# HG changeset patch # User modencode-dcc # Date 1358793331 18000 # Node ID aecff0dd0f164072159f404e6a99e8989b3372ef # Parent 58a1d7ef98ef3ab7d106afcf82cd0d9d08c0750d Uploaded diff -r 58a1d7ef98ef -r aecff0dd0f16 idrToolDef.xml --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/idrToolDef.xml Mon Jan 21 13:35:31 2013 -0500 @@ -0,0 +1,64 @@ + + + + + SCRIPT_PATH + + Consistency Analysis on a pair of narrowPeak files + batch-consistency-analysis.r \$SCRIPT_PATH $input1 $input2 $halfwidth $overlap $option $sigvalue $gtable $rout $aboveIDR $ratio $emSav $uriSav + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +Reproducibility is essential to reliable scientific discovery in high-throughput experiments. The IDR (Irreproducible Discovery Rate) framework is a unified approach to measure the reproducibility of findings identified from replicate experiments and provide highly stable thresholds based on reproducibility. Unlike the usual scalar measures of reproducibility, the IDR approach creates a curve, which quantitatively assesses when the findings are no longer consistent across replicates. In layman's terms, the IDR method compares a pair of ranked lists of identifications (such as ChIP-seq peaks). These ranked lists should not be pre-thresholded i.e. they should provide identifications across the entire spectrum of high confidence/enrichment (signal) and low confidence/enrichment (noise). The IDR method then fits the bivariate rank distributions over the replicates in order to separate signal from noise based on a defined confidence of rank consistency and reproducibility of identifications i.e the IDR threshold. For more information on IDR, see https://sites.google.com/site/anshulkundaje/projects/idr + + +