diff test-data/pre_cco_core.obo @ 0:7568445199b6 draft default tip

planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/onto-toolkit commit 9422f839ae354d4c26b02d4494abdeaad518d0e6

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+++ b/test-data/pre_cco_core.obo	Fri Nov 10 11:34:31 2017 -0500
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+format-version: 1.2
+date: 16:02:2007 16:06
+default-namespace: CCO
+autogenerated-by: ONTO-PERL
+remark: The Cell-Cycle Ontology
+
+[Term]
+id: CCO:B0000000
+name: core cell cycle protein
+def: "A protein being considered as principal in the regulation of the cell cycle process" [CCO:cco_team]
+is_a: CCO:U0000005 ! protein
+
+[Term]
+id: CCO:P0000001
+name: mitotic spindle elongation
+def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah]
+is_a: CCO:P0000310 ! spindle elongation
+relationship: part_of CCO:P0000058 ! mitotic spindle organization and biogenesis
+synonym: "spindle elongation during mitosis" EXACT []
+xref: GO:0000022
+
+[Term]
+id: CCO:P0000002
+name: mitotic sister chromatid segregation
+def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000069 ! mitosis
+synonym: "mitotic chromosome segregation" EXACT []
+synonym: "mitotic sister-chromatid adhesion release" NARROW []
+xref: GO:0000070
+xref: GO:0016359
+
+[Term]
+id: CCO:P0000003
+name: M phase specific microtubule process
+def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah]
+relationship: part_of CCO:P0000038 ! M phase
+synonym: "M-phase specific microtubule process" EXACT []
+xref: GO:0000072
+
+[Term]
+id: CCO:P0000004
+name: regulation of progression through cell cycle
+def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:go_curators]
+is_a: CCO:P0000294 ! regulation of cell cycle
+synonym: "cell cycle regulator" RELATED []
+synonym: "RHEB small monomeric GTPase activity" RELATED []
+synonym: "tumor suppressor" RELATED []
+synonym: "control of cell cycle progression" EXACT []
+synonym: "modulation of cell cycle progression" EXACT []
+synonym: "regulation of cell cycle progression" EXACT []
+xref: Reactome:156678
+xref: Reactome:156699
+xref: Reactome:156711
+xref: Reactome:162657
+xref: Reactome:165167
+xref: Reactome:167104
+xref: Reactome:167109
+xref: Reactome:169311
+xref: Reactome:171117
+xref: Reactome:171122
+xref: Reactome:174455
+xref: Reactome:177752
+xref: Reactome:177757
+xref: GO:0000074
+
+[Term]
+id: CCO:P0000005
+name: cell cycle checkpoint
+def: "A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, ISBN:0815316194]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+xref: Reactome:69620
+xref: GO:0000075
+
+[Term]
+id: CCO:P0000006
+name: DNA replication checkpoint
+def: "A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:rn, PMID:11728327, PMID:12537518]
+is_a: CCO:P0000157 ! DNA integrity checkpoint
+xref: GO:0000076
+
+[Term]
+id: CCO:P0000007
+name: DNA damage checkpoint
+def: "A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds." [PMID:11891124]
+is_a: CCO:P0000157 ! DNA integrity checkpoint
+synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW []
+xref: GO:0000077
+
+[Term]
+id: CCO:P0000008
+name: cell morphogenesis checkpoint
+def: "A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective." [GOC:vw, PMID:14644188]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+xref: GO:0000078
+
+[Term]
+id: CCO:P0000009
+name: regulation of cyclin-dependent protein kinase activity
+def: "Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+synonym: "regulation of CDK activity" EXACT []
+xref: GO:0000079
+
+[Term]
+id: CCO:P0000010
+name: G1 phase of mitotic cell cycle
+def: "Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis." [ISBN:0815316194]
+is_a: CCO:P0000262 ! G1 phase
+relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
+xref: Reactome:69236
+xref: GO:0000080
+
+[Term]
+id: CCO:P0000011
+name: G1/S transition of mitotic cell cycle
+def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
+xref: Reactome:69206
+xref: GO:0000082
+
+[Term]
+id: CCO:P0000012
+name: G1/S-specific transcription in mitotic cell cycle
+def: "Any process that regulates transcription such that the target genes are transcribed during the G1/S phase of the mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000011 ! G1/S transition of mitotic cell cycle
+xref: Reactome:69205
+xref: GO:0000083
+
+[Term]
+id: CCO:P0000013
+name: S phase of mitotic cell cycle
+def: "Progression through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place." [ISBN:0815316194]
+is_a: CCO:P0000264 ! S phase
+relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
+xref: GO:0000084
+
+[Term]
+id: CCO:P0000014
+name: G2 phase of mitotic cell cycle
+def: "Progression through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis." [ISBN:0815316194]
+is_a: CCO:P0000263 ! G2 phase
+relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
+xref: Reactome:68911
+xref: GO:0000085
+
+[Term]
+id: CCO:P0000015
+name: G2/M transition of mitotic cell cycle
+def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
+xref: Reactome:69275
+xref: GO:0000086
+
+[Term]
+id: CCO:P0000016
+name: M phase of mitotic cell cycle
+def: "Progression through M phase, the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:mah, ISBN:0815316194]
+is_a: CCO:P0000038 ! M phase
+relationship: part_of CCO:P0000037 ! mitotic cell cycle
+synonym: "M-phase of mitotic cell cycle" EXACT []
+xref: Reactome:68886
+xref: GO:0000087
+
+[Term]
+id: CCO:P0000017
+name: mitotic prophase
+def: "Progression through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle." [ISBN:0815316194]
+is_a: CCO:P0000268 ! prophase
+relationship: part_of CCO:P0000069 ! mitosis
+xref: Reactome:68875
+xref: GO:0000088
+
+[Term]
+id: CCO:P0000018
+name: mitotic metaphase
+def: "Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles." [ISBN:0815316194]
+is_a: CCO:P0000267 ! metaphase
+relationship: part_of CCO:P0000069 ! mitosis
+xref: Reactome:68879
+xref: GO:0000089
+
+[Term]
+id: CCO:P0000019
+name: mitotic anaphase
+def: "Progression through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [ISBN:0815316194]
+is_a: CCO:P0000266 ! anaphase
+relationship: part_of CCO:P0000069 ! mitosis
+xref: Reactome:68882
+xref: GO:0000090
+
+[Term]
+id: CCO:P0000020
+name: mitotic anaphase A
+def: "Progression through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [ISBN:0815316194]
+is_a: CCO:P0000019 ! mitotic anaphase
+xref: GO:0000091
+
+[Term]
+id: CCO:P0000021
+name: mitotic anaphase B
+def: "Progression through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [ISBN:0815316194]
+is_a: CCO:P0000019 ! mitotic anaphase
+xref: GO:0000092
+
+[Term]
+id: CCO:P0000022
+name: mitotic telophase
+def: "Progression through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [ISBN:0721662544]
+is_a: CCO:P0000270 ! telophase
+relationship: part_of CCO:P0000069 ! mitosis
+xref: GO:0000093
+
+[Term]
+id: CCO:P0000023
+name: G1-specific transcription in mitotic cell cycle
+def: "Any process that regulates transcription such that the target genes are transcribed during the G1 phase of the mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000010 ! G1 phase of mitotic cell cycle
+xref: GO:0000114
+
+[Term]
+id: CCO:P0000024
+name: S-phase-specific transcription in mitotic cell cycle
+def: "A cell cycle process that regulates transcription such that the target genes are transcribed during the S phase of the mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000013 ! S phase of mitotic cell cycle
+synonym: "S-specific transcription in mitotic cell cycle" EXACT []
+xref: Reactome:69241
+xref: GO:0000115
+
+[Term]
+id: CCO:P0000025
+name: G2-specific transcription in mitotic cell cycle
+def: "Any process that regulates transcription such that the target genes are transcribed during the G2 phase of the mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000014 ! G2 phase of mitotic cell cycle
+xref: GO:0000116
+
+[Term]
+id: CCO:P0000026
+name: G2/M-specific transcription in mitotic cell cycle
+def: "Any process that regulates transcription such that the target genes are transcribed during the G2/M phase of the mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000015 ! G2/M transition of mitotic cell cycle
+xref: Reactome:69274
+xref: GO:0000117
+
+[Term]
+id: CCO:P0000027
+name: establishment of mitotic spindle orientation
+def: "The processes that set the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
+is_a: CCO:P0000177 ! establishment of mitotic spindle localization
+synonym: "establishment of spindle orientation during mitosis" EXACT []
+synonym: "mitotic spindle orientation" EXACT []
+synonym: "orienting of mitotic spindle" EXACT []
+synonym: "mitotic spindle orientation (sensu Fungi)" NARROW []
+synonym: "mitotic spindle orientation (sensu Saccharomyces)" NARROW []
+xref: GO:0000132
+xref: GO:0030607
+xref: GO:0030609
+
+[Term]
+id: CCO:P0000028
+name: septin checkpoint
+def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+xref: GO:0000135
+
+[Term]
+id: CCO:P0000029
+name: meiotic spindle organization and biogenesis
+def: "The cell cycle process whereby the microtubule spindle is formed and maintained during a meiotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000265 ! meiotic cell cycle
+synonym: "meiotic spindle organisation and biogenesis" EXACT []
+synonym: "spindle organization and biogenesis during meiosis" EXACT []
+xref: GO:0000212
+
+[Term]
+id: CCO:P0000030
+name: M/G1 transition of mitotic cell cycle
+def: "Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000273 ! interphase of mitotic cell cycle
+xref: Reactome:68874
+xref: GO:0000216
+
+[Term]
+id: CCO:P0000031
+name: mitotic prometaphase
+def: "Progression through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mah, ISBN:0198547684]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000069 ! mitosis
+xref: Reactome:68877
+xref: GO:0000236
+
+[Term]
+id: CCO:P0000032
+name: leptotene
+def: "Progression through the first stage of prophase I in meiosis, in which chromosomes first become visible." [ISBN:0198547684]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000105 ! meiotic prophase I
+xref: GO:0000237
+
+[Term]
+id: CCO:P0000033
+name: zygotene
+def: "Progression through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [ISBN:0198547684]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000105 ! meiotic prophase I
+xref: GO:0000238
+
+[Term]
+id: CCO:P0000034
+name: pachytene
+def: "Progression through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [ISBN:0198547684]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000105 ! meiotic prophase I
+xref: GO:0000239
+
+[Term]
+id: CCO:P0000035
+name: diplotene
+def: "Progression through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [ISBN:0198547684]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000105 ! meiotic prophase I
+xref: GO:0000240
+
+[Term]
+id: CCO:P0000036
+name: diakinesis
+def: "Progression through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [ISBN:0198547684]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000105 ! meiotic prophase I
+xref: GO:0000241
+
+[Term]
+id: CCO:P0000037
+name: mitotic cell cycle
+def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M." [GOC:mah, ISBN:0815316194]
+is_a: CCO:P0000056 ! cell cycle
+xref: Reactome:69278
+xref: GO:0000278
+
+[Term]
+id: CCO:P0000038
+name: M phase
+def: "Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis." [ISBN:0815316194]
+is_a: CCO:P0000309 ! cell cycle phase
+synonym: "M-phase" EXACT []
+xref: GO:0000279
+
+[Term]
+id: CCO:P0000039
+name: cytokinesis after mitosis
+def: "The processes resulting in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000016 ! M phase of mitotic cell cycle
+xref: GO:0000281
+
+[Term]
+id: CCO:P0000040
+name: re-entry into mitotic cell cycle
+def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+xref: GO:0000320
+
+[Term]
+id: CCO:P0000041
+name: re-entry into mitotic cell cycle after pheromone arrest
+def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449]
+is_a: CCO:P0000040 ! re-entry into mitotic cell cycle
+synonym: "re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)" NARROW []
+xref: GO:0000321
+
+[Term]
+id: CCO:P0000042
+name: achiasmate meiosis I
+def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419]
+is_a: CCO:P0000104 ! meiosis I
+xref: GO:0000705
+
+[Term]
+id: CCO:P0000043
+name: meiotic DNA double-strand break processing
+def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000054 ! meiotic gene conversion
+relationship: part_of CCO:P0000108 ! meiotic recombination
+xref: GO:0000706
+
+[Term]
+id: CCO:P0000044
+name: meiotic DNA recombinase assembly
+def: "During meiosis, the assembly of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000054 ! meiotic gene conversion
+relationship: part_of CCO:P0000108 ! meiotic recombination
+xref: GO:0000707
+
+[Term]
+id: CCO:P0000045
+name: meiotic strand invasion
+def: "The cell cycle process whereby the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000054 ! meiotic gene conversion
+relationship: part_of CCO:P0000108 ! meiotic recombination
+synonym: "meiotic D-loop biosynthesis" RELATED []
+synonym: "meiotic D-loop formation" RELATED []
+xref: GO:0000708
+
+[Term]
+id: CCO:P0000046
+name: meiotic joint molecule formation
+def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000108 ! meiotic recombination
+xref: GO:0000709
+
+[Term]
+id: CCO:P0000047
+name: meiotic mismatch repair
+def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000054 ! meiotic gene conversion
+relationship: part_of CCO:P0000108 ! meiotic recombination
+xref: GO:0000710
+
+[Term]
+id: CCO:P0000048
+name: meiotic DNA repair synthesis
+def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000054 ! meiotic gene conversion
+relationship: part_of CCO:P0000108 ! meiotic recombination
+xref: GO:0000711
+
+[Term]
+id: CCO:P0000049
+name: resolution of meiotic joint molecules as recombinants
+def: "The cleavage and rejoining of Holliday junctions to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
+is_a: CCO:P0000254 ! meiotic chromosome separation
+relationship: part_of CCO:P0000108 ! meiotic recombination
+relationship: part_of CCO:P0000191 ! homologous chromosome segregation
+synonym: "meiotic homologous chromosome separation" RELATED []
+synonym: "homologous chromosome separation at meiosis I" EXACT []
+synonym: "crossover biosynthesis" NARROW []
+synonym: "crossover formation" NARROW []
+synonym: "formation of chiasmata" NARROW []
+xref: GO:0000712
+
+[Term]
+id: CCO:P0000050
+name: meiotic heteroduplex formation
+def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000054 ! meiotic gene conversion
+xref: GO:0000713
+
+[Term]
+id: CCO:P0000051
+name: meiotic strand displacement
+def: "The cell cycle process whereby the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000054 ! meiotic gene conversion
+xref: GO:0000714
+
+[Term]
+id: CCO:P0000052
+name: cell cycle arrest in response to pheromone
+def: "The processes that lead to a halt in cell cycle progression (cessation of cell cycle transitions) as a result of a pheromone stimulus." [GOC:clt]
+is_a: CCO:P0000057 ! cell cycle arrest
+synonym: "cell cycle arrest (sensu Saccharomyces)" RELATED []
+xref: GO:0000751
+xref: GO:0030571
+
+[Term]
+id: CCO:P0000053
+name: negative regulation of exit from mitosis
+def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn]
+is_a: CCO:P0000095 ! regulation of exit from mitosis
+synonym: "down regulation of exit from mitosis" EXACT []
+synonym: "down-regulation of exit from mitosis" EXACT []
+synonym: "downregulation of exit from mitosis" EXACT []
+synonym: "inhibition of exit from mitosis" NARROW []
+xref: GO:0001100
+
+[Term]
+id: CCO:P0000054
+name: meiotic gene conversion
+def: "The cell cycle process whereby genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000104 ! meiosis I
+synonym: "gene conversion without reciprocal crossover" EXACT []
+xref: GO:0006311
+
+[Term]
+id: CCO:P0000055
+name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
+def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators]
+is_a: CCO:P0000158 ! G1 DNA damage checkpoint
+xref: GO:0006977
+
+[Term]
+id: CCO:P0000056
+name: cell cycle
+def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]
+is_a: CCO:U0000002 ! cell-cycle process
+synonym: "cell-division cycle" EXACT []
+xref: GO:0007049
+
+[Term]
+id: CCO:P0000057
+name: cell cycle arrest
+def: "Any process by which progression through the cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:mah]
+is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
+synonym: "arrest of cell cycle progression" EXACT []
+synonym: "cessation of cell cycle" EXACT []
+synonym: "termination of cell cycle" EXACT []
+xref: GO:0007050
+
+[Term]
+id: CCO:P0000058
+name: mitotic spindle organization and biogenesis
+def: "The cell cycle process whereby the microtubule spindle is formed and maintained during a mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000037 ! mitotic cell cycle
+synonym: "mitotic spindle organisation and biogenesis" EXACT []
+synonym: "spindle organization and biogenesis during mitosis" EXACT []
+xref: GO:0007052
+
+[Term]
+id: CCO:P0000059
+name: male meiotic spindle assembly (sensu Metazoa)
+def: "The formation of the spindle during a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
+is_a: CCO:P0000242 ! meiotic spindle assembly
+relationship: part_of CCO:P0000117 ! male meiosis
+xref: GO:0007053
+
+[Term]
+id: CCO:P0000060
+name: male meiosis I spindle assembly (sensu Metazoa)
+def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
+is_a: CCO:P0000059 ! male meiotic spindle assembly (sensu Metazoa)
+relationship: part_of CCO:P0000118 ! male meiosis I
+xref: GO:0007054
+
+[Term]
+id: CCO:P0000061
+name: male meiosis II spindle assembly (sensu Metazoa)
+def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
+is_a: CCO:P0000059 ! male meiotic spindle assembly (sensu Metazoa)
+relationship: part_of CCO:P0000119 ! male meiosis II
+xref: GO:0007055
+
+[Term]
+id: CCO:P0000062
+name: female meiotic spindle assembly (sensu Metazoa)
+def: "The formation of the spindle during a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
+is_a: CCO:P0000242 ! meiotic spindle assembly
+relationship: part_of CCO:P0000120 ! female meiosis
+xref: GO:0007056
+
+[Term]
+id: CCO:P0000063
+name: female meiosis I spindle assembly (sensu Metazoa)
+def: "The formation of the spindle during meiosis I of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
+is_a: CCO:P0000062 ! female meiotic spindle assembly (sensu Metazoa)
+relationship: part_of CCO:P0000121 ! female meiosis I
+xref: GO:0007057
+
+[Term]
+id: CCO:P0000064
+name: female meiosis II spindle assembly (sensu Metazoa)
+def: "The formation of the spindle during meiosis II of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah]
+is_a: CCO:P0000062 ! female meiotic spindle assembly (sensu Metazoa)
+relationship: part_of CCO:P0000123 ! female meiosis II
+xref: GO:0007058
+
+[Term]
+id: CCO:P0000065
+name: male meiosis chromosome segregation
+def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai]
+is_a: CCO:P0000189 ! meiotic chromosome segregation
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000117 ! male meiosis
+xref: GO:0007060
+
+[Term]
+id: CCO:P0000066
+name: mitotic sister chromatid cohesion
+def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during mitosis. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
+synonym: "mitotic sister-chromatid adhesion release" RELATED []
+xref: GO:0007064
+
+[Term]
+id: CCO:P0000067
+name: male meiosis sister chromatid cohesion
+def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai]
+is_a: CCO:P0000240 ! meiotic sister chromatid cohesion
+relationship: part_of CCO:P0000117 ! male meiosis
+xref: GO:0007065
+
+[Term]
+id: CCO:P0000068
+name: female meiosis sister chromatid cohesion
+def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai]
+is_a: CCO:P0000240 ! meiotic sister chromatid cohesion
+relationship: part_of CCO:P0000120 ! female meiosis
+xref: GO:0007066
+
+[Term]
+id: CCO:P0000069
+name: mitosis
+def: "Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:ma, ISBN:0198547684]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000016 ! M phase of mitotic cell cycle
+xref: GO:0007067
+
+[Term]
+id: CCO:P0000070
+name: negative regulation of transcription, mitotic
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
+is_a: CCO:P0000206 ! regulation of transcription, mitotic
+synonym: "down regulation of transcription, mitotic" EXACT []
+synonym: "down-regulation of transcription, mitotic" EXACT []
+synonym: "downregulation of transcription, mitotic" EXACT []
+synonym: "mitotic repression of transcription" EXACT []
+synonym: "inhibition of transcription, mitotic" NARROW []
+xref: GO:0007068
+
+[Term]
+id: CCO:P0000071
+name: negative regulation of transcription from RNA polymerase I promoter, mitotic
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
+is_a: CCO:P0000070 ! negative regulation of transcription, mitotic
+is_a: CCO:P0000216 ! regulation of transcription from RNA polymerase I promoter, mitotic
+synonym: "down regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
+synonym: "down-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
+synonym: "downregulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
+synonym: "mitotic repression of transcription from Pol I promoter" EXACT []
+synonym: "negative regulation of transcription from Pol I promoter, mitotic" EXACT []
+synonym: "inhibition of transcription from RNA polymerase I promoter, mitotic" NARROW []
+xref: GO:0007069
+
+[Term]
+id: CCO:P0000072
+name: negative regulation of transcription from RNA polymerase II promoter, mitotic
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
+is_a: CCO:P0000070 ! negative regulation of transcription, mitotic
+is_a: CCO:P0000218 ! regulation of transcription from RNA polymerase II promoter, mitotic
+synonym: "down regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
+synonym: "down-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
+synonym: "downregulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
+synonym: "mitotic repression of transcription from Pol II promoter" EXACT []
+synonym: "negative regulation of transcription from Pol II promoter, mitotic" EXACT []
+synonym: "inhibition of transcription from RNA polymerase II promoter, mitotic" NARROW []
+xref: GO:0007070
+
+[Term]
+id: CCO:P0000073
+name: negative regulation of transcription from RNA polymerase III promoter, mitotic
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
+is_a: CCO:P0000070 ! negative regulation of transcription, mitotic
+is_a: CCO:P0000220 ! regulation of transcription from RNA polymerase III promoter, mitotic
+synonym: "down regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
+synonym: "down-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
+synonym: "downregulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
+synonym: "mitotic repression of transcription from Pol III promoter" EXACT []
+synonym: "negative regulation of transcription from Pol III promoter, mitotic" EXACT []
+synonym: "inhibition of transcription from RNA polymerase III promoter, mitotic" NARROW []
+xref: GO:0007071
+
+[Term]
+id: CCO:P0000074
+name: activation of transcription on exit from mitosis
+def: "The cell cycle process whereby transcription is positively regulated as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:isa_complete]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000016 ! M phase of mitotic cell cycle
+xref: GO:0007072
+
+[Term]
+id: CCO:P0000075
+name: activation of transcription on exit from mitosis, from RNA polymerase I promoter
+is_a: CCO:P0000074 ! activation of transcription on exit from mitosis
+synonym: "activation of transcription on exit from mitosis, from Pol I promoter" EXACT []
+xref: GO:0007073
+
+[Term]
+id: CCO:P0000076
+name: activation of transcription on exit from mitosis, from RNA polymerase II promoter
+is_a: CCO:P0000074 ! activation of transcription on exit from mitosis
+synonym: "activation of transcription on exit from mitosis, from Pol II promoter" EXACT []
+xref: GO:0007074
+
+[Term]
+id: CCO:P0000077
+name: activation of transcription on exit from mitosis, from RNA polymerase III promoter
+is_a: CCO:P0000074 ! activation of transcription on exit from mitosis
+synonym: "activation of transcription on exit from mitosis, from Pol III promoter" EXACT []
+xref: GO:0007075
+
+[Term]
+id: CCO:P0000078
+name: mitotic chromosome condensation
+def: "The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
+xref: GO:0007076
+
+[Term]
+id: CCO:P0000079
+name: mitotic nuclear envelope disassembly
+def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000037 ! mitotic cell cycle
+synonym: "mitotic nuclear envelope breakdown" EXACT []
+synonym: "mitotic nuclear envelope catabolism" EXACT []
+synonym: "mitotic nuclear envelope degradation" EXACT []
+xref: GO:0007077
+
+[Term]
+id: CCO:P0000080
+name: lamin depolymerization
+def: "The cell cycle process whereby lamin is depolymerized." [GOC:jic]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000079 ! mitotic nuclear envelope disassembly
+xref: GO:0007078
+
+[Term]
+id: CCO:P0000081
+name: mitotic chromosome movement towards spindle pole
+def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
+synonym: "chromosome migration to spindle pole during mitosis" EXACT []
+synonym: "chromosome movement towards spindle pole during mitosis" EXACT []
+synonym: "mitotic chromosome movement to spindle pole" EXACT []
+synonym: "mitotic sister chromosome movement towards spindle pole" EXACT []
+synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT []
+synonym: "mitotic chromosome movement" BROAD []
+xref: GO:0007079
+xref: GO:0007082
+
+[Term]
+id: CCO:P0000082
+name: mitotic metaphase plate congression
+def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
+xref: GO:0007080
+
+[Term]
+id: CCO:P0000083
+name: mitotic chromosome decondensation
+def: "The cell cycle process whereby chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
+xref: GO:0007083
+
+[Term]
+id: CCO:P0000084
+name: mitotic nuclear envelope reassembly
+def: "The cell cycle process whereby the nuclear envelope reforms during mitotic cell division." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000037 ! mitotic cell cycle
+xref: GO:0007084
+
+[Term]
+id: CCO:P0000085
+name: vesicle fusion with nuclear membrane
+def: "The cell cycle process whereby the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus occurs." [GOC:jic]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000084 ! mitotic nuclear envelope reassembly
+synonym: "vesicle fusion" BROAD []
+xref: GO:0007086
+
+[Term]
+id: CCO:P0000086
+name: mitotic nuclear pore complex reassembly
+def: "The cell cycle process whereby nuclear pore complexes reform during mitotic cell division." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000084 ! mitotic nuclear envelope reassembly
+xref: GO:0007087
+
+[Term]
+id: CCO:P0000087
+name: regulation of mitosis
+def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+relationship: part_of CCO:P0000069 ! mitosis
+xref: Reactome:73674
+xref: GO:0007088
+
+[Term]
+id: CCO:P0000088
+name: traversing start control point of mitotic cell cycle
+def: "Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle." [GOC:mah, ISBN:0815316194]
+is_a: CCO:P0000124 ! regulation of progression through mitotic cell cycle
+relationship: part_of CCO:P0000010 ! G1 phase of mitotic cell cycle
+synonym: "G1 checkpoint" RELATED []
+xref: GO:0007089
+xref: GO:0000081
+
+[Term]
+id: CCO:P0000089
+name: regulation of S phase of mitotic cell cycle
+def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000013 ! S phase of mitotic cell cycle
+relationship: part_of CCO:P0000124 ! regulation of progression through mitotic cell cycle
+xref: GO:0007090
+
+[Term]
+id: CCO:P0000090
+name: mitotic metaphase/anaphase transition
+def: "The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins." [PMID:10465783]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000069 ! mitosis
+xref: Reactome:68881
+xref: GO:0007091
+
+[Term]
+id: CCO:P0000091
+name: anaphase-promoting complex activation during mitotic cell cycle
+def: "Any process that activates, maintains or increases the rate of the ubiquitin ligase activity of the anaphase-promoting complex during the mitotic cell cycle." [GOC:mah, PMID:10871297]
+is_a: CCO:P0000282 ! positive regulation of ubiquitin ligase activity during mitotic cell cycle
+relationship: part_of CCO:P0000139 ! regulation of mitotic metaphase/anaphase transition
+synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during mitotic cell cycle" EXACT []
+synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during mitotic cell cycle" EXACT []
+synonym: "activation of ubiquitin ligase activity of APC during mitotic cell cycle" EXACT []
+synonym: "anaphase promoting complex activation during mitotic cell cycle" EXACT []
+synonym: "APC activation during mitotic cell cycle" EXACT []
+synonym: "mitotic anaphase promoting complex activation" EXACT []
+synonym: "mitotic anaphase-promoting complex activation" EXACT []
+synonym: "mitotic APC activation" EXACT []
+synonym: "mitotic anaphase promoting complex activator" NARROW []
+synonym: "mitotic anaphase-promoting complex activator" NARROW []
+synonym: "mitotic APC activator" NARROW []
+xref: Reactome:162659
+xref: Reactome:163010
+xref: Reactome:165237
+xref: Reactome:166428
+xref: Reactome:169381
+xref: Reactome:170447
+xref: Reactome:173214
+xref: Reactome:173955
+xref: Reactome:176216
+xref: Reactome:177163
+xref: GO:0007092
+
+[Term]
+id: CCO:P0000092
+name: mitotic checkpoint
+def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis." [GOC:rn, PMID:12360190]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+is_a: CCO:P0000087 ! regulation of mitosis
+xref: Reactome:73676
+xref: GO:0007093
+
+[Term]
+id: CCO:P0000093
+name: mitotic spindle checkpoint
+def: "A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly)." [GOC:rn, PMID:12360190]
+is_a: CCO:P0000092 ! mitotic checkpoint
+is_a: CCO:P0000164 ! spindle checkpoint
+synonym: "Mad2-dependent checkpoint" NARROW []
+xref: Reactome:69618
+xref: GO:0007094
+
+[Term]
+id: CCO:P0000094
+name: mitotic G2 checkpoint
+def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA." [GOC:mah, PMID:10856933, PMID:11406266]
+is_a: CCO:P0000092 ! mitotic checkpoint
+is_a: CCO:P0000159 ! G2/M transition DNA damage checkpoint
+synonym: "mitotic G2/M transition DNA damage checkpoint" EXACT []
+xref: GO:0007095
+
+[Term]
+id: CCO:P0000095
+name: regulation of exit from mitosis
+def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]
+is_a: CCO:P0000087 ! regulation of mitosis
+xref: GO:0007096
+
+[Term]
+id: CCO:P0000096
+name: centrosome cycle
+def: "The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
+is_a: CCO:P0000308 ! cell cycle process
+xref: GO:0007098
+
+[Term]
+id: CCO:P0000097
+name: centriole replication
+def: "The cell cycle process whereby a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kva, ISBN:0815316194]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000251 ! centrosome duplication
+synonym: "centriole duplication" EXACT []
+xref: GO:0007099
+
+[Term]
+id: CCO:P0000098
+name: mitotic centrosome separation
+def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]
+is_a: CCO:P0000252 ! centrosome separation
+xref: GO:0007100
+
+[Term]
+id: CCO:P0000099
+name: male meiosis centrosome cycle
+def: "Centrosome duplication and separation in the context of male meiosis." [GOC:mah]
+is_a: CCO:P0000096 ! centrosome cycle
+xref: GO:0007101
+
+[Term]
+id: CCO:P0000100
+name: cytokinesis after meiosis I
+def: "The processes resulting in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
+is_a: CCO:P0000179 ! polar body extrusion after meiotic divisions
+xref: GO:0007110
+
+[Term]
+id: CCO:P0000101
+name: cytokinesis after meiosis II
+def: "The processes resulting in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
+is_a: CCO:P0000179 ! polar body extrusion after meiotic divisions
+xref: GO:0007111
+
+[Term]
+id: CCO:P0000102
+name: endomitotic cell cycle
+def: "The replication and division of chromosomes which is not followed by nuclear division, resulting in an increased number of chromosomes in the cell." [http:www.onelook.com]
+is_a: CCO:P0000056 ! cell cycle
+synonym: "endomitosis" EXACT []
+xref: GO:0007113
+
+[Term]
+id: CCO:P0000103
+name: meiosis
+def: "Progression through meiosis, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiosis occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations." [PMID:9334324]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000271 ! M phase of meiotic cell cycle
+xref: GO:0007126
+
+[Term]
+id: CCO:P0000104
+name: meiosis I
+def: "Progression through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [PMID:9334324]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000103 ! meiosis
+xref: GO:0007127
+
+[Term]
+id: CCO:P0000105
+name: meiotic prophase I
+def: "Progression through prophase of meiosis I; divided into several stages." [GOC:mah]
+is_a: CCO:P0000268 ! prophase
+relationship: part_of CCO:P0000104 ! meiosis I
+xref: GO:0007128
+
+[Term]
+id: CCO:P0000106
+name: synapsis
+def: "The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate." [GOC:elh]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000104 ! meiosis I
+synonym: "homologous chromosome pairing at meiosis" EXACT []
+xref: GO:0007129
+
+[Term]
+id: CCO:P0000107
+name: synaptonemal complex assembly
+def: "The cell cycle process whereby the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000106 ! synapsis
+synonym: "synaptonemal complex formation" EXACT []
+xref: GO:0007130
+
+[Term]
+id: CCO:P0000108
+name: meiotic recombination
+def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000104 ! meiosis I
+synonym: "gene conversion with reciprocal crossover" EXACT []
+synonym: "female meiotic recombination" NARROW []
+xref: GO:0007131
+xref: GO:0000021
+xref: GO:0007145
+
+[Term]
+id: CCO:P0000109
+name: meiotic metaphase I
+def: "Progression through metaphase of meiosis I; analogous to mitotic metaphase." [GOC:mah]
+is_a: CCO:P0000267 ! metaphase
+relationship: part_of CCO:P0000104 ! meiosis I
+xref: GO:0007132
+
+[Term]
+id: CCO:P0000110
+name: meiotic anaphase I
+def: "Progression through anaphase of meiosis I; analogous to mitotic anaphase." [GOC:mah]
+is_a: CCO:P0000266 ! anaphase
+relationship: part_of CCO:P0000104 ! meiosis I
+xref: GO:0007133
+
+[Term]
+id: CCO:P0000111
+name: meiotic telophase I
+def: "Progression through telophase of meiosis I; analogous to mitotic telophase." [GOC:mah]
+is_a: CCO:P0000270 ! telophase
+relationship: part_of CCO:P0000104 ! meiosis I
+xref: GO:0007134
+
+[Term]
+id: CCO:P0000112
+name: meiosis II
+def: "Progression through the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [ISBN:0198547684]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000103 ! meiosis
+xref: GO:0007135
+
+[Term]
+id: CCO:P0000113
+name: meiotic prophase II
+def: "Progression through prophase of meiosis II; analogous to mitotic prophase." [GOC:mah]
+is_a: CCO:P0000268 ! prophase
+relationship: part_of CCO:P0000112 ! meiosis II
+xref: GO:0007136
+
+[Term]
+id: CCO:P0000114
+name: meiotic metaphase II
+def: "Progression through metaphase of meiosis II; analogous to mitotic metaphase." [GOC:mah]
+is_a: CCO:P0000267 ! metaphase
+relationship: part_of CCO:P0000112 ! meiosis II
+xref: GO:0007137
+
+[Term]
+id: CCO:P0000115
+name: meiotic anaphase II
+def: "Progression through anaphase of meiosis II; analogous to mitotic anaphase." [GOC:mah]
+is_a: CCO:P0000266 ! anaphase
+relationship: part_of CCO:P0000112 ! meiosis II
+xref: GO:0007138
+
+[Term]
+id: CCO:P0000116
+name: meiotic telophase II
+def: "Progression through telophase of meiosis II; analogous to mitotic telophase." [GOC:mah]
+is_a: CCO:P0000270 ! telophase
+relationship: part_of CCO:P0000112 ! meiosis II
+xref: GO:0007139
+
+[Term]
+id: CCO:P0000117
+name: male meiosis
+def: "Meiosis in the male germline." [GOC:mah]
+is_a: CCO:P0000103 ! meiosis
+xref: GO:0007140
+
+[Term]
+id: CCO:P0000118
+name: male meiosis I
+def: "Progression through male meiosis I, the first meiotic division in the male germline." [GOC:mah]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000117 ! male meiosis
+xref: GO:0007141
+
+[Term]
+id: CCO:P0000119
+name: male meiosis II
+def: "Progression through male meiosis II, the second meiotic division in the male germline." [GOC:mah]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000117 ! male meiosis
+xref: GO:0007142
+
+[Term]
+id: CCO:P0000120
+name: female meiosis
+def: "Meiosis in the female germline." [GOC:ems]
+is_a: CCO:P0000103 ! meiosis
+comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaprodites such as those of C. elegans. See also the biological process term 'meiosis ; GO:0007126'.
+xref: GO:0007143
+
+[Term]
+id: CCO:P0000121
+name: female meiosis I
+def: "The cell cycle process whereby the first meiotic division occurs in the female germline." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000120 ! female meiosis
+xref: GO:0007144
+
+[Term]
+id: CCO:P0000122
+name: meiotic recombination nodule assembly
+def: "The assembly of small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324]
+is_a: CCO:P0000044 ! meiotic DNA recombinase assembly
+xref: GO:0007146
+
+[Term]
+id: CCO:P0000123
+name: female meiosis II
+def: "The cell cycle process whereby the second meiotic division occurs in the female germline." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000120 ! female meiosis
+xref: GO:0007147
+
+[Term]
+id: CCO:P0000124
+name: regulation of progression through mitotic cell cycle
+def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+relationship: part_of CCO:P0000037 ! mitotic cell cycle
+synonym: "mitotic cell cycle regulator" RELATED []
+synonym: "control of mitotic cell cycle progression" EXACT []
+synonym: "mitotic cell cycle control" EXACT []
+synonym: "mitotic cell cycle modulation" EXACT []
+synonym: "mitotic cell cycle regulation" EXACT []
+synonym: "modulation of mitotic cell cycle progression" EXACT []
+synonym: "regulation of mitotic cell cycle" EXACT []
+synonym: "regulation of mitotic cell cycle progression" EXACT []
+xref: GO:0007346
+
+[Term]
+id: CCO:P0000125
+name: regulation of progression through preblastoderm mitotic cell cycle
+def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000129 ! regulation of progression through embryonic mitotic cell cycle
+relationship: part_of CCO:P0000175 ! preblastoderm mitotic cell cycle
+synonym: "preblastoderm mitotic cell cycle regulator" RELATED []
+synonym: "control of preblastoderm mitotic cell cycle progression" EXACT []
+synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT []
+synonym: "preblastoderm mitotic cell cycle control" EXACT []
+synonym: "preblastoderm mitotic cell cycle modulation" EXACT []
+synonym: "preblastoderm mitotic cell cycle regulation" EXACT []
+synonym: "regulation of preblastoderm mitotic cell cycle" EXACT []
+synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT []
+xref: GO:0007347
+
+[Term]
+id: CCO:P0000126
+name: regulation of progression through syncytial blastoderm mitotic cell cycle
+def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000129 ! regulation of progression through embryonic mitotic cell cycle
+relationship: part_of CCO:P0000176 ! syncytial blastoderm mitotic cell cycle
+synonym: "syncytial blastoderm cell cycle regulator" RELATED []
+synonym: "control of syncytial blastoderm cell cycle progression" EXACT []
+synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT []
+synonym: "regulation of syncytial blastoderm cell cycle" EXACT []
+synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT []
+synonym: "syncytial blastoderm cell cycle control" EXACT []
+synonym: "syncytial blastoderm cell cycle modulation" EXACT []
+synonym: "syncytial blastoderm cell cycle regulation" EXACT []
+xref: GO:0007348
+
+[Term]
+id: CCO:P0000127
+name: cyclin catabolic process
+def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions." [GOC:mah, http:cancerweb.ncl.ac.uk]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+synonym: "cyclin breakdown" EXACT []
+synonym: "cyclin catabolism" EXACT []
+synonym: "cyclin degradation" EXACT []
+synonym: "degradation of cyclin" EXACT []
+xref: GO:0008054
+
+[Term]
+id: CCO:P0000128
+name: meiotic G2/MI transition
+def: "The cell cycle process whereby a cell progresses from meiotic prophase to metaphase I." [PMID:15088480]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000104 ! meiosis I
+xref: GO:0008315
+
+[Term]
+id: CCO:P0000129
+name: regulation of progression through embryonic mitotic cell cycle
+def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:go_curators]
+is_a: CCO:P0000124 ! regulation of progression through mitotic cell cycle
+relationship: part_of CCO:P0000193 ! mitotic cell cycle, embryonic
+synonym: "embryonic mitotic cell cycle regulator" RELATED []
+synonym: "control of embryonic mitotic cell cycle progression" EXACT []
+synonym: "embryonic mitotic cell cycle control" EXACT []
+synonym: "embryonic mitotic cell cycle modulation" EXACT []
+synonym: "embryonic mitotic cell cycle regulation" EXACT []
+synonym: "modulation of embryonic mitotic cell cycle progression" EXACT []
+synonym: "regulation of embryonic mitotic cell cycle" EXACT []
+synonym: "regulation of embryonic mitotic cell cycle progression" EXACT []
+synonym: "regulation of mitotic cell cycle, embryonic" EXACT []
+xref: GO:0009794
+
+[Term]
+id: CCO:P0000130
+name: cell plate formation (sensu Magnoliophyta)
+def: "The cell cycle process whereby the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:tb, ISBN:0879015322]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000069 ! mitosis
+xref: GO:0009920
+
+[Term]
+id: CCO:P0000131
+name: male meiotic spindle assembly (sensu Viridiplantae)
+def: "The formation of the spindle in male meiotic cells. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [PMID:11973272]
+is_a: CCO:P0000242 ! meiotic spindle assembly
+relationship: part_of CCO:P0000117 ! male meiosis
+xref: GO:0009971
+
+[Term]
+id: CCO:P0000132
+name: female meiosis chromosome segregation
+def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
+is_a: CCO:P0000189 ! meiotic chromosome segregation
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000120 ! female meiosis
+xref: GO:0016321
+
+[Term]
+id: CCO:P0000133
+name: second mitotic wave (sensu Endopterygota)
+def: "A discrete cell cycle that occurs during the third instar eye imaginal disc after progression of the morphogenetic furrow. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392)." [PMID:11257224]
+is_a: CCO:P0000056 ! cell cycle
+xref: GO:0016330
+
+[Term]
+id: CCO:P0000134
+name: meiotic chromosome movement towards spindle pole
+def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
+synonym: "chromosome migration to spindle pole during meiosis" EXACT []
+synonym: "chromosome movement towards spindle pole during meiosis" EXACT []
+synonym: "meiotic chromosome movement to spindle pole" EXACT []
+synonym: "meiotic chromosome movement" BROAD []
+xref: GO:0016344
+
+[Term]
+id: CCO:P0000135
+name: female meiotic chromosome movement towards spindle pole
+def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai]
+is_a: CCO:P0000134 ! meiotic chromosome movement towards spindle pole
+relationship: part_of CCO:P0000132 ! female meiosis chromosome segregation
+synonym: "chromosome movement towards spindle pole during female meiosis" EXACT []
+synonym: "female meiotic chromosome movement to spindle pole" EXACT []
+synonym: "female meiotic chromosome movement" BROAD []
+xref: GO:0016345
+
+[Term]
+id: CCO:P0000136
+name: male meiotic chromosome movement towards spindle pole
+def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai]
+is_a: CCO:P0000134 ! meiotic chromosome movement towards spindle pole
+relationship: part_of CCO:P0000065 ! male meiosis chromosome segregation
+synonym: "chromosome movement towards spindle pole during male meiosis" EXACT []
+synonym: "male meiotic chromosome movement to spindle pole" EXACT []
+synonym: "male meiotic chromosome movement" BROAD []
+xref: GO:0016346
+
+[Term]
+id: CCO:P0000137
+name: modification by virus of host cell cycle regulation
+def: "Viral processes that modulate the rate of the host cell cycle to facilitate virus replication." [ISBN:0781718325]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+synonym: "viral perturbation of cell cycle regulation" EXACT []
+xref: GO:0019055
+
+[Term]
+id: CCO:P0000138
+name: actin filament reorganization during cell cycle
+def: "The cell cycle process whereby rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah]
+is_a: CCO:P0000308 ! cell cycle process
+synonym: "actin filament reorganisation during cell cycle" EXACT []
+xref: GO:0030037
+
+[Term]
+id: CCO:P0000139
+name: regulation of mitotic metaphase/anaphase transition
+def: "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000087 ! regulation of mitosis
+relationship: part_of CCO:P0000090 ! mitotic metaphase/anaphase transition
+xref: GO:0030071
+
+[Term]
+id: CCO:P0000140
+name: mitotic spindle organization and biogenesis in nucleus
+def: "The formation and maintenance of the spindle in the nucleus, as seen in Fungi during a mitotic cell cycle." [GOC:mah]
+is_a: CCO:P0000058 ! mitotic spindle organization and biogenesis
+synonym: "mitotic spindle organisation and biogenesis in nucleus" EXACT []
+synonym: "spindle organization and biogenesis in nucleus during mitosis" EXACT []
+synonym: "mitotic spindle assembly (sensu Fungi)" NARROW []
+synonym: "mitotic spindle assembly (sensu Saccharomyces)" NARROW []
+xref: GO:0030472
+xref: GO:0000071
+
+[Term]
+id: CCO:P0000141
+name: horsetail nuclear movement
+def: "The cell cycle process whereby oscillatory movement of the nucleus during meiotic prophase I occurs. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, which may facilitate synapsis necessary for efficient meiotic recombination; as observed in S. pombe." [PMID:16111942, PMID:9572142]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000103 ! meiosis
+synonym: "HNM" EXACT []
+synonym: "horsetail movement" EXACT []
+xref: GO:0030989
+
+[Term]
+id: CCO:P0000142
+name: cell cycle arrest in response to nitrogen starvation
+def: "The processes that lead to a halt in cell cycle progression (cessation of cell cycle transitions) as a result of deprivation of nitrogen." [GOC:vw]
+is_a: CCO:P0000057 ! cell cycle arrest
+xref: GO:0030996
+
+[Term]
+id: CCO:P0000143
+name: regulation of centriole-centriole cohesion
+def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968]
+relationship: part_of CCO:P0000096 ! centrosome cycle
+xref: GO:0030997
+
+[Term]
+id: CCO:P0000144
+name: linear element formation
+def: "The cell cycle process whereby a proteinaceous scaffold, related to the synaptonemal complex, is formed in association with S. pombe chromosomes during meiotic prophase." [GOC:mah, Sanger:jb]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000106 ! synapsis
+xref: GO:0030999
+
+[Term]
+id: CCO:P0000145
+name: septation initiation signaling
+def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the begining of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007]
+is_a: CCO:P0000173 ! regulation of contractile ring contraction during cytokinesis
+synonym: "septation initiation network" EXACT []
+synonym: "septation initiation signalling" EXACT []
+synonym: "SIN" EXACT []
+xref: GO:0031028
+
+[Term]
+id: CCO:P0000146
+name: regulation of septation initiation signaling
+def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah]
+relationship: part_of CCO:P0000145 ! septation initiation signaling
+synonym: "regulation of septation initiation network" EXACT []
+synonym: "regulation of septation initiation signalling" EXACT []
+xref: GO:0031029
+
+[Term]
+id: CCO:P0000147
+name: negative regulation of septation initiation signaling
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah]
+is_a: CCO:P0000146 ! regulation of septation initiation signaling
+synonym: "down regulation of septation initiation signaling" EXACT []
+synonym: "down-regulation of septation initiation signaling" EXACT []
+synonym: "downregulation of septation initiation signaling" EXACT []
+synonym: "negative regulation of septation initiation network" EXACT []
+synonym: "negative regulation of septation initiation signalling" EXACT []
+synonym: "inhibition of septation initiation signaling" NARROW []
+xref: GO:0031030
+
+[Term]
+id: CCO:P0000148
+name: positive regulation of septation initiation signaling
+def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah]
+is_a: CCO:P0000146 ! regulation of septation initiation signaling
+synonym: "positive regulation of septation initiation network" EXACT []
+synonym: "positive regulation of septation initiation signalling" EXACT []
+synonym: "up regulation of septation initiation signaling" EXACT []
+synonym: "up-regulation of septation initiation signaling" EXACT []
+synonym: "upregulation of septation initiation signaling" EXACT []
+synonym: "activation of septation initiation signaling" NARROW []
+synonym: "stimulation of septation initiation signaling" NARROW []
+xref: GO:0031031
+
+[Term]
+id: CCO:P0000149
+name: sister chromatid biorientation
+def: "The cell cycle process whereby sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000082 ! mitotic metaphase plate congression
+synonym: "chromosome biorientation" EXACT []
+synonym: "sister kinetochore biorientation" EXACT []
+xref: GO:0031134
+
+[Term]
+id: CCO:P0000150
+name: collapsed replication fork processing
+def: "The process by which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired by a recombinational mechanism." [PMID:11459955, PMID:15367656]
+relationship: part_of CCO:P0000160 ! intra-S DNA damage checkpoint
+xref: GO:0031297
+
+[Term]
+id: CCO:P0000151
+name: positive regulation of exit from mitosis
+def: "Any processactivates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah]
+is_a: CCO:P0000095 ! regulation of exit from mitosis
+synonym: "up regulation of exit from mitosis" EXACT []
+synonym: "up-regulation of exit from mitosis" EXACT []
+synonym: "upregulation of exit from mitosis" EXACT []
+synonym: "activation of exit from mitosis" NARROW []
+synonym: "stimulation of exit from mitosis" NARROW []
+xref: GO:0031536
+
+[Term]
+id: CCO:P0000152
+name: cytokinesis checkpoint
+def: "A cell cycle checkpoint that ensures the correct temporal ordering of nuclear division and cytokinesis; arrests the cell cycle in G2 upon perturbation of cytokinetic structures. In Schizosaccharomyces, the checkpoint monitors formation and integrity of medial actomyosin ring and septum." [GOC:mah, PMID:15647375]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+synonym: "contractile ring checkpoint" EXACT []
+xref: GO:0031565
+
+[Term]
+id: CCO:P0000153
+name: cytokinesis, contractile ring maintenance
+def: "The cell cycle process whereby the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures." [GOC:vw]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000152 ! cytokinesis checkpoint
+xref: GO:0031566
+
+[Term]
+id: CCO:P0000154
+name: cell size control checkpoint
+def: "Any cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size." [GOC:mah]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+xref: GO:0031567
+
+[Term]
+id: CCO:P0000155
+name: G1/S transition size control checkpoint
+def: "A cell cycle checkpoint that blocks cell cycle progression from G1 to S phase until cells have reached a critical size." [GOC:mah]
+is_a: CCO:P0000154 ! cell size control checkpoint
+is_a: CCO:P0000162 ! G1/S transition checkpoint
+xref: GO:0031568
+
+[Term]
+id: CCO:P0000156
+name: G2/M transition size control checkpoint
+def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until cells have reached a critical size." [GOC:mah]
+is_a: CCO:P0000154 ! cell size control checkpoint
+is_a: CCO:P0000163 ! G2/M transition checkpoint
+xref: GO:0031569
+
+[Term]
+id: CCO:P0000157
+name: DNA integrity checkpoint
+def: "Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure." [GOC:mah, GOC:vw]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+xref: GO:0031570
+
+[Term]
+id: CCO:P0000158
+name: G1 DNA damage checkpoint
+def: "A cell cycle checkpoint that arrests cell cycle progression G1 phase in response to DNA damage." [GOC:mah]
+is_a: CCO:P0000007 ! DNA damage checkpoint
+xref: GO:0031571
+
+[Term]
+id: CCO:P0000159
+name: G2/M transition DNA damage checkpoint
+def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage." [GOC:mah]
+is_a: CCO:P0000007 ! DNA damage checkpoint
+is_a: CCO:P0000163 ! G2/M transition checkpoint
+xref: GO:0031572
+
+[Term]
+id: CCO:P0000160
+name: intra-S DNA damage checkpoint
+def: "The slowing of DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession." [GOC:vw]
+is_a: CCO:P0000007 ! DNA damage checkpoint
+xref: GO:0031573
+
+[Term]
+id: CCO:P0000161
+name: S-M checkpoint
+def: "A cell cycle checkpoint which halts replication in response to nucleotide depletion." [GOC:vw]
+is_a: CCO:P0000160 ! intra-S DNA damage checkpoint
+xref: GO:0031574
+
+[Term]
+id: CCO:P0000162
+name: G1/S transition checkpoint
+def: "Any cell cycle checkpoint that blocks entry into S phase." [GOC:mah]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+xref: GO:0031575
+
+[Term]
+id: CCO:P0000163
+name: G2/M transition checkpoint
+def: "Any cell cycle checkpoint that blocks entry into M phase." [GOC:mah]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+synonym: "G2/M checkpoint" EXACT []
+xref: GO:0031576
+
+[Term]
+id: CCO:P0000164
+name: spindle checkpoint
+def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until all chromosomes are attached to the spindle." [PMID:15897186]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+synonym: "spindle assembly checkpoint" EXACT []
+synonym: "SAC" BROAD []
+xref: GO:0031577
+
+[Term]
+id: CCO:P0000165
+name: spindle orientation checkpoint
+def: "A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected." [GOC:clt, PMID:14616062]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+synonym: "SOC" EXACT []
+synonym: "spindle position checkpoint" EXACT []
+synonym: "SPOC" EXACT []
+xref: GO:0031578
+
+[Term]
+id: CCO:P0000166
+name: homologous chromosome orientation during meiosis
+def: "The cell cycle process whereby the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000183 ! meiotic metaphase I plate congression
+synonym: "homologous chromosome orientation during meiosis I" EXACT []
+xref: GO:0031619
+
+[Term]
+id: CCO:P0000167
+name: G1/S-specific regulation of cyclin-dependent protein kinase activity
+def: "Any process that modulates the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah]
+is_a: CCO:P0000009 ! regulation of cyclin-dependent protein kinase activity
+relationship: part_of CCO:P0000011 ! G1/S transition of mitotic cell cycle
+xref: GO:0031657
+
+[Term]
+id: CCO:P0000168
+name: G1/S-specific negative regulation of cyclin-dependent protein kinase activity
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah]
+is_a: CCO:P0000167 ! G1/S-specific regulation of cyclin-dependent protein kinase activity
+is_a: CCO:P0000194 ! negative regulation of cyclin-dependent protein kinase activity
+synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
+xref: GO:0031658
+
+[Term]
+id: CCO:P0000169
+name: G1/S-specific positive regulation of cyclin-dependent protein kinase activity
+def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah]
+is_a: CCO:P0000167 ! G1/S-specific regulation of cyclin-dependent protein kinase activity
+is_a: CCO:P0000195 ! positive regulation of cyclin-dependent protein kinase activity
+synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW []
+synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW []
+xref: GO:0031659
+
+[Term]
+id: CCO:P0000170
+name: G2/M-specific regulation of cyclin-dependent protein kinase activity
+def: "Any process that modulates the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah]
+is_a: CCO:P0000009 ! regulation of cyclin-dependent protein kinase activity
+relationship: part_of CCO:P0000015 ! G2/M transition of mitotic cell cycle
+xref: GO:0031660
+
+[Term]
+id: CCO:P0000171
+name: G2/M-specific negative regulation of cyclin-dependent protein kinase activity
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah]
+is_a: CCO:P0000170 ! G2/M-specific regulation of cyclin-dependent protein kinase activity
+is_a: CCO:P0000194 ! negative regulation of cyclin-dependent protein kinase activity
+synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
+xref: GO:0031661
+
+[Term]
+id: CCO:P0000172
+name: G2/M-specific positive regulation of cyclin-dependent protein kinase activity
+def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah]
+is_a: CCO:P0000170 ! G2/M-specific regulation of cyclin-dependent protein kinase activity
+is_a: CCO:P0000195 ! positive regulation of cyclin-dependent protein kinase activity
+synonym: "G2/M-specific up regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G2/M-specific up-regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G2/M-specific upregulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "G2/M-specific activation of cyclin-dependent protein kinase activity" NARROW []
+synonym: "G2/M-specific stimulation of cyclin-dependent protein kinase activity" NARROW []
+xref: GO:0031662
+
+[Term]
+id: CCO:P0000173
+name: regulation of contractile ring contraction during cytokinesis
+def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring during cytokinesis." [GOC:mah]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+xref: GO:0031991
+
+[Term]
+id: CCO:P0000174
+name: attachment of telomeres to spindle pole body
+def: "The cell cycle process whereby physical connections are formed between telomeres and the spindle pole body, facilitating bouquet formation." [PMID:16615890]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000190 ! telomere clustering
+xref: GO:0032121
+
+[Term]
+id: CCO:P0000175
+name: preblastoderm mitotic cell cycle
+def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
+is_a: CCO:P0000193 ! mitotic cell cycle, embryonic
+xref: GO:0035185
+
+[Term]
+id: CCO:P0000176
+name: syncytial blastoderm mitotic cell cycle
+def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
+is_a: CCO:P0000193 ! mitotic cell cycle, embryonic
+xref: GO:0035186
+
+[Term]
+id: CCO:P0000177
+name: establishment of mitotic spindle localization
+def: "The cell cycle process whereby the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000037 ! mitotic cell cycle
+synonym: "mitotic spindle positioning" EXACT []
+synonym: "mitotic spindle positioning or orientation" EXACT []
+synonym: "spindle positioning during mitosis" EXACT []
+synonym: "mitotic spindle positioning (sensu Fungi)" NARROW []
+synonym: "mitotic spindle positioning (sensu Saccharomyces)" NARROW []
+synonym: "mitotic spindle positioning and orientation (sensu Saccharomyces)" NARROW []
+synonym: "mitotic spindle positioning or orientation (sensu Fungi)" NARROW []
+xref: GO:0040001
+xref: GO:0018986
+xref: GO:0030605
+xref: GO:0030606
+xref: GO:0030608
+xref: GO:0030610
+
+[Term]
+id: CCO:P0000178
+name: regulation of meiosis
+def: "Any process that modulates the frequency, rate or extent of meiosis, the process by which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+relationship: part_of CCO:P0000103 ! meiosis
+xref: GO:0040020
+
+[Term]
+id: CCO:P0000179
+name: polar body extrusion after meiotic divisions
+def: "The cell cycle process whereby two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000120 ! female meiosis
+xref: GO:0040038
+
+[Term]
+id: CCO:P0000180
+name: meiotic DNA double-strand break formation
+def: "The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000054 ! meiotic gene conversion
+relationship: part_of CCO:P0000108 ! meiotic recombination
+xref: GO:0042138
+
+[Term]
+id: CCO:P0000181
+name: early meiotic recombination nodule assembly
+def: "The assembly of small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324]
+is_a: CCO:P0000122 ! meiotic recombination nodule assembly
+xref: GO:0042139
+
+[Term]
+id: CCO:P0000182
+name: late meiotic recombination nodule assembly
+def: "The assembly of small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324]
+is_a: CCO:P0000122 ! meiotic recombination nodule assembly
+xref: GO:0042140
+
+[Term]
+id: CCO:P0000183
+name: meiotic metaphase I plate congression
+def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666]
+is_a: CCO:P0000257 ! meiotic metaphase plate congression
+relationship: part_of CCO:P0000191 ! homologous chromosome segregation
+xref: GO:0043060
+
+[Term]
+id: CCO:P0000184
+name: meiotic metaphase II plate congression
+def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666]
+is_a: CCO:P0000257 ! meiotic metaphase plate congression
+relationship: part_of CCO:P0000192 ! meiotic sister chromatid segregation
+xref: GO:0043061
+
+[Term]
+id: CCO:P0000185
+name: meiotic spindle stabilization
+def: "The cell cycle process whereby spindle integrity is maintained during M phase of meiosis." [GOC:go_curators]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000029 ! meiotic spindle organization and biogenesis
+xref: GO:0043147
+
+[Term]
+id: CCO:P0000186
+name: mitotic spindle stabilization
+def: "The cell cycle process whereby spindle integrity is maintained during M phase of mitosis." [GOC:go_curators]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000058 ! mitotic spindle organization and biogenesis
+xref: GO:0043148
+
+[Term]
+id: CCO:P0000187
+name: G0 to G1 transition
+def: "The transition from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [ISBN:0716731363]
+is_a: CCO:P0000040 ! re-entry into mitotic cell cycle
+xref: GO:0045023
+
+[Term]
+id: CCO:P0000188
+name: negative regulation of meiotic recombination
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of recombination during meiosis." [GOC:ai]
+is_a: CCO:P0000200 ! negative regulation of meiosis
+relationship: part_of CCO:P0000108 ! meiotic recombination
+synonym: "down regulation of meiotic recombination" EXACT []
+synonym: "down-regulation of meiotic recombination" EXACT []
+synonym: "downregulation of meiotic recombination" EXACT []
+synonym: "suppression of meiotic recombination" EXACT []
+synonym: "inhibition of meiotic recombination" NARROW []
+xref: GO:0045128
+
+[Term]
+id: CCO:P0000189
+name: meiotic chromosome segregation
+def: "The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle." [GOC:ai]
+relationship: part_of CCO:P0000103 ! meiosis
+xref: GO:0045132
+
+[Term]
+id: CCO:P0000190
+name: telomere clustering
+def: "The cell cycle process whereby the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in homologous chromosome pairing and therefore progression through meiosis." [GOC:vw, PMID:10690419]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000103 ! meiosis
+synonym: "bouquet biosynthesis" NARROW []
+synonym: "bouquet formation" NARROW []
+xref: GO:0045141
+
+[Term]
+id: CCO:P0000191
+name: homologous chromosome segregation
+def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000104 ! meiosis I
+relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
+synonym: "meiosis I, chromosome segregation" EXACT []
+xref: GO:0045143
+xref: GO:0007061
+
+[Term]
+id: CCO:P0000192
+name: meiotic sister chromatid segregation
+def: "The cell cycle process whereby sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000112 ! meiosis II
+relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
+synonym: "meiosis II, chromosome segregation" EXACT []
+xref: GO:0045144
+
+[Term]
+id: CCO:P0000193
+name: mitotic cell cycle, embryonic
+def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
+is_a: CCO:P0000037 ! mitotic cell cycle
+xref: GO:0045448
+
+[Term]
+id: CCO:P0000194
+name: negative regulation of cyclin-dependent protein kinase activity
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity." [GOC:go_curators]
+is_a: CCO:P0000009 ! regulation of cyclin-dependent protein kinase activity
+is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
+synonym: "CDK inhibitor" RELATED []
+synonym: "cyclin-dependent kinase inhibitor" RELATED []
+synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "negative regulation of CDK activity" EXACT []
+synonym: "inhibition of cyclin-dependent protein kinase activity" NARROW []
+xref: GO:0045736
+
+[Term]
+id: CCO:P0000195
+name: positive regulation of cyclin-dependent protein kinase activity
+def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators]
+is_a: CCO:P0000009 ! regulation of cyclin-dependent protein kinase activity
+is_a: CCO:P0000199 ! positive regulation of progression through cell cycle
+synonym: "positive regulation of CDK activity" EXACT []
+synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT []
+synonym: "activation of cyclin-dependent protein kinase activity" NARROW []
+synonym: "stimulation of cyclin-dependent protein kinase activity" NARROW []
+xref: GO:0045737
+
+[Term]
+id: CCO:P0000196
+name: negative regulation of S phase of mitotic cell cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
+is_a: CCO:P0000089 ! regulation of S phase of mitotic cell cycle
+is_a: CCO:P0000208 ! negative regulation of progression through mitotic cell cycle
+synonym: "down regulation of S phase of mitotic cell cycle" EXACT []
+synonym: "down-regulation of S phase of mitotic cell cycle" EXACT []
+synonym: "downregulation of S phase of mitotic cell cycle" EXACT []
+synonym: "inhibition of S phase of mitotic cell cycle" NARROW []
+xref: GO:0045749
+
+[Term]
+id: CCO:P0000197
+name: positive regulation of S phase of mitotic cell cycle
+def: "Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
+is_a: CCO:P0000089 ! regulation of S phase of mitotic cell cycle
+is_a: CCO:P0000209 ! positive regulation of progression through mitotic cell cycle
+synonym: "up regulation of S phase of mitotic cell cycle" EXACT []
+synonym: "up-regulation of S phase of mitotic cell cycle" EXACT []
+synonym: "upregulation of S phase of mitotic cell cycle" EXACT []
+synonym: "activation of S phase of mitotic cell cycle" NARROW []
+synonym: "stimulation of S phase of mitotic cell cycle" NARROW []
+xref: GO:0045750
+
+[Term]
+id: CCO:P0000198
+name: negative regulation of progression through cell cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the cell cycle." [GOC:go_curators]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+synonym: "down regulation of progression through cell cycle" EXACT []
+synonym: "down-regulation of progression through cell cycle" EXACT []
+synonym: "downregulation of progression through cell cycle" EXACT []
+synonym: "negative regulation of cell cycle progression" EXACT []
+synonym: "inhibition of progression through cell cycle" NARROW []
+xref: GO:0045786
+
+[Term]
+id: CCO:P0000199
+name: positive regulation of progression through cell cycle
+def: "Any process that activates or increases the frequency, rate or extent of progression through the cell cycle." [GOC:go_curators]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+synonym: "positive regulation of cell cycle progression" EXACT []
+synonym: "up regulation of progression through cell cycle" EXACT []
+synonym: "up-regulation of progression through cell cycle" EXACT []
+synonym: "upregulation of progression through cell cycle" EXACT []
+synonym: "activation of progression through cell cycle" NARROW []
+synonym: "stimulation of progression through cell cycle" NARROW []
+xref: GO:0045787
+
+[Term]
+id: CCO:P0000200
+name: negative regulation of meiosis
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiosis." [GOC:go_curators]
+is_a: CCO:P0000178 ! regulation of meiosis
+synonym: "down regulation of meiosis" EXACT []
+synonym: "down-regulation of meiosis" EXACT []
+synonym: "downregulation of meiosis" EXACT []
+synonym: "inhibition of meiosis" NARROW []
+xref: GO:0045835
+
+[Term]
+id: CCO:P0000201
+name: positive regulation of meiosis
+def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators]
+is_a: CCO:P0000178 ! regulation of meiosis
+synonym: "up regulation of meiosis" EXACT []
+synonym: "up-regulation of meiosis" EXACT []
+synonym: "upregulation of meiosis" EXACT []
+synonym: "activation of meiosis" NARROW []
+synonym: "stimulation of meiosis" NARROW []
+xref: GO:0045836
+
+[Term]
+id: CCO:P0000202
+name: negative regulation of mitosis
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitosis." [GOC:go_curators]
+is_a: CCO:P0000087 ! regulation of mitosis
+is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
+synonym: "down regulation of mitosis" EXACT []
+synonym: "down-regulation of mitosis" EXACT []
+synonym: "downregulation of mitosis" EXACT []
+synonym: "inhibition of mitosis" NARROW []
+xref: GO:0045839
+
+[Term]
+id: CCO:P0000203
+name: positive regulation of mitosis
+def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators]
+is_a: CCO:P0000087 ! regulation of mitosis
+is_a: CCO:P0000199 ! positive regulation of progression through cell cycle
+synonym: "up regulation of mitosis" EXACT []
+synonym: "up-regulation of mitosis" EXACT []
+synonym: "upregulation of mitosis" EXACT []
+synonym: "activation of mitosis" NARROW []
+synonym: "mitogenic activity" NARROW []
+synonym: "stimulation of mitosis" NARROW []
+xref: GO:0045840
+
+[Term]
+id: CCO:P0000204
+name: negative regulation of mitotic metaphase/anaphase transition
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
+is_a: CCO:P0000139 ! regulation of mitotic metaphase/anaphase transition
+is_a: CCO:P0000202 ! negative regulation of mitosis
+synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT []
+synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT []
+synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT []
+synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW []
+xref: GO:0045841
+
+[Term]
+id: CCO:P0000205
+name: positive regulation of mitotic metaphase/anaphase transition
+def: "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
+is_a: CCO:P0000139 ! regulation of mitotic metaphase/anaphase transition
+is_a: CCO:P0000203 ! positive regulation of mitosis
+synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT []
+synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT []
+synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT []
+synonym: "activation of mitotic metaphase/anaphase transition" NARROW []
+synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW []
+xref: GO:0045842
+
+[Term]
+id: CCO:P0000206
+name: regulation of transcription, mitotic
+def: "A cell cycle process that modulates the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000069 ! mitosis
+synonym: "mitotic regulation of transcription" EXACT []
+xref: GO:0045896
+
+[Term]
+id: CCO:P0000207
+name: positive regulation of transcription, mitotic
+def: "Any process that activates or increases the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
+is_a: CCO:P0000206 ! regulation of transcription, mitotic
+synonym: "mitotic activation of transcription" EXACT []
+synonym: "up regulation of transcription, mitotic" EXACT []
+synonym: "up-regulation of transcription, mitotic" EXACT []
+synonym: "upregulation of transcription, mitotic" EXACT []
+synonym: "activation of transcription, mitotic" NARROW []
+synonym: "stimulation of transcription, mitotic" NARROW []
+xref: GO:0045897
+
+[Term]
+id: CCO:P0000208
+name: negative regulation of progression through mitotic cell cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000124 ! regulation of progression through mitotic cell cycle
+is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
+synonym: "down regulation of progression through mitotic cell cycle" EXACT []
+synonym: "down-regulation of progression through mitotic cell cycle" EXACT []
+synonym: "downregulation of progression through mitotic cell cycle" EXACT []
+synonym: "negative regulation of mitotic cell cycle" EXACT []
+synonym: "negative regulation of mitotic cell cycle progression" EXACT []
+synonym: "inhibition of progression through mitotic cell cycle" NARROW []
+xref: GO:0045930
+
+[Term]
+id: CCO:P0000209
+name: positive regulation of progression through mitotic cell cycle
+def: "Any process that activates or increases the frequency, rate or extent of progression through the mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000124 ! regulation of progression through mitotic cell cycle
+is_a: CCO:P0000199 ! positive regulation of progression through cell cycle
+synonym: "positive regulation of mitotic cell cycle" EXACT []
+synonym: "positive regulation of mitotic cell cycle progression" EXACT []
+synonym: "up regulation of progression through mitotic cell cycle" EXACT []
+synonym: "up-regulation of progression through mitotic cell cycle" EXACT []
+synonym: "upregulation of progression through mitotic cell cycle" EXACT []
+synonym: "activation of progression through mitotic cell cycle" NARROW []
+synonym: "stimulation of progression through mitotic cell cycle" NARROW []
+xref: GO:0045931
+
+[Term]
+id: CCO:P0000210
+name: negative regulation of progression through embryonic mitotic cell cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000129 ! regulation of progression through embryonic mitotic cell cycle
+is_a: CCO:P0000208 ! negative regulation of progression through mitotic cell cycle
+synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT []
+synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT []
+synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT []
+synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT []
+synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW []
+xref: GO:0045976
+
+[Term]
+id: CCO:P0000211
+name: positive regulation of mitotic cell cycle, embryonic
+def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000129 ! regulation of progression through embryonic mitotic cell cycle
+is_a: CCO:P0000209 ! positive regulation of progression through mitotic cell cycle
+synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT []
+synonym: "up regulation of mitotic cell cycle, embryonic" EXACT []
+synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT []
+synonym: "upregulation of mitotic cell cycle, embryonic" EXACT []
+synonym: "activation of mitotic cell cycle, embryonic" NARROW []
+synonym: "stimulation of mitotic cell cycle, embryonic" NARROW []
+xref: GO:0045977
+
+[Term]
+id: CCO:P0000212
+name: negative regulation of progression through preblastoderm mitotic cell cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000125 ! regulation of progression through preblastoderm mitotic cell cycle
+is_a: CCO:P0000210 ! negative regulation of progression through embryonic mitotic cell cycle
+synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT []
+synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
+synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT []
+synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT []
+synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW []
+xref: GO:0046001
+
+[Term]
+id: CCO:P0000213
+name: positive regulation of progression through preblastoderm mitotic cell cycle
+def: "Any process that activates or increases the frequency, rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000125 ! regulation of progression through preblastoderm mitotic cell cycle
+is_a: CCO:P0000211 ! positive regulation of mitotic cell cycle, embryonic
+synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT []
+synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT []
+synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
+synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT []
+synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW []
+synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW []
+xref: GO:0046002
+
+[Term]
+id: CCO:P0000214
+name: negative regulation of progression through syncytial blastoderm mitotic cell cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000126 ! regulation of progression through syncytial blastoderm mitotic cell cycle
+is_a: CCO:P0000210 ! negative regulation of progression through embryonic mitotic cell cycle
+synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
+synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
+synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
+synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT []
+synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW []
+xref: GO:0046003
+
+[Term]
+id: CCO:P0000215
+name: positive regulation of progression through syncytial blastoderm mitotic cell cycle
+def: "Any process that activates or increases the frequency, rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:go_curators]
+is_a: CCO:P0000126 ! regulation of progression through syncytial blastoderm mitotic cell cycle
+is_a: CCO:P0000211 ! positive regulation of mitotic cell cycle, embryonic
+synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT []
+synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
+synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
+synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
+synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
+synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
+xref: GO:0046004
+
+[Term]
+id: CCO:P0000216
+name: regulation of transcription from RNA polymerase I promoter, mitotic
+def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000206 ! regulation of transcription, mitotic
+synonym: "mitotic regulation of transcription from Pol I promoter" EXACT []
+synonym: "regulation of transcription from Pol I promoter, mitotic" EXACT []
+xref: GO:0046017
+
+[Term]
+id: CCO:P0000217
+name: positive regulation of transcription from RNA polymerase I promoter, mitotic
+def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
+is_a: CCO:P0000207 ! positive regulation of transcription, mitotic
+is_a: CCO:P0000216 ! regulation of transcription from RNA polymerase I promoter, mitotic
+synonym: "mitotic activation of transcription from Pol I promoter" EXACT []
+synonym: "positive regulation of transcription from Pol I promoter, mitotic" EXACT []
+synonym: "up regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
+synonym: "up-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
+synonym: "upregulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
+synonym: "activation of transcription from RNA polymerase I promoter, mitotic" NARROW []
+synonym: "stimulation of transcription from RNA polymerase I promoter, mitotic" NARROW []
+xref: GO:0046018
+
+[Term]
+id: CCO:P0000218
+name: regulation of transcription from RNA polymerase II promoter, mitotic
+def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000206 ! regulation of transcription, mitotic
+synonym: "mitotic regulation of transcription from Pol II promoter" EXACT []
+synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT []
+xref: GO:0046021
+
+[Term]
+id: CCO:P0000219
+name: positive regulation of transcription from RNA polymerase II promoter, mitotic
+def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
+is_a: CCO:P0000207 ! positive regulation of transcription, mitotic
+is_a: CCO:P0000218 ! regulation of transcription from RNA polymerase II promoter, mitotic
+synonym: "mitotic activation of transcription from Pol II promoter" EXACT []
+synonym: "positive regulation of transcription from Pol II promoter, mitotic" EXACT []
+synonym: "up regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
+synonym: "up-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
+synonym: "upregulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
+synonym: "activation of transcription from RNA polymerase II promoter, mitotic" NARROW []
+synonym: "stimulation of transcription from RNA polymerase II promoter, mitotic" NARROW []
+xref: GO:0046022
+
+[Term]
+id: CCO:P0000220
+name: regulation of transcription from RNA polymerase III promoter, mitotic
+def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000206 ! regulation of transcription, mitotic
+synonym: "mitotic regulation of transcription from Pol III promoter" EXACT []
+synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT []
+xref: GO:0046023
+
+[Term]
+id: CCO:P0000221
+name: positive regulation of transcription from RNA polymerase III promoter, mitotic
+def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
+is_a: CCO:P0000207 ! positive regulation of transcription, mitotic
+is_a: CCO:P0000220 ! regulation of transcription from RNA polymerase III promoter, mitotic
+synonym: "mitotic activation of transcription from Pol III promoter" EXACT []
+synonym: "positive regulation of transcription from Pol III promoter, mitotic" EXACT []
+synonym: "up regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
+synonym: "up-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
+synonym: "upregulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
+synonym: "activation of transcription from RNA polymerase III promoter, mitotic" NARROW []
+synonym: "stimulation of transcription from RNA polymerase III promoter, mitotic" NARROW []
+xref: GO:0046024
+
+[Term]
+id: CCO:P0000222
+name: regulation of centriole replication
+def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]
+is_a: CCO:P0000228 ! regulation of centrosome cycle
+relationship: part_of CCO:P0000097 ! centriole replication
+xref: GO:0046599
+
+[Term]
+id: CCO:P0000223
+name: negative regulation of centriole replication
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole replication." [GOC:ai]
+is_a: CCO:P0000222 ! regulation of centriole replication
+is_a: CCO:P0000229 ! negative regulation of centrosome cycle
+synonym: "down regulation of centriole replication" EXACT []
+synonym: "down-regulation of centriole replication" EXACT []
+synonym: "downregulation of centriole replication" EXACT []
+synonym: "inhibition of centriole replication" NARROW []
+xref: GO:0046600
+
+[Term]
+id: CCO:P0000224
+name: positive regulation of centriole replication
+def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai]
+is_a: CCO:P0000222 ! regulation of centriole replication
+is_a: CCO:P0000230 ! positive regulation of centrosome cycle
+synonym: "up regulation of centriole replication" EXACT []
+synonym: "up-regulation of centriole replication" EXACT []
+synonym: "upregulation of centriole replication" EXACT []
+synonym: "activation of centriole replication" NARROW []
+synonym: "stimulation of centriole replication" NARROW []
+xref: GO:0046601
+
+[Term]
+id: CCO:P0000225
+name: regulation of mitotic centrosome separation
+def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai]
+is_a: CCO:P0000228 ! regulation of centrosome cycle
+relationship: part_of CCO:P0000098 ! mitotic centrosome separation
+xref: GO:0046602
+
+[Term]
+id: CCO:P0000226
+name: negative regulation of mitotic centrosome separation
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of centrosome separation." [GOC:ai]
+is_a: CCO:P0000225 ! regulation of mitotic centrosome separation
+is_a: CCO:P0000229 ! negative regulation of centrosome cycle
+synonym: "down regulation of mitotic centrosome separation" EXACT []
+synonym: "down-regulation of mitotic centrosome separation" EXACT []
+synonym: "downregulation of mitotic centrosome separation" EXACT []
+synonym: "inhibition of mitotic centrosome separation" NARROW []
+xref: GO:0046603
+
+[Term]
+id: CCO:P0000227
+name: positive regulation of mitotic centrosome separation
+def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai]
+is_a: CCO:P0000225 ! regulation of mitotic centrosome separation
+is_a: CCO:P0000230 ! positive regulation of centrosome cycle
+synonym: "up regulation of mitotic centrosome separation" EXACT []
+synonym: "up-regulation of mitotic centrosome separation" EXACT []
+synonym: "upregulation of mitotic centrosome separation" EXACT []
+synonym: "activation of mitotic centrosome separation" NARROW []
+synonym: "stimulation of mitotic centrosome separation" NARROW []
+xref: GO:0046604
+
+[Term]
+id: CCO:P0000228
+name: regulation of centrosome cycle
+def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai]
+relationship: part_of CCO:P0000096 ! centrosome cycle
+xref: GO:0046605
+
+[Term]
+id: CCO:P0000229
+name: negative regulation of centrosome cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai]
+is_a: CCO:P0000228 ! regulation of centrosome cycle
+synonym: "down regulation of centrosome cycle" EXACT []
+synonym: "down-regulation of centrosome cycle" EXACT []
+synonym: "downregulation of centrosome cycle" EXACT []
+synonym: "inhibition of centrosome cycle" NARROW []
+xref: GO:0046606
+
+[Term]
+id: CCO:P0000230
+name: positive regulation of centrosome cycle
+def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai]
+is_a: CCO:P0000228 ! regulation of centrosome cycle
+synonym: "up regulation of centrosome cycle" EXACT []
+synonym: "up-regulation of centrosome cycle" EXACT []
+synonym: "upregulation of centrosome cycle" EXACT []
+synonym: "activation of centrosome cycle" NARROW []
+synonym: "stimulation of centrosome cycle" NARROW []
+xref: GO:0046607
+
+[Term]
+id: CCO:P0000231
+name: suppression by virus of host cell cycle arrest
+def: "Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur." [PMID:9371605]
+is_a: CCO:P0000137 ! modification by virus of host cell cycle regulation
+synonym: "negative regulation by virus of cell cycle arrest" EXACT []
+synonym: "viral inhibition of cell cycle arrest" EXACT []
+xref: GO:0046792
+
+[Term]
+id: CCO:P0000232
+name: replication fork protection
+def: "Processes preventing the collapse of stalled replication forks." [GOC:vw, PMID:14560029]
+relationship: part_of CCO:P0000160 ! intra-S DNA damage checkpoint
+synonym: "replication fork maintenance" BROAD []
+synonym: "replication fork stabilization" BROAD []
+xref: GO:0048478
+
+[Term]
+id: CCO:P0000233
+name: chiasma formation
+def: "The cell cycle process whereby a connection between chromatids forms, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [http:www.onelook.com]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000106 ! synapsis
+xref: GO:0051026
+
+[Term]
+id: CCO:P0000234
+name: regulation of transcription, meiotic
+def: "Any process that modulates the frequency, rate or extent of transcription during meiosis." [GOC:go_curators]
+relationship: part_of CCO:P0000103 ! meiosis
+synonym: "meiotic regulation of transcription" EXACT []
+xref: GO:0051037
+
+[Term]
+id: CCO:P0000235
+name: negative regulation of transcription, meiotic
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during meiosis." [GOC:ai]
+is_a: CCO:P0000234 ! regulation of transcription, meiotic
+synonym: "down regulation of transcription, meiotic" EXACT []
+synonym: "down-regulation of transcription, meiotic" EXACT []
+synonym: "downregulation of transcription, meiotic" EXACT []
+synonym: "meiotic repression of transcription" EXACT []
+synonym: "negative regulation of meiotic transcription" EXACT []
+synonym: "inhibition of transcription, meiotic" NARROW []
+xref: GO:0051038
+
+[Term]
+id: CCO:P0000236
+name: positive regulation of transcription, meiotic
+def: "Any process that activates or increases the frequency, rate or extent of transcription during meiosis." [GOC:ai]
+is_a: CCO:P0000234 ! regulation of transcription, meiotic
+synonym: "positive regulation of meiotic transcription" EXACT []
+synonym: "up regulation of transcription, meiotic" EXACT []
+synonym: "up-regulation of transcription, meiotic" EXACT []
+synonym: "upregulation of transcription, meiotic" EXACT []
+synonym: "activation of transcription, meiotic" NARROW []
+synonym: "stimulation of transcription, meiotic" NARROW []
+xref: GO:0051039
+
+[Term]
+id: CCO:P0000237
+name: meiotic nuclear envelope disassembly
+def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000265 ! meiotic cell cycle
+synonym: "meiotic nuclear envelope breakdown" EXACT []
+synonym: "meiotic nuclear envelope catabolism" EXACT []
+synonym: "meiotic nuclear envelope degradation" EXACT []
+xref: GO:0051078
+
+[Term]
+id: CCO:P0000238
+name: meiosis I nuclear envelope disassembly
+def: "The controlled breakdown of the nuclear envelope during the first division of meiosis." [GOC:bf]
+is_a: CCO:P0000237 ! meiotic nuclear envelope disassembly
+relationship: part_of CCO:P0000104 ! meiosis I
+synonym: "meiosis I nuclear envelope breakdown" EXACT []
+synonym: "meiosis I nuclear envelope catabolism" EXACT []
+synonym: "meiosis I nuclear envelope degradation" EXACT []
+xref: GO:0051079
+
+[Term]
+id: CCO:P0000239
+name: meiosis II nuclear envelope disassembly
+def: "The controlled breakdown of the nuclear envelope during the second division of meiosis." [GOC:bf]
+is_a: CCO:P0000237 ! meiotic nuclear envelope disassembly
+relationship: part_of CCO:P0000112 ! meiosis II
+synonym: "meiosis II nuclear envelope breakdown" EXACT []
+synonym: "meiosis II nuclear envelope catabolism" EXACT []
+synonym: "meiosis II nuclear envelope degradation" EXACT []
+xref: GO:0051080
+
+[Term]
+id: CCO:P0000240
+name: meiotic sister chromatid cohesion
+def: "The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000104 ! meiosis I
+relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
+xref: GO:0051177
+
+[Term]
+id: CCO:P0000241
+name: meiotic chromosome decondensation
+def: "The cell cycle process whereby chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
+xref: GO:0051178
+
+[Term]
+id: CCO:P0000242
+name: meiotic spindle assembly
+def: "The formation of the spindle during a meiotic cell cycle." [GOC:ai]
+is_a: CCO:P0000029 ! meiotic spindle organization and biogenesis
+synonym: "meiotic spindle biogenesis" EXACT []
+synonym: "meiotic spindle biosynthesis" EXACT []
+synonym: "meiotic spindle formation" EXACT []
+synonym: "spindle assembly during meiosis" EXACT []
+synonym: "spindle biogenesis during meiosis" EXACT []
+synonym: "spindle formation during meiosis" EXACT []
+synonym: "bipolar spindle biosynthesis" BROAD []
+synonym: "bipolar spindle formation" BROAD []
+xref: GO:0051226
+
+[Term]
+id: CCO:P0000243
+name: mitotic spindle assembly
+def: "The formation of the spindle during a mitotic cell cycle." [GOC:ai]
+is_a: CCO:P0000058 ! mitotic spindle organization and biogenesis
+synonym: "mitotic spindle biogenesis" EXACT []
+synonym: "mitotic spindle biosynthesis" EXACT []
+synonym: "mitotic spindle formation" EXACT []
+synonym: "spindle assembly during mitosis" EXACT []
+synonym: "spindle biogenesis during mitosis" EXACT []
+synonym: "spindle formation during mitosis" EXACT []
+xref: GO:0051227
+
+[Term]
+id: CCO:P0000244
+name: mitotic spindle disassembly
+def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai]
+is_a: CCO:P0000058 ! mitotic spindle organization and biogenesis
+synonym: "mitotic spindle breakdown" EXACT []
+synonym: "mitotic spindle catabolism" EXACT []
+synonym: "mitotic spindle degradation" EXACT []
+synonym: "spindle breakdown during mitosis" EXACT []
+synonym: "spindle degradation during mitosis" EXACT []
+synonym: "spindle disassembly during mitosis" EXACT []
+xref: GO:0051228
+
+[Term]
+id: CCO:P0000245
+name: meiotic spindle disassembly
+def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai]
+is_a: CCO:P0000029 ! meiotic spindle organization and biogenesis
+synonym: "meiotic spindle breakdown" EXACT []
+synonym: "meiotic spindle catabolism" EXACT []
+synonym: "meiotic spindle degradation" EXACT []
+synonym: "spindle breakdown during meiosis" EXACT []
+synonym: "spindle degradation during meiosis" EXACT []
+synonym: "spindle disassembly during meiosis" EXACT []
+xref: GO:0051229
+
+[Term]
+id: CCO:P0000246
+name: meiotic spindle elongation
+def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai]
+is_a: CCO:P0000310 ! spindle elongation
+relationship: part_of CCO:P0000029 ! meiotic spindle organization and biogenesis
+synonym: "spindle elongation during meiosis" EXACT []
+xref: GO:0051232
+
+[Term]
+id: CCO:P0000247
+name: mitotic spindle midzone assembly
+def: "The formation of the mitotic spindle midzone, the area in the center of the mitotic spindle where the spindle microtubules from opposite poles overlap." [GOC:ai]
+is_a: CCO:P0000311 ! spindle midzone assembly
+relationship: part_of CCO:P0000243 ! mitotic spindle assembly
+synonym: "mitotic spindle midzone biogenesis" EXACT []
+synonym: "mitotic spindle midzone biosynthesis" EXACT []
+synonym: "mitotic spindle midzone formation" EXACT []
+synonym: "spindle midzone assembly during mitosis" EXACT []
+synonym: "spindle midzone biogenesis during mitosis" EXACT []
+synonym: "spindle midzone formation during mitosis" EXACT []
+xref: GO:0051256
+
+[Term]
+id: CCO:P0000248
+name: meiotic spindle midzone assembly
+def: "The formation of the meiotic spindle midzone, the area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:ai]
+is_a: CCO:P0000311 ! spindle midzone assembly
+relationship: part_of CCO:P0000242 ! meiotic spindle assembly
+synonym: "meiotic spindle midzone biogenesis" EXACT []
+synonym: "meiotic spindle midzone biosynthesis" EXACT []
+synonym: "meiotic spindle midzone formation" EXACT []
+synonym: "spindle midzone assembly during meiosis" EXACT []
+synonym: "spindle midzone biogenesis during meiosis" EXACT []
+synonym: "spindle midzone formation during meiosis" EXACT []
+xref: GO:0051257
+
+[Term]
+id: CCO:P0000249
+name: establishment of meiotic spindle localization
+def: "The cell cycle process whereby the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000265 ! meiotic cell cycle
+synonym: "meiotic spindle positioning" EXACT []
+synonym: "spindle positioning during meiosis" EXACT []
+xref: GO:0051295
+
+[Term]
+id: CCO:P0000250
+name: establishment of meiotic spindle orientation
+def: "The processes that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai]
+is_a: CCO:P0000249 ! establishment of meiotic spindle localization
+synonym: "establishment of spindle orientation during meiosis" EXACT []
+synonym: "meiotic spindle orientation" EXACT []
+synonym: "orienting of meiotic spindle" EXACT []
+xref: GO:0051296
+
+[Term]
+id: CCO:P0000251
+name: centrosome duplication
+def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
+relationship: part_of CCO:P0000096 ! centrosome cycle
+synonym: "centrosome replication" EXACT []
+xref: GO:0051298
+
+[Term]
+id: CCO:P0000252
+name: centrosome separation
+def: "The process by which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
+relationship: part_of CCO:P0000096 ! centrosome cycle
+xref: GO:0051299
+
+[Term]
+id: CCO:P0000253
+name: mitotic sister chromatid separation
+def: "The process by which sister chromatids are physically detached from each other during mitosis." [GOC:ai]
+is_a: CCO:P0000312 ! chromosome separation
+relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
+synonym: "chromosome separation during mitosis" RELATED []
+synonym: "mitotic chromosome separation" RELATED []
+synonym: "sister chromatid separation during mitosis" EXACT []
+xref: GO:0051306
+
+[Term]
+id: CCO:P0000254
+name: meiotic chromosome separation
+def: "The process by which chromosomes are physically detached from each other during meiosis." [GOC:ai]
+is_a: CCO:P0000312 ! chromosome separation
+relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
+synonym: "chromosome separation during meiosis" EXACT []
+xref: GO:0051307
+
+[Term]
+id: CCO:P0000255
+name: male meiosis chromosome separation
+def: "The process by which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai]
+is_a: CCO:P0000065 ! male meiosis chromosome segregation
+is_a: CCO:P0000254 ! meiotic chromosome separation
+synonym: "chromosome separation during male meiosis" EXACT []
+xref: GO:0051308
+
+[Term]
+id: CCO:P0000256
+name: female meiosis chromosome separation
+def: "The process by which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai]
+is_a: CCO:P0000132 ! female meiosis chromosome segregation
+is_a: CCO:P0000254 ! meiotic chromosome separation
+synonym: "chromosome separation during female meiosis" EXACT []
+xref: GO:0051309
+
+[Term]
+id: CCO:P0000257
+name: meiotic metaphase plate congression
+def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
+synonym: "metaphase plate congression during meiosis" EXACT []
+xref: GO:0051311
+
+[Term]
+id: CCO:P0000258
+name: attachment of spindle microtubules to mitotic chromosome
+def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during mitosis." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
+xref: GO:0051314
+
+[Term]
+id: CCO:P0000259
+name: attachment of spindle microtubules to kinetochore during mitosis
+def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000002 ! mitotic sister chromatid segregation
+xref: GO:0051315
+
+[Term]
+id: CCO:P0000260
+name: attachment of spindle microtubules to kinetochore during meiotic chromosome segregation
+def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiotic chromosome segregation." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
+synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED []
+xref: GO:0051316
+
+[Term]
+id: CCO:P0000261
+name: attachment of spindle microtubules to meiotic chromosome
+def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during meiosis." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000189 ! meiotic chromosome segregation
+xref: GO:0051317
+
+[Term]
+id: CCO:P0000262
+name: G1 phase
+def: "Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:ai]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000269 ! interphase
+xref: GO:0051318
+
+[Term]
+id: CCO:P0000263
+name: G2 phase
+def: "Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:ai]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000269 ! interphase
+xref: GO:0051319
+
+[Term]
+id: CCO:P0000264
+name: S phase
+def: "Progression through S phase, the part of the cell cycle during which DNA synthesis takes place." [GOC:ai]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000269 ! interphase
+xref: GO:0051320
+
+[Term]
+id: CCO:P0000265
+name: meiotic cell cycle
+def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai]
+is_a: CCO:P0000056 ! cell cycle
+xref: GO:0051321
+
+[Term]
+id: CCO:P0000266
+name: anaphase
+def: "Progression through anaphase, the third stage of chromosome segregation in the cell cycle. Canonically, sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle." [http:www.onelook.com]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000038 ! M phase
+xref: GO:0051322
+
+[Term]
+id: CCO:P0000267
+name: metaphase
+def: "Progression through metaphase, the second stage of chromosome segregation in the cell cycle. Canonically, chromosomes become aligned on the equatorial plate of the cell." [http:www.onelook.com]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000038 ! M phase
+xref: GO:0051323
+
+[Term]
+id: CCO:P0000268
+name: prophase
+def: "Progression through prophase, the first stage of chromosome segregation in the cell cycle. Canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:ai]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000038 ! M phase
+xref: GO:0051324
+
+[Term]
+id: CCO:P0000269
+name: interphase
+def: "Progression through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [http:www.onelook.com]
+is_a: CCO:P0000309 ! cell cycle phase
+synonym: "karyostasis" EXACT []
+synonym: "resting phase" BROAD []
+xref: GO:0051325
+
+[Term]
+id: CCO:P0000270
+name: telophase
+def: "Progression through telophase, the last stage of chromosome segregation in the cell cycle. Canonically, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [http:www.onelook.com]
+is_a: CCO:P0000309 ! cell cycle phase
+relationship: part_of CCO:P0000038 ! M phase
+xref: GO:0051326
+
+[Term]
+id: CCO:P0000271
+name: M phase of meiotic cell cycle
+def: "Progression through M phase, the part of the meiotic cell cycle during which meiosis and cytokinesis take place." [GOC:ai]
+is_a: CCO:P0000038 ! M phase
+relationship: part_of CCO:P0000265 ! meiotic cell cycle
+xref: GO:0051327
+
+[Term]
+id: CCO:P0000272
+name: interphase of meiotic cell cycle
+def: "Progression through interphase, the stage of cell cycle between successive rounds of meiosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai]
+is_a: CCO:P0000269 ! interphase
+relationship: part_of CCO:P0000265 ! meiotic cell cycle
+xref: GO:0051328
+
+[Term]
+id: CCO:P0000273
+name: interphase of mitotic cell cycle
+def: "Progression through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai]
+is_a: CCO:P0000269 ! interphase
+relationship: part_of CCO:P0000037 ! mitotic cell cycle
+xref: GO:0051329
+
+[Term]
+id: CCO:P0000274
+name: G1 phase of meiotic cell cycle
+def: "Progression through G1 phase, one of two 'gap' phases in the meiotic cell cycle; G1 is the interval between the completion of meiosis and the beginning of DNA synthesis." [GOC:ai]
+is_a: CCO:P0000262 ! G1 phase
+relationship: part_of CCO:P0000272 ! interphase of meiotic cell cycle
+xref: GO:0051330
+
+[Term]
+id: CCO:P0000275
+name: G2 phase of meiotic cell cycle
+def: "Progression through G2 phase, one of two 'gap' phases in the meiotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of meiosis." [GOC:ai]
+is_a: CCO:P0000263 ! G2 phase
+relationship: part_of CCO:P0000272 ! interphase of meiotic cell cycle
+xref: GO:0051331
+
+[Term]
+id: CCO:P0000276
+name: S phase of meiotic cell cycle
+def: "Progression through S phase, the part of the meiotic cell cycle during which DNA synthesis takes place." [GOC:ai]
+is_a: CCO:P0000264 ! S phase
+relationship: part_of CCO:P0000272 ! interphase of meiotic cell cycle
+xref: GO:0051332
+
+[Term]
+id: CCO:P0000277
+name: meiotic nuclear envelope reassembly
+def: "The cell cycle process whereby the reformation of the nuclear envelope during meiosis occurs." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000265 ! meiotic cell cycle
+xref: GO:0051333
+
+[Term]
+id: CCO:P0000278
+name: meiosis I nuclear envelope reassembly
+def: "The reformation of the nuclear envelope during meiosis I." [GOC:ai]
+is_a: CCO:P0000277 ! meiotic nuclear envelope reassembly
+relationship: part_of CCO:P0000104 ! meiosis I
+xref: GO:0051334
+
+[Term]
+id: CCO:P0000279
+name: meiosis II nuclear envelope reassembly
+def: "The reformation of the nuclear envelope during meiosis II." [GOC:ai]
+is_a: CCO:P0000277 ! meiotic nuclear envelope reassembly
+relationship: part_of CCO:P0000112 ! meiosis II
+xref: GO:0051335
+
+[Term]
+id: CCO:P0000280
+name: interphase microtubule nucleation by interphase microtubule organizing center
+def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai]
+relationship: part_of CCO:P0000269 ! interphase
+synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT []
+synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT []
+synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT []
+synonym: "microtubule nucleation during interphase by IMTOC" EXACT []
+synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT []
+xref: GO:0051415
+
+[Term]
+id: CCO:P0000281
+name: negative regulation of ubiquitin ligase activity during mitotic cell cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai]
+is_a: CCO:P0000283 ! regulation of ubiquitin ligase activity during mitotic cell cycle
+synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
+synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
+synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
+synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW []
+synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW []
+synonym: "APC inhibition during mitotic cell cycle" NARROW []
+synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW []
+synonym: "mitotic anaphase promoting complex inhibition" NARROW []
+synonym: "mitotic anaphase promoting complex inhibitor" NARROW []
+synonym: "mitotic anaphase-promoting complex inhibition" NARROW []
+synonym: "mitotic anaphase-promoting complex inhibitor" NARROW []
+synonym: "mitotic APC inhibition" NARROW []
+synonym: "mitotic APC inhibitor" NARROW []
+synonym: "mitotic SCF complex inhibitor" NARROW []
+synonym: "mitotic ubiquitin ligase inhibitor" NARROW []
+xref: GO:0051436
+
+[Term]
+id: CCO:P0000282
+name: positive regulation of ubiquitin ligase activity during mitotic cell cycle
+def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai]
+is_a: CCO:P0000283 ! regulation of ubiquitin ligase activity during mitotic cell cycle
+synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
+synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
+synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
+synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
+synonym: "mitotic SCF complex activator" NARROW []
+synonym: "mitotic ubiquitin ligase activator" NARROW []
+synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
+xref: GO:0051437
+
+[Term]
+id: CCO:P0000283
+name: regulation of ubiquitin ligase activity during mitotic cell cycle
+def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000037 ! mitotic cell cycle
+synonym: "mitotic ubiquitin ligase regulator" RELATED []
+synonym: "mitotic ubiquitin-protein ligase regulator" RELATED []
+synonym: "regulation of ubiquitin-protein ligase activity during mitotic cell cycle" EXACT []
+synonym: "mitotic anaphase-promoting complex regulator" NARROW []
+synonym: "mitotic APC regulator" NARROW []
+synonym: "mitotic SCF complex regulator" NARROW []
+xref: GO:0051439
+
+[Term]
+id: CCO:P0000284
+name: regulation of ubiquitin ligase activity during meiotic cell cycle
+def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [EC:6.3.2.19, GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000265 ! meiotic cell cycle
+synonym: "meiotic ubiquitin ligase regulator" RELATED []
+synonym: "meiotic ubiquitin-protein ligase regulator" RELATED []
+synonym: "regulation of ubiquitin-protein ligase activity during meiotic cell cycle" EXACT []
+synonym: "meiotic anaphase-promoting complex regulator" NARROW []
+synonym: "meiotic APC regulator" NARROW []
+synonym: "meiotic SCF complex regulator" NARROW []
+xref: GO:0051440
+
+[Term]
+id: CCO:P0000285
+name: positive regulation of ubiquitin ligase activity during meiotic cell cycle
+def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai]
+is_a: CCO:P0000284 ! regulation of ubiquitin ligase activity during meiotic cell cycle
+synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
+synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
+synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
+synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
+synonym: "meiotic SCF complex activator" NARROW []
+synonym: "meiotic ubiquitin ligase activator" NARROW []
+synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
+xref: GO:0051441
+
+[Term]
+id: CCO:P0000286
+name: negative regulation of ubiquitin ligase activity during meiotic cell cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai]
+is_a: CCO:P0000284 ! regulation of ubiquitin ligase activity during meiotic cell cycle
+synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
+synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
+synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
+synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW []
+synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW []
+synonym: "APC inhibition during meiotic cell cycle" NARROW []
+synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW []
+synonym: "meiotic anaphase promoting complex inhibition" NARROW []
+synonym: "meiotic anaphase promoting complex inhibitor" NARROW []
+synonym: "meiotic anaphase-promoting complex inhibition" NARROW []
+synonym: "meiotic anaphase-promoting complex inhibitor" NARROW []
+synonym: "meiotic APC inhibition" NARROW []
+synonym: "meiotic APC inhibitor" NARROW []
+synonym: "meiotic SCF complex inhibitor" NARROW []
+synonym: "meiotic ubiquitin ligase inhibitor" NARROW []
+xref: GO:0051442
+
+[Term]
+id: CCO:P0000287
+name: regulation of progression through meiotic cell cycle
+def: "Any process that modulates the rate or extent of progression through the mitotic cell cycle." [GOC:ai]
+is_a: CCO:P0000004 ! regulation of progression through cell cycle
+relationship: part_of CCO:P0000265 ! meiotic cell cycle
+synonym: "meiotic cell cycle regulator" RELATED []
+synonym: "control of meiotic cell cycle progression" EXACT []
+synonym: "meiotic cell cycle control" EXACT []
+synonym: "meiotic cell cycle modulation" EXACT []
+synonym: "meiotic cell cycle regulation" EXACT []
+synonym: "modulation of meiotic cell cycle progression" EXACT []
+synonym: "regulation of meiotic cell cycle" EXACT []
+synonym: "regulation of meiotic cell cycle progression" EXACT []
+xref: GO:0051445
+
+[Term]
+id: CCO:P0000288
+name: positive regulation of progression through meiotic cell cycle
+def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai]
+is_a: CCO:P0000199 ! positive regulation of progression through cell cycle
+is_a: CCO:P0000287 ! regulation of progression through meiotic cell cycle
+synonym: "positive regulation of meiotic cell cycle progression" EXACT []
+synonym: "up regulation of progression through meiotic cell cycle" EXACT []
+synonym: "up-regulation of progression through meiotic cell cycle" EXACT []
+synonym: "upregulation of progression through meiotic cell cycle" EXACT []
+synonym: "activation of progression through meiotic cell cycle" NARROW []
+synonym: "stimulation of progression through meiotic cell cycle" NARROW []
+xref: GO:0051446
+
+[Term]
+id: CCO:P0000289
+name: negative regulation of progression through meiotic cell cycle
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai]
+is_a: CCO:P0000198 ! negative regulation of progression through cell cycle
+is_a: CCO:P0000287 ! regulation of progression through meiotic cell cycle
+synonym: "down regulation of progression through meiotic cell cycle" EXACT []
+synonym: "down-regulation of progression through meiotic cell cycle" EXACT []
+synonym: "downregulation of progression through meiotic cell cycle" EXACT []
+synonym: "negative regulation of meiotic cell cycle progression" EXACT []
+synonym: "inhibition of progression through meiotic cell cycle" NARROW []
+xref: GO:0051447
+
+[Term]
+id: CCO:P0000290
+name: attachment of spindle microtubules to kinetochore during meiosis I
+def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt]
+is_a: CCO:P0000260 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation
+relationship: part_of CCO:P0000191 ! homologous chromosome segregation
+synonym: "monopolar attachment" EXACT []
+synonym: "sister kinetochore monoorientation" EXACT []
+comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis.
+xref: GO:0051455
+
+[Term]
+id: CCO:P0000291
+name: attachment of spindle microtubules to kinetochore during meiosis II
+def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt]
+is_a: CCO:P0000260 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation
+relationship: part_of CCO:P0000192 ! meiotic sister chromatid segregation
+xref: GO:0051456
+
+[Term]
+id: CCO:P0000292
+name: anaphase-promoting complex activation during meiotic cell cycle
+def: "Any process that initiatiates the ubiquitin ligase activity of the anaphase-promoting complex during the meiotic cell cycle." [GOC:mah, PMID:10871297]
+is_a: CCO:P0000285 ! positive regulation of ubiquitin ligase activity during meiotic cell cycle
+synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" EXACT []
+synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" EXACT []
+synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" EXACT []
+synonym: "anaphase promoting complex activation during meiotic cell cycle" EXACT []
+synonym: "APC activation during meiotic cell cycle" EXACT []
+synonym: "meiotic anaphase promoting complex activation" EXACT []
+synonym: "meiotic APC activation" EXACT []
+synonym: "meiotic anaphase promoting complex activator" NARROW []
+synonym: "meiotic anaphase-promoting complex activator" NARROW []
+synonym: "meiotic APC activator" NARROW []
+xref: GO:0051487
+
+[Term]
+id: CCO:P0000293
+name: meiotic recombination checkpoint
+def: "A checkpoint during late prophase I (pachytene) which prevents segregation of homologous chromosomes until recombination is completed and ensures proper distribution of the genetic material to the gametes." [PMID:14718568]
+is_a: CCO:P0000005 ! cell cycle checkpoint
+is_a: CCO:P0000200 ! negative regulation of meiosis
+relationship: part_of CCO:P0000105 ! meiotic prophase I
+synonym: "pachytene checkpoint" EXACT []
+xref: GO:0051598
+
+[Term]
+id: CCO:P0000294
+name: regulation of cell cycle
+def: "A cell cycle process that modulates the rate, extent or mode of the cell cycle." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+synonym: "cell cycle control" EXACT []
+synonym: "cell cycle modulation" EXACT []
+synonym: "cell cycle regulation" EXACT []
+xref: GO:0051726
+
+[Term]
+id: CCO:P0000295
+name: cell cycle switching, meiotic to mitotic cell cycle
+def: "The process by which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai]
+is_a: CCO:P0000294 ! regulation of cell cycle
+synonym: "conversion to mitotic cell cycle" EXACT []
+synonym: "entry into mitotic cell cycle" EXACT []
+synonym: "initiation of mitotic cell cycle" EXACT []
+synonym: "cell cycle switching, meiotis to mitosis" NARROW []
+synonym: "conversion to mitosis" NARROW []
+synonym: "entry into mitosis" NARROW []
+synonym: "initiation of mitosis" NARROW []
+synonym: "mitotic entry" NARROW []
+xref: GO:0051727
+
+[Term]
+id: CCO:P0000296
+name: cell cycle switching, mitotic to meiotic cell cycle
+def: "The process by which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai]
+is_a: CCO:P0000294 ! regulation of cell cycle
+synonym: "conversion to meiotic cell cycle" EXACT []
+synonym: "entry into meiotic cell cycle" EXACT []
+synonym: "initiation of meiotic cell cycle" EXACT []
+synonym: "cell cycle switching, mitotis to meiosis" NARROW []
+synonym: "conversion to meiosis" NARROW []
+synonym: "entry into meiosis" NARROW []
+synonym: "initiation of meiosis" NARROW []
+synonym: "meiotic entry" NARROW []
+xref: GO:0051728
+xref: GO:0042061
+
+[Term]
+id: CCO:P0000297
+name: germline cell cycle switching, mitotic to meiotic cell cycle
+def: "The process by which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai]
+is_a: CCO:P0000296 ! cell cycle switching, mitotic to meiotic cell cycle
+synonym: "germline conversion to meiotic cell cycle" EXACT []
+synonym: "germline entry into meiotic cell cycle" EXACT []
+synonym: "germline initiation of meiotic cell cycle" EXACT []
+synonym: "germline cell cycle switching, mitotis to meiosis" NARROW []
+synonym: "germline conversion to meiosis" NARROW []
+synonym: "germline entry into meiosis" NARROW []
+synonym: "germline initiation of meiosis" NARROW []
+synonym: "germline meiotic entry" NARROW []
+xref: GO:0051729
+
+[Term]
+id: CCO:P0000298
+name: meiotic sister chromatid cohesion, centromeric
+def: "The cell cycle process whereby centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000240 ! meiotic sister chromatid cohesion
+synonym: "meiotic sister chromatid cohesion at centromere" EXACT []
+synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT []
+xref: GO:0051754
+
+[Term]
+id: CCO:P0000299
+name: meiotic sister chromatid arm separation
+def: "The cell cycle process whereby sister chromatid arms are physically detached from each other during meiosis." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000104 ! meiosis I
+relationship: part_of CCO:P0000301 ! meiotic sister chromatid separation
+xref: GO:0051755
+
+[Term]
+id: CCO:P0000300
+name: meiotic sister chromatid centromere separation
+def: "The cell cycle process whereby the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000192 ! meiotic sister chromatid segregation
+relationship: part_of CCO:P0000301 ! meiotic sister chromatid separation
+xref: GO:0051756
+
+[Term]
+id: CCO:P0000301
+name: meiotic sister chromatid separation
+def: "The process by which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
+is_a: CCO:P0000254 ! meiotic chromosome separation
+xref: GO:0051757
+
+[Term]
+id: CCO:P0000302
+name: homologous chromosome movement towards spindle pole during meiosis I
+def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I." [GOC:ai]
+is_a: CCO:P0000134 ! meiotic chromosome movement towards spindle pole
+relationship: part_of CCO:P0000191 ! homologous chromosome segregation
+synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT []
+xref: GO:0051758
+
+[Term]
+id: CCO:P0000303
+name: sister chromosome movement towards spindle pole during meiosis II
+def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai]
+is_a: CCO:P0000134 ! meiotic chromosome movement towards spindle pole
+relationship: part_of CCO:P0000192 ! meiotic sister chromatid segregation
+synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT []
+xref: GO:0051759
+
+[Term]
+id: CCO:P0000304
+name: meiotic sister chromatid cohesion, arms
+def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000240 ! meiotic sister chromatid cohesion
+synonym: "meiotic sister chromatid cohesion along arms" EXACT []
+synonym: "sister chromatid cohesion along arms at meiosis I" EXACT []
+xref: GO:0051760
+
+[Term]
+id: CCO:P0000305
+name: lateral element assembly
+def: "The cell cycle process whereby lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847]
+is_a: CCO:P0000308 ! cell cycle process
+relationship: part_of CCO:P0000107 ! synaptonemal complex assembly
+xref: GO:0051878
+
+[Term]
+id: CCO:P0000306
+name: maintenance of contractile ring localization
+def: "The processes by which a contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah]
+relationship: part_of CCO:P0000153 ! cytokinesis, contractile ring maintenance
+synonym: "cytokinetic ring anchoring" RELATED []
+xref: GO:0032189
+
+[Term]
+id: CCO:P0000307
+name: cell cycle arrest of committed forebrain neuronal progenitor cell
+def: "The process by which progression through the cell cycle is halted in a cell that has been committed to become a neuron that will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
+is_a: CCO:P0000057 ! cell cycle arrest
+comment: This term was added by GO_REF:0000021.
+xref: GO:0021883
+
+[Term]
+id: CCO:P0000308
+name: cell cycle process
+def: "A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:isa_complete]
+relationship: part_of CCO:P0000056 ! cell cycle
+xref: GO:0022402
+
+[Term]
+id: CCO:P0000309
+name: cell cycle phase
+def: "A cell cycle process composed of one of the morphological steps through which a cell progresses during successive cell replication or nuclear replication events." [GOC:isa_complete]
+is_a: CCO:P0000308 ! cell cycle process
+xref: GO:0022403
+
+[Term]
+id: CCO:P0000310
+name: spindle elongation
+def: "The cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+xref: GO:0051231
+
+[Term]
+id: CCO:P0000311
+name: spindle midzone assembly
+def: "The cell cycle process whereby spindle midzone is formed. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
+is_a: CCO:P0000308 ! cell cycle process
+synonym: "spindle midzone biogenesis" EXACT []
+synonym: "spindle midzone biosynthesis" EXACT []
+synonym: "spindle midzone formation" EXACT []
+xref: GO:0051255
+
+[Term]
+id: CCO:P0000312
+name: chromosome separation
+def: "The cell cycle process whereby paired chromosomes are detached from each other. In budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions." [GOC:ai]
+is_a: CCO:P0000308 ! cell cycle process
+xref: GO:0051304
+
+[Term]
+id: CCO:P0000313
+name: distributive segregation
+def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over -- either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) -- but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart]
+is_a: CCO:P0000189 ! meiotic chromosome segregation
+xref: GO:0032837
+
+[Term]
+id: CCO:P0000314
+name: regulation of spindle elongation
+def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:mah]
+relationship: part_of CCO:P0000310 ! spindle elongation
+xref: GO:0032887
+
+[Term]
+id: CCO:P0000315
+name: regulation of mitotic spindle elongation
+def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the mitotic spindle." [GOC:mah]
+is_a: CCO:P0000314 ! regulation of spindle elongation
+relationship: part_of CCO:P0000001 ! mitotic spindle elongation
+xref: GO:0032888
+
+[Term]
+id: CCO:T0000001
+name: Tetrapoda organism
+is_a: CCO:T0000050 ! Sarcopterygii organism
+xref: NCBI:32523
+
+[Term]
+id: CCO:T0000002
+name: Ascomycota organism
+is_a: CCO:T0000025 ! Fungi organism
+xref: NCBI:4890
+
+[Term]
+id: CCO:T0000003
+name: Theria organism
+is_a: CCO:T0000055 ! Mammalia organism
+xref: NCBI:32525
+
+[Term]
+id: CCO:T0000004
+name: Homo sapiens organism
+is_a: CCO:T0000052 ! Homo organism
+xref: NCBI:9606
+
+[Term]
+id: CCO:T0000005
+name: Coelomata organism
+is_a: CCO:T0000035 ! Bilateria organism
+xref: NCBI:33316
+
+[Term]
+id: CCO:T0000006
+name: Euteleostomi organism
+is_a: CCO:T0000026 ! Teleostomi organism
+xref: NCBI:117571
+
+[Term]
+id: CCO:T0000007
+name: rosids organism
+is_a: CCO:T0000037 ! core eudicotyledons organism
+xref: NCBI:71275
+
+[Term]
+id: CCO:T0000008
+name: Schizosaccharomyces organism
+is_a: CCO:T0000054 ! Schizosaccharomycetaceae organism
+xref: NCBI:4895
+
+[Term]
+id: CCO:T0000009
+name: Streptophyta organism
+is_a: CCO:T0000012 ! Viridiplantae organism
+xref: NCBI:35493
+
+[Term]
+id: CCO:T0000010
+name: Magnoliophyta organism
+is_a: CCO:T0000031 ! Spermatophyta organism
+xref: NCBI:3398
+
+[Term]
+id: CCO:T0000011
+name: organism
+is_a: CCO:U0000001 ! cell-cycle continuant
+xref: NCBI:1
+
+[Term]
+id: CCO:T0000012
+name: Viridiplantae organism
+is_a: CCO:T0000032 ! Eukaryota organism
+xref: NCBI:33090
+
+[Term]
+id: CCO:T0000013
+name: Schizosaccharomycetales organism
+is_a: CCO:T0000024 ! Schizosaccharomycetes organism
+xref: NCBI:34346
+
+[Term]
+id: CCO:T0000014
+name: Saccharomycetales organism
+is_a: CCO:T0000039 ! Saccharomycetes organism
+xref: NCBI:4892
+
+[Term]
+id: CCO:T0000015
+name: eudicotyledons organism
+is_a: CCO:T0000010 ! Magnoliophyta organism
+xref: NCBI:71240
+
+[Term]
+id: CCO:T0000016
+name: Saccharomyces cerevisiae organism
+is_a: CCO:T0000019 ! Saccharomyces organism
+xref: NCBI:4932
+
+[Term]
+id: CCO:T0000017
+name: Schizosaccharomyces pombe organism
+is_a: CCO:T0000008 ! Schizosaccharomyces organism
+xref: NCBI:4896
+
+[Term]
+id: CCO:T0000018
+name: Euphyllophyta organism
+is_a: CCO:T0000030 ! Tracheophyta organism
+xref: NCBI:78536
+
+[Term]
+id: CCO:T0000019
+name: Saccharomyces organism
+is_a: CCO:T0000034 ! Saccharomycetaceae organism
+xref: NCBI:4930
+
+[Term]
+id: CCO:T0000020
+name: Metazoa organism
+is_a: CCO:T0000041 ! Fungi/Metazoa group organism
+xref: NCBI:33208
+
+[Term]
+id: CCO:T0000021
+name: Homo/Pan/Gorilla group organism
+is_a: CCO:T0000058 ! Hominidae organism
+xref: NCBI:207598
+
+[Term]
+id: CCO:T0000022
+name: Brassicales organism
+is_a: CCO:T0000060 ! eurosids II organism
+xref: NCBI:3699
+
+[Term]
+id: CCO:T0000023
+name: Embryophyta organism
+is_a: CCO:T0000051 ! Streptophytina organism
+xref: NCBI:3193
+
+[Term]
+id: CCO:T0000024
+name: Schizosaccharomycetes organism
+is_a: CCO:T0000002 ! Ascomycota organism
+xref: NCBI:147554
+
+[Term]
+id: CCO:T0000025
+name: Fungi organism
+is_a: CCO:T0000041 ! Fungi/Metazoa group organism
+xref: NCBI:4751
+
+[Term]
+id: CCO:T0000026
+name: Teleostomi organism
+is_a: CCO:T0000049 ! Gnathostomata organism
+xref: NCBI:117570
+
+[Term]
+id: CCO:T0000027
+name: Brassicaceae organism
+is_a: CCO:T0000022 ! Brassicales organism
+xref: NCBI:3700
+
+[Term]
+id: CCO:T0000028
+name: Primates organism
+is_a: CCO:T0000053 ! Euarchontoglires organism
+xref: NCBI:9443
+
+[Term]
+id: CCO:T0000029
+name: Hominoidea organism
+is_a: CCO:T0000046 ! Catarrhini organism
+xref: NCBI:314295
+
+[Term]
+id: CCO:T0000030
+name: Tracheophyta organism
+is_a: CCO:T0000023 ! Embryophyta organism
+xref: NCBI:58023
+
+[Term]
+id: CCO:T0000031
+name: Spermatophyta organism
+is_a: CCO:T0000018 ! Euphyllophyta organism
+xref: NCBI:58024
+
+[Term]
+id: CCO:T0000032
+name: Eukaryota organism
+is_a: CCO:T0000040 ! cellular organisms organism
+xref: NCBI:2759
+
+[Term]
+id: CCO:T0000033
+name: Arabidopsis thaliana organism
+is_a: CCO:T0000057 ! Arabidopsis organism
+xref: NCBI:3702
+
+[Term]
+id: CCO:T0000034
+name: Saccharomycetaceae organism
+is_a: CCO:T0000014 ! Saccharomycetales organism
+xref: NCBI:4893
+
+[Term]
+id: CCO:T0000035
+name: Bilateria organism
+is_a: CCO:T0000048 ! Eumetazoa organism
+xref: NCBI:33213
+
+[Term]
+id: CCO:T0000036
+name: Vertebrata organism
+is_a: CCO:T0000044 ! Craniata organism
+xref: NCBI:7742
+
+[Term]
+id: CCO:T0000037
+name: core eudicotyledons organism
+is_a: CCO:T0000015 ! eudicotyledons organism
+xref: NCBI:91827
+
+[Term]
+id: CCO:T0000038
+name: Saccharomycotina organism
+is_a: CCO:T0000002 ! Ascomycota organism
+xref: NCBI:147537
+
+[Term]
+id: CCO:T0000039
+name: Saccharomycetes organism
+is_a: CCO:T0000038 ! Saccharomycotina organism
+xref: NCBI:4891
+
+[Term]
+id: CCO:T0000040
+name: cellular organisms organism
+is_a: CCO:T0000011 ! organism
+xref: NCBI:131567
+
+[Term]
+id: CCO:T0000041
+name: Fungi/Metazoa group organism
+is_a: CCO:T0000032 ! Eukaryota organism
+xref: NCBI:33154
+
+[Term]
+id: CCO:T0000042
+name: Amniota organism
+is_a: CCO:T0000001 ! Tetrapoda organism
+xref: NCBI:32524
+
+[Term]
+id: CCO:T0000043
+name: Deuterostomia organism
+is_a: CCO:T0000005 ! Coelomata organism
+xref: NCBI:33511
+
+[Term]
+id: CCO:T0000044
+name: Craniata organism
+is_a: CCO:T0000045 ! Chordata organism
+xref: NCBI:89593
+
+[Term]
+id: CCO:T0000045
+name: Chordata organism
+is_a: CCO:T0000043 ! Deuterostomia organism
+xref: NCBI:7711
+
+[Term]
+id: CCO:T0000046
+name: Catarrhini organism
+is_a: CCO:T0000047 ! Simiiformes organism
+xref: NCBI:9526
+
+[Term]
+id: CCO:T0000047
+name: Simiiformes organism
+is_a: CCO:T0000059 ! Haplorrhini organism
+xref: NCBI:314293
+
+[Term]
+id: CCO:T0000048
+name: Eumetazoa organism
+is_a: CCO:T0000020 ! Metazoa organism
+xref: NCBI:6072
+
+[Term]
+id: CCO:T0000049
+name: Gnathostomata organism
+is_a: CCO:T0000036 ! Vertebrata organism
+xref: NCBI:7776
+
+[Term]
+id: CCO:T0000050
+name: Sarcopterygii organism
+is_a: CCO:T0000006 ! Euteleostomi organism
+xref: NCBI:8287
+
+[Term]
+id: CCO:T0000051
+name: Streptophytina organism
+is_a: CCO:T0000009 ! Streptophyta organism
+xref: NCBI:131221
+
+[Term]
+id: CCO:T0000052
+name: Homo organism
+is_a: CCO:T0000021 ! Homo/Pan/Gorilla group organism
+xref: NCBI:9605
+
+[Term]
+id: CCO:T0000053
+name: Euarchontoglires organism
+is_a: CCO:T0000056 ! Eutheria organism
+xref: NCBI:314146
+
+[Term]
+id: CCO:T0000054
+name: Schizosaccharomycetaceae organism
+is_a: CCO:T0000013 ! Schizosaccharomycetales organism
+xref: NCBI:4894
+
+[Term]
+id: CCO:T0000055
+name: Mammalia organism
+is_a: CCO:T0000042 ! Amniota organism
+xref: NCBI:40674
+
+[Term]
+id: CCO:T0000056
+name: Eutheria organism
+is_a: CCO:T0000003 ! Theria organism
+xref: NCBI:9347
+
+[Term]
+id: CCO:T0000057
+name: Arabidopsis organism
+is_a: CCO:T0000027 ! Brassicaceae organism
+xref: NCBI:3701
+
+[Term]
+id: CCO:T0000058
+name: Hominidae organism
+is_a: CCO:T0000029 ! Hominoidea organism
+xref: NCBI:9604
+
+[Term]
+id: CCO:T0000059
+name: Haplorrhini organism
+is_a: CCO:T0000028 ! Primates organism
+xref: NCBI:376913
+
+[Term]
+id: CCO:T0000060
+name: eurosids II organism
+is_a: CCO:T0000007 ! rosids organism
+xref: NCBI:91836
+
+[Term]
+id: CCO:U0000000
+name: cell-cycle entity
+def: "A process or continuant." [CCO:ea]
+synonym: "cell cycle entity" EXACT [CCO:ea]
+
+[Term]
+id: CCO:U0000001
+name: cell-cycle continuant
+def: "Entities which endure, or continue to exist, through time while undergoing different sort of changes, including changes of place." [PMID:15892874]
+disjoint_from: CCO:U0000002
+is_a: CCO:U0000000 ! cell-cycle entity
+synonym: "cell cycle continuant" EXACT [CCO:ea]
+synonym: "endurant" EXACT [PMID:15892874]
+synonym: "thing" BROAD [PMID:15892874]
+
+[Term]
+id: CCO:U0000002
+name: cell-cycle process
+def: "Entities that unfold themselves in successive temporal phases." [PMID:15892874]
+disjoint_from: CCO:U0000001
+is_a: CCO:U0000000 ! cell-cycle entity
+synonym: "perdurant" EXACT [PMID:15892874]
+synonym: "ocurrent" BROAD [PMID:15892874]
+synonym: "cell cycle process" EXACT [CCO:ea]
+
+[Term]
+id: CCO:U0000003
+name: biopolymer
+def: "A polymer, such as a protein, nucleic acid, or transcript, ocurring in, or formed by, living systems." [CCO:ea]
+is_a: CCO:U0000001 ! cell-cycle continuant
+synonym: "bio-polymer" EXACT [CCO:ea]
+
+[Term]
+id: CCO:U0000004
+name: gene
+def: "A locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions and/or other functional sequence regions." [SO:0000704]
+disjoint_from: CCO:U0000005
+is_a: CCO:U0000003 ! biopolymer
+xref: SO:0000704
+
+[Term]
+id: CCO:U0000005
+name: protein
+def: "One or more polypeptides which may, or may not, be covalently bonded, and which assume a native secondary and tertiary structure." [SO:0000358]
+disjoint_from: CCO:U0000004
+is_a: CCO:U0000003 ! biopolymer
+xref: SO:0000358
+
+[Term]
+id: CCO:U0000006
+name: transcript
+def: "An RNA synthesized on a DNA or RNA template by an RNA polymerase." [SO:0000673]
+is_a: CCO:U0000003 ! biopolymer
+xref: SO:0000673
+
+[Term]
+id: CCO:U0000007
+name: cell cycle protein
+def: "Cell cycle proteins are polymeric macromolecules composed of one or more long chains of amino acids linked by peptide bonds, usually coiled and folded into complex globular or fibrous structures." [CCO:ea]
+is_a: CCO:U0000005 ! protein
+is_a: CCO:U0000001 ! cell cycle continuant
+
+[Term]
+id: CCO:U0000008
+name: cell cycle gene
+def: "Cell cycle units of heredity which (except for polygenes) may be regarded as the controlling agents in the expression of single phenotypic characters and are usually segments of a chromosome at fixed positions relative to each other." [CCO:ea]
+is_a: CCO:U0000004 ! gene
+is_a: CCO:U0000001 ! cell cycle continuant
+
+[Term]
+id: CCO:U0000009
+name: interaction
+is_a: CCO:U0000002 ! cell-cycle process
+
+[Term]
+id: CCO:U0000010
+name: complex
+def: "Any distinct chemical species in which two or more identical or nonidentical chemical species are associated." [CCO:ea]
+is_a: CCO:U0000001 ! cell-cycle continuant
+
+[Term]
+id: CCO:U0000011
+name: modified protein
+def: "A modified protein" [CCO:ea]
+is_a: CCO:U0000005 ! protein
+
+[Term]
+id: CCO:Y0000025
+name: physical association
+is_a: CCO:U0000009 ! interaction
+
+[Term]
+id: CCO:U0000030
+name: modified protein
+def: "A protein which underwent any sort of modification (e.g. phosphorylation)" [CCO:ea]
+is_a: CCO:U0000005 ! protein
+
+[Term]
+id: CCO:U0000012
+name: cell cycle modified protein
+def: "A cell cycle protein which underwent any sort of modification (e.g. phosphorylation)" [CCO:ea]
+is_a: CCO:U0000011 ! modified protein
+is_a: CCO:U0000007 ! cell cycle protein 
+
+[Typedef]
+id: adjacent_to
+name: adjacent_to
+def: "C adjacent to C' if and only if: given any instance c that instantiates C at a time t, there is some c' such that: c' instantiates C' at time t and c and c' are in spatial proximity" [PMID:15892874]
+comment: Note that adjacent_to as thus defined is not a symmetric relation, in contrast to its instance-level counterpart. For it can be the case that Cs are in general such as to be adjacent to instances of C1 while no analogous statement holds for C1s in general in relation to instances of C. Examples are: nuclear membrane adjacent_to cytoplasm; seminal vesicle adjacent_to urinary bladder; ovary adjacent_to parietal pelvic peritoneum
+is_a: relationship ! relationship
+xref: OBO_REL:adjacent_to
+
+[Typedef]
+id: agent_in
+name: agent_in
+is_a: relationship ! relationship
+xref: OBO_REL:agent_in
+
+[Typedef]
+id: association
+name: association
+def: "C in association with C' produces C'' if and only if for all c belonging to C and c' belongin to C', exists a c'' (belonging to C'') which is the result of the reversible union between c and c'." [CCO:ea]
+comment: Ternary relationship. See http://www.w3.org/TR/swbp-n-aryRelations/ for the OWL equivalent. The dissociation is a reversible splitting into simpler entities.
+is_a: relationship ! relationship
+xref: CCO_REL:association
+
+[Typedef]
+id: catalyses
+name: catalyses
+def: "C catalyses P if and only if for all c (catalyst) belonging to C, exists a p (belonging to P) which chemical reaction rate is increased by c." [CCO:ea]
+comment: C inhibits P if and only if for all c (inhibitor) belonging to C, exists a p (belonging to P) which chemical reaction rate is reduced or prevented by c.
+synonym: "activates" EXACT []
+is_a: relationship ! relationship
+xref: CCO_REL:catalyses
+
+[Typedef]
+id: contained_in
+name: contained_in
+def: "C contained_in C' if and only if: given any instance c that instantiates C at a time t, there is some c' such that: c' instantiates C' at time t and c located_in c' at t, and it is not the case that c *overlaps* c' at t. (c' is a conduit or cavity.)" [PMID:15892874]
+comment: Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation.    If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows:    c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t.    The containment relation on the instance level can then be defined (see definition):
+is_a: relationship ! relationship
+xref: OBO_REL:contained_in
+
+[Typedef]
+id: contains
+name: contains
+is_a: relationship ! relationship
+xref: OBO_REL:contains
+
+[Typedef]
+id: degradates
+name: degradates
+def: "C is degradated (into NIL) if and only if for all c belonging to C, exists c', c'', ... (belonging to C', C'', ...) which are the result of any undesired breakdown of c with impairment or loss of its characteristic properties." [CCO:ea]
+comment: NIL entity must be created.
+synonym: "decomposition" EXACT []
+synonym: "catabolism" EXACT []
+is_a: relationship ! relationship
+xref: CCO_REL:degradates
+
+[Typedef]
+id: derived_into
+name: derived_into
+is_a: relationship ! relationship
+is_transitive: true
+xref: OBO_REL:derived_into
+
+[Typedef]
+id: derives_from
+name: derives_from
+def: "Derivation on the instance level (*derives_from*) holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. We say that one class C derives_from class C' if instances of C are connected to instances of C' via some chain of instance-level derivation relations. Example: osteocyte derives_from osteoblast. Formally: C derives_immediately_from C' if and only if: given any c and any t, if c instantiates C at time t, then there is some c' and some t', such that c' instantiates C' at t' and t' earlier-than t and c *derives_from* c'. C derives_from C' if and only if: there is an chain of immediate derivation relations connecting C to C'." [PMID:15892874]
+comment: Derivation as a relation between instances. The temporal relation of derivation is more complex. Transformation, on the instance level, is just the relation of identity: each adult is identical to some child existing at some earlier time. Derivation on the instance-level is a relation holding between non-identicals. More precisely, it holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. Thus we will have axioms to the effect that from c derives_from c1 we can infer that c and c1 are not identical and that there is some instant of time t such that c1 exists only prior to and c only subsequent to t. We will also be able to infer that the spatial region occupied by c as it begins to exist at t overlaps with the spatial region occupied by c1 as it ceases to exist in the same instant.
+is_a: relationship ! relationship
+is_transitive: true
+xref: OBO_REL:derives_from
+
+[Typedef]
+id: encoded_by
+name: encoded_by
+def: "p is encoded by g where p is a Protein and g a Gene." [CCO:ea]
+synonym: "is_produced_by" EXACT [CCO:ea]
+synonym: "coded_by" EXACT [CCO:ea]
+is_a: relationship ! relationship
+xref: CCO_REL:encoded_by
+
+[Typedef]
+id: codes_for
+name: codes_for
+def: "g encodes for p where g a Gene and p is a Protein." [CCO:ea]
+synonym: "produces" EXACT [CCO:ea]
+synonym: "encodes_for" EXACT [CCO:ea]
+is_a: relationship ! relationship
+xref: CCO_REL:codes_for
+
+[Typedef]
+id: has_agent
+name: has_agent
+def: "As for has_participant, but with the additional condition that the component instance is causally active in the relevant process" [PMID:15892874]
+is_a: relationship ! relationship
+xref: OBO_REL:has_agent
+
+[Typedef]
+id: has_improper_part
+name: has_improper_part
+is_a: part_of ! part_of
+is_reflexive: true
+is_transitive: true
+xref: OBO_REL:has_improper_part
+
+[Typedef]
+id: has_integral_part
+name: has_integral_part
+is_a: part_of ! part_of
+is_reflexive: true
+is_anti_symmetric: true
+is_transitive: true
+xref: OBO_REL:has_integral_part
+
+[Typedef]
+id: has_part
+name: has_part
+is_a: relationship ! relationship
+is_reflexive: true
+is_anti_symmetric: true
+is_transitive: true
+xref: OBO_REL:has_part
+
+[Typedef]
+id: has_participant
+name: has_participant
+def: "P has_participant C if and only if: given any process p that instantiates P there is some continuant c, and some time t, such that: c instantiates C at t and c participates in p at t" [PMID:15892874]
+comment: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
+is_a: relationship ! relationship
+xref: OBO_REL:has_participant
+
+[Typedef]
+id: has_proper_part
+name: has_proper_part
+is_a: part_of ! part_of
+is_transitive: true
+xref: OBO_REL:has_proper_part
+
+[Typedef]
+id: improper_part_of
+name: improper_part_of
+def: "As for part_of, with the additional constraint that subject and object may be identical" [PMID:15892874]
+is_a: part_of ! part_of
+is_reflexive: true
+is_transitive: true
+xref: OBO_REL:improper_part_of
+
+[Typedef]
+id: integral_part_of
+name: integral_part_of
+def: "C integral_part_of C' if and only if: C part_of C' AND C' has_part C" [PMID:15892874]
+is_a: part_of ! part_of
+is_reflexive: true
+is_anti_symmetric: true
+is_transitive: true
+xref: OBO_REL:integral_part_of
+
+[Typedef]
+id: interacts_with
+name: interacts_with
+def: "C interacts_with C' if and only if for all c belonging to C, exists a c' (belonging to C') which plays a role with c'." [CCO:ea]
+is_a: relationship ! relationship
+is_symmetric: true
+is_transitive: true
+xref: CCO_REL:interacts_with
+
+[Typedef]
+id: is_a
+name: is_a
+builtin: true
+def: "For continuants: C is_a C' if and only if: given any c that instantiates C at a time t, c instantiates C' at t. For processes: P is_a P' if and only if: that given any p that instantiates P, then p instantiates P'." [PMID:15892874]
+comment: The is_a relationship is considered axiomatic by the obo file format specification, and by OWL
+synonym: "is_subtype_of" EXACT []
+is_reflexive: true
+is_anti_symmetric: true
+is_transitive: true
+xref: OBO_REL:is_a
+xref: owl:subClassOf
+
+[Typedef]
+id: located_in
+name: located_in
+def: "C located_in C' if and only if: given any c that instantiates C at a time t, there is some c' such that: c' instantiates C' at time t and c *located_in* c'. (Here *located_in* is the instance-level location relation.)" [PMID:15892874]
+comment: Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1.    Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus
+is_a: relationship ! relationship
+is_reflexive: true
+is_transitive: true
+xref: OBO_REL:located_in
+
+[Typedef]
+id: location_of
+name: location_of
+is_a: relationship ! relationship
+is_reflexive: true
+is_transitive: true
+xref: OBO_REL:location_of
+
+[Typedef]
+id: part_of
+name: part_of
+def: "For continuants: C part_of C' if and only if: given any c that instantiates C at a time t, there is some c' such that c' instantiates C' at time t, and c *part_of* c' at t. For processes: P part_of P' if and only if: given any p that instantiates P at a time t, there is some p' such that p' instantiates P' at time t, and p *part_of* p' at t. (Here *part_of* is the instance-level part-relation.)" [PMID:15892874]
+comment: Parthood as a relation between instances: The primitive instance-level relation p part_of p1 is illustrated in assertions such as: this instance of rhodopsin mediated phototransduction part_of this instance of visual perception.    This relation satisfies at least the following standard axioms of mereology: reflexivity (for all p, p part_of p); anti-symmetry (for all p, p1, if p part_of p1 and p1 part_of p then p and p1 are identical); and transitivity (for all p, p1, p2, if p part_of p1 and p1 part_of p2, then p part_of p2). Analogous axioms hold also for parthood as a relation between spatial regions.    For parthood as a relation between continuants, these axioms need to be modified to take account of the incorporation of a temporal argument. Thus for example the axiom of transitivity for continuants will assert that if c part_of c1 at t and c1 part_of c2 at t, then also c part_of c2 at t.    Parthood as a relation between classes: To define part_of as a relation between classes we again need to distinguish the two cases of continuants and processes, even though the explicit reference to instants of time now falls away. For continuants, we have C part_of C1 if and only if any instance of C at any time is an instance-level part of some instance of C1 at that time, as for example in: cell nucleus part_ of cell.
+is_a: relationship ! relationship
+is_reflexive: true
+is_anti_symmetric: true
+is_transitive: true
+xref: OBO_REL:part_of
+
+[Typedef]
+id: participates_in
+name: participates_in
+def: "C participates_in P if and only if: given any continuant c that instantiates C there is some process p, and some time t, such that: p has part c at t" [CCO:ea]
+is_a: relationship ! relationship
+xref: OBO_REL:participates_in
+xref: CCO_REL:participates_in
+
+[Typedef]
+id: preceded_by
+name: preceded_by
+def: "P preceded_by P' if and only if: given any process p that instantiates P at a time t, there is some process p' such that p' instantiates P' at time t', and t' is earlier than t. " [PMID:15892874]
+comment: An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C.    The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
+is_a: relationship ! relationship
+is_transitive: true
+xref: OBO_REL:preceded_by
+
+[Typedef]
+id: precedes
+name: precedes
+is_a: relationship ! relationship
+is_transitive: true
+xref: OBO_REL:precedes
+
+[Typedef]
+id: proper_part_of
+name: proper_part_of
+def: "As for part_of, with the additional constraint that subject and object are distinct" [PMID:15892874]
+is_a: part_of ! part_of
+is_transitive: true
+xref: OBO_REL:proper_part_of
+
+[Typedef]
+id: relationship
+name: relationship
+def: "A relationship between two classes (terms). Relationships between classes are expressed in terms of relations on underlying instances." []
+xref: OBO_REL:relationship
+
+[Typedef]
+id: transformation_of
+name: transformation_of
+def: "Relation between two classes, in which instances retain their identity yet change their classification by virtue of some kind of transformation. Formally: C transformation_of C' if and only if given any c and any t, if c instantiates C at time t, then for some t', c instantiates C' at t' and t' earlier t, and there is no t2 such that c instantiates C at t2 and c instantiates C' at t2." [PMID:15892874]
+comment: When an embryonic oenocyte (a type of insect cell) is transformed into a larval oenocyte, one and the same continuant entity preserves its identity while instantiating distinct classes at distinct times. The class-level relation transformation_of obtains between continuant classes C and C1 wherever each instance of the class C is such as to have existed at some earlier time as an instance of the distinct class C1 (see Figure 2 in paper). This relation is illustrated first of all at the molecular level of granularity by the relation between mature RNA and the pre-RNA from which it is processed, or between (UV-induced) thymine-dimer and thymine dinucleotide. At coarser levels of granularity it is illustrated by the transformations involved in the creation of red blood cells, for example, from reticulocyte to erythrocyte, and by processes of development, for example, from larva to pupa, or from (post-gastrular) embryo to fetus or from child to adult. It is also manifest in pathological transformations, for example, of normal colon into carcinomatous colon. In each such case, one and the same continuant entity instantiates distinct classes at different times in virtue of phenotypic changes.
+is_a: relationship ! relationship
+is_transitive: true
+xref: OBO_REL:transformation_of
+
+[Typedef]
+id: transforms_into
+name: transforms_into
+is_a: relationship ! relationship
+is_transitive: true
+xref: CCO_REL:transforms_into
+
+[Typedef]
+id: has_source
+name: has_source
+def: "o originates from O where o is a gene or gene product and O an organism." [CCO:ea]
+is_a: relationship ! relationship
+xref: CCO_REL:has_source
+
+[Typedef]
+id: source_of
+name: source_of
+def: "O source of o where O is an organism and o a gene or gene product." [CCO:ea]
+is_a: relationship ! relationship
+xref: CCO_REL:source_of
+
+[Typedef]
+id: has_function
+name: has_function
+is_a: relationship ! relationship
+xref: OBO_REL:has_function