annotate test-data/pre_cco_core.obo @ 0:fc4edae65b37 draft default tip

planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/onto-toolkit commit 9422f839ae354d4c26b02d4494abdeaad518d0e6

format-version: 1.2
date: 16:02:2007 16:06
default-namespace: CCO
autogenerated-by: ONTO-PERL
remark: The Cell-Cycle Ontology

[Term]
id: CCO:B0000000
name: core cell cycle protein
def: "A protein being considered as principal in the regulation of the cell cycle process" [CCO:cco_team]
is_a: CCO:U0000005 ! protein

[Term]
id: CCO:P0000001
name: mitotic spindle elongation
def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah]
is_a: CCO:P0000310 ! spindle elongation
relationship: part_of CCO:P0000058 ! mitotic spindle organization and biogenesis
synonym: "spindle elongation during mitosis" EXACT []
xref: GO:0000022

[Term]
id: CCO:P0000002
name: mitotic sister chromatid segregation
def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000069 ! mitosis
synonym: "mitotic chromosome segregation" EXACT []
synonym: "mitotic sister-chromatid adhesion release" NARROW []
xref: GO:0000070
xref: GO:0016359

[Term]
id: CCO:P0000003
name: M phase specific microtubule process
def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah]
relationship: part_of CCO:P0000038 ! M phase
synonym: "M-phase specific microtubule process" EXACT []
xref: GO:0000072

[Term]
id: CCO:P0000004
name: regulation of progression through cell cycle
def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:go_curators]
is_a: CCO:P0000294 ! regulation of cell cycle
synonym: "cell cycle regulator" RELATED []
synonym: "RHEB small monomeric GTPase activity" RELATED []
synonym: "tumor suppressor" RELATED []
synonym: "control of cell cycle progression" EXACT []
synonym: "modulation of cell cycle progression" EXACT []
synonym: "regulation of cell cycle progression" EXACT []
xref: Reactome:156678
xref: Reactome:156699
xref: Reactome:156711
xref: Reactome:162657
xref: Reactome:165167
xref: Reactome:167104
xref: Reactome:167109
xref: Reactome:169311
xref: Reactome:171117
xref: Reactome:171122
xref: Reactome:174455
xref: Reactome:177752
xref: Reactome:177757
xref: GO:0000074

[Term]
id: CCO:P0000005
name: cell cycle checkpoint
def: "A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, ISBN:0815316194]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
xref: Reactome:69620
xref: GO:0000075

[Term]
id: CCO:P0000006
name: DNA replication checkpoint
def: "A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:rn, PMID:11728327, PMID:12537518]
is_a: CCO:P0000157 ! DNA integrity checkpoint
xref: GO:0000076

[Term]
id: CCO:P0000007
name: DNA damage checkpoint
def: "A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds." [PMID:11891124]
is_a: CCO:P0000157 ! DNA integrity checkpoint
synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW []
xref: GO:0000077

[Term]
id: CCO:P0000008
name: cell morphogenesis checkpoint
def: "A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective." [GOC:vw, PMID:14644188]
is_a: CCO:P0000005 ! cell cycle checkpoint
xref: GO:0000078

[Term]
id: CCO:P0000009
name: regulation of cyclin-dependent protein kinase activity
def: "Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
synonym: "regulation of CDK activity" EXACT []
xref: GO:0000079

[Term]
id: CCO:P0000010
name: G1 phase of mitotic cell cycle
def: "Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis." [ISBN:0815316194]
is_a: CCO:P0000262 ! G1 phase
relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
xref: Reactome:69236
xref: GO:0000080

[Term]
id: CCO:P0000011
name: G1/S transition of mitotic cell cycle
def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
xref: Reactome:69206
xref: GO:0000082

[Term]
id: CCO:P0000012
name: G1/S-specific transcription in mitotic cell cycle
def: "Any process that regulates transcription such that the target genes are transcribed during the G1/S phase of the mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000011 ! G1/S transition of mitotic cell cycle
xref: Reactome:69205
xref: GO:0000083

[Term]
id: CCO:P0000013
name: S phase of mitotic cell cycle
def: "Progression through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place." [ISBN:0815316194]
is_a: CCO:P0000264 ! S phase
relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
xref: GO:0000084

[Term]
id: CCO:P0000014
name: G2 phase of mitotic cell cycle
def: "Progression through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis." [ISBN:0815316194]
is_a: CCO:P0000263 ! G2 phase
relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
xref: Reactome:68911
xref: GO:0000085

[Term]
id: CCO:P0000015
name: G2/M transition of mitotic cell cycle
def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
xref: Reactome:69275
xref: GO:0000086

[Term]
id: CCO:P0000016
name: M phase of mitotic cell cycle
def: "Progression through M phase, the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:mah, ISBN:0815316194]
is_a: CCO:P0000038 ! M phase
relationship: part_of CCO:P0000037 ! mitotic cell cycle
synonym: "M-phase of mitotic cell cycle" EXACT []
xref: Reactome:68886
xref: GO:0000087

[Term]
id: CCO:P0000017
name: mitotic prophase
def: "Progression through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle." [ISBN:0815316194]
is_a: CCO:P0000268 ! prophase
relationship: part_of CCO:P0000069 ! mitosis
xref: Reactome:68875
xref: GO:0000088

[Term]
id: CCO:P0000018
name: mitotic metaphase
def: "Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles." [ISBN:0815316194]
is_a: CCO:P0000267 ! metaphase
relationship: part_of CCO:P0000069 ! mitosis
xref: Reactome:68879
xref: GO:0000089

[Term]
id: CCO:P0000019
name: mitotic anaphase
def: "Progression through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [ISBN:0815316194]
is_a: CCO:P0000266 ! anaphase
relationship: part_of CCO:P0000069 ! mitosis
xref: Reactome:68882
xref: GO:0000090

[Term]
id: CCO:P0000020
name: mitotic anaphase A
def: "Progression through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [ISBN:0815316194]
is_a: CCO:P0000019 ! mitotic anaphase
xref: GO:0000091

[Term]
id: CCO:P0000021
name: mitotic anaphase B
def: "Progression through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [ISBN:0815316194]
is_a: CCO:P0000019 ! mitotic anaphase
xref: GO:0000092

[Term]
id: CCO:P0000022
name: mitotic telophase
def: "Progression through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [ISBN:0721662544]
is_a: CCO:P0000270 ! telophase
relationship: part_of CCO:P0000069 ! mitosis
xref: GO:0000093

[Term]
id: CCO:P0000023
name: G1-specific transcription in mitotic cell cycle
def: "Any process that regulates transcription such that the target genes are transcribed during the G1 phase of the mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000010 ! G1 phase of mitotic cell cycle
xref: GO:0000114

[Term]
id: CCO:P0000024
name: S-phase-specific transcription in mitotic cell cycle
def: "A cell cycle process that regulates transcription such that the target genes are transcribed during the S phase of the mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000013 ! S phase of mitotic cell cycle
synonym: "S-specific transcription in mitotic cell cycle" EXACT []
xref: Reactome:69241
xref: GO:0000115

[Term]
id: CCO:P0000025
name: G2-specific transcription in mitotic cell cycle
def: "Any process that regulates transcription such that the target genes are transcribed during the G2 phase of the mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000014 ! G2 phase of mitotic cell cycle
xref: GO:0000116

[Term]
id: CCO:P0000026
name: G2/M-specific transcription in mitotic cell cycle
def: "Any process that regulates transcription such that the target genes are transcribed during the G2/M phase of the mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000015 ! G2/M transition of mitotic cell cycle
xref: Reactome:69274
xref: GO:0000117

[Term]
id: CCO:P0000027
name: establishment of mitotic spindle orientation
def: "The processes that set the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
is_a: CCO:P0000177 ! establishment of mitotic spindle localization
synonym: "establishment of spindle orientation during mitosis" EXACT []
synonym: "mitotic spindle orientation" EXACT []
synonym: "orienting of mitotic spindle" EXACT []
synonym: "mitotic spindle orientation (sensu Fungi)" NARROW []
synonym: "mitotic spindle orientation (sensu Saccharomyces)" NARROW []
xref: GO:0000132
xref: GO:0030607
xref: GO:0030609

[Term]
id: CCO:P0000028
name: septin checkpoint
def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642]
is_a: CCO:P0000005 ! cell cycle checkpoint
xref: GO:0000135

[Term]
id: CCO:P0000029
name: meiotic spindle organization and biogenesis
def: "The cell cycle process whereby the microtubule spindle is formed and maintained during a meiotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000265 ! meiotic cell cycle
synonym: "meiotic spindle organisation and biogenesis" EXACT []
synonym: "spindle organization and biogenesis during meiosis" EXACT []
xref: GO:0000212

[Term]
id: CCO:P0000030
name: M/G1 transition of mitotic cell cycle
def: "Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
xref: Reactome:68874
xref: GO:0000216

[Term]
id: CCO:P0000031
name: mitotic prometaphase
def: "Progression through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mah, ISBN:0198547684]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000069 ! mitosis
xref: Reactome:68877
xref: GO:0000236

[Term]
id: CCO:P0000032
name: leptotene
def: "Progression through the first stage of prophase I in meiosis, in which chromosomes first become visible." [ISBN:0198547684]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000105 ! meiotic prophase I
xref: GO:0000237

[Term]
id: CCO:P0000033
name: zygotene
def: "Progression through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [ISBN:0198547684]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000105 ! meiotic prophase I
xref: GO:0000238

[Term]
id: CCO:P0000034
name: pachytene
def: "Progression through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [ISBN:0198547684]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000105 ! meiotic prophase I
xref: GO:0000239

[Term]
id: CCO:P0000035
name: diplotene
def: "Progression through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [ISBN:0198547684]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000105 ! meiotic prophase I
xref: GO:0000240

[Term]
id: CCO:P0000036
name: diakinesis
def: "Progression through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [ISBN:0198547684]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000105 ! meiotic prophase I
xref: GO:0000241

[Term]
id: CCO:P0000037
name: mitotic cell cycle
def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M." [GOC:mah, ISBN:0815316194]
is_a: CCO:P0000056 ! cell cycle
xref: Reactome:69278
xref: GO:0000278

[Term]
id: CCO:P0000038
name: M phase
def: "Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis." [ISBN:0815316194]
is_a: CCO:P0000309 ! cell cycle phase
synonym: "M-phase" EXACT []
xref: GO:0000279

[Term]
id: CCO:P0000039
name: cytokinesis after mitosis
def: "The processes resulting in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000016 ! M phase of mitotic cell cycle
xref: GO:0000281

[Term]
id: CCO:P0000040
name: re-entry into mitotic cell cycle
def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
xref: GO:0000320

[Term]
id: CCO:P0000041
name: re-entry into mitotic cell cycle after pheromone arrest
def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449]
is_a: CCO:P0000040 ! re-entry into mitotic cell cycle
synonym: "re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)" NARROW []
xref: GO:0000321

[Term]
id: CCO:P0000042
name: achiasmate meiosis I
def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419]
is_a: CCO:P0000104 ! meiosis I
xref: GO:0000705

[Term]
id: CCO:P0000043
name: meiotic DNA double-strand break processing
def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000054 ! meiotic gene conversion
relationship: part_of CCO:P0000108 ! meiotic recombination
xref: GO:0000706

[Term]
id: CCO:P0000044
name: meiotic DNA recombinase assembly
def: "During meiosis, the assembly of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000054 ! meiotic gene conversion
relationship: part_of CCO:P0000108 ! meiotic recombination
xref: GO:0000707

[Term]
id: CCO:P0000045
name: meiotic strand invasion
def: "The cell cycle process whereby the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000054 ! meiotic gene conversion
relationship: part_of CCO:P0000108 ! meiotic recombination
synonym: "meiotic D-loop biosynthesis" RELATED []
synonym: "meiotic D-loop formation" RELATED []
xref: GO:0000708

[Term]
id: CCO:P0000046
name: meiotic joint molecule formation
def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000108 ! meiotic recombination
xref: GO:0000709

[Term]
id: CCO:P0000047
name: meiotic mismatch repair
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000054 ! meiotic gene conversion
relationship: part_of CCO:P0000108 ! meiotic recombination
xref: GO:0000710

[Term]
id: CCO:P0000048
name: meiotic DNA repair synthesis
def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000054 ! meiotic gene conversion
relationship: part_of CCO:P0000108 ! meiotic recombination
xref: GO:0000711

[Term]
id: CCO:P0000049
name: resolution of meiotic joint molecules as recombinants
def: "The cleavage and rejoining of Holliday junctions to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
is_a: CCO:P0000254 ! meiotic chromosome separation
relationship: part_of CCO:P0000108 ! meiotic recombination
relationship: part_of CCO:P0000191 ! homologous chromosome segregation
synonym: "meiotic homologous chromosome separation" RELATED []
synonym: "homologous chromosome separation at meiosis I" EXACT []
synonym: "crossover biosynthesis" NARROW []
synonym: "crossover formation" NARROW []
synonym: "formation of chiasmata" NARROW []
xref: GO:0000712

[Term]
id: CCO:P0000050
name: meiotic heteroduplex formation
def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000054 ! meiotic gene conversion
xref: GO:0000713

[Term]
id: CCO:P0000051
name: meiotic strand displacement
def: "The cell cycle process whereby the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000054 ! meiotic gene conversion
xref: GO:0000714

[Term]
id: CCO:P0000052
name: cell cycle arrest in response to pheromone
def: "The processes that lead to a halt in cell cycle progression (cessation of cell cycle transitions) as a result of a pheromone stimulus." [GOC:clt]
is_a: CCO:P0000057 ! cell cycle arrest
synonym: "cell cycle arrest (sensu Saccharomyces)" RELATED []
xref: GO:0000751
xref: GO:0030571

[Term]
id: CCO:P0000053
name: negative regulation of exit from mitosis
def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn]
is_a: CCO:P0000095 ! regulation of exit from mitosis
synonym: "down regulation of exit from mitosis" EXACT []
synonym: "down-regulation of exit from mitosis" EXACT []
synonym: "downregulation of exit from mitosis" EXACT []
synonym: "inhibition of exit from mitosis" NARROW []
xref: GO:0001100

[Term]
id: CCO:P0000054
name: meiotic gene conversion
def: "The cell cycle process whereby genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000104 ! meiosis I
synonym: "gene conversion without reciprocal crossover" EXACT []
xref: GO:0006311

[Term]
id: CCO:P0000055
name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators]
is_a: CCO:P0000158 ! G1 DNA damage checkpoint
xref: GO:0006977

[Term]
id: CCO:P0000056
name: cell cycle
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]
is_a: CCO:U0000002 ! cell-cycle process
synonym: "cell-division cycle" EXACT []
xref: GO:0007049

[Term]
id: CCO:P0000057
name: cell cycle arrest
def: "Any process by which progression through the cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:mah]
is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
synonym: "arrest of cell cycle progression" EXACT []
synonym: "cessation of cell cycle" EXACT []
synonym: "termination of cell cycle" EXACT []
xref: GO:0007050

[Term]
id: CCO:P0000058
name: mitotic spindle organization and biogenesis
def: "The cell cycle process whereby the microtubule spindle is formed and maintained during a mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000037 ! mitotic cell cycle
synonym: "mitotic spindle organisation and biogenesis" EXACT []
synonym: "spindle organization and biogenesis during mitosis" EXACT []
xref: GO:0007052

[Term]
id: CCO:P0000059
name: male meiotic spindle assembly (sensu Metazoa)
def: "The formation of the spindle during a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
is_a: CCO:P0000242 ! meiotic spindle assembly
relationship: part_of CCO:P0000117 ! male meiosis
xref: GO:0007053

[Term]
id: CCO:P0000060
name: male meiosis I spindle assembly (sensu Metazoa)
def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
is_a: CCO:P0000059 ! male meiotic spindle assembly (sensu Metazoa)
relationship: part_of CCO:P0000118 ! male meiosis I
xref: GO:0007054

[Term]
id: CCO:P0000061
name: male meiosis II spindle assembly (sensu Metazoa)
def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
is_a: CCO:P0000059 ! male meiotic spindle assembly (sensu Metazoa)
relationship: part_of CCO:P0000119 ! male meiosis II
xref: GO:0007055

[Term]
id: CCO:P0000062
name: female meiotic spindle assembly (sensu Metazoa)
def: "The formation of the spindle during a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
is_a: CCO:P0000242 ! meiotic spindle assembly
relationship: part_of CCO:P0000120 ! female meiosis
xref: GO:0007056

[Term]
id: CCO:P0000063
name: female meiosis I spindle assembly (sensu Metazoa)
def: "The formation of the spindle during meiosis I of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
is_a: CCO:P0000062 ! female meiotic spindle assembly (sensu Metazoa)
relationship: part_of CCO:P0000121 ! female meiosis I
xref: GO:0007057

[Term]
id: CCO:P0000064
name: female meiosis II spindle assembly (sensu Metazoa)
def: "The formation of the spindle during meiosis II of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
is_a: CCO:P0000062 ! female meiotic spindle assembly (sensu Metazoa)
relationship: part_of CCO:P0000123 ! female meiosis II
xref: GO:0007058

[Term]
id: CCO:P0000065
name: male meiosis chromosome segregation
def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai]
is_a: CCO:P0000189 ! meiotic chromosome segregation
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000117 ! male meiosis
xref: GO:0007060

[Term]
id: CCO:P0000066
name: mitotic sister chromatid cohesion
def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during mitosis. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
synonym: "mitotic sister-chromatid adhesion release" RELATED []
xref: GO:0007064

[Term]
id: CCO:P0000067
name: male meiosis sister chromatid cohesion
def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai]
is_a: CCO:P0000240 ! meiotic sister chromatid cohesion
relationship: part_of CCO:P0000117 ! male meiosis
xref: GO:0007065

[Term]
id: CCO:P0000068
name: female meiosis sister chromatid cohesion
def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai]
is_a: CCO:P0000240 ! meiotic sister chromatid cohesion
relationship: part_of CCO:P0000120 ! female meiosis
xref: GO:0007066

[Term]
id: CCO:P0000069
name: mitosis
def: "Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:ma, ISBN:0198547684]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000016 ! M phase of mitotic cell cycle
xref: GO:0007067

[Term]
id: CCO:P0000070
name: negative regulation of transcription, mitotic
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
is_a: CCO:P0000206 ! regulation of transcription, mitotic
synonym: "down regulation of transcription, mitotic" EXACT []
synonym: "down-regulation of transcription, mitotic" EXACT []
synonym: "downregulation of transcription, mitotic" EXACT []
synonym: "mitotic repression of transcription" EXACT []
synonym: "inhibition of transcription, mitotic" NARROW []
xref: GO:0007068

[Term]
id: CCO:P0000071
name: negative regulation of transcription from RNA polymerase I promoter, mitotic
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
is_a: CCO:P0000070 ! negative regulation of transcription, mitotic
is_a: CCO:P0000216 ! regulation of transcription from RNA polymerase I promoter, mitotic
synonym: "down regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "down-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "downregulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "mitotic repression of transcription from Pol I promoter" EXACT []
synonym: "negative regulation of transcription from Pol I promoter, mitotic" EXACT []
synonym: "inhibition of transcription from RNA polymerase I promoter, mitotic" NARROW []
xref: GO:0007069

[Term]
id: CCO:P0000072
name: negative regulation of transcription from RNA polymerase II promoter, mitotic
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
is_a: CCO:P0000070 ! negative regulation of transcription, mitotic
is_a: CCO:P0000218 ! regulation of transcription from RNA polymerase II promoter, mitotic
synonym: "down regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "mitotic repression of transcription from Pol II promoter" EXACT []
synonym: "negative regulation of transcription from Pol II promoter, mitotic" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter, mitotic" NARROW []
xref: GO:0007070

[Term]
id: CCO:P0000073
name: negative regulation of transcription from RNA polymerase III promoter, mitotic
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
is_a: CCO:P0000070 ! negative regulation of transcription, mitotic
is_a: CCO:P0000220 ! regulation of transcription from RNA polymerase III promoter, mitotic
synonym: "down regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "down-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "downregulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "mitotic repression of transcription from Pol III promoter" EXACT []
synonym: "negative regulation of transcription from Pol III promoter, mitotic" EXACT []
synonym: "inhibition of transcription from RNA polymerase III promoter, mitotic" NARROW []
xref: GO:0007071

[Term]
id: CCO:P0000074
name: activation of transcription on exit from mitosis
def: "The cell cycle process whereby transcription is positively regulated as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:isa_complete]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000016 ! M phase of mitotic cell cycle
xref: GO:0007072

[Term]
id: CCO:P0000075
name: activation of transcription on exit from mitosis, from RNA polymerase I promoter
is_a: CCO:P0000074 ! activation of transcription on exit from mitosis
synonym: "activation of transcription on exit from mitosis, from Pol I promoter" EXACT []
xref: GO:0007073

[Term]
id: CCO:P0000076
name: activation of transcription on exit from mitosis, from RNA polymerase II promoter
is_a: CCO:P0000074 ! activation of transcription on exit from mitosis
synonym: "activation of transcription on exit from mitosis, from Pol II promoter" EXACT []
xref: GO:0007074

[Term]
id: CCO:P0000077
name: activation of transcription on exit from mitosis, from RNA polymerase III promoter
is_a: CCO:P0000074 ! activation of transcription on exit from mitosis
synonym: "activation of transcription on exit from mitosis, from Pol III promoter" EXACT []
xref: GO:0007075

[Term]
id: CCO:P0000078
name: mitotic chromosome condensation
def: "The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
xref: GO:0007076

[Term]
id: CCO:P0000079
name: mitotic nuclear envelope disassembly
def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000037 ! mitotic cell cycle
synonym: "mitotic nuclear envelope breakdown" EXACT []
synonym: "mitotic nuclear envelope catabolism" EXACT []
synonym: "mitotic nuclear envelope degradation" EXACT []
xref: GO:0007077

[Term]
id: CCO:P0000080
name: lamin depolymerization
def: "The cell cycle process whereby lamin is depolymerized." [GOC:jic]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000079 ! mitotic nuclear envelope disassembly
xref: GO:0007078

[Term]
id: CCO:P0000081
name: mitotic chromosome movement towards spindle pole
def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
synonym: "chromosome migration to spindle pole during mitosis" EXACT []
synonym: "chromosome movement towards spindle pole during mitosis" EXACT []
synonym: "mitotic chromosome movement to spindle pole" EXACT []
synonym: "mitotic sister chromosome movement towards spindle pole" EXACT []
synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT []
synonym: "mitotic chromosome movement" BROAD []
xref: GO:0007079
xref: GO:0007082

[Term]
id: CCO:P0000082
name: mitotic metaphase plate congression
def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
xref: GO:0007080

[Term]
id: CCO:P0000083
name: mitotic chromosome decondensation
def: "The cell cycle process whereby chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
xref: GO:0007083

[Term]
id: CCO:P0000084
name: mitotic nuclear envelope reassembly
def: "The cell cycle process whereby the nuclear envelope reforms during mitotic cell division." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000037 ! mitotic cell cycle
xref: GO:0007084

[Term]
id: CCO:P0000085
name: vesicle fusion with nuclear membrane
def: "The cell cycle process whereby the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus occurs." [GOC:jic]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000084 ! mitotic nuclear envelope reassembly
synonym: "vesicle fusion" BROAD []
xref: GO:0007086

[Term]
id: CCO:P0000086
name: mitotic nuclear pore complex reassembly
def: "The cell cycle process whereby nuclear pore complexes reform during mitotic cell division." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000084 ! mitotic nuclear envelope reassembly
xref: GO:0007087

[Term]
id: CCO:P0000087
name: regulation of mitosis
def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
relationship: part_of CCO:P0000069 ! mitosis
xref: Reactome:73674
xref: GO:0007088

[Term]
id: CCO:P0000088
name: traversing start control point of mitotic cell cycle
def: "Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle." [GOC:mah, ISBN:0815316194]
is_a: CCO:P0000124 ! regulation of progression through mitotic cell cycle
relationship: part_of CCO:P0000010 ! G1 phase of mitotic cell cycle
synonym: "G1 checkpoint" RELATED []
xref: GO:0007089
xref: GO:0000081

[Term]
id: CCO:P0000089
name: regulation of S phase of mitotic cell cycle
def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000013 ! S phase of mitotic cell cycle
relationship: part_of CCO:P0000124 ! regulation of progression through mitotic cell cycle
xref: GO:0007090

[Term]
id: CCO:P0000090
name: mitotic metaphase/anaphase transition
def: "The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins." [PMID:10465783]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000069 ! mitosis
xref: Reactome:68881
xref: GO:0007091

[Term]
id: CCO:P0000091
name: anaphase-promoting complex activation during mitotic cell cycle
def: "Any process that activates, maintains or increases the rate of the ubiquitin ligase activity of the anaphase-promoting complex during the mitotic cell cycle." [GOC:mah, PMID:10871297]
is_a: CCO:P0000282 ! positive regulation of ubiquitin ligase activity during mitotic cell cycle
relationship: part_of CCO:P0000139 ! regulation of mitotic metaphase/anaphase transition
synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during mitotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during mitotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of APC during mitotic cell cycle" EXACT []
synonym: "anaphase promoting complex activation during mitotic cell cycle" EXACT []
synonym: "APC activation during mitotic cell cycle" EXACT []
synonym: "mitotic anaphase promoting complex activation" EXACT []
synonym: "mitotic anaphase-promoting complex activation" EXACT []
synonym: "mitotic APC activation" EXACT []
synonym: "mitotic anaphase promoting complex activator" NARROW []
synonym: "mitotic anaphase-promoting complex activator" NARROW []
synonym: "mitotic APC activator" NARROW []
xref: Reactome:162659
xref: Reactome:163010
xref: Reactome:165237
xref: Reactome:166428
xref: Reactome:169381
xref: Reactome:170447
xref: Reactome:173214
xref: Reactome:173955
xref: Reactome:176216
xref: Reactome:177163
xref: GO:0007092

[Term]
id: CCO:P0000092
name: mitotic checkpoint
def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis." [GOC:rn, PMID:12360190]
is_a: CCO:P0000005 ! cell cycle checkpoint
is_a: CCO:P0000087 ! regulation of mitosis
xref: Reactome:73676
xref: GO:0007093

[Term]
id: CCO:P0000093
name: mitotic spindle checkpoint
def: "A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly)." [GOC:rn, PMID:12360190]
is_a: CCO:P0000092 ! mitotic checkpoint
is_a: CCO:P0000164 ! spindle checkpoint
synonym: "Mad2-dependent checkpoint" NARROW []
xref: Reactome:69618
xref: GO:0007094

[Term]
id: CCO:P0000094
name: mitotic G2 checkpoint
def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA." [GOC:mah, PMID:10856933, PMID:11406266]
is_a: CCO:P0000092 ! mitotic checkpoint
is_a: CCO:P0000159 ! G2/M transition DNA damage checkpoint
synonym: "mitotic G2/M transition DNA damage checkpoint" EXACT []
xref: GO:0007095

[Term]
id: CCO:P0000095
name: regulation of exit from mitosis
def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]
is_a: CCO:P0000087 ! regulation of mitosis
xref: GO:0007096

[Term]
id: CCO:P0000096
name: centrosome cycle
def: "The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
is_a: CCO:P0000308 ! cell cycle process
xref: GO:0007098

[Term]
id: CCO:P0000097
name: centriole replication
def: "The cell cycle process whereby a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kva, ISBN:0815316194]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000251 ! centrosome duplication
synonym: "centriole duplication" EXACT []
xref: GO:0007099

[Term]
id: CCO:P0000098
name: mitotic centrosome separation
def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]
is_a: CCO:P0000252 ! centrosome separation
xref: GO:0007100

[Term]
id: CCO:P0000099
name: male meiosis centrosome cycle
def: "Centrosome duplication and separation in the context of male meiosis." [GOC:mah]
is_a: CCO:P0000096 ! centrosome cycle
xref: GO:0007101

[Term]
id: CCO:P0000100
name: cytokinesis after meiosis I
def: "The processes resulting in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
is_a: CCO:P0000179 ! polar body extrusion after meiotic divisions
xref: GO:0007110

[Term]
id: CCO:P0000101
name: cytokinesis after meiosis II
def: "The processes resulting in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
is_a: CCO:P0000179 ! polar body extrusion after meiotic divisions
xref: GO:0007111

[Term]
id: CCO:P0000102
name: endomitotic cell cycle
def: "The replication and division of chromosomes which is not followed by nuclear division, resulting in an increased number of chromosomes in the cell." [http:www.onelook.com]
is_a: CCO:P0000056 ! cell cycle
synonym: "endomitosis" EXACT []
xref: GO:0007113

[Term]
id: CCO:P0000103
name: meiosis
def: "Progression through meiosis, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiosis occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations." [PMID:9334324]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000271 ! M phase of meiotic cell cycle
xref: GO:0007126

[Term]
id: CCO:P0000104
name: meiosis I
def: "Progression through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [PMID:9334324]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000103 ! meiosis
xref: GO:0007127

[Term]
id: CCO:P0000105
name: meiotic prophase I
def: "Progression through prophase of meiosis I; divided into several stages." [GOC:mah]
is_a: CCO:P0000268 ! prophase
relationship: part_of CCO:P0000104 ! meiosis I
xref: GO:0007128

[Term]
id: CCO:P0000106
name: synapsis
def: "The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate." [GOC:elh]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000104 ! meiosis I
synonym: "homologous chromosome pairing at meiosis" EXACT []
xref: GO:0007129

[Term]
id: CCO:P0000107
name: synaptonemal complex assembly
def: "The cell cycle process whereby the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000106 ! synapsis
synonym: "synaptonemal complex formation" EXACT []
xref: GO:0007130

[Term]
id: CCO:P0000108
name: meiotic recombination
def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000104 ! meiosis I
synonym: "gene conversion with reciprocal crossover" EXACT []
synonym: "female meiotic recombination" NARROW []
xref: GO:0007131
xref: GO:0000021
xref: GO:0007145

[Term]
id: CCO:P0000109
name: meiotic metaphase I
def: "Progression through metaphase of meiosis I; analogous to mitotic metaphase." [GOC:mah]
is_a: CCO:P0000267 ! metaphase
relationship: part_of CCO:P0000104 ! meiosis I
xref: GO:0007132

[Term]
id: CCO:P0000110
name: meiotic anaphase I
def: "Progression through anaphase of meiosis I; analogous to mitotic anaphase." [GOC:mah]
is_a: CCO:P0000266 ! anaphase
relationship: part_of CCO:P0000104 ! meiosis I
xref: GO:0007133

[Term]
id: CCO:P0000111
name: meiotic telophase I
def: "Progression through telophase of meiosis I; analogous to mitotic telophase." [GOC:mah]
is_a: CCO:P0000270 ! telophase
relationship: part_of CCO:P0000104 ! meiosis I
xref: GO:0007134

[Term]
id: CCO:P0000112
name: meiosis II
def: "Progression through the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [ISBN:0198547684]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000103 ! meiosis
xref: GO:0007135

[Term]
id: CCO:P0000113
name: meiotic prophase II
def: "Progression through prophase of meiosis II; analogous to mitotic prophase." [GOC:mah]
is_a: CCO:P0000268 ! prophase
relationship: part_of CCO:P0000112 ! meiosis II
xref: GO:0007136

[Term]
id: CCO:P0000114
name: meiotic metaphase II
def: "Progression through metaphase of meiosis II; analogous to mitotic metaphase." [GOC:mah]
is_a: CCO:P0000267 ! metaphase
relationship: part_of CCO:P0000112 ! meiosis II
xref: GO:0007137

[Term]
id: CCO:P0000115
name: meiotic anaphase II
def: "Progression through anaphase of meiosis II; analogous to mitotic anaphase." [GOC:mah]
is_a: CCO:P0000266 ! anaphase
relationship: part_of CCO:P0000112 ! meiosis II
xref: GO:0007138

[Term]
id: CCO:P0000116
name: meiotic telophase II
def: "Progression through telophase of meiosis II; analogous to mitotic telophase." [GOC:mah]
is_a: CCO:P0000270 ! telophase
relationship: part_of CCO:P0000112 ! meiosis II
xref: GO:0007139

[Term]
id: CCO:P0000117
name: male meiosis
def: "Meiosis in the male germline." [GOC:mah]
is_a: CCO:P0000103 ! meiosis
xref: GO:0007140

[Term]
id: CCO:P0000118
name: male meiosis I
def: "Progression through male meiosis I, the first meiotic division in the male germline." [GOC:mah]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000117 ! male meiosis
xref: GO:0007141

[Term]
id: CCO:P0000119
name: male meiosis II
def: "Progression through male meiosis II, the second meiotic division in the male germline." [GOC:mah]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000117 ! male meiosis
xref: GO:0007142

[Term]
id: CCO:P0000120
name: female meiosis
def: "Meiosis in the female germline." [GOC:ems]
is_a: CCO:P0000103 ! meiosis
comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaprodites such as those of C. elegans. See also the biological process term 'meiosis ; GO:0007126'.
xref: GO:0007143

[Term]
id: CCO:P0000121
name: female meiosis I
def: "The cell cycle process whereby the first meiotic division occurs in the female germline." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000120 ! female meiosis
xref: GO:0007144

[Term]
id: CCO:P0000122
name: meiotic recombination nodule assembly
def: "The assembly of small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324]
is_a: CCO:P0000044 ! meiotic DNA recombinase assembly
xref: GO:0007146

[Term]
id: CCO:P0000123
name: female meiosis II
def: "The cell cycle process whereby the second meiotic division occurs in the female germline." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000120 ! female meiosis
xref: GO:0007147

[Term]
id: CCO:P0000124
name: regulation of progression through mitotic cell cycle
def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
relationship: part_of CCO:P0000037 ! mitotic cell cycle
synonym: "mitotic cell cycle regulator" RELATED []
synonym: "control of mitotic cell cycle progression" EXACT []
synonym: "mitotic cell cycle control" EXACT []
synonym: "mitotic cell cycle modulation" EXACT []
synonym: "mitotic cell cycle regulation" EXACT []
synonym: "modulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of mitotic cell cycle" EXACT []
synonym: "regulation of mitotic cell cycle progression" EXACT []
xref: GO:0007346

[Term]
id: CCO:P0000125
name: regulation of progression through preblastoderm mitotic cell cycle
def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000129 ! regulation of progression through embryonic mitotic cell cycle
relationship: part_of CCO:P0000175 ! preblastoderm mitotic cell cycle
synonym: "preblastoderm mitotic cell cycle regulator" RELATED []
synonym: "control of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "preblastoderm mitotic cell cycle control" EXACT []
synonym: "preblastoderm mitotic cell cycle modulation" EXACT []
synonym: "preblastoderm mitotic cell cycle regulation" EXACT []
synonym: "regulation of preblastoderm mitotic cell cycle" EXACT []
synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT []
xref: GO:0007347

[Term]
id: CCO:P0000126
name: regulation of progression through syncytial blastoderm mitotic cell cycle
def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000129 ! regulation of progression through embryonic mitotic cell cycle
relationship: part_of CCO:P0000176 ! syncytial blastoderm mitotic cell cycle
synonym: "syncytial blastoderm cell cycle regulator" RELATED []
synonym: "control of syncytial blastoderm cell cycle progression" EXACT []
synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "regulation of syncytial blastoderm cell cycle" EXACT []
synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "syncytial blastoderm cell cycle control" EXACT []
synonym: "syncytial blastoderm cell cycle modulation" EXACT []
synonym: "syncytial blastoderm cell cycle regulation" EXACT []
xref: GO:0007348

[Term]
id: CCO:P0000127
name: cyclin catabolic process
def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions." [GOC:mah, http:cancerweb.ncl.ac.uk]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
synonym: "cyclin breakdown" EXACT []
synonym: "cyclin catabolism" EXACT []
synonym: "cyclin degradation" EXACT []
synonym: "degradation of cyclin" EXACT []
xref: GO:0008054

[Term]
id: CCO:P0000128
name: meiotic G2/MI transition
def: "The cell cycle process whereby a cell progresses from meiotic prophase to metaphase I." [PMID:15088480]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000104 ! meiosis I
xref: GO:0008315

[Term]
id: CCO:P0000129
name: regulation of progression through embryonic mitotic cell cycle
def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:go_curators]
is_a: CCO:P0000124 ! regulation of progression through mitotic cell cycle
relationship: part_of CCO:P0000193 ! mitotic cell cycle, embryonic
synonym: "embryonic mitotic cell cycle regulator" RELATED []
synonym: "control of embryonic mitotic cell cycle progression" EXACT []
synonym: "embryonic mitotic cell cycle control" EXACT []
synonym: "embryonic mitotic cell cycle modulation" EXACT []
synonym: "embryonic mitotic cell cycle regulation" EXACT []
synonym: "modulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "regulation of embryonic mitotic cell cycle" EXACT []
synonym: "regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "regulation of mitotic cell cycle, embryonic" EXACT []
xref: GO:0009794

[Term]
id: CCO:P0000130
name: cell plate formation (sensu Magnoliophyta)
def: "The cell cycle process whereby the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:tb, ISBN:0879015322]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000069 ! mitosis
xref: GO:0009920

[Term]
id: CCO:P0000131
name: male meiotic spindle assembly (sensu Viridiplantae)
def: "The formation of the spindle in male meiotic cells. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [PMID:11973272]
is_a: CCO:P0000242 ! meiotic spindle assembly
relationship: part_of CCO:P0000117 ! male meiosis
xref: GO:0009971

[Term]
id: CCO:P0000132
name: female meiosis chromosome segregation
def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
is_a: CCO:P0000189 ! meiotic chromosome segregation
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000120 ! female meiosis
xref: GO:0016321

[Term]
id: CCO:P0000133
name: second mitotic wave (sensu Endopterygota)
def: "A discrete cell cycle that occurs during the third instar eye imaginal disc after progression of the morphogenetic furrow. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392)." [PMID:11257224]
is_a: CCO:P0000056 ! cell cycle
xref: GO:0016330

[Term]
id: CCO:P0000134
name: meiotic chromosome movement towards spindle pole
def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
synonym: "chromosome migration to spindle pole during meiosis" EXACT []
synonym: "chromosome movement towards spindle pole during meiosis" EXACT []
synonym: "meiotic chromosome movement to spindle pole" EXACT []
synonym: "meiotic chromosome movement" BROAD []
xref: GO:0016344

[Term]
id: CCO:P0000135
name: female meiotic chromosome movement towards spindle pole
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai]
is_a: CCO:P0000134 ! meiotic chromosome movement towards spindle pole
relationship: part_of CCO:P0000132 ! female meiosis chromosome segregation
synonym: "chromosome movement towards spindle pole during female meiosis" EXACT []
synonym: "female meiotic chromosome movement to spindle pole" EXACT []
synonym: "female meiotic chromosome movement" BROAD []
xref: GO:0016345

[Term]
id: CCO:P0000136
name: male meiotic chromosome movement towards spindle pole
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai]
is_a: CCO:P0000134 ! meiotic chromosome movement towards spindle pole
relationship: part_of CCO:P0000065 ! male meiosis chromosome segregation
synonym: "chromosome movement towards spindle pole during male meiosis" EXACT []
synonym: "male meiotic chromosome movement to spindle pole" EXACT []
synonym: "male meiotic chromosome movement" BROAD []
xref: GO:0016346

[Term]
id: CCO:P0000137
name: modification by virus of host cell cycle regulation
def: "Viral processes that modulate the rate of the host cell cycle to facilitate virus replication." [ISBN:0781718325]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
synonym: "viral perturbation of cell cycle regulation" EXACT []
xref: GO:0019055

[Term]
id: CCO:P0000138
name: actin filament reorganization during cell cycle
def: "The cell cycle process whereby rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah]
is_a: CCO:P0000308 ! cell cycle process
synonym: "actin filament reorganisation during cell cycle" EXACT []
xref: GO:0030037

[Term]
id: CCO:P0000139
name: regulation of mitotic metaphase/anaphase transition
def: "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000087 ! regulation of mitosis
relationship: part_of CCO:P0000090 ! mitotic metaphase/anaphase transition
xref: GO:0030071

[Term]
id: CCO:P0000140
name: mitotic spindle organization and biogenesis in nucleus
def: "The formation and maintenance of the spindle in the nucleus, as seen in Fungi during a mitotic cell cycle." [GOC:mah]
is_a: CCO:P0000058 ! mitotic spindle organization and biogenesis
synonym: "mitotic spindle organisation and biogenesis in nucleus" EXACT []
synonym: "spindle organization and biogenesis in nucleus during mitosis" EXACT []
synonym: "mitotic spindle assembly (sensu Fungi)" NARROW []
synonym: "mitotic spindle assembly (sensu Saccharomyces)" NARROW []
xref: GO:0030472
xref: GO:0000071

[Term]
id: CCO:P0000141
name: horsetail nuclear movement
def: "The cell cycle process whereby oscillatory movement of the nucleus during meiotic prophase I occurs. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, which may facilitate synapsis necessary for efficient meiotic recombination; as observed in S. pombe." [PMID:16111942, PMID:9572142]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000103 ! meiosis
synonym: "HNM" EXACT []
synonym: "horsetail movement" EXACT []
xref: GO:0030989

[Term]
id: CCO:P0000142
name: cell cycle arrest in response to nitrogen starvation
def: "The processes that lead to a halt in cell cycle progression (cessation of cell cycle transitions) as a result of deprivation of nitrogen." [GOC:vw]
is_a: CCO:P0000057 ! cell cycle arrest
xref: GO:0030996

[Term]
id: CCO:P0000143
name: regulation of centriole-centriole cohesion
def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968]
relationship: part_of CCO:P0000096 ! centrosome cycle
xref: GO:0030997

[Term]
id: CCO:P0000144
name: linear element formation
def: "The cell cycle process whereby a proteinaceous scaffold, related to the synaptonemal complex, is formed in association with S. pombe chromosomes during meiotic prophase." [GOC:mah, Sanger:jb]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000106 ! synapsis
xref: GO:0030999

[Term]
id: CCO:P0000145
name: septation initiation signaling
def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the begining of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007]
is_a: CCO:P0000173 ! regulation of contractile ring contraction during cytokinesis
synonym: "septation initiation network" EXACT []
synonym: "septation initiation signalling" EXACT []
synonym: "SIN" EXACT []
xref: GO:0031028

[Term]
id: CCO:P0000146
name: regulation of septation initiation signaling
def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah]
relationship: part_of CCO:P0000145 ! septation initiation signaling
synonym: "regulation of septation initiation network" EXACT []
synonym: "regulation of septation initiation signalling" EXACT []
xref: GO:0031029

[Term]
id: CCO:P0000147
name: negative regulation of septation initiation signaling
def: "Any process that stops, prevents or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah]
is_a: CCO:P0000146 ! regulation of septation initiation signaling
synonym: "down regulation of septation initiation signaling" EXACT []
synonym: "down-regulation of septation initiation signaling" EXACT []
synonym: "downregulation of septation initiation signaling" EXACT []
synonym: "negative regulation of septation initiation network" EXACT []
synonym: "negative regulation of septation initiation signalling" EXACT []
synonym: "inhibition of septation initiation signaling" NARROW []
xref: GO:0031030

[Term]
id: CCO:P0000148
name: positive regulation of septation initiation signaling
def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah]
is_a: CCO:P0000146 ! regulation of septation initiation signaling
synonym: "positive regulation of septation initiation network" EXACT []
synonym: "positive regulation of septation initiation signalling" EXACT []
synonym: "up regulation of septation initiation signaling" EXACT []
synonym: "up-regulation of septation initiation signaling" EXACT []
synonym: "upregulation of septation initiation signaling" EXACT []
synonym: "activation of septation initiation signaling" NARROW []
synonym: "stimulation of septation initiation signaling" NARROW []
xref: GO:0031031

[Term]
id: CCO:P0000149
name: sister chromatid biorientation
def: "The cell cycle process whereby sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000082 ! mitotic metaphase plate congression
synonym: "chromosome biorientation" EXACT []
synonym: "sister kinetochore biorientation" EXACT []
xref: GO:0031134

[Term]
id: CCO:P0000150
name: collapsed replication fork processing
def: "The process by which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired by a recombinational mechanism." [PMID:11459955, PMID:15367656]
relationship: part_of CCO:P0000160 ! intra-S DNA damage checkpoint
xref: GO:0031297

[Term]
id: CCO:P0000151
name: positive regulation of exit from mitosis
def: "Any processactivates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah]
is_a: CCO:P0000095 ! regulation of exit from mitosis
synonym: "up regulation of exit from mitosis" EXACT []
synonym: "up-regulation of exit from mitosis" EXACT []
synonym: "upregulation of exit from mitosis" EXACT []
synonym: "activation of exit from mitosis" NARROW []
synonym: "stimulation of exit from mitosis" NARROW []
xref: GO:0031536

[Term]
id: CCO:P0000152
name: cytokinesis checkpoint
def: "A cell cycle checkpoint that ensures the correct temporal ordering of nuclear division and cytokinesis; arrests the cell cycle in G2 upon perturbation of cytokinetic structures. In Schizosaccharomyces, the checkpoint monitors formation and integrity of medial actomyosin ring and septum." [GOC:mah, PMID:15647375]
is_a: CCO:P0000005 ! cell cycle checkpoint
synonym: "contractile ring checkpoint" EXACT []
xref: GO:0031565

[Term]
id: CCO:P0000153
name: cytokinesis, contractile ring maintenance
def: "The cell cycle process whereby the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures." [GOC:vw]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000152 ! cytokinesis checkpoint
xref: GO:0031566

[Term]
id: CCO:P0000154
name: cell size control checkpoint
def: "Any cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size." [GOC:mah]
is_a: CCO:P0000005 ! cell cycle checkpoint
xref: GO:0031567

[Term]
id: CCO:P0000155
name: G1/S transition size control checkpoint
def: "A cell cycle checkpoint that blocks cell cycle progression from G1 to S phase until cells have reached a critical size." [GOC:mah]
is_a: CCO:P0000154 ! cell size control checkpoint
is_a: CCO:P0000162 ! G1/S transition checkpoint
xref: GO:0031568

[Term]
id: CCO:P0000156
name: G2/M transition size control checkpoint
def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until cells have reached a critical size." [GOC:mah]
is_a: CCO:P0000154 ! cell size control checkpoint
is_a: CCO:P0000163 ! G2/M transition checkpoint
xref: GO:0031569

[Term]
id: CCO:P0000157
name: DNA integrity checkpoint
def: "Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure." [GOC:mah, GOC:vw]
is_a: CCO:P0000005 ! cell cycle checkpoint
xref: GO:0031570

[Term]
id: CCO:P0000158
name: G1 DNA damage checkpoint
def: "A cell cycle checkpoint that arrests cell cycle progression G1 phase in response to DNA damage." [GOC:mah]
is_a: CCO:P0000007 ! DNA damage checkpoint
xref: GO:0031571

[Term]
id: CCO:P0000159
name: G2/M transition DNA damage checkpoint
def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage." [GOC:mah]
is_a: CCO:P0000007 ! DNA damage checkpoint
is_a: CCO:P0000163 ! G2/M transition checkpoint
xref: GO:0031572

[Term]
id: CCO:P0000160
name: intra-S DNA damage checkpoint
def: "The slowing of DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession." [GOC:vw]
is_a: CCO:P0000007 ! DNA damage checkpoint
xref: GO:0031573

[Term]
id: CCO:P0000161
name: S-M checkpoint
def: "A cell cycle checkpoint which halts replication in response to nucleotide depletion." [GOC:vw]
is_a: CCO:P0000160 ! intra-S DNA damage checkpoint
xref: GO:0031574

[Term]
id: CCO:P0000162
name: G1/S transition checkpoint
def: "Any cell cycle checkpoint that blocks entry into S phase." [GOC:mah]
is_a: CCO:P0000005 ! cell cycle checkpoint
xref: GO:0031575

[Term]
id: CCO:P0000163
name: G2/M transition checkpoint
def: "Any cell cycle checkpoint that blocks entry into M phase." [GOC:mah]
is_a: CCO:P0000005 ! cell cycle checkpoint
synonym: "G2/M checkpoint" EXACT []
xref: GO:0031576

[Term]
id: CCO:P0000164
name: spindle checkpoint
def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until all chromosomes are attached to the spindle." [PMID:15897186]
is_a: CCO:P0000005 ! cell cycle checkpoint
synonym: "spindle assembly checkpoint" EXACT []
synonym: "SAC" BROAD []
xref: GO:0031577

[Term]
id: CCO:P0000165
name: spindle orientation checkpoint
def: "A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected." [GOC:clt, PMID:14616062]
is_a: CCO:P0000005 ! cell cycle checkpoint
synonym: "SOC" EXACT []
synonym: "spindle position checkpoint" EXACT []
synonym: "SPOC" EXACT []
xref: GO:0031578

[Term]
id: CCO:P0000166
name: homologous chromosome orientation during meiosis
def: "The cell cycle process whereby the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000183 ! meiotic metaphase I plate congression
synonym: "homologous chromosome orientation during meiosis I" EXACT []
xref: GO:0031619

[Term]
id: CCO:P0000167
name: G1/S-specific regulation of cyclin-dependent protein kinase activity
def: "Any process that modulates the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah]
is_a: CCO:P0000009 ! regulation of cyclin-dependent protein kinase activity
relationship: part_of CCO:P0000011 ! G1/S transition of mitotic cell cycle
xref: GO:0031657

[Term]
id: CCO:P0000168
name: G1/S-specific negative regulation of cyclin-dependent protein kinase activity
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah]
is_a: CCO:P0000167 ! G1/S-specific regulation of cyclin-dependent protein kinase activity
is_a: CCO:P0000194 ! negative regulation of cyclin-dependent protein kinase activity
synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
xref: GO:0031658

[Term]
id: CCO:P0000169
name: G1/S-specific positive regulation of cyclin-dependent protein kinase activity
def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah]
is_a: CCO:P0000167 ! G1/S-specific regulation of cyclin-dependent protein kinase activity
is_a: CCO:P0000195 ! positive regulation of cyclin-dependent protein kinase activity
synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW []
xref: GO:0031659

[Term]
id: CCO:P0000170
name: G2/M-specific regulation of cyclin-dependent protein kinase activity
def: "Any process that modulates the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah]
is_a: CCO:P0000009 ! regulation of cyclin-dependent protein kinase activity
relationship: part_of CCO:P0000015 ! G2/M transition of mitotic cell cycle
xref: GO:0031660

[Term]
id: CCO:P0000171
name: G2/M-specific negative regulation of cyclin-dependent protein kinase activity
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah]
is_a: CCO:P0000170 ! G2/M-specific regulation of cyclin-dependent protein kinase activity
is_a: CCO:P0000194 ! negative regulation of cyclin-dependent protein kinase activity
synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
xref: GO:0031661

[Term]
id: CCO:P0000172
name: G2/M-specific positive regulation of cyclin-dependent protein kinase activity
def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah]
is_a: CCO:P0000170 ! G2/M-specific regulation of cyclin-dependent protein kinase activity
is_a: CCO:P0000195 ! positive regulation of cyclin-dependent protein kinase activity
synonym: "G2/M-specific up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific upregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G2/M-specific stimulation of cyclin-dependent protein kinase activity" NARROW []
xref: GO:0031662

[Term]
id: CCO:P0000173
name: regulation of contractile ring contraction during cytokinesis
def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring during cytokinesis." [GOC:mah]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
xref: GO:0031991

[Term]
id: CCO:P0000174
name: attachment of telomeres to spindle pole body
def: "The cell cycle process whereby physical connections are formed between telomeres and the spindle pole body, facilitating bouquet formation." [PMID:16615890]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000190 ! telomere clustering
xref: GO:0032121

[Term]
id: CCO:P0000175
name: preblastoderm mitotic cell cycle
def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
is_a: CCO:P0000193 ! mitotic cell cycle, embryonic
xref: GO:0035185

[Term]
id: CCO:P0000176
name: syncytial blastoderm mitotic cell cycle
def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
is_a: CCO:P0000193 ! mitotic cell cycle, embryonic
xref: GO:0035186

[Term]
id: CCO:P0000177
name: establishment of mitotic spindle localization
def: "The cell cycle process whereby the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000037 ! mitotic cell cycle
synonym: "mitotic spindle positioning" EXACT []
synonym: "mitotic spindle positioning or orientation" EXACT []
synonym: "spindle positioning during mitosis" EXACT []
synonym: "mitotic spindle positioning (sensu Fungi)" NARROW []
synonym: "mitotic spindle positioning (sensu Saccharomyces)" NARROW []
synonym: "mitotic spindle positioning and orientation (sensu Saccharomyces)" NARROW []
synonym: "mitotic spindle positioning or orientation (sensu Fungi)" NARROW []
xref: GO:0040001
xref: GO:0018986
xref: GO:0030605
xref: GO:0030606
xref: GO:0030608
xref: GO:0030610

[Term]
id: CCO:P0000178
name: regulation of meiosis
def: "Any process that modulates the frequency, rate or extent of meiosis, the process by which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
relationship: part_of CCO:P0000103 ! meiosis
xref: GO:0040020

[Term]
id: CCO:P0000179
name: polar body extrusion after meiotic divisions
def: "The cell cycle process whereby two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000120 ! female meiosis
xref: GO:0040038

[Term]
id: CCO:P0000180
name: meiotic DNA double-strand break formation
def: "The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000054 ! meiotic gene conversion
relationship: part_of CCO:P0000108 ! meiotic recombination
xref: GO:0042138

[Term]
id: CCO:P0000181
name: early meiotic recombination nodule assembly
def: "The assembly of small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324]
is_a: CCO:P0000122 ! meiotic recombination nodule assembly
xref: GO:0042139

[Term]
id: CCO:P0000182
name: late meiotic recombination nodule assembly
def: "The assembly of small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324]
is_a: CCO:P0000122 ! meiotic recombination nodule assembly
xref: GO:0042140

[Term]
id: CCO:P0000183
name: meiotic metaphase I plate congression
def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666]
is_a: CCO:P0000257 ! meiotic metaphase plate congression
relationship: part_of CCO:P0000191 ! homologous chromosome segregation
xref: GO:0043060

[Term]
id: CCO:P0000184
name: meiotic metaphase II plate congression
def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666]
is_a: CCO:P0000257 ! meiotic metaphase plate congression
relationship: part_of CCO:P0000192 ! meiotic sister chromatid segregation
xref: GO:0043061

[Term]
id: CCO:P0000185
name: meiotic spindle stabilization
def: "The cell cycle process whereby spindle integrity is maintained during M phase of meiosis." [GOC:go_curators]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000029 ! meiotic spindle organization and biogenesis
xref: GO:0043147

[Term]
id: CCO:P0000186
name: mitotic spindle stabilization
def: "The cell cycle process whereby spindle integrity is maintained during M phase of mitosis." [GOC:go_curators]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000058 ! mitotic spindle organization and biogenesis
xref: GO:0043148

[Term]
id: CCO:P0000187
name: G0 to G1 transition
def: "The transition from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [ISBN:0716731363]
is_a: CCO:P0000040 ! re-entry into mitotic cell cycle
xref: GO:0045023

[Term]
id: CCO:P0000188
name: negative regulation of meiotic recombination
def: "Any process that stops, prevents or reduces the frequency, rate or extent of recombination during meiosis." [GOC:ai]
is_a: CCO:P0000200 ! negative regulation of meiosis
relationship: part_of CCO:P0000108 ! meiotic recombination
synonym: "down regulation of meiotic recombination" EXACT []
synonym: "down-regulation of meiotic recombination" EXACT []
synonym: "downregulation of meiotic recombination" EXACT []
synonym: "suppression of meiotic recombination" EXACT []
synonym: "inhibition of meiotic recombination" NARROW []
xref: GO:0045128

[Term]
id: CCO:P0000189
name: meiotic chromosome segregation
def: "The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle." [GOC:ai]
relationship: part_of CCO:P0000103 ! meiosis
xref: GO:0045132

[Term]
id: CCO:P0000190
name: telomere clustering
def: "The cell cycle process whereby the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in homologous chromosome pairing and therefore progression through meiosis." [GOC:vw, PMID:10690419]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000103 ! meiosis
synonym: "bouquet biosynthesis" NARROW []
synonym: "bouquet formation" NARROW []
xref: GO:0045141

[Term]
id: CCO:P0000191
name: homologous chromosome segregation
def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000104 ! meiosis I
relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
synonym: "meiosis I, chromosome segregation" EXACT []
xref: GO:0045143
xref: GO:0007061

[Term]
id: CCO:P0000192
name: meiotic sister chromatid segregation
def: "The cell cycle process whereby sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000112 ! meiosis II
relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
synonym: "meiosis II, chromosome segregation" EXACT []
xref: GO:0045144

[Term]
id: CCO:P0000193
name: mitotic cell cycle, embryonic
def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
is_a: CCO:P0000037 ! mitotic cell cycle
xref: GO:0045448

[Term]
id: CCO:P0000194
name: negative regulation of cyclin-dependent protein kinase activity
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity." [GOC:go_curators]
is_a: CCO:P0000009 ! regulation of cyclin-dependent protein kinase activity
is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
synonym: "CDK inhibitor" RELATED []
synonym: "cyclin-dependent kinase inhibitor" RELATED []
synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "negative regulation of CDK activity" EXACT []
synonym: "inhibition of cyclin-dependent protein kinase activity" NARROW []
xref: GO:0045736

[Term]
id: CCO:P0000195
name: positive regulation of cyclin-dependent protein kinase activity
def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators]
is_a: CCO:P0000009 ! regulation of cyclin-dependent protein kinase activity
is_a: CCO:P0000199 ! positive regulation of progression through cell cycle
synonym: "positive regulation of CDK activity" EXACT []
synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "stimulation of cyclin-dependent protein kinase activity" NARROW []
xref: GO:0045737

[Term]
id: CCO:P0000196
name: negative regulation of S phase of mitotic cell cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
is_a: CCO:P0000089 ! regulation of S phase of mitotic cell cycle
is_a: CCO:P0000208 ! negative regulation of progression through mitotic cell cycle
synonym: "down regulation of S phase of mitotic cell cycle" EXACT []
synonym: "down-regulation of S phase of mitotic cell cycle" EXACT []
synonym: "downregulation of S phase of mitotic cell cycle" EXACT []
synonym: "inhibition of S phase of mitotic cell cycle" NARROW []
xref: GO:0045749

[Term]
id: CCO:P0000197
name: positive regulation of S phase of mitotic cell cycle
def: "Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
is_a: CCO:P0000089 ! regulation of S phase of mitotic cell cycle
is_a: CCO:P0000209 ! positive regulation of progression through mitotic cell cycle
synonym: "up regulation of S phase of mitotic cell cycle" EXACT []
synonym: "up-regulation of S phase of mitotic cell cycle" EXACT []
synonym: "upregulation of S phase of mitotic cell cycle" EXACT []
synonym: "activation of S phase of mitotic cell cycle" NARROW []
synonym: "stimulation of S phase of mitotic cell cycle" NARROW []
xref: GO:0045750

[Term]
id: CCO:P0000198
name: negative regulation of progression through cell cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the cell cycle." [GOC:go_curators]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
synonym: "down regulation of progression through cell cycle" EXACT []
synonym: "down-regulation of progression through cell cycle" EXACT []
synonym: "downregulation of progression through cell cycle" EXACT []
synonym: "negative regulation of cell cycle progression" EXACT []
synonym: "inhibition of progression through cell cycle" NARROW []
xref: GO:0045786

[Term]
id: CCO:P0000199
name: positive regulation of progression through cell cycle
def: "Any process that activates or increases the frequency, rate or extent of progression through the cell cycle." [GOC:go_curators]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
synonym: "positive regulation of cell cycle progression" EXACT []
synonym: "up regulation of progression through cell cycle" EXACT []
synonym: "up-regulation of progression through cell cycle" EXACT []
synonym: "upregulation of progression through cell cycle" EXACT []
synonym: "activation of progression through cell cycle" NARROW []
synonym: "stimulation of progression through cell cycle" NARROW []
xref: GO:0045787

[Term]
id: CCO:P0000200
name: negative regulation of meiosis
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiosis." [GOC:go_curators]
is_a: CCO:P0000178 ! regulation of meiosis
synonym: "down regulation of meiosis" EXACT []
synonym: "down-regulation of meiosis" EXACT []
synonym: "downregulation of meiosis" EXACT []
synonym: "inhibition of meiosis" NARROW []
xref: GO:0045835

[Term]
id: CCO:P0000201
name: positive regulation of meiosis
def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators]
is_a: CCO:P0000178 ! regulation of meiosis
synonym: "up regulation of meiosis" EXACT []
synonym: "up-regulation of meiosis" EXACT []
synonym: "upregulation of meiosis" EXACT []
synonym: "activation of meiosis" NARROW []
synonym: "stimulation of meiosis" NARROW []
xref: GO:0045836

[Term]
id: CCO:P0000202
name: negative regulation of mitosis
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitosis." [GOC:go_curators]
is_a: CCO:P0000087 ! regulation of mitosis
is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
synonym: "down regulation of mitosis" EXACT []
synonym: "down-regulation of mitosis" EXACT []
synonym: "downregulation of mitosis" EXACT []
synonym: "inhibition of mitosis" NARROW []
xref: GO:0045839

[Term]
id: CCO:P0000203
name: positive regulation of mitosis
def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators]
is_a: CCO:P0000087 ! regulation of mitosis
is_a: CCO:P0000199 ! positive regulation of progression through cell cycle
synonym: "up regulation of mitosis" EXACT []
synonym: "up-regulation of mitosis" EXACT []
synonym: "upregulation of mitosis" EXACT []
synonym: "activation of mitosis" NARROW []
synonym: "mitogenic activity" NARROW []
synonym: "stimulation of mitosis" NARROW []
xref: GO:0045840

[Term]
id: CCO:P0000204
name: negative regulation of mitotic metaphase/anaphase transition
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
is_a: CCO:P0000139 ! regulation of mitotic metaphase/anaphase transition
is_a: CCO:P0000202 ! negative regulation of mitosis
synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW []
xref: GO:0045841

[Term]
id: CCO:P0000205
name: positive regulation of mitotic metaphase/anaphase transition
def: "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
is_a: CCO:P0000139 ! regulation of mitotic metaphase/anaphase transition
is_a: CCO:P0000203 ! positive regulation of mitosis
synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "activation of mitotic metaphase/anaphase transition" NARROW []
synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW []
xref: GO:0045842

[Term]
id: CCO:P0000206
name: regulation of transcription, mitotic
def: "A cell cycle process that modulates the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000069 ! mitosis
synonym: "mitotic regulation of transcription" EXACT []
xref: GO:0045896

[Term]
id: CCO:P0000207
name: positive regulation of transcription, mitotic
def: "Any process that activates or increases the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
is_a: CCO:P0000206 ! regulation of transcription, mitotic
synonym: "mitotic activation of transcription" EXACT []
synonym: "up regulation of transcription, mitotic" EXACT []
synonym: "up-regulation of transcription, mitotic" EXACT []
synonym: "upregulation of transcription, mitotic" EXACT []
synonym: "activation of transcription, mitotic" NARROW []
synonym: "stimulation of transcription, mitotic" NARROW []
xref: GO:0045897

[Term]
id: CCO:P0000208
name: negative regulation of progression through mitotic cell cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000124 ! regulation of progression through mitotic cell cycle
is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
synonym: "down regulation of progression through mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through mitotic cell cycle" EXACT []
synonym: "downregulation of progression through mitotic cell cycle" EXACT []
synonym: "negative regulation of mitotic cell cycle" EXACT []
synonym: "negative regulation of mitotic cell cycle progression" EXACT []
synonym: "inhibition of progression through mitotic cell cycle" NARROW []
xref: GO:0045930

[Term]
id: CCO:P0000209
name: positive regulation of progression through mitotic cell cycle
def: "Any process that activates or increases the frequency, rate or extent of progression through the mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000124 ! regulation of progression through mitotic cell cycle
is_a: CCO:P0000199 ! positive regulation of progression through cell cycle
synonym: "positive regulation of mitotic cell cycle" EXACT []
synonym: "positive regulation of mitotic cell cycle progression" EXACT []
synonym: "up regulation of progression through mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through mitotic cell cycle" EXACT []
synonym: "upregulation of progression through mitotic cell cycle" EXACT []
synonym: "activation of progression through mitotic cell cycle" NARROW []
synonym: "stimulation of progression through mitotic cell cycle" NARROW []
xref: GO:0045931

[Term]
id: CCO:P0000210
name: negative regulation of progression through embryonic mitotic cell cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000129 ! regulation of progression through embryonic mitotic cell cycle
is_a: CCO:P0000208 ! negative regulation of progression through mitotic cell cycle
synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW []
xref: GO:0045976

[Term]
id: CCO:P0000211
name: positive regulation of mitotic cell cycle, embryonic
def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000129 ! regulation of progression through embryonic mitotic cell cycle
is_a: CCO:P0000209 ! positive regulation of progression through mitotic cell cycle
synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "up regulation of mitotic cell cycle, embryonic" EXACT []
synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT []
synonym: "upregulation of mitotic cell cycle, embryonic" EXACT []
synonym: "activation of mitotic cell cycle, embryonic" NARROW []
synonym: "stimulation of mitotic cell cycle, embryonic" NARROW []
xref: GO:0045977

[Term]
id: CCO:P0000212
name: negative regulation of progression through preblastoderm mitotic cell cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000125 ! regulation of progression through preblastoderm mitotic cell cycle
is_a: CCO:P0000210 ! negative regulation of progression through embryonic mitotic cell cycle
synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW []
xref: GO:0046001

[Term]
id: CCO:P0000213
name: positive regulation of progression through preblastoderm mitotic cell cycle
def: "Any process that activates or increases the frequency, rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000125 ! regulation of progression through preblastoderm mitotic cell cycle
is_a: CCO:P0000211 ! positive regulation of mitotic cell cycle, embryonic
synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW []
xref: GO:0046002

[Term]
id: CCO:P0000214
name: negative regulation of progression through syncytial blastoderm mitotic cell cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000126 ! regulation of progression through syncytial blastoderm mitotic cell cycle
is_a: CCO:P0000210 ! negative regulation of progression through embryonic mitotic cell cycle
synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW []
xref: GO:0046003

[Term]
id: CCO:P0000215
name: positive regulation of progression through syncytial blastoderm mitotic cell cycle
def: "Any process that activates or increases the frequency, rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:go_curators]
is_a: CCO:P0000126 ! regulation of progression through syncytial blastoderm mitotic cell cycle
is_a: CCO:P0000211 ! positive regulation of mitotic cell cycle, embryonic
synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
xref: GO:0046004

[Term]
id: CCO:P0000216
name: regulation of transcription from RNA polymerase I promoter, mitotic
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000206 ! regulation of transcription, mitotic
synonym: "mitotic regulation of transcription from Pol I promoter" EXACT []
synonym: "regulation of transcription from Pol I promoter, mitotic" EXACT []
xref: GO:0046017

[Term]
id: CCO:P0000217
name: positive regulation of transcription from RNA polymerase I promoter, mitotic
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
is_a: CCO:P0000207 ! positive regulation of transcription, mitotic
is_a: CCO:P0000216 ! regulation of transcription from RNA polymerase I promoter, mitotic
synonym: "mitotic activation of transcription from Pol I promoter" EXACT []
synonym: "positive regulation of transcription from Pol I promoter, mitotic" EXACT []
synonym: "up regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "up-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "upregulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "activation of transcription from RNA polymerase I promoter, mitotic" NARROW []
synonym: "stimulation of transcription from RNA polymerase I promoter, mitotic" NARROW []
xref: GO:0046018

[Term]
id: CCO:P0000218
name: regulation of transcription from RNA polymerase II promoter, mitotic
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000206 ! regulation of transcription, mitotic
synonym: "mitotic regulation of transcription from Pol II promoter" EXACT []
synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT []
xref: GO:0046021

[Term]
id: CCO:P0000219
name: positive regulation of transcription from RNA polymerase II promoter, mitotic
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
is_a: CCO:P0000207 ! positive regulation of transcription, mitotic
is_a: CCO:P0000218 ! regulation of transcription from RNA polymerase II promoter, mitotic
synonym: "mitotic activation of transcription from Pol II promoter" EXACT []
synonym: "positive regulation of transcription from Pol II promoter, mitotic" EXACT []
synonym: "up regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "activation of transcription from RNA polymerase II promoter, mitotic" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter, mitotic" NARROW []
xref: GO:0046022

[Term]
id: CCO:P0000220
name: regulation of transcription from RNA polymerase III promoter, mitotic
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000206 ! regulation of transcription, mitotic
synonym: "mitotic regulation of transcription from Pol III promoter" EXACT []
synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT []
xref: GO:0046023

[Term]
id: CCO:P0000221
name: positive regulation of transcription from RNA polymerase III promoter, mitotic
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
is_a: CCO:P0000207 ! positive regulation of transcription, mitotic
is_a: CCO:P0000220 ! regulation of transcription from RNA polymerase III promoter, mitotic
synonym: "mitotic activation of transcription from Pol III promoter" EXACT []
synonym: "positive regulation of transcription from Pol III promoter, mitotic" EXACT []
synonym: "up regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "up-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "upregulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "activation of transcription from RNA polymerase III promoter, mitotic" NARROW []
synonym: "stimulation of transcription from RNA polymerase III promoter, mitotic" NARROW []
xref: GO:0046024

[Term]
id: CCO:P0000222
name: regulation of centriole replication
def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]
is_a: CCO:P0000228 ! regulation of centrosome cycle
relationship: part_of CCO:P0000097 ! centriole replication
xref: GO:0046599

[Term]
id: CCO:P0000223
name: negative regulation of centriole replication
def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole replication." [GOC:ai]
is_a: CCO:P0000222 ! regulation of centriole replication
is_a: CCO:P0000229 ! negative regulation of centrosome cycle
synonym: "down regulation of centriole replication" EXACT []
synonym: "down-regulation of centriole replication" EXACT []
synonym: "downregulation of centriole replication" EXACT []
synonym: "inhibition of centriole replication" NARROW []
xref: GO:0046600

[Term]
id: CCO:P0000224
name: positive regulation of centriole replication
def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai]
is_a: CCO:P0000222 ! regulation of centriole replication
is_a: CCO:P0000230 ! positive regulation of centrosome cycle
synonym: "up regulation of centriole replication" EXACT []
synonym: "up-regulation of centriole replication" EXACT []
synonym: "upregulation of centriole replication" EXACT []
synonym: "activation of centriole replication" NARROW []
synonym: "stimulation of centriole replication" NARROW []
xref: GO:0046601

[Term]
id: CCO:P0000225
name: regulation of mitotic centrosome separation
def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai]
is_a: CCO:P0000228 ! regulation of centrosome cycle
relationship: part_of CCO:P0000098 ! mitotic centrosome separation
xref: GO:0046602

[Term]
id: CCO:P0000226
name: negative regulation of mitotic centrosome separation
def: "Any process that stops, prevents or reduces the frequency, rate or extent of centrosome separation." [GOC:ai]
is_a: CCO:P0000225 ! regulation of mitotic centrosome separation
is_a: CCO:P0000229 ! negative regulation of centrosome cycle
synonym: "down regulation of mitotic centrosome separation" EXACT []
synonym: "down-regulation of mitotic centrosome separation" EXACT []
synonym: "downregulation of mitotic centrosome separation" EXACT []
synonym: "inhibition of mitotic centrosome separation" NARROW []
xref: GO:0046603

[Term]
id: CCO:P0000227
name: positive regulation of mitotic centrosome separation
def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai]
is_a: CCO:P0000225 ! regulation of mitotic centrosome separation
is_a: CCO:P0000230 ! positive regulation of centrosome cycle
synonym: "up regulation of mitotic centrosome separation" EXACT []
synonym: "up-regulation of mitotic centrosome separation" EXACT []
synonym: "upregulation of mitotic centrosome separation" EXACT []
synonym: "activation of mitotic centrosome separation" NARROW []
synonym: "stimulation of mitotic centrosome separation" NARROW []
xref: GO:0046604

[Term]
id: CCO:P0000228
name: regulation of centrosome cycle
def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai]
relationship: part_of CCO:P0000096 ! centrosome cycle
xref: GO:0046605

[Term]
id: CCO:P0000229
name: negative regulation of centrosome cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai]
is_a: CCO:P0000228 ! regulation of centrosome cycle
synonym: "down regulation of centrosome cycle" EXACT []
synonym: "down-regulation of centrosome cycle" EXACT []
synonym: "downregulation of centrosome cycle" EXACT []
synonym: "inhibition of centrosome cycle" NARROW []
xref: GO:0046606

[Term]
id: CCO:P0000230
name: positive regulation of centrosome cycle
def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai]
is_a: CCO:P0000228 ! regulation of centrosome cycle
synonym: "up regulation of centrosome cycle" EXACT []
synonym: "up-regulation of centrosome cycle" EXACT []
synonym: "upregulation of centrosome cycle" EXACT []
synonym: "activation of centrosome cycle" NARROW []
synonym: "stimulation of centrosome cycle" NARROW []
xref: GO:0046607

[Term]
id: CCO:P0000231
name: suppression by virus of host cell cycle arrest
def: "Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur." [PMID:9371605]
is_a: CCO:P0000137 ! modification by virus of host cell cycle regulation
synonym: "negative regulation by virus of cell cycle arrest" EXACT []
synonym: "viral inhibition of cell cycle arrest" EXACT []
xref: GO:0046792

[Term]
id: CCO:P0000232
name: replication fork protection
def: "Processes preventing the collapse of stalled replication forks." [GOC:vw, PMID:14560029]
relationship: part_of CCO:P0000160 ! intra-S DNA damage checkpoint
synonym: "replication fork maintenance" BROAD []
synonym: "replication fork stabilization" BROAD []
xref: GO:0048478

[Term]
id: CCO:P0000233
name: chiasma formation
def: "The cell cycle process whereby a connection between chromatids forms, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [http:www.onelook.com]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000106 ! synapsis
xref: GO:0051026

[Term]
id: CCO:P0000234
name: regulation of transcription, meiotic
def: "Any process that modulates the frequency, rate or extent of transcription during meiosis." [GOC:go_curators]
relationship: part_of CCO:P0000103 ! meiosis
synonym: "meiotic regulation of transcription" EXACT []
xref: GO:0051037

[Term]
id: CCO:P0000235
name: negative regulation of transcription, meiotic
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during meiosis." [GOC:ai]
is_a: CCO:P0000234 ! regulation of transcription, meiotic
synonym: "down regulation of transcription, meiotic" EXACT []
synonym: "down-regulation of transcription, meiotic" EXACT []
synonym: "downregulation of transcription, meiotic" EXACT []
synonym: "meiotic repression of transcription" EXACT []
synonym: "negative regulation of meiotic transcription" EXACT []
synonym: "inhibition of transcription, meiotic" NARROW []
xref: GO:0051038

[Term]
id: CCO:P0000236
name: positive regulation of transcription, meiotic
def: "Any process that activates or increases the frequency, rate or extent of transcription during meiosis." [GOC:ai]
is_a: CCO:P0000234 ! regulation of transcription, meiotic
synonym: "positive regulation of meiotic transcription" EXACT []
synonym: "up regulation of transcription, meiotic" EXACT []
synonym: "up-regulation of transcription, meiotic" EXACT []
synonym: "upregulation of transcription, meiotic" EXACT []
synonym: "activation of transcription, meiotic" NARROW []
synonym: "stimulation of transcription, meiotic" NARROW []
xref: GO:0051039

[Term]
id: CCO:P0000237
name: meiotic nuclear envelope disassembly
def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000265 ! meiotic cell cycle
synonym: "meiotic nuclear envelope breakdown" EXACT []
synonym: "meiotic nuclear envelope catabolism" EXACT []
synonym: "meiotic nuclear envelope degradation" EXACT []
xref: GO:0051078

[Term]
id: CCO:P0000238
name: meiosis I nuclear envelope disassembly
def: "The controlled breakdown of the nuclear envelope during the first division of meiosis." [GOC:bf]
is_a: CCO:P0000237 ! meiotic nuclear envelope disassembly
relationship: part_of CCO:P0000104 ! meiosis I
synonym: "meiosis I nuclear envelope breakdown" EXACT []
synonym: "meiosis I nuclear envelope catabolism" EXACT []
synonym: "meiosis I nuclear envelope degradation" EXACT []
xref: GO:0051079

[Term]
id: CCO:P0000239
name: meiosis II nuclear envelope disassembly
def: "The controlled breakdown of the nuclear envelope during the second division of meiosis." [GOC:bf]
is_a: CCO:P0000237 ! meiotic nuclear envelope disassembly
relationship: part_of CCO:P0000112 ! meiosis II
synonym: "meiosis II nuclear envelope breakdown" EXACT []
synonym: "meiosis II nuclear envelope catabolism" EXACT []
synonym: "meiosis II nuclear envelope degradation" EXACT []
xref: GO:0051080

[Term]
id: CCO:P0000240
name: meiotic sister chromatid cohesion
def: "The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000104 ! meiosis I
relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
xref: GO:0051177

[Term]
id: CCO:P0000241
name: meiotic chromosome decondensation
def: "The cell cycle process whereby chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
xref: GO:0051178

[Term]
id: CCO:P0000242
name: meiotic spindle assembly
def: "The formation of the spindle during a meiotic cell cycle." [GOC:ai]
is_a: CCO:P0000029 ! meiotic spindle organization and biogenesis
synonym: "meiotic spindle biogenesis" EXACT []
synonym: "meiotic spindle biosynthesis" EXACT []
synonym: "meiotic spindle formation" EXACT []
synonym: "spindle assembly during meiosis" EXACT []
synonym: "spindle biogenesis during meiosis" EXACT []
synonym: "spindle formation during meiosis" EXACT []
synonym: "bipolar spindle biosynthesis" BROAD []
synonym: "bipolar spindle formation" BROAD []
xref: GO:0051226

[Term]
id: CCO:P0000243
name: mitotic spindle assembly
def: "The formation of the spindle during a mitotic cell cycle." [GOC:ai]
is_a: CCO:P0000058 ! mitotic spindle organization and biogenesis
synonym: "mitotic spindle biogenesis" EXACT []
synonym: "mitotic spindle biosynthesis" EXACT []
synonym: "mitotic spindle formation" EXACT []
synonym: "spindle assembly during mitosis" EXACT []
synonym: "spindle biogenesis during mitosis" EXACT []
synonym: "spindle formation during mitosis" EXACT []
xref: GO:0051227

[Term]
id: CCO:P0000244
name: mitotic spindle disassembly
def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai]
is_a: CCO:P0000058 ! mitotic spindle organization and biogenesis
synonym: "mitotic spindle breakdown" EXACT []
synonym: "mitotic spindle catabolism" EXACT []
synonym: "mitotic spindle degradation" EXACT []
synonym: "spindle breakdown during mitosis" EXACT []
synonym: "spindle degradation during mitosis" EXACT []
synonym: "spindle disassembly during mitosis" EXACT []
xref: GO:0051228

[Term]
id: CCO:P0000245
name: meiotic spindle disassembly
def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai]
is_a: CCO:P0000029 ! meiotic spindle organization and biogenesis
synonym: "meiotic spindle breakdown" EXACT []
synonym: "meiotic spindle catabolism" EXACT []
synonym: "meiotic spindle degradation" EXACT []
synonym: "spindle breakdown during meiosis" EXACT []
synonym: "spindle degradation during meiosis" EXACT []
synonym: "spindle disassembly during meiosis" EXACT []
xref: GO:0051229

[Term]
id: CCO:P0000246
name: meiotic spindle elongation
def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai]
is_a: CCO:P0000310 ! spindle elongation
relationship: part_of CCO:P0000029 ! meiotic spindle organization and biogenesis
synonym: "spindle elongation during meiosis" EXACT []
xref: GO:0051232

[Term]
id: CCO:P0000247
name: mitotic spindle midzone assembly
def: "The formation of the mitotic spindle midzone, the area in the center of the mitotic spindle where the spindle microtubules from opposite poles overlap." [GOC:ai]
is_a: CCO:P0000311 ! spindle midzone assembly
relationship: part_of CCO:P0000243 ! mitotic spindle assembly
synonym: "mitotic spindle midzone biogenesis" EXACT []
synonym: "mitotic spindle midzone biosynthesis" EXACT []
synonym: "mitotic spindle midzone formation" EXACT []
synonym: "spindle midzone assembly during mitosis" EXACT []
synonym: "spindle midzone biogenesis during mitosis" EXACT []
synonym: "spindle midzone formation during mitosis" EXACT []
xref: GO:0051256

[Term]
id: CCO:P0000248
name: meiotic spindle midzone assembly
def: "The formation of the meiotic spindle midzone, the area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:ai]
is_a: CCO:P0000311 ! spindle midzone assembly
relationship: part_of CCO:P0000242 ! meiotic spindle assembly
synonym: "meiotic spindle midzone biogenesis" EXACT []
synonym: "meiotic spindle midzone biosynthesis" EXACT []
synonym: "meiotic spindle midzone formation" EXACT []
synonym: "spindle midzone assembly during meiosis" EXACT []
synonym: "spindle midzone biogenesis during meiosis" EXACT []
synonym: "spindle midzone formation during meiosis" EXACT []
xref: GO:0051257

[Term]
id: CCO:P0000249
name: establishment of meiotic spindle localization
def: "The cell cycle process whereby the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000265 ! meiotic cell cycle
synonym: "meiotic spindle positioning" EXACT []
synonym: "spindle positioning during meiosis" EXACT []
xref: GO:0051295

[Term]
id: CCO:P0000250
name: establishment of meiotic spindle orientation
def: "The processes that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai]
is_a: CCO:P0000249 ! establishment of meiotic spindle localization
synonym: "establishment of spindle orientation during meiosis" EXACT []
synonym: "meiotic spindle orientation" EXACT []
synonym: "orienting of meiotic spindle" EXACT []
xref: GO:0051296

[Term]
id: CCO:P0000251
name: centrosome duplication
def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
relationship: part_of CCO:P0000096 ! centrosome cycle
synonym: "centrosome replication" EXACT []
xref: GO:0051298

[Term]
id: CCO:P0000252
name: centrosome separation
def: "The process by which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
relationship: part_of CCO:P0000096 ! centrosome cycle
xref: GO:0051299

[Term]
id: CCO:P0000253
name: mitotic sister chromatid separation
def: "The process by which sister chromatids are physically detached from each other during mitosis." [GOC:ai]
is_a: CCO:P0000312 ! chromosome separation
relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
synonym: "chromosome separation during mitosis" RELATED []
synonym: "mitotic chromosome separation" RELATED []
synonym: "sister chromatid separation during mitosis" EXACT []
xref: GO:0051306

[Term]
id: CCO:P0000254
name: meiotic chromosome separation
def: "The process by which chromosomes are physically detached from each other during meiosis." [GOC:ai]
is_a: CCO:P0000312 ! chromosome separation
relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
synonym: "chromosome separation during meiosis" EXACT []
xref: GO:0051307

[Term]
id: CCO:P0000255
name: male meiosis chromosome separation
def: "The process by which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai]
is_a: CCO:P0000065 ! male meiosis chromosome segregation
is_a: CCO:P0000254 ! meiotic chromosome separation
synonym: "chromosome separation during male meiosis" EXACT []
xref: GO:0051308

[Term]
id: CCO:P0000256
name: female meiosis chromosome separation
def: "The process by which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai]
is_a: CCO:P0000132 ! female meiosis chromosome segregation
is_a: CCO:P0000254 ! meiotic chromosome separation
synonym: "chromosome separation during female meiosis" EXACT []
xref: GO:0051309

[Term]
id: CCO:P0000257
name: meiotic metaphase plate congression
def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
synonym: "metaphase plate congression during meiosis" EXACT []
xref: GO:0051311

[Term]
id: CCO:P0000258
name: attachment of spindle microtubules to mitotic chromosome
def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during mitosis." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
xref: GO:0051314

[Term]
id: CCO:P0000259
name: attachment of spindle microtubules to kinetochore during mitosis
def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
xref: GO:0051315

[Term]
id: CCO:P0000260
name: attachment of spindle microtubules to kinetochore during meiotic chromosome segregation
def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiotic chromosome segregation." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED []
xref: GO:0051316

[Term]
id: CCO:P0000261
name: attachment of spindle microtubules to meiotic chromosome
def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during meiosis." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
xref: GO:0051317

[Term]
id: CCO:P0000262
name: G1 phase
def: "Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:ai]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000269 ! interphase
xref: GO:0051318

[Term]
id: CCO:P0000263
name: G2 phase
def: "Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:ai]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000269 ! interphase
xref: GO:0051319

[Term]
id: CCO:P0000264
name: S phase
def: "Progression through S phase, the part of the cell cycle during which DNA synthesis takes place." [GOC:ai]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000269 ! interphase
xref: GO:0051320

[Term]
id: CCO:P0000265
name: meiotic cell cycle
def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai]
is_a: CCO:P0000056 ! cell cycle
xref: GO:0051321

[Term]
id: CCO:P0000266
name: anaphase
def: "Progression through anaphase, the third stage of chromosome segregation in the cell cycle. Canonically, sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle." [http:www.onelook.com]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000038 ! M phase
xref: GO:0051322

[Term]
id: CCO:P0000267
name: metaphase
def: "Progression through metaphase, the second stage of chromosome segregation in the cell cycle. Canonically, chromosomes become aligned on the equatorial plate of the cell." [http:www.onelook.com]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000038 ! M phase
xref: GO:0051323

[Term]
id: CCO:P0000268
name: prophase
def: "Progression through prophase, the first stage of chromosome segregation in the cell cycle. Canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:ai]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000038 ! M phase
xref: GO:0051324

[Term]
id: CCO:P0000269
name: interphase
def: "Progression through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [http:www.onelook.com]
is_a: CCO:P0000309 ! cell cycle phase
synonym: "karyostasis" EXACT []
synonym: "resting phase" BROAD []
xref: GO:0051325

[Term]
id: CCO:P0000270
name: telophase
def: "Progression through telophase, the last stage of chromosome segregation in the cell cycle. Canonically, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [http:www.onelook.com]
is_a: CCO:P0000309 ! cell cycle phase
relationship: part_of CCO:P0000038 ! M phase
xref: GO:0051326

[Term]
id: CCO:P0000271
name: M phase of meiotic cell cycle
def: "Progression through M phase, the part of the meiotic cell cycle during which meiosis and cytokinesis take place." [GOC:ai]
is_a: CCO:P0000038 ! M phase
relationship: part_of CCO:P0000265 ! meiotic cell cycle
xref: GO:0051327

[Term]
id: CCO:P0000272
name: interphase of meiotic cell cycle
def: "Progression through interphase, the stage of cell cycle between successive rounds of meiosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai]
is_a: CCO:P0000269 ! interphase
relationship: part_of CCO:P0000265 ! meiotic cell cycle
xref: GO:0051328

[Term]
id: CCO:P0000273
name: interphase of mitotic cell cycle
def: "Progression through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai]
is_a: CCO:P0000269 ! interphase
relationship: part_of CCO:P0000037 ! mitotic cell cycle
xref: GO:0051329

[Term]
id: CCO:P0000274
name: G1 phase of meiotic cell cycle
def: "Progression through G1 phase, one of two 'gap' phases in the meiotic cell cycle; G1 is the interval between the completion of meiosis and the beginning of DNA synthesis." [GOC:ai]
is_a: CCO:P0000262 ! G1 phase
relationship: part_of CCO:P0000272 ! interphase of meiotic cell cycle
xref: GO:0051330

[Term]
id: CCO:P0000275
name: G2 phase of meiotic cell cycle
def: "Progression through G2 phase, one of two 'gap' phases in the meiotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of meiosis." [GOC:ai]
is_a: CCO:P0000263 ! G2 phase
relationship: part_of CCO:P0000272 ! interphase of meiotic cell cycle
xref: GO:0051331

[Term]
id: CCO:P0000276
name: S phase of meiotic cell cycle
def: "Progression through S phase, the part of the meiotic cell cycle during which DNA synthesis takes place." [GOC:ai]
is_a: CCO:P0000264 ! S phase
relationship: part_of CCO:P0000272 ! interphase of meiotic cell cycle
xref: GO:0051332

[Term]
id: CCO:P0000277
name: meiotic nuclear envelope reassembly
def: "The cell cycle process whereby the reformation of the nuclear envelope during meiosis occurs." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000265 ! meiotic cell cycle
xref: GO:0051333

[Term]
id: CCO:P0000278
name: meiosis I nuclear envelope reassembly
def: "The reformation of the nuclear envelope during meiosis I." [GOC:ai]
is_a: CCO:P0000277 ! meiotic nuclear envelope reassembly
relationship: part_of CCO:P0000104 ! meiosis I
xref: GO:0051334

[Term]
id: CCO:P0000279
name: meiosis II nuclear envelope reassembly
def: "The reformation of the nuclear envelope during meiosis II." [GOC:ai]
is_a: CCO:P0000277 ! meiotic nuclear envelope reassembly
relationship: part_of CCO:P0000112 ! meiosis II
xref: GO:0051335

[Term]
id: CCO:P0000280
name: interphase microtubule nucleation by interphase microtubule organizing center
def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai]
relationship: part_of CCO:P0000269 ! interphase
synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT []
synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT []
synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT []
synonym: "microtubule nucleation during interphase by IMTOC" EXACT []
synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT []
xref: GO:0051415

[Term]
id: CCO:P0000281
name: negative regulation of ubiquitin ligase activity during mitotic cell cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai]
is_a: CCO:P0000283 ! regulation of ubiquitin ligase activity during mitotic cell cycle
synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW []
synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW []
synonym: "APC inhibition during mitotic cell cycle" NARROW []
synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "mitotic anaphase promoting complex inhibition" NARROW []
synonym: "mitotic anaphase promoting complex inhibitor" NARROW []
synonym: "mitotic anaphase-promoting complex inhibition" NARROW []
synonym: "mitotic anaphase-promoting complex inhibitor" NARROW []
synonym: "mitotic APC inhibition" NARROW []
synonym: "mitotic APC inhibitor" NARROW []
synonym: "mitotic SCF complex inhibitor" NARROW []
synonym: "mitotic ubiquitin ligase inhibitor" NARROW []
xref: GO:0051436

[Term]
id: CCO:P0000282
name: positive regulation of ubiquitin ligase activity during mitotic cell cycle
def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai]
is_a: CCO:P0000283 ! regulation of ubiquitin ligase activity during mitotic cell cycle
synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "mitotic SCF complex activator" NARROW []
synonym: "mitotic ubiquitin ligase activator" NARROW []
synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
xref: GO:0051437

[Term]
id: CCO:P0000283
name: regulation of ubiquitin ligase activity during mitotic cell cycle
def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000037 ! mitotic cell cycle
synonym: "mitotic ubiquitin ligase regulator" RELATED []
synonym: "mitotic ubiquitin-protein ligase regulator" RELATED []
synonym: "regulation of ubiquitin-protein ligase activity during mitotic cell cycle" EXACT []
synonym: "mitotic anaphase-promoting complex regulator" NARROW []
synonym: "mitotic APC regulator" NARROW []
synonym: "mitotic SCF complex regulator" NARROW []
xref: GO:0051439

[Term]
id: CCO:P0000284
name: regulation of ubiquitin ligase activity during meiotic cell cycle
def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [EC:6.3.2.19, GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000265 ! meiotic cell cycle
synonym: "meiotic ubiquitin ligase regulator" RELATED []
synonym: "meiotic ubiquitin-protein ligase regulator" RELATED []
synonym: "regulation of ubiquitin-protein ligase activity during meiotic cell cycle" EXACT []
synonym: "meiotic anaphase-promoting complex regulator" NARROW []
synonym: "meiotic APC regulator" NARROW []
synonym: "meiotic SCF complex regulator" NARROW []
xref: GO:0051440

[Term]
id: CCO:P0000285
name: positive regulation of ubiquitin ligase activity during meiotic cell cycle
def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai]
is_a: CCO:P0000284 ! regulation of ubiquitin ligase activity during meiotic cell cycle
synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "meiotic SCF complex activator" NARROW []
synonym: "meiotic ubiquitin ligase activator" NARROW []
synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
xref: GO:0051441

[Term]
id: CCO:P0000286
name: negative regulation of ubiquitin ligase activity during meiotic cell cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai]
is_a: CCO:P0000284 ! regulation of ubiquitin ligase activity during meiotic cell cycle
synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW []
synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW []
synonym: "APC inhibition during meiotic cell cycle" NARROW []
synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "meiotic anaphase promoting complex inhibition" NARROW []
synonym: "meiotic anaphase promoting complex inhibitor" NARROW []
synonym: "meiotic anaphase-promoting complex inhibition" NARROW []
synonym: "meiotic anaphase-promoting complex inhibitor" NARROW []
synonym: "meiotic APC inhibition" NARROW []
synonym: "meiotic APC inhibitor" NARROW []
synonym: "meiotic SCF complex inhibitor" NARROW []
synonym: "meiotic ubiquitin ligase inhibitor" NARROW []
xref: GO:0051442

[Term]
id: CCO:P0000287
name: regulation of progression through meiotic cell cycle
def: "Any process that modulates the rate or extent of progression through the mitotic cell cycle." [GOC:ai]
is_a: CCO:P0000004 ! regulation of progression through cell cycle
relationship: part_of CCO:P0000265 ! meiotic cell cycle
synonym: "meiotic cell cycle regulator" RELATED []
synonym: "control of meiotic cell cycle progression" EXACT []
synonym: "meiotic cell cycle control" EXACT []
synonym: "meiotic cell cycle modulation" EXACT []
synonym: "meiotic cell cycle regulation" EXACT []
synonym: "modulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of meiotic cell cycle" EXACT []
synonym: "regulation of meiotic cell cycle progression" EXACT []
xref: GO:0051445

[Term]
id: CCO:P0000288
name: positive regulation of progression through meiotic cell cycle
def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai]
is_a: CCO:P0000199 ! positive regulation of progression through cell cycle
is_a: CCO:P0000287 ! regulation of progression through meiotic cell cycle
synonym: "positive regulation of meiotic cell cycle progression" EXACT []
synonym: "up regulation of progression through meiotic cell cycle" EXACT []
synonym: "up-regulation of progression through meiotic cell cycle" EXACT []
synonym: "upregulation of progression through meiotic cell cycle" EXACT []
synonym: "activation of progression through meiotic cell cycle" NARROW []
synonym: "stimulation of progression through meiotic cell cycle" NARROW []
xref: GO:0051446

[Term]
id: CCO:P0000289
name: negative regulation of progression through meiotic cell cycle
def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai]
is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
is_a: CCO:P0000287 ! regulation of progression through meiotic cell cycle
synonym: "down regulation of progression through meiotic cell cycle" EXACT []
synonym: "down-regulation of progression through meiotic cell cycle" EXACT []
synonym: "downregulation of progression through meiotic cell cycle" EXACT []
synonym: "negative regulation of meiotic cell cycle progression" EXACT []
synonym: "inhibition of progression through meiotic cell cycle" NARROW []
xref: GO:0051447

[Term]
id: CCO:P0000290
name: attachment of spindle microtubules to kinetochore during meiosis I
def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt]
is_a: CCO:P0000260 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation
relationship: part_of CCO:P0000191 ! homologous chromosome segregation
synonym: "monopolar attachment" EXACT []
synonym: "sister kinetochore monoorientation" EXACT []
comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis.
xref: GO:0051455

[Term]
id: CCO:P0000291
name: attachment of spindle microtubules to kinetochore during meiosis II
def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt]
is_a: CCO:P0000260 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation
relationship: part_of CCO:P0000192 ! meiotic sister chromatid segregation
xref: GO:0051456

[Term]
id: CCO:P0000292
name: anaphase-promoting complex activation during meiotic cell cycle
def: "Any process that initiatiates the ubiquitin ligase activity of the anaphase-promoting complex during the meiotic cell cycle." [GOC:mah, PMID:10871297]
is_a: CCO:P0000285 ! positive regulation of ubiquitin ligase activity during meiotic cell cycle
synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" EXACT []
synonym: "anaphase promoting complex activation during meiotic cell cycle" EXACT []
synonym: "APC activation during meiotic cell cycle" EXACT []
synonym: "meiotic anaphase promoting complex activation" EXACT []
synonym: "meiotic APC activation" EXACT []
synonym: "meiotic anaphase promoting complex activator" NARROW []
synonym: "meiotic anaphase-promoting complex activator" NARROW []
synonym: "meiotic APC activator" NARROW []
xref: GO:0051487

[Term]
id: CCO:P0000293
name: meiotic recombination checkpoint
def: "A checkpoint during late prophase I (pachytene) which prevents segregation of homologous chromosomes until recombination is completed and ensures proper distribution of the genetic material to the gametes." [PMID:14718568]
is_a: CCO:P0000005 ! cell cycle checkpoint
is_a: CCO:P0000200 ! negative regulation of meiosis
relationship: part_of CCO:P0000105 ! meiotic prophase I
synonym: "pachytene checkpoint" EXACT []
xref: GO:0051598

[Term]
id: CCO:P0000294
name: regulation of cell cycle
def: "A cell cycle process that modulates the rate, extent or mode of the cell cycle." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
synonym: "cell cycle control" EXACT []
synonym: "cell cycle modulation" EXACT []
synonym: "cell cycle regulation" EXACT []
xref: GO:0051726

[Term]
id: CCO:P0000295
name: cell cycle switching, meiotic to mitotic cell cycle
def: "The process by which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai]
is_a: CCO:P0000294 ! regulation of cell cycle
synonym: "conversion to mitotic cell cycle" EXACT []
synonym: "entry into mitotic cell cycle" EXACT []
synonym: "initiation of mitotic cell cycle" EXACT []
synonym: "cell cycle switching, meiotis to mitosis" NARROW []
synonym: "conversion to mitosis" NARROW []
synonym: "entry into mitosis" NARROW []
synonym: "initiation of mitosis" NARROW []
synonym: "mitotic entry" NARROW []
xref: GO:0051727

[Term]
id: CCO:P0000296
name: cell cycle switching, mitotic to meiotic cell cycle
def: "The process by which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai]
is_a: CCO:P0000294 ! regulation of cell cycle
synonym: "conversion to meiotic cell cycle" EXACT []
synonym: "entry into meiotic cell cycle" EXACT []
synonym: "initiation of meiotic cell cycle" EXACT []
synonym: "cell cycle switching, mitotis to meiosis" NARROW []
synonym: "conversion to meiosis" NARROW []
synonym: "entry into meiosis" NARROW []
synonym: "initiation of meiosis" NARROW []
synonym: "meiotic entry" NARROW []
xref: GO:0051728
xref: GO:0042061

[Term]
id: CCO:P0000297
name: germline cell cycle switching, mitotic to meiotic cell cycle
def: "The process by which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai]
is_a: CCO:P0000296 ! cell cycle switching, mitotic to meiotic cell cycle
synonym: "germline conversion to meiotic cell cycle" EXACT []
synonym: "germline entry into meiotic cell cycle" EXACT []
synonym: "germline initiation of meiotic cell cycle" EXACT []
synonym: "germline cell cycle switching, mitotis to meiosis" NARROW []
synonym: "germline conversion to meiosis" NARROW []
synonym: "germline entry into meiosis" NARROW []
synonym: "germline initiation of meiosis" NARROW []
synonym: "germline meiotic entry" NARROW []
xref: GO:0051729

[Term]
id: CCO:P0000298
name: meiotic sister chromatid cohesion, centromeric
def: "The cell cycle process whereby centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000240 ! meiotic sister chromatid cohesion
synonym: "meiotic sister chromatid cohesion at centromere" EXACT []
synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT []
xref: GO:0051754

[Term]
id: CCO:P0000299
name: meiotic sister chromatid arm separation
def: "The cell cycle process whereby sister chromatid arms are physically detached from each other during meiosis." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000104 ! meiosis I
relationship: part_of CCO:P0000301 ! meiotic sister chromatid separation
xref: GO:0051755

[Term]
id: CCO:P0000300
name: meiotic sister chromatid centromere separation
def: "The cell cycle process whereby the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000192 ! meiotic sister chromatid segregation
relationship: part_of CCO:P0000301 ! meiotic sister chromatid separation
xref: GO:0051756

[Term]
id: CCO:P0000301
name: meiotic sister chromatid separation
def: "The process by which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
is_a: CCO:P0000254 ! meiotic chromosome separation
xref: GO:0051757

[Term]
id: CCO:P0000302
name: homologous chromosome movement towards spindle pole during meiosis I
def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I." [GOC:ai]
is_a: CCO:P0000134 ! meiotic chromosome movement towards spindle pole
relationship: part_of CCO:P0000191 ! homologous chromosome segregation
synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT []
xref: GO:0051758

[Term]
id: CCO:P0000303
name: sister chromosome movement towards spindle pole during meiosis II
def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai]
is_a: CCO:P0000134 ! meiotic chromosome movement towards spindle pole
relationship: part_of CCO:P0000192 ! meiotic sister chromatid segregation
synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT []
xref: GO:0051759

[Term]
id: CCO:P0000304
name: meiotic sister chromatid cohesion, arms
def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000240 ! meiotic sister chromatid cohesion
synonym: "meiotic sister chromatid cohesion along arms" EXACT []
synonym: "sister chromatid cohesion along arms at meiosis I" EXACT []
xref: GO:0051760

[Term]
id: CCO:P0000305
name: lateral element assembly
def: "The cell cycle process whereby lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847]
is_a: CCO:P0000308 ! cell cycle process
relationship: part_of CCO:P0000107 ! synaptonemal complex assembly
xref: GO:0051878

[Term]
id: CCO:P0000306
name: maintenance of contractile ring localization
def: "The processes by which a contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah]
relationship: part_of CCO:P0000153 ! cytokinesis, contractile ring maintenance
synonym: "cytokinetic ring anchoring" RELATED []
xref: GO:0032189

[Term]
id: CCO:P0000307
name: cell cycle arrest of committed forebrain neuronal progenitor cell
def: "The process by which progression through the cell cycle is halted in a cell that has been committed to become a neuron that will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
is_a: CCO:P0000057 ! cell cycle arrest
comment: This term was added by GO_REF:0000021.
xref: GO:0021883

[Term]
id: CCO:P0000308
name: cell cycle process
def: "A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:isa_complete]
relationship: part_of CCO:P0000056 ! cell cycle
xref: GO:0022402

[Term]
id: CCO:P0000309
name: cell cycle phase
def: "A cell cycle process composed of one of the morphological steps through which a cell progresses during successive cell replication or nuclear replication events." [GOC:isa_complete]
is_a: CCO:P0000308 ! cell cycle process
xref: GO:0022403

[Term]
id: CCO:P0000310
name: spindle elongation
def: "The cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
xref: GO:0051231

[Term]
id: CCO:P0000311
name: spindle midzone assembly
def: "The cell cycle process whereby spindle midzone is formed. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
is_a: CCO:P0000308 ! cell cycle process
synonym: "spindle midzone biogenesis" EXACT []
synonym: "spindle midzone biosynthesis" EXACT []
synonym: "spindle midzone formation" EXACT []
xref: GO:0051255

[Term]
id: CCO:P0000312
name: chromosome separation
def: "The cell cycle process whereby paired chromosomes are detached from each other. In budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions." [GOC:ai]
is_a: CCO:P0000308 ! cell cycle process
xref: GO:0051304

[Term]
id: CCO:P0000313
name: distributive segregation
def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over -- either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) -- but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart]
is_a: CCO:P0000189 ! meiotic chromosome segregation
xref: GO:0032837

[Term]
id: CCO:P0000314
name: regulation of spindle elongation
def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:mah]
relationship: part_of CCO:P0000310 ! spindle elongation
xref: GO:0032887

[Term]
id: CCO:P0000315
name: regulation of mitotic spindle elongation
def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the mitotic spindle." [GOC:mah]
is_a: CCO:P0000314 ! regulation of spindle elongation
relationship: part_of CCO:P0000001 ! mitotic spindle elongation
xref: GO:0032888

[Term]
id: CCO:T0000001
name: Tetrapoda organism
is_a: CCO:T0000050 ! Sarcopterygii organism
xref: NCBI:32523

[Term]
id: CCO:T0000002
name: Ascomycota organism
is_a: CCO:T0000025 ! Fungi organism
xref: NCBI:4890

[Term]
id: CCO:T0000003
name: Theria organism
is_a: CCO:T0000055 ! Mammalia organism
xref: NCBI:32525

[Term]
id: CCO:T0000004
name: Homo sapiens organism
is_a: CCO:T0000052 ! Homo organism
xref: NCBI:9606

[Term]
id: CCO:T0000005
name: Coelomata organism
is_a: CCO:T0000035 ! Bilateria organism
xref: NCBI:33316

[Term]
id: CCO:T0000006
name: Euteleostomi organism
is_a: CCO:T0000026 ! Teleostomi organism
xref: NCBI:117571

[Term]
id: CCO:T0000007
name: rosids organism
is_a: CCO:T0000037 ! core eudicotyledons organism
xref: NCBI:71275

[Term]
id: CCO:T0000008
name: Schizosaccharomyces organism
is_a: CCO:T0000054 ! Schizosaccharomycetaceae organism
xref: NCBI:4895

[Term]
id: CCO:T0000009
name: Streptophyta organism
is_a: CCO:T0000012 ! Viridiplantae organism
xref: NCBI:35493

[Term]
id: CCO:T0000010
name: Magnoliophyta organism
is_a: CCO:T0000031 ! Spermatophyta organism
xref: NCBI:3398

[Term]
id: CCO:T0000011
name: organism
is_a: CCO:U0000001 ! cell-cycle continuant
xref: NCBI:1

[Term]
id: CCO:T0000012
name: Viridiplantae organism
is_a: CCO:T0000032 ! Eukaryota organism
xref: NCBI:33090

[Term]
id: CCO:T0000013
name: Schizosaccharomycetales organism
is_a: CCO:T0000024 ! Schizosaccharomycetes organism
xref: NCBI:34346

[Term]
id: CCO:T0000014
name: Saccharomycetales organism
is_a: CCO:T0000039 ! Saccharomycetes organism
xref: NCBI:4892

[Term]
id: CCO:T0000015
name: eudicotyledons organism
is_a: CCO:T0000010 ! Magnoliophyta organism
xref: NCBI:71240

[Term]
id: CCO:T0000016
name: Saccharomyces cerevisiae organism
is_a: CCO:T0000019 ! Saccharomyces organism
xref: NCBI:4932

[Term]
id: CCO:T0000017
name: Schizosaccharomyces pombe organism
is_a: CCO:T0000008 ! Schizosaccharomyces organism
xref: NCBI:4896

[Term]
id: CCO:T0000018
name: Euphyllophyta organism
is_a: CCO:T0000030 ! Tracheophyta organism
xref: NCBI:78536

[Term]
id: CCO:T0000019
name: Saccharomyces organism
is_a: CCO:T0000034 ! Saccharomycetaceae organism
xref: NCBI:4930

[Term]
id: CCO:T0000020
name: Metazoa organism
is_a: CCO:T0000041 ! Fungi/Metazoa group organism
xref: NCBI:33208

[Term]
id: CCO:T0000021
name: Homo/Pan/Gorilla group organism
is_a: CCO:T0000058 ! Hominidae organism
xref: NCBI:207598

[Term]
id: CCO:T0000022
name: Brassicales organism
is_a: CCO:T0000060 ! eurosids II organism
xref: NCBI:3699

[Term]
id: CCO:T0000023
name: Embryophyta organism
is_a: CCO:T0000051 ! Streptophytina organism
xref: NCBI:3193

[Term]
id: CCO:T0000024
name: Schizosaccharomycetes organism
is_a: CCO:T0000002 ! Ascomycota organism
xref: NCBI:147554

[Term]
id: CCO:T0000025
name: Fungi organism
is_a: CCO:T0000041 ! Fungi/Metazoa group organism
xref: NCBI:4751

[Term]
id: CCO:T0000026
name: Teleostomi organism
is_a: CCO:T0000049 ! Gnathostomata organism
xref: NCBI:117570

[Term]
id: CCO:T0000027
name: Brassicaceae organism
is_a: CCO:T0000022 ! Brassicales organism
xref: NCBI:3700

[Term]
id: CCO:T0000028
name: Primates organism
is_a: CCO:T0000053 ! Euarchontoglires organism
xref: NCBI:9443

[Term]
id: CCO:T0000029
name: Hominoidea organism
is_a: CCO:T0000046 ! Catarrhini organism
xref: NCBI:314295

[Term]
id: CCO:T0000030
name: Tracheophyta organism
is_a: CCO:T0000023 ! Embryophyta organism
xref: NCBI:58023

[Term]
id: CCO:T0000031
name: Spermatophyta organism
is_a: CCO:T0000018 ! Euphyllophyta organism
xref: NCBI:58024

[Term]
id: CCO:T0000032
name: Eukaryota organism
is_a: CCO:T0000040 ! cellular organisms organism
xref: NCBI:2759

[Term]
id: CCO:T0000033
name: Arabidopsis thaliana organism
is_a: CCO:T0000057 ! Arabidopsis organism
xref: NCBI:3702

[Term]
id: CCO:T0000034
name: Saccharomycetaceae organism
is_a: CCO:T0000014 ! Saccharomycetales organism
xref: NCBI:4893

[Term]
id: CCO:T0000035
name: Bilateria organism
is_a: CCO:T0000048 ! Eumetazoa organism
xref: NCBI:33213

[Term]
id: CCO:T0000036
name: Vertebrata organism
is_a: CCO:T0000044 ! Craniata organism
xref: NCBI:7742

[Term]
id: CCO:T0000037
name: core eudicotyledons organism
is_a: CCO:T0000015 ! eudicotyledons organism
xref: NCBI:91827

[Term]
id: CCO:T0000038
name: Saccharomycotina organism
is_a: CCO:T0000002 ! Ascomycota organism
xref: NCBI:147537

[Term]
id: CCO:T0000039
name: Saccharomycetes organism
is_a: CCO:T0000038 ! Saccharomycotina organism
xref: NCBI:4891

[Term]
id: CCO:T0000040
name: cellular organisms organism
is_a: CCO:T0000011 ! organism
xref: NCBI:131567

[Term]
id: CCO:T0000041
name: Fungi/Metazoa group organism
is_a: CCO:T0000032 ! Eukaryota organism
xref: NCBI:33154

[Term]
id: CCO:T0000042
name: Amniota organism
is_a: CCO:T0000001 ! Tetrapoda organism
xref: NCBI:32524

[Term]
id: CCO:T0000043
name: Deuterostomia organism
is_a: CCO:T0000005 ! Coelomata organism
xref: NCBI:33511

[Term]
id: CCO:T0000044
name: Craniata organism
is_a: CCO:T0000045 ! Chordata organism
xref: NCBI:89593

[Term]
id: CCO:T0000045
name: Chordata organism
is_a: CCO:T0000043 ! Deuterostomia organism
xref: NCBI:7711

[Term]
id: CCO:T0000046
name: Catarrhini organism
is_a: CCO:T0000047 ! Simiiformes organism
xref: NCBI:9526

[Term]
id: CCO:T0000047
name: Simiiformes organism
is_a: CCO:T0000059 ! Haplorrhini organism
xref: NCBI:314293

[Term]
id: CCO:T0000048
name: Eumetazoa organism
is_a: CCO:T0000020 ! Metazoa organism
xref: NCBI:6072

[Term]
id: CCO:T0000049
name: Gnathostomata organism
is_a: CCO:T0000036 ! Vertebrata organism
xref: NCBI:7776

[Term]
id: CCO:T0000050
name: Sarcopterygii organism
is_a: CCO:T0000006 ! Euteleostomi organism
xref: NCBI:8287

[Term]
id: CCO:T0000051
name: Streptophytina organism
is_a: CCO:T0000009 ! Streptophyta organism
xref: NCBI:131221

[Term]
id: CCO:T0000052
name: Homo organism
is_a: CCO:T0000021 ! Homo/Pan/Gorilla group organism
xref: NCBI:9605

[Term]
id: CCO:T0000053
name: Euarchontoglires organism
is_a: CCO:T0000056 ! Eutheria organism
xref: NCBI:314146

[Term]
id: CCO:T0000054
name: Schizosaccharomycetaceae organism
is_a: CCO:T0000013 ! Schizosaccharomycetales organism
xref: NCBI:4894

[Term]
id: CCO:T0000055
name: Mammalia organism
is_a: CCO:T0000042 ! Amniota organism
xref: NCBI:40674

[Term]
id: CCO:T0000056
name: Eutheria organism
is_a: CCO:T0000003 ! Theria organism
xref: NCBI:9347

[Term]
id: CCO:T0000057
name: Arabidopsis organism
is_a: CCO:T0000027 ! Brassicaceae organism
xref: NCBI:3701

[Term]
id: CCO:T0000058
name: Hominidae organism
is_a: CCO:T0000029 ! Hominoidea organism
xref: NCBI:9604

[Term]
id: CCO:T0000059
name: Haplorrhini organism
is_a: CCO:T0000028 ! Primates organism
xref: NCBI:376913

[Term]
id: CCO:T0000060
name: eurosids II organism
is_a: CCO:T0000007 ! rosids organism
xref: NCBI:91836

[Term]
id: CCO:U0000000
name: cell-cycle entity
def: "A process or continuant." [CCO:ea]
synonym: "cell cycle entity" EXACT [CCO:ea]

[Term]
id: CCO:U0000001
name: cell-cycle continuant
def: "Entities which endure, or continue to exist, through time while undergoing different sort of changes, including changes of place." [PMID:15892874]
disjoint_from: CCO:U0000002
is_a: CCO:U0000000 ! cell-cycle entity
synonym: "cell cycle continuant" EXACT [CCO:ea]
synonym: "endurant" EXACT [PMID:15892874]
synonym: "thing" BROAD [PMID:15892874]

[Term]
id: CCO:U0000002
name: cell-cycle process
def: "Entities that unfold themselves in successive temporal phases." [PMID:15892874]
disjoint_from: CCO:U0000001
is_a: CCO:U0000000 ! cell-cycle entity
synonym: "perdurant" EXACT [PMID:15892874]
synonym: "ocurrent" BROAD [PMID:15892874]
synonym: "cell cycle process" EXACT [CCO:ea]

[Term]
id: CCO:U0000003
name: biopolymer
def: "A polymer, such as a protein, nucleic acid, or transcript, ocurring in, or formed by, living systems." [CCO:ea]
is_a: CCO:U0000001 ! cell-cycle continuant
synonym: "bio-polymer" EXACT [CCO:ea]

[Term]
id: CCO:U0000004
name: gene
def: "A locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions and/or other functional sequence regions." [SO:0000704]
disjoint_from: CCO:U0000005
is_a: CCO:U0000003 ! biopolymer
xref: SO:0000704

[Term]
id: CCO:U0000005
name: protein
def: "One or more polypeptides which may, or may not, be covalently bonded, and which assume a native secondary and tertiary structure." [SO:0000358]
disjoint_from: CCO:U0000004
is_a: CCO:U0000003 ! biopolymer
xref: SO:0000358

[Term]
id: CCO:U0000006
name: transcript
def: "An RNA synthesized on a DNA or RNA template by an RNA polymerase." [SO:0000673]
is_a: CCO:U0000003 ! biopolymer
xref: SO:0000673

[Term]
id: CCO:U0000007
name: cell cycle protein
def: "Cell cycle proteins are polymeric macromolecules composed of one or more long chains of amino acids linked by peptide bonds, usually coiled and folded into complex globular or fibrous structures." [CCO:ea]
is_a: CCO:U0000005 ! protein
is_a: CCO:U0000001 ! cell cycle continuant

[Term]
id: CCO:U0000008
name: cell cycle gene
def: "Cell cycle units of heredity which (except for polygenes) may be regarded as the controlling agents in the expression of single phenotypic characters and are usually segments of a chromosome at fixed positions relative to each other." [CCO:ea]
is_a: CCO:U0000004 ! gene
is_a: CCO:U0000001 ! cell cycle continuant

[Term]
id: CCO:U0000009
name: interaction
is_a: CCO:U0000002 ! cell-cycle process

[Term]
id: CCO:U0000010
name: complex
def: "Any distinct chemical species in which two or more identical or nonidentical chemical species are associated." [CCO:ea]
is_a: CCO:U0000001 ! cell-cycle continuant

[Term]
id: CCO:U0000011
name: modified protein
def: "A modified protein" [CCO:ea]
is_a: CCO:U0000005 ! protein

[Term]
id: CCO:Y0000025
name: physical association
is_a: CCO:U0000009 ! interaction

[Term]
id: CCO:U0000030
name: modified protein
def: "A protein which underwent any sort of modification (e.g. phosphorylation)" [CCO:ea]
is_a: CCO:U0000005 ! protein

[Term]
id: CCO:U0000012
name: cell cycle modified protein
def: "A cell cycle protein which underwent any sort of modification (e.g. phosphorylation)" [CCO:ea]
is_a: CCO:U0000011 ! modified protein
is_a: CCO:U0000007 ! cell cycle protein 

[Typedef]
id: adjacent_to
name: adjacent_to
def: "C adjacent to C' if and only if: given any instance c that instantiates C at a time t, there is some c' such that: c' instantiates C' at time t and c and c' are in spatial proximity" [PMID:15892874]
comment: Note that adjacent_to as thus defined is not a symmetric relation, in contrast to its instance-level counterpart. For it can be the case that Cs are in general such as to be adjacent to instances of C1 while no analogous statement holds for C1s in general in relation to instances of C. Examples are: nuclear membrane adjacent_to cytoplasm; seminal vesicle adjacent_to urinary bladder; ovary adjacent_to parietal pelvic peritoneum
is_a: relationship ! relationship
xref: OBO_REL:adjacent_to

[Typedef]
id: agent_in
name: agent_in
is_a: relationship ! relationship
xref: OBO_REL:agent_in

[Typedef]
id: association
name: association
def: "C in association with C' produces C'' if and only if for all c belonging to C and c' belongin to C', exists a c'' (belonging to C'') which is the result of the reversible union between c and c'." [CCO:ea]
comment: Ternary relationship. See http://www.w3.org/TR/swbp-n-aryRelations/ for the OWL equivalent. The dissociation is a reversible splitting into simpler entities.
is_a: relationship ! relationship
xref: CCO_REL:association

[Typedef]
id: catalyses
name: catalyses
def: "C catalyses P if and only if for all c (catalyst) belonging to C, exists a p (belonging to P) which chemical reaction rate is increased by c." [CCO:ea]
comment: C inhibits P if and only if for all c (inhibitor) belonging to C, exists a p (belonging to P) which chemical reaction rate is reduced or prevented by c.
synonym: "activates" EXACT []
is_a: relationship ! relationship
xref: CCO_REL:catalyses

[Typedef]
id: contained_in
name: contained_in
def: "C contained_in C' if and only if: given any instance c that instantiates C at a time t, there is some c' such that: c' instantiates C' at time t and c located_in c' at t, and it is not the case that c *overlaps* c' at t. (c' is a conduit or cavity.)" [PMID:15892874]
comment: Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation.    If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows:    c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t.    The containment relation on the instance level can then be defined (see definition):
is_a: relationship ! relationship
xref: OBO_REL:contained_in

[Typedef]
id: contains
name: contains
is_a: relationship ! relationship
xref: OBO_REL:contains

[Typedef]
id: degradates
name: degradates
def: "C is degradated (into NIL) if and only if for all c belonging to C, exists c', c'', ... (belonging to C', C'', ...) which are the result of any undesired breakdown of c with impairment or loss of its characteristic properties." [CCO:ea]
comment: NIL entity must be created.
synonym: "decomposition" EXACT []
synonym: "catabolism" EXACT []
is_a: relationship ! relationship
xref: CCO_REL:degradates

[Typedef]
id: derived_into
name: derived_into
is_a: relationship ! relationship
is_transitive: true
xref: OBO_REL:derived_into

[Typedef]
id: derives_from
name: derives_from
def: "Derivation on the instance level (*derives_from*) holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. We say that one class C derives_from class C' if instances of C are connected to instances of C' via some chain of instance-level derivation relations. Example: osteocyte derives_from osteoblast. Formally: C derives_immediately_from C' if and only if: given any c and any t, if c instantiates C at time t, then there is some c' and some t', such that c' instantiates C' at t' and t' earlier-than t and c *derives_from* c'. C derives_from C' if and only if: there is an chain of immediate derivation relations connecting C to C'." [PMID:15892874]
comment: Derivation as a relation between instances. The temporal relation of derivation is more complex. Transformation, on the instance level, is just the relation of identity: each adult is identical to some child existing at some earlier time. Derivation on the instance-level is a relation holding between non-identicals. More precisely, it holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. Thus we will have axioms to the effect that from c derives_from c1 we can infer that c and c1 are not identical and that there is some instant of time t such that c1 exists only prior to and c only subsequent to t. We will also be able to infer that the spatial region occupied by c as it begins to exist at t overlaps with the spatial region occupied by c1 as it ceases to exist in the same instant.
is_a: relationship ! relationship
is_transitive: true
xref: OBO_REL:derives_from

[Typedef]
id: encoded_by
name: encoded_by
def: "p is encoded by g where p is a Protein and g a Gene." [CCO:ea]
synonym: "is_produced_by" EXACT [CCO:ea]
synonym: "coded_by" EXACT [CCO:ea]
is_a: relationship ! relationship
xref: CCO_REL:encoded_by

[Typedef]
id: codes_for
name: codes_for
def: "g encodes for p where g a Gene and p is a Protein." [CCO:ea]
synonym: "produces" EXACT [CCO:ea]
synonym: "encodes_for" EXACT [CCO:ea]
is_a: relationship ! relationship
xref: CCO_REL:codes_for

[Typedef]
id: has_agent
name: has_agent
def: "As for has_participant, but with the additional condition that the component instance is causally active in the relevant process" [PMID:15892874]
is_a: relationship ! relationship
xref: OBO_REL:has_agent

[Typedef]
id: has_improper_part
name: has_improper_part
is_a: part_of ! part_of
is_reflexive: true
is_transitive: true
xref: OBO_REL:has_improper_part

[Typedef]
id: has_integral_part
name: has_integral_part
is_a: part_of ! part_of
is_reflexive: true
is_anti_symmetric: true
is_transitive: true
xref: OBO_REL:has_integral_part

[Typedef]
id: has_part
name: has_part
is_a: relationship ! relationship
is_reflexive: true
is_anti_symmetric: true
is_transitive: true
xref: OBO_REL:has_part

[Typedef]
id: has_participant
name: has_participant
def: "P has_participant C if and only if: given any process p that instantiates P there is some continuant c, and some time t, such that: c instantiates C at t and c participates in p at t" [PMID:15892874]
comment: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
is_a: relationship ! relationship
xref: OBO_REL:has_participant

[Typedef]
id: has_proper_part
name: has_proper_part
is_a: part_of ! part_of
is_transitive: true
xref: OBO_REL:has_proper_part

[Typedef]
id: improper_part_of
name: improper_part_of
def: "As for part_of, with the additional constraint that subject and object may be identical" [PMID:15892874]
is_a: part_of ! part_of
is_reflexive: true
is_transitive: true
xref: OBO_REL:improper_part_of

[Typedef]
id: integral_part_of
name: integral_part_of
def: "C integral_part_of C' if and only if: C part_of C' AND C' has_part C" [PMID:15892874]
is_a: part_of ! part_of
is_reflexive: true
is_anti_symmetric: true
is_transitive: true
xref: OBO_REL:integral_part_of

[Typedef]
id: interacts_with
name: interacts_with
def: "C interacts_with C' if and only if for all c belonging to C, exists a c' (belonging to C') which plays a role with c'." [CCO:ea]
is_a: relationship ! relationship
is_symmetric: true
is_transitive: true
xref: CCO_REL:interacts_with

[Typedef]
id: is_a
name: is_a
builtin: true
def: "For continuants: C is_a C' if and only if: given any c that instantiates C at a time t, c instantiates C' at t. For processes: P is_a P' if and only if: that given any p that instantiates P, then p instantiates P'." [PMID:15892874]
comment: The is_a relationship is considered axiomatic by the obo file format specification, and by OWL
synonym: "is_subtype_of" EXACT []
is_reflexive: true
is_anti_symmetric: true
is_transitive: true
xref: OBO_REL:is_a
xref: owl:subClassOf

[Typedef]
id: located_in
name: located_in
def: "C located_in C' if and only if: given any c that instantiates C at a time t, there is some c' such that: c' instantiates C' at time t and c *located_in* c'. (Here *located_in* is the instance-level location relation.)" [PMID:15892874]
comment: Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1.    Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus
is_a: relationship ! relationship
is_reflexive: true
is_transitive: true
xref: OBO_REL:located_in

[Typedef]
id: location_of
name: location_of
is_a: relationship ! relationship
is_reflexive: true
is_transitive: true
xref: OBO_REL:location_of

[Typedef]
id: part_of
name: part_of
def: "For continuants: C part_of C' if and only if: given any c that instantiates C at a time t, there is some c' such that c' instantiates C' at time t, and c *part_of* c' at t. For processes: P part_of P' if and only if: given any p that instantiates P at a time t, there is some p' such that p' instantiates P' at time t, and p *part_of* p' at t. (Here *part_of* is the instance-level part-relation.)" [PMID:15892874]
comment: Parthood as a relation between instances: The primitive instance-level relation p part_of p1 is illustrated in assertions such as: this instance of rhodopsin mediated phototransduction part_of this instance of visual perception.    This relation satisfies at least the following standard axioms of mereology: reflexivity (for all p, p part_of p); anti-symmetry (for all p, p1, if p part_of p1 and p1 part_of p then p and p1 are identical); and transitivity (for all p, p1, p2, if p part_of p1 and p1 part_of p2, then p part_of p2). Analogous axioms hold also for parthood as a relation between spatial regions.    For parthood as a relation between continuants, these axioms need to be modified to take account of the incorporation of a temporal argument. Thus for example the axiom of transitivity for continuants will assert that if c part_of c1 at t and c1 part_of c2 at t, then also c part_of c2 at t.    Parthood as a relation between classes: To define part_of as a relation between classes we again need to distinguish the two cases of continuants and processes, even though the explicit reference to instants of time now falls away. For continuants, we have C part_of C1 if and only if any instance of C at any time is an instance-level part of some instance of C1 at that time, as for example in: cell nucleus part_ of cell.
is_a: relationship ! relationship
is_reflexive: true
is_anti_symmetric: true
is_transitive: true
xref: OBO_REL:part_of

[Typedef]
id: participates_in
name: participates_in
def: "C participates_in P if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea]
is_a: relationship ! relationship
xref: OBO_REL:participates_in
xref: CCO_REL:participates_in

[Typedef]
id: preceded_by
name: preceded_by
def: "P preceded_by P' if and only if: given any process p that instantiates P at a time t, there is some process p' such that p' instantiates P' at time t', and t' is earlier than t. " [PMID:15892874]
comment: An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C.    The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
is_a: relationship ! relationship
is_transitive: true
xref: OBO_REL:preceded_by

[Typedef]
id: precedes
name: precedes
is_a: relationship ! relationship
is_transitive: true
xref: OBO_REL:precedes

[Typedef]
id: proper_part_of
name: proper_part_of
def: "As for part_of, with the additional constraint that subject and object are distinct" [PMID:15892874]
is_a: part_of ! part_of
is_transitive: true
xref: OBO_REL:proper_part_of

[Typedef]
id: relationship
name: relationship
def: "A relationship between two classes (terms). Relationships between classes are expressed in terms of relations on underlying instances." []
xref: OBO_REL:relationship

[Typedef]
id: transformation_of
name: transformation_of
def: "Relation between two classes, in which instances retain their identity yet change their classification by virtue of some kind of transformation. Formally: C transformation_of C' if and only if given any c and any t, if c instantiates C at time t, then for some t', c instantiates C' at t' and t' earlier t, and there is no t2 such that c instantiates C at t2 and c instantiates C' at t2." [PMID:15892874]
comment: When an embryonic oenocyte (a type of insect cell) is transformed into a larval oenocyte, one and the same continuant entity preserves its identity while instantiating distinct classes at distinct times. The class-level relation transformation_of obtains between continuant classes C and C1 wherever each instance of the class C is such as to have existed at some earlier time as an instance of the distinct class C1 (see Figure 2 in paper). This relation is illustrated first of all at the molecular level of granularity by the relation between mature RNA and the pre-RNA from which it is processed, or between (UV-induced) thymine-dimer and thymine dinucleotide. At coarser levels of granularity it is illustrated by the transformations involved in the creation of red blood cells, for example, from reticulocyte to erythrocyte, and by processes of development, for example, from larva to pupa, or from (post-gastrular) embryo to fetus or from child to adult. It is also manifest in pathological transformations, for example, of normal colon into carcinomatous colon. In each such case, one and the same continuant entity instantiates distinct classes at different times in virtue of phenotypic changes.
is_a: relationship ! relationship
is_transitive: true
xref: OBO_REL:transformation_of

[Typedef]
id: transforms_into
name: transforms_into
is_a: relationship ! relationship
is_transitive: true
xref: CCO_REL:transforms_into

[Typedef]
id: has_source
name: has_source
def: "o originates from O where o is a gene or gene product and O an organism." [CCO:ea]
is_a: relationship ! relationship
xref: CCO_REL:has_source

[Typedef]
id: source_of
name: source_of
def: "O source of o where O is an organism and o a gene or gene product." [CCO:ea]
is_a: relationship ! relationship
xref: CCO_REL:source_of

[Typedef]
id: has_function
name: has_function
is_a: relationship ! relationship
xref: OBO_REL:has_function