# HG changeset patch # User iuc # Date 1590255468 14400 # Node ID 711d4deb7bdff13e15e71f58b2722b28d3e3909c "planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/medaka commit 1b97fa7a21a2c85bf4891aed1b7df92685b346c3" diff -r 000000000000 -r 711d4deb7bdf all_fasta.loc.sample --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/all_fasta.loc.sample Sat May 23 13:37:48 2020 -0400 @@ -0,0 +1,18 @@ +#This file lists the locations and dbkeys of all the fasta files +#under the "genome" directory (a directory that contains a directory +#for each build). The script extract_fasta.py will generate the file +#all_fasta.loc. This file has the format (white space characters are +#TAB characters): +# +# +# +#So, all_fasta.loc could look something like this: +# +#apiMel3 apiMel3 Honeybee (Apis mellifera): apiMel3 /path/to/genome/apiMel3/apiMel3.fa +#hg19canon hg19 Human (Homo sapiens): hg19 Canonical /path/to/genome/hg19/hg19canon.fa +#hg19full hg19 Human (Homo sapiens): hg19 Full /path/to/genome/hg19/hg19full.fa +# +#Your all_fasta.loc file should contain an entry for each individual +#fasta file. So there will be multiple fasta files for each build, +#such as with hg19 above. +# diff -r 000000000000 -r 711d4deb7bdf macros.xml --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/macros.xml Sat May 23 13:37:48 2020 -0400 @@ -0,0 +1,104 @@ + + + 1.0.1 + 18.01 + + + medaka + + + + medaka --version + + + + @online{medaka, + author = {Oxford Nanopore Technologies Ltd.}, + title = {medaka}, + year = 2020, + url = {https://github.com/nanoporetech/medaka}, + urldate = {2020-05-06} + } + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + `_ and `github `_. + ]]> + diff -r 000000000000 -r 711d4deb7bdf medaka_variant.xml --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/medaka_variant.xml Sat May 23 13:37:48 2020 -0400 @@ -0,0 +1,159 @@ + + via neural networks + + macros.xml + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 'round_1_vcf' in out + + + + 'round_0_hap_mixed_probs_hdf' in out + + + 'round_0_hap_mixed_phased_bam' in out + + + 'round_0_hap_mixed_phased_vcf' in out + + + 'round_0_hap_mixed_unphased_vcf' in out + + + + 'round_1_hap_1_vcf' in out + + + 'round_1_hap_1_probs_hdf' in out + + + 'round_1_hap_2_vcf' in out + + + 'round_1_hap_2_probs_hdf' in out + + + 'round_1_unfiltered_vcf' in out + + + 'log' in out + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + \ No newline at end of file diff -r 000000000000 -r 711d4deb7bdf test-data/alignment.bam Binary file test-data/alignment.bam has changed diff -r 000000000000 -r 711d4deb7bdf test-data/all_fasta.loc --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/all_fasta.loc Sat May 23 13:37:48 2020 -0400 @@ -0,0 +1,1 @@ +bwa-mem-mt-genome bwa-mem-mt-genome bwa-mem-mt-genome ${__HERE__}/bwa-mem-mt-genome.fa \ No newline at end of file diff -r 000000000000 -r 711d4deb7bdf test-data/assembly.fasta --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/assembly.fasta Sat May 23 13:37:48 2020 -0400 @@ -0,0 +1,56 @@ +>4 length=3792 depth=114.52x circular=true +TTGCGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTGCGTACAATTACAGCATTATGTTAAA +TTTTATAATTGTCTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAAT +TCTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAG +AATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTA +ATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTATATATCTA +AACACCTCTTTCTTACACGCGTGAGCAATGATTAGATCTTCTATTGCGCCATTCTTGTTTTTTCCTGGCA +TGATAAAGAAAGATATTTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGGTGATGAAATGTT +AAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGATTCGTCGGCATCGATGATTAAG +AATATACTTTCTTTTTCATTAAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTTAGTTTTGTCT +TTCCATTTATTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAA +ATCATCATCACCCTCAACGAAAATGACTTTTTTATAATCATTTATTTTTCTCGGTTTCATTTATCTCACC +TCCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATT +CCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTTCATCTAATTCGTTTATCGCACATAT +TACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTTGCTGCTTCTATCAAAGCGTTG +ATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTT +GAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAA +TTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATT +CTATTATCTATTCTTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTTTGTGTTAGTAGTTTTGATACGT +TTTTTATCGTTGCTTCTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAG +CTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATC +AATTCTTCTGGGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCCCTTTT +CCTGAGAGCCGAGGGTTTGTCGCAATGGAGGGGTGTTTGATAATATTGACTCAACATTGAGGGACACGCT +TGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTT +ATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAA +GAGATGCTTCATTTCTAAAGCTTTTTACTTTTAACAGAGCTGCTGGGTTTTTTACGTCATAAAATGAAAA +TATCGCGTCTAATATCGATGTTTTCCCAAAGTTGTTTTTTCCGGATATTACATTAAGTGTTTTTAGTTGT +TTGAGAGTTATGCTCTCGAAACACTTAAAATTTTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTC +TCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTC +TAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTT +TCTTCTTGTGATTATTGTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAAACCACCTGGGGAGGTG +GTTTGATCGAAGGTTAAGTCAGTTGGGGAACTGCTTAACCAGGTAACTGTCTTGTGCGAGACGAGTCACC +AAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAAGTACTCTCTTGAACCTCTCGCACATC +GACTTTTACCAATGGCTGCTGCCAGTGGCGCTTTGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTT +ACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACC +TACACCGAACCGAGATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGG +ACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACACCTG +GTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTTGTGATGCTCGTCAGGG +GGGCGGAGCCTATGGAAAAACGCCTGCGGCGCTGGCTTCCTCCGGTGCTTTGCTTTTTGCTCACATGTTC +TTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGAGTGAGCTGACACCGCTCGCC +GCAGTCGAACGACCGAGCGTAGCGAGTCAGTGAGCGAGGAAGCGGAAGAGCGCCTTATGTGACATTTTCT +CCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAA +AGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATGGCAGCCTGTTC +GTCAGCATCGGGTGCGTCCAGTTTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTG +AGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTGATT +ATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGGCATTTCT +GTCAGACAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACA +GGATGTGCAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAGGGCTTTGCCCCGA +CACCCATGTCAGATACGGAGCCATGTTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCGGGCTAT +CAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAG +ACCGTTTCCGGTTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTAC +TGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAG +GGAGTATGCGGAGGTGCTGATCGCTATTACGGAGTATCACCGTGCCCTGTTATCCAGACTTATGGCAGAT +TAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCAT +TCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTA +AAACATCTCTTT \ No newline at end of file diff -r 000000000000 -r 711d4deb7bdf test-data/basecalls.fastq --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/basecalls.fastq Sat May 23 13:37:48 2020 -0400 @@ -0,0 +1,1016 @@ +@215f1e0c-27d1-4446-bca5-cb0fd6a8c054 +TTGCAGTATCTGCGTCAGAATCGCATTCCAGCCGCAGGTGTTCAGCGGTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTAGTCATTGCGCTATGATTTGTAGGTGGAGTTGTTTCATATTTTGATATAAATTCTTTTATCTCACCAAACAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATTACCTATTCTAGAATCTGATTCCTTGTACAACTAAGGTAAACTTGAACTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATGATGTAGGATCTAGGATATATCTATAATAATAATTCTTGTTCTTTTTTTATTTTATTGAATATGAATCAATACCTGTCTAAGCACACCTCTTTCTTACGCGTGAGCAATGGTTAGATGGATCTTCTGGCGGCCTTGCGCCATTCCTGTTTGTTC ++ +?B4-)&'%:883110,;*-$/+%)(.(($$#%&$$#%14+6-/=1@5@A>GE@F@?AA13EJHTIDHBDAJB@BOM908=B;=>49/(?>>?>?@?(004?C57/9DEEE@@@C?=>=<912+,*'1/1396;78+&$&,15(85::C@>BA>9(,BCB=(4<.=91<4@ADC9:AC$=9>555=3412;6;+=>?@>2$%+839@BH=CAOHFCI<.98<-0/*$%)0**()(')&$)$474)+/,'267432&&'&''''$%&'*')>?C3=;467===95489G:./5229,$$&$(&&$%%(''')+8%/0%.-%0$')&'*=566(-(685''57./4%)44+/*$$$'42:;6($$##$$$'-0(%67112$$'$())'7;: +@baf1c4f7-8f02-4c92-be5f-0431ca399c18 +GGTATTACTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGTCGTCGGCAGCGTCAGATGTGTATAAGAGACAGCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACAGGGGAGTTCGTGCACACAGCCCGAAGCTTGGAGCGAACGACCTACGCGAACCGAGATACCTACAGCGTGAGCTATGAAAGCGCCACGCTTCCCGAAGGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCGGGGGAAACACACCTGGTATCTTTTTATAGTCCTGTCCGGGTTTCGCCACCTCTGGCAGGCGTCGATTTTTGTGATGCTCGTCAGAGCGGAATTTATGGAAACGCCTGCGGCGCTGGCTTCCTCCGATGCTGCTTTTTGCTCACATATTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTGCAGGTGAGCTGACACGCTCGCCGCAGTCGAACGACCGAGAGCGTAGCGAGTCAGTGAGCGAGGAAGCGGAAGAGCGCCTATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCTGAGCGTTATCTCTCTGTGCTATTTTTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCGGGTGCGTCCAGTTTTCGAGCAGCATTCAGGCTCTGACTTTTATGAATCCCGCCATGTTGGTACGGCTTTTCTTTCTTGTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTGTGTATGATTATATCGCGTACCACTTTTCGGCTGTTTGCTGCCGTTATTCTGCGCCGCTTGGCTTTTTGACGGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTACAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAGGAGCTTTGCCCCGACACCCATGTCCAGATACGGAGCCATGTTTTGCTGACAAAACGAAGTGGAAGTAATACGCGCAGGCGGGCTATCAGTCCCCTGTTCGTCTGACGGCAGAGAGAAGACCAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCGGTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACCCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGAGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCGTTTGATCGCTATTACGGGTATCACGTGCCCTGTTATCAGACTTATGGCAGATTGGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAACATCTTTTTTGCAGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCAGTGCGTACAATTACAGCATTATGTTAAATTTTATAGTGTCTTTAGTCATTTGCGCTATGATTTTGTAGGTGGAGTTGCTTCATATTTTTGATATAAAGTTCTTTTCCCATCTGCTAGAGCAGTCATCGTCAGTATCAATGGTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGGTCCTTATTACAACTAAGGTAAACTTGAACTTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATGTAATAATAGATTCTTGTTCTTTTTTATTTTATTGAATAGATCGTCTATATATCTAAACACCTCTTTCTTACACGCGTGAGCAATAGTTGGAGTCTTCTATTGCGCCATTCTTGTTTTTCCTGGCATGATAAAGAAGATATTTTTGTGCTTCCCGTTAATGGCTATTTCATTGTGCGAGCTTGGTGATAAATGTTAAGCTCATTTAATGTTGAAATTATCTGATCTTTCCGTGTCAGAAAAACGATTCCGTCGGCATCGATGATTAAGAATATACTTTCTTTTCCATTAAAGACTCTATGCTTTTAAATGCTCTAAGGGTTTGTTTTAGTTTGTCTTTCCATTTTATTTTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTTAGGAAGTGAAAATCATCATCACCCTCAACAAAAAATGACTTTTTTATAATCATTTATTTTCTCGGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAGGAAAATCATCCATGTTAAATTGCATTGCTGTAGGTTTTGGGAATTGCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTCTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTGTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCCATTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAACTAAGATTGAGCTAATGAAAGACAGCGCTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCCTATATCTAAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTTCATCTTTCTTTTGTGTTAGTAGTTTGACCGTTTTTATCGTTGCTTCTTTGTTTATGCTTCTTGATGTGGTTATTACCGCGCTGCGGTTTTGAACTCATATAGCTTACACACTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCGTTAAAACATTCCCCTTTTCCTGAGAATAGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGGGGACACTGGCAGTTCACTTTATTGTTTATCATCGTTGAGTATTTTGTCATTACTTCAGCCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAGAGATGCTTCATTTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAGAAATATCGCGTCTAATATCGATGTTTTTTACCAGTTGTTTTCGGATATTACATTCAAGTGTTTTTAGTTGTTTGAAGTTATGCTCTCGAAACGCTAAAAAATTTTAAGTGGATATCTTTTATCATGTTTAAACTTGCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCTATGCCACTGTCTCTTTTCTAGAAGTATAATCAAAATAATATTACTTTATAGTCCTGTTTGGATTGATTTTAACAGTTTGTCGGAGTTTCTTCTTGTGATTATTGTGT ++ 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++ 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++ 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++ 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++ 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++ 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+;;?22%%8@OM@??@><=:EEE9=CB5:1-9)1$#&'%1%'0&(,-&(?==?9)*<:>/'6.''+%&65/+,(,.*/<<85).7@889%(%%$'#('(0+($*''%(&'$2459@-%9$),3'*&%'%*.33/,/&,$($,.$&'().&3*+,2(%&(%9:?=<8=:25:C?'C<;/-/./9-<3<;87;87';454CFAI@++1448$/;93+;<912=,0B??@-43:82,DFE;1>),--,//8B05?DOC-&4(+,8454@??@15##$/1/04++0/@?EE>39&(9((1=BD@=?>=/4//$/1==BBAA@FD>8.*,-57=*,>2,7&&.&&$&'%'$)''$$%223')+(79<63:A7:947*&'&$)$&$)&&2:1+523.2'&&(-)++-8C=@DC>CLCQFFECA0@3<@EDCA9FEE=<<6<:))+))8;;@B9>;?5> +@3903ad0d-208b-48d9-b2eb-010c5552927d +GTTGCTTTGATTAGTTGTATTCTTCTATATCACGCGCGCATGTCTGGCGACTGGAGATGTATAAGAACAGGACGAGCATCACAAAATTGAAATACTCAAATCAGTGGTGGCAGAAACCCGACAGGACTATAAAGATACCAGACGTTTCCCCTGAGTGTATCTTCTCCCTCGTGCGCTCTCCTGTTCCCGCCTTTCGGTTTACCGGTGTCATTCCGCGCAACATGGCCGCGTTTATCTCATTTCCACGCGCCTGGCACTCGGATGAGCAGTTCGCTCCAAGCTGGACTGTATGCGACCCCCCGTTAGTCCGACTACCACGCCAATTTCGGCAACTATCTTCTTGATTCAATCCGAAAAGAGCACGACAACACGCCATTGGCGGTAGCCACTGGTAACTAGATTCACGGAGTGAGATTGCAGAACTTACACAAGAGTTCTTGATAGCAGCCTGACTACGGCTAAACTGAAAAAACAAGTTTTGAGTACGCTCCGTGTAAGCCAATGAGTTACCTGGTTCAACGAGTTCCCCAACTCATTGAACCTTTAGCTCGCCTCCCAGGCGGTTTTTTCATCCCCAATTAGCCGGTAATCCGCGCCAAGAAAACGATTCAGAGATTACAAAACGATAAATGCATCGCACCAATCGTTCAAAAAGCAAAAAACGATCAAAGCTCGCTGACATACAAAAAATTTATATAATCAGGCTTCCGGAATTATCTATTAGCCCGTACAATAATTGGAAATCTGCCTGTTTTTAATACAGTGACAACTACGACCTACAGAGGTATGCGTATGAACGCTATTAATCGACGACTTACAAGTAAGGAGGTGCTAATGAAGAGAAATCGTATATGTTGGCGGTGCCGAAAAGACCTAAAAAATCATTCACAAAAGCCATGTTTGATGAGGTCTTGGTAGAGATAGTCCGCTTACAGTGCGGAATTCAACCTATCAGAAAAATAAAACAATGAACGGCCTCAGAAGGGTCATGGAATGGACAAAAAATGGAAAGCCAGCATACAGACTGGTTATGTAGTAGGAAGAGCATTTTCATACTACACGCTTTCAAAAACATCTGATGGGACCCAAAATCGAAGAGGAAATCAAAAGAACGATATAACAAATATCAAAAATCGTGTAAAAAACAAAAAGGCAAACAGTGGTCACACCACTGCTTTTTACTTTAACATCAATAGGGCTTTCTTTATCTACGGCCGAAAGACACATCATAACAAAACCCCTATTCTGCAAAGCATTTCTAAAGATATCTTTTATTTACAACACAGTGTGTGTTTCATTTGGCTATCTTCTGATAGGTTGAATTCCGCACTGTAAGCGGACTATCTCTACAAGACCTCATAAACATGGCTTTTGTGAATGATTTTTAGGGTCTTTTCAGCACCACCAACTTCTTTCATTAGCACCTCCTTACTTGTGTCGTCATTACACCTACCTCAGCAGAGTCAGCTATAAAGCCTCTGAGTGCTGATATGACCTCTCTCTCCGAGCCCACGAGACACGCGCGCGTAGTAGAGCAATATGGCAAAAAAAAAAAAATCGGTGTGCTTCCGTTCCGGTTACGTATTGCTCACGCTGACGTGTGTTCGTCGGCAGCGTTTGAGATTGGTAACATAAGAGACAGGCTTCGAGGATTTCGTTGGAGTTCAGGGTAAAACCGCGTGGGGTACCTTCGCCAGGTTACGGCCCACGAACTGTTCGCGGACTTCATCGCCCGGGTAAGCCGAACCGATTTCGTGCTTGATACGTTCTGCGGTGGCTTCACCGATCAGGGAGGCGCCGTATTACGACGCATGGTTGATGACGCTTTGTCGAAGCGATCGCCACCAAGCCGCGCGCGGAGAGGAGTAAACCACGCCGTTCAAGGAGATAACAGCAACTTCAGTGGTACCTACCGATATCAACCACCATAGAACCGGTCGCTTCCAGAAACCAGAAGCAGGCCAGCACCAATTGCGGCAGCCATCGGTTCTTCAATCAGGAAGACTTCACCCGGGCACCAGCGCCTGCGCCAGGATTCACGAATTGCGCGGCGTTCAACCTGGGTCGCGCCAACCGGTGTTGCACAAAACCAGAACGCGCGGGCTTGGACGCATAAAGCTGTTGCTGTGCACTTGTTTGATGAAGTGCTGGGCATTTTCAGTCACGAAGAAGTCGGCGATAACGCCGTCATTGGGCGAATGGCGGCAATATTGCCCGGCGTACGGCCAGCATCTGCTTCGCGTCATGACCTACTGCAGCTACGCTTTCGGTGAACCGGCACGATCCTGACGAATGGCCACCTGGAAGGCTCATTCAATGCGATGCCTTGTCCTTTTGCGCTGATGGACATTCGCAGTACCCAGGTCAATGGACAAGTCATTGGAAAAACATACCACAGAAATTTTTCAACATACTAAGGGATAATCCTGAAAGCTGGGGCGGAAAGAAAATCCGCTTACTTTACCAATACACGCAGCAGCAGAGGCGCAAAAATCATCACTACGGTGAAAATTAGATTGCGAGAGTTCGTTTCCCTTTGTTACAATCTGCCTGAGTCCAGAAAGGCTTAATGCATCAACAGCATTCCTCGCCTGTTTGCAACCGCGTGAGTCATTCATCTGCATATGTGTGCAACAATCTGGCGAGCAGACAAGCACACTCCCGTGAGGTCGCAGCGCGCGTTATTCTACGTGAAAACAGATTAAACGGCAGGTTAAACCGAGTATCTTTGGCAGATATTTTTTCACGTTGGTATCAAACGGCTGTGAGGACGCGAAAAAAATCCCCTTGCCCGCACAGCAACACCGCGCTGGATCAGGTCTACCCTCGCTTTAAAGACGCACACCAGTGGCGTAAACTTGGGTGCTGGTCCCGGAGCAGGCTTCCACCAGGCTTTGAGAACCAGCAGCTGGTTCTCCGTTCTTCTCAATGTTTCTGACCAGCGGATGGAGCTTGAGTAACTCAACATTAAGTTGCTTTGATCAACTGGTGCTTACCAGCGTCAAACCAGCCTGGTTGACGGCTACCCCATCACCCCTAAAGCATTCACTAAACGAATAACGGGTTGTAAACGCGACTGATATGTTGACCTACATCGGCCTCTGCAAATTCAATAATTATGCGTTTCGTTGTGATTTTCACATTGCATTAACGTATCGCGCAGCCAACGCTGAAAAACGCAGGCGAATCAGCGACTCAACGGTAACCTGAATCGCCAGATTTTCCCTCCAGCCAGTAACGCAATAGTGAATGAATGGCTGATTTCGAACGGTCATACCTCTTCCCGATAAAATAAACTACCGAGACCATTCGGCATGCTCTCCGCCGAGCTAACCTACTTCATTACCATGAAGATGCGGCACATAGGAGTTCGCGATGTTGAACCTGACCTTCGCGAGTAACCGCCGGTTTTTGATAAAGGCGCGGGCCGCCGCGACTGAGCATTTGCTCTCGATAAGCGTACCAGCGAACGCTACACGTCCTTTTTCAGGCAACGAGTCATCGTAAATAGCCTTCATTGCCGCCCTGCAACGCATTACGCCGTGGCAGACTCTGCATGTTCCATTACCGCAACCGGTATCTGACCGCCGCAGGCGCAGATTTTTGTGTGGATCATATCGTCGCGATCGAGCATTTTATTGTTCGGCAAGGTATCGACGGCTTTGATTAACTGACCGGCGATGCTCTCTCTTTTAACGTCCGGTGCGGTAACAGCGCAGCAAAATCACTGCGGTGGTAACGCGCCAGCAGTGCGCCAGGAGAGTAGCGCATCATAATGTCGGTGGCAGATTCGTCAAGTGAAGAACTGTTGCTTCCCAGCCTGGCTATTTTTAGTATCAGCTCAACATATTGAAATCCGGCAGACGAAAGATCATCATCACGATCCCGTGGGTACCTACTTTCTCCTGATCTTCCAGTAACGTTGCTAACTGATTATCGAAAGAGTCGGTTTATTGAGGCCGGTTTCACACCCTGGGCGGCATAAAACGGATCAGCGTATCAAGACTACAGCCGTGTTGTTCGCGTGCGTTCTGAGCTTCACGAAGCAGCGTATCTAGCGCACTGCTGTGCTGGGCGGCCATTCGCATAGATGGTTCCCAACACGTGAAACCCGCTCACCGTTTAAGATACGATAGCGGTTTCCAGCGTTCTTGCCCGGCAAGTTTGCCGTTAACCAGCGTACCGCCAGAACATAACAATGATAAAGCCAATCGCCCCCGTGAGCGGCGCGGTAGTCATTAAAGAATGGAAATAGTTGCCGCTCGGATCTGATAAAATAGACGCAGCGACATCCCCGGATGCTTTATCAACGGAACACTCAGTTCGCGAAACAGATCGCTGGAGCCAACCGGACGATAACTACCATTTCTGGCCGGGGTATAAACCTGTTTATCACCATGGAGCAGGTCTACACAGATGATATCTGCCGACATCGATATTCGGTAATTTGTGGCCTTAATGTGCTGAAGTCATTCGGCTTCGGTGGGTATCAATCGCCGTGCGCCACCACCTGAACGCGATGGCTAAACTTATACTGAATTGCGTTGGCAAAGCTTAGCGAATAGCCCAGCAAAGTCACAAAAATTGTTCGCCCGGTGAGCAGCGTAACAAAGGCCGAGAACTTCGTCGTTAATCTCATCGCTTGTGTTAACTCCGGTAGCAGTGAGGAAGCGGGCATACTAACTAAATCAGTTTATCTCGCAATTTATTGCGCTTCATCAACTTTGCTTTTCCATTGTAGTATAGTCTTCAGAAATTGTTTTCAATCCATCATGTACATGAGGACCACTTATATACAGGCGTTACTTTTAGAACAGCAGGTTGGCAAAACTCTCGCATCGGTACAGACACTTGACAGAGAGTCCGCTGCCGGAGCGATGTCACGGTTGATGTTCACTGGTCAGGCCTGGACTATAAAGATGCGCTGGCGATTACCGGTAAGGAAAATCGTCGTAATTTTCCGGTAAGTTCTGGGATCGATTTTGCAGGCTTTGTACGCACACCAGCGAAGATCCGCGTTTTCATGCCGGTCAGGAGGTGTTACTCACTGGCTGGGGCGTTGGTGAAAACCACTGGGTGGGCTGGCGGAGCAGGCGCGAGTGAAAATGACTGGCTGGTTGCACCATGCCGCAAAGTGGACGTAAAGCAATGATTATCGGTACTGCCGGTTTACCGCCATGCTGTGTGTGATGGCGCTGGAAGATGCCGGTGTTCGCCCGCAGGACAGGAGATTGTCGTGACGGGTGCCAGTGGTGAAAAATTGGCGGTACGCGTGGCGCTGCTGCATAAGTTGGGTTATCAGGTCGTTGCGTTCCGGAAATTCGCATGCCGAATATCTGAAAGTTTAGGTGCCGGTGTCGTCTCCCTCGTGATGGGGTTTGCCGAATCCGTCCTCTGGAGAAAAACAAGTCTGGCTGGGGCAATTGACACTGTTGGCGACAAAGTGCTGGCAAAAGTGCTGGCGCAAATGAATTACGGCGGCTGCGTGGCGGCCTGTGGTCTGGCGGGTGGTTTACTCTGCCAACCACGGTCATGCCATTTATTCTGCGTAATGTCCGTTTGCAAGGGTGGATTCAGTAGCTGACGCCACCAGGGCGCGCGCACAAACCACAGCGGCGGCGATGCCGATTGCCGGAATCATTCCAACACCCGGGCGGCAAAGAAGAATATCTCTGTCAGAGGCACCGAACTTTGCCGAGGCCATCATTAATAACCAGATCCAGGGTCGCACGCTGTTGAAGGTTAACTAACCGTGACCCCAGCAAGGAATAATAGCAAGAGAACTCATTTTGACATCATTATTCAATCGGTTAACGGGAAAAGCGGTTGGCGGGACAACTCGTCGAACACCTTGGTCAGGAAGTTGTACAACATCATCCAAACTGGAAAGTCATGATTTCGACTGACCACAAATTGGTACGCATTGATACTCCTCTAAACAGCCATTATTGATATGCCTCCGTCGCCTGTTAGGTTTATGGTGCTTTGCCTGAGCGACACTACGCCAACCTGTTACTGATTTCTGGTCCATGGGGTGGATAATCTGATTTTATTTGACTACAAATTAACCACTCCGAACTATTTAATGCTGAGAATTGTCAGTGGTTGATTTTGCGTGCTTTAGCATTCACATCTATCAGACGATGCAGTGAAAATTGGGTAATCCCCAGCAACCACGCTGCGTAGCTGTCGTCTATCTTTGTCGCGATCACAAAAACCCTACATTATTTGTGGTCTGTGAAGATTATCACCATTGCAGCCCCTCATCTTCGCAGGGCTGGCTTTCAGCTTTTTCACCTTACGTTATAAAGTTCCGTCGATGATGGCGCTAATTTCGTGGTGTGCAGCTTGTTGCAAAATACACGGTGTTGAAGGTTATTTACGTAGTAGCTGTTGATTATCTTCCCTGATAAGACCAGTATTTAGCTGCCAATTGCTACGAAATCGTTATAATGTGCGACCTCGTCCTCCTGACGCAGTTTTGCGCTGCGGAAAAGGTGACATTGGCGCAACAGAAGGTATATTTGTTTTTTCGGAGGATAGCAGCAGATCGCTGCACAATGTCCATCAAGTCTAACATTGACCTCTGGGGCAAAATAGACCGGCGTCCCGGCCTGCTGGAATTTATAGCCATGCATACAGCTGTCGGGGCATACGCTTTACAGACGGCGGTGAAACGCCTGTCACAATCACACTAAACAAAGAGTACGGAACCCACTCATGGATATTCGTAAGATTAAAAAACTGATCGAGCTGGTTGAGAAGAATCAGGCATCTCGAACTGGAAATCTCCGAAGGCGAAGGTCGAGTACGCATCAGCCGTGCAGCTCCTGCCACAGAGTTTCCTAATGATGCAACAAGCTTACGCTGCACCAATGATTAAAGCAGCCAGCTCAATCTAACGCAGCCGCTCAGCGGCAGCCGTTCCTTCCAGCAGGCTTCCAGCAGCAGCCGGAAATCGATGGTCACATCGTACGCTCCCCGATGGTTGGTACTCTACCACCGCACCCCAAAGCCCGGACTGTACCAAAAGCGTTCATCGAAGTGGGTCAGAAAGAAGTCAACGTGGGCGATACCCTGTGCATCGTTGAAGCCATGAAAATGATGAACCAGATCGAAGCGGACAAAATCCAGGCAGTGAAAGCAATTCTGGTCGAAAGCGGACAACCGGTAAATTTGACGAGCCGCTGGTCGTCATCGAGTAACAGGCGAACATGCTGGATAAAATTGTTATTGCCAACCGCGCTTGAGATTGCATTGCGTATTCTTCGGCCTATCGTAAAGAACTGGGCATCAAGACTGTCGCTGGCTGCACTCCAGCGGATCGCGATCTAAAACACGTATTACTGGCAGATGAAACGGTCTGTATTGGCCCTGCTCCGTCAGTAAAAGTTATCTGAACATCCCGGCAATCATAAGCGCCGCTGAAATCCTCTGCCGGCGCAGTAGCAATCCGCATCCGGGTTACGGCTTCCTCTCCGAGAACGCCAACTTTGCCAGGCAGGTTACAGACGCTCGGCTTTATCTTCATTGGCCCGAAAGCAGACACTATTCGCCTGATGGGTGACAAAGTGATGTCGGCAATCGCGGCGATGAAAAAGCGAACGTTCCTTGCCGTACCAGGTTCTGACGGCCCGCTGGGCGACGATGGATAAAAACCGTTGCCATTGCTAAACGCATAGGTTATCCGGTGATTATCAAAGCCTCCGGCGGCGGCGGCGGTCGTGGTATGCGTGTAGTGCGCGGCGACGCTGAGCAGCGCAATCCATCTCCATGACCCGTGCGGAAGCGAAGGCCGCATTCAGCCAACGATGCCAGTTTACATGGAGAAATGGAAAATCCTCGCCGCATCGAGATTCAGGTACTGGCAAGTCAGGGCAACATCTATCTGGCGGAACGTGACTGCTCTATGCAGCGTCGTCACCAGAAAGTGGTCGAAGAAGCACCAGCACCGGAATTACACCCGGAACTGCGTCTTCATCCGCGGCGAACGTTGTGCTAAAGCGTGTGTTGATGTCAGCTATCGCGGTGCAGGTACTTTCGAGTTTGTTCGAAAACGGCGAGTTCTATTTCATCAGGAAATGAACACCCGTATTCAGGTAGAACACCCGGTTACAGAAATGATCCACCGGCATTGACCTGATCAAAGAACAGCTGCGTATCGCTGCCGGTCAACCGCGTCGATCAAGCCGCAAGAAGAAGTTCACGTTCGCGGCCATGCGGTGGAATGTCGTATCAGCGCCGAAGATCCGAACACCTTCCTGCCAAGCCCGAGCAAAATCACCCGTTTCCACGCACCTGGCGGTTTTGGAGTGCGTTGGGGTCTCATATCTACGCGGAGCTACACCCGTACCGCCGTACTATACAAACTCAATGATCGGTAAGCTGATTTGCTACGGTGAAAACCGTGACGTGGCGAGTGCTCGCATGAAGAATGCGCTGCAGAATGATCATCGACGGTATCAAAACCAACGTTGATCTGCAGATCCGCATCATGAATGACGAAGAACTTCCAGCATGGTGGCACTAACATCCACTATCTGGAGAAAAGAAACTCGGTCTTCAGGAAAATAAGACTACGAAAGCGTCAAAAGGCCGGATTTTCCGGCCTTTATTACAGGGATCTGGCAACCCCCGCAAGGTACAATCCTCTTTTCTTCACCCATCAGGGACAAAAAATGGACACTCGTTTTGTTCAGGCCCATACAAGAAGGCGCGCTGGGCGCTGGGGCTGACCCTTTTTGTGTTGCTTCTTGGTTTTGGTTAGTAGCCGCTTACTTACCTGGCGGTGCCCCCGGTTTTACCGGCTTTCCGCGCTGAGTTTGAGATGGCCCGCCTGCATCCTGACGCCGCTACTGTTTATTGGACTGTGCTGGGCGATGGTGGGAATTTATCTATCGCGATATCCCACTGGAGGATGATGCAGCTTGAAGTAATTCTACCGCAGGTCGCCTATCTGGTGGTGGTGTTCGGTATCTCTGTTTTATGCACGATGCGTAAACGGAGCACCGGCACCGCTGCTTAATAATTATTTCCTCGGCAGCCGCTCTGTGGGCGGTATTGTGCTGGCGATGACGCTCACCGCGACCTATATCAGTGCCAGTTCTGGTTTATCGGCGGGCCGGGAGCTGCTTATAAATACGGCCTGGGCTGGGTATTGCTGGCGATGATTCGGCTTCTGCAGTCTGGCTTTCACTCGGTATTCTCGGCAAAGAAGTTTGCGATTCTTGCGCGCCGCTACAATGCAGTGACATGAACGATATGCTGTTTGCCCGCTACCAGAGTCGTCTTCTGGTGTGGCTGGCGGGATTGAGTTTGCTGGTTGCGTTCGTTTGGTTGCGATGACCGTGCAGTTTATCGGCGGTGCGCGCCTGCTGGAAATCGCGGCGGGTATTCCTTATGAAACCGGGCTGCTGATTTTGGTATCGGCATTGCGTTATATACCGCCTTTGGTGGCTTTTTTCGCGCCAGCGTGCTGAACGACACCATGCAAGGGCTTGTGATGCTGATTGGCACCGTTGTTGCTGCTTATTGGCGTGGTACATGCCGCTGGCGGCTTAAGCAACGCAGTACAGACCTTGCAAACCACCGAATACCACTGCAACTGGTTACGCCACAGGCGCTGAAAGGCGATATTCTGTCGCCTGCCTTTATGACGTGATTCTGGGTACTGGTGTGCTTTGGCGTGATTGGCCTGCCGCATACTGCGGTGCGCTGTATCTCTTATAAAGACAACAAAGCAGTACACCGGGGATATCATCGGTACGATTAGCAGTCATAATCCTGATGTTCGGTATGCACCTGGCCGGAGCGGTGGGTGGTGGTGATCCCCGATCTCACCGTACCGGATCTGGTGATCCCGACGTTTAATGGTAAAAGTGCTGCCACCTTTTGCTGCCGGGATCTTTTTCTGGCTGCACCTATATGGCTGCGATCATGTCGATAATTAACCCCAACTGCTGCAAAGTTCCGCTACGATCATTAAAGATCTCTATCTCGTCCGGATCAAATGCAAAACAGAGACGCGTCTGAAGCGGATGTCGGCGGTAATTACGTTGGTTCTCGGCGCGTTGCTGCTTGCCGCCTGGAAGCCGCCGAAATGATCATCTGGCTGATTGCTAGCCTTCGGTGGGCTGGAAACCGTTTTCCTGGCTGGCCGCTGGTGCTGGGTCTTCCACTGGGAACGCGCAACGCCCAAAGCGCGCTAAGTGCGATGATCCGTTGGCAGCGTGCTGTATGCCGTACTCGCGACGCTGAATATTTCAATTACCTGGGCTTCCACCTATTATTGCCCTCGTTACTACTAAGTTTTCGGCTTTCCTGGTCCACGGAAACCGTTTCGGTACATCCGTCCCGCAAACTACCGTTTTGACTACTGATAAATAAGAAATTTTGCCATTGCCTTGGATCAACTGAAACTGAACACCGGCGCAGACGCGGAAAGTCTTAGCGATGCGCTGGTGGAAGCGGTGCCGTTTCTATCACTTTTTCCGGGATACCCACGATACGCCAGTATTTGGGCCGCTGCCGGGCGAAACGCGCCTGTGGGGCGACACCGATGTGATTGGTCTGTTCGACGCTGGAAACCGATATGAACGACGTGGTGGCGATTCTGGAAAACCATCGCTGCTCGGCGCAGGCTTCGCCTCGAACAACTAGAAGATAAAGACTGGGAAGCGCGAATGGATGGATAATTTCCACCGATGCGCTTTGGTGAACGACTGTGGATCTGCCCTAGCTGGCGTGATGTGCCGGACGAAAACGCCGTCAACGTGATGTTAGATCCAGGGCTGGCGGCGTTTTCAGTACAATTACCCTGATCCAACCACCTCTGTGCCTGCAATGGCTCGACCAGCCTCGATTTAACCGGTAAAACAGTCATCGACTTGGCTGTGGTTCCGGCATTCTGGCGATCGCAGCGCTGAAACTGGGTGCAACAAAAGCCATTGGTATTGATATCGATCACCAGGCGATTCAGGCCAGCCGCGACAGCACCAGACAATGGCGTTTTCTGACCGTCTGGAACTCTACTTACCGAAAGATCAGCCAGAAGAAGTAGCCGACGTGGTGGTCGCTAACATCCTTACAGGCCCATTACGTGAACTGCTTCCTGTCTCTTTTATACACATCTGACGCTGCCGACGAACAC ++ 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+GTTTATACTTCGTTCAATTACGTATTGCTGCCACTTGCTATATACGTGTCTTCGTCAGCAGCGTCAGATGTGTATAAGAGACAGCTCAAAGGCTATTATTAATACGGTTATCCACAGAATCAAGGATAACGCCGGAAAGAACATGTGAGCAAAAGCCAAAGCACCGGAACAAACCAGCGCCGTTGCCGTTTTTTTCCATAGGCTCCGCCCCTGGCGAGCATCACCAAAATCGACGCGCTCAAGTCGGAAATTGGCGAAACCGATAGGACTACTCTAAAGATACAAGCGTTTCCCCTGGAGGCTCCCTCGTGCGCTCTCCTGTTCAAGGCCCTTGCCCAGCACCCCAGATACCGCATCGCCTTTCTCGCTTCCCGGAAGCGTAGCTCTCATAGCTCACGCTGTTGGTATCTCCAGTTCGGTGTGGGTCGTTCGCTCCAAGCTGGGCGGTGTGCACGAACCCCGTTCAGCCCGACCGCTGCGCCTTGTCCGAAGTAACTATCGTCTTGGAGTCAACCCGGAAAGACACGACTTAACGCCACTGGCAGCATGCATTGGTAACTGATTTAGAGGAGTTGAGTCTTGAGTTATGCACCTGATAAGGCTAAACTGAAAGAACAAGTTTTTGGCGACTGTGCTCCTCAAGGCCAGTTACCTCCAGTTCAAAGGCGCCAGCTCTATGGACAGCTGAAGAGCCGCCCGCCAGAGGCGGTTTTCCAGGGTTCATGGGGATGGCGCTCTTTGAACCGGGCTGAAAAGCGCATCGCAAAACTGTTCTTTTCAGTTGCTTATCGGGTGCGCCCCTCGAGACTCAACTTCCTCCCCCAAATCAGTTACCAATGGCTGCTGCCAGTAACAAAATCGTATCTTTCGGTTAGTAGTTACCGGATAAGGCTTACGGCTGTCCTACGCTGGGCTGAAAATTCGTACAGCCAGCGGAGCGAACGACCTACGCCGGAACTGGTATGAGAGCGCCGCGTATTCGAGGAGAAGGCGGACATGAGTATCGATGAAGCCGGGATCAGATGAGAGAGCGCGCGCGAATTTCCAGGAAATTTGT ++ +(%%($%%%%%'6G1;&&&=57;9:780(('$$()/0++,-)(('.*%$$+,40431(,)'1--7;;7@D:.,)'3443,(-/+3??@63/*1%%+'*$&'$$20068?C<))7'4815/&<)*+4FI>>:A;G:<02-.8:>0//3./9@LOC-5&988,/66-BEGGC>8;/2+-)38=>1;2122&-+,('&-=5+<2(:36-5+8779,.5?AF<=<58(+'*$$)*--*.3/4,%#$&09;68,+5;0AD?***'&#&,68FD==DG>62*,#&5956&-+$%'02470;/591:/)()'(56%%+-+/''$*.-/+.)).*%'1$$)*<%#&56=;3:&'0,%(9-8:9B;;/%%&'1/>.959;7?EC@@DB/19;;;9>@==F48)AG;:=CA97C87'&&&)9-$$%&)42<@A<432%,0139=>28A:1:AG8?/:-.)0:6.8=1(&-.'/'(543()&&84%%%%%:/5&$&-1/,$*+/024*(+4/()+4442)(*50?098:80%0$'&&.4-//%*-1,7.,&&&(&&(&&&))6'(,*-,*(%%%%#'&%'$+,-(&$4*24-,--0*%)(+$#&*0.7%+0:53%$$$$*)$$21998&''(*+.1+-(&%011,+$2%'%-.()206:<;88282+1'&&.$%'&%%%'%/0..-)$$--$'($&)0,%.&(-+,-'($$$&,'($&%$#%$%%$#$#&%#$%&'+,.*/)-&%#%,/.&,)-')00--96.+%#(:4=8*+*))*%'%$)2&%#)::;0,,'###'%($*'+$&%&+2,5-(&%'%'%&$.*$)$*'$%($'')$%#%$()%&'&%&%)%$$&'$$#%(*/1$%%$$$#&*#$ +@e8221e53-73b5-492a-a94b-1304576f10b7 +GATGTGCTTCGTTCAGTTACGTATTGCGCTAGAGGCTCACTCTCTGTCCTCGTCGGCAGCGTCAGATGTGTAATATAAGAGACAGAAAAATTCTCTTCTTTTCAAGATGCTTTGGTTTGGGCAGAAAGCTAATCCTAGCAAAACGATAATAAGATCTCAGACGGTGTGGGGTTTATTGAAAAATGAAAAGAGTGGATTCACTCAACAAAACAACGATGCATTTTTTGGACAACACCACTGTCTATATACGTACTCATATGTTTCACAGTGTCGTATATTTGAGTCTATGTTACGTACGTTACAGGAGCCTATTTTGACTGGTTACAGGCATTCTTGCAGCAGCTTACAGAAACCCTAGCTGTAATCCAAAGTGACTACCAGGGCTAGACGAACTTTATCCCCCACAAAACCCGCTTTTTAAACGGATCTTCTTGAGATCATTCATGGAGAATCGTAATCTCTTAGCATACAAACGAAAAAAACCGCCCAGCAAGGCAGTTTTTCGAAAGTTCTCCAAAGGCAGCAACTCTTTGAACCAGGGTAACTATTGGAGGAGCACAGTCACCAAAACTTGTCCTTTCAGTTTAGCCTTAACCGGCGCATAGCTTCCAAGACTAACTCCTCTAAATCAGTTACCAGTGGCTGCTGCCAGTGGCGTTTTGTCGTATCTTTGGGGTTGGACTCAAGTCGATAGTTACCAGCGGATAAGACGCAGCGGTCAGACTGAACAGGGGTTCGTGCATACAGTCCGAAAAAGCAGGAGCGAACTGCCTACCGGAACTAGCGAGTGTCAGGCGTGGAGATTAGATAAACGGCCATAACAGCGGAATGACACCGGTAAACCGAAGGCGGGAACAGGAGAGCGCACGAGGGAGCTACCAGGGGAAACGCCTGGGATCTTTATAGTCCTGTCGGGTTTCGCCACCACTGATTAGGCAATCAGATTTCGTGATGCTTGTCAGAGGCAGACCTATGGAAAACGGCAACGCCGCATCCTTTCCTTCCTTTGCAGTTATTCCGCTTAGTCTTTATCCAGCCATTCGTAAGTAGCAACGCCTGCAGTCACGCTTAGGAGCACAGCGACCCGGGTGGGACTGCGGCGAAACACGAAATGGCGCTGGATAAAGAGACAAGCAGAAATCAATCGAAAGAGCAAGGAAAGGATTGCCTTTGACGAAGCATCACGAAATCTCACAGAAGACACGCACATCGTCAGCGGCGTCAGATGTGTATAAGAGACAGAGCTGAACGGAGTGATTTCGCGCAGCAGGATGGAGTTGGTCAGGCGATTGCAGCGAAGACACTTTGAACGCTTCCACGTAGTCAAGCGTTGCCGGATCTTTACCTGATCACGATGTTCTACTCAACCGCCCAGAAAGTTACAAACGCCAGCACTTCCGGTCTGAGCAAAGTTAGACAGCAGTTTCGGTGATGATCAGAGAAGCGGGTTATGGGTGATAGCCGGGGCGATGAAATCCGCACGGTACCATTTGGTTCCTGTGGATCAGCTGGTAGAACGCGTGCTGACCGTTAGTGCCTGGTTCACCCCGGATAATCGGGCCAGTCTAGTAATTCGACGTTACCGTTACAGTCAACGTACTTACCGTTGGACTCCATATTGCCCTGCTAGAGTACGCCGCGAAACGGGCCATATACTGGTCATACGGCGGAATCGCTTCAGTTTCGCGCCAAAGAAATTGTTGTACTGGATGCAATCAGCGCCAGTAAATCACGGGCAGGTTTTTCTCGGCAGGCGTGGTGGAGAAATGCTTGTCCATCGCGTGTGCGCCAGAGAAGCAGTTCAACGAAGTTATCGCAGAAAGCCGATGGAGAGAACAATCCGACAGGCCAATCATGACCATAAAGGTAACGACCACCGACCCAGTCCCCGGAGACTCGGGCATGTTGGCGGTATCAATGCAAACTCGCCAACGGCTTTGGCGTTGGTTAGGAAGCGCGCCGCAAAGTGATGTTTCGCAACGTGTTTTGCATCACCAGCCGCTTTCAGAACCAGTCACGCGCACTATGGGCGTTGGTCATGGTTTCCTGAGTGGTGAAGGTTTTAGATGCTACCAGAGTTGGCAATGGTTTCGGGTTTACTTTTTTCAGCACTTCCGCGATGTGAGTCCATCGACGTTAGAAAGTGCATGTTCAGGTGATTTTTGTACGGACGCAGTGCTTCAGCCAGTCTTTATGCCCATGGAGCCGAGTCAGAACCGCCGATCGATGTTCACTACGTCAGTGATTGCTTTGCCAGTACTTATAACCCTTCCACTCACCGGAAATAATCGCTTGCGAAGGTTTCATCTTCTCCAGCCCGCGTTGACTTCCAGCATAACGTCTTACACCCATCAAGCAGAATCCAGGGTATTGCTACGGACACGCAGCGCTACGTGCAGCACGGCGCAGTTTTCGGTGCAGTTGATCTTCTCACCAGAGAGAACATCGACTTAATCGCGCCCACTGAATCCGCACTCTTTCATAGATCTTATGAGTTCGCCAGCGTCTCTTCAGTGATGCGGTTTGGGTAATCCACCAGCATCTGATCGTCGAAGGTTGCGGAGAACTTAGAAAAACAGTCGCCGTCTTTAGCAAAGATCGGCGATCGTAACGTCTTTCATTTCAACTCAGGAAGTGTTTCTGTAGTACCTGCCAGGCAGCGGTCTGCGTTGGATTGATGTTTTTCATTAGCAATACTCTTCTGATTTTGAAATTGTGACTGGAAGATTAGCGCCAGTCACAGAAAAATGTGATGGTTTAGTACCGTTAGCGTAATGTGGCCGAGTAAACTAACAGCGCAGTGAAGCATTTATTAGCTGAACTACTGACCGCCAAGTGGATGAAAAATCCGCATGACCCCATCGTTGACAACCGCCCCGCTCACCTTTATTTATAAATGTACTACCTGCATGGCGCAGGCCAGAAGAGCGCGTTGCCCAAGTAACGAAGTGTTGGAGGAGCCAGTCCTGTGATAACACCTGAGGGGAGTGCATCGCCGAGGTGATTGAACGGCTGGCCACGGATGGCATCACATCGGCTACAGAGGCTGAATCCCTGATTGTCACCAAGCGTTCGCAGTCAGGCGTTTCGCAAGTGGTAAGACACTTCTGGGTGAAAATAGTAGCGAAGTATCGCTCTGCGCCCACCCGTCTTCCGCTCTTCCCTTGTGCAAGGCTGAAAATGGATCCCTGACACGAGGTAGTTATGTCTGGAAATTGTTGTCTCCAAGTTGGCGGGTACCAGCGTAGCTGATTTGACGCCATGAACCGCAGCGCTGATATTGTGCTTTCTGATTGATGCCAACGTGCGTTTAAGTAGTCGTCCTCTCGGCTTCTGCTGGTATCACTAATCTGCTGGTCGCTTTGGCGGAAGGCTGGAACCTGGCGAGCGATTGAAAAACTCTGACGCTATTCGCAGCATCCGGTTTGCCATTCTGGAACGTCACCGTTACCCGAACGTTATCCGTGAAGAGATTGAACGTCTGCTGAGAACATTACTGTTCTGGCAGAAGCGGCGGCGCTGGCAACGTCTCCGGCGCTGACGGATGAGCTGGTCAGCCACGGCGAGCTGATGATGCTCGACCCTGCTGTTGCTGTCGAAATCCTGCACTGAACGCAGTATTTCAGAGCACAGTGGTTTGATGTACGTAAAGTGATGCGTACCAACGACCGATTTGGTCGTACAGAGCCAGATCTTAGCCGCGCTGGCGAACTGGCCGCGCTGCGGCTATCACGCCTCAATGACGGCGAAGTGATCACCCAGGGATTTATCGGTAGCGAAAATAAAGGTCGTACAACGACCTTGTGGGTGGAGGCAACAGTTATACGGCAGCCTTGCTGGCGGAAGCTTCACCGCATCTCGTGTTGATATCTGGACCGACGTCCCGGGCATCTACACACCACCGATCCACGCGTAGTTTCCGCAGCAAAACGCATTGATAAATCGCGTTTTTACCGAAGCGGCAGAGATGGCAACTTTTAGTGCTGCAAAAGTACTGCATCCGGCAACGTTACGCTACCGCAGTACACGCAGCGATATCCCGGTCTTTGTCGGCTCCGGCAAAGACCGCGCAGGTGGTACGCTGGTGTGCAATAAAACTGAAAATCCGCCGCTGTTCCGCGCTGGCGCTAAATCGCAATCAGACTCTGCTCACTTTGCACAGCCTGAATATACTGCATTCTCGCCTTCCTCGCGGAAGTTTTCGGCATCTCGCGCGGCGTAATATTTCGGTAGACTTAATCACCACGTCAGAAGTAGGCGTGGCATTAACAACCGCCAGTACCACCGGTTCAACCTCCACTGGCGATACGTTGCTGACGCAATCTGCTGATGGAGCTTTCCGCACTGTACCGGGTGGAAGTAGAAGAAGGTCTGGCGCTGGTCGCGTTGAGTTGGCAATGGCTTCTGTCAAAAGCCTGCAGCGTTGGCAAAGAAGGTGTCAGCGTACTGAACCGTTCAACATTCGCATGATTTATTTACGGCGCATCCAGCCATAACCTGTGCTTCCTGGTGCCCGGCGAAGATGCGAGCAGGTGGTGCAAAAACTGCATAGTAATTTGTTGAGTAAATACTGTATGGCCTGGAAGCTATATTTCGGAGCCGTATTGATTTTTGCTTGTCACTATACTCATCAATAAACGAACCTGTACTCTGTTAACCAACATCTTTATCGGAGAATAATTGCCTTTAATTTCTTACATCTCTACGTAAATGCAAATGAAGAGATAATAAGTTAGGCAGGCAAGTGCAGCTCTATAATTGTCTATGAGCAGATTCCCGTACACACTGAACTCTCTGGCTCACTGGGGGCACCAGCGCTCCCCGTATTACCCAAAAGAGATGACTGAACGCGAGCAGCGTGAACTTAAAACACTGCTGGATCGGGCGCGGATTGCGCATGGTCGCTGTACTGACCAACTCCGAAACCAACAGCATTGAAAAAGATACATCGATAAAGTGGTCAGGCGTGAGGCTGAAGCAAAAAAAAAGCCCGCCAGTTAAAGAAAAAGCAGGCTTATAAACCAGCGGATCCACCAGAAGCGTCATTTAGCTGGTCAGCAAATGCGTCGACGCGCGGCAGGCGCAGTTAGCGCCCCTTCTTTTACGCCCGGCGAAGTCAAAAGCCTTACCGTTTGGACGCCGGGCGACCGCCTTTTTCCGCCCGTTTTCCATCATGTGGCACGACTGGACGTTTAATACCTACAGTTTTTCGGTTTGGCCTTCGCTTTAGGTTTTGCCTCGGAAGAGGAATTTTCAATGAGCTTAAAGAGGTCGATTAACTCATCACGTCAGTTAAATCACGCCATTCCCCAGCGGGAATGCCGCTTAAACTAACGTTCATGATGCGCGTACGTTCCAGCTTTTTCACTTCGTAACAAAGTGCTCGCACATGCGACGGATCTGACGGTTCCAGCCCCTGCACCGGGGTAATGCGGAAGACAAACTAACGCTTCTTTTTTGGCTTTACACTTTTTCGTCACCGTCCGAGGATCGCCTCCCGCCCCATACCACGAATGATTCATCGGTAATCAGTTTATCGACCGTCACCAGATACTCTTTCTCATGATCGTTACCGCGGAGGATCTTATTCACCAGATCGCTGTGATTGGTGAGGAAAATCAGCCTAAGTCTTTATCAGGCGGCCAATCAGGAACACGCGTTGCTGTGGTTAACGAAATCGACAATGTTATCGCGCTCGCCATCTTCGGTGGTGCTGACAATACCGACGGAGGCTTGTTCAGGGCGATAAGTACCAAATCTTCGGCTTCAGGCTCAATCCAGCTGACCACGTTTACTTTCCACAACGTCGCCGGAGTTTCACCTGATCGCCAATGGTGGCTCACTCGCCATTAAGGAACACATTGCCTTTACTCGATATAGCGATCCGCTTCGCGGCGTAGAGCAAGATTCCGCTTTCGCTGATACATTTGGCCCAAACGAGGCTGATGAGTCAGGCAGCATAAATTCTCCTGTAAAACGCGGAATATACCGTACCTCTTGGCAGGAAAAACAGGGTTATGCAGCAACGTCAAGAATTAAATGTGATCTGCCACGCCTTTTATCACAAAGTGTCTCCGGAAGTACGATGCAAATTTGCCTGGCAAAATAAGGATGATCAACATATTACGAACCACTGCACACCTTGCTACTGATGGCTACTACTGAAGGCTTCGATGTGCAGAAAGCGCTATTTCTCCCCCCATGCAAAGAGTGAAAAATCGGCACGAAGGCCATCATGATGGGGTTATATCAGATCAAGCCAGGTGAGAAAGCGTGTACACAAATGTACAGGAGAACCAGGAAGGCAGCAATGCAAACAGTGACGATATCCGTTTGGTTGTGAAGATTGCCCAGCTCTATTACGAACAGGATATGACGCGGGTGCCGTCGCGCGAACTGGAGTATTTACCGCACCACCATCAGCCGCTTGCTTAAACGAGGCCATGATCAGGGAATTGTCACCATCACCATCAACTACAACGAAATCTCTCTGACACCGACAGCAACTAAACAAAAAGTTTGGCCTGAAAGACGTTGTGGTGGTGTCAGGAAATGATGAGGATGAAGAGACTCAACTGGCGATGATGGGGTTACACGGCGCGCAACTGCTGGATCGCTTGCTGGAGCCTGGCGATGTCAGTTTTCCTGGGGTCAGCGCGGTGAGCGTGGTTTAAAAAGCTTTGCATTACCTGCCACCAGGCGAAGCAATCGCGGCAGTTAATCTGCGTACCAATTATTGGCGGACCGTCCAGCTGATAAACTCGAAAGCCGCTATCACGTAAACACATTAACCTACAGCGCGGCAGCAAGCCTGCCAAGAAGGGAATCGCATCTCTCGCAGATTTTCCGGCTCTGCTGGATAACCCCTTAATTCGTAATGGGATCATGCAGTCTCAGCGCTTTAAAACCATCTCTGCCTGGGATAATCTGGATGTCGCCCTGGTGAATTGGCTCACACCAGCCATTCGCGACAGCGCTAACGGCATGCGTTTTTATGATGGTGAAGAGAGTGACGACCTGAATGCCCGCCAGGTTGCGCTAACCCGATATTTGCTCGCACTTTTTTGATATTCGGCGCAATGGATTTGAAACGAATATGAGCGAAAAAAACACTCTCTATCGAAATGAATAAATTGAATTAAAGCAGGCACGATATTCCATTGGCATTGCCATGAGTGAAGAAAATACAGCAGGATTGTTGAATTTGCACTGCGTGAAAATATATTAATTGTCTGAGGTAACGAATAGCAGCACAGCTGAACTATTATGAAATAAAAATCTTCCCGATGTTTGTAATAAAAATTACGGCGGGTCCCTATTATCTAAAAACAGGAGTCTATTATGCAAACGTGGTTAAATTTGCAGGATAAATCATTATCGTCACCGGCGGCGCATCAGTATAGGTCTGGCGATTGGCAGAATTAATAGCACAAGGCGCGAATGTACAGATGGTCGATATTCACGGTGGCGATGGACAATATGAAGGTCATAAAGGCTATCAGTTTGGCCGACCGATATTTCCAGCGCGCCAAAGAGGTAAATCATACGGGACGAAGCGCGAGAAATATCTTCAAGCGTGCAGCCGTGAGCGATTATATACGATTGTTTTCCGAGGTCATTTACGCGTCATACTAAATAAATACAAGTAAGTGCGGAAGCGTATAAGAAAAAAGCATTACATTAGAAAAGTATGCGTGAATATAAAAGCCAGAAGCGTTATTACAGCATTTGCTTTTATGATGATGATAAATCTTTGCGACGGCGCGATGCGATCACGGCGCTACATGGAAATGTTTGGGAATGGAACTGGGCTCAGAAGCAATATGATGTGGAGCGGGTGTTTTTGATCTAATATGGTGATAACCTTTCTTTTTAAAAGATGGAAAAAACAGACATACCTTTTTCGCAGAATATATGAAAAGCTTTAATGACGTGCATGACCTACCATCAGAAGTGATGAAACAAATGGTGCAGGAGTGCAGATATGACGCGGAAACGACGAGAATAAATATTATTTGCGTGATACCTTTTTGCCATGCACTTTGGATGGATATGGAATATCGGTGTTTAGTAACATAAGTAGCAGGAAGTGAATGGGTGC ++ 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++ 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++ 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ae0853da-5e92-45c3-b88b-20fed2a4964f +AAAGAGATGTTTTACCCCAGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCTTTGGGAGCTTACCAGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACGGGGGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCGCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCAGTCTCATAACTTCTTTCAGTACGATCATCAGTCAGTGAGTTAACT ++ +.($+)('7;JJE=;9;;,*??;IGH*&AIBJ@><53.).:0>CCAFAPLM84?7?@B0&,2<.58?;67=?D@C?JR=%:;BGZREC>&=>?@=ED@0/18<+9*,:/-8<;>?8:28=2066?F8893812+2,2(=@@88?@ +@c127e70a-405f-46c0-ae0b-e647ef99c3af +AGTTATGAGACTGGGAGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCAGAGGTGCTGATCGCTATTACGGAGTATCCTGCCGTGCCTATTATCCAGACTTATGGCAAGATTAAGCTTCCCGGAGAAAACTATCAAAACAGACGGTATGTTTTCACCATCCAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAAGAAAACGATCCTGACGCATCCTTCCTGTTTTCC ++ +''+039A>BD56<@D/9>FLGHAD?47;@@@BF=?@@?::8AB:<+-/:@:9;>1<574/.)3/-:?98IG2),(-888;CA0271=8./8////-2/430-,/0%%:-/=?IHA<,/0&('$$%()2113176')-+79>,&(%$$$'..,',')$&)&%.%%%%%%$%%##&)$''(+*()&,4587A@@@GJL;;))8719BDF844311:1//10)&'/00+<6=56-.:..7/.(-@?>AKH*. +@9a0e90b3-3c3e-4843-95cb-b1596828ed6f +AAAGAGATGTTTTACGGGAAAACAGGAAGGATGCGTCAGGATCGTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACCTGGTGTTCATACCGTCTGTTTTCGACAGTTTCTCTCCGGGGAAGCTAATCTGCCCGCCAAGTCTACGGATAACAGGGCACGGTGATACTCCGTAACGCGATCAACACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACACCCCCAGTCT ++ +BE1%7>?A=FFE7-5'.25855*%5410/:48:;5371>B85@9@=<836>;A648+,2/5+&@:05E<>A>;DDDBB@:765638DE)63$'73;<<<@8=39,9?IK4=5AMJPH<3+)'-.30FIGA0.701' +@162b5056-1cc5-40d8-a1de-6bebe548bc27 +TGTTTTACCCCGGGAAGCAGGAGAGGGATGCAATCTTTGCAGGATCGTTTTCCATTTTGCCCGCTAGCTATGCATGAAAGCGATGGTGTGATCACCGGGGAGCTTACGGTGTTGTCCACCGTCTGTTTCGACAAGTTTTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAGCAGGGCACAGGTGATACCGGCAGCGATCGCTTCCTCCACGCCTCCTGTCCCCGACACGCGCCGTCGATGAAGTTTTTTCTG ++ +%,68@8/-778/-((*),*;0/$&36882,/#$%$%)00-,6;<9?@JCDE34'())(&$''#$,,(1+?=95*$' +@c506ed82-9194-4814-9a9d-7532715b5f51 +AAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGGAGTATGCCCGGAGGTGCTGATCGCTATTACGGAGTATC ++ +(+;;<;.BDGD4:E?>?B<=??@7=@69885'8&.=>B?C77=A?>?ABCEBID71031;15IE@F9>,@=DKJ?1@CIG>99@=B>:BC:4@?=-%8?28;.:3=87;< +@aba91300-4618-4b54-beb5-01aefe1e0af8 +CGCTATTACGAAGGAGTATCACCGTGCCTGTTATCAGACTTATGGCAAGATTAGCTTCCGGAGAAAAAACTGTCGAAAACAGACGGTATGAACACCGTAAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTTCCCCGGGGTAAAACATCTCTTT ++ +42@A=BA<(/%$&*#&8-)<353-B3=<>>A@*%?458331.2'+3#%)+0.*4899%+/4-///((*)'()*337731,)0,>)1420))/==5678785(10)0-12-/=977:<75&99,$%):@B;:9:(),),(8221*:;00:2144KH=A6:**0$&%4355:;?C?8:D?=@C@86@;>A??64 +@e3986483-5f5e-480a-81bc-cfaac9c8678e +GCTATTACGAATTATCCACCGTGCCTATTATCAGACTTATGGCAGATTGGCTTTGGAGAGAAAACTGTCGAAAACCAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATACGGCGGAGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCGGGGTAAAACATCTCTTT ++ +(?A@=CE-3()(49))6,69>H>::/(79,%3(0:&&%*3)-0/23-5$)**+&6;<),%:CC=5?7562**'%%61>=?:;FDF@?:4>56>?3/(<;)0*02/36<<;AAABCDFE::JIF<9;5:4<:?>@-)'3'.1$&&$&,;:00C?'4=>((,@D9H?@B<;=HG=@=F<;CB>D?= +@7a97d860-e33a-4e27-b5be-c4754a2eb907 +ATTACGAAGTATCACGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCAAAGTGATCACCATTCGCTTTCATGCGCCTTGGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGAAGGGTAAAACATCTCTTT ++ +?>A?'-$%+?'%8$03F;;;=8*57>((?3:E?E?65%,0,.,B>77?AA69?<>??:78:@97424%%$'%')460((8,:;1/4////@;5;?@//5896:.+?:@KEA@LD=C22.+01849?D<>@;A=C29;5>8832,>>459;+;;)-(+$%$*77;6CAABDB?-0*+,(&$+&**8:85=??@))?%.7+*4/+(*.'($#%,,++4;EBB:B>78=8<=@GBDCGB@5;A+1<$6:EGDAG;:>>@@?H +@749ba682-4ec2-4367-8bb3-51878f06992d +CCGGGAAAGCGGAAGGATCGTCAGGATCGTTGCTACAGCTCTGCTACATATGCATGAAAGCGAATGGTGATGCTTTGGGACTTTACGGTGTTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCAGGGAAACTAATCTGCCAGCAAGTCTGGATAACAGGG ++ +#$$(+('&%,$)5;:8/&(,121165++.-/$$(%)(%#%'#$$$$&&%$%(3/1<222(666:=8<47/&$&)),&'&',-/.39=B>B?=-89;=>=;;;335686E;=9499=PA@-8<%/'/*+,)$77=7/-5//.-&(()**7',./102,&,&' +@3d6bdcab-ef5c-4ff8-a928-23066fb4e887 +CTGTTATCAGACTTATGGCAGATTAGCTTCCCGGAGAAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAAGTGATCACCATTCATCATGCATAGCTATGCGGGCAGACTGCGAAAACGATCCTGACTCCTTCCTGTTTTCCGGGGTAAAACATCTCTTT ++ +12551)$>,,/,,,AE??>==?6/.'''-8>B03<+,,-=CA@;;/09:6470999-%171+98==8<;6#'36;AC;7:689<<89%*./(&$++$-+--<-;=>55:4;*%&%*%/454@CAHA/318?G?4599=9?DEA@?E +@0b41ea60-ea37-43ef-a912-260c4d33a356 +CTGTTATCCAGACTTATGGCAGATTAGCTTCCGGAGAAAACTGCTTCGAAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCGCTATGCAGCGAGCTGAAAACGATCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT ++ +=B>B3+++7-2-))%&.%,3**749689:=1B0.3&)(-'$$%#%(*(((('$,)+(/+,,/48:>;62+7:)*.<;9>@DE75@?;>?::>-043+).2?;<(&551.;><:8G@6E@<6@7<6@1CE78BDB>?=?57I@'-G3;@B=>@F@?8794- +@cd8d2944-a807-434b-92d5-bfa925697c85 +GTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGGCATGAAAACAGACAGGTATGAACACCGTAAACTCGGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCTCCTTCCTGTTTTCCGGGGTAAAACATCTCTTT ++ +8?>>%%06/B@FEFG7=854742')9<=+3B9:<98%;<>3..-(&$*/13,*;8;1+&59ADB55<94<<:;99(&)+#&62-'('668:7855;=C><24B=>==>;B<:30=;=1;9575IF9A=E55<:@?GC;77=069<=25152/56)/,45?>@BE162;>:9DCE +@a492dd23-2c03-4d9b-a606-dee7268bd4fa +AAAGAGATGTTTTTGCGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCGCTATAGCTATGCATGAAAGCGAATGGTGATCCTTTGGGAGCTTACGGTGTTCATGCCAATCTGTTTTCGACAGTTTCTCTCCGAGGAAGCTAATCTGCCGCAAGTCTAGTTAAC ++ +F:&-/77;:@??=8%%$(#'+()%+9.99AB?==<<7/;;4/;;B>?-+(*2%%&0-1-=5;99GD=88>9>??=IC2:B?:%%*#*-&.1**,--;A::8BID?4&&%8'(B64>:;31&*,(5('7A04.>@CC;AA7%1-1%&-/5'%*%-+,/ +@4a58265a-1d25-47a1-b851-e7687203734f +GGGAAACCCAGGAGGATCGTCAGGATCGTTTTTTCAGCTCGCTGCTATGTATGCGCTGAAAGCGAATGGTGATCACTTTGGGGAGCTTACGGTGTTCATACTGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAAC ++ +)**%&&%5'%)*$..5%$$,70?B?:>?GBLB<0))%&'-78>.11/$$+($&$&%***2),=88=@,1A=:3<25;<959E;.9?BB*A=B>B9?LL;AA74C>CNEDFC=4=?@BB9@>>2-A14:C;..5 +@f9a56724-1fa4-4807-bacc-f0a85587afd7 +GAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTTTCATGCATAGCTATGCAGCGACTGGCGATCCTGACGCATCTTCTGTTTTCC ++ +414===BA;3-.21$+&')'%-20-,((+6:57(*+,139@@?A534546/24022**)$$$#&(--++-7<+6*.*(())(,-03<:(, +@e525f31a-e4d6-4fe6-a703-7038efa2f178 +GCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTCCCGGGTAAAACATCTCTTT ++ +;B@E::0+5511=2122@>52((''*HECB@C@?KHI +@eeef3ccf-2188-4382-8399-a9442bbbf40a +GCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT ++ +@=:3335937))43378KC?CKMEH?BC55=4C>?KDFCLC4@G363877800+7<=;3;;> diff -r 000000000000 -r 711d4deb7bdf test-data/bwa-mem-mt-genome.fa --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/bwa-mem-mt-genome.fa Sat May 23 13:37:48 2020 -0400 @@ -0,0 +1,238 @@ +>gi|251831106|ref|NC_012920.1| +GATCACAGGTCTATCACCCTATTAACCACTCACGGGAGCTCTCCATGCATTTGGTATTTTCGTCTGGGGG +GTATGCACGCGATAGCATTGCGAGACGCTGGAGCCGGAGCACCCTATGTCGCAGTATCTGTCTTTGATTC +CTGCCTCATCCTATTATTTATCGCACCTACGTTCAATATTACAGGCGAACATACTTACTAAAGTGTGTTA +ATTAATTAATGCTTGTAGGACATAATAATAACAATTGAATGTCTGCACAGCCACTTTCCACACAGACATC +ATAACAAAAAATTTCCACCAAACCCCCCCTCCCCCGCTTCTGGCCACAGCACTTAAACACATCTCTGCCA +AACCCCAAAAACAAAGAACCCTAACACCAGCCTAACCAGATTTCAAATTTTATCTTTTGGCGGTATGCAC +TTTTAACAGTCACCCCCCAACTAACACATTATTTTCCCCTCCCACTCCCATACTACTAATCTCATCAATA +CAACCCCCGCCCATCCTACCCAGCACACACACACCGCTGCTAACCCCATACCCCGAACCAACCAAACCCC +AAAGACACCCCCCACAGTTTATGTAGCTTACCTCCTCAAAGCAATACACTGAAAATGTTTAGACGGGCTC +ACATCACCCCATAAACAAATAGGTTTGGTCCTAGCCTTTCTATTAGCTCTTAGTAAGATTACACATGCAA +GCATCCCCGTTCCAGTGAGTTCACCCTCTAAATCACCACGATCAAAAGGAACAAGCATCAAGCACGCAGC +AATGCAGCTCAAAACGCTTAGCCTAGCCACACCCCCACGGGAAACAGCAGTGATTAACCTTTAGCAATAA +ACGAAAGTTTAACTAAGCTATACTAACCCCAGGGTTGGTCAATTTCGTGCCAGCCACCGCGGTCACACGA +TTAACCCAAGTCAATAGAAGCCGGCGTAAAGAGTGTTTTAGATCACCCCCTCCCCAATAAAGCTAAAACT +CACCTGAGTTGTAAAAAACTCCAGTTGACACAAAATAGACTACGAAAGTGGCTTTAACATATCTGAACAC +ACAATAGCTAAGACCCAAACTGGGATTAGATACCCCACTATGCTTAGCCCTAAACCTCAACAGTTAAATC +AACAAAACTGCTCGCCAGAACACTACGAGCCACAGCTTAAAACTCAAAGGACCTGGCGGTGCTTCATATC +CCTCTAGAGGAGCCTGTTCTGTAATCGATAAACCCCGATCAACCTCACCACCTCTTGCTCAGCCTATATA +CCGCCATCTTCAGCAAACCCTGATGAAGGCTACAAAGTAAGCGCAAGTACCCACGTAAAGACGTTAGGTC +AAGGTGTAGCCCATGAGGTGGCAAGAAATGGGCTACATTTTCTACCCCAGAAAACTACGATAGCCCTTAT +GAAACTTAAGGGTCGAAGGTGGATTTAGCAGTAAACTAAGAGTAGAGTGCTTAGTTGAACAGGGCCCTGA +AGCGCGTACACACCGCCCGTCACCCTCCTCAAGTATACTTCAAAGGACATTTAACTAAAACCCCTACGCA +TTTATATAGAGGAGACAAGTCGTAACATGGTAAGTGTACTGGAAAGTGCACTTGGACGAACCAGAGTGTA +GCTTAACACAAAGCACCCAACTTACACTTAGGAGATTTCAACTTAACTTGACCGCTCTGAGCTAAACCTA +GCCCCAAACCCACTCCACCTTACTACCAGACAACCTTAGCCAAACCATTTACCCAAATAAAGTATAGGCG +ATAGAAATTGAAACCTGGCGCAATAGATATAGTACCGCAAGGGAAAGATGAAAAATTATAACCAAGCATA +ATATAGCAAGGACTAACCCCTATACCTTCTGCATAATGAATTAACTAGAAATAACTTTGCAAGGAGAGCC +AAAGCTAAGACCCCCGAAACCAGACGAGCTACCTAAGAACAGCTAAAAGAGCACACCCGTCTATGTAGCA +AAATAGTGGGAAGATTTATAGGTAGAGGCGACAAACCTACCGAGCCTGGTGATAGCTGGTTGTCCAAGAT +AGAATCTTAGTTCAACTTTAAATTTGCCCACAGAACCCTCTAAATCCCCTTGTAAATTTAACTGTTAGTC +CAAAGAGGAACAGCTCTTTGGACACTAGGAAAAAACCTTGTAGAGAGAGTAAAAAATTTAACACCCATAG +TAGGCCTAAAAGCAGCCACCAATTAAGAAAGCGTTCAAGCTCAACACCCACTACCTAAAAAATCCCAAAC +ATATAACTGAACTCCTCACACCCAATTGGACCAATCTATCACCCTATAGAAGAACTAATGTTAGTATAAG +TAACATGAAAACATTCTCCTCCGCATAAGCCTGCGTCAGATTAAAACACTGAACTGACAATTAACAGCCC +AATATCTACAATCAACCAACAAGTCATTATTACCCTCACTGTCAACCCAACACAGGCATGCTCATAAGGA +AAGGTTAAAAAAAGTAAAAGGAACTCGGCAAATCTTACCCCGCCTGTTTACCAAAAACATCACCTCTAGC +ATCACCAGTATTAGAGGCACCGCCTGCCCAGTGACACATGTTTAACGGCCGCGGTACCCTAACCGTGCAA +AGGTAGCATAATCACTTGTTCCTTAAATAGGGACCTGTATGAATGGCTCCACGAGGGTTCAGCTGTCTCT +TACTTTTAACCAGTGAAATTGACCTGCCCGTGAAGAGGCGGGCATAACACAGCAAGACGAGAAGACCCTA +TGGAGCTTTAATTTATTAATGCAAACAGTACCTAACAAACCCACAGGTCCTAAACTACCAAACCTGCATT +AAAAATTTCGGTTGGGGCGACCTCGGAGCAGAACCCAACCTCCGAGCAGTACATGCTAAGACTTCACCAG +TCAAAGCGAACTACTATACTCAATTGATCCAATAACTTGACCAACGGAACAAGTTACCCTAGGGATAACA +GCGCAATCCTATTCTAGAGTCCATATCAACAATAGGGTTTACGACCTCGATGTTGGATCAGGACATCCCG +ATGGTGCAGCCGCTATTAAAGGTTCGTTTGTTCAACGATTAAAGTCCTACGTGATCTGAGTTCAGACCGG +AGTAATCCAGGTCGGTTTCTATCTACNTTCAAATTCCTCCCTGTACGAAAGGACAAGAGAAATAAGGCCT +ACTTCACAAAGCGCCTTCCCCCGTAAATGATATCATCTCAACTTAGTATTATACCCACACCCACCCAAGA +ACAGGGTTTGTTAAGATGGCAGAGCCCGGTAATCGCATAAAACTTAAAACTTTACAGTCAGAGGTTCAAT +TCCTCTTCTTAACAACATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCA +TTCCTAATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTTGTAGGCC +CCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCCCTAAAACCCGCCAC +ATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACCATCGCTCTTCTACTATGAACCCCC +CTCCCCATACCCAACCCCCTGGTCAACCTCAACCTAGGCCTCCTATTTATTCTAGCCACCTCTAGCCTAG +CCGTTTACTCAATCCTCTGATCAGGGTGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGC +AGTAGCCCAAACAATCTCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGC +TCCTTTAACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCCTTGG +CCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTTGCCGAAGGGGAGTC +CGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTCGCCCTATTCTTCATAGCCGAATAC +ACAAACATTATTATAATAAACACCCTCACCACTACAATCTTCCTAGGAACAACATATGACGCACTCTCCC +CTGAACTCTACACAACATATTTTGTCACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAAC +AGCATACCCCCGATTCCGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTA +GCATTACTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTAAGAAATAT +GTCTGATAAAAGAGTTACTTTGATAGAGTAAATAATAGGAGCTTAAACCCCCTTATTTCTAGGACTATGA +GAATCGAACCCATCCCTGAGAATCCAAAATTCTCCGTGCCACCTATCACACCCCATCCTAAAGTAAGGTC +AGCTAAATAAGCTATCGGGCCCATACCCCGAAAATGTTGGTTATACCCTTCCCGTACTAATTAATCCCCT +GGCCCAACCCGTCATCTACTCTACCATCTTTGCAGGCACACTCATCACAGCGCTAAGCTCGCACTGATTT +TTTACCTGAGTAGGCCTAGAAATAAACATGCTAGCTTTTATTCCAGTTCTAACCAAAAAAATAAACCCTC +GTTCCACAGAAGCTGCCATCAAGTATTTCCTCACGCAAGCAACCGCATCCATAATCCTTCTAATAGCTAT +CCTCTTCAACAATATACTCTCCGGACAATGAACCATAACCAATACTACCAATCAATACTCATCATTAATA +ATCATAATAGCTATAGCAATAAAACTAGGAATAGCCCCCTTTCACTTCTGAGTCCCAGAGGTTACCCAAG +GCACCCCTCTGACATCCGGCCTGCTTCTTCTCACATGACAAAAACTAGCCCCCATCTCAATCATATACCA +AATCTCTCCCTCACTAAACGTAAGCCTTCTCCTCACTCTCTCAATCTTATCCATCATAGCAGGCAGTTGA +GGTGGATTAAACCAAACCCAGCTACGCAAAATCTTAGCATACTCCTCAATTACCCACATAGGATGAATAA +TAGCAGTTCTACCGTACAACCCTAACATAACCATTCTTAATTTAACTATTTATATTATCCTAACTACTAC +CGCATTCCTACTACTCAACTTAAACTCCAGCACCACGACCCTACTACTATCTCGCACCTGAAACAAGCTA +ACATGACTAACACCCTTAATTCCATCCACCCTCCTCTCCCTAGGAGGCCTGCCCCCGCTAACCGGCTTTT +TGCCCAAATGGGCCATTATCGAAGAATTCACAAAAAACAATAGCCTCATCATCCCCACCATCATAGCCAC +CATCACCCTCCTTAACCTCTACTTCTACCTACGCCTAATCTACTCCACCTCAATCACACTACTCCCCATA +TCTAACAACGTAAAAATAAAATGACAGTTTGAACATACAAAACCCACCCCATTCCTCCCCACACTCATCG +CCCTTACCACGCTACTCCTACCTATCTCCCCTTTTATACTAATAATCTTATAGAAATTTAGGTTAAATAC +AGACCAAGAGCCTTCAAAGCCCTCAGTAAGTTGCAATACTTAATTTCTGTAACAGCTAAGGACTGCAAAA +CCCCACTCTGCATCAACTGAACGCAAATCAGCCACTTTAATTAAGCTAAGCCCTTACTAGACCAATGGGA +CTTAAACCCACAAACACTTAGTTAACAGCTAAGCACCCTAATCAACTGGCTTCAATCTACTTCTCCCGCC +GCCGGGAAAAAAGGCGGGAGAAGCCCCGGCAGGTTTGAAGCTGCTTCTTCGAATTTGCAATTCAATATGA +AAATCACCTCGGAGCTGGTAAAAAGAGGCCTAACCCCTGTCTTTAGATTTACAGTCCAATGCTTCACTCA +GCCATTTTACCTCACCCCCACTGATGTTCGCCGACCGTTGACTATTCTCTACAAACCACAAAGACATTGG +AACACTATACCTATTATTCGGCGCATGAGCTGGAGTCCTAGGCACAGCTCTAAGCCTCCTTATTCGAGCC +GAGCTGGGCCAGCCAGGCAACCTTCTAGGTAACGACCACATCTACAACGTTATCGTCACAGCCCATGCAT +TTGTAATAATCTTCTTCATAGTAATACCCATCATAATCGGAGGCTTTGGCAACTGACTAGTTCCCCTAAT +AATCGGTGCCCCCGATATGGCGTTTCCCCGCATAAACAACATAAGCTTCTGACTCTTACCTCCCTCTCTC +CTACTCCTGCTCGCATCTGCTATAGTGGAGGCCGGAGCAGGAACAGGTTGAACAGTCTACCCTCCCTTAG +CAGGGAACTACTCCCACCCTGGAGCCTCCGTAGACCTAACCATCTTCTCCTTACACCTAGCAGGTGTCTC +CTCTATCTTAGGGGCCATCAATTTCATCACAACAATTATCAATATAAAACCCCCTGCCATAACCCAATAC +CAAACGCCCCTCTTCGTCTGATCCGTCCTAATCACAGCAGTCCTACTTCTCCTATCTCTCCCAGTCCTAG +CTGCTGGCATCACTATACTACTAACAGACCGCAACCTCAACACCACCTTCTTCGACCCCGCCGGAGGAGG +AGACCCCATTCTATACCAACACCTATTCTGATTTTTCGGTCACCCTGAAGTTTATATTCTTATCCTACCA +GGCTTCGGAATAATCTCCCATATTGTAACTTACTACTCCGGAAAAAAAGAACCATTTGGATACATAGGTA +TGGTCTGAGCTATGATATCAATTGGCTTCCTAGGGTTTATCGTGTGAGCACACCATATATTTACAGTAGG +AATAGACGTAGACACACGAGCATATTTCACCTCCGCTACCATAATCATCGCTATCCCCACCGGCGTCAAA +GTATTTAGCTGACTCGCCACACTCCACGGAAGCAATATGAAATGATCTGCTGCAGTGCTCTGAGCCCTAG +GATTCATCTTTCTTTTCACCGTAGGTGGCCTGACTGGCATTGTATTAGCAAACTCATCACTAGACATCGT +ACTACACGACACGTACTACGTTGTAGCCCACTTCCACTATGTCCTATCAATAGGAGCTGTATTTGCCATC +ATAGGAGGCTTCATTCACTGATTTCCCCTATTCTCAGGCTACACCCTAGACCAAACCTACGCCAAAATCC +ATTTCACTATCATATTCATCGGCGTAAATCTAACTTTCTTCCCACAACACTTTCTCGGCCTATCCGGAAT +GCCCCGACGTTACTCGGACTACCCCGATGCATACACCACATGAAACATCCTATCATCTGTAGGCTCATTC +ATTTCTCTAACAGCAGTAATATTAATAATTTTCATGATTTGAGAAGCCTTCGCTTCGAAGCGAAAAGTCC +TAATAGTAGAAGAACCCTCCATAAACCTGGAGTGACTATATGGATGCCCCCCACCCTACCACACATTCGA +AGAACCCGTATACATAAAATCTAGACAAAAAAGGAAGGAATCGAACCCCCCAAAGCTGGTTTCAAGCCAA +CCCCATGGCCTCCATGACTTTTTCAAAAAGGTATTAGAAAAACCATTTCATAACTTTGTCAAAGTTAAAT +TATAGGCTAAATCCTATATATCTTAATGGCACATGCAGCGCAAGTAGGTCTACAAGACGCTACTTCCCCT +ATCATAGAAGAGCTTATCACCTTTCATGATCACGCCCTCATAATCATTTTCCTTATCTGCTTCCTAGTCC +TGTATGCCCTTTTCCTAACACTCACAACAAAACTAACTAATACTAACATCTCAGACGCTCAGGAAATAGA +AACCGTCTGAACTATCCTGCCCGCCATCATCCTAGTCCTCATCGCCCTCCCATCCCTACGCATCCTTTAC +ATAACAGACGAGGTCAACGATCCCTCCCTTACCATCAAATCAATTGGCCACCAATGGTACTGAACCTACG +AGTACACCGACTACGGCGGACTAATCTTCAACTCCTACATACTTCCCCCATTATTCCTAGAACCAGGCGA +CCTGCGACTCCTTGACGTTGACAATCGAGTAGTACTCCCGATTGAAGCCCCCATTCGTATAATAATTACA +TCACAAGACGTCTTGCACTCATGAGCTGTCCCCACATTAGGCTTAAAAACAGATGCAATTCCCGGACGTC +TAAACCAAACCACTTTCACCGCTACACGACCGGGGGTATACTACGGTCAATGCTCTGAAATCTGTGGAGC +AAACCACAGTTTCATGCCCATCGTCCTAGAATTAATTCCCCTAAAAATCTTTGAAATAGGGCCCGTATTT +ACCCTATAGCACCCCCTCTACCCCCTCTAGAGCCCACTGTAAAGCTAACTTAGCATTAACCTTTTAAGTT +AAAGATTAAGAGAACCAACACCTCTTTACAGTGAAATGCCCCAACTAAATACTACCGTATGGCCCACCAT +AATTACCCCCATACTCCTTACACTATTCCTCATCACCCAACTAAAAATATTAAACACAAACTACCACCTA +CCTCCCTCACCAAAGCCCATAAAAATAAAAAATTATAACAAACCCTGAGAACCAAAATGAACGAAAATCT +GTTCGCTTCATTCATTGCCCCCACAATCCTAGGCCTACCCGCCGCAGTACTGATCATTCTATTTCCCCCT +CTATTGATCCCCACCTCCAAATATCTCATCAACAACCGACTAATCACCACCCAACAATGACTAATCAAAC +TAACCTCAAAACAAATGATAACCATACACAACACTAAAGGACGAACCTGATCTCTTATACTAGTATCCTT +AATCATTTTTATTGCCACAACTAACCTCCTCGGACTCCTGCCTCACTCATTTACACCAACCACCCAACTA +TCTATAAACCTAGCCATGGCCATCCCCTTATGAGCGGGCACAGTGATTATAGGCTTTCGCTCTAAGATTA +AAAATGCCCTAGCCCACTTCTTACCACAAGGCACACCTACACCCCTTATCCCCATACTAGTTATTATCGA +AACCATCAGCCTACTCATTCAACCAATAGCCCTGGCCGTACGCCTAACCGCTAACATTACTGCAGGCCAC +CTACTCATGCACCTAATTGGAAGCGCCACCCTAGCAATATCAACCATTAACCTTCCCTCTACACTTATCA +TCTTCACAATTCTAATTCTACTGACTATCCTAGAAATCGCTGTCGCCTTAATCCAAGCCTACGTTTTCAC +ACTTCTAGTAAGCCTCTACCTGCACGACAACACATAATGACCCACCAATCACATGCCTATCATATAGTAA +AACCCAGCCCATGACCCCTAACAGGGGCCCTCTCAGCCCTCCTAATGACCTCCGGCCTAGCCATGTGATT +TCACTTCCACTCCATAACGCTCCTCATACTAGGCCTACTAACCAACACACTAACCATATACCAATGATGG +CGCGATGTAACACGAGAAAGCACATACCAAGGCCACCACACACCACCTGTCCAAAAAGGCCTTCGATACG +GGATAATCCTATTTATTACCTCAGAAGTTTTTTTCTTCGCAGGATTTTTCTGAGCCTTTTACCACTCCAG +CCTAGCCCCTACCCCCCAATTAGGAGGGCACTGGCCCCCAACAGGCATCACCCCGCTAAATCCCCTAGAA +GTCCCACTCCTAAACACATCCGTATTACTCGCATCAGGAGTATCAATCACCTGAGCTCACCATAGTCTAA +TAGAAAACAACCGAAACCAAATAATTCAAGCACTGCTTATTACAATTTTACTGGGTCTCTATTTTACCCT +CCTACAAGCCTCAGAGTACTTCGAGTCTCCCTTCACCATTTCCGACGGCATCTACGGCTCAACATTTTTT +GTAGCCACAGGCTTCCACGGACTTCACGTCATTATTGGCTCAACTTTCCTCACTATCTGCTTCATCCGCC +AACTAATATTTCACTTTACATCCAAACATCACTTTGGCTTCGAAGCCGCCGCCTGATACTGGCATTTTGT +AGATGTGGTTTGACTATTTCTGTATGTCTCCATCTATTGATGAGGGTCTTACTCTTTTAGTATAAATAGT +ACCGTTAACTTCCAATTAACTAGTTTTGACAACATTCAAAAAAGAGTAATAAACTTCGCCTTAATTTTAA +TAATCAACACCCTCCTAGCCTTACTACTAATAATTATTACATTTTGACTACCACAACTCAACGGCTACAT +AGAAAAATCCACCCCTTACGAGTGCGGCTTCGACCCTATATCCCCCGCCCGCGTCCCTTTCTCCATAAAA +TTCTTCTTAGTAGCTATTACCTTCTTATTATTTGATCTAGAAATTGCCCTCCTTTTACCCCTACCATGAG +CCCTACAAACAACTAACCTGCCACTAATAGTTATGTCATCCCTCTTATTAATCATCATCCTAGCCCTAAG +TCTGGCCTATGAGTGACTACAAAAAGGATTAGACTGAACCGAATTGGTATATAGTTTAAACAAAACGAAT +GATTTCGACTCATTAAATTATGATAATCATATTTACCAAATGCCCCTCATTTACATAAATATTATACTAG +CATTTACCATCTCACTTCTAGGAATACTAGTATATCGCTCACACCTCATATCCTCCCTACTATGCCTAGA +AGGAATAATACTATCGCTGTTCATTATAGCTACTCTCATAACCCTCAACACCCACTCCCTCTTAGCCAAT +ATTGTGCCTATTGCCATACTAGTCTTTGCCGCCTGCGAAGCAGCGGTGGGCCTAGCCCTACTAGTCTCAA +TCTCCAACACATATGGCCTAGACTACGTACATAACCTAAACCTACTCCAATGCTAAAACTAATCGTCCCA +ACAATTATATTACTACCACTGACATGACTTTCCAAAAAACACATAATTTGAATCAACACAACCACCCACA +GCCTAATTATTAGCATCATCCCTCTACTATTTTTTAACCAAATCAACAACAACCTATTTAGCTGTTCCCC +AACCTTTTCCTCCGACCCCCTAACAACCCCCCTCCTAATACTAACTACCTGACTCCTACCCCTCACAATC +ATGGCAAGCCAACGCCACTTATCCAGTGAACCACTATCACGAAAAAAACTCTACCTCTCTATACTAATCT +CCCTACAAATCTCCTTAATTATAACATTCACAGCCACAGAACTAATCATATTTTATATCTTCTTCGAAAC +CACACTTATCCCCACCTTGGCTATCATCACCCGATGAGGCAACCAGCCAGAACGCCTGAACGCAGGCACA +TACTTCCTATTCTACACCCTAGTAGGCTCCCTTCCCCTACTCATCGCACTAATTTACACTCACAACACCC +TAGGCTCACTAAACATTCTACTACTCACTCTCACTGCCCAAGAACTATCAAACTCCTGAGCCAACAACTT +AATATGACTAGCTTACACAATAGCTTTTATAGTAAAGATACCTCTTTACGGACTCCACTTATGACTCCCT +AAAGCCCATGTCGAAGCCCCCATCGCTGGGTCAATAGTACTTGCCGCAGTACTCTTAAAACTAGGCGGCT +ATGGTATAATACGCCTCACACTCATTCTCAACCCCCTGACAAAACACATAGCCTACCCCTTCCTTGTACT +ATCCCTATGAGGCATAATTATAACAAGCTCCATCTGCCTACGACAAACAGACCTAAAATCGCTCATTGCA +TACTCTTCAATCAGCCACATAGCCCTCGTAGTAACAGCCATTCTCATCCAAACCCCCTGAAGCTTCACCG +GCGCAGTCATTCTCATAATCGCCCACGGGCTTACATCCTCATTACTATTCTGCCTAGCAAACTCAAACTA +CGAACGCACTCACAGTCGCATCATAATCCTCTCTCAAGGACTTCAAACTCTACTCCCACTAATAGCTTTT +TGATGACTTCTAGCAAGCCTCGCTAACCTCGCCTTACCCCCCACTATTAACCTACTGGGAGAACTCTCTG +TGCTAGTAACCACGTTCTCCTGATCAAATATCACTCTCCTACTTACAGGACTCAACATACTAGTCACAGC +CCTATACTCCCTCTACATATTTACCACAACACAATGGGGCTCACTCACCCACCACATTAACAACATAAAA +CCCTCATTCACACGAGAAAACACCCTCATGTTCATACACCTATCCCCCATTCTCCTCCTATCCCTCAACC +CCGACATCATTACCGGGTTTTCCTCTTGTAAATATAGTTTAACCAAAACATCAGATTGTGAATCTGACAA +CAGAGGCTTACGACCCCTTATTTACCGAGAAAGCTCACAAGAACTGCTAACTCATGCCCCCATGTCTAAC +AACATGGCTTTCTCAACTTTTAAAGGATAACAGCTATCCATTGGTCTTAGGCCCCAAAAATTTTGGTGCA +ACTCCAAATAAAAGTAATAACCATGCACACTACTATAACCACCCTAACCCTGACTTCCCTAATTCCCCCC +ATCCTTACCACCCTCGTTAACCCTAACAAAAAAAACTCATACCCCCATTATGTAAAATCCATTGTCGCAT +CCACCTTTATTATCAGTCTCTTCCCCACAACAATATTCATGTGCCTAGACCAAGAAGTTATTATCTCGAA +CTGACACTGAGCCACAACCCAAACAACCCAGCTCTCCCTAAGCTTCAAACTAGACTACTTCTCCATAATA +TTCATCCCTGTAGCATTGTTCGTTACATGGTCCATCATAGAATTCTCACTGTGATATATAAACTCAGACC +CAAACATTAATCAGTTCTTCAAATATCTACTCATCTTCCTAATTACCATACTAATCTTAGTTACCGCTAA +CAACCTATTCCAACTGTTCATCGGCTGAGAGGGCGTAGGAATTATATCCTTCTTGCTCATCAGTTGATGA +TACGCCCGAGCAGATGCCAACACAGCAGCCATTCAAGCAATCCTATACAACCGTATCGGCGATATCGGTT +TCATCCTCGCCTTAGCATGATTTATCCTACACTCCAACTCATGAGACCCACAACAAATAGCCCTTCTAAA +CGCTAATCCAAGCCTCACCCCACTACTAGGCCTCCTCCTAGCAGCAGCAGGCAAATCAGCCCAATTAGGT +CTCCACCCCTGACTCCCCTCAGCCATAGAAGGCCCCACCCCAGTCTCAGCCCTACTCCACTCAAGCACTA +TAGTTGTAGCAGGAATCTTCTTACTCATCCGCTTCCACCCCCTAGCAGAAAATAGCCCACTAATCCAAAC +TCTAACACTATGCTTAGGCGCTATCACCACTCTGTTCGCAGCAGTCTGCGCCCTTACACAAAATGACATC +AAAAAAATCGTAGCCTTCTCCACTTCAAGTCAACTAGGACTCATAATAGTTACAATCGGCATCAACCAAC +CACACCTAGCATTCCTGCACATCTGTACCCACGCCTTCTTCAAAGCCATACTATTTATGTGCTCCGGGTC +CATCATCCACAACCTTAACAATGAACAAGATATTCGAAAAATAGGAGGACTACTCAAAACCATACCTCTC +ACTTCAACCTCCCTCACCATTGGCAGCCTAGCATTAGCAGGAATACCTTTCCTCACAGGTTTCTACTCCA +AAGACCACATCATCGAAACCGCAAACATATCATACACAAACGCCTGAGCCCTATCTATTACTCTCATCGC +TACCTCCCTGACAAGCGCCTATAGCACTCGAATAATTCTTCTCACCCTAACAGGTCAACCTCGCTTCCCC +ACCCTTACTAACATTAACGAAAATAACCCCACCCTACTAAACCCCATTAAACGCCTGGCAGCCGGAAGCC +TATTCGCAGGATTTCTCATTACTAACAACATTTCCCCCGCATCCCCCTTCCAAACAACAATCCCCCTCTA +CCTAAAACTCACAGCCCTCGCTGTCACTTTCCTAGGACTTCTAACAGCCCTAGACCTCAACTACCTAACC +AACAAACTTAAAATAAAATCCCCACTATGCACATTTTATTTCTCCAACATACTCGGATTCTACCCTAGCA +TCACACACCGCACAATCCCCTATCTAGGCCTTCTTACGAGCCAAAACCTGCCCCTACTCCTCCTAGACCT +AACCTGACTAGAAAAGCTATTACCTAAAACAATTTCACAGCACCAAATCTCCACCTCCATCATCACCTCA +ACCCAAAAAGGCATAATTAAACTTTACTTCCTCTCTTTCTTCTTCCCACTCATCCTAACCCTACTCCTAA +TCACATAACCTATTCCCCCGAGCAATCTCAATTACAATATATACACCAACAAACAATGTTCAACCAGTAA +CTACTACTAATCAACGCCCATAATCATACAAAGCCCCCGCACCAATAGGATCCTCCCGAATCAACCCTGA +CCCCTCTCCTTCATAAATTATTCAGCTTCCTACACTATTAAAGTTTACCACAACCACCACCCCATCATAC +TCTTTCACCCACAGCACCAATCCTACCTCCATCGCTAACCCCACTAAAACACTCACCAAGACCTCAACCC +CTGACCCCCATGCCTCAGGATACTCCTCAATAGCCATCGCTGTAGTATATCCAAAGACAACCATCATTCC +CCCTAAATAAATTAAAAAAACTATTAAACCCATATAACCTCCCCCAAAATTCAGAATAATAACACACCCG +ACCACACCGCTAACAATCAATACTAAACCCCCATAAATAGGAGAAGGCTTAGAAGAAAACCCCACAAACC +CCATTACTAAACCCACACTCAACAGAAACAAAGCATACATCATTATTCTCGCACGGACTACAACCACGAC +CAATGATATGAAAAACCATCGTTGTATTTCAACTACAAGAACACCAATGACCCCAATACGCAAAACTAAC +CCCCTAATAAAATTAATTAACCACTCATTCATCGACCTCCCCACCCCATCCAACATCTCCGCATGATGAA +ACTTCGGCTCACTCCTTGGCGCCTGCCTGATCCTCCAAATCACCACAGGACTATTCCTAGCCATGCACTA +CTCACCAGACGCCTCAACCGCCTTTTCATCAATCGCCCACATCACTCGAGACGTAAATTATGGCTGAATC +ATCCGCTACCTTCACGCCAATGGCGCCTCAATATTCTTTATCTGCCTCTTCCTACACATCGGGCGAGGCC +TATATTACGGATCATTTCTCTACTCAGAAACCTGAAACATCGGCATTATCCTCCTGCTTGCAACTATAGC +AACAGCCTTCATAGGCTATGTCCTCCCGTGAGGCCAAATATCATTCTGAGGGGCCACAGTAATTACAAAC +TTACTATCCGCCATCCCATACATTGGGACAGACCTAGTTCAATGAATCTGAGGAGGCTACTCAGTAGACA +GTCCCACCCTCACACGATTCTTTACCTTTCACTTCATCTTGCCCTTCATTATTGCAGCCCTAGCAACACT +CCACCTCCTATTCTTGCACGAAACGGGATCAAACAACCCCCTAGGAATCACCTCCCATTCCGATAAAATC +ACCTTCCACCCTTACTACACAATCAAAGACGCCCTCGGCTTACTTCTCTTCCTTCTCTCCTTAATGACAT +TAACACTATTCTCACCAGACCTCCTAGGCGACCCAGACAATTATACCCTAGCCAACCCCTTAAACACCCC +TCCCCACATCAAGCCCGAATGATATTTCCTATTCGCCTACACAATTCTCCGATCCGTCCCTAACAAACTA +GGAGGCGTCCTTGCCCTATTACTATCCATCCTCATCCTAGCAATAATCCCCATCCTCCATATATCCAAAC +AACAAAGCATAATATTTCGCCCACTAAGCCAATCACTTTATTGACTCCTAGCCGCAGACCTCCTCATTCT +AACCTGAATCGGAGGACAACCAGTAAGCTACCCTTTTACCATCATTGGACAAGTAGCATCCGTACTATAC +TTCACAACAATCCTAATCCTAATACCAACTATCTCCCTAATTGAAAACAAAATACTCAAATGGGCCTGTC +CTTGTAGTATAAACTAATACACCAGTCTTGTAAACCGGAGATGAAAACCTTTTTCCAAGGACAAATCAGA +GAAAAAGTCTTTAACTCCACCATTAGCACCCAAAGCTAAGATTCTAATTTAAACTATTCTCTGTTCTTTC +ATGGGGAAGCAGATTTGGGTACCACCCAAGTATTGACTCACCCATCAACAACCGCTATGTATTTCGTACA +TTACTGCCAGCCACCATGAATATTGTACGGTACCATAAATACTTGACCACCTGTAGTACATAAAAACCCA +ATCCACATCAAAACCCCCTCCCCATGCTTACAAGCAAGTACAGCAATCAACCCTCAACTATCACACATCA +ACTGCAACTCCAAAGCCACCCCTCACCCACTAGGATACCAACAAACCTACCCACCCTTAACAGTACATAG +TACATAAAGCCATTTACCGTACATAGCACATTACAGTCAAATCCCTTCTCGTCCCCATGGATGACCCCCC +TCAGATAGGGGTCCCTTGACCACCATCCTCCGTGAAATCAATATCCCGCACAAGAGTGCTACTCTCCTCG +CTCCGGGCCCATAACACTTGGGGGTAGCTAAAGTGAACTGTATCCGACATCTGGTTCCTACTTCAGGGTC +ATAAAGCCTAAATAGCCCACACGTTCCCCTTAAATAAGACATCACGATG diff -r 000000000000 -r 711d4deb7bdf test-data/consensus.hdf Binary file test-data/consensus.hdf has changed diff -r 000000000000 -r 711d4deb7bdf tool_data_table_conf.xml.sample --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool_data_table_conf.xml.sample Sat May 23 13:37:48 2020 -0400 @@ -0,0 +1,7 @@ + + + + value, dbkey, name, path + +
+
\ No newline at end of file diff -r 000000000000 -r 711d4deb7bdf tool_data_table_conf.xml.test --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool_data_table_conf.xml.test Sat May 23 13:37:48 2020 -0400 @@ -0,0 +1,7 @@ + + + + value, dbkey, name, path + +
+
\ No newline at end of file
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++ 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++ 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++ 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++ 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+GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCCGCCTCTCCTGGTCTCATGGGCTCGGAGATGTGTATAAGAGACAGAAGCGCTGGGCTGTGTGCACGAACCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTGCAGGTCAACCCGGTAGGGCGACAAGCGCCACTGGCGGCAGCCATTGGTAAAAGTCGATGTGCGAGAGGTTCAGAGAGTACTTGAAGTGATGGCCTGACTACAGCTACACTGAAAGGACAGTTTTGGTGGCTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGTTCCCCAACTGACTTAACCTTCGATCAAACCACCTCCCCAGGTGTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACGCAATAATCACAAGAAGAAACTCCGACAAACTGGTTAAAATCAATCCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTGGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAAACCAAGTTTAAACATGATAAAGATATCCACTTAAAAAATTTTAAGTGTTTCGAAGAGCATAACTCTCAAACAACTAAAAAGCTTACTTAATGTAATATCCTGAAAAAACAACTTTGGGAAAACATCGATATTAGACACGATATTTCCATTTTATGACGTAAAACCCAGCAGCTCTGTTAAAGTAAAAAAGCTTTAGAAATGAAGCATCTCTTTTAAATAAAAGAAAACTCATTTGGGATAGCTATTTACATAACATGGACACATCAAAGAAATGTCCATAACAATAAGAGATGAAGGTCAGAGTAACACAAAATACTCAACGATAGATAACACACAAAGTGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCTCATTGCGACAAACCCTCGGCTCTCAGGGGAAAAGAGGGGAATGTTTTAATGATTAAGGTTAGTGAAACACAGAACGGAAAAAGAACCCCCCAGAAGAATTGATTACTATAAAATAACACAAAAGCACAAAGAAATAAACGGAGAAATAAAACAAACTAAAAGGTAAGCTATATGAATTCAAAACCGCAGCGATAATAACCACATCCAAGAAACATAAACAAAGAAACAACGATAAAAAACGTATCAAAACTACTAACACAAAAAAGAAAAGATGAAATATTAGGCAACCTAAAGAATAGATAATAGAATTAACGATATTGCAATAATAACCCAACAGATCAAAACAAAGAGAGATTTTTTTTTTTTAGATATAGGACTAAGTGAATTAAATGAAATATCAATGTGGTGAAGGTAAACAGAGCGCATCTTTCGATAGCTCAATCTTAGTTCAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAAATTCATTACTCAGTAATCAAAGATATGATCAACGCTTTGATAGAAGCAGCAAAAACCAATAATAATCAAATATTTACAACAACGCACAGCTTCATGATGTAATATGTGCGATAAACGAATTAGATGAAAAAGAAAGATATATCTTACATAAGACTGGGAAGAGACAAGGAATCTCAAAAACCTACAGCAATGCAATTTAACATGGATGATTTTTCTTTTCAGTTGAAAATGGCTGGGAGGTGAGATAAATGAAACCGAGAAAAATAAATGATTATAAAAAGTCATTTTTCGTTGAGGGTGATGATGATTTCACTTCCTTTTGCAATCTACTTGAAATAGAAGGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAAACAAACAAACCCTTAGAGCATTTAAAAGCATAGAGTCTTTTAATGAAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACCAAGCTCGCATAATGGGAAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCAGGAAAAAACAAGAATAGCGCAATAGAAGATCTAATCATTGCTCACGCGTGTAAAAAGAAGAGGTGTTTAGATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCTGGAACAACACCCAAATAATGAAAGAAAGCAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACAGTGAAGCTGCTTCAGTGAGATAAAAATTTATATCAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAGAGATGTTTTACCCAGGAAAACGGGAAGGATGCGTCAGGATCGTTTTCAACTCCTTTCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAATTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCCAGCACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCGAGAGCTGCCGCCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTCTGATTTCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCATAAAACATGGCTCCGTATCTGACATGGGTGTCGGAGGCAAAGCCTGACCAGGGCAATTGTAATAGCGTGCATGTATGCGCGGTATAGCAATTACATCCTGTCCTGTCAACAAGCTCGGATTACCGACAAAGGCACGGCAGTTTTGGCAGTGACGGTGTTTGTCTGACCAGAAATGCCGTCAAAAAAGCCAAGCGGCAGAATAACGGCAACAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACAGAACAGGAGAAAACGAAAAGATGAACAAGCAGCAAGCCGTACTCAACATGGCGGGATTCATAAAAGTCAGAGCCTGACGCTGCTCAAAAAAACTGGACACGCGATGCTGACGAACGAAAGGCTGCCATGTGTGAGAAGCTGCACGAACTCGCAGAAGAACTCCAGAACAGCATCAGACACGCTTTGAAGTAGAAAATGGCACAGAGAGATAACGCTCAGGCTGTCTCTTATACACATCTGACGCTGCCGACGACAGAGTGCGCGCGCAGCGGTACGTAACC ++ +/34212137>>C3/(.<:/-1:58=+369A=8-%4&&$,,-'+48:9:CA'8.3HG::250?;B3$14?D+,91:53))9.1'0=>88D;;9,7>=C:<:863140+:8=87BAFDEEE5/,+16?=?J<@F:6.10+)+2.)$.1-A67;?;+0*%/'%-64256)58?=H88:>>$-1/-(,137256?C?:4;8826)+8?65@?BC@@>)'.%%'0@>CAC>@C?C*(A?53<=>E?:<<-,(5;<>@6>,,:;:;3>3/C=70636&+33?A2:<9@<>A>=%%79B:88EBB=DC98856B?@8<>8,20;B@:55:;>3=AFH;@2:@AACI:775(;8AF:C6DAJKA=?24>@COH70>:;99D?AD)<&@>7:E?CFEBBEG>B82'3958;;CB>:;>DEB><:8/'$)*+51.5D:?BA@>:=85<5,::03<9D=/0,14))((,*)$6)*)GJEHMIB:CA?;;<%,?FA6691+,0@@D:7CEGK@016=978.1*)%#'$)-.67<=5,7.0><23-6=@67%'$$$6//2@B23:67DNRKA4A@?**5;4;:25DHAB=<:;;89;6687%*)&$,/5:*=6;;=:>=>964467>07<3:0384@A<83DDBF<96AD3-**))01288A>A9;347ECB?=@:*BE?%+38DI@B7?BBB7:AE:DA<;;G+.'521.';<97@?@A;?ACBD<()6:A.7+>?;;B9:6;?B1/??<;4A9:2:;5@99::=<9:97?4568:=<8ACEE??/6'5-.2*2.<I?9;>5=?>91;3B8.%.2,,0).'2==D>A@@@467BB>A:DG0EE>>43A/2A=G>@<:B:048@JD6'CGHHQE@,A-FI:@C=DBAEG=CGF?=?<@=>=AE9MPF:=HG&/'.&9&&<8A:CEFFBC0+=(%1133649*$+===D7LQA6*%.5:;*44-11@=-:&)((*49:=+401**,A;A8HA7:B=8;EDFAB@>B78?@14;>8))*()(66::@JCD=DDEF<3IJ/'-#*-*<@HAJHFA@@>;9:E;885A@D::@C7>@;:00=?EAEBTLF3-8*+('*$&:;9<.)114$969//(&$.9:;?3@=:===.5@B<;+-+/,:=@G<9::E=.-C@@<7-.+6B@CE99=@BI907@BB?BDD)(@DA<9/)?:8//++/AAA:768;?IG?9:2AA;>>IEEH>555(((-0121-''(6<=?14:'+/7&=99;6,3-/56?A:;67FC@B;899561@@>DFM??D>=<@GDBAFJOKC-8?H?@;=KGDDPMMG?@8=58C>:AC??@ID,F@-7'0-78>><;<@@BEBDCBFDGE?=GHA1,1=FEEIXKB:8B<84743;777.,1/2A<1>812A8:??DD2A9;9<@-&/-6&?@<:7EL?6E7/1:<>83@6EFBE<=JC55NQ@@B=@9978'.;353-8*$%*<=@B?>:99RLOIEHAA@<;9&<;@77B@ADDHC@DFI??@A888LAHD?D=9:A=A=JHRCC?HCF9;9=.6(75/:7:<2227AF::?77:DEEC78@GGFAA:3AIJ=34@)(>@A6?21*)9B>??)($+0,,8<9;7.:@BA;/3:;866'BB@IHFC>AFEC@DCC41<3..;:3BBEHTKIA9?B6>=+%2::?864$$147=7;;A@8;=>A?AF965;<6;-(78-(&&85,,16?=ACE//A?<((;>5%%8;?CCB==<;@DFF=HTL'<=B:C=2CE=A=7<-%%*9>B78>8<>??KLJF<><=:C$-B@;4AEFB=HG>*-9:>>33337/6061134945.'6A=92;9A=;:,*;A;((=:@<97@67=@CN/?E>GJM><8545=;920884-&&211-(:@?=@9<95DCD6EB?@9+59=@D@=>>JMFGG@@4:/B;=,,=><>?C=G9=CD?E=?@?8+++.B86@9;84832:78A5=;>:;EIHMDCCG@B-*26??..33>;D?B@BOM?*=<>A<88AB48B;93=65770')%)''+044006:C=?0++;===B=CEBI@=:?64;A?EC@I8?(>%+?;@4=;FB8?+),333586;>DFIJE?E:DGEC:>9%%*#%/%0')..-,1146$$C@9;=555*9%+-.1B@7?BBH?KO;B8CTKG?<>GIIIFA@>8:8:A7@09%%%E?>:98$'5@A&&,D>B;0DEC@*/2<>;B>9867<:%)CCEAG@57/40<&.>?@=%>G4F>?@628@C=:9:?@B;8=BAHK*?*;A?DFB=KIGF@6:C?D?EA?@>D97A9?ACD@2=<.5*==>DDAFE@DFBFHFC:?CB;=:9:5.,37GG@9D99BD9A?;=<>1))8,7>9B/DAD7-142G948&($(+61413;6054&))**+3&(&*67=?4/A++9-/,A6D8?83C9:ACJ7:86,,*%449?9FBAC>C/7%%448:5691539$''1:=;*95?>=2<9CI;D?=%%)9-;--..;//;6./*384-+'(%56/B<@@?CDA:<<82&.9..,8/&)@?G99:894<5DE:B3-?/A:<@E*/)-57B;8))-& +@97804cb9-0ad5-4f2e-abd6-de8c42002abd +GTTACTTCGTTCCGGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCAGCGTCAGATGTATAAGAGACAGGAACATGGCGGGCAAAGCAAAGCACCGGAGGAAGCCAGCGCCGCAGGCGTTTTTCCATAGGCTCCGCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGCCAGGGTGGCGAAACCCGATGGGACTATAAAAAGATGGTGTTTCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCTTCGGGAAGCGTGGCGCTTTCTCGCAGCTCACGCTGTAGGTATCTCGGTTCGGTGTGAGTCATTTCGCTCAAGCTGGGCTGTGTGCACGAACCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCATGAGTCCAACCCGGTAGGGCTTGCGACAAAGCGCCACTGGCAGCAGCCGATGGTAAAAGTCGATGTGCAGGGAGTTGATGCGGAAGTGATGGCCTGACTACAGCTACACTGAAAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCAGCTCCCCAACTGACTTAACCTTCGATCAAACCACCTCCCCAGGTGGTTTTCGTTTTCAGTTTAGGAGATTACGACCAGAACACAATAATCACAAGGAAGAAACTCCGACAAACTGGTTAAAATCAATCAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAAGAAACAGTGGCATAGTGATGCATAGAAATAAACACATTATTACTATGTAAACGTAAACAGAAATGGAGAGCAAGTTTAAACAGTCAAAGATATCCATAAAAAATTTTAAGTGTTTCGAGAACATAACTCTCAAACAACTAAAAACACTTAATGTAATATCGGAAAAAACAACTTTGGGAAAACATCGATATTAGACGCGATATTTTCATTTTTATGACGTAAAAACCCAGCAGCTCTGTTAAAAGTAAAAAGCTTTGAAAATGAAGCATCTCTTTTAAATAAAAGAAAACTCATTTGGGATAGCTATTTTTATAACATGGACACATCAAAGAAAATGTCATAACAATAAGAGATGAAGGTCAAGTAACACAAAATACTCAACGATAAGATAACACAAAGTGAATCAAAGCGTGTCCACTCATGTTGAGTCAATATTATCAAACACCCCTCCATTGCGACAAACCCTCGGCTCTCAGGAAAAGAGGGAATGTTTAATGATTAGGTTAGTGAAACACAGAACGGAAAAAAGAACCCCCCAGAAGAATTGGTCACTATAAAAATAACACAAAAAGCACAAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAGCTATATGAATTCAAAACCGCAGCGATAATATACATCCAAGAAACATAAACAAAAGAAGCGATAAAACGTATCCATTATAACACAAAAAGAAAACAAATAATAGGCAACCTAAAAGAATGAATGTAAATTAACGATATTGCAATAATAGCAACAGATCAACAAGAGATTTTTTAGATATAGGACTAAATGAATTAAATAGAAATATGTGCTTGGTGAAGGAAGCTAAGCAGAGCGCTTTATCTTGAAGTAGCTCAATCTTAGTTCAAAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTACTCAGTAATCAAGATATGATCAACACTTTTGATAGAAGTAGCCTTAAAAACCAATAATAATCAAATATTTACAACAACACACAGCCATGATGTAATATGTGCGATAAGCGAATTAGATGAAAAAGAAAAAGATATATCTTACATAAGACTGGGAAGAGACAAAGAAGTCTCAAAAGCCTACAGCAATGCAATTTAACATGGATGATTTTTTCTTTTTCAGTTAGAAAATGGCGCTGGGAGGTGAGATAAGTGAAACCGAGAAAAATAAATGATTTATAAAAGTCATTTTCGTTGGGGGTGATGATGATTTTCACTTCCTTTGCAATCTACTTGAAATAGAAGAATTAATGATGTTTATGTTGAAAAAATAAATGGAAAGACAAAACTAAAACAAACCCTTAGAGCATTTAAAGCATAGAGTCTTTTAGTAAAAGAAAGTATATTCTTAATCATCGATGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGGGCTTAACATTTCATCACCAAGCTCGCATAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATGCCGGAAAAAACAAGAATAGCGCAATAGAAGATCTAATCATTGCTCACGCGTGTAAGAAGAAGGTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAAAGTCTATTATTACATCCTTAGATCCTGAAAGTTAAAAACACCCAAATAATGAAAAGAAAGCAAAGAAGTTCAAGTTTACCTTAGTTGTAATAAGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACTGATGACTTTACTTCAATGAGATAAAAGAATTTATATCAAAAAATATGAAACAACTCCACCTACGAAATCATAAGCCTAATGTTAAAGACAATTATAAAATTTAACATAATGCTGTGGTGTACGCACCACGCTGAAACGCGCTGAACGCGATTTCTGACGCAGACACCGCAAAAGAAGAGATGTTTTACCGGGAAAACAGGAAGGATGCCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCCTTTTGGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACGGATTTTCTCTCCGGGAAACTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAACACCCTCACGCATACTCACAATACCATTACGCTTGCCCAATCGATAAGGGATTTTTCTGTAAGCTTGCCCCAGTCTCATAACTTCTTTCAATTACCCGATCATCAGTCCGTTTGAGTTAACTTTTTCTTACCGAGAGCTGCCGCCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAACAGCCCTTTTTCTGATTTCTGATGCTTCTTCTGCCCGTCAGACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTGTCATAAAACATGGCTCCGTATCTGACATGGGTGTGGGGCAGAAGCCCTGACCAGAACGAATGTAATAGCGTGCATGTATGCGCGGTATAACAATTGCACATCCTGTCCTGTCAGCAAGCTCGAATTACCGACAAGGCGCGGCAGTTTTTGGCAGTGACGGTGTTGTCTGACAGGAATGCCGTCAAAAAGCCAAGCGGCAAGAATAACGGCAACAAAACAGTCGAAAAAGTGGTACGCGATATAATCACACAACAAGCACGGATGACAGACAGAACGGGAAAACGGAAAGATGAACAAGCAGCAGCAAGCCGTACTCAACATGGCGGGATTCATAAAGTCAAGAGCCTGAGCGCTGCTCGAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTGCGAACTCGCAGAAGAACTCCAGAGACAGCATCAGACACGCTTTGAGAGTATGGAAAATAGCACAGAGAGATAACGCTCAGGACAGGATGCCGAACGGCACAACAGAGCGTAAGGAAAATGTCACATAAGGCGCTCTCTTCCGCTTTACCTCGCTCACTGACTCCGCGCTACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCAGCTCGCTCAAAAGCGGTAATACGGTTATCCACAGAATCAGGGATAAAGTCGGAAAAAGAACACTGTCTCATATACATCTGACGCTGCGCCGACGACAGAGTGCGCGCCACCAACAATAAATAAC ++ 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++ 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++ 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++ 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++ 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GAGAGAGTGTGGCAATACGTAAC ++ 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+GTTTTCGCCCGTTCTGATTACGTATTATTGCTGCGCACTCTCTCATAGTCGTGGGCTCGGAGATGTGTACTAGGGCTCAGATGACTTATTATTACTATGTAAACATCAAACGAAATGAAACCAGTTAAACTTTGATAAAAGATATCCACTTAAAGATTTTTAGTGTTTTGAGAGCATAACTCTCAAACAACTAAAACACCCAATGCTAATATCGGAAAAAACAACTTTGGGAAGAGCATCTGATATTAAGACCTGATATTTTCATTATGACGTAAAGGCAGCTGGCTCTGTTAAAAGTAAAAGGCTTTGATGACATCTCTTTTATCTGCTGTTGGGATGATAGCTATTTTTATAACTGGACACATCGAGAAATGTCATAACAATAAGAGATATGAAAGGTCAGAGAAGTAACACAAAAATACTCATTTGATAGATAACACACAAAGTAGAATCAAGCGTGTCCCTCAATGTTGAGTCAATATTATCAAACACCCCTCATTTGACAAACCCTCAGCTCTCAGGGGAAAAGAGGAATGTTGCATGATTGAGTTAGTGAAAACACAGGAACTGGAAAAGAACCCCAGAAGAGATTGATTACCTATACAAAAATAATATACCAAAGCACAAGAAATAAACGGAGAAATAAAACAAACTAAAAAGGTAAGCTATAGATTCAAACTGGCAATAATAACCACGTAAAGAGCACAAACAAAGCAGCGATAAAAAACGTATCAAAACTACTAACACAAAGAAAAGATGAAATAATAGGCAACCTAAAAGAATAAATATAGAATTAACGATGTACAATAATAGCAACAGATCAAAACAAAGATTTTTAGATATAGGACTAGAGTGAATTAAATGAAATATCTGATACTTGGTGAAGGAGTAAGCAGAGCGCTGTCTTTCATTAGCTCAATCTTAAGTTCAAAGACTCAATTATTCTCATTGATGAGATAGAAAATGGAATTCATTGCTCAGTAATCGGGACTATGATCAACGCTTTGATAGAAGCAGCAAAGCCAATAATAATCAAACCTTTTACAGCAACACAGCCATGATGTAATATGTACGATAAATGAGCTTGAATTAGATGAAAAAAGAAAAGATATATCTTACATATAAGACTAGGAAGAACAAAGGAATCTCAAAAACCTACAGCAATACAATTTAACATGGATGATTTTCATCCGGACAAGAAATGGCTGGGGTGAATAATGAAACCGAAAAATAAATGATTATAAAAAAGGTCATTTTCGTTGGGGAGTGATGATATTGATTTTCCACTTCCTTTTGCAATCTACTTTCTTCAGAAACTCTGTGAAGAAATTCAATGATGTTCCCATGTTGAAAAAATAAATGGAAAGATAAGAAACTAAAACAAACCCTTCTGAAACCCATTTAAAGCATAGAGTCTTTTTAATGAAAAGAAAGTATATTCTTAATCATCAGTGCCAATAGATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAAGCTTAACATTTCATCACAAGCTCGCGTAATGAAATAGCCATTAACAGGCTTACAAAATATCTTTCTTATCGCTTACCAGGAAAAAAACAAGAATGGCGCAATGGAAATCCCAATCATTTGCTCACGCGTATCTAAAGAAGAGGTGTTTAGATATATAGACGATCTATTCATTAAAATAAAAGAACAAGAATCTATTATTACATCCTTAGATCTGATTACAACACCCAAATATTAATAATGAAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAAGCAGGAATCAGATTCTAGAATAGGCATATCAATGAAAGAACAGAAACCATTGATGCAGTGGCTACTTGAGTGAGATAAAGAATTTATATCAAAGAAATATGGAAACAACTCCACCTACAAAATCCTTAAAAATTTTTAGCCATTCTGAACAATTAAGGTTAACAATGCTAGCAATTTGCTTTTTAACTCATAAAAGAGTGCGCTGAACACTGATTCCCAGGCGCAAGACACCGCAAAGAGATGTTTGCGGGAAAACAGGAAGGATCACGTCAGGATCGTTCTAGCTCGCTGCATGTAAGCAAGTGGAAATCACTGCAGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGAAGCTAATCTGCCATAAATGGATAACAGGGCACGGTACTCCGTAGTGCTTGATCAGCACCTCCGCATACTCCCTACTCTACCCGACACGCGCAGGTCGATAAAGTTTTCTGTAACGCCCCCAGTCTCAACTTCTTTCATTTTCCGATCGTGATCAATTGAAAGTTCATGCTTTGCCCACCAGGCTGCCTTCATAAAAGCTGAGCAGTCTTGCCGCATTCAACAGCCCTTTTTCTGATTCCTGGTCTTCTTCTGCGCCGTCAGACGAACTGAAAGGCGGCAGCTGATAATACCTTACGCGTATTACGCCCACTTCGTTTTGTCATAAAACACTTGGCTCCCGTATCAGCATGGGTGTCAGGAGCCACCAGAAAGCCCACGACCAGACACGAATTGCTAATAGCGTGCATATGCGCGGTATAACAATTACACATCCTATCCTGTCAATAAGCTCAATTTTAAACGAGGCACGGCAGTTTTTGGCAGTGACGGTGTTGTCTGACGAAATGCACCCGTCAAAAGCCAAGCGGCAGAATAACGGCAGCAAAACGGTCGAAAAGTGGTACGCGATGCCACCTATAATCACACAGCAACGCAGATGACAGACAGAACGGAGAAAACTGAAAAGATGAACAAGCAGCGGCGAAGCCCGTACCTCAACATGGCGGGATTCATAAAAGTCAAACCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTGAGAAACTGCACTGAACTCGCAGAACTCCAGAACAGCATCCAGACACACACTTGAAGTGAAAATAAGCACAGAGGAGATATAAGCATAGCGGGACAGGTGCCGAGCCTTTGTGAGCGCAAGGGAGAAATATCACATAACGGCTGCTCTCCTACGCTTCTACTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCGAAAGCTCACTCAAAAGCGGTATTACGGTTATCCACAGAATCAGGGGATACAAGTCGGAAAGAACATGTGAGCAAAAGCAAAGCACCGGAGGAAACCAGCGCGAACGTTTTCCATAGGCTCCGCCCCCTGGCCGAGCATCACAAAATCGACGCTCTGACCAGGGTGCGAAACCCGACAAGGACTATAAAGATACCGGGTCGCTTCCCCTGGAGGCTCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACGGATACCTGTCCGCCTTTCTCCTTCAGGAAGCGTGGCTTTCTCGCTGAAAAACTCACCGCATGCCGAAATTATCAGTTCGGTGTAGGTCGTTCACTCCAAACGTTTGTGCGAACCTACCCCATTCGAAGCGCCGACCGCTGCACCATATCAGTAACTATCGTCTTGAGTCCAACCCGGTAGACACGACAAAAGCACCACTGGCGGCAATACATTGGTAAAAGTCATTGAGAGGTTCAAGAGAGTACTGAAGTGATGGCCACAGCTACAGGCTTTACTGAAAGGACAGTTTGTGAGTGACTCGTCTCGCACAAGACAGTTACCTGAATTAAGCAGTTCCCCAACTGAAGCAACCTTCAGTGAAGCCACTCTCTACAGGTGGTTTTCGTTCAGTTTAAGGGAATTACGACCAGAACACAATAATCACAGAAGAAACTCCGACAAACTGGACAGAAGTAATCAAAACAGGACTATAAAGTAATATTATTTTGATTATACTTCTAGAAAGAAACAGTTAGCATAGTGATACATAAAATAAACACCTGTCTCTGCCTCTCAGGACCACAGGACAGAGTGCGCACTGTGGCTGTAGCAAC ++ 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++ 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cc1db555-a9ea-4585-acbb-2346cf88e42e +AATCATCCATGTTAAATTGCATTGCTGTAGGTTTTTGAGATTCCTTGTCTCTTCCCAGTCTTATGTAAGATATATCTTTTCTTTTTCATCTAATTCGTTTATCGCACATATTGCATCATGGCTGTAATGTTGTTGTAAATGTTGATTATTATTGGTTTTTTACTGCTTCTATCAAAGCGTTGATCATATCTTTGATTACTGAGTAATGAATTCTTTCTATCTCATCAATGAGAATAATTGAGTCTTTTTGAGCTAAGATTGAGCTAATGAAAGACAGCACTCTGCTTACTCCTTCACCAAGCATTGATATTTCATTTAATTCACTTAGTCTATCTAAAAAATCTCTTTGTTTTGATCTGTTGCTATTATTTAGTATCGTTAATTCTATTATCTATTCTTTTAGGTTGCCTATTATTTCATCTTTTCTTTTGTGTTAGTAGTTTTGATACGTTTTTATCGTTGCTTCTTTATTTATGTTTCTTGATGTGGTTAATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTGTTATTTTATAGTAATCAATTCTTCTAGAGTTCTTTTTCCGTTCTGTGTTTCACTAACGCGTAGTAAGCTTTGTTCCCTTTTTCCTGAGAGCCGAGGGTTTGTCGCAATGGGGGTGTTTGATAATATTGACTCAGCATTGAGGACACATGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTATGGACATTTCTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAATGAGTTTCTTTATTTAAAGAAGTCTTCATTTCACAAGAAGCTTTTCACTTTTAACAGAGCTGCTGGGTTTTACGTCATAAAATGAAAATATCGCGTCTAATATCGATGTTTTTCCCAAAGTTGTTTTTTCGGATATTACATTAAGTGTTTTAGTTGTTTGAGAGTTATGCTCAGAAACACTTGGAAATTTTAAGTGGATATCTTTTTATCATGTTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATG ++ +::6=A78??BEGH?@/$58;;;<97=6,*.9@@FC/7'+6:=+/*,&(',9C@9:877<@>=5+*$$&-:9:>@<>FFOH>DANFF>5/>9?@==86AD?3.:)367*&&&+;D411$-,0%)++%%3?GK?EE2.9;;D4B>>/0214:;B=*+*02+@;=A;;:3))$&)-/5?D@?:FD?=>>444+3.-)24-2673+-16C?=)-06>62=893>B?BC>D>AB?E6:C?DEEABC<>=5/)902/6+>BCGA;57*/05C4<@D<975@:*>C/06667/48(3)59661/12524>5<8>=:@:B@B<'((/2B:07=<7.>?@>D>68=E>-$(0665/):EEC48***87>AJG@*%2-:9'(9>:CE,%/15=68LKFCGD><:=?1-24417458=;?HCPH:89;=QF=BC<=B2:6BD22)-@;EE6?6;==>>8)$(.ADFC@7666588DDD?D=@29+*$&)08735452%%526453696871=(?89/0$8CA<26%'+**1;89:;;-2+++/27>@A<9/<>2,,/--C>0))%%=<6))1;3IG>ABCJB::=7;@3,,1(49@9<977877.....7@91-11;=--?(34;<--42+-<528EFFD?IHA>BBADF5%-,*/03=A<>>=(%%.0%((*;;DEGD@C?H<9=*3?A<7+=A>F:/04:///@A79664-,,&&333=<:?ABFH;77//==IINH29;<>A2>6<:@?F>A-::A>A>FCCCP;1@AD=EA<010*./23238(:)(4976''''%%489BEB@;:4B?>??A<>FEHGDD>D@<>LKF@A-;<<1;55=5<8=BG?CBEFAEG=DCA;;;=96C>?9<>66 +@a3804e93-6f81-4c49-8217-c80ef00ec343 +GGTATGCTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGGTCTCGTTTGTGCGTGGGCTCCTTCGTGTTGTACAAGAACAGCGGGTCTTGCATGTACAGATGTATCTTTTCTTTTTTTTTCATCTAATTCGTTTATCGCACATATTACATCATGGCTATTGTGTTGTTGTAAATATTTGATTATTATTGGTTTTGCTGCTTCTATCAAAGCGTTGATCCTTATCTTGCTTTGATTACTGAGTAATGAATTCATTTTTCATCTACATCAATGAGAATAATTGAGTCTTTTGAGACTAAGATTGAGCTAATGAAAGACAACGCTCTGCTTACTCTTCACCAAGCATTGATATTTCATTTCAAATTCATAGTCCCTATATCTAAAATCTCTTTGTTTTTGATCTGTTTGCTATTATTTCAATATCGTTAATTCTATTCCAATAAATTCTTTTCCCAGGTTTGCCTATTATTTCATCTTTTCTTTTGTGTTGAAGTAGTTTTGATGCGTTTTTATCGTTGCTTCTTTTTGTTTATGTTTCTTGATGTGGTTATTATCGCTGCGGTTTTGAATTCATATAGCTTACCTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTATTGTTATTTTTATAGTAATCAATTAACTTTCTGGAGGTTCTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTAAAACATTCCTTTTCCCTGAGAGCCGAGGGTTTGTCACGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGAGGACACGCTTGATTCACTTTGTGTGTTATCTATCGTTGAGTATTTTTGTGTTACTTCTGACCTTTCATCTCTTATTGTTATGGACATTTCTTTGGATGTGTCCATGTTATAAAAATAGCTATCCCAAAATGAGTTTTCTTTATTTAAAAGATGCTTCATTTCTAAAGCTTTTACTTTTAACAGAGCTGCTGGGTTTTTACGTCATAAAATGAAAATATCGTCTAATATCGATGTTTTTAAAGTTGTTTTTCGGATATTACATTAAGTGTTTTAGTTGTTTGAGTTATGCTCTCGAAACATAAAATTTTTAAGTGGATATCTTTTATCGTATTTAAACTTGCTCTCCATTTCTGTTTACGTTTACATAGTAATAATGTGTTTATTTATGCATCACTATGCCACTGTTTCTTTTCTAGAAGTATAATCAAAGTAATATTACTTTATAGTCTGTTTGGATTGATTTTAACCAGTTTGTCGGAGTTTCTTCTTGTGATTATTATTGTTCTGGTCGTAATCTCCTAAACTGAAAACGAAAAGCCACCTGGGGAGGTGGTTTGATCGAAGAAGGATTAGAATCAGTTAAAGAACTGCTTAACCAGGTAACTGTCTTGTGCAGGCAGTCACCAAAACTGTCCTTTCAGTGTAGCTGTAGTCAGGCCATCACTTCAGAATTACTCTCTTGAACCTCTCGCACATCGACTTTTACCAATGGCTGCTGCCGGTGGCGCTTTGTCGTCATCTTACAATTGGACTCCAGACGATAGTTACCGGATAAGGCGCAATCGGAGCTGAACAGGGGGTTCGTGCACACAGCCCAGCTTAGAACAGTTTTATTATTGCACCTTATTTGCCGTAACGCAGCTACGCAGACCGAGATACCTACAGCGTGAGCTGTGAAAGCGCCACGCTTCCGGGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCTGGGAGTCCGGAACAGAGCGCCTGGGGAACTGGAAACACCTGGTATCTTTACTCAGTCTATCGGGTTTCGCCACCTGTGGCTTGAGCGTCGATTTACTGTGATGCTCGTCAGGGCGGAGCCTGTGGAAAAACGCCTGCGGCGCTGGCTTCCTCCGGTGCTTTGCTTTTGCTCATGTTCTTTCCGACTTTATCCCCCGATTCTGTGGATAACCGTATTACCGCTTTTGGTGAGCTGACACCGCTCGCCGCAGTCGAACGACCGAGCGTAGCGAGTCAGTGAAACCAGGAAGCGGAAGAGCGCCTTATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCTGTCCTGAGCGTTATCTCTCTATGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGAGTTCGTGCAGCTTCTCACACATAGCAGCCTGTTCGTCAGCATCGGGTGCGTCCAGTTTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGGTACGGCTTGCTGCTGCTTGTTCATCTTTTCGTTTCTCCGTTCTGTCTGTCATCTGCGTTGATTATACATCATGATACCGCTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGGCATTTCTGTCCAGACAACACTGTCACTGCAAAAAGAGAACTGCCGTGCAGCTGTCAGTAATTCAGGCTTGCTGACAGGACAGGATGTGCAATTGTTACCGCGCATACATACGCTATTACAATTGCCCTGGTCAAGGGCTTTGCCCCGACACCCATGTCAGATACACAGACCATATTTTGCCGATAAACAGTGAAGATAATACGCTACCAGGCGTTTATCAAATCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAAGAAAAAAGGGCTGCTGCTAGTGCAGCAAGACCGTTTCACCGGTTATTTGGGCGGCAGCTCTCGGTAAGAAAGTTGCTCACTGACTGATGATCGGGTACTGAAAGAAAGTTATGAGACTGGGGCGTTAGAAAAAACTCTTTATCGACAGCAAGCGGCGTGTCGGGGACAGAGTATACGGGATTGCTGAGTCGCTATTACGGAGTATCACCGTGCCCTGTTATCAGACTTATGGCAGATTCATATAGCTTGGAGAGGGAAAACTGTCAAGCAGACAATTTATGTTTACCATAGCTCCCAAAGTGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCTGACGCATCCTTCCCTGTTTTCCCGGGGTAAAACATCTCTTTTTTACGGTGTCTGCGTCAGAATCGCGTTCAGCGCGTTTCAGCGGTTGCGTACAATTACAGCATTATGTTAAATTTTATAATTGTCTTTTAGTCATTGCGCTATGATTTTGTAGGTGGAGTTGTTTCATATTTTTGATATAAATTCTTTTTATCTCACTGAAGCAGTCATCGTCAGTATCAATGGTTTTGTTCTTCATTGATATGCCTATTCTAGAATCTGATTCCTTATTACAACTAAGGTAAACTTGAACTTTGCTTTCTTTTCATTATTTGGGTAAGCGTAATCAGGATCTAAGGATATGTAATAATAGATTCTTGTTCTTTTATTTTATTGAATAGATCGTCTACCTATATCTAAACACCTCTTTCTTACACGCGTGAGCAATAAGTTAGATCTTCTATTGCTTTTCATTACTTGTTTTTCCTGGCACTTGATAAGAAAGATATTTTGTGCTTCCGTTAATGGCTATTTCATTATGCGAGCTTGTTGGTGATGAAATGTTAAGCTCATTTAATGTTGAAATTATCGATCTTTCCGTGTCAGAAAACGTTCAATCAGCATCGATGATTAAGAATATACTCTTTTCATTTAAAAGACTCTATGCTTTCTAATCTCTAAGGGTTTGTTTAGTTTTGTCTTTCCATTTATTTTCAACATAAACATCATTAATTCCTTCTATTTCAAGTAGATTGCAAAGGAAGTGAAAATCATCATCACCCTCAACGAAAATGACTTTTTATAATCATTTATTTTCTCAGTTTCATTTATCTCACCTCCCAGCCATTTTCAACTGAAAAAGAAAAATCATCCATGTTGATTGCATTGCTGTAGGTTTTGAGATTCCTTGTCTCTTCCCAGTCTATGTCTGTCTCTTATACACATCTCCAGGCCACGAGACCAGAG ++ 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++ 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