annotate offspring_heterozygosity.xml @ 39:e56023008e36 default tip

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author miller-lab
date Mon, 06 Jul 2015 10:32:24 -0400
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1 <tool id="gd_offspring_heterozygosity" name="Pairs sequenced" version="1.0.0">
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2 <description>: Offspring estimated heterozygosity of sequenced pairs</description>
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3
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4 <command interpreter="python">
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5 #import json
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6 #import base64
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7 #import zlib
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8 #set $ind_names = $input.dataset.metadata.individual_names
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9 #set $ind_colms = $input.dataset.metadata.individual_columns
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10 #set $ind_dict = dict(zip($ind_names, $ind_colms))
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11 #set $ind_json = json.dumps($ind_dict, separators=(',',':'))
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12 #set $ind_comp = zlib.compress($ind_json, 9)
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13 #set $ind_arg = base64.b64encode($ind_comp)
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14 offspring_heterozygosity.py '$input' '$input.ext' '$ind_arg' '$p1_input' '$p2_input' '$output'
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15 </command>
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16
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17 <inputs>
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18 <param name="input" type="data" format="gd_snp,gd_genotype" label="SNP dataset" />
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19 <param name="p1_input" type="data" format="gd_indivs" label="First individuals dataset" />
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20 <param name="p2_input" type="data" format="gd_indivs" label="Second individuals dataset" />
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21 </inputs>
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22
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23 <outputs>
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24 <data name="output" format="txt" />
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25 </outputs>
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26
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27 <requirements>
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28 <requirement type="package" version="0.1">gd_c_tools</requirement>
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29 </requirements>
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30
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31 <!--
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32 <tests>
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33 </tests>
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34 -->
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35
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36 <help>
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37
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38 **Dataset formats**
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39
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40 The input datasets are in gd_snp_, gd_genotype_, and gd_indivs_ formats.
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41 The output dataset is in text_ format.
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42
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43 .. _gd_snp: ./static/formatHelp.html#gd_snp
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44 .. _gd_genotype: ./static/formatHelp.html#gd_genotype
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45 .. _gd_indivs: ./static/formatHelp.html#gd_indivs
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46 .. _text: ./static/formatHelp.html#text
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47
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48 -----
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49
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50 **What it does**
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51
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52 For each pair of individuals, one from each specified set, the program
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53 computes the expected heterozygosity of any offspring of the pair, i.e.,
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54 the probability that the offspring has distinct nucleotides at a randomly
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55 chosen autosomal SNP. In other words, we add the following numbers for
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56 each autosomal SNP where both genotypes are defined, then divide by the
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57 number of those SNPs:
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58
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59 0 if the individuals are homozygous for the same nucleotide
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60
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61 1 if the individuals are homozygous for different nucleotides
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63 1/2 otherwise (i.e., if one or both individuals are heterozygous)
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64
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65 A SNP is ignored if one or both individuals have an undefined genotype
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66 (designated as -1).
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67 </help>
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68 </tool>