGCCGTACTCAACATGGCAGGATTCATAAAAGTCAGAGCCTGACGCTGCTCGAAAAAACTGGACTACACCCGATGCTACGGCGAACAGGCTGCCATGTGGCGAGAAGCTGCTGCTTGTTCATCTTTTCGTTTCTCCGTTCTATCATCATCTACGTTAATGTGATTACTGTCTCTTATACATCTCCAGGCCCACGAGACCGGAGTGCGCAGCGGTACGTAACT -+ -((*)+)666<;G(/',758;EG;:-)@+A?9733FFFA?:=@CDC-)B>;:><:6<:A8B:896856--:>IKC;>9'),0669:<:;?;=@=>7&%&(1.08986**))92@AF;664''6-=+***(.5--/&414>92C8>?;ED$$C>?9A$*)%)857-0/79=27>;-200,/999<>566C<8?EAAG0#%%+$694-1*&#(%%&146466>>B5-''('++-..%*$%(()*04B<<9?$$9<<7=,:7?DF26?C62E5B86.B.0.F=40&$%-&4,-,%%%$%%'$#$%&&%$'%''$&&0:7B7=42*.'/0:782(//$*351,,=&'&(;90=-$;(%((++$$9207&'0575,,88?6:40141--,+506,54-:1596-%.+(.4-)(')')&56131,1+33=67KOG??9=?H=677<12::<=9<5CFC@?;45.5%@557I@DFAB??BFFGG>75>1/1@DC@'546B24%'(&.8&0B89B4A:;,$<=6CEA9:EKI==:2;,3?CC@A:3.:D:.2::@AAFCD=8'(0#$%&''''=A>8/,%%%%055862>D?D;9=.50-+&$*&8$:6:;3237344*389<:::632%).042<4;'6;61+3*5:A:7@/+/8<>-.8821+)-&$+%((=><=72.E?:=9&4&&3ABA4520><74$('4<)AH?9<7$,,..$$/1,( -@3d165071-e1ad-4397-bcc5-e460e130f807 -GTTGTACTTCGTTCAGTTACATGTGCTGCGCGCGCACTCTCTCTGGTCTCGTGGGCTCGGAATGTGTATAAGAGACAGATTGTAATAGCGTGCATGTATGCAGTATAGCAATTGCACATCCTGTCCTGTCAGCAAGCTCGAATTACCGACAAAGCACGGCAGTTTTGGCAGTGACGGTGTTGTCTGACAGAAATGCCCGTCAAAAGCCAAGCGGCGAGAATAACGGCAACAAAACAGTCAAAGAAGTGGTACTTGATATAATCACACAACACCAGATGACAGACAGAACGGAAAAAACGAAAAGATGAACAAGCAGCAGCAAGCCGTACTCAAGCAGGATTCATAAAAGTCAAGAGCCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTAGAAGCCTGTCTCTTATACCCCCACATCTGACGCTGCCGACGACAGA -+ -&(**-.453;>I+2+3=>;:&&%*$496,0*-&16356+/-+0/./,,(<7G7>G=3<.4%.),:=<<9+,*&,'++*')3,(59=9B@@DD?<;6,+)'(%%('.9$=6659;D=AF00>C?66<50-@A9>23=@955./=A9E@=BBDF/+9%%031.<9=OF/34',>=8<(280/2+0>7H@,-*0?I;>B:229=FFA;7==775:,1,$%(2A?<;??AIA0,/(;*,)&''8?/1;+&&&:9CGH;:78/:44<<9$$6/A?@@6A9:G8>6A<:/3.04(@CC?EI@/9FG@>CEFG:51>7>5?>?76*'$%$*8.%$$((9/BC>10?@B06>A%&180CCBC<96:@@H@69>B@C@=>9?D;124666>BM?9@E@6++23<>JCHFBD1//573400/2756'56?>770-*02123(<;8,/44<215%%'$3BB'&3)%%%'(,8=.+++2/@E:<<>;@>?@<@@;9;<;=@515%#$&'*&%&#')122DC>950&#%'$&)+,2::5$%+&1038F>;=C;-44@E?ABBBB@@2/27/.:;:77,7$/,.6><@HG@;2-1&*(8267=??A.*8($&%,27;12*572)),)+1258:>?<&&@*0(%'..'%'%$$*22367@H87(),61'((-)&3-&&%&=:2.'&&%/$$"'*+8;40)$0##$($&&$$$$#&65@=703.4?0':;6&'(')%%+463$%'*9C<992544==>@:>>1>B@BHFFC8;<<=+34000-2-./.*45,)&'*(&$%'(*#%&';@AB<)256:=2+=.A;G-46847:'(@9;;>4*/?3D44<2?3%/C@FEB>@6C:9$$2013,.*45>7?;E29:?ACGC??5847*+$%*(+)%?+12$%$-2,14=@9920&$*$4:844%'34-(5$&$<'*(((393;:>=?E@:8:<5<(/:BBCLF=<,,:8@AI@A=BCGF><>?C$-:HD4.*?<;@&',')-(-),84359352314/'153,))*#$4'46)+&.%($%(01.?9A@@A=>U658'%0014021*)3:?A:7;7; -@f14ca0e8-faaf-4e9f-b5ce-5d4874aa0bc1 -AGTACAGCTTGCTGCTGCTTGTTTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTATCTGCGTTGTGTGATTACTATCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGTAACCTTGGCTTTTTTGACGGGCATTTCTGTCAGGCGCTTACTGTCACTGCCAAAAAACTGCAATACCTTTGTCAGTAATTCGGGTGCTGACAGGACAGGATGTACAATTGTTATACCGCGCGCCACATGCGCTTCAATACAATTGCCCTGAGGTCGGGGGCTTTGCCCCGAACACCCATGTCAGATGCAGACCATGTTTTGCCAAACCAGCAAAGTGAGTAATACGCGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGACCAGGGAAATCAGAAGGGCTGCTGAATGCGGCAGCAAGACCGTTTCCGGTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAATAAAGTTATGAGACTGAGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGAGGACAGGGAGCTATGCGGAGGTGCTGATCCTCATGCGGAGTATCACCGTGCCTATCCAGACTTATGGCAGATTAAGCTTCCCGGAGAAAACTGTCAATAGTGGTATGAACACCGTAAGCTCCCAAGTGATCACCATTCGCTTTCGGCCCGCATAGCTATGCAGCGGGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCAGGGTAAAACATCTCTTT -+ -,.;6/-88899=@>9;95888658;=??@>;>9*116I;7<7@=DAD>999/($&-/))(%%%(($$%$3-%%*))*(.05628???<5208;:@>B7(%.9==7BECAA;,,(''&*&'%*+9:===;:7/$&5>8>CC82,&0$%*/-///@??62.&(,***430010,.**%%((/2/?5-+&&&&+)%&&0)1437/,%&<45397>>:07'(./1$',,%&&&'((%$$&'')0676-33.0%'4=5)2)7A@3?ABF?:0).(,''%%&7.0,)18+(;40*337$><85034D)*<:9+&2*+(93@?A8BADC2,?1@,,*.3((1+;;685<87%+<:<<69:%4=@DB:884;8:=49,-)4'((6;>;A;;'<&*).7872>7AKHA8D@BC5+-,)8??=CJDC<2534@D@=>>EB,*3)-??>@A/.3/88DBDA<83214;9:81(.2314%02<43<)/;D:=1()%%'$$+2108-/%%'@315;4%%,$&$%'4%($$(0/:44415+0-%6//B66CBGEBB00(1'+*/$&56675>=+,-&2*-(%$$%)$%$%',$&))6763-25857..5BB?BD67/54.+:,01<><:%$=@51%%%%%$&&&'-1+6/..*;:%'10225EB>?<=--2266@339:;@EB>?B?>>??-1%0-6/+-1?A?$*&,1:8976662077-*)))$1&%5)4:?4657270D9>FE4=9=@=@?@A47:&%=BDAC0>?.&91/5<=9.7-;@932:,GG<3A=>B>=I72IACCC=??9>?95-)4;A:888,/%.(''()(1019>68;3541*''3AFMHF?;AJOHE<;/5)G@E:;>>2>F@?B)@:??A@?55AD@<88.5++(1:9;E<>660(*)&20044066?;;@78:A335-031?00&&$$11-:B79DD+(/42:8EFB<9<==26>==LG@>%+-<;AC/$%/034-6<99A=OKJ0>9CC:C77@2E?52GD?C<>D<<899@@::79:6:BC?:E>?FG@/6;27./,#$*$$'5@E?112?B?=CGC@AG<564)-2/1ICA@:C/B$)*-&&8:DE>CFAGH@A>?<;=2?AB>><-*A420035E@?CCD>EJ)+:9?/3DEDFA@?7?=6B').84'-878HGD@A:??:=>=720''5=A?@CDA?;;679>=7C>+-(1BE6<>BJJB>H>BCFC411426:=//CED+(%$$*3278B-/748:?9:?;//23080'+78::=96''@>CBA?HAD<<89646>>?@@D:9:@ECLI<>8427ACD?1$>9>EG=C=C>8EA81?%*657134567,#$,&&%'$#&)&4&#$$((.74A;:5994@=@=;?*..,000,+&)37A=>DF)$?7?E=>A@84../03+,))(>AB',AA52.&&87&&0.;>;=ACABFAA8@A>?=+*%3)2/(4=9;>>?;;=8C80B9FD5FEHC:<@FCFE;=<**@@@??FDD82)- -@d070ef6f-29a5-43f1-937a-75bc0417dd59 -GTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTTCGACTGTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACTGAGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACGCCGTGCCTTTGTCGGTAATTCAGTGAGCTTGCTGACAGGACAGGATGCAATTGTTATACCGCGTATACACGCTATTACACAATTGCCCCTGGTCAGGGCTTTGCCCCGACACCATGTCAGATACGGAGCATGTTTTTATAATAAAACGAAGAGGTGGAAGTAATACGCTGAGCGGGCTATCGGTCGCCCTGTTCGTCTGACAGCAGAAAGAAGACCGGGAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTACCAGGCGGCAGCTCTCGGTAAGAAAGTTAACTCGCGACTGATGATCCGGGTACTGAAAAGTTATGAGACTGGGGGCGTTGAAAAAACTCTTTATCGACGGCAAACGTGTCAGGGGACAGGAGTATTGTCTGGAGGTGCTGATCCTTACGGGTATCACCGTGCCCTGTTATCAGACTTATGGCAGATTAGCTTCGGAGAGAAAAAACTGTCCGAAAACAGACAAATATGAACGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCCAGCTATGCGGCAGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTTCCCCGGGGTAAAACATCTCTTT -+ -;?==:;?.;0;<=>12;<8A9/20==?A?=5016%%5388=8?A50.()<AA95$(('&-28;9:?B<,/);-*)213''.6:5>9A@:55980/&&(++(6<=<5--/(%)4&(&,)99<32113.)?<9BED?47781964:5675186.1:44;'-%*9134??A=*$*$+$468/5$$+&&&-979>70/+,++74'%'$/7%*6=?0,7'.9:::44;4C=E8:?3,&;?G;44,36:GC4,:1%2./,+'.,/87636669:54$$(%'*5$$$$133467;D;;;:4*<>3093E?245@D,61<27+1+++6-96:::<-71)550,,0$$2%&&&%.*+*'#%$%%'+*--33&'6???J=@A5>AC-&6+-3B>A<55>3=<=@E?>HCB5'2$$$$2-57161%$--949;=B?>))$''&'&'.'(,.,,386=?A2*3%%B:55)&&$..++,2264>@AD77(,;&(*)(0=<6+4-52&(),,9@716@=11$$+1<77$-(*+0.'419>*0/255:@=>=>8=9===?JF(5--+00****'*'$'$)%)*',(4@=?7-%%%&%%++68@AC;11,6+/%#-)CHC?FH65&*2-285((*3$&2)2&&.%,('%..4$&+&&(160*&$0)-%*($035553012-(**3;*++,*6&0.-(*$#&9=.A=6+/21%$$%(7<<01,'*9<8*)*,)/-/.47A9;?08,.+$+%$)$%&%&',(08<:288A,E655649,,37=BHE?92:'(7:;<;9.,-+.'04**--&4')%(%&)03D5/>-12-+)&1+013#%/,.,&$%,.+).#%1%(%(&'(+21B0+'.%$$(+4*<.4255((602/321-3(()0'%((,*$&$$%##'&,50+%%(66)6%&('&&*$%489468:0+5BECG48>?;<84@6A?D))EIH88KJB<=??>/*))7:01-8/318/7DD::C=EF/0C8974,%#-.('),++.>,.+'##$-,/+*)*&5%($#&%##))(..+)*))77 -@df89b955-2400-4adf-91be-adf7e99293a6 -GTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACAGGCATTTCTGTCGAACAACACTGCTCCTGCAAAAAACTGCACCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCCACATGCACGCTATTACAATTGCCCTGGTAAGAACTTTGCCCGACATGTCCAGATACGAACCCATGTTTTATGACAAAACAGGGGAATTAAGGTAATACGCGCAGGCGGGCTATCAGTCTGTTCGTCTGACAGCAGAAGAAGACCAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTTCCGGTTTTTACGGGCGGCAGCTCTCGTAAGAAAGTTAACTCACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAATGATGTCGGACAGGGGAGTATGCGGAGGTGCTGATCGCTGTACAGATATCCGCGTGCCCTGTTATCCAGACTTACATGGCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACGAACGGGCATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCGCCGCCAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCAGGTAAAACATCTCTTT -+ -6//:86621:93607;A>HI8>AAHB=?;CF7HFOK?@D878:HH@A>;14=A<**17>,,---+0))))/9>ABA9/0/1''/./+3%$(++-,2356BA>:6+16%$(84.=/+.+.8.%<&+98;8@<66?A@?-*).*),+=:4/>B=D?55B:<:@8@=22256'(*%)%+/))-2957810/36>?:E7?>((-.,$&',,::<<$57/%$%//.$$=;=ED?49//><98AEFDG@=A@EDBEB4*&&$$#-'&(%&(1768;?>/++(*+9<$'&-463:726=;:AB<5.=5HE'$::,,73/+$&3++&-/&-1230/9493')7<<<>=:52<0/;'.A<>@F?C>B?B=7>31DDLHD??.3@?&-*%,''&%$%-**'6/'22>77;<:C::97A@@<<46=,>=AFA:=;:33>?J=>8.69>@EBA>H149@;C=>=&*&)$,$33$$*&*)6(BCFJ@KHD++F9=D>A<$$9A9?>33?CDD>BDD6;C30-(&)DEBEB==?;4%%*<',**'&*)*+4697968'23'339;><>=409124=FE=@;A@F=<=A/%%+-0*.*(%2378<37;;::B?.1''&%,.4./9:?;<679 -@db9ace37-06f6-44a5-bee7-48352260fd12 -GTTGCCCCGTTCAGTTACGTATTGCTGCGCGCACTCTCTATCGTCAGCAGCGTCAGATATGTATAAGAGACCAGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGAGCATTTCTGTCAGACAACACTTTATCACTGCCAAAAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAGGGCTTGCCCCGACACCCAATATCCAGATACGGAGCCATGTTTTATGACAAAACAGAGGTGGAAGTAATACGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTCCGGTTTTTACGGGCAGCGGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGAGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGTAGTATGCCAGGGGGTGCTGATCGAGCAATACGTA -+ -&#$$%%%',,3*%1))&&%0%1498?;E62..$&2+06-'6>;?4-851@GB>:37..*%&,6@:;'2*7(1).CDDDGGFE>E7.(BCDF<<>?AA:489=:21&':5;960$$'*&+7?;;9,-;:889968,55488&*&)6,):,0<8:9-2$$.EML442BA84:DD+'<<>>$D9A::9>B@?=>=476:DDA;>:0/.-179:5-.23=138>?EFC?).5,$2418:9***/65>;7342#(..((>4881-+#&%#/1'&&::<;ADBB=@?,:D??C??92295AFD,/./11;61:8<1=>FDFDD@60?0KED2;,7+3''('1-(1-4137A:BA;>0:42(>DBC9?4@-2//,.6<:=?C;B:@<)/1:GFNKEFC27?,(=B-3@C>8B**9:E@A@BLLE=99::6.2+2DCC>?C9GHJF>:@9>57E9A>73A2,F%&';4+(<@D=@==;6'.'0,+,(%&-(/-,5**+:;8?@A:'- -@467ed196-ddc4-4852-b780-773b91fd58c5 -GTTCGTTCAGTTACGTATTGCTGCGCACGCGCACTCTCTGTCGTCGGCGGCGTCAGATGTGCCAGAGACAGGTCAGCAAGCTCGAATTACCGGCTCTTTCTAAAGGCACGGCAGTTTTTGGCAGTGACAGTGTTGTCTGATAAATGCCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAACAAAACAGTCGAAAAAGTGGTACGATATA -+ -%%&27>0>=:97$'32'$%$&)(((*+473CEA=B>=>%'%%2:@=;083,))%$%+'/-7:19D9:0:@79>?87-5.<;7=:-.//+&&&'&*+&*77'.*03.C=@DB>(-5/5DEG3,6BG@>3/4%%#%/078824=52054.,+).1597E8=956.@<223&(('(7:<>B9::37004A>82>786/.+*-,)) -@d10aeab1-d358-468f-aafc-bbe34e3dc5e3 -AAAGAGATGTTTACCCCGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGGAAGCGAATGGTGATCCTTTTGGGGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACCCGTAATAGCGATCAGCACCTCCGCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTCTACCAACGCCCCCAGTCTCATAACTTCTTTCCAGTACCCGATCATCAGTCAGTAGGTGCTTTTTCTTACAAAGGCTGCCCGCCATAAAGAAACCGGAAACGGTCTTGCCGCATTCAGCAACCCCTTTTTCTGATTTCTGGTCTTCTTCACCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCATAAACATGGCTCCGTATCTGACATGGGTGTCGGGGCAAGCCCTGATCGGGGCGGTGTAATAGCGTGCGTGTATGCGCGGTATAAGCAGTGCACATCCTCAATCTGTCAGCAAGCTCGAATTACCGACAAAGGCACGGCAGTTTTTGGCAGTGACAGTGGCATACGACAGAAATGCCCGTCAAAAGCCAGAAGCTGGCAGAATAGCAACTGACAAAAACAGTCGAAAGTGGTACGC -+ -3+&(35;=2HE2%&&&&)%(1-)&0,46/17@098;7-<>:BD><;69,/645%%-$)((#%)&(((/(()7(629,,-9?;=ACBEEL?B?=615BA<;8&84<,/2/+':;>=6@:2**'87986</03/9733&,.6=655.'71/49:-(.-.3-646B=<;>62*,+('+7450211;;<<;9??86==9==9=??BAEF+&.@KHH37&$$$$)>=BB@<)&)2407.366,,4/456$-/8@<<=;8<6C2.0.(,0&46***7(''(),+++*%2(,%++-/&-32$')%%::.&,-,7;,.*15A%,00++*/-+744,**%+$%12324:;;96454A@)42$.77DA;?-)&'(93A9;>B?:=;3>,::8533<8/2.9:=)'%$$4;A<>:86.:<8%8568:==BAJD5,<+/56&=.?,3?A2=8=2/4(1)&%0,1-<6-.(,)'%$&$57,+.+%%%'&%,#$2,-%%3.40-40)&&$#&&(4*1041'%%&$($$?9:0@6$$-$&$%';5-()%%()+&<21%%&&,%0278?;<$38=7&&'-'6?AEBA+2-&0883,(-2)'&'%$$&&---;@@67BAF:4?EL<4511+&)%%%&(+*)(%$%'&-$%%$'&.,,,'%/%0,)$$$$':/2-(5/1 -@2c0c3f29-ad59-4642-a9b4-4898a8b16456 -AAAGAGATGTTTTACCCCAGAGAAACAGGAAGGATGCGTCAGGATCGTTTCAATCGCTACCATGTATGCATGAAAGCGAAGATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTCTCTCCGGGAAGCTAATCTGCCGCCAAGTCCTGGATAATAACAGGGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCGCATGCTCCCTGTCCCCGACACGCGCTTGCCGTCGATAAAGAGTTTTCTCTTAACGCCCCCAGTCTCATAGCTGCTTTCAGTACCCGATCATCCAGTCAGTGAGTTAACTTTCTTACCGAAGCTGCCGCCCGTAAAAACCGAAACGGTCTTCCGCATTCAGCAGCCCTTTTCCTGATTTCCTGTCTTCTTCTGCCGTCAGACAGGTGGGGCGACTGATAGCCCGCCTGCGCGTATTATTACTTCCACTTCGTTTTCATCATAAAACGTGGCTCCGTATCTGACATGGGTGTCAGGGCGAAGCCCACAATAGAACAGTGTAATAGCGTGCATGTATGCGCGGTATAACAATTGCACATCCTGTCCTGTCAGCAAGCTCGAATTACCGACAAAGGCACGGCAGTTTTTTAGCAGTGACGGTGTTATCTGACAGAAATGCCATCAAAGCCAAGCGGCAGAATAACGGCAGCAAAACAGTCGAAAAG -+ 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-TTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTGACAGGCATTTCTGGCGAACAACTTACTGTCACTGTAAAAAACTGCCGTGCGGCTTTGTCAGTGAATTCAGGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCGCATACATACGCGCTATTACAATTACTTTGGTCGAACTTTGCCCCGACACCCATGTCAGATACGGAGCCATGTTTTATGACAAACAGAGGAGTGGAGTAATACGCGCACAGGCAGGCTATCCAGTATGCCCTGTTCGTCAATAGCGAAGAAGACCGGAAATCAGAAAAGGGCTGCTGAATGCTGACAAGACCGTTTCCGGTTTTTACAGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAGAAGTTATGAGACTGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTATCGAAGGGGGACAGGGGAGTATGCGGAGGTGCTGATCGCTATTACGAATATCACACCGTGCCCTGTTATCCAGACCTTATGGCAGATTAGCTTCCCGGAGAAAACTTTATCGAAACAGACGGTATGAATTACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATGGCCATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCAGGGTAAAACATCTCTTT -+ 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-AGTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTGGTCTCGTGGGCTTCGGAGATGTATAAGAGACAGGTTCATACTGTAATCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAGAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCGCGCTCCCCTGTCCCCGACACGCTTGCCGTCGATAAAGGGTTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCAGCGAGAGCTGCCGCCCGTAAAGGCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTCTGCAGTTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTGTCATAAACATGGCTCCACTGTCTGACATGGGTGTCGGGGCAAAGCCCTGACTCAGGGCAATGTAATAGCGTGCATGTATGCGCGGTATAACAATTGCACATCCTGTGTCCTGTCAGCAAGCTCGAATTAAACAAAGGCACGGCAGTTTTGGCAGTGACAGTGTTGTCTGACCTGTCTCTTATACACATCTGACGCTGCCGACGACGAAA -+ 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-AGCTTGCTTTGACAGGACGAGATGTGCAATTATTTATACGCGCATACATGCACGCTATTACAATTGCCCTGGTCGGGCGCGCCAACACCCATGTCAGATACAGGAGCCATGTTTATGACAAAACGGGGGTAGATGTCTGCGCAGGCGAGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAGAAAGACACTCTGAATGCGGCAGACCGTTCCGGTTTTACGGGCGGCAGCTCGGTAGAAAGTTAACTCACTGACTGATGATCGAGTACTGAAAGGGGTTATGAACTGGGGCGTTACAGAAAAAACTCTTTATCGACAGCAAGCGTGTCGAGGGGACGAAGTATGCAGGTGCTGATCCGCTATTACGGTATCACCGTGCCTGTTATCAGACTTATGGCAGATTAGCTTCCCGGAGAAGCTGTGAAAACAGACAGTATGAACACCGTAAGCTCCAAAGTGATCACCATTCGCTCATGCATAGCTATGCAGCGAGTAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT -+ -11ABB8$$&BGB,'<90'%$%'4)=06()',$-/4-&&:2014,,&==;;97B333-/0*5+.*-001/2.0()%('&##$$$$&&799CC>>8=--80.)%))&/:<?GB?>98?>HBI;A>((<0)'+5'9./-3E=:A<@CC>D?8<;?,$./A,<77C:ADE:DC=;CLGA=;.42+$2(%-//.*7&?*)$$4(15.&&4;=9=BB@B=&&>2;=766->&*/.*8)021A>???9CA7,=5:D?IFEK@CBGB?LC?;@CB5<:,0++'#'$%*465-A@*&45.'5AB):9?>9B?>A9:,=<$6;;61;<-+=9><=>>7%"%+/21:7C??+DE2270C<;;?G?61887&*$*-)'%0-,/+-#,'117-'23*$'$#%%+&%%&($$((+0,%%1--02/-2:<+0@=3-3)),,,&).*&(((&0')+0(&($%&).+,:96FED7:87*&'=@E@<3;5D/00**,-5<@AG@=GF6+')&/*3.693.&'&%-$)0)2*++1854-(),.3..00/.54,($-9'5044748$)$)*)3475=:**@>.045&%/0/43//777:01'()/E91($22361001+)*22-7&&--$$)##&$$$$($/,+5<**''$%0500:4-88/08=<**#&&&$*%'.,--+)04>@@ADABLO56?J@+'62%$274=.;5-8&4;6=8.....12%#&-//(0%&%#$#$%(-122--*&&&-$&&)%%,4326$7;DDC@=<.(08;)(*(-1143((+1513=A<<>>,#$$%(&$%366;81516CD87,,)$2&.16:;02@C:6+$06;@AABA;:2-&#$'-$(*+6$%$&%%23.414/B0,&$'$$#$&.47;,00:7339$&$'33<@+'6 -@ce62bc1e-78e9-4bc7-9e1b-b8dd3604f2b6 -AAAGAGATGTTTTACCCCGGGGAAAATAGGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTACACTCTTCTTCATAAGCAGATGGTGATCACTTTGGGAGCTTACGGTCGTTCGCCACCGTCACATTTTCGACAGTTTTCTCTCCGGGAAGCCATCTCTGCCATAAGTCTGGATAACGGGGGTGGTGATACTCCGTAATAGCGATCAGCACCTCCGCATACTCCTGTCCCCGACAACGCGTCGATAAAGAGTTTTCTGTAACGCCCCAGAGATCTGCATAACTTCTTTCAGTACCGTCATCAGTCCGGTGAGTTAACTTTCTTACCGAGCTGCCGCCAAAATAAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTCGGTTCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACGGTAGCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCGTAAAAACATGGCTCCGTATCTGACGCTGGGTGTCGGGCAAAGCCCGATCGGCGAAGTGTAATGGCGTGTGCATGCGCGGCAACAATT -+ -1(%'18310;;D6//4-.$)//03+%#$&,%.02,)56,641+3?@:.(<<>?AA=:6:A5::;7:-3+.*%75679;>I<0,(())(')%8:556=<5+->>A9./1/)*>?BBB<<;()*''+/346789.1.17;$+8:AA789#?6:<*(**)*12668@:C.4?,@298AFACB?>C@EC=<87,'-),,.),$%&*#04.555/343034))&%66=B;:<;,549?2))&%'/0//(.%($(,,6?A@=9<39.($"%%'%%%(+$)%0)+')%&%$$%,#&#$$$$/%%++.#%%&&$$%#-++2'-$%'%%,-.-/ -@6c74468c-23ee-4c55-a905-4ac27419f7ca 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f4d56-6764-4256-b222-6960145f8306 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-GGAAAACAGGAAGGATGCATCAGGATCGTTTTCGAAACTAACATAATATATGAAGCAGATGGTGATCACTTCGGGAGCTTACGGTGTTCATACCGTCTGTTTCGACAGTTTCTCTCGAGGAAGCTAATCTGCCTAAGTCTGGATAACAGGGCACGGTGATACTCCGTAACGATCAGCACATCTTATACTCCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTCTGTAACGCCCCCAGTCCTCATAACTTCTTTCAGTACCCAAGTCATCAGTCAGTGAGTTAACTTTCTTACCGAGGAGCTGCCGCCCGTAAAGGCAGAGCAGTCTTGCGCATTCAGCTGCCCAGCCCGCTTTTTTTTTTTTTTTTCTGATTTCCTGGTCTTCTTTGCCGTCAGACGAACAGAGGGCAGCTAATGATAACCCGCCTGCGCGTATTACTTCACTTCGTTTTGTCATAAAA -+ -+-3>=:56.-%$#$%389@CA6.EG5((9CHG<1+)*))3556660.7448>8;3922*;=@./)%*9:5-$%'%"%&';@9@A;327.,0'(**,&$$#$&##'$$%4527874(2('&%&&(%)+).-9<>4)*4EC90<$$#%'& -@59335f9d-2638-4634-ba8f-e2f658dd126e -GTTCGTCTGACGGCGAAGAAGACCAGGAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTTACGGGCAGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCAGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCGGAGTGCTGATCGCTATTACGGAGTATCACCGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATCTTTGACGAGCTATTGATCCTGACATCTTCCTGTTTCCCGGGGTAAAACATCTCTTT -+ -AJGB>3@7MCG-3:''955,26,/)1//9E;B33=;3**7@9:8)'''/049(0DEFFDEH>IFB&*&.<=@6?AA;>=+'5/*8?B>AF28?664<98?DB>??@BAJ9/98=;GA?C@HH;9*-85<68=A@;;76A7:2222>BCB@=<044=>?;6E66;;>:1A16/98.&.-34;C>ECDF(DCB&&B8>>''(8@8:=<<>@:D3<=>*06)-0&&+&9CCE@B92;4;8715/628$'5:+..7;6%078::2=<2==>412,+)A6==>DE>98JK@@6/+6/4869;700((-3+(&$)%&$#$))346/0,+$(4;=9;$.,,9=?HD@<8>;CDC9<?@=>?9<;1<87477*.>AC=F;<3$$(57;F47==8=5CEJ@<8%5&:$%%%$)&->B=AB>@=+'5&&&+)&&?BDDJHF53<<;KIHFHE;2A,?=@BA549:7/+.@*:>$:?02-/((/3@69/64=?B?><8:176))1AABEA<@B=EA8'&5,6K>B84<>@FHKGE;553'0-@---,+3289=(:2=DGIG@BC=C;4C<=9<96966=C?21)*0;763$2/'(:?CCACDA?==@@EIIEG;A:)4;03>,9)2,':A?;==688?77C19=<<=-.?367'%:AD<:;7<7//-0.+8-.CD<>965=GH@DD?=<3-B10;<;;@??+877@>:/./0CA;.<&0,.&-0$,%''79FDE?8::29BD>>?4987FAA?>=82:&&/04990,1%&%,31,.275?5::=A)A>@..D9CA77657;B:G7BCB?@AFE7=B?@EB.3D><1-2.2'('+62>:+,+5;<18D<=@DK:BJ=85DAB=67=>B?BMC;:4.%'.$$&3--1,&(*0?>-/')+*./7CC3<2E6F,0C>@>879)%/$(&$6;4;==7443->0.0/2+/-*,-($"&(29::;<935521,=&&*,25:%;23.,89>8:933:8'.6>@@>8:??24/(;B??>BD/,)<89IB(.%,++,',.0)169>A&&*)*-'&&).$&&'.5=EA=924*%%$'0;&-4:1EGED95;?>966+;;?9)&/94+%-56:C<=GM@=<:;C2518*8&+-../4>A8B?;-1/4'4$$$ -@f4d1033e-fb7b-45f1-bfc0-752c8b7c7383 -CTTGCTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGATTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCACAAACTGACATATCAATGAAGAACAAAACCCTATTGATACTGACGATGACTGCTTCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCCGTGCATAATTGCACAAGAAACGCTGAACGCCCAGGTCTGACGCGCAGACACCGCAAAAGAGATGTTTTACCCAGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGAAGTTTTTTCTCTCCGGGAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAGCACACTCCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCACCGAGAGCTGCCGCCCGTAAAAACTGTCTCTTATACACATCTTGAGCCCACGAGACCAG -+ -%$$&25756F'8/=A@:CAC=?A=<<5,1))'%%13<43&2/-05223<>FCGGB1<181:=D=-?@A;''..+9.&(%%,9ABHEBAGGEAFIFEA<2(?*@@CDKLADG>D7@BB(31>:CF1DA44/)')'&&$-11.3((/(++4=66999::@F<;>C?>7;=CFC@9:C?<69-&9:;D2'%$$'''';;==C7?9:93*&0&&1)34.A4:@F=:;5%)'++0?@4C;,.>@6;+A=:4>=>??@:6*?B;@JNC?>=?9:*(8B:;8EB8FKAFGIIGF50/453/#%''&%$.,,,//417((%87055:8:3.'$)0'%)$&%)-+.)($.''@<;A9BD@8<@NHO,0'=9::CCIBG4;6CA?<22DA68>86<;544-%,4A<;8B@G6,&$$%)1IF>.178C5-,-,,6<:@?>>=8?3+/+.+355;7''=8.''441'$$:=8<935.4&$'09;=D=<;7988'*::;=:?@8:AFF?,49HLSGE?<+0;<@;B@>B;>6.73?.@CC<>B?@C>.2?3?9><9887A5(85263./<9:CHD=?789B;;9300'CAAA&9:DE=DEBGHB96-..;=??;<=@7225<==(:244,'&&145>5+/'4(%'%% -@ae0853da-5e92-45c3-b88b-20fed2a4964f -AAAGAGATGTTTTACCCCAGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCTTTGGGAGCTTACCAGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACGGGGGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCGCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCAGTCTCATAACTTCTTTCAGTACGATCATCAGTCAGTGAGTTAACT -+ -.($+)('7;JJE=;9;;,*??;IGH*&AIBJ@><53.).:0>CCAFAPLM84?7?@B0&,2<.58?;67=?D@C?JR=%:;BGZREC>&=>?@=ED@0/18<+9*,:/-8<;>?8:28=2066?F8893812+2,2(=@@88?@ -@c127e70a-405f-46c0-ae0b-e647ef99c3af -AGTTATGAGACTGGGAGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCAGAGGTGCTGATCGCTATTACGGAGTATCCTGCCGTGCCTATTATCCAGACTTATGGCAAGATTAAGCTTCCCGGAGAAAACTATCAAAACAGACGGTATGTTTTCACCATCCAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAAGAAAACGATCCTGACGCATCCTTCCTGTTTTCC -+ -''+039A>BD56<@D/9>FLGHAD?47;@@@BF=?@@?::8AB:<+-/:@:9;>1<574/.)3/-:?98IG2),(-888;CA0271=8./8////-2/430-,/0%%:-/=?IHA<,/0&('$$%()2113176')-+79>,&(%$$$'..,',')$&)&%.%%%%%%$%%##&)$''(+*()&,4587A@@@GJL;;))8719BDF844311:1//10)&'/00+<6=56-.:..7/.(-@?>AKH*. -@9a0e90b3-3c3e-4843-95cb-b1596828ed6f -AAAGAGATGTTTTACGGGAAAACAGGAAGGATGCGTCAGGATCGTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACCTGGTGTTCATACCGTCTGTTTTCGACAGTTTCTCTCCGGGGAAGCTAATCTGCCCGCCAAGTCTACGGATAACAGGGCACGGTGATACTCCGTAACGCGATCAACACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACACCCCCAGTCT -+ -BE1%7>?A=FFE7-5'.25855*%5410/:48:;5371>B85@9@=<836>;A648+,2/5+&@:05E<>A>;DDDBB@:765638DE)63$'73;<<<@8=39,9?IK4=5AMJPH<3+)'-.30FIGA0.701' -@162b5056-1cc5-40d8-a1de-6bebe548bc27 -TGTTTTACCCCGGGAAGCAGGAGAGGGATGCAATCTTTGCAGGATCGTTTTCCATTTTGCCCGCTAGCTATGCATGAAAGCGATGGTGTGATCACCGGGGAGCTTACGGTGTTGTCCACCGTCTGTTTCGACAAGTTTTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAGCAGGGCACAGGTGATACCGGCAGCGATCGCTTCCTCCACGCCTCCTGTCCCCGACACGCGCCGTCGATGAAGTTTTTTCTG -+ -%,68@8/-778/-((*),*;0/$&36882,/#$%$%)00-,6;<9?@JCDE34'())(&$''#$,,(1+?=95*$' -@c506ed82-9194-4814-9a9d-7532715b5f51 -AAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGGAGTATGCCCGGAGGTGCTGATCGCTATTACGGAGTATC -+ -(+;;<;.BDGD4:E?>?B<=??@7=@69885'8&.=>B?C77=A?>?ABCEBID71031;15IE@F9>,@=DKJ?1@CIG>99@=B>:BC:4@?=-%8?28;.:3=87;< -@aba91300-4618-4b54-beb5-01aefe1e0af8 -CGCTATTACGAAGGAGTATCACCGTGCCTGTTATCAGACTTATGGCAAGATTAGCTTCCGGAGAAAAAACTGTCGAAAACAGACGGTATGAACACCGTAAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTTCCCCGGGGTAAAACATCTCTTT -+ -42@A=BA<(/%$&*#&8-)<353-B3=<>>A@*%?458331.2'+3#%)+0.*4899%+/4-///((*)'()*337731,)0,>)1420))/==5678785(10)0-12-/=977:<75&99,$%):@B;:9:(),),(8221*:;00:2144KH=A6:**0$&%4355:;?C?8:D?=@C@86@;>A??64 -@e3986483-5f5e-480a-81bc-cfaac9c8678e -GCTATTACGAATTATCCACCGTGCCTATTATCAGACTTATGGCAGATTGGCTTTGGAGAGAAAACTGTCGAAAACCAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATACGGCGGAGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCGGGGTAAAACATCTCTTT -+ -(?A@=CE-3()(49))6,69>H>::/(79,%3(0:&&%*3)-0/23-5$)**+&6;<),%:CC=5?7562**'%%61>=?:;FDF@?:4>56>?3/(<;)0*02/36<<;AAABCDFE::JIF<9;5:4<:?>@-)'3'.1$&&$&,;:00C?'4=>((,@D9H?@B<;=HG=@=F<;CB>D?= -@7a97d860-e33a-4e27-b5be-c4754a2eb907 -ATTACGAAGTATCACGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCAAAGTGATCACCATTCGCTTTCATGCGCCTTGGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGAAGGGTAAAACATCTCTTT -+ -?>A?'-$%+?'%8$03F;;;=8*57>((?3:E?E?65%,0,.,B>77?AA69?<>??:78:@97424%%$'%')460((8,:;1/4////@;5;?@//5896:.+?:@KEA@LD=C22.+01849?D<>@;A=C29;5>8832,>>459;+;;)-(+$%$*77;6CAABDB?-0*+,(&$+&**8:85=??@))?%.7+*4/+(*.'($#%,,++4;EBB:B>78=8<=@GBDCGB@5;A+1<$6:EGDAG;:>>@@?H -@749ba682-4ec2-4367-8bb3-51878f06992d -CCGGGAAAGCGGAAGGATCGTCAGGATCGTTGCTACAGCTCTGCTACATATGCATGAAAGCGAATGGTGATGCTTTGGGACTTTACGGTGTTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCAGGGAAACTAATCTGCCAGCAAGTCTGGATAACAGGG -+ -#$$(+('&%,$)5;:8/&(,121165++.-/$$(%)(%#%'#$$$$&&%$%(3/1<222(666:=8<47/&$&)),&'&',-/.39=B>B?=-89;=>=;;;335686E;=9499=PA@-8<%/'/*+,)$77=7/-5//.-&(()**7',./102,&,&' -@3d6bdcab-ef5c-4ff8-a928-23066fb4e887 -CTGTTATCAGACTTATGGCAGATTAGCTTCCCGGAGAAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAAGTGATCACCATTCATCATGCATAGCTATGCGGGCAGACTGCGAAAACGATCCTGACTCCTTCCTGTTTTCCGGGGTAAAACATCTCTTT -+ -12551)$>,,/,,,AE??>==?6/.'''-8>B03<+,,-=CA@;;/09:6470999-%171+98==8<;6#'36;AC;7:689<<89%*./(&$++$-+--<-;=>55:4;*%&%*%/454@CAHA/318?G?4599=9?DEA@?E -@0b41ea60-ea37-43ef-a912-260c4d33a356 -CTGTTATCCAGACTTATGGCAGATTAGCTTCCGGAGAAAACTGCTTCGAAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCGCTATGCAGCGAGCTGAAAACGATCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT -+ -=B>B3+++7-2-))%&.%,3**749689:=1B0.3&)(-'$$%#%(*(((('$,)+(/+,,/48:>;62+7:)*.<;9>@DE75@?;>?::>-043+).2?;<(&551.;><:8G@6E@<6@7<6@1CE78BDB>?=?57I@'-G3;@B=>@F@?8794- -@cd8d2944-a807-434b-92d5-bfa925697c85 -GTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGGCATGAAAACAGACAGGTATGAACACCGTAAACTCGGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCTCCTTCCTGTTTTCCGGGGTAAAACATCTCTTT -+ -8?>>%%06/B@FEFG7=854742')9<=+3B9:<98%;<>3..-(&$*/13,*;8;1+&59ADB55<94<<:;99(&)+#&62-'('668:7855;=C><24B=>==>;B<:30=;=1;9575IF9A=E55<:@?GC;77=069<=25152/56)/,45?>@BE162;>:9DCE -@a492dd23-2c03-4d9b-a606-dee7268bd4fa -AAAGAGATGTTTTTGCGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCGCTATAGCTATGCATGAAAGCGAATGGTGATCCTTTGGGAGCTTACGGTGTTCATGCCAATCTGTTTTCGACAGTTTCTCTCCGAGGAAGCTAATCTGCCGCAAGTCTAGTTAAC -+ -F:&-/77;:@??=8%%$(#'+()%+9.99AB?==<<7/;;4/;;B>?-+(*2%%&0-1-=5;99GD=88>9>??=IC2:B?:%%*#*-&.1**,--;A::8BID?4&&%8'(B64>:;31&*,(5('7A04.>@CC;AA7%1-1%&-/5'%*%-+,/ -@4a58265a-1d25-47a1-b851-e7687203734f -GGGAAACCCAGGAGGATCGTCAGGATCGTTTTTTCAGCTCGCTGCTATGTATGCGCTGAAAGCGAATGGTGATCACTTTGGGGAGCTTACGGTGTTCATACTGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAAC -+ -)**%&&%5'%)*$..5%$$,70?B?:>?GBLB<0))%&'-78>.11/$$+($&$&%***2),=88=@,1A=:3<25;<959E;.9?BB*A=B>B9?LL;AA74C>CNEDFC=4=?@BB9@>>2-A14:C;..5 -@f9a56724-1fa4-4807-bacc-f0a85587afd7 -GAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTTTCATGCATAGCTATGCAGCGACTGGCGATCCTGACGCATCTTCTGTTTTCC -+ -414===BA;3-.21$+&')'%-20-,((+6:57(*+,139@@?A534546/24022**)$$$#&(--++-7<+6*.*(())(,-03<:(, -@e525f31a-e4d6-4fe6-a703-7038efa2f178 -GCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTCCCGGGTAAAACATCTCTTT -+ -;B@E::0+5511=2122@>52((''*HECB@C@?KHI -@eeef3ccf-2188-4382-8399-a9442bbbf40a -GCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT -+ -@=:3335937))43378KC?CKMEH?BC55=4C>?KDFCLC4@G363877800+7<=;3;;> diff -r ce2bf68a260d -r 148f32860445 test-data/bwa-mem-mt-genome.fa.fai --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/bwa-mem-mt-genome.fa.fai Tue Sep 01 03:06:38 2020 -0400 @@ -0,0 +1,1 @@ +gi|251831106|ref|NC_012920.1| 16569 31 70 71 diff -r ce2bf68a260d -r 148f32860445 test-data/medaka_test.bam Binary file test-data/medaka_test.bam has changed diff -r ce2bf68a260d -r 148f32860445 test-data/medaka_test.bam.bai Binary file test-data/medaka_test.bam.bai has changed diff -r ce2bf68a260d -r 148f32860445 test-data/medaka_test.hdf Binary file test-data/medaka_test.hdf has changed diff -r ce2bf68a260d -r 148f32860445 test-data/ref.fasta --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/ref.fasta Tue Sep 01 03:06:38 2020 -0400 @@ -0,0 +1,2 @@ +>NC_045512.2 +ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACC diff -r ce2bf68a260d -r 148f32860445 test-data/ref.fasta.fai --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/ref.fasta.fai Tue Sep 01 03:06:38 2020 -0400 @@ -0,0 +1,1 @@ +NC_045512.2 2940 13 2940 2941 diff -r ce2bf68a260d -r 148f32860445 test-data/variants.vcf.gz Binary file test-data/variants.vcf.gz has changed