Mercurial > repos > iuc > meme_dreme
diff test-data/meme_output_test1.html @ 1:cb8a2242bf03 draft
planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/meme commit e2cf796f991cbe8c96e0cc5a0056b7255ac3ad6b
| author | iuc |
|---|---|
| date | Thu, 17 May 2018 14:11:27 -0400 |
| parents | |
| children | 3e5c80594237 |
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/meme_output_test1.html Thu May 17 14:11:27 2018 -0400 @@ -0,0 +1,8005 @@ +<!DOCTYPE HTML> +<html> + <head> + <meta charset="UTF-8"> + <title>MEME</title> + <script> + // @JSON_VAR data + var data = { + "program": "MEME", + "version": "4.12.0", + "release": "Tue Jun 27 16:22:50 2017 -0700", + "stop_reason": "Stopped because requested number of motifs (1) found.", + "cmd": [ + "meme", "meme_input_1.fasta", "-o", "meme_test1_out", "-nostatus", + "-maxsize", "1000000" + ], + "options": { + "mod": "zoops", + "revcomp": false, + "nmotifs": 1, + "minw": 8, + "maxw": 50, + "minsites": 2, + "maxsites": 30, + "wnsites": 0.8, + "spmap": "pam", + "spfuzz": 120, + "maxwords": -1, + "prior": "megap", + "b": 7500, + "maxiter": 50, + "distance": 1e-05, + "wg": 11, + "ws": 1, + "noendgaps": false, + "substring": true + }, + "alphabet": { + "name": "Protein", + "like": "protein", + "ncore": 20, + "symbols": [ + { + "symbol": "A", + "name": 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"pvalue": 1.59e-05 + } + ] + }, { + "pvalue": 1.61e-03, + "sites": [ + { + "motif": 0, + "pos": 30, + "rc": false, + "pvalue": 4.02e-05 + } + ] + } + ] + }; + </script> + <script> +var site_url = "http://meme-suite.org"; +</script> + <script> + +/* + * $ + * + * Shorthand function for getElementById + */ +function $(el) { + return document.getElementById(el); +} + + +/* + * See http://stackoverflow.com/a/5450113/66387 + * Does string multiplication like the perl x operator. + */ +function string_mult(pattern, count) { + if (count < 1) return ''; + var result = ''; + while (count > 1) { + if (count & 1) result += pattern; + count >>= 1, pattern += pattern; + } + return result + pattern; +} + +/* + * See http://stackoverflow.com/questions/814613/how-to-read-get-data-from-a-url-using-javascript + * Slightly modified with information from + * https://developer.mozilla.org/en/DOM/window.location + */ +function parse_params() { + "use strict"; + var search, queryStart, queryEnd, query, params, nvPairs, i, nv, n, v; + search = window.location.search; + queryStart = search.indexOf("?") + 1; + queryEnd = search.indexOf("#") + 1 || search.length + 1; + query = search.slice(queryStart, queryEnd - 1); + + if (query === search || query === "") return {}; + + params = {}; + nvPairs = query.replace(/\+/g, " ").split("&"); + + for (i = 0; i < nvPairs.length; i++) { + nv = nvPairs[i].split("="); + n = decodeURIComponent(nv[0]); + v = decodeURIComponent(nv[1]); + // allow a name to be used multiple times + // storing each value in the array + if (!(n in params)) { + params[n] = []; + } + params[n].push(nv.length === 2 ? v : null); + } + return params; +} + +/* + * coords + * + * Calculates the x and y offset of an element. + * From http://www.quirksmode.org/js/findpos.html + * with alterations to take into account scrolling regions + */ +function coords(elem) { + var myX = myY = 0; + if (elem.getBoundingClientRect) { + var rect; + rect = elem.getBoundingClientRect(); + myX = rect.left + ((typeof window.pageXOffset !== "undefined") ? + window.pageXOffset : document.body.scrollLeft); + myY = rect.top + ((typeof window.pageYOffset !== "undefined") ? + window.pageYOffset : document.body.scrollTop); + } else { + // this fall back doesn't properly handle absolutely positioned elements + // inside a scrollable box + var node; + if (elem.offsetParent) { + // subtract all scrolling + node = elem; + do { + myX -= node.scrollLeft ? node.scrollLeft : 0; + myY -= node.scrollTop ? node.scrollTop : 0; + } while (node = node.parentNode); + // this will include the page scrolling (which is unwanted) so add it back on + myX += (typeof window.pageXOffset !== "undefined") ? window.pageXOffset : document.body.scrollLeft; + myY += (typeof window.pageYOffset !== "undefined") ? window.pageYOffset : document.body.scrollTop; + // sum up offsets + node = elem; + do { + myX += node.offsetLeft; + myY += node.offsetTop; + } while (node = node.offsetParent); + } + } + return [myX, myY]; +} + +/* + * position_popup + * + * Positions a popup relative to an anchor element. + * + * The avaliable positions are: + * 0 - Centered below the anchor. + */ +function position_popup(anchor, popup, position) { + "use strict"; + var a_x, a_y, a_w, a_h, p_x, p_y, p_w, p_h; + var a_xy, spacer, margin, scrollbar, page_w; + // define constants + spacer = 5; + margin = 15; + scrollbar = 15; + // define the positions and widths + a_xy = coords(anchor); + a_x = a_xy[0]; + a_y = a_xy[1]; + a_w = anchor.offsetWidth; + a_h = anchor.offsetHeight; + p_w = popup.offsetWidth; + p_h = popup.offsetHeight; + page_w = null; + if (window.innerWidth) { + page_w = window.innerWidth; + } else if (document.body) { + page_w = document.body.clientWidth; + } + // check the position type is defined + if (typeof position !== "number") { + position = 0; + } + // calculate the popup position + switch (position) { + case 1: + p_x = a_x + a_w + spacer; + p_y = a_y + (a_h / 2) - (p_h / 2); + break; + case 0: + default: + p_x = a_x + (a_w / 2) - (p_w / 2); + p_y = a_y + a_h + spacer; + break; + } + // constrain the popup position + if (p_x < margin) { + p_x = margin; + } else if (page_w != null && (p_x + p_w) > (page_w - margin - scrollbar)) { + p_x = page_w - margin - scrollbar - p_w; + } + if (p_y < margin) { + p_y = margin; + } + // position the popup + popup.style.left = p_x + "px"; + popup.style.top = p_y + "px"; +} + +function lookup_help_popup(popup_id) { + var _body, pop, info; + pop = document.getElementById(popup_id); + if (pop == null) { + _body = document.getElementsByTagName("body")[0]; + pop = document.createElement("div"); + pop.className = "pop_content"; + pop.id = popup_id; + pop.style.backgroundColor = "#FFC"; + pop.style.borderColor = "black"; + info = document.createElement("p"); + info.style.fontWeight = "bold"; + info.appendChild(document.createTextNode("Error: No popup for topic \"" + popup_id + "\".")); + pop.appendChild(info); + // this might cause problems with the menu, but as this only happens + // when something is already wrong I don't think that's too much of a problem + _body.insertBefore(pop, _body.firstChild); + } + if (document.getElementsByTagName('body')[0].hasAttribute("data-autobtns")) { + if (!/\bauto_buttons\b/.test(pop.className)) { + pop.className += " auto_buttons"; + var back_btn_sec = document.createElement("div"); + back_btn_sec.className = "nested_only pop_back_sec"; + var back_btn = document.createElement("span"); + back_btn.className = "pop_back"; + back_btn.appendChild(document.createTextNode("<< back")); + back_btn.addEventListener("click", function(e) { + help_return(); + }, false); + back_btn_sec.appendChild(back_btn); + pop.insertBefore(back_btn_sec, pop.firstChild); + var close_btn_sec = document.createElement("div"); + close_btn_sec.className = "pop_close_sec"; + var close_btn = document.createElement("span"); + close_btn.className = "pop_close"; + close_btn.appendChild(document.createTextNode("close")); + close_btn.addEventListener("click", function(e) { + help_popup(); + }, false); + close_btn_sec.appendChild(close_btn); + pop.appendChild(close_btn_sec); + } + } + return pop; +} + +/* + * help_popup + * + * Moves around help pop-ups so they appear + * below an activator. + */ +function help_popup(activator, popup_id) { + "use strict"; + var pop; + // set default values + if (typeof help_popup.popup === "undefined") { + help_popup.popup = []; + } + if (typeof help_popup.activator === "undefined") { + help_popup.activator = null; + } + var last_pop = (help_popup.popup.length > 0 ? help_popup.popup[help_popup.popup.length - 1] : null); + if (typeof(activator) == "undefined") { // no activator so hide + if (last_pop != null) { + last_pop.style.display = 'none'; + help_popup.popup = []; + } + return; + } + pop = lookup_help_popup(popup_id); + if (pop == last_pop) { + if (activator == help_popup.activator) { + //hide popup (as we've already shown it for the current help button) + last_pop.style.display = 'none'; + help_popup.popup = []; + return; // toggling complete! + } + } else if (last_pop != null) { + //activating different popup so hide current one + last_pop.style.display = 'none'; + } + help_popup.popup = [pop]; + help_popup.activator = activator; + toggle_class(pop, "nested", false); + //must make the popup visible to measure it or it has zero width + pop.style.display = 'block'; + position_popup(activator, pop); +} + +/* + * help_refine + * + * Intended for links within a help popup. Stores a stack of state so + * you can go back. + */ +function help_refine(popup_id) { + if (help_popup.popup == null || help_popup.popup.length == 0 || help_popup.activator == null) { + throw new Error("Can not refine a help popup when one is not shown!"); + } + var pop = lookup_help_popup(popup_id); + var last_pop = help_popup.popup[help_popup.popup.length - 1]; + if (pop == last_pop) return; // slightly odd, but no real cause for alarm + help_popup.popup.push(pop); + toggle_class(pop, "nested", true); + last_pop.style.display = "none"; + //must make the popup visible to measure it or it has zero width + pop.style.display = "block"; + position_popup(help_popup.activator, pop); +} + +/* + * help_return + * + * Intended for links within a help popup. Stores a stack of state so + * you can go back. + */ +function help_return() { + if (help_popup.popup == null || help_popup.popup.length == 0 || help_popup.activator == null) { + throw new Error("Can not return to a earlier help popup when one is not shown!"); + } + var last_pop = help_popup.popup.pop(); + last_pop.style.display = "none"; + var pop = (help_popup.popup.length > 0 ? help_popup.popup[help_popup.popup.length - 1] : null); + if (pop != null) { + toggle_class(pop, "nested", help_popup.popup.length > 1); + pop.style.display = "block"; + position_popup(help_popup.activator, pop); + } else { + help_popup.activator = null; + } +} + +/* + * update_scroll_pad + * + * Creates padding at the bottom of the page to allow + * scrolling of anything into view. + */ +function update_scroll_pad() { + var page, pad; + page = (document.compatMode === "CSS1Compat") ? document.documentElement : document.body; + pad = $("scrollpad"); + if (pad === null) { + pad = document.createElement("div"); + pad.id = 'scrollpad'; + document.getElementsByTagName('body')[0].appendChild(pad); + } + pad.style.height = Math.abs(page.clientHeight - 100) + "px"; +} + +function substitute_classes(node, remove, add) { + "use strict"; + var list, all, i, cls, classes; + list = node.className.split(/\s+/); + all = {}; + for (i = 0; i < list.length; i++) { + if (list[i].length > 0) all[list[i]] = true; + } + for (i = 0; i < remove.length; i++) { + if (all.hasOwnProperty(remove[i])) { + delete all[remove[i]]; + } + } + for (i = 0; i < add.length; i++) { + all[add[i]] = true; + } + classes = ""; + for (cls in all) { + classes += cls + " "; + } + node.className = classes; +} + +/* + * toggle_class + * + * Adds or removes a class from the node. If the parameter 'enabled' is not + * passed then the existence of the class will be toggled, otherwise it will be + * included if enabled is true. + */ +function toggle_class(node, cls, enabled) { + var classes = node.className; + var list = classes.replace(/^\s+/, '').replace(/\s+$/, '').split(/\s+/); + var found = false; + for (var i = 0; i < list.length; i++) { + if (list[i] == cls) { + list.splice(i, 1); + i--; + found = true; + } + } + if (typeof enabled == "undefined") { + if (!found) list.push(cls); + } else { + if (enabled) list.push(cls); + } + node.className = list.join(" "); +} + +/* + * find_child + * + * Searches child nodes in depth first order and returns the first it finds + * with the className specified. + * TODO replace with querySelector + */ +function find_child(node, className) { + var pattern; + if (node == null || typeof node !== "object") { + return null; + } + if (typeof className === "string") { + pattern = new RegExp("\\b" + className + "\\b"); + } else { + pattern = className; + } + if (node.nodeType == Node.ELEMENT_NODE && + pattern.test(node.className)) { + return node; + } else { + var result = null; + for (var i = 0; i < node.childNodes.length; i++) { + result = find_child(node.childNodes[i], pattern); + if (result != null) break; + } + return result; + } +} + +/* + * find_parent + * + * Searches parent nodes outwards from the node and returns the first it finds + * with the className specified. + */ +function find_parent(node, className) { + var pattern; + pattern = new RegExp("\\b" + className + "\\b"); + do { + if (node.nodeType == Node.ELEMENT_NODE && + pattern.test(node.className)) { + return node; + } + } while (node = node.parentNode); + return null; +} + +/* + * find_parent_tag + * + * Searches parent nodes outwards from the node and returns the first it finds + * with the tag name specified. HTML tags should be specified in upper case. + */ +function find_parent_tag(node, tag_name) { + do { + if (node.nodeType == Node.ELEMENT_NODE && node.tagName == tag_name) { + return node; + } + } while (node = node.parentNode); + return null; +} + +/* + * __toggle_help + * + * Uses the 'topic' property of the this object to + * toggle display of a help topic. + * + * This function is not intended to be called directly. + */ +function __toggle_help(e) { + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + + help_popup(this, this.getAttribute("data-topic")); +} + +function setup_help_button(button) { + "use strict"; + var topic; + if (button.hasAttribute("data-topic")) { + topic = button.getAttribute("data-topic"); + if (document.getElementById(topic) != null) { + button.tabIndex = "0"; // make keyboard selectable + button.addEventListener("click", function() { + help_popup(button, topic); + }, false); + button.addEventListener("keydown", function(e) { + // toggle only on Enter or Spacebar, let other keys do their thing + if (e.keyCode !== 13 && e.keyCode !== 32) return; + // stop a submit or something like that + e.preventDefault(); + help_popup(button, topic); + }, false); + } else { + button.style.visibility = "hidden"; + } + } + button.className += " active"; +} + +/* + * help_button + * + * Makes a help button for the passed topic. + */ +function help_button(topic) { + var btn = document.createElement("div"); + btn.className = "help"; + btn.setAttribute("data-topic", topic); + setup_help_button(btn); + return btn; +} + +/* + * prepare_download + * + * Sets the attributes of a link to setup a file download using the given content. + * If no link is provided then create one and click it. + */ +function prepare_download(content, mimetype, filename, link) { + "use strict"; + // if no link is provided then create one and click it + var click_link = false; + if (!link) { + link = document.createElement("a"); + click_link = true; + } + try { + // Use a BLOB to convert the text into a data URL. + // We could do this manually with a base 64 conversion. + // This will only be supported on modern browsers, + // hence the try block. + var blob = new Blob([content], {type: mimetype}); + var reader = new FileReader(); + reader.onloadend = function() { + // If we're lucky the browser will also support the download + // attribute which will let us suggest a file name to save the link. + // Otherwise it is likely that the filename will be unintelligible. + link.setAttribute("download", filename); + link.href = reader.result; + if (click_link) { + // must add the link to click it + document.body.appendChild(link); + link.click(); + document.body.removeChild(link); + } + } + reader.readAsDataURL(blob); + } catch (error) { + if (console && console.log) console.log(error); + // probably an old browser + link.href = ""; + link.visible = false; + } +} + +/* + * add_cell + * + * Add a cell to the table row. + */ +function add_cell(row, node, cls, click_action) { + var cell = row.insertCell(row.cells.length); + if (node) cell.appendChild(node); + if (cls && cls !== "") cell.className = cls; + if (click_action) cell.addEventListener("click", click_action, false); +} + +/* + * add_header_cell + * + * Add a header cell to the table row. + */ +function add_header_cell(row, node, help_topic, cls, colspan) { + var th = document.createElement("th"); + if (node) th.appendChild(node); + if (help_topic && help_topic !== "") th.appendChild(help_button(help_topic)); + if (cls && cls !== "") th.className = cls; + if (typeof colspan == "number" && colspan > 1) th.colSpan = colspan; + row.appendChild(th); +} + +/* + * add_text_cell + * + * Add a text cell to the table row. + */ +function add_text_cell(row, text, cls, action) { + var node = null; + if (typeof(text) != 'undefined') node = document.createTextNode(text); + add_cell(row, node, cls, action); +} + +/* + * add_text_header_cell + * + * Add a text header cell to the table row. + */ +function add_text_header_cell(row, text, help_topic, cls, action, colspan) { + var node = null; + if (typeof(text) != 'undefined') { + var nbsp = (help_topic ? "\u00A0" : ""); + var str = "" + text; + var parts = str.split(/\n/); + if (parts.length === 1) { + if (action) { + node = document.createElement("span"); + node.appendChild(document.createTextNode(str + nbsp)); + } else { + node = document.createTextNode(str + nbsp); + } + } else { + node = document.createElement("span"); + for (var i = 0; i < parts.length; i++) { + if (i !== 0) { + node.appendChild(document.createElement("br")); + } + node.appendChild(document.createTextNode(parts[i])); + } + } + if (action) { + node.addEventListener("click", action, false); + node.style.cursor = "pointer"; + } + } + add_header_cell(row, node, help_topic, cls, colspan); +} + +function setup_help() { + "use strict"; + var help_buttons, i; + help_buttons = document.querySelectorAll(".help:not(.active)"); + for (i = 0; i < help_buttons.length; i++) { + setup_help_button(help_buttons[i]); + } +} + +function setup_scrollpad() { + "use strict"; + if (document.getElementsByTagName('body')[0].hasAttribute("data-scrollpad") && document.getElementById("scrollpad") == null) { + window.addEventListener("resize", update_scroll_pad, false); + update_scroll_pad(); + } +} + +// anon function to avoid polluting global scope +(function() { + "use strict"; + window.addEventListener("load", function load(evt) { + window.removeEventListener("load", load, false); + setup_help(); + setup_scrollpad(); + }, false); +})(); + +/* + * make_link + * + * Creates a text node and if a URL is specified it surrounds it with a link. + * If the URL doesn't begin with "http://" it automatically adds it, as + * relative links don't make much sense in this context. + */ +function make_link(text, url) { + var textNode = null; + var link = null; + if (typeof text !== "undefined" && text !== null) textNode = document.createTextNode(text); + if (typeof url === "string") { + if (url.indexOf("//") == -1) { + url = "http://" + url; + } + link = document.createElement('a'); + link.href = url; + if (textNode) link.appendChild(textNode); + return link; + } + return textNode; +} +</script> + <script> + // + // return true if any part of the passed element is visible in the viewport + // + function element_in_viewport(elem) { + var rect; + try { + rect = elem.getBoundingClientRect(); + } catch (e) { + return false; + } + return ( + rect.top < (window.innerHeight || document.body.clientHeight) && + rect.bottom > 0 && + rect.left < (window.innerWidth || document.body.clientWidth) && + rect.right > 0 + ); + } + + // + // Functions to delay a drawing task until it is required or it would not lag the display to do so + // + + // a list of items still to be drawn + var drawable_list = []; + // the delay between drawing objects that are not currently visible + var draw_delay = 1; + // the delay after a user interaction + var user_delay = 300; + // the delay after a user has stopped scrolling and is viewing the stuff drawn on the current page + var stop_delay = 300; + // the timer handle; allows resetting of the timer after user interactions + var draw_timer = null; + + // + // Drawable + // + // elem - a page element which defines the position on the page that drawing is to be done + // task - an object with the method run which takes care of painting the object + // + var Drawable = function(elem, task) { + this.elem = elem; + this.task = task; + } + + // + // Drawable.is_visible + // + // Determines if the element is visible in the viewport + // + Drawable.prototype.is_visible = function() { + return element_in_viewport(this.elem); + } + + // + // Drawable.run + // + // Run the task held by the drawable + Drawable.prototype.run = function() { + if (this.task) this.task.run(); + this.task = null; + } + + // + // Drawable.run + // + // Run the task iff visible + // returns true if the task ran or has already run + Drawable.prototype.run_visible = function() { + if (this.task) { + if (element_in_viewport(this.elem)) { + this.task.run(); + this.task = null; + return true; + } + return false; + } else { + return true; + } + } + + // + // draw_on_screen + // + // Checks each drawable object and draws those on screen. + // + function draw_on_screen() { + var found = false; + for (var i = 0; i < drawable_list.length; i++) { + if (drawable_list[i].run_visible()) { + drawable_list.splice(i--, 1); + found = true; + } + } + return found; + } + + // + // process_draw_tasks + // + // Called on a delay to process the next avaliable + // draw task. + // + function process_draw_tasks() { + var delay = draw_delay; + draw_timer = null; + if (drawable_list.length == 0) return; //no more tasks + if (draw_on_screen()) { + delay = stop_delay; //give the user a chance to scroll + } else { + //get next task + var drawable = drawable_list.shift(); + drawable.task.run(); + } + //allow UI updates between tasks + draw_timer = window.setTimeout("process_draw_tasks()", delay); + } + + // + // delayed_process_draw_tasks + // + // Call process_draw_tasks after a short delay. + // The delay serves to group multiple redundant events. + // Should be set as event handler for onscroll and onresize. + // + function delayed_process_draw_tasks() { + //reset the timer + if (drawable_list.length > 0) { + if (draw_timer != null) clearTimeout(draw_timer); + draw_timer = window.setTimeout("process_draw_tasks()", user_delay); + } + } + + // + // add_draw_task + // + // Add a drawing task to be called immediately if it is + // visible, or to be called on a delay to reduce stuttering + // effect on the web browser. + function add_draw_task(elem, task) { + drawable = new Drawable(elem, task); + if (drawable.is_visible()) { + task.run(); + } else { + drawable_list.push(drawable); + //reset timer + if (draw_timer != null) clearTimeout(draw_timer); + draw_timer = window.setTimeout("process_draw_tasks()", user_delay); + } + } + +</script> + <script> +//====================================================================== +// start Alphabet object +//====================================================================== +var Alphabet = function(alphabet, background) { + "use strict"; + var i, j, sym, aliases, complement, comp_e_sym, ambigs, generate_background; + generate_background = (background == null); + if (generate_background) { + background = []; + for (i = 0; i < alphabet.ncore; i++) background[i] = 1.0 / alphabet.ncore; + } else if (alphabet.ncore != background.length) { + throw new Error("The background length does not match the alphabet length."); + } + this.name = alphabet.name; + this.like = (alphabet.like != null ? alphabet.like.toUpperCase() : null); + this.ncore = alphabet.ncore; + this.symbols = alphabet.symbols; + this.background = background; + this.genbg = generate_background; + this.encode = {}; + this.encode2core = {}; + this.complement = {}; + // check if all symbols are same case + var seen_uc = false; + var seen_lc = false; + var check_case = function (syms) { + var s, sym; + if (typeof syms === "string") { + for (s = 0; s < syms.length; s++) { + sym = syms.charAt(s); + if (sym >= 'a' && sym <= 'z') seen_lc = true; + else if (sym >= 'A' && sym <= 'Z') seen_uc = true; + } + } + }; + for (i = 0; i < this.symbols.length; i++) { + check_case(this.symbols[i].symbol); + check_case(this.symbols[i].aliases); + } + // now map symbols to indexes + var update_array = function(array, syms, index) { + var s, sym; + if (typeof syms === "string") { + for (s = 0; s < syms.length; s++) { + sym = syms.charAt(s); + array[sym] = index; + // when only a single case is used, then encode as case insensitive + if (seen_uc != seen_lc) { + if (sym >= 'a' && sym <= 'z') { + array[sym.toUpperCase()] = index; + } else if (sym >= 'A' && sym <= 'Z') { + array[sym.toLowerCase()] = index; + } + } + } + } + } + // map core symbols to index + for (i = 0; i < this.ncore; i++) { + update_array(this.encode2core, this.symbols[i].symbol, i); + update_array(this.encode, this.symbols[i].symbol, i); + update_array(this.encode2core, this.symbols[i].aliases, i); + update_array(this.encode, this.symbols[i].aliases, i); + } + // map ambigous symbols to index + ambigs = {}; + for (i = this.ncore; i < this.symbols.length; i++) { + update_array(this.encode, this.symbols[i].symbol, i); + update_array(this.encode, this.symbols[i].aliases, i); + ambigs[this.symbols[i].equals] = i; + } + // determine complements + for (i = 0; i < this.ncore; i++) { + complement = this.symbols[i].complement; + if (typeof complement === "string") { + this.complement[i] = this.encode2core[complement]; + } + } + next_symbol: + for (i = this.ncore; i < this.symbols.length; i++) { + complement = ""; + for (j = 0; j < this.symbols[i].equals.length; j++) { + comp_e_sym = this.complement[this.encode2core[this.symbols[i].equals.charAt(j)]]; + if (typeof comp_e_sym !== "number") continue next_symbol; + complement += this.symbols[comp_e_sym].symbol; + } + complement = complement.split("").sort().join(""); + if (typeof ambigs[complement] === "number") { + this.complement[i] = ambigs[complement]; + } + } + // determine case insensitivity + this.case_insensitive = true; + if (seen_uc == seen_lc) { + // when there is a mixture of cases it probably won't + // be case insensitive but we still need to check + loop: + for (i = 0; i < this.symbols.length; i++) { + sym = this.symbols[i].symbol; + if (sym >= 'A' && sym <= 'Z') { + if (this.encode[sym.toLowerCase()] != i) { + this.case_insensitive = false; + break loop; + } + } else if (sym >= 'a' && sym <= 'z') { + if (this.encode[sym.toUpperCase()] != i) { + this.case_insensitive = false; + break loop; + } + } + aliases = this.symbols[i].aliases; + if (aliases != null) { + for (j = 0; j < aliases.length; j++) { + sym = aliases.charAt(j); + if (sym >= 'A' && sym <= 'Z') { + if (this.encode[sym.toLowerCase()] != i) { + this.case_insensitive = false; + break loop; + } + } else if (sym >= 'a' && sym <= 'z') { + if (this.encode[sym.toUpperCase()] != i) { + this.case_insensitive = false; + break loop; + } + } + } + } + } + } + // normalise aliases to remove the prime symbol and eliminate + // the alternate cases when the alphabet is case insensitive + var seen, out; + for (i = 0; i < this.symbols.length; i++) { + sym = this.symbols[i].symbol; + aliases = this.symbols[i].aliases; + if (typeof aliases != "string") aliases = ""; + seen = {}; + out = []; + if (this.case_insensitive) { + sym = sym.toUpperCase(); + aliases = aliases.toUpperCase(); + } + seen[sym] = true; + for (j = 0; j < aliases.length; j++) { + if (!seen[aliases.charAt(j)]) { + seen[aliases.charAt(j)] = true; + out.push(aliases.charAt(j)); + } + } + this.symbols[i].aliases = out.sort().join(""); + } +}; +// return the name of the alphabet +Alphabet.prototype.get_alphabet_name = function() { + return this.name; +}; +// return if the alphabet can be complemented +Alphabet.prototype.has_complement = function() { + return (typeof this.symbols[0].complement === "string"); +}; +// return true if an uppercase letter has the same meaning as the lowercase form +Alphabet.prototype.is_case_insensitive = function() { + return this.case_insensitive; +}; +// return the information content of an alphabet letter +Alphabet.prototype.get_ic = function() { + return Math.log(this.ncore) / Math.LN2; +}; +// return the count of the core alphabet symbols +Alphabet.prototype.get_size_core = function() { + return this.ncore; +}; +// return the count of all alphabet symbols +Alphabet.prototype.get_size_full = function() { + return this.symbols.length; +}; +// return the symbol for the given alphabet index +Alphabet.prototype.get_symbol = function(alph_index) { + "use strict"; + if (alph_index < 0 || alph_index >= this.symbols.length) { + throw new Error("Alphabet index out of bounds"); + } + return this.symbols[alph_index].symbol; +}; +// return the aliases for the given alphabet index +Alphabet.prototype.get_aliases = function(alph_index) { + "use strict"; + if (alph_index < 0 || alph_index >= this.symbols.length) { + throw new Error("Alphabet index out of bounds"); + } + var sym_obj = this.symbols[alph_index]; + return (sym_obj.aliases != null ? sym_obj.aliases : ""); +}; +// return the name for the given alphabet index +Alphabet.prototype.get_name = function(alph_index) { + "use strict"; + var sym; + if (alph_index < 0 || alph_index >= this.symbols.length) { + throw new Error("Alphabet index out of bounds"); + } + sym = this.symbols[alph_index]; + return (typeof sym.name === "string" ? sym.name : sym.symbol); +}; +// return the alphabet it is like or null +Alphabet.prototype.get_like = function() { + "use strict"; + return this.like; +}; +// return the index of the complement for the given alphabet index +Alphabet.prototype.get_complement = function(alph_index) { + var comp_e_sym = this.complement[alph_index]; + if (typeof comp_e_sym === "number") { + return comp_e_sym; + } else { + return -1; + } +}; +// return a string containing the core symbols +Alphabet.prototype.get_symbols = function() { + "use strict"; + var i, core_symbols; + core_symbols = ""; + for (i = 0; i < this.ncore; i++) { + core_symbols += this.symbols[i].symbol; + } + return core_symbols; +}; +// return if the background was not a uniform generated background +Alphabet.prototype.has_bg = function() { + "use strict"; + return !this.genbg; +}; +// get the background frequency for the index +Alphabet.prototype.get_bg_freq = function(alph_index) { + "use strict"; + var freq, i, symbols; + if (alph_index >= 0) { + if (alph_index < this.ncore) { + return this.background[alph_index]; + } else if (alph_index < this.symbols.length) { + freq = 0; + symbols = this.symbols[alph_index].equals; + for (i = 0; i < symbols.length; i++) { + freq += this.background[this.encode2core[symbols.charAt(i)]]; + } + return freq; + } + } + throw new Error("The alphabet index is out of range."); +}; +// get the colour of the index +Alphabet.prototype.get_colour = function(alph_index) { + "use strict"; + if (alph_index < 0 || alph_index >= this.symbols.length) { + throw new Error("BAD_ALPHABET_INDEX"); + } + if (typeof this.symbols[alph_index].colour != "string") { + return "black"; + } + return "#" + this.symbols[alph_index].colour; +}; +// get the rgb componets of the colour at the index +Alphabet.prototype.get_rgb = function(alph_index) { + "use strict"; + if (alph_index < 0 || alph_index >= this.symbols.length) { + throw new Error("BAD_ALPHABET_INDEX"); + } + if (typeof this.symbols[alph_index].colour != "string") { + return {"red": 0, "green": 0, "blue": 0}; + } + var colour = this.symbols[alph_index].colour; + var red = parseInt(colour.substr(0, 2), 16) / 255; + var green = parseInt(colour.substr(2, 2), 16) / 255; + var blue = parseInt(colour.substr(4, 2), 16) / 255; + return {"red": red, "green": green, "blue": blue}; +}; +// convert a symbol into the index +Alphabet.prototype.get_index = function(letter) { + "use strict"; + var alph_index; + alph_index = this.encode[letter]; + if (typeof alph_index === "undefined") { + return -1; + } + return alph_index; +}; +// convert a symbol into the list of core indexes that it equals +Alphabet.prototype.get_indexes = function(letter) { + "use strict"; + var alph_index, comprise_str, i, comprise_list; + alph_index = this.encode[letter]; + if (typeof alph_index === "undefined") { + throw new Error("Unknown letter"); + } + comprise_str = this.symbols[alph_index].equals; + comprise_list = []; + if (typeof comprise_str == "string") { + for (i = 0; i < comprise_str.length; i++) { + comprise_list.push(this.encode2core[comprise_str.charAt(i)]); + } + } else { + comprise_list.push(alph_index); + } + return comprise_list; +}; +// check if a symbol is the primary way of representing the symbol in the alphabet +Alphabet.prototype.is_prime_symbol = function(letter) { + var alph_index; + alph_index = this.encode[letter]; + if (alph_index == null) return false; + if (this.is_case_insensitive()) { + return (this.symbols[alph_index].symbol.toUpperCase() == letter.toUpperCase()); + } else { + return (this.symbols[alph_index].symbol == letter); + } +}; +// compare 2 alphabets +Alphabet.prototype.equals = function(other) { + "use strict"; + var i, sym1, sym2; + // first check that it's actually an alphabet object + if (!(typeof other === "object" && other != null && other instanceof Alphabet)) { + return false; + } + // second shortcircuit if it's the same object + if (this === other) return true; + // compare + if (this.name !== other.name) return false; + if (this.ncore !== other.ncore) return false; + if (this.symbols.length !== other.symbols.length) return false; + for (i = 0; i < this.symbols.length; i++) { + sym1 = this.symbols[i]; + sym2 = other.symbols[i]; + if (sym1.symbol !== sym2.symbol) return false; + if (sym1.aliases !== sym2.aliases) return false; + if (sym1.name !== sym2.name) return false; + if (typeof sym1.colour !== typeof sym2.colour || + (typeof sym1.colour === "string" && typeof sym2.colour === "string" && + parseInt(sym1.colour, 16) != parseInt(sym2.colour, 16))) { + return false; + } + if (sym1.complement !== sym2.complement) return false; + if (sym1.equals !== sym2.equals) return false; + } + return true; +}; +Alphabet.prototype.check_core_subset = function(super_alph) { + var complement_same = true; + var seen_set = {}; + var sub_i, sub_symbol, super_i, super_symbol; + for (sub_i = 0; sub_i < this.ncore; sub_i++) { + sub_symbol = this.symbols[sub_i]; + super_i = super_alph.encode[sub_symbol.symbol]; + if (super_i == null) return 0; + super_symbol = super_alph.symbols[super_i]; + if (seen_set[super_i]) return 0; + seen_set[super_i] = true; + // check complement + if (sub_symbol.complement != null && super_symbol.complement != null) { + if (super_alph.encode[sub_symbol.complement] != super_alph.encode[super_symbol.complement]) { + complement_same = false; + } + } else if (sub_symbol.complement != null || super_symbol.complement != null) { + complement_same = false; + } + } + return (complement_same ? 1 : -1); +}; +// convert a sequence to its reverse complement +Alphabet.prototype.invcomp_seq = function(seq) { + "use strict"; + var syms, i, e_sym, comp_e_sym; + if (!this.has_complement()) throw new Error("Alphabet must be complementable"); + syms = seq.split(""); + for (i = 0; i < syms.length; i++) { + e_sym = this.encode[syms[i]]; + if (typeof e_sym === "undefined") { + e_sym = this.ncore; // wildcard + } + comp_e_sym = this.complement[e_sym]; + if (typeof comp_e_sym === "undefined") { + comp_e_sym = e_sym; // not complementable + } + syms[i] = this.symbols[comp_e_sym].symbol; + } + return syms.reverse().join(""); +}; +// convert the alphabet to the text version +Alphabet.prototype.as_text = function() { + "use strict"; + function name_as_text(name) { + var i, c, out; + out = "\""; + for (i = 0; i < name.length; i++) { + c = name.charAt(i); + if (c == "\"") { + out += "\\\""; + } else if (c == "/") { + out += "\\/"; + } else if (c == "\\") { + out += "\\\\"; + } else { + out += c; + } + } + out += "\""; + return out; + } + function symbol_as_text(sym) { + var out; + out = sym.symbol; + if (typeof sym.name === "string" && sym.name != sym.symbol) { + out += " " + name_as_text(sym.name); + } + if (typeof sym.colour === "string") { + out += " " + sym.colour; + } + return out; + } + var out, i, j, c, sym; + out = ""; + // output core symbols with 2 way complements + for (i = 0; i < this.ncore; i++) { + c = this.complement[i]; + if (typeof c === "number" && i < c && this.complement[c] === i) { + out += symbol_as_text(this.symbols[i]) + " ~ " + symbol_as_text(this.symbols[c]) + "\n"; + } + } + // output core symbols with no complement + for (i = 0; i < this.ncore; i++) { + if (typeof this.complement[i] === "undefined") { + out += symbol_as_text(this.symbols[i]) + "\n"; + } + } + // output ambiguous symbols that have comprising characters + for (i = this.ncore; i < this.symbols.length; i++) { + if (this.symbols[i].equals.length == 0) break; + out += symbol_as_text(this.symbols[i]) + " = " + this.symbols[i].equals + "\n"; + if (typeof this.symbols[i].aliases === "string") { + for (j = 0; j < this.symbols[i].aliases.length; j++) { + if (this.symbols[i].aliases.charAt(j) == this.symbols[i].symbol) continue; + out += this.symbols[i].aliases.charAt(j) + " = " + this.symbols[i].equals + "\n"; + } + } + } + // output aliases of core symbols + for (i = 0; i < this.ncore; i++) { + if (typeof this.symbols[i].aliases === "string") { + for (j = 0; j < this.symbols[i].aliases.length; j++) { + if (this.symbols[i].aliases.charAt(j) == this.symbols[i].symbol) continue; + out += this.symbols[i].aliases.charAt(j) + " = " + this.symbols[i].symbol + "\n"; + } + } + } + // output gap symbols + i = this.symbols.length - 1; + if (this.symbols[i].equals.length == 0) { + out += symbol_as_text(this.symbols[i]) + " =\n"; + if (typeof this.symbols[i].aliases === "string") { + for (j = 0; j < this.symbols[i].aliases.length; j++) { + if (this.symbols[i].aliases.charAt(j) == this.symbols[i].symbol) continue; + out += this.symbols[i].aliases.charAt(j) + " =\n"; + } + } + } + return out; +}; +// output the alphabet as it appears in minimal MEME format +Alphabet.prototype.as_meme = function() { + "use strict"; + function name_as_text(name) { + var i, c, out; + out = "\""; + for (i = 0; i < name.length; i++) { + c = name.charAt(i); + if (c == "\"") { + out += "\\\""; + } else if (c == "/") { + out += "\\/"; + } else if (c == "\\") { + out += "\\\\"; + } else { + out += c; + } + } + out += "\""; + return out; + } + if (this.equals(AlphStd.DNA)) { + return "ALPHABET= ACGT\n"; + } else if (this.equals(AlphStd.PROTEIN)) { + return "ALPHABET= ACDEFGHIKLMNPQRSTVWY\n"; + } else { + return "ALPHABET" + + (this.name != null ? " " + name_as_text(this.name) : "") + + (this.like != null ? " " + this.like + "-LIKE" : "") + "\n" + + this.as_text() + "END ALPHABET\n"; + } +}; + +// Returns a table showing all the letters in the alphabet +Alphabet.prototype.as_table = function() { + "use strict"; + var i, j, row, th, td, aliases, equals, sym; + var table = document.createElement("table"); + // create the core symbol header + row = table.insertRow(table.rows.length); + th = document.createElement("th"); + th.appendChild(document.createTextNode("Symbol(s)")); + row.appendChild(th); + th = document.createElement("th"); + th.appendChild(document.createTextNode("Name")); + row.appendChild(th); + th = document.createElement("th"); + if (this.has_complement()) { + th.appendChild(document.createTextNode("Complement")); + } + row.appendChild(th); + // list the core symbols + for (i = 0; i < this.ncore; i++) { + row = table.insertRow(table.rows.length); + td = document.createElement("td"); + if (this.symbols[i].colour != null) { + td.style.color = '#' + this.symbols[i].colour; + } + td.appendChild(document.createTextNode(this.symbols[i].symbol)); + aliases = this.get_aliases(i); + if (aliases.length > 0) { + td.appendChild(document.createTextNode(' ' + aliases.split('').join(' '))); + } + row.appendChild(td); + td = document.createElement("td"); + if (this.symbols[i].name != null) { + td.appendChild(document.createTextNode(this.symbols[i].name)); + } + row.appendChild(td); + td = document.createElement("td"); + if (this.symbols[i].complement != null) { + td.style.color = this.get_colour(this.get_index(this.symbols[i].complement)); + td.appendChild(document.createTextNode(this.symbols[i].complement)); + } + row.appendChild(td); + } + // create the ambiguous symbol header + row = table.insertRow(table.rows.length); + th = document.createElement("th"); + th.appendChild(document.createTextNode("Symbol(s)")); + row.appendChild(th); + th = document.createElement("th"); + th.appendChild(document.createTextNode("Name")); + row.appendChild(th); + th = document.createElement("th"); + th.appendChild(document.createTextNode("Matches")); + row.appendChild(th); + // list the ambiguous symbols + for (i = this.ncore; i < this.symbols.length; i++) { + row = table.insertRow(table.rows.length); + td = document.createElement("td"); + if (this.symbols[i].colour != null) { + td.style.color = '#' + this.symbols[i].colour; + } + td.appendChild(document.createTextNode(this.symbols[i].symbol)); + aliases = this.get_aliases(i); + if (aliases.length > 0) { + td.appendChild(document.createTextNode(' ' + aliases.split('').join(' '))); + } + row.appendChild(td); + td = document.createElement("td"); + if (this.symbols[i].name != null) { + td.appendChild(document.createTextNode(this.symbols[i].name)); + } + row.appendChild(td); + td = document.createElement("td"); + equals = this.symbols[i].equals.split(''); + for (j = 0; j < equals.length; j++) { + if (j != 0) td.appendChild(document.createTextNode(' ')); + sym = document.createElement("span"); + sym.style.color = this.get_colour(this.get_index(equals[j])); + sym.appendChild(document.createTextNode(equals[j])); + td.appendChild(sym); + } + row.appendChild(td); + } + return table; +}; + +// returns a dictionary of the colours for EPS +Alphabet.prototype._as_eps_dict = function() { + "use strict"; + var i, sym, rgb; + var out = "/fullColourDict <<\n"; + for (i = 0; i < this.ncore; i++) { + sym = this.get_symbol(i); + sym = sym.replace(/\\/g, "\\\\"); + sym = sym.replace(/\(/g, "\\("); + sym = sym.replace(/\)/g, "\\)"); + rgb = this.get_rgb(i); + out += " (" + sym + ") [" + rgb.red.toFixed(4) + " " + rgb.green.toFixed(4) + " " + rgb.blue.toFixed(4) + "]\n"; + } + out += ">> def\n"; + out += "/mutedColourDict <<\n"; + for (i = 0; i < this.ncore; i++) { + sym = this.get_symbol(i); + sym = sym.replace(/\\/g, "\\\\"); + sym = sym.replace(/\(/g, "\\("); + sym = sym.replace(/\)/g, "\\)"); + rgb = Alphabet.lighten_colour(this.get_rgb(i)); + out += " (" + sym + ") [" + rgb.red.toFixed(4) + " " + rgb.green.toFixed(4) + " " + rgb.blue.toFixed(4) + "]\n"; + } + out += ">> def\n"; + return out; +}; + +// return the alphabet name or a list of primary symbols +Alphabet.prototype.toString = function() { + "use strict"; + if (this.name != null) { + return this.name; + } else { + return this.get_symbols(); + } +}; + +//~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ +// Helper functions +//~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ + +// Convert a colour specified in RGB colourspace values into LAB colourspace +Alphabet.rgb2lab = function(rgb) { + "use strict"; + var xyzHelper, labHelper; + // XYZ helper + xyzHelper = function(value) { + if (value > 0.0445) { + value = (value + 0.055) / 1.055; + value = Math.pow(value, 2.4); + } else { + value /= 12.92; + } + value *= 100; + return value; + }; + // lab helper + labHelper = function(value) { + if (value > 0.008856) { + value = Math.pow(value, 1.0 / 3.0); + } else { + value = (7.787 * value) + (16.0 / 116.0); + } + return value; + }; + // convert into XYZ colourspace + var c1, c2, c3; + if (typeof rgb == "number") { + c1 = xyzHelper(((rgb >> 16) & 0xFF) / 255.0); + c2 = xyzHelper(((rgb >> 8) & 0xFF) / 255.0); + c3 = xyzHelper((rgb & 0xFF) / 255.0); + } else { + c1 = xyzHelper(rgb.red); + c2 = xyzHelper(rgb.green); + c3 = xyzHelper(rgb.blue); + } + var x = (c1 * 0.4124) + (c2 * 0.3576) + (c3 * 0.1805); + var y = (c1 * 0.2126) + (c2 * 0.7152) + (c3 * 0.0722); + var z = (c1 * 0.0193) + (c2 * 0.1192) + (c3 * 0.9505); + // convert into Lab colourspace + c1 = labHelper(x / 95.047); + c2 = labHelper(y / 100.0); + c3 = labHelper(z / 108.883); + var l = (116.0 * c2) - 16; + var a = 500.0 * (c1 - c2); + var b = 200.0 * (c2 - c3); + return {"l": l, "a": a, "b": b}; +}; + +// Convert a colour specified in HSV colourspace into RGB colourspace +Alphabet.hsv2rgb = function(hue, sat, value, output_object) { + // achromatic (grey) + var r = value; + var g = value; + var b = value; + if (sat != 0) { + var h = hue / 60.0; + var i = Math.floor(h); + var f = h - i; + var p = value * (1.0 - sat); + var q = value * (1.0 - (sat * f)); + var t = value * (1.0 - (sat * (1.0 - f))); + if (i == 0) { + r = value; + g = t; + b = p; + } else if (i == 1) { + r = q; + g = value; + b = p; + } else if (i == 2) { + r = p; + g = value; + b = t; + } else if (i == 3) { + r = p; + g = q; + b = value; + } else if (i == 4) { + r = t; + g = p; + b = value; + } else { + r = value; + g = p; + b = q; + } + } + if (output_object) { + return {"red": r, "green": g, "blue": b}; + } else { + return (Math.floor(r * 255) << 15) | (Math.floor(g * 255) << 8) | (Math.floor(b * 255)); + } +}; + +// Calculate a distance score between two colours in LAB colourspace +Alphabet.lab_dist = function(lab1, lab2) { + var c1 = Math.sqrt((lab1.l * lab1.l) + (lab1.a * lab1.a)); + var c2 = Math.sqrt((lab2.l * lab2.l) + (lab2.a * lab2.a)); + var dc = c1 - c2; + var dl = lab1.l - lab2.l; + var da = lab1.a - lab2.a; + var db = lab1.b - lab2.b; + // we don't want NaN due to rounding errors so fudge things a bit... + var dh = 0; + var dh_squared = (da * da) + (db * db) - (dc * dc); + if (dh_squared > 0) { + dh = Math.sqrt(dh_squared); + } + var first = dl; + var second = dc / (1.0 + (0.045 * c1)); + var third = dh / (1.0 + (0.015 * c1)); + return Math.sqrt((first * first) + (second * second) + (third * third)); +}; + +// convert an RGB value into a HSL value +Alphabet.rgb2hsl = function(rgb) { + "use strict"; + var min, max, delta, h, s, l, r, g, b; + if (typeof rgb == "number") { + r = ((rgb >> 16) & 0xFF) / 255.0; + g = ((rgb >> 8) & 0xFF) / 255.0; + b = (rgb & 0xFF) / 255.0; + } else { + r = rgb.red; + g = rgb.green; + b = rgb.blue; + } + min = Math.min(r, g, b); + max = Math.max(r, g, b); + delta = max - min; + l = min + (delta / 2); + if (max == min) { + h = 0; // achromatic (grayscale) + s = 0; + } else { + if (l > 0.5) { + s = delta / (2 - max - min); + } else { + s = delta / (max + min); + } + if (max == r) { + h = (g - b) / delta; + if (g < b) h += 6; + } else if (max == g) { + h = ((b - r) / delta) + 2; + } else { + h = ((r - g) / delta) + 4; + } + h /= 6; + } + return {"h": h, "s": s, "l": l}; +}; + +// convert a HSL value into an RGB value +Alphabet.hsl2rgb = function(hsl, output_object) { + "use strict"; + function _hue(p, q, t) { + "use strict"; + if (t < 0) t += 1; + else if (t > 1) t -= 1; + if (t < (1.0 / 6.0)) { + return p + ((q - p) * 6.0 * t); + } else if (t < 0.5) { + return q; + } else if (t < (2.0 / 3.0)) { + return p + ((q - p) * ((2.0 / 3.0) - t) * 6.0); + } else { + return p; + } + } + var r, g, b, p, q; + if (hsl.s == 0) { + // achromatic (grayscale) + r = hsl.l; + g = hsl.l; + b = hsl.l; + } else { + if (hsl.l < 0.5) { + q = hsl.l * (1 + hsl.s); + } else { + q = hsl.l + hsl.s - (hsl.l * hsl.s); + } + p = (2 * hsl.l) - q; + r = _hue(p, q, hsl.h + (1.0 / 3.0)); + g = _hue(p, q, hsl.h); + b = _hue(p, q, hsl.h - (1.0 / 3.0)); + } + if (output_object) { + return {"red": r, "green": g, "blue": b}; + } else { + return (Math.floor(r * 255) << 15) | (Math.floor(g * 255) << 8) | (Math.floor(b * 255)); + } +}; + +Alphabet.lighten_colour = function(rgb) { + "use strict"; + var hsl = Alphabet.rgb2hsl(rgb); + hsl.l += (1.0 - hsl.l) * 2 / 3; + return Alphabet.hsl2rgb(hsl, typeof rgb != "number"); +}; + +//====================================================================== +// end Alphabet object +//====================================================================== + +//====================================================================== +// start StandardAlphabet object +//====================================================================== + +// an extension of the alphabet object to support some additional fields +// only present in standard alphabets. +var StandardAlphabet = function(enum_code, enum_name, alphabet_data) { + Alphabet.apply(this, [alphabet_data]); + this.enum_code = enum_code; + this.enum_name = enum_name; +}; +StandardAlphabet.prototype = Alphabet.prototype; +StandardAlphabet.prototype.constructor = StandardAlphabet; + +// A unique code for this standard alphabet. +// This code will be a power of 2 to enable creation of bitsets for +// a selection of standard alphabets. +StandardAlphabet.prototype.get_code = function() { + return this.enum_code; +}; + +// A unique name for this standard alphabet. +// this name will be all upper case and the same as the property that +// refers to this alphabet in the AlphStd collection. +StandardAlphabet.prototype.get_enum = function() { + return this.enum_name; +}; + +//====================================================================== +// end StandardAlphabet object +//====================================================================== + +// A collection of standard alphabets. +var AlphStd = { + RNA: new StandardAlphabet(1, "RNA", { + "name": "RNA", + "like": "RNA", + "ncore": 4, + "symbols": [ + {"symbol": "A", "name": "Adenine", "colour": "CC0000"}, + {"symbol": "C", "name": "Cytosine", "colour": "0000CC"}, + {"symbol": "G", "name": "Guanine", "colour": "FFB300"}, + {"symbol": "U", "name": "Uracil", "colour": "008000", + "aliases": "T"}, + {"symbol": "N", "name": "Any base", "equals": "ACGU", "aliases": "X."}, + {"symbol": "V", "name": "Not U", "equals": "ACG"}, + {"symbol": "H", "name": "Not G", "equals": "ACU"}, + {"symbol": "D", "name": "Not C", "equals": "AGU"}, + {"symbol": "B", "name": "Not A", "equals": "CGU"}, + {"symbol": "M", "name": "Amino", "equals": "AC"}, + {"symbol": "R", "name": "Purine", "equals": "AG"}, + {"symbol": "W", "name": "Weak", "equals": "AU"}, + {"symbol": "S", "name": "Strong", "equals": "CG"}, + {"symbol": "Y", "name": "Pyrimidine", "equals": "CU"}, + {"symbol": "K", "name": "Keto", "equals": "GU"} + ] + }), + DNA: new StandardAlphabet(2, "DNA", { + "name": "DNA", + "like": "DNA", + "ncore": 4, + "symbols": [ + {"symbol": "A", "name": "Adenine", "colour": "CC0000", "complement": "T"}, + {"symbol": "C", "name": "Cytosine", "colour": "0000CC", "complement": "G"}, + {"symbol": "G", "name": "Guanine", "colour": "FFB300", "complement": "C"}, + {"symbol": "T", "name": "Thymine", "colour": "008000", "complement": "A", + "aliases": "U"}, + {"symbol": "N", "name": "Any base", "equals": "ACGT", "aliases": "X."}, + {"symbol": "V", "name": "Not T", "equals": "ACG"}, + {"symbol": "H", "name": "Not G", "equals": "ACT"}, + {"symbol": "D", "name": "Not C", "equals": "AGT"}, + {"symbol": "B", "name": "Not A", "equals": "CGT"}, + {"symbol": "M", "name": "Amino", "equals": "AC"}, + {"symbol": "R", "name": "Purine", "equals": "AG"}, + {"symbol": "W", "name": "Weak", "equals": "AT"}, + {"symbol": "S", "name": "Strong", "equals": "CG"}, + {"symbol": "Y", "name": "Pyrimidine", "equals": "CT"}, + {"symbol": "K", "name": "Keto", "equals": "GT"} + ] + }), + PROTEIN: new StandardAlphabet(4, "PROTEIN", { + "name": "Protein", + "like": "PROTEIN", + "ncore": 20, + "symbols": [ + {"symbol": "A", "name": "Alanine", "colour": "0000CC"}, + {"symbol": "C", "name": "Cysteine", "colour": "0000CC"}, + {"symbol": "D", "name": "Aspartic acid", "colour": "FF00FF"}, + {"symbol": "E", "name": "Glutamic acid", "colour": "FF00FF"}, + {"symbol": "F", "name": "Phenylalanine", "colour": "0000CC"}, + {"symbol": "G", "name": "Glycine", "colour": "FFB300"}, + {"symbol": "H", "name": "Histidine", "colour": "FFCCCC"}, + {"symbol": "I", "name": "Isoleucine", "colour": "0000CC"}, + {"symbol": "K", "name": "Lysine", "colour": "CC0000"}, + {"symbol": "L", "name": "Leucine", "colour": "0000CC"}, + {"symbol": "M", "name": "Methionine", "colour": "0000CC"}, + {"symbol": "N", "name": "Asparagine", "colour": "008000"}, + {"symbol": "P", "name": "Proline", "colour": "FFFF00"}, + {"symbol": "Q", "name": "Glutamine", "colour": "008000"}, + {"symbol": "R", "name": "Arginine", "colour": "CC0000"}, + {"symbol": "S", "name": "Serine", "colour": "008000"}, + {"symbol": "T", "name": "Threonine", "colour": "008000"}, + {"symbol": "V", "name": "Valine", "colour": "0000CC"}, + {"symbol": "W", "name": "Tryptophan", "colour": "0000CC"}, + {"symbol": "Y", "name": "Tyrosine", "colour": "33E6CC"}, + {"symbol": "X", "name": "Any amino acid", "equals": "ACDEFGHIKLMNPQRSTVWY", "aliases": "*."}, + {"symbol": "B", "name": "Asparagine or Aspartic acid", "equals": "DN"}, + {"symbol": "Z", "name": "Glutamine or Glutamic acid", "equals": "EQ"}, + {"symbol": "J", "name": "Leucine or Isoleucine", "equals": "IL"} + ] + }) +}; + +//====================================================================== +// start Symbol object +//====================================================================== +var Symbol = function(alph_index, scale, alphabet) { + "use strict"; + //variable prototype + this.symbol = alphabet.get_symbol(alph_index); + this.scale = scale; + this.colour = alphabet.get_colour(alph_index); +}; + +Symbol.prototype.get_symbol = function() { + "use strict"; + return this.symbol; +}; + +Symbol.prototype.get_scale = function() { + "use strict"; + return this.scale; +}; + +Symbol.prototype.get_colour = function() { + "use strict"; + return this.colour; +}; + +Symbol.prototype.toString = function() { + "use strict"; + return this.symbol + " " + (Math.round(this.scale*1000)/10) + "%"; +}; + +function compare_symbol(sym1, sym2) { + "use strict"; + if (sym1.get_scale() < sym2.get_scale()) { + return -1; + } else if (sym1.get_scale() > sym2.get_scale()) { + return 1; + } else { + return 0; + } +} +//====================================================================== +// end Symbol object +//====================================================================== + +//====================================================================== +// start Pspm object +//====================================================================== +var Pspm = function(matrix, name, ltrim, rtrim, nsites, evalue, pssm, alt) { + "use strict"; + var row, col, data, row_sum, delta, evalue_re; + if (typeof name !== "string") { + name = ""; + } + this.name = name; + //construct + if (matrix instanceof Pspm) { + // copy constructor + this.alph_length = matrix.alph_length; + this.motif_length = matrix.motif_length; + this.name = matrix.name; + this.alt = matrix.alt; + this.nsites = matrix.nsites; + this.evalue = matrix.evalue; + this.ltrim = matrix.ltrim; + this.rtrim = matrix.rtrim; + this.pspm = []; + for (row = 0; row < matrix.motif_length; row++) { + this.pspm[row] = []; + for (col = 0; col < matrix.alph_length; col++) { + this.pspm[row][col] = matrix.pspm[row][col]; + } + } + if (matrix.pssm != null) { + this.pssm = []; + for (row = 0; row < matrix.motif_length; row++) { + this.pspm[row] = []; + for (col = 0; col < matrix.alph_length; col++) { + this.pssm[row][col] = matrix.pssm[row][col]; + } + } + } + } else { + // check parameters + if (ltrim == null) { + ltrim = 0; + } else if (typeof ltrim !== "number" || ltrim % 1 !== 0 || ltrim < 0) { + throw new Error("ltrim must be a non-negative integer, got: " + ltrim); + } + if (rtrim == null) { + rtrim = 0; + } else if (typeof rtrim !== "number" || rtrim % 1 !== 0 || rtrim < 0) { + throw new Error("rtrim must be a non-negative integer, got: " + rtrim); + } + if (nsites != null) { + if (typeof nsites !== "number" || nsites < 0) { + throw new Error("nsites must be a positive number, got: " + nsites); + } else if (nsites == 0) { + nsites = null; + } + } + if (evalue != null) { + if (typeof evalue === "number") { + if (evalue < 0) { + throw new Error("evalue must be a non-negative number, got: " + evalue); + } + } else if (typeof evalue === "string") { + evalue_re = /^((?:[+]?[0-9]*\.?[0-9]+(?:[eE][-+]?[0-9]+)?)|inf)$/; + if (!evalue_re.test(evalue)) { + throw new Error("evalue must be a non-negative number, got: " + evalue); + } + } else { + throw new Error("evalue must be a non-negative number, got: " + evalue); + } + } + // set properties + this.name = name; + this.alt = alt; + this.nsites = nsites; + this.evalue = evalue; + this.ltrim = ltrim; + this.rtrim = rtrim; + if (typeof matrix === "string") { + // string constructor + data = parse_pspm_string(matrix); + this.alph_length = data["alph_length"]; + this.motif_length = data["motif_length"]; + this.pspm = data["pspm"]; + if (this.evalue == null) { + if (data["evalue"] != null) { + this.evalue = data["evalue"]; + } else { + this.evalue = 0; + } + } + if (this.nsites == null) { + if (typeof data["nsites"] === "number") { + this.nsites = data["nsites"]; + } else { + this.nsites = 20; + } + } + } else { + // assume pspm is a nested array + this.motif_length = matrix.length; + this.alph_length = (matrix.length > 0 ? matrix[0].length : 0); + if (this.nsites == null) { + this.nsites = 20; + } + if (this.evalue == null) { + this.evalue = 0; + } + this.pspm = []; + // copy pspm and check + for (row = 0; row < this.motif_length; row++) { + if (this.alph_length != matrix[row].length) { + throw new Error("COLUMN_MISMATCH"); + } + this.pspm[row] = []; + row_sum = 0; + for (col = 0; col < this.alph_length; col++) { + this.pspm[row][col] = matrix[row][col]; + row_sum += this.pspm[row][col]; + } + delta = 0.1; + if (isNaN(row_sum) || (row_sum > 1 && (row_sum - 1) > delta) || + (row_sum < 1 && (1 - row_sum) > delta)) { + throw new Error("INVALID_SUM"); + } + } + // copy pssm + if (pssm != null) { + this.pssm = []; + for (row = 0; row < this.motif_length; row++) { + this.pssm[row] = []; + for (col = 0; col < this.alph_length; col++) { + this.pssm[row][col] = pssm[row][col]; + } + } + } + } + } +}; + +Pspm.prototype.copy = function() { + "use strict"; + return new Pspm(this); +}; + +Pspm.prototype.reverse = function() { + "use strict"; + var x, y, temp, temp_trim; + //reverse + x = 0; + y = this.motif_length-1; + while (x < y) { + temp = this.pspm[x]; + this.pspm[x] = this.pspm[y]; + this.pspm[y] = temp; + x++; + y--; + } + // reverse pssm (if defined) + if (typeof this.pssm !== "undefined") { + //reverse + x = 0; + y = this.motif_length-1; + while (x < y) { + temp = this.pssm[x]; + this.pspm[x] = this.pssm[y]; + this.pssm[y] = temp; + x++; + y--; + } + } + //swap triming + temp_trim = this.ltrim; + this.ltrim = this.rtrim; + this.rtrim = temp_trim; + return this; //allow function chaining... +}; + +Pspm.prototype.reverse_complement = function(alphabet) { + "use strict"; + var x, y, temp, i, row, c, temp_trim; + if (this.alph_length != alphabet.get_size_core()) { + throw new Error("The alphabet size does not match the size of the pspm."); + } + if (!alphabet.has_complement()) { + throw new Error("The specified alphabet can not be complemented."); + } + // reverse motif + this.reverse(); + //complement + for (x = 0; x < this.motif_length; x++) { + row = this.pspm[x]; + for (i = 0; i < row.length; i++) { + c = alphabet.get_complement(i); + if (c < i) continue; + temp = row[i]; + row[i] = row[c]; + row[c] = temp; + } + } + // complement pssm (if defined) + if (typeof this.pssm !== "undefined") { + //complement + for (x = 0; x < this.motif_length; x++) { + row = this.pssm[x]; + for (i = 0; i < row.length; i++) { + c = alphabet.get_complement(i); + if (c < i) continue; + temp = row[i]; + row[i] = row[c]; + row[c] = temp; + } + } + } + return this; //allow function chaining... +}; + +Pspm.prototype.get_stack = function(position, alphabet, ssc) { + "use strict"; + var row, stack_ic, alphabet_ic, stack, i, sym; + if (this.alph_length != alphabet.get_size_core()) { + throw new Error("The alphabet size does not match the size of the pspm."); + } + row = this.pspm[position]; + stack_ic = this.get_stack_ic(position, alphabet); + if (ssc) stack_ic -= this.get_error(alphabet); + alphabet_ic = alphabet.get_ic(); + stack = []; + for (i = 0; i < this.alph_length; i++) { + sym = new Symbol(i, row[i]*stack_ic/alphabet_ic, alphabet); + if (sym.get_scale() <= 0) { + continue; + } + stack.push(sym); + } + stack.sort(compare_symbol); + return stack; +}; + +Pspm.prototype.get_stack_ic = function(position, alphabet) { + "use strict"; + var row, H, i; + if (this.alph_length != alphabet.get_size_core()) { + throw new Error("The alphabet size does not match the size fo the pspm."); + } + row = this.pspm[position]; + H = 0; + for (i = 0; i < this.alph_length; i++) { + if (row[i] === 0) { + continue; + } + H -= (row[i] * (Math.log(row[i]) / Math.LN2)); + } + return alphabet.get_ic() - H; +}; + +Pspm.prototype.get_error = function(alphabet) { + "use strict"; + if (this.nsites === 0) { + return 0; + } + return (alphabet.get_size_core()-1) / (2 * Math.LN2 * this.nsites); +}; + +Pspm.prototype.get_motif_length = function() { + "use strict"; + return this.motif_length; +}; + +Pspm.prototype.get_alph_length = function() { + "use strict"; + return this.alph_length; +}; + +Pspm.prototype.get_left_trim = function() { + "use strict"; + return this.ltrim; +}; + +Pspm.prototype.get_right_trim = function() { + "use strict"; + return this.rtrim; +}; + +Pspm.prototype.as_best_match = function(alphabet) { + "use strict"; + var match, odds, best_odds, best_index; + var i, j; + match = ""; + for (i = 0; i < this.motif_length; i++) { + best_index = 0; + best_odds = this.pspm[i][0] / alphabet.get_bg_freq(0); + for (j = 1; j < this.alph_length; j++) { + odds = this.pspm[i][j] / alphabet.get_bg_freq(j); + if (odds > best_odds) { + best_odds = odds; + best_index = j; + } + } + match += alphabet.get_symbol(best_index); + } + return match; +}; + +Pspm.prototype.as_count_matrix = function() { + "use strict"; + var count, count_text, text; + var i, j; + text = ""; + for (i = 0; i < this.motif_length; i++) { + if (i !== 0) { + text += "\n"; + } + for (j = 0; j < this.alph_length; j++) { + if (j !== 0) { + text += " "; + } + count = Math.round(this.nsites * this.pspm[i][j]); + count_text = "" + count; + // pad up to length of 4 + if (count_text.length < 4) { + text += (new Array(5 - count_text.length)).join(" ") + count_text; + } else { + text += count_text; + } + } + } + return text; +}; + +Pspm.prototype.as_probability_matrix = function() { + "use strict"; + var text; + var i, j; + text = ""; + for (i = 0; i < this.motif_length; i++) { + if (i !== 0) { + text += "\n"; + } + for (j = 0; j < this.alph_length; j++) { + if (j !== 0) { + text += " "; + } + text += this.pspm[i][j].toFixed(6); + } + } + return text; +}; + +Pspm.prototype.as_score_matrix = function(alphabet, pseudo) { + "use strict"; + var me, score, out, row, col, score_text; + me = this; + if (typeof this.pssm === "undefined") { + if (!(typeof alphabet === "object" && alphabet != null && alphabet instanceof Alphabet)) { + throw new Error("The alphabet is required to generate the pssm."); + } + if (typeof pseudo === "undefined") { + pseudo = 0.01; + } else if (typeof pseudo !== "number" || pseudo < 0) { + throw new Error("Expected positive number for pseudocount"); + } + score = function(row, col) { + "use strict"; + var p, bg, p2; + p = me.pspm[row][col]; + bg = alphabet.get_bg_freq(col); + p2 = (p * me.nsites + bg * pseudo) / (me.nsites + pseudo); + return (p2 > 0 ? Math.round((Math.log(p2 / bg) / Math.LN2) * 100) : -10000); + }; + } else { + score = function(row, col) { + "use strict"; + return me.pssm[row][col]; + }; + } + out = ""; + for (row = 0; row < this.motif_length; row++) { + for (col = 0; col < this.alph_length; col++) { + if (col !== 0) { + out += " "; + } + score_text = "" + score(row, col); + // pad out to 6 characters + if (score_text.length < 6) { + out += (new Array(7 - score_text.length)).join(" ") + score_text; + } else { + out += score_text; + } + } + out += "\n"; + } + return out; +} + +Pspm.prototype.as_pspm = function() { + "use strict"; + return "letter-probability matrix: alength= " + this.alph_length + + " w= " + this.motif_length + " nsites= " + this.nsites + + " E= " + (typeof this.evalue === "number" ? + this.evalue.toExponential() : this.evalue) + "\n" + + this.as_probability_matrix(); +}; + +Pspm.prototype.as_pssm = function(alphabet, pseudo) { + "use strict"; + return "log-odds matrix: alength= " + this.alph_length + + " w= " + this.motif_length + + " E= " + (typeof this.evalue == "number" ? + this.evalue.toExponential() : this.evalue) + "\n" + + this.as_score_matrix(alphabet, pseudo); +}; + +Pspm.prototype.as_meme = function(options) { + var with_header, with_pspm, with_pssm, version, alphabet, bg_source, pseudocount, strands; + var out, alen, i; + // get the options + if (typeof options !== "object" || options === null) { + options = {}; + } + with_header = (typeof options["with_header"] === "boolean" ? options["with_header"] : false); + with_pspm = (typeof options["with_pspm"] === "boolean" ? options["with_pspm"] : false); + with_pssm = (typeof options["with_pssm"] === "boolean" ? options["with_pssm"] : false); + if (!with_pspm && !with_pssm) with_pspm = true; + if (with_header) { + if (typeof options["version"] === "string" && /^\d+(?:\.\d+){0,2}$/.test(options["version"])) { + version = options["version"]; + } else if (typeof options["version"] === "number") { + version = options["version"].toFixed(0); + } else { + version = "4"; + } + if (typeof options["strands"] === "number" && options["strands"] === 1) { + strands = 1; + } else { + strands = 2; + } + if (typeof options["bg_source"] === "string") { + bg_source = options["bg_source"]; + } else { + bg_source = "unknown source"; + } + if (typeof options["alphabet"] === "object" && options["alphabet"] != null + && options["alphabet"] instanceof Alphabet) { + alphabet = options["alphabet"]; + } else { + throw new Error("The alphabet is required to generate the header."); + } + } + // now create the output + out = ""; + if (with_header) { + out = "MEME version " + version + "\n\n"; + out += alphabet.as_meme() + "\n"; + if (alphabet.has_complement()) { // assume DNA has both strands unless otherwise specified + out += "strands: " + (strands === 1 ? "+" : "+ -") + "\n\n"; + } + out += "Background letter frequencies (from " + bg_source + "):\n"; + alen = alphabet.get_size_core(); + for (i = 0; i < alen; i++) { + if (i !== 0) { + if (i % 9 === 0) { // maximum of nine entries per line + out += "\n"; + } else { + out += " "; + } + } + out += alphabet.get_symbol(i) + " " + alphabet.get_bg_freq(i).toFixed(3); + } + } + out += "\n\n"; + out += "MOTIF " + this.name + (this.alt == null ? "" : " " + this.alt); + if (with_pssm) { + out += "\n\n"; + out += this.as_pssm(options["alphabet"], options["pseudocount"]); + } + if (with_pspm) { + out += "\n\n"; + out += this.as_pspm(); + } + return out; +} + +Pspm.prototype.toString = function() { + "use strict"; + var str, i, row; + str = ""; + for (i = 0; i < this.pspm.length; i++) { + row = this.pspm[i]; + str += row.join("\t") + "\n"; + } + return str; +}; + +function parse_pspm_properties(str) { + "use strict"; + var parts, i, eqpos, before, after, properties, prop, num, num_re; + num_re = /^((?:[+]?[0-9]*\.?[0-9]+(?:[eE][-+]?[0-9]+)?)|inf)$/; + parts = trim(str).split(/\s+/); + // split up words containing = + for (i = 0; i < parts.length;) { + eqpos = parts[i].indexOf("="); + if (eqpos != -1) { + before = parts[i].substr(0, eqpos); + after = parts[i].substr(eqpos+1); + if (before.length > 0 && after.length > 0) { + parts.splice(i, 1, before, "=", after); + i += 3; + } else if (before.length > 0) { + parts.splice(i, 1, before, "="); + i += 2; + } else if (after.length > 0) { + parts.splice(i, 1, "=", after); + i += 2; + } else { + parts.splice(i, 1, "="); + i++; + } + } else { + i++; + } + } + properties = {}; + for (i = 0; i < parts.length; i += 3) { + if (parts.length - i < 3) { + throw new Error("Expected PSPM property was incomplete. "+ + "Remaing parts are: " + parts.slice(i).join(" ")); + } + if (parts[i+1] !== "=") { + throw new Error("Expected '=' in PSPM property between key and " + + "value but got " + parts[i+1]); + } + prop = parts[i].toLowerCase(); + num = parts[i+2]; + if (!num_re.test(num)) { + throw new Error("Expected numeric value for PSPM property '" + + prop + "' but got '" + num + "'"); + } + properties[prop] = num; + } + return properties; +} + +function parse_pspm_string(pspm_string) { + "use strict"; + var header_re, lines, first_line, line_num, col_num, alph_length, + motif_length, nsites, evalue, pspm, i, line, match, props, parts, + j, prob; + header_re = /^letter-probability\s+matrix:(.*)$/i; + lines = pspm_string.split(/\n/); + first_line = true; + line_num = 0; + col_num = 0; + alph_length; + motif_length; + nsites; + evalue; + pspm = []; + for (i = 0; i < lines.length; i++) { + line = trim(lines[i]); + if (line.length === 0) { + continue; + } + // check the first line for a header though allow matrices without it + if (first_line) { + first_line = false; + match = header_re.exec(line); + if (match !== null) { + props = parse_pspm_properties(match[1]); + if (props.hasOwnProperty("alength")) { + alph_length = parseFloat(props["alength"]); + if (alph_length != 4 && alph_length != 20) { + throw new Error("PSPM property alength should be 4 or 20" + + " but got " + alph_length); + } + } + if (props.hasOwnProperty("w")) { + motif_length = parseFloat(props["w"]); + if (motif_length % 1 !== 0 || motif_length < 1) { + throw new Error("PSPM property w should be an integer larger " + + "than zero but got " + motif_length); + } + } + if (props.hasOwnProperty("nsites")) { + nsites = parseFloat(props["nsites"]); + if (nsites <= 0) { + throw new Error("PSPM property nsites should be larger than " + + "zero but got " + nsites); + } + } + if (props.hasOwnProperty("e")) { + evalue = props["e"]; + if (evalue < 0) { + throw new Error("PSPM property evalue should be " + + "non-negative but got " + evalue); + } + } + continue; + } + } + pspm[line_num] = []; + col_num = 0; + parts = line.split(/\s+/); + for (j = 0; j < parts.length; j++) { + prob = parseFloat(parts[j]); + if (prob != parts[j] || prob < 0 || prob > 1) { + throw new Error("Expected probability but got '" + parts[j] + "'"); + } + pspm[line_num][col_num] = prob; + col_num++; + } + line_num++; + } + if (typeof motif_length === "number") { + if (pspm.length != motif_length) { + throw new Error("Expected PSPM to have a motif length of " + + motif_length + " but it was actually " + pspm.length); + } + } else { + motif_length = pspm.length; + } + if (typeof alph_length !== "number") { + alph_length = pspm[0].length; + if (alph_length != 4 && alph_length != 20) { + throw new Error("Expected length of first row in the PSPM to be " + + "either 4 or 20 but got " + alph_length); + } + } + for (i = 0; i < pspm.length; i++) { + if (pspm[i].length != alph_length) { + throw new Error("Expected PSPM row " + i + " to have a length of " + + alph_length + " but the length was " + pspm[i].length); + } + } + return {"pspm": pspm, "motif_length": motif_length, + "alph_length": alph_length, "nsites": nsites, "evalue": evalue}; +} +//====================================================================== +// end Pspm object +//====================================================================== + +//====================================================================== +// start Logo object +//====================================================================== + +var Logo = function(alphabet, options) { + "use strict"; + this.alphabet = alphabet; + this.fine_text = ""; + this.x_axis = 1; + this.y_axis = true; + this.xlate_nsyms = 1; + this.xlate_start = null; + this.xlate_end = null; + this.pspm_list = []; + this.pspm_column = []; + this.rows = 0; + this.columns = 0; + if (typeof options === "string") { + // the old method signature had fine_text here so we support that + this.fine_text = options; + } else if (typeof options === "object" && options != null) { + this.fine_text = (typeof options.fine_text === "string" ? options.fine_text : ""); + this.x_axis = (typeof options.x_axis === "boolean" ? (options.x_axis ? 1 : 0) : 1); + if (options.x_axis_hidden != null && options.x_axis_hidden) this.x_axis = -1; + this.y_axis = (typeof options.y_axis === "boolean" ? options.y_axis : true); + this.xlate_nsyms = (typeof options.xlate_nsyms === "number" ? options.xlate_nsyms : this.xlate_nsyms); + this.xlate_start = (typeof options.xlate_start === "number" ? options.xlate_start : this.xlate_start); + this.xlate_end = (typeof options.xlate_end === "number" ? options.xlate_end : this.xlate_end); + } +}; + +Logo.prototype.add_pspm = function(pspm, column) { + "use strict"; + var col; + if (typeof column === "undefined") { + column = 0; + } else if (column < 0) { + throw new Error("Column index out of bounds."); + } + this.pspm_list[this.rows] = pspm; + this.pspm_column[this.rows] = column; + this.rows++; + col = column + pspm.get_motif_length(); + if (col > this.columns) { + this.columns = col; + } +}; + +Logo.prototype.get_columns = function() { + "use strict"; + return this.columns; +}; + +Logo.prototype.get_xlate_nsyms = function() { + "use strict"; + return this.xlate_nsyms; +}; + +Logo.prototype.get_xlate_start = function() { + "use strict"; + return (this.xlate_start != null ? this.xlate_start : 0); +}; + +Logo.prototype.get_xlate_end = function() { + "use strict"; + return (this.xlate_end != null ? this.xlate_end : this.columns * this.xlate_nsyms); +}; + +Logo.prototype.get_xlate_columns = function() { + "use strict"; + return this.get_xlate_end() - this.get_xlate_start(); +}; + +Logo.prototype.get_rows = function() { + "use strict"; + return this.rows; +}; + +Logo.prototype.get_pspm = function(row_index) { + "use strict"; + if (row_index < 0 || row_index >= this.rows) { + throw new Error("INDEX_OUT_OF_BOUNDS"); + } + return this.pspm_list[row_index]; +}; + +Logo.prototype.get_offset = function(row_index) { + "use strict"; + if (row_index < 0 || row_index >= this.rows) { + throw new Error("INDEX_OUT_OF_BOUNDS"); + } + return this.pspm_column[row_index]; +}; + +Logo.prototype._as_eps_data = function(ssc, errbars) { + var i, j, pos, stack_pos, pspm, stack, sym, out; + out = ""; + for (i = 0; i < this.rows; i++) { + out += "\nStartLine\n"; + // Indent + for (j = 0; j < this.pspm_column[i]; j++) { + out += "() startstack\nendstack\n\n"; + } + pspm = this.pspm_list[i]; + if (pspm.get_left_trim() > 0) { + out += "MuteColour\nDrawTrimEdge\n" + pspm.get_left_trim() + " DrawTrimBg\n"; + } + for (pos = 0; pos < pspm.get_motif_length(); pos++) { + if (pos != 0 && pos == pspm.get_left_trim()) { // enable full colour + out += "DrawTrimEdge\nRestoreColour\n"; + } else if (pos == (pspm.get_motif_length() - pspm.get_right_trim())) { + out += "MuteColour\n" + pspm.get_right_trim() + " DrawTrimBg\n"; + } + out += "(" + (pos + 1) + ") startstack\n"; + stack = pspm.get_stack(pos, this.alphabet, ssc); + for (stack_pos = 0; stack_pos < stack.length; stack_pos++) { + sym = stack[stack_pos]; + out += " " + (sym.get_scale() * this.alphabet.get_ic()) + " (" + sym.get_symbol() + ") numchar\n"; + } + if (errbars) { + out += " " + pspm.get_error(this.alphabet) + " Ibeam\n"; + } + out += "endstack\n\n"; + } + if (pspm.get_right_trim() > 0 || pspm.get_left_trim() == pspm.get_motif_length()) { + out += "RestoreColour\n"; + } + out += "EndLine\n"; + } + return out; +}; + +Logo.prototype.as_eps = function(options) { + "use strict"; + if (this.xlate_nsyms != 1) throw new Error("Unsupported setting xlate_nsyms for EPS"); + if (this.xlate_start != null) throw new Error("Unsupported setting xlate_start for EPS"); + if (this.xlate_end != null) throw new Error("Unsupported setting xlate_end for EPS"); + + var LOGOHEIGHT = 7.5; // default height of line in cm + var cm2pts, height, width, now, ssc, errbars; + if (typeof options === "undefined") { + options = {}; + } + cm2pts = 72 / 2.54; + if (typeof options.logo_height == "number") { + height = options.logo_height; + } else { + height = LOGOHEIGHT * this.rows; + } + if (typeof options.logo_width == "number") { + width = options.logo_width; + } else { + width = this.columns + 2; + } + now = new Date(); + ssc = (typeof options.ssc == "boolean" ? options.ssc : false); + errbars = (typeof options.show_error_bar == "boolean" ? options.show_error_bar : ssc); + var values = { + "LOGOHEIGHT": height, + "LOGOWIDTH": width, + "BOUNDINGHEIGHT": Math.round(height * cm2pts), + "BOUNDINGWIDTH": Math.round(width * cm2pts), + "LOGOLINEHEIGHT": (height / this.rows), + "CHARSPERLINE": this.columns, + "BARBITS": this.alphabet.get_ic(), + "LOGOTYPE": (this.alphabet.has_complement() ? "NA" : "AA"), + "CREATIONDATE": now.getDate() + "." + (now.getMonth() + 1) + "." + now.getFullYear() + " " + now.getHours() + ":" + now.getMinutes() + ":" + now.getSeconds(), + "ERRORBARFRACTION": (typeof options.error_bar_fraction == "number" ? options.error_bar_fraction : 1.0), + "TICBITS": (typeof options.ticbits == "number" ? options.ticbits : 1.0), + "TITLE": (typeof options.title == "string" ? options.title : ""), + "FINEPRINT": (typeof options.fineprint == "string" ? options.fineprint : this.fine_text), + "XAXISLABEL": (typeof options.xaxislabel == "string" ? options.xaxislabel : ""), + "YAXISLABEL": (typeof options.yaxislabel == "string" ? options.yaxislabel : "bits"), + "SSC": ssc, + "YAXIS": (typeof options.show_y_axis == "boolean" ? options.show_y_axis : this.y_axis), + "SHOWENDS": (typeof options.show_ends == "boolean" ? options.show_ends : false), + "ERRBAR": errbars, + "OUTLINE": (typeof options.show_outline == "boolean" ? options.show_outline : false), + "NUMBERING": (typeof options.show_numbering == "boolean" ? options.show_numbering : this.x_axis != 0), + "SHOWINGBOX": (typeof options.show_box == "boolean" ? options.show_box : false), + "CREATOR": (typeof options.creator == "string" ? options.creator : "motif_logo.js"), + "FONTSIZE": (typeof options.label_font_size == "number" ? options.label_font_size : 12), + "TITLEFONTSIZE": (typeof options.title_font_size == "number" ? options.title_font_size : 12), + "SMALLFONTSIZE": (typeof options.small_font_size == "number" ? options.small_font_size : 6), + "TOPMARGIN" : (typeof options.top_margin == "number" ? options.top_margin : 0.9), + "BOTTOMMARGIN": (typeof options.bottom_margin == "number" ? options.bottom_margin : 0.9), + "COLORDICT": this.alphabet._as_eps_dict(), + "DATA": this._as_eps_data(ssc, errbars) + }; + // now this requires that the script containing the template has been imported! + return motif_logo_template(values); +}; + +//====================================================================== +// end Logo object +//====================================================================== + +// calculate the exact size (in pixels) of an object drawn on the +// canvas assuming that the background of the canvas is transparent. +function canvas_bounds(ctx, cwidth, cheight) { + "use strict"; + var data, r, c, top_line, bottom_line, left_line, right_line, + txt_width, txt_height; + + // extract the image data + data = ctx.getImageData(0, 0, cwidth, cheight).data; + + // set initial values + top_line = -1; bottom_line = -1; left_line = -1; right_line = -1; + txt_width = 0; txt_height = 0; + + // Find the top-most line with a non-transparent pixel + for (r = 0; r < cheight; r++) { + for (c = 0; c < cwidth; c++) { + if (data[r * cwidth * 4 + c * 4 + 3]) { + top_line = r; + break; + } + } + if (top_line != -1) { + break; + } + } + + // Only bother looking if we found at least one set pixel... + if (top_line != -1) { + + //find the last line with a non-transparent pixel + for (r = cheight-1; r >= top_line; r--) { + for(c = 0; c < cwidth; c++) { + if(data[r * cwidth * 4 + c * 4 + 3]) { + bottom_line = r; + break; + } + } + if (bottom_line != -1) { + break; + } + } + // calculate height + txt_height = bottom_line - top_line + 1; + + // Find the left-most line with a non-transparent pixel + for (c = 0; c < cwidth; c++) { + for (r = top_line; r <= bottom_line; r++) { + if (data[r * cwidth * 4 + c * 4 + 3]) { + left_line = c; + break; + } + } + if (left_line != -1) { + break; + } + } + + //find the right most line with a non-transparent pixel + for (c = cwidth-1; c >= left_line; c--) { + for(r = top_line; r <= bottom_line; r++) { + if(data[r * cwidth * 4 + c * 4 + 3]) { + right_line = c; + break; + } + } + if (right_line != -1) { + break; + } + } + txt_width = right_line - left_line + 1; + } + + //return the bounds + return {bound_top: top_line, bound_bottom: bottom_line, + bound_left: left_line, bound_right: right_line, width: txt_width, + height: txt_height}; +} + +//====================================================================== +// start RasterizedAlphabet +//====================================================================== + +// Rasterize Alphabet +// 1) Measure width of text at default font for all symbols in alphabet +// 2) sort in width ascending +// 3) Drop the top and bottom 10% (designed to ignore outliers like 'W' and 'I') +// 4) Calculate the average as the maximum scaling factor (designed to stop I becoming a rectangular blob). +// 5) Assume scale of zero would result in width of zero, interpolate scale required to make perfect width font +// 6) Draw text onto temp canvas at calculated scale +// 7) Find bounds of drawn text +// 8) Paint on to another canvas at the desired height (but only scaling width to fit if larger). +var RasterizedAlphabet = function(alphabet, logo_scale, font, width) { + "use strict"; + var default_size, safety_pad, canvas, ctx, middle, baseline, widths, sizes, + i, sym, size, tenpercent, avg_width, scale, + target_width, target_height; + //variable prototypes + this.alphabet = alphabet; + this.scale = logo_scale; + this.sym_cache = {}; + this.stack_num_cache = []; + this.scale_num_cache = []; + // size of canvas + default_size = 60; // size of measuring canvas + safety_pad = 20; // pixels to pad around so we don't miss the edges + // create a canvas to do our measuring + canvas = document.createElement("canvas"); + if (!canvas.getContext) throw new Error("No canvas support"); + canvas.width = default_size + 2 * safety_pad; + canvas.height = default_size + 2 * safety_pad; + middle = Math.round(canvas.width / 2); + baseline = Math.round(canvas.height - safety_pad); + ctx = canvas.getContext('2d'); + if (!supports_text(ctx)) throw new Error("Canvas does not support text"); + ctx.font = font; + ctx.textAlign = "center"; + ctx.translate(middle, baseline); + // list of widths + widths = []; + sizes = []; + //now measure each letter in the alphabet + for (i = 0; i < alphabet.get_size_core(); ++i) { + // reset the canvas + ctx.clearRect(0, 0, canvas.width, canvas.height); + ctx.fillStyle = alphabet.get_colour(i); + // draw the test text + ctx.fillText(alphabet.get_symbol(i), 0, 0); + //measure + size = canvas_bounds(ctx, canvas.width, canvas.height); + if (size.width === 0) throw new Error("Invisible symbol!"); + widths.push(size.width); + sizes[i] = size; + } + //sort the widths + widths.sort(function(a,b) {return a - b;}); + //drop 10% of the items off each end + tenpercent = Math.floor(widths.length / 10); + for (i = 0; i < tenpercent; ++i) { + widths.pop(); + widths.shift(); + } + //calculate average width + avg_width = 0; + for (i = 0; i < widths.length; ++i) { + avg_width += widths[i]; + } + avg_width /= widths.length; + // calculate the target width + target_width = width * this.scale * 2; + // calculate scales + for (i = 0; i < alphabet.get_size_core(); ++i) { + sym = alphabet.get_symbol(i); + size = sizes[i]; + // calculate scale + scale = target_width / Math.max(avg_width, size.width); + // estimate scaled height + target_height = size.height * scale; + // create an appropriately sized canvas + canvas = document.createElement("canvas"); + canvas.width = target_width; + canvas.height = target_height + safety_pad * 2; + // calculate the middle + middle = Math.round(canvas.width / 2); + // calculate the baseline + baseline = Math.round(canvas.height - safety_pad); + // get the context and prepare to draw the rasterized text + ctx = canvas.getContext('2d'); + ctx.font = font; + ctx.fillStyle = alphabet.get_colour(i); + ctx.textAlign = "center"; + ctx.translate(middle, baseline); + ctx.save(); + ctx.scale(scale, scale); + // draw the text + ctx.fillText(sym, 0, 0); + ctx.restore(); + this.sym_cache[sym] = {"image": canvas, "size": canvas_bounds(ctx, canvas.width, canvas.height)}; + } +}; + +RasterizedAlphabet.prototype.get_alphabet = function() { + return this.alphabet; +}; + +RasterizedAlphabet.prototype.get_scale = function() { + return this.scale; +}; + +RasterizedAlphabet.prototype.draw_stack_sym = function(ctx, letter, dx, dy, dWidth, dHeight) { + "use strict"; + var entry, image, size; + entry = this.sym_cache[letter]; + image = entry.image; + size = entry.size; + ctx.drawImage(image, 0, size.bound_top -1, image.width, size.height+1, dx, dy, dWidth, dHeight); +}; + +RasterizedAlphabet.prototype.draw_stack_num = function(ctx, font, stack_width, index) { + var image, image_ctx, text_length; + if (index >= this.stack_num_cache.length) { + image = document.createElement("canvas"); + // measure the text + image_ctx = image.getContext('2d'); + image_ctx.save(); + image_ctx.font = font; + text_length = image_ctx.measureText("" + (index + 1)).width; + image_ctx.restore(); + // resize the canvas to fit + image.width = Math.ceil(stack_width); + image.height = Math.ceil(text_length); + // draw the text + image_ctx = image.getContext('2d'); + image_ctx.translate(Math.round(stack_width / 2), 0); + image_ctx.font = font; + image_ctx.textBaseline = "middle"; + image_ctx.textAlign = "right"; + image_ctx.rotate(-(Math.PI / 2)); + image_ctx.fillText("" + (index + 1), 0, 0); + this.stack_num_cache[index] = image; + } else { + image = this.stack_num_cache[index]; + } + ctx.drawImage(image, 0, 0); +} + +RasterizedAlphabet.prototype.draw_scale_num = function(ctx, font, num) { + var image, image_ctx, text_size, m_length; + if (num >= this.scale_num_cache.length) { + image = document.createElement("canvas"); + // measure the text + image_ctx = image.getContext('2d'); + image_ctx.font = font; + text_size = image_ctx.measureText("" + num); + if (text_size.actualBoundingBoxAscent && text_size.actualBoundingBoxDesent) { + // resize the canvas to fit + image.width = Math.ceil(text_size.width); + image.height = Math.ceil(text_size.actualBoundingBoxAscent + text_size.actualBoundingBoxDesent); + // draw the text + image_ctx = image.getContext('2d'); + image_ctx.font = font; + image_ctx.textAlign = "right"; + image_ctx.fillText("" + num, image.width, text_size.actualBoundingBoxAscent); + } else { + // measure width of 'm' to approximate height, we double it later anyway + m_length = image_ctx.measureText("m").width; + // resize the canvas to fit + image.width = Math.ceil(text_size.width); + image.height = Math.ceil(2 * m_length); + // draw the text + image_ctx = image.getContext('2d'); + image_ctx.font = font; + image_ctx.textAlign = "right"; + image_ctx.textBaseline = "middle"; + image_ctx.fillText("" + num, image.width, m_length); + } + this.scale_num_cache[num] = image; + } else { + image = this.scale_num_cache[num]; + } + ctx.drawImage(image, -image.width, -Math.round(image.height / 2)) +} + +//====================================================================== +// end RasterizedAlphabet +//====================================================================== + +//====================================================================== +// start LogoMetrics object +//====================================================================== + +var LogoMetrics = function(ctx, logo_columns, logo_rows, has_names, has_finetext, x_axis, y_axis) { + "use strict"; + var i, row_height; + //variable prototypes + this.pad_top = (has_names ? 5 : 0); + this.pad_left = (y_axis ? 10 : 0); + this.pad_right = (has_finetext ? 15 : 0); + this.pad_bottom = 0; + this.pad_middle = 20; + this.name_height = 14; + this.name_font = "bold " + this.name_height + "px Times, sans-serif"; + this.name_spacer = 0; + this.y_axis = y_axis; + this.y_label = "bits"; + this.y_label_height = 12; + this.y_label_font = "bold " + this.y_label_height + "px Helvetica, sans-serif"; + this.y_label_spacer = 3; + this.y_num_height = 12; + this.y_num_width = 0; + this.y_num_font = "bold " + this.y_num_height + "px Helvetica, sans-serif"; + this.y_tic_width = 5; + this.stack_pad_left = 0; + this.stack_font = "bold 25px Helvetica, sans-serif"; + this.stack_height = 90; + this.stack_width = 26; + this.stacks_pad_right = 5; + this.x_axis = x_axis; + this.x_num_above = 2; + this.x_num_height = 12; + this.x_num_width = 0; + this.x_num_font = "bold " + this.x_num_height + "px Helvetica, sans-serif"; + this.fine_txt_height = 6; + this.fine_txt_above = 2; + this.fine_txt_font = "normal " + this.fine_txt_height + "px Helvetica, sans-serif"; + this.letter_metrics = new Array(); + this.summed_width = 0; + this.summed_height = 0; + //calculate the width of the y axis numbers + ctx.font = this.y_num_font; + for (i = 0; i <= 2; i++) { + this.y_num_width = Math.max(this.y_num_width, ctx.measureText("" + i).width); + } + //calculate the width of the x axis numbers (but they are rotated so it becomes height) + if (x_axis == 1) { + ctx.font = this.x_num_font; + for (i = 1; i <= logo_columns; i++) { + this.x_num_width = Math.max(this.x_num_width, ctx.measureText("" + i).width); + } + } else if (x_axis == 0) { + this.x_num_height = 4; + this.x_num_width = 4; + } else { + this.x_num_height = 0; + this.x_num_width = 0; + } + + //calculate how much vertical space we want to draw this + //first we add the padding at the top and bottom since that's always there + this.summed_height += this.pad_top + this.pad_bottom; + //all except the last row have the same amount of space allocated to them + if (logo_rows > 1) { + row_height = this.stack_height + this.pad_middle; + if (has_names) { + row_height += this.name_height; + //the label is allowed to overlap into the spacer + row_height += Math.max(this.y_num_height/2, this.name_spacer); + //the label is allowed to overlap the space used by the other label + row_height += Math.max(this.y_num_height/2, this.x_num_height + this.x_num_above); + } else { + row_height += this.y_num_height/2; + //the label is allowed to overlap the space used by the other label + row_height += Math.max(this.y_num_height/2, this.x_num_height + this.x_num_above); + } + this.summed_height += row_height * (logo_rows - 1); + } + //the last row has the name and fine text below it but no padding + this.summed_height += this.stack_height + (this.y_axis ? this.y_num_height/2 : 0); + + var fine_txt_total = (has_finetext ? this.fine_txt_height + this.fine_txt_above : 0); + if (has_names) { + this.summed_height += fine_txt_total + this.name_height; + this.summed_height += Math.max((this.y_axis ? this.y_num_height/2 : 0), + this.x_num_height + this.x_num_above + this.name_spacer); + } else { + this.summed_height += Math.max((this.y_axis ? this.y_num_height/2 : 0), + this.x_num_height + this.x_num_above + fine_txt_total); + } + + //calculate how much horizontal space we want to draw this + //first add the padding at the left and right since that's always there + this.summed_width += this.pad_left + this.pad_right; + if (this.y_axis) { + //add on the space for the y-axis label + this.summed_width += this.y_label_height + this.y_label_spacer; + //add on the space for the y-axis + this.summed_width += this.y_num_width + this.y_tic_width; + } + //add on the space for the stacks + this.summed_width += (this.stack_pad_left + this.stack_width) * logo_columns; + //add on the padding after the stacks (an offset from the fine text) + this.summed_width += this.stacks_pad_right; + +}; + +//====================================================================== +// end LogoMetrics object +//====================================================================== + +//found this trick at http://talideon.com/weblog/2005/02/detecting-broken-images-js.cfm +function image_ok(img) { + "use strict"; + // During the onload event, IE correctly identifies any images that + // weren't downloaded as not complete. Others should too. Gecko-based + // browsers act like NS4 in that they report this incorrectly. + if (!img.complete) { + return false; + } + // However, they do have two very useful properties: naturalWidth and + // naturalHeight. These give the true size of the image. If it failed + // to load, either of these should be zero. + if (typeof img.naturalWidth !== "undefined" && img.naturalWidth === 0) { + return false; + } + // No other way of checking: assume it's ok. + return true; +} + +function supports_text(ctx) { + "use strict"; + if (!ctx.fillText) { + return false; + } + if (!ctx.measureText) { + return false; + } + return true; +} + +//draws the scale, returns the width +function draw_scale(ctx, metrics, alphabet_ic, raster) { + "use strict"; + var tic_height, i; + tic_height = metrics.stack_height / alphabet_ic; + ctx.save(); + ctx.translate(metrics.y_label_height, metrics.y_num_height/2); + //draw the axis label + ctx.save(); + ctx.font = metrics.y_label_font; + ctx.translate(0, metrics.stack_height/2); + ctx.rotate(-(Math.PI / 2)); + ctx.textAlign = "center"; + ctx.fillText("bits", 0, 0); + ctx.restore(); + + ctx.translate(metrics.y_label_spacer + metrics.y_num_width, 0); + + //draw the axis tics + ctx.save(); + ctx.translate(0, metrics.stack_height); + for (i = 0; i <= alphabet_ic; i++) { + //draw the number + ctx.save(); + ctx.translate(-1, 0); + raster.draw_scale_num(ctx, metrics.y_num_font, i); + ctx.restore(); + //draw the tic + ctx.fillRect(0, -1, metrics.y_tic_width, 2); + //prepare for next tic + ctx.translate(0, -tic_height); + } + ctx.restore(); + + ctx.fillRect(metrics.y_tic_width - 2, 0, 2, metrics.stack_height) + + ctx.restore(); +} + +function draw_stack_num(ctx, metrics, row_index, raster) { + "use strict"; + ctx.save(); + ctx.translate(0, Math.round(metrics.stack_height + metrics.x_num_above)); + if (metrics.x_axis == 1) { + raster.draw_stack_num(ctx, metrics.x_num_font, metrics.stack_width, row_index); + } else if (metrics.x_axis == 0) { + // draw dots instead of the numbers (good for small logos) + ctx.beginPath(); + var radius = Math.round(metrics.x_num_height / 2); + ctx.arc(Math.round(metrics.stack_width / 2), radius, radius, 0, 2 * Math.PI, false); + ctx.fill(); + } + ctx.restore(); +} + +function draw_stack(ctx, metrics, symbols, raster) { + "use strict"; + var preferred_pad, sym_min, i, sym, sym_height, pad; + preferred_pad = 0; + sym_min = 5; + + ctx.save();//1 + ctx.translate(0, metrics.stack_height); + for (i = 0; i < symbols.length; i++) { + sym = symbols[i]; + sym_height = metrics.stack_height * sym.get_scale(); + + pad = preferred_pad; + if (sym_height - pad < sym_min) { + pad = Math.min(pad, Math.max(0, sym_height - sym_min)); + } + sym_height -= pad; + + //translate to the correct position + ctx.translate(0, -(pad/2 + sym_height)); + + //draw + raster.draw_stack_sym(ctx, sym.get_symbol(), 0, 0, metrics.stack_width, sym_height); + //translate past the padding + ctx.translate(0, -(pad/2)); + } + ctx.restore();//1 +} + +function draw_dashed_line(ctx, pattern, start, x1, y1, x2, y2) { + "use strict"; + var x, y, len, i, dx, dy, tlen, theta, mulx, muly, lx, ly; + dx = x2 - x1; + dy = y2 - y1; + tlen = Math.pow(dx*dx + dy*dy, 0.5); + theta = Math.atan2(dy,dx); + mulx = Math.cos(theta); + muly = Math.sin(theta); + lx = []; + ly = []; + for (i = 0; i < pattern; ++i) { + lx.push(pattern[i] * mulx); + ly.push(pattern[i] * muly); + } + i = start; + x = x1; + y = y1; + len = 0; + ctx.beginPath(); + while (len + pattern[i] < tlen) { + ctx.moveTo(x, y); + x += lx[i]; + y += ly[i]; + ctx.lineTo(x, y); + len += pattern[i]; + i = (i + 1) % pattern.length; + x += lx[i]; + y += ly[i]; + len += pattern[i]; + i = (i + 1) % pattern.length; + } + if (len < tlen) { + ctx.moveTo(x, y); + x += mulx * (tlen - len); + y += muly * (tlen - len); + ctx.lineTo(x, y); + } + ctx.stroke(); +} + +function draw_trim_background(ctx, metrics, left_start, left_end, left_divider, right_start, right_end, right_divider) { + "use strict"; + var left_size = left_end - left_start; + var right_size = right_end - right_start; + var line_x; + + ctx.save();//s8 + ctx.fillStyle = "rgb(240, 240, 240)"; + if (left_size > 0) { + ctx.fillRect(left_start * metrics.stack_width, 0, left_size * metrics.stack_width, metrics.stack_height); + } + if (right_size > 0) { + ctx.fillRect(right_start * metrics.stack_width, 0, right_size * metrics.stack_width, metrics.stack_height); + } + ctx.fillStyle = "rgb(51, 51, 51)"; + if (left_size > 0 && left_divider) { + line_x = (left_end * metrics.stack_width) - 0.5; + draw_dashed_line(ctx, [3], 0, line_x, 0, line_x, metrics.stack_height); + } + if (right_size > 0 && right_divider) { + line_x = (right_start * metrics.stack_width) + 0.5; + draw_dashed_line(ctx, [3], 0, line_x, 0, line_x, metrics.stack_height); + } + ctx.restore();//s8 +} + +function size_logo_on_canvas(logo, canvas, show_names, scale) { + "use strict"; + var draw_name, draw_finetext, metrics; + draw_name = (typeof show_names === "boolean" ? show_names : (logo.get_rows() > 1)); + draw_finetext = (logo.fine_text.length > 0); + if (canvas.width !== 0 && canvas.height !== 0) { + return; + } + metrics = new LogoMetrics(canvas.getContext('2d'), + logo.get_xlate_columns(), logo.get_rows(), draw_name, draw_finetext, logo.x_axis, logo.y_axis); + if (typeof scale == "number") { + //resize the canvas to fit the scaled logo + canvas.width = metrics.summed_width * scale; + canvas.height = metrics.summed_height * scale; + } else { + if (canvas.width === 0 && canvas.height === 0) { + canvas.width = metrics.summed_width; + canvas.height = metrics.summed_height; + } else if (canvas.width === 0) { + canvas.width = metrics.summed_width * (canvas.height / metrics.summed_height); + } else if (canvas.height === 0) { + canvas.height = metrics.summed_height * (canvas.width / metrics.summed_width); + } + } +} + +function draw_logo_on_canvas(logo, canvas, show_names, scale) { + "use strict"; + var i, draw_name, draw_finetext, ctx, metrics, raster, pspm_i, pspm, + offset, col_index, motif_position, ssc; + ssc = false; + draw_name = (typeof show_names === "boolean" ? show_names : (logo.get_rows() > 1)); + draw_finetext = (logo.fine_text.length > 0); + ctx = canvas.getContext('2d'); + //assume that the user wants the canvas scaled equally so calculate what the best width for this image should be + metrics = new LogoMetrics(ctx, logo.get_xlate_columns(), logo.get_rows(), draw_name, draw_finetext, logo.x_axis, logo.y_axis); + if (typeof scale == "number") { + //resize the canvas to fit the scaled logo + canvas.width = metrics.summed_width * scale; + canvas.height = metrics.summed_height * scale; + } else { + if (canvas.width === 0 && canvas.height === 0) { + scale = 1; + canvas.width = metrics.summed_width; + canvas.height = metrics.summed_height; + } else if (canvas.width === 0) { + scale = canvas.height / metrics.summed_height; + canvas.width = metrics.summed_width * scale; + } else if (canvas.height === 0) { + scale = canvas.width / metrics.summed_width; + canvas.height = metrics.summed_height * scale; + } else { + scale = Math.min(canvas.width / metrics.summed_width, canvas.height / metrics.summed_height); + } + } + // cache the raster based on the assumption that we will be drawing a lot + // of logos the same size and alphabet + if (typeof draw_logo_on_canvas.raster_cache === "undefined") { + draw_logo_on_canvas.raster_cache = []; + } + for (i = 0; i < draw_logo_on_canvas.raster_cache.length; i++) { + raster = draw_logo_on_canvas.raster_cache[i]; + if (raster.get_alphabet().equals(logo.alphabet) && + Math.abs(raster.get_scale() - scale) < 0.1) break; + raster = null; + } + if (raster == null) { + raster = new RasterizedAlphabet(logo.alphabet, scale, metrics.stack_font, metrics.stack_width); + draw_logo_on_canvas.raster_cache.push(raster); + } + ctx = canvas.getContext('2d'); + ctx.save();//s1 + ctx.scale(scale, scale); + ctx.save();//s2 + ctx.save();//s7 + //create margin + ctx.translate(Math.round(metrics.pad_left), Math.round(metrics.pad_top)); + for (pspm_i = 0; pspm_i < logo.get_rows(); ++pspm_i) { + pspm = logo.get_pspm(pspm_i); + offset = logo.get_offset(pspm_i); + //optionally draw name if this isn't the last row or is the only row + if (draw_name && (logo.get_rows() == 1 || pspm_i != (logo.get_rows()-1))) { + ctx.save();//s4 + ctx.translate(Math.round(metrics.summed_width/2), Math.round(metrics.name_height)); + ctx.font = metrics.name_font; + ctx.textAlign = "center"; + ctx.fillText(pspm.name, 0, 0); + ctx.restore();//s4 + ctx.translate(0, Math.round(metrics.name_height + + Math.min(0, metrics.name_spacer - metrics.y_num_height/2))); + } + //draw scale + if (logo.y_axis) draw_scale(ctx, metrics, logo.alphabet.get_ic(), raster); + ctx.save();//s5 + //translate across past the scale + if (logo.y_axis) { + ctx.translate(Math.round(metrics.y_label_height + metrics.y_label_spacer + + metrics.y_num_width + metrics.y_tic_width), Math.round(metrics.y_num_height / 2)); + } + //draw the trimming background + if (pspm.get_left_trim() > 0 || pspm.get_right_trim() > 0) { + var left_start = offset * logo.get_xlate_nsyms(); + var left_end = (offset + pspm.get_left_trim()) * logo.get_xlate_nsyms(); + var left_divider = true; + if (left_end < logo.get_xlate_start() || left_start > logo.get_xlate_end()) { + // no overlap + left_start = 0; + left_end = 0; + left_divider = false; + } else { + if (left_start < logo.get_xlate_start()) { + left_start = logo.get_xlate_start(); + } + if (left_end > logo.get_xlate_end()) { + left_end = logo.get_xlate_end(); + left_divider = false; + } + left_start -= logo.get_xlate_start(); + left_end -= logo.get_xlate_start(); + if (left_end < left_start) { + left_start = 0; + left_end = 0; + left_divider = false; + } + } + var right_end = (offset + pspm.get_motif_length()) * logo.get_xlate_nsyms(); + //var right_start = right_end - (pspm.get_left_trim() * logo.get_xlate_nsyms()); + var right_start = right_end - (pspm.get_right_trim() * logo.get_xlate_nsyms()); + var right_divider = true; + if (right_end < logo.get_xlate_start() || right_start > logo.get_xlate_end()) { + // no overlap + right_start = 0; + right_end = 0; + right_divider = false; + } else { + if (right_start < logo.get_xlate_start()) { + right_start = logo.get_xlate_start(); + right_divider = false; + } + if (right_end > logo.get_xlate_end()) { + right_end = logo.get_xlate_end(); + } + right_start -= logo.get_xlate_start(); + right_end -= logo.get_xlate_start(); + if (right_end < right_start) { + right_start = 0; + right_end = 0; + right_divider = false; + } + } + draw_trim_background(ctx, metrics, left_start, left_end, left_divider, right_start, right_end, right_divider); + } + //draw letters + var xlate_col; + for (xlate_col = logo.get_xlate_start(); xlate_col < logo.get_xlate_end(); xlate_col++) { + ctx.translate(metrics.stack_pad_left,0); + col_index = Math.floor(xlate_col / logo.get_xlate_nsyms()); + if (xlate_col % logo.get_xlate_nsyms() == 0) { + if (col_index >= offset && col_index < (offset + pspm.get_motif_length())) { + motif_position = col_index - offset; + draw_stack_num(ctx, metrics, motif_position, raster); + draw_stack(ctx, metrics, pspm.get_stack(motif_position, logo.alphabet, ssc), raster); + } + } else { + if (col_index >= offset && col_index < (offset + pspm.get_motif_length())) { + ctx.save();// s5.1 + ctx.translate(0, Math.round(metrics.stack_height)); + // TODO draw a dot or dash or something to indicate continuity of the motif + ctx.restore(); //s5.1 + } + } + ctx.translate(Math.round(metrics.stack_width), 0); + } + ctx.restore();//s5 + ////optionally draw name if this is the last row but isn't the only row + if (draw_name && (logo.get_rows() != 1 && pspm_i == (logo.get_rows()-1))) { + //translate vertically past the stack and axis's + ctx.translate(0, metrics.y_num_height/2 + metrics.stack_height + + Math.max(metrics.y_num_height/2, metrics.x_num_above + metrics.x_num_width + metrics.name_spacer)); + + ctx.save();//s6 + ctx.translate(metrics.summed_width/2, metrics.name_height); + ctx.font = metrics.name_font; + ctx.textAlign = "center"; + ctx.fillText(pspm.name, 0, 0); + ctx.restore();//s6 + ctx.translate(0, metrics.name_height); + } else { + //translate vertically past the stack and axis's + ctx.translate(0, metrics.y_num_height/2 + metrics.stack_height + + Math.max(metrics.y_num_height/2, metrics.x_num_above + metrics.x_num_width)); + } + //if not the last row then add middle padding + if (pspm_i != (logo.get_rows() -1)) { + ctx.translate(0, metrics.pad_middle); + } + } + ctx.restore();//s7 + if (logo.fine_text.length > 0) { + ctx.translate(metrics.summed_width - metrics.pad_right, metrics.summed_height - metrics.pad_bottom); + ctx.font = metrics.fine_txt_font; + ctx.textAlign = "right"; + ctx.fillText(logo.fine_text, 0,0); + } + ctx.restore();//s2 + ctx.restore();//s1 +} + +function create_canvas(c_width, c_height, c_id, c_title, c_display) { + "use strict"; + var canvas = document.createElement("canvas"); + //check for canvas support before attempting anything + if (!canvas.getContext) { + return null; + } + var ctx = canvas.getContext('2d'); + //check for html5 text drawing support + if (!supports_text(ctx)) { + return null; + } + //size the canvas + canvas.width = c_width; + canvas.height = c_height; + canvas.id = c_id; + canvas.title = c_title; + canvas.style.display = c_display; + return canvas; +} + +function logo_1(alphabet, fine_text, pspm) { + "use strict"; + var logo = new Logo(alphabet, fine_text); + logo.add_pspm(pspm); + return logo; +} + +function logo_2(alphabet, fine_text, target, query, query_offset) { + "use strict"; + var logo = new Logo(alphabet, fine_text); + if (query_offset < 0) { + logo.add_pspm(target, -query_offset); + logo.add_pspm(query); + } else { + logo.add_pspm(target); + logo.add_pspm(query, query_offset); + } + return logo; +} + +/* + * Specifies an alternate source for an image. + * If the image with the image_id specified has + * not loaded then a generated logo will be used + * to replace it. + * + * Note that the image must either have dimensions + * or a scale must be set. + */ +function alternate_logo(logo, image_id, scale) { + "use strict"; + var image = document.getElementById(image_id); + if (!image) { + alert("Can't find specified image id (" + image_id + ")"); + return; + } + //if the image has loaded then there is no reason to use the canvas + if (image_ok(image)) { + return; + } + //the image has failed to load so replace it with a canvas if we can. + var canvas = create_canvas(image.width, image.height, image_id, image.title, image.style.display); + if (canvas === null) { + return; + } + //draw the logo on the canvas + draw_logo_on_canvas(logo, canvas, null, scale); + //replace the image with the canvas + image.parentNode.replaceChild(canvas, image); +} + +/* + * Specifes that the element with the specified id + * should be replaced with a generated logo. + */ +function replace_logo(logo, replace_id, scale, title_txt, display_style) { + "use strict"; + var element = document.getElementById(replace_id); + if (!replace_id) { + alert("Can't find specified id (" + replace_id + ")"); + return; + } + //found the element! + var canvas = create_canvas(50, 120, replace_id, title_txt, display_style); + if (canvas === null) { + return; + } + //draw the logo on the canvas + draw_logo_on_canvas(logo, canvas, null, scale); + //replace the element with the canvas + element.parentNode.replaceChild(canvas, element); +} + +/* + * Fast string trimming implementation found at + * http://blog.stevenlevithan.com/archives/faster-trim-javascript + * + * Note that regex is good at removing leading space but + * bad at removing trailing space as it has to first go through + * the whole string. + */ +function trim (str) { + "use strict"; + var ws, i; + str = str.replace(/^\s\s*/, ''); + ws = /\s/; i = str.length; + while (ws.test(str.charAt(--i))); + return str.slice(0, i + 1); +} +</script> + <script> + +// PRIVATE GLOBAL (uhoh) +var _block_colour_lookup = {}; + +function block_colour(index) { + function hsl2rgb(hue, saturation, lightness) { + "use strict"; + function _hue(p, q, t) { + "use strict"; + if (t < 0) t += 1; + else if (t > 1) t -= 1; + if (t < (1.0 / 6.0)) { + return p + ((q - p) * 6.0 * t); + } else if (t < 0.5) { + return q; + } else if (t < (2.0 / 3.0)) { + return p + ((q - p) * ((2.0 / 3.0) - t) * 6.0); + } else { + return p; + } + } + function _pad_hex(value) { + var hex = Math.round(value * 255).toString(16); + if (hex.length < 2) hex = "0" + hex; + return hex; + } + var r, g, b, p, q; + if (saturation == 0) { + // achromatic (grayscale) + r = lightness; + g = lightness; + b = lightness; + } else { + if (lightness < 0.5) { + q = lightness * (1 + saturation); + } else { + q = lightness + saturation - (lightness * saturation); + } + p = (2 * lightness) - q; + r = _hue(p, q, hue + (1.0 / 3.0)); + g = _hue(p, q, hue); + b = _hue(p, q, hue - (1.0 / 3.0)); + } + return "#" + _pad_hex(r) + _pad_hex(g) + _pad_hex(b); + } + if (typeof index !== "number" || index % 1 !== 0 || index < 0) return "#000000"; + // check for override + if (_block_colour_lookup[index] == null) { + var start = 0; //red + var sat = 100; + var light = 50; + var divisions = 1 << Math.ceil(Math.log(index + 1) / Math.LN2); + hue = start + (360 / divisions) * ((index - (divisions >> 1)) * 2 + 1); + // colour input fields only support values in the form #RRGGBB + _block_colour_lookup[index] = hsl2rgb(hue / 360, sat / 100, light / 100); + } + return _block_colour_lookup[index]; +} + +function set_block_colour(index, new_colour) { + _block_colour_lookup[index] = new_colour; + var blocks = document.querySelectorAll("div.block_motif[data-colour-index=\"" + index + "\"]"); + var i; + for (i = 0; i < blocks.length; i++) { + blocks[i].style.backgroundColor = new_colour; + } + var swatches = document.querySelectorAll("div.legend_swatch[data-colour-index=\"" + index + "\"]"); + var picker; + for (i = 0; i < swatches.length; i++) { + swatches[i].style.backgroundColor = new_colour; + picker = swatches[i].querySelector("input[type=\"color\"]"); + if (picker != null) picker.value = new_colour; + } +} + +function make_block_legend_entry(motif_name, motif_colour_index) { + if (typeof make_block_legend_entry.has_colour_picker !== "boolean") { + // test if colour picker is supported, based off Modernizer + // see http://stackoverflow.com/a/7787648/66387 + make_block_legend_entry.has_colour_picker = (function() { + var doc_ele = document.documentElement; + // We first check to see if the type we give it sticks.. + var input_ele = document.createElement('input'); + input_ele.setAttribute('type', 'color'); + var value_ok = input_ele.type !== 'text'; + if (value_ok) { + // If the type does, we feed it a textual value, which shouldn't be valid. + // If the value doesn't stick, we know there's input sanitization which infers a custom UI + var smile = ':)'; + input_ele.value = smile; + input_ele.style.cssText = 'position:absolute;visibility:hidden;'; + // chuck into DOM and force reflow for Opera bug in 11.00 + // github.com/Modernizr/Modernizr/issues#issue/159 + doc_ele.appendChild(input_ele); + doc_ele.offsetWidth; + value_ok = input_ele.value != smile; + doc_ele.removeChild(input_ele); + } + return value_ok; + })(); + } + var entry = document.createElement("div"); + entry.className = "legend_entry"; + var swatch; + swatch = document.createElement("div"); + swatch.className = "legend_swatch"; + swatch.setAttribute("data-colour-index", motif_colour_index); + swatch.style.backgroundColor = block_colour(motif_colour_index); + if (make_block_legend_entry.has_colour_picker) { + var picker = document.createElement("input"); + picker.type = "color"; + picker.value = block_colour(motif_colour_index); + picker.addEventListener("change", function(e) { + set_block_colour(motif_colour_index, picker.value); + }, false); + swatch.addEventListener("click", function(e) { + picker.click(); + }, false); + swatch.appendChild(picker); + } + entry.appendChild(swatch); + var name = document.createElement("div"); + name.className = "legend_text"; + name.appendChild(document.createTextNode(motif_name)); + entry.appendChild(name); + return entry; +} + +function make_block_ruler(max_len) { + var container = document.createElement("div"); + container.className = "block_container"; + var step; + if (max_len < 50) { + step = 1; + } else if (max_len < 100) { + step = 2; + } else if (max_len < 200) { + step = 4; + } else if (max_len < 500) { + step = 10; + } else if (max_len < 1000) { + step = 20; + } else if (max_len < 2000) { + step = 40; + } else if (max_len < 5000) { + step = 100; + } else if (max_len < 10000) { + step = 200; + } else if (max_len < 20000) { + step = 400; + } else { + step = Math.floor(max_len / 20000) * 400; + } + var peroid; + if (max_len < 10) { + peroid = 1; + } else if (max_len < 20) { + peroid = 2; + } else { + peroid = 5; + } + var i, cycle, offset, tic, label; + for (i = 0, cycle = 0; i < max_len; i += step, cycle = (cycle + 1) % peroid) { + offset = "" + ((i / max_len) * 100) + "%"; + tic = document.createElement("div"); + tic.style.left = offset; + tic.className = (cycle == 0 ? "tic_major" : "tic_minor"); + container.appendChild(tic); + if (cycle == 0) { + label = document.createElement("div"); + label.className = "tic_label"; + label.style.left = offset; + label.appendChild(document.createTextNode(i)); + container.appendChild(label); + } + } + return container; +} + +function _calculate_block_needle_drag_pos(e, data) { + var mouse; + e = e || window.event; + if (e.pageX || ev.pageY) { + mouse = {"x": e.pageX, "y": e.pageY}; + } else { + mouse = { + x:e.clientX + document.body.scrollLeft - document.body.clientLeft, + y:e.clientY + document.body.scrollTop - document.body.clientTop + }; + } + var cont = data.container; + var dragable_length = cont.clientWidth - + (cont.style.paddingLeft ? cont.style.paddingLeft : 0) - + (cont.style.paddingRight ? cont.style.paddingRight : 0); + //I believe that the offset parent is the body + //otherwise I would need to make this recursive + //maybe clientLeft would work, but the explanation of + //it is hard to understand and it apparently doesn't work + //in firefox 2. + var diff = mouse.x - cont.offsetLeft; + if (diff < 0) diff = 0; + if (diff > dragable_length) diff = dragable_length; + var pos = Math.round(diff / dragable_length * data.max); + if (pos > data.len) pos = data.len; + return pos; +} + +function _update_block_needle_drag(e, data, done) { + "use strict"; + var pos = _calculate_block_needle_drag_pos(e, data); + // read the needle positions + var left = parseInt(data.llabel.textContent, 10) - data.off - 1; + var right = parseInt(data.rlabel.textContent, 10) - data.off; + // validate needle positions + if (left >= data.len) left = data.len - 1; + if (left < 0) left = 0; + if (right > data.len) right = data.len; + if (right <= left) right = left + 1; + // calculate the new needle positions + if (data.moveboth) { + var size = right - left; + if (data.isleft) { + if ((pos + size) > data.len) pos = data.len - size; + left = pos; + right = pos + size; + } else { + if ((pos - size) < 0) pos = size; + left = pos - size; + right = pos; + } + } else { + if (data.isleft) { + if (pos >= right) pos = right - 1; + left = pos; + } else { + if (pos <= left) pos = left + 1; + right = pos; + } + } + // update the needle positions + data.lneedle.style.left = "" + (left / data.max * 100) + "%"; + data.llabel.textContent = "" + (left + data.off + 1); + data.rneedle.style.left = "" + (right / data.max * 100) + "%"; + data.rlabel.textContent = "" + (right + data.off); + data.handler(left, right, done); +} + +function _make_block_needle_drag_start_handler(isleft, data) { + return function (e) { + data.isleft = isleft; + data.moveboth = !(e.shiftKey); + document.addEventListener("mousemove", data.drag_during, false); + document.addEventListener("mouseup", data.drag_end, false); + }; +} + +function _make_block_needle_drag_end_handler(data) { + return function (e) { + document.removeEventListener("mousemove", data.drag_during, false); + document.removeEventListener("mouseup", data.drag_end, false); + _update_block_needle_drag(e, data, true); + }; +} + +function _make_block_needle_drag_during_handler(data) { + return function (e) { + _update_block_needle_drag(e, data, false); + }; +} + +// private function used by make_block_container +function _make_block_needle(isleft, value, data) { + var vbar = document.createElement('div'); + vbar.className = "block_needle " + (isleft ? "left" : "right"); + vbar.style.left = "" + (value / data.max * 100)+ "%"; + var label = document.createElement('div'); + label.className = "block_handle " + (isleft ? "left" : "right"); + // The needles sit between the sequence positions, so the left one sits at the + // start and the right at the end. This is why 1 is added to the displayed + // value for a left handle as the user doesn't need to know about this detail + label.textContent = "" + (isleft ? value + data.off + 1 : value + data.off); + label.unselectable = "on"; // so IE and Opera don't select the text, others are done in css + label.title = "Drag to move the displayed range. Hold shift and drag to change " + (isleft ? "lower" : "upper") + " bound of the range."; + vbar.appendChild(label); + if (isleft) { + data.lneedle = vbar; + data.llabel = label; + } else { + data.rneedle = vbar; + data.rlabel = label; + } + label.addEventListener("mousedown", _make_block_needle_drag_start_handler(isleft, data), false); + return vbar; +} + +function make_block_container(is_stranded, has_both_strands, max_len, show_len, offset, range_handler) { + offset = (offset != null ? offset : 0); + // make the container for the block diagram + var container = document.createElement("div"); + container.className = "block_container"; + container.setAttribute("data-max", max_len); + container.setAttribute("data-off", offset); + if (is_stranded) { + var plus = document.createElement("div"); + plus.appendChild(document.createTextNode("+")); + plus.className = "block_plus_sym"; + container.appendChild(plus); + if (has_both_strands) { + var minus = document.createElement("div"); + minus.appendChild(document.createTextNode("-")); + minus.className = "block_minus_sym"; + container.appendChild(minus); + } + } + var rule = document.createElement("div"); + rule.className = "block_rule"; + rule.style.width = ((show_len / max_len) * 100) + "%"; + container.appendChild(rule); + if (range_handler != null) { + var range_data = { + "max": max_len, + "len": show_len, + "off": offset, + "handler": range_handler, + "container": container, + "lneedle": null, "llabel": null, + "rneedle": null, "rlabel": null, + "isleft": false, "moveboth" : false + }; + range_data.drag_during = _make_block_needle_drag_during_handler(range_data); + range_data.drag_end = _make_block_needle_drag_end_handler(range_data); + container.appendChild(_make_block_needle(false, 1, range_data)); // add right first so z-index works + container.appendChild(_make_block_needle(true, 0, range_data)); + } + return container; +} + +function make_block_label(container, max_len, pos, length, message) { + "use strict"; + var label = document.createElement("div"); + label.className = "block_label"; + label.style.left = (((pos + (length / 2)) / max_len) * 100) + "%"; + label.appendChild(document.createTextNode(message)); + container.appendChild(label); +} + +function make_block(container, max_len, + site_pos, site_len, site_pvalue, site_rc, site_colour_index, site_secondary) { + "use strict"; + var block_height, block, block_region1, block_region2; + var max_block_height = 12; + var max_pvalue = 1e-10; + // calculate the height of the block + block_height = (site_pvalue < max_pvalue ? max_block_height : + (Math.log(site_pvalue) / Math.log(max_pvalue)) * max_block_height); + if (block_height < 1) block_height = 1; + // create a block to represent the motif + block = document.createElement("div"); + block.className = "block_motif" + (site_secondary ? " scanned_site" : "") + (site_rc ? " bottom" : " top"); + block.style.left = ((site_pos / max_len) * 100) + "%"; + block.style.top = (!site_rc ? max_block_height - block_height : + max_block_height + 1) + "px"; + block.style.width = ((site_len / max_len) * 100) + "%"; + block.style.height = block_height + "px"; + block.style.backgroundColor = block_colour(site_colour_index); + block.setAttribute("data-colour-index", site_colour_index); + // add to container + container.appendChild(block); + var activator = function (e) { + toggle_class(block, "active", true); + var new_e = new e.constructor(e.type, e); + block.dispatchEvent(new_e); + }; + var deactivator = function (e) { + toggle_class(block, "active", false); + var new_e = new e.constructor(e.type, e); + block.dispatchEvent(new_e); + } + // create a larger region to detect mouseover for the block + block_region1 = document.createElement("div"); + block_region1.className = "block_region top" + + (site_secondary ? " scanned_site" : "") + (site_rc ? "" : " main"); + block_region1.style.left = block.style.left; + block_region1.style.width = block.style.width; + block_region1.addEventListener('mouseover', activator, false); + block_region1.addEventListener('mouseout', deactivator, false); + container.appendChild(block_region1); + block_region2 = document.createElement("div"); + block_region2.className = "block_region bottom" + + (site_secondary ? " scanned_site" : "") + (site_rc ? " main" : ""); + block_region2.style.left = block.style.left; + block_region2.style.width = block.style.width; + block_region2.addEventListener('mouseover', activator, false); + block_region2.addEventListener('mouseout', deactivator, false); + container.appendChild(block_region2); + return block; +} + +function set_block_needle_positions(containingNode, start, end) { + var container, lneedle, llabel, rneedle, rlabel, max, off, left, right; + container = (/\bblock_container\b/.test(containingNode.className) ? containingNode : containingNode.querySelector(".block_container")); + max = parseInt(container.getAttribute("data-max"), 10); + off = parseInt(container.getAttribute("data-off"), 10); + left = start - off; + right = end - off; + lneedle = containingNode.querySelector(".block_needle.left"); + llabel = lneedle.querySelector(".block_handle.left"); + rneedle = containingNode.querySelector(".block_needle.right"); + rlabel = rneedle.querySelector(".block_handle.right"); + // update the needle positions + lneedle.style.left = "" + (left / max * 100) + "%"; + llabel.textContent = "" + (left + off + 1); + rneedle.style.left = "" + (right / max * 100) + "%"; + rlabel.textContent = "" + (right + off); +} + +function get_block_needle_positions(containingNode) { + var container, llabel, rlabel, max, off, left, right; + container = (/\bblock_container\b/.test(containingNode.className) ? containingNode : containingNode.querySelector(".block_container")); + max = parseInt(container.getAttribute("data-max"), 10); + off = parseInt(container.getAttribute("data-off"), 10); + llabel = containingNode.querySelector(".block_needle.left > .block_handle.left"); + rlabel = containingNode.querySelector(".block_needle.right > .block_handle.right"); + left = parseInt(llabel.textContent, 10) - off - 1; + right = parseInt(rlabel.textContent, 10) - off; + return {"start": left + off, "end": right + off}; +} +</script> + <script> +function make_alpha_bg_table(alph, freqs) { + function colour_symbol(index) { + var span = document.createElement("span"); + span.appendChild(document.createTextNode(alph.get_symbol(index))); + span.style.color = alph.get_colour(index); + span.className = "alpha_symbol"; + return span; + } + var table, thead, tbody, row, th, span, i; + // create table + table = document.createElement("table"); + table.className = "alpha_bg_table"; + // create header + thead = document.createElement("thead"); + table.appendChild(thead); + row = thead.insertRow(thead.rows.length); + if (alph.has_complement()) { + add_text_header_cell(row, "Name", "pop_alph_name"); + if (freqs != null) add_text_header_cell(row, "Freq.", "pop_alph_freq"); + if (alph.has_bg()) add_text_header_cell(row, "Bg.", "pop_alph_bg"); + add_text_header_cell(row, ""); + add_text_header_cell(row, ""); + add_text_header_cell(row, ""); + if (alph.has_bg()) add_text_header_cell(row, "Bg.", "pop_alph_bg"); + if (freqs != null) add_text_header_cell(row, "Freq.", "pop_alph_freq"); + add_text_header_cell(row, "Name", "pop_alph_name"); + } else { + add_text_header_cell(row, ""); + add_text_header_cell(row, "Name", "pop_alph_name"); + if (freqs != null) add_text_header_cell(row, "Freq.", "pop_alph_freq"); + if (alph.has_bg()) add_text_header_cell(row, "Bg.", "pop_alph_bg"); + } + // add alphabet entries + tbody = document.createElement("tbody"); + table.appendChild(tbody); + if (alph.has_complement()) { + for (i = 0; i < alph.get_size_core(); i++) { + var c = alph.get_complement(i); + if (i > c) continue; + row = tbody.insertRow(tbody.rows.length); + add_text_cell(row, alph.get_name(i)); + if (freqs != null) add_text_cell(row, "" + freqs[i].toFixed(3)); + if (alph.has_bg()) add_text_cell(row, "" + alph.get_bg_freq(i).toFixed(3)); + add_cell(row, colour_symbol(i)); + add_text_cell(row, "~"); + add_cell(row, colour_symbol(c)); + if (alph.has_bg()) add_text_cell(row, "" + alph.get_bg_freq(c).toFixed(3)); + if (freqs != null) add_text_cell(row, "" + freqs[c].toFixed(3)); + add_text_cell(row, alph.get_name(c)); + } + } else { + for (i = 0; i < alph.get_size_core(); i++) { + row = tbody.insertRow(tbody.rows.length); + add_cell(row, colour_symbol(i)); + add_text_cell(row, alph.get_name(i)); + if (freqs != null) add_text_cell(row, "" + freqs[i].toFixed(3)); + if (alph.has_bg()) add_text_cell(row, "" + alph.get_bg_freq(i).toFixed(3)); + } + } + return table; +} + +</script> + <script> +var current_motif = 0; +var meme_alphabet = new Alphabet(data.alphabet, data.background.freqs); + +var DelayLogoTask = function(logo, canvas) { + this.logo = logo; + this.canvas = canvas; +}; + +DelayLogoTask.prototype.run = function () { + draw_logo_on_canvas(this.logo, this.canvas, false); +}; + +function motif_pspm(index) { + var motif, pwm, psm, name, ltrim, rtrim, nsites, evalue; + // get motif + motif = data["motifs"][index]; + // get motif paramters + pwm = motif["pwm"]; + psm = motif["psm"]; + name = "" + (index + 1); ltrim = 0; rtrim = 0; + nsites = motif["nsites"]; evalue = motif["evalue"]; + // make pspm + return new Pspm(pwm, name, ltrim, rtrim, nsites, evalue, psm); +} + +function motif_count_matrix(index) { + return motif_pspm(index).as_count_matrix(); +} + +function motif_prob_matrix(index) { + return motif_pspm(index).as_probability_matrix(); +} + +function motif_minimal_meme(index) { + return motif_pspm(index).as_meme({ + "with_header": true, + "with_pspm": true, + "with_pssm": true, + "version": data["version"], + "alphabet": meme_alphabet, + "strands": (meme_alphabet.has_complement() && data.options.revcomp ? 2 : 1) + }); +} + +function motif_fasta(index) { + "use strict"; + var motif, sites, site, seq, sequences, sequence, i, num, counter, out; + counter = {}; + sequences = data["sequence_db"]["sequences"]; + motif = data["motifs"][index]; + sites = motif["sites"]; + out = ""; + for (i = 0; i < sites.length; i++) { + site = sites[i]; + seq = site["seq"]; + sequence = sequences[seq]; + counter[seq] = (num = counter[seq]) ? (++num) : (num = 1); // inc counter + if (i !== 0) {out += "\n";} + out += ">" + sequence["name"] + "_site_" + num + " offset= " + site["pos"] + + (site["rc"] ? " RC\n" : "\n"); + out += site["match"]; + } + return out; +} + +function motif_raw(index) { + "use strict"; + var sites, i, out; + sites = data["motifs"][index]["sites"]; + out = ""; + for (i = 0; i < sites.length; i++) { + if (i !== 0) {out += "\n";} + out += sites[i]["match"]; + } + return out; +} + +function clone_template(template) { + "use strict"; + var node, help_btns, i, button; + node = $(template).cloneNode(true); + toggle_class(node, "template", false); + node.id = ""; + help_btns = node.querySelectorAll(".help"); + for (i = 0; i < help_btns.length; i++) { + button = help_btns[i]; + if (button.hasAttribute("data-topic")) { + button.tabIndex = "0"; + button.addEventListener("click", __toggle_help, false); + button.addEventListener("keydown", __toggle_help, false); + } + } + return node; +} + +function set_tvar(template, tvar, value) { + var node; + node = find_child(template, tvar); + if (node === null) { + throw new Error("Template does not contain variable " + tvar); + } + node.innerHTML = ""; + if (typeof value !== "object") { + node.appendChild(document.createTextNode(value)); + } else { + node.appendChild(value); + } +} + +function make_logo(alphabet, pspm, rc, offset, className) { + if (rc) pspm = pspm.copy().reverse_complement(alphabet); + var logo = new Logo(alphabet, ""); + logo.add_pspm(pspm, offset); + var canvas = document.createElement('canvas'); + canvas.height = 50; + canvas.width = 0; + canvas.className = className; + size_logo_on_canvas(logo, canvas, false); + add_draw_task(canvas, new DelayLogoTask(logo, canvas)); + return canvas; +} + +function make_small_logo(alphabet, pspm, options) { + if (typeof options === "undefined") options = {}; + if (options.rc) pspm = pspm.copy().reverse_complement(alphabet); + var logo = new Logo(alphabet, {x_axis: false, y_axis: false}); + logo.add_pspm(pspm, (typeof options.offset === "number" ? options.offset : 0)); + var canvas = document.createElement('canvas'); + if (typeof options.className === "string") canvas.className = options.className; + if (typeof options.width === "number" && options.width > 0) { + canvas.height = 0; + canvas.width = options.width; + draw_logo_on_canvas(logo, canvas, false); + } else { + draw_logo_on_canvas(logo, canvas, false, 1/3); + } + return canvas; +} + +function make_large_logo(alphabet, pspm, rc, offset, className) { + if (rc) pspm = pspm.copy().reverse_complement(alphabet); + var logo = new Logo(alphabet, ""); + logo.add_pspm(pspm, offset); + var canvas = document.createElement('canvas'); + canvas.height = 200; + canvas.width = 0; + canvas.className = className; + size_logo_on_canvas(logo, canvas, false); + add_draw_task(canvas, new DelayLogoTask(logo, canvas)); + return canvas; +} + +function make_sym_btn(symbol, title, action) { + var box; + box = document.createElement("div"); + box.tabIndex = 0; + box.className = "sym_btn"; + box.appendChild(document.createTextNode(symbol)); + box.title = title; + box.addEventListener('click', action, false); + box.addEventListener('keydown', action, false); + return box; +} + +function make_seq(alphabet, seq) { + var i, j, letter, lbox, sbox; + sbox = document.createElement("span"); + for (i = 0; i < seq.length; i = j) { + letter = seq.charAt(i); + for (j = i+1; j < seq.length; j++) { + if (seq.charAt(j) !== letter) { + break; + } + } + lbox = document.createElement("span"); + lbox.style.color = alphabet.get_colour(alphabet.get_index(letter)); + lbox.appendChild(document.createTextNode(seq.substring(i, j))); + sbox.appendChild(lbox); + } + return sbox; +} + +// +// make_pv_text +// +// Returns the string p-value, with the p italicised. +/// +function make_pv_text() { + var pv_text = document.createElement("span"); + var pv_italic_text = document.createElement("span"); + pv_italic_text.appendChild(document.createTextNode("p")); + pv_italic_text.style.fontStyle = "italic"; + pv_text.appendChild(pv_italic_text); + pv_text.appendChild(document.createTextNode("-value")); + return pv_text; +} + +function append_site_entries(tbody, motif, site_index, count) { + "use strict"; + var i, end; + var sites, site, sequences, sequence; + var rbody; + if (typeof count !== "number") { + count = 20; + } + sequences = data["sequence_db"]["sequences"]; + sites = motif["sites"]; + end = Math.min(site_index + count, sites.length); + for (i = site_index; i < end; i++) { + site = sites[i]; + sequence = sequences[site["seq"]]; + + rbody = tbody.insertRow(tbody.rows.length); + add_text_cell(rbody, "" + (site["seq"] + 1) + ".", "site_num"); + add_text_cell(rbody, sequence["name"], "site_name"); + add_text_cell(rbody, site["rc"] ? "-" : "+", "site_strand"); + add_text_cell(rbody, site["pos"] + 1, "site_start"); + add_text_cell(rbody, site["pvalue"].toExponential(2), "site_pvalue"); + add_text_cell(rbody, site["lflank"], "site lflank"); + add_cell(rbody, make_seq(meme_alphabet, site["match"]), "site match"); + add_text_cell(rbody, site["rflank"], "site rflank"); + } + return i; +} + +function make_site_entries() { + "use strict"; + var region; + region = this; + if (region.data_site_index >= region.data_motif["sites"].length) { + // all sites created + region.removeEventListener('scroll', make_site_entries, false); + return; + } + // if there's still 100 pixels to scroll than don't do anything yet + if (region.scrollHeight - (region.scrollTop + region.offsetHeight) > 100) { + return; + } + + region.data_site_index = append_site_entries( + find_child(region, "sites_tbl").tBodies[0], + region.data_motif, region.data_site_index, 20 + ); +} + +function make_sites(motif) { + "use strict"; + function add_site_header(row, title, nopad, help_topic, tag_class) { + var div, divcp, th; + th = document.createElement("th"); + div = document.createElement("div"); + div.className = "sites_th_inner"; + if (typeof title !== "object") { + title = document.createTextNode("" + title); + } + div.appendChild(title); + if (help_topic) { + div.appendChild(document.createTextNode("\xA0")); + div.appendChild(help_button(help_topic)); + } + divcp = div.cloneNode(true); + divcp.className = "sites_th_hidden"; + th.appendChild(div); + th.appendChild(divcp); + if (nopad) { + th.className = "nopad"; + } + if (tag_class) { + th.className += " " + tag_class; + } + row.appendChild(th); + } + var outer_tbl, inner_tbl, tbl, thead, tbody, rhead; + + outer_tbl = document.createElement("div"); + outer_tbl.className = "sites_outer"; + + inner_tbl = document.createElement("div"); + inner_tbl.className = "sites_inner"; + outer_tbl.appendChild(inner_tbl); + + tbl = document.createElement("table"); + tbl.className = "sites_tbl"; + inner_tbl.appendChild(tbl); + + thead = document.createElement("thead"); + tbl.appendChild(thead); + tbody = document.createElement("tbody"); + tbl.appendChild(tbody); + + rhead = thead.insertRow(thead.rows.length); + add_site_header(rhead, "", true); + add_site_header(rhead, "Name", false, "pop_seq_name"); + add_site_header(rhead, "Strand", false, "pop_site_strand", "site_strand_title"); + add_site_header(rhead, "Start", false, "pop_site_start"); + add_site_header(rhead, make_pv_text(), false, "pop_site_pvalue"); + add_site_header(rhead, "", false); + add_site_header(rhead, "Sites", true, "pop_site_match"); + add_site_header(rhead, "", false); + + inner_tbl.data_motif = motif; + inner_tbl.data_site_index = append_site_entries(tbody, motif, 0, 20); + if (inner_tbl.data_site_index < motif["sites"].length) { + inner_tbl.addEventListener('scroll', make_site_entries, false); + } + return outer_tbl; +} + +function make_motif_table_entry(row, alphabet, ordinal, motif, colw) { + "use strict"; + function ev_sig(evalue_str) { + "use strict"; + var ev_re, match, sig, exp, num; + ev_re = /^(.*)e(.*)$/; + if (match = ev_re.exec(evalue_str)) { + sig = parseFloat(match[1]); + exp = parseInt(match[2]); + if (exp >= 0) { + return false; + } else if (exp <= -3) { + return true; + } else { + return sig * Math.pow(10, exp) <= 0.05; + } + } + return true; + } + function make_preview(alphabet, motif) { + "use strict"; + var pspm, preview, preview_rc; + var box, btn_box, logo_box, btn_plus, btn_minus; + if (motif["preview_logo"]) { + preview = motif["preview_logo"]; + preview_rc = motif["preview_logo_rc"]; + } else { + pspm = new Pspm(motif["pwm"]); + preview = make_logo(alphabet, pspm); + motif["preview_logo"] = preview; + if (alphabet.has_complement()) { + preview_rc = make_logo(alphabet, pspm, true, 0, "logo_rc"); + motif["preview_logo_rc"] = preview_rc; + } + } + if (preview_rc) { + btn_plus = document.createElement("div"); + btn_plus.appendChild(document.createTextNode("+")); + btn_plus.className = "preview_btn plus"; + btn_plus.tabIndex = "0"; + btn_plus.addEventListener("click", action_btn_rc, false); + btn_plus.addEventListener("keydown", action_btn_rc, false); + btn_minus = document.createElement("div"); + btn_minus.appendChild(document.createTextNode("-")); + btn_minus.className = "preview_btn minus"; + btn_minus.tabIndex = "0"; + btn_minus.addEventListener("click", action_btn_rc, false); + btn_minus.addEventListener("keydown", action_btn_rc, false); + btn_box = document.createElement("div"); + btn_box.className = "preview_btn_box"; + btn_box.appendChild(btn_plus); + btn_box.appendChild(btn_minus); + } + logo_box = document.createElement("div"); + logo_box.className = "preview_logo_box"; + logo_box.appendChild(preview); + if (preview_rc) logo_box.appendChild(preview_rc); + box = document.createElement("div"); + box.className = "preview_box"; + if (preview_rc) box.appendChild(btn_box); + box.appendChild(logo_box); + if (preview_rc) { + if (motif["rc"]) { + btn_minus.className += " active"; + logo_box.className += " show_rc_logo"; + } else { + btn_plus.className += " active"; + } + } + return box; + } + var pspm, preview, preview_rc, c; + row.data_motif = motif; + row.data_ordinal = ordinal; + if (!ev_sig(motif["evalue"])) { + row.style.opacity = 0.4; + } + add_text_cell(row, "" + ordinal + ".", "motif_ordinal"); + add_cell(row, make_preview(alphabet, motif), "motif_logo"); + add_text_cell(row, motif["evalue"], "motif_evalue"); + add_text_cell(row, motif["nsites"], "motif_nsites"); + add_text_cell(row, motif["len"], "motif_width"); + add_cell(row, make_sym_btn("\u21A7", "Show more information.", + action_show_more), "motif_more"); + add_cell(row, + make_sym_btn("\u21E2", + "Submit the motif to another MEME Suite program or download it.", + action_show_outpop), + "motif_submit"); + if (colw) { + for (c = 0; c < row.cells.length; c++) { + row.cells[c].style.minWidth = colw[c] + "px"; + } + } +} + +function make_motifs_table(alphabet, start_ordinal, motifs, colw, stop_reason) { + var i, j; + var tbl, thead, tbody, tfoot, row, preview; + var motif, pspm; + + tbl = document.createElement("table"); + + thead = document.createElement("thead"); + tbl.appendChild(thead); + tbody = document.createElement("tbody"); + tbl.appendChild(tbody); + tfoot = document.createElement("tfoot"); + tbl.appendChild(tfoot); + + row = thead.insertRow(thead.rows.length); + add_text_header_cell(row, "", "", "motif_ordinal"); + add_text_header_cell(row, "Logo", "", "motif_logo"); + add_text_header_cell(row, "E-value", "pop_ev", "motif_evalue"); + add_text_header_cell(row, "Sites", "pop_sites", "motif_nsites"); + add_text_header_cell(row, "Width", "pop_width", "motif_width"); + add_text_header_cell(row, "More", "pop_more", "motif_more"); + add_text_header_cell(row, "Submit/Download", "pop_submit_dl", "motif_submit"); + + for (i = 0; i < motifs.length; i++) { + row = tbody.insertRow(tbody.rows.length); + make_motif_table_entry(row, alphabet, start_ordinal + i, motifs[i], colw); + } + + row = tfoot.insertRow(tfoot.rows.length); + add_text_header_cell(row, stop_reason, "", "stop_reason", "", 6); + + return tbl; +} + +function make_expanded_motif(alphabet, ordinal, motif, less_x, submit_x) { + "use strict"; + var box, pspm, logo_box, large_logo, large_logo_rc, tab_logo, tab_logo_rc; + var btn, offset, norc; + + box = clone_template("tmpl_motif_expanded"); + box.data_motif = motif; + box.data_ordinal = ordinal; + + pspm = new Pspm(motif["pwm"]); + if (typeof motif["rc"] !== "boolean") { + motif["rc"] = false; + } + if (motif["large_logo"]) { + large_logo = motif["large_logo"]; + large_logo_rc = motif["large_logo_rc"]; + } else { + large_logo = make_large_logo(alphabet, pspm, false, 0); + motif["large_logo"] = large_logo; + if (alphabet.has_complement()) { + large_logo_rc = make_large_logo(alphabet, pspm, true, 0, "logo_rc"); + motif["large_logo_rc"] = large_logo_rc; + } + } + norc = (large_logo_rc == null); + toggle_class(box, "norc", norc); + + logo_box = find_child(box, "tvar_logo"); + logo_box.appendChild(large_logo); + if (large_logo_rc) logo_box.appendChild(large_logo_rc); + toggle_class(logo_box, "show_rc_logo", motif["rc"]); + + tab_logo = find_child(box, "tvar_tab"); + tab_logo_rc = find_child(box, "tvar_tab_rc"); + + toggle_class(tab_logo, "activeTab", !motif["rc"]); + toggle_class(tab_logo_rc, "activeTab", motif["rc"]); + + tab_logo.addEventListener('click', action_rc_tab, false); + tab_logo.addEventListener('keydown', action_rc_tab, false); + tab_logo_rc.addEventListener('click', action_rc_tab, false); + tab_logo_rc.addEventListener('keydown', action_rc_tab, false); + + set_tvar(box, "tvar_ordinal", ordinal); + set_tvar(box, "tvar_evalue", motif["evalue"]); + set_tvar(box, "tvar_width", motif["len"]); + set_tvar(box, "tvar_site_count", motif["nsites"]); + set_tvar(box, "tvar_llr", motif["llr"]); + set_tvar(box, "tvar_ic", motif["ic"]); + set_tvar(box, "tvar_re", motif["re"]); + set_tvar(box, "tvar_bt", motif["bt"]); + set_tvar(box, "tvar_sites", make_sites(motif)); + + offset = 32; // 1* 5px padding + 2 * 10px padding + 2 * 2px border + 3px ?? + + btn = find_child(box, "tvar_less"); + btn.style.left = (less_x - offset) + "px"; + btn.addEventListener('click', action_show_less, false); + btn.addEventListener('keydown', action_show_less, false); + btn = find_child(box, "tvar_submit"); + btn.style.left = (submit_x - offset) + "px"; + btn.addEventListener('click', action_show_outpop, false); + btn.addEventListener('keydown', action_show_outpop, false); + return box; +} + + +// +// +/// +function make_motifs() { + "use strict"; + function pixel_value(str_in) { + "use strict"; + var px_re, match; + px_re = /^(\d+)px$/; + if (match = px_re.exec(str_in)) { + return parseInt(match[1], 10); + } + return 0; + } + var container, tbl; + var colw, r, row, c, cell, cell_style, pad_left, pad_right; + + // make the motifs table + container = $("motifs"); + container.innerHTML = ""; // clear content + + tbl = make_motifs_table(meme_alphabet, 1, data["motifs"], colw, data["stop_reason"]); + container.appendChild(tbl); + + // measure table column widths + colw = []; + row = tbl.tBodies[0].rows[0]; + for (c = 0; c < row.cells.length; c++) { + var padLeft, padRight; + cell = row.cells[c]; + cell_style = window.getComputedStyle(cell, null); + pad_left = pixel_value(cell_style.getPropertyValue("padding-left")); + pad_right = pixel_value(cell_style.getPropertyValue("padding-right")); + colw[c] = cell.clientWidth - pad_left - pad_right; + if (typeof colw[c] !== "number" || colw[c] < 0) { + colw[c] = 1; + } + } + + // set minimum table column widths on each row so later when we remove rows it still aligns + for (r = 0; r < tbl.tBodies[0].rows.length; r++) { + row = tbl.tBodies[0].rows[r]; + for (c = 0; c < row.cells.length; c++) { + row.cells[c].style.minWidth = colw[c] + "px"; + } + } + + // store the table column widths so we can create rows latter with the same minimums + container.data_colw = colw; + + // calculate the x offset for the buttons + row = tbl.tBodies[0].rows[0]; + container.data_more_x = coords(find_child(find_child(row, "motif_more"), "sym_btn"))[0]; + container.data_submit_x = coords(find_child(find_child(row, "motif_submit"), "sym_btn"))[0]; + + draw_on_screen(); +} + +function make_meme_block(container, max_seq_len, is_scan, site) { + "use strict"; + var motif = data.motifs[site.motif]; + var block = make_block(container, max_seq_len, site.pos, motif.len, + site.pvalue, site.rc, site.motif, is_scan); + var handler = (is_scan ? + make_scan_popup(site, motif, block) : + make_block_popup(site, motif, block)); + block.addEventListener("mouseover", handler, false); + block.addEventListener("mouseout", handler, false); +} + +function append_blocks_entries(tbody, seq_index, count) { + "use strict"; + var i, end, j; + var max_pvalue, max_block_height, max_seq_len, sequences; + var sequence, sites, scans, scan; + var container, plus, minus, rule, row; + // define some constants + max_seq_len = data.sequence_db.max_length; + // determine how many to load + end = Math.min(seq_index + count, data.sequence_db.sequences.length); + for (i = seq_index; i < end; i++) { + // get the sequence + sequence = data.sequence_db.sequences[i]; + // make the containers for the block diagram + container = make_block_container(meme_alphabet.has_complement(), + data.options.revcomp, max_seq_len, sequence.length); + // create blocks for the motif sites + sites = sequence["sites"]; + for (j = 0; j < sites.length; j++) + make_meme_block(container, max_seq_len, false, sites[j]); + // create blocks for the scanned sites + scan = data.scan[i]; + for (j = 0; j < scan.sites.length; j++) + make_meme_block(container, max_seq_len, true, scan.sites[j]); + // create a row for the sequence + row = tbody.insertRow(tbody.rows.length); + toggle_class(row, "empty_seq", sites.length == 0 && scan.sites.length == 0); + toggle_class(row, "only_scan", sites.length == 0 && scan.sites.length > 0); + add_text_cell(row, (i + 1) + ".", "blockdiag_num"); + add_text_cell(row, sequence["name"], "blockdiag_name"); + add_text_cell(row, scan["pvalue"].toExponential(2), "blockdiag_pvalue"); + add_cell(row, container, "block_td"); + } + return end; +} + +function make_blocks_entries() { + "use strict"; + var region; + region = this; + if (region.data_blocks_index >= data["sequence_db"]["sequences"].length) { + // all sites created + region.removeEventListener('scroll', make_blocks_entries, false); + return; + } + // if there's still 100 pixels to scroll than don't do anything yet + if (region.scrollHeight - (region.scrollTop + region.offsetHeight) > 100) { + return; + } + + region.data_blocks_index = append_blocks_entries( + find_child(region, "blocks_tbl").tBodies[0], + region.data_blocks_index, 20 + ); +} + +function make_blocks() { + "use strict"; + function add_seqs_filter(container, id, checked, label_text, help_topic) { + "use strict"; + var label, radio; + radio = document.createElement("input"); + radio.type = "radio"; + radio.name = "seqs_display"; + radio.id = id; + radio.checked = checked; + radio.addEventListener('click', action_seqs_filter, false); + label = document.createElement("label"); + label.appendChild(document.createTextNode(label_text)); + label.htmlFor = id; + container.appendChild(radio); + container.appendChild(label); + if (help_topic) { + container.appendChild(document.createTextNode("\xA0")); + container.appendChild(help_button(help_topic)); + } + } + function add_blocks_header(row, title, nopad, help_topic) { + "use strict"; + var div, divcp, th; + th = document.createElement("th"); + div = document.createElement("div"); + div.className = "blocks_th_inner"; + if (typeof title !== "object") { + title = document.createTextNode("" + title); + } + div.appendChild(title); + if (help_topic) { + div.appendChild(document.createTextNode("\xA0")); + div.appendChild(help_button(help_topic)); + } + divcp = div.cloneNode(true); + divcp.className = "blocks_th_hidden"; + th.appendChild(div); + th.appendChild(divcp); + if (nopad) { + th.className = "nopad"; + } + row.appendChild(th); + } + var container; + var page, view_height, outer_tbl, inner_tbl, tbl, thead, tbody, rhead; + var in_view, i, seq_count; + + page = (document.compatMode === "CSS1Compat") ? document.documentElement : document.body; + view_height = Math.max(page.clientHeight - 300, 300); + + container = $("blocks"); + toggle_class(container, "hide_empty_seqs", true); + toggle_class(container, "hide_only_scan", true); + container.innerHTML = ""; + add_seqs_filter(container, "rdo_sites_only", true, "Only Motif Sites", "pop_motif_sites"); + add_seqs_filter(container, "rdo_sites_and_scan", false, "Motif Sites+Scanned Sites", "pop_scanned_sites"); + add_seqs_filter(container, "rdo_all_seqs", false, "All Sequences", "pop_all_sequences"); + + outer_tbl = document.createElement("div"); + outer_tbl.className = "blocks_outer"; + + inner_tbl = document.createElement("div"); + inner_tbl.id = "blocks_scroll"; + inner_tbl.className = "blocks_inner"; + inner_tbl.style.maxHeight = view_height + "px"; + outer_tbl.appendChild(inner_tbl); + + tbl = document.createElement("table"); + tbl.className = "blocks_tbl"; + inner_tbl.appendChild(tbl); + + thead = document.createElement("thead"); + tbl.appendChild(thead); + tbody = document.createElement("tbody"); + tbl.appendChild(tbody); + + rhead = thead.insertRow(thead.rows.length); + add_blocks_header(rhead, "", true); + add_blocks_header(rhead, "Name", false, "pop_seq_name"); + add_blocks_header(rhead, make_pv_text(), false, "pop_seq_pvalue"); + add_blocks_header(rhead, "Motif Location", false, "pop_motif_location"); + + container.appendChild(outer_tbl); + + + seq_count = data["sequence_db"]["sequences"].length; + in_view = Math.max(Math.ceil(view_height / 25), 1); + i = append_blocks_entries(tbody, 0, in_view); + + while (i < seq_count && inner_tbl.scrollHeight - (inner_tbl.scrollTop + inner_tbl.offsetHeight) < 400) { + i = append_blocks_entries(tbody, i, 20); + } + inner_tbl.data_blocks_index = i; + if (i < seq_count) { + inner_tbl.addEventListener('scroll', make_blocks_entries, false); + } +} + +function make_scan_popup(site, motif) { + return function (e) { + "use strict"; + var pop, xy, padding, edge_padding, pop_left, pop_top, page_width; + var lflank, match, rflank, pspm; + if (!e) var e = window.event; + pop = make_scan_popup.pop; + if (e.type === "mouseover") { + if (pop) return; + pop = clone_template("tmpl_scan_info"); + pspm = new Pspm(motif.pwm); + if (site.rc) pspm.reverse_complement(meme_alphabet); + set_tvar(pop, "tvar_logo", make_small_logo(meme_alphabet, pspm, {"className": "scan_logo"})); + set_tvar(pop, "tvar_motif", motif.id); + set_tvar(pop, "tvar_pvalue", site.pvalue.toExponential(2)); + set_tvar(pop, "tvar_start", site.pos + 1); + set_tvar(pop, "tvar_end", site.pos + motif.len); + + document.body.appendChild(pop); + position_popup(this, pop); + make_scan_popup.pop = pop; + } else if (e.type === "mouseout") { + if (pop) { + pop.parentNode.removeChild(pop); + make_scan_popup.pop = null; + } + } + }; +} + +function make_block_popup(site, motif, block) { + return function (e) { + "use strict"; + var pop; + var lflank, match, rflank, pspm, ruler, match_seq, match_width; + if (!e) var e = window.event; + pop = make_block_popup.pop; + if (e.type === "mouseover") { + if (pop) return; + pop = clone_template("tmpl_block_info"); + pspm = new Pspm(motif.pwm); + if (site.rc) { // must be dna + pspm.reverse_complement(meme_alphabet); + lflank = meme_alphabet.invcomp_seq(site.rflank); + match = meme_alphabet.invcomp_seq(site.match); + rflank = meme_alphabet.invcomp_seq(site.lflank); + } else { + lflank = site.lflank; + match = site.match; + rflank = site.rflank; + } + ruler = document.getElementById("measure_match"); + match_seq = make_seq(meme_alphabet, match); + ruler.innerHTML = ""; + ruler.appendChild(match_seq); + match_width = ruler.clientWidth; + ruler.removeChild(match_seq); + set_tvar(pop, "tvar_lflank", lflank); + set_tvar(pop, "tvar_match", match_seq); + set_tvar(pop, "tvar_rflank", rflank); + set_tvar(pop, "tvar_logo_pad", lflank); + set_tvar(pop, "tvar_logo", make_small_logo(meme_alphabet, pspm, {"width": match_width})); + set_tvar(pop, "tvar_motif", motif.id); + set_tvar(pop, "tvar_pvalue", site.pvalue.toExponential(2)); + set_tvar(pop, "tvar_start", site.pos + 1); + set_tvar(pop, "tvar_end", site.pos + motif.len); + + document.body.appendChild(pop); + position_popup(block, pop); + make_block_popup.pop = pop; + } else if (e.type === "mouseout") { + if (pop) { + pop.parentNode.removeChild(pop); + make_block_popup.pop = null; + } + } + }; +} + +function update_outpop_format(index) { + switch(parseInt($("text_format").value)) { + case 0: // count matrix + $("outpop_text").value = motif_count_matrix(index); + $("text_name").value = "motif_" + (index + 1) + "_counts.txt"; + break; + case 1: // prob matrix + $("outpop_text").value = motif_prob_matrix(index); + $("text_name").value = "motif_" + (index + 1) + "_freqs.txt"; + break; + case 2: // minimal meme + $("outpop_text").value = motif_minimal_meme(index); + $("text_name").value = "motif_" + (index + 1) + ".txt"; + break; + case 3: // fasta + $("outpop_text").value = motif_fasta(index); + $("text_name").value = "motif_" + (index + 1) + "_fasta.txt"; + break; + case 4: // raw + $("outpop_text").value = motif_raw(index); + $("text_name").value = "motif_" + (index + 1) + "_raw.txt"; + break; + default: + throw new Error("Unknown motif format"); + } +} + +function update_outpop_motif(index) { + "use strict"; + var motifs, motif, pspm, logo, canvas, num; + motifs = data["motifs"]; + if (index < 0 || index >= motifs.length) {return;} + current_motif = index; + motif = motifs[index]; + pspm = new Pspm(motif["pwm"]); + logo = new Logo(meme_alphabet, ""); + logo.add_pspm(pspm, 0); + canvas = $("outpop_logo"); + canvas.width = canvas.width; // clear canvas + draw_logo_on_canvas(logo, canvas, false); + if (meme_alphabet.has_complement()) { + pspm.reverse_complement(meme_alphabet); + logo = new Logo(meme_alphabet, ""); + canvas = $("outpop_logo_rc"); + canvas.width = canvas.width; // clear canvas + draw_logo_on_canvas(logo, canvas, false); + } + num = $("outpop_num"); + num.innerHTML = ""; + num.appendChild(document.createTextNode("" + (index + 1))); + update_outpop_format(index); +} + +// +// action_show_more +// +// Show more information on the motif. +/// +function action_show_more(e) { + var node, tr, tbody, table, container, motif, ordinal; + var expanded_motif; + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + // find the row that contains the cell + node = this; + do { + if (node.tagName === "TR") break; + } while (node = node.parentNode); + if (!node) throw new Error("Expected to find row!?"); + tr = node; + // get info + motif = tr.data_motif; + ordinal = tr.data_ordinal; + // find tbody + do { + if (node.tagName === "TBODY") break; + } while (node = node.parentNode); + if (!node) throw new Error("Expected to find tbody!?"); + tbody = node; + // find table + do { + if (node.tagName === "TABLE") break; + } while (node = node.parentNode); + if (!node) throw new Error("Expected to find table!?"); + table = node; + // find container + container = node.parentNode; + // make a expanded motif + motif["expanded"] = true; + expanded_motif = make_expanded_motif(meme_alphabet, ordinal, motif, + container.data_more_x, container.data_submit_x); + // now determine how to place it + if (tbody.rows.length === 1) { + // only us in the table so the table can be replaced + container.replaceChild(expanded_motif, table); + } else if (tbody.rows[0] === tr) { + // first row, so remove and insert an expanded motif before + table.deleteRow(tr.rowIndex); + container.insertBefore(expanded_motif, table); + } else if (tbody.rows[tbody.rows.length -1] === tr) { + // last row, so remove and insert an expanded motif after + table.deleteRow(tr.rowIndex); + container.insertBefore(expanded_motif, table.nextSibling); + } else { + var table2, tbody2; + table2 = table.cloneNode(false); + table2.appendChild(table.tHead.cloneNode(true)); + tbody2 = table.tBodies[0].cloneNode(false); + table2.appendChild(tbody2); + container.insertBefore(table2, table.nextSibling); + for (i = tbody.rows.length - 1; i >= 0; i--) { + row = tbody.rows[i]; + row.parentNode.removeChild(row); + if (row === tr) { + break; + } + tbody2.insertBefore(row, tbody2.rows[0]); + } + container.insertBefore(expanded_motif, table2); + } + find_child(expanded_motif, "tvar_less").focus(); +} + +// +// action_show_less +// +// Show less information on the motif. +/// +function action_show_less(e) { + var btn; + var expanded_motif, container, motif, ordinal, colw, focus_target; + var table, tbody, tbody2, row, table_before, table_after; + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + btn = this; + // find expanded motif + expanded_motif = find_parent(btn, "expanded_motif"); + if (!expanded_motif) throw new Error("Expected expanded motif."); + // find the container + container = expanded_motif.parentNode; + // get data + motif = expanded_motif.data_motif; + ordinal = expanded_motif.data_ordinal; + colw = container.data_colw; + // get the table before + table_before = expanded_motif.previousSibling; + if (table_before && table_before.tagName !== "TABLE") { + table_before = null; + } + // get the table after + table_after = expanded_motif.nextSibling; + if (table_after && table_after.tagName !== "TABLE") { + table_after = null; + } + // see if there is a table below or above that we can put this in. + // if there is a table both below and above then add this motif and + // all ones below to the above table + motif["expanded"] = false; + if (table_before && table_after) { + tbody = table_before.tBodies[0]; + row = tbody.insertRow(tbody.rows.length); + make_motif_table_entry(row, meme_alphabet, ordinal, motif, colw); + focus_target = find_child(row.cells[5], "sym_btn"); + container.removeChild(expanded_motif); + tbody2 = table_after.tBodies[0]; + while (tbody2.rows.length > 0) { + row = tbody2.rows[0]; + row.parentNode.removeChild(row); + tbody.appendChild(row); + } + container.removeChild(table_after); + } else if (table_before) { + tbody = table_before.tBodies[0]; + row = tbody.insertRow(tbody.rows.length); + make_motif_table_entry(row, meme_alphabet, ordinal, motif, colw); + focus_target = find_child(row.cells[5], "sym_btn"); + container.removeChild(expanded_motif); + } else if (table_after) { + tbody = table_after.tBodies[0]; + row = tbody.insertRow(0); + make_motif_table_entry(row, meme_alphabet, ordinal, motif, colw); + focus_target = find_child(row.cells[5], "sym_btn"); + container.removeChild(expanded_motif); + } else { + //no table above or below! + // make a new table + table = make_motifs_table(meme_alphabet, ordinal, [motif], colw, data["stop_reason"]); + focus_target = find_child(table.tBodies[0].rows[0].cells[5], "sym_btn"); + container.replaceChild(table, expanded_motif); + } + focus_target.focus(); +} + +function action_show_outpop(e) { + "use strict"; + function init() { + "use strict"; + var close_btn, next_btn, prev_btn, cancel_btn, do_btn; + var tab1, tab2, tab3; + var pnl1, pnl2, pnl3; + var format_list; + var tbl_submit, inputs, i, default_prog; + close_btn = $("outpop_close"); + close_btn.addEventListener("click", action_hide_outpop, false); + close_btn.addEventListener("keydown", action_hide_outpop, false); + next_btn = $("outpop_next"); + next_btn.addEventListener("click", action_outpop_next, false); + next_btn.addEventListener("keydown", action_outpop_next, false); + prev_btn = $("outpop_prev"); + prev_btn.addEventListener("click", action_outpop_prev, false); + prev_btn.addEventListener("keydown", action_outpop_prev, false); + cancel_btn = $("outpop_cancel"); + cancel_btn.addEventListener("click", action_hide_outpop, false); + do_btn = $("outpop_do"); + do_btn.addEventListener("click", action_outpop_submit, false); + tab1 = $("outpop_tab_1"); + tab1.tabIndex = 0; + tab1.addEventListener("click", action_outpop_tab, false); + tab1.addEventListener("keydown", action_outpop_tab, false); + tab2 = $("outpop_tab_2"); + tab2.tabIndex = 0; + tab2.addEventListener("click", action_outpop_tab, false); + tab2.addEventListener("keydown", action_outpop_tab, false); + tab3 = $("outpop_tab_3"); + tab3.tabIndex = 0; + tab3.addEventListener("click", action_outpop_tab, false); + tab3.addEventListener("keydown", action_outpop_tab, false); + pnl1 = $("outpop_pnl_1"); + pnl2 = $("outpop_pnl_2"); + pnl3 = $("outpop_pnl_3"); + toggle_class(tab1, "activeTab", true); + toggle_class(tab2, "activeTab", false); + toggle_class(tab3, "activeTab", false); + pnl1.style.display = "block"; + pnl2.style.display = "none"; + pnl3.style.display = "none"; + format_list = $("text_format"); + format_list.addEventListener("change", action_outpop_format, false); + // setup program selection + tbl_submit = $("programs"); + // when not dna, hide the inputs for programs that require dna motifs + toggle_class(tbl_submit, "alphabet_dna", meme_alphabet.has_complement());//TODO FIXME alphabet_dna is a bad name for a field when allowing custom alphabets + // add a click listener for the radio buttons + inputs = tbl_submit.querySelectorAll("input[type='radio']"); + for (i = 0; i < inputs.length; i++) { + inputs[i].addEventListener("click", action_outpop_program, false); + } + // ensure that a default program option is selected for DNA and Protein + default_prog = document.getElementById(meme_alphabet.has_complement() ? "submit_tomtom" : "submit_fimo"); //TODO FIXME Tomtom might require a more strict definition of DNA + default_prog.checked = true; + action_outpop_program.call(default_prog); + // disable reverse-complement when not DNA + $("logo_rc_option").disabled = !meme_alphabet.has_complement(); + // set errorbars on when ssc is on + $("logo_ssc").addEventListener("change", action_outpop_ssc, false); + } + var node; + // store the focused element + action_hide_outpop.last_active = document.activeElement; + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + // hide the help popup + help_popup(); + // on first load initilize the popup + if (!action_show_outpop.ready) { + init(); + action_show_outpop.ready = true; + } + // load the motif logo + node = this; + do { + if (/\bexpanded_motif\b/.test(node.className) || node.tagName === "TR") break; + } while (node = node.parentNode); + if (node === null) throw new Error("Expected node!"); + update_outpop_motif(node.data_ordinal - 1); + // display the download popup + $("grey_out_page").style.display = "block"; + $("download").style.display = "block"; + $("outpop_close").focus(); +} + +function action_hide_outpop(e) { + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + $("download").style.display = "none"; + $("grey_out_page").style.display = "none"; + if (typeof action_hide_outpop.last_active !== "undefined") { + action_hide_outpop.last_active.focus(); + } +} + +function action_outpop_next(e) { + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + update_outpop_motif(current_motif + 1); +} + +function action_outpop_prev(e) { + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + update_outpop_motif(current_motif - 1); +} + +function action_outpop_program() { + "use strict"; + var table, tr, rows, i; + tr = find_parent_tag(this, "TR"); + table = find_parent_tag(tr, "TABLE"); + rows = table.querySelectorAll("tr"); + for (i = 0; i < rows.length; i++) { + toggle_class(rows[i], "selected", rows[i] === tr); + } +} + +function action_outpop_ssc() { + "use strict"; + $("logo_err").value = $("logo_ssc").value; +} + +function action_outpop_submit(e) { + "use strict"; + var form, input, program, motifs; + // find out which program is selected + var radios, i; + radios = document.getElementsByName("program"); + program = "fimo"; // default to fimo, since it works with all alphabet types + for (i = 0; i < radios.length; i++) { + if (radios[i].checked) program = radios[i].value; + } + + motifs = motif_minimal_meme(current_motif); + form = document.createElement("form"); + form.setAttribute("method", "post"); + form.setAttribute("action", site_url + "/tools/" + program); + + input = document.createElement("input"); + input.setAttribute("type", "hidden"); + input.setAttribute("name", "motifs_embed"); + input.setAttribute("value", motifs); + form.appendChild(input); + + document.body.appendChild(form); + form.submit(); + document.body.removeChild(form); +} + +function action_outpop_download_motif(e) { + $("text_form").submit(); +} + +function action_outpop_download_logo(e) { + "use strict"; + $("logo_motifs").value = motif_minimal_meme(current_motif); + $("logo_form").submit(); +} + +function action_btn_rc(e) { + "use strict"; + var node, tr, motif, box, logo_box, tab_st, tab_rc, rc; + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + node = this; + do { + if (node.tagName === "TR") break; + } while (node = node.parentNode); + if (!node) throw new Error("Expected to find row!?"); + tr = node; + // get info + motif = tr.data_motif; + box = find_parent(this, "preview_box"); + logo_box = find_child(box, "preview_logo_box"); + tab_st = find_child(box, "plus"); + tab_rc = find_child(box, "minus"); + rc = (this === tab_rc); + motif["rc"] = rc; + toggle_class(logo_box, "show_rc_logo", rc); + toggle_class(tab_st, "active", !rc); + toggle_class(tab_rc, "active", rc); +} + +function action_rc_tab(e) { + "use strict"; + var box, logo_box, tab_st, tab_rc, rc; + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + box = find_parent(this, "expanded_motif"); + logo_box = find_child(box, "tvar_logo"); + tab_st = find_child(box, "tvar_tab"); + tab_rc = find_child(box, "tvar_tab_rc"); + rc = (this === tab_rc); + box.data_motif["rc"] = rc; + toggle_class(logo_box, "show_rc_logo", rc); + toggle_class(tab_st, "activeTab", !rc); + toggle_class(tab_rc, "activeTab", rc); +} + +function action_outpop_tab(e) { + "use strict"; + var tab1, tab2, tab3, pnl1, pnl2, pnl3, do_btn; + if (!e) e = window.event; + if (e.type === "keydown") { + if (e.keyCode !== 13 && e.keyCode !== 32) { + return; + } + // stop a submit or something like that + e.preventDefault(); + } + tab1 = $("outpop_tab_1"); + tab2 = $("outpop_tab_2"); + tab3 = $("outpop_tab_3"); + pnl1 = $("outpop_pnl_1"); + pnl2 = $("outpop_pnl_2"); + pnl3 = $("outpop_pnl_3"); + do_btn = $("outpop_do"); + + toggle_class(tab1, "activeTab", (this === tab1)); + toggle_class(tab2, "activeTab", (this === tab2)); + toggle_class(tab3, "activeTab", (this === tab3)); + pnl1.style.display = ((this === tab1) ? "block" : "none"); + pnl2.style.display = ((this === tab2) ? "block" : "none"); + pnl3.style.display = ((this === tab3) ? "block" : "none"); + do_btn.value = ((this === tab1) ? "Submit" : "Download"); + do_btn.removeEventListener("click", action_outpop_submit, false); + do_btn.removeEventListener("click", action_outpop_download_logo, false); + do_btn.removeEventListener("click", action_outpop_download_motif, false); + if (this === tab1) { + do_btn.addEventListener("click", action_outpop_submit, false); + } else if (this === tab2) { + do_btn.addEventListener("click", action_outpop_download_motif, false); + } else { + do_btn.addEventListener("click", action_outpop_download_logo, false); + } +} + +function action_seqs_filter() { + "use strict"; + var block_container; + block_container = $("blocks"); + if ($("rdo_all_seqs").checked) { + toggle_class(block_container, "hide_empty_seqs", false); + toggle_class(block_container, "hide_only_scan", false); + } else if ($("rdo_sites_and_scan").checked) { + toggle_class(block_container, "hide_empty_seqs", true); + toggle_class(block_container, "hide_only_scan", false); + } else if ($("rdo_sites_only").checked) { + toggle_class(block_container, "hide_empty_seqs", true); + toggle_class(block_container, "hide_only_scan", true); + } +} + +function action_outpop_format() { + update_outpop_format(current_motif); +} + +// +// page_loaded +// +// Called when the page has loaded for the first time. +/// +function page_loaded() { + post_load_setup(); +} + +// +// page_loaded +// +// Called when a cached page is reshown. +/// +function page_shown(e) { + if (e.persisted) post_load_setup(); +} + +// +// page_loaded +// +// Called when the page is resized +/// +function page_resized() { + var page, blocks_scroll; + update_scroll_pad(); + page = (document.compatMode === "CSS1Compat") ? document.documentElement : document.body; + blocks_scroll = $("blocks_scroll"); + if (blocks_scroll) { + blocks_scroll.style.maxHeight = Math.max(page.clientHeight - 300, 300) + "px"; + } +} + +// +// pre_load_setup +// +// Run before the page is displayed +/// +function pre_load_setup() { + var start, hue, sat, light, divisions; + var i, j, motifs, motif, sites, site, sequences, sequence; + var max_seq_len; + motifs = data["motifs"]; + sequences = data["sequence_db"]["sequences"]; + max_seq_len = 1; + for (i = 0; i < sequences.length; i++) { + sequence = sequences[i]; + sequence["sites"] = []; + if (sequence["length"] > max_seq_len) { + max_seq_len = sequence["length"]; + } + } + data["sequence_db"]["max_length"] = max_seq_len; + // use hsl colours + start = 0; //red + sat = 100; + light = 50; + for (i = 0; i < motifs.length; i++) { + motif = motifs[i]; + // give the motif a colour + divisions = 1 << Math.ceil(Math.log(i + 1) / Math.LN2); + hue = start + (360 / divisions) * ((i - (divisions >> 1)) * 2 + 1); + motif["colour"] = "hsl(" + hue + ", " + sat + "%, " + light + "%)"; + // associate sites with sequences as well + // to make generating the block diagram easier + sites = motif["sites"]; + for (j = 0; j < sites.length; j++) { + site = sites[j]; + sequence = sequences[site["seq"]]; + // record the motif index + site["motif"] = i; + // add the site to the sequence + sequence["sites"].push(site); + } + } +} + +// +// post_load_setup +// +// Run when the page has loaded, or been reloaded. +// +function post_load_setup() { + update_scroll_pad(); + if (data["motifs"].length > 0) { + make_motifs(); + make_blocks(); + } else { + $("motifs").innerHTML = "<p>No significant motifs found!</p>"; // clear content + $("motifs").innerHTML += "<p><b>" + data["stop_reason"] + "</b></p>"; + $("blocks").innerHTML = "<p>No significant motifs found!</p>"; + } +} + +pre_load_setup(); +</script> + <style> +/* The following is the content of meme.css */ +body { background-color:white; font-size: 12px; font-family: Verdana, Arial, Helvetica, sans-serif;} + +div.help { + display: inline-block; + margin: 0px; + padding: 0px; + width: 12px; + height: 13px; + cursor: pointer; + background-image: url(data:image/gif;base64,R0lGODlhDAANAIABANR0AP///yH5BAEAAAEALAAAAAAMAA0AAAIdhI8Xy22MIFgv1DttrrJ7mlGNNo4c+aFg6SQuUAAAOw==); +} + +div.help:hover { + background-image: url(data:image/gif;base64,R0lGODlhDAANAKEAANR0AP///9R0ANR0ACH+EUNyZWF0ZWQgd2l0aCBHSU1QACH5BAEAAAIALAAAAAAMAA0AAAIdDGynCe3PgoxONntvwqz2/z2K2ImjR0KhmSIZUgAAOw==); +} + +p.spaced { line-height: 1.8em;} + +span.citation { font-family: "Book Antiqua", "Palatino Linotype", serif; color: #004a4d;} + +p.pad { padding-left: 30px; padding-top: 5px; padding-bottom: 10px;} + +td.jump { font-size: 13px; color: #ffffff; background-color: #00666a; + font-family: Georgia, "Times New Roman", Times, serif;} + +a.jump { margin: 15px 0 0; font-style: normal; font-variant: small-caps; + font-weight: bolder; font-family: Georgia, "Times New Roman", Times, serif;} + +h2.mainh {font-size: 1.5em; font-style: normal; margin: 15px 0 0; + font-variant: small-caps; font-family: Georgia, "Times New Roman", Times, serif;} + +h2.line {border-bottom: 1px solid #CCCCCC; font-size: 1.5em; font-style: normal; + margin: 15px 0 0; padding-bottom: 3px; font-variant: small-caps; + font-family: Georgia, "Times New Roman", Times, serif;} + +h4 {border-bottom: 1px solid #CCCCCC; font-size: 1.2em; font-style: normal; + margin: 10px 0 0; padding-bottom: 3px; font-family: Georgia, "Times New Roman", Times, serif;} + +h5 {margin: 0px} + +a.help { font-size: 9px; font-style: normal; text-transform: uppercase; + font-family: Georgia, "Times New Roman", Times, serif;} + +div.pad { padding-left: 30px; padding-top: 5px; padding-bottom: 10px;} + +div.pad1 { margin: 10px 5px;} + +div.pad2 { margin: 25px 5px 5px;} +h2.pad2 { padding: 25px 5px 5px;} + +div.pad3 { padding: 5px 0px 10px 30px;} + +div.box { border: 2px solid #CCCCCC; padding:10px; overflow: hidden;} + +div.bar { border-left: 7px solid #00666a; padding:5px; margin-top:25px; } + +div.subsection {margin:25px 0px;} + +img {border:0px none;} + +th.majorth {text-align:left;} +th.minorth {font-weight:normal; text-align:left; width:8em; padding: 3px 0px;} +th.actionth {font-weight:normal; text-align:left;} + +.explain h5 {font-size:1em; margin-left: 1em;} + +div.doc {margin-left: 2em; margin-bottom: 3em;} + +th.trainingset { + border-bottom: thin dashed black; + font-weight:normal; + padding:0px 10px; +} +div.pop_content { + position:absolute; + z-index:50; + width:300px; + padding: 5px; + background: #E4ECEC; + font-size: 12px; + font-family: Arial; + border-style: double; + border-width: 3px; + border-color: #AA2244; + display:none; +} + +div.pop_content > *:first-child { + margin-top: 0px; +} + +div.pop_content h1, div.pop_content h2, div.pop_content h3, div.pop_content h4, +div.pop_content h5, div.pop_content h6, div.pop_content p { + margin: 0px; +} + +div.pop_content p + h1, div.pop_content p + h2, div.pop_content p + h3, +div.pop_content p + h4, div.pop_content p + h5, div.pop_content p + h6 { + margin-top: 5px; +} + +div.pop_content p + p { + margin-top: 5px; +} + +div.pop_content > *:last-child { + margin-bottom: 0px; +} + +div.pop_content div.pop_close { + /* old definition */ + float:right; + bottom: 0; +} + +div.pop_content span.pop_close, div.pop_content span.pop_back { + display: inline-block; + border: 2px outset #661429; + background-color: #CCC; + padding-left: 1px; + padding-right: 1px; + padding-top: 0px; + padding-bottom: 0px; + cursor: pointer; + color: #AA2244; /*#661429;*/ + font-weight: bold; +} + +div.pop_content span.pop_close:active, div.pop_content span.pop_back:active { + border-style: inset; +} + +div.pop_content span.pop_close { + float:right; + /*border: 2px outset #AA002B;*/ + /*color: #AA2244;*/ +} + +div.pop_content:not(.nested) .nested_only { + display: none; +} + +div.pop_back_sec { + margin-bottom: 5px; +} + +div.pop_close_sec { + margin-top: 5px; +} + +table.hide_advanced tr.advanced { + display: none; +} +span.show_more { + display: none; +} +table.hide_advanced span.show_more { + display: inline; +} +table.hide_advanced span.show_less { + display: none; +} + + +/***************************************************************************** + * Program logo styling + ****************************************************************************/ +div.prog_logo { + border-bottom: 0.25em solid #0f5f60; + height: 4.5em; + width: 24em; + display:inline-block; +} +div.prog_logo img { + float:left; + width: 4em; + border-style: none; + margin-right: 0.2em; +} +div.prog_logo h1, div.prog_logo h1:hover, div.prog_logo h1:active, div.prog_logo h1:visited { + margin:0; + padding:0; + font-family: Arial, Helvetica, sans-serif; + font-size: 3.2em; + line-height: 1em; + vertical-align: top; + display: block; + color: #026666; + letter-spacing: -0.06em; + text-shadow: 0.04em 0.06em 0.05em #666; +} +div.prog_logo h2, div.prog_logo h2:hover, div.prog_logo h2:active, div.prog_logo h2:visited { + display: block; + margin:0; + padding:0; + font-family: Helvetica, sans-serif; + font-size: 0.9em; + line-height: 1em; + letter-spacing: -0.06em; + color: black; +} + +div.big.prog_logo { + font-size: 18px; +} + +</style> + <style> +.block_td { + height:25px; +} +.block_container { + position:relative; + box-sizing: border-box; + height: 25px; + padding: 0px; + margin: 0px; + margin-left: 1em; +} +.block_label { + position: absolute; + display: inline-block; + padding: 3px; + z-index: 4; + top: 6px; + height: 12px; + line-height: 12px; + font-size: 12px; + background-color: white; + border: 1px solid black; + -moz-border-radius: 12px; + -webkit-border-radius: 12px; + border-radius: 12px; + transform: translateX(-50%); +} +.block_motif { + position: absolute; + z-index: 3; + top: 0px; + box-sizing: border-box; + border: 1px solid black; + height: 12px; + background-color: cyan; +} +.block_motif.top { + border-bottom-width: 0; +} +.block_motif.bottom { + border-top-width: 0; +} +.block_motif.scanned_site { + opacity: 0.3; +} +.block_motif.scanned_site.active { + opacity: 0.9; +} +.block_region { + position:absolute; + z-index:6; + height:25px; + top:0px; +} +.block_region.main { + z-index:8; +} +.block_region.scanned_site { + z-index:5; +} +.block_region.scanned_site.main { + z-index:7; +} +.block_region.top { + height:13px; +} +.block_region.bottom { + height:13px; + top:12px; +} +.block_rule { + position:absolute; + z-index:2; + width:100%; + height:1px; + top:12px; + left:0px; + background-color:gray; +} +.block_plus_sym { + position:absolute; + z-index:4; + line-height:12px; + top:0px; + left:-1em; +} +.block_minus_sym { + position:absolute; + z-index:4; + line-height:12px; + top:13px; + left:-1em; +} + +.tic_major { + position:absolute; + top:0em; + height:0.5em; + width: 2px; + margin-left: -1px; + background-color: blue; +} +.tic_minor { + position:absolute; + top:0em; + height:0.2em; + width: 1px; + margin-left: -0.5px; + background-color: blue; +} +.tic_label { + position:absolute; + display: inline-block; + top:0.5em; + height: 1em; + color: blue; + transform: translateX(-50%); +} + +.block_needle { + position:absolute; + z-index:4; + height:30px; + width:1px; + top:-2px; + background-color:gray; +} +.block_needle.right { + height: 60px; +} +.block_handle { + position: absolute; + display: inline-block; + z-index: 5; + top: 27px; + min-width: 3ex; + text-align: center; + font-size: 12px; + line-height: 12px; + transform: translateX(-50%); + background-color: LightGrey; + border:3px outset grey; + cursor: pointer; + -webkit-user-select: none; /* Chrome/Safari */ + -moz-user-select: none; /* Firefox */ + -ms-user-select: none; /* IE10+ */ + /* Rules below not implemented in browsers yet */ + -o-user-select: none; + user-select: none; +} +.block_handle.right { + top: 47px; +} + +.legend_container { + text-align: right; +} +.legend_entry { + display: inline-block; + padding: 5px; +} +div.legend_swatch { + box-sizing: border-box; + width: 15px; + height: 15px; + border: 1px solid black; + background-color: cyan; + float: left; +} +div.legend_swatch input { + display: none; +} +.legend_text { + line-height: 15px; + margin-left: 20px; +} +</style> + <style> +/* meme output specific css */ + +div.pop_block { + position:absolute; + z-index:5; + padding: 5px; + border: 1px solid black; + display: inline-block; + background-color: white; +} + +#measure_match { + position: absolute; + visibility: hidden; + height: auto; + width: auto; + white-space: nowrap; +} + +div.template { + position: absolute; + z-index: 1; + left: 0; + top: 0; + visibility: hidden; +} + +table.block_information { + margin-left: auto; + margin-right: auto; +} + +table.block_information * th { + text-align: right; +} + +*.hide_empty_seqs * tr.empty_seq { + display: none; +} + +*.hide_only_scan * tr.only_scan { + display: none; +} + +*.hide_only_scan * div.scanned_site { + display: none; +} + +td.symaction { + text-align: center; + text-decoration: underline; + font-size: 20px; + cursor: pointer; +} +div.sym_btn { + display:inline-block; + text-decoration: underline; + cursor: pointer; + font-size: 20px; + line-height:20px; + text-align: center; + width: 20px; + height: 20px; + color: blue; +} +div.sym_btn:hover { + color: white; + background-color: blue; +} + +div.sym_btn.positioned { + position: absolute; + top: 0px; +} + +div.actionbutton { + display:inline-block; + cursor: pointer; + font-size: 18px; + line-height:20px; + padding: 5px; + margin: 10px 0; + border: 1px solid black; +} + +div.actionbutton:hover { + color:#FFF; + background-color:#000; +} + +div.param_box { + display: inline-block; + margin-right: 20px; +} + +span.param { + font-weight: bold; +} + +div.box + div.box { + margin-top: 5px; +} + +div.sites_outer { + position: relative; + padding-top: 20px; /* height of header */ + display: inline-block; +} + +div.sites_inner { + overflow-x: hidden; + overflow-y: auto; + max-height: 200px; +} +table.sites_tbl { + border-collapse: collapse; +} + +div.sites_th_inner { + position: absolute; + top: 0; + line-height: 20px; /* height of header */ + text-align: left; + padding-left: 5px; +} +th.nopad div.sites_th_inner { + padding-left: 0; +} +div.sites_th_hidden { + visibility: hidden; + height: 0; + padding: 0 10px; +} +th.nopad div.sites_th_hidden { + padding: 0; +} +div.sites_inner * th { + height: 0; +} + +table.sites_tbl { + overflow-x: hidden; + overflow-y: auto; +} + +.site_num { + text-align: right; +} +.site_name { + padding:0px 5px; + text-align:left; +} +.site_strand { + padding:0px 5px; + text-align:center; +} +.norc .site_strand, .norc .site_strand_title { + display: none; +} +.site_start { + padding:0px 15px; + text-align: right; +} +.site_pvalue { + text-align:center; + padding:0px 15px; + text-align:right; + white-space: nowrap; +} +.lflank, .rflank, .match, .alpha_symbol { + font-weight:bold; + font-size:15px; + font-family: 'Courier New', Courier, monospace; + color:gray; +} + +.site.lflank { + text-align:right; + padding-right:5px; + color:gray; +} +.site.match { + text-align:center; +} +.site.rflank { + text-align:left; + padding-left:5px; + padding-right: 20px; +} + +th.stop_reason { + text-align: left; + padding-right: 10px; +} + +th.motif_ordinal { + +} +td.motif_ordinal { + text-align: right; + padding-right: 10px; +} +th.motif_logo { + padding-right: 10px; +} +td.motif_logo { + padding-right: 10px; +} +th.motif_evalue { + text-align:right; + padding-right: 10px; +} +td.motif_evalue { + text-align: right; + white-space: nowrap; + padding-right: 20px; +} +th.motif_nsites { + text-align: right; + padding-right: 10px; +} +td.motif_nsites { + text-align: right; + padding-right: 20px; +} +th.motif_width { + text-align: right; + padding-right: 5px; +} +td.motif_width { + text-align: right; + padding-right: 15px; +} +th.motif_more { + padding: 0 5px; +} +td.motif_more { + text-align: center; + padding: 0 5px; +} +th.motif_submit { + padding: 0 5px; +} +td.motif_submit { + text-align: center; + padding: 0 5px; +} +th.motif_download { + padding-left: 5px; +} +td.motif_download { + text-align: center; + padding-left: 5px; +} + + +div.tabArea { + font-size: 80%; + font-weight: bold; +} + +.norc div.tabArea { + display: none; +} + +span.tab, span.tab:visited { + cursor: pointer; + color: #888; + background-color: #ddd; + border: 2px solid #ccc; + padding: 2px 1em; + text-decoration: none; +} +span.tab.middle { + border-left-width: 0px; +} +div.tabArea.base span.tab { + border-top-width: 0px; +} +div.tabArea.top span.tab { + border-bottom-width: 0px; +} + +span.tab:hover { + background-color: #bbb; + border-color: #bbb; + color: #666; +} +span.tab.activeTab, span.tab.activeTab:hover, span.tab.activeTab:visited { + background-color: white; + color: black; + cursor: default; +} +div.tabMain { + border: 2px solid #ccc; + background-color: white; + padding: 10px; +} +div.tabMain.base { + margin-top: 5px; + display: inline-block; + max-width: 98%; +} + +div.tabMain.top { + margin-bottom: 5px; +} + +div.tabCenter { + max-width: 100%; + overflow-x: auto; + height: 200px; + overflow-y: hidden; +} + +canvas.logo_rc { + display:none; +} +.show_rc_logo > canvas { + display: none; +} +.show_rc_logo > canvas.logo_rc { + display: block; +} + +canvas.scan_logo { + margin-left: 10px; +} + +div.blocks_outer { + position: relative; + padding-top: 20px; /* height of header */ +} + +div.blocks_inner { + overflow-x: hidden; + overflow-y: auto; + max-height: 200px; +} +table.blocks_tbl { + border-collapse: collapse; + width: 100%; +} + +div.blocks_th_inner { + position: absolute; + top: 0; + line-height: 20px; /* height of header */ + text-align: left; + padding-left: 5px; +} +th.nopad div.blocks_th_inner { + padding-left: 0; +} +div.blocks_th_hidden { + visibility: hidden; + height: 0; + padding: 0 10px; +} +th.nopad div.blocks_th_hidden { + padding: 0; +} +div.blocks_inner * th { + height: 0; +} + +table.blocks_tbl { + overflow-x: hidden; + overflow-y: auto; +} +td.block_td { + width: 99%; +} + +*.blockdiag_num { + text-align: right; +} + +td.blockdiag_name { + text-align: left; + padding:0px 10px; +} + +td.blockdiag_pvalue { + padding:0px 10px; + text-align:right; + white-space: nowrap; +} + +div.preview_btn { + border: 2px solid white; + height: 16px; + width: 16px; + font-size: 12px; + line-height: 16px; + text-align: center; + cursor: pointer; +} +div.preview_btn + div.preview_btn { + margin-top: 3px; +} + +div.preview_btn.active { + border: 2px solid black; + cursor: default; +} + +div.preview_btn:hover { + background-color: black; + color: white; + border-color: black; +} + +div.preview_btn.active:hover { + background-color: white; + color: black; + border-color: black; +} + + +div.preview_btn_box { + position: absolute; + left: 0px; + top: 0px; + padding: 3px; +} + +div.preview_logo_box { + height: 50px; + overflow-y: hidden; +} + +div.preview_btn_box + div.preview_logo_box { + margin-left: 25px; +} + +div.preview_box { + position: relative; +} + +div.grey_background { + position:fixed; + z-index: 8; + background-color: #000; + -ms-filter: "progid:DXImageTransform.Microsoft.Alpha(Opacity=50)"; + opacity: 0.5; + left: 0; + top: 0; + width: 100%; + height: 100%; +} + +div.popup_wrapper { + position:fixed; + z-index:9; + width:100%; + height:0; + top:50%; + left:0; +} + +div.popup { + width: 600px; + z-index:9; + margin-left: auto; + margin-right: auto; + padding: 5px; + background-color: #FFF; + border-style: double; + border-width: 5px; + border-color: #00666a; + position:relative; +} +div.close { + cursor: pointer; + border: 1px solid black; + width:15px; + height:15px; + line-height:15px; /* this causes vertical centering */ + text-align:center; + background-color:#FFF; + color:#000; + font-size:15px; + font-family:monospace; +} + +div.close:hover { + color:#FFF; + background-color:#000; +} + +div.navnum { + width:100%; + height:20px; + line-height:20px; + text-align:center; + font-size:medium; +} + +div.navarrow { + font-size: 30px; + text-decoration:none; + cursor: pointer; + -moz-user-select: none; + -webkit-user-select: none; + -ms-user-select: none; +} + +div.navarrow > span.inactive { + display: inline; +} +div.navarrow > span.active { + display: none; +} + +div.navarrow:hover > span.active { + display: inline; +} +div.navarrow:hover > span.inactive { + display: none; +} + +table.programs { + width: 100%; +} + +table.programs tr { + background-color: #EFE; +} + +table.programs tr.selected { + background-color: #262; + color: #FFF; +} + +table.programs tr.dna_only { + display: none; +} + +table.programs.alphabet_dna tr.dna_only { + display: table-row; +} + +div.programs_scroll { + width: 100%; + height: 90px; + overflow-y: auto; + overflow-x: hidden; + margin: 0 auto; +} +table.inputs, table.alpha_bg_table { + margin-top: 20px; + border-collapse:collapse; +} +table.inputs * td, table.inputs * th, table.alpha_bg_table * td, table.alpha_bg_table * th { + padding-left: 15px; + padding-right: 15px; + padding-top: 1px; + padding-bottom: 1px; +} + +table.hide_psp td.col_psp, table.hide_psp th.col_psp { + display: none; +} + +/* program settings */ +span.mod_oops, span.mod_zoops, span.mod_anr { + display: none; +} +td.oops span.mod_oops,td.zoops span.mod_zoops, td.anr span.mod_anr { + display: inline; +} +span.strand_none, span.strand_given, span.strand_both { + display: none; +} +td.none span.strand_none, td.given span.strand_given, td.both span.strand_both { + display: inline; +} +span.spmap_uni, span.spmap_pam { + display: none; +} +td.uni span.spmap_uni, td.pam span.spmap_pam { + display: inline; +} +span.prior_dirichlet, span.prior_dmix, span.prior_mega, span.prior_megap, span.prior_addone { + display: none; +} +td.dirichlet span.prior_dirichlet, td.dmix span.prior_dmix, td.mega span.prior_mega, +td.megap span.prior_megap, td.addone span.prior_addone { + display: inline; +} +span.noendgaps_on, span.noendgaps_off { + display: none; +} +td.on span.noendgaps_on, td.off span.noendgaps_off { + display: inline; +} +span.substring_on, span.substring_off { + display: none; +} +td.on span.substring_on, td.off span.substring_off { + display: inline; +} +</style> + </head> + <body onload="page_loaded()" onpageshow="page_shown(event)" onresize="page_resized()"> + <!-- --> + <div id="grey_out_page" class="grey_background" style="display:none;"> + </div> + <!-- Help popups --> + <div class="pop_content" id="pop_"> + <p>Help poup.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_ev"> + <p>The statistical significance of the motif. MEME usually finds the most + statistically significant (low E-value) motifs first. It is unusual to + consider a motif with an E-value larger than 0.05 significant so, as an + additional indicator, MEME displays these partially transparent.</p> + <p>The E-value of a motif is based on its log likelihood ratio, width, + sites, the background letter frequencies (given in the command line + summary), and the size of the training set.</p> + <p>The E-value is an estimate of the expected number of motifs with the + given log likelihood ratio (or higher), and with the same width and site + count, that one would find in a similarly sized set of random + sequences (sequences where each position is independent and letters are + chosen according to the background letter frequencies).</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_sites"> + <p>The number of sites contributing to the construction of the motif.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_width"> + <p>The width of the motif. Each motif describes a pattern of a fixed + width, as no gaps are allowed in MEME motifs.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_more"> + <p>Click on the blue symbol below to reveal more information about this motif.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_submit_dl"> + <p>Click on the blue symbol below to reveal options allowing you + to submit this motif to another MEME Suite motif analysis program, to download this + motif in various text formats, or to download a sequence "logo" of + this motif PNG or EPS format.</p> + <h5>Supported Programs</h5> + <dl> + <dt>Tomtom</dt> + <dd>Tomtom is a tool for searching for similar known motifs. + [<a href="http://meme-suite.org/doc/tomtom.html?man_type=web">manual</a>]</dd> + <dt>MAST</dt> + <dd>MAST is a tool for searching biological sequence databases for + sequences that contain one or more of a group of known motifs. + [<a href="http://meme-suite.org/doc/mast.html?man_type=web">manual</a>]</dd> + <dt>FIMO</dt> + <dd>FIMO is a tool for searching biological sequence databases for + sequences that contain one or more known motifs. + [<a href="http://meme-suite.org/doc/fimo.html?man_type=web">manual</a>]</dd> + <dt>GOMO</dt> + <dd>GOMO is a tool for identifying possible roles (Gene Ontology + terms) for DNA binding motifs. + [<a href="http://meme-suite.org/doc/gomo.html?man_type=web">manual</a>]</dd> + <dt>SpaMo</dt> + <dd>SpaMo is a tool for inferring possible transcription factor + complexes by finding motifs with enriched spacings. + [<a href="http://meme-suite.org/doc/spamo.html?man_type=web">manual</a>]</dd> + </dl> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_llr"> + <p>The log likelihood ratio of the motif.The log likelihood ratio is the + logarithm of the ratio of the probability of the occurrences of the motif + given the motif model (likelihood given the motif) versus their + probability given the background model (likelihood given the null model). + (Normally the background model is a 0-order Markov model using the + background letter frequencies, but higher order Markov models may be + specified via the -bfile option to MEME.).</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_ic"> + <p>The information content of the motif in bits. It is equal to the sum + of the uncorrected information content, R(), in the columns of the pwm. + This is equal relative entropy of the motif relative to a uniform + background frequency model.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_re"> + <p>The relative entropy of the motif.</p> + + <p style="font-family: monospace;">re = llr / (sites * ln(2))</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_bt"> + <p>The Bayes Threshold.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_site_strand"> + <p>The strand used for the motif site.</p> + <dl> + <dt>+</dt> + <dd>The motif site was found in the sequence as it was supplied.</dd> + <dt>-</dt> + <dd>The motif site was found in the reverse complement of the supplied sequence.</dd> + </dl> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_site_start"> + <p>The position in the sequence where the motif site starts. If a motif + started right at the begining of a sequence it would be described as + starting at position 1.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_site_pvalue"> + <p>The probability that an equal or better site would be found in a + random sequence of the same length conforming to the background letter + frequencies.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_site_match"> + <p>A motif site with the 10 flanking letters on either side.</p> + <p>When the site is not on the given strand then the site + and both flanks are reverse complemented so they align.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + + <div class="pop_content" id="pop_seq_name"> + <p>The name of the sequences as given in the FASTA file.</p> + <p>The number to the left of the sequence name is the ordinal + of the sequence.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + + <div class="pop_content" id="pop_motif_sites"> + <p>These are the motif sites predicted by MEME and used to build the motif.</p> + <p>These sites are shown in solid color and hovering the cursor + over a site will reveal details about the site. Only sequences + that contain a motif site are shown.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + + <div class="pop_content" id="pop_scanned_sites"> + <p>These are the motif sites predicted by MEME plus + any additional sites detected using a motif scanning + algorithm.</p> + <p>These MEME sites are shown in solid color and + additional scanned sites are shown in transparent color. + Hovering the cursor over a site will reveal details about the site. + Only sequences containing a predicted or scanned motif site are shown.</p> + <p>The scanned sites are predicted using a + log-odds scoring matrix constructed from the MEME sites. + Only scanned sites with position <i>p</i>-values less + than 0.0001 are shown.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + + <div class="pop_content" id="pop_all_sequences"> + <p>These are the same sites as shown by selecting the + "Motif Sites + Scanned Sites" button except that all + sequences, including those with no sites, are included + in the diagram.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + + <div class="pop_content" id="pop_seq_pvalue"> + <p>This is the combined match <i>p</i>-value.</p> + <p>The combined match <i>p</i>-value is defined as the probability that a + random sequence (with the same length and conforming to the background) + would have position <i>p</i>-values such that the product is smaller + or equal to the value calulated for the sequence under test.</p> + <p>The position <i>p</i>-value is defined as the probability that a + random sequence (with the same length and conforming to the background) + would have a match to the motif under test with a score greater or equal + to the largest found in the sequence under test.</p> + <p>Hovering your mouse over a motif site in the motif location + block diagram will show its position <i>p</i>-value and other information + about the site.</p> + + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_motif_location"> + <p>This diagram shows the location of motif sites.</p> + <p>Each block shows the position and strength of a motif + site. The height of a block gives an indication of the + significance of the site as taller blocks are more significant. + The height is calculated to be proportional to the negative + logarithm of the <i>p</i>-value of the site, truncated at + the height for a <i>p</i>-value of 1e-10.</p> + <p>For complementable alphabets (like DNA), sites on the + positive strand are shown above the line, + sites on the negative strand are shown below.</p> + <p>Placing the cursor + over a motif site will reveal more information about the site + including its position <i>p</i>-value. (See the help + for the <i>p</i>-value column for an explanation of position + <i>p</i>-values.)</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + + <div class="pop_content" id="pop_seq_source"> + <p>The name of the file of sequences input to MEME.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_psp_source"> + <p>The position specific priors file used by MEME to find the motifs.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_seq_alph"> + <p>The alphabet used by the sequences.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_seq_count"> + <p>The number of sequences provided as input to MEME.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + + <div class="pop_content" id="pop_alph_name"> + <p>The name of the alphabet symbol.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_alph_freq"> + <p>The frequency of the alphabet symbol in the dataset with a pseudocount + so it is never zero.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + <div class="pop_content" id="pop_alph_bg"> + <p>The frequency of the alphabet symbol as defined by the background model.</p> + <div style="float:right; bottom:0px;">[ + <a href="javascript:help_popup()">close</a> ]</div> + </div> + + <!-- templates --> + <div id="measure_match" class="match"></div> + <div class="template pop_block" id="tmpl_block_info"> + <div> + <span class="tvar_logo_pad lflank" style="visibility:hidden;"></span> + <span class="tvar_logo"></span> + </div> + <div class="block_sequence_fragment"> + <span class="tvar_lflank lflank"></span> + <span class="tvar_match match"></span> + <span class="tvar_rflank rflank"></span> + </div> + <table class="block_information"> + <tr><th>Motif</th><td class="tvar_motif">1</td></tr> + <tr><th><i>p</i>-value</th><td class="tvar_pvalue">8.23e-7</td></tr> + <tr><th>Start</th><td class="tvar_start">23</td></tr> + <tr><th>End</th><td class="tvar_end">33</td></tr> + </table> + </div> + + <div class="template pop_block" id="tmpl_scan_info"> + <h5>Scanned Site</h5> + <div class="tvar_logo"></div> + <table class="block_information"> + <tr><th>Motif</th><td class="tvar_motif">1</td></tr> + <tr><th><i>p</i>-value</th><td class="tvar_pvalue">8.23e-7</td></tr> + <tr><th>Start</th><td class="tvar_start">23</td></tr> + <tr><th>End</th><td class="tvar_end">33</td></tr> + </table> + </div> + + <div class="template box expanded_motif" id="tmpl_motif_expanded"> + <div style="position: relative; min-height: 20px"> + <div class="param_box"> + <span class="param"><span class="tvar_ordinal"></span>.</span> + </div> + <div class="sym_btn positioned tvar_less" tabindex="0" + title="Show less information.">↥</div> + <div class="sym_btn positioned tvar_submit" tabindex="0" + title="Submit the motif to another MEME Suite program or download it.">⇢</div> + </div> + <div> + <div class="param_box"> + <span class="param"><i>E</i>-value:</span> + <span class="tvar_evalue"></span> + <div class="help" data-topic="pop_ev"></div> + </div> + <div class="param_box"> + <span class="param">Site Count:</span> + <span class="tvar_site_count"></span> + <div class="help" data-topic="pop_sites"></div> + </div> + <div class="param_box"> + <span class="param">Width:</span> + <span class="tvar_width"></span> + <div class="help" data-topic="pop_width"></div> + </div> + </div> + <div class="tabMain base"> + <div class="tabCenter tvar_logo"></div> + </div> + <div class="tabArea base"> + <span class="tvar_tab tab" tabindex="0">Standard</span><span + class="tvar_tab_rc tab middle" tabindex="0">Reverse + Complement</span> + </div> + <div style="padding: 10px 0"> + <div class="param_box"> + <span class="param">Log Likelihood Ratio:</span> + <span class="tvar_llr"></span> + <div class="help" data-topic="pop_llr"></div> + </div> + <div class="param_box"> + <span class="param">Information Content:</span> + <span class="tvar_ic"></span> + <div class="help" data-topic="pop_ic"></div> + </div> + <div class="param_box"> + <span class="param">Relative Entropy:</span> + <span class="tvar_re"></span> + <div class="help" data-topic="pop_re"></div> + </div> + <div class="param_box"> + <span class="param">Bayes Threshold:</span> + <span class="tvar_bt"></span> + <div class="help" data-topic="pop_bt"></div> + </div> + </div> + <div class="tvar_sites"></div> + </div> + + + <div class="popup_wrapper"> + <div class="popup" style="display:none; top: -150px;" id="download"> + <div> + <div style="float:right; "> + <div id="outpop_close" class="close" tabindex="0">x</div> + </div> + <h2 class="mainh" style="margin:0; padding:0;">Submit or Download</h2> + <div style="clear:both"></div> + </div> + <div style="height:100px"> + <div style="float:right; width: 30px;"> + <div id="outpop_prev" class="navarrow" tabindex="0"> + <span class="inactive">⇧</span><span class="active">⬆</span> + </div> + <div id="outpop_num" class="navnum"></div> + <div id="outpop_next" class="navarrow" tabindex="0"> + <span class="inactive">⇩</span><span class="active">⬇</span> + </div> + </div> + <div id="logo_box" style="height: 100px; margin-right: 40px;"> + <canvas id="outpop_logo" height="100" width="580"></canvas> + <canvas id="outpop_logo_rc" class="logo_rc" height="100" width="580"></canvas> + </div> + </div> + <div> + <!-- tabs start --> + <div class="tabArea top"> + <span id="outpop_tab_1" class="tab">Submit Motif</span><span + id="outpop_tab_2" class="tab middle">Download Motif</span><span + id="outpop_tab_3" class="tab middle">Download Logo</span> + </div> + <div class="tabMain top"> + <!-- Submit to another program --> + <div id="outpop_pnl_1"> + <h4 class="compact">Submit to program</h4> + <table id="programs" class="programs"> + <tr class="dna_only"> + <td><input type="radio" name="program" value="tomtom" id="submit_tomtom"></td> + <td><label for="submit_tomtom">Tomtom</label></td> + <td><label for="submit_tomtom">Find similar motifs in + published libraries or a library you supply.</label></td> + </tr> + <tr> + <td><input type="radio" name="program" value="fimo" id="submit_fimo"></td> + <td><label for="submit_fimo">FIMO</label></td> + <td><label for="submit_fimo">Find motif occurrences in + sequence data.</label></td> + </tr> + <tr> + <td><input type="radio" name="program" value="mast" id="submit_mast"></td> + <td><label for="submit_mast">MAST</label></td> + <td><label for="submit_mast">Rank sequences by affinity to + groups of motifs.</label></td> + </tr> + <tr class="dna_only"> + <td><input type="radio" name="program" value="gomo" id="submit_gomo"></td> + <td><label for="submit_gomo">GOMo</label></td> + <td><label for="submit_gomo">Identify possible roles (Gene + Ontology terms) for motifs.</label></td> + </tr> + <tr class="dna_only"> + <td><input type="radio" name="program" value="spamo" id="submit_spamo"></td> + <td><label for="submit_spamo">SpaMo</label></td> + <td><label for="submit_spamo">Find other motifs that are + enriched at specific close spacings which might imply the existance of a complex.</label></td> + </tr> + </table> + </div> + <!-- download text format --> + <div id="outpop_pnl_2"> + <div> + <label for="text_format">Format:</label> + <select id="text_format"> + <option value="0">Count Matrix</option> + <option value="1">Probability Matrix</option> + <option value="2">Minimal MEME</option> + <option value="3">FASTA</option> + <option value="4">Raw</option> + </select> + </div> + <form id="text_form" method="post" action=""> + <script>$("text_form").action = site_url + "/utilities/save_generated_file";</script> + <input type="hidden" id="text_name" name="name" value="motif.txt"> + <input type="hidden" name="mime_type" value="text/plain"> + <textarea id="outpop_text" name="content" + style="width:99%; white-space: pre; word-wrap: normal; overflow-x: scroll;" + rows="8" readonly="readonly" wrap="off"></textarea> + </form> + </div> + <!-- download logo format --> + <div id="outpop_pnl_3"> + <form id="logo_form" method="post" action=""> + <script>$("logo_form").action = site_url + "/utilities/generate_logo";</script> + <input type="hidden" name="program" value="MEME"/> + <input type="hidden" id="logo_motifs" name="motifs" value=""/> + <table> + <tr> + <td><label for="logo_format">Format:</label></td> + <td> + <select id="logo_format" name="png"> + <option value="1">PNG (for web)</option> + <option value="0">EPS (for publication)</option> + </select> + </td> + </tr> + <tr> + <td><label for="logo_rc">Orientation:</label></td> + <td> + <select id="logo_rc" name="rc1"> + <option value="0">Normal</option> + <option value="1" id="logo_rc_option">Reverse Complement</option> + </select> + </td> + </tr> + <tr> + <td><label for="logo_ssc">Small Sample Correction:</label></td> + <td> + <input type="hidden" id="logo_err" name="errbars" value="0"/> + <select id="logo_ssc" name="ssc"> + <option value="0">Off</option> + <option value="1">On</option> + </select> + </td> + </tr> + <tr> + <td><label for="logo_width">Width:</label></td> + <td> + <input type="text" id="logo_width" size="4" placeholder="default" name="width"/> cm + </td> + </tr> + <tr> + <td><label for="logo_height">Height:</label></td> + <td> + <input type="text" id="logo_height" size="4" placeholder="default" name="height"/> cm + </td> + </tr> + </table> + </form> + </div> + <!-- Buttons --> + <div> + <div style="float:left;"> + <input type="button" id="outpop_do" value="Submit" /> + </div> + <div style="float:right;"> + <input id="outpop_cancel" type="button" value="Cancel" /> + </div> + <div style="clear:both;"></div> + </div> + </div> + </div> + </div> + </div> + + + + <!-- Page starts here --> + <div id="top" class="pad1"> + <div class="prog_logo big"> + <img src="data:image/png;base64,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" alt="MEME Logo"> + <h1>MEME</h1> + <h2>Multiple Em for Motif Elicitation</h2> + </div> + <p> + For further information on how to interpret these results or to get a + copy of the MEME software please access + <a href="http://meme-suite.org/">http://meme-suite.org</a>. + </p> + <p>If you use MEME in your research, please cite the following paper:<br /> + <span class="citation"> + Timothy L. Bailey and Charles Elkan, + "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", + <em>Proceedings of the Second International Conference on Intelligent Systems + for Molecular Biology</em>, pp. 28-36, AAAI Press, Menlo Park, California, 1994. + <a href="http://meme-suite.org/doc/ismb94.pdf">[pdf]</a> + </span> + </p> + </div> + <!-- navigation --> + <div class="pad2"> + <a class="jump" href="#motifs_sec">Discovered Motifs</a> + | + <a class="jump" href="#sites_sec">Motif Locations</a> + | + <a class="jump" href="#inputs_sec">Inputs & Settings</a> + | + <a class="jump" href="#info_sec">Program information</a> + </div> + <!-- alert the user when their browser is not up to the task --> + <noscript><h1 style="color:red">Javascript is required to view these results!</h1></noscript> + <h1 id="html5_warning" style="color:red; display:none;">Your browser does not support canvas!</h1> + <script> + if (!window.HTMLCanvasElement) $("html5_warning").style.display = "block"; + </script> + <h2 class="mainh pad2" id="motifs_sec">Discovered Motifs</h2> + <div id="motifs" class="box"> + <p>Please wait... Loading...</p> + <p>If the page has fully loaded and this message does not disappear then an error may have occurred.</p> + </div> + <h2 class="mainh pad2" id="sites_sec">Motif Locations</h2> + <div id="blocks" class="box"> + <p>Please wait... Loading...</p> + <p>If the page has fully loaded and this message does not disappear then an error may have occurred.</p> + </div> + <h2 class="mainh pad2" id="inputs_sec">Inputs & Settings</h2> + <div class="box"> + <h4>Sequences</h4> + <table id="seq_info" class="inputs"> + <tr><th>Source <div class="help" data-topic="pop_seq_source"></div></th> + <th class="col_psp">PSP Source <div class="help" data-topic="pop_psp_source"></div></th> + <th>Alphabet <div class="help" data-topic="pop_seq_alph"></div></th> + <th>Sequence Count <div class="help" data-topic="pop_seq_count"></div></th> + </tr> + <tr> + <td id="ins_seq_source"></td> + <td id="ins_seq_psp" class="col_psp"></td> + <td id="ins_seq_alphabet"></td> + <td id="ins_seq_count"></td> + </tr> + </table> + <script> + { + var db = data.sequence_db; + $("ins_seq_source").innerHTML = db.source; + $("ins_seq_alphabet").innerHTML = meme_alphabet.get_alphabet_name(); + $("ins_seq_count").innerHTML = db.sequences.length; + if (db.psp) { + $("ins_seq_psp").innerHTML = db.psp; + } + toggle_class($("seq_info"), "hide_psp", !(db.psp)); + } + </script> + <h4>Background</h4> + <span id="alpha_bg"></span> + <script> + { + $("alpha_bg").appendChild(make_alpha_bg_table(meme_alphabet, data.sequence_db.freqs)); + } + </script> + <h4>Other Settings</h4> + <table id="tbl_settings" class="inputs hide_advanced"> + <tr> + <th>Motif Site Distribution</th> + <td id="opt_mod"> + <span class="mod_zoops">ZOOPS: Zero or one site per sequence</span> + <span class="mod_oops">OOPS: Exactly one site per sequence</span> + <span class="mod_anr">ANR: Any number of sites per sequence</span> + </td> + </tr> + <tr> + <th>Site Strand Handling</th> + <td id="opt_strand"> + <span class="strand_none">This alphabet only has one strand</span> + <span class="strand_given">Sites must be on the given strand</span> + <span class="strand_both">Sites may be on either strand</span> + </td> + </tr> + <tr> + <th>Maximum Number of Motifs</th> + <td id="opt_nmotifs"></td> + </tr> + <tr> + <th>Motif E-value Threshold</th> + <td id="opt_evt"></td> + </tr> + <tr> + <th>Minimum Motif Width</th> + <td id="opt_minw"></td> + </tr> + <tr> + <th>Maximum Motif Width</th> + <td id="opt_maxw"></td> + </tr> + <tr> + <th>Minimum Sites per Motif</th> + <td id="opt_minsites"></td> + </tr> + <tr> + <th>Maximum Sites per Motif</th> + <td id="opt_maxsites"></td> + </tr> + <tr class="advanced"> + <th>Bias on Number of Sites</th> + <td id="opt_wnsites"></td> + </tr> + <tr class="advanced"> + <th>Sequence Prior</th> + <td id="opt_prior"> + <span class="prior_dirichlet">Simple Dirichlet</span> + <span class="prior_dmix">Dirichlets Mix</span> + <span class="prior_mega">Mega-weight Dirichlets Mix</span> + <span class="prior_megap">Mega-weight Dirichlets Mix Plus</span> + <span class="prior_addone">Add One</span> + </td> + </tr> + <tr class="advanced"> + <th>Sequence Prior Strength</th> + <td id="opt_b"></td> + </tr> + <tr class="advanced"> + <th>EM Starting Point Source</th> + <td id="opt_substring"> + <span class="substring_on">From substrings in input sequences</span> + <span class="substring_off">From strings on command line (-cons)</span> + </td> + </tr> + <tr class="advanced"> + <th>EM Starting Point Map Type</th> + <td id="opt_spmap"> + <span class="spmap_uni">Uniform</span> + <span class="spmap_pam">Point Accepted Mutation</span> + </td> + </tr> + <tr class="advanced"> + <th>EM Starting Point Fuzz</th> + <td id="opt_spfuzz"></td> + </tr> + <tr class="advanced"> + <th>EM Maximum Iterations</th> + <td id="opt_maxiter"></td> + </tr> + <tr class="advanced"> + <th>EM Improvement Threshold</th> + <td id="opt_distance"></td> + </tr> + <tr class="advanced"> + <th>Trim Gap Open Cost</th> + <td id="opt_wg"></td> + </tr> + <tr class="advanced"> + <th>Trim Gap Extend Cost</th> + <td id="opt_ws"></td> + </tr> + <tr class="advanced"> + <th>End Gap Treatment</th> + <td id="opt_noendgaps"> + <span class="noendgaps_on">No cost</span> + <span class="noendgaps_off">Same cost as other gaps</span> + </td> + </tr> + <tr> + <td colspan="2" style="text-align: center"> + <a href="javascript:toggle_class(document.getElementById('tbl_settings'), 'hide_advanced')"> + <span class="show_more">Show Advanced Settings</span> + <span class="show_less">Hide Advanced Settings</span> + </a> + </td> + </tr> + </table> + <script> + { + $("opt_mod").className = data.options.mod; + $("opt_strand").className = (meme_alphabet.has_complement() ? (data.options.revcomp ? "both" : "given") : "none"); + $("opt_nmotifs").textContent = data.options.nmotifs; + $("opt_evt").textContent = (typeof data.options.evt === "number" ? data.options.evt : "no limit"); + $("opt_minw").textContent = data.options.minw; + $("opt_maxw").textContent = data.options.maxw; + $("opt_minsites").textContent = data.options.minsites; + $("opt_maxsites").textContent = data.options.maxsites; + $("opt_wnsites").textContent = data.options.wnsites; + $("opt_spmap").className = data.options.spmap; + $("opt_spfuzz").textContent = data.options.spfuzz; + $("opt_prior").className = data.options.prior; + $("opt_b").textContent = data.options.b; + $("opt_maxiter").textContent = data.options.maxiter; + $("opt_distance").textContent = data.options.distance; + $("opt_wg").textContent = data.options.wg; + $("opt_ws").textContent = data.options.ws; + $("opt_noendgaps").className = (data.options.noendgaps ? "on" : "off"); + $("opt_substring").className = (data.options.substring ? "on" : "off"); + } + </script> + </div> + <!-- list information on this program --> + <div id="info_sec" class="bar"> + <div class="subsection"> + <h5 id="version">MEME version</h5> + <span id="ins_version"></span> + (Release date: <span id="ins_release"></span>)<br> + </div> + <script> + $("ins_version").innerHTML = data["version"]; + $("ins_release").innerHTML = data["release"]; + </script> + <div class="subsection"> + <h5 id="reference">Reference</h5> + <span class="citation"> + Timothy L. Bailey and Charles Elkan, + "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", + <em>Proceedings of the Second International Conference on Intelligent Systems + for Molecular Biology</em>, pp. 28-36, AAAI Press, Menlo Park, California, 1994. + </span> + </div> + <div class="subsection"> + <h5 id="command">Command line</h5> + <textarea id="cmd" rows="5" style="width:100%;" readonly="readonly"> + </textarea> + <script>$("cmd").value = data["cmd"].join(" ");</script> + </div> + </div> + + </body> +</html>