diff tools/myTools/bin/sfa/data/cho_2016/network_org.sif @ 1:7e5c71b2e71f draft default tip

Uploaded

--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/tools/myTools/bin/sfa/data/cho_2016/network_org.sif	Wed Dec 22 16:00:34 2021 +0000
@@ -0,0 +1,696 @@
+A20	-	TAK1
+A20	-	IKK
+AA	-	RhoGDI
+AA	-	PLC_g
+AA	+	PKC
+AC	+	cAMP
+Actin	+	PLD
+Actin	+	Vinc
+Akt	+	bcl2
+Akt	-	Casp-9
+Akt	+/-	ASK1
+Akt	-	Rac
+Akt	-	Raf
+Akt	-	PAK
+Akt	+	mdmx
+Akt	+	IKK
+Akt	+	mdm2
+Akt	-	p21
+Akt	-	p27
+alpha_12_13_lig	+	alpha_12_13_R
+alpha_12_13_R	+	alpha_12_13_R
+alpha_12_13_R	+	Ga_12_13
+alpha_12_13_R	+	Palpha_12_13_R
+alpha_12_13_R	+	RalGDS
+alpha_12_13_R	+	Gbg_12_13
+alpha_12_13_R	+	EGFR
+alpha_i_lig	+	alpha_i_R
+alpha_i_R	+	alpha_i_R
+alpha_i_R	+	Palpha_i_R
+alpha_i_R	+	RalGDS
+alpha_i_R	+	Gbg_i
+alpha_i_R	+	EGFR
+alpha_i_R	+	Gai
+alpha_q_lig	+	alpha_q_R
+alpha_q_R	+	alpha_q_R
+alpha_q_R	+	Palpha_q_R
+alpha_q_R	+	Gaq
+alpha_q_R	+	RalGDS
+alpha_q_R	+	Gbg_q
+alpha_q_R	+	EGFR
+alpha_s_lig	+	alpha_s_R
+alpha_s_lig	+	Gai
+alpha_s_R	+	alpha_s_R
+alpha_s_R	+	Palpha_s_R
+alpha_s_R	+	Src
+alpha_s_R	+	RalGDS
+alpha_s_R	-	Gai
+alpha_s_R	+	Gbg_s
+alpha_s_R	+	Gas
+AND_3_4	+	Ral
+APC	-	beta-catenin
+ARF	+	PI5K
+ARF	+	PLD
+ARF	+	PI4K
+Arp_2_3	+	Actin
+ASK1	+	MKK3
+ASK1	+	MKK6
+ASK1	+	Sek1
+ASK1	+	MKK7
+atm	+	e2f1
+atm	-	mdm2
+atm	+	rb
+atm	-	mdmx
+atm	+	p53
+atm	+	BRCA1
+B_Arrestin	+	Src
+B_Arrestin	+	RalGDS
+B_Arrestin	+	GRK
+B_Arrestin	+	PDE4
+B_Arrestin	-	alpha_12_13_R
+B_Arrestin	-	alpha_i_R
+B_Arrestin	-	alpha_q_R
+B_Arrestin	-	alpha_s_R
+B_Parvin	+	Pix_Cool
+bax	+	Smac
+bax	+	CytochromeC
+bcl2	-	p53
+bcl2	-	bax
+beta-catenin	+	CyclinD
+beta-catenin	+	Slug
+beta-catenin	+	MMP
+BRCA1	+	CHK1
+Ca	+	PLA2
+Ca	+	PKC
+Ca	+	CaM
+Ca	+	DGK
+Ca	+	EGFR
+Ca	+/-	IP3R1
+Ca	+	p120RasGAP
+CaM	+	RGS
+CaM	+	Myosin
+CaM	+	CaMKK
+CaM	-	IP3R1
+CaM	+	MLCK
+CaM	+	CaMK
+CaM	+	Ral
+CaM	+	RasGRF_GRP
+CaMK	+	Rap1
+CaMK	+	Tiam
+CaMK	+	PLA2
+CaMKK	+	Akt
+CaMKK	+	CaMK
+cAMP	+	PP2A
+cAMP	+	MKPs
+cAMP	+	PKA
+cAMP	+	Rap1
+Cas	+	Src
+Cas	+	DOCK180
+Cas	+	Nck
+Cas	+	Crk
+Cas	+	AND_3_4
+Casp-3	-	rb
+Casp-3	-	bcl2
+Casp-8	+	Casp-3
+Casp-9	+	Casp-3
+Cbp	+	Csk
+Cdc20	-	CyclinB
+Cdc20	-	CyclinA
+Cdc20	+	Cdh1
+Cdc42	+	Mekk1
+Cdc42	+	Mekk4
+Cdc42	+	MLK2
+Cdc42	+	RasGRF_GRP
+Cdc42	+	MLK1
+Cdc42	+	PAK
+Cdc42	+/-	Rac
+Cdc42	+	MLK3
+Cdc42	+	WASP
+Cdc42	+	PLD
+Cdc42	+	PTEN
+Cdh1	-	Cdc20
+Cdh1	+	CyclinA
+Cdh1	-	CyclinB
+Crk	+	Sos
+Crk	+	PI3K
+Crk	+	DOCK180
+Crk	+/-	WASP
+Csk	-	Src
+cycg	-	atm
+cycg	+	mdm2
+CyclinA	-	CyclinE
+CyclinA	-	p27
+CyclinA	-	Cdh1
+CyclinA	-	e2f1
+CyclinA	-	rb
+CyclinB	+	Cdc20
+CyclinB	-	p27
+CyclinB	-	Cdh1
+CyclinB	-	e2f1
+CyclinD	-	p27
+CyclinD	-	rb
+CyclinE	-	mdm2
+CyclinE	-	rb
+CytochromeC	+	Casp-9
+DAG	+	PKC
+DAG	+	DGK
+DAG	+	RasGRF_GRP
+Daxx	+	ASK1
+DGK	-	DAG
+DNA_damage	+	atm
+DNA_damage	+	p14arf
+DOCK180	+	Rac
+e2f1	+	BRCA1
+e2f1	+	CytochromeC
+e2f1	+	atm
+e2f1	+	p14arf
+e2f1	+	CyclinA
+e2f1	+	CyclinE
+ECM	+/-	Integrins
+ECM	+	PTPPEST
+ECM	+	AC
+ECM	+	Rac
+EGF	+	EGFR
+EGF	-	PTP1b
+EGFR	+	Grb2
+EGFR	+	Shc
+EGFR	+	VAV2
+EGFR	+	Src
+EGFR	+	Nck
+EGFR	+/-	PLC_g
+EGFR	+	p120RasGAP
+EGFR	+	Gab1
+EGFR	-	PP2A
+EGFR	+	PI3K
+EGFR	-	PTP1b
+EGFR	+	DGK
+EGFR	+	Mekk2
+Erk	+	p90RSK
+Erk	-	Stathmin
+Erk	+	Myc
+Erk	-	Sos
+Erk	+	Slug
+Erk	+	MMP
+Erk	-	GRK
+Erk	-	Raf
+Erk	+	Snail
+Erk	+	MKPs
+Erk	+	PLA2
+Erk	-	PDE4
+Erk	+	MLCK
+Erk	+	CyclinD
+ExtPump	-	Ca
+FADD	+	Casp-8
+Fak	+	p190RhoGAP
+Fak	+	Shc
+Fak	+	PLC_g
+Fak	+	Grb2
+Fak	+/-	Csk
+Fak	+	Src
+Fak	+	Trio
+Fak	+	PI5K
+Fak	+	p190RhoGEF
+Fak	+	WASP
+Fak	-	p120RasGAP
+Fak	+	PI3K
+Fak	+	GEFH1
+Fak	+	LARG
+Fak	+	Graf
+Fak	+/-	Fak
+Fak	+	Crk
+Fak	+	Cas
+Fas	+	FasR
+FasR	+	FADD
+FasR	+	Daxx
+Frizzled	-	APC
+Fyn	+	LARG
+Ga_12_13	+	Gbg_12_13
+Ga_12_13	+	p115RhoGEF
+Gab1	+	PI3K
+Gab1	-	Mekk3
+Gab1	+	SHP2
+Gai	+	Gbg_i
+Gai	+	PI4K
+Gai	-	Rap1
+Gai	+	Src
+Gaq	+	PI4K
+Gaq	+	Gbg_q
+Gaq	+	PLC_B
+Gas	+	Gbg_s
+Gas	+	AC
+Gas	+	Src
+Gbg_12_13	+	Csk
+Gbg_12_13	-	Gbg_12_13
+Gbg_12_13	+	GRK
+Gbg_i	-	Gbg_i
+Gbg_i	+/-	Gai
+Gbg_i	+	Cdc42
+Gbg_i	+/-	Rac
+Gbg_i	+	AC
+Gbg_i	+	Csk
+Gbg_i	+	PLC_B
+Gbg_i	+	GRK
+Gbg_i	+	PI3K
+Gbg_i	+	IP3R1
+Gbg_q	-	Gbg_q
+Gbg_q	+	Csk
+Gbg_q	+	GRK
+Gbg_q	+/-	Gaq
+Gbg_s	-	Gbg_s
+Gbg_s	+	GRK
+Gbg_s	+/-	Gas
+GCK	+	Mekk1
+Graf	+/-	Cdc42
+Graf	-	Rho
+Grb2	+	Mekk1
+Grb2	+	Gab1
+Grb2	+	Sos
+Grb2	+	Mekk2
+Grb2	+	PAK
+Grb2	+	WASP
+GRK	+	Palpha_12_13_R
+GRK	+	Palpha_i_R
+GRK	+	Palpha_q_R
+GRK	+	Palpha_s_R
+IkB	-	NF-kappaB
+IKK	-	IkB
+IL1_TNF	+	IL1_TNFR
+IL1_TNFR	+	TAK1
+IL1_TNFR	+	Trafs
+IL1_TNFR	+	FADD
+IL1_TNFR	+	MLK3
+IL1_TNFR	+	Smad2
+IL1_TNFR	+	Mekk3
+ILK	+	Akt
+ILK	-	Integrins
+ILK	+	Myosin
+ILK	+	B_Parvin
+ILK	-	MLCP
+Integrins	+	Fak
+Integrins	+	PTPPEST
+Integrins	+	AC
+Integrins	+	Rac
+IP3	+	IP3R1
+IP3R1	+	Ca
+mdm2	-	mdmx
+mdm2	+	e2f1
+mdm2	-	p21
+mdm2	-	rb
+mdm2	-	p53
+mdmx	+	mdm2
+mdmx	-	p53
+Mek	+	Erk
+Mekk1	+	Mek
+Mekk1	+	MKK7
+Mekk1	+	Sek1
+Mekk2	+	MKK3
+Mekk2	+	Mek
+Mekk2	+	MKK7
+Mekk2	+	Sek1
+Mekk3	+	Mek
+Mekk3	+	MKK3
+Mekk3	+	MKK7
+Mekk3	+	Sek1
+Mekk4	+	MKK7
+Mekk4	+	MKK6
+Mekk4	+	MKK3
+Mekk4	+	Sek1
+MKK3	+	p38
+MKK6	+	p38
+MKK7	+	SAPK
+MKPs	-	SAPK
+MKPs	-	Erk
+MKPs	-	p38
+MLCK	+	Myosin
+MLCP	-	Myosin
+MLK1	+	MKK3
+MLK1	+	MKK7
+MLK1	+	Sek1
+MLK2	+	MKK3
+MLK2	+	MKK7
+MLK2	+	Sek1
+MLK3	+	MKK3
+MLK3	+	MKK6
+MLK3	+	MKK7
+MLK3	+	Sek1
+Myc	+	CyclinD
+Myc	-	p21
+Myc	-	p27
+Myosin	+	Actin
+Nck	+	NIK
+Nck	+	Sos
+Nck	+	WASP
+Nck	+	PAK
+NF-kappaB	+	CyclinD
+NF-kappaB	+	MMP
+NF-kappaB	+	A20
+NF-kappaB	+	IkB
+NIK	+	Mekk1
+p115RhoGEF	+	Rho
+p115RhoGEF	-	Ga_12_13
+p120RasGAP	-	p190RhoGAP
+p120RasGAP	+/-	Ras
+p14arf	-	mdmx
+p14arf	-	mdm2
+p14arf	-	e2f1
+p15	-	CyclinD
+p190RhoGAP	-	Rac
+p190RhoGAP	-	Rho
+p190RhoGAP	+/-	Cdc42
+p21	-	CyclinD
+p21	-	CyclinB
+p21	-	CyclinA
+p21	-	CyclinE
+p27	-	CyclinB
+p27	-	CyclinD
+p27	-	CyclinE
+p27	-	CyclinA
+p38	+	MKPs
+p38	-	Tab_1_2
+p53	-	CyclinB
+p53	-	beta-catenin
+p53	-	cycg
+p53	-	bcl2
+p53	+	wip1
+p53	+	PTEN
+p53	-	p14arf
+p53	+	bax
+p53	+	p21
+p53	-	IKK
+p53	+	mdm2
+p53	-	Slug
+p53	-	Snail
+p53	+	CytochromeC
+p90RSK	+	PDK1
+PA	+	DGK
+PA	-	PLC_g
+PA	+	PI5K
+PAK	+	MKK3
+PAK	+	MKK6
+PAK	-	Stathmin
+PAK	+/-	Rac
+PAK	+	Cdc42
+PAK	+	Mek
+PAK	-	MLCP
+PAK	+	Raf
+PAK	+	Myosin
+PAK	-	MLCK
+Palpha_12_13_R	+/-	alpha_12_13_R
+Palpha_12_13_R	+	B_Arrestin
+Palpha_i_R	+/-	alpha_i_R
+Palpha_i_R	+/-	alpha_q_R
+Palpha_i_R	+	B_Arrestin
+Palpha_q_R	+	B_Arrestin
+Palpha_s_R	+/-	alpha_s_R
+Palpha_s_R	+	B_Arrestin
+PDE4	-	cAMP
+PDK1	+	p90RSK
+PDK1	+	PKC_primed
+PDK1	-	RalGDS
+PDK1	+/-	PAK
+PDK1	+	PKA
+PDK1	+	Akt
+PI3K	+	PIP2_34
+PI3K	+	PIP3_345
+PI3K	+	Mekk2
+PI3K	+	VAV2
+PI3K	-	PIP_4
+PI3K	+/-	PIP2_45
+PI3K	+	Fyn
+PI3K	+	PTEN
+PI4K	+	PIP2_45
+PI4K	+	PIP_4
+PI4K	+	PIP2_34
+PI5K	-	PIP_4
+PI5K	-	PIP2_34
+PI5K	+	PIP2_45
+PI5K	+	PIP3_345
+PIP2_34	+	Pix_Cool
+PIP2_34	+	p120RasGAP
+PIP2_34	+	Tiam
+PIP2_34	+	PIP_4
+PIP2_34	+	PIP3_345
+PIP2_34	+	Akt
+PIP2_45	+/-	Sos
+PIP2_45	+	GRK
+PIP2_45	+	p120RasGAP
+PIP2_45	+	PIP3_345
+PIP2_45	-	Vinc
+PIP2_45	+	Talin
+PIP2_45	+	Tiam
+PIP2_45	+	PLD
+PIP2_45	+	ARF
+PIP2_45	+	IP3
+PIP2_45	+	DAG
+PIP2_45	+	WASP
+PIP2_45	+	PLA2
+PIP2_45	-	RhoGDI
+PIP3_345	+	Pix_Cool
+PIP3_345	-	RalGDS
+PIP3_345	+	PIP2_45
+PIP3_345	+	PLD
+PIP3_345	+	Akt
+PIP3_345	+	RGS
+PIP3_345	+	p120RasGAP
+PIP3_345	+	Gab1
+PIP3_345	+	PLC_g
+PIP3_345	+	Sos
+PIP3_345	+	Tiam
+PIP3_345	+	ILK
+PIP3_345	+	ARF
+PIP3_345	+	DOCK180
+PIP3_345	+	p115RhoGEF
+PIP3_345	+	PLA2
+Pix_Cool	+	Rac
+Pix_Cool	+	Cdc42
+Pix_Cool	+	PTEN
+PKA	+/-	CaMKK
+PKA	+	Src
+PKA	-	Raf
+PKA	-	MLCK
+PKA	+	Rap1
+PKA	+	IP3R1
+PKA	-	PLC_B
+PKA	+/-	MLCP
+PKA	-	PAK
+PKA	+	PDE4
+PKA	-	PTPPEST
+PKA	+	Csk
+PKA	-	Rho
+PKA	+	Gai
+PKA	-	Gas
+PKC	+	PLD
+PKC	+/-	Talin
+PKC	+/-	IP3R1
+PKC	-	PTPPEST
+PKC	+	PI4K
+PKC	-	RalGDS
+PKC	-	RhoGDI
+PKC	+	RKIP
+PKC	+	Tiam
+PKC	-	MLCP
+PKC	+/-	GRK
+PKC	-	PKC_primed
+PKC	+	PTPa
+PKC	+/-	EGFR
+PKC	+/-	AC
+PKC	+	DGK
+PKC_primed	+	PKC
+PKC_primed	+/-	PKC_primed
+PLA2	+	AA
+PLC_B	+	IP3
+PLC_B	+/-	PIP2_45
+PLC_B	+	DAG
+PLC_B	-	Gaq
+PLC_g	+	IP3
+PLC_g	+	Mekk2
+PLC_g	+/-	PIP2_45
+PLC_g	+	DAG
+PLD	+	PA
+PP2A	+	Raf_DeP
+PP2A	-	Mek
+PP2A	-	Erk
+PP2A	+/-	Integrins
+PP2A	-	SAPK
+PP2A	-	PKA
+PP2A	+/-	IP3R1
+PP2A	-	p38
+PP2A	-	Akt
+PP2A	+/-	CaMK
+PP2A	-	PKC
+PTEN	-	Shc
+PTEN	-	Fak
+PTEN	-	PIP2_34
+PTEN	+	PIP2_45
+PTEN	+	PIP_4
+PTEN	-	PIP3_345
+PTP1b	-	PAK
+PTP1b	+/-	EGFR
+PTP1b	+	Src
+PTPa	+	Src
+PTPPEST	-	Crk
+PTPPEST	-	Cas
+PTPPEST	-	WASP
+Rac	+	MLK2
+Rac	+	Mekk4
+Rac	+	Mekk3
+Rac	+	MLK1
+Rac	+	PLD
+Rac	+/-	PI5K
+Rac	+	PAK
+Rac	+	Mekk1
+Rac	-	Cdc42
+Rac	+	MLK3
+Raf	+	Mek
+Raf	-	MLCP
+Raf	-	Raf_Loc
+Raf	-	Raf_Rest
+Raf_DeP	+/-	Raf_DeP
+Raf_DeP	+	Raf_Loc
+Raf_DeP	-	Raf_Rest
+Raf_Loc	+	Raf
+Raf_Loc	-	Raf_DeP
+Raf_Loc	+/-	Raf_Loc
+Raf_Rest	+	Raf_DeP
+Raf_Rest	+/-	Raf_Rest
+Ral	+/-	PLD
+Ral	+	RalBP1
+RalBP1	-	Rac
+RalBP1	+/-	Cdc42
+RalGDS	+	Ral
+Rap1	+	Tiam
+Ras	+	PI3K
+Ras	-	RalGDS
+Ras	+	Tiam
+Ras	+	Mekk1
+Ras	+/-	Sos
+Ras	+	Raf_Loc
+Ras	+	Raf
+RasGRF_GRP	+	Ras
+RasGRF_GRP	+	Rac
+rb	-	mdm2
+rb	-	CyclinA
+rb	-	CyclinE
+rb	-	e2f1
+RGS	-	Gaq
+RGS	-	Gai
+RGS	-	Gas
+Rho	+	PI4K
+Rho	+	PLD
+Rho	-	Rac
+Rho	+	Mekk1
+Rho	+	PTEN
+Rho	+/-	PI5K
+Rho	+	RhoK
+RhoGDI	-	Rac
+RhoGDI	-	Rho
+RhoGDI	-	Cdc42
+RhoK	+	ARHGAP22
+RhoK	+	PI5K
+RhoK	+/-	MLCP
+RhoK	+	Myosin
+RKIP	+	Raf
+RKIP	-	GRK
+SAPK	-	bcl2
+SAPK	+	MKPs
+SAPK	+	MLK2
+Sek1	+	p38
+Sek1	+	SAPK
+Shc	+	Grb2
+Shc	+	Mekk1
+SHP2	+	Ras
+SHP2	-	p120RasGAP
+SHP2	-	Csk
+SHP2	-	Gab1
+SHP2	-	Cbp
+Slug	-	E-cad
+Smac	-	XIAP
+Smad2	+	smad2_4
+smad2_4	+	p15
+smad2_4	+	MMP
+smad2_4	-	E-cad
+smad2_4	+	p27
+smad2_4	+	p21
+Snail	-	E-cad
+Sos	+	Ras
+Src	-	Cdc42
+Src	+	Shc
+Src	+	PI3K
+Src	+	DGK
+Src	-	p120RasGAP
+Src	+	Graf
+Src	+	Raf
+Src	+/-	Csk
+Src	+	Mekk2
+Src	+	Akt
+Src	+	Fak
+Src	-	PP2A
+Src	+	PI5K
+Src	+	Tiam
+Src	-	PTEN
+Src	+	Cbp
+Src	+	Rap1
+Src	+	PLC_g
+Src	-	Talin
+Src	+	WASP
+Src	+	GRK
+Src	-	RhoGDI
+Src	+	p190RhoGAP
+Src	+	PDK1
+Src	+	PAK
+Src	+/-	Integrins
+Src	+	Vinc
+Src	+	Crk
+Src	+	Grb2
+Src	+	Cas
+Stathmin	+	GEFH1
+Stress	+	TAO_1_2
+Stress	-	PTP1b
+Stress	+	Trx
+Stress	+	PTEN
+Tab_1_2	+	TAK1
+TAK1	+	IKK
+TAK1	+	Sek1
+TAK1	+	MKK3
+TAK1	+	NIK
+TAK1	+	MKK6
+Talin	+/-	Integrins
+Talin	+/-	PI5K
+Talin	+	Fak
+Talin	+	Vinc
+TAO_1_2	+	MKK3
+TAO_1_2	+	MKK6
+Tgf-b	+	TGFR
+TGFR	+	Smad2
+Tiam	+	Rac
+Tpl2	+	Mek
+Tpl2	+	Sek1
+Tpl2	+	MKK6
+Tpl2	+	MKK3
+Tpl2	+/-	NIK
+Trafs	+	GCK
+Trafs	+	Mekk1
+Trafs	+	Tpl2
+Trafs	+	Trx
+Trafs	+	Tab_1_2
+Trafs	+	TAK1
+Trafs	+	Mekk3
+Trio	+	Fak
+Trx	+	ASK1
+Trx	-	PKC
+WASP	+	Arp_2_3
+wip1	-	atm
+wip1	+	mdm2
+wip1	-	p14arf
+wip1	+	mdmx
+WNT	+	Frizzled
+XIAP	-	Casp-3
+XIAP	-	Casp-9
+Casp-3	+	Apoptosis
+MMP	+	Metastasis
+Rho	+	Metastasis
+E-cad	-	Metastasis
+CyclinA	+	Proliferation
+CyclinB	+	Proliferation
+CyclinD	+	Proliferation
+CyclinE	+	Proliferation