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diff tools/myTools/bin/sfa/data/steinway_2015/network.sif @ 1:7e5c71b2e71f draft default tip

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author laurenmarazzi
date Wed, 22 Dec 2021 16:00:34 +0000
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--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/tools/myTools/bin/sfa/data/steinway_2015/network.sif	Wed Dec 22 16:00:34 2021 +0000
@@ -0,0 +1,134 @@
+Wnt	+	Frizzled
+GLI	+	SHH
+SMAD	+	SHH
+SHH	-	PTCH
+PTCH	-	SMO
+SMO	+	FUS
+FUS	-	SUFU
+SUFU	-	GLI
+SUFU	-	β-Catenin_nuc
+GLI	+	TGFβ
+GLI	+	Wnt
+GLI	+	SNAI1
+TCF/LEF	+	GLI
+Frizzled	+	DSH
+DSH	-	GSK3β
+GSK3β	-	RAS
+Csn	-	GSK3β
+GSK3β	-	SNAI1
+AKT	-	GSK3β
+GSK3β	+	Dest_compl
+Dest_compl	-	GSK3β
+ERK	-	GSK3β
+AXIN2	+	Dest_compl
+Dest_compl	-	β-Catenin_nuc
+β-Catenin_nuc	+	Dest_compl
+β-Catenin_nuc	+	TCF/LEF
+β-Catenin_nuc	+	SNAI2
+E-Cadherin	-	β-Catenin_nuc
+β-Catenin_nuc	-	β-Catenin_memb
+β-Catenin_memb	-	β-Catenin_nuc
+β-Catenin_memb	+	E-Cadherin
+E-Cadherin	+	β-Catenin_memb
+HGF	+	cMet
+cMet	+	SOS/GRB2
+cMet	+	SRC
+CD44	+	cMet
+TCF/LEF	+	CD44
+TCF/LEF	+	Jagged
+TCF/LEF	+	RAS
+TCF/LEF	+	AXIN2
+TCF/LEF	+	TWIST1
+AXIN2	+	AXIN2
+SNAI2	+	SNAI2
+ERK	+	SNAI2
+TWIST1	+	SNAI2
+SNAI2	-	E-Cadherin
+PDGF	+	PDGFR
+PDGFR	+	SOS/GRB2
+PDGFR	+	SRC
+IGF1R	+	SRC
+EGFR	+	SRC
+FGFR	+	SRC
+SRC	+	RAS
+SRC	+	STAT
+STAT	+	LIV1
+LIV1	+	SNAI1
+Csn	-	βTrCP
+NfκB	+	Csn
+βTrCP	-	SNAI1
+IGF1	+	IGF1R
+IGF1R	+	SOS/GRB2
+RAS	+	DELTA
+SOS/GRB2	+	RAS
+RAS	+	RAF
+RAS	+	PI3K
+PI3K	+	AKT
+RKIP	-	MEK
+ERK	-	RKIP
+ILK	+	AKT
+AKT	+	IKKα
+RAF	+	MEK
+MEK	+	ERK
+ERK	-	SOS/GRB2
+ERK	+	SMAD
+ERK	+	c-fos
+SNAI1	-	RKIP
+EGR1	+	SNAI1
+SNAI1	+	TGFβ
+CSL	+	SNAI1
+LOXL23	+	SNAI1
+Goosecoid	+	SNAI1
+PAK1	+	SNAI1
+SMAD	+	SNAI1
+SNAI1	+	TWIST1
+SNAI1	+	ZEB1
+SNAI1	-	miR200
+SNAI1	+	ZEB2
+SNAI1	+	FOXC2
+SNAI1	-	E-Cadherin
+TWIST1	+	FOXC2
+Goosecoid	+	FOXC2
+FOXC2	-	E-Cadherin
+HEY1	-	E-Cadherin
+TWIST1	-	E-Cadherin
+ZEB1	-	E-Cadherin
+ZEB2	-	E-Cadherin
+E-Cadherin	-	EMT
+EGF	+	EGFR
+EGFR	+	SOS/GRB2
+FGF	+	FGFR
+FGFR	+	SOS/GRB2
+TGFβR	+	SOS/GRB2
+SMAD	+	ILK
+IKKα	+	NfκB
+NfκB	+	TWIST1
+c-fos	+	EGR1
+Jagged	+	NOTCH
+SMAD	+	Jagged
+DELTA	+	NOTCH
+NOTCH	+	NOTCH_ic
+CHD1L	+	CDC42
+NOTCH_ic	+	CSL
+CSL	+	HEY1
+SMAD	+	HEY1
+TGFβR	+	CDC42
+CDC42	+	PAK1
+HIF1α	+	LOXL23
+Goosecoid	+	TWIST1
+HIF1α	+	TWIST1
+TWIST1	+	TGFβ
+miR200	-	ZEB1
+ZEB1	-	miR200
+ZEB2	-	miR200
+miR200	-	ZEB2
+HIF1α	+	ZEB2
+Goosecoid	+	ZEB2
+ZEB2	-	SMAD
+TGFβ	+	TGFβR
+Goosecoid	+	TGFβ
+TGFβR	+	SMAD
+ZEB1	+	SMAD
+HIF1α	+	ZEB1
+Goosecoid	+	ZEB1
+Hypoxia	+	HIF1α