Mercurial > repos > padge > trimal
view trimal_repo/dataset/example.012.AA.SuperAlignment.phy @ 0:b15a3147e604 draft
"planemo upload for repository https://github.com/inab/trimal commit cbe1e8577ecb1a46709034a40dff36052e876e7a-dirty"
| author | padge |
|---|---|
| date | Fri, 25 Mar 2022 17:10:43 +0000 |
| parents | |
| children |
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22 101184 Cgl --MD-----------------------------------LLGDIVEKDVDEVSEVGELPD Kla --MD-----------------------------------LFGDIVERETV-APDAVSNQG Sba --MD-----------------------------------LLGDIVEKDTF-NAVESNDND Sca --MD-----------------------------------LLGDIVEKDPS-SSTSSANAS Sce --MD-----------------------------------LLGDIVEKDTSDSVESNDNGT Sku --MN-----------------------------------LLGDIVEKDTS-VENNDNDSL Smi --MD-----------------------------------LLGDIVEKDTSDSVESNENDL Spa --MD-----------------------------------LLGDIVEKDTSDSVENNDNDA Zro --K--------------------------------------------------------- Ago --MD-----------------------------------VVGEIVERETA-PAEAPAPDG Skl --MD-----------------------------------LLGDIVEKETVEIQEAPAAPS Cal --MD-----------------------------------FIGEIIEHETE-APKEPTPK- Kwa --MD-----------------------------------LLGDIVEKDVSQGPALESAPA Dha --MD-----------------------------------MLGEIVEHEIE-APKPPQM-- Cdu -MMD-----------------------------------FIGEIIEHETE-TPKEPTPK- Lel --MD-----------------------------------FVGEIIEHEIEEPTAPLAPTT Ctr --M--------------------------------------------------------- Clu --MD-----------------------------------LIGEIVEHDVA-VASPPEPSI Pst --MD-----------------------------------FIGEIVEHEIEAPSLTID--- Cgu --MN-----------------------------------LIGEIVEKEIE-PPAEFKAS- Kpo --MD-----------------------------------LLGDIVEKDVEETPTAEISEN Yli --MD------------------------------------VGDIIERDIEDTPAP----- ----------------GG--------------FPKL--YKPEKVS-SWKARLKRKQQ--- -------------MPTTG--------------FPKL--HQPEKVS-SWKQRLMEKKK--- APIAN--------NSKTG--------------FPEL--YRPKKIS-SWKERLREKRA--- ASTSNQQSSYPSSSATTG--------------FPEL--YKPSKIS-SWKHRLKAKKQ--- LSTN---------NCGTG--------------FPEL--YKPKKIS-SWKERLREKRA--- MSN----------NSKTG--------------FPEL--YKPKKIS-SWKERLREKRA--- LISN---------NSKTG--------------FPEL--YKPKKIS-SWKERLREKRT--- LITN---------NSRTG--------------FPEL--YKPKKIS-SWKERLREKRA--- ------------------------------------------------------------ -------------VQPRG--------------FPEL--YRPAAIS-SWRQRLQKKNG--- ----------------SG--------------FPEL--YQPEKIS-SWKVRLQEKKR--- -------------PTIGG--------------FPELKKLKEKKVS-RWRQKQQQEQS--- ----------------TG--------------FPAL--YEPEKVS-SWKVRLQQKRR--- -------------TAKTG--------------FPDLNKLKEKKVS-KWKQRLESKKV--- -------------PTLGG--------------FPELKKLKEKKVS-RWKQKQQQ------ QGSD---------LLNTG--------------FPDPLNHKKRYNS-RWTMKRGAKPA--- -------------KTENG------------------------------------------ -------------SSSSG--------------FPTLKKFGGKRTS-----RFKKQTD--- -------------VEVGG--------------FPDPSKSREKKVS-RWKKRVQKKGT--- -------------DITSG--------------FPAADLLKKKRAS-KFKSAQKANIT--- TRE----------LSKNG--------------FPEL--YKPEKIS-SWKQRLRAKAA--- --------------------------------LPPMPPKAPSAFKREWKRKPKPAPA--- -----------------------ASQTGKVNELSSSRES--------------------- ---------------------KKQQRSNTGSEPPNANFV-------------------EV -----------------------QRKDSGAKETKKQQVA--------------------- -----------------------QQQQQEQRPATRASPR--------------------- -----------------------QKKKTSGKDAEKQQTS--------------------- -----------------------RQRRTSANEAKKQQST--------------------- -----------------------QKKKSSAKDAENEQVA--------------------- ------------------------QKKTGAKQTEKQQAT--------------------- ------------------------------------------------------------ -----------------------QRRPPAAALAA-------------------------- -------------------RGLKHKKQQATDPEPRAEQA--------------------- ------------------------------TTSPKTTEI--------------------- -----------------------NRAASARTVKPVEKKN--------------------- ---------------------------PEVQQSNPVTTE--------------------- -----------------------EQQQKTASHKPTETRS--------------------- -----------TSKVDDVRIKPVSKGNTTATTTTSTTTT----------------TTTTT ------------------------------------------------------------ -----------------------PVKDQLEKKKNEEKEA--------------------- ----------------------EDAAKPLRESANKVKNK--------------------- ------------------------KAPNNQNDTKPTKNT--------------------- ---------------------MKRSGEDNSNERVRAKPA--------------------- -------------------PAPAPAPAPVNNQAPPAKPT--------------------- -----------MRAVEESAAQRIH------------------------------------ GNDSCFSDDTKTDPNALSEAERIH------------------------------------ ------------TDAPLSEAKSIH------------------------------------ --------------QKTSEAQSIH------------------------------------ ------------TDAPLSEAKSIH------------------------------------ ------------TEAPLSEAKSIH------------------------------------ ------------TDVPVSEARSIH------------------------------------ ------------TDAPLSEAKSIH------------------------------------ ------------------------------------------------------------ -----------------SEAEKIH------------------------------------ ---------AGAPDSTMSEAERIH------------------------------------ ----------------RSEASKIH------------------------------------ ----------ESSKGAESEAERIH------------------------------------ ---------------PKSEAEKIH------------------------------------ ------------------EASKIH------------------------------------ GGSSLLSDNRDEQTEPVSEAEQIN------------------------------------ ----------------LTDLSQLD------------------------------------ ---------------ELSEAEKIN------------------------------------ -----------NVVNDLTEAEKIH------------------------------------ -----------------SEAQKIH------------------------------------ ----ERAVVAEDNEEKRTEAQSIH------------------------------------ --VAGRFQNDYPSDQKLTEAEEIH------------------------------------ ------------------------------------RENLETM----------------- ------------------------------------LQNLAVL----------------- ------------------------------------EENIKVL----------------- ------------------------------------NENLNTL----------------- ------------------------------------NENIKVL----------------- ------------------------------------NENIKVL----------------- ------------------------------------NENIKLL----------------- ------------------------------------NENIKIL----------------- ------------------------------------------------------------ ------------------------------------KENMAYI----------------- ------------------------------------LENIKLM----------------- ------------------------------------QENIEKM----------------- ------------------------------------NENVARM----------------- ------------------------------------QENLDKI----------------- ------------------------------------QENIEKM----------------- ------------------------------------QENIAKL----------------- ------------------------------------KEDVDRA----------------- ------------------------------------RENLEKL----------------- ------------------------------------QENMDKI----------------- ------------------------------------QENLDKI----------------- ------------------------------------MENLNTI----------------- ------------------------------------LENLSKL----------------- ----------------RKMSPEE--IARERQELLESL----------------------- ----------------QSMTPEQ--FERERQELMDSL----------------------- ----------------QEMTDDQ--IISERQDLYDSL----------------------- ----------------QNMTDEQ--IINEQRELLQSL----------------------- ----------------QGMSDEQ--IVQEREDLYNSL----------------------- ----------------QEMTDEQ--IMQERQDLYGSL----------------------- ----------------QEMTDEQ--IIQERKDLYDSL----------------------- ----------------QGMTDEQ--IAQERQDLFDSL----------------------- ------------------------------------------------------------ ----------------EGLSEEQ--RTAERRELLESL----------------------- ----------------MEMSPEQ--LEREKQELLDSL----------------------- ----------------AQMSEEE--ILQEREELLKGL----------------------- ----------------QQMSPQQ--LENERRELLESL----------------------- ----------------SQMTSEE--IEQEQAELLSGL----------------------- ----------------AQMSEEE--ILQEREELLKGL----------------------- ----------------NLMTDAE--IMAERESILKQL----------------------- ----------------LRITSNDDLFENDQRDRKVKF----------------------- ----------------SKMSEGE--IEQERRELLEGL----------------------- ----------------ASMTEEE--ITHEREELLQGL----------------------- ----------------ASMTDAE--IMQEQQELLSGL----------------------- ----------------NNMSDEQ--IMQEKRELFESM----------------------- ----------------AKMSPEE--IEAQRQEIMESM----------------------- -----------------------DPKLIQKLLKNV------------------------- -----------------------NPNVLKSLIARV------------DKKMTSLSLKDGE -----------------------DPKLIASLLKNI-------------NKRA-------- -----------------------NPKLIKNLLANI-------------NKRT-------- -----------------------DPKLIAKLLKNI-------------NKRA-------- -----------------------DPKLIAKLLKNI-------------NKRA-------- -----------------------DPKLVTKLLKNI-------------NKRA-------- -----------------------DPGLIAKLLKNI-------------NKRA-------- --------------------------LVQKLIRNM-------------EKRA-------- -----------------------DPKVVQALYRRL-------------DARA-------- -----------------------DAGVIQGLLKRI-------------GKKQ--KNEPLE -----------------------DPKLIESLIGRS-------------KKRE-------- -----------------------DPKVLHALLKRA-------------AKND--TPKSLE -----------------------DPNLIKSLLKRS-------------EKKE---KSNES -----------------------DPKLIESLIGRS-------------KKRE-------- -----------------------NPKLVQSLIQRL-------------QKRD-KGPTSEG -----------------------DDNIK--------------------TVND-------- -----------------------DPKLISSLLKRA------------------------- -----------------------DPKLIQSLLKRT-------------ESRIQKQADHVH -----------------------DPNLVKNLLKRS-------------TARS-------- -----------------------NPKLIQKLLANI-------------NKRS-------- -----------------------DENVLMALMRRA-------------KIKEDDMEPPQQ ----QKSDKIFAEIE--------------------------------------------- TSRSKPPVPQYAEIE--------------------------------------------- --KDETNTPLFAEIE--------------------------------------------- --EGESSAPLFAEIE--------------------------------------------- --KDENNTPLFAEIE--------------------------------------------- --KEENNAPLFAEIE--------------------------------------------- --KDENNTPLFAEIE--------------------------------------------- --KDENNAPLFAEIE--------------------------------------------- ---SENQQTLFPEVE--------------------------------------------- --AADGTAPLVAEVE--------------------------------------------- SSMSSATTPLFAEIE--------------------------------------------- ATDHEHNGHAHEHAE--------------------------------------------- DSSKPTAAPLFAEID--------------------------------------------- CCNDGHDEHVHAE----------------------------------------------- GTGHGHNGHTHEHAE--------------------------------------------- HKEGSDHTHRHQHAE--------------------------------------------- ------------------------------------------------------------ ----EDRSHSHSE----------------------------------------------- GDSSNHGDHGHEHSE--------------------------------------------- --KDHHDDHQHAE----------------------------------------------- -GKDGESAPLFAEIE--------------------------------------------- EPTVEEPEEVFNKSK--------------------------------------------- ----------------------------GASGTWVGGKNEAVANVD-------------- -----------------------------GPGTWIGGSNKVK------------------ ----------------------------GASGTWVGGNKQGIN----------------- ----------------------------GASGTWVGGKNENFK----------------- ----------------------------GASGTWVGGNKQGIY----------------- ----------------------------GAPGTWVGGNKQGIY----------------- ----------------------------GASGTWVGGNKQGIY----------------- ----------------------------GASGTWVGGNKQGIY----------------- ----------------------------GAPGTWVGGNRENG------------------ ----------------------------GAAGTWVGGTREEP------------------ ----------------------------GAPGTWVGGSREFP------------------ -----------------------------GYHGWIGSMKTSEGLT--------------- ----------------------------GAPGTWIGGSHDIP------------------ -----------------------------GFNGWIGGGRTSDEWA--------------- -----------------------------GYHGWIGSMKTSEGLT--------------- -----------------------------GYNGWIGGMKTERGIQ--------------- ------------------------------------------------------------ -----------------------------GHDGWIGGGKKGV------------------ -----------------------------GYNGWIGGMRTKEGMS--------------- -----------------------------GYDGWIGGARDGSKA---------------- ----------------------------GAPGTWVGGTNDPN------------------ ------------------PVKEEPQSEHAREEPTITEVRDDVKA---------------- -----------------------------------DLPPLD-EDMV-------NRAL--- -----------------------------------DLPKLD-DKAV-------DEAL--- -----------------------------------NLPSLE-DDDV-------NAAL--- -----------------------------------HLPSLS-DDQV-------NKAL--- -----------------------------------DLPPLD-DEDV-------DVAL--- -----------------------------------DLPALE-DEDV-------NAAL--- -----------------------------------DLPPLE-DEDV-------NAAL--- -----------------------------------DLPPLE-DEDV-------NAAL--- -----------------------------------ELPSSS-DEQV-------DKAS--- -----------------------------------MMPRLD-DATV-------DAAL--- -----------------------------------DLPRLD-DDAV-------DKAL--- -----------------------------------DLSQLD-KEDV-------DRAL--- -----------------------------------DLPRLD-DAAV-------DRAL--- -----------------------------------DVTLLD-EKDV-------DKAL--- -----------------------------------DLSQLD-KEDV-------DRAL--- -----------------------------------DLSQLD-KADV-------DKAL--- -----------------------------------EDVNDEDKIEL-------DPNG--- -----------------------------------SLPSLS-TEDV-------NKAL--- -----------------------------------DLSQLD-PEDV-------DKAL--- -----------------------------------DLGHLD-ENDV-------NRAL--- -----------------------------------DLRPMS-DDMV-------DKAL--- -----------------------------------ELEQTKETKEA-------ERSL-GD DLN------------------------ATELPKETSASLP---------KDDESDKQE-- GIN--------------------------SVEVQPLKSVR---------FERDLKKEE-- DIR--------------------------PKSSTNTKHVV---------FEEEEEEEE-- DIQ-------------------NLTLEDEDLPTVEAHTEK---------EQDNDDDDD-- EIR--------------------------PMLGKDAKHVQ---------FEEAGKEKD-- EVR--------------------------PQSSINSTHVQ---------FQEDQEDHE-- DIR------------------------------PNSKHVK---------FDEQDKEEE-- EIK--------------------------PKSGINPKHVQ---------FEEDDDEKN-- GIQ--------------------------SNSKPKEKSVS---------FAEEPSETP-- ---------------------------GAPQASMPEAAPT---------YDLPAP----- GIV--------------------------KKPAEEAKHVK---------FIEDQVPEP-- GIS--------------------SLSLSEPEGGSNTKKVA---------FDDNIKTVK-- GIP-----------------------------ETPSKHVN---------FKCPESVAD-- GIS------------RLNLEDDLKIDKQDNEPKDNSKTVR---------FEDVTTVKY-- GIS-------------------SLSLNESDGNNNSTKKVT---------FDDNIKTVK-- GFD----------------LNLNLDGETKRAGTRARKTVT---------FDDNNLATVDG -------------------------------------------------WEDVDDINE-- GIK----------------------NVRFADEVAPLPVTD---------FEDRESSSK-- GIK----------QLNIKDDFDIEKDNSLKASEKPKKSVT---------FNEVATVSY-- GLN-----------------------DSTKKSVSFAPTID---------YQELDDGEK-- GVE------------------------KLSIKEEEKPNVD---------IVEKEVEIK-- DLK-------------------SSLGAREVKPSDMESKYD---------VEDEDDDDK-- ----------------------SED-----QDIAPPLDDDD------------------- -----------VHNIKPDEYDRTDE-----VPNGTFNDEDD------------------- ----------------------EEE-----EEAN-DDDADD------------------- ------------------------------------DDADD------------------- ----------------------------VEGEGKTNDDVDD------------------- ---------------------------------N-NDDADD------------------- ------------------------------KYNDDVDDVDD------------------- -----------------------------------NDDVDD------------------- --------------------SQLPP-----KESLQDLDEDD------------------- -----------------------------------LEDADD------------------- ------------------LDQPVEY-----PPGA-IEDQDD------------------- -----FEALDDEIELDPNGWEDVTD------VNELVPNNDH------------------- ----------------VESASEEET-----QYTKELPDDDD------------------- ------EDLDANVELDPNGWEDVED-----VNDLITGNIDE------------------- -----FEDLDEGIELDPNGWEDVTD------VNELVPNSDH------------------- EQTVENFTHKGGYLGPQGELELLLE-----PQSE-QEVLDK------------------- ----------------------------------LIPNANS------------------- -------------AVIEVEEGENNV-----PILKGDDEDDE------------------- ------EDLDGGIELDPNGWEDVEDLHEMIPNIPHTNNENE------------------- --------------QNLGTWEDVDD-----VKQL-AVNTNA------------------- -------------------------------ESLEFDDIDD------------------- -----------PATTPGTPKKETKT-----ATASEMDFDSS------------------- --------------VAPL-------------------------------EFQ--VAQTID --------------MAPQ-------------------------------EYQ--FVQSID --------------VAPL-------------------------------DFQ--MAQSID --------------VAPL-------------------------------DYQ--MAQTID --------------IAPL-------------------------------DFQ--MAQCID --------------VAPL-------------------------------DFQ--MAQSID --------------VAPL-------------------------------DFQ--MAQSID --------------IAPL-------------------------------DFQ--MAQSID --------------VAPL-------------------------------DFQ--AAQSVD --------------IAPQ-------------------------------EYQ--FIQQMD --------------IAPQ-------------------------------EYQ--FVQRMD --------------IAPD-------------------------------DYQ--INPDSD --------------VAPQ-------------------------------EYQ--FAQQMD --------------VAHK-------------------------------DYQ--LVNDSD --------------IAPD-------------------------------DYQ--INPDSD --------------VAPK-------------------------------DYQ--IIDSDD --------------IAPE-------------------------------GYQ--LNQDND --------------IAPE-------------------------------GYQ-------- --------------IAPE-------------------------------EYQLLTEEEEN --------------VEPD-------------------------------DQV--APEEYQ --------------VAPL-------------------------------DYQ--MAQSID --------------ATPK-------------------------------KVKFEAKEDGD HM-ANEDL-----------------------------------LKDV------------- HM-SNKDL-----------------------------------LAEV------------- HM-KNEDL-----------------------------------FKDV------------- HM-SNEEL-----------------------------------MDDV------------- HM-KNEEL-----------------------------------FKDV------------- HM-KNEDL-----------------------------------FKDV------------- HM-KNEDL-----------------------------------FKDV------------- HM-KNEDL-----------------------------------FKDV------------- HM-ANQEL-----------------------------------FQDV------------- HM-KDEDL-----------------------------------LRDI------------- HM-SNEEL-----------------------------------LQDV------------- EEGLNNTV---------------------------------------------------- HM-KNEDL-----------------------------------LQDV------------- DENDGSTF---------------------------------------------------- DEGLNNTV---------------------------------------------------- EEMNNDTV---------------------------------------------------- DDDDDEDN-----------------------------------NNTV------------- -ILPQEED-----------------------------------QPEM------------- RM-------------------------------------------DV------------- LLSEEAEN----------------------------------GEEGV------------- HM-ANENL-----------------------------------FKDV------------- EKGKDKAE------------------------------SQKSGVQAV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------HFVA---PKVDENDDDDP---------------------- --------------------HFIK-ARKTMGKEQEYEP---------------------- --------------------HFIK---EENQNEIDLEK---------------------- --------------------HFVK---QENTTE---QL---------------------- --------------------HFIK---EESQNEINLEK---------------------- --------------------HFIK---ERKQIEMDLKK---------------------- --------------------HFIK---EEKQSEIELEK---------------------- --------------------HFIK---ENNQNEADLEK---------------------- --------------------HFMK---PEESE---EEK---------------------- --------------------HFVR-------NETVAPR---------------------- --------------------HFIK-NSSADALEGQFEA---------------------- --------------------HFTK---PKQ------PD---------------------- --------------------HFMR----LNQTQQEFET---------------------- --------------------HFPK----PIQVNTDNEK---------------------- --------------------HFTK---PKQ------PE---------------------- --------------------HFTK---PNNS----DPD---------------------- --------------------HFTK---PKQ------DD---------------------- --------------------HFPK---PKAPKE--DPD---------------------- --------------------HFPK---PKP-----VDD---------------------- --------------------HFPK---PVSDK---DED---------------------- --------------------HFIKYVNPNEENEKEVEK---------------------- --------------------HFPK---PPTFAADDEDP---------------------- -----------------------------LDIN-------------DPEFNEKLHKK--- -----------------------------LDIN-------------DPNFDQELHKK--- -----------------------------LDIN-------------DPDFNDKLHDK--- -----------------------------LDIN-------------DPNFNEKLHER--- -----------------------------LDIN-------------DPNFNDKLHEK--- -----------------------------LDIN-------------DPDFNEKLHEK--- -----------------------------LDIN-------------DPNFNDKLHEK--- -----------------------------LDIN-------------DPDFNDKLHEK--- -----------------------------LRLD-------------DPDFDSKLHDK--- -----------------------------LDIN-------------DPNFDEQLHEK--- -----------------------------LDLN-------------DIKFDEKLHEK--- -----------------------------LDIN-------------DPDFFDKLHEK--- -----------------------------LDIN-------------DPAFDDKLHSK--- -----------------------------LDLN-------------DPEFYDKLHEK--- -----------------------------LDIN-------------DPDFFDKLHEK--- -----------------------------LDIN-------------DPDFFDKLHEK--- -----------------------------LDLN-------------DPDFFDKLHEK--- -----------------------------LDLN-------------DPSFFDKLHEK--- -----------------------------LDLN-------------DPDFYDKLHEK--- -----------------------------LDLD-------------DPNFFDKLHDK--- -----------------------------LDLN-------------DPNFDVKLHEK--- -----------------------------MSID-------------DEDFMEKLHEK--- -------------------------------------------------FFPN------- -------------------------------------------------FFPD------- -------------------------------------------------YFPD------- -------------------------------------------------FFPD------- -------------------------------------------------YFPD------- -------------------------------------------------YFPD------- -------------------------------------------------YFPD------- -------------------------------------------------YFPD------- -------------------------------------------------FFPD------- -------------------------------------------------YFPD------- -------------------------------------------------YFPD------- -------------------------------------------------YYPD------- -------------------------------------------------YFPD------- -------------------------------------------------YYPD------- -------------------------------------------------YYPD------- -------------------------------------------------YYPD------- -------------------------------------------------YYPD------- -------------------------------------------------YFAD------- -------------------------------------------------YYPD------- -------------------------------------------------YYPD------- -------------------------------------------------FFPD------- -------------------------------------------------YFPD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------LPKE------------------------------------- -------------------LPQE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKD------------------------------------- -------------------LPKE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKD------------------------------------- -------------------LPKE------------------------------------- -------------------LPRE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKE------------------------------------- -------------------LPRE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKE------------------------------------- -------------------LPKD------------------------------------- -------------------LPKE------------------------------------- ---------------------------------VDKLKWM-EKL---------------- ---------------------------------PDKLKWM-QQV---------------- ---------------------------------VNKLKWM-QPI---------------- ---------------------------------IDKLQWM-EPV---------------- ---------------------------------VDKLKWM-QPV---------------- ---------------------------------VNKLKWM-QPA---------------- ---------------------------------VNKLKWM-QSV---------------- ---------------------------------VNKLKWM-KSV---------------- ---------------------------------VEKLKWM-XPL---------------- ---------------------------------IDKLEWMRAAE---------------- ---------------------------------VEKMQWM-KPV---------------- ---------------------------------TEKLSWMTQPM---------------- ---------------------------------SDKMAWM-KPV---------------- ---------------------------------THKLSWMTEPL---------------- ---------------------------------TDKLSWMTQPM---------------- ---------------------------------TEKLSWMTKPM---------------- ---------------------------------TEKLSWMTQPM---------------- ---------------------------------TSKLAWMTDPL---------------- ---------------------------------TDKLSWMTKPL---------------- ---------------------------------TSKLSWMTTPV---------------- ---------------------------------VDKLEWM-KPI---------------- ---------------------------------PSKMAWMTDARHRVVEERG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P------------EDKGISTIEDV--TQCRF----------------- ------------EN-----------TGKAEEVIHDV--SVCRF----------------- ------------HQ-----------EENKNCIIEDV--FECRF----------------- ------------PDLS-------EETKQDGIVISDV--SQCRF----------------- ------------QQ-----------KTDKNYIIEDV--SECRF----------------- ------------QE-----------ETNRKYVIEDI--TECRF----------------- ------------QQ-----------KTNKSYIIEDV--SECRF----------------- ------------QQ-----------ETNKNCIIEDV--SECRF----------------- ------------PE-----------TKPGDTVIEDV--SQCRF----------------- ------------P------------EQPLASELSDV--AECRF----------------- ------------PE------------NRTDGVLDDV--SLCRF----------------- ------------PK-------------QLSTVYESI--SDMRF----------------- ------------------------LTTKPTGVIDDV--SQCRF----------------- ------------PK-------------QATTTYESI--SDMRF----------------- ------------PK-------------QVSTVYESI--SDMRF----------------- ------------PV-------------QVSTTYESI--SDMRF----------------- ------------PK-------------LTTTTYESI--SDMRF----------------- ------------PQ-------------TRPTTYEAI--SDMRF----------------- ------------PK-------------QTSTTYESV--ADMRF----------------- ------------PQ-------------IVHTTYESV--SDIRF----------------- ------------SDD----------EEQTKTMIDDV--SQLRF----------------- ------------PDGEMTAKIIQDTSDAPLPKTMLP--SEIRF----------------- -----------DFK---------------------------GNL-------------VPP -----------DFK---------------------------GNM-------------VPP -----------DFS---------------------------GNL-------------VPP -----------DFK---------------------------GDL-------------VPP -----------DFN---------------------------GDL-------------VPP -----------DFN---------------------------GNL-------------VPP -----------DFE---------------------------GNL-------------VPP -----------DFN---------------------------GDL-------------VPP -----------DFN---------------------------GNL-------------VPP -----------DFK---------------------------GHM-------------VPP -----------DFK---------------------------GDL-------------VPP -----------DFK---------------------------GDL-------------IEL -----------DFK---------------------------GNL-------------VPP -----------DFK---------------------------GDL-------------VDL -----------DFK---------------------------GDL-------------IEL -----------DFK---------------------------GNL-------------VQI -----------DFK---------------------------GNL-------------IEL -----------DFK---------------------------GEL-------------VRL -----------NFH---------------------------GDL-------------IEL -----------DFK---------------------------GNI-----------VELPD -----------DFK---------------------------GDL-------------VPP -----------DFK---------------------------GNI-------------ITP NRPI----------------DNT-NSGLH-------------------HHSEDQHLAG-- GRKL-----------------TTTNNGLH-------------------HHSDAPELAG-- TRQI----------------ESTVHSGLH-------------------HHSESPELAG-- TRSI----------------QSTTHSALH-------------------HHSTDPQLAG-- TRQI----------------DSTIHSGLH-------------------HHSDSPELAG-- TRQI----------------DSTVRSGLH-------------------HHGDSPELAG-- TRQI----------------DSTIHSGLH-------------------HHSDSPELAG-- TRQI----------------DSTIHSGLH-------------------HHSDSPELAG-- TREI----------------TSTVHSALH-------------------HHSDDPQLAG-- HREV-----------------SSTQTGLH-------------------HHSENPHLAG-- TRKV----------------DST-YTGLH-------------------HHSEDPQLAG-- SAEGEEPKDSSF--------EIPTYMGLH-------------------HHSENPHMAG-- DRPI----------------ETT-KDGLH-------------------HHSEDPGLAG-- TISDSDAKE-----------EIPTYLGLH-------------------HHSENPHLPG-- SAEGEESKGSSS--------DIPTYMGLH-------------------HHSENPHMAG-- NIDKEDVTDSLNGGSREGKGEIPTYLGLH-------------------HHSENPHMAG-- NLEEEEKQQQQNESINK---EIPTYFGLH-------------------HHSDNPHMAG-- DEQSA---------------EIPTHMGLH-------------------HHSENPQLAG-- HDETSPQANPKN--------EIPTYMGLH-------------------HHAENPHLAG-- TKESIN--------------KIPTYLGLH-------------------HHSDSPNLAG-- SREI----------------TSTTHSGLH-------------------HHSDDPQLAG-- KTSR----------------NIPMNLGLH-------------------HHGENPEMAG-- ----------------------------------YTIIE--------------------- ----------------------------------YTIPE--------------------- ----------------------------------YTIVE--------------------- ----------------------------------YTIPE--------------------- ----------------------------------YTIVE--------------------- ----------------------------------YTIVE--------------------- ----------------------------------YTIVE--------------------- ----------------------------------YTIVE--------------------- ----------------------------------YTIPE--------------------- ----------------------------------YTIPE--------------------- ----------------------------------YTILE--------------------- ----------------------------------YTLGE--------------------- ----------------------------------YTILE--------------------- ----------------------------------YTLSE--------------------- ----------------------------------YTLGE--------------------- ----------------------------------YTLSE--------------------- ----------------------------------YTLTE--------------------- ----------------------------------YTIAE--------------------- ----------------------------------YTLAE--------------------- ----------------------------------YTLPE--------------------- ----------------------------------YTIPE--------------------- ----------------------------------YTIPE--------------------- -----------------------------------------LAHLARSQFASQ------- -----------------------------------------LAHLSLSKFPAQ------- -----------------------------------------LEHLARSTFASQ------- -----------------------------------------LQHLARSNFPSQ------- -----------------------------------------LEHLARSTFPSQ------- -----------------------------------------LEHLARSTFSSQ------- -----------------------------------------LEHLARSTFPSQ------- -----------------------------------------LEHLARSTFSSQ------- -----------------------------------------LQRSSRSTFPAQ------- -----------------------------------------LQHLSRSTFPAQ------- -----------------------------------------LQHLSRSTFAAQ------- -----------------------------------------LAHLARSTLAGQ------- -----------------------------------------LQHLSRSSFPSQ------- -----------------------------------------LAHLSRSVLAGQ------- -----------------------------------------LAHLARSTLAGQ------- -----------------------------------------LAHLSRSTQPGQ------- -----------------------------------------LAHLARSTLAAQ------- -----------------------------------------LVHLSRSVVPTQ------- -----------------------------------------LAHLARSVVPSQ------- -----------------------------------------LAHLSRSVVPGQ------- -----------------------------------------LARLTRSTFPQQ------- -----------------------------------------LAQLARSSVSGQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -R----------------AIAIRTLG---------------------------------- -R----------------SIAIQTLG---------------------------------- -R----------------CIAIQTLG---------------------------------- -R----------------CIAIQTLG---------------------------------- -R----------------CIAIQTLG---------------------------------- -R----------------CIAIQTLG---------------------------------- -R----------------CIAIQTLG---------------------------------- -R----------------CIAIQTLG---------------------------------- -R----------------AIAVQTLG---------------------------------- -R----------------CIAIQTLG---------------------------------- -R----------------CIALQTLG---------------------------------- -R----------------CLSIQTLG---------------------------------- -R----------------CIAIQTLG---------------------------------- -R----------------SFSIQILG---------------------------------- -R----------------CLSIQTLG---------------------------------- -R----------------CISIQTLG---------------------------------- -R----------------CISIQTLG---------------------------------- -R----------------CLGIQMLG---------------------------------- -R----------------CVSIQTLG---------------------------------- -R----------------CISIKTLG---------------------------------- -R----------------SISIKILG---------------------------------- -R----------------CIAIRTLG---------------------------------- ---------------------------------RILYKLGKQ------EYNSQLTV---- ---------------------------------RILYKLGKQ------SYAQLVPEVDAE ---------------------------------RILYKLGQK------SYYQLVPEIDSE ---------------------------------RILYKLGKQ------SYYQLIPEVDVE ---------------------------------RILYKLGQK------SYYQLVPEIDAD ---------------------------------RILYKLGQK------SYYQLVPEIDAE ---------------------------------RILYKLGQK------SYYQLVPEIDVE ---------------------------------RILYKLGQK------SYYQLVPEIDAE ---------------------------------RILYKSGKQ------SYYQLVPEVDPE ---------------------------------RILYKLGKQ------SYYQLVPSVDAE ---------------------------------RVLYKLGKQ------SYYQLVPEVDAE ---------------------------------RILHKLGLH------KYS-ILPKTDSD ---------------------------------RILYKLGKQ------SYNQLVPEVDAD ---------------------------------RILHKLGLH------KYNILPVGETE- ---------------------------------RILHKLGLH------KYSILPTTDSG- ---------------------------------RLLHKLGKH------EFNILPINESQG ---------------------------------RILHKLGLH------KYSILPISDQ-- ---------------------------------RILHRLGLH------KYEIMPIVHEED ---------------------------------RILHKLGLH------KYAGVSVEENDE ---------------------------------RILHKLGLH------KYNV-------- ---------------------------------RILYKTGKQ------TYYQLVPEIDSE ---------------------------------RILYRLGNP------TVME-------- ------EVNDESEAEDATKH---------------------------------IYMMFWD ------TYQEEGGSKQIINK---------------------------------IYYMFWD ------TYKEDGSISNVMDK---------------------------------IYSMFWD ------TYQEEGNSENVMLK---------------------------------IYSMFWD ------TYKEDGSISNVMDK---------------------------------IYSMFWD ------TYKEDGSISNVMDK---------------------------------IYAMFWD ------TYKEDGNISNVMDK---------------------------------IYSMFWD ------TYKEDGSISNVMDK---------------------------------IYSMFWD ------TYKEEGSAQGVINK---------------------------------IYSMFWD ------LYQEEGGVEGITSK---------------------------------IYYMFWD ------TYKEEGGTDAIVNR---------------------------------IYAMFWD ------DQSFTDEIKQLSLD---------------------------------FEDMMWD ------TYTEMGGTDAIVNH---------------------------------IYGMFWD ------DQEFNENLTELMSN---------------------------------FENLMWD ------DPSFTDEIKQLSNS---------------------------------FEDMMWD DFGN--ESESDANLKEMMHH---------------------------------FESMMWD ------DEPINEELQQLLNN---------------------------------FENMMWD ------NQLLNDEMKSAMRQ---------------------------------FESMMWD E-----DKHFNENVREMVAS---------------------------------FEKMLWD ---------AAEVSAEINEQ---------------------------------FEDMIWS ------TYSEHGSIKEVMNK---------------------------------IYSMIWD --------------KEYGKT---------------------------------IGMGLRG LVKDT---------------------------------------KVIELLELGSDEK--- VMKDC---------------------------------------KVIETLQLAADES--- LIKDG---------------------------------------KIIESLEIASDEK--- LIKTC---------------------------------------DVILALEVASGAK--- LIKDG---------------------------------------KVIESLEISSDEK--- LVKDG---------------------------------------KIIQSLEIASDEK--- LIKDG---------------------------------------KIIESLEVASNDK--- LVKDG---------------------------------------KIVESLEIASDEK--- SC---------------------------------------------------------- LVKSA---------------------------------------TVIEALQLAADER--- LCKAC---------------------------------------MVIESLEEAADEK--- LIDQL---------------------------------------RIIETITEAADEK--- LCKLS---------------------------------------MVIESLTDAADES--- LIEEL---------------------------------------RIIDSLTEAADES--- LIDQL---------------------------------------RIIETITEAADEK--- LVDEL---------------------------------------RIVESLTEAADEK--- LIDEL---------------------------------------RIIETITDAADEK--- LIDEL---------------------------------------RVIESLTEAADEK--- LIDQL---------------------------------------RVIETITDAADEA--- IVEEL---------------------------------------RIIDTLTEAADEN--- LIKDC---------------------------------------EIIESLQDAANPK--- LIDQG---------------------------------------RVIESITEATHAK--- --------------------------------------YTKSLSIRNY------------ --------------------------------------KTANISVRNY------------ --------------------------------------YTRNLSVRNY------------ -----------------------------------------NLSVKNY------------ --------------------------------------FTRNLSVRNY------------ --------------------------------------FTRNLSVRSY------------ --------------------------------------CTRNLSVRNY------------ --------------------------------------FTRNLSVRNY------------ ------------------------------------------------------------ --------------------------------------TCRHLSVRNY------------ --------------------------------------RTRNISVRNY------------ --------------------------------------KTRNLSVRNY------------ --------------------------------------VTKNLSVRNY------------ --------------------------------------KTRNLSVRNY------------ --------------------------------------KTRNLSVRNY------------ --------------------------------------RTRNLSVRNY------------ --------------------------------------KTTNLSVRNY------------ --------------------------------------KTRNLSVRNY------------ --------------------------------------KTKNLSVRNY------------ --------------------------------------RTKNLSVRNY------------ --------------------------------------RTSHLTVRNY------------ -----------------------------------------QMNVAAY------------ -------------------------------------------------AIEALWLWKQ- -------------------------------------------------AIDALWLWKQ- -------------------------------------------------AIDALWLWKQ- -------------------------------------------------AIDALWLWKQ- -------------------------------------------------AIDALWLWKQ- -------------------------------------------------SIDALWLWKQ- -------------------------------------------------AIDALWLWKQ- -------------------------------------------------AIDALWLWKQ- ------------------------------------------------------------ -------------------------------------------------AIDALWLWRH- -------------------------------------------------AVDALWLWKQ- -------------------------------------------------AIEALWLYRT- -------------------------------------------------AIDALWLWKE- -------------------------------------------------AIEALWLWKQ- -------------------------------------------------AIEALWLYRT- -------------------------------------------------AIEALWLLKT- -------------------------------------------------AIEALWLYKS- -------------------------------------------------AIEALWLWKQ- -------------------------------------------------AIEALWLWKK- -------------------------------------------------ALEALWLWRQ- -------------------------------------------------AIESLWLWKQ- -------------------------------------------------ATEALWLWKQ- ------------G-GGNKYKNK-------------------------------------- ------------G-GGDLRAVSKE------------------------------------ ------------G-GGDFRVKK-------------------------------------- ------------G-GGDFRIKKTDSK---------------------------------- ------------G-GGDFRTKK-------------------------------------- ------------G-GGDFRIKK-------------------------------------- ------------G-GGDFRSKK-------------------------------------- ------------G-GGDFRTKK-------------------------------------- ------------------------------------------------------------ ------------G-GGDPRTTARPTAT--------------------------------- ------------G-GGDFRNKQTTAT---------------------------------- ------------G-GGRPEITKQTEEDLIAQAVQK------------------------- ------------G-GGDFRQNKKNTGK--------------------------------- ------------G-GGRKTSGDKTENSEYIASNMAQ------------------------ ------------G-GGRPETTKQTEEDLIAQAVQK------------------------- ------------G-GGRPAREEIKDAMAIAV----------------------------- ------------G-GGRPKQNSKNELEVITEAVQQL------------------------ ------------G-GGRPEEEKSEQDIIAEQLQGMNT----------------------- ------------G-GGRPEEYEQTE----------------------------------- ------------G-GGRKGRKEKHSIEENIEDYIS------------------------- ------------G-GGDFRKENKPSSTTD------------------------------- ------------G-GSDTRQAS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MSVEHATTIPSPT---DVGA---- ------------------------------------------------------------ ------------------------------------MSSHTNTIIPSPT---DTKA---- ------------------------------------MEDSSNTIIPSPT---DVGA---- ------------------------------------MEDSTNTIIPSPT---DVGA---- ------------------------------------MEDSNNKIIPSPT---DIGA---- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MATKSENTPIYTQASPVVPLPT---DTGA---- ---------------------------------------MSATTIPSPT---DVGA---- ---------------------------MQYKSSGATSKLSQVEIIPAKT---DVGA---- -----------------------------------------MSTIPSPT---DVGA---- --------------------------MSAVQSVGATTKLNQHEILPAPS---DVGA---- ---------------------------MQYKLSGATSKLSQVEIIPAKT---DVGA---- -----------------MASTTSIATEAPVYVAGATTKLSQKEIIPSKT---DVGA---- ----------------------------MALPTGANTKLSQHEILPAKN---DVGA---- -----------------LYSQGLPATYTYIKMSTTTTKLNQQEIIPSRT---DVGA---- --------------------------MSKVQNSGATTKLSQHEILPAKN---DIGA---- ----------------------------MVQTSGATTKLAQHEVVPAPT---DMGA---- ----------------------------------------MTSTIPSPT---DVGA---- -----------------------------------MPKLSQDDILPLPS---DVGA---- -----------------------------MSVRFAVAL----RHGKLYRQGILAFYYVFQ ----------LANRINFQTRDMHNKINAYMSMKMAFAM----RHGFIYRQGIVAYYYVFH -------------------------------------M----RHGFIYRQGILAYYYVFD ----------LANRINFQTRDAHNKINKKMSIKLAIAL----RHGFIYRQGILTYYYIFK ----------LANRINFQTRDAHNKINTFMGIKMAIAM----RHGFIYRQGILAYYYVFD ----------LANRINFHTRDAHNKINTFMGIRMAIAM----RHGFIYRQGILAYYYVFD ----------LANRINFHTRDAHNKINTFMGIKMAIAM----RHGFIYRQGILAYYYVFD ---------------------------------MAIAM----RHGFIYRQGILAYYYVFD ------------------------------------------------------------ ----------LANRINFHTRELHSKADAFVSAKFAVAL----RHPSIYRQGLLAMYYIFR ----------LANRINFHTRDSHNKINADMSVKLAFAM----KHGHIYRQGILAFYYIFA ----------LANRINLETRSLHDRADKTVTLKFALAL----RNYKVYRQGLQAFYHVFA ----------LANRINFYTRDEHNKIDKQMSVKFAFAM----KHGFIYRQGLLAFFYVFQ ----------LANRINHETKALHNNINKLITLKLVLAY----RDSRIYRQGLQSFYHVFA ----------LANRINLETRSLHDRADKTVTLKFAIAI----RNYKVYRQGLQAFYHVFA ----------LANRINTETRSLHDKVDKLVTLKLAIAL----RNYKVFRQGLQAFYHVFA ----------LANRINLETRGLHDKVDKMVTLKLAIAL----RNHKVYRQGLQCFYHVFA ----------LANRINMETRSLHNKIDKLVTLKFALAL----RDYKIFRQGLQSFYHVFA ----------LANRINSETRSLHDKVDKLVTLKMALAL----RDGKIYRQGLQSFYHVFA ----------LANRINKETRTLHNKIDKMMTLKLALAL----RDPKIYRQGLQSFYHVFA ----------LANRINFETRDFHNKVSAFMGIRLALAL----KHGFIYREGLVVFYHIFN ----------LANRINKATRGSHSKINNLINLKIVFAL----RDARIYRQGIQAFYHVFK AIEQEIDALL-------SIDTATGATGATDV----------------------------- AIEQEIDRLL-------E----------HPV----------------------------- AIEQEIDRLL-------N----------DAV----------------------------- VVEEEIIKLT-------T----------SPT----------------------------- AIEQEIDRLL-------N----------DPV----------------------------- AIEQEIDRLL-------H----------DPV----------------------------- AIEQEIDRLL-------N----------DPV----------------------------- AIEQEIDRLL-------N----------DPV----------------------------- ------------------------------------------------------------ SVEQHIDRLL-------R----------APA----------------------------- AVEQEIDNLL-------Q----------NAS----------------------------- SIEKALYRQL-------------------------------------------------- AIEQEIDRLL-------Q----------NAQ----------------------------- TVERSLMKQF-------EK----------------------------------------- SIEKALYRQL-------------------------------------------------- SIETSLHHQL-------------------------------------------------- TIEKALYRQF-------------------------------------------------- TIEECLYKQL-------------------------------------------------- SIEKSLHAQL-------------------------------------------------- TIERCLKEQI-------NA----------------------------------------- TIETEIDLVL-------N------------------------------------------ TYEEVWQEEM-------QR----------------------------------------- --SDQ---KLLASKIVKQFWMPE-FRRTEQLYKDLLL---LYSPEYPTSTELDAMLVDHQ --TVQ---DEKVKGILQQFWCEE-FRRSDKLVLDLQV---LYNDEYPGSEQLQEFLDGFQ --SEK---ELQACGILKQFWLED-FRRSTQIYKDLKL---LYSNTFKSTESLNEFLATFE --TSE---EVKIGNLLSKTWIPE-FNRTENLLKDLQL---LYHDEYPTKEALQLFLETNA --TEE---ELQTSTILKQFWLED-FRRSTQIYKDLKL---LYSNTFKSTESLNEFLATFQ --TEK---ELQTSTILKQFWLED-FRRSTQIYKDLKL---LYSNLFKSTESLNEFLAKFE --TGK---ELQTSAILKQFWLED-FRRSTQIYKDLKL---LYSNTFKSTESLNEFLATFE --TEK---EIQTSAILKQFWLED-FRRSTQIYKDLKL---LYSNMFKSTESLNEFLATFQ ------------------------------------------------------------ --TAD---EARIGEILRAFWRPE-FARAPALVQDFEV---YYAAEYSTSAQLHQFLDSYE --TPL---ELQTQKILNQFWCEE-FRRSNMIFQDLEL---LYSKEYSTRTELHAFLDDNV ---EK---KDEWSEMLEQVWKPE-IARAGKAEQDLLF---FYDD------NKEKFIKPI- --TAE---EVQTRDILLQFWVSS-FSRTPRIYQDLKL---LYAKEFPSDEQLSLFLQQNT --------DDEWTELLKQVWKPE-MGRTDKAEQDLMF---YYDD------RREKFESPI- ---EK---KDEWSEMLEQVWKPE-IARAGKAEQDLLF---FYDD------NKEKFIKPI- ---D-TYPDSEWSKMLSQVWKPE-IARKEKAEQDLLF---FYND------DKSKFVDPM- ---EA---NDEWSDMLKQVWKPE-IARAGKAEDDLLF---FYDD------HKEKFISPI- --ENE---DSEWTPLLRNVWKPE-MARREKGQQDLLF---YYDG------RKEKFMTPI- ---EK---DDEWTPMLKSVWKPE-IARREKAEQDLLF---YYDD------RKEKFVNPI- --------NNEWSDMLNEIWKPE-IARTEKCEQDLMF---YYDD------NREKFEKPM- --NQD---DSQMKLILSSFYLDE-FRRKDKILKDLEL---LYYPEFQNDRQLLEFINSDR --TDESGEYTRIAKILQQTWNPA-ITRTGPLTTDLLF---YYG-------SEEKFRDPV- L--PPQLQGFVDMVHATVRQNPVTVLAYCHVMYLALFAGGKVMRSTLYRNTGLFPKF--- L--PAKLQEFVDEIHSNVQKEPHTILAYCHVLYLALFAGGRVMKSNLYRHIGLFPKF--- K--PPLLQQFVDDIHDNIRQEPCTILSYCHVLYLALFAGGKLIRSNLYRRLGLFPNF--- TELPPVLDSFIKYIHQSILENPCSIFAYCHVLYLALFAGGKIIRSKIYKNLGFLPNF--- K--PPLLQQFINNIHENIHKEPCTILSYCHVLYLALFAGGKLIRSNLYRRLGLFPNF--- K--PPLLQQFVNDIHENIRKEPCTILSYCHVLYLALFAGGKLIRSNLYRRLGLFPNF--- K--PPVLQQFVNNIHENIQKEPCTILSYCHVLYLALFAGGKLIRSNLYRRLGLFPNF--- K--PPLLQQFVNEIHENIRKEPCTVLSYCHVLYLALFAGGKLIRSNLYRRLGLFPNF--- ---------------------------------------------NLYRHTGLFPKF--- L--PPRLAAAVADIEAAALRQPWTILAHCHVLYLALFAGGRVMRSALSRQLGLLPRA--- L--PPQQQAFVEYIHQTVREKPYTILAYCHVLYLALFAGGKLMKSNIYRHTGLFPKF--- ---MPAQIEFCKHILEVTEEKPYLLFAYLHVMYLALFAGGRIMRSSVLKATGMYPQR--- L--PPEQQGFVDFVHESVRARPTSILAFCHVLYLALFAGGRVMRSTIYRSTGLFPKF--- ---MSEQIKFVEHIQKVTAEKPYLFIAYLHVMYLGLFAGGRIMRSSISRATGLFPQK--- ---MPAQIEFCKHILEVTEEKPYLLFAYLHVMYLALFAGGRIMRSSVLKATGMYPQR--- ---MIEQIKFANHIKQVTAEKPYLLFAYLHVMYLALFAGGRIMRSSFAKATGMYPRK--- ---MPAQIEFSNHILKATAEKPYLLFAYLHVMYLALFAGGRIMRSSIVKATGMYPHK--- ---MPAQIEFVNHIRQVTSEKPYLLLAYLHVMYLALFAGGRVMRSSISRATGLFPRK--- ---MPEQIAFANHILEGTAEKPYLLFAYLHVMYLALFAGGRIMRSSFAKATGLFPHK--- ---MSEQIDFVNHIVKSSNDKPYLLLAYLHVMYLALFAGGRIMRSSISRATGLFPQK--- FTNSEQLQNFVKYIQTNATEDPCTLLAYCHVLYLALFAGGKIMKSNVTKHLGIFPKF--- ---MPEQRAFVEHIREVCHAQPHLLLAYGHVMYLALFAGGRILRSNVARAVGLFPKV--- -----------------EHLSSKELARKG----------------------------TNF -----------------GHLSPKELVRRA----------------------------TNF -----------------EKLTQKELVKKG----------------------------TNF -----------------NHLSSKEVFEKG----------------------------TNF -----------------EKLSQKELVKKG----------------------------TNF -----------------ERLSQKELVKKG----------------------------TNF -----------------EKLSQKELVKKG----------------------------TNF -----------------EKLSQKELVKKG----------------------------TNF -----------------QHLSPRELVQRG----------------------------TNF -----------------AGLSARETQLRG----------------------------THF -----------------QHLTPEQIVRRG----------------------------TNF -----------------DGLSHDDVVRMG----------------------------TNF -----------------PDLTPEEVVRKG----------------------------TNF -----------------DGLKHEDIIRLG----------------------------ANF -----------------DGLSHEDVVRMG----------------------------TNF -----------------DGLSHEEIVKLG----------------------------TNF -----------------DGLSHDQIVKMG----------------------------TNF -----------------DGLSHGEIVKEG----------------------------SNF -----------------NGLSHEEIVKLG----------------------------TNF -----------------NGLKHEEIVKLG----------------------------TNF -----------------EHLSHKEIIARG----------------------------TNF -----------------PGQSQEEVAAKG----------------------------TNL FTFSDAG--VDVENQLKWQYKKNYELATREALAENDKLEIIDVAKRIFERNMDIIQEIG- FTFSEEG--VDDENRLRWQYKKGYELATRTELTEAEKLRIIEVSQTIFQRNMEVVAEIG- FTFSELG--PTEETRLKWEYKKNYELATRTELTEAQKLKIISVAEGIFDWNFNIVAEIG- FKFGSDG--VIEETKLKLEFKKNYELNTRESLNEKEKSIIIETSKKIFDYNLMAMEELG- FTFSDLG--PTEETRLKWEYKKNYELATRTELTEAQKLQIISVAEGIFDWNFNIVAEIG- FTFSDLG--PTEETRLKLEYKKNYELATRTELTEAQKLQIISVAGGIFDWNFHIVAEIG- FTFSDLG--PTEETRLKLEYKKNYELATRTELTEAQKLQIISVAEGIFDWNFNIVAEIG- FTFSDLG--PTEETRLKWEYKKNYELATRTELTEAQKLQIISVAEGIFDWNFNIVAEIG- FTFSEEG--SEAENKLRWRYKRGYELATRDELTEEQKQKIISVSSEIFQWNMETIAEIG- FTFG-AG--AGEENKARVAYKRAYELATRTALSEAEKADVIDAARADFDHIQAVMAELA- FTFSEEG--ADAEGKLRWEYKKGYELATRKELTEEQKQEIIKVSSEIFDWNMDVIGELG- FTFD-----VPDEDLLRLTYKRDYELVTRNGLTEEQKLEIIEESKYIFEHDVKCVAELE- FTFSDDG--VQAENQLRKEYKRGYELATREGLTEDQKLNILEVAAATFEWNTRVISEIG- YTFD-----VADEDAFRLIYKRDYELVTRSALTEEQKVEIIEESKYIFAQNAKCVSEIE- FTFD-----VPDEDLLRLTYKRDYELVTRNGLTEEQKLEIIEESKYIFEHDVKCVAELE- FTFD-----VADENLLRVIYKRDYELVTRNGLTEEQKQEIIEESKFIFEQNAKCLHELE- FTFD-----VADEDLLRIMYKRDYELVTRNGLTEAQKTEIIEESKYIFSQNAKCITELE- FSFD-----VEDENTFRLLYKRDYELQTRNNLTEEQKLEIIEESKYIFQQNAKCVIELE- FTFD-----VADENLLRMIYKRDYELVTRNGLTEEQKLEIIEESKYIFEQNAKCIVELE- FTFD-----VADENLLRLVYKRDYELLTRSGLTEEQKLEVIEESKYIFEQNGKCVSELE- YQFTDSTNPETTDVKLRWLYKKNYELSTRDELLEQQKLTVIKTSKDVFVMLENCIAEVG- FRFE-----VDDEEALRLEYKRNYELATRNDLTEEEKQDIIAESLDIFKRNTDCVSEIS- -----------------------------------QLNK--------------------- -----------------------------------EINR--------------------- -----------------------------------ELNR--------------------- -----------------------------------SINK--------------------- -----------------------------------ELNR--------------------- -----------------------------------ELNR--------------------- -----------------------------------ELNR--------------------- -----------------------------------ELNR--------------------- -----------------------------------ELNR--------------------- -----------------------------------VRNR--------------------- -----------------------------------EINR--------------------- -----------------------------------KHNM--------------------- -----------------------------------EINR--------------------- -----------------------------------QHNI--------------------- -----------------------------------KHNM--------------------- -----------------------------------NHNL--------------------- -----------------------------------SHNL--------------------- -----------------------------------HHNL--------------------- -----------------------------------AHNM--------------------- -----------------------------------RHNL--------------------- -----------------------------------TRNR--------------------- -----------------------------------AKNT--------------------- ------------EALTNN-KLDLLQYV--------------------------------- ------------AELMGKFSYKLISFL--------------------------------- ------------RELMSKFSFKCVTYV--------------------------------- ------------EQLMSKLNFKMVTYL--------------------------------- ------------RELMGKFSFKCITYL--------------------------------- ------------RELMGKFSFKCVTYV--------------------------------- ------------RELMGKFSFKCVTYV--------------------------------- ------------RELMGKFSFKCVTYI--------------------------------- ------------QELMGSVSFRSLTYL--------------------------------- ------------QELLGSPSYRLLTFL--------------------------------- ------------NELMGKFSFKLVSFI--------------------------------- ------------DKLSGTWTYFLVTRG--------------------------------- ------------QELMGKLSFKLVSFA--------------------------------- ------------ARMSKKWAYIAATKG--------------------------------- ------------DKLSGSWTYFLVTRG--------------------------------- ------------AKIQGSWTYYAVTKG--------------------------------- ------------EKLSGSWTYFLATRG--------------------------------- ------------SRIKSKWSYFFVTRG--------------------------------- ------------ARLKLKWSYLAVTKG--------------------------------- ------------VRLSRKWSYIAATKG--------------------------------- ------------NELMNIFSYKLFTFI--------------------------------- ------------KALAGKFGYKAAQAS--------------------------------- ---FEE-------------------------------------LKFYNKDRSH---QQLV ---SEE-------------------------------------WKYSEKLTPEV--KKLI ---YEE-------------------------------------WMFSKGSASRKAFSTTM ---LEE-------------------------------------WKFNDNFLSKRG-KHLI ---YEE-------------------------------------WMFNKDSATRRALHTVM ---YEE-------------------------------------WMSDKDSAFRKAFNTAM ---YEE-------------------------------------WMFNKESATRKSFNTVL ---YEE-------------------------------------WMFNKDSVNRKVLNTVM ---HEE-------------------------------------WKHTDKLSKNQ--KDLL ---GEE-------------------------------------WRYRTKNSPQ------L ---LEE-------------------------------------WKYSEKLSKEN--KITI -----------------------------------------------------------Y ---IDE-------------------------------------WKHTEKLTRRQ--KSIV -----------------------------------------------------------Y -----------------------------------------------------------Y -----------------------------------------------------------Y -----------------------------------------------------------Y -----------------------------------------------------------Y -----------------------------------------------------------Y -----------------------------------------------------------S ---VEE-------------------------------------WKYNSSISPFL--KKSL -----------------------------------------------------------Y YAVLVLL----------------ALLVLYRIVYR-------------------------- VFALIVF----------------NMVFVYTILRRLI------------------------ LLMLSIT----------------AVWILYYFVRQNFLSVV-------------------- MVVMVLL----------------HMLFAFFILKRFL------------------------ LLVLSII----------------AIWVLYFLVKSFLSIV--------------------- LLMLSII----------------AVWVIYLLVKKNFLSIV-------------------- LLILSII----------------AIWTLYFLVKKSFLSIV-------------------- LLVLSII----------------AIWVLYFLVKKSFLSIV-------------------- VLAVLVV----------------QFLIVYLVLRRILA----------------------- LALAAVL----------------SALFLYAAARVLVARA--------------------- LVIFAIL----------------QFLLAYWLLRKLF------------------------ YAALVLF----------------SLLALIYLRRVVNKLT--------------------- LATGAVI----------------QILVMYWMLRKFL------------------------ YVVLALA----------------ALLVLFYIRRIILHLL--------------------- YAALVLL----------------SLLALLYLRRVVNKLT--------------------- YGVIGLL----------------VILILFYVQRVLFRSL--------------------- YAVIILL----------------CILVFFYLQRIATKLF--------------------- YIAIAIF----------------FVIALVSLRRIYSHVIA-------------------- QALLVIL----------------ALLALEYVRRFIYSFA--------------------- YVLMALL----------------VLAVLYYVRRLVVHAFF-------------------- MFILIII----------------QFTLASVLLNRYI------------------------ KVVLVML----------------ALFVFYSVYSRLF------------------------ ----LEFVSFLLSLLLLQPVLGYRPVIHPKEKTTSEEPKPWIRTVYSTKVEIVTPTVIAG ----M-ILASWLVFSLLSAL-GYRNVIQPKHTTTSETPKPWMRTIYGTQPEIVTPTVIAG ----MRFQDNAFILFFLQYVHGAKQVIRPKEKTTSEEVKPWLRTIYGTVNEIVTPTVIAG ----MKFALYVVGLLFLQEAVAYKKVHRPKVKTTSEEVKPWIRTIYESQVEIVTPTVIAG ----MRFHDSILIFFSLQHVHGARQVVRPKEKTTSEEVKPWLRTVYGSQKELVTPTVIAG ----MRFHDNIFAFFFLQHVHGARQGIRPKEKTTSEEVQNWKRTIYKSIVEIVTPTVIAG ----MRFYDTIFIFSFLQHVDAARQVVRPKQKTTSEKVQPWRRTIYETIPEIVTPTVIAG ----MRFHDSILIFFFLQHVYGARQVVRPKEKTTSEEVKPWLRTIYGTSKELVTPTVIAG ----------------------------------------------------VMDRVI-- ----MMLSGLVYLLLA-QVAVGRREYVRVQTTTTTEELHPWHRTIYGTVKEIVTPTVIAG ----MRSVQQLVLLACLTCVNAYRDVVQPKHKTTSEVPKPWLRTIYSTKKEIVTPTVIAG ----MKVSVLTTFLLSIAVVYARNQAAKTQSSSTVTPPPKWVRTLTDGKVEIVTPTIIQG ----SVLRSVVLVLFAWSVVSGYRNVVKPNQKTTSETPKPWLRTIYSTQKEIVTPTVIAG ----MKLLKLFTLAILAALTKGYQEQQAQKEGSTTKIPKPWARTISSTKVVLVKPTVIAG ----MKVSILTTSLLFIGATYAKNQAAKTQSSSTITPPPKWVRTLNDGKVEIVTPTIIEG ----MKLSLKLVAFTLLAITYAAKQAKKTATSSSETPPPNWVRTV-NGVPEIVRPQIIAG ----MKVSSIAIVAALMAAVYAKNQAAKTQSSTTETPPPKWIRT-YDGKTEIVTPTVIQG ----MKFAYIWGLLVTTCATYKKLQEMKSSPPTTDDGPSPWLRTIYSNKKEIVTPTVIAG ----MKVLSLLALATVLSALYKKQQEAKAALASTSEVPRKWFRTVSSTIVEVVTPTVIAG ----MKLSLAISLFVSVAVQYREKMEAKKKAASTSSKPKAWMRVVYSTKTERVIPTVIAG ----MRTTLFAILLGLLDFVVAYKPVIEPKEKTTTETPKPWVRTIYSGVKEIVTPTIIAG ----MKFSVLLLAGAVLATVKRPPKVFSKKTKTKAHVTKPWLKPTDGGEPMHVTPTVWGD VTFSAKPLATPDPLLPWVSLQKDGRPKTIKPEIKNGHTRKGRPDYSTYFKTATIHKYTYD VTFGHPPKVTPDPLEAWVSLKKDGSPQTIKPQIKNGRTKNPSPDYGTYFKTASVTTYSEE VTFSAKPDPTPNPLKPWVSLKKDGTPQTIKPEIKKGRTQRESPDYSTYFKTASIHTYSYE VTFSGRPAPTPDPLEPWVSLKKDGTPQTIKPELKNGRTKKGRPEYSTYFKTLSVMTYSFE VTFSEKPEETPNPLKPWVSLEHDGRPKTIKPEINKGRTKKGRPDYSTYFKTVSSHTYSYE VTFSAKPEETPNPLKPWVSLGHDGKAKTIKPKIDKGQTKKGTPDYSTYFKTASAHTYSYD VTFSAKPEATPNPLRPWVSLQHDGRPKTIKPEIKKGLTVKGRPDYSTYFKTATHRTYSYD VTFSAKPEETPNPLKPWVSLEHDGRPKTIKPEIKKGQTKKGRPDYKTYFKTAVTHTYSYE --------------------NKNGIPKTIKPEIKNGRTKNGHPDYSTFFKEVHTKTLGYD VTFSLKPDPTPDPLKPWVSLKKDGAPQTIKPEVKKGRTIKGPPDYSTYFKQVSTTTYSYE VTFSAKPQPTKDPLQPWISLDKQGLPKTIKPKMKNGRTENASPDYSTYFKTVTTKTYSYE VTFNAQPPSTTNGLEYWVSLKDDGSPKTIKPQMKNGQIKNGRPDYSTWFQTATTIVYNKE VTFSAQPLPTPNPLQPWVSLNKYGLPETKKPQIKNGRTKDPSPDYGTYFKTKHVKTYSYD VTFSTRPPKTTNGLENWVSLQKDGSPKTIKPEHKGGQIKNGKPDYGTWFGTASIIPMGKD VTFNAQPPTTTNGLEYWVSLKDDGSPKTIKPQMKNGQIKNGRPDYSTWFQTATTIVYNKE VTISAKPPQTTDGLEVWVSLKNDGSPKIIKPEIKNGRTKNGRPNYSTYFQTATTMTYNKE VTFSAQPPTTTNGLEWWVSLKDDGSPKTIKPQNKNGQIKNGRPDYSTWFQTATTITYNKE VTFSAKPPATTDGLEPWISLKKDGSPKTIKPKMKNGKIQNKSPDYNTWFQTPVTRTYTKE VTFGAKPPATTDGMEPWVSLNKNGSPKTVKPAIKNGRTKNASPTYGTWFATATTKVYSKE VTFSAKPPATTDGLEPWISLNKDGSPKTIKPDIKNGRIRKPSPTYGTWFQTASTIVYTPE VTFSAKPPNPPNPLQPWVSLKNDGIPVTIKPQLKNGITKKASPTYSTYFMDVKTHTFSFE ALFRGQRQVGAVP-NPWIKLKKDGQAKTITPKVVKGKTKNAPPEYGDWFHVNRDVTENAR ELKAHNMDPNDVYEEEVWLDEDDTYVSLNPVIRCTPNRYVNKKQDIVEGPFCTPKENSRF QLIEMGIDPEGPHEEEVLADEDLTYLSLNPVIRCTPDRYFNKGKDETSAPFCTPKENADL ELKASNMDPDDVHEEEVFTDEDKTYVSLNPIIRCTPNRYFNKGKDIPSEPFCTPRENSIW DLKAHNMDPNDVHEEEVYVDEDDTYISLNPIIRCTPDRYFYKGKDIPSEPFCTPRENSMW ELKAHNMGPNEVFVEEEYIDEDDTYVSLNPIVRCTPNLYFNKGKDIRSEPFCTPYENSRW ELKAHNMDPNEVFEEVEFIDEDDTYVSLNPIIRCTPHNYFFKGKDISSEPFCTPYHTSRW ELKAHNMDPNEEFEETEYIEEDDTYVSLNPIIRCTPDRYFNKGKDIHSEPFCTPYENSRW DLKAHNMDPNQKHVEEEYIDEDDTYVSLNPVVRCTPDLYFNKGKDIRSEPFCTPYENSRW DLKAENMDYGDVHEEEVFEDEDETYTSLNPIVRCTPKRYFNKGKNIPSEPFCTPHEDSIW ELQAHNMDPNDVHEEEVFTEEDDTYTSLNPLIRCTPDRYFNKGKDVSSAPFCTPREHVDW EVQAHNMDPNDSHVEEKFVDEDDTYVSLNPIIRCTPERYSYKGKNIPSEPFCTPRENSQL QLKAHNMADDEIFEEVKYIQEDLENHLLSPIIRCTPDRYKKKGRDKTTEPFCTPKDDARL DLKAHNMEEDEVHIEENFEDEDKTYVSLNPIIRCTPDRYFNKGKDISSEPFCTPRENVDL DIKAENMEEDEVYEHHEYIAEDPTYHELNPIIRCTPDRYFKRGKHVNSEPFCTPHENQQL QLKAHNMADDEIFEEIKYIPEDLQDHLLNPIIRCTPDRYKKKGKDKSTEPFCTPKDDARL QLKAHNMKDDEIFTEVQYIEEDLEDHLLNPIIRCTPERYQKKGRDKSTEPFCTPKDDVRL QLKAHNMADDEIFEEVKYIQEDLETHLLSPLIRCTPDRYKKKGRDKSTAPFCTPKDNSRL ELQAHNQEDDQIFEHVEYLPEDLTYKMLNPIIRCTPEFYKKKGKDKSSEPFCFPSDNSNW ELKAHNMEEDEVFEDVQHIEEDPYEHSLNPIIRCTPDLYRKKGKDQSSEPFCFPHDNQQW EMGLEHLNEDEVHEEVVYQEEDQTYHSLNPLIRCTPDYYKLKGKDQSPEPFCFPQDSAQL ELEAHNMDPNDVHEEEEFIPEDDTYLKLNPIIRCAPDRYSEKGKNIKSEPFCTPREATEW SAGYKTAHPTDVVVHNEMLDEDPIEASFNPVERCTPEKFIKV-KKQRVGPWCSPQYGKGV KVGSTYFVTWFTKFFEEADKVRLHISYVKEKAREKGYHRRALPATFYTSEWFHNVDGLYA KVDKTYFVSWFTRFFENEDEVRVHLSYVQEKAHDKGYAKREMKATFFSSEWLKNLDGMYP KVGKTYFVTWYTRFFEDADKVRVHLSYVKEKSKEMGNHKRDLPATFFTSELIDNVDGLLP KVGKTYFVSWYTRFLEDVDKVRIHLSYVKEKASEKGYHKRDIPATFFSSEWVKNADGIYP KVDKTYFVTWYTRFFTDADKVRVHLSYVKENPVEKGNYKRDIPATFFSSEWIDNDNGLMP KVGETYFVTWYTRFFEHADEVRVHLSYVKESYADKGNYKRDVKGAFFSYDWIKNVDGLQA KVENTYFVTWYTRFFEDTDQVRVHLSYVKENPVEKGNYKRDIPATFFSSEWIDNVNGLFA KVDHTYFVSWYTRFFEDADQVRVHLSYVKENPREKGNYKRDLPGTFFSSEWIDNLNGLMA NVGKTYFLTWYTHFFRDVERVRIHMAYIREKSNEKGVLKRDPSATFFHSEWIKNADGVYP YAGQTYFITWYTHFFWDAEQARVMLYYVKKGQLRQ---KREPIKPFFRGQWIKNIDGLFA KVGKTYFISWFTRFFEEVEKVRLHLMYVVEKAHEKGYNKRELPAAFFSSEWIDNVDGIYP TKDKTYFVTWYSRFFDEVDKVRIHLSNIKESLKQKGLKKRDTDFSFFTSDWISNDQGYFP TVGKTYFVTWYTRFFKHVDKVRLHVFYVTERAYDKGFKKRELKGNKFSTEWLANVDGVYP KMDKTYFITWFSRYFKDAKKVRVHLSFLKESARQKGLKRSLKESSFFYSDWLDVEEGMFP TKDKTYFITWYSRFFDEVNKVRIHLSNIKESLKQKGLKKRQEDFSFFSSDWISNDQGYYP VMDKTYFITWYSRFFDPVEKVRILFSNIKESFRQKGLKKRDVQNSFYASDWVRNEDGMLP TMGKVYFITWYSRFFDEVKNVRIHLNYISEKWTQKGLKKRDISSNFFKSDPIDVDVGWFA KADKTYFVTWYHRFFDDVKNVRLHLSYVRESLRQKGLKRDEDGKSFFVSDWVAKDEGLLP KKEQTYFITWYSRFFDDVENVKVHLSYVKESAHQKGFKKREEQVSFYSSDWLKKSQGYFP KQEKTYFVTWFSRFFAPVKNVKLHLTYVKEHHMYKGTKRSEHANSFFTSDWIENDKGFYP RVGRTYFVSWFTRFFKNAEKVRVHLMEVPMEAKEKGYHNKRTNDVVHSSDWLKNLEGIYP MLDHVHWFTWYTREFPDAEKVRLHCAYIQG----KALHKREDSSVFHITEWVSNTWGVYP IEPENDWLGKEYERRVVISIQPDYIPDDEFDPLEHGVLLYLIKGTKVAKKTKDELRLEDA LEVREEWLQGSYNKKVVVSVQPKSVPDDEFDPLEHGVVINIILGSKVFKTTKEQLALEDQ IEVKEEWLQNKFERRIVVSVQPANIPDEEFDPLQNGVLLYISMGSKVYKPTKEQLALQDA IEIDEDWLQGQYERRVVVSV---------------------------------HLSM--- VEVRDEWLQDQFDRRIVVSVQPIYISDEDFDPLQYGILLYITKGSKVFKPTKEQLALDDA VEVKEDWLQGEFERSIVVSVQPRYIPEDEFDPLQNGVVLHITKGSRVFKPTKEQLALDEA VEVREEWLQKKYERRIVVSVQPKNIPDEEFDPLHNGVLLYITAGSKVFKPTKEQLALDDA IEVDEDWLQNEFERRIVVSVQPKYIPDEDFNPLQYGVLLHITKGSRVFKPTKEQLALDDA IEILHEWLQGVRTRKIVISVQPETVSDAEFDPLTHGVFVYLDEGSRVYKQTNKELALNDA ITIDEEWLQGQGTRQLMLTVQPSTVADEEFDPVEHGILVRLALPNRVFKAGKQDLKMLDS LEIMEEWLQSKYERQVLLALQPSHIPDEEFQPLEHGMLIKIILGSKVFKTTKEQLALEDA LYIDENWFGSEYWRKVLISIQPDNIPDEEFNVLQNSIVVEIWKGVKVSKDHLTDLKKLEE LEVSEEWLEDTYEKKVLLAIQPIDISDDDFDPWEHGVLSRIILGPRVGKNTKEQLALQDA VTILEEWFGKKWYRKVLISLQPDNVDDEEFDYTKDAVIVEIIKGAVVSKGQFADLKKLEE LFIDENWFGSEYWKKILISIQPDNIPNDQFNFLENSIVVEIWKGVKVSKDHLIDLKKLEE VTILEEWIGNDYEKKVLISIQPDNIPDDEFNVLENSIVVEFWKGSKVGKEDLLDLKKLEE LDISPDWFDKEYWRKVLVTVVPEGYEDEDYDVFQNSIVIEIWKGVKVGKGHLEDLKRLEE ITVDPEWIGDDFYRKISISLQPDTVDDEEFDRMKNFVVVEIAKGAKVAKGHLEDIKKQEE VTVDEKWIGDNYYRKVLISLQPDNIPEEDFDFLEHSLVIEISKGSKVSKEHLVDLKKLEE LTIDPEWLTMKPFRKVMLSLQPDNVSDEDFDPQANFIVIEIAKGAKVGKEHLLDLKKLEE ITPEDAWLEGEHEKKFVISVQPDYISDEDFDPLEYGIFVYILLQSRVYKHSKEQIALENA MEIEEEWLDGEYEQKVAVAIQPDYMDDDEITLLKNSTFVRFRRGAIVQKKDKGRLDLDK- GISDDTWYYVALTIPTLVVVALVFMYFFLYLNKRDFSDITMQEMKKKHRVLGKYSELPQK GITDDTWYYVAMTIPTAVLFAVVFMYFFVQLNARDFSDVKRDALNQKRRVIGKYDELPKS GISDDKWYYVALSIPTVVVIFFVLMYFFLYVNGRDFTDVTRKALNKKRRVLGKYTELPKK --------FQMMNLPIIEWCPIIYNDGFX------------------------------- GITNDQWYYVALSIPTVVVVFFVFMYFFLYVNGRDFTDVTRKALNKKRRVLGKYTELPKK GITNGQWYYVALSIPTVVVIFFVFMYFFLYANGRDFTDVTRNALNKKRRVLGKYTELPKK GITNDQWYYVALSIPTVVVVFFVFMYFFLYVNGRDFTDVTRKALNKKRRVLGKYTELPKK GITNDQWYYVALSIPTVVVIFFVFMYFFLYVNGRDFTDVTRKALNKKRRVLGKYTELPKK GITDDKWYYVVVSIPTAVIVALVLMYFFIIANRSDFSEVTNKGMAKETSCSR-------- GMTDETWYYLLLTLPTIVVFVAALVYFFLQWNRTDFSDISRAAIAKKHRIIGKYDELPNK GISNDSVYYVILTMPLVVVAACVGMYFFLYLNKRDISDVRRYVLSKKHRVIGKYDELPGK KYANRHMYMIMMGLPTCVLIAGFGMWLFVTINKIDLSSIKKRKFARKNTTHKRYDHLPNT GITDDTWYYVAMTIPTVVLIACAAMYFFLYITKRDITAIRQLAVNQRRRVLGKYSELPTK KWKNDGMYYIMMAVPSCVALFGLGMYIFVMINNIDLSHLKKRQSAGRKTTHRRYSELPKN KYSNRNMYMIMMALPTCVLIFGIGMWLFVTINKIDLSNIKKRKFARENTTHKKYDHLPNT KYANRHMYIVMITLPMCVVIAAFGMWLFVTINRVDLSHLKKKKFAREKTTHRRYESLPSA KYANRHIYMMMIALPTCVVLAALGMWLFVRINKIDLSKVKKRKFARDKTSHRRYTELPST RERGDDYYMVMMSLPLCVLVAAFGMYLFVLLNKTDLSFLKKVKFNHKKPKSRKYTELPEG KYNNPGYYYVMMTMPTCVILAAFLMYIFVYMNKVDLSHLKKKKFARKNTTHRKYTALPNE KWDKADIYLIMMTMPTCVAIAGLLMYFFVMVNKTDLSHLRPKRALGRLTNHRRETELPDM GLTGTKWYYIALSMPAAVAVALFCMYVFLRINKREFSDVTNKALKKKHRVIGKYEELPQR --NEEGMMITIITIPSVVVIFACIYVLFTQITARAIPKFK----NQRRRKDGRYENIKNQ TQSSVSGANDVSSLYPPPPPYIKYFTSENVEKLKEYNE----RREEGESAENELDFLIPP SQS-MSDKNEVSSLYPPPPPFIQFFTEENSKLFRECGKDEEKLAKCTTKQREQLKYFVKP TQNSNGTGNEVSSLYPPPPPYVKFFTQTNLEKLPKYKEKTTTDEEQEEEITCALDYLIPP ---PSNDANDVSSLYPPPPPYIKFFTQQNVDKLEKYKEEKQLEGDSEEVFTNELDYLIPP TQNSNDPGNEVSSLYPPPPPYVKFFTQSNLEKLPKYKEKKAANGGSEEEITCALDYLIPP TQNSNDPGNEVSSLYPPPPPYVKFFTQSNLKRLPKYQERKATGGEDEEEITCALDYLIPP TQNSNDPGNEVSSLYPPPPPYVKFFTQSNMEKLTKYKENKAANDRDEEEITCALDYLIPP TQNSNDPGNEVSSLYPPPPPYVKFFTQSNLEKLPKYKEKKVADGSDEEEITCALDYLIPP ---------------------------------RQCDAEV--DQNGEEKIESPMDFLVPP SQS-MSDSNNISSLYPPPPPYVKFFTKDNLERLAEYQSSH--VTTDPEQITCELDFLIPP TQISTDQSNEITALYPPPPPYMKFFTEANLEKLPKYQKTKNGNHSVTDEITCELDFLIPP EHDTTNNEDLISSLYPPPPPYYKFFTKDNLQKLSTWQENNQTNSEENSIPPGELRFLIPP KQVSIAGSNEIAALYPPPPPYIKYFSEENLAKLASENESQ--RDGESQTDNNELAYLVPP DADTSTNEDIISSLYPPPPPYFKYFTEQNLNNLEIWKNKAQDKEDQDIKPPGELKFLVPP EHDTTNNEDLISSLYPPPPPYYKFFTKENLQKLSTWQENNK-VEEDNSIPPGELRFLIPP DTDMSNDEDLISSLYPPPPPFVKFFTPENLTKLQAWKDQQEQEENDSALPPGELQFLIPP ENDSNENEDLISSLYPPPPPYYKFFTQENKRKLSEWEIEQKQPGDETAIPPGELRFLVPP PND--MADELISSLYPPPPPYYKFFTEENVDKFKKWCET---HNVEEELPPGELRFQVPP DNDSTANGDLISSLYPPPPVYVKFFTTENLNKLQEWQRQQNDNETQDTVPPGELRFLVPP NLDMSENEDLISSLYPPPPPYFKFFTEENRAKLEAWQKDHDGKEQSVPEPPGELKFLVPP KSD--------------------------------------------------------- RLDRKKQNEGLLSVYPPPPWYSRYFTDENVAKVKDLQ-----SSDNSQLLEAPLKYLTPP PMPSSGSYRAFGSVWQIKDHLPDLETMGITQLYKKTAVTDYQYKIKELRRLSYSLLLNFV ELPRDGSYRAFGNVWKIKDELPELSQMGIEQLYEPSQGTNYENKIQESKKLMKSLLLNFL PMPKNQQYRAFGSIWQVKDQLPDLETMGLTQLYKKS-STNYQYKVQELRKLLKSLLLNYL KMPKSHQYRAFGSVWQVKDQLPDLESMGITQLYKKSKPTNYQYKIQESRKLLKSLLLNYL PMPKNQQYRAFGSIWQVKDQLPDLESMGLTQLYKKS-STNYQYKIQELRKLLKSLLLNYL PMPKNQQYRAFGSIWQVKDQLPDLESMGLTQLYKKS-STNYQYKIQELRKLLKSLLLNYL PMPKNQQYRAFGSIWQVKDQLPDLESMGLTQLYKKS-STNYQYKIQELRKLLKSLLLNYL PMPKNQQYRAFGSIWQVKDQLPDLESMGLTQLYKKS-STNYQYKIQELRKLLKSLLLNYL PMPKDQ-YRAFGSIWQVKDRLPDLEASGLTQLYKKPDSTDYQYKIQELRRSLKSLSLNFL PVPSAGHYRAFGSVWQVKDELPDLETVGLRNLY---QGNNYQYKIKELHKLLKSLLLNML RIPETGQYRAFGSIWQIKDELPDLKSLGMTQLYSKPSTKNYQYKIQELRKLLKSLLLNFL KQPEGPQYRGYGNIWLFEDKLPNLKDSQWEQLYDAGDNLTSETKIKELHKLMDSLLLNFL PVPADGRYRAFGSVWHVKDELPDLASMGMTQLYRGS-ASSYQDKIRELHRLLRSLLLNFL KQPDADHYRGFGNLWSFEDKLPGLKELGWTQLYKDDELITSNTKIDELHKLMDSLLLNFL KQPEGLQYRGYGNIWLFEDKLPNLKDSQWEQLYTDDENLTSETKIKELHKLMDSLLLNFL SKPSGSQYRGYGNIWSFEDAFPSLKDTQWPQLY---SNLDSRGKIAELHKIMDSLLLNFL KQPDGTQYRGYGNIWLFEDKLPSLKDSQWEQLYVDDDNITSETKIKELHKLMNSLLLNFL KVPSGEQYRGYGSLWALENKLPSLKASGWRQLYNDDDTITSTQKIDELHKLLDSLLLNFL QPPSGTHYRGYGNIWSFEDKLPSLKSANWEQLY---DSITSETKIKELHKLMDSLLLNFL KQPEGTHYRGYGSLWSFEDKLPSLEDSGWKKLYESVDQDTSRAKIHELHKLTDSLLLCFL ---------------------------------------------------------DYL SPPEAGAYHNFGDVWQVNDKLATLEDLGITQVYDGAEGQESGARVLELKKLTKSLLLAFV ELVGVLSVNPELYESKVENIRTILVNIHHLLNEYRPHQSRESLIMLLEEQLEHKKQEVAN ELIGILGVDSSRYEKKLDEIRVIAINIHHLLNEYRPHQSRESLIMLFEEQLEHKRKEMEH ELVGVLSINPDVYERKVEDIRTILVNIHHLLNEYRPHQSRESLIMLLEEQLEYKRGEIRE ELIGVLSINPEIYQQKVENIRTILINIHHLLNEYRPHQSRESLIMLLEEQLEYKKREIKH ELIGVLSINPDMYERKVENIRTILVNIHHLLNEYRPHQSRESLIMLLEEQLEYKRGEIRE ELVGVLSINPDVYERKVEDIRTILVNIHHLLNEYRPHQSRESLIMLLEEQLEYKRGEIRE ELVGVLSINPDIYERKVEDIRTILVNIHHLLNEYRPHQSRESLIMLLEEQLEYKRGEIRE ELVGVLSINPDVYERKVEDIRTILVNIHHLLNEYRPHQSRESLIMLLEEQLEYKRGEIRE ELVGVLSINPESFPNKVDHIRIISVNIHHLLNEYRPH----------------------- ELVSVLSVNPERFPDKVEHIRTILFNIHHLLNEYRPHQSRESLIMLLEEQLEHKKEEIAN ELIGVLSVNPESFPEKLEHIRTILVNIHHLLNEYRPHQSRESLIMLLEEQLEYKKKEIQH ELIGILSIDPIKYDKKIHDINLILININHLLNTYRPHQSRESLIMLLKNQIDYKFLEIDQ ELTGVLSVNPDRFAEKVEHIQTILVNIHHLLNEYRPHQSRESLIMLLEEQLEHKRGEIQH ELIGVVSIDPQQFHYKIEDLKLILININHILNTYRPHQSRESLIMLLRKQIDMKRNEISE ELIGILSIDPIKYEKKIHDINLILININHLLNTYRPHQSRESLIMLLKNQIDYKFLEIDQ ELVGVLSVDPLQFENKVKDMSALLINFNHLLNTYRPHQSRESLIMMLKNKINDKNLEIQE ELIGVLSIDPSKFETKIKDINLILINLNHLLNTYRPHQSRESLIMLLKKQIDHKKNEIAN ELVGSVSVEPAKFYVKIEDLKLILINMNHLLNTYRPHQTRESLIMLLKTQIEAKRAEIQA ELIGLASIDPLQYESKIKDISLILININHLLNTYRPHQSRESLIMLLRKQIDAKRASINQ ELIGIMSIEPQQFHVKIEDLKLILININHILNTYRPHQSRESLIMLLRQNIEQKRSEITE ELVGILSINPELYQEKVENIKTILVNIHHLLNAYRPHQSRESLIMLLEGQVAHKKSEIEH ELTGIMGVSPEQFPAKFEHVRVLLINIHHILNEYRPHQARESLVTLMQQQINDKKQHVEN IELVCQQVTEKLKQVQTLLKESQSQSQSQSQSQSQSLNDTVAGYYEPLFGLSWYPDRLDN INKVCDEVESKLAQL---------------------MLEKLSYFTGELSDLLSWSFDPSS IDQVCKQVQDKLTSIQDTLRASTHPPPSSSP-----NTTASAGFASPFEKLSLFPHSPNL IEQTCDHVREKLSKISD---PKSLD-----------MLRIGHPLMK----YSWFPESENL IEQVCKQVHDKLTSIQDTLRTGSQSPPSSSQ-----NSTTTAGLTSPFEKLSFFPHSSNL IDQVCKQVQDKLTSIQDTLRAEPHSSSPSSL----------------------------- IEQVCKQVQDKLASIQDTLRTKSHSFS---------NSTATAGLTSPFQKLSFFPQSSNL IEQVCKQVQDKLTSIQDTLRTGSQSPPSSSR-----NSTATAGLTSPFEKLSFFPNSSNL -------------------------------------SKMFETTEDPLIGWSLFPQSDNL IHAICDKVQAKLAAMCKQYIADD-------------MRDPFL--------YSLFSDHDSL IEQTCEEVRERLKSMCDKATSDEKSEKVDITQEHKSMNDPLL--------LSLFRHSDNL INKKCLDIKSKIKNLINERITVVSDTTTTKTTGLGDILEKIPVTEDPFLQYRPFPEVPKT IEQVCSEVRAKLQKMLE--TTDTSSVAENAIEEDGD------MLEDPFLKFSPFAKCDNL IDKTSEDIKSKILKLVDTSYIGDQE--DAKCDNDSTLTDFLPFNEDPFLKFRPFPETSTI INKKCHEIKSKIKNLININDGDKNDKRGESGGIDGDIIEKIPLTEDPFLQYRPFPEVPKT IDRVCEDVKRKIRALVQDAQELVSIDPGVEEEDEQDMSLLFPVILDPFEKYRPFPENPTN IDQVCNEIKSKIKKLFDEQIPDVAP---ETTNVDIVLFSKLPITEDPFLKYRPFPENPSN IDNTAEEVKARILSLVQDLLQDEPV---NDSEQESSMLQSYLEDPFW---ARPFPQEPSN VEKVCSEVKQKLLKLTN--IQDVYKDSIVLPDNSDNITSHFPFTEDPFLSLRPFPEHPTN IDKTCDSIRQRIEAIMD--------QDTGQSEVVEPMTSFLPFTNDWLLDYRPFPDKPSN IENVCQEIREKLQGIQQ----GLSN-----------MIKEVQIGMDPFMGYSWFPGSDSL IRQSCDKVRDTIRVLSKQFDQVDEFETGGVTTEEVKQTDPLALTPQPLVDLQPYCEKIGF LWLAHLHEIVYAFIFYQVCQYTIAPKINRYFFGKHYSDTDKKLKLDFDVHTVSMIQAVIS EYYRHLHEALISFVVYQILYPFVVPKLNEWFFKEHYTERDEPDKINFDIHTVSMIQSVVS -ILAHLHEIIISFIFYQIAFSVVAPFLNRVIFRKHYTTHDPLLKVDFDVHTVSMIQAVVT -YLSHAHEIFYSFVFYNVCHQIVAPILNRMFFRSHYSSKDKYVKVDFDVHTVSMIQAAVS -ILAHLHEIIFSFVFYQLAFSVVAPFLNKVVFRKHYTTRDPLLKIDFNVHTVSMIQAVVS -----------------------------------------------------MIQAIVS -ILVHLHEIIFSFIFYQLAFSILAPFLNKVIFRKHYTTRDPLLKIDFDVHTVSMIQAIVS -ILAHLHEIIFSFVFYQLSFSIFAPFLNRVVFRKHYTTRDPLLKIDFDVHTVSMIQAVVS -YXKHLHEISGALLFYIVVYQWVAPYLNRLIFGKHYTSEDSKVKVNFDVHTVSNIQCIVT -LLRHSHEVLVSFLMYQVLYPVVAPAVNRMIFGQHYTRAAPRTRANFDIHTVSTVQAVLC -YLVHLHEIVLSFVFYQILYPIIAPWLNRLFFGKHYTEESRKTKLNFDIHTVSMFQCILS LFQKHWHEIFASFTFYFIIQQLSGPIFSIIMGPRYTK-LSRSTRVNFDVHVTSMVQCFVS -MVRHMPEVVGSFLVYQVLSQWLVPRINAVVFGRRYTEENRNTKLNFDIHTVSMVQCVVS PFVAHWHEIVGSFLMY-VLVQKLSPMVSSRLFGKSYNQLNYKTKINFDIHVVSMVQCVVS LFQRHWHEIFASFTFYFIIQHLSGPIFSIIMGPRYTK-LSKSTRVNFDVHVTSMVQCFVS LIEAHWHEIAASFAFYFVVQNFTRP-VAKAFMKDKYT-LSKGVQADFDVHVTSMVQCVVS EIVKHWHEIAVSFVFYCLVQLLSKPVFTVIMGSKYTK-LSRGTKVNFDVHVTSMVQCFIS HFLAHWHEIVASAAFY-FAIQAASPVVSKRWFGRSYTNLDVKTRLNFDVHVVSMVQCIIS FLEEHWHEVLASFLFYFTAQLLLAPF-STAYFGKTYTQLPHKTKVNFDIHVVSMVQCVIS VFEEHWHEVVLSLLFYG-TIHLLSPFVMSRWMGSHYTTLPKRTRVNFDVHVVSMVQCFIS -YLSHLHEIVYSFVAYTIIYNIVSPVVNRVIFGHYYTHSSRTDKIDFDIHTVSMFQCIVS KLAPHVHEIFLAFSFYQ-MLFLLSGQLSPIIWGKQL-RLSAKNRIDFDIHIVSQFQAFIV IAILLPVLALPFDL-NIATYVNPWCSMVSALSCGYFVWDLALCLRHFSIYGFEFLFHAVG LYLIWPLLWIPFGF-NVATYYNSYASMVSAVSIGYFMWDLYICLRYFKLFGIGFLFHAVA NTVLLPTLATPMHY-NVVTYADSYSSMVSSLSVGYFLWDLTMCMRHFKLYGLEFTGHALG LFIIWPTLFLPNNL-NVVTYHGPLTSMVASLTIGYFLWDLLVCIRYFRVYGFEFLAHAVG NTVLLPTLTTPMHY-NVVTYTDSYSSMVSSLSAGYFIWDLTMCVRYFKLYGLEFTGHAIG NTVLLPTLTTPMHY-NVVTYTDSYSSMVSSLSAGYFIWDLTMCMRHFKLYGIEFTGHAVG NTTLLPTLTTPMHY-NVVTYTDSYSSMVSSLSAGYFIWDLTMCVRYFKLYGLQFTGHAIG NTVLLPTLTTPMHY-NVVTYTDSYSSMVSSLSAGYFIWDLTMCMRYFKLYGIEFTGHAIG WYAIAPVILTPLSL-NVVTYQDDRCAMATALTVGYFLWDLGVCSLHYELYGVEFMAHCLS VGMIWPLLRLPAAL-PVFGFYDEYASLVAATMVGYFVWDVYLCTRYLAVFGPGFLGHALG LVLIYPILFTPLSL-NIATYYDPYSSLVSSLTMGYFMWDLCVCLRHFSLFGVGFLGHACA FALMVPHLNNPHWVNNSLLGSTDFGGLVCALTVGYFIWDLYVCAKYFSLFGVGFLFHGFA LGLTWPILWQPLSL-SLGTYQDPYTSMVAAVTCGYFIWDLWVCLRHLKLFGLGFLGHAVA VLALIPMWNHPTWKNSAVLAYYPYGGFVSSISVGYFLWDLVVCFKYMNLFGAGFLVHAVS FALMVPHLNNPHWANNSLLGSTDFGGLVCAVTMGYFIWDLYVCAKYFSLFGVGFLFHGFA IVLLVIHLGNPHFQNGSLLGTTPFGAMTCAVTTGYFIWDLYVCLRYYSIFGPGFLFHAIA IALLIPHLNNPHLANNSLLGKTDFGGLACALTVGYFIWDIYVCVRYFSLFGVGFLFHGIA IFILLPSWNHPHFQNSSVFGYNGYSGFVSAVSIGYFLWDLYVCLRHFKLFGFGFLLHAFA IGILIPMWNHSHWQNSSILGASNYGGFVAALTIGYFLWDLYVCVRWYSLFGLGFLFHGFA IASLAPMWNHSHWQNSSIEGSTPYGSFVAAITVGYFVWDVIVCTVYFQLFGLGFLVHGLA LILAPLIVTVPKTL-DVSNYYDHLCTLTSAVSLGYFIWDICVCILHYEVSGPAFFAHAII VPLAFLCFNDPILSANIITAYTPWTGFLGSLATGYFVWDLIICARYVNLFGVGFLLHAIC SLVVMLAILTPFCQPWVGKYLLFEASTPFVNMNWYTIQLNKSSNWLNMINGLLLLLTFFG AFAVLTITLHPVCQAWIGRFLSFEASTPFVNINWYIIQLSRGSTWFNVLNGFLLISVFFF STYVFLLSLRPFCQPFIGRFLIYEASTPFVNINWFIMQCNKNSLWFNVVNGLLLMAVFFL SLYVMLLVLKPFCQPWVGKFLLYEASTPFVNINWYIIQITKKCMWINVLNGLVLMATFGL SVYVMLLSLRPFCQPWIGRFLIYEASTPFVNINWFIMQCNKNSLWFNVVNGLLLMTVFFV SVYVMLLSLRPFCQPWIGRFLIYEASTPFVNINWFIMQCNKNCLWFNVVNGLLLMTVFFV SVYVMLLSLRPFCQPWIGRFLIYEASTPFVNINWFIMQCNKNSLWFNVVNGLLLMTVFFL SVYVMLLSLRPFCQPWIGRFLIYEASTPFVNINWFIMQCNKNSLWFNVVNGLLLMTVFFI SLYVVGLTLKPFCLSWAGKFLLFEASTPFVNNNWFITQ--------------------FV SLAVLLSALTPAFQPWLGKFLIFEASTPLVNVNWFITQLATSARWLPVVNGLLLLVTFFC SLFVFYSTLRPFCQSWVGKFLIFEASTPFVNINWYISQLSRTSAWFNVLNGILLIGVFFL AMYAFATGFVPYCQPWAGPFLTFELSTPFVNINWFASKLPAGTEKTIIINGILLMVTFFI ALYVFVLALRPFGQGWVGKFLIFEASTPFVNVNWFISQ--LTRMWLNAINGALLIVVFFV ALFVFGSTLFRFCLPWVPAFLLFELSTPFVNINWFASKMPVSD--TVIVNGILLLVTFFT AMYAFATGFVPYCQPWAGPFLTFELSTPFVNINWFASKLPFSE-KTIIINGILLMVTFFC AMFAFACGFIPYCQPWAGAFLTFELSTPFVNLNWFASHLPAGTEKFIVINGLSLIIVFFF AMYAFLSGLFPYGQPWAGAFLAFEFSTPFVNLNWFASKLPAGTDKFVIINGLLLMATFFV ALYVFVCSLRPYCLPWVPAFLIFELSTPFVNINWFGSRLPKGTDRVILINGLLLLVTFFS AFYVFSCSLIPYCQPWIPAFLLFELSTPFVNINWFASRLPAGTDTFVIVNGLGLLITFFS ALYVFSFCMRPYAQPWIPAFLLFELSTPFVNINWFASKLPVIGSKTFIINGLCLLFTFFT SIYMSAITIKPLFQPWIGAFLLFEASTPFVNVNWYLCALKKEKTWINSLNGLVLMFIFLT ALFVFVQGFRPYVMGMMGHFLMFEMSTPFVNMNWFVSRLPKGTPWFEAANGIALMTVFFG VRIVWGWSCNLLLLRQFWRARYLPYLAGAVVLSLNITMSLLNVLWFSKMLKIAKKMASPS VRLVWGFVAVAILIYEMWQVWDIPLYMTAVILGINVSLDFLNIHWFSKMLKIAKKMANGS VRICWGTLASALLFKQMWNVRDLPKVSAAIMMSLNVFMNLLNVLWFKKMLRIVKKLTKRA VRLCWGSIATLILGRQMWLIKDLPRTSSIAMLVLNVVMNSMNFMWFSKMIRIAKKLANGS VRICWGSIASALLFRQMWKVRDLPKFSAVTMMSLNIFMNLLNVLWFKKMIRIAKKLAKPA VRICWGTIASALLFKQMWNVRDLPKVSAVAMMSLNIFMNWLNVLWFKKMLKIAKKLAKPA VRICWGSIASALLFKQMWNVRDLPKVAGFTMMSLNIFMNFLNVLWFKKMIKIAKKLAKPA VRICWGTIASALLFKQMWKVRDLPKLSAVTMMSLNIFMNFLNVLWFKKMIKIAKKLAKPA KRCF-------------------------------------------------------- VRIVWGVMALIAMDYYVWRQWGTPKLVGLLVPAINFFMTLLNFYWFYKMVRIAKKMVRAS VRIVWGFTAILLLLREMWKVWDLPQWLLLSIIGINILLDSLNVFWLSKMIKIAKKLASGN VRIVWGFYAVSQLAVDMLASLDVNKLLPISLLVLNFLLNSLNVFWFYKMVMIARKKARGQ VRVLWGFSAIILLIGKLWQARALPTWIPMTIVPLNLALDALNLFWLTKMVQIARKMAKGG VRILWGFYSAIVVARDMFAVWDLYKVLPVGTLLLNFTLNILNVYWFYKMLLIAKKKATGK VRIIWGFYAVSQLAVDMLASLDVNKLLPISLLILNFLLNSLNVFWFYKMVMIARKKARGQ VRIVWGLYAISQMAVDMLSSLDVNKLVPLVILSTNSLLNVLNMYWFYKMIRIAKKKARGV VRILWGFYAVYQFALDIRYSLDVSKALPYTLLGLNFLLDCLNVFWFYKMVMIAKKKAGGS VRIVWGLYAVALLAQDLAQVWHDRLIFAVVTFVLNGSLDILNILWFSKMLAIAKKKLRGN VRIAWGFYAAFMVATDMFAVFGTHWFLPVTILGLNLMLDSLNVFWFYKMVMIAKKKIFGK VRILWGFYAVTIVARDMFAVWNNPKFLPVTILGLNITLDVLNVFWFQKMIKIATKKARGN VRLIWGTSCTIALVRETIRVKAMPPIPTLLFLVFVISLNLLNIYWFSKMIKIAMRAMNGT CRIIWGNYWSYVTITNMWKIRAYPIWLPVLNTTSNLTLVSLNFFWFSKMIRILLKKINGS KKQD--MANKSRPRRAAVPYRKYVGGQGYMQNSRYKTTGKRTNKSGEKIIGAKTDSVGND KRVSKIMANKRRPKKVKPPYRKYVGGVGFTHT---------------------------- PPKLD-MVNKSRPKKIKAPYRKYVAGEGFSSTRNDNKAKEATVPDDAELIETPQGSYYYD KNKRD-MANKSRPKKVKAPYRKYVGGQGYITN-NNTTTVTTSTLKDSDIIETPQGLYYYD PTSKLDMANKSRPKKIKAPYRKYVAGEGFSSTRNDNKAKEFTIPEDAELIETPQGSYYYD PAKLD-MANKSRPKKIKAPYRKYVAGEGFSSTRSDNQAKEFTVPDDAELIETPQGSYYYD PTSKLDMANKSRPKKIKAPYRKYVAGEGFSSTRNDNKAKEFTVPDNAELIETPQGSYYYD PISKLDMANKSRPKKIKAPYRKYVAGEGFSSTRNDNKAREFTVPDDAELIETPQGSYYYD ------SQ---------------------------------------------------- KHVAKVMAGKRRPKKARAPYRKYVAGQGFVHT---------------------------- SSGSGK------------------------------------------------------ ESTREAMANKRRPKKTRAPYRRYVYKSNNYLADSDEDEEFEETEQSETLQATNNARFKGA AHKRE-MANKRRPKKIKAPYRKYVGGQGFVRT----------------------QGFTNG KTTKEA------------------------------------------------------ ESTREAMANKRRPKKTRAPYRRYVYKSNNYLAGSDEDEEFEETEQLETLHTTNNARFKRA KSTRQAMANKSRPKKVRAPYRSYKAKKEEKLV----------------------ASVGIE KSTRQAMANKRRPKKIKAPYKRYVYKSNNYATNSDDEEEEDNSNHSETLHATNNARFKGA APVEVI------------------------------------------------------ SHHKKL------------------------------------------------------ TSTRAA------------------------------------------------------ KSTNHTMANKSRPKKVKAPYRKYVGGQGFVRTLGFNNT----------LVPIGDGLYVEE KKDAKV------------------------------------------------------ ILTESDDEGQDEESKTSKRKNRNKRLSSHGRKRSTNLSLEGLTIQDDEVECEPPM-IPMK ------QGFSQIAEENDTTNIQKFNELQINEIRNPSDSEESRLQGDSVRSDVTDY-GGMK EANDTIVKLTRLSNS-KKDRRGHRRSSSS-SSSSHAKEEKDEQMMESEKISSHLLYLRMV ELNESIVHIEKSSLSNAKFNKLKRFIVNRNKDKNNQEMPRTADSTSSSEQLPIQE-QQMT ETNDTIVKLTRLSNE-KKDKKGRKQSPSS-SSTSSSKGEKNGKVIESEEARMHSVSVKMV ETNDTIVKLTRLSNG-KKDKKGYRQLPLS-SLASHTKKEEDGQVIEREKKSINSLSSRMV EANDTIVKLTRLSSN-KKNKKGHKQSPLSPSSSSRPKGEKEGQVMESEKTNTLSLSLRMA KINETIVKLTRLSND-KKEKKGHKQSLLS-SSAPNFQEDKDGKVIENEETSIHSLSLRMV --------------FXXSCWKWECXXXVPRF--------------------------SXF ---YGVSSTESSAHDESGLFPADSGVQVSDDDIARRLVDMTLSASAAFAGGAAPIGHSMV ------------------------------------------------------------ INVQSIYVLSDQIRYQGKMWPWSKFEKVDIL-------QCALQGHNPLYAHTKLEQGLMK SESDTVGAIEELKESQDIIHTPQGTYYYDLKTESVVLLAAPPPLPSDCTKENSTD-GEMV ------------------------------------------MEIRKEEFESALK--MMK INVQSIYVLSDQIRYQGKMWPWSKFEKVDIL-------QCALQGHNPSYAHNGPEQGVMK TQENTHIIHDHLKNLGVQQRPFHNSTKSEIVVDESINNAEALALAPTLAQNQAQDQAYLP IQVQSIYVLSDQSNYQGKMWPWSKFEKTDVL-------QCALQGYNPAYKQLLTDSDIMA ------------------------------------------------------------ -------------------------------------MHQVQQALEVQRYEDS----LMR ------------------MWPRSQFQKVDVLHHCLHRPHNVMQVDLEMSSSP-----LMN QVIDENEYIDDYNSEISKKGKNRRKNSLK-SNRRNSSGNDKRHISDADLLSNMQLGSPMK ------------------------------------------------------------ IPLEIQRRVVKYYFDLVEETEENIMNVMLVSKYWYYLSLGRLYRAPKLSSRNFNAFVETI LPLEIFDLTISMMSPQ-----DIRMNLVLVCRAWYLICIPKLYRTPKLTSRNFLKFVETV LPWEVQHRIIHYLDIPEEEEDGITMNYMLVCRNWYAMCLPKLYFSPALTSKNFNAFVDTI LPWEIQKMILQYSE-------VIEPSFLVVCKTWYHLCIPLLYYSPSLTSKNFNKFVDAI LPWEIQHRIIHYLDIPEKEEKGINMNYLLVCRNWYAMCLPKLYYAPALTSKNFNGFVDTI LPWEVQYRIIHYLDVPQEEENGIIVNYLLVCRNWYGMCLPKLYFAPALTSKNFNAFVDTI LPWELQYRIIHYLDIPGENENGIIMNYLLVCKNWYCMCLPKLYFAPALTSKNFNGFVDTI LPWEVQHRIIHYLSIPEDEEKGINMNYLLVCRNWYFMCLPKLYFAPALTSKNFNGFVDTI XPGLXXXLILQKVD-------RITMQHLLVCRAWYLMCIPLSYKSPQLSSKXXASFVSSI LPWELQFLVLSKCK-------TIETHFMQVCRRWYIMCLPLIYRAPRLSSKNFYKFVETL ------------------------------------------------------------ FPAEIFVHIFEILNAWG----KLKPKYMRVCKLFYLLILPIIYRQPQLKATNFFNFVEAI LPWEIFELILTYCE-------RIEPQFLAVCRHWYHICIPILYRVPKLTSNNFGSFVDAV LPVEIIVYILEILEAKG----KLKPKYLRVCKLFYLIALPMIYRRPTLKATNFFAFVDTI FPAEIFVHIFEILDAWG----KLKPKYMRVCKLFYLLILPILYRQPQLKATNFFNFVEAI LPIELFAYILEIVNANG----DLDPSLMRVCKDFYKIVRPMIYRHPRLKATSFANFVETL FPVEIFVRIFEILNDWG----KLKPKFMRVCKLFYLIILPIIYKTPYLRATNFFNFVDSI ---------------MG----KLKPKHLRLSKLFYVTLLPLFYRRPLLKGNNFLQFVDTL LPVEIMVRIFEMLDVRG----KLKPRFLRVCKLFYLLILPMIYRCPILKATNFFSFVETI MPIEIIERILEILNAWG----KLKARHLRVCKLFYQLVLPMIYRSPYLRATNFFAFVETI VPYEIQKLIIYYCD-------DTPLNFLLVCKAWYWMCLPSFYKSPTLSSRNFNMFVSTI ------------------------------------------------------------ MPGGSKKIDRYRLGDLVQMLDLSTILQSGKNSNVSKLLRRCSNNLLAFTAPQTSFGYAPL LAD-----RKRKTCEHVVHLDLSPIIQSGKNSYVSKVLRRCSKNLVSFTAPQTSFGIAPL ILN-----KKKNLGHYVFELNLSTILQSGRNSFVSKLLRRCCSNLAKFIAPQTSFGYAPL ISN-----KKKKLGEFVQELDLSTILQSGKNSFVSKLLRRCSPGLTKFTAPQTSFGFAPL IIN-----KKKNLGHYVFELNLSTILQSGRNSFVSKLLRRCCSNLTKFIAPQTSFGYAPL IIN-----KKKNLGYYVFELNLSTILQSGRNSFVSKLLRRCCSNLTKFIAPQTSFGYAPL IIN-----KKKNLGHYVYELNLSTILQSGRNSFVSKLLRRCCSNLTKFIAPQTSFGYAPL IIN-----KKKNLGHYVFELNLSTILQSGRNSFVSKLLRRCCSNLTKFIAPQTSFGYAPL VDN-----KKKRLGGNVKDLDLSTISXSGKXSSVSXVLRICXXSXXQFXAPHTSFGYAPF VAA-----RKQNYGQYVVDLDLSMIIQSGKNSFVAKVLRRCSQHLEHFTAPQTSFGIAPL ------------------------------------------------------------ SSN-------KSLGQYIHSLDLSYIIQSGKNAFVAKLMKRAGKNLEILVAPQTSFGLGPL VNN-----RKKRMGENVVELDLSLIIQSGKNSYVSKLLRRCSPKLESFVAPQTSFGYAPL SSN-------KTIGNNIRELDLSYIIQTGKNAFVAKLLKRSRANLEVFVAPQTSFGLGPL SSN-------KSLGQYIHALDLSYIIQSGKNAFVSKLMKRAGKNLEILVAPQTSFGLGPL SSN-------KSLGDYIHSLDLS-FVQSSKNAFVARLLKQTRKNLEDFVAPQTSFGLGPL ASN-------KSLGSYIQSLDLSYIIQSGKNAFVAKLLKRTGKNLKEFVAPQTSFGIGPM SSN-------KTVGNYIRDLDLSFVNQSGKNAYVAKLLKRSRPLLQSFTAPQTSFGLGPL SSS-------KTIGHYIRELDLSYIIQTGKNAFVAKLLKRSRKNLLAFVAPQTSFGLGPL SSK-------KRLGSYIKELDLSYIIQTGKNAFVAKLLKHSRGSLELFVAPQTSFGFGPL IDN-----KKRKFGEYVYELDLSTILQSGKNSHVSKLLRRCSPRLEKFTAPQTSFGYTPL -----------------------------------------------------------M ISLKNCHKLRFLDLGLVSETVKLKDLFKAISNFNELTHLSFPRSSIDCEGFQEFCWPNNL ISLKSCQNLKYLDLGLVSETVNLKELFLAIKNFHELTHLSFPRSSIQCDGYRDFQWPPNL ISLKSCHDLKFLDLGLVSETVKLKELFSAIKNFTKLTHLSFPRSSIDCQGFQDIEWPQNL ISLKACHQLKYLDLGLVSETVKLQELLAAIQNFKHLTHLSFPRSSIDCEGYREFVWPTNL ISLKSCHDLKFLDLGLVSETVKLKELFSAIKNFTKLTHLSFPRSSIDCQGFQDIQWPQNL ISLKSCHDLKFLDLGLVSETVKLKELFSAIKNFTKLTHLSFPRSSIDCQGFQDIEWPQNL ISLKSCHDLKFLDLGLVSETVKLKELFSAIKNFTKLTHLSFPRSSIDCQGFQDIEWPQNL ISLKSCHDLKFLDLGLVSETVKLKELFSAIKNFTKLTHLSFPRSSIDCQGFQDIEWPQNL ISXXACHNLXYSDLGLVSETVKLTELFHAIQXFTQLTHLAFPRSSVDCEGYHEFQWPPNL ISLRSCSNLRYLDLGLLSETVKLKQLFEAINGFQHLTHLSFPRSSIACEGFREVAWPQSL ------------------------------------------------------------ IALKNCLNLKVLDLRLVSETLNLEELFKSIRNLTELTQLSFPRSSVEIHDYQSINWPPKL ISLKSCRQLKYLDLGLVSETVQLGELLSAINEFPALTHLSFPRSSVDCKGFRDFKWPPNL IALKNCTKLKILDLRLVSETLNLIELFNSINSLDELTHLSFPRSSIEIHDFKSIHWPTRL IALKNCSNLKVLDLRLVSETLNLEELFKSIRNLTELTQLSFPRSSVEIHDYQLINWPPKL IAVKNCLNLKTLDLRLVSETLNLTELFHSMSNLNQLTHLSFPRSSVDIDNYNNIKWPPKL YALKNCENLQVLDLRLVSETLNLEELFKSIRSLKQLTSLSFPRSSVEIHDYEQIKWPPKL MALRSCFSLKVLDLRLVSETLNLEELFQSIRSLDNLTHLSFPRSSLEISNYRSVHWPPKL IALKNCEQLKVLDLRLVSETLNLEELFNSIRNLHNLTHLSFPRSSILINDYKSINWPPKL LALKHCHRLRVLDLRLVSETLNLEELFDSIRHLDELVHLSFPRSSVEITNFENIVWPPRL VSLKSCHNLKYLDLGLVSETVKLKELFSAISNFRELTHLAFPRSSIDCEGFREFVWPPNL VSLRHCKQLRCLDLSLVSEVVDLRLLFLALRQSPELEQLFFPRSSLFCEQYDNV-WPPKL QYLKLSGGITNEFVAMTNWPETITTLEFSFCPQVDEQSIYTVLAKIGHNLKHLSFFYPMP QYLKLSGGITNEFVQETIFPNTIKILEFSFCPQINEHSIYTVLAKIGDNLTQLYFHYPMP RYLKLSGGITNEFVIETKWPRTITTLEFSYCPQITELSIFSLLSQIGDNLKHLFFYYPMP KYLKLSGGITNEFVCETEWPKTIKTLEFSYCPQVDEHAIYIVLSKIGDNLTHLYFHYPMP RYLKLSGGITNEFVIDTKWPTTITTLEFSYCPQITELSIYSLLSQIGDNLKHLFFHYPMP RYLKLSGGITNEFVIDTKWPKTITTLELSYCPQIMELSIYSLLSQIGDNLKHLFFHYPMP RYLKLSGGITNEFVIDTKWPKTITTLEFSYCPQIMELSIYSLLSQIGDNLKHLFFHYPMP RYLKLSGGITNEFVIDTKWPKTITTLEFSYCPQITELSIYSLLSQIGDNLKHLFFHYPMP QYLXLSGGITNEFLGGTHWPKSITTLGFSSCPA--------------------------- VYLKLSGGITNEFIREAALPHTIRTLEFSFCPQVDEHSIYMLLSKTGESLEYLRFYYPMP ------------------------------------------------------------ TFLRLSGGISDDFLYQLEFPPSITQLEFAHCPSISDLGFRQILYRIGANLKTLKVQYPMP QYLKLSGGISNEFVRETVFPTSIKNLEFAFCPQIDEHSVYTVLAKIGDRLTHLRIYYPMP SFLRLSGGITDDFLMQSEFPSTITQLELAHCPAIKDFGLHSLLFSFGKNLTSLKIQYPMP TFLRLSGGISDDFLYQFEFPPLITQLEFAHCPSISDLGFRQILYRIGANLKTLKVQYPMP TFLRLSGGINDEFLSHSNLPELITSLEFAHCPLITDIGIRQVLCKMGQKLRNFKVQYPMP TFLRLSGGISDDFLYELEFPESITCLEFAHCPAISDIGFRQVLFRIGRNLKTLKVQYPMP QFLRVSGGISDDFLIESDFPSTIEHIEFAHCPKVMHVGFQHFLFKMGHNLKSLKVQFPMP SYLRISGGISDDFLRDSHFPLTINQIEFAHCPAILDVGLGNLLLRIGRNLKSLRIQYPMP SFLRISGGISDEFFHRARIPSTITQLEFSHCPSITEAGFQFILSQVGENLRSLKVQYPMP QYVKLSGGITNEFVRETIWPRTITTLEFSYCPKVDEHAVYTVLSQIGDNLKHLFFHYPMP WRLGLSGGISDDFIRETRFADTITHLSLRHCPFITVNSFHFLCQYLGPNLKYLEVVYPMP ALRENSLDFIFRYCRNLLSVRLQVDYCSKWLFSEYILTPIPDLPRPLRTIYLDCSGSLGL ALKDNSLDHVFRYCSNLKVLQLMIDYCTRWVFSEYFFTQL-PYPRPLRTLILECSGHLGQ SLTENSLDHVFTYCANLISLQIMVDYCSKWCFSEFMLSKLMEYDRPLKTLYLECSGSLGL ALNEHSLDHVFRYCSNLITIQLMVDYCSKWCFSEYMLTPLL-IPRPLTTIYLQSSGSLGI SLAENSLDHVFTYCANLISLQLMVDYCSKWCFSEFMLSKLVEYDRPLKTLYLECSGSLGL SLTENSLDHIFTYCANLISLQIMVDYCSKWCFSEFMLSKLVEYDRPLKTLYLECSGSLGL SLTENSLDHVFTYCANLISLQIMVDYCSKWCFSEFMLSKLVEYDRPLKTLYLECSGSLGL SLTENSLDHVFTYCANLISLQLMVDYCSKWCFSEFMLSKLVEYDRPLKTLYLECSGSLGL -----------------------------WMSKDSIVF---------------------- ALGDKSLDYVFRYCSNLLGVQLVVDYCSKWAFSEHLLSPLA-YPRPLRSIVLESSGSLGL ------------------------------------------------------------ GLKKNSLDQVFVYCPNLRVLEISVDYVSSMFFDEQYLGYM-DYPRPLRTLYINSSGMLGT SLHDTTLDVVFRYCTNLITLQMPVDYCSKWAFSEYMLIPLP-DPRPLRVLMLECSGNLGQ GLKDNALDLVFNYCPNLTVLEISVDYVSSAFFDEENLSYL-AYPRPLKTLYIESSGMLGT GLKKNSLDQVFLYCPNLRVLEVSVDYVSSMFFDEQYLGYM-DYPRPLRTLYINSSGMLGT SLKGNSLDDVFVLCPKLRVLEVCVDYLSSTFFDEHNLRHV-NYERPLRTLYINSSGLLGT GLKGDSLDQVFIYCPNLRVLEITVDYVSSMFFDEQYLEYT-DTPRPLRTLYVNSSGMLGT GLQSNSLDIIFTYCPNLLVLEVTVDYMSAEFFDEENLHYL-HYPRPLHTLYLDSSGMLGT GLKTESLDDVFRFCPNLYTLEVAVDYVSTRFFDEENLQYM-DSFRPLRTMYINSSGLLGT KFNEGTLDRVFIFCPNLLVLEISVDYVSSTFFDDDTLVHV-PYKRPLRTLYIDCSGMLGT SLHDNSLDYIFRYCSNLISVQLMVDYCSKWTFSEHMLTKL-IYPRPLKTIYLESSGALGL GLRPDALDQVLRHCPNLRHLSVSVDYLTKHIFDDGMFKRAGHFQHPLEILDIDSSGGLGQ ASKIHPDDFTIALLESRLPSLKNISVSSKLGWDMNGDDVADLLTAFEEQD---G------ TFKVHPDDLTIAICEGRLPCLKIIRISSRLGWDSQGDDVGDLVSSLEEENG--G------ ASKIHPDDLTIAILELRLPCLKTICVSPKLGWNMKSDEVADLVVSLEDQD---G------ GAKIHPDDFTIALWEKRLPCLKSISVSSKLGWNATSDGVEDLVSALEEQD---A------ ASKIHPDDLTIAILESRLPCLKNICVSPKLGWNMKSDEVADLVVSLEDQD---G------ ASKIHPDDLTIAILESRLPCLKNICVSPKLGWNMKSDEVADLVVSLEDQD---G------ ASKIHPDDLTIAILESRLPCLKNICVSPKLGWNMKSDEVTDLVVSLEDQD---G------ ASKIHPDDLTIAILESRLPCLKNICVSPKLGWNMKSDEVADLVVSLEDQD---G------ -------------------CLKLVKX---------------------------------- SFKIHPDDITIAVAEDRLPCIRDVRISSRLGWDSHSSDVEDLVSVLDDRD---A------ ------------------------------------------------------------ STRLDPIDLAVALNDGRLPHLKHIQCTAKLGWDPSSDALGYIADELDERK---G------ AFKVHPDDITIALAEGRLPKLRKLRISSKLGWDSKGSDVNDLISCLEDQD---A------ STKLDPIDLAIAINEDRLPFLKNIRCTAKLGWDPKSEYVTFIVDALDERG---G------ LTRLDPIDLAVALNDGRLPYLKHIQCTAKLGWDPLSDALGYIADELDERK---G------ LNRLGPADLAMALEDGRLPYVKNIQCTAKLSWDPKSDAVISIADELDERG---G------ SSRLDPIDLAVALNDGRLPNLKHMQCTAKLGWNPDSDAVGYIADELDERK---G------ TDKMDPLDLAVALSDGRLPKLKNMRCTAKLGWDPKSDGVSYIADELDERK---G------ STKLDPIDLAVAINEDRLPFLKNLQVTAKLGWDPKSEYVTYIADELDERN---G------ STRLEPIDLAIALNEDRLPMLKNIRCTAKLGWDPQSEYVSYIVDELDDRG---G------ ASKIHPDDFTIAIMESRLPCLKNISISSKLGWDMQSSDVEDLVCAFEDQG---G------ AHKLRADDITLAILEDKIPKLRVVRVSSKMSWDAKDEAVSELASILDDTDANGG------ SLYVSY-VGKSSQIVRYKRTKGLSPLTQRVVTQLSVLSAARKQPKLLKLSKEDLVKHQTI SMYITY-SAASLNFVRGKRTKGLNPQAQRIITQLSVMSASRKQPKLLKLSREDLIKHDMI SLYLNY-FKKPTVFVRNKRTKAMSPLAQRVVTQLSVISASRKQPKLLKLSREDLVKHQTI SLYVSY-MNVFLTSVRTKRTTGVSPQVQRVTTQLSVLSARKKQPKMLKLCPEDLIKHQTI SLYLNY-FKKPTVFIRNKRTKSLSPLAQRVVTQLSVMSASRKQPKLLKLAREDLIKHQTI SLYLNY------------------------------------------------------ SLYLNY-----TVFVRNKRTKSLSPLAQRVVTQLSVMSASRKQPKLLKLAREDLIKHQTI SLYLNY-LKKPTVFIRNKRTKSLSPLAQRVVTQLSVMSASRKQPKLLKLAREDLIKHQTI -------AASILTFTRGKRTKTLPPLVQRAITQSSVLSASRKQPKSSKLSREDFIKHQTI NLYVKF-VPRPRAFVRGKRTKGLSPAAQRAATQLAVMTARKKQPRLLRLSPEDLVRHQTI -----------VTFTRGKRTKSLNPLAQRVVTQLSVLSASRKQPKLLKLSREDLVKHQVI GIYIGY-LNKPKHFVRGKRQAELNIATQKIVNQLSVLSASRKQPKLLKLCNEDFIKHKTI DFYLSYFWKNNLQFVRGKRTKSLSPAVQRVITQLSVMSAGRKQPKMLKLSREDLIKHQTI GLYIGY-KNISKTFIRGKKKTSLSPSTQKVVNQLSALSASRKQPKLINLCNEDLIKHQTI GIYIGY-LNKPKHFVRGKRQAELNIATQKIVNQLSVLSASRKQPKLLKLCNEDFIKHKTI GLYIGY-VRHSSSSSSSSQEKTLNLSTQKIVNQLSALSASRKQPRLLKLCNEDFIKHKTI GLYIGY-LNKSKIFTRGKRVTTLNVATQKIVNQLSVLSASRKQPKLLRLCKEDIIKHKTI GLYIGY-MFSPKVFIRGKKKSVVNPSTQKVVNQLSALSASRKQPKLLKLCPEDLIKHKTI GLYIGY-FTTPKNFVRGKRQS-QSASTKKVVNQLSALSASRKQPKLLNLCNEDLIKHKTI GLYIGY-FNPVAVFVRGKRTGPVSPSTQKVVNQLSALSASRKQPRLLKLCDEDLIKHKTI GLYLNY-QNSVIIFTRGKRTKGLSATEQRVITQLSVMSASRKQPKLLKLCREDLIKHQTI GMWII--THKTQLALRTKRTKDLDPGARKLVNQMSAMSPKRMAPKKLELSQEDLIRHRIV ERSWKLYQQQKTTRQLAQLKQQYLAMEEAMETLKSVSPELYEEANISEEGKQFPLDIKIT QACWAQYQRELREKRTNLLKLQYENIEEAMNLLEQVDPELYEMANAEESGKRVPLELRVP EKCWSIYQQQQRERRNTQLELQYKSMQGAMALLQELSPRLFEAANAPEKGKRFPMEMKVP ENCWIQYQRDVRNRRSKTLEKQFKSIKTAMNTLQEVNPVLFKLASEATTERRFPLEYRIP EKCWSIYQQQQRERRNLQLELQYKSIERSMNLLQELSPRLFEAANASEKGKRFPMEMKVP ------------------------------------------------------------ EKCWSIYQQQQRERRNSQLELQYKSIQNAMTLLEELSPRLFEVANASEKGKRFPMEMKVP EKCWSIYQQQQRERRNLQLELQYKSIESSMNLLQELSPRLFEAANAPEKGKRFPMEMKVP QHCWSIYQKELREKRNEQLKLQYKSAKNAMDVLQQLNPKMFEAANAPEDGKRFPMELKVP QACWNDYQKTAREARSAQLREQYASVAAAMAELERLDAGLFRAASAPESGKRFPLELRVP QNCWSMYQKELREKRNEQLKLQYKSTANAMSLLEQIDAELFAEANKKEEGKRFPLELRVP MNAWKLLQRRRITQQSEKLSKQYKSIVNAMEDLKQTSPELFEAANAKNPKRTFPIEMRVP QNCWSLYQKELREKRNEKLRLQYKSAAKAMDLLQELDPELFEAANASEAGKRFPLELKVP TNAWKVYQRKKSQKKTEQLKQQYESIYTAMEDLKTTSPELFEVANTPEPKKRFPLEMRTP MNAWKLVQRRRITEQSKKLSKQYKSIVNAMEDLKQTSPELFEVANAKNSKRTFPIEMRVP MNAWKLYKQKKDQKRETQLLLQYKSIYNAMEDLKATSPELFEAAGGEGPKNKFPIEMRIP MNAWKLLKRRRVTKQMDQLSKQYNSIQNAMEDLKTTSPQLYQAANAKDNKRTFPIEMRVP TNAWKLFSRKQEEKRVTQLKQQFESIRTAMDELKEISPELYAEANKKEQKR-FPLELRVP VNAWNLFKRKVQQRKHLQLKKQYKSIYNAMEDLKQTSPKLFELANAQQEGKRFPLEMRIP MNAWTLYQRKKQQRQHEQLQKQYNSIQEAMDELKAISPKHYQWANRVEQKR-FPLEMRVP QRSWALYQQDLRNKRELQLKQQYENIKLAMDTLKNTSPELYEIANKSEEGRKFPLEMKIP QVAWREERLAEKLAREQQHRQQYEMLQDTCEELRKVDGFLFNAAVLRVKGNKFPIEMRVP TDAPPNKIWHYNFKK--------------MSNFGRRTWDRDEYDTVPELSHLQSL----K TQYPPNNVWYYDYKK---------------MSFGRRTWNREEYAAKAATSPGGQS---HL TDFPPDTPWHYHFRK--------------MSNFGRRTWDREEYAEQARSGYDEQS---LK TDFPPNKVWCHNYTS--------------MSNFGRRTWDKEEYAIQAQTKSLHES---LK TDFPPNTLWHYNFRK--------------MSNFGRRTWDREEYAEQARSGYDDRS---LK -----------------------------MSNFGRRTWDREEYAEKARSGYDDQS---LK TDFPPNTPWHYHFRKKASQALASTHTRKLMSNFGRRTWDREEYAEKAKSGYDGQS---LK TDFPPNTPWHYHFRK--------------MSNFGRRTWNREEYAEQARSGYDDQS---LK TEFPPNKLWHYTFKKKKSRFIRLNFSTLRMANFGRRTWDREEYAQLAQEEPLSHE-ETLK TDFPPTKLWHYEFKN---MQNKSEDTDATQSNFGRRTWDREEYARLAQEATNHDH----L TEYPPNKVWYYNYKK--------------MSSFGRRTWDRDEYAELAQEGRSHKP--SLL TDYPPNKPWTYNFVP-----MSGESDKISTDQYGRRKWNVDLYEKEAKDRKNQSTTLATT TEYPPNQVWYYNYKA--------------MSNFGRRTWDRDEYAQLEREPKDQAR--KLV SDYPANKPWIYNYSQTMEEDKDNDNNKISIDQYGRKTWNVDAYAKEAKSKSSKKASTPNL TDYPPNKPWTYNYVPMTNESSEKELDKISTDQYGRKKWNVDLYEKEAKDRTNQSTEPSNA TDYPPNKPWIHSFKP------MNGREKSTIDQYGRKKWNIELYAQEARDKKRKRG---ND TDFPPNKPWIYNYAP------MSNNEKITTDQYGRKKWNLEAYAEEAKLKKKPTV---SE TDYPANEPWVYNYSK--------MTEKVSTDQYGRKTWNVDLYAEEAKNKNKRKE----P TDYPPTQPWVYNYSP-------MSEEKISIDQYGRRHWNVEAYAEEAKDRKSKGKRSSHL TDYPADKPWVYNYKK-----MADDNEKVSVDQYGRKKWDIEAYAAESKRRKKNND---KK SDFPAKKIWHYTFRK--------------MSNFGRRTWDREEYARLAREGNDNSEEEKLR TETPPNKIWQSEWKA--------------------------------------------- DTLSDVQLEQLKKKYTNY-DMLLKRSMSGLNKRVLATNVSSF-----------KKGQQ-Y SSLDQEQLKALKDRYTDY-NALLEYNLRDINKKTLSANLSQQ-----------KKGKQ-F NTLTPVELQALKARYTSY-DRLIKGSLKDLNKRKLTANNDGLSSS--------KRGKK-F HTLTASELSELKIRYTNY-DQLMKDSIKGINQKVLTT---GLTSY--------KKGKQ-F ATLTPIELQALKSKYTNY-DHLIKGSLKDLNKRKLTANTESLSSF--------KRGKK-F TTLTPTELQALKSKYINY-DQLIKGSLKDLNKRKLTTNADSLSSF--------KRGKK-F STLTPSELQTLKSKYINY-DHLIKGSLKDLNRRKLTTNTDSLSSS--------KKGKK-F ATLTSTELQALKSKYTNY-DRLIKGSLKDLNKRKLAANTDTLSSF--------KRGKK-F SSLSDAKLQQLKNKYTDH-NRLVRQSMHDLNKKVSAT---GISSY--------KRGKQ-F ANLKEGQLALLKAKYTDH-HKLILEANRDKNKRVLTT---GLTSY--------KKGKQ-F DTLTPQQLAQLKLKYTDH-HRLIESSSRDPNKRMLTAALSSY-----------KKGKQ-F TTTNQINDHSSSSEYIEHRNKLLNESINAVKQYSLINPQTSTSTI--------TFGKNKF DTLTPEQLARLKEKYSNH-DALVKDATKGNHERVLAS---GLSSY--------KKGKQ-F SNSTINADKPLS--YLTHRDKLLNELLSAVNQHTIINPLNTA-----------SYGKNKF TTTNQINDHSSSLEYIEHRNKLLNDLINAVKQYSLINPQTSTSTI--------TFGKNKF DDEVEFKLRDDSQAYVKHRDELLKTSLNAVKTYNLINPDKAELSV---------FGSRKF TIPAQIEDDSSSLEYIKQRNKLLDQSIKAVKKYNLITPELSTTTT--------TYGKNKF SKESILAVEGLKESYNEHRAQLIESSVSAVQKHTLINAEADPTA---------TYGKNKF SGAAVINDEKSSSSYIKHRDTLLKELLGAVKTYNLISPAASATT-----------GRR-F EVAGRIETDKS-ESYLNHRQDVYLQSTRAVNKFTIVNPLA-------------NYGKQKF LSLTDEQLEQLKSMYSDH-DSLLKSGLDDLNKKVLAT---GVTSY--------KKGKQ-F ------------------------------------------------------------ GFYCELCNITLKDSLQYVDHLNHKSHELKFEAL--------------FEEPLITETRD-- GFYCDICDLTFKDTLQFINHLNHKSHVVRFENI--------------FNEPLIKDTRD-- GFYCDICNLTFKDTLQYVDHLNHKLHAIKFENL--------------FDEPLILDIRD-- GFYCEICDLTFKDSLQFIDHLNHKTHEIKFELT--------------FDEPLVLDTRD-- GFYCDICNLTFKDTLQYIDHLNHKVHAIKFENL--------------FDEPLIIDIRD-- GFYCDVCNLTFKDTLQYIDHLNHKLHAIKFENL--------------FDEPLIMDLRD-- GFYCDICNLTFKDTLQYIDHLNHKLHAIKFETL--------------FDEPLIIDTRD-- GFYCDICNLTFKDTLQYIDHLNHKVHAIKFENL--------------FDEPLIIDIRD-- GFYCELCDLTHKDTAQYIDHLNHKTHQLKFEAI--------------FGEDLVADKRD-- GFYCDICDMTFKDTLQYIDHLNHIIHQIKFEQV--------------FGESLVADTRD-- GFYCDLCDLTFKDTLQYIDHLNHKSHQIKFEQL--------------FEEPLIYDTRD-- GFFCPICDVSFRDNLLLIDHLNSPQHVSKTRQMIDNNSAEQELLENGIRRASLQEVVSTM GFYCDLCDLTFKDTLQFVDHLNHKIHEIRFERI--------------FEEPLIQDLRD-- GFFCLVCDLSFRDNLALIDHINSPLHVQRSQSLTKHDGEDTEILDGNVRRATVDEVRLTL GFFCPICDVSFRDNLLLIDHLNSPQHVSKARQMDAENSTEEVFLENGIRRASLKEVILTM GFFCPICDLSFRDNLALIDHFNSPQHLKQAGENSAILKLRQEMLDSGVRRATLNEVVATM GFFCPICDVSFRDNLLLIDHLNSPQHISKLNQVKGDTAQNQELLEGGIRRASLQEVVSTM GFFCPICDLSFRDTLALVDHINSPQHSKRAKALSASGASDENEDIGGVKRASAQEVAEKI GFFCPVCTLSFRDNLALIDHFNSPQHVAKANAIEGVEQEEESVLEGGIRRATLNEVIATL GFLCPICDLSYRDNLGLINHLNSPQHLNKVKAETKFEGDEERPEIDGVKRATVEEVRATI GFYCKLCNMTFKDNLQYIDHLNHKIHQIKFEAI--------------FDEPLILDIRD-- ------------------------------------------------------------ ---------NDDIPIEEFNLLYKEKIRSFVKANRVDTSRRKKKRNNKTNISNN------D ---------NDLVPLNEVRSQFHKSVSAFIGDTELRSNKRKAAKRVKCEKSDAEI----K ---------NDDVPQEEFEKRYNDLVKEFIEVHSTTSQSKKRMSSNTDVNKSKKVNKTPP ---------NDDIEIDEFSNSLKENVKAFVKIHKAKPKRDKDASVKKQRKKNKI-----I ---------NDDVPQEEFELCYHNLIKDFVEVRSMETQSKRKRLLDTDVEKAKKVATKPS ---------NDDVPQEEFEQSYHELVKKFTEVHSTKTQSRKKKFSDVNVNKQPKKVTIQP ---------NDEVPQEEFEQCYYDLVKRFTDMRSTETRSKRKSFLRADVGKSKKAVRRPP ---------NDDVPQEEFELCYHNLVKEFIEVNSTEIQSKRKRFLNAGMDKSKKMVTKPS ---------NDDIPPEEFSKEYKTLVSRFVKQHAS---KPKATSTGTRIGKSQNVNA--P ---------NEHLDAGELAGEYKAQIAAFVRDNSTRSANEKPKRTNRVVAK--------D ---------NDEVSLEEFEQVYSDLIDGFVKTNTTRLKETRKKRIEDPKIRSENKKEKLT ERLIAKSINKSNSEDGRTGLTFNQRVEKRREYEDRKRSKRAERKQIQKQRKKQKTTSDDE ---------NDIVPFNEYEENYSKTIGEFVKQQVPPKKIKNNTKNNVKKEKAND-----A ESLITKL--TQDKNSGNNKTNIKERIARRQEFEKNQQAKRKEKRLKSKQNKIAQKNK--T EKLVAKSISKGNSEDGATGLTFKQRVEKRREYENRKRSKRAERKQVQRQRKKHKKSD--D EKLIQQSVVSKDVPNKA---PFAERVKRRREFEEKKRILRKHQRRERLQREEELARVNCS ERLVAKSIRKNSLENDQSGLSFQERVEKRRQFEEKKKQKRNNRKNVQKQRKKQKLEHD-S EELVKKS--IRDRSSDRNLGSIQERIQKRQEFEENKLRKRREKKLRKRANKVEIS----D ESLVQKH--IKNRNSTPETIQFSDRVKKRQEFEEKMLETRRRKRAKMKLKSQKAE----N EKLV-----QQQLAADEPQQTLEDRIEKRRQFEEKQVKKRRDKRRERKRKK--------S ---------NDEIGIEEFATTYKRLIKGFIKDNGIKQKVNKKSKPIKKVKLG-------N ------------------------------------------------------------ NNDDDTIKKVMGFSNFE-----------------------------------MASHMLTN YQPQSEIGRLMGFTEFGSSKK-------------------------------------MV TENESKISQMMGFSSFGSSM---MDLRDAEP--TVRPNVFSIAKLLD---CKNERPKIAC TNTNSEIHSMMGFTEFGNSKS--MLATQVDK-SDLRESSTKFVHQMD----QVEQLPIIG IESESKVSQMMGFSNFATSKK--MNSGGEEP--TIKPNVFNITQLLN---SNGEKPGIAC IKNESNINQMMGFANFGTSKK--MNFRDERP--TTSPNAFNISRLLD---SNRERPGIAC IENESKVSQMMGFANFTTSKK--MNLRGEEP--TINPNAFSISRLLN---SNHEKPGIAC IENESKISQMMGFANFATSKK--MNSEDEEP--TIKPKVFNISKLLN---SNREKPGIAC SNPPSAIHQSMGFLPLVVQKC--------------------------------------- ETGESDVERLLGFKSFGSSKR-MSLRKQEAP---LSPMVYHPRSGNFQLGSASHRVPLTA QPADDSISGIMGFASFGSTRR---MERAPEP--LDMQYLQSQDFKIP---EPPHKVPISA KETNININNLMGFNSFGSTKL--------------------------------MSSNIIA EANPSDISALLGFGTFASTKR-MYTERKSHMFTRALQLRYDSKPQNFEIAAPSHKVPISC DEGNNDIASMMGFGDFGSTKK----MAASEP-----LSKFNSITSDN---FEYKPSRVTA TETNAKINDLMGFNSFGSTKL--------------------------------MCTNIIA TTADTEMNQMMGFSTFGSTKR------------------------------MTAHSEIAS SSANDDINKLMGFGSFGTTKS-----------------------------MSYQSSTIIG EVGNSELQNAMGFQGFGTTKV-----------------------------MPASPPTPAA QQEESNMAAMMGFSDFGSGKK------------------FFTLSMQT---VSYTPSRVIA VSEDDEISATMGFGKFG-------------------------MTRNL---HEYKSPKVVA SSEDAELHKKMGFSSFGGGV-----------------MDYNDVSSRFDFMKSTTRFPISC ----------------------------------------------------------MQ VFLCQFDMSRGNTLVWSA--RDNDPLLKG-IEFKALPSGIHEVSDDVIRFCIEY------ IFVHEFDVLKGNTLVWTN---GDAKTLEG-LEYTVLPSGIHLRNTDTVYFKLDG------ IFLSQFDMKKGNIIIWSKNIKDTTFNLNN-IEFKSLPAGIHEQTDDIVNFVVPKEEGSGN IFLTQFDVKKGNTLVWSQNDTNEQAIFKN-IEFKTLPSGIHERMDDHVFFTIPK-ENENN IFLSKFDMKKGNIIIWSKSINGAAIDLSN-IEFKSLPAGIHEQTDDVVNFVVPKELDVCQ IFLSKFDMKRGNIVIWSKSINDATFDLTN-IEFKSLPAGIHEQTDDIVNFVVPRGSGAGD IFLSKFDVKKGNIIIWSKSINDATFDLNN-IEFKSLPAGIHEQTDDVVNFVVPKTFGAND IFLSQFDMKKGNIIIWSKSVNDAAFDLSN-IEFKSLPAGIHEQTDDVVNFVVPKALDASH ------------------------------------------------------------ MCLTKFDVKKGNTVLWTT-SLAPEHKLHN-IEFKTLPAGIHESEQDWVNFVLPK-----E MFLCQFDVKRGNIIVWSKTCNNSEISLKN-IEFKCLPSGSHESTEDIINFVLPK------ LFIAEFDVRSGYKLVHQE-AKIAGFDFDG-LEYKVLPSGIQEFGTSTVLFSHWF------ MFLCQFDVRKGNTQVWSKSPDAPDISLEN-VEFKSIPSGIHEFEKDLISFVIPK-----G LFLIHFDVRRGYQLVWSKAKSRPPIDLGG-LDYKVLPSGIQEHTTSTVFISHAC------ VFLAEFDIRSGYKLVWSK-AEVPGFEFDG-LEYKVLPSGIHEYGESTVLLSHWH------ VFLTEFDMKSGYKLQWSKDTNSLLLLLDG-IEYKSLPSGIHELEEATVFISHKPENKNGH VFLAEFDVKSGYKLVWSK-SVIPEFDFDG-LDYKAFPSGIHEFNNSTVLISHCF------ AFLVHFDMRQGYRLVWSR----GDLDLSG-IEYKALPSGIHAHTATTVYLTHES------ MFLVQFEVRTGYEIVWSK-SVIDGYDFSG-LDFKVLPSGIHEFDKATVLVSHLH------ TFLVQFDTKTGYKLVWSK--CNPSLSLSG-IEYKALPSGIHECDSSTVFIVHKN------ IFLSQFDMKRGNVIVWSKLNENCNINLQG-TEFKSLPSGVHEVSDDVINFILPK------ LFYATFDVKLGHSIL-----KGFGEGLGG-VEYKAIPSSFQQ--DDVVYLSHNG------ --EQTQY-YGICCYLQNAFEVLDNEGQVDRSKVKMYSLGVIVDPS------QISDDLRGF ------K-PGLAVFKQNTMELEASQHHIDRSKVRMFSFGTIFD--------------HPM NDKKTVYDYGIAYFKQNSFDIIENDNQVDRNKVLMFSLGIVIDVQGLPSNSTKHFYKEIY ENNNDYY-YGVSFFKQNGLDFMGIHQQIDRKQVKMYSIGVIIDPSAM---------FNPF TAKTTTYDYGIAYFKQNSFDIIENDNRIDRSKVQMFSLGVIIDVQNASSDSKKHFYKEIY NAKDAVYDYGIAYFKQNSFDIIENDNQVDRSKVQMFSLGIIIDVQGASSDSNKRFYKETY TAKETVYDYGIAYFKQNSFDIIENDNQVDRSKVQMFSLGVIIDVQDMSSDSKKQFYKEIY TGKRTTYDYGIAYFKQNSFDIIENDKQVDRSKVQMFSLGVIIDVQDVSSDSKKQFYNEIY ------------------------------------------------------------ DG--EFY-YGVALFSQNGLRVEEEQSHVDRSRVEMYSLAVITDPQLDAMAESKYYRWKPN --GSSHYLYGITAFEQNGQDLIKHNTQVDRSKVYMFSLGIVVDPQQKGVSRSKFYDWKPN --QGKVY-YGLSKYYQYIIGDDSR----DRNNVKMFAMGVLCEPK--------PSVWKPN DNLDEVY-YGIAFFQQNGQALSGSGDQIDRSEVQMYSLGIIVDANYQGVSKSKFYDWKPN --DNTVY-YGLGRFRQRIVGADHESSQISRDDVKMYSLGILCEST-------PNPMWKSN --EGRVY-YGMSRYYQYVIGNDST----DRSNVKMFALGILCDPG--------SSVWKPN HKEDITY-YGVICFKQFAITDTKNIT--DRDNLKMYSLGVLCKPS------SKESEWKPN --QDKIY-YGLSKFYQYIIGDDSS----DRSNVKMYALGVLCDSK--------PNPWKPN --KGRLY-YGLARFRQLNGNKS----GTDRSLVKMYAVGILSEPI-----SG--PHWKPA --SDKVY-YGLGTFRQHIVGQNQP---LDRSTVKVYSLGIICDPA-----TKELESWKPN --DDKML-YGLSQYRSVTEGDNESTETVDRSKVKMYSLGILCDPV--------SKSWKPN EESHDHY-YGVAYYRQNGQEIVKKGKQVDRNEVKMYALGILIDPNLKCYPDDEIFSSRHH ------Q-PGVAVVVDRNIGNN-----EGERRNTVFALGVLVDEP--------------- NYEVTN-QYIPELQSLLKDWTNQGSNSSYEQLSTYYHKKI-------------------- DYEQLS-LYEGGMKDALERWWKDQ---DYSVLEEWDEKQN-------------------- HAYDAN-RYASHLKELLSQWMRKNELDNFDLFENFFEKHN-------------------- QISCLG-MYLNPLESLLSNWMADGKENDFTLLEDFLKEYG-------------------- HAYAAN-RYSSYLESLLGQWIRQRDLDKFDIFEKFFDENN-------------------- LAYGAN-RYAGYLKKLLSQWTRQNDLDKFDIFQNFFEKNS-------------------- HAYSAN-RYVSHLKELLSQWINQENLDKFDIFDNFFKENN-------------------- HAYGAN-RYASYLKELLSQWIRQHDLDKFDIFERFFEENN-------------------- ------------------------------------------------------------ MFICAN-EYKEDLAQLMEQWLKSK---SLEVLEHYFSYNK--------------YQPDLG RFTSAN-EYIDDLQALLKHWLRIGNFSDFETFEDYFDSNS-------------------- EFIDNGWEYADAIHQKLVSFVHSGE----------YVGLK-------------------- QFISAT-EYADDLQELLSHWLKKANHADFSLFESYFDSNS-------------------- EFINNGWEYINKLDDGLEKFLNGND----------YDNFT-------------------- EFIRNGWEYVEEVHQKLVKFVHLRE----------YTDFA-------------------- EFIRNGWEYIDGLKKILDDLDTTRKCDGPINLDEFFNQSG-------------------- EFIRNGWEYVDSLNEKLVQFVHSQQ----------YDNFK-------------------- EFASGGWEHVRSLDVSLQAFLKDEK---PEHMEQLWASLK------KDANADIHSENLDT EFISNGWEYIEVLDSTLVHFLQTEQ----------YDNFD------------------IF EYISTGWEHIESLDSTLYTFLRLQS----------WNDYS-------------------- KYISCN-EYVGDLKKLLSDWLQNEKYDDFSTFESFYNTNK------------------KT ------WNYLNILDTTMKAL-EKGD--EVKVLNGLWSLLT-------------------- ---------------------SGSLNYEVDYQTS----MLNHLPYWLNKLGPLIFPLFKS ------------------GDDTSNFDFNGTCLTI----------------GPIVLQLWRC ---------------KDHIAKNSIETVENSPKER--RHLIEYMPYWTRNLGPLIFPLWKA ------------------------GDKPLPIVENAKYGMIDDLPVWVKRFGPSIFTIWKL ---------------QGHMAENSVEVFEHSPKER--RHLVEYLPYWTRKLGPLIFPLWKA ---------------KQHIAGCTVERADDSIEEG--RHLVEYFPYWVRKLGPLIFPLWKA ---------------QGRIAENSVKVFEHSPQER--RHLVEYLSYWTRKLGPLIFPLWRA ---------------QGHMAENSVEVFEHLTKER--RHLVEYLPYWTRKLGPLIFPLWKA ------------------------------------------------------------ SPLLMRKWPGSSTLTGGSYEDYAQGSKDDAETFKPSKSWLYLLPEIIEQLGPSIFTLWKA --LKSESARLSSPVLQRSWQNAGKFIGENVESRK-HRHMLEKLPELVRSLGPLLFSLWKS ------------------------GIPKVVPNVD--NHLLTNLPEMFRSLGPLVFVLYKQ ----VRAESGTSPVLQRSWQNAGKFTSNNTLQEK-HPHMLESLSQWLNFLGPLIFPLWKA ----------IFDEVFDNLTNTHLKVGKPNININ--NHLLSKLPLMFQSLGPLVFSLFKQ ---------------------KLQDIPKVTPNIN--NHLLTNLPEMFRTLGPLVFVLYKQ ------------------TFKKVFEQADYMKAKNNSNHLLFSLPQLFETLGPLVFAIFKQ --------------PIESVLEGMDGLSPTGPNIN--NHLLTKLPEMFRTLGPLVFVLYKQ KTAKRDHETAKDASKDQSSSLGLDGLDTSAHPTD---HPLAQLPAALSLVGPLIFPIFKR NQLYDRILSSEPHLPVSSSSSRFLLNSLVKLTPNVHHHLLTKLPQMFKTVGPFIFALYKQ ------------VFEELHSSLTGSQLSPNPISPKTDHHLLSALPDLLDVLGPLVFVLYKQ IVKADDGSSGSKTIRSSELTDDIEDTPVPIANINNKLLMLEHLPFWIKKIGPLIFPLWKS -------------------------KGPKPMAPE--RHPIYALVPLLTMIGPEFFEIHRQ CLLRERILVISAPGNSFE--YTNSLLYCLATISRNKLNMGN----TGSKGSYIPTLFTVG ALLQERILIL-NKGVEVK--KCNQLCHLLTKMASL------------EGGTYCNAM-TIT SLLQKRILILIPQGESFE--KCNSLAYCIFLISMLSKNLVG----NHIDDEYVEPLFTVS CLLRKRIIIINPAGSSNY--ACNLLCFWISLLQKI-----------AHDNNMIRTLYTVG SLLQSRILILVPQGESFE--LCNSLAYCVFLISMLPKNLIG----NHVSDEYIKPIFTVS SLLQRRILILVPQGESFE--LCNSLVYCVFIISMLSKDLVG----NHVSDEYITPIFTVS SLLQLRILILVPQGESFE--LCNSLAYCIFLISMLSKDLIG----NHMSDDYIKPIFTVS SLLQSRILILVPQGESFE--LCNSLAYCVFLISMLPKTLIG----NHVSDEYIKPLFTVS ------------------------------------------------------------ CLLRQRILVVNEHGQSFE--RTNALTYCLSVLSLIPLQLERK---LAHANMPLQTLYTIG CLLRERVLILNNAGLSFE--KCNALTYCLSILSLVPKVLQNS---MNFKEETLQPLYTVG SLLRKRILIFNPSGVDNLYNISSF-CYLISLLSVVPQEID-----FVETPTYSQPVYQIG CILRQRVLIITGKGVSFE--KSNSLVYCLSILSIMPHAIS-----NETDNNPLQPLYCVG CLLRKKVLIFHQNHSKIDNFLGAF-TYLLSLLSMIPNDIKI----YSDALTYSQPLYNIG SLLRKRILLFNPNGVDNLYNISSF-CYLISLLSVVPQEIDFIS--QTSVPTYSQPVYQIG SLLRKNIMIFEEEGTEFYRNLTSF-SYLFTVLSVIPKDIEL----EHPELRSQQPLFNVG SLLRKNILIFNPNGEDHLFSISSY-CYLLSLLSIIPQDIELIS--KTSAATYSQPVYHIG SLLRQSVLVFGESGSRRDYALASALVYLISLLSVVPSDVRFEPR-DDSHLLFSQPLYSVG SLLRKRIIFFAKNHRHHLLDHSAF-TYLLSLISVIPHDIETVSK-DEKKHSYSQPIYNIG CLLRKRIMLFHHDPVILSNYAGAF-TYLLSLISLISQDTETI---QSNIVSMSQPIYNVG CLLNEKILILNPLGGSFE--LCNSLVYCISLISLIKKNMKA----KDEYDDFISPLFTIG TLLRNRLLIVHDTGITLE--QATS-VYILGLLGASSDTL-----------PELNLQYNVT TYDIEDLEKHGQ---------------------EGFLAVTSDEILLYKEELFDKALILPS MLNADQFKSFEA-----------------------WCATTSDEILIYDTDLFDKLVIWDP TSDISFLESVDE--------------------GRGYVATTSEEILLYRPEIYDIAVKLPS VMDIDHLKQLSDKKI-------------------GFIACSNDEILIEKTELYDYVIKLPT TSDIPFLESFKK--------------------GNGYVATTSEEILLYKPEIYDIVVKLTS TSDIPFLESFKN--------------------GSGYVATTSEEILLYKPEIYDVVVKLPS TSDIPFLESFRK--------------------GSGYVATTGEEILLYKPEIYDIVVKLTS TSDIPFLESFQK--------------------GNGYVATTSEEILLYKPEIYDIVLKLTS ------------------------------------------------------------ IADLDHLTDMVSDAL-HKSDP-------DGPHLPSFIACTSDEILAERGELFDMVVKLSN ITDIDYLTSLVSESM--ATSA-------DNYDIPGFIACTSDEILLFKNELYDKCLKL-- LTDMGGELLKCR----------------------GYIGSTNDDILKDNA-VYDIGVIIDE IMDIDILTHNVSKAL--ATTE-------ESYNVPGYIACTADEILQDHRELYDICLRI-- LNDLESSLLEFP----------------------ATIATTNDDILMYQKNLYDYAVFLPN LTDMAGELIKLK----------------------GYIGSTNDDILKESP-VYDIGV---- LHELSSNTFKLI-------------------DSNGFIGVTSDEILKNHP-IYDVGVEIGH LNDLTGHLMKVK----------------------GYIGSTNDEILKDNP-VYDVGVVIDE LHDLDTGLFGHH---------------------KGYVACTADDILRQQRQLYDLAVVLPA LNDLDSDDLLKT---------------------SGYIASTSDDILMFQRDLYDIGVILDD LHDLSENDSVLK--------------------TPHIITVTSDEILMYQ-DVYDVGVSLPT VNDIDFLNKVIKESG-----N-------SDYQMSSFVACTSDEVLAYRPELYDIMLKLPP VQDSERLAKMNN-----------------------YLAITSDTIMLHRKSDHDVAVQLSN DSLIHEGLELQDN--------------KGHPVKATIHESRIFNKLLETY----------- NGIHLRD--------------------SMKEIKCNEVDFTVFKSL--------------- SSIMEEFPEKDVEIIAA----------SGEHNKATPLDLETYEKVILCE----------- VFFYKSA---EIIIETN----------QGKAIKATQYESNKYEVLVRDC----------- SSTIEESPEKEVEILTA----------SGEQNKATPLDLEVYEKLILGE----------- SSIMREFPEKDVEILTA----------SCEQSKATPLDLETYEKAILGE----------- RSIMEEFPGKDVEIITS----------SGEHNKATPLDLETYEKFILGE----------- NSIMEESLEKEVEIITA----------SGEQNKATPLDLETYEKFILGV----------- ------------------------------------------------------------ YHGVKVYA-------------------HGTEARATPHEWESFQYLSANF----------- ----KDDGKDIPEFVTA----------SDSSVRATPHEWELYRKLVHVY----------- HAKVFDY--------------------AQQPLRATNKDYQKFGLIYSELPRTRDGFTNSS -----DGQDSLPEIQTA----------GGNYIKATPHEFELYEKLLSRS----------- EEYGNSYILKSDTLVNNMKSPLDF---LNHRVKATLKDYHKFKLIYKQL--LTRTRSHTT ------VIDEWARVFDY----------EQRPIKATNKDYDKFVLIYLEL-PRSDGVTNDT PEIKAFLKQPSTKQQKQQKQQKQQREQRNLPIKATIRDYHKFQKIFSQLSGPGPGPDQDQ KASVFRF--------------------PSETLKATNKDYRKFQLIYQDLPAKKINISNHS TSAESCNAYTS----------------KNEPVRATFNDYAKFCRVFRQL----------P SVTVYNHSDIKDMNID-----------DSKRIRATIKDYKKFKLIYKPI-SCSRQDDTHH DNSGHVKICYANGQATNFNA-------PANQLKATRQDLQKFRSAYKRFKKRQLGSNAIA N-FMSNDNDTLPKLVRN----------DGEIIKATPHELEIYEKLMNII----------- DGVQITN--------------------YGFPS---QRDSRRYHVLTHFI-KAVREEGRGP --CDQDITKRDLER--------------------------------------FSRNTETM --TSDDLSTFNYQY------------------------------------------ESSI --LEDDVSTNVKNK--------------------------------------LHKVTEPI --LHGSI--IIPET--------------------------------------YLPVVEPM --LQEDASTNATCR--------------------------------------HHEVTEPI --LRDDISISVKSK--------------------------------------LQKVTEPI --LKEDASTNFKSK--------------------------------------LYGVTEPI --LQEDASTNTKSR--------------------------------------LHGVTEPI ------------------------------------------------------------ --LYREYSEVEMNG--------------------------------------YMKNVESL --LGEELSETRCVT--------------------------------------FSSSIEPL GISADDLSSIRSDV----------------------SKDFSGSVVGDTPSWWKTDATEPV --LGYQLSHEEREK--------------------------------------VSRLVEPT NASTDDLASIKTSN------------SNVSSRGWGFNSQKDETYLEAEPTWWMDSATCPI DISADDLSSIRTDT-----------WKTFDGECVAQ----------DMPEWWKTEATEPV DQDQDEDQEQDPTTTSSTVVPPTLQ----PLRKTYTDLSPSSPKLSNEPSWWRSATVESV NISTDDLNSLRTES-------------------VRNYNELDLRNDIIEPSWWKEEAIEPV EKPGDDVSIRTATS----------------------------QTERLEPTWWLHDATSPM TIFTNNTNISTDDLNSLYTAASVET--SANPDEYDDILADSGSVYVDEPKWWLDYATEPI TFSNEELSSINTST-------------STKSGSRQNWLFYDPHSAEGEPSWWLEFATAPM --MNEKISPSQRSK--------------------------------------LEKLTEPV AFQQLLSQAHHSQP--------------------------------------CPTSAKKP SWLQYILDSMLFLATAGHITARYNETREI-----IQKSLSREEGEPDE------------ IWSKLIIDGLFMLFTGNLYKPWYHLELAP------------------------------- SWLQFLIDGFYLLTTAGYLMAPYHMAKNF-----RPLKLISSSESNDS-E---------- SWLQFIIDSLYWIATAGTIQPPFELNLDA-----TKILQWGSGSLPPE-HPDRK------ SWLQFLIDGFFLLTTAGYLVAPYHLANNF-----KIPRHVSGPEPNNS-E---------- SWLQFLIDGFYLLTTAGYIVAPYHLVKNL-----RIPKHVSRPKAEDS-E---------- SWLQFLIDGLYLLTTAGYLVAPYHLTKNF-----KISKHVSGPEPNDS-E---------- SWLQYLIDGFFLLTTAGYLVAPYHLAKNF-----RILKHVSGPEAHDS-E---------- ------------------------------------------------------------ CWSQYIIDALYWWSTAGYLQPPYHNTSNL-------LANCDRVDEKNE------------ SWSQYLIDGFYWWATAGYIKPSYHENED-----------LDEKEISDE------------ SWTESIWSAFSWFATAGQYGPPRVPDKVD------------------------------- TWSQYFIDGFYWWATAGYMRPSFHEEGEE-----AIADLDRDN----------------- SWREYVWSAFSWFASAGTVGTLENNDDHP-----SRPINNDESSLNDE-DSRRK------ SWTESIWSAFSWFATAG-----QQLEGSP-----QPPPHVQDKVD--------------- SWSESVWSAFSWFASAGQQLSLDQLPQNTCDSSSQIHLLSNENEFGNK-DGMDSS----- SWIESIWSAFSWFATAG-----QQLETSP-----VTNPPIRHVQTEAD------------ SWREYVWSAFAWFASAG---STSREETDN--------MAWETQQETDD-HQYRQQW---- SWRESIWQAFSWFASAG---QVDSDSAAD-----TATSATSLRKTNLD------------ SWREFIWSAFSWFASAG---TVNREDKED---------DISAENDATR------------ SWVQYLIDGFYLCTTAGYLKAAYRNKSTM-----SFTMFYENNDENET-K---------- LWRQFLANNMLWLASAG---EISTIEDEQ-----YLEGLEFDDEDDDS------------ --------------------------------------HYDARGIVQFFNSRSDELLDYI ---------------------------------------IEHPDFVQYFSERTHDIYQRL --------------------------------------IQMAENLIRYFHLRTSNLYNRL --------------------------------------DGELVLLLQYFHFSKIALYNKL --------------------------------------IQIAENLVRYFHRRTSNLYNDL --------------------------------------TQITENLICYFHLRTSNLYNML --------------------------------------IQIAENIVRYFHFRTSKLYNML --------------------------------------IQIAENLVRYFHLRTSNLYNIL ------------------------------------------------------------ --------------------------------------VEIVLGIVEYFHSKITLLYEKL --------------------------------------LDSVLGLVGYFHQRTCIILNRL --------------------------------------LVDLVNIVGYFHKLTKKWFYMI --------------------------------------LEIVISLVGYFHEKTSLLYASL --------------------------------------LIQLVEIVGRFHMLTKKWFYLM --------------------------------------LVDLVNIVGYFHKLTKKWFYII --------------------------------------LEDIIQTIGVFHKLTHKWFNYI --------------------------------------LLDLIHIVGYFHKLTTKWFYII --------------------------------------FRQLAHVVGGFHRLTKKWFYVV --------------------------------------LFELIKTIGYFHKLTKKWFYLV --------------------------------------YQQLIELVSSFHRLTRKWFSMI --------------------------------------LNVVLNLIKYFHFKTVMLLNQV --------------------------------------LTLEVLLVGYFQQITNRLNATV QRTIEDSNN--------------------------------------------------- KAIVELFPTQD------------------------------------------------- RDIIQKNGNIDSEQ---------------------------------------------- ETILDENESLDSDK---------------------------------------------- KDVIQKSENIDSEQ---------------------------------------------- KDLIQKNEDEDSAQ---------------------------------------------- KSVVQESENTDSEQ---------------------------------------------- KDVIQKSENIDSEQ---------------------------------------------- ------------------------------------------------------------ HEIITDPDADASD----------------------------------------------- NHIIETYDTDDD------------------------------------------------ NEAVLEVWDDQASTDDQPLTRRI------------------------------------- KDVAETSSDE-------------------------------------------------- NEIIREELDEQTQAGASTFTQSDSNGPLLMNMDEDSKI---------------------- NEVVLEVLDDQACTDEQPLTERI------------------------------------- DELIHEVHQEEQARFGSEEDQALVETEVVE------------------------------ NEMVLEVLDDQVITEEQPLTERI------------------------------------- EEIVAEAVEEQGEGA--------------------------------------------- NEIITEQLDDLVPQGESLHGHDDEVNTSLLSLLTSSSKI--------------------- NDIVMQELENNGVVYTDGHPLQEKL----------------------------------- QAMIESNECHNSSD---------------------------------------------- QSLVTRDLYRENHH---------------------------------------------- -------------ILPATITIDLDMDYFSKQDYEFLRMFAKKWLD-KDIMFKT---NILG -----------SIYQNANILIDLRLDYFN--DTDFIRQLSQHWFE-KPVIPSYIDLSF-- -----------PITIAASFLTELNLDCFSLQDHQFIKDITYKWFQ-RSVDISNLP-ECVG -----------PVHLTRFTLHELGLDCFSGQDADFIKELSIEWFN-REVSINYF--NFYG -----------PITIAASFLTKLNLDCFSKQDHQFVKDIALKWFQ-RSIDISNLP-ECLG -----------PIIIAASFLTELNLDCFSIQDHQFIKDIVDKWFQ-KSIDISHLP-ECVG -----------PITISASLLTKLNLDCFSKQDHQFIKDITYRWFQ-RKVEISNLP-DCLR -----------PITIAASFLTELNLDCFSKQDHQFVKDITRKWFQ-RSIDISNIP-ECLG ------------------------------------------------------------ -----------RIAVPSLFLAECGLDCFSFQDHEFLKTLCAQWFN-VHIEIRVADFNV-- -----------TVIISPHVLIEIGLDCFSSQDYEFVEKLSFKWFK-KRVIVKQVDVKV-- -----------CLELTYQDVVEMELDPYSNADLEFLKQFVLLYWE--VVDSVEIGMGLNS -----------TLTVSPPFLAAADLDCFSVSDYQFLNVICQKWFM-KSLQVRSLD---CR -----------SIELTYQDIIDMELDPYSEQDLQFVKDFVILYWG-SVVKNVEIGIGLSG -----------SLELTYQDVVEMELDPYSSADLEFIKEFILLYWE--VVDSVDIGMGLNN -----------VLQISYQDMIEMELDPYSVLDIAFLKEFVALYYR-EKVDRVNVGYNFSN -----------TIKLTYQDILEMELDPYSKEDLEFIKEFILLYWE--VVDDVEIGVGFTN -----------TLRLTHQDVVDMELDPYAEQDVRFIEEFVLLYWG-SVVDAVEIGIGFEN -----------RVELTYQDIVDMELDPYSEADLQFVREFVLLYWG-SVVDSVEIGIGFTS -----------SIEVTYQDIYDMELDPYAYSDLQFIHEFVATYWG-EIVGRVQIGTGIGG -----------VIHTSPVSLTEMDLDCFSEQDIDFVEKLISKRFK-RNLVVNNG--DYFR -----------TLTLAHADVLQTGLEMYNSHDEKFLHDYVERWWN-TDINVSYLGL---- I--Y--------MTTLKHKTKKEEETNS----------SAEEYSGAEASSSDVDASGSEE ---LFMSSKGKIPVTKKSKLNDKSAKIRKVKENEVSQLADEVDSDVDSEGSTGSEIDNDE D--LCMGPKNTVKATQKKRTRKDAEDGHQKNKVELKNNLEKKAVSEEEEEASEQDNSDDE M--FYKGSVTVGKKVANKRSRNEEDPVTVTSDDHVSTGGESEEEDDELDLADVSSASEKE N--LCMGSKHRVDTKDKKRTRKNAEFGRNSGNQELSNEPEKDTIMEGDEAEEDEQNSSSD N--LCMSSKYTVKTKQNKRTKKDVEAESGGSNAELKNNLKKKTVSKEDKEEANEQDSSDN N--LCMSSKYIKKANDNKRTKKDVNADEGGNNLNLNINLEKETVSEQDEFEDKEQNSSSD N--LCMGSKHTVDTKNKKRTKKDADVGRGGSSLELNNNLEKESVSAEEEVEQDEQNSSSD ------------------------------------------------------------ ---FCQAVKHVSSTHMTAKVSSTSHASKVLKNVHEHDAVPSTSTPPSEGVAETAASGSEE ---LCLKTNKKSNVEQAELKRKITKNDEPSEDKSAEQNSSEEETGKEESSEEESGSEHEI I--CCMVSVNKEKKKTAKVVIEEEEQDQSSQEVESEDESDSELEVADNDDLDQEIGSDDE V--VCMGFIEGTNPRKKQQIRKAAKGGNVAADKTADVGVDGGSNDELEGRSSAEEDQSSE I--CCMGAAAKDAKVTKKIEKKNEVITSNESVESSDEDNENLEDIEGDDEVDIEVDDEVD I--CCSASKNKQRKKTVKVVIELEEQEQSSQEAESEDSSASELEEVDNDDLDQEIGSDDE V--CCVKVKKSVAVSKDLSSPSSSEDESGEQIDSEEEEEEEEEEEEEEEEELSELDEDDE I--CCKQKINKKKPKVTIEQEEEESSSEEKEEEEEEEEEESELEEQQDSELDEEIGSDDE I--CCMGAVTKLSKEKTQSTKTENDVSPPVSSSEAEGASSEEIEEASDSDLDDEFDVDNV I--CC---------------------------------------------------MDDD V--FCTGVKGSLPVKAQKPKKDNKKAEKVAQDSPSDDLDDEDDVDEDDSEASGSESEASE A--ACMGLQGKVSVAVKKRQRDDEVVDKSGSDSEGGVSSSGVESGEDDDELDLDGVSSSD -FKCCSGAKGKAKPKQQKVSKQQKAAEEDEDLDDLEGGDGEEDEGVDSEEEEESEDDSED SQGEDNEDEDGDEEEGDDEDFPRKKKAKNKHDDGSAGFSQALNAILGSHLKAYDRKDPIM MDLNEVSSDDASDEDSDDDDFPRKKKSSSKHDDGSSTFSSALTNILSSHLKAYDRKDPIM SSGDEQEDGAEVEE---DDDFPRKKKSKSKHDDGSAGFSTAVNAILSSHLKAYDRKDPIM SDDGSVEGAESAEEEEEDDDFPKKKKSKSKHDDGSADFSSAVTAILSSHLKAYDRKDPIL ESSKIIDNEQSDAEEDDDDDFPRKKKSKSKHDDGSTGFSAAVNAILSSHLKAYDRKDPIM ESSENIENQGSDVEEEEDDDFPRKKKSKSKHDDGSAGFSTAVNAILSSHLKAYDRKDPIM ASADVIENEHSGTEEEGDDDFPRKKKSKSKHDDGSAGFSTAVNAILSSHLKAYDRKDPIM ESSEIIENEQSDTEGEEDDDFPRKKKSKSKHDDGSAGFSTAVNAILSSHLKAYDRKDPIM ------------------------------------------------------------ SAVEESAGSASGTEEESDDDLPAKKRASPKHSDGAEGFSSALTNILSSHLKAYDRSNPIL GDELDLDQVSSEDDESHDDEFPKKKKSKSKHDDGSSGFSTAVNAILSSHLKAYDRKDPIM VNIADASSSEGSDASEDEEDFPKLKKRKKSTEDGSESFADALNSIVNSKLKAYDRKDPIL DGSEEEDNLDSEEDDSEGDEFPLKKKSKSKHDDGSSGFSTAVNAILGSHLKAHDRKDPIM VDGISSDEEAEGDEEEDDDEIPKIKKKK-NLDDGSESFANAFNAIVGSRLKAYNRKDPIL VNIADVSSSEGEDESDDEDNFPKLKKRKKSTEDGSESFADALNSIVNSKLKAYDRKDPIL VDVADVSSGDEDEDEEEDDEFP-LKKKQKNRDDGSESFANAFNSIINSKLKAYDRKEPIL VDLADVSSSSDDDEDEDESNFPKLKKNKKSIDDGSESFATALTSIVNSKLKSYDRKDPIL SSDDENAASSGSESEEDDDKVP--TKRKKASDDGTGTFATAFNAILGSKLKAYDRKDPIL VDVADVSSSEEGKESDDDDSFPKMKKKK-NLDDGSESFATALNAIVGSKLKAYDRKDPIL SESESDAESEAESEAESSDAMPKKK---RKTGDGSQEFANAFNAIIGSKLKAHRRNDPIM GEGEAEGEAEGDDEEDEDDDFPRKKKSKSKHDDGSSGFSSAVNAILSSHLKAYDRKDPIM DSMMEDEFDIDEDESED----SALHKAKAKKDE---AFGKAFSAILGSSIKAHAKENPIL SRNKSVLKQNESQKLELKAKKALLAEKKKLLNKTRKKEVIPDENKSIIEKETRLRKIAQK ARNKKVLKQNEADKLEQKAKRAILTEKKQLLNKTRKKDIIPADANSILEKERKLRKIAQK ARNKKVLKQTESEKLEYKAKKEMLAEKKKLLGKARKRDIIPGEGKSVLEKETTLRKIAQK ARNKKVLKKNESDKLESKARKALATEKKKLLNKTRKKDILPADNENVIEKETKLRKIAQK ARNKKVLKQSESEKLEYKAKKALLAEKKKLLGKARKTDIIPGEDRSVLEKETALRKIAQK ARNKKVLKQSESEKLEYKAKKALLAEKKKLLGKARKRDIIPGEKKSVLENETTLRKIAQK ARNKKALKQSESEKLEYKARKALLAEKKKLLGKARKRDIIPGEDRSVIEKETALRKIAQK ARNKKVLKQSESEKLEYKARKALLAEKKKLLGKARKRDIIPGEDRSVLERETVLKKIAQK ------------------------------------------------------------ ARNKKVLRQNEADKLELKAKKALLAEKKQRLAKTRKRDILPADDDATLEKERRLRKVAQK ARNKKVLKQNESQKLEQKAKRELLAEKKKLLNKARKKDIIPIDTDNVLEKERKLRKIAQK ARNKVTLKKLESDKLEMKAKRALLQEKKVLHDNARVKNLLPTSNEPVIEKEKALKKVAQR ARKKGVVKKLESDKLEQKAKRALLAEKKKLLNKTRKKDIIPAEAESVLEKERRLRKIAQK TKNKTTLKKLESDKLEAKAKRLILSEKKQVHDKNRVKNLLPSASEPIIHNERQLKKVAQK ARNKVTLKKLELDKLEMKAKRALLQEKKVLHDNARIKNLLPSGSEPVIEKEKALKKVAQR ARNKTTLKKLESEKLELKAKKALLAEKKQFKDKHRVKQLLPEGEDPILDKEKQMKKIAQK VRNKTTLKKLESDKLELKAKKALLQEKKNFQDKYRIKNLLPNEQEPLIQKEKDLKKVAQR ARNKSHLKKLESDKLEAKAKRLISAEKKDLRDKQRIKNLLPNADEPALERERAMKKVAQK ARNKVTLKKLESDKLENKAKRALLSEKKQLQDKHRVRNILPSASEPIIQSERQLKKVAQK ARSKNVQKQLDSAKLEAKAKKQLLAEKKALHDSHRVKNLLPSANEPMIEDEKKLKKVAQR ARNKKVLKQNESDKLEQKAKKQIANEKKKILAKARKTDIIPEGQSGILEKEARLRKIAQK IRSTKSAKELEDQKLEAKARRLIKLEKRKAAEKDRVKTLVP--DEPILANEKKLKKVAQR GAVKLFNAILSTQVKTEKEVSETDINRKEKKQLITEVSKEKFLDMVKAAADDNLTELLSQ GVVKLFNAILSTQVKTEKEINDGGVNRSERKELITEVSKEKFFDLVKTAGDSDLVSLLTK GAVKLFNAILATQVKTEKEVTESGINKEEKRELITEVSKEKFLDLVKAAAGNNLTSLISQ GVVKLFNAILSTQVKTEKEVSTGGVNKQEREQLITEVSKEKFFDLVKAAAEDNLTNLLSQ GAVKLFNAILATQVKTEKEVSESEINKEEKKELITEVSKEKFLDLVKAAAGSNLTNLLSQ GAVKLFNAILATQVKTDKEITESGINKEEKRELITEVSKEKFLDLVKAAAASNLTSLLSQ GAVKLFNAILATQVKTEKEVTESGINKEEKKELITEVSKEKFLDLVKAAAGSSLTNLLSQ GAVKLFNAILATQVKTEKEVTESGINKEEKKELITEVSKEKFLDLVKAATGSNLTNLLSQ ----------------------------------------------------NLTRLSSQ GVVKLFNAILATQVKTEREAREKDVNQAERRELITEVSKEKFLDLVKAAGDADLKSLIER GVVKLFNAILSTQVKTDKEASEGSVNRTERKELITEVSKEKFLDLVKAAGDSSLTSLLSQ GVVRLFNAVLSTQIKTNQEVNKEKLGQTKKEEIMNEVSKNKFLDLIAAAGNESIADAFKK GVVKLFNAILSTQVKTERDGAEADVNRAEKKELLAELSKEKFLDLVKAAGDSDLASLFTD GVVRLFNAVLSTQIKTNEELGQEKVGQTKKEELMNEISKEKFLDLVQAAGQSSIVQAFKS GVVKLFNAVLSTQIKTNQEVSKEKLGQTKKEEIMNEVSKNKFLDLIAAAGNESIADAFKK GVVRLFNAILATQVRTNVEVSKEKVGQAKREELMNDVSKEKFLDLIAAAGEDSIGETFKS GVVKLFNAVLSTQIKTNQELGKEVIGQTKKEELMNDVSKEKFLDLIAAAGNESIADAFKK GVVRLFNAVLATQVKTNQEISKEKVGSSKKEELMTEISKNKFLDLVKAAGQTSVIEAFKG GVVRLFNAVLSTQIRTNQEVSKEKVGQTKKEELMNEISKEKFLDLVQAAGQSSIAEAFKK GVVRLFNAVLSTQIKTTQEVSGEKVGLVRKEELLNEVSKEQFLDLVQAAGHT-------- GAVKLFNAILSTQVKTDHEIKTTDINKQERKEYITEVSKEKFLDLVKAAGDDNLTQLLGQ GAIRMFNAILAAQT-GAKSMDETSIGAKKREEMASQMSKESFLDAVREG---DLTTLIDK LNVQSNNSEHVDAAKTCKELIDNGCKEGEVFRQWLVALIKQDKYQAAFDLIKHLDNRHGS LNVK-DEKVHIDAIQTKYDTLSKTLGEEETSRAILNELLDSEQYSAIIKAHRKSPSAKPN LNIQLSQDEHSQVEQTCVKLLDSGCDPADVFRRCLVAVIQQDKYQRALHYLKKIDEKFGR LNVESTHNEHSKAEQTCLNLLDGGCNPGQIFKHCLIAVIKQDKYERALALLQRIDEKYGS LNIQLSQDEHSQVEQTCVKLLDSGCNPADVFRRCLVAVIQQDKYQKALHYLKKIDDKYGR LNIHLSQDEHSHVEQTCVKLLDSGCEPADVFRRCLVAVIQQDKYQRALHYLKKIDEKFGR LNIQLSQDEHPQVEQTCLKLLDSGCDPADVFRRCLVAVIQQDKYQKALHYLKKIDERFGR LNIQLSQDEHSQVEQTCVKLLDSGCNPADVFRRCLVAIIQQDKYQKALHYLKKIDERYGR LNVHSAQGESSKVQETCVESLENGCEPGSILKNLSVSIIQQDAYQLGLDMLKNIDEKFGS LNLSSSKDEHSQVAAAYLELVANGCDVCGALEKCVTALIKQDRYEQAMEVFAEADVCKEG LNVQSSSSQHSEVEATCFKLLASGCNAVAVLRQCLVALIKQDKYQQCLDTLDKIDEP--K LNVSSSTSEHEKIFNVSYEYLSKVKNDLKASKNCLVALINLDKYYKAEQIIRKLPSSLVN LNVQYNNSRHSEVARTCEKLINGGVNP--ILRQWIIALIKSDQYKQCQSLLKKYEAELSG LNVSHSVSEHETIYDVSYQYLSNIKNDLISFHNCLVALINLDRYYKAFELIKQVPEDVHT LNVSISPSEHEKIFNVSYEYLSKVKNDLKASKNCLVALINLDKYYKADQIIKKLPKSLIS LKLTSSPSEDEQIYKVSYEFLKQKKNDEQAFRNCLVSLINLDKYELADQLIKKIPSSLVE LNVSLSQSEHDKIFNVSYEYLSKVKNDLKAAKNCLVALINLDKYHKADQIIKKLNKSLVG INVAHDLTEHEAIFEVSYQYLSKIKRDLKSFHYCLVSLINSDKYYRALQLIKEVPNEIHQ LNVATDVSDYEHIYSVSYEYLSKVKHDLKAFKNCLVSLIFLDKYHRAFEIIKKVPEGFSN ------------------------------------------------------------ LNVQSSKDEHSKVQETCLNLLENQCNAADVLRHYLVACIKQDNYQKALDVLKKVDESAGD LNVSSAASAHDQAYSFACQAEKYDPKDLNIQRHKLVALIHLEKFDEAEQVLQD-KGT--T EFVLEKLYVYYKLNSVHEFEQVYKTYQMERGILHIRAQFCYKNGINKEAHEIYEHLSESN SFSAYEQYACYKVGKEKKFASDSDVSDSQRQLLHIYAQNLLKKKKPKKAYEVYQKLLAIP KFALEKLYIFYKLNSSDEFNALYRQIESLRGILHVRAQYCYKNGLYQEAFKIYQHLASHN QFMLEKLYIYYKLNQVAKFEKLFSSKSKNRGLLHARAQFCYRNGKYEESYKIYHYLASSN KFALEKLYIFYKLNMPDEFNTLYTAIESLRGILHVRAQYCYKNGLYQEAFKIYQHLASHN RFALEKLYVYYKLNRSEEFNTLYKKVESLRGILHVRAQYCYKNGLYEEAFKIYQHLASHN RFALEKLYIFYKLNKPDEFNTLYKDVESLRGILHVRAQYCYKNGLYQEAFKIYQHLASHN KFALEKLYIFYKLNKPDEFNTLYNEVGSLRGILHVRAQYCYKNGLYQEAFKIYQHLASHN EFALEKLYIFYKLNKLKEFQELYSVLAPLRGVLHVRAQFCYKNGFYDEAFKIYHYLATHN RFALLKLYTFYKLGQSAAFETEWAQVAELRPLLHVRAQFDYKMGRYSDMFRTYKYLAAHN RFVLEKLYAFYKLNKASDFEKLYSTVESVRGFLHVKAQFCLKTGQYEEAVQIYQYLSSHN SLILEVAYVYYKIGKVEELVKLYEATAVDIGLKHVLAQSYYKIGSYEKALELYKELIKNN VFYLEKLYVLYKLGHVKQFESLYQESSSDRGLLHVRAQFCFKNGKFEEASRIYQVLATHN EFVLEKAYIYYKTGNSKLLLDIYNNDILSRALNHIVAQDYYRNGNSAKALELYVQLIQSN LLLLEVAYIYYKIGKVEDLVKLYEANGADIGLKHVLAQSYYKIGKYEKALELYNELIKNN PLILEIAYVYYKIGRALEIYKLHEEYAVARGFAHILIQTYYKAGEFSKALELNRKIAGDV PLILEISYIYYKIGKIDELIKLYESNGASIGLKHVLAQSYYKIGDYEKALELHQQLISNN EYPLEKAYVYYKTGKVDLLKDVYKSTALSRGLKHVVAQSYYQTGKYDAALQLYSELISTN SLVLEVGYVYYKLGKSAEFEQLLKSVGIAIGLKHIAAQNYYKLGDYGKSLQLYKELIESN ------------------------------------------------------------ SLILEKLYIYYKLNLKNQFERLFEGSERLRGILHVRAQFCYKNGKYDESFKIYQLLATKN GLEFEAAYIYYRQGKHAELAKVLETAQKDTRLIHIAAQAAYKEEDFDRAYELTQELLGTG KDDDNSELICNILVPLTADPKLSANLKHESEKSYDVLFNYSIILVALKEYELAFKVLDKA HEDNTAELACNKEAALSEIPELVLDK---EFDTYDISFNKACQLCSIRNHEAALEYAERA DRDSQIELACNERVPLSVAPELMSPLVTTDESSYDLLFNESFILTSLGKYDESIEILEKA DQDNDLELACNERVPLTALPNLESPLFSKHDESYDLLFNESMILSAKECYQEAIELLTRA EKDSQIELSCNERVPLSVATELMSPLVTPDESSYDLLFNESFIMASVGKYDKAIELLEKA EKDSQIELACNERVPLSAATELISSLVTPDGSSYDLLFNESFILTSLGKYNEAIELLEKA GKDSKIELACNERVPLSVATELMSPLVTPDESSYDLLFNESFIMTSLGKYNEAIELLEKA ETDNQIELACNERVPLSVATDLMSPLVTPDESSYDLLFNESFIMASIGKYDEAIELLEKA EKDDELESACNVRAPLTVTPELRLPLAPESSSSYDLMFNDSMIQCSLGLYDESLELLTKL EEDDGMELACNERVPLAFLPAEAAEVSGKVEDSYDMLLNESMVCSSKGQLEQAESLLKRA SHDNELELSCNERVPFSSLPNTN-KLVTQNEESYDLLFNESMILTAKGCYDDSLGLLTKA QYDDELDLVINEKAIVSQLNFQKESSTTTNANNYDLLFNEALIKLSTLNTTQTLALLDKA EQDNETELACNERAAVSSTPSSIKELVTKNEDSYDLLFNESLIALARNDADLSLNLLNKA KEDNSLDLSCNERAIIHQQNLMDLSLTNSIEESYDLLFNDSLVHLSRGEYATALVLLDKA KYDDELDLVINEKAIVSQLNFQKESTTTGNDNNYDLLFNEALIKLSILNTTQALALLDKA FAEEHGDLVTNESAIVSQLIFQSEQPMDADETNYDLLFNEALIELAKANLSKSLTLLQKA KYDDELDLMINERAIISQLNFQTVNFSKKEENSYDLLFNEALIELSKQNTFKALDLLEKA TVDGTVDLACNERAILSQIAMKSVPQSTVSTETYDIIFNNALIKLASGNYDESLQLLKSA KYDNKLDLIINERSVISQLNFN-KNKVESYGENYDLFFNEALIELSNNNFHKSIELLEKA ------------------------------------------------------------ NSDNVTELACNERVPLTAYPDLISQLITKNDNSYDLLFNESIILSSNGDYTSSISLLKKA --IDELDLLVNESAIVAQQALHRPLTMTSAKSSHDFLFNRAIAELSEGRYDSALDLLSQA HELAVPEGYQNDLDTIELQKSYLLQITGQTVQSKEILKPLLDRLVPGSPLQLIANSNYHA FNLAQEDDAAEDLRAIKLQISYIHQVLGHKEEAKSLLKEIENSADQNDLNTVLAKANLKS LQAATDEGYQNDINTINLQLSFVLQMKGETTKSKEILKSLLKELEASSPFYLICQNNLNA LTMAKGDGYESDINAIELQLAYVYQMMGEKDDSKKLLNNLLTKLEPGSAFQLIVKNNINS LQGATNEGYQNDINTIKLQLSFVLQMVGKTAQSKEILKGLLQELKADSPFSLICQNNLNA LQAATSEGYQNDINTIRLQLSFVLQMMGETRKSKEILKSLLKELEATSPFYLICQNNLNS LQEAINEGYQNDINTIKLQFSFVLQMMGKTAKSKEILKSLLKELKTDSPFYLICQNNLNA LQEATNEGYQNDINTIKLQLSFVLQMVGKTTKSKEILKSLLKELKADSPFYLICQNNLNA TN---------------------------------------------------------- LELARAEEVEDDVHTIQLQLAYVTQLLGRKKESRKLLTDLQKQVSAVSPLVSIIKTNLKS RSLAIDEGFEEDIKAISLQIAYVNQLMGNNAVSKDILKKLVENLPPGSPMYLLAVNNLKS SQVVSGEDLVSELLPIKLTTAYVYQLTGESNKSLEILESIDVEKINDLLIKLIVKNNLYS SSLAKQEGTKDDRQTIQLQTAYVLQVLGQRKEAKEILQILLNESEAGSRFYLLALSNLKS EQKCLHEDVLLELAPIKLTTAYILQITNKTDEALKILKELELEPINDLIVKLILSNNHYS SQVCSGPDLESELLPIKLTTAYVYQLTGESKKSLEILESIDIEKINDLLIKLIVKNNFYS HQVCDEEEAEVELLPIKLTISYVQQLSGNTEEAEKILLLMNTDQVHDSLLKLIVNTNLHS ANLCSGSDLESELLPIKLTIAYVYQLTNDQSKSLDILENVDVEKINDLMIKLIVKNNLYS LSQCEPTELMMEVSPIKLTVAYIYQLSGRIDEAVEVLSTLDLTFITDLMVQLIIKNNYKS ESVCSKEDLLVELLPIKITSAYIYEILGQSDKSLEILHESNADTINDAMIKLIIKNNIFS ------------------------------------------------------------ LDMAKKEDYQLDIDTIELQLAYVHQLNYNKSEAKSILKSLLERLDKKSPLSLIAKMNLLS QVACSEADMPEEIDTVKIQAAYIHQLKGDTAEAKRILDSVESGSHLSGLTDLVAANNAVT FVDYSNFDLLLRQINQRFYSYHLQKYTHEQWKLINNNLLFLNLFNNNQINRKETILAKTL YVSISNLPLLLRELDTPTLTGKHSQFSFQQAQIISSNIELLKVFSNAGKTSVHSIANKF- FVDLSNFNLLLRELNARLNTFNLQTFTYEQWSNIQRNILFLRLFNNGKIRSQDSILSKTA FIDFSNFNLLQRNLNFKLNSLNLQNLTFEQWSTIQRNYMFLQLFNNNKVQSKSTILSRTL FVDFSNFNLLLRELNVKLNTFNLQTFTHEQWSNIQRNVLFLRLFNNVKIHSQESLLSRTF LVDFSNFNLLLREINVRSNTFNLQTFTYEQWSNIQRNILFLRLFNNVKIHSQDSILSKTA FSDFSNFNLLLRELNVRLNTFNLQSFTHEQWSNIQRNILFLRLFSNVKIHSGDSILSKTA FVDFSNFNLLLRELNVRLNSFNLQTFTCEQWSNIQRNVLFLRLFNNI--HSQNSILSRTF ------------------------------------------------------------ LDDLSNLPLVLRELDARLASSSSKTYSHDQWLRLQANLLFMRLFSN-TIRSKSTILSRTL FFDLSNFSLLLRELNAKLNSLNVSKFTHDQWCLLQSNIAFLQLFNNSSIQSKHTVLSRTL HSTITNINLVDRDLNYQNLHKLSQKLTVLQYERVLKNSLVLKFASGSKSQLNNQFINNFQ FQDISNIPLLLRELNVSKLTGALGSLGLEQQETILNNILFLNLFNNSSIQAKSSLLSRTL ITGKSNVNFMHRELNYYNLHHLQQKLTKPQYHVLIKNHLLLSFFSGSNKYLNSKSIDQWL HSTITNINLVDRDLNYQNLHKLNQKLTVLQYERVLKNSLVLKFASGSKSQLNNQFINNFQ FEKDANPNLTERQLNLERLQQLKQKLTIFQCETILQNSMLLRYATG---TLNNSLLLKSS YKDLNNANAIERDLNYQSLHKLSQKLTVLQYETILKNSMMLKFLTGSQSQLNNQLINEFN LHPSENVNFVARELDYFHFHHLRQKLTPIQRHTLLKNHLLLSYQSKSKSYLTNRFYKEYS LAKEPDYNLIDRELNYTNLHKLSQKLTKFQYQVIFKNNVLLRYATGSKSQVSDSFIAKYI ------------------------------------------------------------ FNDFSNLNLLLRELNYRLVSLDLQNLTNKQWKSIQNNLLFLRLYNNSSIQSKDSVLSRTL LSPDINPNVALRKLDHLGLSSTAKGPTAPNGPAIQAQRKVFALNRLEGSKDTSKLAKKLT YKNLIDNVAIEPYKTQAKKLYHFTMQSIDSNGSAIGNLLLTVQLLVVEKQYDNAIRICEN YTENVGNVLYEPYENQADALCKKLDRSAKAEQKLLIQTLVCVQVLVKAGNLDKALVVAEK YSELVDNVTLESYKTQAKKLYHHVTKSILSEGSVIGLLLLTIQLLIIEKEWENAIRVSEL YSNLVDNVSLETYKTQSKKLYHHCISMINSTGSVIGFLLLTLQLLIVEKQWDNSIRLCES YSKLVDNVTLESYKTQAKKLYHHTTKTILSDGSTIGILLLTIQLLIIEKEWENAIRIGEL YSKLVDNVTLESYKTQAKKLYHHTTKTILSEGSVIGLLLLTIQLLIIEKEWENAIRIGEL YSKLVDNVTLESYKTQAKKLYHHATKTILSEGGTIGILLLTIQLLITEKEWENAIRISEL YSKLVDNVTLESYKTQAKKLYHHTTKTILSDGSAIGILLLTIQLLIIEKEWENAIRISEL ------------------------------------------------------------ YSKLVDNVCLESYTVQAKTLFDHVLSLAKKDENAVGVLVLAVQLQLKAKNIGRAILLCEK YQKLVDNVVLEPYKTQAKKLYHHVIKRMKGQGSVIGILLLAVQLQVLEKQIDKAIELCEL FPGSTLNIDHKDLQDLGRKLVKYIPTQTDNDLKIV-ATLILVSVNAQIGSFDQSLPILEQ YQKVVKDVVLEPYSTQAKKMFHHTMSAISCEGSVIGSLVLTVQLQVLEKEWDRAVKVCEA FPGTQLSIDINDLSNSCKKLFKFVSNNVDQ----IAATLLLVFINSKQNRFDQSMIALEK FPGSELNIDYKDLQDSGRKLVKYISTQTNNDDLKIVAILILVSVNAQIGLFDQSLPILEQ QPYISNGISFESLSDHGKKLVRFIKQEEEKKNTDVAATILLVFVNSQLNNFDQSLPLLEK FCGLKLDIDYKDLQDSGRKLVKFISTSSDEQLKVV-ATVLLTFVNSKSGSFDQSLPILEK FNGITLDITLEDLESPAKKIFKFARGKLESISDILAAAILLVSVNTVSGNYDQSLLILEK FPGLSLDINFKDLNDESRKLYKYVKANYNDSNNLIIAVLLLVFVNDKAGNFDQSLTLLEE ------------------------------------------------------------ YQKVVNDSVNETYESQAKKLYHNVITSMQSEGNLIGQLLLSLQLQIVVKNWDNAIRLCEL YPGSAQVVAATNGNSDLEDLIETLRKR---DPKCIGSVLAIAQAYVLTGRLQAAYDALTT FLSKSKLFDQNHLVVCTILFQLYRMSSRIGNINRLVAILEMLPEEYINDNSSFWIYVAYE VWNHFEELSKYKRILSYVLLNLYDATNRSSSTSKHLSKLLRLYSEQVLEEDVFWEFIAFK FLNESEKFDDSQAIVCYILFELYKIKGRNHSKSILLKKLDSVRVQLKGKTQEFWKHVGFE FLNKDKSSSKSNHIVKYILFELYKVTGRHNSKRMLLFRTLTTLDNWDSIEQDFWKHVAFQ FLNESEKFNDSQAIVCYILFELYKIKGRNNSKSVLLKKLGSVRVQLSGKIQEFWKHVGFE FLNENETFHDSQAIVCYILFELYKIKGRNHSKSILLKKLASVRTQLSERIQKFWKHVGFE FLNESEKFNDSQAIVCYILFELYKIKGRNHSKDVLLKKLGSVRTQLGGKIQEFWRHVGFE FLNESAKFNDSQAIVCYVLFELYKIKGRNNSKSVLLKKLGSVRAQLGGKIQEFWKHVGFE ------------------------------------------------------------ YWENM-AAESHKELVSSLLVHLYKQTRRKRSLLRHLAEITESFDPVNVRQSYYWKFIGFQ FFNKFDSLTYEQRVISYVLFQLYQASHRGHSKSLLLKKLYEHFSSDEVAKDIFWKSIGFK LTHESLATPKALPGLIGTLIAVYENTHNTKKLTDLLLKVLEKLLYTPKELLSFAKIVAFK FLEKTGSLTWAARVVCYLLFQLYQESNKLTASNALLEKLYNLNSDTEIKEDPFWRFIAFN ISNDQFDNEKILPGLIGVLIKLYEELNLTKNLEILFNNLVEKFVSTDHNVIQFVKIIGFK LTHESLTTSKVLPGLIGTLIAIYERTHNNKKLTDLLLKVLEKLLYTPQELFKFAKIVAFK LANESLNEMIVKPGIVGTLITVYEKQHNLAKLKKLLKTLVEKFLYSPEDSFKFAKIVAMK LTEESLAQPVVSPGLVGTLIGVYEKTHSSKKLTDLLVKVLEKLLYTPQDLFKFAKVVAFK LVEVESSPETLHASIFGLIFTLYEQRNYSKKLNSLQYALLQKFESLGSEVLQFVRAFAFK LVDFNLEQPIVTPALVGTLIKVYESLNLTSSLSKLLTKLVTKLLATEEKVMQFIRIIGFK ------------------------------------------------------------ FLKKSVKISENDATVCYALFELYNLVNRSSSKAGLLQRILS---SKSESSIAFWKHVGFQ YINSLPENLAPYPGLIAATSSIARLMGKKKLALKLIEKANTQWQKNSAPYSA-SLAYALS ALANGNIEKSREILQRLSTDQTNITLINAVLSSSESAFDEAVRLVEDIDVEQIRSAGIRP FLEQGQTQKAERIFRALAAKDNNSAKADASDLGDYVDANDINGVIVDVNVDSLLNAGISV LLSIGNIKESKALLRELSSFNKDNELVNRIVSSNSLDIAQGIDLVRNIDVKELIQLGVKP NLTIGQTKDAKKIFDVIKQHDNNE-LIESILSGESFNIEKCSELVADIDVDELIASGIKP LLSMGNAKESKALLREISNFSKGDALVDRVVSSDSLDIAQGIDLVRDIDIDKLIQLGVKP LLSMGNIKESKALLKELSRFGNDKEIIDRIVSSSSLDIAQGINLVRDIDVNELIQLGAKP LLSIGNAKESKALLRVLSSFIKGNGLVDRIVSSNPLDIAQGIDLVRDIDVDELIKLGVKP LLSMGNAKESKALLREVSSFSKGNELVDRVVLSHSLDIAQGIDLVRDIDVDELIRLGVKP ------------------------------------------------------------ LLENQLGS-ARDVFAALAEVRPADSKVLNPADQHELSEDMITDLVRDIDVEALIANGVDP FLSQSSAKEATDIFSEVLKLNSDDQVVNQHASEQTIT-DELESLIHGIDVDELIRAGSTP ALNQGHDKTATQLFEYLYEVNSNDQLIHSILSNTNNDLLPLDELTSKKPIDEILSVDIDT LLAQGFNEKAEEVFSKLQKYVPELP--YRFDSSQQDTLPQLEGPVESVDIENIKGLGTAP LLILQNEN-SSKLFNLLNQINPDDEVSTVLNNSSNSNLSPISKLTSSTQIDELLATSIET ALNQGHDKTATQLFEYLFEVNPSDHLINSILSNTNNDLLPLDELTSKKPIDEILSVDIDT NYAFSED--SRQLFEFLHAANPQDMLINSILSNSNESLQSVADLSSQKSVDSLLAVNMEE ALNQGRDENAKQLFEYLFEVNANDHLINSILTHSNRDLLPLNELTSKKSIDEIVGVDIDT YLNAGSEEKSLHLFGILHSTRKDDS-VSSVVNKDNGSLAPMESLASNESIEELLSVNVET ALNQGNQQGGIQLFEFLSKFNENDSLIKSILTNTSNDLLPVEELSSAKSVEELLSTNIDS ------------------------------------------------------------ LLSIGQVNEGTELLQEILNDPSSVQLIESILSKEEFSKDKGISLVEDIDTEKLIIDGVSP LLESNKPSNAKNLLLKLVEKKPRDEALSGALGTQEVLTREIPDLISGVDVDNLEEVGVI- IATSILRAQKKKLDIKKKKKRTNKFLAKREVKNPDPERWLPLKDRSSYRVNKKQAGKTTQ FENGKSKSSVIKSTPKKKRRVHKKLPKNFDEKKLDPERWLPLKERSTYRVSKNISGKNTQ LATTVNKVQKRKILELKKKRKTDKFLQGRDAKLPDPERWLPIKDRSTYRPKKQQGGKQTQ LDNKANKILKNKMQLKNKKRKEKKFLATHESKFPDPERWVPMRDRSTYRPKRQQLTKQTQ LNTAVSKVQKRKVLELKKKRKIEKFLQGRDTKLPDPERWLPLRDRSTYRPKKQQGAKQTQ LNSTINKVQKRKILELKNKRKIEKFLQGRDAKLPDPERWLPLKDRTTYRPKKLQGGKQTQ LNNAVSKVQKRKALELKNKRKIEKFLQSRDAKLPDRERWLPLRDRSTYRPKKQ-GAKQTQ LNATVSKVQKKKVLELKKKRKIEKFLQGRDAKLPDPERWLPLRDRSTYRPKKQQGAKQTQ ------------------------------------------------------------ -LEASCRIPKASAGKVSKKRRTPKLPKAFDPKQPDPERWLPLRDRSSYRPK-KRHGKQTQ FENKKLHLKRQRLGRVQKKKRVRKLPKSFDPKLPDSERWLPLKDRTSYKPKKKQLAKQTQ LKNKPIKPIVKKVSKITKKKQNNKVLKPIEDLQLDEERWLPMKLRSYYKPTKKASGGGGQ FESKKAHSTQSSIAKVSKKRRVKKSFKNYDPYVANPERWLPLKDRSDFRLKKKSAAKQTQ LQQKPITKPKPSVNKVIKKNRKTKVVKPDAEDSLDKERWLPMKVRSYYKPSKLKKKLGGH LKSKSIKPIVKKSSKITKKKQKNKVLKPIEDLQLDEERWLPLKLRSYYKPTKKKKASGGQ LKSKPIKSITKAATKVTKKKQKNKVVKPEGEFTLDKERWLPLKLRSYYKPTKKKKAGGHQ LKSKPIKAIVKKQNKITKKKKNNKVLKDEKELTLDEERWLPMKLRSYYKPTKKKKSSGGQ LPVNRAVPAKKPVHKVTKKKQKHKFFKPDHEKDLDSERWLPLKLRSNYRPSKLKKKSGGH LKVKSILKPKVSASKVSKKRSKTKVLKPEADLSLDDERWLPMKLRSYYKPTRKKKLGGGH ------------------------------------------------------------ LVSKSSKIQKKKLAHKEKKKAKAKFMTNRDAKTPDPERWLALIDRSTYRPKNKQLAKQTQ -IPQSKKRSAEVSTKTSKKRKT-KIPANADPVTPDPERWLAKRDRSTYKPKKGKKVQNTQ GGASSIEQALDITKKNTKPKKKGKGRK--------------------------------- GFKASSEAKLDITKKAVNAKSKNSRKH--------------------------------- GGAMNSEQALDISKKGKKAKNKKKGRK--------------------------------- GGVMSAEQALDISKKTPAKKNKKKGRK--------------------------------- GGAMNSEQALDISKKGKKPKNKKKGRK--------------------------------- GGAMNSEQALDISKKGKKAKNKKKGRK--------------------------------- GGAMNSEQALDISKKGKKVKNKKKGRK--------------------------------- GGAMNSEQALDISKKGKKSKSKKKGRK--------------------------------- ------------------------------------------------------------ GGVVDAESNLDITKQKKKPKQKKAGHR--------------------------------- GGAVNEEQSLDISKKKKQITQGKKGRK--------------------------------- QGA--TESSTRTTSSSNNKKKKKKGKK--------------------------------- GSAISNEQSLDIS----KKKQKRKARK--------------------------------- QGAVEAVASSSVSNATNNKKKKKKGKK--------------------------------- QGVAEARTTTSLSN---NKKKKKKGKK--------------------------------- GAVESANANPNANAQGAKNKKKKKGKK--------------------------------- QGF--TETSTHSSSSSNNKKKKKKGKK--------------------------------- QGAIESSPAPQTAAHSSSKGKKKKGKK--------------------------------- QGALDPTPAPAPVATSGKNKKKKKGKK--------------------------------- ------------------------------------------------------------ GGAMNAEQSLDITKSNVNKNKKKKGRK--------------------------------- GGAVDLELGSNTAEKTTAKGKKKKGKK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MNNAQISSHQMLIRPVFFIAIFSLRFLSFKTLPSLVYGCHI ------------------------------------------------------------ ------------------------------------------------------------ ------------MTVKSKSRISHYEVLGVPVD-----ASTDEIKLTYRKMLLTLHPDKS- ------------------MQRSFYEILGIESD-----ASNIEIKRAYRAMLLETHPDKSG --------------MSLANSLTHYEILRIPSD-----ATQEEIKKAYRDRLLNTHPDKL- -----------MTATTTNNRLNHYDILSVPSD-----ASQQDIKRAYKERLLNIHPDKS- --------------MSLVNSLTHYEILRIPSD-----ATQDEIKKAYRNRLLNTHPDKL- --------------MSLTSSLTHYEILRIPSD-----ATQEEIKKAYRDRLLNTHPDKL- --------------MSLANSLTHYEILRIPSD-----ATQEEIKRAYRDQLLHTHPDKL- --------------MSLANSLTHYEILRIPSD-----ATQEEIKKAYRNRLLNTHPDKL- ------------------------------------------------------------ ------------------MDGSHYDILGIAVD-----AEPLEVRQAYRQRLLEAHPDKQ- ------------------MNKSHYEVLAVEAG-----ASLSQIKRAYRERLLDTHPDKK- -------------------MISYYKVLGVTPE-----ASIPELKQAYKSKLLTSHPDKI- ----------------MVNNRSFYEILGVEAD-----CNEVDIKKAYKAKLLSTHPDKV- --------MDPYIEDRDIQKRSHYKVLGVVPT-----CNDLDIKSAYKEMLLAHHPDKN- -------------------MISYYDVLGITPE-----ASIPELKQAYKLKLLTSHPDKI- ------------------MHTTHYELLNIPYN-----ATLDEVKRAYKFKLLTTHPDKL- -------------------MISYYQVLEITPE-----ASTAEIKQAYKLKLLSSHPDKT- -------------------MSSHYAVLGVSPS-----ASPEDIRAAYRSLLLTSHPDKT- ----------MTYIDSKEILKSYYEVLLVDSQ-----ALEAEIKASYKKLLLSTHPDKT- YGTRSFSSYMSYIEEADRLARSFYEVLGVEKD-----ASIQEIKKAYREKLLSTHPDKI- -------------MTSKTDSVTHYMVLGVDLD-----SSLEDVKKAYKERLLTSHPDKT- --------------------MNHYTILGLSEPPHVPELTSADLKTAYKQALLKNHPDKL- --KTVPIDSTIKIRSG-----VSINQIQEAYRVLSNDQLRAAYNR--ALN-----DSNKL LNYNSNGNNTSS---------HSVTDIQEAYQTLIDQDLRKKYDE--ELA-----ESFKK -----TKNTNNRVNS------VTINKIQDAYKILSNNQKRGEYDK--TIL-----ENYK- --SSSADSPPPTISH------VTVNQIQEAYRILSKPESRTKYDM--ELL-----ETFK- -----SKSIHDTVSN------VTINKIQDAYKILSNIKTRREYDR--LIL-----ENYK- -----AKKTSNKVNS------VTIDTIQDAYKVLSNIKTRGEYDK--LIL-----ENYK- -----TKNTHGTISS------VTINKIQDAYRILSDIRSRCEYDR--LIL-----ENYK- -----TKNVHDNVNS------VTINKIQDAYKILSNKKTRGEYDR--LIL-----ENYK- ------------------------------------------------------------ -----GGVDK-----------GAVTRIQQAYRVLSDPTQRSAYDG----------ELAVQ ------NGQQARSQAHTQ---ASIEQIQQAYRVLADPTRREQYDA--ELA-----KSYK- ------DNSSAQ---------VDIPLIKQAFATLVDPTSRKQYDK--QLI---------- -----GKDVGNK---------VLIEEIKEAYRVLIESPSREKYDK--ELA-----ESYK- --------GNAS---------TTINSIQEAYKTLIDPELRDQYDD--SLK---------- ------DNSTAQ---------VDIPLIKQAFATLIDPTSREKYDQ--QLI---------- ------SSPDSNG--------ADIAKIVEAYNTLSDATARASYDL--QLH-----NSSK- ------ENISAQ---------VDIPLIKQAFTTLIDPTLRKEYDL--SLL---------- ------GGAVAR---------ISVSRLKEAYEALSDPQCRAQYDK--KLG-----SHSR- ------GEYTSN---------NLITLMKEAYKTLVDPVLKAEYDE--SLT---------- ---NGKVVANNSTRTTSK---DDINSIQVAFKVLTDEVSRKKYDE--SLS---------- -----GIEANIMPS-------TDINRIKEAYKVLSNPVLRAEYNN--MLE---------- ------QEREAYTGS------VQITAITTAYACLSNSKLKKEYDL--SLK---------- A-----------------GF---------NNFGDGL------D--EFN------------ LGF--------------------------HNAGDGL---------DLFS----------- -------KQ---------GFHN-------CG--DGL------D--EFS------------ -------KL---------GY---------TNNGDGL------D--AYS------------ -------RQ---------GFHN-------CG--DGL------D--EFS------------ -------HQ---------GFHN-------CG--DGL------D--EFS------------ -------QQ---------GFHN-------CG--DGL------D--EFS------------ -------LQ---------GFHN-------CG--DGL------D--EFS------------ ------------------------------------------------------------ IA-----AT---------GV---------HGRADAL------D--EHS------------ -------MQ---------GFHN-------TG--DGL------D--EYS------------ --------E--------------------SSKLKGF-------------NINGGGLDI-- -------KQ---------GF---------HNAGEGL------E--DYS------------ --------R--------------------SIQRQGF-----NITGDGLD----------- --------E--------------------SSKLNGF-------------NINGS--GLDI -------SA---------GY---------NLSGRGL------D--VYS------------ --------E--------------------STKLSGF-------------NINGAGLDV-- ------------------PF---------LG--SGL------D--SYT------------ --------R--------------------TIQKQGF-----NLNGDGLD----------- --------K--------------------SVQRAGF-----NISGEGLDSYS-------- ---KSNNLQ---------GF---------HNCGDGL------D--EYS------------ -------NG--------------------ANGVKSG------PGSDVF------------ -------------------------------LDEF------------------------- -------------------------------LDLF------------------------- -------------------------------LDDF------------------------- -------------------------------LDNF------------------------- -------------------------------LDDF------------------------- -------------------------------LDDF------------------------- -------------------------------LDDF------------------------- -------------------------------LDDF------------------------- ------------------------------------------------------------ -------------------------------LDDF------------------------- -------------------------------LDEF------------------------- -YS----------------------------LDDF------------------------- -------------------------------LDAF------------------------- IYC----------------------------LDDF------------------------- -YS----------------------------LDDF------------------------- -------------------------------LDDF------------------------- -YS----------------------------LDDF------------------------- -------------------------------LETF------------------------- TYG----------------------------LNEF------------------------- -------------------------------LDEF------------------------- -------------------------------LDEF------------------------- ---------------------------DLTELEER------------------------- --EFNEEKL--------------------------------------------------- --DYSGDEQ--------------------------------------------------- --SFDDDKL--------------------------------------------------- --EFDEDHL--------------------------------------------------- --SFDEDKL--------------------------------------------------- --SFDEEKL--------------------------------------------------- --SFDEDKL--------------------------------------------------- --SFDEDKL--------------------------------------------------- ------------------------------------------------------------ --EYNEQQG--------------------------------------------------- --TYDPDAA--------------------------------------------------- --EFDNDE---------------------------------------------------- --DFDTNDF--------------------------------------------------- --EMEEEEE--------------------------------------------------- --EFDNDE---------------------------------------------------- --RFVDDNT--------------------------------------------------- --DFDEDKE--------------------------------------------------- ---VETDGI--------------------------------------------------- --DIEEDDE--------------------------------------------------- --ELNEEEL--------------------------------------------------- --IFNPVNY--------------------------------------------------- --EDADGMF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----EYV-MTCP-----------------------RCQ-----SGGGFVL---SEDMLEE ----SFS-MNCP-----------------------RCQ-----ITDGFQL---TEDALEE ----EFR-MNCP-----------------------RCQ-----FVNGFHF---SESLLDE ----SYH-MACP-----------------------RCK-----THKGFDF---TEDTLEE ----EFM-MNCP-----------------------RCQ-----FVGGFHF---SESLLDE ----EFM-MNCP-----------------------RCQ-----FGDGFHF---KESLLEE ----EFM-MNCP-----------------------RCQ-----FVNGFHF---SESFLDE -----FM-MNCP-----------------------RCQ-----FADGFHF---SESLLGE ------------------------------------------------------------ ----VFT-MACP-----------------------RCS-----SAEGFEL---PEQALEE ----EFS-LSCP-----------------------RCQ-----TARGFAT---DEDTLEE -----WS-KSCP-----------------------RCT-----AHNSICL---TETDLEK ----TFR-MSCP-----------------------RCH-----TADGFEF---TEDVLEE ---CKWL-KDCP-----------------------RCQ-----FPKSIKF---KESDLIE -----WT-KSCP-----------------------RCT-----AHNSICL---TETDLEK ----SFY-RDCP-----------------------RCE-----LVDGFIL---SEQDLEN ----VWN-KNCP-----------------------RCT-----AHYSMSL---TESDLEK -----WA-RDCP-----------------------RCS-----AQAAIAL---TEADLEA ----EAV-VSCP-----------------------RCQ-----IAKGMVL---SEENLAE ----KYY-KNCP-----------------------RCQ-----FPKSIQV---SEADLEH ----HYT-LDCP-----------------------RCK-----AKEGFQL---TEETLEE ----SWY-KPC------------------------RCG-----EAGGYVL---TEEHLEN CIED-------------------------------------------------------- HAID-------------------------------------------------------- CIDN--INIIEQSRD--------------------------------------------- YGQE--RPDGE------------------------------------------------- CIDN--VDAMERSHS--------------------------------------------- CIDN--ENVNEWDQS--------------------------------------------- CIDN--TNVTERNHS--------------------------------------------- CIDN--VNIAEQNHS--------------------------------------------- ------------------------------------------------------------ NATA--RPGG-------------------------------------------------- HAME--RDHG-------------------------------------------------- GTPD--KDG--------------------------------------------------- HCME-------------------------------------------------------- -------NGTEDGDN--------------------------------------------- GTPD--KDG--------------------------------------------------- GTSN--GDGGFD------------------------------------------------ GTPD--KDG--------------------------------------------------- GTPD-------------------------------------------------------- -------NGTSDGNG--------------------------------------------- GTAD--GTG--------------------------------------------------- HVTE--NDATQTGFQ--------------------------------------------- NEKY------YEGVDVQFHE---------------------------------------- -----------------------------------G----------LTESEEQGYQ---- -------------------------------------------------YEGGGYF---- -----------------------------------G----Y------------------- -----------------------------------G----F------------------- -----------------------------------G----Y------------------- -----------------------------------G----Y------------------- -----------------------------------G----Y------------------- -----------------------------------G----Y------------------- ------------------------------------------------------------ -----------------------------------G------------------------ -----------------------------------G----L------------------- -----------------------------------G------------------------ -----------------------RSLG--------G----FY------------------ -----------------------------------G------------------------ -----------------------------------G------------------------ ------------------------------------------------------------ -----------------------------------G------------------------ -----------------------------------G---------------AGGLQ---- -----------------------------------G------------------------ -----------------------------------G------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VLTQC -------------------------------------------------------VLVQC -----------------------------------------------------Q-LLTQC -----------------------------------------------------Q-VLAQC -----------------------------------------------------Q-LLTQC -----------------------------------------------------Q-LLTQC -----------------------------------------------------Q-LLTQC -----------------------------------------------------Q-LLTQC ------------------------------------------------------------ -----------------------------------------------------MQVIVQC -----------------------------------------------------Q-VLLQC ------------FD-----------------------------------------IIVQC -------------------------------------------------------VVVQC ------------FD-----------------------------------------IIVQC ------------FD-----------------------------------------IIVQC -------------------------------------------------------IIAQC ------------YD-----------------------------------------IIVQC -------------------------------------------------------LAAPC ------------YD-----------------------------------------IIVQC ------------YN-----------------------------------------LIVQC -------------------------------------------------------LLVQC -------------------------------------------------------IVVQC TACSL----WLKVNF--FINDEEE------------------------------------ SACSL----WLKVLF--DVMEE-------------------------------------- SACSL----WLKVNF--DVEED-------------------------------------- NSCSL----WLKVNF--DVADDYSDE---------------------------------- SACSL----WLKVNF--DIEEEQEGQ---------------------------------- SACSL----WLKVNF--DVEEE-------------------------------------- SACSL----WLKVNF--DVEEELAGQ---------------------------------- SACSL----WLKVNF--EVEEE-------------------------------------- ------------------------------------------------------------ AACSL----WLKVDF--DIVYTSE------------------------------------ SSCSL----WLKVNF--DIVEEYESS---------------------------------- NSCSL----WIQVKY---YEE--------------------------------------- GACSL----WLNVNF--EVVDDDES----------------------------------- ESCSL----WIKVKY---YEINEEDDE--------------------------------- NSCSL----WIQVKY---YEE--------------------------------------- SSCSL----WIQITY---FESEE------------------------------------- NSCSL----WIQVKY---YEE--------------------------------------- SSCSL----WITVQY--EEVEESE------------------------------------ SSCSL----WIKVKY--YEEIETDLEDE-------------------------------- DSCSL----WLIVNY---YEGESEDNS--------------------------------- SSCSQ----WLKVHF--DVGDAYE------------------------------------ GTCSL----WITVQY--GVEEE-------------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------WNPFKPQVAE-DLPGQKILLEDTRPKFQSDSKKEQASLRAAWES ----------------VWPFSEASTEVEEQGQKFLFEDTKPKFNNESSQERASLKEAWNT ----------------WWPWSQQQQQEDRPGQKILLEDTPPKFTNDSNQERATLKEAWDS ----------------WLPSFPQQQQEEKPGQKILLQDTKPHFNDPTAIDSQTFKQAWNT ----------------WWPWSQKQQQQGKAGQKILLEDTPPKFADDSNQERATLKEAWDS ----------------WWPWSQTQQ--ERPGQKILLEDTPPKFADDSNQERATLKEAWDS ----------------WWPWSQAQQQQDRAGQKILLEDTPPKFADDSNQERATLKEAWDS ----------------WWPWSQTQQQQDRPGQKILLEDTPPKFADDSNQERATLKEAWDS ------------------------------------------------------------ ----------------WWPFSEQDQVAQRPGQRLLLEDTRPRFDTQSARERATLADAWKT ----------------VWPFSKKKEQEETPGQKFLLEDTKPRFANESQREQAQIRDAWNT ----------------WFGGGPSKVSIPEEKTQQYLEDLPPKFEDSPIERQATLMDAAQR ----------------VWPFSNTERVSVVPGKKYLLEDTKPRFANESQQEQATLQKAWET ----------------WFGSSSSVSQTAQP--QQFLEDLPPKFEDNSVQKPPAYSDALKE ----------------WFGGGPSKVSIPEERQQQYLEDLPPKFEDSPIERQATLMDAAQQ ----------------WFGGGPAKVSIEEPPHQQYLEDLPPKFADDQTQRQATLSDAAKM ----------------WFGSGPSKLSTEEPKTQQFLEDLPPKFEDSPIEREATLMDAAKQ ----------------WFGGTPSKVSAEADQDVQLLEDLTPKFADQPTAKQPTIVDAFER ----------------WFGGSPLKLSVSEPATQQYLEDLPPKFEDKPVRREPTLIDAAKQ ----------------WFGGSPAKVSNTTSQEQQFLEDLPPKFEDTPRPPESMYREAFKQ ----------------WWGSSDSNENTNKKGQKILLEDTRPKFKGESQNEQNQLKQAWDS ----------------MWPFNPQDQDGSAPSDGKMLDDTKPRFDLEIQEKEAELSNVVSQ ISWNDFTEKLTSIPCFRDAGMVGFSSMFVTGSVILLYHKNINKAMNWAVGGLMLGSIVGW IDVKDFSEKVLSIPCFRDAGIGGFTSMFVVGSVMFLYHKNPARAANWGVGGFILGSIVGW VRWGDFSERLTSIPCFRDAGMLGFSSMFLMGSIIFIYHKSPAKATNWAMSSLILGSIVGW LSWKEFTEKLTEIPCFRDAGMVGFSSLFVVGSLMFIYHKNPMKATNWGLGSLLLGSMVGW IRWSDFSQKLTSIPCFRDAGMLGFSSMFLMGSIIFIYHKSPTKATNWAMSSLILGSIVGW IRWGDFSQKLTSIPCFRDAGMLGFSSMFLMGSVIFIYHKSPTKAANWAMSSLVLGSIVGW IRWSDFTQRLTSIPCFRDAGMLGFSSMFLMGSVIFIYHKSPTKAMNWAMSSLILGSIVGW VRWSDFTQKLTSIPCFRDAGMLGFSSMFLMGSIIFIYHKSPTKAMNWAMSSLILGSIVGW ------------------------------------------------------------ VRWEDFSERMAGIPCFRDAGMAGFSAMVVAGSVTFLFHKNPVRAANWGVGGLLLGSIVGW LSWQDFSAKLTSIPCFRDAGMSGFTSMFVVGTVIFLYHKNPARAANWSIGGYMLGSIVGW IKLSDFTDRFISMPCFREAMITGFQAMGVLGVVTFLIHKNVQKTMNWSVGGFFLGNIIGW ISWNDFSERLTKIPCFRDAGMTGFTSMFVLGSVMFLYHKNPSRAANWAVGGFMLGSIVGW FKLSDFSSHFVSMPCFREAMITGFQAMGVLGTVTFLIHKNPNKSINWAVCGFFLGNVVGW IKLSDFTDRFINMPCFREAMITGFQAMGVLGVVTFLIHKNIQKTMNWSVGGFFLGNIIGW IKLSDFTDRFVQMPCFREAMITGFQAMGVLGVITFLVHRNFKKSMNWSVGGFFLGNLVGW IKLSDFTERFIQMPCFREAMITGFQAMGVLGVVTFLIHKNIRKSLHWSVGGFFLGNIIGW IKLSDFTENYVSMPCFREAMLTGFQAMGVLGVVTFLIHKNPGKSANWGVCGFFLGSVVGW IKLSDFSERFIGMPCFREAMITGFQAMGVLGTVTFLIHKNVSRSLNWSVCGFFLGNVVGW VKLSDFTSHYVNMPCFREAMITGFQSMGVLGAITFLIHKNPQRSVNWAVCGFFLGNIVGW VSMTDFSEKLTSIPCFRDAGMMGFSSLFVVGSIIFLYHKNPTKATNWGVGSFLLGSIVGW IGVNDF-KTVTQIPCFRDAMITGFITGGSVLGVMLSMRRSTLSAANWAIGGFTIGAVAKW EQCRMKRKRSFQVAQMAMEEHDPKLLDQWEGNGPSDSKPWYKFW---------------- EQCRMRRRRSFQVAAMAKQKNIDTVKKEWEE-GSRNSKPWYKFW---------------- EQCRLKRQKSFQIAQLAKEVHDPALPEQWEASQGSSEKKWYKFW---------------- EQCRLKRKHSFEIAQLAINQHDERLVKQWEAKSEKENKSWYKFW---------------- EQCRLKRQKSFQIAQLAKEPHDPSLPGQWEASQASSEKKWYKFW---------------- EQCRLKRQKSFQIAQLAKEPHDPALPGQWEASQTAPEKKWYKFW---------------- EQCRLKRQKSFQIAQLAKESHDPSLSGQWEASQTSSEKKWYKFW---------------- EQCRLKRQKSFQIAQLAKEPHDPSLPGQWEASQASSEKKWYKFW---------------- ------------------------------------------------------------ EQCRMQRRRSFQVAEMARQDNAQKAGAVSQASELPPKKPWYRFW---------------- EQCRMKRKRGFQVAEMAKQLNDDRVKKEWEGINAMQKRPWYKFW---------------- EQCRSLRRKSFQMIEKAQQERDEKNKKKWAESDDEDLKKFQEFN---------------- EQCRMRRKKSFQTAQMARNVNDDRVKQEWEGADSGSKKSWYKFW---------------- EQCHSIRRKSFQAMEKAKEANQKKNEKKWEEEDDEVMKKFNDIQ---------------- EQCRSLRRKSFQMIEKAQQERDEKNKKKWAEDDDEDLKKFQEFN---------------- EQCRSLRRRSFEMVEKAKREKEERHRKKLEELDMDDVKRFEEFN---------------- EQCRSLRRRSFHMVEKAK-EREEKNRKKWNEGEDEDLKKFQEFN---------------- EQCRSIRRRSFQTVEAAKQANQEKMRKKHEHTHDDSLEKFNEVQ---------------- EQCRSIRRRSFQMMEKAKQAKEERNAKSWEKEEDEQYQKFQEFN---------------- EQCRSLRRKSFETVEKARQKNQEKQAKKWEETSDEQMKKWKEVQ---------------- EQCRAKRRRSFQNAQRAKEQHDERLVNQWDKSPTNEGKPWYKFW---------------- EMCRYNRKQSFENAALAHQ------------EEGKE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------MFAS --------------------------------------------------MLRSAAVRRS -----------------------------------------------------MLQRSGA -------------------------------------------------------MLRTA -----------------------------------------------------MFQRSGA -----------------------------------------------MEYSKVMFQRSGA -----------------------------------------------------MYQRSGV -----------------------------------------------------MFQRSRA ------------------------------------------------------------ -------------------------------------------------MIRSGSVRLLR --------------------------------------------MLRSAAISHGRGYAVL -------------------------------------------------MLSFKQFRVST ------------------------------------------------------MPGKHN -----------------------------------------------MSPVLKRFLKPRP -------------------------------------------------MLSFKQFRVSS -------------------------------------------------MSSRLLRRSLP -------------------------------------------------MLSIRNITRRS ------MATFYRPGISSGLFRPQNLVRVQKQQWAHACTR----TSIIVTPTRQKAKNQSG ------------------------------------------------------------ ------------------------------------------------------MYGFSR ------------------------------------------------------MLRPNP -------------------MLRVGRIGTKTLASSSLRF-----------VAGARPKSTLT TTRCVTLKCRTVRYKSS-FAVALE-----------TAS-KLVSPRLLWN----------- LSKGEVSSLLSYRYKSS-FATALN-----------TAA-RLVTPKALLN----------- ARHSKLLLPRGCRLKSS-FAVALN-----------AAS-RLVTPKILWN----------- TGNARRQTLRLYRYKSS-FAVALA-----------AAT-KLVTPEIFQK----------- AHHIKLISSRRCRFKSS-FAVALN-----------AAS-KLVTPKILWN----------- AHHIMRLSPRRCRFKSS-FAVALN-----------AAS-RLVTPKILWN----------- THYIRLLSPRRCRLKSS-FAVALN-----------AAS-KLVTPKILWN----------- AHHIKLISPRRCRFKSS-FAVALN-----------AAS-KLVTPKILWN----------- ------------------------------------------------------------ ETSAAGRCYTSRRSKST-FETAMD-----------AVT-RLVTPASWLNR---------- RASKSTATLMQIRIKSS-FAAALQ-----------TAA-RLVTPNVLLN----------- SSLLTRRIRSRHHSSST-FKTAVE-----------TAE-KLVTPPTSKFS---------- ALITQGRRILNIRRKSS-FAAALE-----------TAA-KLVTPKVLLH----------- IISLRFHSSGQSQSINT-FQTAVE-----------TAE-KLVQPQNDNTFN--------- SSLLTKRIRSRHHSSST-FKTAVE-----------TAE-KLVTPPTSKFL---------- SYLARASYST--NSNSS-FKTAVE-----------TAE-KLVSPTSSSKFQ--------- PRLLKTRCFVNNYSNST-FKTAVE-----------TAE-KLVSPPASKFE---------- PSTMSHFRPRNFRLSPL-LASAVRSVHTNTFPAAVEAAEKMVQPRKSAFS---------- ----MALSRSSSTSAST-FKTAVE-----------TAE-KLVQPQLSLTFH--------- VVIRPSMGIMALRHTST-FKTAVE-----------TAE-KLVSPSSRASFN--------- SLYSKITHLKCHRYKSS-FASAIA-----------AAS-KLVTPKIMLR----------- EAVLETTGLLKTTPQNPEWSGAVK-----------QAS-RLVETDTPIR----------- -----------------------------NPISL------VSNEMNTLAKNI---MALIG -----------------------------NPVSL------VSNEMNTLAKNI---VTLIG -----------------------------NPISL------VSKEMNTLAKNI---VALIG -----------------------------NPLSL------VSNEMNTLAINI---MSLIS -----------------------------NPISL------VSKEMNTLAKNI---VALIG -----------------------------NPISL------VSKEMNTLAKNI---VALIG -----------------------------NPISL------VSKEMNTLAKNI---VALIG -----------------------------NPISL------VSKEMNTLAKNI---VALIG ------------------------------------------------------------ -----------------------------SPTFL------VSDEMKTLSKNI---ARLIG -----------------------------NPLSL------VSKEMNTLPNNI---VSLVG -----------------------------DPFSI------VSHEMSNLAKSI---ANLIG -----------------------------NPVSL------VSKEMNTLAKNI---VALMG -----------------------------DPFSI------VSHEMSNLAKLI---ANLIG -----------------------------DPFSI------VSHEMSNLAKSI---ANLIG -----------------------------DPFSI------VSHEMSNLAKSI---ANLIG -----------------------------DPFSI------VSHEMSNLAKSI---ASLIG -----------------------------DPFSI------VSHEMSNMAKSI---AQLIG -----------------------------DPFSI------VSHEMSNLAKSI---ANLIG -----------------------------DPFSL------VSHEMSNLAKSI---ASMIG -----------------------------NPISL------VSNEMNNLAKHV---MGLIS -----------------------------DPFSI------VSQEMSTLANNI---GSLIG SGHP--TLNRVTSYYFET--EG-KKVRPLLVLLLSRALSE-IPLKERDNIPIDTTDVPED SGHP--LLNRISGYYFEA--EG-KKVRPMLVLLLSRALSQ-IPLEERDRIKIDYTDVPED SGHP--LLNKVTSYYFET--EG-KKVRPLLVLLLSRALSE-IPLEERNHLKIDRADVPED SGHP--TLNRVTSYYFEA--EG-KKVRPLLVLLLSRALSA-IPVEQRNRIAIDEFDFSND SGHP--VLNKVTSYYFET--EG-KKVRPLLVLLLSRALSE-IPMTERNHLKIDKSDVPED SGHP--VLNKVTSYYFET--EG-KKVRPLLVLLLSRALSE-IPLTERNHVKIDHLDVPED SGHP--VLNKVTSYYFET--EG-KKVRPLLVLLLSRALSE-IPLTERNHFKIDTSDVPED SGHP--LLNKVTSYYFET--EG-KKVRPLLVLLLSRALSE-IPLTERNHLKIDNSDVPED ------------------------------------------------------------ SGHP--VLNRVTSYYFDS--GG-KKVRPMLVLLLSRALSE-IPLDQRDRMRIDYTDVPED SGHP--TLNKETGYYFEA--EC-KKARPLLVLLLSRALSE-IPIEERNRITVDYTDVPED SGHP--TLNRVSSYYFEA--EG-KNVRPLIVLILSKALSK-IPLEQRNRIPIDTIDVTEQ SGHP--TLNRVTGYYFEA--EG-KKVRPMLVLLLSRALAE-IPLEERNSIRIDATDVPDD SGHP--TLNRVSSYYFEA--DG-KNVRPLIVLLLSKALLN-IPIEERNRITIDSSDVTTQ SGHP--TLNRVSSYYFEA--EG-KNVRPLIVLILSKALLR-IPIEQRNRIPIDTIDVTEQ SGHP--TLNRVSSYYFEA--EG-KNVRPLIVLILSKALLK-IPRLERQRIPIDEYDVTQQ SGHP--VLNRVSSYYFEA--EG-KNVRPLIVLILSKALSK-IPIEQRNRIQIDTFDVTDQ SGHP--TLNRVSSYYFEA--EG-KNVRPLIVLLLSKALSA-IPIEERDRVPIDYLDVTDQ SGHP--TLNRVSSYYFEA--EG-KNVRPLIVLLLSKSLAA-IPIEQRNRIKIDTYDVTNQ SGHP--TLNRVSSYYFEA--EG-KNVRPLIVLLLSKALSK-IPVEQRNRTAIDDLDVVDQ SGHP--TLNRVTSYYFEA--EG-KKVRPLLVLLISKALST-IPINERNNLKIDKSDIPDD SGHP--TLNKVATYYFQS--EG-KHVRPLIVLLLSRALSA-IPESERDRGTFDASDVTEN PMYSKLSS---NSSLFDVPVKSISPLHILHGIKP----------LN---PLTKGPEPITQ PVYSKVQH----SRLFENVPASISPLHILHGIKP----------LN---PLTKGPEPLPQ PIYSKPSQ----NQLFQRPVNSISPLHILHGIKP----------LN---PLTKGPEPLLE KKLAKIPG---IGSLFDLPLNNISPLHVLHGIKPLND-------------LTKMASSFPE PIYSKPSQ----NQLFQRPASSISPLHILHGIKP----------LN---PLTKGPEPLPE PIYSKPSQ----NQLFQRPVNSISPLHILHGIKP----------LN---PLTKGPEPLPE PIYSKPSQ----NQLFQRPSNSISPLHILHGIKP----------LN---PLTKGPEPLPE PIYSKPSQ----NQLFQRPANSISPLHILHGIKP----------LN---PLTKGPEPLPE ------------------------------------------------------------ PVYSQVPK----SILFEHPVNNISPLHILHGIKP----------LN---PLTKGPEPLPQ PVYSKPPQ----SLLFQHPARSISPLHILHGIKP----------LN---PLTKGPEPLPK KSFNGTPTKQNSTIAGKSIDDSLSPLAILHGINPKVI-------LD---PLSKPMDKLPI PVYSKPPQ----SLLFQHPAKSISPLHILHGIKP----------LN---PLTKGPEPLPE PQFAGTPS--NDSIAGKSVDESISPLTILHGINPKVI-------LD---PLSKPMDELPK KSFNGTPTKQNSTIAGKSIDDSLSPLAILHGINPKVI-------LD---PLSKPMDKLPI AHIKGTPQYGQESIAGNSVDDSLSPLRILHGINPKII-------LD---PLSKPMDQLPE TKFNGTPTTENSTIAGKSVDDSLSPLAILHGINPKVI-------LD---PLSKPMDRLPI PVYPGTPQ--ETVLAGQSPNESISPLAILHGINPRVI-------LD---PLSKPLDRLPE PHYNGTPT--ETVVAGNSVDDSISPLAILHGINPRVI-------LD---PLSKPMDKLPE QPFKGTPT-SHTVVAGKSVDDSISPLAILHGINPKVI-------LD---PLSKPMDALPE PVYSQPPQ----LTILENPLSNISPLHILHGIKP----------LN---PLTKGPEPIPE VGELNPE---------PSINDPLSPIEILHGINPDIV-------LN---PLSRPSDPLPY PEFDQ----------ERGILPKQR--RLAEIVEMIHTASLLHDDV--IDYSDTRRGR-PS EFDRA-----------RGILPKQR--RLAEIVEMIHTASLLHDDV--IDHSDTRRGR-PS KDFDK----------ERGILPKQR--RLAEIVEMIHTASLLHDDV--IDYSDKRRGR-PT VDFDK----------ERGILPKQR--RLAEVVEMIHTASLLHDDV--IDHSDTRRGK-PS ETFDK----------QRGILPKQR--RLAEIVEMIHTASLLHDDV--IDHSDTRRGR-PS EDFDK----------KRGILPKQR--RLAEIVEMIHTASLLHDDV--IDYSDTRRGR-PS ENFDR----------KRGILPKQR--RLAEIVEMIHTASLLHDDV--IDHSDTRRGR-LS ETFDK----------KRGILPKQR--RLAEIVEMIHTASLLHDDV--IDHSDTRRGR-PS ------------------------------------------------------------ EFDRE-----------RGILPKQR--RLAEIVLMIHTASLLHDDV--IDHSGTRRGK-PS EFDQK-----------RGILPKQR--RLAEIVEMIHTASLLHDDV--IDHSDARRGR-PS INGHNKPGDKDNSQGQLDILPKQR--RLAEIVEMIHTASLLHDDV--IDLSDSRRGR-PS EFDKE-----------RGILPKQR--RLAEIVEMIHTASLLHDDV--IDHSDTRRGR-DS FDALN------------GILPKQR--RLAEIVEMIHTASLLHDDV--IDLSDTRRGR-PS IGGSNKLEDKENSQGQLDILPKQR--RLAEIVEMIHTASLLHDDV--IDLSDSRRGR-PS IDKLN------------GILPKQR--RLAEIVEMIHTASLLHDDV--IDLSDSRRGR-PS LDGNT-----------TGILPKQR--RLAEIVEMIHTASLLHDDV--IDLSDSRRGR-PS LDAAN------------GILPKQR--RLAEIVEMIHTASLLHDDV--IDLSDARRGR-PS FDAMN------------GILPKQR--RLAEIVEMIHTASLLHDDV--IDLSDSRRGR-PS FDASN------------GILPKQR--RLAEIVEMIHTASLLHDDV--IDMSDARRGR-PS ASFDN----------DNGILPKQR--RLAEIVEMIHTASLLHDDV--IDHSETRRGR-PS ESN--------------GILPKQR--RLAEIVEMIHTASLLHDDV--IDNSATRRGS-PT GNVAFSNKMAVLAGDFL----LGRATVA---------IS--------RLKNPEVVELMSN GNIAFTNKMAVLAGDFM----LGRATVA---------IS--------RLRNPEVVELVSN GNAAFTNKMAVLAGDFL----LGRATVS---------IS--------RLHNPEVVELMSN VNSTFTNKMAVLAGDFL----LGRATVA---------IS--------RLRNREVVELMSN GNAAFTNKMAVLAGDFL----LGRATVS---------IS--------RLHNPEVVELMSN GNAAFTNKMAVLAGDFL----LGRATVS---------IS--------RLHNPEVVELMSN GNAAFTNKMAVLAGDFL----LGRATVS---------IS--------RLHNPEVVELMSN GNAAFTNKMAVLAGDFL----LGRATVS---------IS--------RLHNPEVVELMSN ------------------------------------------------------------ GNVAFTNKMAVLAGDFL----LGRATVS---------IS--------RLRNPEVVELVSN GNVAFTNKMAVLAGDFL----LGRATVS---------IS--------RLRNPEVVELVSN GNIAFTNKMAVLAGDFL----LGRASVA---------IA--------RLRNPEVIELLST GNVAFTNKMAVLAGDFL----LGRATVA---------IS--------RLRNPEVVELVSN GNIAFSNKMAVLAGDFL----LGRASVA---------IA--------RLRNPEVIELLST GNIAFTNKMAVLAGDFL----LGRASVA---------IA--------RLRNPEVIELLST GNVAFTNKMAVLAGDFL----LGRASVA---------IA--------RLRNPEVIELLST GNIAFTNKMAVLAGDFL----LGRASVA---------IA--------RLRNPEVIELLST GNIAFTNKMAVLAGDFL----LGRASVA---------IS--------RLRNPEVVELIST GNIAFTNKMAVLAGDFL----LGRASVA---------IA--------RLRNPEVIELLST GNVAFTNKMAVLAGDFL----LGRASVA---------IA--------RLRNPEVIELLST GNKAFTNKMAVLAGDFL----LGRATVS---------IS--------RLRNPEVVELMSN GNVAFGNKMAILAGDFL----LGRASVA---------IA--------RLRNAEVIELLST SI--ANLVEGEFMQLKNMAVE----DQPLVGSKNDKILPPPSKKLELKEHDYRVATPEA- SI--ANLVEGEFMQLKNTAID----ADHTTFNNGTQHIPPPPTKFELTEHEYRVPTSSTT SI--ANLVEGEFMQLKNTSID----PDTDTIDNGHKLLPVPSKKLEVKEHEFRVPSRQQ- SI--ANLVEGEFMQLKNVAID---NDVSYITDGGKKQLPLPTGKLDLPVHDYSVPIL--- SI--ANLVEGEFMQLKNTSID----ADIDTIENGHKLLPVPSKKLEVKEHDFRVPSRQQ- SI--ANLVEGEFMQLKNTSID----EDIDTIENGHKQLPVPSKKLEVKEHEFRVPSHQQ- SI--ANLVEGEFMQLKNTSTD----ADIETIENGHKPLPIPSKNLEVKEHEFRVPSRQQ- SI--ANLVEGEFMQLKNTSTD----ADIDTIENGHKLLPIPSKKLEVKEHEYRVPSRQQ- ------------------------------------------------------------ CI--ANLVEGEFMQLKNTVVD----GDLETINNGTQQIPPASKTIPLPVHDYRVNTTL-- SI--ANLVEGEFMQLKNTAID----PDLDTIGNGAHSLPPPSTKLIHPVHDYRVPVPQ-- TI--ANLVEGEFMQLKNTVLQ-NNNNDEIFNDGDVKSIPQPTGKVPTKLHQYSVQQQQRT SI--ANLVEGEFMQLKNTVVD----GDLSTIANGAQKIPPPSKKLANPVHEYRVPANQ-- TI--ANLVEGEFMQLKNTVMS-NEGPDSITNDGDIKNIPKATGKVPTVEHEYSVTA---- TI--ANLVEGEFMQLKNTVLQ-NNNNDEIFNDGDVKSIPQPTGKVPTKLHQYSVQQKNGG TI--ANLVEGEFMQLKNTVMSSKEELNMINNDGELKRVPEPTGKVPTKQHEYSVSPASTT TI--ANLVEGEFMQLKNTVIQ-NNNDDQIVNDGEVKEIPRPTGKVPTKLHDYSVRT---- SI--ANLVEGEFMQLKNTVLT---DDKTVNNDGDEKVVPTPTGKVPVEQHEYSVASPGQS TI--ANLVEGEFMQLKNTVMS--NDSQSIVNDGEKKVIPEPTGKVPTKQHEYSVST---- TI--ANLVEGEFMQLKNTVLN---QSSDINNGGESKPVPTPTGKVPTKQHEYSVQT---- SI--ANLVEGEFMQLKNTAVD----NNLNTIDEGRKELPPSIGKFTNDLHDYRVPIND-- TI--ANLVEGEFMQLKNTIVD--------------------------------------- ----------------TGSFSHEEVINIAF----EYYLHKTYLKTAALISKSSRAAAILS N---------------GTQLSHDQLVDMAF----DYYLHKTYLKTAALISKSCRAAAVLS ----------------GLQLSHDQLIETAF----EYYIHKTYLKTAALISKSCRCAAILS ----------------SNNLSHQEKVDLAF----EYYLHKTYLKTASLISIALRSTAILS ----------------GLQLSHDQIIETAF----EYYIHKTYLKTAALISKSCRCAAILS ----------------GLQFSHDQLIETAF----EYYIHKTYLKTASLISKSCRCAAILS ----------------GLQLSHDQLIETAF----EYYIHKTYLKTAALISKSCRCAAILS ----------------GLQLSHDQIIETAF----EYYIHKTYLKTAALISKSCRCAAILS ------------------------------------------------------------ ----------------ASGISHEVMIETAF----DYYLHKTYLKTAALISKSCRAAAVLS ----------------DSHIPHEKMIETAF----EYYLHKTYLKTAALISKSCRAAAVLS TNGGNGGDSADA----AVVVDHEINVEAAF----EYYLHKTYLKTASLMSKSCRAAAVLS ----------------GESNLPQNIVETAF----EYYLHKTYLKTASLISKSCRAAAILS ----------------PGEVDHNTNVSAAF----EYYLHKTYLKTASLMSKLSRAAGVLS ----------------DAVVDHNINVEAAF----EYYLHKTYLKTASLMSKLCRAAAVLS TVSSSHSSSSSSSSVEGDVVDHDISVQAAF----EYYLHKTYLKTASLMSKSCRAAAVLS -------------------VDHETNVDAAF----EYYLHKTYLKTASLMSKSCRAAAVLS GE--------------NGQVSHDTNVDAAF----EYYLHKTYLKTASLMSKSARSAAVLS ----------------PAEVDHITNVDAAF----EYYLHKTYLKTASLMSKLSRAAAVLS ----------------PADVDHETNVNAAF----EYYLHKTYLKTASLMSKSARAAAVLS ----------------NLLTSKDAMINTAF----EYYLHKTYLKTASLISMACRSSAILS --------------------NSEIANKATF----EYYIHKTYLKTASLMSKSCRAAAVLS GA--------RDPVI----EECYSFGRNIGICFQLVDDLLDFSVSAK------DLGKPA- GV--------RDPII----EECYEFGKNLGICFQLVDDMLDFTISAK------DLGKPA- GS--------TPAVV----DECYDFGRNLGICFQLVDDMLDFTVSGK------DLGKPS- GA--------NHQVI----DECYEYGRNIGICFQLIDDLMDFTVSKK------DLGKPV- GA--------SPAVI----DECYDFGRNLGICFQLVDDMLDFTVSGK------DLGKPS- GA--------TPAVI----DECYNFGRNLGICFQLVDDMLDFTVSGK------DLGKPS- GA--------SPAVI----DECYDFGRNLGICFQLVDDMLDFTVSGK------DLGKPS- GA--------SPAVI----DECYDFGRNLGICFQLVDDMLDFTISEK------DLGKPS- ------------------------------------------------------------ GA--------RDPIL----DECYHFGKNLGICFQLVDDMLDFTTSG-------ELGKPV- GA--------NDPVI----ENCYEFGKNLGICFQLVDDMLDFTVSAK------ELGKPA- GA--------QDDII----ENCYQFGRNLGLCFQIVDDMLDYTSSDK------TIGKPS- GA--------KEPVI----ENCYNFGKNLGICFQLVDDLLDFTVSSK------DLGKPA- GS--------QDNII----ENCYDFGRNLGLCFQIVDDMLDYTSSDT------SFGKPS- GS--------QDDII----ENCYQFGRNLGLCFQIVDDMLDYTSSDK------TIGKPS- GA--------QDDII----ENCYQFGRNLGLCFQIVDDMLDYTSSDA------TFGKPS- GA--------QDDVI----ENCYSFGRNLGLCFQIVDDMLDYTSSDK------AIGKPS- GA--------RDNVV----DSCYDFGRNLGLCFQIVDDMLDYTSSDA------AFGKPS- GA--------HDDII----ENCYEFGRNLGLCFQIVDDMLDYTASDA------TFGKPS- GA--------QDDVV----QNCYDFGRNLGLCFQIVDDMLDYTSSDN------AIGKPS- GA--------SPEVV----DSCYEYGKNLGICFQLVDDMLDFTVSSE------NLGKPA- GA--------RNPIV----DASYKFGKNLGLCFQVVDDMLDYSEGES------HLGKPA- GADLKLGIATAPVLFAWKEDP--SLGPLI--K----RNFSEPGDVEKTV-KSVQDHDGVG GADLELGIATAPVLFAWREDP--SLGPLI--K----RNFSNPGDVEAAA-LAVKKYDGVG GADLKLGIATAPVLFAWKEDP--SLGPLI--S----RNFSERGDVEKTV-ASVRDHDGIA GADLELGIATAPVLYAWREDV--SLGPMI--E----RNFSQPGDVKKAT-EAVHKYGGVE GADLKLGIATAPVLFAWKEDP--SLGPLI--S----RNFSERGDVEKTI-DSVRLHNGIA GADLKLGIATAPVLFAWKEDP--SLAPLI--S----RNFSERGDVERTI-ASVRLHDGIA GADLKLGIATAPVLFAWKEDP--SLGPLI--S----RNFSESGDVEKTI-ASVRLHNGIA GADLKLGIATAPVLFAWKEDP--SLGPLI--S----RNFSERGDVEKTI-ASVRLHNGIA ------------------------------------------------------------ GADFELGIATAPVLFAWKEDP--SLGPII--Q----RNFSQPGDVARAL-EAVHQHDGIK GADLDLGIATAPVLYAWKADP--SLGPLI--Q----RNFSQPGDVERTA-EAVQKFGGVF QADLKLGLATAPILFAWKQEP--KLGDLI--A----RKFNQPGDVEIAR-RAVEKYDGVA GADLDLGIATAPVLYAWKEDP--SLGPLI--Q----RNFSQPGDVERTA-EAVAKYGGVS QADLKLGLATAPILFAWKERP--ELGELI--A----RKFGEEGDVEVAR-KAVEECGGLE QADLKLGLATAPILFAWKQEP--KLGELI--A----RKFNQPGDVEIAR-RAVEKYNGVA QADLKLGLATAPILFAWKKEP--QLGELI--A----RKFNQPGDVEIAR-DAVQKYKGLE QADLKLGLATAPILYAWKEEP--ALGELI--G----RKFSQPGDVEIAR-RAVDKYNGVE QADLKLGLATAPVLFAWRKEP--KLGALI--A----RKFSEPGDVEIAR-RAVERYDGVA QADLKLGLATAPILFAWKEQP--ELGELI--A----RKFSEPGDVEIAR-NAVKKYLGLE QADLKLGLATAPILFAWKERP--ELGELI--S----RKFKEPGDVELAR-SAVDQCNGVE RADLKLGIATAPVLYAWREDP--SLTELI--L----RNFTQPGDVEAAT-KSVIQHNGVQ GADLKLGLATAPVLFAWEKYP--ELGDMI--K----RKFDGPGDVERAR-FLVQQADGLS KTMEFAKEYRNKALQNLKNALPE----------SD------CRSALEFLTNSIVT----- KTNELAKDYCNKALQNLRNGLPN----------SD------ARSALEFLTNSVLT----- KTKALAEEYRDKALQNLRDSLPD----------SD------ARSALEFLTNSILT----- KTRKLAEEYRDKALKNLRSVLPE----------SD------SRSALEFLTNSILT----- KTKILAEEYRDKALQNLRDSLPE----------SD------ARSALEFLTNSILT----- ETKALAEEYRDKALQNLRNSLPD----------SD------ARSALEFLTNSILT----- KTKALAEEYRDKALQNLRDSLPD----------SD------ARSALEFLTNSILT----- KTKVLAEEYRDKALQNLRESLPD----------SD------ARSALEFLTNSILT----- ------------------------------------------------------------ KTAEVAREYRDKALHNLRAALPE----------SD------SRAALEFLTNSILT----- KTKELATEYRDRALKNLRDTLPE----------SD------ARSALEFLTNSILT----- QTKEMATMYCHQALKNLR-VLPE----------SE------ARSALELLTNSVLT----- KTRELAHEYRDRALFNLRSALPE----------SD------ARSALEFLTNSILT----- KTREMAQDYCYKALENLR-VLPE----------SD------ARSALEFLTNSVLT----- QTKEMATMYCHQALKNLR-VLPE----------SE------ARSALELLTNSVLT----- QTREMATKYCMSALENLR-QLPE----------SD------ARSALELLTNSVLT----- KTREMATMYCHEALKNLR-CLPD----------SE------ARSALELLTNSVLT----- QTRKMAQDYCNRALTSLR-VLPE----------SD------ARSALELLTHSVLT----- KTREMAHEYCYKALQNLR-VLPE----------SD------ARSALEFLTNSVLT----- QTRKMAQEYCMKALGNLR-VLPE----------SD------ARSALELLTNSILT----- KTKELAEKYRDAALANLRSSFPE----------SD------ARSALEFLTNTILS----- RTRELAQKYCDEAVANLD-LLPY----------SE------SREALRNLTMKMMN----- RKK-----------------------------------------------------MS-- RRK-------------------------------------------------MSDPTW-- RRK-----------------------------------------------------MS-- RRK-----------------------------------------------------MI-- RRK-----------------------------------------------------MS-- RRK-----------------------------------------------------MS-- RRK-----------------------------------------------------MS-- RRK-----------------------------------------------------MS-- ---------------------------------------------------PNISSMS-- RRK-------------------------------------------------MSRMTD-- RRK-----------------------------------------------------MS-- RTN--------------------------------------------------------- RKK-----------------------------------------------------MS-- RSK--------------------------------------------------------- RTN--------------------------------------------------------- RTK----------------------------------------------------MRD-- RSK-----------------------------------------------------MT-- RTN--------------------------------------------------------- RNK--------------------------------------------------------- RTK--------------------------------------------------------- RRK-----------------------------------------------------MS-- RSK--------------------------------------------------------- -------------CARSLWPFISNING-----------------SVSFLS---------- -------------CDKSLWPQISVASG-----------------GISFLT---------- -------------CSNSIWPTISNLSG-----------------SLSFLT---------- -------------GARSIWSIVSNVNG-----------------SIAFVS---------- -------------CSNGIWPTVSNLCG-----------------SLSFFT---------- -------------CLNSIWPTVSNLSG-----------------SLSFFT---------- -------------CSNSIWPAVSNLCG-----------------SLSFFT---------- -------------CLNSIWPTVSNLCG-----------------SLSFFT---------- -------------CSHSVWPWVSSANG-----------------VASFAL---------- -------------CAATIWPVISIASG-----------------VVSFTT---------- -------------CSSTIWPSVSAAAG-----------------SVSFIT---------- ------------------------------------------------------------ -------------CQYHVLPHISTIAG-----------------SISFLS---------- ------------MFTCSQFSFISSSLS-----------------ILSLSS---------- --------------MPCSISFISTTFS-----------------TTSCIS---------- -------------LCLGWISHVSSSFS-----------------FISGLS---------- -------------TCPSTVSFISSTFS-----------------TISIVS---------- ------------MNSCGLVSPISGFFS-----------------TISLVS---------- ------------MVACSDISYLSGMFS-----------------TLSCTS---------- ------------MDTCGHFVGVSDFFS-----------------TVSLCS---------- -------------CKETLWPEISELTG-----------------TVSFLA---------- -------------MREEALKLISQGLT-----------------QLCIVI---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------SFVSLF------ ------------------------------------------------SFVAQI------ ------------------------------------------------SVVSLF------ ------------------------------------------------SFISLL------ ------------------------------------------------SVISLF------ ------------------------------------------------SVISLF------ ------------------------------------------------SVISLF------ ------------------------------------------------SVISLF------ ------------------------------------------------SFVSLF------ ------------------------------------------------SLVASI------ ------------------------------------------------SFIAQI------ ------------------------------------------------------------ ------------------------------------------------SFVAQI------ ------------------------------------------------WVWAQL------ ------------------------------------------------WMFAQL------ ------------------------------------------------WVFAQL------ ------------------------------------------------WIFAQL------ ------------------------------------------------WMCAQL------ ------------------------------------------------WIFAQL------ ------------------------------------------------WICAQM------ ------------------------------------------------SFVSLM------ ------------------------------------------------WVVALA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P ------------------------------------------------------------ -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------P -----------------------------------------------------------Y Q---------IIETYKDK----------------------TVE-GLSPLFLMCWLSGDIT Q---------LIETYRDK----------------------SVE-GLSPGFLLCWLFGDIT Q---------IIETYRDK----------------------TVD-GLSPYFLLAWLCGDIT Q---------ILETYHDK----------------------TVV-GLSPWFLLAWLCGDIT Q---------IIETYRDK----------------------SVD-GLSPYFLLAWLCGDIT Q---------IIETYRDK----------------------TVD-GLSPYFLLAWLCGDIT Q---------IIETYRDK----------------------SVD-GLSPYFLLAWLCGDIT Q---------IIETYRDK----------------------SVD-GLSPYFLLAWLCGDIT Q---------IIETYRDK----------------------TVA-GLSPLFSSAWVCGDIT Q---------VVETYKEK----------------------SVD-GLSPLCLLCWISGDIT Q---------LIETYKDK----------------------TVE-GLSPIFLLAWLFGDIT ------------------------------------------------------------ Q---------VLETYVDK----------------------TVE-GLSPLFLLAWLMGDIT Q---------IYCNYRNK----------------------SAE-GISPLFLLLWFMGDFL Q---------ILENYRNK----------------------SAE-GISPSFLILWFMGDFL Q---------IVTNYKLK----------------------SAD-GISPSFLLLWFLGDFL Q---------IIKNYTNK----------------------SSE-GISPGFLLLWFMGDFL Q---------IYTNYNAK----------------------SAE-GISPSFLLLWLCGDFL Q---------IIENYKNK----------------------SAE-GISPTFLLLWFMGDFL Q---------IYTNYKNK----------------------SAD-GISPSFLALWFAGDFL Q---------IIETYRDK----------------------TVE-GLSPYFLLAWLLGDIT Q---------CYANFRNK----------------------RVD-GFSFGFLLCWIGGDTF SLIGALMT--GQLKFQIALAIYFLFNDLFVCCQYYYYGVLH------------------- SLIGAVLT--HQLPFQILLAVYYLSNDMLICGQYYYYGILH------------------- SLIGAKLT--GQLLFQIVLAIYFLVNDSFVCGQYYYYGVMH------------------- SLTGAILT--NQLMFQIVLAIYFLLNDMFVCGQYYYYGILY------------------- SLIGAKLT--GQLLFQILLAIYFLLNDSFVCGQYYYYGVLH------------------- SLIGAKLT--GQLLFQIFLAIYFLVNDSFVCGQYYYYGVLH------------------- SLIGAKLT--GQLLFQILLAVYFLFNDSFVCGQYYYYGVLY------------------- SLIGAKLT--GQLLFQILLAIYFLLNDSFVCGQYYYYGVLH------------------- SLLGAVLT--NQLTFQIVLAFYFLLNDLFVCGQYYYYGISH------------------- TLVGAILT--HQLPFQIIQAFYYFSTDLILCYQYYYYGVRW------------------- SLIGALLT--HQLPFQIILALYFMANDMFICGQYYYYGILH------------------- ------------------------------------------------------------ TLVGAVLT--QQLSFQIILALYFLANDLFICGQYYYYGIVH------------------- SFTSCLLN-DVVLKFQVYLSLFFLCNDVTLCYQYYYYNSVY------------------- SFTSCLINIDIVLDFQLYLSVFFLCNDVTLCFQYYYYNSVY------------------- SFTSCLLN-DATLNFQLYLSIFFLCNDITLCFQYYYYNSVY------------------- SFTSCLVNIDTVLKFQLYISVFFLCNDIALCFQYYHYNYVH------------------- SFTSCLLN-DVVLKFQVYLSLFFLLNDVTLCYQYYYYNSSY------------------- SFTSCLLN-DVVLQFQIYLSIFFLCNDITLCFQYYYYNSVY------------------- SFTSCLLN-KVVLKFQVYLSLFFICNDLTLCFQYYYYSVRT------------------- SIIGATLT--NQLTFQILLAIYFLANDLVVCLQYYYYGVLH------------------- ALWGALLT--HQLPFQIFLATYYCGIDAILLSQYFYYETLG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------EN---KLA----------------------TVGHETV---------------- -------RN---QLA----------------------TPGHESA---------------- -------KN---KLA----------------------TIGHEPK---------------- -------EN---KLA----------------------TTGHEPK---------------- -------EN---KLA----------------------TVGHEPK---------------- -------EN---KLA----------------------TIGHEPK---------------- -------EN---KLA----------------------TIGHEPK---------------- -------EN---KLA----------------------TIGHEPK---------------- -------GN---QSA----------------------TAGHESK---------------- -------RN---RLA----------------------APGARHL---------------- -------QN---KLA----------------------TPGHESK---------------- ------------------------------------------------------------ -------GN---KLA----------------------TPGHEKK---------------- -------PRKYGNIE----------------------NLDTEER---------------- -------PR----------------------------LQQQQQQ---------------- -------PR----------------------------TTAFESY---------------- -------TRYTSVEM----------------------DETQNER---------------- -------PR---KHL----------------------QHLQQQA---------------- -------PR----------------------------KHGLMYQ---------------- -------SN---NYK----------------------SVNGLVS---------------- -------EN---KLA----------------------TVSHESK---------------- -------------------------------------YGAHKME---------------- -----------------------PVISSLIDDGIITVDENGLQNT-----------DSRP -----------------------TLEERTRLVRSRGSNPSIQLQR-----------GFKW -----------------------PLLPELAENGQLLREEEDIIRS-----------GSAE -----------------------------PVLESISGVLDVTPDM-----------DEST -----------------------PLLPELVENGELLREEEDMIQG-----------GSSA -----------------------PLLPELAENGELLREEEDIING-----------GSPR -----------------------PLLPELVENGELLREEEEMIQD-----------GSSA -----------------------PLLPELVENGELLREEEDMIQG-----------VESP -----------------------------ISYQEGTQNNDDHHHH-----------HHSP ------------------------------------------------------------ -----------------------ISAERIATISSRGSLNRGLKKK--------------- ------------------------------------------------------------ --------------------------------------------S-----------SDER -----------------------SKGDETMVNTDIKASEDDPVRA-----------NNAS -----------------------QLLLLYVLLNTERSDYSKLTMT-----------NNED -----------------------TPVDILPQPVVIHKDLDEHGEE-----------REIR -------------------RVDDNDGEELPKTPMDNEDVSLYQGQ-----------DIHR -----------------------VLEQSVFSGESETHKTDSIHIR-----------HKRA -----------------------PIATEAATFADAEGNAVDMHSS-----------SNSV -----------------------EIDSGTTTHESLFHTDAETHIT-----------DGSH -----------------------PILASSDILQDGDSENIDTDSL-----------FQRI -----------------------STGPEVTEIEVLDGYTNTPIEL-----------ERKG ETNMEGSRLSNSS----------------------------------------------- WILSFFVSQPG------------------------------------------------- SRSS-------------------------------------------------------- TPNSLEAVRSRNS----------------------------------------------- ESPRS------------------------------------------------------- G----------------------------------------------------------- ESPRS------------------------------------------------------- RS---------------------------------------------------------- TQRS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MAIV----RSRGS--E-------------------------------------------- VHTTANAIHIRSS----------------------------------------------- RDISIYQAQDIQQ----------------------------------------------- QLHEQLLSDESAP----------------------------------------------- ISHAQNIEHSTSE----------------------------------------------- SSSESSSLTPPDG----------------------------------------------- HIRHTRNSESKCP----------------------------------------------- RAIP-------------------------------------------------------- RTNGS------------------------------------------------------- KAPIEIRTKKATP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------NSNSNNKAPSHTLVQSISSSASSNNNSYS -----------------------------------IKHANSNQSTSEDCINSTP------ ------------------------------------------------------------ ------------------------------------DYVTSSPSSYDSTNEEGGRNI--- ------------------------------------------------------------ --------------------------------------TPASNTSSTSSSYNSI------ ------------------------------------TPGSISNSPSGSYS---------- ------------------------------------------------------------ ----------------------------------GGLSVTPSPNYYSISASSSSVPKFIP -IYSGSRAT--------------------------------------------------- -TVQGFPMP--------------------------------------------------- -SRRRSAIT--------------------------------------------------- -SQTRAALI--------------------------------------------------- -SRRRSAIT--------------------------------------------------- -SRRRSAIT--------------------------------------------------- -NRRRSAIT--------------------------------------------------- -SRRRSAIT--------------------------------------------------- -SSPGLWQR--------------------------------------------------- --AAPSPAK--------------------------------------------------- -SWLASLFV--------------------------------------------------- ------------------------------------------------------------ -ASINAGLQ--------------------------------------------------- SINDNQQYL--------------------------------------------------- -SSYNSIND--------------------------------------------------- -SSYNSTDE--------------------------------------------------- -STSGSGII--------------------------------------------------- -PRASNFGS--------------------------------------------------- -NDNKTSVL--------------------------------------------------- -STDNSPIV--------------------------------------------------- -ERSRIMAA--------------------------------------------------- GSVTKAFLA--------------------------------------------------- ---------------------------------------RSLLA-----NALVSVKSSN- ---------------------------------------VVSIA-----QAITGSETVF- ---------------------------------------AALAI-----AHTLSTATAY- ---------------------------------------SAMAL-----ANSIQGASAM- ---------------------------------------AALAI-----AHTISTASAY- ---------------------------------------VALAI-----AHTISTSSAY- ---------------------------------------AALAL-----AHTISRASAY- ---------------------------------------AALAI-----AHTISTASAY- ------------------------------------------------------------ ---------------------------------------GLLAS-----FLVVGRAAAA- ----------------------------------FGNSAHGFPL-----LMSYMTKASG- ------------------------------------------------------------ -------------------------------------------------RRTWLAGLLC- ---------------------------------------KTLAI-----GSILNTSVAA- ---------------------------------------NGNGN-------IIKKSIVG- ---------------------------------------NKSIMKNLAGTIAVHAGRAN- ---------------------------------------KKSIV-----GTMLQAGKAV- ----------------------------------------VAIV-----GAAMQAGVAQ- ---------------------------------------KVAAI-----STILNAGSSA- ---------------------------------------KSIAV-----SSMAQGASAL- ---------------------------------------SALLL-----STQVSAAEAF- ---------------------------------------ASFGASRAAAAPIVMKGVKT- ------------------------------------AQQILS----SLQVPPN------- ------------------------------------PFSKHR----PSPVVPI------- ------------------------------------PLSIAS----DPSHAGP------- ------------------------------------PIPLPG----GGSGDGN------- ------------------------------------PLNVGS----TQSQVGP------- ------------------------------------PLKSSS----TQTQLGP------- ------------------------------------PLNVGSV---QLQVAPP------- ------------------------------------PLNVGS----IQPQMAP------- ------------------------------------------------------------ ------------------------------------PLLRRD----SVAAPPL------- ----------------------------------------------DNTLPPP------- ------------------------------------------------------------ -----------------------------WFSGANGLP--LG----LSAQDAV------- ------------------------------------AMPVSM----GTMADDT------- ------------------------------------AI--LN----TSHAAAL------- ----------------------------------------------AFANDAM------- ------------------------------------AMPLSS----TATTVIT------- ------------------------------------AQPILK----PDGNAVT------- ------------------------------------AMPIFA----KVLTDDD------- ----------------------------------------------STSNIPE------- ------------------------------------PFFSQD----SNTSIAP------- ------------------------------------VVDNTD----AHMSTAA------- -------------------------APYPGHTGRGQ------------------MGVTLS ---------------------------EPPHTSF--------------------IGQLAS -----------------------SGDGFPEHGKTSE------------------LGTILS -----------------------------RYLTNTQ------------------IGTVLS ----------------------------PGDGKNSQ------------------LGTILS -----------------------PSDSLPGHCKTSE------------------LGTILS ------------------------GDGFPNSGKAGE------------------LGTILS ----------------------------PGDDKNSQ------------------LGTVLS ------------------------------------------------------------ -----------------------------PLPSSDP------------------FGIVSS ----------------------------APVPSSSG------------------VGIALS ------------------------------------------------------------ -----------------------------SSPETSH------------------LGVTLS --------------------------LFSSSINKEV------------------LGVFLA -----------------PITTETFCKRDTDGNSTSS------------------VGLYLA ------------------------LDKAQLYTLKDS------------------VGLALA -----------------------------SSDSHDS------------------LGLFLA ----------AGAKGASGVVSLLSIANHASVDSVAN------------------IGLVLA ---------------------------TDGYSGKET------------------LALVLA ----------------------------KESSFGEV------------------LGVLLA -------------------------IPIPGKGPHDHE-----------------IGVLMS ----------------------------IPLLSALT------------------LGIFVS --------WLGASFYVGARIPQLIKNYQRKSTDGLSPFLFATTLLGN------------- --------WVGAMSYFCARIPQLIKNYKRKSTDGLSPLLFISTLIAN------------- --------WIGAFFYVGARIPQLIKNYNRKSTDGLSPFLFATTLFCN------------- --------WAGACFYVGARIPQLYKNYKRKSTDGISPFLFATTLLGN------------- --------WIGASFYVGARIPQLIKNYNRKSTDGLSPFLFATTLLCN------------- --------WMGASFYVGARIPQLIKNYNRKSTDGLSPFLFATTLLCN------------- --------WIGASFYVGARIPQLIKNYNRKSTDGLSPFLFATTLLCN------------- --------WIGASFYVGARIPQLIKNYNRKSTDGLSPFLFATTLLCN------------- --------FLSTFFLIG------------------------------------------- --------WVGASFYFFSRIPQLIKNYRRKSTDGLSPLLFLAALTAN------------- --------WVGAMCYVCARIPQLIKNYKRKSTDGLSPFLFINTLLTN------------- ------------------------------------------------------------ --------WIGALCYVGARIPQLFKNYNRKSTDGLSPFLFINTLIAN------------- --------WSCTCVYVASRCPQLYKNYKRKSVDGISPILFGCALVGN------------- --------WGCTLVYCLSRCPQLYKNYKRKSVNGISPLLFASALMGN------------- --------WGCTIVYCASRCPQLYKNYKRKSVDGILPLLFGAALLGN------------- --------WGGTVLYCLSRCPQLYKNYKRKSVEGISPLLFGAALLGN------------- --------WGCTFVYMSSRCPQLYKNYKRKSVEGVSPLLFGSALMGN------------- --------WGCTLVYISSRCPQLYKNYLRKSVDGISPILFGAALLGN------------- --------WACTFVYMASRCPQLYKNYQRKSVDGISPLLFGAALIGN------------- --------WLGAFFYVGARLPQLIKNYRRKSTDGISPTLFAMTLLSN------------- --------YTSSLLYTVSRIPQVYKNYKRQSTENMGLAMFIAACCGN------------- -ITYNISIFTSCNFLDTE------------------DKMAFIFNE--------------- -VTYTLSIFTSCSYLTDE------------------DKLGFVLNA--------------- -ITYNLSIFTSCQFLTTQ------------------DKTQFIINE--------------- -VTYNVSIFTSCNFLNSD------------------DKIAFVINE--------------- -ITYNLSIFTSCRFLDNQ------------------NKREFIVNE--------------- -ITYNMSIFTSCQFLTSQ------------------NKTEFVMNE--------------- -ITYNVSIFTSCHFLTSQ------------------NKREFIMKE--------------- -ITYNMSIFTSCQFLTSQ------------------NKREFIMNE--------------- -----------------------------------------VSNA--------------- -LTYCVSVFTSCEFLASP------------------DKPAYVWNA--------------- -ITYALSIFTSCDYLDCE------------------DKKSFVLNE--------------- ------------------------------------------------------------ -ITYTVSIFTSCEYLSCP------------------DRLGFAVSE--------------- -LTYTLSILTSCDFVYGD------------------AKSNFFVKE--------------- -LTYTLSILTSCEFAFGS------------------NRQGFILKE--------------- -LTYTLSILTSCSFIFGD------------------DRSEFFYKE--------------- -LTYTLSILSSCEFFEGGA-----------------VQHEFIIKE--------------- -LTYTMSILTSCDFLYDS------------------NKTEFFWRQ--------------- -LTYTLSILTSCEFVFGD------------------SKLEFIMKE--------------- -LTYTLSILTSCDFVNDD------------------LRHEFFIKE--------------- -ITYNISIFTSCNFFDSD------------------DKHEFIMNA--------------- -ATYSMSIFAIGLTLEES------------------VRRAFFIKE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LPF------------IFGSAGTVAF-----------------------DLIY---FYQ-- LPF------------IVGSAGTVVF-----------------------DLIY---FYQ-- LPF------------IFGSAGTIAF-----------------------DMIY---FYQ-- LPF------------IFGSAGTIAF-----------------------DLIY---FYQ-- LPF------------IFGSAGTIAF-----------------------DLIY---FYQ-- LPF------------IFGSAGTIAF-----------------------DLMY---FYQ-- LPF------------IFGSAGTIVF-----------------------DLAY---FYQ-- LPF------------IFGSAGTIAF-----------------------DLIY---FYQ-- LPL------------VYQEPGNXTP-----------------------SAHY-----R-- LPF------------IMGSGGTVVF-----------------------DLIY---VYQ-- LPF------------LVGSVGTVFF-----------------------DLTY---FYQ-- ------------------------------------------------------------ MPF------------IVGSTGTIVF-----------------------DLVY---FYQ-- LPY------------ILGSSGTVVF-----------------------DFLY---FYQ-- LPY------------ILGSAGTIVF-----------------------DIAY---FYQ-- LPY------------ILGSSGTILF-----------------------DLAY---FYQ-- LPY------------ILGSSGTVVF-----------------------DIAY---FVQ-- LPY------------ILGSAGTIVF-----------------------DMAY---FYQ-- LPY------------ILGSSGTIVF-----------------------DVAY---FYQ-- LPY------------ILGSAGTIVF-----------------------DLAY---FYQ-- MPF------------IFGSAGTVAF-----------------------DMIY---FYQ-- APF------------VGAASITVLF-----------------------DFVI---FWQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---YYVLY----------------SRDNKLRELEREIY---------------------- ---HYVLY----------------AEDYNIRRLESDEFTP-------------------- ---YYVLY----------------ATDMQLRELEREIYEPERDNV--------------- ---YYVLY----------------ADDMKWRELEREILEDESD----------------- ---YYILY----------------ATDMQLRELERELYSPEEDSA--------------- ---YYVLY----------------ATDMQLRELERELYEPEEANV--------------- ---YYILY----------------ATDMQLRELERELYNPEEDSV--------------- ---YYILY----------------ATDMQLRELERELYGPEEDNA--------------- -------H---------------------------------------------------- ---HYFLY----------------RQKGQHKQLE-------------------------- ---HYILY----------------ADDVKLRELE-------------------------- ------------------------------------------------------------ ---HYVLY----------------AADMRLRELEAQT----------------------- ----RFLY---------------KGAGRNTTVMSMDDWDHINH----------------- ----KYLY---------------------------------------------------- ----KRLY---------------------------------------------------- ----KYMY---------------SNNSRTTRGTNTMVM---------------------- ----RYLY---------------------------------------------------- ----KYLY---------------RSTGKNTQVMTLENWSSIDM----------------- ----RRIY---------------------------------------------------- ---HYVLY----------------SSDMKLRELERELFNEDL------------------ ----RWKY---------------------------------------------------- ---------------------------------------DNNEDETTPLID--------- ---------------------------------------LMNDGTVSPLSTNSY------ ---------------------------------------RPEATENTSLLSGETQT---- ---------------------------------------GETEDEQTALLG--------- ---------------------------------------AQLVTERTSLLSGETQT---- ---------------------------------------EQPVTERTSLLSGETQT---- ---------------------------------------QHRATEHTSLLSGETQT---- ---------------------------------------EQLVTERTSLLSGETQA---- ------------------------------------------------------------ ---------------------------------------YSPETEGSPLVSH-------- ---------------------------------------AQEADETTPLL---------- ------------------------------------------------------------ ---------------------------------------EGIQPTEDAVIPDENTPLL-- ---------------------------------------SNNNHENSVLL---------- ---------------------------------------RNNGGNTTAMTLESWSDIETR ---------------------------------------NNSKKQTNTFRLQPWSDIESN ---------------------------------------ESWDDIESRHSNRS------- ---------------------------------------RNAGANNTVMGLEPWTSA--- ---------------------------------------HNDSSENSALV---------- ---------------------------------------RKPVEPPISLTSWNHQ----- ---------------------------------------IQGESETSPLLQQDQQQ---- --------------------------------------GEGRKAETLPLLA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PVMNPIREEASSQFSADDISLSDSASKAGNSTMSPTFARPN -------------------MDREFSPSIVGSAPHAISPPFLAQQDSAITKPETPPGRRPN -------------------PQMNAIQEEDNSSPETPKLNDSDASSFSLSPSLFASPRPSS -------------------PQMNSIQEEDSPTTNKNNNNRLSTYGDIQMRPPKAKSRPTS -------------------PQMNAIQEEDNLSPETPKLNDSDASSFSLSPSFFASPRPSS -------------------LQMNAIQEEDNSSPETPKLNDSDASSFSLSTSLFASPRPSS ------------------------------------------------------------ -------------------PQMNAIQEEDNLSPETPKLNDSDASSFSLSPSLFASPRPSS -------------------PIMNSIEEEENTLEPPQPPGFHTPLAKSEPSG--ISPQPPQ ----------------------------------RPGRERADGGDHGRA--MKRIEEEPA -------------------PEKGHSLSDPQPIPPGHPLAGSGTPPRMNCGPLYNTPKRPS -------------------FETESAVSDTSDTPMPMSPSIHIEEAFVPNSSLNDTTEPFV -------------------PSLSSREDLDHN---SIATTPSTPQRMNCISTPSKTPQRPL -------------------DSNPRLMESPKLYSDPPDLKFLASANFSSDPFPSTCLSPTT -------------------FETESAVSDTSDTPMPMSPSIHIEESFIPNSSNDTMTEPFN -------------------HKHDNIHNHHMNVPNSININEPSKSTQMASSALGITPTTPK -------------------DNMGFDPPDFSRTFEELPVTPVQPQISVGDNFLNDASGPPM -------------------VNNDEASASRPRVPDMPSTPVRSESVDSTSPTFASLQNSPT -------------------LQDIFVNDIASEDNDVADLSHLASANFLSENLATPTFAGTN -------------------PDDISDGEQYGTTKTPPNLSFLQSANFSTDAAQSPIPRRYS -------------------PVMNSIKEEDSPTSPFQGNHAGPESPFNTTQSNSPFSRPNS -------------------LEDTTEESNYSSIPTINKKKERPSSTYSNLLLPAPVTSGSS SMYSQRDGNNSSSSLIYNPTFTFGGESRRNSAPPTSRNRSPVRPSSPRSSMMLDSPFNFS SFYSVQGGNDSSSSLVATKGFTFGSDYHTHSKLPPSRNRSPVRNRSPRNSLLFEAPFNFS LFYSAKEGNNSSSSIIYNPAFTFGNDNRRQSAPPPPRTRSPVRGISPRSSLTLDSPFNFT AFYSAADGNNSSSSLIYNPSFSFGSEGRRHSPPPTTRSKSPDRSASPRSSLILDSPFDFS LFYSAKEGNNSSSSIIYNPSFTFGNEGRRQSVPPPPRTRSPVRGISPRSSMTLDSPFNFT LFYSAKEGNNSSSSIIYNPSFTFGGENRRQSVPPPPRTRSPVRGISPRSSLILDSPFNFT ------------------------------------------------------------ LFYSAKEGNNSSSSIIYNPSFTFGNEGRRQSVPPPPRTRSPVRGISPRSSMTLDSPFNFT AFYASYEGNNSSSSLIYNPSFTFGGSQSSATAPPTTRTRSPTRSSSPRSSRPSSAPFNLA SLYSAVDASTSSSSLVAVPGFTFGAEQKRHS-PKPARSRSPSRGNAPRTSVVGDSPFNFA SLYSVPDANNSSGSLLCNQSFTFGTDSRRHSPPT-SRNRSPIRNRSPRSSVILDPPFNFT DYYNNSPRRYSNSSLTNSPRIGRAAISEDGQAPTGYRSSSPTRQSSPGSSPTKANPFNFQ SFYSNTDGNNSSNSLLMNPAFSFGQENRRQSLPPSSRTKSPVRNRSPRPSLVLDKPFNFS NGPNVNERRYSNSSLTNSPILQASPISEDGSVPLSSRSSSPTRSMSPSSSPTKSYPFNFQ DYYNNNPRRYSNSSLTNSPRMGRAAISEDGQAPTGYRSSSPTRQSSPGSSPTKANPFNFQ HGANST-RRYSNNSLLNSPVLQPPAIEEDGDSSPTGPPPSPPRSPSPSLSPTKSGPFNFK DYYSGYPRRYSNSSTSTTNTTNMPAISEDGQQSSSYRSSSPTRQTSPGSSPTKVAPFNFN GFLNQPQRSYSNSSSRPRPRSMFGPDSRSRNEQKASRSNSPKRSSSPRASSPTKQPFNFK GSFSPTYRKYSGNSLSNSPKLVASAIAEDDDVLASYRSSSPVRNASPSSSPSKSYPFNFQ NSSLASPQRTTFSNRTPRPKSVFDYFASTRSAPPSSRSSSPIRATSPSSSPSKSPPFNFQ SFYSSQDGNNSSSSIIYNPSFSFGQEGRRASAPPPLRSKSPKRSKSPKKRLSIIGPFNFN TNYSAGPSLAQLADLPTAPPPQWTGSPSRASSPLMPRSRSPMRSQSPNATTNTANPFNFE SAPITPPSSSSRASFRKGHRYKHSSVSMNFFQEPEVKIPLNISKSLPIPDSEDLIKNLPP SSALNSGPSSNSAMFRKGHRYKHSSVSMNFFQEPEVKEPLNIIKSLPVPDFKDLRNNLTP TSTLTPPSSAARTSFRKGHRYKHSSVSMNFFQEPEVKIPLNIAKSLPIPDLNDLMSNLPP PATLTPPSSASRASFRKGHRYKHSSVSMNFFQEPEVKIPLNIAKALPIPTFHDLIKNLMP TSTLTPPSSAARTSFRKGHRYKHSSVSMNFFQEPEVKIPLNIAKSLPIPDFNDLLSNLPP ASTLTPPSSAARTSFRKGHRYKHSSVSMNFFQEPEVKIPLNIAKSLPIPDLSDLMSNLPP ------------------------------------------------------------ TSTLTPPSSAARTSFRKGHRYKHSSVSMNFFQEPEVKIPLNIAKSLPIPDLNDLMSNLPP PPPSSPPPSASRTMFRKGHRYKHSSVSMNFFQEPEVKIPLSIAKSLPIPDLNDLIKNFSP SATL-QPPAGSRTAFRKGHRYKHSSVSMNFFPEPEARPALRLARALPVPDVRDIWHNLTP SSSLSSSNGSARTAFRKGHRYKHSSVSMNFFQEPEVKIPLNIAKSLPIPDFSDLKSNLPP SQDLGSNLSLPKPAHRKGHKYKHSSISMNLFQEPPPTQLSAIPDSYPIPNFNETLNSITP SSTLSAGSAT-RASFRKGHRYKHSSVSMNFFQEPEVKIPLNIAKALPIPDFADLRSNIPP PQELNASQTLQKPAHRKGHKYKHSSVSMNLFQEPPPNELLTIADLYPIPTFKESLASINS SQDLGSNLSLPKPAHRKGHKYKHSSISMNLFQEPPPTQLSAIPDLYPIPNFNETLNSITP PQEIGSNSSLQKPAHRKGHRYKHSSVSMNMFQEPPLKAPLSIADLYPIPNYKEAFASISK SQDLGSSQTLQKPAHRKGHKYKHSSISMNLFQEPPPVQLVAIPDSYPIPNYKETIASVTP PQDIGSNSSLVKPLHRKGHRYKHSSVSMNLFQEPLPLQQNLLPDSYPIPNLRESLASANG PQELNSGLSLQKPAHRKGHKYKHSSISMNLFQEPPPNKALNVPDLYPIPNFRELILSVKP PQELGSGPTLQKTAHRKGHKYKHSSVSMNLFQEPPPNQAM-IPDSHPIPTFKESVSSLTS SSSLGSAGNANRASFRKGHRYKHSSVSMNFFQEPEVKVPLNIAKALPIPDFRDFLSNLPP QTTYLSPPV--KPSQRRGHRYKHSSVSINFFEEPN-KAPLAIPKSHPIPNAKEALQSMSR KAHIQLIISLSQFILCIAVFYLGRKNWTFITFSHFIAYDIIGALVTILVENLSQFQVWST LTHIQISICIVELLISIFIFNLGHQKWNLGTLCHFLTYDVLGGIFAILTELLAKFEIWKT KAHMQLVIVALQILACLITFQIGHVYWNFITLSHFITYDIIGSLVIIFVENLSQFQVWFT KAHFQLAIAGLQCISCLITFQLGHSKWNFITLSHFITYDILGSLVIILVENLSQFEVWST KAYIQLSIAALQIFACLITFQVGHLYWSFITLSHFITYDIIGSLVIIFVENLSQFQVWFT KAHLQLSITALQVLACLITFQIGHLYWNFITLSHFITYDIIGSLVIIFVENLSLFQVWFT ------------------------------------------------------------ RAHIQLSIAALQITACLITFQVGHLYWSFITLSHFITYDIIGSLVIIFVENLSQFQVWFT RAHFQLFLTFIQLCMCLLVFQSGHHNWSFGTLSHFIAYDVIGSIAIIFVENLSQFXVWYT RHHVTLALVAAQAVACVLLLHRAERRWTFGTLAHFVLYDMLGTLTVVLVEVLPRFEVWGT DAYIKVAIALAQSLLCIFTFQVGQFYWNFITLSHFILYDILGSAAIILVQDLSQFEVWRT NQKLRFMWSGFHVGLSLIIFTIGFKFLPLSTLAHLVFYDSLGSLLIVFVDTMSNFDVWNK RGYVQLTIAGLQALTCLITFRLGHVKWSFITLSHFILYDIIGSFAIILVENLSQFQVWNT SQKSKLLWSFCHLALSLVVFLVGFKFLPLSTLAHLIFYDSLGTLVIVFVDIMSNFEVWNN NQKLRFMWSGFHVSLSLIIFTIGFKYLSLSTLAHLVFYDSLGSLLIVFVDTMSNFDVWNK SQKGRLAWSACHFAASLLVFYTGFNLVGLSTLAHLIFYDSLGSLFIVLVDVMANFEVWKK NQKFRFLWSICHLGLSIVIFGLGFKFLSLSTLAHLVFYDSLGSLLIVFVDAMSNFEVWNK EQKLKLSFAFSHFFMSGLVFFIGVKYQPFSTLAHLVFYDSLGSLLVASVDIMSNFEAWSK AQKFRLSWSVFHLVMALFIFVVGFKFLPFSTLAHLVFYDSLGSLVIVFVDIMSNFEVWNN HQKIKLAWSVCHLLLAVALFIVGFHFLALSTLAHLVVYDSLGSLVIVLVDVMSNFEVWSC KAYYHLGIMASELVMCITVFALGHTKWSFITLSHFIVYDIIGSLAILFAENLSQFEVWST DQRARMCWSGVHLLAAFVIFSLSSHDTALAALAHLVLYDALGATLTAAVDILGNFEVWKK GTITFPFGLNRVDVLLSFGLAVSLCFVGLDLVFHIIEESIVLLVETHSDIEQSIPHSHHV GTITLPFGLNRIDVLLSFAFAISICFAGLDLIFHVLEEIAVLFAEHHEEINQTIPHSHHH GTITFPFGLNRIDVLLSFALAVSLCFVGLDLLFHIVEEFIVLFVEDHNEINEQIPHSHFQ GTITFPFGLNRIDVLLSFALAISLCFVGLDLLFHILEELIVLFVEHHDEIASQIPHSHHS GTITFPFGLNRIDVLLSFALAVSLCFVGLDLLFHIIEEFIVLFVEDHDEINEQIPHSHIQ GTITFPFGLNRIDVLLSFALAVSLCFVGLDLLFHIVEELIVLFVEDHDEINEQIPHSHFQ ------------------------------------------------------------ GTITFPFGLNRIDVLLSFALAVSLCFVGLDLLFHIIEELIVLFVEDHDEINEQIPHSHIQ GTITYXFGLNRIEX---------------------------------------------- GTLTYPFGLKRLDVLLSFGFAVSLCFVGLDLVFHVLEELVVLFVEQHTDIVGSIPHSPHD GTIMFPFGLNRIDVLLSFASAISLCFVGLDLFFHVLEQIVVLFVEQHEDIVGNIPHTHFL SSLAYPFGLGRIEVLVGFALSTSLVMVGFDLFSHFIEEFIILWVSNHDDHEHSSHNVHAG GTITFPFGLNRMDVLLSFALAISLCFMGLDLFFHILEETIVLFVEMHQDIAPNIPHSHHT SSIAYPFGLGRLEVLVGFALSASLIMVGCDLISHSLEEFVISMVVEHDGEQHLSHHIHGH SSLAYPFGLGRIEVLVGFALSTSLVMVGFDLFSHFIEEFIILWVSNHVDHEHLSHNVHAT PSISFPFGLERLEVLVGFALSASLVMLGFDLFSHFFEELVLSLMSDHGEHDHLSHHVHEP SSIAYPFGLGRLEVLVAFALSTSLVMVGFDLFSHFIEEFIVLWVANHNDHEHSSHHVHAD SSIAYPFGLGRLEVLTGFALSASSVMVGCDLVSHFVEELVVSYVE---SEEHGSHHIHGP SSIAYPFGLGRLEVLVGFALSASLIMVGFDLVSHFIEEFIILMYIPHEGEQHLSHHIHGS SSIAYPFGLGRLEVLAGFALSTSLIMVGCDLISHFCEEFVIEWIVDQEAHQHSSHHIHGT GTITFPFGLNRIDVLLSFGLAISLCFVGLDLLFHIIEELIVLFVENHDELATHIPHSHGE SSIHHPFGLQRAEVLAGFALSVALIFMGGDLLSHSVETVVEVFYDHADDHGHRNTHGHGT GSDYSTWYLTLLVSIALSTLSLYKIYYSNTNSKLKTKNPLITISYGFYLMVYPVLANQFY QEQLISWYSVIILAATISFLSYSFIFK---TTQYKIKNPLITLSYLFYMSLYPILSHYHR NENIALWYGILVINLVLSTLSLYKTFYANKYSNLKTKNPIITITYTAYLFIYPLLLDLLS EGNLKLWYTILAMNLILSTLSLYKTFYANKNSKLKTKNPIVTITYTSYLCVYPILINWLS NENITLWYSILMINLVLSTLSLYKTFYANKYSNLKTKNPIITITYTAYLFIYPLLLDLLS NENITLWYGVLMVNLVLSTLSLYKTFYANKYSNLKTKNPIITITYTAYLFIYPLLLDLLS ------------------------------------------------------------ NENITLWYSILMINLVLSTLSLYKTFYANKYSNLKTKNPIITITYTAYLFIYPLLLDLLS ------------------------------------------------------------ ADALAEWYTVVALCGILSAAVLRTAFASREERRYKTKTPIITLAYTVYLLVFPVLSRYTE DSNFNLWYITLLVAITLSTFCLLYTFDSKKSSKFKTNNPLITIIYIVYLLLYPLVQSYTK NSNWFIYIVVLIVTMAVSLFSSNYILTYDRSVWKKNPTHLITLSYTLFLLVGPLIPQSLT SSDKRIWYLTLVPNLILSLLGLFKTFRSNAHTKFKAKIPLITCAYILYLALYPFIQIVTS LANWFVYELVLVITVIVTLITSRYILAYDRNIMAKNPTHFLTLTYSICLMTVPLLPSNIT DSNWLIYILVLIITMVVSLISSNYILTYDRSAWKKNPTHLITLSYTLFLLVGPLIPQSLT VGNIVAYEVVLLISLAVSLVSSNVILAYDRKAWRSYPTYLITITYIIFLIVVPIIPGSWV EGNWFAYMGILVVTMIVSLISSNYILTYDRDVWKKNPTHLITLTYTLFLIISPLVPQSLT NVNWFLYELVLLSVIAMTWLTSTIIFAHGTDIFAKNPIRLLTLLYSLFLFFVPMIPSSLK NANWFVYELVLLFTIAVTLISSNKVLAHDKNICTRNPTHLLTLIYSTFLVVVPLIPELIV IENMFAYEVSLCITIIFTLLTSRYIVASDRSVILKHPTHFLTLLFAIGLALLPVIPEAFT N-GLKLWYSTLLLNLLFSSLALYKIYYANTNSKLKTKNPIVTIAYTVYLFFYPLLVNRYA SVLSGTDLSITILALLVTVISAYGLKNHQRPSFLSNPSHLMTITSSLAIISYLLFPGSGS NFSDYIATIAIAFFILLHGLKIAEWTGVILLMGLSDASKFKSAIFEKLENLPEYKAKQDL GW-DMLATAVISSFIMSYGIQVAKWTSTILLMGFSDPSFVKSKIYDAILSLPLFKRTNDL SISDYLATLVISILILWHGLTIAQWTSTVLLMGFSNPTSIKNMIKDQIERLNEFKSRDDL NISDYLAAFSIAIFILIHGLTIVEWTSTILLMGFSDPVMVKGMIKEQIENLPEFKSRKDL SISDYLATLVISSLILWHGLTIARWTSTVLLMGFSNPTTIKNMIKDQIERLSEFKSRDDI SVSDYLATFVISILILWHGLTIARWTSTILLMGFSNPTNIKNMMKSQIEKLSEFKSRDDI ------------------------------------------------------------ SISDYMATLVISILILWHGLTIARWTSTVLLMGFSNPTIIKNVIKDQIERLNEFKSRDDI ------------------------------------------------------------ VG-DYVATVSIALFVMMYGLRVARWTGTVLLMGFSEPTIVKSRLGEMIEKLPQFRSNTDL VW-DYIATCAISIFIVSYGYTIAKWTSTILLMGFSETTVVKYKIKEMIEDLPQFRSNEDL SDLNEAATITVALLLCYNGWKLVKTLGGILLCSFPDYHMLKSRIIDQILSKDFFKQTEKF SS-DYVATSLLSIFIMSYGWTIAKWSSTILLMGFSDTTYVKSMIKESIEELPLFRANDDL SQIDEATTLVIALLLCYGGWRLVKILGGVLLLSYPDYHVLKASIIDKILSLDCYKNSEKL SDLNEAATITVALLLCYNGWKLVKTLGGILLCSFPDYHVLKSRIVDQILSKDFFKQTEKF QELQKCANILVACLLCYNGWNLVKFLGGTLLCAFPQNSVTKSNIMDQITGLDCFKHGQKL SELNEFATITVALLLCYNGWKLVKLLGGILLCSFPDYNVVRANITDQILSKDFFKQSEKF TKFNEMSTLVVAFTLCYAGWNVLKTLGGILLISFPDYNVLKASIIDKILSLPSFKKSGNF NESNDIATLVVSLSLVYTGWKLVKTLGGILLCSYPDYHVLKSNIMDSIMAVDAFKRSDKF SKISDASTLTIACLLCFTGWRLVSKLGSILLLSYPDYYNLKNEIIDGIYTIEGFKKSDKL NIADYVSACLFAGLIIIHGLTIVEWTSTILLMGFSNPTIIKSLLKERIESLSEFKSRNNL EVLDSIVTPIIALSMCYVGWQLAKSLGGMLIMSFP-----ISDIEQAILAENLVKSVSDV IVTKVNFNLYVVLMKVNMRGASNDEELHFRLAFDKCIKSILPGSETTIEIERLMKVLETR LFAKVNFQMFIVLIKIEMKNGSNDDELDLRLTIEKLVSDYVPNAETTIEIERMMRVLEEK IISKVNFTLYVVLIKITMKGGSNDDELMLRLAIDKCIQTSIPFCETTIDIDRIMKVLEER LIAKVDFNSYIALIKLTLKGGSNNEELLLRLAVDKCIRRNLNTVETTIEIDRIMKVIEPR VISKVNFTLYVVLIKITMKGGSDDDELMLRLAIDKCIQTSIPTCETTIDIDRIMKVLEER IISKVNFTLYVVLIKITMKGGSNDDELMLRLAVDKCIRTSIPSCEATIDIDRIMKVLEER -----------------------------------------------------MKVLEER VISKVNFTLYVVLIKITMKGGSNDDELMLRLAIDKCIQTSIPTCETTIDIDRIMKVLEER ------------------------------------------------------------ VLAKVHFEMFILLLKLNMKGGSDEEELDLRLAIDRCVKSVLPNVETTIEIERVMKVEATR LISKVNFDLFIVLMKLDMSGGSNDEELSLRLAIDKCVKQVLPNAETTIEIERIMKVESIR FITKFNYRLFVIGMKINMKGANSDEEVRMRFEINRIICNELVKPEITIDIDRFMKVLTER IIVKVNFEQYIVLLRLCMTGGSNDDELNLRISIDKCIRRTLKLVETTIEIDRIMKIESVR FISKFNYELYVIGLKITMKGGNPDDESKLRFEINRIIQNSVNKIEVTIDINRYMKILEER FITKFNYRLFVIGMKINMKGANSDEEVRMRFEINRIIYNELVKPEITIDIDRFMKVLTER FVTKFSYSLYVIGVSIEMKGANADDEVRMKFETNRIIENEVAKCEITIDIDRFMQILQER FITKFNYKLFVVGMKIEMKGANSDEEVRMRFEVNRIIRRELLTAETTIDIDRFMKILTER SFSKVNYQLYVVGVCVSMKGGSADDESRLLFEINRVIETTLARVETTISVERVMKILTER YITKFKYDFYVVGLKVVMKGADPDEESTLRYEVDRIIRNEITRIEITIDIDRFMKVLKER FITKFNHRLFVVGLKFSMIGASIDDESRFRFEINRLISRKIPQLELTIDITR-MQIINER LISKVNFQTYIVLMKISLKGGSNNEELALRLAIDKCINQVLPSAEATIDIDIVMKVLETR SFWQVHHNLCLVSMRIEMNQASSMEEQALKARAAEIAKNILVRWETTIDITR-MKVEKTR DAFLSDYEVLQHLSKMERQYHWDDESIA-EMSTKKRHMHRKRPYNNPALQRITRDVIDYL NAFMSDYETLQFLISLQNQHRWT--------SGSKSDRKHNKPYYHPELQTITRDTVRYI NAFLSDYEVLKFLTDLEKKHLWDQNSQV-ALKKNRSRGKENRPYNHPELQAITHGVVNFL DAFLSDYEVLQFLSKLERRHHWDDETTLANQKNKKMKKKIKRPYNHAELQNITRNTINYL NAFLSDYEVLKFLTDLEKKHLWDQKSLA-ALKKSRSKGKQNRPYNHPELQGITRNVVNYL NAFLCDYEVLEYLTDLEKKHLWDQESLA-ALKKNRSKGKNNRPYNHPELQGIIRNVVNYL NAFLSDYEVLKFLSDLEREHLWDEKSQA-ALKKNRSKGKQNRPYNHPELQGITRNVVNYL NAFLSDYEVLKFLTDLERKHLWDQKSQA-ALKKNRSKGKQNRPYNHPELQGITRNVVNYL ------------------------------------------------------------ DAFISDYEALQFMSHLQRKHQWVVDEDV---EMADDRRRKKKQYNHPELQAITKDVVNYL DAFLSDYEVLQFMSQLERKHYWSVDAAEDQQDGGRKSKKKKRPYNHPELQAITRDAISYL DSFLSNYEVLQHLQNIKKKYNWSFNPND-EKFMKNKKNKHHFTGCGINLEIITRDVLSCL DAFLSDYEVLQFLSQLERRHDWGLNQED----AGANKKRKRRPYNHPELQAITRDTIRYL DKFLCNFEVAEHLNSIKSKYNWTFKEEE----NDKKKNKKRFTACGLNLEEITRDLSSYL DSFLSNYEVLQHLQNIKKKYNWSFNPDD-EKFLKNKKNKHHFTGCGINLEIITRDVLSCL DSFLSNFEVEQHLKNIKRKYNWSFPGDEGTNNKRNVKQKPRFTECGIDLEIITRDVLLMM DSFLSNYEVTQHLESLKKKYHWTFEPNEDSKYNHKRKDKKYYTACGINLEIITKNVLLCL DAFLSDFEVFQHLRDLKKTYNWTFTPEE---EAQNNNKRKRFTAAGLDLEVVTRDITAYF DSFLSNYEVAEHLKEIKKKYNWTFTKEDQDLHNDKRKNKKRFAACGVNLEVITRDILSYV DKFLSNYEVLQHLKEIKEKNNWVFENDK----NDKKGHRRRGTAAGLDLEVITKDILSYA DAFLSDYEVLQFLSKLERKHNWIEDTND---ENNRKKHKKNHRYNHPELEFITKNTLSYL EALLSNFEVLAHVRDQERAR---------RMSQSASAASNQGTSHAENLETVIYELKDYL KMNKYDVAQEEEEDVKKM-------SPLCNLNDDKFTELVMRLNQYELFQAEKLQIVNQL TQRSTTAEDPEEPETSDKVPNNANKSTLLNLTTDQFSTLMQELNAFPLYKAEKLQIVNQL NINKNYINQEDENEEQENRTKDAEKSPISKMSDESFGELMDKLNFFKLFKAEKLQIVNQL SMNKNFIQQGEDDVDDPQANESNIKSAICNLNDERFTEFMQRLNEFDLFKVEKLQIVNDF SINKNFINQEDEGEERESGAKDAEKSGISKMSDESFAELMTKLNSFKLFKAEKLQIVNQL SINKNYINQEDEDEKKENGAEDAERSPISKMSNESFGELMTKLNSFKLFKAEKLQIVNQL SINKNYINQEDEGEERKSGVKDVEKSAISRMSDQSFGDLMTKLNSFKLFKAEKLQIVNQL SINKNYINQEDEGEDRGSDVKDAEKSGVSKMSDESFAELMTKLNSFKLFKAEKLQIVNQL ------------------------------------------------------------ TTNKNADPEEE---------QQAVKSGITRMNDEKFTTLMRTLNQFDLYKAEKLQLVNQL SMPKHILEEGA--------QPENEKSPITKLNDSSFTKLMNSLNEFALFKAEKLQIVNQL ENN----------------------ESSLIQSTKSFKQLMEFLNQFELMKVEKLQIVNSL SEAKGATETEE-------GSASDAKSPLTKLNDQKFTELMTRLNQFELFKAEKLQIVNQL ENN----------------------SSSMITTQEAFKELMIHLNCLDLMKVEKLQIVNSL ENN----------------------DSSLIQSQESFKQLMEFLNQFELMKVEKLQIVNSL KNNSSNINNAS-------------ATPDNAMTNTKFKELMQFLNKYELMKVEKLQIMNSL ENN----------------------ASNVIQSDESFKSLMEFLNTFELMKIEKLQIINSL SSN----------------------AAGSIPDEKAFTELMTFLNGFDLMKVEKLQIVNSL SNS----------------------ATASIDSTEKFSELVQFLNNYELMKVEKLQIVNSL DAD----------------------KKATITSSADFTALLQYLNQFDLVKVEKLQIVNSL SIDKNYLPQEEEQEEQDKALK---TSPLNRMNDERFTELVNQLNGFELFKAEKLQIVNQL NK-----------------------SPAASQSPEAITLFLQKINHLGLEKAERLQLINSV PVQMVHLYAIVEECDTRFTQEQIDALLQLVAEYV------------------------MA PTNLVHLYSIVEECESRLDEGQVTSLLECISRTCL-----------------------AP PANMVHFYSIVEECDSRFDEKTITEMLEIISGYS------------------------MK PTNMVHLYSIIEECDSRFNEEQIEQILSIVKSFS------------------------TV PANMVHLYSIVEECDARFDEKTIEEMLEIISAYA------------------------MT PANMVHLYSIVEECDARFDEKTIEEMLEIISSYA------------------------MK PANMVHLYSIVEECDARFDEKRIEEMLEIISGYA------------------------MA PANMVHLYSIVEECDARFDEKTIEEMLKIISGYA------------------------MT ------------------------------------------------------------ PVNIVHLYALVEECDSRFSEEQVSAIIDAITTACV-----------------------AR PTNMVHLYAIVEECDSRFSEDQVTKILEIVQESCM-----------------------MA PRSLVVLYALVEECEDRFGEETSESIIEKINELFPIQEEEEEEAGEGEGEGEEDAEINGL PTNLVHLFAIVEECDSRFPEEQSAQILEAVQLAFQSV---------------------AP PRSMVHLYALVEECDQRFNEETCEGIINKINHLFPIEEQEEEEEEEEEEQGEGEEKDD-- PRSLVVLYALVEECEDRFGEETSEKIIEKINELFPIEQEEEGE------DAQEDEEIN-- PRELVILTTLVEECEERFGEEGCEEIIAKIRQLFPVEEEEEEEEEEQQEEGVQEDAEM-- PRSLVVLYAIVEECEERLGEETSESIIAKINELFPIEQEEEEEGEEGEEEEQEEDVEMQT PRSMVHLYGLVEECDQRFDEETCESILAKINELMPVEADEEEEEEGEEEEAEE-----MR PRSMVTLYSIVEECDQRFDEQICNNILEKI------------------------------ PRTMVHLYALVEECDQRLSDEQSQGILDKIAELFPVEEDEEMEEAEE-----------QL PTNMVHLYAIVEECDSRFTEFQVEKLLSIIKEYI------------------------GV PTSIVSLYSLIEECDQRYNEDQCEEILDAIRTTLVSEEDAIAE---------------AS YYREVDLVQERVVPPGVVVPSSGAKEAVYTEKSNKDVIAKSKFVKLINELVDGISVRYPP FYREVDLVKEQVIPPSEVVLSSNAKEAAPQIESKK-----YELQDLLNKLAYGISLRTPE FYRQLDPVEEKIVPPNAIVISSDAKEATINKEAKQGVLSQ-RFMRFINELVDGISVRDPE YYREVDLVAEGVTPKNVTVSLQPKDNTN--VKVTPSRVIRKKTRELIAELVDGISVRNPH FYRQLDPVEEKIVPPNAIVISSEAKEATVNKEAKQGVLSQ-RVMKYINELVDGISVRDPD FYRQLDPVEEKIVPPNVTVTSSDAKEATVNKDAKQGVLSQ-RIMRYINELVDGISVRDPD FYRQVDPVVEKIVPPNAIVISSEAKEATVNNEAEQGVFSQ-KVLGFINELVDGISVRDPD FYRQLDPVEERIVPPNAIVVSSEAREANVNKEAKQGVLSQ-RVMRFINELVDGISVRDPD ------------------------------------------------------------ FYRECDIVAEGVVPPTGAIVSSDAYEAS------------KNVAEVLNQLLEGISVRTPG FYRTADLVEESVIPPTGVIVSSAAREAAPSTDSNS-----HTATELVNQLVDGISVRSPL LTPIVTTGAIIAIPTNQMIFNRSFYEDDENVVPIPGTVTPATELETLNRIIDGISVRSTQ FYRSVELVSEAVIPPTGSIIS-----SEAKAAPSHFQKSSHNAAEIINKILDGISVRSPA -MFARSSVHYGASLAVGAFLIRRFYEDESDVIPVPGTITPGTEIEALNKLVDGISVRSTS ----------MTIPTNQMIFNRSFYEDDENVVPIPGTVTPATELESLNRIIDGISVRSTP ---MFKFVGYATPIVAAAAVSRRFYEDDVTAAHIPGTVVAASEIASLNRIVDGISVRSTP IYHSHQHIDPSETMFGIRLLTRSFYEDEENVVPIPGTVIPASELESLNRIIDGISVRSSK HLSSFMSRPVSAAVAGAAATCRRFYEDEASVNPVPGTTIPETQQEILRSVINGVTVRSIS MFSKQALRVTIPVLASGIIISRRFYEDETDVVPVPGTVTPGTELEALNRLIDGISVRSPE HTTEMSFLRIGLSVTGASLMHRRFYDDENAVNPVPGTVTKGTELEAMSKLVDGASVRTSS YYRQVDLINELVVTKESIITPRNIAQEEYDDSPSKGRSKV---VKLINRIIDGVSVRCPP FFKTATPLSFAAIAVSAPVAFRSIYDNDEEIAPVPGTVETREGDIEKVENVGGVTIKSPK YMVDFFRRRRTNLAERLDRTSEKLEKASNRYYRSERKITSTIAGLKAERKEFIPGLTYTA PLINFFGAVRGKLSNGLEFVENKIDRSSQAYYDKERKVTSAIADLHSDPKELLPGFTYIL YMKKFFNERRLQLSAKWDKAAKKIDEAVGKYYAREKSFTSTIASLHTEPEELIPGISSTL YLTDYLKKERESLSKTLNSTLEKIDQVTSKYYNKEVLMTRGLNCVYTDSKSLLPGLTYIG YLKRFFNERRKQFSAKWDKVTNKIDDIAGRYYAREESFTSTIASLHTDPNELIPGLLSIL YLKKFFNEKRQKLSVKWDKTTRKVDNVVGKYYAREKSFTSTIGNLHTDPKELIPGLSSTL YLKKFFNERRKQFSTKWNKVTTKVDDVVGTYYAREKSFTSAISSLHTDPKELIPGVSSIL YLKRFFNERRKQFSTKLDKVTRKVDNVVGRYYAREQNFTSTIASLHTDPNELIPGFSSIL ------------------------------------------------------------ WLVNFFQKSRTVVTAGAERAAHQIETVSRRYYEKERRITSTVAALHSNPRELLPGFGAVA YLTSFFNSIRNSLSSLVNDTCDSIDSASRKYYKEERRLTTTIASLHSDPRELLPGFTYTA STENLFKSVRKFTESTVDSLNSWADQKYHQYNKTERSVTDTVSSLHSKSEDLLPNSLYIL YLNDFFSLWRLRLSNTINSACETIDEKSRKYYHHERRLTSTIANLHSDPRELLPGMTYTL TLESYFRAIRESAVQGINLVQHYMNQGYTKYNETERQVTDTMAELHYKPEDLLPSTLYIV STENLFKSVRKFTESTVDSLRFWADQKYHQYNKTERSVTDTVSSLHNKSEDLLPNSLYIL TTEIFFKTIRFHAVGNWTRFNHWVNQKYTTFNDTERYVASTVSDLHYKREDLLPNGIYVV ATENLFKSAREYTESTFDNLSNWANSKYATYNETERQVTNTVSGLHNKTEDLLPNSLYIL SFESAFRSLRETVTRAVTATQDYLDEGKVKMYQAERDVTGTVSALHDRREDLLPNSIYIV AVESVFKSARETSQNVLAQVQLYVNDGYSKYYETERHVTSTVGELHAKSEDLLPNSIYIV TLESAIKSTRLFAAQSAENISSYVDEAYAKYHSAEKSITSTASKLHDRSEDLLPNSIYIV YLLNFFNLTGYRLNNRYNNVYNKVEDVSSRYYRMEKKVTSRIAGLHSDRDELLKGFAFTL ALESNIKVAREWFADKVQQGNQYIDEAFNKYLAVENSVTKTVADLKSPQEDILPAGIYIT VSFMTGSVLTRNRNFVYRFFTPIILGTTCLAFVLPGTFNNVKSLCYDIEKHFPSFVENQD VASMSGSILTRNRNIFLRGVTPVVFGISCFSYVLPTTYRNTKRLAYDIEKRFPVFVSRQD VAFMTGSVLTRRRTWLLRATMPIILGSCCFAYVMPSTFNNVMGLVHDLEKNFPNFVQRQD VAFMAGSIAVRNRNIALRMGVPILLSSVCFSYALPNTFETIKLILHEKEEDFPVFTERQD VASMTGSVLARRRTWLLRATMPIILGSCCFAYAMPTTFRNTMGLIHNLEMNFPHFTERQD VAFMAGSVLTRKRTWLLRATMPFVLGSCCFAYAMPNTFKNTMDLIHDLEKNFPNLVQRQD VAFMTGSVLTRRRTWILRATMPFILGSCCFAYVMPSTFKNTMGLAHDIEMNFPRFVQRQD VAFMTGSVLTRRKTWLLRATMPIILGSCCFAYAMPTTFRNTMDLIHDLEMNFPRFVERQD ------------------------------------------------------------ VAYFSGSVLTRKRGIVLRVCAPLALGLGAFSYFLPTTFRNTKSLCYDLEKRFPQFVAQQD VAAMSGSVLTRNKSILLRLTTPLLFGAVCFSYVLPSTFSNVAGLAHDMERNFPRLTETQD VAVLSGTIAGRTRGVVAKITLPTVFGLTAFKYFLPQTFNNTAGFFWKLEKEAPQIAAQQE VAAMSGSILTRNKNILARIAAPVILGVGCFSYVLPITSSNTFSLLFDLEQQVPRFAHSQL IATMSGNIMARQRGLIAKTTFPLVLGLASFRYFLPQTFNNVSGFVWNLEKRLPDLAEQQQ VAVLSGTIAGRTRGVLAKITLPTVFGLTAFKYFLPQTFNNTAGFFWKLEKEVPQIAAQQE IAILSGTIAARPRGILAKVAFPTIFGLAAFKYFLPKTFENTREFAWSLEQKLPEVARQQE VAVLTGTIAARTRGVIAKAVFPTVFGLASFKYFLPKTFENTTGFVWKLEEEVPQIAAHQK IASLSGNIMARQRGVLAKVFFPVGLGLASFKYFLPQTFSNTMGFLWKVEQRMPALATTQV IATLSANIAARQRGIIAKATFPVAFGLAAFKYFLPQTFANTTGFLWKLEKNLPQIAQQQE VATLSGNIAARQRGILAKMTFPVVFGLAAFRYFLPQTFSNTAFFAWKLEQELPQIAKQQS VSGMTGSILFRRRNILARFTMPIVFALACFSYALPTTYDNTMDLIHDVEESFPNFVAKQD VAALSGSILTRNRNILFRSAIPLAFGVAAFSYFLPQTAHNTGALVWKYEQKVPEVAKAHV KIVFKINVGIGKTISVLEHTFSTIGKGVSRTQAALQEWTGLNVGQVVALAMASSAVALNC KLYNATMKAACNTAYYTKNVAATVKRGYERTNKAIKEWTGLNVVLLATALLLPFSSAVEC NVWGEIKRLSNTSVQYYHDARKWLNQDVEKTGDAIKDWTGVNV----------------- RIVDQVKELPISTKTLINRTTEFISRPFSTIQQYFKTIEK---ASLAVLILTPYVDALQC RVWKETKRLSTASVQYYYDAKKWLNKDVEKTGNAIKNWTGVNVTWICGFIIITVVQALSC HVWGEIKRLSNASIKYYSDAKKWLEKDVEKTGDTIKDWTGVNVNWICGFVTIVVVQALSC HLWQEIKRLSNASMQYYCDAKRWFNKDVEKTGDAIKDWTGINVTWVCILLAVTVVQALSC HVWKEIKRFSTASVQCYYDARKWLNKDVEKTGDSIKDWTGINVTWICSFVVITAVQALSC -------------------------------------------VFTVAVGFAPCINAIKC RLAAGTKRAVCGTVHTTVSAYNATHRACRKVTKVFRDWTGLNLRCVLLTGLFNIAAGLKC KIYSSSKTAVTTTTRSICRLTAAASTVYSKTTNTLKEWTGLNM----------------- SAYNSAVGLVHSIEETTESGKKSIENGTKSLKKSIANITGLNLMILASLLFATAALAFDC ALYNSCKNTVHKTAIAAERARNSVTGSFTKTANLIKEWTGLNVGQIFTLTLASFCSAFVC LALAKADQFVQGVEKSSQRNQKRLEDSANSLRKSIAQVTGLNIYLISAALLIGGVSGIDC SAYNSAVGLVHSIEETTESGKKSIENGTKSLKKSIANITGLNLMILASLLFVTVALAFDC NAYHSAVGLAKAIEEGTEHSVKRVEEGAATVRRSIAGITGLNLNRLLIFILALAVRALDC FAYNSALDLAHKIEENTETGKKSIENSVHSLRKSIADITGLNIMIFTTLLFITAVSAIDC AALEKTERLVNQVEQTAVSGQEKVSGSMESLRKKIITATGLNLQTVAALLLAGATTAFDC YVFNKTGELVQKIEQTSESSKKSIESLIHSLKHSIADVTGLNIWAIAGLILLAQAAAFDC AAVDSAVGMVNSVERKTKDGQTYIGNSVESLKKSIADVTGVDIMWFPILTLVATAVALDC VIVAKGRIGIDHTIMTYE----IIKDKLSSVNNFIKGHINFN-TWV---LVLPLVNALKC DAKESVDSFAKNVRKALDDGKTSLESGVHSTRKFIADSTGLQL-MKSAIIMAVAVAAASC KNHNLSNYNVANKDILLKNELDTPPSKTSEMWYLAPCEDGRPSECSSDDLMCAIRHVKVD SKNELNKYRVNEFSIGGVSVQDTPPSETKESWWLNICDEHSPDQCNVKDIFCGVTSVALG -----------------------------------------MPD---------------N SKHDLKKYKIDKYASLGQIERDTPPSKTTEKWWVNPCEESAPSLCYQDDVICGLTEVLLG EKHDLKKYQVGKFSSLTSTERDTPPSTTIEKWWINVCEEHVPEECKKNDMLCGLTDVILG EKHDLKKYQVGQFSSLTSTERDTPPSRTIEKWWVNICEERVPQGCKKDDMLCGLTDVIMS EKHDLKKYQVAQYSLLGTTERDTPPSKTNEKWWVNVCEEHAPEGCKKDDMLCGLTDVSLG EKHDLKKYQVGKFSSLTSAERDTPPSTTIERWWINVCEEHAPEGCKKNDMLCGLTEVALG NSDDLKRYGISKNTLSSSLQRDTPPSKTAEQWFLGICEEDFVPDCNSKDILCGTTRVALD ADSKLSRYKVSQHAAKGKFTESTPPSETTDFWWINLCEEHEPDKCKDDAMFCHRQQVKLD ------------------------------------------------------------ SDKELERYNFESIKGVHSYTKNTPPSQTNVTWNVGICQPIAIKDCPANSDICGVTSILRD SEHGLKKFNVDKYSQLTSSIRKTPPSQTEEQWWINICREHDPSPCQSSDVLCGMTKVKLD GVKELKEYDFESIKGIHSVTKDTPPTQTNVTWYIGICDTISIDHCPKNSDLCGITLINLN SDKEIKRYNFESIKGVHSYTKNTPPSQTNITWSVGICQPIVIKDCPANSDICGVTSILRD SSKELQQYNLESVKGTYSISKSTPPSKTNITWSIGICEPIDVADCPQNSDVCGITSILIG SANELKPYNLESIKGIYSFSKNTPPSTTNLTWNVGICEPVNIQDCPQDSDICGVTTIQLD SAKQLEAYDFKSIEGVYSAQHDTPPSKTQLTWSIGVCKNVSIDQCPKNSDVCGLTRIEAD SAKELEHYNFELLKGIHLVTKDTPPSQTNLTWYFGICEPIKLDACPQNLDVCGITSIILS SAKDLDSYNFALLQGTHAVEKDTPPSTTKTTWYFGICESVSAPACPKNVDICGVTEVKVD ANNRLRKYHIDKHSAKKSVARDTPPSKTTEKWYVNPCEEHAYDGCDKSDDICGIVMVDLN QFTVSKNYDLSAISGPKSVEIETPPSKRKMEFVLDPCASLQPEQCPDNTIVCGLGYILLE GSDHLTQKLDVHKSAKYEVEEVESGFDIRFLGVKWGSNTIDATLSYSCTNLKTDELVTTI KESIVTKVMDFTSSVALEVKETAEALSIRLSGAAWGSHILNADIYLQCQEKGSGSLTESS KDAITTQIIDFNRNIGFSVEETENALSLSLKGATWGSNVIDAVLQFQCDNMKEDEMVSTT KDPLVTQVINFSKKLAYSVEEVDDTLVLSLKSTKWGSNTLDARLEFSCDKLETDELSKTT KDAITTQIIDFDKNIGFNVEETESALTLTLKGATWGANSFDAKLEFQCDNMKQDELTSHT KNPITTQIIDFNKNIAYSIEETESALILTLKGATWGSNVMDAKLEFQCDNMKEDELVDHT KDTVTTQIIDFDKNIGFNVEDTENALILTLVGANWGSNSIDAKLKFQCDNMKKDELTGHT KDAITTQIIDFDKNIAFNVEEVESALILTLKGAKWGSNSFDAKLEFQCDNMKQDELTSHT KNPILTQVIDFPQNIKYNVEQQENGFTFEIN---------------RC------------ GKEYVTQVFDVPRNQEVDVEELRDGFQVSFTG-KWGERERKVKVRYTCDDKAEDEVSAEG ------------------------------------------------------------ EKPVVSEVVSFKSDLQKAYESSDNGIKVIYKGANWGDVLVNAELNFQCKDSQNNEFTLDQ NE-ILTQLIDFPDTLEQSANMNDQGLVVDFKGAQWGDNVIDAHITFICSTPRDHIVT--- KDAVVSEIVGFNTNLQKQYDNNEDGITIVYKGANWGDNLVDAELRFVCKDKDLDKFQLHQ EKPVVSEVVSFTSDLQKTFESSDNGIKVIYKGANWGDALVNAELNFQCRESQNNEFILDQ KSPVVSEIIGFNSNVQKEYAEGDGGIIVKDKAVNWGDSLIDAEIHFICKNAKENDLKLDK AKPIVSEVIPFSGTLQKKYETSDNGVKVIYNGAHWGDALVNAELNFICKESTDKSLTLEQ GQTLLAEIVGFNSNLQKTYANSESGVTIEYKGANWGTNLVDAKVRFVCDASGDNKLTISQ KNRVILEIVSFNTNLQKTYEIDSTGIAISYTGATWGDNSINAALRFVCNEHILDKFKLDS KDYIVTQVVGFNSNLEKKYSKNENGIKISYKGANWGSSLVNAEVYYICDKDGDDTFTVES KDPFVIKRIEATDMASFTATEESNALVLRYTGISWGQNMVAANIRYFCKNSNEDEITSSI KDFVLSEVMPFGNGPAPQYPEGTEGLSTSY-GNPWGSEKLDIDVNYICDKEEGPKLENVG WNSEYVLIEMSGPSGCKRDDNGNNKTS-WFTWLFVYAILFTVIYLMVVSYLNTKGFRNEF WTDDQVKLVFSGPFGCLKKDNKDDKNGGWLVWLFMYATIFALIYLVVTSYMNTRNFREEF WADKRIQLTIKGPSGCLKSDKKKDKPSSWFTWLFLYGLLFTLIYLMVVSYLNTRGFRAEF WQNNQILLSIKGPSGCLKNDGNKNQSSGWFLWLVLYALLFTVICLVVVSYMNTRGFRTEF WADKSIQLTLKGPSGCLKSDKKNDKAGGWFTWLFLYALLFTLIYLMVVSFLNTRGFRAEF WADKTIQLTLKGPSGCLKSDKKKDKSSGWFTWLFLYALLFTLIYLMVVSFLNTRGFRAEF WTDKTIQLTIKGPSGCLKSDKKKDKSSGWFTWLFLYALLFTLIYLMVVSFLNTRGFRAEF WADKSIQLSLKGPSGCLKSDKKKDKSGGWFTWLFLYALLFTLIYLMVVSFLNTRGFRAEF ------------------------------------------------------------ GAHTTVEVALRGPSGCIQA--TE-KSSGWITWLVIYAVLLTLIYLLAKSYMSVGHFREEF ------------------------------------------------------------ WDGTNLKLSMKTKAACITSDKKKEESWGWFTWIFIFLVLFLSIYIIGGAWFQYNKFQSEV WQDKQINVIVEGSAGCVKDDPDEGSSVGWFLWLVTYALLFALIYLLATSYMSTRGFREEF WDDKRLKVSVKTKAACITDDKKKDESWGWFTWIFIFLVLFLSIYIVGGAWFQYSKFQSEV WDGTNLKLSMKTKAACITSDKKKEESWGWFTWIFIFLVLFLSIYIIGGAWFQYNKFQSEV WDGQSVKLSFKSKAACITSDKKKNELWGWFTWIFIFLVLFLSI----------------- WDGTNLKLSMKNKAACITSDKKKPESWGWFTWIFIFLVLFLSIYIVGGAWFQYNKFQSEV WDGKVFIGEFRSAAACAKGKGKKPESWGWFTWIFIFMVLFLSIYIIGGAWFQYNRFASEV WDGKKLKASMYSKAACITSDKLKKESWGWFTWIFIFLVLFLSIYIVGGAWFQYNKFSSEV WDDEMLFAQVKSKAACVTSDKKKKESWGWFTWIFIFMVLFLSIYIIGGAWFQYNKFQSEV WANNDISIIIKGPSGCKKDELEDEESSGWFTWLFIYAIFFTVVYLVVTSYTQTRGFRHDF LGLNNYEINWKTPAACINDPKQPDPSWGWFTWLFIIIVLGVAVYIIGNAWINYDRYGNDL VERGTEFTSLPTFVKEVVTKTLGASRGGYSAV---------------------------- VDRSTTFTNLPQFAKEVAGKIVNSQRGGYSAV---------------------------- TQRSTQFTSLPEFCREVVSKILGSQRGGYSAV---------------------------- IERATELTSLPQFTKEIVNKVLGARRTGYSAV---------------------------- IQRSTQFTSLPEFCKEVVSRILGAQRGGYSAV---------------------------- IQRSTQFTSLPEFCREVVSRILGTQRGGYSAV---------------------------- IQRSTQFTSLPEFCREVVSKILGTQRGGYSAV---------------------------- IQRCTLFTSLPEFCREVVTRILGTQRGGYSAV---------------------------- ---------------------------QMGLX---------------------------- VERSTNLSSLPEFAKEVMGKIQGGTKGEFSTV---------------------------- ------------------------------------------------------------ VENFIELKGLPSFGKEIIEKFTGSNRGEYSAV---------------------------- VERSTSLGSLPQFAREVASKVLGSQRGGYSAV---------------------------- LENFVSLKGLPSFVREIIEKFTGSNRGEYSAV---------------------------- VENFIELKGLPSFGKEIIEKFTGSNRGEYSAV---------------------------- ------------------------------------------------------------ VENFIELKGLPSFSKEIIEKFTGSNRGEYSAV---------------------------- LENFVDLRGLPAFIREIVEKISGSSRGEYSAV---------------------------- LDNFVELKGIPAFSREIIEKFTSSNRGEYSAV---------------------------- LENFVDLRGLPSFIREIIEKVTGSNRGEYSAV---------------------------- VERAKQFTSLPAFVREVVSKVLGAERGGYSAV---------------------------- LPHADSLRDVPYLIRDLIAKVVGSSRTGYSAV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MSGIELHKSSNYHQVHTTLDRSLSYRNTTSTLVAHSLSTPHRCLFG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MNAYD---------GNS-TVPD---------------RRAEKLAQSR ------------------------------------------------------------ --------MYSESVMNWFEDHL-----PTFDVDVD---------------KHSRTLR--- TTTQNPTDGSISKFLRWLGSKL-----PSFDEQAD---------------KEQRLAL--- --------MNLKSIVSWFKEHL-----PSFDVDVD---------------KHFRTLR--- --------MGLKSITSWLKEHL-----PTFDVDVD---------------KHFRTLR--- --------MNSKSIISWFKEHL-----PTFDVDVD---------------KHFRTLR--- ------------------------------------------------------------ ------------------------------------------------------------ ------------MGGAWQE--------AVV-RSIG---------------AADERM---- ------------------------------------------------------------ --------MNATILDYFHY--------PNG--KTK-------------EYSRLRNYI--- ARIYYLFSFDSQLEQPFPYMSETG---EFV-NLHSDSITSWLPSFSKASDKELRKIL--- ------------------------------------------------------------ --------MNTTILDYFHY--------PNG-KTKE-------------Y-SRLRNYI--- -----------MFNETLPESWTHYFHFPKG-KTKE-------------Y-SELRNYT--- ----------MNITEYFHY--------PTK-KTKE-------------S-SELRKNT--- ----------MDFLQYFHY--------PDG-KTKE-------------Y-VQFRQCI--- -----------SVLDYFHY--------PIG-KSKN-------------Y-KNLRKMT--- -------MRVAQFTKSFYNLIDFEFHYPDQKSPQY---------------KDYRQNT--- MSLSLITESLIQLFNDYSVSSNSE---CNE-LDRD---------------KCNKKLMGLK ----MNHTDMTLECETWSKSLMDHLGLGFNWHMDN---------KPAPAKKAFRKLV--- IADLYSRACFTCALIIICVMIPSYNR-----VT--------------------------- ------------------------------------------------------------ -VRKYSQICLLLSFIIICIIIPLLNC-----LL--------------------------- -TAKYTNSCLVITMCIICVLLPLWTT-----LS--------------------------- -VRKYSQICLLISFIIICVIIPLMNY-----LL--------------------------- -VRKYSQICLLISFIIICVVIPSMNC-----LL--------------------------- -VRKYSQICLLISFVIICVIIPLMNC-----LV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -VRLSGWASLALALGLVCVVVPVVNY-----MR--------------------------- ------------------------------------------------------------ -TSKYGNITTLLLFLFIISIPIYKYF-----IIHNYHHRFKSNIIRSFNR---------- -VRRSGLAAGWIAFITLCIALPLWNY-----LS--------------------------- -MDRFE-----------SLINLLDYF---------------------------------- -TSKYGNITTFLLLLFIISIPIYKYC-----IIHNYHHRFKSNIIRSFNR---------- -TYKYGIITTVLLCFIILFIPIYHYI-----ILHNYRLKFHFLKRFYT------------ -TAKYGDIATLLLLVIIISIPIYNYL-----VIHNFHQRFKSNFIRSFNS---------- -TVKYGQIMEVVLLVVICYIPLQNYL-----LAKKRTFLPRLHL---------------- -TARYGQITTFILIAFLILIPIHRYL-----IKNGYTLTNKLQILRSVNRRLNKY----- -TDKYGAITTGFLVAFLLFIPFANTL-----IRHGY------------------------ -VQKYSNITLIISLFLICLVLPFYHK-----LT--------------------------- -TRQWGLYSLAVTAIFILGAYALTNVAVDAIVIRRLRKY--------------------- -----------------LSQRYFQVMHYFRHHFVARHA---------------WIHRLR- ------------------------------------------------------------ -----------------ITNKFFKICHHLKHHVFNRRS---------------WVHKTH- -----------------LTGRGFQISHRIKHHILGRNS---------------FLHKSK- -----------------LTDKFFKICHHLKHHVFNRRS---------------WVHKTH- -----------------LTNKFFKICHHLKHHVFNRRS---------------WIHKTH- -----------------LTDKFFKICHHLKHHVFNRRS---------------WIHKTH- ------------------------------------------------------------ ------------------------------------------------------------ -----------------LNPWVFRVMHHWRHHVMRRHG---------------AMCRK-- ------------------------------------------------------------ -----------------KLDHYTQHEHHPNCQTATFKD----RFYTYIAQLLKSIVFNI- -----------------LKRWFFKLRHHLRHDIFRKYR---------------WLHGSP- -----------------HYPTQKSKEYSKYRQELTNKY---------------------- -----------------KLDHYILHEHHPDCQTATFKD----RFFTYVAQLLKSIVFSI- -----------------RLNHYIKHDHKPNCAQATFRD----RFNSRAAQAVKSFAFYI- -----------------KLDHYISHEHHPNCRTASWRD----RLLTNVAQVLKRIVFNI- -----------------LGSINVALDHRIRHYEATNKH------------VRRWICQALK -----------------IYPSDDLHESHRQYYKRLRSR--------LALRAKTWIFNFS- -----------------FRGRSRHLFRGFSSWINRFIP------RDHQGRTLTWVGFVLE -----------------LTNSFFKVQHIIRHHLLYKHF-------------NWLIHHTL- -----------------ARPPGTRVQFFRQGLRLRLMI---------------------- ---------------------------------VYHNKSLQ-QCIFWCSFVGIF------ ------------------------------------------------------------ ---------------------------------MYHNQSLQ-LCLACFVFTTIF------ ---------------------------------LYHNKSFK-ICLFWFIITAVC------ ---------------------------------MYHKQSLQ-LCLICFVFTSFF------ ---------------------------------IYHKQSLQ-LCLVCLVFTSIF------ ---------------------------------IYHNQSLQ-LCSLCFLFTSIF------ ---------------------------------MYHNQSLQ-LCLMCFVFTSIF------ ------------------------------------------------------------ ---------------------------------LVQQRTLW-LALLWCMLGGAC------ ------------------------------------------------------------ ---------------------------------TLRSSTII-QLLFWITFLTSL------ ---------------------------------LYHSQTLK-ICTFWSALSIAC------ ------------------------------------------GNITTVILVVFL------ ---------------------------------TLRSSTII-QLLFWITFLTSL------ ---------------------------------LLHLSTIT-QLIFWTAFLSTM------ ---------------------------------TLHSSTII-QLLFWTAFLGTL------ NLAYGI---------------------------YLNSTTLF-QIVFWLALFSFM------ ----------------------------------YHASTIF-QLAFWLTVLSSL------ SIRIGAFKL------------------------YLHGSTIV-QVFFWLFVLSVL------ ---------------------------------FYHNQSLQ-ICLFWSILISFI------ ------------------------------------------PLLLTIVTVCSL------ -TLHGSQGNF-FIVV---------KKLGRLAVALMPPLLFLTLRP--SPLP-----KTLY ----------------------------------MPALLFLTTRP--SPLP-----HVLY -IVQGVNRDL-LEIT---------KRMGRISVALMPPLLFLTLRP--SPLP-----HTLY -STYDAKRDL-LQIT---------KRMGRVAVAMMPPLLFLSLRP--SPLP-----RVLY -VIQGANGDL-LEIT---------KRMGRISVALMPPLLFLTLRP--SPLP-----HTLY -VFQGANRDL-LEIT---------KRMGRISVALMPPLLFLTLRP--SPLP-----HTLY -VFQGANRDL-LEIT---------KRMGRISVALMPPLLFLTLRP--SPLP-----HTLY -VVQGANGDL-LEIT---------KRMGRISVALMPPLLFLTLRP--SPLP-----HTLY ------------------------------------------------------------ --AVVGSADV-VVVT---------KRLGRVAAAFMPALFLLTLRP--SPLP-----YTLY ----------------------------------MPPLLFLTLRP--TPLP-----HTLY SLVDIYNGDL-IFLA---------KRLGRIPANCLPTILFLTLRP--SPLP-----HTLY -TFVAASGDL-LQIT---------KRLGKVAVALMPPLLFLTLRP--SPLP-----YTLY --------------------------------IAIPIQKLLTVKG--YTFSRI---KLFK SLIDLYNGDL-IFLA---------KRLGRIPANCLPTILFLTLRP--SPLP-----HTLY SLVDIYHGDL-IFLA---------KRLGRVAANCMPTVLFLTLRP--SPLP-----NILY SLIDINNGDL-IYLA---------KRVGRLPVNCLPAVLFLTLRP--SPLP-----NTLY ALTDIHRGDL-IFVA---------KRLGRLSVVSLPTVLFLTLRP--SPLP-----NTLY SLTDIHNGDL-LFLA---------ARLGRVAAVCLPTILFLTLRP--SPLP-----NTLY SLSELYHGDL-IFLA---------KRLGRIATVCLPTVLFLTLRP--SPLP-----NTLY -TIYNTNWDF-KEIT---------KRCGRISVSLLPIVLMLSLRP--SPLPKKL--NLLY ---VQTYQDF-IFLT---------KRLGRVSAALYPAMLFLALRP--SPLP-----RTFY LTLLPFHKWIGRIVVLAAFLHSVFYAYV------M----CANKVLLEKMRKPA--NLY-- LALLPLHKWISRIVVFQSLLHTILYTVY-----------YARIGALAKLKKLA--NIW-- LALLPLHKWISRIVVLESVLHTWFYLYY------M----YINGALYVKMKKLP--NIY-- LSLLPIHKWISRIVVLGSLLHTVFYIIY------M----HKRNVLWTKIKKLP--NIY-- LALLPLHKWISRIVVLESILHTWFYLYY------M----YINDTLYVKMRKLP--NIY-- LALLPLHKWISRIVVLESVLHTWFYLYY------M----YINDALYVKMRKLP--NIY-- LALLPVHKWISRIVVLESVLHTWFYLYY------M----YINGMLYVKMRKLP--NIY-- LALLPLHKWISRIVVLESVLHTWFYLYY------M----YINDTLYVKMKKLP--NIY-- ------------------------------------------------------------ LSLLPMHKWLGRVVVLQATVHSALYTWY-----------FATSGKMAKMKKTA--NWM-- LTLLPIHKWISRIVILQSLLHTFFYTWY-----------FATTNKMFKILKPA--NMW-- LTLIPIHKWLSRLIIIQSVIHTVLYLGY-----------FQKTNTTQKTFKPE--NNY-- LSLIPIHKWISRIVVSLSFLHSVLYTWY-----------FIESRAIKKITKLA--NLY-- KTNVGLNKWIERD--------------------------EDENYRLNKLKRFI------- LTLIPIHKWLSRLIIIQSVMHTVLYLGY-----------FKKTDTMKKTFKLE--NNY-- LTLIPIHKWLSRLIVLQSVLHTLIYLAY-----------FDFSHTWQKTWKKE--NVY-- LTLIPIHKWLSRLIIIQSIIHTVLYIGY-----------YDFKNTMDKAWKLE--NVY-- LSLLPIHKWLSRVVVLSAVVHTALYLGF-----------FQKSDTWFKAWKTE--NLY-- LTLIPIHKWLSRMVILQLVLHVSIYCGY------F----HKNGTWKKALKTE---NIY-- LALLPIHKWLSRLIVLQTVLHVILYCGF-----------FYRNHTWGKAIKPE--NLY-- LSLLPLHKWISRILIFQATLHSALYTWW------Y----YENGKLKLKLLKLT--NIY-- LALLPVHKWLSRIVVLTTVLHSIFYAYI------Y----YSTGVLGKKMAEIE--NIY-- --GLIAMVLFVLIVVTSLAPIRRRAFRVFYTVHYLSTWLVVVLIYMHARPGVPY---YT- --GILAMLLFIMIAVTSLPRIRRVNFQLFYFVHYAATWLSVVMLQYHARPNMNM---IS- --GVFALGLFLLIAVTSIRYARRLSYRVFYYVHYISTWLIVVLLHYHARPGISY---HT- --GIVALILFCLIGISSIRKFRRWNFKLFYGIHYISTWLTVILLYLHARPGIPY---YT- --GVIALGLFLLIAITSVRYARRWSYRVFYYVHYVSTWLILVFLHYHARPGISY---YT- --GVIALGLFLLIAMTSIRYARRWSYRVFYYVHYISTWLIVVLLHYHARPGISY---YT- --GVIALGLFLLIAITSIRYARRWSYRVFYYVHYVSTWLIVLFLHYHARPGISY---YT- --GVIALGLFLLIAITSIRYARRWSYRVFYYVHYVSTWLILVLLHYHARPGISY---YT- ------------------------------------------------------------ --GAVALLAFVLIAATSLPAVRRRRFRTFYYVHYVGTWVSVLAVHVHSRPPVTT---YT- --GVLAMVLFLLIAITSLPRVRRTHFRVFYYVHYIATWLTVILLHFHARPPMSW---YT- --GWVALLGFVIIMITSLSSMRKRWYKVFYCMHYLWTWTIVVCLQFHIRPSPFTF--YT- --GVAAMALFILIAVTSVSGMRRYNFRVFYYVHYISTWLTVVLIHFHARPPIPY---YT- --------------------ARQIIYRLC------------------------------- --GWVALLGFLIIMVTSLSSMRKRWYKVFYCMHYVWTWTIVICLQFHIRPSPFTF--YT- --GWVALLGFLVIVVTSLSSFRRRWYKIFYIMHYSWTWIIVACLQIHVRP-QPFTF-YT- --GWIALAGFLIIIITSLSGMRKRWYRLFYSMHYIWTWIIVGCLQFHVRPQPYTI--YT- --GWAALLGFLLIAITSLSKVRDRSYKLFFFNHYFWSWAVVFLLPFHVRPVETT---YVN --GWVAVFGFLVMIITSVLKIRTVCFKLFYISHYFWSWVIVICLQFHVRP-VPFTK-YT- --GWAAFTGFIMMTITSLSSFRNRFYKVFFFEHYTWSWIIVITLQFHVRPTKATL--YT- --GILALLLFVIIGFTSIRKFRRFNFKLFYYIHYISTWLTILLLYLHSKPGIPY---YA- --GIIATALFLLIAATSIAPIRRKMYPIFYGIHYPATWACVFLIWGHARPPANG---YF- AMSLSILVAQ-VI--YRVRITRVCV-------------------AKVQRI----SP---- TFNIILLLGQ-II--YRLWNTRLST-------------------ISVIPV----SP---- TLNVAILMGQ-VI--YRLYVSNITI-------------------VTIVPI----ST---- ALNCFILICQ-IA--YRLCITNITT-------------------ASIINV----SP---- TLNVLILTGQ-IV--YRLHITNVTR-------------------VTIVPI----SS---- TLNVVILTGQ-II--YRLHISNIAR-------------------ATIVPI----SS---- TLNVLILTGQ-II--YRLHITNITR-------------------ATIVPI----SS---- TLNVLILTGQ-IV--YRLHISNVTR-------------------VTIVPI----SS---- ------------------------------------------------------------ VLNVALLLYQ-AW--YRISRMSTTT-------------------VTVVPI----ST---- LMNVSILVFQ-IG--YRLYHTKRTR-------------------VSIVKV----SP---- LANVSILVGQ-IA--YRVCLTRVSN----------------KGEVKVFDV----SP---- AMNCIILIVQ-IG--YRVFHTAKVR-------------------VTVVPV----SD---- LTDVTIHDTD----------------------------------MKVTNI----SS---- LVNVSILVGQ-IA--YRVYLTRVST----------------KGEVKVFDV----SP---- LANIAILVGQ-IA--YRWHLTRVSV----------------RGEVKVIDV----SP---- IVNVTILLGQ-IG--YRLYLTRVSF----------------KGEVKVIDV----SP---- ILNVSILSYQ-VF--YRLRSTSVST---------------STSSFKVRDI----SP---- AINVAILLYQ-IV--YRLRCTIKSK---------------TMESIKVNDV----SP---- ACNIAILCSQ-IV--YRLRASRTSQ---------------NSSEVQIIDV----SP---- LSCVSILLFQ-IV--YRLRHTKLTK-------------------VSIVCI----SP---- YCSLAILIGQ-IL--YRIWTTTHVK------------------PLSIFPV----SP---- -TLTLMEFPL------EQLALRP-------QYPGAHVRIRPAKGG---GLARAV----DY -AISVVEFPL------ADLSKKP-------ILPSGHVRMNNYHNF---WLKRWF----YH -SLSVLEFPL------ADLPKPP-------ILPGGHLRINIYHKN---FIKRWL----SH -SLTLFEFPL------DDIALKP-------ILPSGHVRIQIVENN---FLKRWF----HK -SLSLLEFPL------TDLPKKP-------ILPGGHLRINIYHRN---FLRRFF----SH -SLSLLEFPL------ADLPKRP-------ILPGGHLRINIYHRN---FFRRWL----SH -SLSLLEFSL------ADLPKTP-------ILPGGHLRINIYHRN---FLRRWI----SH -SLSLLEFPL------TDLPKRP-------ILPGGHLRINIYHRN---FLRRLL----SH ------------------------------------------------------------ -SLALLEFPL------ADLVEKP-------QLPSGHVRINLRAPS---ILGRVF----QH -SLALMEFPL------ADIPKTP-------TLPSAHLRINNYHSF--SFLKRWF----YQ -NIAMIEFPN------SLIAKTA-------TAPGAHIRLTNYSSS--FIVRAFK----QL -SMILVEFPL------SCLRKKP-------VMPSGSIRMAPFYKY--SPLKRIF----QQ -NLALVEFPN------HLIKCKS-------VSPGAHIRLA-------KYGSSWF-----V -NLAMIEFPN------LLIAKTA-------TAPGAHIRLTNYSSS--FIVRAFK----QL -NLSLVEFPN------SLISKQA-------TAPGAHIRLT-------NYSSSWI-----V -NLSMIEIPN------KLIAQVA-------HAPGAHIRLTNYSSN--FFVRTFK----QL -NLACVEFPN------SLIKKKA-------VNPGAHIRITNYHPN---FLVRVY----KQ -NLALVEFPN------DLIMNPA-------RKPAAHIRLTDCHPN--ILIRIWK----QI -NMSLIEIPR------KLIANAP-------TQPGAHIRCT-------DYHPNWL-----V -CISLLEFPA------EALSNKP-------ILPAAHVRINLKSKN---VWKRWI----NH -TLFLVTYPNGLPSFDRDVEDHDFDAKPV-FTPASHIRLS--SPL--WQPATWM------ LVNGLVVPLQHPFTIANL---P-----K---D---------DKIQLIIRSEK-----FP- LI-----PLQHPFTIASL---P-----N---E---------SMVRLIVRTGK-----FP- LV-----PFQHPFTIASI---P-----S---D---------SLVRLIIRNGH-----FP- LI-----PLQHPYTISSL---P-----T---D---------DTVKLIIRNGN-----FP- LI-----PFQHPFTIASI---P-----S---D---------NLVRLIIRNGH-----FP- LI-----PFQHPFTIASI---P-----S---D---------NLVRLIIRNGH-----FP- LI-----PFQHPFTIASI---P-----S---D---------TIVRLIIRNGH-----FP- LI-----PFQHPFTIASI---P-----S---D---------NLVRLIIRNGH-----FP- ------------------------------------------------------------ IM-----PMQHPFTVASL---P-----T---D---------TTVRLIVRKSR-----FP- LV-----PFQHPFTIASL---P-----S---D---------ETVKLIIRRGN-----FP- IP------NYHPYTLVSF---P-----T---D---------KYQRLIIRKSN-----FK- IA-----PLQHPYTIASL---P-----T---D---------TNVKLIIRPGR-----FK- RAYRQIIPNYHPYTLVSL---P-----L---D---------NYQKLIVRRGN-----FK- IP------NYHPYTLVSF---P-----T---D---------KYQRLIIRKSN-----FK- RVFKQIIPNYHPYTLVSL---P-----Q---D---------RYQRLIIRKSN-----FQ- IP------NYHPYTLVSF---P-----N---D---------KLQRLIIRKSN-----FK- LI-----PNYHPYTLVSL---P-----Q---D---------RSQKLIVRKSA-----FK- IP------NYHPYTLVSL---P-----T---D---------NYQRLIIRKSN-----FE- RAFKQIVPNYHPYTLVSL---P-----S---D---------ATQRLIVRKSN-----FK- II-----PFQHPFTVANL---P-----N---E---------DTVQLIIRNGNT----LP- -------KSSHPYTVASR---P-----E---D---------DHLQLVVRKSNF----FPD --MRD---------------------------------------GMRYHVSGAFEPVINF --LKT---------------------------------------NSKYYITGALEPKVDF --LRT---------------------------------------NEKYYVTGAFEPELSF --LKS---------------------------------------NSKYYITGAYEPVLNF --LRT---------------------------------------NEKYYITGAFEPELSF --LRT---------------------------------------NEKYYITGAFEPELSF --LRT---------------------------------------DENYYVTGAFEPELSF --LRT---------------------------------------NEKYYITGAFEPELSF ------------------------------------------------------------ --LVN---------------------------------------NGKYYVTGAFEPKVDF --LKR---------------------------------------NTDYYVTGAFEPKIDF --LYN---------------------------------------MRRYMIAGSYDPHLLF --PRN---------------------------------------NSEYLVTGAFEPKIDF --IQN---------------------------------------RHKYLICGSYDPNLLF --LYN---------------------------------------MRRYMITGSYDSHLLF -----------------------------------------LFDGHKYLITGSYDPHLLF --LYN---------------------------------------NRRYLIVGSYDPHLLF --WQA---------------------------------------NRRYLVFGSFDPKLQF --FTN---------------------------------------GKKYLIYGSFDPHLLF --FKE---------------------------------------KRRYIFTGAFEPHLLF --LIT---------------------------------------NGDYYITGVFEPMIDF TTLHA---------------------------------------NRNMSLTGPF------ LTKPRNLADSLVKYRSTFALGRGTQALLGSPLNYIVDSQ-RVLIVVGGTGISFGLPLLRV MSKSGSRDN---NRLL--PFQSATPMLLLSPLSFNINAK-RVFMVVGGSAISFGLPMLRI ISKPSFPIDAS-TRSSRNPFRNNSSALISSPLNFIIKAQ-RVFMCVGGSGISFGLPLLRI MKK--TKNSET-ESIIRDPFRINSSQLLHSPLYYAINAR-RVFIIVGGSAISFGLPLLRI ISKPTVPFNIT-TKSSKNPFRNNSSALINSPLNFLIKAQ-RVFMCVGGSGISFGLPLLRI ISKPSTPFDIT-TRSSKNPFRNNSSALINSPLNFIIKAQ-RVFMCVGGSGISFGLPLLRI IFKPSSPFDIS-TRSSKNPFRNNSSALISSPLNFIIKAQ-RVFMCVGGSGISFGLPLLRI ISKPSSPFDIT-TRSSKNPFRNNSSALINSPLNFIIKAQ-RVFMCVGGSGISFGLPLLRI ------------------------------------------------------------ LSHRKRRMPGSWAPEPASPFQCQSPSLQSSPLHYNIKAS-RVLMVVGGSAISFGLPFLRI IKKDSVKRPRD-SSTY--TFQNSSPTLLTSPLSYHIDAR-RVLMVVGGSAISFGLPMLRI IG--------------------SKSSQNFSLSKLSVNAK-RLLIVIGGSAISFALPILRV ITKNLTKVP------I--SFQNQTPALLASPLHYNIDAR-RALIVAGGSAISFGLPLLRI LNSK------------------NTAKGSFSISKLRVSAK-RILIIIGGSAISFALPILRV IG--------------------SKSSQMFSLSKLLVNAK-RLLIVIGGSAISFALPILRV INYKIASVATSNNYTNNHNNKNTSKNNKWMLSKLHVDAK-RILIVVGGSAISFALPILRA IQ--------------------SLPSPKFSLSKLKINAK-RLLIVIGGSAISFALPILRV VHSN------------------NTPGQVFSLSKVKVTAQ-KLLLVVGGSAISFAIPILRV IGSK-------------TSSFSSPASSKFSISKLSIDAK-RVLIVIGGSAISFALPILRV VSTK-----------------PKKGQDNFLLSRLQVNAK-RVLVIIGGSAISFALPLLRT ITKPCTLTE---ESLHNFHFQVKSLPLLNSPLRYQINAR-RVFMCVGGSAISFALPVLRI ----------------------CSVPSTFFI---PGAAK-RVLLVCGGTGISFAAPVLRH LNF-------------------------NGCLVKLKWAIRDFRDLRILS------HIRNN LNF-------------------------NGVTVKLIWVTRDHRDMKILN------VFKNN LNF-------------------------NGVNVRLLWVSRDYKDLEVLN------HFKNN LNF-------------------------NGVNVRLIWVSRDFHDLKLLN------YFKNN LNF-------------------------NGVNVRLLWVSRDYKDLEVLN------HFKNN LNF-------------------------NGVNVRLLWVSRDYKDLEVLN------HFKNN LNF-------------------------NGVNVRLLWVSRDYKDLEVLN------HFRNN LNF-------------------------NGVNVRLLWVSRDYKDLEVLN------HFRNN ------------------------------------------------------------ LNF-------------------------NGVNVRLIWVCRDYHDLRILS------QFRSN LNF-------------------------NGVNVRLIWVSRDYRDLRLLD------HFKNN MNY-------------------------HGIPTKIVWVIKDFRDVLVLR------YFDGF LNF-------------------------NGVTVRLKWVTRDYRDLKILN------HFRNN MNY-------------------------HGVPIKIVWVIKDFRDITILK------HFDGF MNY-------------------------HGIPTKIVWVIKDFRDVLVLR------YFDGF MNY-------------------------HGVPTKVVWVIKDFRDILVLN------YFDGF MNY-------------------------HGIPTKIIWVIKDFRDVLILQ------YFDGF SNY-------------------------HGIPVKVIWVIRDYRDISVLR------EFDGY MNY-------------------------HGIPVKIVWVLKDYRDISILK------YFDGF MNY-------------------------HGVPTKVVWVIRDYRDISILR------HFDGF LNF-------------------------NGVHVRLIWVTRDYRDLKLLN------HFRNN CAD-------------------------RGIPCKLVWAIREVRDVAILP--LLGIRCDTS FE-G---------------MEVY--ISGQGAEDEIEIEYTDNDFSDNEHTPLLSHHHMQG YN-G---------------LEIF--VTG-TLGAEQDLQIDYVDYGPDPLG---LPHPELQ FE-G---------------MEIY--ISG-TEGNEQDIEIDYIDYQDPHTN---VAHEGSN FE-G---------------MEIY--ITG-FKGNEQDIQIDYIDYEHQR------------ FE-G---------------MEIY--ISG-TEGNEQDIEIDYIDYHDCAAD---INDEVRS FE-G---------------MEIY--ISG-TEGSEQDIEIDYIDYHDPSSD---LDNEGSN FE-G---------------MEIY--ISG-TEGNEQDIEIDYIDYHDPSID---IDNEGIS FE-G---------------MEIY--ISG-TEGNEQDIEIDYIDYHDSSAD---IDDEGSS ------------------------------------------------------------ FN-G---------------LEIY--VTG-TNCEEQDLNIDYVDYDERSSEGERDPERCAL FH-G---------------MEIY--ITGMNDGEEQDLQIDYVDYEDDTMN---DSEFEED IH-GDD-------------FEIF--ITGDSTIKEQA-----KTLRNAISCASNFSKKSRI FD-G---------------LEIY--ITG-SIGEEQDLQIDYVDFDEDP-----------D IH-EDD-------------FEIF--VTGSSEVGQDSAMRRYDSMNDMSSNGTSNTTHLYD IH-GDD-------------FEIF--ITGDSTIQEQT-----KTLRNVISCASNFSKKSRL IH-GED-------------FEIF--VTGSNTLDEKSITLKNCKSNLSKRSIGALSAHYDL IH-GDD-------------FEIF--ITGETLIKEQS-----KTLRNEISYASNMSKHSHL IH-GDD-------------FEIF--VTGGVATDSEM-----SSMKMPSYGTFNTTDLEQN IH-GDD-------------FEIF--VTGTSEIKEEK------LLRNSISYGSILSRKSII IH-GDD-------------FEIF--VTRSENNSNRSSVHHSFTYDEENEEMPLLDQDEDD FE-G---------------LEVF--VSGENSIEYIEHETLTSLDSASPNS---------- VN-VE--------------IEVY--VSRPITSLSPTKAGIMNDYRSSLGNKDEAAAADDI GSLLDSMDHVGSGNARAMDPGAKRDT------------------KATNNANGVNSANGAN EPVPQA-LPSSSDYNPETTLTSSSYPKYGSIS--------------TDK----SAFSSDL APSRAQGYGLRDDSMLSDA-----EPNENSAL--------------LSKKSTLRTHQSTK ---------NNELCAVNNTENSYLLTEHERTS--------------HENRHFHKCNTTNN ISSSGRVSELGDNSMLSDGNPQPTEPNENTAL--------------LSKKSTLRNHHPPK LSSREQVSALGDNCMLSDATAPRTEPNENTAL--------------LSKKSTLRTHQSTN LS--EHVSELGDNSMLSEDTAQR--PDENTAL--------------LSKKSTLRTHQSTK ISSSERLAQLGDNSMLSDGNSQPTEPNENTAL--------------LSKKSTLRTHQSHK ------------------------------------------------------------ LSPKASEYNCLTPTTGGSTLSGRDAHNYSTFQN-----------RCHSCKHLDRGCRDLE SQSDESQVPTDSA-----RLMARSTSGYGTIK--------------TNNLYAVKTTQSLD SSHFDIEHDETSPLLSDNNESQIPLNLENQIENVDI--------SMNSDDEEEQDSDSDC VMADQGSTPVRHD-----TVSSFPGSNYGTFK--------------STDFSSGRTFQS-- LESENLPLLGEESKYDDVTGGENEDVEISIDNEE----------DEYDDECAVDVTMREH SSHFDIEHDETSPLLGDNNEPQIPLNLENQIENVDI--------SMNSDDEEEEDSDSDC ENERIPLLGSNEQITSLNQENQVEDVDVG---------------INSDEEADAIDDGDSV SSHFDLERDETTPLLGNSNEPQITLNL-----------------ENQIENVDISMNSDDE ESSRIFYSDDEEVGVNQEI-------------------------ENVDVDLSEEEDDEEC STSTRHYSEYDLERNEGSPLLDKDELENTAQFNSLHFENQIENVEVSMDNEEEETDDEDC EHESGIEREDVNIEVGDMEE------------------------TDDDEECTGLEVTEHE --------------------------------------------YLDEPPLNSKSKLLSG DINIEACGHGCCTPCQGNPERVPLLEAQKREA------------KHQEQQSQAQSHAQQQ GGYCLRNVARENTAD------------------EIDFTDVFKNDTEHKRVP--------- ----DHS--QKHNED------------------EFDFTNVYSATNTLKRKKSEPK----- ----TNDIPDSNADD------------------EIDFT--YAFGRSKSRKNITHG----- ----LTNLAGIDNSD------------------EIDFTGMFATHKPKSKSDINLS----- ----TSDIPDINADD------------------EIDFT--YAFSRSKSRKNTAQG----- ----TSGIPDINADD------------------EIDFT--YAFSRSKSRKNTTHG----- ----TNDIPDINADD------------------EIDFT--YAFSRSKSRKNTAHG----- ----TNDIPDINADD------------------EIDFT--YAFSRSKSTKNTAQG----- ------------------------------------------------------------ ----DHAIADIN--D------------------EIDFTDFFSTRHSTSKYHPKEN----- ----NQG--KINQDD------------------EVDFTQLFSARSVKSKNNLADK----- ----THNGINHSRYE--------------------DFNDVDDILVDSSDIEDGGS----V -----QG--RSNQED------------------EIDFTQMYSARGLKSKKSFLSQ----- FLDTIPDGHDDDSNN--------------------EEIEYFMDGEYENQDQSLLL----- ----THNGINQPRYE--------------------DFNEVDDVLLDTSDNEDGGS----I ----AFTDADCTHHTTHMGIQTSTPRNRCPDN-EFEVTNDTINQLPNAPQSPQQDSHLHL ----DDSGSDCTRSATPGPACEDLVQID-----DVTADDSFSDDMGGEYEESVDE--FEV ----QRDCTASHIELPQDMEDVSDISSLE---DEMDFSPATEVTSGISRKTSR------- ----AIDEYSHRNSQLFGLEEDINEEVGT----NVEPEDIRVQEYSPDELTPREL----- ----DDDGGSASSIH--------------------EDQGNTSLGRRTSYASTSEH----- FNSPATYGSTVDQSD------------------EIDFTQTFTVKKLKSKSKLSAE----- ----ALGEIPVSSNG------------------TIDYNAIQPVKAVPLLRRPRKM----- -----------------VGVFREPS--------------------------IIEEQEDRD -LFG----PPSPFHK--DEAFRKPK-VIIPPN---------DENYKS-DVESLEDDD--- -TLT----THSSLIG--SNVFRQPK-TIEPPP---------QEQ----QGDSPSATPP-- -NN-----ARQPLININTNFFRDPV-TLGFPQ---------NDSENFHPNEQLDENQDVD -TLT----THSSFNG--SSVFRQPK-IIEPPA---------Q--------DPCLEAAP-- -TLT----THSSFNG--SNVFRQPK-TIEPPA---------Q--------DPCLATPP-- -TLT----THSSFNG--SNVFRQPK-TIEPPA---------Q--------DPCLATPP-- -TLT----THSSFNG--SSVFRQPK-VIEPPA---------Q--------DPSLEAPL-- ------------------------------------------------------------ -S------KLPVITK--DSVFRKPN-YVVPPV---------FDRYDLKTGFTTYTTR--- -DYPCETVSSSPLSQ--KGIFRKPN-IVVPPN---------DSSYKS-DIESLGDDDG-- REFEITGDSLSPQNTTSRNVSRKSSVNEPFVP---------YFEQSSSDQTKSWVQQFKS -K------SMSSLDE--HGIFRKPS-IVVPPP---------EQAESTHSLPTSYGSEP-- ---PSSGSKPNIIRKNSMQRSRKPSRSRKTSVSTMNEIFFPSLNSDATDTAKNYLQQFKD NEFEITADNLSPQNSTLRNISRKSSVNEPFIP---------YFEQSSSEQTKSWVQQFKL HTRASSPLQASSPAVSSAHVSRRPSMNEPFIP---------IYSRSSPAQSISWISQFTS TNDNLNEQSSRSRSVSRKSSVNEPF-----IP---------YYLSSSSQQTKSWVQQYKR -----------------SQSINEQF-------------------VPLLDKSIETHRRCMK --------QIPSPAHSRKSSINEPF------I---------PTYNPNSTEAEVAMKSFRE -----------------FTPTLNHS---------------------ASFSTRQAHSTYSE ------LRTATNSSTDNISAFRKPS---IIEPPNAFGTDNISVNYNSTLDTISPPYTESK -----------------TSTLLRKS--------------------WIPTEYDSPLAQFTM KKIAIPSGVKVFH-GRPRLDQHDYNW------CMESE----------------------- MKLTIPAGVKLVF-GRPQLSNLDYQW------CLQKE--------CSLPSEVDDCCVMNS KKIRIPAGVKVFF-GRPTLGDKDYEW------CLQTE--------CDAETDSIQCCRWAN MNLKIPSGVKVFF-GRPILDDKDYEW------CLQRE--------CSLDSEGNVCFDR-- KKIRIPAGVKVFF-GRPTLGDKDYEW------CLQTE--------CDAETDSIQCCRWAN KKIRIPAGVKVYF-GRPTLGDRDYEW------CLQTE--------CDAETDSIQCCRWAN KKIRIPAGVKVFF-GRPTLGDKDYEW------CLQTE--------CDAETDSIQCCRWAN RKIRIPAGVKVFF-GRPTLGDKDYEW------CLQTE--------CDAETDSIQCCRWAN ------------------------------------------------------------ EKLSIPTGVKLFF-GRPVLSPRDYHW------CLQKE--------CIGPSETNECCRADI MKLKIPTGVKLFF-TRPHLGSQDYQW------CLQKE--------CIGPSETNDCCQPNT LTRRLNLENKIYK-GRPKLNHRYYNW------CINEGFTQCSGPTEDENHNLICCRDLP- KSLKIPAGVQVFF-ERPNLTNHDYQW------CLERE--------CIGPSDTNDCFRLNG TAKRLKIEHRIYK-GRPRINYKYYNW------CINEGFTQCSGPVDDGSHNFVCCRDLIK LTRRLNLENKIYK-GRPKLNHRYYNW------CINEGFTQCSGPTEDENHNLICCRDLP- LTRKLNIQHKIYK-GRPKLNYRYYNW------CINEGFTQCSGPTLDEHNNLVCCQDLP- LIRKLNLENKIYK-GRPKLSYRYYNW------CINEGFTQCSGPVEDENHNLICCRDLP- TLQQLNLQHHIYK-GRPKLNYRYYNW------CVNDIFTQCSGPVMDESSNVVCCRDLPG TLKRLNIENKVYR-GRPKLNYKYYNW------CINEGFTQCSGPVEDSDHNLVCCRDLP- TVKRLNIENKIYE-GRPTINHKYYNW------CINEGFTQCSGPVKDGSNVVCCRDLP-- PKIKIPAGIKVSF-GRPLLDNSHYTW------CLEKE--------CIGPSETNQCYNSDN ISSKLALNLDLAKWGVPPCGSRNSTHTTGGTCCMQVP----------------------- -CGVNDVSVDKRRVWVV--AAGPPGLIDATSRWSTDS----------G----LRFHGESF DVNITHVD-DLANVWVV--AAGPKGLVESTKRWATDG----------G----LHFHEESF Q-GRDHAE-YLSQVWVL--AAGPRGLIESTRRWAVDG----------G----LHFHGESF --SINDAE-ELSNVWVL--AAGPDGLVEGTRRWATDV----------G----LRFHGENY Q-GRDHAE-YLSQVWVL--AAGPRGLIESTKRWATDG----------G----LHFHGESF Q-GRDHAE-YLSQVWVL--AAGPRGLIESTRRWATDG----------G----LHFHGESF Q-GRDHAE-YLSQVWVL--AAGPRGLIESTRRWATDG----------G----LHFHGESF Q-GRDHAE-YLSQVWVL--AAGPRGLIESTRRWATDG----------G----LHFHGESF ------------------------------------------------------------ A-NSTHVD-DLARVWVL--AAGPQALVEATRIWASDG----------G----LHFHEESF --NNTHVD-DLSQVWVI--AAGPPGLVGSTRRWATDG----------G----LHFHAESF RNKVVQEDLNAEKIWVI--SAGPKPLVENVKLWATEY----------G----LKFHEEAF --PAAHVD-DLSRVWVI--ATGPPQLVENTKRWATDG----------G----LHFHEESF DKG---NKVDSNKVWVI--TAGPASLVKNVKLWANEN----------G----LNFHEESF RNKVVQEDLNAEKIWVI--SAGPKPLVENVKLWAAEY----------G----LKFHEEAF RNKVVEEDLNAEKIWVI--GAGPKQLVENVKLWSSEN----------G----LKFHEEAF RNKVVQEDVKAEKIWVI--SAGPTPLVENVKLWASEY----------G----LKFHEEAF RTHKSAPMSSLENVWVA--SAGPKSLVKNVKLWASEN----------G----LRYHEEAF KNRVRQEDINAEKIWVL--SAGPKPLVDNVKLWANEY----------G----LKFHEEAF --RAHVPITDRKDVWVI--SAGPKALVNNVKVWANEN----------G----LNFHEEAF --KDDTHVDDLASVWVV--AAGPESLVENTKRWAKDG----------G----LHFYEESF ------GLVDKTGCWVL--ASGSVQLVRETSKWAADN----------S----FLCVKDEY AV-MFWIKSKATDNRFTYRSLVRNSIVKNNPVFSATDKYKDKNNSRLLSRLPRFHQYFNT SV-LLQSLSCSKMVRYSIRGPAKLFINGYNSSKVESKI-DDRKKSKFLTRLPRYKHYFDK AL------MNSKIIPFELKPNQLNMLAGFITENVETKRGKDKSKSRLLTRLPKFSHYFDR AI-AHMKLISGGLSPLRQRFLRLGMPLSKLAGGIE-RKYDDRSKSKVLTKLPKFSHYFDR AL-NLFFRMGSG--PLELRPTQLTTFMNFISGNLDVKRREDRSKSRLLTRLPKFSHYFDR AL-MTLFRMNSKIIPFELKPNQLNMLAGFITENVETKRGKDKSKSRLLTRLPKFSHYFDR AL-SFLFKMNTRLVPLVLRPTQSATLIGYVSGNVDTKRKEDKSKSRLLTRLPKFSHYFDR AL-KFFFRTSSRFIPLELRPVQLTMLMGSISGNVDVKRREDRSKSRLLTRLPKFSHYFNR ------------------------------------------------------------ KV-MLPHLLVPGRGSFRLHLASRGGASGARAYGSPGDARQTRARSRLFQRLPSFAAYIDR SV-MFMFRLPARLTTVSLRSTSLLRGYSLECGDEKKTVQNERSKSRTLTKLKRFSHYFDK YS---------------------------------------------------------- TL-MMIQALNSLASGTSLRALNIVLPHAKVQPDPEEKGNATAAKSKFLSKLPRFRRYFDS YV-PLSILMSKQMHVVSLKKVEKVISGGGLSGSVSNQVSNGNEKHPILKRMPKFMLPYTK YS---------------------------------------------------------- YS-LHYSLFHSSAILFGKEPISSASPSAFLKRDIPAERPSGPKTHPILKRIPKFLRNYAS YS-TMIRLIKPCLYPFGVRAFATTTP--SKPQVTRSSISKEQDNHPILKRVPKFLRSYAS YV-MLLFRRPRGLILNRSSPLSLLFKGGTEIKPVAISPKQSDRKHPILKRVPRFLRPYTT YA-------------------------------------------PILKRIPKFLHRYTT YV-MLMLTVFSPRI----PLLGRASLHSLLSQKLPNTPVTPPSGSKILDKIPRFLHPWTK AV-LRNLQTSFPYIFFKSRIVPRVILSSNQESNTKYKHKNDISKSRLLQKLPKFANYFDE SM-TFRTLGLLTPLALTPTLTPLSNPASFLFRKREHPDDNDP----ILKHIPRFIRPLAR VSETGTITTLTSFLVLHELTAIVPLFGMWWVIYNLDIHNDLELPGYLLERCSKAIDKIVG LSEAGAVSTMTSFLILHEITAIVPLFALWGLLYNLDLSDQYEMPVYLLNKCGESIGKLIG ISEAGTVPTITSFFILHELTAILPLFLLWWLFYNLDISDDLKLPNFLMESCHAAMERLVG ISEAGTLSTFASFLLIHELTAILPLLLLWWVFYSLDIHDGHDLPHVLVDQCGKAINKLVG LSEAGTVPTLTSFFILHEVTAILPLFLLWWLLYNLDLSDDFKLPNFLMDSCHTAMEKFVG ISEAGTVPTITSFFILHELTAILPLFLLWWLFYNLDISDDLKLPNFLMESCHAAMERLVG LSEAGTVPTLTSFFILHEVTAILPLFLLWWLIYNLDISDDFKLPSFLMDSCHTAMEKFVG LSEAGTVPTLTSFFILHELTAILPLFLLWWLLYNLDLSDDFKLPSFLMESCHAAMEKFVG ------------------------------------------------------------ LLANGPVPTLAAFLLLHEATAIAPLALLWWGLYSCDVVLPQGLLDYLADAAHPAVERFVG LSQAGAISTVTSFLVLHELTAIVPLFGMWWVLYNLDLTDQYDLPVYLLNKCGDVIERLVG ------------------------------------------------------------ LSETSAVSTVSSFLILHEVTAIIPLFGFWWMLYSLDLDQQYELPVYLLDQCGDSIDKLVG NFIHAPVSHVTAFLILHELSAIVPLVGIWYVFHKYQWSIPLDLPSWAIDKGTHIIDKSMA ------------------------------------------------------------ QFIHAPYSHLVAFLVLHELTAIIPLFGIWYYLHNHPGFIPMDLPQWALTKGASVMDKVLE KFINAPISHLISFIILHEITAIIPLVSLWYFFHNHPNYVPMEIPNWALEQGAKVIDYAIT QFIGAPVSHVTAFLILHEFTAIVPLVGLWYVFHQHDLFASMDLPAWAIEKGTKVIDSAMA RFMNAPVSHVVSFLILHELTAIVPLLSLWYLFHQFDMLPSFDLPTWAIDKGTKIIDDAMN QFVNAPISHVTSFLILHEITAIVPLVGIWYLFHHYNWMIPMDLPHWAIQKGTAVIDKSMA ISETGTITTLTSFLILHEATAILPLFIIWWFMYGLDMPEHTELPGFIMENCNAFIEKFVG RFKNAPVSYVTSFLIVHEITAIIPLFGLWWYFNRYDF-VPPGLPDWLIVKGMSVIDKLLE DKYGQDLDRHRLILSGAISYTIVKLLYPLRIILSIWWAPHCGRFIVTPIRKLLKYLKPSD D-YDNGWDRDRLVVSGALAYAIVKVLYPARILFSLWAAPYVGTFVIMPFTKLRALIRRMN KRYQECLNKNKLILSGTIAYVTVKLLYPVRICVSIWGAPYFGKWLLLPFQKLKHLIKKSE DKYNDTLDKGRLVIAGTLAYAIVKLLYPVRILFSIWGAPYVGKWLLLPFYKLKSFRK-SS KRYQECLNKNKLILSGTVAYVTVKLLYPVRIFISIWGAPYFGKWLLLPFQKLKHLIKKSD KRYQECLNKNKLILSGTIAYVTVKLLYPVRICVSIWGAPYFGKWLLLPFQKLKHLIKKSE KRYQECLNKNKLILSGTIAYVTVKLLYPVRICISIWGAPYFGKWLLLPFQKLKHLIKK-- KRYQECLNKNKLILSGTIAYVTVKLLYPVRIFISIWGAPYFGKWLLLPFQKLKHLIKKSE ------------------------------------------------------------ DRAPAC-DRGKLLVSGALAYGLVKLLYPVRILASLWAAPYLARGLLLPFRRLKQWWKGMN DSYD-GFERNRLVLSGAIAYAAVKLLYPLRVIVSLWGAPYFGNWVMLPFKKLKLKLKNSK ----------------------------------------------------------AT DHYQ-GLDRNRLILSGAISYAAVKLLYPIRVLVSLWAAPYFLRWFLSPFKRLGRFFLPMN QRNFSFQEKANFIMEGAYAYVIVKGLFPVRIIFSVLSMPWFAKYFVIPFTRMFSFRKKMS ----------------------------------------------------------AT RWHIDSSQKISVIMEGAYAYTIVKFLLPVRAIVSLAGMPFFAKWFVVPIANLPKNLREVS KWEINSKDKMQLIIEGAYAFSIVKFLIPARVMISLYLMPWFAKWFVVPISNIFSNFRQAS NGNYSLNDKVKFIMEGAYAYVIVKALFPIRLVFSLVGMPWFAKWFVLPFTKMFSRKAK-- KADYSINEKFQFIMEGAYAFVVVKFLLPIRLVVSLGLMPSFARWFVIPFTKIF-----MS RGDYSLQEKARFIMEGAYSYVLVKAMFPVRLFFSLTMMPFFAKYVVIPFRRLFKKKPTMS KDKFVNLDRNKLIMTGTLSYMIVKLLYPVRILFSLWAAPYFGKWLLMPVKTLRKLIFKSD TSFLNMENSARVVMQGAAAYALVKATLPVRIPISLLLTPPFARWIFIPVGRMFKNVFSMS KIEEEVLELIRRSNFKQCYDYVGKLRKQYPNSAFLLALELYVKYRHTPQKFD-RTLLDTI SEDHQLFQLLDRELFKKASQFVASLQKRYPSATYYKVLEQYVKYRQSPAKYSFENGLKLI KIQEEILDLISRSNFKQCYARLGQLQKQFPNAVYFKILETYAKFKQSPGKFDYKKLLDEP KIEEEIFQCIERSNFKQCNEKIALLKRQFPKSAYISTLEIYAKFKQSPTKFDYEKDLGNL KIQEEILGLVSRSNFKQCYAKLGQLQKQFPNALYFKILETYVKFKQSPGKFDYNKLLEEP KIQEEILGLISKSSFKQCYAKLEQLQKQFPNAVYFKILETYVRFKQSPAKFDYKKLLDEP ----------------------------------------MLSLSNRPSKFDYIKLLDEP KIQEEILGLISKSNFKQCYARLGQLQKQFPNALYFKVLETYVKFKQSPGKFDYDKLLDEP ------------------------------------------------------------ KHEEEILTLVQKDSYKQAINAVSKVVRQFPSSTYFRLLEQYVRFKQSPSKYQYELMLGPL QERDNVLELIERGSFKQATQSVAKLARQFPSATYFKVLEQYVRFRQNPGKYSYEKGLAPI ERDQEIIDFIDQGNYTYAQSLITKKLAKSPQKLFYHVLQNEIHLKSGQRELAIKKNLELL TGGDEIIELLKRGNLRAAQQLARKLVTQFSSASYPKVLEQYVKFRQNKQKYSYESGLEPL DPDQDILDAIEQGSFNYAQSLLSIRLKKYPNNTYYGALNCYLLLSSGKINESIDQSLKLM EGDQEIIDFIDQGNYTYAQSLITKKLAKFPQKLLYHVLQNEIHLKIGRRELAINKNLELL DSDQEIIGLIDQHQYGYAQSLLLQKIKKFPQRTLYPLLQNRILYRTGHKQQAIEKNVQLL NSDNEIIELIDQGNYNYAQTLLAKKIAKFPQKSLYYALQNKIFLKMGQKDLAIKKNIDLM MASDPILEAIEEGRFAAARRDLESKLKRFPDKSYYLALNCFYLAETGNASAEAQRTLK-- DSDAEILDLIDQGSYAYAQTLLAKKIKKFPQRSYYYALNNQLLHKLGKTKQALEANLKLM ETDASILSAIDQGQFSLAQSLLSRKLKKFPNKSYYWAVNCYLLVSSGKHEEALSQSNALK KIEAEIFELIKKSNFRLCNERIGQLRRQYPKSSYFEVLETYIKYKQSPTKFDYEKLLGEK TRDKSIWEAIEAGTFKQARALIAKAQKKAPKNTYYGALNALVSVLSGNKEEALKEAEDLL --QTSETHALSFLYKFYVELLCYDKALGVYEIAATKYPSYETSYMWFSKAVEVNDYKAMA KSPPSDAKSLSMCHRFLLELGDTTSALEPYERAMMKYGNSETCYDWFLESLRDLNWRHLS TTITGDSRSLEFLHNFFVELGRYDEALHVYERGNFKFPSYELSYHWFTKALEDSNYNQMS SLITSDLRALDLLHKLFIELERYEEALHVYEAANFKYTSYELVSQWFEKALEDFHFNHMA TTITGDTRSLEFLHNFFVELGKYDEALHVYERGNFKFPSYELSYHWFMKALEDSNYNQMS TKITGDTRSLEFLHNFFVELGRYDEALHVYEKGNFKFPSYELSYHWFTKALEDSNYNQMS TKITGDTRSLEFLHNFFVELGKYDEALHVYERGNFKFPSYELSYHWFSKALEDSNYNQMS TKITGDTRTLEFLHNFFVELGKYDEALHVYERGNFKFPGYELSYHWFMRALEDSNYNQMS ------------------------------------------------------------ TTLPHDAKSLDLLRTFLLELYSPIPPLKPYETAMKKYPTFDLCYRWFQQAIQDLDFNSLN QSPPNDSKSLELLHTFLVELRMYGLALAVYEKAMKKYPTFENAYHWFVKALDDMNFRHMG NRYPNDPLTIEKLSDFFSKMEMEKESSLVYENAIKKYPVSTLCLSWFDNSIEKYDFKVFN TSPPSDARSLSLLHTFLLELGRLDEVLNVYGAAMQKYPNLETGCNWFVKAIEDMNLKQMV AKVPNDPKTLGLLYTIFNKAGRSKEASVVYENTVKKYPTNSIILSWFETSLKNFDLKALQ NKYPNDPLTIDRLSDFFSRMEMEKESSLVYENAIKKYPISTLCLSWFEKSIEKCDFKLFN KSIPNDVDSIIMLSEFFQDVGMEKEADACWENVIQRYPIKELVLIWFENSVLQLNAAKFN NKVPSDPLTIEIMSEFFEEIGREKESSLVYENAIKKYPVSNLCMNWFENSIAKKDFKLFN QKVPSDAKALDLLSRAFKKLGLPTEANEIYENAVKKYPTTDLILTWFFKTIHSFDTRSAQ EKIPNEPQTVALLSDYFSELGYEKEANLVYENVIKRYPTNSLIKEWFERSIDKFNLRLFN EKVPSDPHALEMLYKVFELLGRPKDANMIYENAVKKYPSADLIECWFQLAVSKFDIKTMQ KLITSDLKALDLLHTFFIELERYPESLNVYERAIFKYPTFELASAWFDKSLNDSNFMHMA ATDPSDQRTVMMLSNVFTRLDRPDRLLPLFEGYAKKNPAASTLETWLWAMVDSGNTYGQQ RASLQMAKYLECRDYLIWHAISVVALFRWKRSSVSKVLPQLCYKNMLSLKPFKSVQELII KSSFQMPRVSKSRLFQFWNSIATVVWFQLDKDNINDLLPKLTYKLTSDLKPFENEQELIV KASLQLAKYLPKRAYYFWNAISTLAVMRFQKSTVSVVLAKLARQSLLDLKPFENVQEIIV RSSLQMVKFLPSRNYYFWNALCVIALFKFQNDKVTKILPQLAYKNLCNVKPFQSNQELIV KASLQLAKYLPKRAYYFWNAISILAVSRFQENTLSILLSRLARQSLLDLKPFQNVQEIIV KASLQLAKYLPKRAYYFWNAVSTLALMRFQKNTLSAVLAKLASQSLLDLKPFQNVQEIIV KASLQLAKYLPKRVYYFWNAISTLAVVRFQESTLPIILARLARQSLLDLKPFENVQEIIA KASLQLAKYLPKRAYYFWNAISILAVTRFQKSTLSVVLSKLARQSLLDLKPFQNVQEIIV ------------------------------------------------------------ RATFQLSRFKDVRAAKFWNAVVLLSWARVRPATMAQLLPQLAYKILVQLKPYPKEEELVV KAALQLPRFSDPRSLTLWHAVATVALFKYQRSGLSKLLPHLAYKSVDGLKPLVTDQERIV RIFMYLNKNGKSRLHTLWYAFSFHLLLQEGETDKASLYNSLGKKLMEGLQPFENTQEIYV QASFQMRRLSDPRMLQFWNAMSTVALMKLQGESLNQLNAMLSFKTVASLAPFQSDQETII KSTMNLQKVKSNRSYSMWSSLSCLILSNNSNDPKELLFNKLGLKLLENLQPLLTTQEVFV RIFMYLNKTGKSRLHTLWYAFSFHLLLQEGENDKANLYTLLGKKLMEGLQPFENTQEIYV KIFLYLNKSKKERKYTFWYAFSFYLMITENEKNQQNLYKSFGKKLIEGL-SFANCQEIYV RIFMYLNKNKKSRLYTLWYAFSFHLLLKEGDNEKEKLYTSLGKKLLEGLQPFENVQEVYT KASMLLKKHKSNRAYAVRAAFVNFLWSLQSPSEKETLHLALAESILNDSSPLESNQEIFA KIFVNLSKSKSSRLYKFWNSFSYFLLLSNKEADLSDLFKTLGLRLIEDLKPFENTQELFV KAAMALQKHKGDRKLAMRAAFCCLNLASSKVCKITTLYSNLGEKLLESF-DFVSTQEVYV KASLQMVKYLQNRDFNFWYGISIAALFKFQPHRITRILPTLAYKTISNLKPFNSHEELIV RAAMALSKTEKSRRSVFWAVYSGLVALEEGSIPDKAIISMLSTRMCEQQRPFVSAEEVYV FCEVCEFDNKSKEIVDQILPADLYLKNFFVRNIDSLE-PQERYNSCIKILANYDDFSVIE FCKVCEFEDKSQEIVDEILKLDLYLKNFLMGHLVKLDDYKLIWKHGISLLNNLDDYGILQ YCLVLDSREISEEIVEITLIVNLYLKNFILKHVKLLDSPQKLFEVCSKLIKGLDDYELII FGLLIEDEEKINELINLIVPVDLYLKNFILNFLND-RNPELLFECCKIILKHIDDFEAIK YCLVLDSREISEEIVAITFAVNLYLKNFILKHTKLLNSPQKLFEVCSKLIKGLDDYELIT YCLVLDSREISEEIVAVTFVVNLYLKNFILKHVKLLDSPQKLFEVCSKLIKGLDDYELII YCLVLDSKDISEEIVEIAFVVNLYLKNFILKHAKLLNSPQKLFEVCSKLIKGLDDYELII YCLVLDSREISEEIVAITFVVNLYLKNFILKHAKLLDSPQKLFEVCSKLIKGLDDYELII ------------------------------------------------------------ FCQVCEDEDKAAEIVDEILTLDLYLKDLLLDNLLKLERHADLYEVCGKLLVHLDDFVLCK FCHVCEGSDRSREIVDELLPVDLYLKNFLVDHLRRLGDDANMFKSCEKLLVYFDDFELLK YTLFLSSKEIEQVLSGVTLPLDLELKLLYMKAMKENASFEALHAYTEKLLEKFDDFDTWK FCHVCEFEDKSREIVDQVLPVDLYLKNFLIKHLDILGDDENMFKCCKQLLKYLDDFEIIS YVKLLYNLEEFSQIESYLHQLDLELKLIYLDILNILEKWDSLYSYANQLIENFNDFDTWK CTLFLNFKEIEQVLHGVTMPLDLELKLLYMKVMKENRNFEALHAYTEKLLEKFDDFDTWK YTRFL-LLDKDYSSIESLLALDLELQILYLESMKQNKNWEKLHAYTENLLKKFDDYNTWL YTLFLNSKEVEHVLQGIEMPLDLELKLLYMRSMEENESFTQLHKYAEELLDNFDDFDTWK LATILSKRGKYDQVVELLAPRELELTLLYLDCLFRLENWEALYNLCHQLLEEFNDYDTWK YFNFLKLNKDYETIISSIEKLDLDLKIMYLEVLQKSENFQKLYDYSKKLIEDFNDFNTWL YCKLLKNNEKYQEIASLLSSLDLDLQLLYLDALDKSEKWEELYSLAKKLLVQFNDFDTWK FCTICEDRAKASEIVQEIFPVNLTLKNFIVHNASIIEDNQLLFNSCQIILKSIDDYDVIK YAKLLWAQGKKTEAIETLQKNNLELTIMLREYLKESEQWSALFDHSKKVVQDLDDWAHWK CLLRAGMDLNIDKNTVLDKLIGDSRNFRVANLKADVIFGRVQEHALKFYIDKFYNKPCCH KIIDASYKLGKSFDELLEVLIKNTRNYILARVAAAKLYDDRLDHYLFQFIEKYHDKPSCP NLIEAAYKLSKPQEELQHWLLGDSRNTRLARLKLDMVYKSVSESSLSYYLSKYHNKPCCS SLLHAAKETAKTKEEALSLIVGDSRNSRLARIECDLMFREVSKKSLLFYLEKNHNKPCCA NLIDAAYKLSKSKDEVKQWILGDSRNTRLARLKLDIMYDSVSESSLSYYLSKYHNKPCCS NLIDAAYRLSKTQEELQRWILGDSRNTRLARLKIDIVYNAVSESSLSYYLSKYHNKPCCS NLIDASYKLSTPQEEVKHWILGDSRNTRLARLKIDIVYSSVSESSLSYYLSKYHNKPCCS NLIDAAQRLSKPQEEVQNWILGDSRNTRLARLQLDIVYDSVSESSLSYYLSKYHNKPCCS ------------------------------------------------------------ TLAQSAHKLGLPRADVESQL-PATRNGLLTHLELGVLYGRVTTDDLQPYLARFHDKTCCP ELIRSGNSVGKSRDELAQQLLRSSRNYRLARLELDLVIGGITDGALRQYLERFHNKPCCS LWILSGKEIGKSFEELDQKLTSPTRNISLLKIELDILYSRNIETSVENYYQKFNTKLCCY KLIKSAQRTGVSKEEVLQLLFRTSRNHVLARLELDAIYGAISEEALSFYLDRFHDKPCCF YLISSSFQRNSPVSDLKNIIHPKSRNSKLALVEMAKVYNVPMDEFVFEYYNEFNHKSCCF LWILSGKEIGRSFEELDQKITLPTRNISLLKIELDILFSKNIETSVENYYKKFNTKLCCY LWIQAGKELEHKYENVELKLKNYSRNKLLTNIELRKLYGCDYTDAIEAYYNVFKSKLCCY LWIKSGQRIGKTFEELNNKVTDSTRNSLLLKIELDRLYGKNIDNSIQKYYNKFNNKLCCH YLIMAANNLGMSETEISTLISSNSRNAYMAKIELAKVYESDIETSVLAYYDSFATKPCCV LLLKASKKLNYSFSETFTLIQPSTRNSLLAAVELAILYEQASFASIESYYIKFNRKLTCF YLIRASKNTSRDYVECQDLIRPSTRNSQLAAIEAAKLYEKPVDALILNYYKNFSSKLCCY HFLRSGKALGKSKQELGQLIVGDTRNYRLSFLEGDLIYSKITDDSLKFYLEKFHNKACSS TLIEGGLKSERK-EEVEEVINKKTRNSLLAAVELNHQLRLDITTSVQNYFAMMGSKLCAY IDLNNYKQLRQFFMDISEDLFYEYNKLMLFKDCSSISIFKKHQNEVKSKTNISKNSEFIM IDLHSLVKIETMFSKLPSGLIHDKAVAQLFGKGDNLELFLKHKESTKPKTDYSNCSYFIL VDLNHYDMLKSVMTKYDRDLIHHCNTLELGLIESPISEYNRFKETKKPTTDYSSSSTFIL VDMLHYDVLKDVMQNIERDVIHDSNVFKLKLEDVPIDFYQRHKDSEKSKTDYSQSSIFIL IDLNHYDMLKSIMSKYDKDLIHHCNILELGLIGSSINNYNKFKGTKKSVTDYSSCSTFLL VDLNHYAMLKNVMAKYGEDLIHHCNALELRLFENWINDYNKFKETKKPVTDYSSCSKFIL IDLNHYDMFKNVMAKYDKDLIHHCNILELKLVECSVTDYIKFSETKKSITDYSSCSKFVL IDLNHYDMLKNVMAKYDKDLIHHCNILELRLIESSINNYNKFKGTRKSVTDYSSCSTFLL ------------------------------------------------------------ VDLEHYSQLLTLFSSFERSIDHDVNWARICPETTFSNLFLEYRPTTKPDTNYSCCSHLIL VDLSHYERILAGMDEFPQDLIHDCNKRKLSSSVDYTNLFAQYKHTEKPKTDYSSCAYFIL ADLSQYELPTSFIGSLEENLITVVNNRKFVNQTDNWDVYERFSTKEGAEYDSNPVNELTL PDLSSYDMILSVMKGYPEDLLSECNRTKLAQVSNFIKLFKKYRATEKPKTDYSSCSVFIL NDLKYYENFKALINDSINILIGLVNNQKFKLLFNNWEIYGQFKHLVKELTDFYPAHELIL PDLSQYELPTAFIGGLNDNLITVVNNRKFVNQTDNWDIYEKFSAKEGAEYDSNPVNELTL NDLSKIRIKASTHEIITKSKITLVNNQKFHSLVDNWEIYKLFSSQEKSEFDNDPINELIL PDLSQYDLPVSFVDQLNAQLITIVNNRKFLNTKDNWDVYEKYSVSQGAEFDNNPVNELAL ADLSLVRVHSDYSELLPKEESKLCNLSKLNLRIDSWSNFAKFD-------SVNLIDTYLI YDLKNYKKFAELVQISTNDLVSLINNQKFYFMLNNWKIFNLFKDNRGGEFDNNPANELAI TDISYYDKIKETTSEITASLITLVNNQKFIQTWDNWAIYHKFQPLEKVETDAYSANELIL IDINNYATIKSTFNLFSEDVIHDANTFKLNINDSSSELYMKHKESSKAITDYSSNSVFIL DDLKDYDTVLKMIGYTLKEAIIRVNVEKLKFLVSQITLYQQTEFLKKDPKEYHVGDDFLL NIIRANVEMEISDVLFGITILENYQSQDLYNFETRLWLVVFYLYLGIVPLAYSHFKELNV EIVKDLCKVNLENVITSISLLEGYQAEDPFNYDTRVWLVLLYMYLGLPEKAIAHLETLNI GMVKDVCSPNLKDILLCISLLENYQTKDPHNFDTSCWLIVLYMYLGLVPDAHFHFSNLKI ALVKRVLEPTLDDIILSLSLLENYQMQDPHNYDTKTWIIAIYMHLGLVPLAYSHYLDLKV EIVKDKCNPELKDVLLCITILENYQAKDPHNFDTMCWLIVLYMYLGLVPDAYFHFINLKI ELIKSICNPDLKDILLCITILENYQTNDPHNFDTMCWLIVLYMYLGLVPDAYFHFSNLKI EIVKNICNPDLKDILLCITILEKYQIKDPHNFGTMCWLVVLYMYLGLVPDAYFHFSNLKI EMIKDKCNPELKDILLCITILENYQAQDPHNFDTMCWLIVLYMYLGLVPDAHFYFLNLKI ------------------------------------------------------------ QLVQNLVRITLGNVLTAISLLESYQAQDAYNYDTRIWLIVLYQYLGITPAAHKHYENLKV QIARSLVRLSLENVVASITILENYQAQDPYNYDTRVWLIVCYCYLGLANEAYGHYKELKV RTIVSDLDSSPQNTIKNIVLLKHLLEQDKYNYKLKLWLMKLYSQLNTNDLIFPIYNGLKI KIVESLIVLSLSNVITSVLILENYQNEDPFNFDTRVWLIVLYNYLGCPTIAHSHYTELKI INIILELSKKIETILKNVCIIERLLIDDKSNLNLKLWQIKLYSYLNCQSLVFLHYQKLNI RTIVSDLDSSPQNIIKNIAIIKHLLEQDKYNYKLKLWLMKLYSQLNTNDLIFPVYNGLKI ISVVSSLKEQPRTIVVCIAIITELLKKDEHNYKLKLWLLKLYSQLNTNDQVIPIYQSLKI RSILADLDGSNESIIQSIIIINELLKQDKYNYRLKLWLMKLYSRLNTGDLIFPIYNGLKI CMIDDLRDSSPENIVKHIVHLEHLAKQDSENYRVKLWLLNLYTNINASTKAIKVFHDLKI ISIIIDLDSSIKNIIKNITIISQLLKNDQYNHKLKLWLMKLYSQLNTTNLIMYNYQKLSI MNVVLSLDKSASNIVKNIITLEHLLDKDPQDFKVRLLLLHLYASINCDSLAVHNYNKLRI DLVQKLLDPSLEDILLSLTLLENYQVKDEHNFDTKLWIIVSYMHLGCIPIAYSNYLDLKI IATCSLLSRASINVSKAIILLEHAISRDQHQFYVRLWLTRLYLILGLFPSAEPHYVSLSI KNVQVDSVEYVMYSSTMFPNKQHDYLNIFNIYESLKRLPALLRVSFERKAYSKILGMIEF KNVQNDLVNHWLFTSTFLPNKNYKYCRSLAIY-SLKNMSGFLVASFERRSWCKVPGIVEF KNVQTDSMDYLLFASTLFPNKQSDFYKTFNLYDSLANLPRYIQIAFERSSYSKILGMFEM KNIQNDSMNYLIYTSSLFPSKQDDFLKTFALYDSLERVPQFLKISFERKAYCKILGMFEF KNVQTDSLDYMIFSSTLFPNKQSDFYKTFNLYDSLANLPRYIQVAFERNSYSKILGMLEM KNVQTDSMDYMIFTSTLFPNKQGDFYKTFNLYDSLNNLPRYIQVAFERNSYSKVLGMFEM KNVQTDSMDYMIFTSTLFPNKQSEFYKTFNLYDSLANIPKYIQVAFERNSYSKILGMLEM KNVQTDSMDYMIFTSTLFPNKQSDFYKTFNLYDSLANLPSYIQVAFERSSYSKILGMFEM ------------------------------------------------------------ KNVQNDIVDHLLYTASFFPNKSHPYVALCPIYQSLGGLPTLLKIAFERKSYTKLPGMFSF KNVQNDIVDHLLYTSTMFPNKNHAYIEVVKIYESMENVPQYIRIAFEKKSFSKILGMLEF RMTQHETLNYYLTTTNPSKINLDAWVDIYRFYLSKQEIKESIIQGFDNGVFNKLEGFINF KNLQHDTLDHLLLSSSLIPIKDHPLVQISKVYESASNLPQFIRISFERKSYSKILGMLEL KMIQHNTLSHYLIECFPCKNNLSYLINIYRFYLAEYEINDNIMLGFKKEIFNKLENFLKF RMTQHETLNYYLTTTNPSKINLDAWVDIFRFYLSKQEMKESIIQGFDNGVFNKLQGFINF KMVQHETLGHYLNNV-PTKSTLDELINVFRFFLSTEEIKDTVQNGFEHEVYNKLASFISF KMVQHETLNHYLTHVGPSKDGLKGFVDVFRFYLSKEEMKYTIRQGFENGVFNKLESFINF KMIQNDTLSYKLD-LAPSLANLNELVQVFRFYLSDSEVESFIQKGFEMDLYTKIQDFYQF KMIQHDTLSHYLYTVNPSKQHLTNIVNIFRFYLSSDEVKSSVFQGFEKGVFNKLFSFINF KMFQHESLSHLIVD-TPTKANLQELINIYRFYLADGELNESVSLAFEKEVYNKLESFTSF KNVQNDIIDHLIYSSTLFPQKQHDYFINFNLYESLNRLPQFIRIAFERKAYSKILGMIEF KTIQHDVNSHFLLSSTMFPLSSKLVSKALTLYSNDHESPMLIKHAYNQSTFSKIGGFVEF YRKLEVSTNRWMRSIEKSKLTRLNNNSGMTELLVLESLQHINDNRDKSLFHPYLCPAVLR YQRIFQSFTRWDAMVETLQMSRLLNLDQYKPLIESNTFGENNDNRDFDIFGTDDFQTVLA KDKLMKSYTRWMKILENLQFSRLCNGNLLQKMHEDRSLEMTGDNRDLSILDKDFHDKVLE RSKLERSSSKWMKTCEVLQMSRLCNASLLQKLHQDGKLALMGDNRDWTIFGNDILPDILD RDKLMKSYTRWTKTLENLQFSRLCNGHLLQKLHEDRSLEMTQDNRDFSILDENFRGKILE KDKLTKSYTRWMKTLENLQFSRLCNGNLLQKLHADRSLEMSGDNRDLSILDNNSRDKILE RDKLMKSYTRWIKTLENLQFSRLCNGNLLQKLHGDRSLEMTEDNRDFSILDNNIRDGILE RDKLMKSYTRWIKTLENLQFSRLCNGNLLQKLHEDRSLEMTQDNRDFSILDKDFRGKILE ------------------------------------------------------------ YDQLRRSIMRWHKIGEHLKLLRICNASHLKRIQMELNLNLPEDNRDFNVVFETAFSTLSG NDRLVRSSMRWIKVVENLQLTRVLNGAAMKQLHEYRQAEMHNDNRDFSVLLQSSSSSVTG SKRMQNSISLNFTVAKILQISTILGNYFIHYLKTNEALIVSDDNRDFKSEWNGLEKIDCI YDKLNRSSAKWAKIGERLQHARLFNGDLLANLHSSTLLRLYNENRDFSVL--GLCSIVTE GDNLNKSISKYNLLLEILKISRVTNNYFSNNIKSFISLLNESDNRDNKIHWKGIEGLLDL SKRLQNSVSLNFTIAKILQMSTILGNYFIHYLKTNEALVISDDNRDFKSEWNGLKKIDSI GQKLQNSVSLNTTIQRIIQLSLVLNGYFVSYLKEHEEILEENDNRDYETEWNELKTENLM GKRIENSISLNFTISKVLQTSLITGNYFINYLLDNENLIVSEDNRDFKSEWNGLENTGIL GQRLSNSLTRHLLILRILQISRVLNYNYFYKVVSDKTEILSDDNRDFKTEYNHLEFLHGA GRRLNNSISKQAIVLMVLKFSMVLGTYFVNHLKNNAKILSTDDNRDFKSEWKDETDLLSL SIKLKNSLSRYVLLLQLIKFCRILNNYFSRIVQEH-ELEVSEDNRDYTTLWSFGNTSKLP RDKLERSSMKWLKEIEMLQLAGISNGPLIKKMQESRNIEITGDNRDWSSFNCNILPNIMR KKRLDFSQSRALLVLEQLRMS----EYARQPIGAKQPTHTLMDQRDNKIMWSSDGDRFTA QLHIDETWLYANISQEFMIEAVRAIEPIVK---EMLSNYDITVTERQSFELIHDVYANDG PIHVGTKWLKISITRELIFYSLNERNRFIDDTLVTTNDEELSQHELWTWQLIKLLYNSEA FANLNDASIQLSLVRELIIEALGEKTEQISGLLEKLPQENLTEVESVSFQVFYEIYENDG YLKVNDEWISLNCVKEFMIECIGKKSSMVDEYLKNLSKDLSTKAEVWSFKVIYDIYENDG YANLNEESIFLTLIRELIIEALGEKTEQISALLKKLPSINLTEVESASFLIFFEIYENNG YANLNDESILLAFIRELIIEALGEKTKEITALLEKLPLGDITEVESISFQIFFEIYENDG YVNLNENSILLALTRELIIEALGEKTEQVSALLEKLPSDNFTEVESMSFQIFFEIYENNG YANLNEESILLALIRELIIEALGEKTAQISALLEKLPSNNLTEVESTSFLIFFGIYENDG ------------------------------------------------------------ YMRVDDAYVRLQLCQEFMLEGIGAFSPVVEILAPAQKDFKQTRYEKWAWDVISNVYEHDI YMSVSNDWITLCCVRELMIELVGESSATVDEYLQKADASFVSAVESWSFQVFRYLYE-NG DVPVNDVATKLKLLVYSIVFEDQDASRLLKVFNKITSNAKFSVFDNLLYKLYFNLLKIET YMNPDEAAILAGCLRELMLELFGERDATIDSLLTQRDYTKTTSSESWTFNTIRLLYEQVG GPQYGEEYIKLNYIKELIILNISNSLKLFKLFNKYLNNNLYTVFEKWLFKVYLSVFKYEN SVPVNDSATKLKLLVYSIIFEDQDASKLLKLFNKIISNAKFSAFDSLLYKLYFNLLKIET RIPTDNITLKIKLIIYSLVFESSGIAKLIKAFNRLLGSPDYDPFTTLLNKLYHNLLNMEV SISLKDNTIKLKLLIYLIIFHPGDSSKLFKLYNKITSNEKLTAFDNLLFRLYFNLLKIES EQRKGKEYAKLYYLKELLIVERADIQNMLKAFNKILSNSSHSAFEAHLFKMYLSLFKVDK PLQVNDNLVRLEALKYLIIYEDEIINKYLKQYNKIISNYKALPFDTLVDKLNVNVLRFEQ TVKRGKEYVQLMCAKELLILENTKTTKLIKQFNKALNSEKIAQHEQWTFKLLLNLFKLES SMQVSETAIMINIIKELMIDAVNSTNGKIDELILSTFNNDMTEDEIWSFNIIFDLYKNNG GPKQEETWTRAFTLNWQIQQKLAEFGSLLEELTHVMREAHDTEAEEWQLNVTLRCAELNG SN---VLSILDKIDLAETKGWLQIHSYLQQLTVLKTLDNMKKLKDKVVKQQIKSKLSYVR IDYKAMAMLIEQCPEISKSTWELNHSYLITLATLKSLDQMKRIKDKSVKQLIKTKLKETR EELHTLISKLMKIPLSAKQNWNISHIYLTKITTLKTLDNLKRIKNKEIQKLIKNSLKELR KNLLS-FLQDTSIPADSKSGWKLTHTYLMKLSTLKTLDGFKRIKDKETKKLIKEAIKNLR KNLHDLISRLMKVPINAKQNWMVSHTYLTKMATLKTLDSLKRIKDKEIQKLIKNSLKELR KELHDLISKLVEIPTNAKKNWKISHIYLTKIATLKTLDGLKRVKSKDIQKLIKNSLKELR KELGNLISKLMEIPINTKKNWRFSY-YLTKIATLKTLDSLKRIKDKEVQKLIKNSLKELR KELYDLISKLMEIPIDAKQNWKISHTYLTKMATLKTLDGLKRIKDREIQKLIKNSLKVLR ------------------------------------------------------------ QEEF-LMDHLQKIPDFGLEDWKLVHGYSTVLLTLKTLDGIKRIKSPTLKKLMKDQLQHVR ADHKELIGILREMPEARGTTWLLNHSYLGLLTTFKTLDNLKKIKDKEVRALIKNKLRDLR QSLYNYLQKNLKTDKLKILSGELTQNLTNLVEFIKIVKLLAKRHPSSYMNQLVNLVKPFG LDDNRLLQQIDAIPAVHTSGWRLSHDYHCQLATLKTLDSFKRIKSPQCKAALRNQLQKLR ESIEKFLVKNLKLDKINSLSWEVNYILVNLVDLSKVLTQLSRFESKKICSINKTLISDLK QSLYNYLQKNLKVDKLKILSGELTRNLANLVEFIKIVKLLAKRHSSSYMNQLVNLVKPLA QSLFNFVQKNLKWEKLQPLSSQLNQNLINLAEFTKIVQSLAQRKPSSYLNQILVQCKTIS QSLFNYIQKNLKIDKLKILSSELNENLANLVEFTKVVKLLAKRRSTATLNQLLVQIKPLS ASEIGFLAKNLDFKKIKPKSNQINHILAQAFDFACICPLLVSQPQVKAASNLRAEISAFE QSILNFLLKNLKIDKLRSTSWELNHNLINLVEFIRITNYLVKRYSNPLGQELKTCLDQLA EALVNFLVKNLKLEKIKSVGAGLNRCLFEVLEFIKIYEQISRRNGEILSKAVANVAQEIK ENLTK-LLSAETIPLSNRTMWNLSHGYLMKVGTLKTLDNIKRIKDPVTKSNIKKQLQDLR ERFTKLQELLTNHPLADMEDWSYVHVAFTVVETATSVVRANRLKCDSTYKQVNAVLDHVK GNCDEIFDVMIRDIKKSGGYKDIVDSLGLDEKILVDSINTVRKVTRNL------------ DTCVPMFKSYADMVQSVGNGNKLLETVSKLTGDIATEITQMSKSIRNI------------ GCCDTIFKEYSNAITQKGEPTKLLKELDESTKNIKNSLLNIQKNVRNL------------ ESCDSLYQAYSLKLTNNSGNSELLKPLGLGVTGLQNSLLTVQKNVRNL------------ SCCDDVFKGYSKALVKKDECGNLLKELDENVKNIKNSLLGIQKSVRNL------------ ACCDDIFKEYSNDLTQNSESSKLLKELDESIKTIKNSLLSIQKNVRNL------------ GCCDDIFKEYSNTLVHNGKYSSLLKELGESIKNIKNSLLSIQKNVRNL------------ GCCDDIFKEYSNALVQKGEYSKLLKELDENVKNIKNALLSIQKNIRNL------------ ------------------------------------------------------------ GRCSSIFDEYAEEIATCSVDIEFLSRFGPASESATQSLREVFKALRNL------------ GSCDEMFQEYAEKVLKNSIDLALLAGLGATVDRIVAAIKDTSKTVRNL------------ KKNLKLVQRQHEIIDSMDFEPPISVDISQTKLEIKSSIEDCVVALLNS------------ ASCQDQFSRYMQEIKECKPDTDLLSSLGINEHQIHKAILMVLKSSCNL------------ SNCKKLQVNKLNELKNFDFDKNLNLDANETFQIIENSIYEA--SISNL------------ KKDLKLVQLQHELIDAMDFDLPFAIDISQAKLEIKNSIEDCTVALLNS------------ AKKEDFVKRQLASIDLSGDDFPFDFDIQPILNDIKNSVSASTKSILNS------------ KKDLKLAEKQIELIDEMNFELPFQIDMDPIKQEIKHSIIDSTNILLNS------------ EKQKKLFRKIKSSNSFEDLPQDFSDTLEDIIEGVRSSSLKLSR----------------- RKKINIVDSELKQLEVRDFPIDITSEIDDSFGLLHESISESTGFYRNL------------ N--SKLTDSTLSEID--------ADDVPEVVEMIKKSLKES--SYKKC------------ GSADDLYKSYSNKIKSNDETNKLLQDLGLQLSRITETILMVQKTVRNL------------ KGEVKNLRSKAREQDELLGDWALKVKMADVIEGIHSSRDKVMTGVRAG------------ ------MQG-----------YEKLVNSHE-FAQLTTELAQYPKKLIS------W---EKL ------MED-----------DLNLLGDQK-LSEFSLLICKYPKSLHH------W---ENL ------MDK-----------YTALINDGK-FSTLTLNVSRYPKSLVY------W---EKL ------MDK-----------YNSLLDDEK-FSSLTLQVTKFPRELSN------W---EAL ------MDK-----------YTALIHDEN-FSTLTLNVSRYPKSLAY------W---EKL ------MDK-----------YTALINDKK-FSAFTLNVSRYPKSLAY------W---EKL ------MDK-----------YTTLINDEN-FSTFTLNVSRYPKSLVY------W---ERL ------MDK-----------YTALINDEN-FSTLTLSVSRYPKSLVY------W---ERL -KHLSVMDR-----------FSRVVSDPA-FSELTLEVARFPKSLEG------W---ERL -------------------------------MNVSPKVSKFHKTLAY------W---EKL ------MNV-----------SLDIVLDDS-FSQLSLKVSQHPKSLVR------W---EEL ----------------------MSLINKQ-WSSISTELVQDPQNFEL------W---QSL ------MDD-----------SLDEILDDR-YGEISLKVSQSPLALNN------W---EEL ------MNK-----------LVKEFENPT-WSDISTQLLKNPYNLKL------W---EKL ----------------------MSLINKQ-WSRISTELIQDPQNLEL------W---QSL --------------------MSQLKK----WSDISTELIKDPDNFSL------W---QRL ----------------------MSLINAK-WNKISTELIQDPNNLDL------W---KEL --------------------MSDLSQINPDWHSVSIELLKNPFDLDL------W---QQL ---------------------MDTIINQE-WSRISTELVQNPDDLNL------W---QLL -----------------------MEAEQSGWGRISAALVENPESLDL------W---EKL ------MDP-----------FNSVVSNEK-FSKLTLNVINYPKSLEH------W---ENI ------------------------------------------------------------ LVLI-NTHIGNVNKAIDAKLY-KLLKTTYTDMLYYFPLLENYYIDYALLEYKLGHFKSVH LNHL-LLKASPISKSINKDLL-QLVRSTYESLLYQFPFLENYHVEYGLLEYKLGNFGKFH LNHI-IHTSTPICKSIEPQLL-ELIRYTYSSMLNEFPYLENYYIDFALLEYRLGNVSRSH LNHL-ILFSSPLNKALDPQIQ-KLIRNTYTSMLFYFPYLENYYVDYALFEYKLGNVSKMH LNYI-VKASAPICKSTEPQLL-KLIRCTYSSMLNEFPYLENYYIDFALLEYKLGNVSMSH LNCI-INASTPIYKSTEPQLL-ELIRYTYSSMLNEFPYLENYYIDFALLEYKLGNVSTSH LNYI-VNASTPICKSTEPQLL-ELIRYTYSSMLNVFPYLENYHIDFALLEYKLGNVSTSH LNYI-VKASAPICKSTEPQLL-ELIRHTYSSMLNEFPYLENYYIDFALLEYKLGNVSTSH LNHL-TTVASPLNKNIDTRLY-QLLISTYQSFLCQFPYLENYYVDYALLEYRLGHLNKMH LNYL-LKLASPLNKSIDRQLC-KLIRYAYESMLLQFPYLENYHVDYALFEFKLGSTAKMH LNYL-IGKVTPLNKAIDKQLA-NLIRSTYESMLSHFPFLENYYVDYALFEYKLGDIKSMH IEAAEWNEKRGINKSTSEEEL-NVLRTSYNSFLEKFPFQFKYWIRYAEWEFKLGNTSTAE INYL-IDKASPMRKALNTQLV-QLIRQTYKSMLAYFPFLENYSVDFALFEYKLGNIKEMH VEAAESNNGNRINKISSRQEV-DLLRASYENLLNKYPLLVNYWIRYAEWEFKLGNTQIAN IEAAEWNEKRGINKSTSEEEL-NILRTTYNSFLEKFPFQFKYWIRYAEWEFKLGNTSTAE IEAAEYNDKQGICKATPKTQL-LILRTSYVKFLEKYPFMYKYWVRLAEWEFKLNDTERAI ISSSETIDKKPITKSSSSEQI-KLLKTSYESILNKYPFEFKYWMKYANWEFKLGNTNQAN VHCATYSNGVVLDKTASDAQV-HLLRVSFDSLLHQYPLLSKYWTAYAEWEFKLGFIERAN IKAAESNTKRGITKSSGFEEI-DVLRVSYQKLLQKYPLLYNYWIKFAEWEFHLGDTDRAN IREVERENGVPISKVSSDEAV-EILRTCYNAFLEKFPLLVHYWIRYAQCEFRLGYHQKAI INYL-IDEVSPINKKLDKKLY-KLIVTTYESLLFNFPYLENYYIDYGLFEYKLGNISNVH ------------------------------------------------------------ TIFKEALAVHNNRSLLLWKNYLQ-ICNKIVIDQ---RQLLKKYSEAEDYIGVHYLSGEFW AIFENALQYFNNRSLLIWVEYLK-ICNKIMPSD---KQLFQKYAFAESYIGLHFFGAEFW KIFQRGLQAFNQRSLLLWISYLK-FCNDVVLNQ---KQLFKKYEMAEEFIGLHFFSGEFW KIFKHALNVFNQRSLLIWVSYLK-LCNEVIPDS---KQLFKKYELAERFIGLHFLSGEFW KIFQRGLQAFNQRSLLLWTSYLK-FCNNVISHQ---KQLFKKYETAEEYVGLHFFSGEFW KIFQHGLKAFNQRSLLLWISYLK-FCNNVVSNQ---KQLFKKYETAEEFIGLHFFSGEFW KIFQRGLQAFNQRSLLLWTSYLK-FCNNVILNQ---KQLFKKYETAEKYVGLHFFSGEFW KIFQRGLQAFNQRSLLLWTSYLK-FCNNVVLNQ---KQLFKKYETAEEYVGLHFFSGEFW RIFQHGLAVFNNKSLSLWTSYLK-ICNEVVPKS---KQLLEKYELAEDHIGMHFFAGEFW KIFQKALDIFNQRSILLWVEYLK-LCNEVVMSD---KALFKKYETAERYIGLHFYAGEFW KIFQMGLQKFNNMSLLLWTEYLK-ICNHVVMSN---KQLFKKYELAESFIGLHFFSGQFW QIYLRGLNTQLSHCIELWISYLN-FKINTINDN--ISEILQKFEAARDLIGFHFFGFEFY ETFTTALEKHNNSSLLIWVEYLK-ICNEVVSNN---RQLFQKYELAESFIGLHFYSGEFW EIYEKSLLNL-SYSIELWISYLN-FKIKTIDSD--VKKVLSVFESARSKIGYHFHSHEFY QIYLRGLSTQLSHCIELWISYLN-FKINTINDN--ILEILQKFEIARSLIGFHFFGFEFY LVYRLAFQHL-RYCIELWCAYLQ-FRVDTISNN--VEEVLGLFEEARGLIGNHFYAYEFY EIYLKSLDIS-PWCIELWIDFLK-FKIETISNN--IDSILKLFEKSRSFIGFHFYSSEFY TVYLKGLTYV-GFDLSYWLDYLR-FKLRVIGDD--TQEVLELFEEARLRIGFNFHASDFY QVYQSSLKHL-SYSCEIWTSYLN-FKINTSNGN--LDEVLGLFELARRKIGYHFHAYEFY IVYERALVHL-RASIELWTNYLQ-FRVDTISDN--VEEIAQLFETARKTIGRHFYAHEFY KIFKNGLKVFNQKSVLVWVSYLQ-LCNEIVTDD---KALFKKYEKAEQYIGMHFYSGEFW ------------------------------------------------------------ EMYLEVLKERC----NVKI-RYYSTLRKVLEIPLHSFSKFYAIWLKHIDDDITDLSKLK- HMYLNEIKLRC----KTPQ-HYIRTLRKVIEIPLYEYSSFYDLWLQTIE-DVKDLSQLR- DLYLEQIQLRC----VSSK-RYWSVLRKILEIPLHSFAKFYALWLHQVD-DITDLKRLS- DLYLEQLQERC----ANNG-RYLIVLRKILEIPLHSFSKFYAIWLRQID-SINDLSQLC- DLYLEQISSRC----TSSK-KYWNVLRKILEIPLHSFSKFYALWLQRID-DIMDLKQLS- DLYLEQIQLRC----KAFK-RYWSVLRKVLEIPLHSFSKFYALWLQHLD-GIMDLKQLT- DLYLEQIRSRC----VSSR-RYWSVLRKILEIPLHSFSKFYALWLQHID-EVMDLKQLS- DLYLEQIRSRC----TSSK-RYWNVLRKILEIPLHSFSKFYALWLQNID-DIMDLKQLS- QMYLEQVKLRS----NQQQ-RFFSILRKTLEIPLYSFSHFYAVWLRCVD-DIQDLSQLK- EMYLEQIRQRC----KLPH-RYVTILRKVIEIPLYDYSVFYSLWLQCIQ-DVKDLRQLK- EMYLEQVEMRC----KTPN-RYLIILRKVLEIPHYSYSNFFAKWLQCIE-DIRDLKQVA- ELYLSFLDNYKNDNNEFEK-KYYILLRIILEIPIYHYGIFYKKWFDLIDNDEKLAKQIA- EMYLEQVQLRC----KTYT-RYLVILRKILELPIYSYSKFYALWLDAID-NIKDLKQLA- SLYLSFLQNYANDHNGFKL-KYYVLLRIIIEIPIYHYGIFFKKLFTAIN-EKNLTMEVV- ELYLSFLDNYKNDSNEFEK-KYYILLRIILEIPIYHYGIFYKKWFDLID-KLLKDEKLAR NMYLSFLETYSTEENDFKR-KYYILLRIVLEVPLYHYQHFYSKYMKLIK-DVADPQKVTL ELYLEFLDNYKNDNNEFEK-KYFILLRIILEIPLYNYGFFYKKWF-----DLIDKLSKD- LLYLSFLRSYATKDNGYYE-KSIWLIRSTVEIPLYNYSLLFREMM-----EVINPKSLTF KLYLSFLENYQTETENFKL-KYYVLLRIIVEIPLYHYEYFYKKLFDTFA-EIGNDEKRAN QLYLSFIKSYAT--NDPER-QYHILLRTIIEQPIYHYNLFAKMFFSAI--SNLNSTTIG- ELYLNLIKER-----SISKIRYFSMLRKILEYPIYSFSKFYAIWLKEID-NVRDLKQLS- ------------------------------------------------------------ ---LFVSEIDIREKLLVDINY----------------------KGRRGPYIQKAKEQLKK ---FYAEDKELWKKLKIDTQL----------------------NGRRGPHLQVAKKALKK ---QLTSEDELLKKLKVDIKY----------------------SGRKGPYLQEAKKKLKK ---RIAPQNDLLNKLKIDVKY----------------------NGRRGPYLAEAKTLIKK ---QLTSKDELLKKLKIDINY----------------------SGRKGPYLQDAKKKLKK ---QLTSEDELLKKLKIDIRY----------------------SGRKGPYLQEAKKKLKK ---QLTSKDELLKKLKIDITY----------------------SGRKGPYLQDAKKKLKK ---QLTSKDELLKKLKIDINY----------------------SGRKGPYLQDAKKKLRK ---KSAPKEDLIKKLKIDIDT----------------------GGRKGPRLQEAKKLLRK ---WFAPCSELWKKLKINVCL----------------------TSRRGPELQEAKAQLRK ---LFAPQEELWKRLKIDIFL----------------------GSRRGPHLEDAKKQLKK ---PYIAPANEIATLASKKN-------------------------------TSIFNELKK ---AMVPEGDLSKKFKIDVKD----------------------PGRKGPRLQEGKKLLRK ---GYLVPEKELPQF------------------------------TNIKDMKTVSLKLKK QIVRYIAPANEIATLESKKN-------------------------------TSIFIELKK KDLKYIVPERDLHKDR-----------------------------------KKLLLSLKK ---------EKLAKDKLQYIL----------------------PNDNYKIDKKLFAELKK NNLHLLIPDSQLKTWKTQTK----------------------------NNLSTISKRLEK ELVPLVVPEKELKNYKTSEN-------------------------------KQLALHLKK ---YIV-PPKAIRSYNGDFR--------------------------------QASIKLKK ---LFAPRDELKKKLKIDIKF----------------------KSRKGPYLFECKKKLKK ------------------------------------------------------------ YTQDLYTIVQYQVIERYSLFESKLTVQYYTSCDELVSA-----DQQNIWDKYLDYVIN-- VSKELFLVVQYEVMEIYELFESKITKRYYMSAEELIPH-----QEIIVWTKYFEYIRE-- VTKEMYMVVQYQVLEIYSIFESNIYTNYYTSSETLVSS-----DEIEAWIKYLDYTIN-- STKELYTVVQCQVLDIFSLFESKLYTHYFTSQGTLISS-----DEISTWEKYLEYTIN-- ITKEMYMVVQYQVLEIYSIFESKIYINYYTSPETLVSS-----DEIETWIKYLDYTIT-- MTKEMYMVVQYQVLEIYSIFESKIYINYYTSPETLVSS-----DELETWIKYLDYTIK-- ITKEMYMVVQYQVLEIYSIFESNIYTNYYTSPETVASS-----DEIETWIKYLDYTIN-- ITKEMYMVVQYQVLEIYSIFESNIYINYYTSPETLVSS-----DEIETWIKYLDYTIT-- FTLELYLVIQYQVLEIYSLYESKIQTRYYVSPETLIPT-----HELELWQKYLEYTVN-- VTKELYMVVQYQVMEIYNLFEGKLVTHTYTSPSTLIPH-----EEITTWTKYLDYTAT-- FTKELYMTIQYQVLEVYNLFEIHLKTHYYCSPESLIDQ-----NQVLAWCKYLDYTET-- RFTDAYIATQYHSFELYE-FEKKLIPKNNKNPQ--QDNDLRSRQELDAWMSYIDYLEI-- STKELYMVVQYRVLEIYNLFEINLKTHYYMSAEALVEH-----NEIETWWKYLEYSIT-- IFTDVLITTQYKVFQVFY-FEKKITRPYYDVSY--LSN-----QEITNWNNYLNFIEL-- RFTDAYIATQYHSFELYE-FEKKLLPKNNKNTQ--QDNDLRSRQELDAWMSYIEYLEI-- TFTDAYATIQYKVYELYH-FERKFSRQYNDVKL--LSR-----QQLEAWEEYFEFLEL-- RFTDAYISTQFHTFELYN-FEKKLITK---RKT--MSI-----QDIEAWLGYIEYLEI-- TFTDAYVVNQYKSYQIYS-FEKNIVSAYYDNHV--LST-----NQIESWKQYLDFAEQ-- TFVDAYLTTQFKVYELFN-FEKHITRQYYDTSS--ISS-----QQLENWDMYLDFLEL-- LFTDVYITTQAKTHQIYS-FERHFQRQYFDQTF--IPQ-----AQLKQWHNYLSFLEL-- ITKEMYSVIQFQVLEIYSLFESNLSIQYYVSPDKLIPT-----SEIEKWEGYIDYSIN-- ------------------------------------------------------------ ----LN-------IAP------LTQTTFQRALVCLAHYDFIWIKYAQYF----LKVEE-- ----KK-------ISD------LIKLQFQRSVLPLAHYDHIWLQYANYL----IDDLN-- ----FQ-------TDS------LTHLNFQRALLPLAHYDIIWIKYCQWL----ITAKN-- ----LN-------VKP------LTHLNFQRALIPLAAYDIVWIKYAQWL----IEKND-- ----LQ-------TDS------LTHLNFQRALLPLAHYDLVWIKYSKWL----INSKN-- ----LQ-------TDS------LTHLNFQRALLPLAHYDIIWIKYSQWL----INAKN-- ----LQ-------TDS------LIHLNFQRALLPLAHYDIIWIKYCKWL----IHEKD-- ----LQ-------TDS------LTHLNFQRALLPLAHYDIVWIKYSKWL----INSKK-- ----LK-------IDD------LTHLNFQRALLPLAHYDIV------------------- ----LR-------IYP------LTSLNFQRAATVLAHYDVVWLKWANWH----AEREG-- ----NR-------VSQ------QVRLNYQRALIPLAHYDTIWLKYANWL----IDKED-- ----KQY------PIK------FIELVYYRFLYNARNYPQTWSKFADYY----IYHA--- ----NG-------IDK------VTQINFQRALLPLAHYELIWLKYSFWL----IQSAG-- ----NY-------PLD------YVILSYERCVLTAANYSRFWIRYANFF----INSM--- ----KQY------PTK------FIELVYYRFLYNARNYPQTWSKFADYY----IYHG--- ----KNY------SQQ------LIEMNYYRYLYICGNYPRSWINFANYY----IYHE--- ----KQY------PNK------FIELVYYRWIYKETTNEVIWLKLADFY----IYHN--- ----NH-------TFS------YVCQLYERSLVSTAKYCTIVLKFVDYL----VSQK--- ----REY------PND------YIIFTYERCLIPTASYARFWTKYSDYY----INQGN-- ----NF-------PHQ------HTIQVYERCLLITAPYPEFWLRFAEFH----ISQD--- ----TR-------NEQ------LIEINFQRGLIITANYDAIWIKYSKWL----ISSQK-- ------------------------------------------------------------ --DLYSAKNVLLK--SLQYALRKGRIIELLTVVLVKTNELYFL------DKLFKVWEDSL --DFIGAKNVMLQ--ALSYVHKRSRIVTMLSSVLIRLGQISEL------HQLYDDISLAF --DLVGAKNVLLT--GLKFSLKKTKIINLLYSVLCKLNDYELL------RTLFEKIESSY --DLVTAKNVLLR--ALSMSLKKTSIMRFLYSILSKMNQFDTL------SRLLEQVETSY --DLLGAKNVLLM--GLKFSLKKTEIIKLLYSVICKLNEYVLL------RNLLEKIESSY --DLLGAKNVLLT--GLKFSLKKTKIMKLLYSIICKLNDYELL------RSLLEKIESSY --DLVGAKNILLT--GLKFSLKKTKIIKLLYSVTCKLNDYELL------RNLLEKSDSSY --DLVGAKNVLLM--GLKFSLKKTKIIKLLYSVICKLNDYVLL------RNLLEKIESSY ------------------------------------------------------------ --DYVSAQNVLVK--GLQLSNRKARILSRLAVVMIRNGEYSEL------NTIYDDLITLY --DFLTSKNVLLQ--GLQMSHKKAKLLDRLSSVLIKLGDYSTL------TQLYTQVEHSY --KFNKARKILTD--GVKY-VDDYKLLIKLVDLEIFLKNYQRA-------------I--- --DYVSAKTVLVQ--GLKVSHKKAKILEKLSAVMLKMSRYPEL------VEIFEQTKKAY --NYTIAKEILHR--GLNFD-NSYKLLIKLVDLELFTGDYLKA------RDLILSHV--- --KFNKAKKILTD--GIKF-VDDYKLLIKLVDLEIFLKNYQRA----------------- --KYNMARYILSR--GWQY-LGNHEILIKLVDIEIFLKQFQRA------KDLITSYL--- --KFNQARKSLND--ALRYVNNDYKVLIKLVDLEIYLKNYQRA-------------I--- --KFSMCRQILRKFISVNPSRNDVKLLIRLVDLEVYLGYFERA------R---------- --HLKAAE-VLVR--GYNYS-GQHSLLLKLVDLQIYLHNFTKA------RDMILAFI--- --RMLQAVEVLTR--GMVYC-ASYKLLVKLVDVELSLKNYTRA------RDILTEYV--- --DLVSAKNILID--GLSMSLKKSKIIKMLFDVLVGLNDYDSL------EYILSQMEK-F ------------------------------------------------------------ -PEGCEDIEDFQSFWNYIEFQVYLHRNKNQSRYE--DSNSNAFLSDD-ILSKIM------ -SNDLTTSDDFEIFIDYIQFNLFLSSANSKSRFS--GLTNNIEFSDN-LLDVLM------ -AENIENVDDFEIFWDYLQFRIFYQNSVSSSRYS--DSNLSGLLNKE-LFDKVW------ -LNEIEKSDDFDIFWDFIQFQIFMSKTQGQSRYS--NSQTLSLLPPK-VFDKII------ -SDNVENVDDFEIFWDYLQFKTFCQNSLYSSRYS--DSQSNGLLNKE-LFDKVW------ -SGNIENVDDFEIFWDYLQFRVFYQNSVSSSRYS--DSQSGGILNKE-LFDKVW------ -SDNIENVDDFEIFWDYLQFKTFCQNSLYSSRYS--DSQSSGLLNKE-VFDKVW------ -SDNVENVDDFEIFWDYLQFKTFCQNSLYSSRYS--DSQSNGLLNKE-LFDKVW------ ------------------------------------------------------------ -QGKLDAL-DLQSFLDYVQIKVFLTQPISQSRYK--SANDDFLISEE-LMEIIL------ -SDGIQDTDDCELFLDYLQYKIFLTRNISQSRYNGGDDKDSLLLGHE-ILDTIM------ -----------NLLISYIQY------------------NSNVPIPIR------------- -DEKIEESDDFELFQDYFCFVLFMERCFEAQPE-----ATTGKIDTD-PIKLLM------ --------------------------------------KANKLIPIK-VYEKMISI---- ----------INLLISYIQY------------------SSNVPIPIR------------- --------------------------------------KYSISVPIP-IYEKLI------ -----------NLLIGYLQF------------------NTNIPLVIQ------------- -----------DIVVNYLALNKTAPNC---------------------IYSKLF------ --------------------------------------KTNASVPLP-IYEKLI------ --------------------------------------KESAATPIP-ILEKLL------ -SINIVDIDDFEIFWDFIQFKMFLANNSLKSRYS--ESQKNSFLPEN-IFTLIL------ ------------------------------------------------------------ -HRLEYQEKRQGHG-------------------------IILSYLVDLQTK-----SNTQ -KKASKEDDHNRQY-------------------------ILLNMVNEMYER-----FPRA -KRLSLKENKTGQE-------------------------ILLNSLIQFYTK-----DTVA -KRLSYGTERSGQE-------------------------MILEALLQLQTK-----ENTQ -KRLSCKEKKSGQE-------------------------ILLNNLVQFYSK-----DTVE -KRLSCKEEKSGQE-------------------------ILLNNLIQFYSK-----DTVE -KRLSYKDEKSGQE-------------------------ILLNYLIQFYSK-----DTVE -KRLSCKEKKSGQE-------------------------ILLNNLVQFYSK-----DTVE ------------------------------------------------------------ -KRLS-SEDEAGHR-------------------------ILLPLLNQMYQR-----VPRD -KRLSYGKGKSGQE-------------------------LLLSMLKEMYGR-----IPRI ------------------------------------------------------------ -KRLSYGEHKSGQE-------------------------ELLHMVCQSYQR-----FSRK -ERLMNPTDDEYLV------------------------NLVSEIIKQTNNAWFFKVILSY ------------------------------------------------------------ ----------------------------------------NVEHIL----------NNSD ------------------------------------------------------------ -EVESMFHFEGDDE-------------------------YLSGLALQIIRQ-----TKSL ------------------------------------------------------------ -------SVESLFH------------------------------------------TQDS -NRLKYEGSKEGQL-------------------------LLLHYLVQLQDK-----DNTK ------------------------------------------------------------ LIEDKVFKEIIRKDLTFLIGGGLFWYLYSKLIFFD-----------SERSYLERRGYIIE LVETKVYQHIINSKWKSFLENPKFWYLYCSLVWYD-----------NNITYLKRRKHIIN FVEKNVFQKILTSNWAYYLQNGMFWSCYCRLIYFD-----------TSRSYLEKRQYIVK LIEEQIFQYLINTNIEYYTKNAKFWSLYCHLIFFD-----------PSKSYLERRAHIVN FVEKNIFQKIIEFGWEYYLQNGMFWNCYCRLIYFD-----------TSRSYLDKRQYIVR FVEKNVFQKIIASGWDYYLQNSTFWSCYCRLIYFD-----------ASRSYLEKRQYIVK FVEKNVFQKIIAYGWEYYLQNGTFWHCYCRLVYFD-----------TSRSYLDKRQYIVK FVEKNIFQKIITSGWKYYLQNSIFWNCYCRLIYFD-----------ASRSYLDKRQYIVK ------------------------------------------------------------ LLEKKLFQRIISSNWSQFLSSGYFWYEYCHMVWFD-----------TGRSYLERRKYITK QLENRIFKPIIEQNWDYYLNNGKFWYEYCHCVWYD-----------PKRSYLEKRKCIVR -----------------------------------------------------DKVHQVK MLEEKVFRPIIDQNWTFYLNSEKFWYEYCLRVWND-----------QESSYLEKRRHIVS LLSSQVTLQLFESFESSFKSSFIYWSSWLFFNKKI-------------DADNAAILAKSL -----------------------------------------------------DKVHQVK DHLLDLFKEVISE-------TRNDWF-FSVLTYYS--------------IDKQKKLKFME -----------------------------------------------------EKVMQVK DVLSRISTRMSESMLARLLSCLNAEYDELDSEMKR------------LPMFSKERLSIIR ------------------------------------------------------------ TKMRNLFLQIFKESD--HHRVSELLNYYTLPEELK-----------SEIRSHFNLELNTK IIENKVFKQIIKDNLEYYINDGTFWTLYSQLIYFD-----------PSSSYLEKRRSIL- ------------------------------------------------------------ RVWSQIPKQYYERVSTKLLEFC--------ETYLPEDV---------------------- DIIPSAAK-YGKAVLSEVELFI--------SNYLPDDM---------------------- TIWPQIDKKLAQTVLPSLTEFC--------QSYFPEEL---------------------- NIWKKASKYSLED-NSSLHKFC--------ESYLPDDL---------------------- KIWPQIDKKFAQSVLPSLTEFC--------ESYFPEEM---------------------- TIWPQIDKKFAQSVSPSLAEFC--------QSYFPEEL---------------------- RIWPKIDKKSAQNVLPSLTEFC--------QSYFPEEL---------------------- KIWPQIDKKFAQSVLPSLTEFC--------QSYFPEEM---------------------- ------------------------------------------------------------ EIWPQAARYRNDGICNALQQFA--------ASYSPDDL---------------------- DIWPQASK-YQGTVKDSLKEFC--------DSYLPEDL---------------------- QLIDQK------------------------------------------------------ NIIPEAAKQGPSALKGLL-VFC--------ETYLPEDL---------------------- QFLNDDDKLKINKINNYKKIAS--------PRFDEEYD---------------------- QLIGQE------------------------------------------------------ EMSEFKDQ----------------------QFYK-------------------------- KLIEK------------------------------------------------------- SAYPNQKKLED------------------------------------------------- ------------------------------------------------------------ DEVNFDAKFHQSLIGPLHN----------------------------------------- NLWKTGVP-HTDSVKELLSEFC--------FKYLPDDI---------------------- ------------------------------------------------------------ ----DIVYDMR-----------KEQ----------------------------------- ----ELFTEAY------------------------------------------------- ----DTLEEMF------------------------------------------------- ----DAFEDLF-------VV---------------------------------------- ----DTLEEMF------------------------------------------------- ----DTLDALF------------------------------------------------- ----DTLEEMF------------------------------------------------- ----DTLEEMF------------------------------------------------- ------------------------------------------------------------ ----AILSELF------------------------------------------------- ----DTFESTF------------------------------------------------- ------------------------------------------------------------ ----ESCYKIG-----------SCN----------------------------------- ----TLLDSFA------------------------------------------------- ------------------------------------------------------------ ----KAMQVLL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----NIERFL------------------------------------------------- ------------------------------------------------------------ ----DNLDDLF------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TN ----------------------------------------------------------AE ------------------------------------------------------------ ----------------------------------------------------------TE ----------------------------------------------------------AE ----------------------------------------------------------AQ ----------------------------------------------------------TE ------------------------------------------------------------ ----------------------------------------------------------DS ----------------------------------------------------------N- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------A- ------------------------------------------------------------ ------------------------------------------------------------ QGQMKVPI---------------------------------------------------- KA---------------------------------------------------------- ------------------------------------------------------------ EP---------------------------------------------------------- EA---------------------------------------------------------- EP---------------------------------------------------------- EP---------------------------------------------------------- ------------------------------------------------------------ NSKSE------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAPSLCDS-------------------AFARKGVDALISYATNQDSNN------ ------MPIELDTD-------------------GATTKALRALTKQCEVDPKLANDT--- ----MVDQVDVIRS-------------------ELAEKALNALILQCRENASLQNDK--- --MQASLELDQSKN-------------------GLPRKALVSLIAHCETDPKLSNDK--- ----MVESNDIIKS-------------------GLAEKALKALILQCEENPSLKNDK--- ----MFDQANVIKN-------------------GLAEKALISLLSQCKENASLQNDK--- ----MVEQANIVGS-------------------KLAEKALNALIVKCKESTSLQNDK--- ----MVEPSNILKS-------------------GLAEKALNALILQCKENASLQNDK--- ------------------------------------------------------------ ------MDAPIDAE-------------------GLASKALNALLKQCAADPALSRDA--- ------------------------------------------------------------ ----MKSSEFILGE----------------TAYKNAKKSLQSLIKQYNNQPETINTPPPP ------------------------------------------------------------ ----MVSSFILGQS-----------------ALADGTKSAKSLASHIGKENGPTHHE--- ----MKPSEFLLGD----------------TAYKNAKKSLQSLINQYSTQINTSTNDD-- ---MKMSLDFLLGD----------------EAQLQTQKSLRALKQHLKKTISTESS---- ----MTPEQFILGEKAY----------------KTAKKSLLSLKKHHENDSKT------- ----MSFVLGTEAR-------------------EEAKKSLRGIIGHIADEAQKNG----- -----MSNTFSLGPDAY----------------KVALKSLKALKSQVNVENGQGDIGM-- --MGEQNKFHLGSE-----------------AEAATQKSIRALVAHSRKAGKSE------ ----MASKLNLNKD-------------------PLVAKAVTSLVNHCENDPKLKNDK--- -------MKLTQKP------------------------AIKALFKSAKQELTEDPNQRI- ---------------DIQLIIHTEKKLGIKKDYIPRVIPLKHNKMSKVKDMRILLITKDP ---------------SIHLIINTQQPVGIRNDHVPRIIPLKHSQMKSANDVRILLICKDP ---------------SIQIIINMGKKMGIKKDNIPRIIPLTKCKLFKPRDLNILLITKDP ---------------DIQVVINTGKRMGLKKDYIPRIIPLTFCKLYKPKDLRILLITKDP ---------------DIHIIINTGKKMGINRDNIPRIIPLTKYKLFKPRDLNILLITKDP ---------------DIHMIINMGKKMGIKRDNIPRVIPLSRCKLSKPRDLGILLITKDP ---------------DIHIIINMGKKMGIKRDNIPRIIPLTKCKLFKPRDLNILLIVKDP ---------------DIHIIINMGKKMGIKRDNIPRIIPLTKCKLFKPRDLNILLITKDP ------------------------------------------------------------ ---------------HVQLVINTKKPMGTKNDYVPRIIPLQHCRLQKPSSLRILLVVKDP ------------------------------------------------------------ DDDDDDDETSTPIPTAIHLVISIKIPLSRKKDYIPRIIPISYK-LDDVTNKSILLITKDP --------------------------------------------MHKPSELRILLITKDP ---------------AVYLIINTKIYLTKIKDYTPRIIPLSKG-LDKLENKSVLLVTKDP ---STHISSTNNQGMAIHLVISIKIPLSRKKDYIPRIIPISYK-LDDITNKSILLITKDP ---------------PVYLTINVKTKLSSQKDYKPRVVPLTHK-LDKITNKSITLITKDP ---------------SINLIINIKIQLVKTKDYRPRIVPITYK-LDKVTNKSILLITKDP ---------NQSHHEPIILVLNTNIYLVKEKDFTPRIIPVTHK-LHKIDEKTILLITRD- ---------------PVYLIINIKIPIVRAKDYTPRIIPIAHK-LDKLENKSILLVTKDP ---------------PIYLIINTVKPMVRKKDYTPRIIPVTNK-IGRLQDKSVLLVTKDP ---------------NIHITITMSKKPAVSKDHTPRIIPLSCCKLNKPKELRILLITKDP ---------------PVHLTVTTTSKTGMNNISVPYVIPLHHKIHKSISQAKILLIVPHP ANKYRDVLTSNELTS---DTFKEIISVKNLKRRFR-GSKLTSLYKEFDMVVADFRVHHLL STLYRDSLTKEKATA---ELFKEIISVKKLKQRFR-GKKLKELYNEFDMIVADYRVHHLL STLFRETLTKDEHTS---ELFKEIISVKNLRRRFK-GSKLTQLYKDFDLIVADYRVHHLL STLYRETLEKDEATH---EMFKEIITVKNLKRRFK-GAKLNHLYREFDVIVADYRVHHLL SALYRETLTKDEHTS---ELFKEIISVKNLRRRFK-GSKLTQLYKDFDLVVADYRVHHLL STLYRETLTKDEHTS---DLFKEIISVKNLRRRFR-GNKLTQLYKDFDLIVADYRVHHLL STLYRETLTKDEHTS---ELFKEIISVKNLKRRFR-GNKLTQLYKDFDLVVADYRVHHLL SSLYRETLTKDEHTS---ELFKEIISVKNLKRRFR-GSKLTQLYKDFDLVIADYRVHHLL ------------------------------------------------------------ STPYRNALKADSATS---ELFADIISVKRLKTKYR-GAKLSELFRQFDMVVADHRVQHLL -----------------------------------------MLFREYDLVVADYRVHHLL STPYRSKLMIKDSPTE--DLFSDIISFKKLKSMINSSTNNKKIFKNYDIIVCDHRIMKFL STLYRKTLTEEPSTA---ELFKNIISVRTLKGKYR-GSRLSKLFKEYDLVVADYRVHHLL SLPYRDALTKKDSPTE--DVFNQIYTLTKLKHISKDPKKLTKLFKEFDIIVADNRVHKFL SIPYRSKLMIKDSPTE--DLFLDIYSFKKLKSMINKKQNLIKIFKNYDIIVCDHRIMKFL SHIFRDALTIKDAPTE--DSFNQIISLKKLKSFSHALKNLLKLYKENDIIVADHRIHKFL SNKYRDELTKKDCPTE--DTFSDIYSFKKLKSLSKNRKNLIKIFKEYDLIVCDIRIQKFL -SSFKEHFTKAGSPTE--DLFHQIIPFQKIKSIGQSHKNLVRLYKENDIVLADTRIHQRL STPYRTALTEKDSPTE--DVFNQIYTLTKLKSIAKDPKKVYKLFKEFDIVVADNRVHKFL STPYRHALTEKDSATE--DVFNQIYTLTKLKSLAKDPKKLSLMFKEYDLVVSDNRIHKFL STFYKDILTKDEATS---ELFKEIIGLKNLKRRFR-GSKLNQLYKEFDLIVADYRVHHLL TAKYAEIFQADEASTK--DTFADIISVKKFRPKLR--KDPLSVGKDFDLIVADSRIHEEV PAILGSRFYHSSKKTPYMVRINKE----------VKHKGAKMDETIDPVYLKAQLKSICR PSVLGSTFYRSNRKLPFVVRMSKQ----------IKEKGSKMKEDCDPKYVKAQVKSICK PDVLGNRFYHGSKKLPYMIRMSKE----------VKLKRQQMAEKCDPIYVRAQLRSICK PNILGSRFFHGSKKMPYMIRMSKA----------VKVRRQKMEEECDPIYVRAQLRSICK PEVLGSRFYHGSKKLPYMIRMSKE----------VKLKRQQMVEKCDPIYVRAQLRSICK PDVLGNRFYHGSKKLPYMIRMSKE----------VKLKRQQMAEKCDPIYVRAQLRSICK PEVLGNRFYHGSKKLPYMIRMSKE----------VKLKRKQMVEKCDPIYVRAQLRSICK PEVLGSRFFHGSKKLPYMIRMSKE----------VKLKRQQMTEKCDPIYVRAQLRSICK ------------------------------------------------------------ PHILGSAFYRSNKKVPFVVQLSRQ----------PQPSRSGAPDDVDPKYVRAQLRSICR PRILGSAFYHSNKKLPFVLQMSRA----------VKVKGAKMAEGCDPQYIRAQLCSICR PNVLGELFYHKNKKLPFLIQMAKPQGPSILDGLTISKENKIKDERCDPKYINLQIKSIVK PQILGSAFFHSNKKLPFMIQMSRA----------VKVKREKLPEECDAAYVRAQLRSICK PDILGARFYVKNKKIPFMVQMAKP--DKDARLSKGKKSTKLKDDRCEPEYVRYQMKSIVR PNTLGELFYYKNKKIPFLIQMAKPSSSNDIDGLTISKENKIKDNRCDPKYINLQIKSIVG PDLLGSTFYLKKKKIPYMIQMARPPLNGAQQGLRRSKENKLKDDRCDPKYVYAQLRSIVG PDILGEIFYLKNKKVPFIIQMAKP---NKDAELIRSKQNKLKDERCDSKYVNLQINSIVE PSILGSQFYAKNKKVPFKVLMAKP--------EPGRRTHGKINQECDVKFVRSQVKAITG PNILGAQFYLKNKKIPYMVQMARP--DPNAELTRAKKSNKLKDDRCDPKYVKSQMKSIVG PDILGAQFFLKNKKIPFMVQMARPSPESQAQLTKSKSSTKLKDNRCEPKYVYSQMKAIAR PTVLGSRFYNGNKKLPFVIKMSRK----------ELVRHQKTEEECDPIYVRAQIRSICK VECLSKKISLRHLTKPFPIRFIQP---------GKEDDARDANMFADPDYVKAQVRGLLR NTSYMPNEDNCINVKVGFVSTHTAKQILENIQDVIEFLSDKNMKPSGGVIKGSIKSLQVK NTWFLPNKDNCLSIKIGEIGVHAEAELMANAEDVIDFLCDRSKKPQGGCIDGKISSIFVK NTSYIPNDDNCLSVRVGHIQKHSLPEILQNIQDVVNFLTDRSKRPQGGVVKGGIISIFVK NTCYVPNDDNCLNIKIGEISKHSVDEMISNIQDIVTFLSDASKKPQGGVIKGGITSMFVK NTSYIPNNDNCLSVRVGYIQKHSIPEILQNIQDTINFLTDKSKRPQGGVIKGGIISIFVK NTSYIPNDDNCLSVRVGHIQKHLIPEILQNIQDVVNFLTDRSKRPQGGVIKGGIVSIFVK NTSYIPNDDNCLNIRVGHIQKHPIPEILQNIQDTVNFLTDRSKRPQGGVIKGGIISIFVK NTSYIPNDDNCLSVRVGYIQKHSIPEILQNIQDTVNFLTDRSKRPQGGVVRGGIISIFVK ------------------------------------------------------------ NTWYLPTPDNCLTVRIGVVGVHRPEEMLHNIEDVVKFLCDKNQRPQGGAIRGGVKSLFVK NTSYVPNNDNCLSVKVGEVGIHEVEEMASNIQDVVDFLSDKKNKPQGGIIRGGIASIFVK NTNYLPNKGDCISLKIGYIN-WSIDELLININDIIDYLINKEYIGGGGIILNNLGNIHVK NTHYVPNVDNCLSVKIGEVGVHTPQEMVQNIQDIVQFLTDKKKKPQGGVIRGGISGIFVK NASYIPSTGTCISVKIGYSD-WKPEELLTNANDVIKYLVEPKFLPVGGLLPKNLVSVHIK NTNYLPNKGDCISLKIGYTN-WSIDKLLININDIIDYLLNKEYIGGEGLILNNLGNIHVK NTSYLPTLGDVISLKVGYTN-WDIDKLVTNINDVINYLVDEKYRPVGGILLEHLGNIHVR NTNYIASKGDCLSLKIGYCD-WKLDHLLMNLNDVIDYLINEKYLPIGGVLLDNLGNVHVK NASFIPPHGNCINIVVGYSD-WKISELLTNINDVILYLVDEKALPVGGLLVENLHSVLVR NTSYLPNNGNCLSVKVGMHN-WEVKQILKNIDDVIQYLTEDRFRPVGGVLVENLGTIHVK NTYFIPSKGTCVSIVIGHTE-METPAIVTNLNDVIGYLVDSKNLPVGGLLIENIVSVHVK NTSYVLSGDDTIAVKIGVLHKHSISEMVENIQDIVDFLSDKTKKPQGGIIKGGIKKIWVK STSVTLPRMACLTALVGYLPDNTAKEIEENSHRVANNIVDNL-VDGG---ARSTKTIYIK TASSASIPIYQY------------------------------------------------ TSNSLSLPIWKK------------------------------------------------ TSNSTSLPIYRF-------------------------SEA-------------------- TSNSASLPIYEK-------------------------PEAG------------------- TSNSTSLPIYQF-------------------------SEA-------------------- TSNSTSLPIYQF-------------------------TEP-------------------- TSNSTSLPIYQI-------------------------SEA-------------------- TSNSTSLPIYQF-------------------------SEA-------------------- ------------------------------------------------------------ TSNSVSLPIYKA------------------------------------------------ TGNSTSLPVYRA------------------------------------------------ TNQSISLPIIDN-------------------------NGMP------------------- TSNSISLPVFKA------------------------------------------------ TSESISLPIFKQ------------------------------------------------ TNQSISLPIIDT-------------------------TNGMINGKDGH------------ SDNSISLPVMVK-------------------------ADEVL------------------ TSDSISLPVYIK-------------------------HKDGEND---------------- TSNSVALPVMKK-------------------------RE--------------------- TSESISLPVFTP-------------------------AD--------------------- TSESVSMEI--------------------------------------------------- TPNSDSLAIYDS-------------------------TN--------------------- SPKTVGLPIWRL------------------------------------------------ -------------------NENKEKNIPNDRLVL-------------------------- -------------------LEQESIDDDEEIRL--------------------------- -------------------KKIHESEDLSDIRL--------------------------- -------------------PIAHEDEEYESLRL--------------------------- -------------------RENQKNEDLSDIKL--------------------------- -------------------KENHESEDLSDIRL--------------------------- -------------------KENDERENLSDIRL--------------------------- -------------------KENTESENLSDIKL--------------------------- ------------------------------------------------------------ ------------------------SEKPVEFEDQIRL----------------------- -------------------KKKEQPAPETELRL--------------------------- -------------------KGNNDGEEEEDSDFDF------------------------- -------------------EKKTQDPEERELRL--------------------------- -------------------KEDIKEEDDDDSDLDF------------------------- -------------------DDDDDDGNDSDFDF--------------------------- -------------------KDGNGEGDDSDFDF--------------------------- -------------------TNEDDDDNNSDFDF--------------------------- -------------------EKEKEESDMSDLDFD-------------------------- -------------------PEPEDDNDDSDFDF--------------------------- -------------------KKEKGIEEKN------------------------------- ------------------------------------------------------------ -------------------EKEGQTLEEEE------------------------------ -----PPLNPLLNAICNCGEPNSDKYLILVPPTELLLYYSDKESNSELHDLCYTPNFASA -----PVLNPLLNAIFNCPSPKTERFFILVPSTETLLQFQDLESGLELAELCYHYDFVAS -----PTLNPLINAIFNCPEPEKRRFILLAPPSHLLLNYHDVKTKLPLHELCYNADFINS -----PTLNPLLNSIFNCPNPSNKSFILLVPPTETLLNYTDTKTKIQLEDLCYNVDFIGA ---------------------------------------------------------MDS -----PTLNPLINAIFNCPEPEKRRFILLAPPLRFLLNYHDVKTKLPLHELCYNVDFINS -----PTLNPLINAIFNCPEPEKCRFILLAPPSEYLLNYHDVKTKLPLHELCYNAEFINS -----PTLNPLINAIFNCPEPERRKFILLAPPSEYLLNYHDVKTKSPLHDLCYNAEFINS ------------------------------------------------------------ -----PVLNPLVNAVFNCPAPGAKKFILVVPRTEVLLQYQDATTYVPLTELCYNYEFVAS -----PILNPLVNSVFNCPTPSTQRFILVVPNVNILLHYQDLDTGSSLQDLCYTYEFVAN -----PIIIHSLIVFLTIHNTSNTNFTILVPPAHVLNEYYDPTTKTLLKELCYNEDFIRS -----PVLNPLINAVFNCPTPLNVRFVLIAPPTELLLEYEDLESGLPLQDLCYATGFVSD -----PLYNPFLNCIFNNPHHSKNDYTILVPPAHILHELFDPSTKIRLHDLCYNEDFIRS -----PIHNPFLNCIFNNPQYFKTNFTILVPPAHVLNEYYDPTTKTPLKELCYNEDFIRS -----PIYNHLLNCIFNNPHYNKNQYTIIVPSAFVLNEFYDPATRVLLKELCYNEEFIKS -----PIYNPFLNCLFNNPQYFKTHYTILVPPANVLHEYYDPTTKTLLRELCYNEDFIKS -----PLYNPLLNCIFNNPHHSKNDYAILVPPAYILQECYDHSS-QKLSEICFSEDFVKS -----PLYNPFLNCIFNNPYYNKNDFTILVPPAHVLHHCYDPATKVLLRELCYNEEFIRS -----PLYNPLLNCIFNNPNHSRTDFTIIVPPSSLLHNSYDPESKIALHDLAYNEEFIRS -----PVLNPLINAVFNCPDPINKNFMLIVPPNEILLHYRDPEKGLTLKELCYEFEFVAS -----MSMNPLLSFLFNHPNPSQSNYAILVPQIS-LDDHCDAEL---------TPEAVFS HILLLDAKAMDQSWNRVIYGDQIKNRAKILDIESIFNNYMKDNTITIMYIDDVFLNGTLE HIVVIKDTTLNGRKNSTIVGFTERRKITIKEINLLFNDYLKSNYTPILHISMPLCGDLVP HILLTTEETLDGKTNNVIHGFPLRRRLKILDTKILFNDYFKAEYFAILYIDQPLGCEFVP HILLPPKDTLNGDNNNFLVGSPNRQKIKIERIQVLFNDYLQSTYFILVHIDKPLMKDVIR HQLELPD----------------------------------------------------- HILLTTEETLDGKANNIIHGFPIRQRLKILETKVLFNDYFEAADFAILFIDQPLNCEVAP HILLMTEETLDGKTNNVIHGFQVRRRLKILGTKILFNDYFEATDFVIIYIEQPLSCESVP YILLMTEETLDGKTNNVIHGFHIKRRLKILDIKILFNDYFEATDFIILFIDQPLNCEFVP ------------------------------------------------------------ HTLV---QTINGKSSGIITAQPSAKKCRIQRCELLFNDYLLRTAFALLYIDRPLVGEIEL HIII---KTLNGKTNGIVLGFPSKRRCKITNTELFFNDYLKSKYFPLIHIDKPLMSDAVK HIINTASNTLNNKQNRIIYGFRRSLKLKTLSIQYFFCDYFPRSKFMIIYIESTLFGGIPP HIVLLDGKTLSGKTQGIIFAFDTRRRCRIQRAELLFNEYLKDTTFPIIHVDFPLTGRLAR HIIKTNTVTMNGKQNGIVFGFKKSLRLKVLDINYFFCDYFPGSKFMILYIEDSMFGSFDP HIINTASNTLNNKQNRIIYGFRRSLKLKTLSIQYFFCDYFPRSKFMIIYIESTLFGGIPP HIIQTGSKTMDNKQNRMIYGFRRSLKLKILAVSYFFCDYFPGSQFMLVHIESTLFGGQPY HIISTAANTLNNKQNRMIYGFRRSLKLKIASISYFFCDYFPGSKFMVIYIENTLFGGIPP HIIKTSASTMNGKQNGMVFGSKRSMKLRILNVNYFFCDYFPSSKFLLIYIEDSLFGHKPM HIIRTGTNTMSGKQNGMVFGFKRSLKLNVLLFQYFFCDYFPGSKFMILYVEDCLIGSFDP HIVKTGSNTICGKQNGMIFGFRRSLRAKITDIGYFFCDYFPGSKFMLIYIDNSLYGSSDH HIILDTDKSLNNNQNNNIINSTQKKKYKIIDIKILFNEYLSSEKYTIIYTDYPFSNSWLP HVIRI--ASANGRTNDQVMGYKNNVTVNIVDQYVYVCWYLPCFQNFLVY---EISGYLTE NLRSDIDLLRSPSMRSIPTASKATFDSILRVNKHWSSKFEQHFQKFRLLDLPIDVFHNII LDELQVFSKVAGNKYSKQEQKVLYFEQRIQSISDVAERVALTF-HLTKKIGIRTEWRDSI NDYLHCFNSYEETSKTARNAERSSFENILHIHPAWLTQLGQLFSNYRRADPSKKMFEELV NDELECFDTLTLHDNDGDSSERSQFENIINTNDTWNKRFKDWMNEYKDSEPNETLFKQIV ------------------------------------------------------------ NDYLKCFDSYEEVPKNAQSVERSSFDNILHIHSARLAQLGQLFSNYRRDDPSKKMFEDIV NDYLQCFHSYKKIPKSVYSVERSSFENILHIHPTRLTQLGEMFSNYRTDDPSEKIFECIV NDYLQCFHSYEKIPKNAHAMERSSFENILHIHPTQLTQLGQMFSNYRTDDPSKEIFESMV ------------------------------------------------------------ ITPLRVFGPQEQPLQYQRITAPLPLEQFLRLHPQLGNQLDEVFKDAKEIKELVRLFHELV NDELQVFGVRSTNTSSLPLSEVSSFEQLFRLHPQLGDRFSGLFANFKG-DSLVDFFDKFN RKMLPPLPEVRETNKTDKDIDSVTFEKLLRSFPLLSKAVSDKFYQFRVNSHIKLEFQKIL RDEWQCFRVTKNQEHTNGPKNNISLEQLLRINPEYGESLNDIVKAQRISTHLASHFVQTC NVPVSMQSREMDEIKIEPTLHDITFEKLLRSFPLLSNAVSDKFYQFRLTSSIKFEFQSML RKMLPPLPQVRESNETKKDIDSVTFEKLLRSFPLLSKAVSDKFYQFRVNSHIKLEFQKIL KSSLPLAPILNVNDSSTASKESVTFEKLLRNFPLLARAVGDKFHQFYGTEHIKIEFHKIL RKQLPPLPITQESNITKTNSDTITFEKLLRSFPLLSKAVSDKFYQFRGHANIKLEFSKIL VEGPPATPVDEPK-------SAITFEELLRNFPVLSRAMSDKFRRFQRQQEIRNEFTALV HQHLSRIPQDDETSSQRSVSDSITFEKLLRSFPLLSKAVSERFHQFRVTEHIRIEFHSML EPALEASPKAQQAKIKRPDQESITFERLLRNFPLLSKSVSDPFYQFRVTSVIKSEFDNML KIEIESFYISKKESNNIKAATKSSFRHIINIHKEWNNIFDSYIIDFKNKTSLPIYFREIV -KPLPEAPKEIDQNQYDGP----SFEDILLIYPNVGRQLSRLLSTAAN--------TEEL EEMHEEMVSDNLFKNIVDLRNIIYEYVELNLFDDIWKMILRMNKEVEIDLNPFGNISIYQ RQII---SLDKRLNHLEDLDAMIYDYVELKLFTDIQQQLSEIVEDQELEFKALRSISLNQ EQAFDGMKSDSLFKNFSNLYDLIHDYFELNLYEDIWSRLTIHFKGYEVNTENCEYFSVNQ AVAYNELKSNKIFKGFGHLRRLIHEYLEINLYDHLWLQITTLC---ALDGTRIKNISIEE ------------------------------------------------------------ QQSFDGMKSDSLFKNFSNLYDLIHDYFELNLYDDIWSRLVTHFKGYEVDTEKYKYFSVNQ QQAFEGMKSDSLFKKFPNLYDLIHEYFELNLYDDIWSRLTSHFKSYEVGTEEYKYFSINH QQAFDGMKSDSLFKKFSNLYDLIHDYCELNLYDDIWSRLTTHFKGHEVDSEKYKYFSVNQ ------------------------------------------------------------ EKVYCLIKLDKNFRNYLNLLEMVQGYVELNMYEDVWRKLVQLNGKNEPDYYITRSISLNQ YEAFELIRHERRFENHSKLHQTVHNYVELNLYDDIWKQITQLYRDDEIEYNLLKYIAISQ QEAFSIINSEQTYNLIIDLNKLVHEYVELNLYDVLWSQLIFQFEAYDPEYEKLSCLSLNQ KKALDVVRAYPAFQVLPNLPICVHEYIELNLYDDYWAQLTNSLRDSEIEYSLLKHISVSQ DEAFKVVDSEQTYHLILDLNRLVHEYVELNLYDKLWAQLIFQFQNDDLDYDHLACISLNQ QEAFSIINSEQTYNLIIDLNKLVHEYVELNLYDVLWSQLIFQFETYDPEYEKLSCLSLNQ DEAFKIINGEATYNLILNLDKLVHEYVELNLYDVLWSQLIYQYADYDPSYEQLSCLSLNQ EEAFKIINSEQTYNLIIDLNKLVHEYVELNLYDVLWAQLIFQFEEYDPEYEKLSCLSLNQ DEAFSIIDGERTYNLLVDLNSLVHEYVELNIYNKVWSQLLFQYGLYEDDYRDLSCLSLNH DEAYKIIDSEQTYNIILDLNRLVHDYVELNLYDKLWAQLLFQYQSYDPEYNRLSCLALNQ EEAYQIIDGEQTNNLLLDLNKLVHEYVEINLYDKLWAQLIFQFGLADPDYDELSCLSLNQ DKAYQKMKFEEIFLSFNDLYNLIFEYLESSFYNSIWDHI----DRNMIDTEMMDFLSIDQ DLEFERAAIDPLMVRRTQLEKKIDEYVESQLSRKLWNALIALRTNEDGPVESIKYLSLNQ VDSEFLSTEYSKFLERNIKEASKSLQKIESASNYKSKANILILTLRTLTGNLSFFPLAID VPTNFYPKDEKSSLAKSVNDALEYLKSIDLKTTHSGKLEVLSTTMRLLS--REINGISTD LLTDYYSKDFESKLSRRVSVASKHFQKLALSHSYAEKSKILVETLQHLSLSNGFNNLTMD IDDKFYEMFPLD---KNMVRSTNSINKLNGKNSFNEKSENLIATLQILTENEKGANNLID ----------------------------------------------------GLNNMTMD LLADFFSKDFKEKLSRRVNVASKHFQKLTLTHSYAEKSKILVETLQQLSLPNGLNSLTMD LLADFYSKDFREKLQKRVHLASKHFQKLTLTHSYTEKSKILVETLQELSVPGRLNNLAMD LLADFYSKDYRERLNKRVHLASKHFQKLALTHSYAEKSRILVETLQKLSLPDELNNLTMD ------------------------------------------------------------ LSTSIYPEELDKNLSKRVVQATECFSKLTLTNSHHEKARILISTFQKLTTSQATLDPMID VPTPFYPEKQSKSLKKSLEQATDCFKRLAFSSSHSEKTKIIMDTLQTLTPDADIEDVTID LDIPVNKPWLMNELHERISLGVQEFEKLADSSISAAKTQVVYSTFRILTRKNGNIDPVIN VPSFLYPSNPEKDLRKNVKGAVESFRKIAVTNCHSAKAKVIIETLQTLSLLVDDRAVTID LDVPTDKPWHINELHKRIYKAIDEFSKLSDASILSGKTQILKNTVNILTEKTGSDGITVN LDIPVNEPWLMNELHERISLGVQEFEKLTDSSILAAKTQVVYNTFRILTRKSGTVDPVIN LDVPLNKPWQLNELHHRIYQAVQELKKLSTSSTSTAKMQIIYNTINILTHAPMAPDLVID LDLPVDKPWQMNELHERVSLAVQEFEKLADSSISNGKTGVINNTLQILAKFKNNNSLVIS LDIPVDEPWNLNVLYRRVSDAIEQFSQLANSTVQKQKVLLIKNAVNILTGGNSSPDLVVD LDIPIFKPWQINTLQEKVALAIEEFSKLADSSILTAKTKIIINTVNILSDLKSGSDFVMD LDIPVDEPWLLNDLLLRVYNAIIELSKLADATISSSKLKIISNTISILT-ENSNSSLMID LELELYNQNFQKNLVRCVKDATDQFKKIIDSKSHSEKCQILIDALQKLTDDVHYEPLMVD VDLPENEK----HWEAKVVAAANVLQTLANTSTESCNCRFLENTLMKCIDTLTDDSIQVN ADRLMNLFVLVTCRAQIKNLKCHLSYLQNFYNNDSDKFGILGYALSTLEAVVCYFEQNYR ADTLLSLFVLLICRSQVTGLVRTLTYLTNFEISETSKFGLQGYVLSTFEAALSFFHQTVD ADTLISLFVLVVCRSEQKHIRSHLYYLQNFSNNSSSKFGILGYAISTLEAVVCYFENNVA ADTLINLLILIICRSEINDLKRNIFYLKKFNYDENLNFGILSYTISTFEIVIYSFENEYD ADTLISLFVLVVCRSEQKHLKSHLYYLQNFSNNSSSKFGILGYAVSTLEAVVCYFEDNVA ADTLLSLFVLVVCRSEQKHLKSHLYYLQNFSNNPSSKFGILGYAISTLEAVVCYFEDNLA ADTLISLFVLVICRSEQKHLKSHLYYLQNFSNNSSSKFGILGYAVSTLEAVVCYFEDNMA ADTLISLFVLVVCRSDQRHLKSHLYYLQNFSNNSSSKFGILGYAVSTLEAVVCYFEDSMA ------------------------------------------------------------ ADTLLGLMVVVVCRAQVKNLKSHLDYLREFAQNSDDKFGLLGYSLSTLEAVVGYFDIKLE ADTLIGLMVLVVCRSQVKNLKSHLFYLQNFSLDENTKFGVVAYALSTLEAVLCYFEDKIR ADTLIGLLIMVMIHSKIENIEAHIYYIKHFNSIDNTNDGQFNYIMSNLDAVLFHFSKGYL ADTLVSLFVVVVCHAQVKDLRSHLFYLQEFTKDTNLTFGILAYGMSTLEAVLCYFESKVA ADILIGLLIMVIVHARVDNLEAHLYYIKHFNSVDYTNDGYFCYILSNFDAVIYHLSSQYA ADTLIGLLIMVIIHSKIDNIEAHIYYIKHFNSIDNTNDGQFNYIMSNLDAVLFHFSKGYL ADTLMALLIMTIVHAKVDNFEAHLFYIESFSASDVVCDGHFSYIMSTLDAVICHLSDGLN ADTLIGLLIMVVVHSKIDNLEAHIYYIKHFNSTDHSNDGQFNYTMSNLEAVLFHFSQGYV ADTLIGLLIMVVVHSKVPNLEAHLYYIRHFGASSTCESGYLNYILSNIDAVIYHLSSGLK ADVLIGLLIMVIVHSKIDNLEAHLYYIKNFSAIDYSGDGHFNYIMSNLDAVLFHLSSELS ADTLIGLLIMVVVHSKIDFIEAHLYYIKNFMYGTISDDGYLSFIISSFDAVFFHLSHQYA ADTLMNLFLLVICRSKVPFLRNHLYYLQNFSTDENNKFGLLGYGISTFEATLCYLKDKFN ADVLVSLLLVVVARANISHLNSTIYYIRSF-SSNAVDSGKLGYMLSTLEAVMYHIGENRE KLIDFCNSNERLVKVLSSTKKNAALYFLRKYEGSLRYRDSLGQSLLALCIIHGRNDFLYH SLTKKCASNKKIWASIQK---HSKVEAELLSSNL-RIRTDSGESLLSICIQSHNNEVLTT KANLLCIKTRDLLDKLSCENPTNEVNDLATYKDILAYRNEQGQSILSLCITNNKNDILLD KLKSYSEIIEKLIKVDDLKKV----PKTIKWEQFLTFRSDTGESILFSCITNNQTEKFLD KANTLCEKTKNLLDKLSCENPTNEVEDLATYKDILTYRNEQGQSILSICITNHKNYILLD KANVSYQKTRELLDKLSSENPTNEIENLATYEDNLQYRNEQGQSILSICITNTKNCILLD KANVLLQKTKRLVNMLSCENVTNKVENLATYKDILPYRNGQGQSILSICISNNKNHILLD KPNVLCEKTKNLLDKLSCENSTNELEDLETYKDILLYRNEQGQSILSICITNNKNCILLD ------------------------------------------------------------ RLITQCQRNKIFWNLIEQGIP--------EHEEVLISRTPSCESVLSLCIQYGRQDVFYD SLEFNCRRNKQFWDHLSCKAV--SFDSLKSYRDILRIRTAGGESCLSVCIQKGNFSGIEC DLIENSKKNYEIWNAIKNNDLNEYPETELPENHFLKSKNINGESCLMFAIKTKRYEIYDC SLEKYCRANLSHWKSISEGSIDLNADTTVPLDDLLKIRTSDGQSCLAVCLQHRRTEEFEL GLVKSSALNHKFWSLIDSGDTQGLGDSKLPNNHFLNSRTVQGESCLMMAVKADNLDAFNY DLIENSKKNYETWNAIKNNDLNEYPDTELPENHFIKSKNINGESCLMFAVKAKRYDIYDC TLIQSSQQNLELWSAIFELDLSFKNAALLPEQHCLKSRNISGEGALTFALKANNYDVYKL DLIENSKKNYDLWNAIKNQDLKEYPDTELPENHFLKSKNINGESCLSFAIKAKNLEVYNL EMISFSAQNYELWYSISMQKMDNYGNTDLPTNHCIRSKNIHGESFFVFAIKAKSPGIFRM DLIVHSQQNFEFWSAIQQGDVENYVGKEIPSSHYLKSKNINGESCIMFAIKAKNFSIYDM DMKESSQKNFEFWSLIRSHKVDKLYGDKLPHNHFLKARNINGESALMLAIRSKNYDTFLL KQVLNCIRNKELISKISSEA-DHSTFQVKLYKDCFKFRNEMGESILALCIKHKKNETLFE QLEAISEANRWFFERVEKGDLSGLQRDDADWKTVFAATNPAGESALMCAVSSNQQSSLTC ILNYETLFPIEDLLADESIDGSTLLIQAVKHDNQYSASLLLNILKDNCTEIELIAYINRH LLAFESEFPLEDILDDRDFALSTLLIQALQVQNSQAAAILSEIILKSCTESEVRSYLNSP VLSYEALFPIEDILEDETIDGSTLLIESIKVGNLEATKILIRIMLFNCTDEELVTYVNKT LLVYEEIFSMDNILDDANVEGTTLLMQALIYRNFKISMVLINLLLRNCSNKQIMEYINKI ILSYENDFPVEDLLEDETIDGSTLLIESIKAGNLEAAKVLIKIMLFNCTEEELVSYINKT VLTYEDLFPMEDILEDETLDGSTLLIESIKTGNIEAAKILIGIMLLNCSEGELVSYVNKA ILSYDSIFPLEDLLEDETIDGSTLLIESIKSGNLEAAKILIRIMMLNCTEEELISYINRT ILSYENIFPIEDLLDDEAIDGSTLLIESIKAGNLEAAKILIRIMMFNCTEEELISYINKT ------------------------------------------------------------ IIAYQSHFTLEDILQDVNQSNCSLLIQALQAGNKDITEAVIDLLIANCTNTEMYAYINKC LLQFEHELPLEDILDDQTINGSTLLMQTLETGNTRMADVLLEILCQSCTINELREYLNRR LINNPNWIPIDSILFEKNVTNQNLLMCALIEETDKIIDDLVDIILNNATLEEQTMYFNMT IKNREAWFPLEDLLHDETTDGSNLLIHMLESGCDRLAVMLINTLISNCTKDELIAFLNHT IINNYQWFSIDDILFDKNTTNQSLLTVALTQESYNIITQLVEIILSNTTLEEQILYFNSV LINDPNWIPIDSILFEKNVTNQNLLMCALIEETDKIIDDLVDIILENATLDEQIIYFNMT LLDNPNWFTIDDILYEKNVTNQNLLMCALLEETKQIVLDLLETITENATVKEQQAYYNMQ LINNASWISIDDILFEKNVSNQNLLMCALIEESNEIMDDLVDIILDNATPEEQYMYFNQT LLTTAAWISLEDILFDVNTTGQNLLMLALQEEVPEIVEDILDVLFANTSKRELELYLNSR LINHPNWFSIDELLFDKNITNQNLVMVALADECPEIATDLVNVILSSATKEEQVAYFNSV LLSNPNWFSIEDILFDRNTTSQNLLMVSLMEETKIITKILIE-ILGSCTLEEQIAYINST ILLFEDMFPLEDILDDEDIEGTTLLMKALKVENEVGAKLIVDVLQSSCSEDELIKYFNRT LLDFG--YTQEDILADRSVQGSTLLVSALRTENEDIIKLVLDRVRDC---ADLAHYLSVG DINKRTAGHFLTNELEVLKLMGKYINWVQKDNAGQTPLFTIFRSYDQDNYDEMVSQSMEY NLHNRITAHYIMQDISLLESVGRYFNWEHKDINGHTPLFAVFRSYDAVNYDEIVTKVLDQ DKYARSVAHYLTHEMDILKSIGSYINWKQKNSSGQTPLFSIFRSYDQPNYEEMVKVAFNI DKFNRNVGHYLINELEILKIIGKYVNWKQRDLVGRTPLFTIFRGYDQPNYDEVISTVFDI DKYARTVAHYLTHEMDILKSIGNYIDWKRKNSSGQTPLFSIFRSYDQPNYEEMVKTAFDI DKYARTVAHYLTHEMDILKSIGSYVDWKRKNSSGQTPLFSIFRTYDQPNYEEMVKIAFNI DKYSRTVAHYLTHEIDILKSIGNYVDWKRKNSGGQTPLFSIFRSYDQPNYEAMVKIAFNI DKYARTVAHYLTYEMDILKSIGNYVDWKRKNSSGQTPLFSIFRSYDQPNYEEMVKTAFDI ------------------------------------------------------------ DIAGRTVGHYLPQNYEIVDRLGKFVDWKRKDLNMHTPLFTVCRAYDHPSYLELLSKCFQH NRWKRTAAHYLTQDLQMADKIGIFFDWEAKDISGHTPLFAIFRSYDHPDYAQMVTNAFRT DISGRSVGHYLFHNYKLISKIGHLIDWEKKDNNSHTPLFSLCRCYDHPEYVELIRAGFNC NKYQRSCGHYLMHAPQLIDLVGDILNWEQRDCNGHTPLFAIVRAYDRPDYFDMVSAAYRA DNSGRSAGHYFHHSPNLIDQIGFLIDWELKDLNSHTPLFSLCRCYDHPDYATLLEKGFDC DISGRSVGHYLFHNYKLISKIGPLIDWEKKDNNSHTPLFSLCRCYDHPEYVELIEAGFDC DLSGRSIGHYLFHNMSLISKIGHLIDWELRDRNTHTPLFSLCRCYDHPEYIELVQAGFEA DLSGRSVGHYLFHNYKLIAKIGHLIDWELKDNNFHTPLFSLCRCYDHAEYIDIIAAGFDC DNNGRTVGHYLSHDLDAMDRVGHLIDWESKDVSGVTPLFSFCRCYDHSQYELLIKKAFEC DNAGRSVGHYLFHNYKLMGILGDIIDWELKDLNSHTPLFSICRCYDHPNYPTLISEAFAC DYSGRSVGHYLFHDYELINEVGHLVNWELKDHNSYTPLFNICRCYDHYAYYDLIKTAFSA DNNQRIAAHYITNQIDVLKRIGLFFNWKIKDDKGYTPLTTICRTYDQECYEQMIETAFFE DEYGRSVGHYFFHSLYLQQQVGSLINWTARDNQGQTPLSSLCRSYDNPDYHALFKNALKT ANWYGLNGFNYLDHVDKKGNTLLHILKCNLPILLADKHINVNATNRSGQTPLMTSIRYKR VKWYANNNFNFKIHEDPKGNTLLHVMKSGIESLLKLPDVNVNKPDSKGLTPLMIYSRYNR ASWYQRHNFGYSDHTDNKGNSLLHVLKTDVSILLQLTKLNINGENYKGLTPLMVYVKYKR TNWYAENGFQMSDHYDLKDNSILHILRSNIDILFTYSKIDINKRNYKGFTPLMIYVKYHR ATWYRKHNFDYLDHTDNKGNSLLHVLKTNIPILLQLTKLDINEENYKGLTPLMVYVKYKR ASWYQKHNFDYLDHTDSKGNSLLHILKSDVSILLQLSKLDINGRNYKGLTPLMIYVKYKR ATWYRKQNFDYRDHTDNKGNDLLHVLKTDASILLQLTKLDINGENYKGLTPLMVYVKYKR ATWYRKHNFDYLDHTDNKGNSLLHVLKTNVSILLQLTKLDINGENYKGLTPLMVYVKYKR ------------------------------------------------------------ CDFYSTRGFSFADHEDPLGNTLLHIIKDGIQLALSTPGANVNKCNTRGMTPLMVYAKYNR AKWYEIRGFNFSAHKDTKGNTLLHVMKTNIEILLEQENIDVNEVNKKGLTPLMVYVKYNR VKKYGETGVDYDKHVDKSGNTLLHVLLKGIPESKMLSNVNVNQLNQRCLSPLMVYVKYNR AGQSKVRNFRVSNHTDDKGNTLLHVIKSDVSILLADPFIDVNATNAKGLTPLMVYVRYNR IKKYGKESIDFDKHIDKMGNTLLHIILKDLSKTKLLTSINVNQLNYKNLTPLDLYVKYNR VKKYGETGVDYDKHVDKSGNTLLHVLLRGIPESKMLSNVNVNQLNQRCLSPLMVYVKYNR VNDNSSRGIDFEKHIDKNGNTLLHVILKGIPETRILSRIDVNISNYRHLTPLMLYVKYGR VQKYGEDGIDFDRHVDKSGNTLLHVLSKGIPETRILSNINVNQLNSRCLSPLMLYVKYNR V--YNQSSFTFENHIDKNGNTLLHVLSKGIPESQLLSRIDINQVNDKLFFPTAIYVRFSR VQKYGGENINFDKHIDKSGNTLLHIILKNIPESQLLSRISVNQQSSKYMTPLTLYVKYYR V------SFNFKKHTDKYGNSILHILLKGIDQSGLLKAINVNCTNSKCLTPLTVYVKYGR AKWYENRNLNFKDHNDSKENTLLHILKCDIQVLLKYDNININAHNLKYITPLMTYVKYNR CLDATG--VDLRVHTDAKGNTLLHTVSDEKVLSTLLNHVNVNQPNKRGMTALMAHAKYAR TENIRDLLCDPRLRVDITQKNNLTAFDFSKDDEITHLLGEHELLNSPWLAVYAHTLKYTN ITNIETIMKDERLLCDLVQQPLMTSLDFTKNPKVTKTILDATFNREP---VVIHSLRFEE LSNIDAITKDHRLILEKVQNSTFTCFDYAKDRLVLSKIGERGANDSIFGLIYLHSLRYHN LSNVKLILGDDRLLFNRYQRELTTCFDYATDSTISNELGKHALQNNTFGRIYIHSLKRSS LSNIDAITKDRRLILEKVQNSTFTCFDYAKDHSVLSKIGERGVKDSLFGLIYFHSLRYHN ISNIDAITKDSRLILEKVQNSTFTCFDYAKDHSVLSKIGERGARDSLFGLVYLHSLRYHN LNNIEAIIKDQRLVLEKIQKSTFTCFDYAKDHTVLSKVGERGAKDSLFGLIYFHSLRYHN LSNIDAITKDRRLILEKVQKSTFTCFDYAKDHSVLSKIGERGVKDSLFGLIYFHSLRYHN ------------------------------------------------------------ IENIREILNDKRLILSKLQDPQLKAIDYVKNPIILNLIGTAMAKNSLYGCLSVHNIKYEE LDNVKCILRDNRLIMEKHQKSLLNCFDYVKNPVIQAELGFHAAEKTKFGEVVAHTFRFEN LENLKEILHDSRLDFLGEDFKNYNVFDYSTKSENFQNIENAVFNYYLHATENVAALNKYD IGNVRTILQDQRLIIGKHQSGALSCFDYVKNPAVLKELGKYASYLPFEFSINVHSVKREG LENLKELLKDDRLDFKFEDSTNYSVFDFSPTNTVLKEIEKLIYNYCFTDTEKIAALNRFD LENLKEVLKDSRLDFLGEDFKNYNVFDYSTKSEKFQNIENVVFDYYLGATENVVALNKYD LENLESILADNRLDFLAEDPSTYNIFDYYAKENV-EKIEKKLIEFYFEAHYKLVALNKYD LENLKYLLEDSRLDFLAEDFKNYNVFDYSIRTEKFQQMEKMIFEFCLQNDENVVALNKYD LDNLICLLKDSRLFFDWEDSKNYNILDYAANETNQAFKQKVVVEEYFRNNIDLGVLNRYD LENLKDLLQDNRLDFLLEDSKNYNVFDYSTPNETFKKIESLIFGFYIVDCKKLFSLNKYD IENLISLLQDKRLEFMFEDKKNFNIFDYQGDNDRGNSETSFIYSHYFPLKCTTVAFNKFD VSNIQEIIRDERLILGKYQKHTLDCYDFVKNTIIFEDLGVRSVRNSMFNLFSAYSLRVEN LKAIEVLCKDPRIDFAPTDNKGMNVFDIARDRRTADFLDECYMSLQPETDKYCEILRVIA SRWNLSLTVKLTTNFTLKTLRGILRVVIKNNMTVFLPVQELVEDLISFFSELMRIKVLEM RKWKIGIFSEGFKKYSLDLIQYYLRYLKIMYPCSFHPVQLLTNELRLLVPGVLRLQSYHT LNATVNVTSVSTAVINMKTIQGLLRSIVKDNPFTFLPIDNYIDGISHLLTIIGKADVRSL TNATFSLTFPLTVNIKVKAIISLLKVIRKKSQISLLPLDRIIKVLVKLVRKIEMLRNQSL LNATTNITSVSTTVINMKTIQGLLRSILKDNPFTFLPLNTYIDEISHLLTIIGKTDVTSL LNATTNITTASTTVINMKTIQGLLRSILKDNQFTFLPLNSYIDEISHLLTIIGKADVRSL LNAAVNITFASNTVINMKTIQGLLRSILKDNPFTFLPLNIYIDEISQLVTIIGKADVMSL LNATTNVTSVSTTVINMKTIQGLLRSILKDNPFTFLPLNTYIDEISHLLTIVGKTDVVSL ------------------------------------------------------------ NAWYLWITSSLTSSYALKDIQSLLQIYNKKHPMSFLPIDHHLETLKTLIISVINLENSML NRWFLWITLKGTVKHNIRAIQGLLQVYLRRNPMSFLPIDAVLEDLHEILVSVGKLEVHRF GGWLIFFKNGDCNYKSLRNIKQILYLIKLKQPLSTFPSEESFWKNYGFSPMFHKVRINRL DEWVLWITVTGVFKRSLRFIQAFLTLFSDAHPMTFVPVDELLRELRALILILNKMDTKRF TTWALFFIKSNLNAETLDRLRKFTYIFKLDHTHSFFPDNETFWLNFPQVPIFAKFRINRI GGWLIFFKNGDCNYKSLRNIKQILYLTKLRQPLSAFPSEEAFWKNYGFSPMFHKVRINRL PSWYIYYRAEDLRPKSLNSLKHILYLEKLQRPFTTFIDSDIFWRNYATTPMFHKLRVNSL VNWLIFFKNGDCNYKSIHGIRQILYLTKLKHPLSSFPEEDSLWKNFSITPMFSKFRINNL KSWIVNVALHTTKYVTMDCLRQFVQIQKFSNPLGFDISPDEFWVNFPPIPFCSKFRANRV QNWFIFFRDSDSNHKSLEMLKQIIYFIKLDNPCTYLPDKDVVWLNYGLTPYFHKYRINRL TTWIVYFHGNQNIILGLDSIKQSHHSFKLKNPHSLIPDVEKVWLNYPAAPIFAKFRMNRL SNWVLYFTFKDTKSVSLKILFNIIKKYNKLYPLHFIPHKEVLLRLTGINNGIQKLKNRAF D-GELCFVIKTAVRRPYSDFVFLQKWLAHEQPLSWFPALMTPTNPFAIPHRPSREILHAM LPFISFCLSALVHIKVLDLNVFQTEENAIKWV----KMNGSVDKKTNQTSDIEDISMIQN FKKLDMLFSYVNTRGKL--WLGKDEEE-----KVLLDVPTPYLSESERFIKLEEINGIQT LHKLTNCFNVLLFLKKVPQNLFTDEASVLYWMRINTSRRNQKPPSKDNPKTMEEINMIQS LRRLTDCLDTLLFFDIGIDSLITDETKLLGWVNENTKLKHNVNKTHGEKKSLEDINIIQS LHQLTNCFNVLLFLKKIPENLFTDEASILYWMRINTSKRNQKPSGKENPKTMEEINMIQS LHKLTNCFNVLLFLKKVPQNLFTDEASVLYWMRINTSKRNQKPPSKDNPKTMEEINMIQS LHKLSNCFNVLLFLKKVPKSLFTDEASILYWMRINTSKRNQKQPSKENYKTMEEINMIQS LHQLTNCFNVLLFLKKIPENLFTDEASILYWMRINTSKRNQKPSRKDNPKTMEEINMIQS ------------------------------------------------------------ LEALTFSLSIIQQREDYKNVFSYTESELSTWLASMVKQK------PNKRDKIEEIHSIQN LCELTLVLKLICQKEEFKKALYLPASDLVNWIESGRK------RTNVSRQRIEEINSIQS IDDFNLLFEGLTFQESINQFLTEYTKETSIFEKQRIGEQLDFDKQSLGEVTYNQIQEIEY LKRCSVTLSMVSQERLFADAFTDSNLN-----LSSSRGLGSSESFTQNMKMMEEVRSIQS IEHVNMYMISLNFHPILTNNFFVKNRNKLTLEINDITNRQESDKRKFSNLVLAQVNEIDF IDDFNLLFEGLTFQESINRFLTEYSQETLILEKRKISEQLDMNKQSLGEITYSQIQEIEY IHRLNILFQSVACQNIGDSRFLTNDEDELVLEKKKITDLLELKKLKLGEVKLGQVQEIEY IESFNKLFQSLVYSQSIDRFLSEYSKEVSILEKQKISESIELEKQQLGDVTFNQIQEIEF LEHLSTYFSSMNFVSDASKFSRCCQSDTSVLDMKEVSSRQEAERLALGKVQLQNIQEIEY IDTLNLFFTGLLYRNGNCYTGRDRERLTLDFIEASLRQEKKR--ANLGVVKLSQIDEIEF LENLNIFLVCLSMHPNFDT-APHETLGLSSSGSSSLDQMKEVIGKQESSSKVHQLAEIET LNLISNYFGTLIETDDFDTLFKNPES-LTKWI----KAGKRKHKKENYYKRMDDINMIKS HLRLNLFLRTLLLHPTFSNWLLVQDISHTHLARTTKKLENKKEKDLEEYIILPEMDEIEG FLKFNITEIERTKNKLEIAEKLSLFSRLKSLNSNENYVTIVSQLFRSTLKYSAEKLLSAE FLKYNLAEFQKLRNCLIILKKLAIVQQIKHITMRNSFLSLGNQMKGVAKSFENTAWSYSY FLRFNFDEILSFKASLNILRKILIFLSLKSEDAYASLLKMGTKVAADAFTTIIKKMFSSL FLKFNVKELYNVLLNVKTLEKLLNFIHLKSKESRLAFVHLVKSIDQIAQATNRSPIIENN FLRFNFDEISSFKASLNILRKVLIFINLKSEDAYKGLNEMGRKLASSAFKGIITNMFSSL FLRFNFDEISSFKASLNILRKILIFLSLKSEDTYDSLREMGRKIAADAFARIFTNMFSAL FLRFNFDEISSFKASLSILRKILIFISLKSKDVNDNLNEMGKSIAADAFAGNLTNMFNSL FLRFNFDEISSFKASLNILRKVLIFISLKAEDAYDGLNEMGKKLAASAFTGIITNMFSSL ------------------------------------------------------------ FLKFSLTEFNYLREKFTVLKKLIIFEHYKSECSQRILYSQGEIISVVPSKRLRTNEFNGI FLRFNLSELSLIRDKISILQKLSIFSELKANQARCMLFSQSVRLTAISQAFGISKDSESA FLEYSLNNFQKYAYLFARLAKLVCIGDSKQRNVLDTIMYRFNKTTVFDDIFTYP-EVNTL ILKFNLSEISALKTAMLLMKKLAVFEGLKGKDLSEACMTFGAKCKYVTQGKIQSHFLNDF FLRFSLTDLVNFQTTIAKFNKLVAISDIKQRIVTDRMFNCLFSSSVLLREYNFANQYKSY FLEYSLSNFQKYAYLFSRLAKLVCIGDSKQKNVLDTIIYRLNVTTVFDDIFTYP-EVNTL FLDYCLDEMRRAIQIFSKLSKVAIIGEQKQIDVQNVENSLLYRFFFQPFKTLTETLVRSL FLEYSSNDLKKYTTLFNKLAKLVCIGDIKQNNVLDILIIRLDDSTIFSDAYIPP-EVNNF FVAFSREDLVKFQKSIAKLNKLVSIGGVKQGDVRFVIDRFLQSLFFVQQRQLQATEGRTY FLTFAISDLYKYKDALHKFGKLSAIADMKQTDIRTVYLSALKKLGNYTDELKLKVEAECW FLSLSKENLLGTLSTTIKFNKLMTVMNIKMNTIREDSLYSAKMLPSIKTNYHTPDY--GY FVQFNINELGKLNRTLAILKKLCTFLALKINESYKLFRNFGALLISNQMKKIDGKYFQIF FVSHALQQVDLMRKATMNLHQASVKLCNAHCKSWMLMKETVDELGTSPRENIIASSAMDT KALLSKITYLKICAQKLHNHILSITTMISNWWHIYGELLNAHKHYTRAFPELANVTLHRS YEFTRNLEYLEHSVVTLLNNFESLLKTTL-WWKHFGELMELKKEWKKNFNDKAPPSFIDI DELLEHVQFLEECTIQLFNSIQTILDRIPNWWKHYGEFLTLHKNYRKAFSAVKPKSPLGI TLIRDELDFLKACTLILTGNIEDILTQIPNWWKLYGELLELNKHYNKLFNQHSAEVVFGI AALLENVRFLEQCTIQLSSFVQIILEKIPNWWKHYGEFLALHKSYRKAFNMVKPKSPLGI AELLEHVSFLEQCTIQLSTFVQTILDKITKWWKHYGEFLALQKNYRKAFSVVKPKSPLGI AKLLEHVRFLEECTIQLSNLVQLILEKIPNWWKHYGELITLHKNYRKAFSVVKPKSQLGI AELLENVRFLEQCTIQLSDFVQIILDKIPNWWKHYGEFLAVNKNYRKAFSIVKPKSPLGI ------------------------------------------------------------ DPFEQAVDFMCMCLDSLTSKIVEVLSKVSTWWTLYGEITNLQKEYQRNFEKGKPNSFFVM TILTSNIDFLKECTNKLVGKIDQLLGKLTRWWKLYAELLDARNQYNKNFPNSVKPHLFGV GVAREYFYWIQMHGDELLHSIQKLVSDINSWKQMYYSICHINSELKLMENTVSQESFLSV EGIANNIALCELCSSLLCKHIGQVLDDIPKWWHTYGELLSLRREYKKSFPDANRPHLFGI KELLTFTAWLELSTIELTKNIRRIL-KLDDWKELHKNIKELNIELTKYETEADTTDSFAI GVAREYFYWIQTHGDELLNGIQKLVSDINSWKQMYYAICHINLELRQMEHDLQENSFLSV GNFGDYLVWIELAGKELLKNIFKISADIQTWKDLYHAIYTINRDLRSMEGSLPTASGIFL GELRDYIYWIQMFGDEVSKNINKLV-DIKSWKEIYYAICHINSELRQIEPQHQSSDFLSV YAFQSYIQRLESGVRELLASCDKVSQKLDQWKQMYHKIVDINVELRRFEDQIVTHPFNFI GGFHSYVFWLQISLDELLKSVNKILEEIRTWKELYSSIRELNSELHQIEGSLSRRSNFSI RTMFQYFIWVELTLIEIIRNVNKVLGRITDWRQCHDRVLSLAGELRKYEDKRHELGWFGI LILLDQISFLEICTIHMSDNFNDLINDIPEWHSVHFILSNLKKQYKRDFSDFDSRNILST FRINNSSPFVFSCYIESLQNMADATLALAHPLAQISHLRLQQMLLVKLQADAVALSTFRF NPKRIKLEERLSEKIKDITEQLNSVGHDIKQMHELAAEEVSRFIDLKTKTLEYALQSY-- EGKRSKFRNKLSNQLKMSSLNLKKIGGEIKTTHESIAVGINLFIEFKEQYHDHIVKSIVD ETKREQSEQRLSVQIKASSKILKELGSEIFSAHENLAEELSNYMEFRKALDQRTIVAFAI ENQRNKAVKKLKTDIDQLKYSLEILGNEIFRKHEMLAEELNKYMEFKGVFKKAIIRNWRR ETKREQSEQRLAVQIKASSKMLKELGSEIFVAHERLAEELSNYMEFRKALDQRSLVAFAT ETKREQSEQRLAVQIKASSKILKELGSEIFTAHEKLAEELSNYMEFRKALDQRTIVAFAT ETKREQSEQRLAVQIKVSSKSLKELGSEIFVAHEKLAEELSNYMEFRKALNQRNIVAFAA ETKREQSEQRLAVQIKASSKMLKELGSEIFVAHEKLAEELSNYMEFRKALDQRSIIAFAT ------------------------------------------------------------ EDKRQKLESKLQSRLSVCSENLQHLDAELKHCHELLAEEISFFISSKNFYMNFMVKAYVN EGKRSKLEEKLSAQIKSCLERLQTLTYEVKQEHEALAEELSIYLEFKTNLRTGIIQDFTV GTSKKARYKKLVVEKSEIVKNIMKLNLEIKWSHELIAAEISDFLKFRTEFLRFGIKRYIS ETKRTKLEQSYAARINHTSVRLSEISTKINQDNERLAVELNNFINFKNEFLKSAIKEHAD ENKKARYKKLLLMKAEE-IKKIMKLNAELKFDHECIAAEISNFLKFKSNFINLGIKRYVR GTSKKARYKKLVVEKSETVKNIMKLNSEIKWSHELIAAEISDFLKFRTEFLRFGMKRYIV ASSKRSKYKKLVVARADLVKQIMKLNVDIKWLHEIIATELSQFIKFRGRFLEFSTKLFVN GTSKKTKYKKLIVDKSEAVKNIMKLNTEIKWAHEIIASEISNFLKFRTEFLRFGIKRYIN ETKNSRYKKLLYSKSQS-VQELMDLNVRIKLDHEAIAAAISQFLTFRSGLMTFAIKQFTR ESKKARYKKLLMTKSEK-VKQIMKLNVDIKWEHEVVASEISSFLKFRCDFLRFGVKTYVN ENKRTRYKKLVLLHSEE-TKKLGLLSNEIKISHEDIAAEMSHYLMFRSKLIPFAIKQFTR KNKREAAEKRISEEIIENTTLFDKVTAHIWYAHENLAEEFNKFLTFKSRFKDVILNMIIP HD-REKEIRLIKNRIHITENEIRRLSMETKNAQITLASELGGFYQVHEHELTLSIKNIVS --LTISKQEHIDELNSVIDSYREVIRKSDLFGKTIQCLQSYNISKIRCLALGSFAEEFPA QRIRENKQIMVRSFDEQIDEARNAIRGSELLQSLHQSLTPFQVTHVRCLALGNFHQDFPA KNISVLQECIDKSFEEIVQSDRDVLKKSEFLSDLFQSLQPYDIKKVRCVAIGNFREDFPA GDLEAVNDDLIKSFEEVLTAYRTTIKDSQMFKDLCEALDSYDIDRIRCLAIGTFHDDTPA TNISVLQECVAKAFEEIVQTNRDVLKKSAFLSDLLENLQPHNIKKIRCVAIGNFKEDFPA TNIGIFQEYIAASFEQNVQANRDFLKKSEFLSDLLENLQPHNIKKVRCVAIGNFQEDFPA TNISVLQENISRPFEEIVQINREILKESVFLSDLFQNLQPHNIKKIRCVAIGNFKNDFPA TNISVLQECIAKSFEEIVRANRDVLKESVFLSNLFQILQPHNIKKIRCLAIGNFREDFPA ------------------------------------------------------------ RRIKQHKNMLVLDFKQALQRCRTEVQESRMFADLTTHLEPHRLTRIRCLALGKFHEEAPA GKINTLKDTMLKSFEELLQGDRHVIKSSSMFHDLCGALEPYKIDRIRCLAIGGFHETFPA EEIKSLKQRS--------MDYGQIIRTSKLFQDISLSLENIEISTIRCLALGSPSESKNA TNIKRLREQLGKSVEELLSERRSTIQSSEMFQDLKKHLEPHGICKIRCVAIGSFHEEFAA LSLCLLKIRKMERLKLKLSKYESIMAESTLFKETIKILQYRSITHIRCLALGSPSDSNAA EEVKKLKQRN--------MDYRQIIKTSKLFQDISLSLENLQISTIRCLALGSPSESKNA EEMRSLRKRKMEELQLGIAKYREVIHNSNFFNEVKETLVENGYTKIRCLALGSPSESSDA EEVKNLKQRN--------MEYRDTIRQSDLYEDIKKSLDC-EITTIRCLALGSPSESKNA TNLRVLRHRHLDAVQLRLSQREAILANSDFFSRSLAVLEDVGFNHIHCLALGSPTKEFQA SETKRIRNNS--------------------------------FTTIRCLALGSPSNSRNA VATTGLNRNGMEKIVDRINVAEQDIGKAELLSIIVSELEDLDISHIICLALGSPESSSAA SAIATLKDQVVKPFEIQLQECRDVIRESVMFKEVTGKIKEFGIDRVRCLAIGDFQEDFPA RNIKRHKELQ-------------------------------------------------- KYQLALLLELLDNINTIEVSLYDPVFNEVDKLFIKEQWHIVEQEHYKCGETLFYMPHAPL RFQLALLLELLYLLKV-RCSFYDPVFDDEDLAYINGNWSVDESSPFLPSQIMFFLPHAPL TYQFALLLEIIDHINSEIVSLYDPVFTKEETIYLETLWIIEENFSESYGSVLYFLPHAPL KYQLALLLELVDFIKVKPVSIYDPVFSKEDKEYIEGIWTIDERWPTDSEKTLFFLPHAPL TYQFALLLEITDYIKSEVVSLYDPIFTKEEIQYLKSLWLIEEEFSENYESVLYFLPHAPL TFQFALLLEIIDHINNELISLYDPIFTENEMHYLESLWVIQENFSEIYKSVLYFLPHAPL TYQFALLLEIVNYIESEHISIYDPIFTQEEIQYLKSLWVMEEEFSANYESVLYFLPHAPL TYQFALLLEIIDYIKSELISLYDPIFTKEEIQYLKSLWLIEEEFLESYESVLYFLPHAPL ------------------------VFTEEDLKFVSQLWSVDENLSAESSRTLFFLPHAPL RWQLALLLELVDYLGHEQCSLYDPAFTAEELSYVEQLWSVDEQSPWSSDKLLFFLPHAPL RYQLALLLELVDHLAHDLVSIYDPVFSDDDKAYITAIWTIDENSP---DSTLFFLPHAPL RFQLALLIELQQLLDAE-VSLYDPIFNEKDNEILKD-FTIEKEFTSDSSKTLYFLPHASL LYQMALLLELWTFLGADLVSVYDPVFTGADRALIETLWSVDETVL--ASEVLYFLPHAPL LYQLAFLTQVCRDFDVNNVSLYDPVFNELDNQFLTNVFKISEKDTFVGLKTLYFLPHASL RFQLALLIELQHLFDAE-VSLYDPVFNEKDCEILKD-FTIEKEFSSDSSKTLYFLPHASL RYQYAFLLELMDFLNITQISLYDPVFTKLDKQVFAS-YVVEESFEPKDDKVLHYIPHAPL KYQLALLLELQDLFDAK-VSVYDPIFNDKDKELLDG-FTIEEEFTSDSEKTLYFLPHASL LYQLAFLKLLVKKFAT-QVSVYDPVFDENDAHLLESVRIADVSKDDDASATLYYMPHAPR LYQLAYVVEIAKFFDIDRVSMYDPVFTSKDVYLLESMYVVEESTELEPKETLYFIPHAPL RYQLALLKKLVEAFKISKVFLYDPVFTDTDKQVITSLYLLENEQSEKTSRTLYFLPHASL RYQLAFLLECLNWLREEQVSIYDPVFSPENLKYLESLWSIDSDPPADTNTTLFFLPHAPL ------------------------------------------------------------ DLTEEVIKREKPKLILGNEMSQHTDRYTEKQLYDKYPLLSKLVYYSKVSNPKINGDGFVR DLTEKVIAEESPKVWLANHLLQHTDRLTKVQLYDKYPLLCKLVNYINSNTATKIDTDFTS DLTENILSSESPHLWLANNMLSHTDRYTKAQLYEKYPHLGKLVHYLQPNIAPETSMDFVP DLTEIILKEETPRFWLANNVIEHTDRYTLLQLFEKYPHIAKLKHLLESQQPAAKTNDFVS DLTENILSSQRPHLWLANNMISHTDRYTKAKLCENYPNLSKLVHYLQTNAPPEVDVDFIP DLTERILASECPHLWLANNMISHTDRYTKAKLFEKYPHLGKLVHYLQPNLVAETGADFVP NLTESILSSQRPHLWLANNIILHTDRYTKAVLCEKYPHLGKLVHYLEPNIALEADADFIP DLTENILSSQRPHLWLANNMISHTDRYTKAKLCEKYPNLGKLVHYLQPNTALEGDVDFIP DLTESVLDKEQPKYWLANHFIAHTDRYTKVQLFEKYPSISKLINSLSATGPRRDSQDFVP SLTESVVEAEQPRLWLANQLVQHTDRYTKAQLFEKYPLISKLVSYLDSGSKVGTSTDFVP DLSEVIVASEKPKLWLANNVIQHSDRYTRLQLHEKYPLMSKLVNCLSLRQQPPLTEDFVS ELTEEVLNTNQPKYFLANDVIAHTDRLTKKKLADNYPTLSIIVHLLGENKVDDG---FTR DLTERIVASENPRFWLANHISKHTDRYTKLQLHDKYPILSKLLNSLVTSEAPV-RESFVS ELTEQVLNDSKPSFLLANDIISHTDRLTKKKIHDTYRTISLLIKVLENTKIAPKESDFIS ELTEEVLNTHQPKHFLANDVIAHTDRLTKKKLADNYPTLSIIVHLLGENKVDDG---FTR SVMEQILKNEKPTAFLGNDIIAHTDRLTKRKLADLYPSMAILVHYSKTDPVEDGNQNNTQ ELTEHILNINKPKYFLANDVVTHTDRLTKKKLADMYPSLSILVHLLEDNSTVKK---FTT SVTDKFIATIQPRWILGNDVTVTMGTLGKARFLAEYPTLATLVHDEKKTVLSDQSEDSAD ELTNVILNNEKPAYILGNDIVSHTDRYTKQKLYDTYPTISYLVHLTQKSR----VVDFVP ELTEEVLSRYHARYLLANDAIAHTDRLTTRKLYDNYRTLSYLVSLTEQSSVDTQ---FQT DLTETVIVQEHPKLWLANNLIQHTDRYTKSQLFEKYPTLSKLVHILSENESAALNKDFTS ------------------------------------------------------------ QESKKSRHIEPTVIDYSSVPSYFDGLIMITNYKSSEDEQWNHSFSDLSLFEIA------- SRKRKSKKFKETVIEYDVIESYFNDCKIINDFENGANKIWLNSFSDLALHVIA------- KRKRKNRKVKLPELDYDSIATKFKSCKILTDFDRGKEKPWINSFSDLTLHAVE----MGS KRKKRTNKFEEPVINYDSVHTHFKECKILTNFQNGKDKEWLNSFSDLTLHLIE------M KRKRKNRKVTPSDIDYDSIAPKFKSCQILTDFDEGKEKPWINSFSDLTLHAIE----MSS KRKRKNKKVKIPDIDYGSIATKFTSCKILTDFDEGKERPWINSFSDLTLHAIG----MGS KRKRKYKRVKLPEIDYDTIATKFTSCQILTDFDGGKEEPWINSFSDLTLHAIG----MGT KRKRKNRKVKLPEIDYNSIATKFKSCQILTDFDEGKEKPWINSFSDLTLHAIE----MGN RRKRKNRAYQEPKLDYSRINSKFQKCESSQDFQQGRNQPWVNSFSDLALHSID------- KRSRRQRVYREPDIDYGSVKSYFTGCTVLTDFSGGRDKPWLNAFSDLALHRIE---MLQM KKSKKKRRFQEPEINYADVCSYFSECKVLTDFDNGKEQPWVNSFSDLTLHLIE------- VSRK---RFKEPVITYDIDSVYFDKVQISRYLHTNKNDAWGTSFTDLAYHYIS------- KRNR---KFQEPIIDYSSIDTHFSECTVLTDFKDGSDQPWINSFSDLALHLLD------- VTLKKKKVFKEPEIEYDYANCYFKTAELARIENVQ--GVWGSSFSDIAFHHII------- VSRK---RFKEPVIAYDIDSVYFDKVQISRYLHTNKNDAWGTSFSDLAYHHIC------- TNQNKRSSFKEPEIEYDLNSVYFDGVEIKRFKHN-KGDVWGNSFSDIAFHNIH------- VSRRK--KFKEPVIDYNIESVYFDKVQIHRYLHNSKQAPWGTSFTDLAYHYIT------- GFRVAGRVYVEPVLEYDVDSAYFESVVVKRLECSA--EAWKDSFSDLALNIIV------- VTKRKKRAFQEPTLNYDGQEWYFMTATVSRFVES-KNDDWGNSFSDLAYHVLE------- VKKKRRQVFVEPKLDFSADNMYFNSTTIKRLPTEG---PWGNAFTDLALHKLD------- KKKKRSRVYREPVIDYDSIDSYFKTCRLLTTFDNGKNSPWNHSFSDLAFHVIE------- -----------------------------------------------------------M ---MGKTKYQELQP-FYH--------VADARLSEGLTYIKETDTLLWVDIYRGEIHRLDS -MTEVTETVHKNGP-YYF--------DSKIRLSEGISYAAESKALFWIDIYNAYIHRVTD GSDFEQVALGSLKP-YHH--------VAGAIHSEGITFVKETNTLLWVDIFKGEVHKVED TLNSETVDLQTLTP-WYH--------FPDARLSEGISYVKETDTLYWIDIYQAEVHKLED VGDFEEIILHDLKP-YYH--------VPGAIHSEGITFVKETGTLLWVDIFKGEVHKVED GGDFEDIVLNDLKP-YYH--------VPGAIHSEGITFVKETSTLLWVDIFKGQVHKVED GGDFEEIVLHDLRP-YYH--------VPGAIHSEGITFVKETGTLLWVDIFKGQVHKVED VGDFEEVILHDLKP-YYH--------FPGAIHSEGITFVKETNTLLWVDIFKGQVHKVED ------------------------------------------------------------ ITPSPTGTMSTMAPEYFR--------DPNAMLSEGVTYSMETRELYWVDIYHARIHRVLD ---MAQIVELSLEP-YIH--------LPDSRLSEGVTYMAKARNLLWVDIFRGEIHKVTD ----MSLTITKDNI-FPK--------GYRGRLTEGVTYDERNNTLLWVDIIQGEVHRVFL ------------------------------------------------------------ MSEFTVERDDILFP------------DYRGRLTEGVTYNPSNNTLIWVDILQGEVHRASL ----MTLTVTKDNI-FPK--------GYRGRLTEGVTYDERNNTLLWVDIIQAEVHRVFL ----MSTQLSASNI-FPE--------DYRGRLTEGITYDYRNNTLLWVDIILGEVHRISL ------MIATKENI-FPK--------KYRGRLTEGVTYDYRTNSLLWIDIIAGEVHRINA ------------------------------------------------------------ MTIQEIIKLDKLNI-FLP--------NYRGRLTEGVTYNPANDTLIWVDIIVGEVHRVKL --MSTQILLG----------------EYRGALTEGARYDKRNDTLIWVDIIAAEIHRVCL ---MSVADYSQLPI-FYH--------DKTAKLSEGVSVYH--DMLFWVDIFKAEIHTLDN FKTPFFPSHALISPTFLLNRGWCIFIDTRYKLGECPTYDSRDNSLVWTDILGETVQRINY VSA--SGTANHKVFNVSQSTYSSGAAIKYPKTPTPLRESVGCIFPVI---TDGQVDTVLF IDD--IST--HTVWHASVDNYEGLYPFT-----TDLPERIGAIFPID---RADGVEEVYF IEH--PESS-HSSFSVTRANYAKDSSIEYPPNPESLKESVGCIFPLFAESSQDEIEQVLF ITT--KGTSGHDYITLRNDNYNADAAIKNPNTAGKYRESIGVVFP-----DHQDKNLVLF IEQ--PESS-HSFFSISRANYGKNASIEYPPNPDELKESVGCIFPILDGASQNEIKQVLF IEH--PESS-HSFFAVTRTNYGKNSSIEYPPNPDDLKESVGCIFPIWSESFEDEIKQVLF IEH--PGSS-HSSFSITRANYGKNSPIEYPPNPDELKESVGCIFPVFNDASHGEIKQVLF IKH--PESS-HSFFRITRANYGKNSPIEYPPNPDELKESVGCIFPILDETSHNEVKQVLF ------------------------------------------------------------ VDN--PEQS-HSTYDINPATYGAASAY---PGSADTAERVGCVFP-----GLGKGGRLLF IDN--PASS-HDFIAISRENYRGKYPCD-----AAYPERVGVVFPIE---TEEGVDKVLF DNTNINTNT--------------SSSSHETLKWDSSNESIGAIC------LTNDPNKLII ---------------------------------------MGVVFPVD---SSDGVKDAFF LEGKFSESH-------------------ERLKFEDPKESIGAIG------LTNDDNVIVI ----------DNIETDPNSNSSNSSSCHEILKWDSSDESIGAIC------LTNNPNKLII DDLNKHEVL----------------------KWNEQGESIGFVA------LTKDLDTVLV TDGTNHEIL----------------------KWESPTESIGAIG------LTSNPDIILV ------------------------------------------------------------ SSEAADKEH-------------------EVIKWGQLGESIGAIG------LTTKNDVILV KN---PEAS------------------HEVIKFSSPSESIGAIA------LTSNPDILVA IDK--VEG--HRMFKITPETYDG----EYPFTKFNCKESVGVVFPID-------KTSAMF DE---PNQV----------------------TTHKTPCSVGCIG------LTETPGVYIA GSKFGVGRCQFSSGEWEYLTLYSHC-PELASGDRWLDLRSNDGNVSPDGKSLYVGVMCDF GAKYGIARMNYTTLRWQYLVHYSDS-GLQ---KDWTGLRSNDGNVSPDGE-IFIGIMNDF GSKFGIGRLDFSSGEWEYVILYSQC-PALSS-DRAYKLRSNDGNVSPDGKYLYVGLMSDF GSKFGIAKGDLVTKKWEYLMLYSEC-KDLDK-ERAMRLRSNDGNVSPCGNYIYIGLMDDN GSKFGIGKLDFSKSEWEYVILYSEC-PELST-DRAYKLRSNDGNVSPDGKYIYVGLMSDF GSKFGVGRLDFATGEWEYLILYSEC-PDLST-DRAYKLRSNDGNVSPDGKYIYVGLMSDF GSKFGIGRLDFDTSEWEYVILYSEC-PDLST-DRAYKLRSNDGNVSPDGKYIYVGLMSDF GSKFGIGRLDFSTSEWEYVILYSEC-PDLST-DRAYKLRSNDGNVSPDGKYIYVGLMSDF ------------------------------------------------------------ AAKRGIAELDLDSGSWRYLYLYSES-GLN---KAWDRLRSNDGSIAPNGAEIYVGLMADF ASKYGIGITEFSTKSWEYLVLYSSC-EKLSR-KDFSRLRTNDGNVAPNGE-LYVGLMNDF CSKYGLAYGDFSSSTIEYFFKYPHT-TNP---DEKLRLRSNDGIIDPWGN-LWIGVMNDF GSKYGIGRVSLETGQWQYEVLYSSC-KEVQN-RDWSQLRSNDGNVAPNGD-IYVGVMTDF CGKQGIGKGSFKTGQIEYFLKYNHD-ETQ-----KKRLRSNDGIIDPWGH-LWIGVMTDF CSKYGIAYGDFSNFTIEYFFKYPHT-NNI---KEKLRLRSNDGIIDPWGN-LWIGIMNDF CGKSGLAYGKFKANTLEYFFKYPLT-EVE-----QKRLRSNDGIIDPWGN-LWIGLMNDF CSKYGVAYGNFINSTLEYFFKYPHD-ESQ-----QIRLRSNDGIIDPWGN-LWIGVMNDF --------------------------------------------------------MTAF CGKYGVALGDFTTGKIEYFFKYPYD------VTKQQRLRSNDGIVDPWGN-LWIGVMNDF CAKHGVAYANFESGKIEYFLKYPHQ---------SSRLRSNDGIIDPWGH-LWIGVMTDF GSRFGIGKIDLNTGKWKYLVTYDQC-KDLTY-DRFSRLRSNDGNVSPCGKFILMGLMNSF GTKQGVALLDFRPGQQQQFKMVHSF-DSL---NLDADIRANDGTVSPDGR-FWISTMAED HV-PMQ----DIGAIVRVDLVGSAALPLPVHLVIDRVKIPNAIHWN-SAGTKMYWTDSLH HC-TVD-SEDPKGALLKVNLRENI-----CELVIDKLMIPNAINWS-QDGTTVYFTDSLN PF-KLE----AIGCILRVDLLAQE-----VEMVWNSMLIPNAIHWDESDQKSMYVTDSLN DV-ELK----NEGCLMRISLVNKT-----MEVVWKNITIPNAIHWS-LDKKSMYVTDSLS PF-DLE----PIGCLLRVDLLAHK-----IELVWNCLLIPNAIHWDESDQKTMYVTDSLN PF-ELE----PIGCLLRIDLLAQE-----IELVWNCLLIPNAIHWDESDEKTMYVTDSLN PF-ELE----PIGCILRVDLLAQE-----IQLVWNCLLIPNAIHWDESDQKTMYITDSLN PF-ELE----PIGCLLRVDLLARE-----IKIVWNCLLIPNAIHWDESDQKTMYVTDSLN ------------------------------------------------------------ SVGGPDTSNAPEGCVLRIHLEGWR-----CQMVLDGIHIPNAINWS-ADGSQFYLTDSLA HV-GVDTSKPAEGCLLRINIPERK-----VQLVLDQVYIPNSINWN-QDKSIMYLTDSLN PIGAKE-GIQPEGKLYRIGF-SKESNKLTCDVMIENSLISNGLCFN-NQGDEFYWTDSLT HV-DLDRRSEPKGCFLRVSLKDKK-----VDLVLNHVHIPNAINWN-IARDTVYLTDSLG DISEQEGKISPEGKLYRINCHDLT-----IETMVDNCYIPNGLAFS-QDRKHFYWTDSLT SIGENEG-IQPEGKLYRISIDQLI-----CDVMIENSLILNGLCFN-NKGDEFYWTDSLT HVTAKEGEVKPEGKLLRITP-DLK-----VDVMIENTKISNGLAFC-SKGTKLYWTDSLN KIAKNE-GIQPEGGLYRITP-DLK-----FEKMIGDALISNGLGFN-EKGDEFYWTDSLT PEGGVQ----PEGRLYRVDCGDLS-----VKTMVTDTYISNGLAFD-QDGKHLYWTDSLT PV-TFKEGVRPEGKLFRIDHKDLS-----ITTMVDDTLIANGLAFS-EDGKKLFWTDSLT HVGDVV----AEGKLYRINCHSLQ-----IETMIDQCYIPNGMAFS-SDGRKLFWTDSIA EF-QVT----DEGCILLYDIEKNA-----LTMFYDHIKIPNSIHWDGKNNDIVYITDSLN VDQKVA----PRGRLFVYD--GQT-----IEEVSGDVHIPNGMGWEGTVSGPFVFTDSAN FCLWEQD----GDD--SSTKKKLIDV--QRHNPEFESPEPDGSAT-----DLVNNVVYVC FSIYKYPYQDKNLI--VEDKALFIDI--KKFNSQFDSPEPDGSFI-----DPDTHNIITA FTIWKCP----GGD--LLKREELIDV-KNSNNQSFESPEPDGSAIWFSKDGKHSGYLFIA WIIWKCD----AQD--LDKKVKLIDI-KNANNQAFASPEPDGSDV-----DSENNILYTA FTIWKCP----GGD--LLKRDELIDV-KNSNNQSFESPEPDGSAIWFSKDGKHSGFLFIT FTIWKCP----GGD--LLKREELIDV-KNSNNQSFESPEPDGSAIWFSKDGNHSGYLFVT FTIWKCP----GGD--LLKREELIDV-RNSNNQSFESPEPDGSAVWFSKDGKHSGYLFIT FTIWKCP----GGD--LLKRDELIDV-KNSNNQSFESPEPDGSAVWFSKDGKHSGFLFIT ------------------------------------------------------------ FTIWACPVVDGSPQ--LLKRTPFYCT-KNTGNDSHTSPEPDGGFV-----DCFTGHTFVA FTIWSIPYADNAPD--LDAKHKFTEF--KGLNKEFESPEPDGSVV-----DFRDGLLYSA FKIWKYDYDKTTNK--LTNKSVFIDL--KQFYPDVEQPEPDGLVM------TNNGEIYTC YKIWAAPCDSVSGAPDVGRKSALVEF--KPLNPDLSDPEPDGSCV-----DPRNGDIYSA YTIWKYDYDYISNT--LSNKREHISVKEVDAVKQFNSPEPDGLVM------TRSGEIFSA FKIWKFNYDKLTNK--LINKSIFIDL--KQFYPNIEQPEPDGLIM------TNNGEIYTC YTIWKFDYDHETNT--LSNKVPFLET--KKVYTDVESPEPDGMVR------TTNGEVYTA FKIWKFSYDKSTNK--LSNKQPLIDL--KELYPDIESPEPDGFVM------TEDGDIYTC FTLWKFDYDHESAT--LSNRQACLDY--RTLFPDVESPEPDGLAM------TRGGDIYQA FTNWQFDYDYATNT--LSNRRPFIEA--KKFFPDEASPEPDGFTM------TKDGHIYHA GVIVEYDYDVSRNE--LCNKKEVLNVKKSLKYRDFA---PDGMCM------TKTNNIFAA FVIWKYN-----HK--TQEKQLLIDFINNGSNKGFASPEPDGSIV-----DYHTNVIYVS HRL-------------LKDKKPFIEI--ENIEGCSMHPEPDGLTL------SEDGDIWTA VWSTHKVQKYSLEDGTLLHEYVLPQSTPRISSCCF---VGR---DLCITTANLDIEQGSS VWSTSTVQRYDT-KGDLIHKWTFPE-TNRISACTL---AQG---HMFVTTANEIIEDN-- VWSTCKIQMFDLAHGKLLKEFILPKSTPRVSCCCF---VGK---DLFVTTANEKINNAVG VWSTHKVQAFDLETGKLLKEYVLPKETPRISCCCI---YGS---DILVTTANMDLPDGVK VWSTSKVQMFDLTNGKLLKEFILPEQTPRVSCCCF---VGK---DLFVTTANAEINDAVR VWSTCKVQMFDLVHGKLLKEFILPKQTPRVSCCCF---VGK---DLFVTTANAKVSDPAR VWSTCKVQMYELASGKLLKEFILPKQTPRVSCCCF---VGK---DLFVTTANAEINDSVR VWSTSKVQMFDLANGKLLKEFLLPEQTPRVSCCCF---VGK---DLFVTTANAEINDTVR ------------------------------------------------------------ VWSTGKVQELDN-AGRLVAAYTLP--TPRVSSCCAG--PAG---ELLVSTAHAGDFKTG- VWSTHKVQCFDA-LGNLVKELVFPD-AARISCCCIG--ADG---DLFVTTGNLNVENG-- VFSTGTILHVEN-QGKENERIIIA--AKRPTCVTIG--SGIKNNEMFVTTGHLKLDDEKA VYSTHKVQMLDS-TGKLQRELRFPD-TPYVTCCCLG--PHG---DLFVTTASRDVLHG-- TFSTSRVLHFDE-HGKYVEAYKLP--AEKITSVTI---GGKLNDELYITTGHPHLSHPTT VFNSGTILHVDN-QGKEIERINIP--ANRPTCITFGGEKNN---EMFITTGHLQLNDKNV VFSTSTVLHVDK-EGQVIEKIHVP--AERCTCVTIGGQDGD---HLFINTANLKLDDFDA IFSSGTILHVNN-KGEEIERIKIDN-AKRITCITT---GGENNDTFYITTGHLELETNDE VFSTSQVVQVST-DGKMHARFKVP--AARVSCVCV---GGKDDNELFITTGHLKLDDPSA VFSTSTVIHVDA-NAQLVSKIQLP--ASRITCVTS---GGKYNDELFITTAHLQLDDFNA MFNGSRVTHIDS-VGNVVEDIAIP--AKCVTNAHI---GGSNNDQLFVNTAHVDHEEKGF VWSTSKVQAYDLETGNLLQQFKIP--QARASCCCI---YKE---DIIVTTANLNIEHPT- QFGASRVRRYSP-EGILKDEIKFP--AACITCPTF---AGKDYNELIATSFNDDKGEG-- -------ASGDSVGGCIYKLT-DVL--DSSTDVGSAKRQPDISQLP-------------- -------ASPEGLGGSIFKVE-NVSTYMGSSKRNPITAEH-------------------- -------FNFDKAGGCIYRIP-NVL--DGDVPLESTKPQPLY------------------ -------KSGDKVGGSIFRIP-NVI--PKG-KIFSTKPQLKM------------------ -------TNTDKNGGCIYKIP-NVL--DGNVPLESTKRQPLH------------------ -------INSDKNGGCIYRIP-NAL--DRDVPLESTKRQPLY------------------ -------TNSDKNGGCLYRIP-NAL--ESNVPLETTKRQPLY------------------ -------TNADKNGGCIYRIP-NVL--DGNVPLESTKRQPLH------------------ ------------------------------------------------------------ -------AHSDGVGGSIFRVV------IPGRRVAQAASPRLAEASFK------------- --------GGEDKGGCLYRVPSSFV--SGQGTVISSKRQPLV------------------ TIDAT--NLDGDLGGFLFKLKVDKD--LNGQKKNIWGGKV-------------------- -------KNTTGHSGALFRVPADQV--AGSGNIPSSKLNPAF------------------ SIDPN--DKTGDLGGFLFRYHLNKP--HDVHVKHIWGGKL-------------------- IIDNNINNNDDDLGGFLFKLKFDKN--LNGQKKNIWGGKV-------------------- KIDPT--DFFGDLGGFLFKYKSDHN--LKGIKKNFWGGDV-------------------- LIPDANNESDDDLGGFLFKIETKSN--LKGQKKNIWGGKI-------------RKSCNGL DIDAN--DKSGDLGGFLFRLKLNEK--LGGAPKNVWGGSI-------------------- TIDPK--DTNGDLGGFLYRVKLDKP--VNGQIKNIWGGQV-------------------- VPNAN--DKEGDSGGYLFKIQLDRS--YEPQPNYIWGGRV-------------------- -------NQADPIGGALYRIPNGRIHPTGDKPNHDDSKVVPVLN---------------- --------------GKVFRVK-LEG--VKGVPKYVFKSA--------------------- -----------------------------------MPPLFRAVTRGILLPTLGFSAGFLT --------------------------------------MSGKISRYVILPLTGFTLGFGY ----------------------------------MIPLLFRLVNRAIILPTVGFTLGVGA ---------------------------------MSKFSIFRSINRLVILPTTGFTLGYVS -------------------------------MSRTIPFLFKLVNRAVILPTAGFTLGVGA -------------------------------MSKAISSLFKLVNRAIILPTAGFTLGIGA -------------------MKREGRSSVGSNMSRTIPFLFKLINRAVILPTAGFTLGIGA -------------------MKRESRSRVNSNMSRTIPFLFKLVNRAVILPTAGFTLGVGA ------------------------------------------------------------ -------------------------------------MVYRLIHKTFVLPLAGLTAGFLT -------------------------------------MAFRMIGRNVVLPAVGFTTGFAT ---------------------------------------MFRSLVRKTTPLLAFGVGIAA --------------------------------------MVPPLLKHIAAPTAGFGLALAL ---------------------------------------MFRAISRISSPFIALGIGFAA ---------------------------------------MFRSLVRKTTPLLAFGVGIAA ---------------------------------------MFRGTVRKTIPLLAFGIGIAA QFFFFPFLSVTTLYRTLESTSHSHNPPSSTPHKQDDQFPMFKSIFRKTVPLVAFGVGLTA -------------------------------------MSILRTFTRVTSPIFAFGLGFAL ---------------------------------------MFKRIVRTSTPLLALAVGVAA ---------------------------------------MLRFITRTTTPLLAFGLGFAA --------------------------------------MLRTFGRTVVLPTVGFTLGVGS ---------------------------------------MATLARTAKIFGLSLVAGATA FLKAWPDEAGAITQKQQGSDMQLLQRADVLQKITQSTLYKQLLRADDVDHTRQSDKIPHG FVKPWHLDES---ALQTLHRPLQDQRTDVLDKLRATEWVKKLKESSDYMMHRQSEKIPVP FVKAW----PDDAGGLSLNDLKTPQRTDILARVEESEFYKKLVSDDNTEHILFSEKIPSG FMKTWPSEAGSMSLKDKLTGPGDNQRLDIISKIQNDRFYKNFEEDTSVIYRRQSETLPKD FVKAW----PDDAGVLSLNDPQTPQRVDILAQIEKSEVYNKLAQDEKMHHVLFSEKIPSG FVKAW----PDDAGVLSLNDPQTPQRTDILAQVERSEAYKKLVEDDSMHHILFSEKIPSG FVKAW----PDDAGVLSLNDPQMPQNMDILTQVEKSKVYKLLVQDDKMHHILFSEKIPSG FVKAW----PDDAGVLSLNDPQTPQRIDILTQIEKSEVYNKLAQDDKMHHVLFSEKIPSG ------------------------------------------------------------ FGQTWPA--TETPGERTAKRPLSGQRVEVLEELEQLEEFRRLVREHG--GVSHSEIIPAG FARPWRSVDEDG-NIQTLKKPLDSQRVDVLGNLAELPLYKKLASDPNVKQTNQSEKIPLQ FPKDWRKGQFGDKKLLV-------INDSVLEQIRSTDRYKQLVNDPNLKHYNSSHAFPDQ FLRPWPQLHEDALKSVTLKRPVHQQRQDILDQLQRHPIYADLIRRENVEQWSQSEKILHP FPRDWRKGNFTNDRKLTSFNQSVI------EQIQNTSEYQKLQGNESVTMHYSSQTFPSQ FPKDWRKGQFGDKKLLV-------INDSVLEQIRSSERYKQLVNDPNLKHYNSSHAFPDQ FPKEWRK------GQFKTEKKLIHINDQVIQQIESTDEYKKLVSDPEIKHYTSSKAFPEQ FPKDWRKGQFGDKKLLV-------INDSVLQQIESSDIYKELSANTNLRMYNSSHKFPDQ FPADWRRGRWAP-EKLTHFNTDVM------HELEKKELFKQLNNDPDIEKYYSSEAFPSQ FPVGWRKGNLRDKKILH-------INEAVVEQIEQTEDYKNLVADPKNVQYNSSHAFPDQ FPYR---------KSVRDTKLQH-INEDIAQKILSSNQAQELINDPEWEQVISSNTFPHQ FIKAW----PDEAGAITLKDAVVPQRPDILEKISQMKLYNDLLNNPSMNHSVQSEKIPRG MTGYHFGALGRHELTYPVATEKDHFHSKESTFLHNSQFAKELR-EKGFRETRLSEKIPLE HKPYHVGQGILFGKDKLEIDPLIFLNEEKGQLTVFYHLGKNLGNEKSQVHKGVISLLMDE HRDYHVGQGLLYGPTKLEIDPVVFTDNAQNKIHVIYHLGHNLGNEKNAVHKGVLSLLLDE HREYHVGQGLLFGKGKLEIDPLVFHNVNRNEVTVIYHLGTELGNREGNVHKGLLSLLLDE HLPYHVGQGVLFGPGKLEIDPIIFHDEADKSIVVFYHLGEGLGNENGNVHKGILSLLMDE HREYHVGQGLLFGKGKLEIDPLVFHDVNHGELTVIYHLGAELGNRDGNVHKGLLSLLLDE HRKYHVGQGLLFGKGRLEIDPLVFHDLNRGEVTVIYHLGAELGNQDGNVHKGLLSLLLDE HRDYHVGQGLLFGKGKLEIDPLVFHDLDRGELTVIYHLGAELGNRNGNVHKGLLSLLLDE HREYHVGQGLLFGKGKLEIDPLVFHDLNHGELTVIYHLGAELGNRDGNVHKGLLSLLLDE ------------------------------------------------------------ HRNNNVMQGLLFGDAHMEIDPVMFYDKENMQFTAFYHLGHKLADEKESVHKGVLALMMDE HQHYHVGQGLLYGPAHLEIDPLVFQDESKKELIAFYHLGNNLGNEKSKVHKGILALLLDE HHKNYVNTGLLFGPDLMEIDPIVFLDEKNGELTSFYHLGDKLISQDGQIHNGIVSTILDE HRDYHVGQGLLYGQGSLEIDPLVLHDPDSRELVVFYHLGRNLANEKGNVHKGVISLLLDE HHKNSVGSGILFGPNLMEIDPIIFINQDEGELTGFYHLGRLLISQDGQIHNGVVSTILDE HHKNYVNTGLLFGPDLMEIDPIVFLDEKKGELTSFYHLGDKLISQDGQIHNGIVSTILDE HHSNYVNTGLLFGPSLMEIDPMVFINEKTGELTSFYHLGDKLISQDGQIHNGVVSTILDE HHKNYVNTGLLFGPDLMEIDPVVFIDENVGELTSFYHLGDKLISQDGQIHNGVVSTILDE HRKNHVGSGLLFGPDLFEVDPVLFLNQGKGELTAFYHLGGRLISQDGQIHNGVSATILDE HHKNYVGTGLLFGPNLFEIDPIVFLNEEAGEITSFYHLGDKLVSQDGQIHNGVVSTILDE HKKNYVSRGLLMGPNLFEIDPIIYMNPTKGEFVGFYHLGSKLVSQDGRVHNGVVATLLDE HLAYHVGQGELFGPNRLEIDPLIFFDEENSKLVIFYHLGKDLGNEKGNVHKGVLSLLLDE YS-RGFLESFLKKPGYLTVDPLLFYKDDGKNMYAFLHVGDHLNGHTGIVHGGFLGTLLDE ALCYCGFPRLPSKRGVTAKLNLKFNREIPADSTVILTATVRESKGRKCIIDGELQVFSDW ALCFCGFPTLPSKRGVTASLDISFQKDVPVNSTIVLNAQVIETKGRKCIITGTLESPPLI ALCYCGFPLLPSKRGVTARLSLEFLEDIPVDTTIMLKASVKECKGRKCIIEGHLEEFPSP ALCYCGFPTLPNGRGVTAKLSLKFLNDLPVNSTIVLRANVRETKGRKCIIDGTVESMPTL ALCYCGFPLLPSKRGVTARLSLEFFEDIPVDTTIILKANVKEIKGRKCIIEGHLEQFPLH ALCYCGFPLLPSKRGVTARLSVEFLEDIPVDTTITLKASVKEVKGRKCTIEGHLEEFASE ALCYCGFPLLPSKRGVTARLSLEFLEDIPINTTIMLKASIKETKGRKCVIEGHLEEFPSA ALCYCGFPLLPSKRGVTARLSLEFLEDIPVDTTIMLKASVKEIKGRKCIIEGHLEQFPSD ------------------------------------------------------------ ALCFCGFPTLPHKMGVTARLAIDFEREVPVNSTVVLRAAVQEAKGRKCVIRGTLEAVPRG ALCYCGFPSLPHKRGVTAKLDIDFHKDVPKDSTVVLRARVVENKGRKCVIKGTLESVPKI GLCSAGFPLLPSKKGVTASLSIDFKNQAPPQSTVVLHAKVKEAKGRKVVIEGYLETLPLN ALCYCGFPTLPSKAGVTARLDLQFHQDVPTDCTVVLRARVHESKGRKCTITGSLETLPYL GLCSCGFPLLPSKKGVTAKLSIDFKNQIPPGSTVILRARVKEAKGRKVVIHGDLETYPLK GLCSAGFPLLPSKKGVTASLLIDFKNQAPPQSTVVLHAKVKEAKGRKVVIEGYLETLPLN GLCSAGFPLLPSKKGVTASLLIDFKNQAPPRSTVVLHARVKESKGRKVVIEGYLETLPLS GLCSAGFPLLPSKKGVTAKLSIDFKNQAPPQSTVVLHAKVKEHKGRKVVIEGYLETLPVN GLCTCGFAKLPSKKGVTANLSIDFKNQAPPNSTVVLKAHVVEAKGRKVVIEGTLSTFPL- GLCSAGFPLLPSKKGVTASLSIDFKNQAPPGSTVVLRAKVVEHKRRKVVIEGSLETLPFK GLCACGFPRLPSTKGVTAQLALNFENEADPETTVVLRAKIIEARGRKVVSGGTLESFDPE ALCYCGFPKLPSKRGVTAKLHVDFTKDIPVDSTVILRADVTESKGRKCIIDGTLETVPTK FVCLGAFPSLPSQYGVTGTLEINYRQPVRENQYLMVRVETKDIQGRKVIADGSIEKFEGW GEKEPN--VEAECILVEPKWFKYFSRLNMF-MTDYYEPINIFRQCAIRGQ----EHGLDV YNPKPTVYATATCILVEPKWFKYVSWINIF-YTKFYRAPEIFRQNAISRRD---ISDDEN EDEAAKKFATANCVLVEPTWFKYFNWLDMF-DNKYYEPTNIFRQPAIRSEKKKILQSITT VGQEKFIYASAECILVEPKWFKYLKSLKIM-HSTFYEPLSLFRQPAITRVAST-DDGSQS KQEMAKKFAKANCILVEPTWFKYFKWLDMF-DTKYYEPTNIFRQPAIRSDKKRILQSMMT KHDIPKKFAKANCILVEPTWFKYFKWLDMF-DTKYYEPTNIFRQPAIRSDKTKISQSITT KQEAPRKFAKADCILVEPTWFKYFKWLDMF-DTKYYEPSNIFRQPAIRTNKKRILQSMTT KREVAKKFANANCVLVEPTWFKYFKWLDMF-DTKYYEPTNIFRQPAIRSDRKRILQSMTT ------------------------------------------------------------ ETEPPAVYARAECVLVEPKWFKYAIRMGFM-TAGLYIACSCLNERGMGQARPAVPDERER VRSKPTIFADATCILVEPKWFKYASRINTF-MNDYYQPANIFRQPAMTRDISCQSLQLKT KSETPLLIAESKCVLVEPKWFKYFAWLQV--MTDYYEPTFLFRQNAIKRFSPSLISSVES GSESSTTLATATCILVEPKWFKHLQWMRVL-SEKYYTPPNVFRQPAMTGNTPQL-----K EGEQPLKIAESRCILVEPKWFQYFSWLQVF-MNEYYEPTLLFRQNAVKKYSPELVSSMSS KSESPLLIAESKCVLVEPKWFKYFAWLQV--MTDYYEPTFLFRQNAIKRFSPTLISSVES KKESPLLIAESKCVLVEPRWFKYFSWLQI------------------------------- KSEKPLLIAESRCVLVEPKWFKYFRWLQV--MSEYYEPTLLFRQNAIKRFSPSLISSVES DGSTPFEIASARCVLVEPKWFKYFRWFQIGL-MDFYQPTFLFRQNAMRSSSPELNGSSES KGEKPLKIAESRCVLVEPKWFKYFSWFQII-MTDYYEPTLLFRQNALRRYCPSLISSVET GKTQPHVIASGKVVLVEPNWFKYFRWVQPV-MSDYYGPTLLFRNNAIRRFSPELVASMST ESETGTVFAKGNCILVEPKWFKYFTWLDMF-DTIYHQPINLFRNNAIRNE---------- EKKKQNVLAEAELVVIEPKWIKEMTQYFKKKIKRHYDSSNPYAQLSMEGSSTKPKSYVEP ATRRVASWQR-SAKLNSPTLRKVSDFLTKKVKSDYWQVSDMD----LSATAFSSVGNLVM STIVRRNCKIEASKLNSSLLRKVSGIVTKKLKTDCWKLSEDT----RDVTSMSLDRDTIL SSTYKKSWQNNTSKMNSPILRKASDYTTKKLRSDYWKLYGINEAQQSIPSDISIVDNILL IRNYKRSWQTNTKRLGSPTLRKISEYTTKRLQSKYWNVSNENKTTNSIPSGISIDGDNLV LSTYKKTWQNNTSKMNSPILRKASDYTTKKLKSDYWKLYGVDESELSIPSDMSIVDNILL SSTFKRTWQNNTSKMNSPILRKASDYTTRKLKSDYWRLYNIDETELSIPSAISLEDNILL LSTYKKTWQNSTSKMNSPILRKTSDYTTRKLKSDYWRLYGVDESELSIPSDISLLDNILL LSTYKKTWQNNTSKMNSPILRKASDYTTKKLKSDYWKLYGIDETEFSIPSDISLVDDILL ------VVLHDTSRIGSPLLKKVSEYTTRKLKSEYWKVNHDNNST-SLPTDLSVVRDTLL KQRLVNRCFRESRVPDSPGTERRTAYTTKKLRSLYWTLRTDAS---LTAFAVAQERDTIL DGNYKKSWQNDTSKMNSPLLRKASGYTAKKLKSEYWKISENDAISPDLNSSLSVSGNRLL LSLSNSSWLLNPYNVKDAILNQSCCLNRTNVKSNYWKIPDESMNLTMSINKNQGGNPILA VNTHRKSWQNDTSRMKSPILRKASGYSTKQLHSEFWSLPITSEST-NFSTSLSSCDNIVL LDLSSSSWLLDNHNPKDEILNKSCSLNRLNIKSNYWKIPDNDMSLTALLRQGDSNKSLLG LSLSSSSWLLNPYNDKDAILNQSCCLNRTNVKSNYWKIPDESMNLTMSINKNQGGNPILA ------------------------------------------------------------ LALSNSSWLLNNYNPKDAILNQSCSLNRTNIKSNYWKIPDQSMNLTMCINSNHGSNPIMA LISKNSSWLLSPNTSDVELVQKACSLDRLNIKSNYWKIPDGDMNLTLAASDQHAASPLVA LSSNVSSWMFNSANPKDEVLNQSCSLNRMNIKSNYWKIPDTNMNLTMAITDTHTDNPLFS FDLNGSNWLLNAENPRDEVINKTCSLNRLNIKSNYWKIPDATMNLTIAVNNAGTNEPKIA LRLKKKNVLFNTSSANTDILRKCSDYTTKKLYSNYYQFNNNNNNNNTDIASIDQYNNSLS SHTPRATFRHHHHRSKSPRLRPQSHYLPSELQSKYWQIPDESHH--LTSVAVHESSPLIA VTSNKDQDNVKLYTYAEDPNMRQLQTITVPGITTATLLPDHEQLLLTGHRDGIVNLISTS LSTSQTSDNLQLFQLNEINELHSLQTITVPGILATDIMQ-HDRILLSGHSDGYVNLIATS VSTMNGKDNLKLFEISSVKKLKELQTITVPGITCICLLPSHDQLILTGHQDGVVNLISTS ITNMDSTDNLKLFSISKTFDLHKLQSISVPGIISSAIYPSYEQLILTGHQDGYVNLISTS VSTMNEKDNLKLFEISAEKKLKELQTITVPGITCICLLPNHNQLILTGHQDGIVNLIATS VSTMNEKDNLKLFEISNSKKLKELQTITVPGITCICLLPSHNQLILTGHQDGIVNLISTS VSTMNDKDNLKLFEISTKKKLKELQTITVPGITCICLLPSHNQLILTGHQDGIVNLISTS ISTMNEKDNLKLFEISSEKKLKELQTITVPGITCICLLPSHNQLILTGHQDGIVNLISTS VSNMNERDNLKLFNISQDRHLYELQSISVPGITSACLLSGHDQSLLTGHQDGIVNLISTS ISNRHSEENLKLYQYDNVKSLRRIQTITLPGVVA-CALPTHDQLILTGHEDAVVNLIATS VSNGSKKDNLKLYQLETANTLRELQSITVPDITSTALLPGHDQLILTGHQDGVVNLITTS ISSGKSESNLFIYELNLFNNLIHHHTISLPNIHAMKWI-NNTRYLVTGNNKGYAHLVSTP TSSMSTKDNLKMYKVRTAKTLIELQSISVPGVSTSFLLPQHDRLILSGHQDGLVNLISTS ISSANDDSNLFIYELDLAENLTHNNTISLPNVHAMRWVPNNELSLITGNSKGYAHLVSIP ISSGKCESNLFIYELNLFNNLIHHHTISLPNIYAMKWI-NNTRYLVTGNNKGYAHLVSTP ------------------------------------------------------------ ISSAKTDSNLYIYELNLFNNLIHHHTITLPNIHAMKWI-NNTRYLVTGNNKGYAHLVSTP VSSANTDSNLFVYELDSLNHLTHHTTISLPNIHGLAWVPQQSRFLVSGNNKGYAHLISVP VSSANNESNLFIYELDLLGNLTHHNTISLPNINGMKWLPNSNRHLVTGNSKGYAHLVSIP ISSGAKEDNLFLYQLDLDSNLTHSNTITLPNIHSMQWVPNHSDYMITGNNKGYAHLVSLP VDQFNNNSNLSILKIMNEK-LFNLQKVNLPKNLISTF--SDSKYILSGDSNGNINLIKTS VGSGGKENNLFVYETTQDKGLIHHQTISLPAIHGLKWLSDLGNILATSHSNGLAHLVLLP FTKGESRIVKRYNHRKHLVMANEVMNINSARAMPVRSIKPWNGMGFVSLINDSLFVFTLN IENGNAKILRRFNHSKHLKDSMDSVDLNTSRSKPIRHLKTWNKHHFTSVINDSLFVYDNQ IYKGCAKIIKRFNHNKFLKTVSSTTPIISPKTAPILKVSPWNKTGFVSLLNDSLFIYDMD TDRNNAKIIKRFNHSKFLTKADHDISTESHSSNPVKKVLPWSNKGFTSLINNSLFIYDLE TYKGCAKIIKRFNHNKFLKTVSTSIPIITPKTAPILKVSPWNKTGFVSLLNDSLFIYDLD TYKGCAKIIKRFNHNKFLKTVSSSTPIISPKTAPILKVSPWNKTGFVSLLNDSLFIYNLE TYKGCAKIIKRFNHNKFLKTVSSSSPIISPKTAPILKVSPWNRTGFVSLLNDSLFIYDPD TYKGCAKIIKRFNHNKFLKTVSSSTPIITPKTAPILKVSPWNKTGFVSLLNDSLFIYDLD RENGNAKIVRRYNHGKYLSNMPATLDNQSYASLPIRRLKPWAGSGFASIINDSLFIYESN LEEGDARIIRRFNPAKYLRAQYGDEAAQEIDSLRVRQLTPWRSTGFIALVNELIFIYTFD TAEGGAKIVRRFKHGKYLKTTNDNLEMMAKKSYPIRKLLPWSDCGFLSLVNDSLFIYNLS VFNTSAEICKRFNHRKHLK----QNQLENTISTPIKHLNFLNNENLLSIYNDYLFYWDHQ ETHGDAKIIRRFNHAKYLKTQPDTLDMKSKRSSPVKIVRAWDDRGFISVINESLFIYDLN NEEGSAEIVKRFNHRKHLKSINKDPSIASHTSTDITKLNFMDKMDLLSLYDNNLFLWDDS VFNRSAEICKRFNHRKYLK----QNQLENTISTPIRHLNFLNNENLLSIYNDYLFYWDHQ ------------------------------------------------------------ VFNGSAEICKRFNHRKHLKKGSYD---DVSAASPIRHLNFLNNENLMSIYNDFLFYWDEQ SYGGCAEIVKRFNHRKHLRAVGKDPSSHLHSSTCVSKLGFLDD-RLVSIYDDTLFVWNHQ NEDSSAEICKRFNHRKHIKKQ------DINKHSTISKLDFMNNSSLLSIYNNNLFYWDEA NDEESASICKRFNHRKHLKSIDET---VQQNQAGISRMGFTKSGNLLSKYNNSLFLWDES LENGNATILKNYNHKTYLK------SLNKTDCFPIRKILNFNN-NFISIINDSIFIYNLE YSSDPAEILKRFNHKHHVS-------IKDTLSTRIKHLEAWRSSSLATLYSQHLFLWDPS NTKTPQYLNSFPGIQSFAIQTSNPYLLGLTGHFGIALLDLKK-TLYIPDPVIDKEYRKSS QCKDPLYLNSFPGLEHVDVNPVNPFTFSLTGKFGIALLDLRLGGIRVPGPQDSNAESGK- SMKTPIFLQSYPGINSFAINDYDPYLLALVGKFGVSLLDLRT-NLYIPDFLDNSTVPGTG KSTSPQFLQSFPGVESFATNHLTSYIIALCGNFDISLLDLRSPNLYTPKLPNRLQHNRPI CIKTPIFLQSYPGINSFAVNEHDPFLLALVGKFGISLLDLRT-NLYIPDILDNSISAGCG SMKTPIFLQSYPGINSFAVNEYDPFLLALVGQFGISLLDLRT-NLYIPGVLNNNISGTME SIRTPIFLQSYPGINSFSVNENDPFLLALVGQFGISLLDLRT-NLYIPDILNKGSSEEIK SIKTPIFLQSYPGINSFAVNEHDPFLLALVGQFGISLLDLRT-NLYIPDILDNGISVANE RPKSPQYLQSFPGSESFAINDRNPYLMALCGQFGIASSDLRSDNSYIPDGNKNANSSSSL DTREPLYMHHFPGVESFDVNPENELLLALSGKYGISLLDLTKMRQYAPAGHLKAFERAAD QGKTPLYLNSFPGIESFDVNPTNSHMLSLSGSFGISILDLRCGNLYIPG---NSSMPGS- QTRSPISISTVSGIKNFDVPENHANTVAICGLFGVSLFDLRDCQFNIPNYNTAQIHDKTQ QHRIPLYLQSFSGLEGLDCNPQNPNLLSLVGQFGLSLLDLRGGNLYSPDAEMLGNCS--- QVRKPISISSIPGIVNFDPIPHSSNLVGICGQFGVSLFDTRQPKFSVPSSVMKQANKRKL QTRSPISISTVSGIKNFDVLENNSNTVAICGLFGVSLFDLRDCHFNIPNYQTQTEKQQSY ------------------------------------------------------------ QIRSPITITSVAGIKNFDVLQTNSSSVVICGRFGVSLFDLRDSKFNIPDHSEKNQSYKKL SMRRPESIAVVPGIRNFDSHTADWTTLAVCGGFGLSLYDVRSATYSVPYSSKLHLQGAQI QRRTPISISSISGLANFDPLPHNANLVGICGKFGVSLFDLRQPKFTVPPSILEYASKKKL QEKKPLSISNISGLHNFDPTIQNSSTVAICGRFGVSLFDTRQPKFGVPASIVHQANRSKM NRKKPIFLQSFQGLGSVAKHE-NKNLLALSGNFGLSLLDLRSNNQYSPNLRNHESKNSNV RGDTPVLTRKVKRAEAFSLSPQDGQVAAACGKY-TSLLDLRAKSVNLLAG---------- SSSDCTWISSCYLAQALGKEVNIWDVRRTDGKAKILPNKGVIEHLSYHTDTLFSSDDQGN -CYTSKWLDEYTVVNSVGKALKIWDIRYGKVRAHLLGHNGHVNSLDYDMKKIYSTDDQGL ESLDCVWIDNHYVAQGLNDKIQIWDIQSCDSKCELYAKKGYVERIKFDSGLLYSSDDQGF KSLACEWIDEFTIAQCFNDTVKIWDIRNND-ECDILPQRGIVESIVYDKKILYSCDDFNN KSLDCVWISNHHVAQSLNDKIQIWDIQSCDGKCELYAKKGYIESLKFNTGALYSSDDQGF KSLDCVWIDNHHVAQTFNDKIQIWDIQACDDKCELYAKKGYIERLKFNRGTLYSSDDQGF KSLDCVWINNHHVAQGLNDKIQIWDIQSCDGKCELYAKKGYVERLKFNTGLLYSSDDQGF KSLDCVWINNHHVAQSLNDKIQIWDIQSCDGKCELYAKKGYVESLKFNTGALYSSDDQGF RSRDCIWIDEFHVVNCFNDVARIWDI---------------------------------- -SKHCLWLDKSLLVNSVGNILRVWDIRCSTGLCEVLGHKSNITAVRYHSHTLYSCDEDGY -SLNCKWLDEHTLANSVGNTVKVWDIRNTKMKFDIQGHKGCINALNYYSQALYSSDDQGY SANIVKWMNTNILAAGHGDVIRLWDIRKQDSYAELYGHNNYITSMEWNNNDLFTGSKDGN -STACAWLDEYTVANTIDNQVKVWDIRSTGAKCTVNGHKGSIKGLKYHTRRLYSSDDEGY GANVIRWNDDNVFAASHMDVIRLWDIRKQDYFASLDGHQGKIISIEWNKNDLFSGGRDGN RANIVKWINTNILAAGHGDVVRLWDIRKQDSYVELYGHNNYTTSMEWNNNDLFTGSKDGN ------------------------------------------------------------ SAHVVKWLNTNILAAGHGDVVRLWDVRKQESFAELDGHNTNVTSIEWSENDLYTGGKDGN RAGVVRWENEHVMASAHDDVVRLWDIRKNETLGEIKGHERKITTMAWNHGDLFTGASDGN GANQMRWNNENVFAAAHRDVVRLWDIRKQDNFANLSGHTDKISSLEWNDGDLFSGSRDGN GSTVVKWKDEYVFAAAHNDVVRLWDIRQQESYATLDGHQGRIISMEWNNGDLFTGGKDGN NSLDCIWIDNYHIANTIHDTVKIWDIRSTDFSLNIDPKKGYIQSLSFNQKTLFTNDDQNN -TNLCAYMNSNLLATAHSDCVRIWDSRHTAG-HKLEGHTDQIRSLEWSPCELHTSSNDGS IIAWDLTNLDRLEYCGLVHGLDAVKYN--MNLPINYSQCGNVVVNGNNNSACTYRKLARK IMSWDIKDLDQVMCCRPSHGIQSFGLPADCV------QNGNIIQSPDLERIGNKKHLGSH VVCWDLQNLHNMKYGELIHGFNSINLNGIRETLLEVFQCGNIIVSGVDNKKRCLESNETS LISWDLTHSNKVDKLTLAQGWDSIQKDMDSVS-----QCGNFLFNSNN-----VKSNGP- VICWDLQNLQNMKYGELVHGFNSISLDSESELLLQVFQCGNIIVSGMSDKNICLKSNDTK VICWDLQNLQNMKYGELIHGFNSINVDFTNEPTSQVFQCGNIIVSGVDNKKICLRSNEIA AICWDLQNLQNMKYGELVHGFNSISLDDTHESPSQVFQCGNIIVSGTDNRKICLRNNETA VICWDLQNLQNMNYGELVHGFTSISLDGVNERLLQVFQCGNIIVSGVDNKKLCLKNNETK ------------------------------------------------------------ IFSWELSHLTDVRRMTLCRSPQSIKTADDCSTTI---QCGNIVVAPDTE-FSSKRNSSVR TVCWDLNNVEHVEKCTLAQGFQSIGAESSIGTQ----QCGNIVTSPDLSRVSHSKFNNP- IIHWDLSNKDNTKLCGLKEGFNSIEFNGKANKLEDQYQCGTILPASNSSIVAMCSTTTTT TIAWDLQGIDNVSECHLATGFLSITEEKIS----EIKQCGNVVVAPKNLRTVSSIKEGQT IVHWDLTS-PDITNCGLKEGLNSIKFNPVKNSVENQRQCGTVLPASNTNIVDMCSVSLTS IIHWDLSSFDHNNNCGLKEGFDSIEFNPKANQLQDQHQCGTILPASNSSIVAMCSTNTDF ------------------------------------------------------------ IIHWDLSSANSIS-CGLKDGFDSVQFNGKANALENQRQCGTVLPASNSNIVSMCSIKT-- IVHWDLSSDDKLSRCTMKEGVNSVRFDATTNTLMTERQCGTLLPASNNQIVDMCHI---- IVHWDLTS-NQFMNCGLKEGLDSVHFNPHMNRLENERQCGTVLPASNTNIISMCSVTGSD IVHWDLSG-PAVGECGLKEGLSSVYFDPVRNSLQSQRQCGTVLPASNSTIVAMASV---- IISWDLTNFKSMKNCILSQGFNTIVQEFNENLINDVYECGNIIVNGNSGNSNYNSNFIHS LRLWNIGRQLEVYSGDLAAQWDEQKASAQWLPRSQMQQRGNIQKKEKKEKKPALYSSSVI VNQRAGTLFSYCDHELGLHRLFSAPVEISLQLSDTETINYEMVHVDKLHDNSHENSSILH --LADSHFISLQDQELRSYSV----VDMPMVLPPPRNPLRLSVSTETKSEPPATMVYSSS ETTNDGSLITLDFCELGLHQICQVQYNVNKPIDITNTANKPTDTANNEVSDSSVLLCSNE NSSTLNGLITLSLEELGIHEICEVKHPITNDLAQYEITHEKDATEDVSLDSSSTIVGTLD DMANDGSLVTLDFCELGLHQICQVQFNVDTGKIIDG-----NGTGKSGISDSSMLSLSNE DTTNDGSLVTLDFCELGLHQVCQVQCDVDTGEPIEV-----HDTTKNEISDSSTLLSSND DMAVDGSLVTLDYCELGLHQICQVQFNANTGKLMI------NDTSTDAISDTSVLLSPNE DMANDGSLVTLDFCELGLHQICQVQFNANTGKIINT-----IDTSKNDISDSSMLSLSNE ------------------------------------------------------------ QFLGDGTLITLDALELGVHKVQDAKCYIA----PSKNKLRRHSELPIKTLAPSAVSHAVE ESLCDGSLVTLDYQEIGVHKI----YDVETPVPPPRNPLRKTAATKSITDIKNLISVPMD HDDEEIKILSIDSSFLGVHNKVSESINVNKPLTISRKPTTTNTHTHSASIDESIVSVHNV ETLNDGSLLTLDSKEIGLHSI----VEIETPFVPPRNPDRQISDGENLESDATLNEES-- HNEEDVKVLSIDSSFLGLHSKIFDAVKVNKPLTISRMPTTKVVPTTPNMSNDTLAEGPDE DNDEEIKILSIDSSFLGVHNKISESINVNKPLTISRKPTTKPTHNRTTSIDESIVSVHNV ------------------------------------------------------------ EDDADTKIMSIDSSFLGVHNKISESFNVNKPLTISRKPTAISHSPSNSIGDNSVISIHNH GSGTDCKILSIDSAFLGLHSRIYAALGAERDKAPQTEPKPSITSAEKFVSSPETLVSSPK NSKDDMKVLSIDSSFFGVHSKIFDAVNISKDFAQAADAARPKLAPEPIVVDDDDLKITKE DHEDDVKVLSVDSSFFGVHSKIYDAVKVDEDLAEPTKPLSINDTLTSDTEPCKLSISQYE NPLNDGSLLTLKNNELGLHQI----KNIQCSFLQN------INYNDELHSDSTLNDSTEK SFMPTGSMVTVDYGSLGIHSMPSATPYNTEPETPRTLTARMEADMSSASDTSPMTSPSMA SDSTTLHSRDDSYSDNESANTTDND--NELAYMDTFKRPVPKVAAYNNPVLSSSSSTLYF DETTKDSSNSAFEDSEDTLEYEAHSSMFDGKTHSFDIPTIPLSGIRRGSDATFVCEGL-- SDQSLTDNSDDMFSNAGNWDCSSANTIGESRLHNDQEDVVLTKRIYSMNDMYLSGSTVAI HDYVDSGAETNQMSLFSTSIPSDLDIAHETSSSGQVKPIIPITGIYSLN--KLSGSTIQL SDHSMTETSDDMFSNSGNWDCSSANTVSEGRLNDDQEDIVFTKRMYSVNDVHLSGSTIVV SDHSITDNSDDLFSNSGNWDCSSANTMSEVRLLGDLQDINLTKRMYSMNDMRLSGSTIFF SDHSITDIPDDMFSNSGNGDCSSGNTISEGRMNGYQEG---------------------- SDHSTTETSDDMFSNSGNWDCSSANTVSEGRLHEDQEDVVLTKRMYSVNDVHLSGSTIVL ------------------------------------------------------------ SDSSLSSDST---------------LVERAQLEELHHDIFG--SGFMSLDLHAEVDHS-- VDSDTTWRQD---SSCSTWDNSSEDFGTPTKLQQQAENVVTSASIYSLSEFRLSGSTVYI SNDTLVNSPT-RFNICESEDEFTFNSSQQTQLNNSVESLSTKYMSLLLPVKDTSTTTTII --------------HNSHWEDASSDFTTPIKEHFSPEFIYQNPSIYSLKNMELSGSTITV FVEVGDIIRLEPKFSFSNYNDSVFSTTSRGSFGESSSSISTPSDIFNFKTDFDFGLGLVY SNNTLVNSPTSN--ICESEDEFTFNSSQQTQLNDSTESLSTKYLSLLLP-IEDTTTTIST ------------------------------------------------------------ SNDTLVNSPTSVSSTFESDDEFTFNSSNRSQVNNSTETLSTKLVPSFNHDLNLNTNNHLL KAYSSALSPLSTNKFLDMWSDSRSSAQNSPFSNNDSAYTLSKSLAYLDSELDRICSEFGI IEDDLEDYNDTFAPQNGNVSTCSHEESSPLKREASFKFQLLSFNTEMFNDLRMARQASVY VQSEVSGFEDFNFTLTEHFNESALSDFARARINDSNTTLDTKHTSFTLDDFTLLFQDDAL NDTQKVFYRNSNKNSASTLTDQNST----------------SDSLYSINKLALSGSTI-- SAATFQSSYDPVKARPATYETSVSSSFIPPLQIKKRVPSGPRNMLPELDLDFDFGLTA-- ----MVMKLYSKLQH----DT-----SYKVVQLDDTILAAVKNG----EPLQFKSM-D-E ----MSVNLYNKLEP----ET-----GYKLLQLSDDLLDAFQTG-----PVKFKAL-S-D ----MSINLHSASEY----DP-----SYKLIQLTPELLNIIQDP-AQNNQLRFKSL-D-D KKRKMSIELYSAVGL----DD-----SYKLLQLTPDLVKILKEG--SDNVLQFKSL-SGD ----MSINLHSAPEY----DP-----SYKLIQLTPELLDIIQDP-VQNHQLRFKSL-D-K ----MSINLHSTPDY----DP-----SYKLIQLTPELLDIIQDP-AQNNQLRFKSL-D-K ------------------------------------------------------------ ----MSINLHSAPEY----DS-----SYKLIQLTPELLDVIQDP-AQNKQLRFKSL-D-K ---------------------------FRLSHLTPELSEVLKDS---NSKLQFKAAGNDE ----MSVNLYTELEN----VG-----TYKVLQLTEELIRAFQSG-----PVELKAG---G --MSGTINLYSKLTT----ND-----NYKLIQLVPELLKALEDP---AQELRFKAL-D-R ---MSEYSVYQQLNE----DTNATKYTYKLLQLPSKILNQLESK---STNLYIK-----S ---MTTSALYSKLHT----EP-----DYKLLQLNPDVLQALESE----GGLAFKAS---R ---MASKSSYSTYQE----IKSPTDHTYKLLQLTPDLLDYIKSNEHGELLLKSPPILK-- ---MSEYSVYQQLNE----DSHATKYTYKLLQLPSKILNQLESN---TANLYIK-----S ---MNSVSVYQRLKP----DA---NHTYKLIQLPPSLQNKLEQD-TNHSSLKLELK-SNK ---MSEYSVYQQLET----DP---KYTYKLLQLPPAILEKLSQD-----DQPSDLLIK-S -----MFSVYNQIST----PQ---DHVYKLVQLPPSLLELMKSS--SSESLEFKA--PSS ---MKKYSVYQQISP----DE---KYTYKLLQLPSDLLRHISDN-ETDNLLIKSSTSTTS -MGKITYHAFNQLSS----ES---GHTYKLIQLPPDVLSHIEHG---SEPLQLKS--SPG ----MSINLHSKLEL----DG-----SYKLIQLTPDLMETLKDD-SLSSTMRFKSL-D-K ----MKLNFYEEYDK----RH-----IYRLIELPEQIIGELEEEYKKTKELQHYSL-TLR TQSEVVLCSSNATWRLKQKNHSNCVMVMK-----RDTSSNLED----------ESEFCSL DAGNVVLCSEDKTWVIKQRNHSNTVILMN-EFAPT-GGIPEDKINTFGLPRP-GADWAGF DKSEVVLCSHDKTWVLKQRKHSNTVLLMK-EFVPE-EPISFEETQLFGLSKP-YMDILSF DKAEVVLCSRDKTWLVKQKNHSNTVLLMR-GEEAE------------------ANKLVAF DKSEVVLCSHDKTWVLKQRKHSNTVLLMR-EFVPE-QPITFDETLLFGLSKP-YMDVVGF DKSEVVLCSHDKTWVLKQRKHSNTVLLMK-EFVPE-QPITFDETQLFGLSKP-YMDVLGF ------------------------------------------------------------ DKSEVVLCSHDKTWVLKQRKHSNTVLLMK-EFVPE-QPITFDETLLFGLSKP-YMDVVGF DDGDVVLCSRDKTWSLRQKNHSNTVMLMH-EFTPE-QETSLETT--FGLPNP-TSDFAGF DDSEVVLCSADKTWAVRQKNHSNTVILMK-EFAP--VPAAETQVSARGPV---QGEWLGY DTSEVVLCSNDKTWAVKQKNHSNTVMLMK-EFVPQ-EIVASEKLETFGMSAP-TMDYLCF DINSLALCTDSETFKLRQMNHSNTVLLLN-K-------------------EP-DNKLIGF DEDGVVLCSKTQTWELKQKNHSNTVMVLK-EFMPDEVPV-ISNRSSFGIAEP-STFHLGF --NHIVLVTDNKTWKMRQMNHSNSVLLLN-NMKINKLNKTLEHIIPVE--EP-TNQLLGI DINSLALCTDSETFKLRQMNHSNTVLLLN-K-------------------EP-DSKLIGF GHDNVVICTENETFKLRQNNHSNTILLMRNEDTNNKIVKNAEATNVTSVQPPQQNWLVGF DINSLVLCTDSQTFKLRQMNHSNTVLVMN-----------KDQ----------NDRLVGF AKNHLVICSDSETYTVRQMNHSNTVLLLN-DMAPNPLEKRLDHLVPSEAA---DRILLGV NPGQLVVCTDDKTWKLRQMNHSNTVLLLD------------NQNIVQHRN---DNNLIGF ESTDLTLCTNNKSWRIRQMNHSNTVFLLN-DLNINCMGQKIQHDSNKEN-EPNSNMLMGF AKADVVLCSEDKTWIIREKSHSNTVMLMH-EFASEGNPV--NNIVINGVPDP-TSDFLGF GKDRLVLCNKNTTWNVKQRSQSNTLHLVE----------TRDD----------GLASICI NDTTYEYELTKVPGSLNYHLIPL--YDGEELSFKT------------TFKELLANSQCSN STLDSELEPRLVDGSIDVTQLDI--YHGKDV----------PLTRKLTLQEFKDMCPCSE AKTESEFETREAEGQLNLAAVPM--YDG-ELDFRERAMKKSSTRIFETLEELLENSPCSA ARTTFEYETRASHGELNLESIPI--YDGDEVFPRDR-----SKIKIKNMDELLENSACSE AKTESEFETRETHGELNLNSVPI--YNG-ELDFSDKIMKRSSTKVIGTLEELLENSPCSA AKTESEFETRETEGHLNLDSLPI--YNG-ELDFRERTTKKSSAKVIATVEELLENSPCSA ------------------------------------------------------------ AKTESEFETREAQGELNLNAVPI--YNG-ELEFSDKIAKRSSTKVITTLEELLEDSPCSA SRTTFEYETKKVSGIINLDSVPV--HNG-SLDFPPADG---QDLPVKSMDDLLASSACSE TQQTCELEPRATAGQVDLSALPI--YNGQHVGDGP------------DVETLVENATCSR AKQTFELEPRPAKGQVDVGRLPI--YHGDEKHFQE------EVMPKMTLQELFESSPCSK QKTSYEYELTEIKGSIDTSDIPI--FNGQTA------------QQPIDLIALEDNSICSH TRQHFELEPRSISGEINYGGLSI--YSGENKVVPENDNDGG--LVKMTLEELRNCSPCSD ANLAYEYELSKIPGYIEIGNLPT--YDG-NFEVANE-----IDSSR-NVEALMNDSPISR QKTSYEYELTEIKGSIDTSNIPI--FNGRTV------------PQRIDLQALKDNSICSY AKCPYIYELAPVKGNINILEIPI--LHPSMLNDLKKLSKSTNFAQSPNKQQLLKSSCCSK SKSTYEYELSPMEGIIDTSNIPI--YDGRTISP--------HSSHNIRLTELENDSLCSH GSSSYEYELTPTEGYIDTSDVPM--YDGTAV-----------PKSAKTVETVLADSPIAR ASCSYEYELTDSKGSIDITKLPR--LHGDELRDSTNN----VHAVQISVDELLENSPISR ASNSFEYELTSTPGSINADRLPI--YDGNEFK-----------PTGYSEKDLLLDSPVSK SKTTFEYETRPANGQLNLDLVPI--YNG-EMNFTVD-----STKLFTTKQELLDNSPCSI TQPILECTLSESP-QLDTSDLPC--YDGDSIMGD-------PRIAKHDLDSLRNRSSMSG EEAMCEWHDIGGCILEGNICKLSDKFITRALDITLVSIMADSLDMSHLDLDEVLKSVRKD KEFVSKWFEVGGSVVQGFACLLSERFMLKALHIILISCMAENLDVDSLSIDKVADVLAKD VEGVSKWRKIGGSVKDGVLCILSQNFLSKALHVLLMSVMAESLDLQRLQIDDTYQAVGKD LECETQWHTLGGCEVNGCLCLLSSGFLSKALHVTLMSVMAENLNSDSLALAETSQAVSKD LEGISKWHKIGGSVKDGVLCILSQDFLFKALHVLLMSAMAESLDLQHLNVEDTHHAVGKD LEGISKWHKIGGSVKDGLLCILSQDFLSKALHVVLMSVMAESLDMQHLQVDDTYHAVGKD ------------------------------------------------------------ LEGISKWRKIGGSVKDGVLCILSQDFLFKALHVMLMSVMAESLDLQHLHVQDTYHAVGKD KECLSQWNQLGGCTVKGYPCILSSDFLSKALHVTLMSAMAESLDFSRLKSDETFDAVNKD AEFYAAWRAAGGCSVGGTACVISPDLLGRTLHLVLATAVADGFDLACVGPEQMWASIARS NEFDRIWFSLGGCTVNGFVCILASEFISKSLHITLMSILAENLDVNNLQLEETHQAVCKD QEFLSNWYELGGCEIDG-AYIMSADIITELLYLLITKL--MSLQVHEFSPEDVSSIITP- REFAEKWPALGGCEVNGRACILSQEFISRALHITLMSCMAESLDFDALDCSQAFAAVNKD EEFYKEWYTLCGCEIEGKAVILSKEFITDGLQLLIPILITKDIDYKSDAFNINISDISKE QEFLSNWYELGGCEIDG-AYIMSADILTELLYLLITKLMS--LQVHEFSWEDVSSIIAP- TEFQHLLIEHLICEIHGHCFRVSRSLEVEILFHIITFLISNQL--SEFNLQDLKEVVKLN KEFFKNWCESGGCEIDGFAYVMSVNVITDLLFLVITKLMSLGKD-GSFTIDEIASVVNNN EKFRHQWHRILGCEIEGVAVLLSPQFVTDALYTLISVLVARQTAFDVSDVAPRVQEENPK QEFFHEWYELGGCEIDGRAYILSPEYITEVLYTLITALISESFNYDTVAVDTIHQLSKKQ NQFYKIWYDLCGCEVHGSAVILSRKFVTDFLSVLIPVIISIDGAYSSEDYNLEVKQISEL KEYRKNWAKVGGSVINGQICILSAEFLAKSLHVTLMSIMAESLDLDILSLDKVFDAVEKG VQFDQVWAQIGGVEVDGVACVLADSLIKETIDDILTSLASQKQQLNLVSASDVVSDTSPA S-ETVKDNPFTKPVIETILNKFGTQEKDH----KWHIDKKRITYWYGLETLKKFAMGIPL VKQ-GEPNLYTHEIVTTVINKFGFKVESA-ETDRFRINMSLIARWYGVSALKKFAAKEPI IED--EFNPYTREIIRTVLNKFAVQEQQS-QEETWRLRIPFIAQWYGIQALRKYVSGTSM MDG--SFNPYTREVVKTVLNRFGTLQEG-----SWRLNHAEIAQWYGIQALKKYVSQRSM IED--EFNPYTREIIETVLNKFAVQEQEA-ENNTWRLRIPFIAQWYGIQALRKYVSGISM IED--EFNPYTREIIGTVLNRFAFQEQEP-ENSAWRLRIPFIAQWYGIQALRKCVSGTSM ------------------------------------------------------------ IED--EFNPYTREIIETVLNKFAVQEQEA-EGNTWRLRIPFIAQWYGIQALRKYVSGISM MDQ--DSNPYTREVIKTTLEKYGKRVKDD-DD-CWQLDQKKVAEWYGIRALRKYASQSSI MGAHGATHPYSREVIETVLHRFGRVGSDG-V--SFELDLSRIARWYGVQALKKFASTEAI MDDDEDFNPYSLEVIRTVLEKFCNKKDGG----TYKLEMKQVARWYGVVALKKFASKELI --------PYNDSMLTSIIHKFCTIESE-----KYQLNDLKITQWFGIVEMSKI-NHKMT MGDAGEFNPFSEEVVSTILNKFCSKLENG----TFKLRRDIVSQWYGIEALKKFASRAMV MRQ--QNRLYTQEVTITILHKFCIKHHESS---MFKLNNLAVAKWFGIQTLFST-NANLI --------PYNDSMLTSIIHKFCTLENE-----KYHLNDLKITQWFGIVEMSKI-NHKMT L-------NWSSSMVYTVIKKYSYSAESTNEA-DFELDDAKIVKLFGIVELGK--TSTTI ---------YNTSMLTSIIHRFASTTSNN-SN-QWVLNDGKITKWFGIHELSKT-NNRLI I---------TSAVVNTLAERFFRRSNS-----VYELDETEIATWFGIETLKK--TSSPV L-------NFADSIVTTIVQKFTVRSDKPNVL----LDNDKIAKWFGIHVLSER-ATLLL LAK--ENELYTPEICWSIFHKFGDVH----EG-KFKLKNIVITRWFGIQALSR--QTQPM FDE--DFNPYTKEVIKTVIRKFGISNESN-DNDTYKLNMLPIAKWYGIRALKKYVSKTSM V-------------VTAVLKMFATTPIEP-----YNLDLAHIISWIGKNAL-----GEPV NQEEFLIKWKSQMPPYFPSDLDIRELRGHYYLDRHTDE-IHYIDKKSLPGDIKQRLVYLF SEDEFMIQWKGQFPPYFHCDLDICMLRGYFVRPLTNK--IRYMSRTTLSLDAKERFKQLF PLDEFLIKWKSLFPPFFPCDIDVEMLRGYHFKPTDKT--IQYVARSTLPTDPKERFRVLF ALDEFLIRWKALFPPFFPCELDIDMLRGWHLKRGDGEAVVQYVSRATLPPGARDRFAALF PIDEFLIKWKSLFPPFFPCDIDIDMLRGYHFKPTDKT--VQYIAKSTLPMDPKERFKVLF PINEFLIKWKSLFPPFFPCDIDIDMLRGYHFKPTNKT--IQYIAKSTLPMDPKERFKVLF ------------------------------------------------------------ PIDEFLIKWKSLFPPFFPCDIDIDMLRGYHFKPTDKT--VQYIARSTLPMDPKERFKVLF PPAEFLIKWKSTFPPYAPFDIEIEMLRGWFFRPTGSN--LQYLSKNTLPSDIKERFKMLF MVDEFMIKWRSLFPAYFRCDLDLELLYGEFARPQHER--IQYLSRSTLPMDIKDRFQQLF SQDEFMIKWKSLFPPYFSCDIDLKLLKGQFARPLRGK--LQYLPPSTLPHDIKDRFKMLF DISEFLLNWKTSLPSFYNPPLDISQLAGYYCSPIENK--ILYVDPESLSENLSQRFKELF PQEEFMIKWKSLFPPYFNCDLEFSALRGHYFRPLGSG--IQYFSKDTLPDDPKDRFSYLF SPKDFLLKWKSSFPPFYNVPIDLSQMRGYYCRPLNEQ--IQFLNPSTLTPDMSIRVKELF DISEFLLNWKTSLPSFYNPPLDLSQLTGYYCSPIEHK--ILYVDPESLSENLSQRFKELF LTQEFLLNWKTSLPSFYNVPLEITYLLGYYVTIQQGH--IQYINPDNLSSDLGTRFKELL SQNEFLLNWKTSLPSFYNPPLDIVQLQGHYCSPMENK--ILYIDPNSLSENLAQRFKELF SDNELLLEWKSSLPPFFTAPLDLALLRGFYCRPVTGK--VRYLARNSLSPEIHARIKEMF SSKEFLIQWKSSLPAFYNVSLDLHYLRGYYCMPVEDN--LIYINRDHLSTTLSARFVELF DCKQFLLLWKGSLPHFYNVPLDLEQLKGYYFKPTSTS--VQYLEPSSLSHNAGSRIKELF SQDEFLTNWKSLFPPFFPCDIDINMLRGWFYKPTGSN--IQYISKETMPMDIKDRFKMLF QIEQFMIMWKNSIPMIFDDMVSLDLIKGSYALCETM---IHKLSESDLPRDPKERFARLF KLQSQWNPDEMAPLMQDLNQKNTKFESFIIKYARIKRLSSKQKVVIQR----GQEELTVS HWQSTWEQADMVPYISDLNTKNLKIDTFIIKYARRKRVGN-KVIISAR----MVVELVIN RLQSQWNLEDIKPLIEELNTRGMKIDSFIMKYARRKRLGK-KTVVTSR----DNNECTFT QLQSEWLLEDIAPFVSELNHRGLKLESFITKYARRRRAGNGRVIVSGR----GDDKLTVK RLQSQWDLEDIKPLIEELNSRGMKIDSFIMKYARRKRLGK-KTVVTSR----VDNRRTFT KLQSQWDLEDIKPLIEELNTRGVKIDSFIMKYARRRRLGK-KTVVTSR----VDNKRTFT ----------------------------------------------------VDNKRTFT RLQSQWNLEDIKPLIEELNSRGMKIDSFIMKYARRKRLGK-KTVVTSR----VNNKRTFT KLQSQWDMDDIAPFVEELNTKXLKIDVF-------------------------------- RIQNAWDIREITPFIEELNTRGIGMDNFVLKYARRKKTGK-TIVVMPR----PGGQLTVE RIQNTWDIEDIKPFIEDLNTRGLKIDNFVMKYARRRRIGK-QVLVSSR----MGNSFTAK ELDKSWNYDEFIPFIKKFVPAGKKVDSIILKYGKKKKVGRDRFIVCPR------------ KLQSTWELEELAPFVEQLNTKGIKIENFVMKYARRKRQGK-RVLVSAR----MDKELTLR QIVKEWEYEEFLPFIEEFIPKGKKPESIVLKYAKKKRVGKNRFMICPR----------MA ELDKSWNYDEFIPFISKFVPAGKKVDSIILKYGKKKKVGKNRFVVCPR------------ NIVKIWPYEEFVSFIEPLVPKERKLDSVIIKYGRKKRLGRDKFVVCGR------------ ELDKKWNYDEFIPFISKFVPSGKKVDSVILKYGKKKKIGKDKFIVCPR--------MTPP QMVREWDYDEFLPFVAEFIPPSKKADSVLLKYTRKRRVGK-KVLVGPR-----MGMVDLF QLDREWNYDDFVPFIKDLVPPGVKVDLMILKFGKKKKIGKDRFVVTPR------------ SVSKEWDLDDFIPFIQEFIPTGKKPDSIILKYAKKKRMGKNRFVVCPR----MWTNQAPQ KLQSQWELEDIRPFIEELNVKGLKIDNFIMKYARRKKIGNSKIIVTSR----VAGELAFT QIKDKWELDEITPFIEPIKMNKSTKENFVLKYAKKRKIGG-KVMVCRE------AQFQIF FSEQLLDPNLSFPDYQQTTRQLTLNRARCVDPTLIDTFLRNLRHGSDDVIKQKLNNYSKQ TNLPELEDVSKEKTFDPN-EKLVLNRERCVNPVLIDNFFRFLRHGSDDVLKQKLNNNKSE APKSLLDSNLTFPNDEPTLTTITVTRERCVDPSLLDSFLRILRHGSDDIIRQKLNNYRKP LPQIILDSNLRFADDKESLSQLTINRQRCVNPTLVDSFLRLLRHGSDDVLKQRLNMYSRD APQSLLETNLTFPNDEPSLTTITVTRERCVDPSLIDSFLRFLRHGSDDIIRQKLNNYRKG APQSLLESNLTFPNDEPSLTTITVTRERCVDPSLIDSFLRFLRHGSDDIIRQKLNNYRKA APPILLESNLTFSNDGPPLPTVTVTRERCINPSLIDSFLRFLRHGSDDIIRQKLNNYRKS APQSLLESNLTFPNDEPSLTTVTVTRERCIDPSLIDSFLRFLRHGSDDIIRQKLNNYRKG ---------------------------------------------------DRXNGARRF VPAPRADTGSGPSAHGAANRRITINRDGCVNPSLIESFLRELRRTTDNVVNQRTNDLQNA APSSVLNAGSEFLPNASEMMDLTVTRERCLSPSLIDSFFRVLRHGSDDVIKQKLNNTKTN MPTNQ--------PTKFEVPVDLLTPESCISSSRIRAFLKRSRNLTDDTIRPHLNEIEK- APARVLDTNLVTKGDVAKTEQLTMTRERCLNRELIDSFFGILRHNSDDVIRQKLNNMNNL YKESV-------------TPKSLLTPENCHSSSRIRAFLRLSRIATDDTIRQHLNEVKSS MATNQ--------LSKFRAPTDLLTPESCISSSRIRAFLKRSRNLTDDTIRPHLNEIEK- ------------------------------------------------------------ RPQN---------KSELEVPSNLLTPEGCISSSRIRAFLRLSRHVTDDSIRPHLNELKK- YNNNNTS------ETEPTAPSTLLKPESCESSSRIRAFLRLSRIATDDTIRQHLNEIPR- MTASLLSQLL--------VPPSLLTPQNCHESSRISAFLRLSRLASDDTIRQHLNEVKTP TDSPMVS------QNTGPAPPQLFTLENCTSSSRIRAFLRLSRIATDDTIRQHLNEIKP- AEWSPVDSNLDRDSNDIRVERITVNRSRCINPTLVNSFLSMLRHKSDDIIKQRLYAYATF HSNLHNPDLSPHTMSSWTPPKPGLTAANCIEARALRQFLRASRKTVDDRVLVTISKLGND TEHRNQKCDSLIHREIYPNWQVRDSIIDFCAAQATQLKYELDQQKSSEVI---RTTVDTR GSKD-LNCNILLNQMLYPNWKVRSDVISFCESELKSMKTEVNDKFGSESDP--KPLVTER SSNSENKCERFLKQELYPNWQIRSSIISFCDQEATQMKAETDQKFSSTGSSAIGPITDAR EEM--NKC-EVVKEELYENWNIRLDIINFCEEQSRQIKETLDLKYGSNASLS-EHKIDPR SINGKNKCKEFLKQELYPNWQIRNNIISFCEKEAAEMKNETDQQCGNNKKTTAEPLIDAR SSNGKNKCKEFLKQELYPNWQIRNNIISFCENEAANIKTETDQKFNNIGGSVIEPITDAR SSNGENRCEEFLRKELYPNWQIRSSIISFCEKEAAEMKAETDQKFCNTGESAAKPIIEAR SENGKEKCKEFLKQELYPNWQIRSNIISFCEKEAAKMKNETDQQCNNNEKSAVAPIIDAR SA---GRCDQFLAKELYPNWSTRDQVLGFCENEMNQMKSELLREYGDESSMTKKSQLDSR PAQELARCVDYVGSTLLPAWHIRGQVIDFCATQASQIRA--SLQLGGDESHV-PAAVDPT SIDSRSQCKDFIHCELYPSWLVRNRIINFCDREASELKREIEAKYGTSNADL-IPEIDPR -----SKCSQYFEEEIVPQWRVRGEIIDYCSKYSQELRDHTATKLSYDLPNAETDKFDLR GAKAKANCQKFVHEELFPSWGLREAAIRYCEREAQSLKQELDAKYGNSPQLQ-QPVLDAR -----KECDNYFESKIVPQWEARASIIQYCNDYAIHLRQET-TKGNTVMQSSKLESFDLR -----SKCTQYFEEEIVPQWKIRGEIIDYCSKYSKELRNHTPTKLSYDLPNAETDKFDLR ------------------------------------------------------------ -----SECSSYFQDEIVPQWKLRGDIIDYCSKYSQDLRDHTVTTLSYNLDNAATEKFDLR -----SKCDEYFNRKIVPQWRARSEVITFCSNYAKEIRSKVELRKAEAHNDH-----DLR -----AGCDDYFASTIVPQWQARAQLITFCENYAADFRKKTEPQGGAAHDNLLPQTFNLR -----GSCNSYFRTKIAPQWKARQELIQYCESRGAELRHETDQQGSSAQ----KPDFDLT YEDSGVSCNKFLEKELYPNWKIRNNIIKFCDNEAKKMKEEIDLKNGSGSSAGIKKVVEAT TAAEQPACNEFVQEVLLPAWNERDRVLTYCGDVARLAKDKKGDMTEAAQTQDEKPAKRQP LDPYSVRDLQHEEEKKYKQWNDLNNWVENNRTIEGILRGSSDHFLKQNCDQNVDYLRKFW IDPYAVKDIISERESHYKDCNSLETWINNQKDIERIIQIRTSSILSEQCGNDRDYIQDFQ IDPYAARETLDDQEARYKDWTKVKDWVANNRQIEQILTSTTDRILRQNCEQNKDYLKQFA IDPYAARDQLDSQEAKYAEWKKVKQWVQNNSEIESILQGTSDKILRQKCNQNTDYLKQFY IDPYAARERAEKQEAQYKDWTKVTEWVANNRKIEQILTSTTEGILRQNCEQNNDYLKEFT IDPYAARERVEEQEAQYRDWTKVTEWVANNRKIEQILTSTTDGILRQNCEQNEDYLKQFS IDPYAAKERAEEQEARHRDWTNLTDWVANNRRIEQILTSTTEGILKQNCEQNEDYLKQFA IDPYAARERVEEQEARYKDWTKVVDWVANNRRIEQILTSTTEGILRQNCEQNDDYLKQFA IDPYASKDQLQERDTHFGKSTRLQTWLDNHKKVESIVRSNSDRVSKNICDENANYLEQFW VNPYVTVEEQERHRARLGDVMKMENWVANQREIERILQRTTLARVNSVCGQLDEFASQVQ IDPYAAREREEQREAHYNDWKRLKNWVQNQREVERILQIRSNNVLGEVCGHNTDYVEQFK TDPYAYKSYQRRIDEQYAQCDALDNWTQNEKTVEQIIRQQTVEVLNDKCFYQ-DWMQAFK VDPYAAADNFLQSEAHYKEWKELIRWTETQRKIESILQKNGSNVLNRACDPDTTYIEEFE VDPYAVKKYNQQLEGQYSQCNSIDNWVKNERVVEDIIREQTVDVLNDKCYYQ-DWIEEFK TDPYAYKTYQRRIDEQYAQCDALDNWTQNEKTVEQIIRQQTVEVLNDKCFYQ-NWMQAFK ------------------------------------------------------------ TDPYAYKTYQKKISEQFAQCDALDSWTQNEAMVEKIIREQTIEVLNDKCFYQ-DWMQAFN IDPYALKNELSQLEEQTSKCTTIENWIHNESGVEAIIRAQTADVLNDKCYYK-DWLAAFK LDPYAEKSYNQKLEQQYAQCDYIDNWVSNQKNVESIIREQTSHVLNDKCYYN-DWLAQFK LDPYVLKEYQRKLESQYSVCQTIENWVENEKGVESIIREQTSNVLNDKCYFN-DWMAEFK IDPYAARDFQEEEKSKYKELNNLIKWVENNNYIESILQNNTNSILQQNCNEDINYIEKFW LDPYAAEARTNQK----SDADRVLDWVETERTIEGIVRDTTRAEVYDKCGIS---LQ--- DLSSK---MIPEALRKQALIAYKHGLRATRVAFDGDNRVLLAARAEMRKGMENPDSSKTT NFIKTKN-------MSQALGAYRNGLRAARVAFKGDLRMLMAARQQMRESMVNPPNPELP QFCKDNT----MSTRLKALDAYRHGLRATRIAFQNDTKVLLAARAKMRSGMVSPPNPKLT DTFQKK-----MSLNGRALTAYRHGLRATKIAFNGDIRMLTAARVQMRNGMIDPPNPELS QFCKDNS----MSTRTKALNAYRHGLRATRIAFRNDAEVLLAARAKMRSGMLCPPDPKLT RFCKDNA----MSTRSKALNAYRHGLRATRIAFQNDTEILSAARAKMRSGMASPPNPKLT QFCKNNS----MSTRLKALNAYRHGLRATRVAFQNDTEVLIAARAKMRSGMLCPPNPKLN QFCKDNS----MSTRSKALNAYRHGLRAARIAFQNDTEVLLAARAKMRSGMLCPPNPKLT KFGQEH------------------------------------------------------ ALTDRRN----MSTSSRALAAYRNALRATKVAFGEDVRMLVAARKAMRHGML-APDASLP KFSKSI-----MSSSTKALAAYRNGLRATRIAFRQDIPMLLAARSKMREGMANPPSQELS RASNPKK-------MSSVLSAYRNALRATKVAFRQDLPILQAARVQLKQGIRDNSNLQAQ KFRKNLK----MSSSSAALSAYRNGLRAIKIAFNGDVRMLQAAQSQMRNGMVNPPNPELA KLKNLA------MSNIRALGAYRNALRATRVAFKTDLPVLMAARTQIKQGFVDNKDLADQ NASDPKK-------MSSTLSAYRNALRATRIAFRQDLPILQAARMQLKQGIRDNSNLQTQ ---------------MSAKLAYRNALKAINIAFKNDQPMLGAAKQQIRSGIMSNAQLTKP NAVFPKK-------MSATLSAYRNALRATKVVFRHDLPILTAARTQIKENIRNNSNLKDT KSV----------MSNPALQAYRTALRATRVAFNGDNFVLKSARAKIREGLLSNRDLADK KLDSVIK--MSISNVSAAKSAYRNALRATRIAFRQDVPVLSSARLQIKDGFTKNRELKDE RLNSQ--------MSSRALSAYRAALRATRISFQQDNDVLLAARKQIRDGFEASRNSDNA TFYNNKR----MSTSQRALGAYRHGLRAARIAFQGDTTMLNAARLKMRQGM-EKPNPELS --------------MSQGLTAYRNVLRAANLAFKNDHFVLGQAKANIRKGFEDGRKLDPK Q----EQIQHLEEVATFLKRNLVQGQK------IEGEEKYHLKIHKDIELGDNESIKQ-- P---DQQIKLMNDVAQFLRQNVVQGKR-------TKDDKYHLNIHKDTELGDNETIKT-- T---EEQVQHLEDVAVFLRRNLVQGQK--VNDTDMKEPRYHLNIHKDTELGDNETVPD-- K---EDQIKHLEDIALFLRRNVVQGVK-----TPQDEARYHLNIHKDTELGDNEDTKI-- T---EDQIQHLEDVAVFLRRNLVQGKK--VDGSSTKEPRYHLNIHKDTELGDNETIAD-- A---EEQIQHLEDVAVFLRRNLVQGKK--VEGANMKQPRYHLNIHGDTELGDNEAIAD-- T---EEQIQHLEDVAVFLRRNLVQGKK--VDGTNTKEPRYHLNIHKDTELGDNETVAD-- T---EEQVQHLEDVAVFLRRNLVQGKK--VDCANKKEPRYHLNIHKDTELGDNETVAD-- ------------------------------------------------------------ V---EDQITHMNDIATFLRRNLVQGKK-----VSGKDDVYQLRIHEETELGDNATIKE-- V---DEQIQHLNDVALFLKRNIVQGKK-------DDQGKYHLNIHEDTELGDNESIKT-- P-EIEEAVQKLNEVAKFLIQNIVQGEK-------QQDGKYFLNFHEKTELGDNETIKQ-- T---DQQIQHLNEVARFLRSNIVQGKR-------KEGEKYELNIHKDTELGDNETVKK-- E-QQHEAIDKMNEVSQFLIKNIVQGEK-------QEGDKYFLNFHERTELGDNETIKQ-- P-EIEEAVQKLNDVAKFLIQNIVQGEK-------QQDGKYFLNFHEKTELGDNETIKQ-- E-EVAEAVKKLDEVSKFIRHNLVQGKL-------QEDGRYFLDFHKEIELGDNETIKN-- T-EIEEAVKKLNDVSKFLISNIVQGEK-------QDDGKYFLNFHEKTELGDNESIKQ-- M-EVEKKVAELNEVAQFLVKNIVQGEK------EEGKDRYLLKIHDKTELGSNETIKQ-- A-EISEAISKLNEVSKFLVQNIVQGEK-------QEDGKYFLNFHEKTELGDNETIRQ-- E----EEIVKMNEISKFLVSNIVQGEK-------QGDGKYFLKFHDQTELGDNETIKQ-- K---DQQISLMEDVALFLRRNLVQGKKKESTTTSDGKDVYRLNIHKDTELGDNDTVKN-- DEDVKVRLEHINGVAYVLRTQVVQGQK-----HNPDEEKYQLNLHKDSEMGDNESIKS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------PT-----KFKARPFK---------KCSDN---------------------- ---------TK-----K-TLAAQGGG-------CCGGGAGLYK----------------- ---------PT-----A-RVKTSLKARPF----KCSDRKH-------------------- ---------PK-----R-NTLTGGKTSPVGG--CCGGGA--------------------- ---------PT-----A-RVKTNLKARPF----KCSDKKQ-------------------- ---------PT-----A-KVKTNLKARPF----KCSDKKQ-------------------- ---------PT-----V-KVKTKLRARPF----KCSDKR--------------------- ---------PT-----A-RVKTNLKARPF----KCSDKKQ-------------------- ------------------------------------------------------------ ---------TK-----T-TLASQGGG-------CCGGGKDLYK----------------- ---------TK-----K-TLAAGNGG-------CCGGGKGLYK----------------- ---------GR-----K-EMGSLAGKKGSSIK-SCND----------------------- ---------AK-----K-TLTSQGGG-------CCGGGQGLYK----------------- ---------SK-----A-EMGSLAGARAK----KYSNIKK-------------------- ---------GR-----K-EMGSLAGKKGNSIK-SCKD----------------------- ---------SK-----A-EMGSLSGAKGKSIR-VAKCS---------------------- ---------GK-----K-NLGSLAGKKGSSIR-SCKD----------------------- ---------SK-----A-NLGSLAGAKVK----RCS------------------------ ---------GN-----KANLGSLAGAKVK----KCSDN---------------------- ---------NH-----KANMGSLAGAKA-----KCR------------------------ ---------AK-----T-TLKANGGVG------CCGGSGAASKS---------------- ---------PP-------PMPTKGK-KGKKVK-CCSE----------------------- -----------------------------------------MRDSVTLDKTAKMIGIRSV -----------------------------------------PVRLLPYSRTP--LTLAPR -----------------------------------------MQAKLFFTRLN--FRLPCS ------------------------------------------------------------ -----------------------------------------MQAKLLFTRLN--FRRPST ----------------------------------------------MLTRLS--IRLPFT -----------------------------------------MQTKLLFTRLR--FRLPPT ----------------------------------------------MFTRLN--FRFSPT ------------------------------------------------------------ ----------------------------------------------MFKRILRPPAGLPR ------------------------------------------MIAKLFYGVPKISRAARP ------------------------------------------MLGTKYFAISTLKSFKPL ----------------------------------------------------MLHKFTIE -------------------------------------------MISKFIQRN--VVIPTT ------------------------------------------MLGTRYMVITQLFKSPIL -----------------------------------------IIARQLLTKSSAIRSYKCS -----------------------------------------IMISKSIKHIRIIPKGLTY ------------------------------------------MIPRGVRIYSPLLRVTCS ------------------------------------------------------------ -----------------------------------------NVAKRQIFQVS--FCSRCL -----------------------------------------MYRSISFVPRRIIYQRRSI ----------------------------------------------MFRRLLAKSSLRTV TVSRISVRGYARVVSKAMAKPMAKPMMNTMQNTRWYGIKVEASEGEVPLVEPYKVLNKQE ILNQVPVR-------AALGVRWQSSSPSSILDTPI---------------RPAKIINEVP SFHRFPARRFP-----------LQKSFYSELAAKE------------PLISPERIINKTP MLRSSALR------------------LYSTLATKP------------ILIQPTRIINRIP TLRQFPLTCFL----------FHSKAFYSDLVTKE------------PLITPKRIINKTP TLRQFPLRCFP-----------LQRTFYSELATKE------------PLIIPKRIINEAP TLHHFPLRCFP-----------LQRSFYSDLAINE------------PLITPKRIINETP TLRQFPLRRFP-----------LRKAFYSDLVTKE------------PLITPKIIINETP ------------------------------------------------------------ PLAFYSAARL-------RGLRWQSSANVLAGDGAG------------PLVTPTRVVNGDP QITSLIYR----------------TRFYSTLEDTP--------------IQPLKVINGKP TLGGTTIITLRYNSTSNANSSRLKPSSFAFPSSPTDSITSSQQQEDINDFRATKLIHGKT GLRPLVRT----------HRLWNSPSAFRFNSTSA----------LDSCVTPSRVLNAKP RQLIRPSMYLTYRHGSNTAPKAFKSSSFNQPKEIPQTQTAEVPQEDIDDFNITKLIHGTT NGTVIGTLRYNSTKSTGTNSSRLKPSSFAFPSAQPNDSTTTLQQEDINDFKATNLIHGQT QSAVLLHKRFNATATIKSQPKTLKPSAFAFPSEPKPNQNEETIREDIDDFRATKLVHGET PIINITPIRYN-------TTKILKPSSFSFPSNSPQQQQQEEVEKFKDDFKYTRLIQGKT RIVQYPILAYSQTAT--STPKSLKPSSFALPKDVPDTETGPEKSDDSRYFQLTKIVSGHT -------------------------------------------QEDIDDFNATKLVHGKT LRQRIPPLSFRANST---STRSLKPSSFSFPSKDQ----------PVSDFNVTKLTHGKT PLFPVVLRNYS-----------NTTSNESIPNDE-------------PLVTPLKIINGNP PRLGSPSL-------TQRHFTASARRLFEFPESVP---------REKIEEDAVTIVNPQK DKGLKIAERAAKRLNEI---YKESQEVLRVLVESGGCHGFQYNMKLVPESSLEETGNSEF DLHFSITNRASKRLAEI---YKASKEILRVTVESGGCHGFQYNLKLVPESKIGNQEQEDL GLNLSISERASKRLAEI---CRDSKENLRISVESGGCHGFQYNLTLEPAFDGKRSVRNEF DLNIQITQRAASRLNEI---YKASNEVLKIGVESGGCHGFQYNLDLIPADNLDDEFAE-- GLNLSISERASNRLAEI---YRNSKENLRISVESGGCHGFQYNLTLEPATDIKNDVKDEF GLNLSISERASQRLAEI---YRDSKENLRISVESGGCHGFQYNLTLEPASTIARDKDKEF GLNLSISERASNRLAEI---YRDNNENLRISVESGGCHGFQYNLTLEPASDMKTDAKDEF GLNLSISERASNRLAEI---YRDSKENLRISVESGGCHGFQYNLTLEPASDVKNNVKDEF ------------------------------------------------------------ SLRLNITQRAAQRLGEI---YRSSGEVLRVGVESGGCHGFQYNLALQPRPESQPSGADEF DLKLAITQRAANRLAQI---YRDSQEVLRVAVESGGCHGFQYNLKLVSKDDIKLNSEDEF NLSFAITERASKKLNEI-SQQDNQDSGLLIQVESGGCHGFQYNLKLT---NIDKELQQ-- GLSIGITQRAANRLGNI---FKDSKEALRVSVESGGCHGFQYNLKLIPRENLENPAPTGE DMKIAITKRASNKLTSIAEDDKNPNAALKVEVESGGCHGFQYNLKLT---DLTEELKD-- NLSFAITERASKKLNEI-SQQDNEDSGLIIQVESGGCHGFQYNLKLT---NIDKELQE-- NKVIAITERALLKLNDI-RTSNPKDSALQIQVESGGCHGFQYNLHLI---DLEQFLKE-- DLQLGITERASDKLNQIKKDDNNENSGLLIKVESGGCHGFQYNLKLI---DISKDLN--- DLKIAITDRAMKKLTEIAESDQNPDSALKIKVESGGCHGFQYNMDLT---NVKDELS--- DMQIAITKKASEKLNKIAVDDNNINTALKIGVESGGCHGFQYNLDLT---DLEKELAQ-- DLEIALTERASKKLCQIAKEDKNPRTALRILVESGGCHGFQYNLNLT---TIDDAVAE-- KLNLKISERAARRLSEI---NKTSNEALQISVESGGCHGFQYNLKLIPKTQVSDSKLEED DLRLFVSDRAATRLNAISEDDKNPLLALRIEVESGGCHGFQYKLELS---DVEDV----- AEGSSSKDVIYIVSEEGG--KVAIDETSLGILNNTTLNYTTELIGSTFKITDGNL-KSSC NDEETVKDIVYVLPDSIG--EVVIDEQSLKILNDTTLTYSTELIGSTFKITGGSM-TSSC SDSDDSKDIVYVLPEDKG--RVIIDNKSLEILNNTTLTYTNELIGSSFKIINGRL-KSSC ---NNDKSVVYVMPPDGG--KVIIDENSLKILNDTVLNYTTELIGSQFKIEDGNL-KSSC SDDDDSKDIIYVLPEDKG--RVIIDSKSLNILNNTTLTYTNELIGSSFKIINGSL-KSSC LNDDDSKDIVYVLPENKG--RVIIDNKSLDILNNTTLTYTNELIGSSFKIINGRL-KSSC SDSDEPTDIIYVLPEDEG--RVIIDNKSLDILNNTTLTYTNELIGSSFKIVNGRL-KSSC SDDDDSQDIVYVLPEDKG--RVIIDNKSLNILNNTTLTYTNELIGSSFKIINGRL-KSSC ------------------------------------------------------------ DEF--RKDIVYVLPEEQG--EVVIDHASHEILNNTTLTYTTELIGSTFRIIGGKM-TSSC DDDEANNDIVYVLPKNQG--EVVIDENSLKILNNTTLTYSTELIGSTFKINGGSM-KSSC ---DGDANDLVVFERDQGG-KVIMNESSLMILQDSKLDYTKELIGSQFKIVDSPYTSSAC FEEDTNFDVVFELPGDGG--QVVIDEKSLNVLNKTILTYTTELIGSTFKITGGNM-KNSC ---ENNELLVFKRMGDDGEVQVVLDDSSLQILQDSKVDYTKELIGSQFKIVDSPYTSTAC ---VENNDDLMVFERDQG--KVIMNESSLMILQDSKLDYTKELIGSQFKIVDSPYTSSAC ---TEDPEDVFVFAREEGNLRLVLDDSSLTILQDSKVDYTKELIGSQFKVVDSPYTSTSC -----PSDEIFIFERNGG--KVILDESSLMILQDSKVDYTKELIGSQFKIVDSPYTSSSC -----KNKDLVVFQRSDNDKKVIFDESSLEILQDSKVDYTKELIGSSFKVVDSPYTSTSC ---EDDELLVFKRIDESGNIQIILDESSLEILQDSKLDYTKELIGSSFKIVDSPYTSTSC -----PEMLVFQRQTDDGVANLAIDESSLEILQESKIDYTKELIGSSFKVVESPYTSTEC DNDTDNKMIVFIIPENDT--KILIDEKSLTILNNTYLTYTKELIGSSFKILGGSL-KSSC -----DFEMDSVFEKNGA--RILIDKSSLEILRESNIDYTTELIGSQFKVVDSPYTVSAC GCGSSFDIEKFLKKKPDVLGTLEVSKFMEHFPKKKTINKLLFDLNSRLTYKKLYPIYVGL GCGSSFGLDQMLGFRSRRLISSLANRLHEIFPQKKMVSRILFELDSRLAYNKLYPMYEKL GCGSSFDIEDMQRFVSRLVSAPRISKFLECFPKKRTINKVLFQLDTRLTYHEMYPIFVQV GCGSSFDADVMNRVIIRRIATKSTSLFHEIFPRKRLINRILFELDSNDTYKTLYPNFETL GCGSSFDIENMQRFVSKFVSTPPVPKFQEIFPKKRTVNKILFQLDTRLTYHEMYPIFLQV GCGSSFDIESMQRFVSMLVSKRRTPKFQEIFPKKRTINRILFQLDTRLTYREMYPIFVQI GCGSSFDIESMQRFVNRFVSTPRISKFQEFFPKKKTINRVLFQLDTRLTYREMYPIFLHV GCGSSFDIENMQRFISRFVTTPRIPKFQEIFPKKRTINKILFQLDTRLTYREMFPIFLQV ----------MSRFIAKCYSTASSSRFHEVFPQKRTVNRILFELDSKHTFGKLYPVYDNI GCGSSFDFDGPLRLICRFLSTNN--RLHKIFPSKKLVNRMLFDLDSRLTFRKLLPVYEQV GCGSSFDIDVGIPIIWKRLISHNASRFYDVFPQKKLVNKLLFELDSRLTFPKLYPLYESL GCGSSFDFDFMIRQFLRNASSNATKRLLTILPSKRILNRILFDIDSQLTYKQMIPILNHI GCGSSFDVDVPGKMLLTRLASSLAKRFYEVFPQKKMVNKILFQLDSKLTFPKLYPVFESL GCGASFDFDFMIRNLIRWYSSATHSRLSNLLPGKRTMNKILFDNDSRLSYKKVIPILNSV GCGSSFDFDFMLRQFLRNASSNPTKRLLTILPSKRILNRILFDIDSQLTYKQMMPILNHI GCGASFDFDFMLRIFNRGATILASTRLSTILPSKRTINRILFDCDSNITYSKMMPLLTHI GCGSSFDFDFMIRQI-RYASTVAATRLLSVLPSKRTINRILFDNNARLTYKKMIPVLTNI GCGSSFDFDFMLRNFVRHSSSA---RLSTILPKKKTINRLLFDADARLAYSKMLPILNSV GCGASFDFDFMIKWTVRYNSTASSLRLLLILPKKRTLNRILFDNDVRLSYSKTIPVLQLI GCGASFDFDFILRTWVRGVSTVSSRRLSTILPAKKAINRMLFDNNTRLSYKKMIPVLESI GCGSSFDIDHMLRFQVRQYSNVSSIRFETVFPKQKFIKKILFDLDSRLTYSKLQPLFKYF GCGSSFDFDE-------------------------------------------------- YHGVPVPQQQKLLDGVKGSDLIVMRNVLEKVRNRTRYARPDMLKLEDKLLELAAELGNND YEGLDTGNDVDIPNSIKGKDLMIMKKVLEKVRHKTKAINKNLLALENVLLDRAAEIGDND SQLTNKESIPKKYPYLKSSDIMQMRNVLVTLRMQNKFVHKDVLAMENKLLNIAAELGNND YLKH------ELPSTVSGPQLLLMDRVLLEVSKQQKMINEVLMKMRGELLELAAGKGEND SQNTNEENIPKKYPYIRSSDIMQMRNVLITLRTQNKFVHKDLLAMEDKLLNIAAELGNND SQSSTEEKIPKKYPYIKSSDLIQMRNVLITLRMQNKFVHKNLLAMEDKLLNFAAELGNND SQTTNEESISKKFPYIKSSDIMQMRSALITLRMQNKFVHKDLLVMEDRLLNIAAELGSND SQTTNEENVPKKYPYIKSSDIMQMRNVLITLRRQNKFVHKDLLAMEDKLLNIAAELCNND YQNMQKGIDTXIPKGISPSDLMIMKKVLEKIRHRTKSINPHLLALENALLDRSAESGNND YTQLDSSTGDVVPRGVRAHDVMIMKKVLEKTRRRTKSSNRHLLALENELLYMAAQMGHKD YNTMDDAQSQKVPTSVTASDIMVMKKVLEKLRHRTKSINKNLLALENEILNKAAEMGNND YKNLSTPESILNQLKIQSSDLMKFKKLLQEIRKVTNSIDVHLLDLENELIEQSAELGNND YDNAGNRDPSLIPTSFKASDVMIMKKVLEKIRHRTKSTNKNLIGLENELLETAAEMGDND YSHIETPEDIILPNYVKSNDLMLCKQILASIRSTTNSINKNLVLLENELVEQAAELGNND YNNLSTPESILTQLKIQSSDLMKFKKLLQEIRKVTNSINVHLLDLENELIEQLAELGNND YDNLATPSKIEIPRNLKSFDLMVFRKMLTTIRSQTQSVNKNLVALENELVEQSAEMGNLD YENLNTPEKISIPQFVQGSDLMDFKKMLSTIRKLTNTTNKNLVNLENELIEQSAELGDLD YTNLDEPEQIRLPPYTKHDDLMILRSILHNLRSVTNSVNKNLVDLENELVEQAAELGNND YKHLDTPEEIRLPKFVKAIDLMKLKSVLTAIRTTTNSINKNLVALENELVEQAAEFGDND YDNLDSPEKIQLPRYVQHNDLMQFKEMLAMVRSSTNSVNKNLARLENELVEQAAELGNND YENMDNDEVEKLWKGITGDDLMLMKKVLERTRRKTKATNKHLLVLENSILDKAADVGNQD ------------------------------------------------------------ AIAILSFRSIRNAAENEEVTIAKKLFKDLYNINHLLAIKLLGDLALEANNWEEALTFYNK AISLLCFDVLKDDSNEDDVSHAKKLIKNLYQMNHPLTVKLTADIALKNHDDATAEVYYMK AISILSFNAVKNKDNQNDVETANRFIKELYARNHHLTIKLIGDTFLKNKAYDKAEKYYKE AISTVCYNILSSKDDKGDAEDASRLIGELVKAGNVLTFKHLGDLSRLKGDINEAKLWYDK AISILSFNVIHNKSSEKDIETANEFIKKLYARNHHLTVKLIGDLFFENKTYDKAEKYYQE AISILSFNAIQNKYYQNDVETADRFIKELYARNHHLTIKLIGDFFLKNKAESKAEKYYKE AISILSFKVVHNEYKENDVETANRFIKKLYARNHHLTIKLIGDLFFEHKTFEKAEKYYRE AISILSFNVVHNEYNQNDVETANRFIKNLYARNHHLTVKLIGDMFFENKAYDKAQKYYKE AISLLAFDVLRDGHNPEDVDYGKK------------------------------------ AAALLAFDTLCNASQAADMEYAKLMVKDFYRSGHPLTLKLTGDLSLANGDNTTAEEYYMK AISLLAFDTLKDDSNHEDIAYAKTLIKELYQLRHPLTVKLTGDLTFKNNDLINAEKYYKD AITILAFETVR-KRQEEDYQHANELIKQLIDINHPLVFKMAGDLSWELNQPNQAIEYWQT AIALLAFSFLKNGKHPEDVLHAKNLIKELYQLQHPLTIKLTADLAVKSNHFEDAERYYLH AIAMLAFESIEDQTSKEDYKYANKLIDNLTNLKHPLVFKMAGDLAFKKGYHNQAEIYWLQ AISILAFETIR-KRQEEDYKHANELIKQLIDINHPLVFKMAGDLSWELNQPNQAIEYWQN AIAILAFETIRNTKQKEDFQTANKLVQELTEMKHPLVFKLAGDVALERNYWDRAHDYYLQ AITLLSFETLAKDKTMEDTKHANKLIKELVELKHPLVFKMAGDLAWSKNAHVQAIDYWKQ AIAMLAFESIASDTSPEDYEYANGLIRQLTERKHPLSFKLAGDLAFSKNYHAQAAQYWHE AIAILAFETIGEKVSKEDYDYATKLVKNLTELQQPLVFKLAGDLAFKQKYYEQAAQYWLQ AITMLAFETIRKDVNKEDYQYANSLIEELTNIKHPLVFKMGGDLAFEKKFYPQAEQFWKN AIAILSFDVLKDKNSDEDIDYARMLTKQLYKSQHPMTIKFIGDLSLRQHNDVEAEKYYKK ------------------------------------------------------------ YINLTGNDDLTGEVYGKLGEIEFTYANMTKAEEYWQKCLELTSVEDSVRWYFLAAQIYMS FLDLQNDTFLAGEVYGQLGQIHFRKPNLIEAEKCFLKSIKLCPIDYSVRSYFLLGQMYVN FLKLENNTKLAGEVYGNLGEIQIKQNGFLKAEKSWLKCIELLELERSSRWYFLLAKLYLS FMERVSDVSIIGQVLERLGEIEFNQR-VLGAEKYWLDAIARSKLEDSVKSYFYLSKVYLN FLKLENSTKLAGEVHGKLGEIQIKQNGFLKAEKSWLSCIELLEIERSSRWYFLLARLYMS FLKLESNTKLAGEVYGKLGEIQIKQNGFLRAEKSWLECIRLLELERSSRWYFLLAKLYLS FLKLENSTKIAGEVYGKLGEIQIKQNGFLKAENSWLKSIELLEIERSSRWYFLLAKLYLS FLNLENSTKLTGEVYGKLGEIQIKHNGFLKAEKSWLKCIELLEIERSSRWYFLLAKLYLS ------------------------------------------------------------ FLKKEADTFLAGEVYGQLGRISFLRSHFAQAEERFLQAIKLTPLEYSVQSYFYLGQLYMN FLALEDDTFLAGEVYGQLGQISFRKPNLFKAEDYFLKSIKLCPLEYSVHSYFYLGQMYMN YIQLASNKNSGGQIYYNMGYYYFTYPNLTLAKLNFQKCINHG-FGFIVKSHFYLGQLYVN FLELESETPRAGEVYGQLGLIYFRRPNLKEAERCFLSSIRLCPLEAVTHSYYHLAQLYMD FIELELDTILASQVYANLGIYYFNYPDLTKAELYMKKSIKFGELDYTIQAHYYLGQLYSM YIDLVNKDKRGGQIYYNMGYYYFTYPKLSLAKLNFQKCINHGSSNFIVKSHFYLGQLYVN FLEVEDDTIPAGHVNYQLGYYYYANRDHEKAKQYFERCLKLTELDYATKAHFYLGQIYLN FIELEPTSELSSQVYFNLGYYYFTFPDLVSSKLYFEKSINVGDINYTIKSHYYLGQLYVD FLDLEDKTVLASHVHSNLGIYYYHYADLVRAKMHLEKAICFGELDHIVKAHYYLGQLYTI FVDLEPDTILASQVYANLGLYYFTYPDLHLAKKYFEKSIAVGELDFTIQSHYYLGQLYTT FLDLESNTILAGQVHAKLGAYYFQYPNLTLAKMHFEKSIKLGEFDHILQSYYYLGQLYST FLELEDDTVLAGEVYGQLGELYFRRANVFKAEEHFKKSVKLTPMDLSVRSYYYLAQINMN ------------------------------------------------------------ SEPLKSRILLEKAASQGFKESLTSLGFLEMNYFRDYGRAKEWFKLGMEVFELQSYIGFFD NDIFKARYLIESSATQGFKESFRTLGLLEMNYFKNYPKAQEWFKLGMELYDTECFVGYFD SEPLRAKPLLESCASIGFKECFKTLGFLELNYFQNYERAKEWFKLGMEITDLECFLGFFD SEPLKSRVLLENCATQGFRESFKELGYLELNYFKNLVKANEWFRLGMELFEIECFFGFFD SEPMKAKALLENCASIGFKECFKTLGFLELNYFNNYERAKEWFKTGMEIMDLECFFGFFD SEPLRAKPLLEKCASIGFKESFKTLGFIELNYFQNYERAKEWFKIGLEIMDLECFLGFFD SEPMRAKALLEKCASIGFKESFKTLGFLELNYFQNHERANEWFKLGMEIMDLECFFGFFD SEPMKARALLENCASIGFKESFKTLGFLELNYFHNHERAKEWFKIGMEIMDLECFFGFLD ------------------------------------------------------------ SDPLKARSLLESAASQGFKESFKTLGHLEMNYFCDLTKAREWFKLGMELGELECMIGCFD SQPLKARALLESTATQGFKESFKILGFLEMNYFEDYSKAQEWFKLGMELFEMECFVGYFD TNPKLSKYHWEISSSSGLKDSIINLGFLEMNCFQNYNLAIEWFKLGVELNEVQCLIGLFD SEPLKARSLMESAASEGFRESFQLLGFLEMNYFHDYAKALQWFRLGMELYQFECYIGYFD TDPILSKYHLEISASKGLKESFPSLGFLEMNIFKNYSKSLEWFKLGVESNDLSCMIGQFD NNPKLSKYHWEIASSSGLKDSIINLGFLEMNCFQNYHLAIEWFKLGMELSEVQCLIGLFD NNVARAKYHWEIAASKALAESFSSLGFLELNKLNNPQIAIEWFKIGVEASDIVCLIGQFD NNPKVSKYHWEISSSKGLKESYSSLGFLEMNVFNNYNQAIEWFKLGTELNDMTCYIGMFD TDPELSRYHLEISASRGLQESFPSLGFMELNVFDNVPKALEWFKLGVEASDLACLVGQFD IDPQVSKYHWQISAGRGLKESFASLGFLEMNVFQNYDKAIEWFRLGVEANDVSCSIGQFD TDPTLSRYYLEVAASKGFKESFASLGFLEMNMFKNFSMSMEWFKLGVEANDVSCLIGLFD SYPQLARTLLELCATQGFKEAFRSLGYLEMNYYNSNDKAYEWFKLGMELYDVECYFGFFD ------------------------------------------------------------ CCVKNEDWIAALKCLKSIEKIGSDNATVSNFMNSRAEFIDKVR---MLVPPASFGIAEEG CTMKNNELLLAKRCYESMEKLENNQRLFEDFSSHRASDIQKIK---MLVPPANFGIPEEG CCLKLKDIGSAKNCLKSLKIFEDDGLVVDAFLESRKDSMKLLK---MLVPPANFGIAEEG SCYQLKEYKSCSKCLKSLETFNINENMVSEFVSHRENKINNMN---MLVPPANFGIAEEG CCVKEENFKGARDCLESVKKLGNDKTMINVFLESRKDSIKLLD---MLVPPANFGIAEEG CCLKLKDTSSARNCLESLKKLESNNAIINTFLESRKESMKLLE---MLVPPANFGIAEEG CCLKVGNIVSARNCLESLKKLGSDDTIINTFFESRKDSMKLLE----------------- CCLKVKDIKGARDCLESVKKLGNNDPMIDAFLESRRDSIKLLD---MLVPPANFGIAEEG -------------------------------------------QSTMLVPPANFGIAEEG CAITLGDLALAHRASKSLEALKTDKALYTQFADYRHEKLSLLE---MLVPPANFGIAEEG CCVKLEEWVNAKRCFNSMTTLQSNTPVYSNFVTTRKDKLEKLE----------------- AYIALQNWKSANIYLSKLNKLETITSMLKTFHETRLNDIKLVT---MLVPPENFGTVESG CSIKMQDLKKARNCLTSLQKLKTNDSAFKSFVDSRQETINKVN----------------- CFINLENLIQADGIYRNLVSVNKIRSLLNLFFSTRSGSIKSLP---MLVPPDNFGLVEPG AYIALQNWKLANIYLSKLNKLETIASMLKTFHQTRLNDIKLVT---MLVPPENFGTVESG CFYKLGQWNDCKKVWQNMHDLQKMNELLSAFFKGRNEEFQRLE---MLVSPENFGVVEPG CNILLKNWKSANITLAKIYDIDKIESVILTFLETRKNDINLVH---MLVPPENFGIVETG AHVRAHKQTHALNVLSNLQHLDKLD---KVLLAGRS----------MLVPPDNFGLVETG AYLKLLDYKLAYEVLSNLNSITQIQSLLEVFYRTRSSDISLLP---MLVTPDNFGLVEPG SYVGTKELSGARKVLKSLLNLQKVKSMLQVFFRTRKDSIAQLQ---MLVPPENCGLVEPG CCLKLKDTKSAILCIKSLEKLEVNFPLIDIFLASRESSIKKLK---MLVPPANFGIAEEG ----------------------------------------------MLAPPEYFGVVEDG IYRCSKVETLNLSFLEGLNLKTVIFVGGTEPSKFFKEFFTRSSIEWTAIRTADFSTVGSP IYRCSKLETINLSFLETLNLNTIIFIGGQIPSNFFKEFFATNGIDYFVIKTSGDSSSLVA IYRCSKVETLNLSFLETLNLKTVIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVP IYRCSKLETINLSFLETLNLKTMIFIGGQEPSKFFKEFFNRLSIKWYLIRIADFSAATSE IYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVP IYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVP ------------------------------------------------------------ IYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVP IYRCSKVETLNLSFIETLNLKTVIFIGGQEPSKFFKESFNEQSIKWYSIRMSDFSAAGKP IYRCSKIETLNLSFLEVLALKTIIFVGGQEPSKFFREFFERYNVQLFVIKRAQNSSLVLP ------------------------------------------------------------ IYRSTKLESENFPFLQTLNLRSMVILDTEKPPRSLNNFLEANSLQFFNLGGMKISNHQHT ------------------------------------------------------------ IYRCSKLEPEHFPFLETLQLKSLVVLDAEKPPRLLKNFIEANNIEIHNLGGLKISNHNHT IYRSTKLESENFPFLQTLNLRSMVILDTEKPPRSLNNFLENNTLQFFNLGGMKISNHQHT VYRCSKIEVENFQFLETLTLKSIVVLDAEKPPRSISNFLETNKIELYNLGDLKISNHQHT IYRSTKLESENFPFLQTLDLKSIIILDTEKPPRSLSNFLENNSLQFFNLGGLKISNHQHT IYRCSKLEADHFPFIETLQLKSLVLLDAAKPPRTLKSFLLKNKVDLYNLGGLKISNHQNT IYRCSKLELDNFPFLETLQLLSLVLLDAEKPPRALNDFILAHKIELFSLGRLKISNHHHT IYRCSKLDQDNFPFLETLNLKSIVIVDAEKPPGPLKRFIEANNVELFNLGALKISNHHHT VYRCSKVDTLNLSFLETLNLKTVIFIGGQDPSKFFKEFFKSSNIKWHIIRNSDFSGNVET VYRCSALTTLNFAFLETLGLKTIISLNPDRPPKHIRGFCSEQDIKLAHVGLRPWRA---- LKNDLSLVSPHSDEDTQSRESLGEDGESIHSGTSLTIGMNKKMAYHFSDSDDLMLIKSKS PDHKKRQSSANH---------GETRRKSLCDNC--------HYSYTLTDQDDLMLIKSQS VKSSSAPNGNLYPNNNSNQSLLDEKKTENSKMSQNSSTGPIEVSYHLSDNDDLMLIKSTC PPINNNSNSLMDKDNMRTSTEPMVKKTNSNDSIMNTINEGKESIYHLTDGDDLMLIKSTC VKSSSVSNANLYSNNNSTLSLQEEKKKSTANGSQNSTTGDPELAYHLTDNDDLMLIKSTC VKSSSASKSVSHSNNNSISSLQDEKKTNYSNVSQNSVATDPELSYHLSDNDDLMLIKSTC ------------------------------------------------------------ VKSSSVSNANLYSNNDSTLSLQDEKKKTTANASQNSITVDPELAYHLTDNDDLMLIKSTC ISSGNKSPSVENRKDDHKKHASHSKTSSVDSTKG-------DESYHLTDSDDLMLIKGSC GSNAQKEQPQAD--------------TAVSSGCQS------STHYKLSDADDLMIIKTHS -----------------------------------------------------MLIKVRS GIVSKGDQDDVD----------MARGTSLSLNTPKNF----FSSISLNRKDQWMLIEKNI -----------------------------------------------------MIIKSYS GANSSSNKDDNEDDANTETSSVSSKTETGVYNLGKSEIET-VKLTSKSKNDQWMLIERNI GIVSKGDQDDVD----MAMQEAQSKGTSLSLNTPKNF----FSTISLNRKDQWMLIEKNI GILSKTDIEDYDESTTSVASNADKDGSFTATATAASTNTSNIAALSRKSRDQWMLIEKNL GITSKVDQEDID-------RDVELRINNFSFNTPKTF----ASTISLTRKDQWMLIEKNI GGNSRESTGSDVSDGSGIPDIIESKPLDEIEIV--------QVNKARSKNDSWMLIEKNL GAEVSNSKDEDDDDDTLSTSSKGSDKGSTSINTQLEESKNASLNINKNKNDQWMLIEKNL GVNSSSGKLEEE---------GSSNGSTSSSGNADVNDLEPNVNTTKDKNDSWMLIEKNL ITPKSKSSS---SNNASGRTDLEGKKDSVETSRK-------RETYYLKDSDELMLVKSNC -------------------------------------------------SSNALVLSEDL LQRIFEKLLDRKNYNTLLV-----DKTSLVIGILRKIQKWNISSIINEYRLFAG-KNRGY IRRIFRILLDVSYHNVLLV-----DKTSAVIGILRKIQKWELSSIISEYRLFTG-KNKNY LKRTFKTLLNIDNYSVLLV-----DKTALVIGILRKIQKWNIASIINEYRLFSG-KNRNY LKKTFQYLLDVDNYNTLLI-----DKTALIIGILRKMQKWHISSIINEYRLFTG-KNRSY LKRTFKTLLNVDNYNVLLV-----DKTALVIGILRKIQKWNIASIINEYRLFSG-KNRNY LKRTFKTLLNADNYNVLLV-----DKTALVIGILRKIQKWNIASIINEYRLFSG-KNRNY ------------------------------------------------------------ LKRTFKTLLNADNYNVLLI-----DKTALVIGILRKIQKWNIASIINEYRLFSG-KNRNY IKSAFQLLLNKERHNILLV-----DRTSIIVGVLRKIQRWNISSIINEYRLFSG-KNRSY LQKIFRLMLNTTNHNMLLV-----DKTSIVIGLLGRIQKWNISSIISEYRLYTG-KNSNY LKVIFKLLLDTKNYNTLLV-----DKTSIVVGMLRKIQKWSIFSIVNEYRLFTG-KNSSY VMKAFEIMFNKKNYPLLII-----DSSATLIGVLRRIQKWNFNSILNEYRIYSGSTKNNY LKRAFELLLNTVNHNTILV-----DKTSIIVGILRKIQKWNIASVINEYRLFAG-KNCNY IAGAFELLLNKSKHNILLI-----DSTSTLVGILRKIQKWNFNSIINEYRIYSGSNKSNY VMKAFEIMFNKKNYPLLII-----DSSATLIGVLRRIQKWNFNSILNEYRIYSGSTKNNY IVKSFELIFNSRRHPLLIV-----DSTATLVGILRKIQKWNFNLILNEYRIFNSSNKNNY VLKTFEIMFNKKNYPMLVI-----DSSATLIGILRKIQKWNFNSILNEYRIYSGSTKNNY IMGAFEILLNKTKHNLLLV-----DSSSALVGILRKIQKWNFNSIVNEYRIYTGLSKNNY ILRAFELLLNKHKHNILLV-----DSTATLIGILRKIQKWNFLSILNEYRIYSGSSKNNY ILRAFELLLNKTKHNLLLV-----DSSSTLVGILRKIQKWNFNSIVNEYRTFAGSTKNNY LKKAFNMILNTNNYNVLLV-----DRTAIVVGILRKLQKWNIASVINEYRLFAG-KNVNY LQDSFDYVLDKTSYPILIL-----DSTNAFVGALRRMLKWNYSSVVAEYRIFSG-AKPHY FAETFLEMIQIKIEQTIEERS--LDEQQIDTIVSEEQ-LPCVEHKSNPVEL--VDEDLLC FAETFLELIDIRLIQEEEQPNQQTVTSRMDNLSVEEK-------QQEQQQIQTVQESDLS FAETFLEIISISIEQEKCNKT--NTNKNTKRLSLENNKTHSIEYKANSGKLIKVYESDLC FAETFLEIIELVVRQQRINDTTKLKDKDKNILPMEKNKNSKTSSKGKSSNFTIINEDDLC FAETFLEIINIEIEQEKDNKT--IVDNKAKKLPLENNRTHSIEYKANSGKLIRVNEDDLC FAETFLEIICINIEQEKDDKT------IVKRQSPENNRTHSIEYKANSGKLIKVNEDDLC ------------------------------------------------------------ FAETFLEIISVDIEQEKDDKT--IVNNNAKKYSLENNRTHSIEYKANSGKLIRVNEDDLC FAETFLEILQVIIEQEKEDDS--MME-EMQGLELGEN-LKRLHDHRKLSNAIVVYEEDLD FAETFLEVVDVTVTQDLEK----SVTEDIAKLDIQD--LRPIELFLNGSASRWSTSETSL FAETFLELVNIKVVQEQEDKL--IED--VNNLSNNQN-LMPADMVRRASTQEIVNETDLY YAETFLELVQVELIAYEHHSTSRDTDNGDLSETSDVNDDYDAIEDEDDEDLDDLDDELLS FAETFLEMVSIRIIQEEENGG--LKS--IEG-SNAVD-ADDLNESKSCAKWEIINESDLS YAENFLELLQTELIPFEIDRLNARTQASIFRSPFQISHQFDDENDNESIDDEDIDDELLS YAETFLELVQVELIAYEHHSPSRDTDNGDLSETSDVNDDYDAIEDEDDEDLDDLDDELLS FAETFLELISIELIPYENRKRSPISSAQIYSTDIDDDEEDDSEEYDSMDDMDDMDDELLS YAETFLELVQVELIPYEHQSRSRDLENGEISEASDANYEAVADDDEDDDFYDDLDDDLLS NVEVFLELINVELIPFEVNQCQESIDEGAITGE-------DEEALSLNDFEDDMDDDFLS FAETFLELIQTELIPYEIDQLNQQQQQADFKLSPEFLEEIWDEDDVNSIDDDDMDDDLLS FAETFLELVEPELIAYEIHRFNSRESRNASRTSVDDESFDDRNSDTQSIDDDEMDDELLS FAETFLELIELSIEQEIDDD---MITQRIRELQLAKN-LPEALVRCKSESMEMVNEDDLL MAEIFLEMIDIKCVAWDGECA-----------------------VTDDEEDIKSSSGGQF DEPEVPERQLHIVEEAERKNRIKDIPRVNNILISDTSTSSSDLGIFGHRYRLAFTQKEQG MPPELPQHMMSMIHTME--LKPEEDAKEHEL---PIKHSRSALGIFGNRYRLAFNKRERN KEPEVPQRLLTLINQIETKVKNNKVSQINGILRDDLKKTSSDLGIFGHRYRLAFNKKENG KDPEVPKRLLKIIEDAEARLREKDDELSKEIPPAEMIRTTSNLGIFGHRYRLAFNKKEND REPEVPQRLLTLINQIETKVKNNKVLQVSGVLGDDLKKTSSDLGIFGHRYRLAFNKKENG KEPEVPQRLLTLINQIETKVKNNKVLQVRGIMRDDLKKASSDLGIFGHRYRLAFNKKENG ------------------------------------------------------------ REPEVPQRLLTLINQIETKVKNNKVLQVSGVIGDDLKKTSSDLGIFGHRYRLAFNKKENG KPIEVPPRLLRIVDEAEKRSQLSSSAQDPNTNPSTMTRTSSDSGIFGNRYRLAFNGRERG RGPELPQHMLRIIDQVEQCNSKENSAASTGI-----KRSPSSRGIFGNRYRLAFNKRELC LSPTLPRHIIRVLEEAEAEATTSSVAQRMEL----LKRSQSNLGIFGHKYRLAFNKRERC ASPQIPANLLKLVEQGNNREPKKRLSKISHPRSNSYSNSPSFSGDHSARSNESRNNSELT SPPSIPLHLLQTLEEVQADNKEAAFGAGYGV---PLMKTQSDLGIFGNRYRLAFNKTERA ASPQIPANLLKLAEMRKNPRKESIDSNRNNSLNNDMIQYAS-RGSYERRYSVKRLREENY ASPQIPANLLKLVEQGSNREPKRRLNKISYQRNNSYSNSPSFSGDHSARSNESRNNSELT ASPQIPENLLKFVEQRRNSIDNDSENSTSGIVNTGSHGSASVVGSTNSQDYLKRKESKPV ASPQIPANLLKLVEQGNSNNNSRDQRRSSFHRTNSFHNSPSMSGEHNSNHNPILRRRTLV ASPQIPANLLKLVEQRKESPSMSPEARQSSIDSTQSFAASRRKSSVDSRYIFRLDRNEKH ASPQIPANLLKLVEQRKDKRDIDSDNSRHGSFNNNEIYLTAARMNLERRRSIKRGKDYKY ASPQIPTNLLKLVESRKTSRDSEPDVSRNNSFTSDMIFSATRSNFERRRSSESLKEFQKY EAPKVPERILKLIGEAE--AQNNTIISQDEI---DTKNQDRNHGIFGNQYRLVFNKKERG LGPSSPEFMRSRMYSVTMSNMNSNPV---------------------------------- QYEYYKSQDGNDDIETVCLKIPKENDLPGWFKFQRDLWEQENIPQIHHFYKEIYI----- EYTYYQASNVKNAFS---IGVPTEEALPNWFKFQRDIWDQQHAVEEHNHYKEIFI----- DYDYYKV-RAKDSVK---IRIPSDSELPDWFKSQRDLWEKENVPEEHHFYREIFT----- DFRFYKNDDSKYAVT---ITIPKEPNLPEWFKFQRDLWEQEHSPEEHHFYKEIFM----- DYGYYKA-RGKDNVK---IRIPCDSELPDWFRFQRDLWEKENVPEEHHFYREIFT----- EYGYYKA-GGKDNVK---IRIPGDPQLPDWFKFQRDLWEKENVPEEHHFYREIFT----- ------------------------------------------------------------ DYGYYKA-RGKDDVK---IRIPSDPELPDWFKFQRDLWEKENVPEEHHFYREIFT----- FYKYYNN-------------------------FXQDGMEDALTLQ--------------- EYEYYRS-GSTNAVH---IKIPRESLLPQWFKFQRDLWEQLNTKQTYNFYTEIFM----- DYEYYKS-RGQNSLE---LNIPGESFLPTWFKFQRDLWEQENTEEEHNFYKEIFV----- DFMYYKNPKTFEHVHVLKIKLPAEYKLPDWFIVCRNAWEREFQRLNSEEKY----MTNEV DYEFYKA-GEHNILT---LNIPKESLLPHWFVRQRDLWENENAQEEHNFYKEIFI----- DYKFYKKPISFENVSIIKLKLPPDNKLPDWFIKNRDCWEENFRILNKV------------ DFMYYKNPKTFEHVHVLKIKLPAEYKLPDWFIVCRNAWEREFQRLNSEEKY--------- EYKYYKNPKKFENVGTIKLKLPAEHRLPNWFTKSRDIWEKNYRLMNEAGGL----RNYSP DFKYYHNPKTFQNVSVLKIKLPAEYKLPEWFIAGRNLWEREYQRLNS--------PTTST EYKYYKAATSFKDVEVIRLNLLPEHMLPEWFIRARDFWEQTYGNKRV------------- DYKYYKNPTTFENVSVVKLKLPADNKLPKWFIRGRDFWEGHYKTTNGIE----------- GFYYYKSPYTFEEVNAIKIKLPQDTKLPAWFRSQRDYWEANFRKLNGLIE---------- EYEFYENHKDSLVV----IKIPIEPKLPEWFKFQRDLWEEKNVKQDNIFYAEIYS----- --------------QTVIIKVPDEEVLPEWFKFQRDMWLEEQADRDKIEF-----ESDDG ------------------------------------------MIGGKSSPKSMKNSIGST --------------------------------MSTDMAFRTRSQGSTGSSGSLKRSVKKF -----------------------------------------MASTSKYPKKNIKYTLTHT ----------------------------------MGSIAVKHQETPASPKKSVKTALSHT ----------------------------------------MTVSTSKTPKKNIKYTLTHT ----------------------------------------MAISTSKHPKKNIKHTLAHT ----------------------------------------MAVSTSKTSKKNIKYTLTHT ----------------------------------------MAASTSKTPKKNIKNTLTHT ------------------------------------------------------------ ---------------------------MSGDRGADAPYSVADSRRKSRARPGLRSSVSSW ----------------------------------MLATTRPRKKSSISSSTGIGSSIRTI QSVNNFPISTKSKQELLRKSKSTPRLRGISSPVTSSSTLPTSTPTTNAKKKQKRKQTTNF ---------------------------------------MVPRGHKTSSGSPLGGSIRNF ----------MIDTIETSTENSSFQPKSILKNSKSVLTLQSKTTPSDRKNSNSKKKVSSF ------------------------------------------------------------ SPSNQFVIPSSKKKKIAGADPEHLSTKHKLALAQTHTHTQTQTNTNTNTNTNTKKSSIGF PTTTTTATVTTTTITAANKEHLLRKAKSTPKLRSSTTTTTKSISTTKKSKKQSSSGISSL ---------------------MEPSSFNETTPTSTQPGLRKARSTSTLRKRPKRISL--L ------MVVIHNLYTCNEPSSSTTTQHGHIPILRNAVSLPDIRSRAKKKSSPLKKEISNF ------------------------------MPEQDISHSPQRSKDQSRTKKNRRSKVNTL ---------------------------------MAKAELKNKKSISIFHGKGVKSSISQT HVVVRKKTKPRRKTQTPTPQATTVAPMDLDKEVVLTAEPVVSPSDSSTNKVPTKGRLKRY LRKWRSTLRKVTHDTLNSLDEVTANEEKIDALFDGEGGKTVNWGPVRTSKNVTNDLKSSS MGKLMRTVKHVAHETLDDSD-TDYDYGTVDNMFI-------------------GPVTAEN LQKWKETLKKITHETLSSIDDSSGSDEKIEALFT-----------------VAQPPVTAS LHKWKTVLRKITHDTLTTLDDSSSSDEKIEALFDGVEETSPLKHGGEGPIHIVTNPISKL LQKWKETLKKITHETLSSIDDSSGSDEKIEALFT-----------------VSQPAVVAS LQKWKETLKKITHETLSSIDDSSGSDEKIEALFT-----------------VPQPAVATS LQKWKETLKKITHETLSGIDDSSGSDEKIEALFT-----------------VAQPVVETS LQKWKETLKKITHETLSSIDDSSGSDEKIEALFT-----------------VSQPAVVAS ------------------------------------------------------------ MHKFRANLCKVTSEALAETSGSDSGRSTVDALFD------------------GATETADG LHKCKTNLKKVAHEALGDSS-SDGESTTVDALFDGDT--------------VKEESCLPQ FRKISTEWNSFVSKLKSISDDVLTTDDIAEEFFIEEDSDDTGFDR------LMRSHRGYT FLKCKVGLHRISKEALDSE--SSEEHSVVNSMFE---------------------SEARK IKNISILWNLLRLKVRSLSDEVFTTDELVDDLFVDTDLDDPLER-------LARNNKGYA ------------------------------------------------------------ FKRISNEWNSFLHRLKSVSEETFNDEHIVDDLFTESDLDDLSTLDK-----LIRSSKGYN FRKFSNFLSKISDDVLNHPDDNFNNNSTIDERFLQDYKKFKSLDLLAEHYKNTPPKQITS VKRFVTECNSILTKLKSLSDTVLTEDEDVADLFQVTDAEFFL---------HKQGSGGLT FKKISIEWNLLLFKLRSILEEVFNTDELVDDLFVDVENDDTLDR-------LIKSNKGYN LKRATSEWGNFWARIRSLSEVVFAPDGSFDELFETSDSEGAFER-------LTKVSKAYT FSRWRSTFKKITQETLNSLDNGSMNDDKVEALFQ------------------ADDSSVST FSRQFSELKKVSSTTLDNVDEPTQPSGSVGDLHLHLPPLATKEEQGSAAPLVDPSKKPKQ FGFEKSTTAGLLKSGVGGVGGT-SMRLSEESEEGGSTTGTSNKHEQLTIM---------- NKADCNRPQNLQNDA------IHENRLSSNSETLAFRSETDGYSADT------------- KGIERDSGASMSQVGMGGVNSTLEMKLTDDSEESSSANNATATTTTS------------- RSIDRDSGGSLSPPVEGG-PSELGIKLNNDGRSEGDITTTTKYS---TTSDEGRMTD--- KGIDRDSGASMSQVG-GGVNSTLEMKLTDESEESSSANNTTTTAS--------------- KGIDRDSGASMTQAG-GGVNSTLEMKLTDESEESSSANNATTTTS--------------- KGIDRDSGASMSQVG-GGLNSTLEMKLTDESEESSSANNTTTTAM--------------- KGTDRDSGASMSQVG-GGVNSTLEMKLTDESEESSSANNTTTTAS--------------- ----RRSGESITLAG-----TSTDMRVTTETEDDGTDETKVSK----------------- RELEGDTEA----------RSSTSQTLVAKSEEEAALGKHSQSWT--------------- KSVQRISEDGNSSTS---ATQTGEMRLTDENESGDTISLEEEA----------------- STEEKFLQEYKKYKSLDTMAAAYQKNQHNKNNNNNNSSDPTNMSSNFTGSSNKVHYTLQD KGLKESISEERNSST--SVPLTREMRLTDEEENEDLDTESIQD----------------- STEEQFLKEFKKHKSLDKMHEDYVQKVQPIHEELKSSTTATSDIQTKGSLSLQDLIRQIS ------------------------------------------------------------ STEEKFLQDYKKFKSLDNMYAHYNNNNNNNNNNNNNTGSSTTIGSDQTNLKLRHTLQDVI TGTNTANDVTMTSTLQDFMRKQSNQEILPTSDEFLSDDIIQAD----------------- KAERQFLSDYKNHKSLDAIVMHYQKIESAETNSSVEDSGKMT------------------ SASEAFLEGYKKYKS---LDRMAAIHLKNEEVKSSTTFVSDSNHNKMSCTLQDFIQQSAG SAEEAFLQEYRKHKSLEKMYEHHQQG-NDEIRSSTTMGSESPVGQDVGLSISKR------ SDPNSEGTSYASNSMPPNLGAAVEMRLTDETESFECSDSS-------------------- KATQASSPDQMGDKGPSAARDMASLGFSAHSSPSKTPAKKLSSSTPTSAAPSSLNQTNKS --------------------KSSSGGSQGVSHKEKLT----------YDNFDAVAECNKL --------------------SEAAN-----CDECIQD----------FESFDPVEECAKL --------------------HTLSN-----SRKSTQN----------FENFNVVEERIKL --------------------HHNAS-----STAQLQNIKNKVILEETYANFDSVKECAKL --------------------HTLSN-----SKKSTQN----------FENYNVVEERIKL --------------------HTLSN-----SKKSIQN----------FENYNAVEERIKL --------------------HTSSN-----SRKSTQN----------FENYNVVDERIKL --------------------HTLSN-----SKKSVQN----------FENYNVVEERIKL --------------------QTTAK-----EERERIP----------FEDCDTVDECAKL -----------------------------------------------FETFDPHEQRQVL --------------------DTQGK------TNAVQT----------FANYNPVEECTRL IMRQQQSQSQQQQPQRPFSEPLLPNGEEFEILDEDDEDGESTAAEIVYNDIDMIELRKEF --------------------SQQCR-----STSTKQT----------YATYDAVQECAKL --------------------DTTNSSKTPCNDSEDDEEEEGGSKLVSYHDVDICKMREDL ------------------------------------------------------------ RQQASNYQFQNIDEIDLDEEASAAAAAAATTTSSSASASLSNTQEIIYHDIDFALLRKEF --------------------DEDDE-----DNESTSGKVL-------FHDIDIIELRKEF -----------------------------------------------YKDLDVTRLRQKM NSNVNLDMNSRSPHPDIPIELDVDSDREDGMDDESEEEGEGYLNEINFRDLDLCKLKQEF --------------------VGSDNQEAGSTAVESTN----------YDELDVCKLREQM --------------------SDEDD-----SDSNIET----------FSNYNATEKCKEL PKSTMQRLEEKFASWFSSKKSSSNENPKKPKKKRVDFVLVHKQVESLFHDKKPAPLKARL R-----QRS--DKP-------FVGGPKIWEKRRKLWCEPSVSAEEIAHRRENGRGVFDAI R-----QRQPDGVP-------FIKGPEIWEKRRQLWLKV--TPENTLAHSEKSRAMFSDI A-----QQS--KKP-------FCDGEKLWRRRRQFWTQHTEQDGSIGDDGATHREVFQAI R-----SSK--EEP-------FIDGDLIWKKRRDLWNKP--TKDIDPAELKRRRDVFKSI A-----QKS--KAP-------FCNAEKIWKRRRQLWTQPTEQSESANNDGVTRREIFQAI A-----QKS--RTP-------FCNAEKIWKRRRQLWTQPTEQDGSINNDGATRREIFQAI A-----QKS--KAP-------FCSAEKIWKRRRQLWTQPTDQEGSVNGDGATRREIFRAI A-----QIS--KAP-------FCNAEKIWKRRRQLWTQPTEQSESANNDGATRREIFQAI R-----RET--GEP-------FCQGDXIWLRRRESWTQP--AKSNSINESIKRSRKFTTI H-----GDS--SVP-------FVDGPKLWHIRRELWTAP--TANNSVQEAAEHRASFRKI R-----SEF--GEP-------FTQGELIWRRRRELWTTR-PSNSTKCNESQQHRSSFDKV EMWVNNKNTSDTDSKSTLFSQSNIGTTLWEYRRNKWLIC---NDPEKTETRLKETSITHI R-----AAS--EEP-------FSGADQIWKRRRDLWTKS--TSQADLQTAQRNRDRFNEI SLLLKQDTS--KSTLRERGSQINLGEMLWEYRRSKWLIT-NPEGELRAEEHLRQLSIAHI ------------------------------------------------------------ EAMLASTNSATRVPQQQLNNSINVGSTLWDYRRQKWLQP--KYSTKRIKERIAKSSISHI ETWVNSKSTTDTDSKSTLLSQSNIGSNLWEYRRSKWLQC---DDPNKLNNRLKQTSISYI ETKDNSTES-SQEPDDLKNQNV--GEFLWDYRRTLWLEHDKDSVEEKLQNSDTHVAMENI E-----IHAKNESP-------AMDGTSLWEYRRSKWLA---NDDPQKVEKRLRKLSISHI E-----QDK--QEP---LSSGDCLGEKLWKYRRNIWLTP--TKSEEDIEDHIVEQSLSHL R-----HEL--GEP-------FCSADIIWKRRRELWTEI-NETNNDISGSEKRKQTFEKI R-----ENEITPAPDSGADRSWNEGYRLWKERRAAWLTPKEEGGNNAEAESSDTVRFEDI PEAYHTSVYKKLVVDNKPLKEP--LNLSHAMKVINAGWIDTKKWANAGKGLPTAKLIIPL SPKKYGPIYKRLVMEDAHLRKN--LNLQDVIKVIDAGWVETSKWDRAAQGAAMSTLLLPL PEEYYARIYKKLVVDDKPLREP--LNLEDALQVINTGWTETKKWANAAKGMPMSCLVLPL PEPYYPRVYKKLVVDDKPLREP--LNLEDALKVINSGWTETRKWANAANGLPQPTLLLPL PQEYYARVYKKLVVDDKPLREP--LNLEDALQVINAGWTETRKWANAAKACHMSCLVLPL PQEYYARVYKKLVVDDKPLREP--LNLEDALQVINAGWTETKKWANAAKGMPMSYLILPL PEGYYARVYKKLVVDDKPLREP--LNLEDALQVINAGWTETRKWANAAKGMPMSCLVLPL PQEYYARVYKKLVVDDKPLREP--LNLEDALQVINAGWTETRKWANAAKGMPMSCLVLPL PRQCYVKIYKXLSIDDKPLKEP--LNLKDALKVIDAGWTEIRRCEEAANGVV-------- KPHYYPRIYRKLVLDDRPLSQP--INLEDVMKIMDAGWLETNKWERASRGLAMATLVLPL SPQYYTRIYKKLVLDNKPLRQP--LNLQDAMRVINAGWVETNKWERASKGLAMSSLIIPL PKESYAKIYNNLIEKNKTLKHNKHINLSDLVKIINAGWIAEEKWDRAARGLPHSTLIIPS SPRHYVRIYHRLVVDGMALKHP--VNLQDAMKVINSGWVETQKWERAANGLAMSKLLLPL PKNSYVRIYNNLVDKGRLLKDDKRINLSDLIKVINAGWIAEERWDRAAKGLADSTLIIPS ----------------------------------------------------HSTLIIPS PKESFPKIYENLVDKNKALKSNKKLNLADLIKIINAGWIAEERWERAARGLAKSKLIIPT PKDSYVQIYSSLIDKNKTLKNDKHINLSDLLKIINAGWIAEDKWERAARGLPGSTLIIPS PPSSYSKIYMNFIEKSKPLKDGKRFKLKDLIDIINAGWVHDQRWERAAKGLAGSSLIIPA PRDLYVKIYNNLVDKGRLLKNEKRINLEDLVKIINAGWIAEEKWERAARGLPHSTLVIPA PREALPKVYTNLVDRGRVLRQDRYVNLEDLTKIINAGWIAEEKWERAAKGLPGSTIIVPS PADYYPRVYKKLVIDDKPLKDP--LNLEDAIQVINSGWTETKKWATAANGLGMTVLVIPL PEEGYPMVYERLVDKTKTLKKP--LNLAFVLKVMKAGWVATGQWPNS------MNLIIPS IGTGNVPQLSIDLLLHSTSFNYVKRIDSKFCYPFSGPLDHAEDPKTLFSSAIELFKQKDE VSTGNVSQLCVDLVLHSEEFTFVKELDSIWLHSFIGPLDFVSSKPKQFTTPLELFYNRRL VSVGNIPQLSVDWLLNSQEWEFVEALDSKYLVEFVGPLDRPGGDSMKYSSALEVFYNKKR VSTGNVPQLTIDLMLHSLEFQFIRALDGVFLHPFLGPLDHSDKPISKFSTALELFYNEEK VSVGNIPQLSIDWLLNSQEWEYLEALDSKYLVEFVGPLDRPGSDSMKYSSALEVFYNKKR VSVGNIPQLSVDWLLNSQEWEYLEALDSKYLVEFVGPLDRPGSKSMKYSSALEVFYNKKR VSVGNIPQLSVDWLLNSQEWEYLEALDSKYLVEFVGPLDRPGSASMKYSSALEVFYNKKR VSVGNIPQLSIDWLLNSQEWEYLEALDSKYLVEFVGPLDRPGSDSMKYSSALEVFYNKKR ------------------------------------------------------------ VSAGNVPQLCADVLLHSTEFRFVRELDGQWLHPFVGPLDYVQESLKRVTTPLELFYCEQR VSAGNVAQLTTDLILHSLEFDYVCDLDSTYLHPFVGPLDYVVSASKKHSTPLELYHNPKK VSIGNVPQLAIDLLIHTHNLEKVDSLDDLYLYPFASPVDYVTEPKKGISHAAEVFHNKDL VATGNVPQLMTDLILHSLDFEFVRELDSMYLFAFTGPLDFVSKSSKTLTTPLELFYSKKF ISIGNIPQLANDLLIHTLNFNKIGSLTDTYLYPFASPIDTLVGQKKGISTAVEVYHNKNL ISIGNVPQFAVDLLIYTHKLRLVDSLDDLYLYPFASPIDYVTKRELGISHAAEVYHNKDL ISIGNIPQLTIDLLIHTYNFNKIGILNDTFLYPFASPIDYSSEPKEGISHAIEIYHNNEL ISIGNIPQLSIDLLIHTLNFIKIGTLDDVYLYPFASPIDYCKTSKKGISHSIEIFYNEEL VTIGNIPQLATDLLLHNLGFAKVAALPDHFLYPYVSGIDHLEKLPRGISLALEVFYSEKY ISIGNIPQFTVDLLIHTFDFVKIGTLDDSFLYPFASPEDHAKPVAHGVSNAIEVYYSDKL ISMANVPQLAVDLLIHTLKLEKVGSLDDKYLYPFSAPFDRMENPKLGISSAVEIYYSKEL VSTGNVPQLSTDLILHTLEFQFVQAVDSTFVHPFVGPLDYVDDPEKQYSTGLELFHNESK VSCGNIPQLTVDLLIHSLDFSLVSRLDDSYLHPFASPVDHVQVESGHVATAIELYRSEKL QIYVIQQRTPIIPGYLNNFIVETLIPVLHEYQITELIVLDSFGALDGVVNVGTCNLSSVN DLYVIQQRSPVIAGYENQFFKEVIIPLIKSYGIESVIVLDSAGALDPSVATAKCQLESLD DIYAIQQRTPLVSVYLNNFIVEVILPLLSKYNVQEICIWDSLSAMEDEHSLGEVQIDDVS NFYIIQQRTPIIQGYMNNFIKETILPLIMEFKIENVIVLDSFGVLDELNSLGSCNINSIN GLFAIQQRTPLVSVYLNNFIVEIILPFLSKYNISEICIWDSLYAMEDENSLGEFYFDDEA GIYAIQQRTPLVSGYLNNFIVEVIVPLLSKYNVSELCIWDSLSAMEDENSLGEFHFDDEA GIYAIQQRTPLVSVYLNNFIVEIILPFLSKYKISEISIWDSLSAMEDENSLGEFYFDDGV GIYAIQQRTPLVSVYLNNFIVEIILPFLSKYNISEICIWDSLCAMEDENSLGEFYFDDEA ------------------------------------------------------------ QLYLVQQRSPVVQGYENEFCKEVLLPLLEELAPQRVVVLDSVGEFETEVSVATCNVTSIS QLYVLQQRTPIIQGYENNFCHEVLVPLVQKLSVEKVLILDSISIFDSLISIGTCELSSIS NLTLIQQRSPILPYNTKLYVTNIIIPFITSHEFDRILILDSSDALVEHISSGGIELYTKE DLYIVQQRSPVLQPYDNNFCKQVLLPLIEETKITTLIVADAFEDYEELISLGVCDISQVD KLTIIQQRSPIIPSFTKTYVNEVILPFIKEAKVKRFLILDSSDALVENLSPGTIDFYSNE NLTLIQQRAPIIPNHTELYVSKIIIPFIKSNEFDRILILDSLDALVEHVSSGDIELYTKE NLVVVQQRSPIIPSYTSLFVQNVINPFIKHSGIQKVVLLNSQDLLVKGLENGHVEVFSLA NLTLIQQRSPILPSYITSYVSEIIIPFIKFFTFKKIVILDSSDALFEHVNAGDIEIYNSE KVTLLQQRSPIIAGMSKQHIQQILLPFIAEASFTKIMVLASADALEEK--RATMRLFSDS NKTVIQQRSPIIPSFIATHVNDIILPFVVKSGFDKVVILDSSDALVEHITPGSIQVYTNE QVTAIQQRSPILPGFTEHYVNETIAPFLSQHKFRNVWILDSVDAMSEGLPSGTMKVFSNS DLYVLQQRSPVIQGYLNNFIKRSIVPLLNKYGIDEVVIVDSYGALDEDVSLGVIDLNSIG DTDVIQIRSPPIADFKQAFSAQ-LEELTKKY--TNVIVLGSSDALREQVGAPKIEYYTSD DLIQHLNLNFDDKGIQQDITTEQDIFKVVYHLTTSNLQLNKIKYYSTFVHEGDNSEDAYT NITLRLSIHFDTASFQQNFSADQPVFKLFHHLLQSDLNLKSITYLSKVVHEGDNSWDAFQ DLLSTLRLQFTPTSFQDKIAIDQQIYKILFHILQRPQTLRSIKYCSCLANEGDNSLDSQQ ELTRSLNVKFTGDSVQQEISPKQDIFKFAYHLITTGSTLNEIKYLTCFVHEGDNSMDAKM ELLSNLHLHFTPTSFQDKISVDQPIFKILFQILQRPKALRSIKYCSCLANEGDNSLDSQQ DLLSKLHLRFTPASFQDKISIDQPIFKILFQILQRCCTLHSIKYCNCLANEGDNSLDSQQ DLLSSLHLQFTPTSFQDKISIDQPIFKILFQILQRPQALRSIKYCSCLANEGDNSLDSQQ DLLSNLHLHFTPASFQDKISVDQPIFKILFQILQRPQALRSIKYCSCLANEGDNSLDSQK ------------------------------------------------------------ DVAKGLQLSFRQGSFQRGISTEQFIFKFSYHLLARSADFAELSYVSIFIHEGDNNEDALL DVTRRLQLKFTDSSIQDGISAEQLVFKLCYHLLSAPSKLREIKYFSIFVHEGDNSQDALL DLLSSMKLKEESTTAAHEDNRNSKYVRCLLENFSNEFKDVVIDLLVSYVYEGDNFYDGEN NLAGKLQLKFTDSSFQSAISTEQLIFKLCYHLFKLTHSLKEIRYFNTYVQEGDNSEDAAA DLLNTLNIQVDAMQLGKG-NDHSSYIRSLITYLGDLSSDFEVNVLVSYVYEGDNFYDGEH DLLSSMKLKEKSTTNEHEDNRNSKYVRCLLDSFGNEFKDVAISLLVSYVYEGDNLYDGEN DLMNELKLNNTSNDANIDDDESFAFVKSIFQAFESTLKGLDLTVLVSYAYESDNFHDAET SLLSSLKL--NEKLLDEQIDQHSNYVKYLLQELNNELNDIDVNVLVSFVYEGDNFYDGEK AI-EWMQISLDSLPKDLDKYTEELISKIQPELEGTKKPSIAASVLVSYVYEGDNTQDAFS DLLNSLKLKYLDISLQETPYEHSSYVRALIAALSPAHSHAEVNVLVTYVYEGDNFADSEI EMLRSLNILPDPTNVCHSLYACKLVAKLI----SPGARNFELGTIVTYIYEGDNFNEAEK DMSRSLNLTFTEQSLQQEISTRQEVFKFVYHLLSQLNSLKTIKYCSLFVHEGDNSYDASV --LATLSL--------PAVLPGSGYFRSLVK--GPALG------LVFFAYEGDNFGDAHQ FYNNLMLAQPPRIDEFHPPVSWKGVYGFTPIRSAYDELYTRRLHISPVLLKKGKGGPVED ICEKLAELIQIQ-GRLTAPVSWKGVYGARPIASGFDQIYSRPFSSYAALLAKKTSGADNE FLQWIISQRAPTISKFVRPISWQGVYGAADSRDNFIDLYSRPFSQSFTILKKKSSTPTEK FTEWILRLLNESPIHLKTPISWKGVYGFNSIPDSFDEIYIRQFTIYSSLLKKRVPL-EKA FLQWIISQKVPPIVKFVRPISWQGAYGMADARDKFVDLYNRSFSQSFIILKKKSSTPTEK FLQWIISQRVPTIKKFVRPLSWKGVYGVADTRDKFKDLYSRSFSQSFIVLKKKTSPPIEK FLQWIISQKIPPITKFIRPISWQGVYGVADSRDKFINLYSRSFSQSLSILKKKGSIPAER FLQWIISQKTPPIAKFIRPISWQGAYGMPDSRDKFVDLYNRSFSQSFTTLKKKSSTPAEK ------------------------------------------------------------ LCTELPTFVEPRLETLRTPISWKGVYGSRRIPDGYDELYIRLFSSAGVQFAKRGQAAKEA VCEQLPVILPGKIVRYATPVSWKGVYGMRPIPSSFEDLYIRQISYSYPLWKKKQAKSEDN LANKVNSVLSPAVQKWVRPVSWAGVYGDKPVPNAMEQLYGNSFHSSSQCLAKKKSSDSSE ACDQIPNVIPPRISKYQVPVSWNGVYGVRNAPTDFEELYIRMFSTSIPVLKKKASKGEDE LANKTIEALGSPVKNWIRPRSWLGVYGDRQVPNAMEELFGRNFQISPILAKKKGGNEIEE LANKVNSVLLPKVEKWVRPISWSGVYGSKPVPNAMEQLYGKSFHSSSPCLAKKSSNDFSE MMQQLKEELNPKFKDFIKPVSWRGAYGDRAVPNAMEGIFGATFHTTSFLQGRKLNKVEHE LAFKLSDFLNKKIDHWVRPVSWFGAYGDKPIPNAMEELFGSNFHSTSINLAKKKNSEDVN MASAAAKVFGIGSAEWKIPVSWMGVYGDRPIPVALEELYGRSFHASFVSLKKKKGSAKDV LANKLLNVLEDHIKNWTRPISWYGAYGDKPVPSAMEELFG--FHSSGFQLAKKTSKEEPV LSDKVAEICEWKIESWKRPVSWSGVYGDREVPTAMEELYGRAFGTTTSLLAKKNSKKEDD LCEYLPQAIDNKLENLQAPVSWKGVYGQNPIRTAFDEIYMRQFSITSSLLKKRKGSGQVD LADAVIRLLGGSEMKWTQPVSWQGAYG-HDAPLGVEQVYCVLFSSTPVTLGKKGGKAAAE EEIDIVNPSIYVDELVSKFDKSLELYSKELTDKRKGSVNANIFDNLSLKNGALFKEMAST EPIEIIDVKKYVIDATKQFEKTLELHKRKLAEQKVGTASPTIFNDLRVKEGQKFTELAAT VEEDEVDVNELLRKAEAQFKKTLETQKQKLNEMKQGNFNPKVFDGLMF-KNKKFTDIATT SDTEIVDASKYLKEATKQFATTLELHQKRLNETKQGTSNSKVFDNLIISDGKKFTDMATT VEEDEIDVNELLKKAETQFKKTLEIQKQKMNEIKQGNFNPKVFNSLVFKNNRKFTDIATT VEEDEVDVNQLLKKAEAQFKKTLETQKQKLNEIKQGNFNPKVFNSLMFKNNKNFTDMATT VEEDEVDVNDLLKKAEAQFKKTLETQKQKLNEIKQGNFNPKVFNSLTFRNNRKFTDIATT VEEDEVDVNELLKKAEAQFKRTLETQKQKLNEIKQGNFNPKVFNSLVFKNNRKFTDIATT ------------------------------------------------------------ VEVDLVDVGDYVKKATERFQHTVELHKKRLGQMKAGKPDATMFDGLAVNEKQKFTELAAT EEVVVIDVKKYIEQATNGFRTTLELHKKKLNEAKLGTANPQIFNGLKIKEGHKFTDLATT KADENAEVTIDFQKVTSNFDNVLSKFNKAATDIKLGKLNPKIFDNLEVEELVPFTSVAQT EVTEVIDVKQYIQRATEKFNTTLELHKKRLNDFKLGAANASVFDALKVKDNVKFTDLATT DNTDNQVPEIDFDDATNKFKGVIERFSKQANEAKLGKTSPNIFDKLIVNGEVGFTSVAQT KVDEIPEVTIDFQKVTSNFDNVLAKFNKAATDIKLGKLNPKIFDNLEVEELVPFTSVAQT AQTEAVTPTIDFKDAEERFQHVLEKFEKAANEIKLGRLNPRVFDNLMVSEEVPFTSVALT EDIEEQEVTIDFDHVTKNFETVLSKFNKAATDIKLGKLNPKIFDNLEVEELVPFTSVAQT EEEVTDAPQIDMDEVTKRLQSVIDKFAKHANEAKLGKTNPQIFDHLQVDGEAVFTSVAQT EEDDAEAANIDFEDATVKFQSVIEKFNKAASEAKLGKTNPKIFDKLSVDGELPFTSVAQT AEEAGETPEIDFDDAKRKMNEVIEKFSKSANEAKLGRTSPSIFDHLSVFGPQPFTSVAQT EEVEIIDVKGYIADATKLFDESLELHNKKLNEIKQGRANPKIFDGLKLHNGASFKDVAHT EAVDEDLFMIEWNKFEDLSAKSVAAFAAKAKEIKAGNNSPDLINNIEVDEVYQIKDIASV TLKGKGLLVTVFDPNEVKNIVSAILASGQNLNPERVPTNNQQLKIPLPPPTAESRQNLCK SLKGRNLIVTVFDPKDTKNIVSAIMAAGLNLNPERIPNNDQQLKVSLPPITTETRQAVCK SLKGKNLLITVFDPKDVKTVVSGVLAANLNLTPERIPNNDLQLKVSLPPPTTESRLKVAK SMRGNNLLITVFDPKDTKKIISSILGAGLNLNPERIPNNEQQLKVLLPPVTTESRLNTAK SLKGKNLLITVFDPKDVKTVISGVLAANLNLTPERVPNNDLQLKVSLPPPTTESRLKVAK SLKGKNLLITVYDPKDVKTVISGVLAANLNLTPERIPNNDLQLKVSLPPPTTESRLKVAK SLKGKNLLITVFDPKDVKTVISGVLAANLNLTPERVPNNDLQLKVSLPPPTTESRLKVTK SLKGKNLLITVFDPKDVKTVVSGVLAANLNLTPERVPNNDLQLKVSLPPPTTESRLKVAK ------------------------------------------------------------ SVKGKNLIVTVFDPKDTKRVASAIVGAGLNVTTERVLENQQQLKISLPPVTTETRERLCR SLRGRNLLVTVFDPKDTKNIISGIMAAGLNLNPEKIPNNEQQLKVSLPPPTTESRKQMCK SVKGRNFIINLFDAGYGKHVINSIIGSGLNMSGTIDPTNKFQIKVPIPNITTETKQENIK SLKGRNLIVTVFDPKDTKLVISSILGAGLNLNPERIANNDQQLKIALPPPTTETRKQTCK TVKGRNFMITVFDPSNVKSIINAVLGSDLNMNPQIDPSNKQTLKVPLPPLTTESKKENAK SVKGRNFIINLFDASYGKHVINSIIGSGLNMSGTIDPTNKFQIKVPIPNITAETKQENIK SMKGRNFIVTMFDPLQSAAIINAIIGSGLNMSGTTDPNNKFNLRIPMPPVTQETKQNDLK SVKGRNFIINLFDASYGKHVINSIIGSGLNMSGTVDPTNKFQVKVPIPTITSETKQENAK ALKGRNFIITVFDPANTKHVVNAVLASDLNMNPIADPSNKQMLKVPLPPVTTESKKENVK SVKGRNFIITLFDPENSKHVINTILGSGLNMNAQVDPSNKFTLKVPLPPVTTETKNESVK SIKGRNFLITVFDTANSQSIINAVLGSNLNMNPQVDPSNKSALKVPLPPLTVESKKESAK SLRGKNLLITVYDPKDAKNVISAIMGAGLNLNPEKDPNNSQLLKVLLPPPTTESRMNLVK ALKGGRLSISVYDPSHTKQVTASILASDLNMNPQPQANSPQILNIPLPPPSAESRAEQQK ELKTVFEKYKQPSKNSRNEVMKKLKSLQKDESVKKIIQNVEKVHKDYVTKLSEQLKQAEK DLKKVFEDYKHALKESRGEIMKELKHLQKNDDVKKVIQDVEKIHKEYTIKLQEQLKQAEK DLKKVFEDYKQSLKESRGSILKEFKAFKKDDSVRKAERDLEKLHKDYVNELHKQFLQVEK LLKGVFEEYKNSLKVSRNQILKEVKSLKKDDSVRKVITDIEKEHQNYVKKLEEQFKQVEK DLKRVFEEYKQSLKDSRGSILKEFKSFKKDDAVRKAERDLEKLHKDYVNKLHDQFQKVEK DLKRVFEEYKQSLKDSRGHILKEFKSFKKDDAVRKAERDLEKLHKDYVGKLHDQFEQVEK DLKRVFEEYKQSLKDSRGSILKEFKSFKKDDAVRKAERDLEKLHKDYVGKLHDQFQQVEK DGARVFEEYKQSLKDSRGGILKEFKSFKKDDAVRKAERDLEKLHKDYVNKLHDQFQQVEK ------------------------------------------------------------ DMKKVFEEYKNANRHSRSEVLKELKKLDKNDSVRKVIQEIENLHKEYTAMLQEQLKHAEK ELKKVFEEFKNSSKNSRGEVMKELKKIDKNDSVSKIIQDVEKLHKEYTTKLQDQLKQAEK QLKEIFENLKNHKSNSRSEARNKFQSSLKSDSQHQLLKKLETLHKTYVDKLTDAFKQAEK QLKEVFESFKNANKSSRGEILKELKNIDKNDSVKKITQDLEKLHKDYIGKLQDQLKQAEK QLKLVYERFKNRANGSRGDVKNKFQKQHKSDAEEKVFKDFEKLHKQYTDKLTEVFKSAEQ QLKEIFENLKNHKSSSRSEARNKFQSGLKSDNQHQLLKKLETLHKTYVDKLTDAFKQAEK QLKELYEKTKNGARGSRGEVRQKFHGSLKSDSENKQLLQLEKLYKLFADKLQDVHRKFEK QLKEIYESYKNHKTNSRGEVRHKFQSQLKSDAQHQLLKKLENLHKTYLDKLTEAFKTAEK HLKTIYEKYRNKHASTRADVKSKVAKKKKTDAETKVWTEYEKLHKSFTEKLGEVFKTAEA HLKEIFEKFKHAKNNSRSEVRNKFTKQLKTDAENKLLTQFEKLHKQYSDKLNESFKTAES QLKGVYEKFKNSGKLTRAEVRTKFTKKKKSDDEEKMLKDFEKLHKEYVDKLSDSFKSAES ELKIVFESFKSSMRNSRADILKEMKKLDKDDSVRKAMQDLEKLHKDYAKKLQDQLKQAEK ELKALYNAFKAKLTSGRDAFKKDHKKMADKDVVKREDKKFEELQKAWTSKIEKEFKTVSD SVMG-------------------------------------------------------- SVMN-------------------------------------------------------- SVAK-------------------------------------------------------- NVLH-------------------------------------------------------- SIVK-------------------------------------------------------- SVVK-------------------------------------------------------- SVTK-------------------------------------------------------- SVVK-------------------------------------------------------- ------------------------------------------------------------ NAMR-------------------------------------------MTWGGGPMKEDDR SVMG-------------------------------------------------------- SILK------------------------------------------------MDTTDQSS SVLG-------------------------------------------------------M AILK-------------------------------------------------------- SILK------------------------------------------------MDSTDQSS SIMS----------------------------------------------MENESNFDQS SILK-----------------------------------------------MDSYSDQPS AMMK-------------------------------------------------------- SILK-------------------------------------------------------- VILK-------------------------------------------------------- TLMS-------------------------------------------------------- EIAK--------------------------------------------MFRRLTGSQSES ------------MSESAVRGYIN-RKYG---KVLETLVMAE------------------- --MEFGHDAKRVSKRSLLGNYLV-KKYE---NVFASIDNAV------------------- --MSESSTSRRNASKDAVKSYFA-GKYN---KVLDSILEAEAAISRSPNVAEDLTESSAS ------MSSHTSTKKSVVKTYFA-KKYD---KVLDSIQAVE---------------ESIS --MSETSSSRRSASKDAVKSYFA-GKYN---KVLDSILEAEAAISKSPTVAEDLSGSSSS --MSEASSSRKGAGKDAVRSYFA-EKYN---KVLDSILEAEAAISRSPNVAEDLSESSVS ------------------------------------------------------------ --MSETSSSRRSASKDSVKSYFT-GKYN---KVLDSILEAEAAISKSPTVAEDLSESSAS -------KMSAPRKREIMKTYFT-KRYE---KVLDSLMVAD------------------- AKALESVAIGSKKRRSLLGEFLA-RKYE---RIMEAEERVA------------------- ---MDTTNVDAAKAKSLMGSYLT-KKYE---KVLDSLLAGT------------------- DSLQQSPSISSSISSNSYKDFAI-DVLN---KAVVKGNSIA------------------- EKVNDGSGGNRGRRDSIIGEFMA-RKYG---NKRNSALRVE------------------- ------MSEKTGKDNFKYRERAS-KVLS---KMYDKTSDIA------------------- DSLQQSPSISSSISSNSYKDFAI-DVLN---KAVVKGNSIA------------------- RPPSQSLSLSQTLRSGGKRSFY--RNLA---VNLANTAVTK------------------- DILQQSASISSSTSSSSYRDYAV-GKLS---KAVAKGNRIV------------------- ----------MSHENHEHSSRRA-RMMS---SLYSYSSCVA------------------- ------------MSDDKYRLTAT-KVLS---LVYQASSDFA------------------- -----------MEKESYYREKTS-RMLS---KMYDYTNSIA------------------- --------MSEVSEKGLIRHFFT-RRYE---KIVDSLIVNE------------------- SIYGLVNDSQTSMGTMDYANELA-SQLDMLLKKDKPLSTDD------------------- --------EAIAARSNRDE-----LTQRELVQQVMG-----VLVSTSLERLKPGADVVGA -----------PPGDREKL-----LSNKDLVQGIAT-----SLFDATWERFKTMREDDTK GSSEMSHSSLAASSATSQG-----ISKKELLQQIAG-----SLLSTSIERLKTTQSPDSS GTQPSSTTTRSTTAATVTP-----ISSRALLQKVAG-----SLVNASIERIRPERDDTLL GNSEMSHPSLTASSATSQG-----ISKKELLQQIAG-----SLFSTSIERLKTAHSSEVS GNSDMSRPSVTASSSTTQG-----ISKKELLQQIAG-----SLLSTSIERLKTAHSPDGS ------------------------------------------------------------ GNSDMSRPSLTASSATSQG-----ISKKELLQQIAG-----SLFSTSIERLKTAHSPDIS -TTAAVATLVNGDSKRASG-----LPNLEVVHGVAS-----SSFNASSEKLKPNKDKEDL -----------DDEKARPC-----VTNRELVTNIAC-----SLFDATWERLRTGKDQQRK --------NAETKSISSSS-----ISNRELIHGVAT-----SLFDATCERLRASKEVDRR ---------------ESNP-----GSKRAIAISTAS-----TIVEMSLEKYSSSNLSSRR ------------DDGDFKS-----VSNRELIHGVAS-----SFFEAAYQRLKSSKGADAV ---------------GNNS-----GKNKGIAAGTAA-----SLISLGIDRINQGQSVD-- ---------------ESNP-----GSKRAIAISTAS-----TIVEMSLEKYSSSNLSSRR ----------GNNIIQKNP-----GSKRAIAAGTAS-----TILEMGIDRYGNLVDDSSR ---------------ESKP-----GSKRAFAMNTAS-----SLFEKGIERYNLNGNGSRR ---------------DSRP-----GSARGIAAGTAA-----SLLGMGIEHLDRNSEDSLR ---------------DAHQ-----GQNRGAAAGTAA-----ALLSMGIDRVNRTGKSASR ---------------EKHP-----GQNRGVAATTAA-----AMLEVGLERLKDGKVPEN- -------------IEDTAS-----NSNRDLIHTITA-----SLINASIEKYKRDKSASTD -----------SASVASSS-----AASRTSWLGPSIPRHSRHFVDALYDKVILPKLKKSI GDK-------------STYSAAAEEKELDELNEYRRSLSQDRLSKE-------------- TIDDDFQEYINNETDLESNDSFWKDENFRQEYEIRSASSEEEREKPNVKTSLRKQAKDTV SMLE-----YSEDTPYEEQECDDCDGPFKCPVHLGQAAAYYDDEIDAEPAL----EATTS EFSE---------SLTDQFESKVMSSTFSTKSG--------------------------- STPE-----YSVNDSYGEQECRECDGVFKCSAHFEGAPEYYDDETESGPAL----EPMTS DTLE-----ISENDAYEKQECSECDGPFKCSAHFEQLAESYDDEIDPEPAL----EPTTS ------------------------------------------------------------ ATSE-----YSANASYGEQECKECDGSFKCSAHFERAAEYYDDETESGPVL----EPSTS TLE----------KATESSDEFWKDENFKQEIHSESPNSYIETDQDQDQ-----EASKVE TIDDDFDEFALRHELESSADSFWQEETSDNGAGMSDEEDTEEQRAAKLRAVSQVQE---- SIEEDFEQ-YMSNQETQSLDSFWKDENFRQEYENSVVSEEDEKTGNRSSIRSSVVAKES- SG--------------RSGSIDLTDEQISQIESVPSSADDNGDGNKRK------------ TIDDDYEE-FVRSTPSESSDSFWKDDNFRQDYEINSEAGSSQQSANSNVKE--RGSNRQS ----------------ETDGLPYTEDELNQLKELESEMDDSK------------------ SG--------------RSGSIELTDEQISQIESVPTSADDDGDGNKRK------------ SLPS---------SMGRHGSVDLTEEQINHIASMAESADEAKSPKQSN------------ T---------------RSGSYDLTDEQISQIESMADSAEAEKRPK--------------- LTDE------ELDPTLSSGESHGRSKDHRTKEEKE------------------------- S---------------GSLDLDYTDEQLEHIRQMASSAEENELKKH-------------- ----------------STEGVPYTEEELDNLKELASSASEDSKGKRG------------- ASSD---------QGSESSDSFWKDENFKQEYELDTPPSTSLPEGDGSLKGEHQP----- IGDVDSDLGSAVATPTGSGSRRGSFSTIRALDISEEPFSESD------------------ ---DTYFLDMFLDKLIARLIPDNL-----------PEREHFSLVDE---GDEALHGPPFS EETREHFIDMVIDRLILSILPDEL-----------PEREQFSQRVA---EPGRRHSQTVS NTERDPFIDVFLDKLISRLVPEKL-----------PEREHFSSSATIEHDLDTGRVPVFS ---RDHFIDIFLDKLIARITPENL-----------PEREHFVHERT---------AQPVS NSEKDPFIDVFLDKLISRLVPEKL-----------PEREHFSSKTTIEHDLDTGRVPVFS NTEKDPFIDVFLDKLISRLVPEKL-----------PEREHFGSKSTIEHDLDTGRVPVFS ------------------------------------------------------------ NSEKDPFIDVFLDKLISRLVPEKL-----------PEREHFSSKTSIEHDLDTGRVPVFS AKTRQHFIDIFVEKLIAKMVPERL-----------PERERLFQSNS---EDEKLGYQTVS ---QEHFIDILLDKMISAVLPEDL-----------PEREQFTQRVQ---EPGRRRSHPIS ---QDHFVDILLDKMISKLLPDDL-----------PEREQFTQRVN---DPYRRKRQTLS ---SGHFADRMIEKLLKSVLPQDI-----------PEREIFEKRLN---DPERNKRPGLS KKSQEHFIDILLDKMVSTILPNNF-----------PEREHFSQRVN---DPERKKRQKLS ---SSHFVDRFMEKLLKHAIPTDG-----------PEKEMLERRVA---DPERLKKPNLS ---SGHFADRMIEKLLKSVLPQDI-----------PEREIFEKRLN---DPERNKRPGLS ---TQHFADKLIEKLLRSSLPDEV-----------PEKELFEERLN---NPDRVKRPGLS ---SNHFADRMIEKLLKSVLPQDL-----------PERELFEKRLN---DPDRNKRPGLS ---QGHFMDRFMERLLRHTIAEDS-----------AESEQLSSRIN---DPSRSGKPQLS ---RDHFVDKLMDKMLKYTIPDDS-----------PDKAIFEQKIN---DPSRSERPNLS ---SGHFVDKLMERLLKNNIAMDT-----------PDSELLSQRVN---DPDRKNRPGLS ---KEHFLDIFVDKLISKIVPEKL-----------PEREQFSERVL---SPDLKKHQPIS ---ISVFDDSVSVASTASSEPFRISQHN-------PPKPVFDPEAH-------EAGPELS ASVLASNMKKLSGKMDSIFEFQDNMIRVLTWKTPTVTLTALTIFTLICFDLMNVILF-PM VTIMNKNVRALTSRLGAIFELQDILIRLLTWRNPSGTLLALIAFTQICFNPMLLVIL-PI ATVLGGNFKKLSKKMGSIFELQDSIVRLLTWRNPTGTVTSLIIFTLICFNPMYLIIL-PI ITILTKNLKSLTGQMDGIFEVQDSIVRLLTWRNPSGTITMLILFTILCYNPMYLILL-PL ATTLGSNFKKLSKKMGSIFELQDSIVRLLTWRNPTGTVTSLILFTLICFNPMYLVIL-PI ATTLGSNFKKLSKKMGAIFELQDSIIRLLTWRNPTGTVTSLIIFTLICFNPMYLVIL-PI ------------------------------------------------------------ ATTLGSNFKKLSKKMGSIFELQDSIVRLLTWRNPTGTVTSLIIFTLICFNPMYLVIL-PI ATKSTQNLKDLSAKTGGMFETQDTIVRLLTWRNPSGTITMLILLTMICFNPMCFLVF-PL LIIMSRNLKIMTTKLGLIFEFQDSLVRLATWRNPSGTALSLILFSFACFNPMLVIIL-PM ATVLGRNMRILTTKLGSVFEFQDSIIRLLTWRNPSGTVTMLIFFTFICFNPMLLLII-PL FGILTSNVKQMASKMTNFFALQYEVLYIIAWKKPTKTISALVLYTAVCLWPHLVLAY-PL ATILTRNLKVLTTKLGSIFELQDSIIRLLAWRNPSGTITMLVFITMICFNPVYLAII-PV IRILTSNFKRLSSKMSSFFVLQYGLIHIITWRKPTKTLSFLVFYTSICLWPHLILAY-PM LGVLTSNVKQMAGKMTNFFALQYEVLYIIAWKKPTKTISALVLYTAVCLWPHLVLAY-PL FPILISNLKQLGSKMTNLFALQYEIINIVAWRKPNKTLSVLVLYTAACMWPHLILVY-PL VTVLTSNVRQMARKMTNFFAIQYEIIRIISWKQPTKTISVLILYTAACIWPHLVLAY-PL FRIFASNMKQLSAQMGTFFRLQYGLIHVLTWRKPTKTLTCLVVYTAVCCWPHLVVAF-PL IRILLLNFKKLAGKMGMFFELQYGIIHIITWRKPTKTLTALVLYTTICLWPHLVVTY-PL ISVIAGNFKALSGRMTGFFTVQYGLIHIITWRHPSKTLTFLVFYTATCLWPHLVLAY-PL ASTLGRNMGKLGSKMTAMFDMQETVIRLITWRNPSGTVTLLISMTMLFYNPIILLLL-PL IPLLLRNIAELSKRAGGVMKTQTVVLKAIQWQNPCLSISCIFIYTAMCLYPGIVFVL-PG AYIVLVQMTQGYIRRH-PIRRT--------------------------IYIKRRAIGRSL LYLMFGLMIPGYLHRH-PLHRG--------------------------IYLSKRSYGKSL FRFIYGIVVPGYVRRH-PLQRS--------------------------IYPLKRNHGSSL FHVMYGSMARGYMYRH-PLRKT--------------------------IYPARREFGKSL FRFVYGIVVPGYVRKH-PLQRS--------------------------IYPLKRNHGSSL FRFIYGIVVPGYIRKH-PLERS--------------------------IYPLKRNHGSSL ------------------------------------------------------------ FRFIYGIVVPGYVRKH-PLQRS--------------------------IYPLKRNHGSSL LYIMYAMMVPGYMRRH-PLRRT--------------------------LYPIXRANGKSL LYVLFGLMIPGYLHRH-PLRRN--------------------------FYLTKHSYGKSL LYILYGLMVPGYLQRH-PLRRS--------------------------RVLIKKTYGKSL LFVLFGVLIPGFVHRH-PQRNP--------------------------ELIKVKKRGQSL LYVLYGLMIPGYIHRH-PPRRS--------------------------AFLSRRTFGKSL IFLIFGVMLPAYIHRH-PMRTP--------------------------ELIKVKKRGQSI IFVLFSVLIPGYVHRH-PQRNP--------------------------ELIKVKKRGQSL LFVLFGMLLPGYTHRH-PPRRP--------------------------DLIKVKSRGQSL IFVLFGILIPGFVYRH-PMRNP--------------------------DLIKVKKRGQSL LFLLFGVIIPAHLYRH-PFQRP--------------------------EILPVKKRGESF IFLLFGIIVPGYLHRH-PMRTP--------------------------ELIKVKKRGQLL LFLLFGIMIPGYIHRH-PMQTP--------------------------ELIKVRKRGQSL VTLMYMVMIPGYIHRH-PLHRA--------------------------IYPSRTSYGRSL LLFMYGIMAPAYAEKH-PLPKE--------------------------Y--RPSPWTVKN IHDLFHGGKKTN---------------NVLLPSNENDCNGEQENEADLGTSDDCNGTSDE IKSITTGGNTS----------------KLQLRDSIHEFNYEDIDINDLRK---------- LYDVCYEGKNEYTYGQQFF--------SKSFMDTLESRNQEKDEISELDK---------- INTVASGGPSMAQQ-------------PLTTVDTAESLDPSLTEENDEDR---------- LYDVCYEGKNEYSYGQQFF--------SKSFMDTLESRNQEIDEISELDK---------- LYDVCYEGKNEYSYGQQFF--------SKSFMDTLESRNQEIDEISELDK---------- ------------------------------------------------------------ LYDVCYEGKNEYSYGQQFF--------SKSFMDTLESRNQELDEISELDK---------- LRELAIGGIP-------------------------------------------------- LATVATGGKPA----------------SWQSHDDVQEFD--------------------- LDSVASGGKSNTWHGND----------RLREINTTTELD--------------------- LSFLFETPETSIVEDLINEEYLQA---SDEVASSTYSISEETSEVTVSSS---------- IVSIASGGKRT----------------NTPFNDDVQEYE--------------------- LDFFNLSSDTSVIEDLIGKDYHNDSGSESDSLQPVISKSSDTSSMFSKKP------VSAS LSFLFETPETSIVEDLINEEYLRE---SDEMASSTYSISEETSEVTVSSL---------- FKFLNATEETSIVEDLVDTEYLK----EDADIADVNSTSYTMSEAESDNTKASTAVSVSS LSFL-FESPDTSIVEDLINEDYLRE--DAEVASSTYSISEDVSEAAASSS--QMASESDT LDFLNKSDDHSVVLDLLNE--------PKEGFSDTQSINSSSTSVSYAST-----PLTLS FSFLNEGAGEHSIIDDLLSDSVL----GDEGLRPTFSGSEELSDVLQISP---------- LEFLSSSDETSIVDDIVEDRTLRS---AENDLDPVSSRSSDTSSAFTQAP----ISASAL LEDIASSGPSNAWYP------------NNTLVESLNELQ--------------------- EFDMAADDDTSI---------------RAAQIKRIKAAE--------------------- NVVISPAAAKIDKNISTYNLNHGTKVVLTLRDMQNMTTGTVHLMDAIDKFKYGTAAFV-D ----------------ANTVRQSMEFVVNLRDLQNLMSTLVSVIDKMEKFMYGTAGFK-N ------------RPENTQELKHGMKVLINLRDMQDMTSGTLHVIDTINNFLRRASSFQ-N --------NSIDDRKSLNDLSGSTKIIVNLRDLQDMTTGILSFHKSMEKFNLEVAGFK-D ------------RTENTGELKQGMKVLINLRDMQNMTSGTLHVIEAINSFLRKSSSFQ-N ------------RPENTRELKQGMKVLINLRDMQDMTSCTLHVIDAINNFLQKASSFQ-N ------------------------------------------------------------ ------------RPENTGELKQGMKVLINLRDMQNMTSGTLHVIEAVNNFLRKSSSFQ-N ------------------------------------------------------------ ---YNNLHTDTEEWERALHIKQTMEFIVNLRDLQNLMTASVKGIECAEKFVYGDAGFK-N ----------LDDVNKAHNIKQSMEFIINLRDLQNSMSVMVMLSDKLEKFVYGTAGFK-D ---MPTDSESPKKDDVAKHRKSQIALLINLRDFQNLTTDILKGINNAEKFYYETGGFK-D ----YNYEMDPHDIQRAHQIKQSMEFVVNLRDLQNSMSTMVSLSNSLEKFIYGTAGFK-D KLKDGDVNERIQKKDKTRHVKSQMTLFINMRDLQNLTTDVLNGINGAEKFWYETAGFK-D ---MPLDSESPKKDDVAKHRKSQIALLINLRDFQNLTTDILKGINNAEKFYYETGGFK-D QGGTESSEKLDKKKEVSKRRKRNLDLLVNLRDMQNSMTDLLKLIEEGETFYYETAGFK-D SGGGGGGDNSPKK-ETAKHRKSQVALLINLRDFQNLTTDILKGVNEAEKFYYETAGFK-D SASEKTTPEELRKKDKSKYVKSQVSMLMNMRDLQNLTTDILEAMEQAKQLSTNIVGFK-D -SEVISETSVSTDDSKKPIAKSQLALLINMRDLQNLTTDLLNGMDLAEKSWFETFGFK-D STSSSDVNEKVKKDEKARYVKSQMKLLMNMRDLQNLTTDLLQGFDAAEVFWYQTAGFK-D ----SGDSGATSNFSDTNSVSHSMAVVMNLRDVQNITTSLVQVSQATDKFIYGAAGFK-D --------------------KKPVDVKKSMKNFQNATTNLIKALDKLESFLSGPAGFA-N EYKSTSVFFTLLGSVILLVLLSR---------FITW-----SLTISLSAWIGLLSIHPKV EQYSTVVFLSCFVVLFLLWIITP---------FINW-----GLMASLLAWSIMTIIHPRV EGHSTKRFFTGFLSIAVLKILSP---------FVNW-----SYMFSISAWCLLIYMHPRA EYHSTRLFLKLGLIFIILWSLST---------HINW-----GFLMSSLAWSLMIRFHPKL EECSTKRFFTGFLLIVFLKILSP---------FVNW-----SYVCSIFAWCLLIYMHPRA EEHSTKRFFAGFLSIVILKVVSP---------FVNW-----SYLFSISTWCLLIYMHPRA ------------------------------------------------------------ EECSTKRFFVGFLSIVFLKILSP---------FVNW-----SYACSISAWCLLIYMHPRA ------------------------------------------------------------ EHHSTVLFLSGLLVVMGLWIIAP---------YINW-----SLTSAAGAWAALILIHPRV EHHSTALFLTGLVLLSVLWMITS---------FINW-----SLVTSLGAWTAMIAIHPKV ERLSTFIFYGVLLSTFGILFVGK---------YVPW-----RLIFIQGGWTGAILCHPNC EHRSTALFLVGLVTLTISWLVSP---------LINW-----SAVSASAIWSAMLAVHPKI ERLSTFIFYGVIAATSIVLVFGR---------FIPW-----RLIFIQSGWAGLIVCHPNS ERLSTFIFYGVLLSTFGILFVGK---------YVPW-----RLIFIQGGWTGAILCHPNC ERLSTFIFYGVLVATFGAIFFGQ---------FIPW-----RLIFIQSGWIGLTLCHPKV ERLSTFIFYAVLVATFGILFVGQ---------FMPW-----KLIFIQAGWGAGILSHPKC ERLTTFVFYVTIAVTSVVLLLGK---------YIPW-----RAIFIFSGWAGLILCHPNT EHLSTFIFYGVAAATSVVLFLGQ---------FIPW-----RLIFIQSGWAGILLCHPKS ERLSTFMFYGVILATSIILFLGT---------FIPW-----RLIFIQSGWAIVLVCHPRS ERRSTILFFTCFLATGCLWALAP---------YINW-----SFFFSFNTWLILICIHPNI ESLSALIFLLIGFAMIGTFFLSA---------FIPW-----KALQIGAGWGVIIAGHPTL HPYVKSAKNIMKKPKM--------------------------KPENSPQDVAVVMEDNIS RPTVFG------------------------------------LLKKEQLDKGKEALRRTE HPKIIKFF----------------------------------QRGKVEKEYKNLKKKENQ RNKLSKRSN---------------------------------KDETLAEKDLNSHIGLAP HPKIISFF----------------------------------KTGTMGKEYKNLKKREHQ HPKIIAFF----------------------------------KKEGVEKDNKNLERKKIE ------------------------------------------------------------ HPKIIKIF----------------------------------KTGKIGKGYKDLKKKENQ ------------------------------------------------------------ LPMVTAYIND------------------------------------DQLEKGKVVIENVE RPKITK------------------------------------LIKAEQIKKGKEVLEKTE KKFLVDASKARKARAAIEKAKKEEK-----------------SVPEIIIEEADDTVTQFD RPKLAH------------------------------------LIKKEQLERGKEALKRTE KKYIMSIKKSKK------------------------------AKKVKDVKESKEKEGRFE KKFLVEASKARKARAAIEKAKKEEE-----------------SVPEIIIKDANDTITQFD KKFLVDFGAAKKRRSKVIQRNAEAAQ----------------KADPTAETTSNKGLKQLL KKFIVDASKARKQKALLAKLNEKENAAE--------------STPDIVVEDTDGVIKQFD KKYLVGFGNAKS------------------------------SKATEKKEPKQLFLDTFD KTFLVELSNAKKARA---------------------------AKAPQPEEIIESEVKKFE KKYLKALSENKKRKAAA-------------------------KPKKVKEEKDEDGPAVYD REHLLK------------------------------------LMESDKVEEGRKALEKKE LKRIVAILDELEKSD---------------------------DEEKPKESPVIAILQKVQ GEDYNRNI--ILDEPP-------DVKYVEVYEIYKRGL------------------LP-- R----YDI--LLDEPV-------ETRWVEVFEIQMQGI------------------TE-- T----YNM--IFDEKP-------EIKYIEIFEIYKKGL------------------LP-- PI---NSI--ILDEKP-------EVRFIEIFELYQRGV------------------IP-- A----LNM--IFDEQP-------ETKFIEIFEIYKKAL------------------LP-- T----HTM--IFDEKP-------EVKYIEIFEIYRKGL------------------LP-- ------------------------------------------------------------ A----HNL--VFDEEP-------EIKYIEIFEIYRKGL------------------LP-- ------------------------------------------------------------ R----YDI--LLDEKP-------EERYLELFEIYKQRL------------------TS-- R----YDI--ILDEAP-------EVNYVEVFEIYKQGI------------------TP-- R----NDI--IVDDSP-------EARTVEIYELQIKSI------------------LK-- R----YDI--ILDEQP-------EAKYIEVFEIYKQGV------------------VP-- R----HDI--IIDDSA-------EIRIVEVFELQNKNM------------------LN-- R----NDI--IVDDSP-------ETRIVEIYELQIKSI------------------LK-- TQLDRNDI--IVDDSP-------EVRLVEVYELEIKSI------------------LQ-- R----NDI--IVDDSP-------EVRVVEVWELQIKSI------------------LK-- S----RSI--IVDDEP-------EVRVVEIYELQARNI------------------LR-- T----NDI--IVDDAP-------ERRIVEIFELQKKSI------------------LH-- R----NDI--IIDDAP-------EVRICEIFELQVKSL------------------TK-- R----YDV--ILDEKP-------EVKHVEIFEILEQGI------------------TP-- K----KEF--INDEPP-------QGETVEIFELQRQGL------------------TP-- --TDWEFFKFSSTIFDP--------------------------------TDTYR------ --QEWSPYMYSTQVFDK--------------------------------SDPYR------ --NDWKFFKFSSSIFDP--------------------------------LDSYR------ --RYWRFLKFSNKVFEP--------------------------------ADQLR------ --NDWKFFRYSNRIFDP--------------------------------QDPYR------ --NDWRFFRFSNRIFDP--------------------------------QDPYR------ ------------------------------------------------------------ --NDWKFFRFSSRTFDP--------------------------------QDPYR------ ------------------------------------------------------------ --DEWDFYLLSSYAFDP--------------------------------TDKYR------ --RVWDFYKISSQVFDP--------------------------------FDSSR------ --HSWTFYRYSTTIYDK--------------------------------NNKAR------ --EDWSFLKYSSSVFDP--------------------------------DDNYR------ --NQWSFHRYTSNMFDI--------------------------------KNHAR------ --HSWAFYRYSTTIYDK--------------------------------NNKAR------ --NDWKFYRYSNTIYDR--------------------------------LNKNR------ --HSWSFYRYSNTIFDK--------------------------------NNKLR------ --RKWKPHAYSKRLFDW--------------------------------KDPVR------ --EKWTFYSYSGNIFDT--------------------------------KKKTR------ --NEWSFYCFTSSAFDV--------------------------------KNSTR------ --HHWKFYKFSNQVFDP--------------------------------HDQYR------ --RQWDSWVFTSLVYDL--------------------------------GSSWR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KALQL-------------------------P-PGVDKIEEIKPPAGWAFDE---- -----KSQKP-------------------------P-PGAHSMDDLKPPPTWTFDS---- -----RAQQF-------------------------P-PGVDSLQDVVPPPGWIFDP---- -----KAQQQ-------------------------P-LGVLDITEVLPPLRWEFDE---- -----RAQQF-------------------------P-PGVDSLADVIPPTGWSFDP---- -----RAQQF-------------------------P-PGVDSLDDIVPPAGWVFDP---- ------------------------------------------------------------ -----RAQQF-------------------------P-PGVDSLADVIPPTGWSFDP---- ------------------------------------------------------------ -----KSQRP-------------------------P-PGVTNIDEVVPPSMWSFDR---- -----KSQRP-------------------------P-IGVDTLEAVAPPPTWFFDQ---- -----IAGKR-------------------------P-PGVDHLSKVYPPNDWKFDF---- -----RAQVP-------------------------P-PGVDTLDQVHPPLTWSFDS---- -----AAGKR-------------------------P-LGVDDLSKVLPPPDWKFDM---- -----IAGKR-------------------------P-PGVDHLSKVYPPNDWKFDF---- -----LSGKR-------------------------P-PGVDHLSKVFPPTDWKFDA---- -----VAGKR-------------------------P-SGVEQLSKVYPPVDWKFDF---- -----VAGKL-------------------------P-HGVDNLSKVLPPPEWKYDF---- -----LAGKR-------------------------P-GGVDHLSKVVPPKDWLFDF---- -----SAGKK-------------------------P-QGVNHLYKILPPPDWKFDM---- -----KLQQP-------------------------P-PGVDNLKDIEPPRTWYFDE---- -----QAKKR-------------------------P-PGAPFLGDVEAPEGWLFSK---- ------NS--SWIIDKNPEIWAIE-RGLQ--------LPVEEG-------------FLVD ------NS--EWTTDTNVEQWATE-RGLE-------MTRIEGD-------------YLVD ------NF--EWKIDVDVERWVTE-RGLN--------LPTTGD-------------FLLD ------NS--NWEIDHDVSKWASQ-RGLE------TEMEIEGD-------------FLID ------NF--EWKIDNDVDRWVVE-RGLN--------LPITGE-------------FLFD ------NF--EWKVDDDVDGWVME-RGLN--------LPITGE-------------FLFD ------------------------------------------------------------ ------NF--EWKIDNDVDRWVIE-RGLN--------LPITGE-------------FLFD ------------------------------------------------------------ ------NS--KWEVDYDVKGWAQE-RGLS--------LEINGE-------------FLVD ------NL--SWEIDYDVTKWSSE-RGLN--------LEIKDE-------------FLLD ------GLVNKWNLDTKPKEFLRE-RSLNPNLFIVKNDESQG--------------WIYD ------NT--SWEVDHDTVSWASE-RGLD--------IPVDGE-------------FLID ------GYANKWEIDIDPQKFFKE-RNINNPYLQVHEDEKEG--------------WIYD ------GLVNKWNLDTEPNEFIRE-RSLNPNLFIVKNNESQG--------------WIYD ------EFVNKWVLDTNPMDFIKQ-RTLDASLFVIKDDENEG--------------WIYD ------GLENKWNLDSDPGEFIRQ-RSLNPSLFIIKEGEKEG--------------WIYD ------GYANNWHIDIEPQNFLWQ-RGIDMQHLECPSDETEG--------------WIYD ------GFANKWTIDYEPQEFLRQ-RSLESKNLVIREGEKSG--------------WIYD ------SYADNWHVDKEPQNFLKE-RSWDKLNMFVIKEDEDEG-------------WMYD ------NA--PWEVDPNAKKWSEE-RGLN--------LTISGQ-------------YLVD ------MH--DWEVDMNPNEWVGE-RGLG----RCTEMDNDE--------------WVYD PM---------------------------------------------------------- DQ---------------------------------------------------------- PM---------------------------------------------------------- PL---------------------------------------------------------- PM---------------------------------------------------------- PM---------------------------------------------------------- ------------------------------------------------------------ PM---------------------------------------------------------- ------------------------------------------------------------ DS---------------------------------------------------------- DL---------------------------------------------------------- NMEGIVYSDIVY------------------------------------------------ DS---------------------------------------------------------- KLDGVDNLDSSY------------------------------------------------ NMEGVVHLDIVY------------------------------------------------ NMKNVVNLEIVY------------------------------------------------ NMKDIVHSDIVY------------------------------------------------ KLPADDD----------------------------------------------------- KDVESQSLDITY------------------------------------------------ NEDMIENKDEQF------------------------------------------------ DQ---------------------------------------------------------- V----------------------------------------------------------- ---------FKRRRLVRKVIR--------------------------------------- ---------FKRKRLIRKVIR--------------------------------------- ---------FKRRRLIHRVIK--------------------------------------- ---------FKRRRLIRKVVK--------------------------------------- ---------FKRRRLIHRVIK--------------------------------------- ---------FKRRRLIHRVIK--------------------------------------- ------------------------------------------------------------ ---------FKRRRLLHRVIK--------------------------------------- ------------------------------------------------------------ ---------FKRRRLTRKVVR--------------------------------------- ---------FKRRRLTRKVLR--------------------------------------- --------EFRRRRLYRECYR--------------------------------------- ---------FKRRRLTRKVLR--------------------------------------- --------EFRRRRLSRECYR--------------------------------------- --------EFRRRRLYRECYR--------------------------------------- --------EFRRRRLYRECFR--------------------------------------- --------EFRRRRLSRECYR--------------------------------------- -----ISTEFRRRRLFRECFR--------------------------------------- --------EFRRRRLYRECLR--------------------------------------- --------DFRRRRLTRECFR--------------------------------------- ---------FKRRRLTRRVLR--------------------------------------- --EKGVRGEWRRRRFIRTAFK--------------------------------------- -------------------Y---------------------------------------- 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-------------------Y---------------------------------------- -------------------Y---------------------------------------- -------------------Y---------------------------------------- -------------------F---------------------------------------- -------------------E---------------------------------------- --------------KKPM-----KIKMH-------------------------------- --------------ANPA-----RIPSYR------------------------------- --------------SKPVT----------------------------------------- --------------ANPI-----PLPAHD------------------------------- --------------ATPVA----------------------------------------- --------------ATPLS----------------------------------------- ------------------------------------------------------------ --------------ATSIA----------------------------------------- ------------------------------------------------------------ --------------ANPA-----RKPTV-------------------------------- --------------ANPA-----RKPSYR------------------------------- --------------GRPH-----KQPSKY------------------------------- --------------ANPA-----RKPSYK------------------------------- --------------SRPP-----VIPKNT------------------------------- --------------GRPH-----KQPSKY------------------------------- --------------GKSH-----RKPAIK------------------------------- --------------GRPP-----KEPSGY------------------------------- --------------ARP------VPRFSVGT----------------------------- --------------GRAP-----KGSRKS------------------------------- --------------SRPP-----RQPKHD------------------------------- --------------ARPA-----NKPQI-------------------------------- -------------STVPK-----ELLGLV------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MKG--SKGRTDFNQRKNFNAVSQSSGSG---------LFHETGDVTRGFSDRLDYLL ---MRGA-SKKSSGSASSSKSRGNAAFNGTS--------SSFYETASVKKSFDERQDFLL ---MKGNFRKRDSSTNSRKGGNPDNNYTNGGSSNNQNNGSMFYENADTTKNFNDRQDYLL ---MKGNF-----------SANKKKDFANGKKLPTGVNNTTFSESPEVTKSFNDRFNYLL ---MKGNFRKRDSSTNSRKGGNSDSNYTNGG-VPNQNNSSMFYENPEITRNFDDRQDYLL ---MKGNFRKRDGSANSRKNGNVDSNYTNGGGSNNQNNGSLFYENAETTKHFEDRQDYLL ---MKGNFRKRDSSINSRKGGNLENNYTNGG-GPNQNNGLMFYESAETTKNFDDRQDYLL ---MKGNFRKRDSSTNSRKGGNSDNNYTNGG-VPNQNNSSMFYENPEITRNFDDRQDYLL ------------------------------------------------------------ ---MKGSL-------NSRKEGAFSSVTAGRT---GNDVGGSFYENEETKKAFSDRMNYVL ---MKGNFNNRR-----KDGNTGVPSNGIGRNTIVTSNSNSFFESPETTRNFNDRLNYLL ---MKGQSGHRR--------------------------------SNSRFANDDKRLVYLT ---MRGNLSGKSRDVNGNSSHNTYRNSNANA------GNGSFFETEETTKTFNDRLNYLL ----MGVNGHRRSNSRYNTGNYGNNSSQGQL-------------NNSDESINSDKLLHLV ---MKGQSNRASNVKNGHRR------------------------SNSRFANDDKRLVYLM RSGSKGEGGNGNGNGNGNGNGNGNGNGNSSGPLGQLDNNGSSGNFSSSEELGNNRLIYLI ---MKSQSNRVNNFKNGHRRSSS---------------------RASNDDSGNQRLVLLI ---MKGQVPGKSPAAAGNTSSNSSAAYQQGHRRSNSRHNTHHRESGSSTGVGSAQLVDLV ----------------------------------------------------NNRLLYLV -MKAQGNKPNGHRRSNSRQGTPPS--------------------STRTMSSEDDKLLFLA ---MRGNFGHNK----KRENGSPNRFGSSNRSSNQQNGSNIFFESAETTNSFNDRQDYLL MAEIKKNQSRQRKSVGGDRSDRSDRLDRSDRDRGDKKTANKWKRSPTHARHMHDRLLFLL VNGIGSNVKVTTTAGIQYEGVLAAANTEST-----NGIDVVLKHAKVIDNGMV-KDIDAL VNGIGNRAIVTITSGVKYEGLVAAWNPHSS----GKGIGVVLKYPKVLDKGFDESDINAL VNSIGSNATVTVTSGVKYNGLLVSCNLESS-----NGIDVVLRFPKVVDAGVS-NSIDDL TNGIGSNVTVTVNSGMQYEGILSACNLESP-----NGIDVVLQYPKIIHAADH-DDVDAL ANSIGSDVTVTVTSGVKYTGLLVSCNLEST-----NGIDVVLRFPRVADSGVS-DSVDDL ANSIGSIVTVTVTSGVKYTGLLVSCNLEST-----NGIDVVLRFPRMADSEVS-SSADYL ANSIGSNVTVTVTSGVKYTGLLVSCNLEST-----NGIDVVLRFPRVSDSGVS-SSVDEL ANSLGSDVTVTVTSGVRYTGLLVSCNLEST-----NGIDVVLRFPKVADSGVS-DSADGL ------------------------------------------------------------ VNSIGGRAVVTIPSGVKYSGMLLACNATTS-----NGVDVILKYPRIIDKGIDEEDAAVL VNSIGSETIVTVSSGVKYSGLLLACNPNTS-----SGIDVMLKYPKVVDKSFAGDAFDEI SKAMGKKCIATITDGSRYQGLLVGSDLSP--------LSVVLLKPQLVGSSLL-NEKNNL VNSLSTEATVTVTTGVKYSGILAACNPEGG-----NGVDVILESPKIVDKGFAANQVDQV AKSIGKKCIVTVSSGARYQGLLVSADLSSQQGQDSSPLSIVLQSPQIFSKSLI-DEKSNA SKAMGKKCIATITDGSRYQGLLVGSDLSQG-----SPLSVVLLKPQLVGASLL-NEKNNL SKSIGNSVIITTTDGSRYRGLLVATDLSKN----PAPLSVVIQHPQLVNKGLIDEKNNLD ASAIGKKCIATITDGSRYEGLLVASDVSPAQGSASAPLSVVLLKPKLVSKSLI-NEKNNL AKSCGKTVVATVSSGARYKGLLSSVDIPPS----GNGMSVSLVGPRLVTRALL-DEKSNS TKSIGKSCVATITNGARYQGLLVSADLSPTGS---SALSVVLMNPVNVGKSLI-AEKSNI AKSIGKPCVITVATGARYSGSLLAVDLAQN-----APASIVINKPTLLSGALI-TEKTNI INSIGSNVTTTTTNGIKYSGVLVSCNPESK-----DGIDIVLKFPKVISTEFS-DDIDVI AKSVGEHVTVTTASGDSIHGLLEGACTEGD-------LGVSMRFA---DSGA-------- AKSIEDTLLIQGEDVAEVDLKSIDFSLDEKWEAAQQQEAAKKAASPPSRSTSNTPAEGKT SAELSETLTIEPKDVAGVKLFDVSLDSDPLAAKEEES--------NPVESGKQAETSQKD ARTLGETLLIHGEDVAELELKNIDLSLDEKWENSKVQEATPARTESEKEKVSN-ESNEGG RAALKKTLLINGDDVAELELKNVDLTLDEKYETESPIKDSVVEETVPTTNAPQAAATSAT AKTLGETLLIHGEDVAELELKNIDLSLDEKWENSKAQETTPARTNIEKERVNG-ESNEVT AKTLGETLLIHGEDVSELELRNIDLSLDEKWENSKVQEATSVGADNEKDRSDE-GLNEGG AKTLGETLLIHGEDVAELELRNIDLSLDEKWENSKAQEVTSARASNEKEKVNE-EPNESS AKTLGETLLVHGEDVAELELKNIDLSLDEKWENSKVQEAASARANIEKERVNE-ESNEGT ------------------------------------------------------------ SAQLKETLLIEGDDVAELELLDVDFSLDDKWEQIKRREEQKARER---------RDGKLQ SESLQENLIIKGDDVAELDLKKVDFSLDEKWEKAKKYEEAKKTAEIEKEQ----KTEEKQ DK-LPENLIIQAKDLIDLEV-DVDLSE---------------------------PVKPPH ADDLQENLVIKGEDVAELQLHDVEFPRDEKWEKQPRTQKMDVKASPKKAPSSSLETRSKA DKEIPEKLVIQAKDLMDLEVSNVDLNESAKKDLNPRS--------VSPTSGSNTSTTHES DK-LPENLIIQAKDLIDLEV-DVDVGE---------------------------EIKAPP GKKLPQTLIVPAKDLIDFEIENIASEKHLEKTAAPKPETYSSAIESAMAQQPENTFSTKQ DK-LPENLIIQAKDLIDLEV-ALDLNEEVKP---------------------------RL DSDLPETLLIQAKDLIDVEIVLSRHGDDQAKNGGDQNKTASGEKKSKQTPPPVAVPTPQS DSDHLDKLIIQSKDLIDLEVIDVDLADV--------------------------ASNEES DAKLPDRLVVEGKNLIDFEVTTSLSGTEEPVPKQSSPLKSDSVATPPAAETKQESTESTS SNKLGKSLLIRGEDVAELELNDIDFSLDDKFEKNKKA---EIDASAKKEI----QEEIKQ -----KQLVFQPEDIVDVAVASAPLQVDQR------------------------------ GFRTDVDISRANKDIRERELQKWTPDTD-SAFNVD-TVALEDSNEKWDQFAVNEKKFGIK AFKTDTAISGAPKELKERELQKWSPDES-ESFPLN-NTSLEDDNGTWDQFAVNEKKFGIK KFRTDVDISRSGKEIKERKLEKWTPEEGTERFDINKGQALEDDSTAWDQFAVNEKKFGVK KFKTDVDISR--REFKERELQRWTPDGDTAAFDSSSAQTLEESSSTWDQFAVNEKKFGVK KFRTDVDISGSGREIKERKLEKWTPEEGAEHFDINKGKALEDDSASWDQFAVNEKKFGVK KFRTDVDISGSGREIKERKLEKWTPEEGTENFDINKGQALEDNSTAWDQFAVNEKKFGVK KFKTDVDISGSGREIKERKLEKWAPEEGTEHFDMSKGQALEDDSATWDQFAVNEKKFGVK KFRTDVDISGSGREIKERKLEKWTPEEGTEHFDINKGKALEDDSTSWDQFAVNEKKFGVK ------------------------------------------------------------ EFRTDTDIAG-AGEVKERELQKWTPDDS-EAFALE--GSLEDHAEEWDQFAVNEQKFGIT AFKTDVDISGSNMDIKQRELKKWTPEET-EIFELG--EDLEDSDANWDQFAVNEQKFGIK EFKTDADISG-KMQIKERELERWVPDDE---VELT----LEDDGSEWDQFKVNQEKFGVE EFKTDTDISGSGPVVRERELERWVPDDH-EAFDMG--EGLEDNSVSWNQFAVNEQKFGIT KFKTDTDISG-RLQVKERELQRWVPEEDSASFALE-DDTFNNSNETWDQFKVNEEKFGVE EFKTDADISG-KTQIKERELERWVPEDE---IEMT----LEDDGSEWDQFKVNQEKFGVE GFKTDSDISARGKPIQEREFVRWDAGNDLPSLTLEEEQYATNGKGKWDQFKVNEEKFGVE GFKKDSDISG-QIAFKERELQRWVPEDD---MELS----LEDDGGEWDQFKVNEEKFGVE RFKTDSDISS-GFHFRERELQKWVPDDNSKALSLE------DDSAPWDQFKVNEEKFGVE KFKTDTDISG-RTQFKERELQRWVPDEDIDHPALNNDTFGESSTGQWDQFKVNEEKFGVE TFKTDTDISATKAPVRERELQRWVPDDDSKMVSLE-----DSGKGHWDQFKVNEEKFGVG GFRTDIDISRASNNVRERELQKWTPDVD-DMAPLE-QQTLEESSSNWDQFAVNEKKFGVK KFRTDTDISG-RRAVAERELERWTPDADTSALTLE-----ESGTGSWDQFAVNADRFGVP SSFDEHFYTTKINKDDPNYAERLKEAERIAKEIESQDASGNVHLAEDRG-IAIDDSGMDE PSFDEHFYTTRINKEDPEYQKKLNEAERIAKEIESQGASGNVHIDEDRN-IKYDDSGLDE SSFDEHLYTTKINKDDPNYGKRLQEAERIAKEIESQGPSGNIHIAEDRG-INIDDSGLDE STFDEHFYTTKINKNDPQYQQRLKEADKIAKEIESQNTFGNVHLAEDRG-VIIDDSGMDE STFDEHLYTTKINKDDPNYSKRLQEAERIAKEIESQGTSGNIHIAEDRG-IIIDDSGLDE STFDEHLYTTKINKDDPNYGKRLQEAERIAKEIESQGTSGNIHIAEDRG-IIIDDSGLDE STFDEHLYTTKINKNDPNYGKRLQEAERIAKEIESQGASGNIHISEDRG-IIVDDSGLDE STFDEHLYTTKINKDDPNYSKRLQEAERIAKEIESQGTSGNIHIAEDRG-IIIDDSGLDE ------------------------------------------------------------ STFDEYLYTTKINKGDPNYETRLKEADRIAREIEAQGTAGNVHLAEERG-IVVDDSGMDE STFDEHLYTTRINKHDPEYKRRLREAEEIAKDIESQGTSGNIHVAEDRG-FFVDDSGMDE SSYDEHLYTTRIDTSAPDYHERVAKAERIAKEIEQQ-ATTDRHILEERG-VVVDDSGVDE SSFDEHLYTTRINKDDPDYEKRVKEADRIAKDIESQGSSGNIHLAEERG-IVVDDSGIDE SSYDEHLYTTRINTAAPDYHTKLRKAEKIAKDIENQ-TTGNRHVLEERG-IEVDDSGIDE STYDEHLYTTRIDTSAPDYQDRVAKAERIAKEIEQQ-ATTDRHILEERG-VIVDDSGVDE STYDEHLYTTRIDKSAADYKERLSKAEKLAREIEGS-STTDRHILEDRG-ISVDDNGMDE STYDEHLYTTRIDTSAPDYHQRVARAEKIAKEIESQ-ATTDRHILEERG-IQVDDSGMDE SSYDEHLYTTKIDTSAHDYAQRLERAEKLAREIEGN-ASGDRHVLEERG-LAVDDSGLDE ASYDEHLYTTRINTSAPDYHERVAKAEKLAREIELL-ATTDRHILEERG-LQVDDSGIDE STYDESLYTTKINTSGADYKKRLKEATIIAREIESQ-SSTDRHILEERG-IQVDDSGVDE STFDEHLYTTKINKNDPNFEKRLKEAERIAKEIESQGTSGNIHIAEDRG-IIVDDSGLDE STYDEHLYTTRINTEGPDYQAKMRRAQRLADEIEGQ-TGGNAHQREERG-DTVDDSGMDE EDLYSGVDRRGDELLASLKSNAKPAAPKPKKYVPPTLR---------NQPHHMDPAIISS EDKYSGVDRRGDELLAQLKLNAKPEAKGV-RYVPPSLR---------SQPHHADPAILST EDLYSGVDRRGDELLAALKSNSKPNANKANRYVPPTLR---------QQPHNMDPAIISS EDLYSGVDRRGDELLASLKTNAKPVTTKPNKYVPPTLR---------TQPHHMDPAIISS EDLYSGVDRRGDELLAALKSNSKPNSNKGNRYVPPTLR---------QQPHHMDPAIISS EDLYSGVDRRGDELLAALKSNSKPNASKGNRYVPPTLR---------QQPHHMDPAIISS EDLYSGVDRRGDELLAALKSNSKPNSNKGNRYVPPTLR---------QQPHHMDPAIISS EDLYSGVDRRGDELLAALKSNSKPNANKGNRYVPPTLR---------QQPHHMDPAIISS ------------------------------------------------------------ EDKYSGVDRRGDELLAQLKMNAKPALGRPTKYVPPSLR---------NEPHNADPAILSS EDKYSGVDRRGDELLAALKMNAKPSTSKSSKYVPPTLR---------SQPHHVDPAIISS EDKYSGVDRRGDELMAAL---RNASISKPA----QQGT---------TTHHHHDPAIVSS EDKYSGVDRRGDELLAALKLNAKSNPPKAKKYVPPTLR---------NQPHNTDPAIISS EDKYSGVDRRGDELMAALRNANISTESAPGKYVPPRQR---------AAQYHDDPAIISS EDKYSGVDRRGDELMAAL---RNASISKPA----QQGA---------TTHQHHDPAIVSS EDKYSGVDRRGDELMAVLGISNNNKNNQPQKYVTPRQR---------AAQYHNDPAIVAS EDKYSGVDRRGDELMAALRNASISNDANKPGNTTTTHR---------TAHYHNDPAIISS EDKYSGVDTRGQELMAAL---RIGNGSKPQ--LPPSH----------EQPIVTHAAKDAP EDKYSGVDRRGDELMAAL---RNASISNDT-----------------QKPETKVPEDVAG EDKYSGVDRRGDELMAALKNATITDEPKSDKYVTPRHR---------AAHYHNDPAIVSS EDKYSGVDRRGNELLAALKSKSKPTEAKPAKYVPPTLR---------NQPHHNDPAIISS EDKYSGVDRTK-------------------TYVPPSQRAELPHD---PNPTSSQPDIMSR TGTK---------------AVSPVTKHS-----------------AGLPRKEHRHKKVPN TG------------------------------------------------------KSKT SNSTNNENVAATTV-----TAAPAEAEV---------------TKEKASQKSPKSKKGLS TS--QTTKTTTTTTTTTSPVPKPTNGPI-------------SKSKEQPKAVAGDNHKASS SNSNKNENAVSTD------TSTPAAAGA---------------PEGKPPQKTSKNKKSLS SNSNNDENVAATG------ITSPAEAEA---------------IREKVPQKNSKSKKGLS TNSNNNENIVTTDIAAS--VEEPKEGNT--------------------AQKISKKKKNLS SNSNNNENAVTTDIS----TSAAAEVTE-----------------EKVSQKTSKNKKSLS ------------------------------------------------------------ TKK----------------GWSPPAP------------------------------KSPV T---TSKNMVSSD------TKKPTAKSP----------------------------SPPA SKQAKPESI----------PPKPPVPNE----------------------------SFRL RAAN---------------TSQPPAKHT-------------NDSRAKQPEAANEGKPVQP SAAQQKNDTETLTNPIV--NSMANKPDS---------------IPPKPQVANQHNESFRL LKQKKPDSI----------PPKPPVPNE----------------------------SFRL SAVKAPTPAPTPGQGQTPGGQAPGQGKA--------IAQQRTDSKKPPASAAVSNESFRL SKQKKPDSI----------PPKPSVPNE----------------------------SFRL AKQTKPEEKPAPEKPAQTGKPVHSEAGS------------------SSETSKSSENGGFR VSVAKAAKNTVPVKP----DSIPAKPQV---------------------SQQPHNESFRL S------------------AAGESKGDS------------------NAQVSKEYNESFRL TTTNKSSNIIGTSTNTTVADSNVPLTKSAKVETEVETKVETSIETKTEPKADSKTKSKIS LEQKKRNRIPGLPLNDPSATAAPSASKKPGFEKELASRYQKFIDLERNRMVSQKEAAKTH SKEAQIEELRKFSEKFKVPYDMPKDMPTSSKSTSSSATEASVDTPNTTTQSQPQATVNSG STRSEIADLKSFSEKFKIPYDMPDEVKTILKKDDQHEQPPSSASAVSTTASTPSPAPKTS SKEAQIEELKKFSEKFKVPYDMPKDMPEVLKRSNST------------------------ KKAAQLEELRKFSQKFKVPYDVPKDMNDIYRRSSES------------------------ SKEAQIEELKKFSEKFKVPYDIPKDMLEVLKRSSST------------------------ NKEAQIEELKKFSEKFKVPYDMPKDMPEVLKRSNSI------------------------ SKEAQIEELKKFSEKFKVPYDMPKDMPEVLKRSNST------------------------ SKEAQIEELKKFSEKFKVPYDMPKDMPEVLKRSNSA------------------------ ------------------------------------------------------------ DKKIQLDELKKFSEKFKVPYKMPEDVKTIFKKSEEL-------------------PSKSP DKKSQIDELKKFSEKFKVPYDMPEEVKSIFRKQEEE-----------------EESPKYT NAQSEINSLREFSANFKIPHKMPQDLLPILAKDKMKQDEILKKQQDHTKKEPKT------ KKKNQLDELKEFSEKFKVPYEMPEEVKTMLKKSGEG------------------SPQGVQ NAQSEINSLREFSANFKIPHQMPTDLLPILAKDKLKQDEILKKQKEQQLLKAQRREQKQA NAQSEINSLREFSANFKIPHKMPQDLLPILAKDKMKQDEILKKQQQQQQQQQIKKEPKT- NAQSEINSLRAFSANFKIPHKMPQDLLPILAKDKMKQDEILKKQQEQAKLQEQKQKQKQE NAQSEINSLREFSANFKIPHKMPQDLLPILAKDKLKQDEILKKQQSEQKKKESKS----- SAQSEFNALREFSANFKVPHKLPNDLLPILAKDKEK-----------QEEILKQQKAKEK NAQSEINSLREFSANFKIPHKMPSDLLPILTKDKLKQDEILKKQEQKKLQNEIEATSASQ NAQSEINSLREFSANFKIPHRMPTDLLPILAKDKSKQSEILKKQDKPKEVKDTSGSQSPQ GKDAQIEDLKKFSQKFRVPYEVPEDMKDFVKKSTSK------------------------ HDTARLNDLRKFSQDYKINTPVPEDLRPILAKDKSR------------DVSETTSPEAAN SNLKSD--------------------------PSLPPKPVN-------------KSSSTK STLKSN--------------------------PSLPPKPASQPPTTPTLANASGGKGSNR --LKSN--------------------------SSLPPKPIS-------------KTPSAK -----------------------------------TPTPAA----------IESTKGNTK --LKSN--------------------------SSLPPKPIS-------------KTPSAK --LKSN--------------------------SSLPPKPVS-------------KAPSAK --LKSN--------------------------SSLPPKQLAKLPLLELSLLLHRSRQGNQ --LKSN--------------------------SSLPPKPIS-------------KTPSAK ------------------------------------------------------------ SALKVN--------------------------PSLPPKPTPQPASSTATPSITPSKTSNR STLKSN--------------------------PSLPPKPVS----QPSAASTPGAPKANR --------------------------------YKLNPKAAV-------------FTPSSK AALKLN--------------------------PSLPPKPVSTTPIAPNSSGSTKNVRTSR ELTKSTDSLTDVQAQESGQPQQRKKMDPTRPAFKLNPKAAA-------------FTPSSK --------------------------------YKLNPKAAV-------------FTPSSK QEQEQKPKVHTPASPQKSQAQPSNTEKKPASKFKLNPNAAAFTPTFKPSQLTSPKNTNLA --------------------------------FKLNPKAAA-------------FTPSAK KDLKP---------------------------FKLNPKAAS-------------FTPNKA SQSNSE-------AQSQSQSPSKAKIDVAKPTFKLNPKAAA-------------FTPASK PTLLSK------------------RMDPTKPAFKLNPKAAA--------------FTPSK ---------------------------------------------------GESNEKHTK AHLDRV-----------------ASPMFDSLSSKLSSIQMSREADKSSEKSSSPAAADKN SSVPPTPS-TAKGELKKSSSSTSG----ASPSSATSPQATAHGVSPAGGRASVSSRR--R SSKAGTPA-LGKIEVRRGSQNKFN------------GSGKTPIASPSMARAETFGRR--- TVSPTAQTTTVKSESRRSTSNMSQ----------------GQSSAAHTTRSSTSSRR--R SGTPSSPN-SSKTETKAAQSSKTA----------------------------VHSKK--R TVSPTTQISAGKSESRRSGSNISQ----------------GQSSTGHTTRSSTSLRR--R IGSPIAQVSAGRTESRRSGSNISQ----------------GQSSAGH-TRSSTSSRR--R NLEEVAATCLQVNRRLVTPQDLVP-------------------------LGEDAIMV--- TVSPTTQVSAGKSESRRSGSNMSQ----------------GQSSTGHATRSSTSSRR--R ------------------------------------------------------------ NSKPSTPA-SSKVELKRPQNKFGP------------QSGHTPSNSPSAGRANTYRRR--- NSKPPTPN-LNKVELRKNHSRLNS-------------QGHTPVSSPSMGRSATVSRRRNV HATISSP--------KKSPRPYSN---------------------------GNVKKHYQI GSTPS----AGKDELRKPPTRMSQ--------------GHTPVSSPSSSRHANISRRRNI HTQLSPN--PPKANFHRPPNNSSP--------RMGNQRPFTSGSGSSVGSNTNSKRHYQI HATITSP-----PSFKKSPRPYSN---------------------------GNVKKHYQI PVPPIPQIPPQIPQAPVPPVSQVPQVPQVHGSSSAYQSPRTATSRASNGNVSHTPKRHQI HATITSP-----PNFHKSPINPSP----------KVSHPRPYSSNGSVSSQGSAKKHHHV TSPV-----PPKASFKSPGTASPR-------------MNTSRPYGPGSSGSATTKRHHQI HTQISPT--PPKASYHRSPNNPSP-----------RMNHQRPFSNGSVSSGSSVKRHHQI SSQMSSP--VPSKAGFRSPVNPSP-----------RLNNQRTYTSGSSSGSGNSKRHYQI SSSSTAP--TSKSESRTRDGKSQQ---------------------SGSGRSSTGSKR--H GGTAADN--KPEPVAKSSPSKPKF----KMNFKAPEFKPFTPKDTNAQLATAAAPEP--- NAGSFFG-SKKLQSK--DNVRKAFATSFNMFLRSKEAHDQKASSSDEKKHTEQFFIEKPY RQRNFFD-EGKP-----KCLKKDLNKNFNMFLKAKEAHESK-GKDSEGKNLERFFIEKPY NHGSFFG-AKNPHTN--DAKRAAFGKSFNMFIKSKEAHDEKQREHDASENMEPFFIEKPY NPGSFFG-HKKPTAN--VSKKDLFKKNFNIFLKSKESYDKKNNESSETKSMEPFFIEKPY NHGSFFG-AKNPHTN--DAKRVLFGKSFNMFIKSKEAHDEKKKGDDASENMEPFFIEKPY NHGSFFG-AKNPHTN--DAKRAAFGKSFNMFIKSKEAHDEKQRGDDTSDNMEPFFIEKPY ---PFLG-LKILIL---MTPRESLSGKASICLSNPKRHMMK--------NREAIMYR--- NHGSFFG-AKNPHTN--DAKRVLFGKSFNMFIKSKEAHDEKKKGVDAPENMEPFFIEKPY ------------------------------------------------------------ NNPPFFG-DDGP-----KCLKKDFKKNFNVFLKSKEAFESRHKQTAEGKAMDAFLIEKPY SPSSFFG-NKAPQA---NDVKKDLSKNFNMFLKAKEAHDERKKQGGATNSLESFFIEKPY SAADFFGVNKVPTKDGQTTKIKEFKCGFNMFVTTRRKHKE---------------YEKSF SQGSFFG-SKTP-----QASKKSFVKNFNMFLKAKEAFDEDSTGNSKDKNKGVFVIEKPY SPADFFGADRIPTKEGQEQKIKDFKFSFNLFITTKKKAAAD---------HTPVNFEKTF SAADFFGIGRVPTKEGQIKKVGEFKFGFNMFVTTRRKHKDG-----------PVVYEKSF TAQDFFGANKVPTKDGQASKVKSFQTGFNLFNHAKKKAKES---------GTPVVFEKLY SAVDFFGNDKVPTKESQKQKITSFRRGFSMFVTTRTKQKDG----------NPVVYEKTF SAADFFGADKVPTAEGQKEKISRMRQSFSLFTHAKQQAQKT-EENAGKETVKGPVLQKPF SPADFFGADRIPTKESQIKKVESFQFAFNLFVTTRKRHAEK--NEKSEKKSDTVVYDKTF SPAEFFGSDKVPTKDTQKKKVEQFKISFNLFITAQKTQNTK-----------TPTIEKTF SQASFFG-SKVPQAN--NNKKALFTQNFNMFKKAKEAYDLKNSDKSESKTMERFMIEKPY SSPAFF--SSTP-----KTDRAPLSTLFNPFKKPKAENTP---------------FPRAF FTAPTWA---STVEKSFKEFFPDERKALQKAQSRLQKRQMNAMNAGMMGSNPHMGV-MGG FTSPTWV---STVDQSYKSLFPDERTAIQRTQMRLQQRSIDMMAQG-------MATGPGG FTAPTWL---NTIEESYKTFFPDENTAIQEAQTRFQQRQMNSMGHGGPGMNPNMGMNMGG FTAPTWP---NTIEKSYKTLFPDQKKLVQRAQRKMQQRQMNPMSMGPSLANPHMGVSMGG FTAPTWL---NTIEESYKTFFPDEDTAIQEAQTRFQQRQLNSMGNAVPGMNPAMGMNMGG FTAPTWL---NTIEESYKTFFPDEDTAIQEAQTRFQQRQMNSMGNGGPGMNPNMGMNMGG ---RIWN---HSLLKNL--ILPRRLGSIQ------------------------------- FTAPTWL---NTIEESYKTFFPDEDTAIQEAQTKFQQRQLNSMGNGAPGMNPNMGMNMGG ------------------------------------------------------------ FTTPTWI---STMDRSFRTLFPDERTAIQKAQLRLQHRIMNAIGGNMP-----MGSIPGM FTAPTWI---GTMEQSYQTLFPDERTAIQKSQMKLQQRSMNAMAAVG-----NHMGGIPT QTPPTWE---STVDVAHDKLFTARPIVAPVAPPIYANK---------------------- FTPPTWA---SNVEQSYKALFPDERTAIQRSQMKVQQRTMSSMSSPG---TPNMMGMPGM YTPPTWN---STIDDTYDKLFPSPNTIRGLPTSTSMPFMPSPMMGAP---SPVMQSGFPG QTPPTWT---STVDVSHDKLFSARAVAPS----QFVP----------------------- QTPPTWN---STIEETYTTLFPRSTYNVY---------GVGSVGGSTPG----IGSTTPL QTPPTWD---STVEEAHNKVFARHVAATP--------FVPSPMMAAP------------- YTPPTWD---STVDETYEELLASQTSKSNRAPMMAPVPGMPYLGNPLM------------ QTPPTWD---STFDDTHDKLFPALSYVNA-------PAIPNAYGGAPAG----------- ITPPTWT---FTDDLPHTSLFPTNANRKT-------MMSPTPMPFSP------------- FTAPTWD---STIEQSYKNLFPDERVSAQKAQMRLQQRQMNSMNAAALA-NSQMGMSMGN ETHPTWHTVEAAADSSV--LFPPLEQ---------------------------------- MGGFAMAPM----SGSGANPAMMN---------SFGGMYMP-----FQPQPVFYPGMVPM ---MPMGMPVGVPTGGP--PFMGG---PGATAGSHGGMFMP-----FQPQPMFYPPMGGQ MMGFPMGGP----SASPT-PMMNG------FAGGSMGMYMP-----FQPQPMFYHPSMPQ MMGFPMGPT----PTSPN-QMMNA------SFANSMGMYMP-----FQPQPMFYPGMPPM MMGFPMGGP----SASPN-PMMNG------FAAGSMGMYMP-----FQPQPMFYHPSMPQ MMGFPMGGP----SASAN-PMMNG------FAANSMGMYMP-----FQPQPMFYHPSMPQ ----------------------------------------------LKNLTRHFSPMRTQ MMGFPMGGP----SASPN-PMMNG------FAAGSMGMYMP-----FQPQPMFYHPSMPQ ------------------------------------------------------------ MA-MPVGP-----AGSQSTPFMAS-----------PGMFMP-----FQPQPMFYPP-VPQ MMGFPMGP-----GGAPG-PFMNG--------PAVGGMYMP-----FQPQPMFYPP-MPQ ---FPMSPQAAAMMQQQQ----------------------------QQQFAMMFPPQMPV MMGMQMGP-----NGSPN-PYMMG-------PNANAGMYMP-----FQP-PAFYPPMMQV MPGTPTG------NKFPLSPQQQQ-----QQQQAAAAMAAH-----FQQ-QQFHAAMMYQ ---SPMVAP------GPI-PYVNKFAMQQQQAAAAAAMVVQ-----MQQQQQQQQQQQQQ QLSSPL-MATTPPGVSPQLPIMQGVPIPGGGAPLPYGFLIPPQFHQFQPHQQYLQQQLPQ ---IPYG------NKFPMSPQQQQ-----QQAAAAAAMVVQIQQQQQQHIPHHGHPQQPH ---MPAGGPQLAAGGFPG-PAVASKYPVSPQMQSPATMAAQ-----FQQQQQLQAMLYQQ -------------SKYPVSPHQQQ------AAAAAMAAH-------FQQ-QQFHAAMMYQ ---SPLMGAPMVPANYAGMPPPNGKFPMSPQHQQAAAMAA------MQQQQQMHAAMMLQ MMRYPM-------NTGSGNPMMNG----------AMGMYMP-----FQPQPVFY-PSMPQ ---LTMQRPFLHNAMSPQ---------------RGGAVMMP-----FYQMPQGVPPMMYQ MGTSTSANTGRGNAGAHPSGSMSPQAMSPHIPPAYMAGAPMAYPAP----PGAAPFHGMM M-MPMMNSRNDTRNGSG----ANSQSSSPPATTGFMNG--VPMNVPYGY---PMRYQTMG M-MPVMGNNGAEEGGGN---------ISPQMPSGFMAAGPGAPMGAFGY-PGGMPFQGMM MTPGATGTGAVSKEGLDSGSSPSPQAASPHIPPAYMAGPGNQAMGGFGY-PGAMPFQGMM M-MPVMGSNGAEEGGGN---------ISPHVPAGFMAAGPGAPMGAFGY-PGGIPFQGMM M-MPVMGNNGAEEGGGN---------ISPHMPTGFMAAGPGAPMGAFGY-PGGMPFQGMM L----------------------------------------------------------- M-MPVMGSNGAEEGGGN---------ISPHVPTGFMAAGPGAPMGAFGY-PGGMPFQGMM ------------------------------------------------------------ M-LTMVGGPADDRRNST--HSPSPTTNSPHGAPAFING---APIGPFGY---PAAFQPIM M-MPMMGSGDGKKSGAG---SPSPNTSSPHGAAAFMNGVGAGQMAPFGY-PSGMPFQPML F--------YGDP--------------TFYPPQGFVPP---------------PQFGNPM M---HVGEERVNPGTTP----PPPNAGSPHGGPAFINGAPTGPISPFNY-SGAVPFQPMM QQQHQQQQFSGVPPGQPPMPMYGPGGEPPFLPPGFMMP-------PGNFNAGGSPVNGNV Q-----------QQQYA--MMYQQQF-VPQMPVFYGDP---TFYPPQGFVPPPAQFGNPN QQQQQYQQHYQQQQHQQ----HQQQYQQPHFPQVAAAP--------MWFIPPPQGFGMMN H-------PQQQQQQYA---MMYQQQFPPQVPMFYGDP---TFFPPAGFIPPPAQFGNPN F-------QGGGPPGQP--HLMYAPPDSQFIPPGFMIP---------GFANPGSPVNAAA Q-----QFPVGIPPGQPPMHMYPGGEPPFMPPGGFMPP-------PGGFVAGGSPVNGNM H-----QQHLQMSPGQAPVPMFPQADMGQYFPPGYVPS-------PTGF-GNVSPNGNVM M----MGVMGGTDDATS---PVSPQATSQQFGPAYGIP--GAPVAAYGY-PTGIPFQAMM Y--------------------GPQFVQQPFGPPGYRVP-----------MPPGQPPQGYM GGMPDRS-------------HGNYYHNNHGHRNNHHHYHSKQYN----SGKGVYR---KS GPPLQQQQHQQKQ------------------FHQNHTRNYRQHNDSR-MGKGAAKYGYKS GSGPSGMPASGSTIHSHGHGRNYHQSN----HHGHRNNSTSGHK----MGKGVAKYGFKS GGNVAPNGMPRQNYH-QGHGHHNHHNPNNHRRHNNNNNNGNAKNQTENMGKGAAKYGYKS GSGPSGMPANGSAMHSHGHSRNYHQTS----HHGHHNSSTSGHK----MGKGAAKYGFKS GSGPSGMPASGSAMHSHGHGRNYHQTA----HHGHHNNSTSGHK----MGKGVAKYGFKS -------------------------------FKRLKPNSNNAKX----MGKGVAKYGFKS ASGPSGMPANGSAMHSHGHNRNYHQSS----HHGHHNNSTSGHK----MGKGAAKYGFKS ------------------------------------------------------------ APVGTGNVNGVAGPNGNGSNYKNHY------HHHNNGNRYHRHR----MGKVIAKFGFKS NAPNAGNHAGNYRTNYLPNTHHNT-------HHNSRHNRSHENR----MGKAAVKKGLKS MM---------------GNPYGRRYTKKH-------------------MGRNVLKYGGKS GSRSFRQHAQNQP------------------YQPHQNRHRTHDH----MGNGAAKYGFKS MM--GGSPYNNVSGNQMNANYNNHHQGGSSGRYNNHHNQNSQHNHKRGMGKRTIKFGGKS MMMGNPYQY----------------------QGRRYSKKGGQH-----MGRNVLKYGGKS NP------YQNAAPGGHNHGHG---------HGHGHGQQTRRYK----MGKGALKFGGKS MMMGNPYQYQG--------------------NRRYSKKGGPGHS----MGKNVLKYGGKS GFTPGHNNY-------NGHPHHNR-------RYNGQGKRGNHHS----LGKRTLKYGGKS MLNP---------------------------YNAGGHNYNSHH-----MGKGVLKYGGKS NQYGSPMPY----------------------NRRFGPKRT--------MGKRALKYGGKS GN-----NANSTGGHYRGNNHNNNHYNH---HHNHGNNHNKNNYENRSMGKNIAKYGYKS RYQG--------------------------------------------MSSRV------S GTLPVTRQILKKPTGQKYLLDELKKPKPKGGYAAGVLQPRGSHRISPPVEFVDVEKLIDS GILPSTRRILKNPVNQTGILERVKEAKPKGGYAKGIKHPKGSHRNPPPLKFIDVEEVIYN GVFPTTRSILKNPTKQTDIINKVKSPKPKGGYAKGVQHPKGSHRLSPKVDFINVDKLIEK GVLPLTRSILKNPTKQQSIIAKVKAPKPKGGYAPGVLHPNGSHRHPPLVKFIDVEQLIEK GVFPTTRSILKSPTKQTDIINKVKSPKPKGGYAKGVKHPKGSHRLSPKVNFIDVDNLIAK GVFPATRSILKNPTKQTDIINKVKSPKPKGGYAKGVQHPKGSHRLSPKVAFINVNNLIAQ GVFPTTRSILKNPTKQTDIINKVKSPKPKGGYAKGVKHPKGSHRLSPKVEFINVDTLIAQ GIFPTTRSILKNPTKQTDIINKVKSPKPKGGYAKGVKHPKGSHRLSPKVTFIDVDNLIAQ ------------------------------------------------------------ GILPKPRPILKHPVNMTAKVQEALAPKPKGGYADNIAHPAGSRREPEPVKFIDVEQMIKA GILPATRSILKNPIRQQSVIDQVKAVKPKGGYAPNVVQPRGSHRHSPRVEFLDVEKLISK GILPKVRPIFRKPIRPPTEYEQAKEHSIETGYAEGIPLPKINSRKQPPKKYVTVEQRINQ GILPNARTILKNPVKQTTLLDKLKAPKPKGGYAKNIAHPRGSHRSSPRVEFVDVENLIAK GILPKVRPVFKRYIRPKTAEELADESKVEQGFAEGVPLPTRKHRQTIEKPVVTVEERIKK GILPKVRPIFRKPIRPPTEYEQAKEDSIETGYAEGIPLPKINSRKQPPKKYVTVEQRINQ GILPKTRDIFRRPVRPLKNWEQEIEDSKESGYAEGVPTPVIKPRQTPARKYITVEEKIKE GLLPKVKPIFNKPIRPPTVYELANEKTSETGYAEGVPLPIIKPRQQRSKKVVTVAERIQQ GILPEVRPIFKRNIKPKSEHQKHEEAQIEQGYAEGIPTPKKRHRKPVERPVITVEERIKR GILPKVRPVFKRNIRAKTAYEIEKEAHLEHGFAEGVPLPKKTHRIQPEKKVISVEERIKL GILPEVRPVFRRYIIPQPPSDTTNQ-----GYADGVPLPSKKEREPIQRPVITVEERIKQ GVLPVTRNILKKPVNQTTLVEKANAPKKLGGYAEGVQHPRGSTRVQRPMEFIHVEKLIKK GVLPKPRSIVVPYSRRGFPVGQ--------GYADEKMVPRGSHRFPKKKTVPTEEQLIAT TRTPSKDTEARSQQAKDKLNKAELRRQYLAESFRKEEERLIKMHELIQREQLVQEQRQRE T-KPKSENTAASEQQLLKQNQAELRRKYLSESLRNEEQRLLKQEELLKKERVLQEQREAE TAEPQSIKSSNGAAQKIRLQKAELRRNFLIEAFRKEEAKLLLKHEYLQKTKELEKTKELE TAAPKTVPKMNSPEQEARAKRSQLRREFLTKAFKNEEQRLLRREELLKKEKILELEKTER TAEPQSIKSSNGSAQKVRLQKAELRRKFLIEAFRKEEARLLHKHEYLQRTKELEKAKELE TAQPQSVKSSNGKAQKIRLQKAELRRSFLIEAFRKEEAILLQKHEYLQRTEELKRIRELE TAQPQSIKSSNGSAQKIRLQKAELRRNFLSEAFRKEEAKLLHLHEYMQKTKELEMAKELE TAEPQSIKSGNGPAQKIRLQKAELRRGFLIEAFRKEEARLLHKHEFLQRTKELEKAKELE ------------------------------------------------------------ TPEPQQARQPASEQQAAKNRIAAMRREYLSDAFRAEERRLLRQEELLRRQQLLEEESQRQ TAEPQIVKAAATQQQEAKQRRSELRRQYLADAFRKEEERLLKQEILLKKQELLEQERHKE IKFPELTLNELPEEERDAYKRQYYRAQFLKDAYLQEEKRLNRIDELKEHQQNLERQARLQ TPEPQNTTVPKTAQQEAKQQKAEMRRSYLSEAFRNEESRILRQEKLLHKQAAQAEERQKE NRKPQNIDSKLSQEEIWKLRRDDIRREHLREAYLNESKRLQRIEDLKKIQAEKELSAKAS IKFPELTLNELPAEERDAYKRQYYRAQFLKEAYLQEEKRLNRIDELKEHQQNLERQARLQ IKYPSMTLNELPDVERDEQRRAYYRAEFLKEAYLEEEKRLKAIDEIKEHMQNLERQRRFD IKFPELTLNKLPADERDAHRREFYKAQFLKEAYLEEEQRLQKIDELKQHEKKLKRSQEAH FRAPDVDKSKLSQEELWELQRDEVRRQHLKDAFLAEAKRLERLEQLEAKKQEQEQKHKDQ NKAPQNVDLKLTQDQIWKLKRDEIRRDYLKQAYLTEASRLKKIDEIV-AQQEEKKKHQTE NQAPKEPISKLSTDELWRLKRNEIRREHLREAYLKEAERLKRIDELKAREEKRLREA-KQ TSKPKVEHDVSTPQRLAKHEKSELRRRYLAESFRKEEQRLISLEKLVKKELALKEEHIRE RNPPRTSATPRSEIHKWHLKMADLRKQYLADSLVSAERADKAKYHYHKYLAAAEKVK-ED MEELNEPRSSDLTIPSLNEMVSGKLMRDRTPEEKELLEMKRRYNRETQELRIQENKLKKL LKELNKERSSNLTIPTLEGIMNQPLMRQRTAEEQEILDLKRKHNKELIEFKAKERKLANL LEKLNKEKSSDLTIMTLDKMMSEPLLRNRSPEETQLLSLKRNYNRSLLNFQTYQNKLNKL ENKLLKEKSSDLTIPTLENILEQPLIRWRTPEERKILQLKRKFNRDLLEFQTKERKMEKL LEKLNKEKSSDLTIMTLDKMMSQPLLRNRSPEESELLKLKRNYNRSLLNFQAHKKKLNEL LEKLNKEKSSDLTIMTLDKMMSQPLLRNRSPEETKLLKLKRDYNRSMLNFQTHKNKLNKL LEKLNKEKSSDLTIMTLDKMMSQPFLRNRSPEETELLKLKRNYNRSLLNLRTYKTKLNKL LEKLNKEKSSDLTIMTLDKMMSQPLLRDRSPEESELLKLKRNYNRSLLNFQAYKKKLNEL ------------------------------------------------------------ LAEATRERASDLTIPTLEELVNEPLMRQRTPEEQKLVDMKRKHNREVLALRIQERRMAQL LAALNETRSSDLTIPTLENILNEPLMRQRSPEETEVLNLKRKHNREVIQLRAKERKLEDL QEEKLEHQNKNIGLPTMQALLDKGMMRRRTKEEIELLKEQRNLNRKLKELQDKENQAQKV LQALNETRSSDLTIPTIDKMLQGPLMRQRSPEEREILKLKRKHNRDVLQLRAKERKLENL QSIYEETEATKLTLPTIDSYLNGPIMRQRTEEEQEIVTEQRILNRKTKELAVKERKTNQL QEEKLEHQNKTIGLPTMQALLDKGMMRRRTKEEIELLKEQRNLNRKLKELQDKENQAQKV AE-IAAGSSEVSSLPTIQKILESNMIRPRTAEEKELIKQQRNLNRNAKELQDKEEKAQKL EEEVLEHDRSVKGLPTMQALLDNGLIKQRTPEETELLKQQRILNRKTNELQQKEAQAEKL QEHFEESVATKLTLPTIDSYLKGPIMRHRTPEEQAIVNEKRTLNRKATELAVMESKATDL LDDYEESDAVKLTLPTVDSYLKGPIMRNRTKEEQQLVEQQRLLNRRVRELEVEEKRADDL QTVHEESEATRLTLPTIDSYLEGPIMRPRTEEEEALKAEQRLLNRKGQELSLKEKKATEL LKELEKSKTSDLTIPSLNRILNEPMMRERTEEEKEILAMKREYNNNLMEFKAKERRLQNL ARNAGLTEAELLTLPTISGLLTNSQLKRQTEDEYEQKRLERQYNDQLQQLKDEEERARVT LNLYHMSSEFITTEEQLLATIENVFSTRTATDSIKSLPKNSI--TKGNNAFAQDLFFGTN VQLCHAADHFIVTEEQLVASVEKAFASDNQDVLRNKLSLSTSQQTARNEGEISDALFGTL LNLYHVANEFIVTEAQLQKKIDKVFNDETQEFTQFGSRKSLLSGNSTFQTKINNAIMGSL LNLYHIADEFIVTEKKLLQKIDEIFDDKYIHGHSRILESEKSIEKRILENDIGDAIFGTL LNLYHVANEFIVTESQLLKKIDKVFNDETEEFTQFGNRKLLLSGNTTLQTQINNAIMGSL LNLYHVANEFIVTESQLLKKIDKVFNDETQDFTQFGNKKSLLSGNSTLQTQINNAIMGSL LNLYHVANEFIVTEPQLAKKIDKVFSDETQEFTQFGTRKSLLSGNSTLQTTINNAIMGSL LNLYHVANEFIVTESQLLKKIDKVFNDETQEFTQFGNRKSLLSGNSTLQTQINNAIMGSL ------------------------------------------------------------ VSLYHAAEEYIVTEPQLLRHIDEVFSSENAHTLKNRPLVSASGRENENERAVLDTLFGTV LKLYYIADEFIVTEKQLLKKIDEAFANESSEALRTKLSVGASRQKTRNEKDIGDALFGSL LELYHAAANFITTEEQLEEAIHRAFEVDVGVEAKLENRSLGYLTAEANEQKITDVVLGEI LKLYHVTSEFIVSEAQLVKKIDEVFANESSEALRTKLSVGASRPKSRNEKDIGDALFGSL LELYHAAANFITTEEELEQAIKDAFEVNVSKENKLSGYSHAFSNINTNEGLVLDEVLGQV LELYHAAANFITTEEQLEEAIHRAFEVDVGVEAKLENRLLGYLTAEANEQKIKDAVLGEI LELYHEAGKYITNEAQLEDAIHKAFELDEGADNKISGVRKDNGISRINESVIADVILGEI LELYHAAGKFITTEKQLEEAIHQAFEVDVGVEAKLANKSLGYMAAEANESLIADTILGEI LNLYHAASTFITTEEELEVAIKDAFEVKVGKEDKLFGFHNSYNNAKTGEKLIQDAAFGEI LDLYHAAANFITTEEELEAAITEAFEVNFSKEQRLASAGPGYATVDYNERLITDHVLGEV LELYHAAANFITTEEELERAIEDAFDVNVSKENKLSGYSHAFSSIQANEALITDEVLGEI INLYHISNNFIVTEEKLLKEIEIAFSYEGSDRLRNSLGADFNKVRIRNENSIGDSLFGSV VQLIDQADDFIVTEEQLIAGVEKAFVNGSSSAGLEKLVSLASESEESKLTEIGDAIALEL TRNVGLPMVQDFISGELNRLHTKAKENLEVQ-------------MKPTTNKKAKMKLPNI GNGVGLPIVKEFLSGEMEQFNQEINTKLDEL-------------MHLIHQSIKRF---YT TNEFDVSLVDSFLNNDLRNISGRIDSKLNGS---------------------MNIGGGRF GGGVGMPMVNEFLNGETKQFNDKVDEKIREK-------------MPA-----------KI SNEFDISLVDSYLNKDLKNISNKIDSKLNPT---------------------MNIGGGKF TNEFDISLVDSFLNKDLRDISDRIDSKLNLS---------------------MNIGGGRF TNEFDVSLVDSFLNKDLRKISDRIDSKLNLS---------------------MNIGGGKF TNEFDISLVDSYLNKDLRQISDRIDSKLNFS---------------------MNIGGGKF ------------------------------------------------------------ AAGDGLPAVRDFLAGEQRAAASAPAPDSASQ-------------MGFWIRPYST----QR GGGIGLPVVKEFLSGEMREFAEEVEAKNKQIPRINLGVKPLSNFRLYATKQDNLHAVKRN DGKPGLQQVKELLSGEREKVKRQAQLNLKNN-------MKTIRYLSHTTRLLAKSTSTPK GGGVGLPTVKDYVSGEMNSFAAEVEARNEAL------------MRNLIVKRFYATSKGFT NGQPGLETVKDTLDGEIERLKREAQLAINQRNYFQKSLRYFSISSKALAKKKNAGVIKTK DGKPGLQQVKELLSGEREKVKRQAQLNLKNN-------MNTIRYLSYTTRLLAKSTSTPK DRKPGLNQVKDALNGTREQVRREAQANFHD---MQVYRGFSTCVPRLAKQTTNASGSVNK NGKPGLKQVKQVLDGTREQNKRNAQLGASK-MFYRTIRCFTTGTRLSAKAAMSTSEKSRK DGQPGLDAVKETLSGEAESMRRDAQARLNHNEPMSFLRSFSVSCRALAKKPSPQK---QK NGKPGLATVKDTLSGEKERLSRDAQVAINQE--MRIFIRSFSNSFTKWAKKPVSGAKLKN DGQPGLSTVKSTLDSEIERLKRQAKMVINQG-MNSFRPFSSSSRILAKKASESAK---KA GGGVGLDTVKDYLSGELNEFSKQIDEKFIQD----------------------------- TGTPGLGRIAEILRGD-NVLERAEKLRLDQT----------------------------- LDALKTNNPTSGIVGLANVGKSTFFQTITNSHLGTAANYPYATIDPEVA---KVPIPSPE VLGRPSNNLASGIVGLANVGKSTFFQAITKSKLGNPANYPFATIEPEES---KVIVPSFK LLGRVSNNPTSGIVGLANVGKSTFFQAITNSKLGNPANYPFATIDPECA---KVNIPSTP ILGRASNNLTAGIVGLANIGKSTFFQAITNSKLSNPANYPFATINPEEC---KIQIPNDK LLGRISNNPTSGIVGLANVGKSTFFQAITNSKLGNPANYPFATIDAECA---KVNIPSVP LLGRVSNNPTSGIVGLANVGKSTFFQAITNSKLGNPANYPFATIDPECA---KVNTPSVP LLGRISNSPTSGIVGLANVGKSTFFQAITNSKLGNPANYPFATIDAECA---KVNIPSVP LLGRVSNNPTSGIVGLANVGKSTFFQAITNSKLGNPANYPFATIDAECA---KVNIPSAP ------------------------------------------------------------ AIVRASNNLTSGIVGLANGGKVTFFQAITKSTLGNPANYPFANIDPEEA---KVLVPSEH FLGRPSNNLTSGIVGLANVGKSTFFQAITQSKLGNPANYPFATIEPEEA---KVIVPSKR VLGRASNNLSVGLVGLANVGKSTFFQALTKSTLGNPANYPFATIEPEKS---IVLVPSDK RLGRPSNNLTSGIVGLANVGKSTFFQAITNSKLGNPANYPFATIEPEEA---KVIVPSKQ YLGRPSNNLTLGVVGLANVGKSTFFQAMTKTSLGTAANYPFATIDPVES---LVIVESPK FLGRASNNLSVGLVGLANVGKSTFFQALTKSTLGNPANYPFATIEPEKS---IVLVPLEK LLGRPSNNLSTGLVGLANVGKSTFFQALTKSTLGNPANYPYATIEPEKS---IVLVPLEK ILGRASNNLSVGLVGLANVGKSTFFQALTKSKLGNPANYPFATIEPEKS---MVLVPSNK FLGRVSNNLSSGVVGLANVGKSTFFQAITKSTLGNPANYPYATIDPEQS---QVVVESPK YLGRPSNNLSLGLVGLANVGKSTFFQAITKSTLGNPANYPFATIEPEKS---LVVVPLIK LLGRQSNKLTAGVVGLANVGKSTFFQAITRTSLGNPANYPFATIDTEES---QVVVKSPI MLGRNTTNLKAGIVGLANIGKSTLFQAITNSKLGNPANYPFATIDPLDY---RIPIQNEK ------------------------------------------------------------ LP--VLQKL---YQSGKVIPAALTIYDIAGLTRGASEGHGLGNKFLSDIRHVDGIFNLVR LD--HLHKL---YESQKKIPATLSIFDIAGLTRGASSGEGLGNKFLNDIRHVDGIYQVVR LS--DLSRI---YQSAKTVPGTLTIYDIAGLTRGASQGHGLGNKFLNDIRHVDGIFQVVR LD--HLQKL---YESKKQTRSILTIFDIAGLIRGASQGNGLGNKFLNDIKPVDGIFHLVR LS--NLLRI---YQSAKCVPGTLTIYDIAGLTRGASQGHGLGNKFLNDIRHVEGIFQVVR LS--NLFNI---YQSAKIVPGTLTIYDIAGLTRGASQGHGLGNKFLNDIRHVDGIFQVVR LS--NLLRI---YQSTKIVPGSLTIYDIAGLTRGASQGHGLGNKFLNDIRHVDGIFQVVR LS--NLLRI---YQSAKSVPGTLTIYDIAGLTRGASQGHGLGNKFLNDIRHVDGIFQVVR ----RLXKE--------------------------------------------------- LD--HLQKL---YGSRKKIPATLTVYDIAGLTRNASRGEGLGNKFLGDIRLVDGIYSVVR LD--HLQRL---YQSEKKIPATLTIYDIAGLTRGASQGEGLGNKFLNDIRHTDGIYQVVR LT--HYAKL---YSSQKTVPTNLTIWDIAGLVRNASSGAGLGNKFLNDIRQVDGILQIVR LD--HLQKL---YTSAKKVPATLTIYDIAGLTRGASKGEGLGNKFLNDIRHVDGIFQVVR LN--HLGQL---YESQKNIPTILNILDIAGLTRNAASGEGLGNKFLSDIRQVDGIFQVVR LT--HYAKL---YQSQKTVPTNLTIWDIAGLVRNASSGAGLGNKFLNDIRQVDGILQIVR LD--HYLKL---YQLSKTVPTNLTIWDIAGLTRNSSTGAGLGNKFLSDIRQVDGVLQVVR LV--HYAKI---YGSQKMVPTNLTIWDIAGLVRNASSGAGLGNKFLNDIRQVDGILQVVR LD--HLQQL---YGSEKKVPTSLTIYDIAGLTRNAASGEGLGNKFLADIRSVDGIFHVVR LD--HYQKL---FGSEKKLSSNLTIWDIAGLTRNASSGAGLGNKFLADIRQVDGIFQVVR LD--HYLQL---FQSQKKISSTLTIYDIAGLTRDASSGKGMGNKFLSEIRSVDGIFHMVR LD--YLKEF---YQSERIIHAPLTLYDIAGLTRGASSGQGLGNKFLNDIRNIDSILHVVR ------------------------------------------------------------ GFKDENITHIEGN-VDPVRDLSVVQDELILKDLEFIDNVREKASRKLR--MLSKNSKEYQ GFENDEITHIEGN-VDPVRDLSLVQDELVLKDLEWLEGARERINKKIN--RSPKNSPEFL GFLKEDITHIEGN-VDPVRDLSVVQDELILKDLEFLENIRERLSKKMR--MVSKNSKEYQ GFAKEDVAHVEGS-VNPTRDLSIVQDELILKDLEYLENAIEKLKKKIS--INKKSSLDYQ GFLKEDITHIEGN-VDPVRDLSVVQDELILKDLEFLENIRERLSKKMR--MVSKNSKEHQ GFLKDDITHIEGN-VDPVRDLSVVQDELILKDLEFLENIRERLDKKMR--MISKNAKEYQ GFLKEDITHIEGN-VDPIRDLSVVQDELILKDLEFLENIRERLDKKMR--MVSKNSKEYQ GFLKEDITHIEGN-VDPVRDLSVVQDELILKDLEFLENIRERLNKKMR--MVSKTSKEYQ -----EITHIEGS-VDPVRDLSVVQDELILKDVEFLEGIREKIGRKMG--RTAKTSMEYR GFRDDSITHIEGS-VDPIRDLSVVQDELVLKDLEWLEAGREKLTRKLG--RTAKSSLDHK GFTKQEITHIEGS-VDPVRDLSVVQDELVLKDLEFLEGIREKLERKMN--RTAKNSGDYQ GFVDDEIVHIEDNKVDPVRDLVIVNDELILKDLEIIESEIERVNKMKNKPGIGG------ GFSKADITHIEGS-VSPTRDLSIVQDELVLKDLEFLEGIREKLERKMS--KTSKTSGEYK GFRDDDIIHIEDNKVDPIRDMNIVTEELILKDLEFIETGIEKVGKLMK-----RPHIDKA GFVNDEIVHIEDNKVDPVRDLVIVNDELILKDLEIIELEIERVNKMKNKPGIGG------ GFVDDEIIHIEENKVDPVRDLVIVQDELILKDLEIIESEIERAKRMLK--KPGDKKSVYE GFVDDEIVHIENNKVDPVRDLVIVNDELILKDLEIIESEIEKVKKLQK-----KPGINAN GFRDDEITHIETT-VDPVRDMTIVTDELILKDLDFIETAIEKAAKTLK-----KPQVDKA GFRDDEIVHIEDNKVDPVRDLMIVNDELILKDLEFIEVGIEKVNKLFK--RPNANKAEIE GFIDDEIIHIEENKVDPLRDIEIVNDELILKDLEYLESAIEQTEKLLK-----KPHSNVS GFKDDEIIHLEKT-VDPIRDLELVNDELILKDLEFLENATERLNKKLK--NRLGPKEDGQ ------------------------------------------------------------ EYNFEIELLGKLEEH-LYDGKRISNFKNEDEKWNVDEIKVLRRNNFLTAKPSLTLLN--- EMHLELRLLEELEAH-MYEGRKLSHFK---QNWTEEEIKILNKHNFLTAKPTLVLLN--- EMKVETELLDALEEH-LFNGKKIRHFK---DHWNLDEVKILNKHNFLTSKPTLILLN--- NSNIEMDLLQRIEEH-LYNGRKIIHFK---KDWTQNEVDILNRYHFLTAKPTLILLN--- EMKIETELLDALEEH-LFNGKKIRHFK---DHWNLDEVKILNKHNFLTSKPTLILLN--- EMKVETELLNALEEH-LFNGKKIRHFK---DHWSLDEVKILNKHNFLTSKPTLILLN--- GMKVEIDLLNALEDH-LFNGKKIRHFK---DHWNLDEVRILNKHNFLTSKPTLILLN--- EMKVEKELLDTLEEH-LFNGKKIRHFK---DHWNLDEVKILNKHNFLTSKPTLILLN--- DLSVELELMNSLEEH-LYEGRKIIHFK---DDWTPQEVSILNRHNFLTAKPSLVLLN--- QMQDELALLAQLEEF-LYEGRRIAHFK---QNWTKEEVDTLGQYNFLTAKPTLVLLN--- QMSTELEMMNALEEH-LYEGKKIAHFK---QNWSEDEVNILNKHNFLTAKPTLVLLN--- SYEINLQTLDKLSTL-LYDGIKVVN-----GDWSDEEVDVINGLNLLTAKPTVYLLN--- NMATELELLSTLEDH-MYEGKKIAHYK---QNWTPEEVEILNKHNFLTAKPTIVLLN--- QVQLEIDTLNRIQDL-LYESRKIST-----GQWTDKEIDIINTYNFLTAKPTVYLLN--- SYEINLQTLDKLSTL-LYEGMKVVN-----GDWSDEEIDVINGLNLLTAKPTVYLLN--- ---YQLQVLDRLSDL-LYEGKKVIN-----GEWDEEEIDVINGLNLLTAKPTVYLLN--- QYDIHLATLDKLSAL-LYDGIKAVN-----GEWTDEEIEVINGWNLLTAKPTVYLLN--- AAQFEIDTLNKLSDL-LYSGKKVVT-----EDWSDREIDVINPLNLLTAKPTVVLLN--- ---LELKTLEKIQDL-LYDGQKVIN-----EPWSAEEIDIINSYNLLTAKPTVYLLN--- KVQFALDTLLKAQDL-LYNAKKISV-----ENWSDEEIEVLNSVNLLTAKPMVYLLN--- LLQREVNFLNELQDH-LYNGKKIIHYK---QNWTTDEISILNTYNFLTAKPTLVLLN--- ------------------------------------------------------------ -----------VSPEEY-LLENAAFSKEVTEWLKEYSPNDD-LIYFSAEYEKNLEYTKNN -----------VAPKDYLL-QENKFLKKIKDWIQEYAPGDE-VMLFSAELETKYNELDNN -----------VSPQDY-IKNENKFIKDILKWVEEFSPGDK-LVLFSAEFESQLIECKDA -----------VSPKDYAL-KNNKYLKDMKEWVEEYSPGDK-IVTMSANFETEFNKYKNG -----------VSPQDY-VRNENKFVRNIIEWINEFSPGDK-FLLFSAEFESQLMECKGI -----------VSPQDY-IKNENKFVKDILKWVNEFSPGDK-LLLLSAEFETHLIESSGT -----------VSPQDY-VTNENKFVKDVLKWVDEFSPGDR-LLLFSAEFESQLIEC--N -----------VSPQDY-VRNENKFVKHIIEWINEFSPGDK-FLLFSAEFESQFIECKGI -----------VSAKDYIL-GQNQFVKPVKDWLNAYSPGDE-LVLFSAEFESAYNELGSN -----------SSPRDYLL-QQNEYLDEVSKWIDQYSPGDE-VLIFSAEYETRYNEFAST -----------VCPEDYLL-QENQFKEKVCKWINEYSPGDE-LLLFSADFETKYNEFMES -----------VSKEDYES-GNNQFYKEVDQWIATNSPNDK-LIMFSAEYETALNNPEES -----------VSPRDY-LAQENEYLRDVQEWVEEFAPDDP-VLMFSAEFEARFNEIMAT -----------VNEKDYVA-QQNEFKQDVEQWIEDNCPNDI-LLMFSASYETKINECKTP -----------VSKEDYET-GNNQFYKEVNEWIVANSPNDK-LIMFSAEYETVLNNTEEL -----------VSEEDYCL-GSNEFYPQVANWINTNCPEDK-VIIFSAQHERMLNEL-EG -----------VSKEDYGK-QENQFYDQVQEWISTNSPNDK-LIMFSAEHETVLNELEEE -----------VSPKDYAD-NGNEFKSAVEQWIEENSPGDK-LLLFSAQYETMLNQLRES -----------VNEEDYKS-QSNEFLSQIQEWMEENSPQDE-LVIFSAQYETKLNESGNL -----------VSENDLRS-GTNEFQPGIEKWIRETCPKDK-LLVFSASFESKIARGEES -----------VNPHEYILKDKTPVIKEVKDWLTENSPGDD-LLPFSGHFETKHNLLKDD ------------------------------------------------------------ DGLAQYCKNVGTDINTSDKRTALPDIILRMKHLLGLISFYTCGPLEVRQWNIRRGNNAQE L--QEFEAFCGKE-KLEVPLTALPNIIIKMRELLQLISFYTCGPIEARQWTIRKGTLAPE L--SEYFDKISIP--DDQLVSAIPRIILEMRNLLNLISFFTCGPQEVHQWNIREGTTAQE NDSDGWKQYCQTLETDLQLQSIMPTLIQNMRQLLDLISFFTCGPQEVREWNIREGLTAQE A--SEYFDKINVS--DQQLVSAIPQIILEMRKLLNLISFFTCGPQEVHQWNIREGTTAQE E--SEYFGKI-RQISDKQLVSAIPQIILEMRKLLNLISFFTCGPQEVHQWNIREGTTAHE GIASEYFDKLKQDTSDQQLISAIPQIILEMRRLLNLISFFTCGPQEVHQWNIRKGTTAQE A--SEYFDRINAS--DVQLVSAIPEIILEMRRLLNLISFFTCGPQEVHQWNIREGTTAQE A--QDLLKHAGLS-QRQLPNSALPQILSKMRESLHLISFFTCGPAESRQWTIREGTTAPE SDWEGLQRYCGGAIKAGALPYALPSIILKMRQLLRLISYYTCGPEESRQWTIQQGTRAPQ GNKQGFHNYCGDSLDTTRFESALPQIILKMREILGLISFYTCGPLEARQWTVREGTFAPQ L---------GTG-------SAIGTVVEEMRSVLSLISFFTCGEMEARQWTIRKGSTAPE DDLESLHEYCNLQASQKVSTSCLPSLILQMRKALGLISFYTCGPLEARQWSIREGSLAPQ E---ELNKFVNKT-------SAKSDIVDKMRSCLNLISFYTCGPKEARQWSIREGSTMPE L---------SKG-------SAIGTVVEEMRLVLSLISFFTCGEMEARQWTIRKGSTAPE EELKEYKEMYPKE-------SVIPLVVEEMRNVLHLISFYTCGPIEARQWTIRKGSTAPE E-LKEYVLDIGRD-------SVIPKVVEEMRSVLSLISFFTCGDIEARQWTIRSGSTAPE GSASEYMAQFNNA------PSAMASIVDAIREVLRLISFYTCGPKEAHQWTIREGSTAPE E------------------DSAIPRIVERMRDALHLISFYTCGPKEARQWTVRVGSTAPE E---------ESS--------SLGAVVQAMRESLNLISFYTCGPKEVRQWTVRKNTIIPD Q--KEFQNYCNNEIDPMLIGSIVPSIIKKTKNLLSLISFYTCGDIEVREWVIRNGTTAAE ------------------------------------------------------------ AAGVIHTDLQETFISADIINYESLRDIE-PPLDESYLKKKGLIKRVGKQYI-MEENDIAL AAGTIHSDLEKTFISANIIKFDDIKKMD-PPLQESQLKSQGKIKRGGKQYV-VEDGDIIH AAGVIHSDLSDTFISADVMKYSDLKTME-PPLNESLLKSKGLIKRAGKQYI-MQDNDVAF AAGVIHTDLQETFISADIIKYSDIKDMN-PPLLESILKQKSLVKKVGKQYI-MHNNDIAL AAGVIHSDLRETFISADVIKYDDLKKME-PPLNESLLKSKGLIKRAGKQYI-MQDNDIAL AAGVIHSDLRDTFISADIIKYDDLKAME-PPLNESLLKSKGLIKRAGKQYI-MQDNDIVL AAGVIHSDLRDTFISADVIKYNDLKTMQ-PPLNESLLKSKGLIKRAGKQYI-MQDNDIAL AAGVIHSDLRDTFISADVIKYDDLKTME-PPLNESLLKSKGLIKRAGKQYI-MHDNDIAL AAGVIHTDLQKTFINASVIKYE-------------------------------------- AAGVIHSDLEKTFINASVIKYDDLRDAS-HPIDESALRRLGKIKRCGKDYV-VEDGDVVH AAGVIHTDLEKTFISASVIKYADLESMA-PPLQESTLKSQGKIKRGGKQYT-IEDGDVVL AAGLIHTDLQKTFINSIVYKWDDLKQLD--TFDESKLKSQGKQHKCGKKYI-VEEGDVLI AAGVIHTDLEKTFISTNVTKFADLEKMV-PPLKESQLKAQALVKRGGKQYV-MEDGDVVL AAGLIHTDLQKTFISAQVYKFDDLVNLS-PPFNEASLKNSGKQFKCGKNYI-VQDGDVVI AAGLIHTDLQKTFINSIVYKWDDLKELD--TFDESKLKSQGKQHKCGKKYI-VEEGDVLV AAGLIHTDLQKTFINAMVYKWQDLSKLQ--ALDETKLKASGKQHREGKKYI-VEDGDVLL AAGLIHTDLQKTFINSIVYKWDDLKEVS--EFDENKLKSQGKQHKCGKKYE-VEEGDVLI AAGAIHTDLQKTFVSAQVYKWADLEQES-APLNESSLKSKGKQYRHGKTYV-VEDGDVLV AAGVIHTDLQKTFISALVYKWDDLKSEK-APFNEAGLKSSGKQHRHGKKYA-VEDGDVLL AAGVIHTDLKTTFITAQVYKYDDLRLEE-APLNESKLKASGKQLRVGKSYV-VEDGDVLL AAGVIHTDLQKTFINAEVINYNSLIESGSKNIKESNLKSKGLIKRVGKKHI-MEDNDIVL ------------------------------------------------------------ FK--AAGGKTRMVQRLSLMATIADDDFPLFKTSINILTGSPAVVYANLMVVWKPNPNYEV FK--ATSGKK-MVQQLALFSAIEDESYPLSVETLTILSSNRPRLFANFNKIYKPNPSLQI FK--AAGGKTRMVQQLSLFGSINDDGYDLLISTLTTISGNPPLLYNSLCTIWKPNPSYDV FK--AVKGKTRMVQQLSLFGSINDDSYDLFVSTITTLSGTPPILFSKLSTNWKPNPQYDI FK--AAGGKIKMVQQLSLFGSIGDDGYDLLISTLTTISGNPPLLYNSLCTVWKPNPSYDV FK--AAGGKTK--MMVCDF---------ININAGSNIGYSPAIYTKAYGMVGNQNLSYEV FK--AAGAKLKMVQQLSLFGSIDDDGYDLLISTLTTISGNPPLLYNSLCTVWKPNSSYDV FK--AAGGKNKMVQQLSLFGSIGDDGYDLLISTLTTISGNPPLLYNNLCTIWKPNPSYDV ------------------------------------------------------------ FR--AAAGKN-MVQQLSLYSVIDEGSFDLLIATISALSGRSPVLFANYNHVAHPNPNYAI FK--AAGGNIRMVQQLSLHSAIDDNSYELAVSTLSSLAGNPPVLFSNFTAMCKPNPTYII IK--AGSGKARMVHQLSLVSSIPHNKYLQTISTLQALTGIQPESISTYTLLAKPSYAFKP FK--AAGGSTRMVLQLSLVSAIDDESYDLCVSTLSSLSGNPPILFGNFTAMLKPNPAFDI IK--AGNAKARMVHQLSLVSMVSHSNYVQTISTLQALTGLTPQPISTYTLVTKPHDVFKP IK--AGSGKARMVHQLSLVSSIPHNKYLQTISTLQALTGILPESISTYTLLAKPSYAFKP IK--AAGGNARMVHQLFLVSSIPHANYLQAVATLQAITGLEPQEISTYTLITKPNHVFKP IK--AGSGKARMVHQLSLVSSIPHNKYLQTISTLQALTGSQPQSISTYTLLTKPSYAFKP IK--AAGGKSRMGTQLLLCASIPHSKYVQTVSTLEALTGLRPQEISTYTLLTKPHNVFKP VK--AAGGKTRMVHQLSLVSSIAHGSYVQTVLTLQAFTGLSPQPIATYTLLTKPHEVFKP IK--AAKGNNRMVHQLSLVSTVEHGYYVQTVATLKALTGQSTQNIATYNLVTKPHDVFKP FK--STASKK-MVQQLSLFGSIDDGSFELFITAVNTLSGNPPVLFSNITSVWNPNPSYDI ------------MQQISLYAKISNSQLKICLHALASLTGMDPITILQHTMVWAPAQKYTP DNLNSKNELVEPTRMTTATSIPLELDSDEILNTMKEQEFPIKQEQLFINNPSNN------ EKVNAKNQLVEQTRVKLSTAVPLSKLNYHFMEKLSNDDIESFNVKSYIQDIDSNN----- ENVNSRNQLVEPNRIKLSKELPFSYLNFKILKSFTSDEIPMTQNILHNSTDGSKNDGENV EGTNAKNQLVEPNRINLHRELTLDQFDYNILKKINQDHAPFDLTLLDKILKECNTNGDDK ENVNSRNQLVEPNRIKLSKEVPFSYLNFRILKSFTNDKIPMTRNILHNSTNEDQNNSKHT ENVISRNQWVSRNRIKFTKELPFSYLNFKFLKSFPTDTFSMTRNILHSTTTEIKNGSEHA ENVNFRNQLVEPNRIKLSKEVPFSYLNFKLLKSFTKDNISMTRNILHSNNNDEEKSGSEQ ENVNARNQLVEPNRIKLSKEVPFSYLNFKLLKSFANDKIPMTQNILHNSTNGAVNNNERA ------------------------------------------------------------ EKVNAKNQLVEQTRVQLMQEIPFEKYSYKLCTKMTGDGPPIETEYLNCGDG--------- EKVNSKNQLVEQNRIRLCKEVPMELLNHSLLKEYTDDNLGIDPRYFRYGEEQDNMDIDDG KFEPGKVNQIEQYYMRCITTWNSDKKGFDISEPFINKESNIVVRKLFTEEDSV------- EQVNSKNQLIEQNRIKLCTSLPLEKQNYKVLKQFRGDQINLLQDMLNSSSDPDAMDVDSE KFEPGKVNQIEQFYMRCVTTWNDETNKFDLASPVLENDTDILVNRLFLGVDD-------- KFEPGKVNQIEQYYMRCVTTWNSDKKEFDILEPFINKESNIIVRKLFCEEDNV------- QVKAGKINQIEQHYMKCITTWQD--YPFDISLPVIESKLDITAKKLFEEDDDAEKKRQRE KFEPGKVNQIEQYYMRCVSTWTGQNNDIDISEPIITGESNIIVRKLFSGDDNQI------ KFEPGKVNQIEQYYMKCTTIWNDEASHFDLSQPVTEDTQ-ILVQQLFTGEE--------- KFEPGKVNQIEQYYMKCITTWSDG-SEFDLASAVIKENGSVFLGRLFHAEDESV------ KVEAGKVNQIEQYYMKCITTWDEDT--GDIEKPILKDSNTVEASRLFVGDNN-------- DRVNSKNQLVEPNRIRLLRALPLELLDYTLLKKLSSDGLPISPDVIRDSEMEVDLKGITV KILPGQGGQLDQYRIHVTNDNKNE-DKEKIISYVQSKDSKEDIHNLA------------- -TINWTLTTADIPAAGSNRKVSMQAIQEATIVHNNPTLANVMAELGYSFDYMYVTVGVRF -KTNWAFQISDIPAAGNNRKLSSQTIHESVIQSSSGSVSSFIDELGYVNDFQYINVGVKF SCSSWSLQISDIPAAGNNRSVSMQTIAETIILSENSSISSLMNGLGYVFEFQYLTIGVKF KHKSWVFSMSDIPATGNNRKVSVQTIYESLITSIDSSITKFMNELAYVYEYSYITVGVKF SCSPWSLQISDIPAAGNNRSVSMQTIAETIILSKNSSVSSLMNGLGYVFEFQYLTIGVKF SCSPWSLQISDIPAAGNNRSVSMQTIAETIILSENPSISSLMSGFGYVFEYQYLTIGVKF SCSPWSLQISDIPAAGNNRSVSMQTIAETIILSKDSSISSLMSGLGYVFEFQYLTIGVKF SCSAWSLQISDIPAAGNNRSVSMQTIAETIVLSKNSSISSLMNGLGYVFEFQYLTIGVKF ------------------------------------------------------------ -TRPWSLSLWDIPSAGKDRKVCTQAVVESVVTSAHSSILSFLAELGYVPGYQFVQLGTQF ETYSWSLSTSDIPSAGGNRKISMQSITESVILSSSSSIASFLLELGYVIEYQYFTLGVRF -ERVWTLQVSDIPVAGKNQGCCQQQIYESTLVHRKDSFLIFLSDLGYEVINQYWQKGVRF PAKCWTLSISDIPTAGSGRKVSTQAMTETTILASSPSIVSFLAELGYVLDFQLVTLGVKF -RRNWTMQISDIPIAGKNQACSAQTIYESTLVHRRDSFLQFLEDLGYDVINQFWMKGVRF -ERVWTLQISDIPVAGKNQGCCQQQIYESTLVHRKDSFLMFLSDLGYEVVNQYWQKGVRF REKVWTLQIGDIPIAGKNQVCLQQTIYSSTLVHRNDSFLVFLNDLGYSVINQYWVKGVRF -ERVWTLQISDIPIAGKNQGCSQQQIYESTLVHRKDSFLVFLSDLGYEVINQYWLKGIRF -VKHWTFQISDLPNAGKN-TVSVHNYHESTLVHHKDSFLQFLEALGYDVVNQYWIKGIRF -QRIWTLQISDIPIAGKNQACSAQTIYESTLIHHKDSFLQFLEDLGYETISQYWIKGIRF -KRIWTLQISDIPVAGKNQTCSAQTIYDSTLVHRNDSFLQFLSDLGYDVINQFWLKGVRF ENSSWALHISDIPAAGTNRKVLLIN----------------------------------F -NRQWHFQIMEMPEAGKQKT-TSQSISSWSV--KKGDSFQFLQSLAYKFQYEYWQKGFQF VHRDVIIHCHKVWDIAEDN----IIQVTKGGYVVHTFVTVNRATDIERLNLAEANLLSLQ QFSGVVMEIYKVWQVVQKDQEVSMKLITKDGFMIKAMYNVNKSTDIESLNNGSQLLLKLK FMHGLILELQKIWQIEENG----NSQITNGGFLIKAYINVSRGTDIDRINYTETVLMSLK YLHELLIEVCKIWNIISDGQVSTSSQVTSGGYLIKAYVDVNKSTDIDRINYAENILVNLQ FMHGLILELQKIWQIEEAG----NSQITSGGFLLKAYINVSRGTDIDRINYTETALMNLK FMHGLILELQKIWQIQEAG----NSQITNGGFLIKAYINVNRGTDIDRINYTETVLMNLK FMHGLILELQKIWQIEEAE----NSQITSGGFLIKAYINVSRGTDIDRINYTETVLLNLK FMHGLILELQKIWQIEEAE----NLQITSGGFLIKAYINVSRGTDIDRINYTETVLMNLK ------------------------------------------------------------ YLNGIVFQISKLW--ALHGESGKTSAVTKDGFLIKAYLNVPKATDLESINQGTAHLQQLK YFNGICLDLYKIWHLKEDT----TSQITKGGFLIKAYVNVAKSIDLENINNGISSLLGLQ FYGDIIIEIYKIFQADSNEGIKLKLLDDSNQFQIKAYININKSTEIDSINSGVKELIKLQ NMNGAFFELSKIWRLTESG----TEQITKSGFLAKAYVNVARSTDIKNINQGTASLLSIQ FHGDIVIEIFKVFKDAEKDKIRLKLLDPSNTFQIRTYINVPKSTDVELINQGTKDLLKLQ FYGDIIIEIYKIFQADSNEGIKLKLLDDSNQFQIKAYININKSTEIDSINLGVKELIKLQ FYGDIVIELFKLFKDNLDG-IKLKLLDESNTFQIKCYINVSKSTDIDQINQGVKDLAHLK FYGDIIIEIYKIFHVSTNG-IKLKLLDESNQFQIKTYININKSTEIDLINSGVKELIKLQ FYGDIVIEIFKVFEPAVNSRLKLKLLDSSNTFQIKTYLNFPKGASVDLLTQGTKDLAKLK FHGDIVIEIFKVLEPKEEGKIALKLLDESNTFQIRTYINIAKSTDIDLINQGTKELLRLQ FHGDIVIEIFKVFRQSSDNAIALKLLDESNTFQFKAYINVPKATDVDAINQGTKELLKLQ ------LTFKKFWNITNND----NILVTEGGYLLKAYVNVGKITDIDRINHAESSLLALQ VYGNAVIQLTRI-HILDQTTKNIKLLDPSKQWLVKVYIDVGHLTDIEALNKAVKELEKVK RDLSGYLDFKVPDRKSMDSRLTQKKSAAKKAREAAAKTQG--EVPEQKISEEVEAPLDAN TDLRDYIELDIPDRKCMDTRLNHKKSAAKKAREAIKKQESVAGKNTEVISVKTGSKHDVT KELQGYIDLSVPDRQSMDSRVAHKKSATKRAREQEKKQAGVTAIVNSSEHAT-AVKPAVE KELQGYVDLITPDRKSMDSRLGYKKSATKKAKEAAKREASHS----------VPAPIEQK KELQGYIELSVPDRQSMDSRVAHKKSAAKRAREQAKKEAAVPATIKTSETSATTVKPAIE KELQGYIELSVPDRQSMDSRVAHKKSAAKRAREQTRKEAAVNATAKTSENSAVAVKFTVE KELQGYIELSVPDRQSMDPRVAHKKSAAKRAREQANKEASVTAIKKTTENISTAVEPAIE KELQGYIELSVPDRQSMDSRVAHKKSAAKRAREEAKKEAGVAATEKTSENPFTTVKPSIE ------------------------------------------------------------ RELRDYLELSIPDRKSMDSRVGHKKSAAKKAKEAAKKAE-------------LEAQAAVI RELNGYIDLEVPDRKVMDSRVDHKKSAAKRAKEATKKATTDENSTSNKTVPEPKNELTIN EFLKNLFVLEIPDRMFMDSRIKQKKSAAKKAREAAAAAAATANAKDIKFEKPSLQKLPQN KDLSGYIDLEIPDRKAMDSRLENKKSAAKKAKEAAKKEVSAQQLVAATKSQPSQDRIGAG EFLKNLIKLEIPDRMFMDSRVTYKKSATKRAKEALENDTSEA----------IATKESLP EFLKNLFVLEIPDRMFMDSRIKQKKSAAKKAREAAAAAATATNSKSLTSNNEHAKDIKIE DFLKGLFVLEIPDRMYLDSRVSNKKSAAKKAKEAAAAAATSTSNDSIALTTSGTTHPARE DALKNLFVLEIPDRMYMDSRVRQKKSAAKKAREAAAKQANELDEPKVEEVEEIKKAKDEK ESLANLFELEVPDRMFMDTRVARKKSAAKKAREEAQKAAVLDPQPSTTVQKDSKRAFEET EFLKNLFKLEIPDRMFMDSRVQVKKSAAKRAREAAVVKEVQENGSSKQETKETAK---PE DFLKNLVKLEIPDRIHMDSRVSKKKSAAKRAKEEAEK-----KTLESNENKEVQSSSKDE KELQGFVELVIPDRRSMDSRPDYKKSAAKKAREAASKN----DQAIVPKDEDVKIKQVVN TELHGLMNLEIPDRNAFDTRIR-KKSAAKKAAKITPMDSDSEEEAAFTINEDYARRFQYN DEH-----EDASDESSSEEEDDYGELLTEEVEDGIKNVLTAIRNNEKKLLNPEVKFFEDP ASKEVPAEDDDEDSSTSEEEDDYGELITEEVEEGIQKVLDAIKNNETKLLNPGVKFFEEP PKEPYAPSEEEDDEEEEEEEDDYGELITDEVEKGINQVLDAIKNNKTKLLDPKVKFFEDP KPKPTSKISDDIESESSEDEDDYGELVTEEVEDGINKVISAIRNNETKLLDPEVKFFEDP ASKSYVPSDEEEDEEEEEEEDDYGELITDEVENGINQVLDAIKNNKTKLLDPKVKFFEDP TREPYIPSDEEQEDEEEEEEDDYGELITDEVEKGINQVLDAIKNNKTKLLDPKVKFFEDP PREPYASSEEEEEEEEEEEEDDYGELITDEVENGINQVLDAIKNNKTKLLDPKVKFFEDP PRKPYIPSDEEEDDEEEEEEDDYGELITDEVENGINQVLDAIKNNKTKLLDPKVKFFEDP ------------------------------------------------------------ EDVPEENHTASDEESTSEEEDDYGELITEDVEEGIKNVLEAIRTKDTELLNPTVRFFEEP EKVND---DSEESSSSEEEEDDYGELVTEEVEEGIKNVLQAIKRNDKKLLNPNVRFFEDP KKTLSPSKDSDESSSSSEEEDEYGDLITEDVETGINQVLQTIKTDPSKLLDPNVKFFEDP KESHSFESEDDEDDISSEEEDDYGELVTEEVEDGIKEVLTAIKNNDKKLFDPSVRFFEDP EKKKQIQEYDEEESSSSEEEDEYGNLITNNVQEGINKILSTLKSDPKKLLDPEVKFFEDP KPSLQKLPDAYSSSSSSEEEDEFGDLITEDVETGINQVLQTIKTNPSKLLDPNVKFFEDP KLIQESQKDLENSSSSDEEEDEYGDLITEDVEQGINQVMEIIKKNPSKLLDPSVKFFDDP PKQKEVEEDDEPESSSSEEEDEFGDLITEDVETGINKVLETIRTDPSKLLDPEVKFFEDP PIA-----EENESLTSSEEEDEYGEMLTEKVEASIEKVIKTLKTDPKKLLDPNIKFFNDD EKKVSFSDSESESESSSEDEDELGDLITEDVEAGINNVLQAIKENPTKLLDPNVKFFEDP NRVQIVDNSESEDESSSEEEDEYGELITEDVEQGINKVLEAIRSDPKRLLDEKVKFFENI DQVGNLS-DSGSESSSSEEEDDFGELITEDVEEGIQNVLQAIRNNDTLLLNPEVKFFDDP KEREEKVRDDDESDSTSEDEDDNADLATEEVDAAIANVIATIRNNPGKLLEKNVKFFDEI EKAKMEVSEKHKPVYLKDYHRMNILSGNALKDDDELETVSFVSQQREERQQLLNEINNAF EKAKLAKTEKHKPVYLKDYHRMNLLNGNVNADDDEFETVSFASHQREERNQLLSEIKDAF ESAKLANREKHRPIYLKDYHRMNILSGDALKDDEEQGTVSFVSQQREEKSQLLDEIKNAF EKAKLAKTEKHKPIYLKDYHRMNILSGNPIADEDEQETVSYVSQEKEERTQLLDEIKNAF ESAKLANREKHKPIYLKDYHRMNILSGDALKEDDEHATVSFVSQQREEKTQLLNEIKSAF ESAKLANREKHKPIFLKDYHRMNILSGDALKEDDEHATISFVSQQLEEKTQLLNEIKDAF ESAKLVNREKHKPIYLKDYHRMNILSGDALRGDDEHATVSFVSQQREEKSQLLDEIKNAF ESANVANHEKHKPIYLKDYHRMNILSGNALKEDDEHATVSFVSQQREEKTQLLNEIKNAF ------------------------------------------------------------ EAAKLAQAERHKPIYLKDYHRMNLLAGETFAKDGEFETMSFAAEQRQERAQILAEINEEV EKAKMERSETEKPIYLKDYHRMNMLSGKALEDDEDMQTVSYASQQKEEKARLLDEIEGAF ESIEYNETTKHKPLYITDYNRMQLLEGEKHHEDEEQKTISFVTVQKEEKDQLLAEIKKAF EKAKIAKTSKEKPVYLKDYHRMNILSGETFKDDEDMATVSFASQQKEEKAQILGEIKSQF DNEGSQARKKEAPIYLKDYHRMNLLSGNYKDDDENFETVPFAVTQREERNQLISDIKNQF ELIEYNETTKHKPLYISDYNRMQLLDGKQTNEQEEQKTISFVTVQKEEKDQLLAEIKKAF ETANVAGGKLEKPMYLKDYHRQMLLDGSYKEFDEG-ETVSFAAEQKEEREKLLSDIKSAF EKVEYSARKKHKPLYISDYNRMNLLDGGYKEFDEK-ETVSFAAVQKEEKDQILAEIKNAF DEDTNATSEKEKPMYLKDYHRMNLLSGAFKEEDDAFETVPFVVTEREERNQLLNDIKNAF EN-FTETATKEKPLYLKDYHRQNLLSGGYKDEDEDYGTIPFVVTQREERDQLLADIKSAF E--QNGTTEKEKPMYLKDYHRMNLLSGGYKGADEDYGTVPFVVAEREERNQLLSDIKNAV DNASVLL--KKVSQFTKDYHRMNLLAGETFQDDEDFNTVSYVEQQKEEKQQLLSEIKNAF KEGEIPTAKKEKPMYLKDYHRQTILDGGLTAEGEF---PPYAIQQEEDRAKLISEMHADN DGDDQKEDDDFLKKKEKKMEVSKTDEIDPNKDEDKFLEEFVNQHAWIPKKGDKIISLDGE NGDDDAEEEDFLKKKEPQNKRESEVLPNPKVDDEKFLEEFVNQQAWIPKKGDKVINLDRE NDEDNEDEDDFLKKKAPSTKKEERNLPDPTVNEENFLEEFVNQQAWIPKKGDKVISLDLE GNDEDKDDDDFLKKKEPST-VEGTTLPNP-KDEEKFLDEFVSQQAWIPRKGDKVLNVDGE SDEENEDEDDFLKKKEPSTKKEGKNLPDPTVNEENFLEEFVNQQAWIPKKGDKVISLDLE GDEDNEDEDDFLKKKEPSTRQEEKNLPDPTANEENFLEEFVNQQAWIPKKGDKVISLDLE SDDNNEDEDDFLKRKEPSTKKEEKGLPDPSGNEENFLEEFVNQQAWIPKKGDKVISLDLE NDEDNEEDDDFLKKKEPSTKKEGKSLPDPTVNEEDFLEEFVNQQAWIPKKGDKVISLDLE ------------------------------------------------------------ GKAEEDDEDEFLTKRSQASEVAQKTLPDPSVDDEQFLQAFVEQQAWIPRKGDKTVDLDRE NADEDEDEEGFLTKKEPTERERRTALPDPQVDDEKFLEEFIDQQAWIPKKGDKMIDLDRE DEDVEDNDDDFFRKKEGKRSKNEEDLPDPNQDQQGFLNAFLDSKAWIPKKGDKIINLDKT KSVDGEEEEDFLIKKAPSKAQKVSDLPDPAVDDEKFLEQFVSKHAWVPKEGDKVLNLDGE DNDDENDDDDFLTKKEHVRSRNFDGLPDPEVNQDGFLSAFIDKQAWIPKKNDKVIDLDKE DEDIEDEQDDFFRKKDEKQFKNEAELPDPNQDQQGFLNAFLDLKAWIPKKGDKIINLDKT NEANEDEDDDFLKKKDANKSLEESSLPDPEKDQQGFLSAFLDQKAWIPTKGDKVLNLDQD NEEMEEDDDDFLKKKEPKEKKKEEELPDPQKDQQGFLSAFLDQQAWIPKKGDKVINLDRE NDDGEENNDDFLKKKEHPTKVEDKALPDPSDNPDAFLSAFLDNQAWIPKKNDKVINLDQE NEEEDEDDDDFLKKKEEAANHIHPDLPDPNENEQGFLEAFVNDRAWIPKKNDKVINLDRN EDGSDDDDDDFLVKKGNKE-DDEEDLPDASNQEE-FLKSFFDQQAWIPRKKDKVINLDKQ DEEVSDEEDDFLQKKEPSESTKDKRLPNPEIDEEKFLDAFVSQNSWIPKKGDKMMAGDGE DDEEDEDGEDFLTKRKEQREIEEVELPDPEKDGDGFLDKFVSSKAWMTKDDNTYNELVED DDEEDDAVEQFENAYNFRYEDPNAAEIVSYARTQATLRRSKTSSRRRKREEEKSHKEEEK EDEDDDAVEQFENAYNFRYEDPNAAEIVSYARTQATLRRSATSSRRRKRDEEKAIKDKEE EDEEEDAVEKFENAYNFRYEDPNAAEIVSYARTQATLRRSDNTSRRRKRDDEKKTKENVK DDDEEDAVEKFENAYNFRYEDPNAAEIVSYARTQATLRRSATSARRRKRDDEKQVKQEVK DDEEEDAAEKFENAYNFRYEDPNAAEIISYARSQATLRRSDDSSRRRKREEKRKIKEQIK DDEEEDAVEKFENAYNFRYEDPNAAEIVSYARSQATLRRSDNSSRRRKREDEKNDKEQVK DDEEEDAAEKFENAYNFRYEDPNAAEIVSYARSQATLRRSDNSSRRRKREEEKKVKEQVK DDEEEDAAEKFENAYNFRYEDPNAAEIVSYARSQATLRRSDNSSRRRKREEERKIKEQVK ------------------------------------------------------------ DDKEEDAVEQFETAYNFRYEDPNAAEIVSYARTQATIRRSAASTRKRKRDEEKQEKDKDR DDEEDAAVEKFEHAYNFRYEDPNAAEIVSYARNQATLRRSATSSRRRKRDEEKKEIERTK DEEEDDAVEKFENAYNFRYEDPNGGAIISYARNQATLRRSKTNSRKRQREKRQELKRQEN DEEEEDAVEQFENAYNFRYEDPNAAEIVSYARNQATLRRSGSNTRRRKREEEKEAKNSEK DDEQDQAVEDFERAYNFRYEDPNSAEIVSYARNQATLRRSATNSRKRQRDKKNDEREKEE YEEEDEAVEKFENAYNFRYEDPNGGSIISYARNQATLRRLKTNLRKRQREKRQELKRQED DEEEDDAAEQFETAYNFRYEDPNSTEIISYARNQASLRRSKTNARKRARDKEHEEKRKEE DEEDDNAVEDFENAYNFRYEDPNSAEIVSYARNQATLRRSKTNSRKRQREKKQELKRQEE DEQDDDAVEDFEKAYNFRYEDPNSAEIVSYARNQATLRRGKTNSRKRAREKKHAIKEQEI DEEDDDAVEKFEHAYNFRYEDANSAEIVSYARNQATIRRSATNSRKRQREKQQEVKEQEN DEEEDEAVEKVEHAYNFRYEEENSAEILSYARSQATLRRSKTNSRKRQREKRQEERAQEE DDEDEDAAEKFEHAYNFRYEDPNSAEIVSYARNQATLRRAESSSRRRKRTEEKEQKTIVK EEDEDEKADEFEQEYNFRFQEEDGKEIISYGRNQDTVRRTAENSRKRQRESKAERKAEEK KEKEEKIQKKKVKKVNKVTDILTQIKKEYGISEEMVEKITSTLMNNDYKEDEWDNVVAEL EEKQKAVQKKKKEKVNQLTDVLEQVKKEYGIKEEHVKALTDTLINGNFEDGKWDEVIGTI VEKETAIQKKKTKKLNKLTDILGQLTKEYGISADMVKKITDTLMKNDFKEEEWDNVVAEL KEKEQKVQKKKTKKVNQLTDILEQLKKEYGISESMVKKITDTLLNNDFKDDEWDKVVAEL AEKETALQKKKTKKLNKLTDILEQLTKEYGINADMVKKITDTLLKNDFKEEEWDNVVAEL AGKEMAVQKKKTKKLNKLTDILEQLTKEYGIDSDMVKKITNTLMKNDFKEEEWDNVVAEL TEKDKAVQKKKTKKLNKLTDILEQLTKEYGINADMVKKITDTLMKNDFKEEEWDNVVAEL VEKETAVQKKKTKKLNKLTDILEQLTKEYGINADMVKKITDTLMKNDFKEEEWDNVVAEL ------------------------------------------------------------ QEREKAIQKKKKETVYQLSDVLDKIRKEYGISEPMVQKLTATLLNGSYDDSKWDEVVGEL QEKELQVQKKKKEKVNKLTDVLNQVKKEYGINESLVKKLSDTLLNGDFEDGQWDNVLGEI EIVQDLLKKKKTATVNKVMDRLSKIKQAIGVDDKTIERVFDSLLNDDFDDADWDNKMAEI REKETAIQKKKTEKVNKLTDVLEQIRKEYGINEEMVQKITGALLNGDFKDDQWDAVVSEL EKKQELLKKKKTAKLNKVMDRLEKIKQAVGVDDEVIKKVFESLLGDDFDDADWDSKMAEI EIIQDLLKKKKTAKINKVVDRLSKIKQAIGVDDETIERVFDSLLNDDFDDADWDNKMAEI EKKEELLKKKKTAKLNKVIDRLAKIKEAVGVPDEVIQRVFESLLNDDFDDADWDNKMAQI EIVQNMLKKKKTSKVNKVLDRLTKIKEAVGVSDETIERVFDALLQDDFDDADWDSKMAEI HEKEQAVQKKKTAKLNKVIDRLSKIKEAVGVSDEVIEKVFDSLLNDDFDDTDWDSKMAEI NEKEALLKKKKTTKLNKVMDRLQKIKEAVGMKDEVIEKVFDSLLKEDFDDADWDNKMAEI AEKQEELKKRKIAKANKVMDRLAQIKEAVGVSDEVIEKVFDSLLKDDFDDAEWDNKMAEI EKKEKAIQKKKTEKVNKITDVLDQLKKEYGINGSMVQKITDSLLNNDFKDDEWDNVVSEL REREADKARFKKLMVKDVVKKMEALKKHIGDDASKFTAED---FEGDFDDTEWDRRMQQV FNEEFYAQEGKPEWDEDDEIMADFYKEGNDGQEPPELDTNDTRSKKKSKIEEKKSKKKEK FNDEFYNQEDKPTWDENDDIMGEFYAE-QETEDHAEDDETLAKKSKKDKIQEKRDKKKDK FNEEFYEQEGKPTWDENDEIMGDFYADGDEEDKEEDKGEQEQPKRKKNKKEEKLQKKREK FNEEFYDQEAKPTWNDEDEIMADFYDEQDAKLEDDELLEEEEKKSKKNKSEDKKAKKKEK FNEEFYQQEGKPTWNEDDEIMGDFYADADDQTEEGEVEKEQKPKRKKSKKEEKLQKKKEK FNEEFYQQEGKPTWDENDEIMGDFYADGEDKVQKSEEAENDEPKRKKSKKEEKLQKKREK FNEEFYKQEGKPTWNEDDEIMGDFYADGDDQGEEGIVEEDENPKRKKSKKVEKIQKKREK FNEEFYQQEGKPTWNEDDEIMGDFYADGDVEGEEDEVQKEQKPKRKKSKKEEKLQKKREK ------------------------------------------------------------ FDEEFYQQEGKPTWDENDEIMGDFYAGNDDDAAPTEDHANGEKKSKKEGTKEKKAKKQEK FNDQFYEQEGKLTWDENDEIMGDFYQEQDAESNQERAEEDEEKKSKKEKINEKKSKKSEK FNEQYYEAELKPTWDDDDEIMGDINSDEEEEQEEEEEEKEEDKKSRKDLLKAKKSAKKEK FNEEYYNQEAKPTWDEDDEIMGDFYREEQGESRDSDIDEEPVKKSRKEHKKEKLSKKKDK FNEQYYNAELKPEWDEDDEIMSDFNNQKDEDGSDYQDKESVEKKSKKEKLKDKKAVKKEK FNEQYYEAELKPTWDDDDEIMGDINSDEEEEEGEVASNSESEKKSKKDLLKAKKSIKKEK FDEQYYGAEVKPQWDDE--IMDGFKPEGEEEEEEDDNEEKQGKKSKKEQLKEKKLAKKEK FNEQYYNAEIKPTWDDD--IMDDFNQGNDLEDADAEEYSAQQKKTKKEILKEKKSAKKEK FNEQYYSSEIKPEWDENDEIMADFHASKDAGVSGGDEVDGGEKKSKKEKLKEKKLAKKEK FNEQYYGDENKPVWDEDDEIMADFHKGDDNDEDDGPEVDEEEKKSKKDKLKEKKSVKKDK FNEQYYGSELKPEWDEDDEIMAEYHENEEEEEEEDESPESKVKKHKKDKKSDKKKAKQEK FNEEFYNQEGKPTWDDDDEIMSGFVDGEEDNEQDSDLEDVEPKISRKEKKSEKKSEKQKK FNDEFYGDDDKPTWDDDGGI--------EVEESDDDDEEEEELSNRKQKQLEKQQKKKEA KQLQEMVETAIEKNKAIIDEVEEERGRSFRYREVSPESFGLSTREILAADDTDLNEFIGL KQLHEMVEKAVDERKDIIEQVEEERGRSFRYREVSPESFGLTTREIFTADDADLNEFIGL RKLNELVENALEQNKALIEEVEKERSSTFRYREVSPESFGLTTREIFAADDTDLNEFIGL KKLSELVESAVEQNKAILDEVEKERLRSFRYREVSPESFGLTAREIFAADDTDLNEFIGL RKVNELVENALEQNKALIEEVEKERSRTFRYREVSPESFGLTAREIFAADDTDLNEFIGL RKLNELVENALEQNKALIEEVEKERSSTFRYREVSPESFGLTAKEIFAADDTDLNEFIGL RKVNELVENALEQNKALIEEVEKERSRTFRYREVSPESFGLTAREIFAADDTDLNEFIGL RKVNELVENALEQNKALIEEVEKERTRTFRYREVSPESFGLTAREIFAADDTDLNEFIGL ------------------------------------------------------------ KELRNIIEESVEQNKALIEKVEEERGRTFRYREVSPESFGLTTREIFMADDAALNEYIGL RHISELAEKVVEENKAIIEEVEEERARTFRYREVSPESFGLSTREIFAADDTDLNEFIGL QSLKEKAQAIVEANTKLMDEIEEERGRQFKYREVSPETFGLTTRDIILADDKQLNNFISI KKVAELVENAIESNKALVDEVEEERSREFRYREVSPESFGLTHREIFEAADTDLNEFIGL ESLKEKAQEIVEANKKIIDEVEEERGRSFKYREVSPETFGLTTRDILLADDKQLNNFIGL QSLKEKAQAIVEANTKLMDEIEEERGRQFKYREVSPETFGLTTRDIILADDKQLNNFISI EALKLKAQEIIDANTKIKEEIEEERGRSFKYREVSPETFGLTTRDILLADDTQLNSYIGI EALKEKAQAIVEANTKIRDEVEEERGRQFKYREVSPEAFGLTTRDILLADDKQLNNFIGI KSIKEKAEQIVEANKKIVEEVEEERGRLFKYREVSPESFGLSTREILLADDQDLNKFISI ELLRVKAQEIVEANTVLIDEVEEERGRSFKYREVSPESFGLTTREILLADDKQLNTFIGI KTLKEKALSIVESNAQILDEIEEERGRSFKYREVSPETFGLTTRDILVADDSQLNNYIGL KKLTEMVENAVEQNKNIIDEVEKERARTFRYREVSPESFGLTTREIFTADDTDLNQYIGL KEILEKATAFVEENVDLAIEKEEARGRKFRYREVSPESYGLTANDILMADDKQLNEYVGL KKFAPYRPKELRAKDKRKVTKSRRLREWKKKVFNNESGKKSHDKDKKNKNSHKKN----- KKFAPYRPKELTSKDRRKVTKSRRLREWRKKVFNTEEGHQTSKEKERLKNKKRKR----- KKFAPYRAKELRAKDKRKVTKARRLRDWRKKTFKNENGDLKGKHKQRHNHKHKSH----- KKFAPYRPKELRAKDKRKVTKSRRLRDWRKKVFNNEAGKSKHKHGHQHRHEKKRH----- KKFAPYRSKELRAKDKRKVMKARRLREWRKKTFKNENGASKSKHKRGHSHKHKGH----- KKFAPYRARELRAKDKRKVTKARRLREWRKKTFKNENGDPKSKHMKKHNHRHKSN----- KKFAPYRAKELRAKDKRKVMKARRLRDWRKKTFKNESGDTKSKHKKKHSHKHKGH----- KKFAPYRAKELRAKDKRKVMKARRLREWRKKTFKSEKGDSKSKHKKKHSHKHKSH----- ------------------------------------------------------------ KKFAPYRAKELRNKDKRKVMKAKRLKEWRKKVFNNENGTQAAPKKEKSRSKHKTS----- KKFAPYRPKELRAKDKRKVMKSRRVRDWKKKVFKNENGGAHLEKSDKEHKKKRKH----- KKFAPYRPKELRLKDKRKYTKKKHLQEWKKETFKNL--KSKSKSKTKSKTKTKKH----- KKFAPYRAKELRAKDRRKVTKSKRVREWKKKVFGKEEGDSGSSKKSTKKTKSKPD----- KKFAPYRPKELRLKDKRKYTKKRHLQDWRKEVFHDRSGDMHHKHKVHKKDKKDKK----- KKFAPYRPKELRLKDKRKYTKKKHLQEWKKETFKNLKLKNDNKKQKKNKKKHDKL----- KKFAPYRPKELRMKDKRKYAKKKHLQEWRKETFKGLHIKHKSKTKSKDKSKTNSK----- KKFAPYRAKELRMKDKRKYTKKKHLEEWKKETFRNI--PVESKKKHSKKKDKKRK----- KKFAPYRPKELALKDKRKLTKKKQLQQWRREVFKSKEGQVS-KKSSKHSTRR-------- KKFAPYRPKELRMKDKRKYTKKKQLQEWRKEVFKDKNGEEETRKKSHKDKSHKKH----- KKFAPYRPKELRMRDKRKYTKKKQLQQWRKEVLRGKKG----REDKPKSKKRK------- KKFAPYRPKELRMKDKRKVTKSKRLREWRKSVFENENGKSEHRHKHHHDKKKKVH----- KKLASWRGAEKKAKDQRKYGKKKRLKDWREQVFKKRDADDEIMAALQKQQKGKRR----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MYQLTF ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ VDMTMAKLEKQFRGKYRDFSMSQART---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---MTTKLKGLKELGNTSDPLRTVSY---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MGPTRSRAPKRTRFFS---------------------------------- ------------------------------------------------------------ -MWCVGVIRVDFSKHFTLVARMSIQE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----MSVQLDPSALQKMAEVAAAAEQQ-------------SNEPMTV------------- -------------MTEVEEPEQPTTI---------------------------------- ------------------------MET-------------QEKPLSV------------- ----------MDALMEKMAAVQGEEED-------------PNKELSI------------- ------------------------MEN-------------QEKPLSV------------- ------------------------MEG-------------QEKPLSV------------- ----FLLSIVLKLTVSTTANNRAAMET-------------QEKALSV------------- ------------------------MEN-------------QEKPLSV------------- ------------------------------------------------------------ -------------QVRTKMSDYEDDNT-------------DVQSLTV------------- ------------------------------------------------------------ ------------------MSEQPTEPL------------------SI------------- -----------------MQSTEPEREL------------------SI------------- ------------MSLEAEVPELGQDDS--------------QRELTI------------- ---------------------MSEQPT---------------EPLSI------------- -------------MAEEIAPGSETKEL------------------SI------------- ---------------MAEQESTEPLSI--------------------------------- -------------NFVRIRYTYPGTMA-------------EDQSVNI------------- ----------------MDENVQRELTI--------------------------------- -------------AAEAVAAATEFENQ-------------PNEELSI------------- --------------MEAQREQEEPLTV--------------------------------- --------------MASPEKETPDIGA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------DE-------------------EYELW-------K-----SNVPMLYDFVS ----------NE-------------------EYDLW-------V-----SNVPMMYDFVS ----------DE-------------------EYDLW-------K-----SNVPLMYDFVS ----------DE-------------------EYELW-------R-----SNVPLMYDFVS ----------DE-------------------EYDLW-------K-----SNVPLMYDFVS ----------DE-------------------EYDLW-------K-----SNVPLMYDFVS ----------DE-------------------EYDLW-------K-----SNVPLMYDFVS ----------DE-------------------EYDLW-------K-----SNVPLMYDFVS ------------------------------------------------------------ ----------EE-------------------EYELW-------N-----SNVPVMYEFVS ------------------------------------------------------------ ----------KE-------------------EYQLW-------R-----KNCRYMYEFVS ----------DD-------------------EYDLW-------K-----SNVPLMYDFVS ----------KE-------------------EYQLW-------R-----KNCRYMYEFVS ----------KE-------------------EYQLW-------R-----ENCRYMYEFVS ----------KE-------------------EYQLW-------R-----KNCRYMYEFVS ----------KE-------------------EYQLW-------R-----KNCRYMYEFVS ----------KD-------------------EYELW-------R-----KNCRYMYEFVS ----------KE-------------------EYQLW-------R-----KNCRYMYEFVS ----------NE-------------------EYQLW-------R-----KNCRYMYEFVS ----------DQ-------------------EYELW-------K-----TNVPLMYDFVS -------------------------------EYETW-------K-----RNCPYMYSFVS ----------ETRLTWPTLTVE---------------------W---------------L ----------ETRLTWPSLTVQ---------------------W---------------L ----------ETRLTWPSLTVQ---------------------W---------------L ----------ETRLTWPSLSLE---------------------W---------------L ----------ETRLTWPSLTVQ---------------------W---------------L ----------ETRLTWPSLTVQ---------------------W---------------L ----------ETRLTWPSLSVQ---------------------W---------------L ----------ETRLTWPSLTVQ---------------------W---------------L ------------------------------------------------------------ ----------ETKLTWPSLTIQ---------------------W---------------L ------------------------------------------------------------ ----------ETALMWPSLTIQ---------------------W---------------L ----------ETRLLWPSLTIQ---------------------W---------------L ----------ETALTWPSLTIQ---------------------W---------------L ----------ETALTWPSLTIQ---------------------W---------------L ----------ETALTWPSLTIQ---------------------W---------------L ----------ETALTWPSLTIQ---------------------W---------------L ----------ETALTWPSLTVE---------------------W---------------L ----------ETALTWPSLTIQ---------------------W---------------L ----------ETALTWPSLTIQ---------------------W---------------L ----------ETRLTWPSLTAQ---------------------W---------------L ----------ETTMTWPSLTFD---------------------W---------------- PQ---KN------------------------LVAARTRQQLI------------------ PT---E-------------------MQPREVDGQQLLRQELL------------------ PTPVQE-------------------------PEGGFIKQELI------------------ PQ---EK------------------------SAQAPNRQELI------------------ PT---PVQE----------------------LDGGFIKQELI------------------ PT---PVQQ----------------------PKGGFIKQELI------------------ PTPIQE-------------------------AEGGFIRQELI------------------ PT---PVQE----------------------SDGGFIKQELI------------------ ------------------------------------------------------------ P------------------------------SDGQSPEQSLI------------------ ------------------------------------------------------------ PN---YT------------------------TTNGLIDAKLL------------------ P------------------------------RAEDSTEQELL------------------ PE-----------------------NKTN--EAEGLIDAKLL------------------ PK---YT------------------------QSKGLIDAKLL------------------ PN---HT------------------------TQDGVINTSLL------------------ PN---HT------------------------VCNGLIDASLL------------------ PD---H-------------------------KIGDVIDAQLL------------------ PQ---HT------------------------EEDGVIQSKLL------------------ PE---HT------------------------IEGDAYESSLL------------------ P------------------------------GSEEDTRQYMI------------------ -------------------------CGYREDEAAGMGVHQAL------------------ ------------LGTHT---SG---------EEQN------------------------- ------------IGTLT---TD---------NEPN------------------------- ------------IGTHT---SG---------EEEN------------------------- ------------IGTHT---SG---------EEDN------------------------- ------------IGTHT---SG---------EEEN------------------------- ------------IGTHT---SG---------EEEN------------------------- ------------IGTHT---SG---------EEEN------------------------- ------------IGTHT---SG---------EEGN------------------------- --------------------SG-------------------------------------- ------------FGTHT---AG---------EEVN------------------------- ------------------------------------------------------------ ------------LGTHT---SN---------QSAN------------------------- ------------VGTHT---SD---------SEQN------------------------- ------------LGTHT---SG---------EDTN------------------------- ------------LGTHT---SN---------QSEN------------------------- ------------LGTHT---SG---------NDTN------------------------- ------------LGTHT---SG---------QDTN------------------------- ------------LGTHT---SG---------EDTN------------------------- ------------LGTHT---SG---------EDTN------------------------- ------------LGTHT---SG---------EDTN------------------------- ------------LGTHT---SG---------EEVD------------------------- ------------AGTFS---QD---------KEEK------------------------- -------------------Y-LKIGAVDLP----VEVTENSKKDREIDEEDED-MVLS-- -------------------Y-LKIAAIDLP----------ENVTSSKPSVSDDAKENE-- -------------------Y-LKFAEINLP------KEILNNEDPQEEAGEDD-EVSA-- -------------------Y-LKIAAIDLP----------NDIIPSTEKLEDQ-QKGE-- -------------------Y-LKFAEINLP------KEILSNEDPQEEAGEEY-QSSL-- -------------------Y-LKFAEINLP------KEVLNNENPQEQAEMGD-EASL-- -------------------Y-LKFAEINIP------KEILNNQDPQEEAEEDD-KATL-- -------------------Y-LKFAEINLP------KEILNNEDSQEEAEEND-QVSL-- ------------------------------------------------------------ -------------------Y-LKVATINLP---------AGIAGLDQGDEEDEANDHS-- ------------------------------------------------------------ -------------------Q-LKVASTQLS-------------------ADPNVKANS-- -------------------Y-LKIAEINLP----QEILSNEGPVLQNDNNGSDEQVPS-- -------------------Y-LKLASTQIP----------LSNSSNTEEKSNK-KVTS-- -------------------Q-LKVASTQLL--------------ADPNVKANS------- -------------------Y-LKVAETQIS--------------ADGTATANS------- -------------------Y-LKVASTELS-------------------ADGKVKANS-- -------------------Y-LKLASTQLP-----------RSGVQRNEGTPAPKVSS-- -------------------Y-LKVASTELP----------SSQPTESAKKATS------- -------------------Y-LKIANTQIP-----------------VSSSGD-KPMS-- -------------------Y-LKVAALDLP----------DEVVTGEANDDNR-RTKS-- -------------------EKIVLMESTIP---------LDLGDLGKLGPNGR-PADL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------NVKIVKKFP-HDG------------EI ----------------------LSHRQS-----KIKIVRKFK-HEQ------------EV -----------------------PAPRS-----NIKITAKYK-HEE------------EI -----------------------TTTKS-----NIKIIKKFK-HEE------------EI -----------------------PAPRS-----NIRITAKYE-HEE------------EI -----------------------PPPRS-----NIRITAKYE-HEE------------EI -----------------------NAPKS-----NIRITAKYV-HEE------------EI -----------------------PPPRS-----NIRITAKYE-HEE------------EI ------------------------------------------------------------ ---------------------------------SFAIANKFP-HIE------------EV ------------------------------------------------------------ ---------------------------------KIKTVQKLE-NNA------------EI ---------------------------------KIKIIKKFK-HEN------------EV ---------------------------------RIKITKKFE-NNF------------EI ---------------------------------KIKIVEKLE-NNA------------EI ---------------------------------RIKITKKFE-NTQ------------EI ---------------------------------KIKIIEKLE-NEA------------EI ---------------------------------KIKIMKKFE-NTS------------EI ---------------------------------RIKISKKLT-NDY------------EI ---------------------------------RLKITKKFA-NNH------------EI ---------------------------------NIKIVKKFE-HDG------------EI ---------------------------------RFKTVKEWS-HDG------------EP TRARYMP-----------QDDNIIAT-----INGEGKIFIY------------------- TRARYMP-----------QSPNIIAT-----LNGAGIVYIF------------------- TRARYMP-----------QNPGTVAT-----INGQGTVFIY------------------- TRARYMP-----------QNSNLVAT-----INGSGKVFLY------------------- TRARYMP-----------QDPNIVAT-----INGQGTVFLY------------------- TRARYMP-----------QDPNMVAT-----INGQGTVFLY------------------- TRARYMP-----------QNPDFVAT-----LNGQGTVFLY------------------- TRARYMP-----------QDPNVVAT-----INGQGTVFLY------------------- ----------------------LLST------------FQF------------------- IRARYMP-----------ANSNIIAT-----INGKGTISIF------------------- ------------------------------------------------------------ CRARYMP-----------QDANIVAT-----INGLGEVDLY------------------- TRARYAP-----------FDSNLIAT-----ISGTGTVFLY------------------- NRARYMP-----------QDPSIVST-----INGAGEIDLY------------------- CRARYMP-----------QDANIVAT-----INGLGEVDLY------------------- CRARYMP-----------QDTNIVGT-----INGSGQVDLY------------------- CRARYMP-----------QDPNIVAT-----INGLGQVDLY------------------- NRARYMP-----------QDANIVAT-----INGSGELDFA------------------- NRARYMP-----------QDPDTVAT-----INGEGNIDIY------------------- NRARYMP-----------QDPNIVAT-----INGGGEIDFY------------------- NRARYMP-----------KDSNIIAT-----INGEGNVSIY------------------- NKIK--------------SCGDLMAS-----INGEGTIFVR------------------- -----DRS-------------------------KNGVEALLSTLEY-------------- -----DRNI------------------------KEKDHGAIASFSY-------------- ----------------------------------SRSEGLQSTLKF-------------- -----DRS-------------------------KDKHSGLVSTFEY-------------- ----------------------------------SRSEGLQSTLKF-------------- ----------------------------------SRSDGLQSTLKF-------------- ----------------------------------SRSGGLQSTLKF-------------- ----------------------------------SRSEGLQSTLKF-------------- ------------------------------------------------------------ -----DRT-------------------------LEESKAQVSTLAF-------------- ------------------------------------------------------------ ---------------------------------NLDTETRYSHFAP-------------- -----DRT-------------------------KDDENALRGKYAY-------------- -----NL--------------------------GGDQKTAIAHFTP-------------- ---------------------------------NLDTETRYSHFAP-------------- -----KL--------------------------DSEDKLSYHHFSP-------------- ---------------------------------NVKTEEKYSHFAP-------------- ---------------------------------DLNAGKSIAHVSP-------------- -----GL--------------------------KSEEKNSLLHITP-------------- -----DR--------------------------TDDSKAAKQHYTP-------------- -----DRS-------------------------KSRSDGLRTTLKY-------------- -----SV--------------------------TGSVDETPVTLKE-------------- --H-TENG-------YGLAFNANEKY-----------SLLSGSDDSNIALW--------- --H-KENG-------YGLAFNPT--V---SG------QLLSASDDGTVALW--------- --H-EENG-------YALSFSPL--V---EG------LLLSGSDDHTVALW--------- --H-KENG-------YGLSFNCN--D---AG------KLLSGSDDGTIALW--------- --H-KDNG-------YALSFSTL--V---KG------RLLSGSDDHTVALW--------- --H-KDNG-------YALSFSPL--I---KG------HLLSGSDDHSVALW--------- --H-KDNG-------YALSFNAL--V---EG------QLLSGSDDHTVALW--------- --H-KDNG-------YALSFNTL--V---KG------QLLSGSDDHTVALW--------- --H-NENG-------YGLSFNPN--E---KG------KLLXGSDDSNIVLW--------- --H-KENG-------YGLAFNPH--I---SG------ELLSGSDDTTVALW--------- ------------------------------------------------------------ --H-TKNG-------YGLSWNPK--Q---KG------LLVTGADDNFVCVT--------- --H-KENG-------YGLNFSVA--S---PG------ELISCSDDGSIAIW--------- --H-EDNG-------YGLSWSPH--K---KG------YLLTASDDKTVVLT--------- --H-TKNG-------YGISWNPK--Q---KG------LLVTGADDHLVCVS--------- --H-SENG-------YGLSWNPL--E---KG------LLLTAADDGLACVT--------- --H-TENG-------YGISWNPK--Q---QG------LLLTGADDHWVCVS--------- --H-TENG-------YGLSWNAS--R---KG------YLLSSSDDKSVVLT--------- --H-DRNG-------YGLSWNSH--R---KG------YLLSSSDDKSIVLT--------- --H-DENG-------YGLSWNPY--L---KG------YLLTSSDDKSAIVS--------- --H-KENG-------YGLSFNPNVSN-----------ELISGSDDFTIALW--------- --H-TTNA-------FGLAWSVG------RGGAGDPEALVSGGEDGKVILW--------- --------DI----SNFEK---------------------------NIKPTITF-EDAHT --------DV----TSTA----------------------------NKSPSQTF--DVHT --------DV----NGNSD---------------------------STRPIRTW-SDLHS --------NV----NNS-----------------------------NSSPIYVW-SSVHS --------EV-----GSGGD--------------------------PTKPVRTW-NDLHS --------DV-----SGGSD--------------------------STTPIRTW-DDLHS --------EV----GSNST---------------------------SISPVRTW-NDLHS --------DV-----GSSGD--------------------------SIKPTRTW-NDLHS --------DV----TGK-----------------------------SQEPILTF-TDRHS --------DI-----------------------------------EAAKKPKSI-LTSHD ------------------------------------------------------------ --------DT------------------------------------TTNKTTFK-SDIQK --------DI-----KSG----------------------------KTVPTSVN--SLHS --------DT----SRLDAT--------------------------DLSQVCKF--TTHK --------DT------------------------------------TTTKTIFK-SDIQK --------DV----------------------------------LGSYKTTVFK-SSTNT --------DT------------------------------------NKDNATLFKSDVQK --------DF----NTL-----------------------------DKNDGRVFRSEVHT --------DI----NREA----------------------------LTSNQIFK-NNSHS --------DY----SKI-----------------------------ATNEAQVFKTTSHD --------DI----DSG-----------------------------SKSPKSVW-DNIHS ----------------------------------------------NLESKKST-WNITT DIINDVKWHSSE-AHIFGSVSEDSTMKLFDKRSSQ------------IIHNI----NTK- DIVNDCKWHEFQ-SSLFGTVSEDNTLIIHDTNSDR------------AIQKL----SVS- DIVNDSKWHNFN-KDLFGTVSEDSLLKINDLRVEN------------TTTGT---AKCP- DIVNDCKWSNFD-LNVFGSVSEDSTLQLHDQREKD-TFT--------SQFKV------D- DIINDNKWHNFN-KDLFGTVSEDSLLKINDVRANN------------TTIDT---VKCP- DIVNDSKWHNFN-KDLFGTVSEDSLLKINDIRAEN------------TTIDT---AKCP- DIVNDIKWHNFN-EKLFGTVSEDSLLKINDVRAHN------------ITIDA---VKCP- DIINDIKWHNFN-KDLFGTVSEDSLLKINDVRADN------------TTIDT---VKCP- DIVNDCKWHNFD-QNIFGSVSEDSTLQLHDQRIRD-A----------AVEKV---QAKK- DIVNDVKWHEFE-SNVFGTVSEDKTLQVHDKRV---RLE--------PVKKL----PTA- ------------------------------------------------------------ DIVNDVKWHQFN-GNLFASVSEDSHVYLFDARDNK------------VVSQY--YAESS- DIVNECKWHESD-PNIYGSVSEDSFLMIHDKRSEK------------PLQKL----LQK- DIVNDAKWHQFD-ESLFGSVSDDKYFYLFDIRTPG---E--------PVSKF--YHPES- DIVNDVKWHQFN-GNLFASVSEDSHVYLFDIRDNK------------VVSEY--YAESS- DIVNDAKWHFFD-KSIFATVSEDEYAYIFDTRTTE------------PVAKY--HAEGS- DIVNDVKWHQFD-GNLFASVSEDKHLYLFDIREKK------------EIATY--HAESS- DIVNDVKWHAFD-ENVFGSVSDDEKMLLFDTRSPE------------KAVSC-YSSVGS- DIVNDVKWHTLD-ENMFASVSDDKHAYIFDLRTPN---R--------PVSLF--YNEVS- DIVNDAKWHGHE-AHVFGSVSDDNRFRLFDIRASATT----------PVSVY--HDDTA- DIVNDCSWHHFD-ENLFGSVSEDSTLKLHDKRSTS------------KVINT---IQAK- SSVNDVECHKTF-PYIIGAALEEGFIALYDTRAPE-TAG--------GTLTRPPSGDKP- --------------------KPYNTLAFSPFS-SNLFAAAGTDNLVYLYDIRDVSN---- --------------------SAFNTLAFSKRS-ENLLAAAGTDSNVYLYDLRRLQK---- --------------------EPFNTLAFSHHS-SNLLAAAGTDSHVYLYDLRNMKE---- --------------------APFNTLAFSKHS-QYLFAAAGTDSHVYLFDRRDISR---- --------------------QPFNTLAFSHHS-SNLLAAAGMDSYVYLYDLRNMKE---- --------------------QPFNTLAFSHHS-SNILAAAGMDSHVYLYDLRNMKE---- --------------------QPFNTLAFSHHS-SNLLAAAGMDSHVYLYDLRNMRE---- --------------------QPFNTLAFSHHS-SNLLAAAGMDSYVYLYDLRNMSE---- ---------------------PYNTLAFSAHS-TNLFAAAGTDSMVYLYDRRRASK---- --------------------SPFNTLSFSKHS-RNLLAAAGVDSQIYLYDMRDMSS---- ------------------------------------------------------------ --------------------NGINSLAFSPFA-ENLVAIGNTSSNINLLDLRKLGE---- --------------------EPFNTIAFSKHS-SNLFAAAGTDAMVYLFDSRKPTE---- --------------------EGINSLSFSPFS-QYLVATGNANSNISLLDTRKLST---- --------------------NGINSLAFSSFA-ENLMAIGNTNSNINLLDLRKLDL---- --------------------KGINSLAFSPFS-RNLLAIGSTNSNISLLDTRKLDN---- --------------------GGINSLAFSPFA-HNLIAIGNTNSNINLLDMRKLGP---- --------------------KGINSLAFSPFS-KNLLAIGDTNSNINLLDLRKLSS---- --------------------DGINSVAFSPFS-KYLLAVGNTNSNINVLDLRKFSN---- --------------------KGINTLSFSPFS-HHLVALGNANSNIGLIDTRKLSS---- --------------------AAFNTLAFSKHS-ANLFAAAGLDTNIYLYDRRQTTK---- --------------------TPYNCLAFSPHS-EYLFAAGSSESTVNLYDIRNTGY---- ----------PLYAM---------TGHED-AV-----------TAIEFD-PNNDGILYSS ----------PLHSM---------AGHED-SV-----------TSLEFS-PHQDGLLTSS ----------PLHHM---------SGHED-AV-----------TNLEFS-PHVDGVVVSS ----------PLHSM---------AGHDG-AV-----------TNMEFS-PDQDGILMTS ----------PLHHM---------SGHED-AV-----------NNLEFS-THVDGVVVSS ----------PLHHM---------SGHED-AV-----------TNLEFS-PHVDGVVVSS ----------PLHHM---------SGHED-AV-----------TNIEFS-THVDGVVVSS ----------PLHHM---------SGHED-AV-----------TNLEFS-THVDGVVVSS ----------PLHMM---------PGHED-AV-----------TSSEFH-PQEGRCPNIC ----------PLHVM---------SGHQD-SV-----------TTVEFS-PHTDGIICSS ------------------------------------------------------------ -------NSGLLHTM---------MGHSE-GI-----------TCMEFS-PHHDGILATG ----------ALHSM---------SGHQE-AV-----------TSLEFA-HHKDGILCSG ---KSAVSDGLLHTM---------MGHSD-SI-----------TSLEFS-PHKDGMLASG -------SSGLLHTM---------MGHSE-GI-----------TCMEFS-PHHDGILATG ----KNGTAGLLHTM---------MGHTD-GI-----------TSMDFS-PHKDGILASG -------TSGLLHTM---------MGHSE-GI-----------TCMEFS-PHNDGILASG ----ISKGGEALHTM---------MGHGD-AI-----------TCLEFS-PHKDGIIASG ---NVKSKDGLLHTM---------MGHSD-SI-----------TSLEFS-PHRDGIIASG ----STKKEGLLHTM---------MGHSD-AL-----------TSMEFS-PHKDGILATG ----------PLHVM---------AGHED-AI-----------TCLQFH-PKEDGILVSG ----------RLHSL---------SGHNG-AV-----------TGIEFD-PFHGQYLATG G-SDRRTIVWDLQ----------------------------------------------- G-SDRRIIMWDLF----------------------------------------------- G-SDNRLIMWDLK----------------------------------------------- G-EDRRAIIWDIC----------------------------------------------- G-SDNRLMMWDLK----------------------------------------------- G-SDNRLIMWDLK----------------------------------------------- G-SDNRLIMWDLK----------------------------------------------- G-SDNRLIMWDLK----------------------------------------------- G----------------------------------------------------------- G-SDRRAIIWDLT----------------------------------------------- ------------------------------------------------------------ S-QDRRIIIWDLF----------------------------------------------- G-SDRRVLLWDLF----------------------------------------------- S-QDRRLILWDLF----------------------------------------------- S-QDRRIIIWDLF----------------------------------------------- S-QDRRLILWDLT----------------------------------------------- S-QDRRVIIWDLF----------------------------------------------- S-QDRRVIIWDLS----------------------------------------------- A-QDRRLIVWDLF----------------------------------------------- S-QDRRLILWDLF----------------------------------------------- G-ADRRVILWDLA----------------------------------------------- G-QDRRVIIWNMN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EIG-AEQ -----------------------------------------------------NIG-AEQ -----------------------------------------------------QIG-AEQ -----------------------------------------------------DIG-VEQ -----------------------------------------------------QIG-AEQ -----------------------------------------------------QIG-AEQ -----------------------------------------------------QIG-AEQ -----------------------------------------------------QIG-AEQ ------------------------------------------------------------ -----------------------------------------------------QIG-AEQ ------------------------------------------------------------ -----------------------------------------------------KVG-EEQ -----------------------------------------------------QIG-TEQ -----------------------------------------------------KVG-EEQ -----------------------------------------------------KVG-EEQ -----------------------------------------------------KIG-EEQ -----------------------------------------------------KVG-EEQ -----------------------------------------------------KIG-EEQ -----------------------------------------------------KIG-EEQ -----------------------------------------------------KIG-EEQ -----------------------------------------------------EIG-AEQ -----------------------------------------------------TIG-CEQ T-------------------------------------------------QD--EIEDGP Q-------------------------------------------------PD--DAYDGV T-------------------------------------------------PD--DAEDGV I-------------------------------------------------PD--DAEDGA T-------------------------------------------------PD--DAEDGV T-------------------------------------------------PD--DAEDGV T-------------------------------------------------PD--DAEDGV T-------------------------------------------------PD--DAEDGV ------------------------------------------------------------ S-------------------------------------------------QD--DADDGA ------------------------------------------------------------ Q-------------------------------------------------QE--DAEDGC Q-------------------------------------------------EE--DADDGG A-------------------------------------------------QE--DAEDGC Q-------------------------------------------------QE--DAEDGC Q-------------------------------------------------QE--DAEDGC Q-------------------------------------------------QE--DAEDGC V-------------------------------------------------QE--DAEDGC Q-------------------------------------------------QE--DAEDGC A-------------------------------------------------QE--DAEDGC Q-------------------------------------------------PD--EADDGS S-------------------------------------------------QD--DAEDAS PEV-------LMIHAG-------------------------------------------- PEL-------FMMHGG-------------------------------------------- PEL-------IMVHAG-------------------------------------------- PEV-------LMIHAG-------------------------------------------- PEL-------IMVHAG-------------------------------------------- PEL-------IMVHAG-------------------------------------------- PEL-------IMVHAG-------------------------------------------- PEL-------IMVHAG-------------------------------------------- ------------------------------------------------------------ PEL-------MMMHAG-------------------------------------------- ------------------------------------------------------------ PEL-------FMMHAG-------------------------------------------- PEL-------LMMHAG-------------------------------------------- PEL-------FMMHAG-------------------------------------------- PEL-------FMMHAG-------------------------------------------- PEL-------FMMHAG-------------------------------------------- PEL-------FMMHAG-------------------------------------------- PEI-------FMMHAG-------------------------------------------- PEL-------FMMHAG-------------------------------------------- PEL-------FMMHAG-------------------------------------------- PEI-------LMIHAG-------------------------------------------- PEL-------FFMHGG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------HKTSIND-------IAV--------------------------- ----------------HRSPVNE-------FSH--------------------------- ----------------HKSAVND-------FDL--------------------------- ----------------HRSAIND-------FSM--------------------------- ----------------HRSSVND-------FDL--------------------------- ----------------HRSAVND-------FDL--------------------------- ----------------HRSSVND-------FDL--------------------------- ----------------HRSSVND-------FDL--------------------------- ----------------QRQKNNS-------LGF--------------------------- ----------------HRSPVNE-------FSF--------------------------- ------------------------------------------------------------ ----------------HTAGVSD-------LSW--------------------------- ----------------HKSAIND-------FSF--------------------------- ----------------HTGAVTD-------LSW--------------------------- ----------------HTAGVSD-------LSW--------------------------- ----------------HTAGVTD-------LSW--------------------------- ----------------HTAGVSD-------LSW--------------------------- ----------------HTGAVTD-------LSW--------------------------- ----------------HTGSVTD-------LSW--------------------------- ----------------HTGGVMD-------LSW--------------------------- ----------------HRSAIND-------FTL--------------------------- ----------------HTAPVSA-------FAY--------------------------- -----NP--NIN----------------------------------------------W- -----NS--NVP----------------------------------------------W- -----NA--QIP----------------------------------------------W- -----NP--NIP----------------------------------------------W- -----NP--QIP----------------------------------------------W- -----NA--QVP----------------------------------------------W- -----NA--QIP----------------------------------------------W- -----NP--QIP----------------------------------------------W- ---------GRN----------------------------------------------W- -----NP--QIP----------------------------------------------W- ------------------------------------------------------------ -----CP--FKD----------------------------------------------W- -----SP--NVP----------------------------------------------W- -----CP--YKD----------------------------------------------W- -----CP--FKE----------------------------------------------W- -----CP--FRE----------------------------------------------W- -----CP--YKD----------------------------------------------W- -----CP--FVD----------------------------------------------W- -----CP--YKD----------------------------------------------W- -----CP--YKD----------------------------------------------W- -----HP--TIP----------------------------------------------W- -----NP--EME----------------------------------------------W- ------------------------------------------------LVAS-------- ------------------------------------------------LMCS-------- ------------------------------------------------LVAS-------- ------------------------------------------------LMAS-------- ------------------------------------------------LVAS-------- ------------------------------------------------LIAS-------- ------------------------------------------------LVAS-------- ------------------------------------------------LVAS-------- --------------------------------------------------CR-------- ------------------------------------------------LLAS-------- ------------------------------------------------------------ ------------------------------------------------MIGS-------- ------------------------------------------------LMAS-------- ------------------------------------------------TIGS-------- ------------------------------------------------MIGS-------- ------------------------------------------------TIGS-------- ------------------------------------------------TIGS-------- ------------------------------------------------TLAS-------- ------------------------------------------------TIGS-------- ------------------------------------------------TLGS-------- ------------------------------------------------LSAS-------- ------------------------------------------------CLGS-------- ------------------AEE----D-------NIVQ----------------------- ------------------VEE----E-------NVLQ----------------------- ------------------TEE----E-------NILQ----------------------- ------------------SEE----E-------NIIQ----------------------- ------------------AEE----E-------NILQ----------------------- ------------------TEE----E-------NILQ----------------------- ------------------SEE----E-------NILQ----------------------- ------------------AEE----E-------NILQ----------------------- ------------------TST------------RRCG----------------------- ------------------TEE----D-------NVIQ----------------------- ------------------------------------------------------------ ------------------VAD----D-------NIVH----------------------- ------------------VEE----E-------NIVQ----------------------- ------------------VAD----D-------NIVH----------------------- ------------------VAD----D-------NIVH----------------------- ------------------VAD----D-------NIVH----------------------- ------------------VAD----D-------NIVH----------------------- ------------------VAD----D-------NIVH----------------------- ------------------VAD----D-------NIVH----------------------- ------------------VAD----D-------NIVH----------------------- ------------------VEE----D-------NVVQ----------------------- ------------------VSE----D-------NIAQ----------------------- -----------IW----------------------------------------------- -----------IW----------------------------------------------- -----------VW----------------------------------------------- -----------VW----------------------------------------------- -----------VW----------------------------------------------- -----------VW----------------------------------------------- -----------VW----------------------------------------------- -----------VW----------------------------------------------- ------------------------------------------------------------ -----------AW----------------------------------------------- ------------------------------------------------------------ -----------LW----------------------------------------------- -----------IW----------------------------------------------- -----------LW----------------------------------------------- -----------LW----------------------------------------------- -----------LW----------------------------------------------- -----------LW----------------------------------------------- -----------LW----------------------------------------------- -----------LW----------------------------------------------- -----------LW----------------------------------------------- -----------VW----------------------------------------------- -----------IW----------------------------------------------- --------------------------------------------KC---SSNIPRIGG-- --------------------------------------------KP---ANKIVRPPQ-- --------------------------------------------KC---SHSLPVVGG-- --------------------------------------------KC---SHKLPRVGG-- --------------------------------------------KC---SHSLPIVGG-- --------------------------------------------KC---SHSLPIVGG-- --------------------------------------------KC---SHNLPIVGG-- --------------------------------------------KC---SHSLPIVGG-- ------------------------------------------------------------ --------------------------------------------KV---SMKLVNASP-- ------------------------------------------------------------ --------------------------------------------EI---SKKLITNEE-- --------------------------------------------KP---SRKLTNPYF-- --------------------------------------------EI---GKTLLNAEK-- --------------------------------------------EI---SKKLITNEE-- --------------------------------------------EV---SKSLINDPL-- --------------------------------------------EI---SGQLISNEE-- --------------------------------------------EI---SKSLVEDAP-- --------------------------------------------EV---GKSLLEDGV-- --------------------------------------------QV---GSSLVNADT-- --------------------------------------------KC---SKNLSRVGG-- --------------------------------------------GV---SDKIYSPTE-- -----EPEVDLSILD--------------------------------------------- ----PPADFDITTLE--------------------------------------------- -----PPKVSMDMIS--------------------------------------------- -----TPTVSVSQLE--------------------------------------------- -----PPKVNKDIIS--------------------------------------------- -----LPKINKDIVG--------------------------------------------- -----PPKVNKDIIS--------------------------------------------- -----LPKVNKDIIS--------------------------------------------- ------------------------------------------------------------ -----PAISDPSLLV--------------------------------------------- ------------------------------------------------------------ ------AEVDVSILE--------------------------------------------- -----PQGYDIRSLE--------------------------------------------- -----GIELKDTDLE--------------------------------------------- ------VEVDESVLE--------------------------------------------- -----NEEVDPSILE--------------------------------------------- ------TDVDVTVLE--------------------------------------------- ------AVVNDADLE--------------------------------------------- ------GEIKETDLE--------------------------------------------- -----PEHIKPSDLE--------------------------------------------- -----TPEIDTKMLQ--------------------------------------------- ------LEVIEDTLE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MKRLECHSSEADCFRI ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SLTT---------------------------------------------SNCAKQIPLGS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ --------------MNNTNWK--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MDSNWK--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MCCDSIKKGLNIICSYS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------D ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MSRTLK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ YLLQRAIFERLLSA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MTSFFVST-------------------------------------------------- ---------MSTTNSDSNG----------------------------------------- ------------------------------------------------------------ ---------MSTYDWK-------------------------------------------- ------------------------------------------------------------ ---------MNKTNWK-------------------------------------------- ------------------------------IIDMNGHTHKYIH--IYIYI------YIYV ---------MNKRKWK-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GVDYDLYAIGFQE----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M -----------------------------------------------------------M ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LWD------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MTDSNWK----------------- ------------------------------------------------------------ YTSSKIVL----------------------------------------------LTAIIV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MTHDYN----------------- ------------------------------------------------------------ ------------------------------------------------------------ DTNENIP----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SSDSQIP----------------------------------------------------- TIPKEIP----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VSVVTLN---------- -------------------------------------------VFASSFN---------- -------------------------------------------VSVTTFN---------- -------------------------------------------VSITTFN---------- -------------------------------------------VSVTTFN---------- VKNENLLNNELKNANQYQRQVGRKNSTQSDQ------------MNKSKW----------- -------------------------------------------VSVTTFN---------- -------------------------------------------VSVTTFN---------- ------------------------------------------------------------ LLPIWDASCPLQTKSCLRRLVP---------------------VILQRLNSGVE------ -------------------------------------------IFVSTFN---------- ---------MIEGSTKSESDIP---------------------LYLFTYN---------- ------------MSSEYS-------------------------IFVSTFN---------- -------------------------------------------LYLLTYNCNKQ------ ---------MIEYSTKKESDIP---------------------LYLFTYN---------- -------------MSQLKNQIP---------------------LFLFTYN---------- ------MSETKETQHSKEDQLP---------------------LYLFTYN---------- -------------------------------------------LFLLTFN---------- -------------------------------------------LFLFTYNCNKR------ ------------------------------------------------------------ -------------------------------------------IQITSFN---------- -----FNCGKLTQDTQYYQHLS---------------------AELAGID---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------KVSITTFN ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ CARDF----------PFRDQQEKLAILKELI----------------------------- CAKVF--PFDDI---DTQKSILEQ-LIPHVS----------------------------- CGKEFPVENSKA---IVKQLLFPY------------------------------------ CEKEF--PVDPSLENVRSLIIKRLLFKHRHE----------------------------- CGKEFPVENSKA---IVKQLLFPY------------------------------------ CGKEFPIENTKG---IVKQLLFPY------------------------------------ CGKEFPVENSKA---IVKQLLFPY------------------------------------ CGKEFPVENSKA---IVKQLLFPY------------------------------------ ------------------------------------------------------------ -------DTPEV---PVDRNVQHS------------------------------------ CGKAF--PFDDA---SHTEAVVRS-LIPSQT----------------------------- CNK-----------RVIDA----------------------------------------- CGKCL----------PIDQPI--------------------------------------- ---------------KLDYDLVIPKIMESLP----------------------------- CNK-----------RVIDA----------------------------------------- CNK-----------KKLIP----------------------------------------- CNK-----------QVIEN----------------------------------------- ---CA----------KLKLNAAEF------------------------------------ ---------------ELNHDLFIQKVVESFP----------------------------- ------------------------------------------------------------ CGKAF----------HKERDSIEDISYKLIG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------TFNSNN--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NVFKSKVSQSLPP---KDN- --------------------------------------EIDSILASLIPSGV-------- ------------------------------------------------------------ ----------------------------------------NVFKSKVSQSLPP---KDN- ----------------------------------------ELFQSKIQEVLP-----DE- ----------------------------------------NSFKSKVAESLP-----DT- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MFHESSNQFLASMSIPIYLFTFNAGKR----RAND -------------------------------------------------DGI-------- ------------------------------------------------------------ ---------------------AQDIYAFGFQELVRIW----EGAGKIRM-EAALIDILKD ---------------------HHDIYILGFQELMSIW----QGSFSNIC-FQYLEGLSKL -DDGISQLE------------LQDIYVLGFQELVPIW----QGSFPTVN-RDLIDKITTT ---------------------VKDIYVFGFQELAPIW----EGSFPSIM-NSYTDTLYQS -DDGISQLE------------LQDLYVLGFQEVVPIW----QGSFPAVN-RDLIDRITTT -DDSISQLE------------LQDIYVLGFQELVPIW----QGSFPTVN-RDLINGITTT -DNGISQLE------------MQDVYVLGFQELVPIW----QGSFPTVN-RDLIDGITTT -DDGISRLE------------LQDVYVLGFQELVPIW----QGSFPAVN-RDLISGITNT ------------------------------------------------------------ ---------------------EADSLLGSLE----------RQAIGDTE-QSNQNAWPSR ---------------------AHDVYALGFQELVPIW----EGSFPKLV-EARLLELSKA ---------------------PSHLYVFALQEFCTIL----DGSFKASA-NQQLIAYNEL ---------------------THDIYALGLQELVAIW----QGSFPLLL-EELLKNLAIR -DQ------------------LSTLYVFGLEELCSII----DGCFVENA-SNHLIKFNKF ---------------------PSHLYVFALQEFCTIL----DGSFKASA-NQQLIAYNEL ---------------------LLSLFVFGFQEFCSVL----DGSFVEDA-NRHLIEMNQL ---------------------PSLLYVFAFQEFCSIL----DGSFKDLS-NQQLISYNET -IDHVIGALPQA---------ACDLYVFGFQEVCSIL----DGAFPDIV-NRHMIEINRI -TD------------------LAALYVFGLEELCPIL----DGSFHDIA-HKHMIRFNEV EGRRLVSTFPQE---------PASIFVFGLEEMGTII----EGAYGPSS-RACLREYNDL ---------------------AQDMYIFGFQEFTKIW----EGSFGRIV-NSYLQVFALI ---------------------APHVLLFGYQELCSIP----DGCL-----GYAVDPLNDL ILDILDELFPQNN-----YKKLGYSYVGATAVLVVGKETIE--CHDSASTTSNCGKFGST VLNRINTEET-------TFKCVDINCLGAIGLMVFCKEELE--VTNILKTNVKCGVF-YS AIDCLNEKVKGIRGDEQ-YSCLGVSSLGAITMIVLYNNNKLRVREDVLKRNGKCGWFSTH IASVLQTLFP--ADE---FKLIGSETVGAIAMLVIGHASVT--VNEVLKNKVRCGMLDSS AVNCLNEKVSATQGDEQ-YSCLGVNSLGAITIIVLYNNNALKVKDDILKRNGKCGWFGTH AIDCLNEKVIAFRGGEQ-YSCLGVNSVGAITMIILYNNNALKVKADILKRNGKCGWFSTH AVDCLNEKVMALQGDEQ-YSCLGVNSLGAITIIVLYNNKAL----NVKGSIKRNGKCGWF AIECLNEKVTAIQGNEQ-YSCLGVNSLGAITIIVLYNNNALKVKGDILKRNGKCGWFSTH ------------------------------------------------------------ QVPVS-------------YRFVACNAIGAVGLMLFAKEDLK--VEVLRTCNVRTGALGSS VLTRLEAVSH----GRG-YQLVGSNSVGAVGLLVYAASDIA--ASNVLKAGVKLGMF-YS LQVMLFEEYG-----TDHFQTIAINHTGAVGLIII--SPYPSKFQNVRLANTSCGY-GYS VLRHINSLSE--SRT---YKLAASNSVGAIGLLVFVDANY-GVMNPLKAS-AKCGAL-YS FIEALNRKYG--TEDVK-FHTIGMNHIGAIGIIAITPYPLK--FHKLRLGRSGCGY-GYS LQIMLFEEYG-----TDHFQTIAINHTGAIGLIII--SPYPLKFQNVRLANTSCGY-GYS LQLTLQEKYN----LTSSLQTVSMRIMGSIAMIIL--SPFASKFAQVRTATGSCGY-YYL IQVMLFEKYG-----MDCFQTLAMNHIGSIGLIVL--SPFAPRFSNIRTATSSVGY-GYS LLDTLHEKYHSPSSPYN-FTTVGLHHVGAIGMIAISPFG--SRFRDCRFADASCGS-AHS FLHSLRKKYG--HNDHR-FQTIAMHHIGATGLIVITPFPLKHSIKKAQSS---CGS-GYS FLDALNGFYG--EDIAR-FHTVGMVSVGAIGLVAITPYP--SKYTQVREAKSGCGY-GYS TLNLLHDKYPDKR-----YNISGLGSLGAIGIIIIVDDI--IRVNRTKYAYCKKGILGSS IQQVLKAIRD--QPWLERYVVVGQHTFGAMGLVAIASADVL--VTDVKLCHVACGMF-WS L-KGGTAYSFRLKK----NESTVFTFISCHLNANEGEDNMTSRINDYDRIMTQCNRD--- SLKGASVIRFSILH---EGVSDTITCVTSHLAANEGLINLEKRIQDYHAIMSSLRNE--- L-KGGTLMSFNMRR-NSDANWERFSFICVHLNANEGANNRNQRINDYKRIMSEVC-D--- -LKGGIGMCCTLQK--NGGVNGTFTFICSHLTANEGEKNIIRRREDFQSIMDSCDTQ--- L-KGGTLISFQMTR-NGEENWERFSYICAHLNANEGVNNRNQRIDDYKRIMSEVC-D--- L-KGGTLVSFNMAR-NGDENWERFSFICAHLNANEGANNRNQRIDDYKRIMSEVCDP--- NNKGGTLISFKMAR-SGDENWERFTYICAHLNANEGVNNRNQRINDYKRIMSELC-D--- -LKGGTLLSFQMAR-NGEENWERFSYICVHLNANEGVNNRNQRIGDYKRIMSEVC--D-- ------------------------------------------------------------ L-KGSTAIQVQLSN---SRCSQKFTFITSHFAAKEGPDKLAQRIKDYHTTMR--TFD--- GLKGAAAVKVTFSDKDNQEAYDTFTFVSAHLAANEGSENLERRISDYASIVQQLKAD--- SMKGGVGVRLRYYPGKYGDNSVELSFAGIHLNAYEGEYYYLQRNANLLRIVRSLDFGDGY SLKGATAVKFSIQI-PGKALTDSFLFVTAHLAANE--GELQKRESDYHTIVNILQSE--- SMKGAAGIRLSYIPEGRHESTKSMTFANFHLSAYEGDHYFQKRNNEVNLLMRSMDFGDGY SMKGGVGIRLKYYPGKYGDNSVELSFAGIHLNAYEGEYYYLQRNANLLRIARSLNFGDGY SLKGGVGTRLTYYPDS----SKSLSFAVLHLNAFEGEYYYLQRNQSLRDIIRALDFGDGY SMKGGVGIRLKYSPNM---KSVELSFAGIHLNAFEGEYYYQQRNQNLLTIMRSLEFGDGF SLKGGVGLRVKYVP-----NSQTFTFACSHLNANEGEYYYQRRLKDLYAVMRALDFGDGF SLKGAAGVRLTYAPDGKYANDNSLTFANAHLSAYEGEFYYRRRNDNVTTIMRSLDFGDGY SMKGAVGLRVKYIPTQGKETSVEMSFVNAHLSAFEGDYYYQKRNQNLNFLMRSLDFGDGY L-KGAVSTTITCSK--NDREEETFSFICSHFNANEGETNMKCRIDDYNCILTEIDSQ--- SLKGAVGLRLNVDG-------NPVVCVAAHLAANE--GFLEQRNDDFATIAKEMKFLR-- -----------------FSDLRKGHIFVFGDLNFRV-NDPNF----KA----HIASEW-- -----------------FGEMELSHVIFTGDLNFRLNKFFGD----VD----------YR -----------------SAIIKSDHFFFLGDLNFRV-TSPYD--PATD----------YS -----------------FGDYKDYHVFFFGDLNYRVKGWNHL--NNTD----------YS -----------------SEVAKSDHFFFLGDLNFRVTSTYDP--TTNYSSTTTL------ ------------------EVASSDHFFFLGDLNFRVTSAYDP--ATDYSSTTTL------ -----------------SEIAKSEHFFFLGDLNFRVGSAYDP--ATDYSSATTL------ -----------------SEIAKSDHFFFLGDLNFRVTSTYDP--ATDYSSTTTL------ ------------------------------------------------------------ -----------------KHLDQDGHVFFFGDLNFRISPRQPT--DLQYSDQPVI------ -----------------FGQFPDSHTIFFGDFNFRVNKQEEA--DIRYTESQVI------ -----------------GLIKPNNHVFILGDLNYRTTKEYKKTSVVAQNLLSLADQHSEF -----------------LGSFEGNHVFFCGDFNFRSSKWAVD--TSDYSNLELL------ -----------------SLLKPRAHCFVMGDLNYRTTKKYDP--NSNQ----LLNLQDKL -----------------GLIKPNNHVFILGDLNYRTTKDYKKTSVVAQNLLSLADQHSEF -----------------GLIKPDNHIFIMGDLNYRT-SKDYH--SSSPESQELLSLQDKK -----------------GLIKPNNHIFIMGDLNYRTTQNYKKTSVVTQNLLALADQHSTI -----------------SFLKPNCHSFFMGDLNFRTSKVVSKGKPSAA----LADFLDGS -----------------GLLKDGSHTFFMGDLNYRTTKNFDPTSDANKRLISLLDQSLVT -----------------GFVKPGSHSFFMGDLNYRTTKKFSPDSEVQD----QSQATKDL -----------------LRLTRNGHIFFFGDLNFRLNKFING--NEIEFNNDLI---R-- -----------------TGIYDDATVFFLGDLNYRASENEQG------------------ -EPTLRKHEELNHLRAKHVIFRGFDEQPVTFPPTYKYK-VGDMIYNNK--------RIPS DSQLLNENDELRDVMKSERAFTQFLEPSIQFPPTFKYNIPKDDIYNFK--------RQPS SRRLLENNDELNLLRKEDPLCKGFHELEIKFPPTFKFKLFEKETYNTK--------RIPS NNELLGNYEEFYHSKQSYDTYKNFIEARINFPPTYKYL-RGSYKYNTK--------RIPS -RRLLENHEELNLLRKEDPLCKGFQELKITFPPTYKFKLFEKETYNTK--------RIPS -RRLLENNEELNLLRTENPLCKGLHELEINFPPTFKFKLFEKETYNRK--------RTPS -RRLLENYEELNLLRREGPLCKGFQELEIKFPPTYKFKLFEEEKYNTK--------RIPS -RRLLENYEELNLLRKEDPLCKGFQELEIKFPPTFKFKLFEKETYNTK--------RIPS ------------------------------------------------------------ -DHLLATYDELNRERTAGTVFEGFEEAKINFPPSYKYL-QDNLNYDYT--------RQPS -GRLLASSEELGANRKAGKIFREFDEAEITFPPTYKYS-VTESAYNPK--------RQPS DNQLFVQYDELHNALKNGEVLFGFSEGKINFKPSYKYY-LNTGIYNSK--------RCPS -QGAVETEDELNVSRKAGKVFKEFQEAPIKFAPTYKFH-VSAPSYNPK--------RIPS DEELVKNYDELTEERHNGNIFAGFSEACINFRPTYKYH-LNTAIYNRK--------RSPS NNQLFVQYDELHNALKNGEVLFGFSEGKVDFKPSYKYY-INTGIYNSK--------RCPS IESLVLKYDEFAQTMRSGEVLQNFAEPKVRFPPTYKFH-VNTAILNSK--------RSPS DHQLFSQYDELHKGLKNGEVLLGFSEGKIEFQPTYKYY-INTAIFNSK--------RSPS IMSLVRKYDELTEGKNKGELFTGFSEPDITFQPTYKYY-LDTAIYNTK--------RCPS NEELVKDCDELTWAIENGQIFTGFTEACIDFQPTYKYH-VNTAVYNSK--------RSPS PRKFLAQYDELTLGMKAGDMLNGFSEGEINFNPTYKFV-YPTAIYSTK--------RSPS -QKLLENHDELNLLRKDSKIFQEFEEVPIKFPPTYKFLIFQENYYNLK--------RTSS -LADYKVVDELFYAMRSLDAFWDFQEAEIGFKPTYKFH-TGTSEYNTK--------RIPS WCDRILYKKYPS--GLP-------MGKARYESLEHMQFTDHQAVGLAIQVPDLTKDNKHE WCDRILYSNI----SKD-------AKPTLYKAIPIFHFTDHQPVILSIELPHI----EPP WCDRILYK------TYA-------APRLTYHSVPALLFSDHQPVNLTVKLPRSTGETGPL WCDRILYR------APNFKEDIDKLTE-VYTSVDELQFTDHQPVMLVINLP--QLSETRL WCDRILYK------SYA-------VPTFTYHSVPALLFSDHQPVNLTVRLPRSTGTPVPL WCDRILYK------KYA-------TPTLTYHSVSALLFSDHQPVNLTMALPRPIGERRPL WCDRILYK------EYSTPISE--QES-TYRSVSALLFSDHQPVNLTVALPRSTGGVESL WCDRILYK------RYA-------MPTLIYHSVPALLFSDHQPVNLTVRLPRSTGIAGPL ------------------------------------------------------------ WCDRILYK------NDPKR-----VRVHRYASIDILNYTDHEPVTLSVSCHTQFVPMAMQ WCDRILYK--------------------KYNG--SVKVEGYTSVARTAPCGSQ------- WCDRILFLSTYETTGNDDLG----LQLLKYDCIDELLLSDHRPVFAHIDIPFAPPKSSPM WCDRVLFR--KY--DKN-------PEIIEYNSCEALQFTDHLPVFLQLRVPHFSSQSQVR WCDRILYQSTYKNNKKESSPV---LPQVEYGSIQSILSSDHQPVYLSITVPTS----PPE WCDRILFLSTYETIGNDDLG----LQLLKYDCIDELLVSDHRPVFAHIEIPFAPPKLSPM WCDRIVYLSTYEEIGDDSLGVNL-LRMKQYTSIPSLMLSDHRPVYLNIVVPFNPPQLIIS WCDRILFLSTYED-GEH-------LNLLKYDSVNSLLLSDHRPVYLRISVPFKPPKSSPM WCDRILFQNTYKV-GHR-------PHVYKYSSIDTYKRSDHRPVYLHLSVPYIAPESIIG WCDRILYQMTYEDSDEDQVVMLRLLPIIEYNSIKSLLQSDHQPVFLHITVPFT----APK WCDRILYQSTYRAPGSKEKVL---LAPVNYNSL-DVLLSDHQPVYLNITVPFHPPEPIVN WCDRILFL------KYENPQIT--IQT-DYKSIKELVFTDHQPVTLMVNLPIGTTTNKLK WCDRVLYR------GAV-------VPR-KYDSIPAVMSSDHKPVYLWASVKLTQSTAVEQ LELIRLL-----------EPLNETLGYFADTLLA-------------------------- N-ITRGV-SSSPSPTSSTSSLSLSFGRMVDYIIG-------------------------- LLPIERY-SLGWS--------SHLVGKIGDVVLG-------------------------- ISLEQGP--------IVSNLQPNTLGDAVDIIIG-------------------------- SLHIEKY-PLSWS--------SGLIGQIGDAVIG-------------------------- SLHIEKY-HLSWS--------SGLVGQVGDAVIG-------------------------- SLNVEEY-HLAWS--------YGLMGEIGDAVIG-------------------------- SLNIEKY-HLAWS--------SSLIGQIGDGVIG-------------------------- ------------------------------------------------------------ NISPQST-MEMYV-----GDVTDILLMLFSRVYY-------------------------- --------TTRPX----------------------------------------------- SGCLEIV-STGLTSDESFSGFEQLQGIDNNTHIE------------------------SG F----TA-RTAQS--TTQKLLGNVSDLIIG------------------------------ SIISAHG-YLQVLPSETPNNHFRHDTNDQGMDVS--------------------DESIIG SGCLEIV-STGLTLDESFSELEQLQGIENSTLIE------------------------SG TGCLQIL-PSGLTFDEGFDNFTQLSRLENNARVI------------------------SG SRCLEIV-STGLSQQSRFSNFGQLEEIERDNYIE------------------------SG ESGFLVV-VPNTS--PRPHSSDFNFDQANEEIVS-------------------------G SIVSSSG-YLQIL--PNENANRHLHHNEVNVDDA--------------------DEPIGG AGFLQIL-PSDRE--SESSLSGPTSVYMRPTALD-------------------------- I-------LSTYE--ATFTKSVPLIGNVTDFIIG-------------------------- GDVPPHI-LSAAHVSELLHIRTSIMDYIIALGLLGF------------------------ ---------------------------YEW-----LRRSTPVYI--------LAALILFY ---------------------------YSGWLYF-KHSRMGLLV--------LVLFSIYL ---------------------------YCGWLIS-KNAHYWILG--------SVLLYLLI ---------------------------YAGWLQH-LKVHYLLVG--------LFLLYLLY ---------------------------YCGWLVT-KNVHYWILG--------SLLLYLLL ---------------------------YCGWLLT-KNAHYWILG--------SILLYLLL ---------------------------YCGWLIS-KNAHYWILG--------SILLYLLL ---------------------------YCGWLIT-KNAHYWILG--------SVLLYLLL ------------------------------------------------------------ -----------------------------------APTIFDLVV-------LTIFLCLVL ------------------------------------------------------------ PTAIYLKPTKLDLLIHTLVTPFMDTTIYGLWFGTTSEGRLVLLI--------FALLCFSL ---------------------------YSGWL---YVAYGPLLP---------LLAGLFG ATQIYMKSTVLDRLIQGYIRKISDFSIQGLWFSSTSKGRLALLL---------VALFCWG PTSIYLKPTKLDLLIHTIVTPFMDTTIFGLWFGTTSEGRLVLLI--------FILLTFSL PTTIYLKPTRLDYIKQSLIRPIVDLIIYGLWTTMTRNGRLCLGL-----------IAIIA PTSIYLKPTKWDFFTNKVITHLSDNIIYGLWLGTTAEGRMLSFM------SVLFLVALWY PTLTFMKCTSLDKINQIFFRRVSDLFIYGLWFGTTPKGRLSLLG-------FTLLMWVAY PTQIYMRPTKYDYIIQNYVRLVPDFLIYGLWFTITRTGRLILLV-------LALVLGGAY -----------RLIQRLVRPTVDTT--IAATLAGTTQPRGRLAV-------LGILLVMFG ---------------------------YTGWYIN-LEWYYLLLS--------LVILFIII -----------------------------------TTRMGWISI-------AGFLLFAWA FFYNLL------------------------------------------------------ WAS--------------------------------------------------------- RIL--------------------------------------------------------- IFFI-------------------------------------------------------- KIL--------------------------------------------------------- KNV--------------------------------------------------------- KIL--------------------------------------------------------- KIL--------------------------------------------------------- ------------------------------------------------------------ LALFRLTV---------------------------------------------------- ------------------------------------------------------------ WYLF-------------------------------------------------------- LSLICFHVIN-------------------------------------------------- AYYVI------------------------------------------------------- WYLF-------------------------------------------------------- WLAYAL------------------------------------------------------ LW---------------------------------------------------------- YILSK------------------------------------------------------- RYLV-------------------------------------------------------- LYLMKRG----------------------------------------------------- KLL--------------------------------------------------------- LYR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MLVKGSTK-----FLMAHRHDSMLL------NKIRCYATTDDNNLVSVL -------------MRSVVLFSGKRIGKLMTPFLLPRCDSRTRRFIRCAHSVNDNDIHF-- -------------------MLHHKLVYPVIFKWRIPFLGSSPTFTASYATVDGQNGNKPI ---------------------MFKFMCACRPVSRATYPRATLNFHRLYAMIAKGPSSRVI -------------------MLHHKFVYPFLFKWHLSCVEKCPTFIAKYATANDKNGNRTI -------------------MLHNKLVCPVIFRRRLPCTEKFPTSIAKYATVTDQNSSGPI ------------------------------------------------------------ --------------------------------------------------MNDQSSNKPI ------------IQVTFMICVGRNFI----------------PQTRRWASHMNVESDNHI -----------SLDGQQSSTDKISIAKALTRSLSVMLSRPTAARWRVSLTASGRSTVRWQ ----------------------------MLSLSRTNPLKG--LLLRRYATFPKPEDKN-H ------------------------MLSLLQKRIAVTINSNLAISKAHYATASQEPIDHRF -----------SLITRTFY-----------------------SNGSVFKRMASHSTNAPV -------------------------------------------MVRTYATASEPIDHHKN ----------------------MLSLLQKRIAATINCNTA--INKAHYATASQEPIDHRF -----------SIQRKSLTCNNSNYNKSSSSSLNRSS-----RFAKNYATLADGPVDHRL -----------LLPKIKKKPLKFAHSFSFTNSSPPIMLGRIRRQRCCYATAASEDPVDRL -------------------------------MSRVSTTR---IFCRLYATESSLPKVDHY -----------------------------------------------------------M -----------CLYKQLSK-----------------------TAARTYATAAIPHDEYKY -----------MLCSTALR------RIPIEVDRRVILNRGKVILISKFHSESGSEPGY-L -------------------------------MNRIKAPGGAPNIHTHFVLLRSRAFSSTQ HDSLWPDKHNPTPYEIFGFGVGLKKLKMEYHKYVKMYHPDLSSHAMEIAQYLTQAEKIQR -DSNWPKDNPKSPYSLFELTESKALLKKRFHELARLYHPDHSSNLTSSNNVLSTSDKSDR RDDQWPQLKEPSPYDIFGISKTTKSLKKKYHRYVKLYHPDHSDNTDSSSLLLTSSEKLHR FDNKWPNNKNPSPYDIFAIAEPKKAMKKLYHHYVKLYHPDRCGNKNPSLQMLSQAEKIRR RDEQWPELADPTPYDIFGIPKAKKSLKKKYHRYVKLYHPDHSDNTNSDSLLLTSSEKLHR SDKQWPRLKDPTPYDIFGISSVKKSLKKKYHRYVKLYHPDHSDNTDSSSLLLTSSEKLHR ------------------------------------------------------------ RDEQWPQLTDPTPYDIFGIPKAKKSLKKKYHRYVKLYHPDHSDNIDSNSLLLTSSEKLHR FDSEWTQEKNPTPYSVFGFRESRKQLKKRYHGFAKLYHPDISDSRSPSPDSISSEEKLQR GGLSWPQGKQPTPYEVLGLVKTARQLKKRYHELAKLYHPDTAGA-----QGLGEHERLRR RDDMWPSTKTPTPYEVFGVPPGPNDLKKKYHALAKLYHPDISNNITGDSPTLTTADKLYR QLHEWPKSAKPSAYEIFGLTSKNKVLKRKYLALVKIYHPDTSLSIQYKGGEMTAEMKRKR FDSAWPKGSCPTPYEIFGMPPGSRSLKKKYHAMAKLYHPDISNGQMDESAVLSAQDKMNR NLQPWPTSKKPTPYEIFQIDPKNKILKRIHSNYVKIYHPDISSNLDSKQQPLTLQMKRDR HLHEWPKSAKPSAYEIFGLTSKNKVLKRKYLALVKIYHPDTSLSILYKGGEMTPEMKRKR DLHDWPSSKNPTAYEVFGLTSKHKIIKQKYVKLVKLYHPDTSLDIDEYGDKMSEKTKRKR GLHEWPTSSNPTAYEIFGLSSKNKILKKRYVSLVKIYHPDTSLVLKHKGKEIDTDLKRKR GLHSWPRSKKPTPHEIFNVTADEKSLKATYQKFIKLYHPDRCATIDGAGKALSATQKRQR NLHPWPNKRNPSPYEIFDLSDGNKLLKKKYVSYVKLYHPDLSKNIYHKGSLLSENIKRQR DLHPWPKSKKPTPHEIFNLDPSNKILKSCYVKYVKIYHPDVSKNTDDKGKQLTEEAKRQR HDSLWPNNNNPTPYEIFNLKGTNKSLKKIYHKYVKLYHPDMSCNRNVSGRLLSIEEKLER KCMDYPAHDNPSPYEIFGMGPHQKALKREYYILAKKYHPDSNGSSEET-ADLTKEIKDAR FKLVTQAYEILKDPRKKNLYDCTRSGWDMAGSAGPTGA-QSAYNNFSDQSYAYWNAGNWE FKIIKEAYELLKDPGRKHQYDMLGLGWVYGPKPIPTASGMPRY----ERHEKFYNAGTWE FKVISQAYDILRDPKKKIVYDTTRQGWSTPF--SPSSNVTENYGYHSNAQYEYWNAGTWE FKLVSQYYAILMDSNKKRQWDFKNAASGTHM--------NNVN---MNANYKYWNAGTWE FKVISQAYDILCDPKKKIVYDTTRQGWTTSY--SPRSNVTENYGYHSNAQYEYWNAGTWE FKTISQAYDILCDPKKKIVYDTTRQGWNTPY--SPSSNATENYGYHSNAQYEYWNAGTWE ------------------------------------------------------------ FKIISQAYDILCDPKKKIVYDTTRQGWTTSY--SPRSDITENYGYHSNAQYEYWNAGTWE FRMVTNAYEILNDDSKKRLYDHTHSGWSY----GPQGSRNNGFGYKSNATYAYYNAGTWE FKLVNEAYALLSDASRRRMYDMYATGWAHGP--APMAPAHGAY----HERYAYYNAGTWE FKVLNEAYDLLTDSRRKGIYDRYKTGWSHGPHVSSYASSSNDY----HSNSDYWNAGTWE FDMIQEAYDILKNPRRRTAYNRYTTSWDQQGNGGQWSKEFEAYRYNFENDEQFWSASTWQ FRIMSEAYELLSDYRKKSTYDRFRSGWDY----GPVGNS-DSYGYHQNHHYEYWNAGTWE FDQIMTAYELLKDPRRRTAYNRYGTSWDSYL--------STSWKYKFENDEEFWRAGTWE FDMIQEAYDILKNPRRRTAYNRYTTSWDQQGDGGQWSKEFEAYRYNFENDEQFWLASTWQ FDLIQESYDILKNPRRRGAYNRFTTHWEQQGERGPDGQPTASFRFDFKRNEEFWSAGTWN FDMIQESYQILKNPRRRIAYNRFTTTWEQQGDKGPWSKEFEAHRYDFKHDEEFWHAATWQ FDEIQNAYDILKDPSQSVAYQRYNTTWGSY-QRGKTDS-FNAYKYSYHQDPKFWQAGTWE FDQVQEAYDILKDPRRRVAFRRYTNNWDEAPNTAPFSKQYEAYSKSFKADEEFWLAGTWE YDEIQYAYDVLKDPRRRVAYNRYSTAWENYGNPNPSS--FEAYKYDFKEDEQFWKAGTWE FKLISHAYEILKDKDKKFLYDCNKSGWVNNGYPNAYS--TKHYGYQSDYTYAYWSAGTWD FRKISNAYEILKNPSRRHAYDRFGQGWEGAR-PGPYGQDTSNLRYSTQSDG-FWGASGWQ DVHNYQNNSG-------QKLDPWTLLMWFGGLLLCLEGSSLLARIEDTLTDKSITEDNIE DYSNIRRNDK-------EEVGPLSMLIWFFGIFAIVELTSLLSRLEESINKRDFAHDETE DANSMRNERI------KENFNPWTLIAIVCGLAICIEGTALLTKIQESLSKADFTHEESE DVNSYYKETN--EGGLEKKLDLWVLFCWVSGLYVCVQGYALLNRAQESILNKDTDHDEIR DANSMKNERI------QENINPWTVIGIICGLAICIEGTALLAKIQESLSKAEFTHDESG DANSVKNNRI------KENFNPWTAVGIVCGLAICIEGIALLEKIQESLSKADFAHEESE ------------------------------------------------------------ DANSVKNERI------KENLNPWTVIGIICGLAICIEGTALLTKIQESLSKAEFTHDESE DLNDLGKEDR-------AKLDPWTLLLWVCGLAICFEGTSLLSRSEDTIVGKHFTQEQTE DMQDLNSDRQ------QVQFSAWGMVVWALCMLAGFQVMAFLIRLEERTSKSAHTHEEAE DVNNLGKTDQ-------KKISAWMILAWMCGLFVCVEFTALLTRIEETINQKNFTHDETE DYYQMKYNRPPPTKEEKNKYKILFGVIAVGVLGFGLQIMNAIDKTNQYLLETHRLNMKSM DVNNLKRSPE-------NKVSVWAVVGWVCGLFVCIQCTALLTRIEESLTKVHYTHDETE DYYKMKFKRKPPTKENKNKYKILAGVLAVVGLTSGLEVMLALNKTKEVQRQNTLLNLRSM DYYQMKYNRPPPTKEEKNKYKILFGVIAVGVLGFGLQIMNAIDKTNQYLLETHRLNMKSM DYYQMKYKRPPPTKEEKNKYKILAGVLAVGFLAFALQIMGAIDRTNQYLAETHRMNLQSM DYYQMKYKRAPPTQEDKNKYKILAGVLLFGAVGFGLQMINAVDNANKYLLETQQLNLKSM DYYQMRYGRSAPTREEKNKWKILWKVLAVASVVVALQIMLAVERTAEFNRQIRMMNLRSN DYYKMKYNRAPPTKEEKNKYKILAGVLLVALLAFSLQIMLALDRTNEYLLQSRLTNLQVM DYYRMRYNREAPTEENKNKYKILVGVLAVAAIVVTLQVMTALENAAQFRRRAEMRNFTSG DVQELNREKE--------SFNIWQLCIFVCSLYACVKGVALLSELEDAINMKSPSQEDSE DYEDLRNHSS---KANENTTLIGMALVVVAVVVTYLQIKRIIDVMEDQYFRVKEQNKKLE VELGQCYINYGLDTDKWSRLRRFLWFRTFNMYRSKVDLDREAEKNEDLIKTLQEKVK--D KHLTLAYINYGLDEDKWSRLRRFLWFRTYSLYRTKEDLDREAKKNENMIKDLKKKEET-D LHLIQSYTNYGLDTDKFSRLRRFLWFRTWGLYKSKEDLDREAKVNEEMIRKLQTTK---D TELFKAYNNFGLENDKWSRLRRFLWFRSWAM-ASPNEYDKEHYANEKMINDLLKKER--D LHLIQSYTNYGLDTDKFSRLRRFLWFRTWGLYKSKEDLDREAKINEEMIRKLKAAK---D LHLIQSYTNYGLDTDKFSRLRRFLWFRTWGLYKSKEDLDREAKINEEMIRKLQTTK---D -----------------------------------------------------------D LHLIQSYTNYGLDTDKFSRLRRFLWFRTWGLYKSKEDLDREAKINEEMIRKLQTTK---D NDLVQSRINYGLETDKFNRLRRFLWFRAFGLYRSKDELDREAIKNERMVQNSKNKERER- HALLLAHLNYGLDQDRVSRVRRFLWFRSWGLYRTKAELDEAARTNEALVRQLEGGK---D KDLTQAYINYGLDTDKWSRLRRFLWFRTFGLYKSKADLDREAKKNEELVQFLKSKAENED KDLNESYDNYGEGYSDADKLRRFLINRRMKSKREEEEVEKEPESDHELLTKFARKRVDID RDLGLAYMNYGLDTDKWSRLRRFLWFRTYGLYRSKADLDREAQNNERIVQELKSKEMQND QDLQRSQDNYGEDTTRFLRIRRFLLQRRSAFVNADDANFEKLKEDSRVLRKYAQQQVDKD KDLNESYDNYGEGYSDADKLRRFLINRRIKLKREEGEGKEPEPSDHELLTRFARKRVDID KDLNQSYAGGAGNYSEAENVRKFLISRRIRLKQEEKRNDGSDIAEREELMRYAKGRVNKD KALNDSYDNYGQGHSEADKVRRFLANRRSTMKSKQDHDDEEKLNDDELLRRYAVKRLESD ADLSEAYNNYDEGQTRFQRIRRFLLYRRSGLETRDDDGIKK--EENEMLTKYAQRKVAAD EDLQHSTDNYGDGLQPLDRMRRFLISRRLLMKEKGDIVDDTDLQDDELLIKYAQKVEK-N TALSQSLDNYGQGTTPISRLRRFLTSRRLADRTDEQTLDELRENDQEIVRKYAQQRLASD RDLILSYTNYGLDTDKMSRLKRFLWFRTFSMFRTKEDLDREVAKNNKLLAELEKPKKQKD DSLFWARNNYGFAQGKDDRVSRFLVMRRWRRRKIAEKRAKQAEVHGKLPVRPPPTALEVD YKEEQEQELEVLRSIYPDELEVVKEVKFELQLKLELSHLSKDHTLHCTFQLPEEYPDVNP YKEEQTQELEILESIYPDEFTVLNSIELQIDIKLDPDSITNDHILHTIFTLPENYPDEAP YKEEQAQELEVLESIYPDELRITNNIKFEVDIKLELSPLTKEHIITAEFKLPENYPDEPC YQEEQVQELEVLESIYPDELTINKGINFEVLLKLELASLTKQHSMLISFYLPEKYPDEAP YKEEQKQELEVLESIYPDELRIINDIKFEVAIKLELSVLTKEHTIIAEFKLPENYPDEPC YKEEQRQELEVLESIYPDELRILNDIKFEVDIKLELSPLTKEHTIVSGFKFSENYPDEPC YKEEQNQELEVLESIYPDELRILNDIKFEVDIKLELSPLTKEHTIIAEFKLPEKYPDEPC YKEEQKQELEVLESIYPDELRIINDIKFEVDIKLELSVLTKEHTIIAEFKLPETYPDEPC ------------------------------------------------------------ YQEEQKQELEVLESIYADDLTVVCGIQFEVDLKLDLAAISKEQHLVVDITLPERYPEEAP YKEEQIQELEVLESIYPDELTQVSSIHFQINLKLDLHSISNDHYLLLDIKFPEEYPDVAP PIEEQAQEIEVLQSIYPDELTLINNTHFIIRIDLD-TPSKRKHSLNLIVKYPPTYPEVIP YKEEQIQELEVLESIYPDELTTICQVQFSVRLLLDLDSVSWDHYMVLNFKLPETYPETVP PQEEQQLELEVLESIYPDELTKYSPTHFSIKLSLD-TPSNRKHRLLLDVRYPAEYPEVVP PIEEQSQEIEVLQSIYPDELTIIDNTNFIIRIDLD-TPSERNHSLNLHVKYPPNYPEVIP PAEEQAQEIEILQSIYPDELEFLNDTQFQIQLNLD-VPSERRHGLILVVKYPASYPEVIP PVEEQLQEIEVLQSIYPDELELINNTHFSIRINLD-VSSTRKHSLKLIVKYPETYPEVIP PLEEQKQEIEVLQSIYPDELELVSPTQFSINVALE-TVSDTKHTLVLGVEYPPKYPEEAP AEDEQREEVEVLQSIYPDELVVISDSHYKIRIKLD-TPSTRVHTLALDVRYPATYPEVIP PLEEQQQELEVLESIYPDELTKISDQKFSIHIALD-TPSETKHTIILHVKYPPEYPEVVP YKEEQQQELEVLESIYPDELNVLSDVQFEVSLRLELVQLNKEHTMMVNFQLPENYPDAAP PLEEQQQELEVLQSIYPEEITVLDPSTYTIDIGLD--VQPKGQCVELHVKYPKDYPEVVP VISIEVEENIPDTISIADYVSGLVAELEEQIETDSGMQMCFALISSIKEKAEHYFLEQLT LIKIMPEENIPDKIHFDEFIPQCIEKLNEQIQEDLGMQMCFALISNIKDYAEQWFQEKLS TISLEAQQNLPDTVSFKGYLPELTVKLETQIETDLGMQMCFALISSIKENCEQWYSEELG TIKIQPQENLPDKISFQQYIPDLQVKLEEQIEDDIGMQMCFALISSIKEHCETWFSEQLH LISLEAQENLPDLISFKGYLPELTVQLESQIETDLGMQMCFALISSIKERCEQWYSEQLN MISLEAQENLPDMVSFKGYLPELTVQLETQIETDLGMQMCFALISSIKEKCEQWYSEQLN MISLEAQENLPDLISFKGYLPELTVQLETQIETDLGMQMCFALISSIKERCEQWYSEQLS MISLEAQENLPDLISFKVYLPELTVQLESQIETDLGMQMCFALISSIKERCEQWYSEQLS ------------------------------------------------------------ QLSIRPWENIPDSISFDGEVDGFASQAMRQVEEDLGIQMCFALISSIKEDAESWFQKELE LIEITAEENLPDKIHFDDFIPTLLSKVDGQVEDDLGMQMCFAIISNIKETSEAWFQDTLT QLSIELALNMAETIEFKTDLNDLMNKLLEESELNLGIPMIFNLITILKEESENLFNEKLN EISIECESNLPDQVEF-DDHARLESQVESQANEDIGMQMCFALVAWIKESCERYFQEKLA ELDIIIPLNLSETIEFSQDINQLVSKLIEEADLQVGMPSVFALATQLKDEAEFLFQNKLE QLSIEIALNMAETIEFKIDLNDLMNKLLKESELNLGIPMIFNLITILKEELENLFNEKLI DLRVEIVLHMAETIEFREDLSKLLSKLNEEAELMLGMPSIFTLATVLKEEAENLFESKLD NLQIEIALNMAETIEFRNDFNELLNKLNEESELNLGIPMIFSLITLLKEEAESLFENKLN RLNIKAFVSLAETIELKTDLAQLLAKLQEEAELNLGMPSVFALVALLKDEAEILFQQKVD DLDVELALNMSETIEFKKDLEILYEKIIEEANNQIGIPMVFALASQLKDDAEQLFKDNLD ELSLEAEGDLGEFVRFSADIRTLLLKIEDEAAAQIGIPSVFALTSQLKEEAESLFQAKLT IISIEAQETLSDNISLSGYVPELQVQLEEQIENDLGMQMCFALLSTVKDNSENWFHERLS VIRIVRGDYEGEPVFLAEDYAELTSKMQEVAEENVGMASVFAIASSLKDEAEELHASKVR LKQKQHDQELQEREKEEQAKFHGTKVTRESFLGWRTKFRQEHGLDKRDEERRLQAHHRLT ELEKEHDRLLLEREKEEQKKFRGTKVTRESYIEWRAKFRKELGLDERDAQRRLAAHQRLS KLEKQHDWETQEREKKEQAKFHGTKVTRETYLEWRSSFRKELKLDERDQVRRMKAHHKLT ELDRQHELEIQKREKEEQAKFNGTKVTKDSFIEWRLKFRKELQLDTRDEMRRLQAHHRLT KLEKQYELEAQEREKKEQAKFHGTKVTRESYLEWRSKFRQELKLDERDQVRRMKAHHKLT KLEKQHDLEAQEREKKEQAKFHGTKVTRESYLEWRSEFRKELKLDERDQVRRMKAHHKLT KLEEQHDLEAQEREKKEQAKFHGTKVTRESYLEWRSKFRKELKLDERDQVRRMKAHHKLT KLEKQCEMEAQEREKKEQAKFHGTKVTRESYLEWRSKFRQELKLDERDQVRRLKAHHKLT ------------------------------------------------------------ RREKEHERQLRERELEEQKKFRGTKVTHESYMSWRASFRQELGLDERDQERRMQAHLRLS ELEKEHERKLLDREREEQKKFRGTKVTAESYLAWRTKFRKDMGLDERDNQRRLDAHNRLS IKQCEFDEQQKIKELNEQKKFHGTKVTKQSWLNWRNNFRKEMKYELYDKQRFENMHKKLT ELERNHEQKLLAREREEQKKFRGTKVTADSYLEWRARFREEMGLNERDAARKSQAHGKLS QTQKKYDADSLAKEMEEQKKFHGTKVTKDSWNEWRTKFREEMKVAEKDLENFNKMHNKLS LKQNQFNQQQKIKELNEQKKFHGIKVTEKLWLNWRNKFRKEMNYELYDKQRFEIMHKKLT AAEKEFEKRRNEREKVEQQKFQGTKVTPENWLEWRNKFRAEMQVDKKDELRKQEMHNRMT LKNQEFELKRREKELKEQQKFQGTKVTIESWTKWRNDFRKEMKFEEIDKQRFIKMHNKLT SAQQEYDEKLLAQEREEQKKFHGTKVTKESYAEWRKKFREEMQFELKDKKRYEEMHNKMT SKQAEYDRELLERERIEQQKFNGTPVTKESFAAWRDKFRKEMNYEEKQRQKFRAMHQKLT KAQKEYETKLLAQEMEEQKKFHGTKVTKESWTKWRENLRKELKIDEKVAQAYQEMHGRMT ELEKEYEKQLEAREKEEQAKFNGTKVTRESFLNWRGTFRKELKLDERDADRRLAAHHRLT SNEQKLEQARKAVEDEEQKKFVGTPVTPESFAEWRKGFRAEMGLDNIEAE-KVKARGKMT GKQMFEQGIEGT--LDDIDDTDVQEVATKLQD----------MTNIDSYG---------- GRQIFEQGLAGDEDLDEENESLISEGVKAIAV-------------------MLKRLFV-- GKQMFEQGVVGTGDEEDGSVDDVSKALAGTEL------MLPLKVLPKSFGFISRSQIRWI GKQMFEQGVDGTIDLDENEDESSISIVAKVTD---------------------------- GKQMFEQGVVGTGDEEDDSVDDVAKGLAKTEI------MLSFRSLTSTFGFVSRFQIR-- GKQMFEQGVVGTGDEEDGSVDDVAKGLAKTEI------MFSLRGLPNSFCFVSKSQIRWI GKQMFEQGVVGTNDEEDGTVDDVAKELAKTEI------MLSLSALANSFSFVSRSQIRRL GKQMFEQGVVGTGDEEDDSVDDVAKGLAKTEI-----MMLSFRVLTSSFGSVPRSQIRRL ------------------------------------------------------------ GRQIFEEGLAGE--EDVEGEDDIVQGIKQL-------------------MLGRFTRLLVA GKQIFEQGLDGG--DDAEVEEDLAEGIKKL---------------MQLQRYVARKALLS- GKQIFEKGLANQNDDEEEGENQTIQEQEKDIV----------------MLRVNTLSRC-- GRQIFEQGLDGSEDVEEE-------------------------MICRSFVNPACTPFL-- GKEIFEKGLAG---DDEDILNDITDNVKNVTV---------------------------- GKQIFEKGLANDETKNKDKDKDIVEGIKRL------------------MKFMRPLPFYRF GKEIFEKGLAKEGDETNGDQDKLAEGVSKVTV------------------MFIRTHLL-- GKQIFEQGLATTDEEIGQEQDGLIEGIKKI--------------------MIKRIPRTIQ GREIFEKGLAGTED----DLAELADAVAKTEL-------------MKLWRLSRAQPIV-- GREIFEKGL-----AHEEEVDDLAEGVKKVAV---------------------------- GREIFEKGLAGN-------EDDLEAEVAAIAI-----------------MFSIKLPLVGS GKQMFEQGVDGTTDEDE--VDEVVDNLSKTNV---MLTTTNLKPCFRWYRCLSQTSLIN- GKEIFEKGLGGE--EEEEDMAGLALE---------------------------------- ------------------------------------------------------------ -----------------------------------NRFFST-GRTLFY------------ RTNLPVPNS--------------------------KVRDDPSRGRVAAEKK--------- ------------------------------------------------------------ --------RLGTSLSIQNLE---------------VQDGRW-KGKLATEKK--------- GTSLAVQNLK-------------------------VRDDRW-KDKLAAENK--------- GTSLVVQNYK-------------------------VRDDCW-KDKLIAEKR--------- GTSLLIQNSK-------------------------VRDDRW-RDELAAEKE--------- ------------------------------------------------NTK--------- T----------------------------------AQGYRY-ASNSASAKPI-------- -----------------------------------FRCLFS-SFPRLAEKS--------- -----------------------------------LKEVRF-TRPLPFYRF--------- ------------------------------------------SRLLSYTSR--------- ------------------------------------------------------------ HS----------------------------------------STTTSSSSS--------- -----------------------------------IKQLRA-RTPLLIT----------- LARFQR-----------------------------LPICRF-NSTVPIKSE--------- -------------------------------------WARM-NSVLARPPK--------- ------------------------------------------------------------ -----------------------------------LKALRP-KSLIYI------------ -----------------------------------QCNFRI-SAKRCYSEQ--------- ------------------------------------------------------------ -----------------VKTTKFTKG---------------------------------- ------------------------------------------------------------ ------ADKDGSPMDTKIKTMKTLTN---------------------------------- ------------------------------------------------------------ ------TNREHKSVDTNIKTMKMLKN---------------------------------- ------IDKGSKPMDTKIKTMKTLKN---------------------------------- ------RIKENKPVNTKIKTMKTLKN---------------------------------- ------TNKRNKPVDTKIKTMKTLKN---------------------------------- ------NEXQSRLDDLNVRTMKSPRS---------------------------------- ------------------------------------------------------------ ------LKAVDTNVKTAKSPKGTDKP---------------------------------- ------NSSSTTTTTTTSSPPSVSVTNIKRA-TKNIPKKKI-GAQKLR------------ ----------TGQIKTVKAARSSLSA---------------------------------- ------------------------------------------------------------ ------SSSPSLPITNIKRASKNIPKKKIGAQKLR------------------------- ------LHRSNSSITTKIRGSKNLPKKKIGAQKLRRADPKF------------------- ------NKPINRVKNVPKKKIGAQKL---------------------------------- ------KPLKPNLHTLRRSNPND------------------------------------- ------------------------------------------------------------ ------ERFVSTAAATKTKKKINSPLQN-------------------------------- ------KTIEDDIPYIRMKMVRSPRSI--------------------------------- ------MRRFSTSVWQYTRASELGVKVKSFQ----------------------------- -----------------------------------IANPTRYLRRSFVP----------- --------------------------------AGPNPTAARSLRRS-------------- -----------------------------------SKNPTRYLRRSFVP----------- ------------------------------------------------------------ -----------------------------------PKNSTRYLRRSFVP----------- -----------------------------------SKNSTRYLRRSFVP----------- -----------------------------------SKNPTRYLRRSFVR----------- -----------------------------------SKNPTRFLRRSFVP----------- -----------------------------------SQNLSKNLRRAFVP----------- ---------------------------------------ARSLRRSVLP----------- ---------------------------------------VRNLRRTFLS----------- -----------------------------RTDDSKFQHESASYILSLLN----------- ---------------------------------------AKNLRRSVIP----------- ------------------------------------------------------------ -----------------------------RTDDSKFQHESASYILSLLN----------- ------------------------------------QNESISYILSLLN----------- ----------------------------RRTDNSQFQHESTNYILSLLN----------- ---------------------------------------ADSAILSLLE----------- ------------------------------------------------------------ -----------------------------LRRSTPSDNGNLTHILSLFN----------- -----------------------------------QQNPSRYLRRSFVP----------- ---------------------------------------SSKQALRRLP----------- --------------------------------RSK----K-------------------- --------------------------------RQL----K-------------------- --------------------------------NHR----N-------------------- ------------------------------------------------------------ --------------------------------NHR----K-------------------- --------------------------------NHG------------------------- --------------------------------NHR------------------------- --------------------------------NHG----V-------------------- --------------------------------HFN----L-------------------- ------------------------------------------------------------ --------------------------------KKH----S-------------------- --------------------------------ANR----Q-------------------- ---------------------------------------K-------------------- ------------------------------------------------------------ --------------------------------ANR------------------------- --------------------------------ENK------------------------- --------------------------------ENR----Q-------------------- --------------------------------KHS----Q-------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KYS----K-------------------- ------------------------------------------------------------ VNAVD-TESEDDK-FESSILKT-LVIKPCTTVTTGERYDLGKCLEILNINGF-QPSNLIP ------RPQTIESSLVT-------RIRPVTAITTAESYDLQKTIDLLSRKGYQPT----- ------EEREHDN-LKDVLSKEYLKMKNCTTITTGEGYDLKECIRCLKGQGYQPT----- ------------------------------------------------------------ ------QENGRDI-LEDSLSKDHLKVKSCITITTGEGYDLKRCMKLLTMQGL-QPTNLIP ------TKENGYDNLEDVFNKKCLKVKNCTTITTGEGYNLKECMRLLNSKGL-KPTGLVT ------IEENGHDDLEDFLSKKYLKVKSCTTITTGEGYDLKECMRLLGNQGF-RPTNLIT ------EEKGRDN-LEDVLSKKYLKVKNCITITTGEGYDLKQCMRLLNSQGL-QPTNLVP T-----RYNFRDD-LESV-SLKCLKVKSCTTVTTAESYDLSKCIALLHSQGF-QPVSLIP DGPWK-ITEDKSHPLAH-RVSKQMSIKPVTAITTSESYDLNKVIELLFQKGY-QPVNLIP MTGGNIYSNNFDS-FEQ-NLGSFLKIKPCTTITTGESYNLPHVIRILNSLGY-NPVSLIP ------ETPSPKE-LEK-------YLSIVTSVTVGDSIDFDKLLTQI--KGY-EYQIVIP ------QKAESLQNVGNVNLSSFLKTRPCTTITTGESYDLNKVINNLHTSGY-HPKSLVP --------------MPE------------------------------------------- ------QETPSPKELEK-------YLSIVTSVTVGDSIDFDKLLTQIKGYEY-QI----- ------EHVDAKS-LEK-------HLSIVTSVTVGDSINFEKVLPAIISLDHHV------ ------EEVSPKV-LEK-------YFNIVTSLTVGDAIDFDKLIPSIQGYEFQIVIPE-- ------SPVGPAE-LQQ-------HVRPVTSITVGGSINLGKVASILTSHGLNHR----- --------------IPD------------------------------------------- ------KNGAEDAKLEK-------YLSPVACVTVGDAFDLGKVRSLLGNECQKRM----- ------AQHLKKDWNVQ-NLSTNYKVKVCTTITTGERYDLSKAIGLLNLNGL-QPSNLIP ------SKKPQTQ-TPS-----PQTLQPCTTISTCESYNLPKTVELLHNEGFLQSS---- ----G-EIVSFN-YRT--------NGIDG------------------------------- -TLIPNEIISFK-YLH--------DGCRG------------------------------- -NLVTGEIVTFT-YQD--------NGVKG------------------------------- ------------------------------------------------------------ ----D-EIVSFS-YQD--------NGNKG------------------------------- ----D-EIVTFS-YQD--------NGTKG------------------------------- ----D-EIVTFS-YQD--------NGNKG------------------------------- ----D-EIVIFG-YQD--------NGDKG------------------------------- ----D-EIITFR-HHC--------NGSTG------------------------------- ----N-EIVTFK-YFY--------EGLQG------------------------------- ----D-EIVSFK-YLH--------NGHRG------------------------------- ----E-EVINIS-TST--------T----------------------------------- ----D-EIVTFKYFHN---------GYRS------------------------------- ------EVINVK-YNG--------K----------------------------------- -VISE-EVINILTLTT-------------------------------------------- -VISE-EVINIS-------------TPKS------------------------------- ------EVINISTSDS-------------------------------------------- -VVVEDEVL----------------SWGGRHES--------------------------- ------EVINVN-LNG--------K----------------------------------- -VIPDEVCAFQV-------------DSK-------------------------------- ----N-EIVTFK-YIY--------DGVRG------------------------------- -ILLPGEVAHVE-YPY---------EAGKIA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------TIMILGQT ----------------------------------------------------DIMVLAQN ----------------------------------------------------DIMILGQN ------------------------------------------------------------ ----------------------------------------------------DVMILGQN ----------------------------------------------------DLMILGQN ----------------------------------------------------DIMILGQN ----------------------------------------------------EIMILGQN ----------------------------------------------------DIMILGQS ----------------------------------------------------DVMVIGQN ----------------------------------------------------DIMVLGQN ----------------------------------------------------NLMILS-N ----------------------------------------------------DIMILGNS ----------------------------------------------------ELMILT-N ----------------------------------------------------NLMILS-N ----------------------------------------------------NLMILS-N ----------------------------------------------------NLMILS-N ----------------------------------------------------DVMVLA-N ----------------------------------------------------DLMILS-N ----------------------------------------------------TVMVLA-N ----------------------------------------------------DIMVLGQN ----------------------------------------------------DVLVLA-N GSVVCWGVDERTALIEIVPLIS----------EAIVNKLEVEEYETEDMDYIESAEDLE- GSIVSWGFNETVMRDEILPLVS----------TARVNSLLDSQYESEDLDYV-----EL- GSIVSWGFGESTVRDKIVPLVE----------GASINPLAKEDFETEDMDYVELAKKQDL ------------------------------------------------------------ GSIVSWGFSESSVRNCIVPIVK----------AASLNPLNGEDFETEDMDYVEGEQDFD- GSIVGWGFGESTVRNKIVPLVK----------AASINPLSEEDFETEDMDYVELEKKKDL GSIVSWGFDESSVRNKIVPLIE----------AASINPLSAQNFETEDMDYVELEKNQD- GSIVSWGFNEATVRNRVVPLVE----------TASINPLNGEEFETEDMDYVELKKKQDL GSIICWGFDEATVNQNILKLVE----------DARTNPLNPDEFESEDMDYVENKLQLE- GSVVSWGFDEASHKQHILPLI-------------DGNPLPQSLYESEDLDYV----EIES GSVVSWGFDETCLTENILPLIS----------PARVNPLAPKQFESEDMDYV-----ELE GTLVGWNLTEEEIVQ-FLPILED-----------DCIENKFDAFESEEIDWIKQQLPQDP GTVVSWGIDESFTLENILPLIQ----------SARINPLAENAMESEDLDYL-----EIE GTIVGWGLSESVIVKQIMPTLLPA--------ICDKCEPESEEIDWVELDYL----PDNS GTLVGWNLTEEEIVKFLPILQ-----------DCIENKFD--AFESEEIDWI-----E-- GTLVGWNLTEEEILNSYLPTI-----------QDAIEGRTEE-IESEEIDWI-------- GTLVGWNLTEDEIVNYLPVIE-------------GSIESKCETFESEEIDWI-------- GTLVGWGMTEAQMMKAHVPTI-------------MDAVQERCEPESEEMDFV-------- GTLVGWALDEETIIKTFIPIL-------------QSSILGRYDFESEEMDWI-------- GSVVGWGTPEDRLESDIIPKL-----------RSAVCVPESEEMDWIDLGYI-----PEK GSVVSWGFDENTLTNNILPLI-------------ESNPLVPDKYESEDLDFI-----ELD GSVVSWGMNESETEDKIVAMLKGA------------ERRPYKHHESEDVDFVPNEDNSQ- NLRSHSGIQSEPKI---NSRLIGDVILINSIEK--------S-E------------GILD ENEDDMNNLKRDYSINDESCVTNELIIINGVEHEK---------------------ALLD EKFFSGN-NEVKPRFVNESFLSGDLILINSLDADQ---------------------GMLD ------------------------------------------------------------ KLSSLDN-KVTPRIAC-ESFLSGDLIIINSLDS--------D-Q------------GMLD EKLFSGN-KNVTLKTVDQSFLSGDLILINSLDSDQ---------------------GMLD LEKYFNRNSKLTPKNADQSFLCGDLILINSLDSDQ---------------------GMLD DKIFSSN-NKITPKIAGESFLSGDLIIINSLDSDQ---------------------GMLD SVQLESANHAAVKYLE-TSLLVGDLILINSTDP--------G-A------------GLLH KEEWSQISSLVNVSGLEQSFIKEDLIVVDRTSG--------DK-------------DMLD NSIELEQLKSVTHKIDDGSFIEGDLIVINSTDS--------EQ-------------GLLD LNQGTSY-------------LHGEIMVIQGPTM--------E-K------------RLLD SIEDLERVRHTLSRSVDGSFVEGDLIVVNSIDPEL---------------------GLLD PNNGNSY-------------MQGDIMVIQGTNKDK---------------------ILLD LKQQLPQ----DPLNQGTSYLHGEIMVIQGPTMEK---------------------RLLD ELKEVPD----HPLNNGNSYLHGEILVVQGSSKEK---------------------RLLD ELKELPE----TPLNKGYSYLHGEIMIVQGPDK--------EK-------------RLLD DLDTNAS------------FMQGDILVLQSQQE--------EQQ------------RLLE ELDDLPK----NPLNNGNSYLQGEIMVVQGSTS--------DK-------------RDLD PPNYGNS------------YMQGEIMVLQGDNEDK---------------------KLLD NEDETTLKLLPSGDANEASFIAEDVIVINSIDQ--------TS-------------GLLD PMTEAPEATSNDDPAGHKSYMKGETIILRGPEK--------K--------------MLLD KAAFSSGLSRSTALAVLENAMERHISNTRIITEKISTGIKLKVKESDALKSIGRLFLIRG KAAFSSGISRSTRLAVLEVALDAHIEKTREFTESLSRGKKLNISEKAVLQSTGRLFLMRG KAAFSSGLSRSTNLAVLEEALEKHISKTRTITENISKGTKLNLKSSDALKSIGRLFLIRG ------------------------------------------------------------ KAAFSSGLSRSTNLAVLEEAMEKHISKTRTITENISKGTKLNLRSSDALKSIGRLFLIRG KAAFSSGLSRSTNLAVLEEAMERHISKTRTITENISKGTTLKLKSSDALKSIGRLFLIRG KAAFSSGLSRSTNLAVLEEAMEKHILKTRTITENISRGTKLNLKSSDALKSIGRLFLIRG KAAFSSGVSRSTNLAVLEKAMEKHISKARTITENISKGTKLNLRSSDALKSIGRLFLIRG KAAFSSGFSRSTKLAVLENAMERHIVETRIITEKVSKGVRLNLKRGDASKSIGRLFLIRG KAAFSSGISRSTMLAVLERNMEAHIESTRSFTELLSKGNRLNITEAEILKSTGRLFLMRG KAAFSSGMSRSTRLAVLEGALETHIEKTREFTELLSVGKKLNLTESDVLKYTGRLFLMRG MAAFAVGLSRSTRLSILETQLEDYLHLTKKNSEILANGKQITTTEHEFLKITGQLFLLRG KAAFSSGISRSTRLAILEELLEAHIEKTRKFTENLSDGKRLNLTESMVLRSTGSLFLIRG KAAFAIGLSRSTRLSVLENALENHIQLTRVNSEYLSEGKQIKTTESDVLKLTGRLFLLRG MAAFAIGLSRSTRLSILETQLEDYLQLTKKNSEILAMGKQITTTESEFLKLTGQLFLLRG MAAFAIGLSRSTRLSILEQQLDEFLEMTKQNANLLANGAKLTTSEHEFLQITGKLFLLRG MAAFAIGLSRSTRLSILEAQLEEYLNLTKQNSEILANGKQITTSEHEFLKITGKLFLLRG MAAFALGLSRATRLSVLEESLERHIRLTRENSEALSKGLRLDSKEEDILRMTGRLFLIRG KAAFAIGLSRSTRLSILENAFENHLELTKQNSESLAKGRKITTSESDFLQLTGRLFLIRG MAAFAIGLSRSTRLSILENALENHIQLTRKNSISLSKGHSISTNEHDVLKLTGSLFLLRG KAAFSSGISRSTSLAVLESALEEHINRSRIITESVSNGKKMNLNERDFLKSIGRLFLIRG KVAFSSGLARSTKLAALEESLERYIDSLKMLTDHLATGEKLRVTEREVLTKTGQLLQLRG RLNLYSELIET-PDLYW---SEPELEIIFKDVSRYLDISPRINILNSKLDYSTDECRAIL KLNLYSELIET-PDLYW---SEPQLEKLYRQISRNLDIQPRISILNTKLDYATDEARALM KLNLYSELTET-PDLYW---SEPQLEEIFKKVSRYLDIGPRINILNSKLDYSTDECRALI ------------------------------------------------------------ KLNLYSELIET-PDLYW---SEPQLEEIFKNVSRYLDIGPRINILNSKLDYSTDECRALI KLNLYSELIET-PDLYW---SEPQLELIFKNVSRYLDIVPRINILNSKLDYSTDECRALI KLNLYSELIET-PDLYW---SEPQLEEIFKNVSRYLDIAPRINILNSKLDYSTDECRALI KLNLYSELIET-PDLYW---SEPQLEEIFKNVSRYLDIGPRINILNSKLDYSTDECRALI KLNLYSELIET-PDLYW---SEPQLEKIFKETSKYLDIGPRINISNSKLDYSTEETRALM KLNLYSELIET-PDLYW---SEPTLETIYKQVSRNLDVPARISILNKKLDYATDESRALM KLNLYSELIET-PDLYW---SEPRLEKIYKQISKNLDIHPRITILNTKLDYATDESRALM KLNLYSELIDT-PDLYW---SEPTLEKIYYSISKILDINSRISILNRKLDYATEEQRAFL KLNLYSELTET-PDLYW---SEPQLERIYKQMSRSLDIQPRIAILNTKLDYATEESRAFM KLNLYSELIET-PDLYW---TEPTLERIYELISRNLDISPRISILNRKLDYATEEQSALL KLNLYSELIDT-PDLYW---SEPTLEKIYYSISKILDINSRISILNRKLDYATEEQRAFL KLNLYSELIDT-PDLYW---SEPFLEKIYNSVSKILDINSRISIMNRKLDYATEEQRAFL KLNLYSELIDT-PDLYW---SEPKLEKIYNSISKILDINSRISILNRKLDYATDEQRAFL KLNLYSELIET-PDLYW---SEPTLEKIYEAVSRRLDVSSRISIMNRKLDYMTEEQRALL KLNLYSELIET-PDLYW---SEPTLEKIYNSVSKVLDINSRIAILNRKLDYATDEQRAFL KLNLYSELIET-PDVYW---TEPTLEKIYESISRAMDVPSRISILNRKLDYATDEQRALL KLNLYSEIIET-PDLYW---SEPQLEKIYKNVSKYLDVVPRINILNSKLDYSTDESRALL QLNLYSELIET-PDLYW---SEPELERLYALISKNLDIGPRIGILNRKLDYASEVVAILK SLLNERNSSFLEWIIIYLITFEVIFELFHFYKSNQESTKRVEVD---------------- AVLNEKKGTRLEWIIIYLITVEVCFELYHFYEKYQELVADAENKTKAENHY--------- SLLNERNGAFLEWIIIYLIAFELCFEVYHFYQRYYLPQCTETTSNDPNLKEKK------- ------------------------------------------------------------ SLLNERNSTFLEWIIIYLIAFELCFEIYHFYQKYSSYCSEPTNDDLDATK---------- SLLNERKGTFLEWIIIYLIAFELCFELFHLYQRYSPQSLEPTNDDPSAD----------- SLLNERNSTFLEWIIIYLIAFELCFEIYHFYQKHFLHCSETMDKGLYTTN---------- SLLNERNSTFLEWIIIYLIAFELCFEIYHFYQKYSSYCTETANDDLDEY----------- GVLSEKKDV--------------------------------------------------- SVLNEKKSTRLEWIIIYLITVEVCFELHHFYERFFGGKPDAHASLQE------------- AVLNEKKSTRLEWIIIYLITIEVCFELYHFYEKYYLGI---------------------- SVLNEKKGTRLEWIIIWLILIEVCFEIFHFYEKYEEKQNKRLNVKEDR------------ AVLNEKKGTHLEWIIIYLITVEVCFELHHYYERYWLDEKESTK----------------- AVLNEKKSTRLEWIIIILIMVEVGFETFHFYERYSDKANNKNNDKPNE------------ SVLNEKKGTRLEWIIIWLILIEVCFEIFHFYEKYEEKQNKKKKTKEVLYDNE-------- GVLNEKKSTRLEWIIILLIMVEVGFEIFHFYEKYEEKKAEKGSKVKGEMTNEK------- SVLSEKKGTRLEWIIIWLIVIEVCFETFHFYEKYEEKQNGVKHD---------------- GVLNEKKSTRLEWIIIVLIMVEVCFETFHFVEKWPRNEEERV------------------ GVLNEKKSTRLEWIIIILIMVEVCFETFHFYEKYTESTSNTKEQ---------------- AVLNEKKSTRLEWIIIILIMVEVVFESFHFYESRQSHNETA------------------- AVLNERKSTFLEWIIIYLIAFEVCFELYHYYEKNYIQTEQSSTDKENKIK---------- AHMAEKQSVRLEWMIIVLIMIEVGFECIHFWEKYRTKDDVKVEIKVPDTYYPSA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MDADNIEDIEEQP--VSTIPEDV----------- ---------------------------MSELIIEEPPEL--GSGISNEV----------- ----------------------------MSEGAEETAGG--ASNIPIDL----------- -----------------------------MSAIEEEHVP--QSSIPEDL----------- ----------------------------MNQCAKDITHE--ASSIPIDL----------- ----------------------------MSQRAGEATKE--ASYISADL----------- ----------------------------MNHCTNDTANE--ASNIPPNL----------- ----------------------------MNKCVEDTTNE--ASNIPIDL----------- ---------------------------PDRSPTKQSAST--PAASDQGPHCPTLRANPYP --------------------------MSVKFSAEEVPQV--SSEISDEL----------- -----------------------NNTMAEVITTEEHGLD--LPTIPEEV----------- --------------------------MSTTTDTIDLTND--GSEKINEVDNIHEDTPVEE --------------------------MAETVAPDDDAIA--SSAIPEDR----------- -------------------------MNGEELVLNDTVENSDVSNVDMQSDKPDDVTVVEH -----------------------DKRNELENNHEDTLVE--EFAIDEKT----------- -----------------------MDEIETKSEIKPPVTD----SKAENLSAPVGETELGT -----------------------QEQNNDIEISDSKCTDQQTMSEDTEMVTEAEEPKEET ----------------------------MTSSTRDSSNALTSSSTPTMEDLPAADSPEVI ---------------------------MSPEDSEQTYID--DFT---------------- ---------------------------MEVEVIDGPEEA----HIDQET----------- --------------------------MIEVIMDEQPFEQ--SSAIPKER----------- ------------------------------------------------------------ -----------------------QTRYIH-WK-------------KNTKLLYDYLNTNST -----------------------QQRYTN-WK-------------KNTKLLYDYLNTNTS -----------------------QERYSH-WK-------------KNTKLLYDYLNTNST -----------------------QQRYSN-WK-------------KNTRLLYDYLNTNSK -----------------------QERYSH-WK-------------KNTKLLYDYLNTNST -----------------------QERYSH-WK-------------KNTKLLYDYLNTNST -----------------------QERYSH-WK-------------KNTKLLYEYLNTNST -----------------------QERYSH-WK-------------KNTKLLYDYLNTNST EVTDR------------------QQRYTL-WK-------------KNTKLLYDYLNTNSF -----------------------QQRYTN-WK-------------KNTKLLYDYLNTNST -----------------------QTRYTN-WK-------------KNTKLLYDYLNTNST SAIDEKTQQ----------------NYRV-WK-------------KNAPLLYDYLVTNSL -----------------------QQRYTH-WK-------------KNCKLLYEYLNTNNT SPIDQQTEV----------------NYRI-WK-------------KNAPFLYDYITTHSL -----------------------QQNYRV-WK-------------KNAPLLYDYLVTNSL GAPVEESLI----------DELTEKKYRI-WK-------------KNAPFLYDYLSTNSL DASLIDEQT--------------ERNYRV-WK-------------KNTPLLYDYLMTNTL HDADENENG-----SSSLIDKSTQHRYRV-FK-------------KNAPFLYDYLSTNSL -----------------------QRNYRI-WK-------------KNTPFLYDYLLTNSL -----------------------QDNYRI-WK-------------KNAPFLYDYLTTHPL -----------------------QDRYTT-WK-------------KNTKLLYEYLNTNSN ------------------------------------------------------------ KWPSLTCQFFPD-------LDTSSDQHRLLL--SSFTSSQLPEDESVYISKISTLKHLNW KWPSLSCQFFPD-------RTLTNDKQRILL--SSFTSQQLPQDESIYIGSISTMNHMKW KWPSLTCQFFPD-------LDTTLDEHRILL--SSFTSSQKPEDETIYISKISTLGHIKW KWPSLTCQFFHD-------LDTTSDTHRILL--SAFTSSQLPEDEAIYIAKLSTLKHLEW KWPSLTCQFFPD-------LDTTSDEHRILL--SSFTSSQKPEDETIYISKISTLGHIKW KWPSLTCQFFPD-------LDTTLNEHRILL--SSFTSSQKPEDETIYISRISTLGHIKW KWPSLTCQFFPD-------LDTTLDEHRILL--SSFTSSQKPEDESIYISKISTLGHIKW KWPSLTCQFFPD-------LDTTSDEHRILL--SSFTSSQKPEDETIYISRISTLGHIKW KWPSLSCQFFPD-------LDTSSDTHRLLF--TSFTSSQSPQDENVTIASISTSRHVPW KWPSLTCQFMPD-------LEVPTDKHRLLL--SSFTSSQLPEDEAVYISELSTMRHVPW KWPSLTCQFFPD-------LDTTNDQHRLLL--SSFTSSQLPEDESIYVSRVSTLKHLPW LWPSLSVQFFPDNDLGENKNEEQIIAQRILL--GTFTLG--QAIDHISILQIP----SFK KWPSLTCQLFPD-------LDLAGDEHRILL--SSFTSSQLPEDEAIYVARLSSMKHIPW LWPSLTVQFFPDADSNGSKSENEASMQRILL--GTFTLG--QSTDSISILQLP----YYT LWPSLSVQFFPDNDLDENKNEEQIIAQRILL--GTFTLG--QAIDHISILQIP----SFK LWPSLTIQFFPDNENPNDEKNSDVILQRLLH--GTFTMG-QSPVDSISILQVP------- LWPSLTVQFFPDNNNANNKEENETIAQRVLL--GTFTLG--QAIDHVSILQLT----SFK LWPSLSVSFFPDEASIAASPSSQLAFQRLLL--GTFTLG--QSVDSISIHQLP------- LWPSLTVQFFPDTSKTSSEDSDNIYFQRLLH--GTFSLG--LSVDSIQILQVP----VFA LWPSLSVQFFPDSVGSQESSDPETVAQRLLV--GTFTLG--KYTDSISILRLP----YYT KWPSLTCQFFPD-------VNTKNDSHRILL--SSFTSSLVPEDESLYITRISTLKHLSW ------------------------------------------------------------ SSLNNFDMDEMEFKPDPSVKL-----------PPKNLTTEVSIR-FPNGDCNRSRYLP-- SSINNFDMDEMEFKLDNSLKL-----------NDKTLEEEVRIT-YPDGDCNRCRYMP-- SSLNNFDMDEMEFKPENTTRL-----------PPSHLVNDISIF-FPNGDCNRARYLP-- ASINNFDMDEMEFKPENNIKL-----------PSKNLTNDISIR-FPDGDCNIARYLP-- SSLNNFDMDEMEFKPENSTRF-----------PSKHLVNDISIF-FPNGECNRARYLP-- ASLNNFDMDEMEFKPENTTTY-----------PSKHLVDDIRIF-FPNGECNRARYLP-- SSLNNFDMDEMEFKPENSTRY-----------PPKHLVNDISIF-FPNGECNRARYLP-- SSLNNFDTDEMEFKPENSTRY-----------PSKHLVNDISIF-FPNGECNRARYLP-- SSSNNFDMDEMEF----KPDLS--------TKLPPKNLQIQLTINFPHGDCNRATYLP-- SSLNNFDMDEMEFKVDNQAKL-----------PNKNLVETVRIQ-FPSGDCNRACYMP-- SSLNNFDMDEMEFKLDNSSKL-----------PSKNLIKELNIS-FPMGDCNGARYLP-- NLNQNIKINKLDFNPE-REEFELTT-------PSLNKTKTLQKI-NHLGDVNKVRYMP-- SSLNNFDTDEMEFKMDNSLKL-----------PPKNIVEDLRIK-FPAGDCNKARYCP-- NLNKNLTIDKLDYNHE-KEEFELTKI-------AKKKINVLQKI-NHWGDVNKLRYMP-- NLNQNIKINKLDFNPE-REEFELAT-------PTLNKTKTLQKI-NHLGDVNKVRYMP-- -TYTNLNKKIVINKLDYNQEKEEFELNLSQSSSSNMKPKVLQKI-NQYGDVNKLKYMP-- DLNKSIKISKLDYNPD-KEELELSTS-------SINKTKILQKI-NHIGDVNRARYMP-- -YYQNLNKCINIEQWNYSTEKEEFEL----STISKNKIHVNQTI-NHLGDVNKLKYMP-- DLNRNLRIDRLDFNLE-KQEFELATS-------VNNKFKVLQKI-NHMGDVNKVRYMP-- NLSRHVNIDRLNYHAD-KQEFEVTSA-------SSKKISTVQKI-NHLGDVNRARYMP-- ASLNNFDLDEMEF----KPDNSNIKL------PPKNLTTELVIR-FPNGDCNRARYLP-- ------------------------------------------------------------ -QNPDLIAAASS-DGSVYIFNKTKHGNSVLR------SKSSDD--FQARLFSAQNLDNFN -QNPDIIGTASS-NGSVYIFDRTKHGNKIST------GRK-----FEIECRN-NGDDEQD -QNPDIIAGASS-DGAIYIFDRTKHGSTRIR-----QSKNSHP--FEAKLFGTSSAD-VN -QNPDVIAGASS-HGSIYIFDRTKHGSLRMR-----QSKNLKP--YEAALYCIENVENTN -QNPDIIAGASS-DGAIYIFDRTKHGSTRIR-----QSKISHP--FETKLFGTSSAD-IN -QNPDIIAGASS-DGAIYIFDRTKHGSTRIR-----QSKISHP--FEIKLLGTSLVD-IN -QNPDIIAGASS-DGAIYIFDRTKHGSTRIR-----QSKISHP--FEAKLFGASSAD-IN -QNPDIIAGASS-DGAIYIFDRTKHGSTRIR-----QSKISHP--FETKLFGTSSAD-IN -QNPDLISTASS-DGSVYIFDRTKRGKS-----------------PISHLRG-------- -QNPDIIGAIAS-TGAVNIFDRTKHGTNRPK-----LLGSAASYEIQLSLGD----ADSA -QNPDVIAAASS-NGSIYVFDRTKHGLTRQK-----LHDGGSM--FELEFQS-SSLEEHQ -QKPNILASANN-LGNLVIYERTRHKSFKNT-----ILDDTDLSKVQVRLVN-KHIPSTT -SNPDLISSASS-NGSVYVFDRTKHGSARQK--L----ISGGD--PDHQIHCTSLEERQN -QNPDVIASSNN-LGNLVIYDRTKHASFKNS--LIGEDTEINK--PQLHLIN-EWNPSDA -QKPNILASANN-LGDLVIYERTRHKSFKNT-----ILDDTELSKVQIRLVN-KHIPSTA -QKPNVIASANN-YGDLIIFERTRHKSFQKL-----IVDDTQVNKVQIRLVNQVPTEQKV -QKPNIIASANN-LGDLVIYERTRHKSFRNT-----MLDDTEMSQVQVKLCN-KYIPSSA -QNPDVIASANN-LGHLSVYNRTKHSTIKTL--I--GEKEINE--PQLRLVN--NAHPST -QKPNIIASANN-MGDLAIYERTKHKSFKNS--LI-DDTDLNK--VQVYLKNSNSADVEG -QNPDVIASCNN-FGSVSVYDRTKHANVKTA----LADTDISP--PQLRLVS--TTSSHA -QNPDLIAAASS-DGSVYIFDRTKHGTAMHS----RQSGFTQSYQAKLAVNNSQSLNGEN ------------------------------------------------------------ EAVSLSWNKH-KEGILGVSYSQGQCNIWDV---KKFSRS-NILISQPELTVT-FDSNGCN ESLSLAWNYQ-LEGTLATCQSNGKVKVWDL---TKFDKSKQRMEIPERESV--MDANGVN EATSLAWNLQ-QEALLLSSHSNGQVQIWDI---KQYSHE-NPLIDSPLVSIE-SDASGVN EATSISWNLQ-REGLLASCYSSGQIQLWDL---KKYSNS-KLEMDTPLLNVD-FDALGVN EATSLAWNLQ-QEALLLSSHSNGQVQVWDI---KQYSHE-NPIIDLPLVSIN-SDGTAVN EATSLAWNLQ-QEALLLSSHSNGQIQVWDI---KQYSHD-NPIIDVPLMSID-SDGSSVN EATSIAWNLQ-QEALLLSSHSNGQVQVWDI---KQYSHE-NPIIDLPLVSIN-SDGSGVN EATSLAWNLQ-QEALLLSSHSNGQVQVWDI---KQYSHE-NPIIDLPLASIN-SDGSAVN ------------------------------------------------------------ EALSLAWNWQ-KAGIIASSYSNGLIKVWDI---TRYQKS-QPTISNPELRIL-QDKAGTN EVVSLAWNWQ-REGLLAACYSGGDVKVWDV---KKYSRN-FPVIDKADYTHN-ADPRGCN DIFAIDWNRN-SEGLLLSADMNGLVNLYDL------KKYESETLNESQYWEN--NAIGVN EALNLAWNWQ-QQGLLATCYSGGEVCVWDL---AKYDKA-SPTLIDPHSSLL-ADPQGSN DIFAIDWNKQ-KEGVIISANMEGNINLYDISKFS---KD-VQTINESQHFGN--SNIAIN DIFAIDWNRN-SEGLLLSADMNGVINLYDL------KKYDSETLNERQYWE--NNAIGVN EIYAMDWNKN-MEGLLVSANMNGIINLHDV---TKYNKL-SNSLKQERYW---QHGSGVN DIFAIDWNQN-KEGLLLSADMNGIINEYDL------SKYESQTLHETRYWE--NNAIGVN TDFAFDWNNQ-KEGVAVAGAMDGVISLYDIDSYT---RS-ENRIFSSWDF---LNGVGIN TDFAIDWNKQ-KEGTIVSASMNGEINLYDISNFK---DK-S-VVNESWYYHN-ESSTGVN DIFAIDWNRQ-QEGTIASGSMDGQMCVYDI---QKMQKD-NDEVQPIWST---SSESGIN EALTIDWNHQ-KEGHLVVAYSDGHVKAWDI---TKYKRS-DPVIKAPEYNYK-LDESGCN ------------------------------------------------------------ DLDWMPMHDSMFIACGESNKLGLFDMRNGEKEVNSISN---YKHEDGINTCKFNPGNSLL DVSWMVNHTSILASCGESNVIGLIDIR---QDTKMDTL-HRTTHTDGINAIEFNYKNDMI DVTWMPTHDSLFAACTEGNVVSLLDLR--TKKEKLRSN--RQNHTGGVNSCKFNYRNSLV DVNWHPSHDSILAASGESNIIGLFDNR---GTEILRSN--EKMHNGGINSCKFNSHCDSL DVTWMPTHDSLFAACTEGNAVSLLDLR--TKKEKLQSN--REKHDGGVNSCRFNYKNSLI DVTWMPTHDSLFAACTERNAVSLLDLR--TKKEKLKSN--CKIHGGGVNSCKFNYKNSLI DVTWMPTHDSLFAACTEGNTVSLLDLR--TKKEKLKSN--CRSHNGGVNSCKFNYRNSLI DVTWMPTHDSLFAACTEGNAVSLFDLR--TKKEKLKSN--CKKHDGGVNSCKFNYKNSLI -----P------------------------------------------------------ DVSWMVHHSSILAACGESNTIGLLDTR---APDAFKPT-KASPHTGGINALQFNYANDML DVSWMVNHASILACCGESNSINVIDTR--AQKGVLSSTKDTKHHSRGINSSQFNYHNDML DIEWFPTHDSLFCTADDNGWLKLYDTR---NQSAAVQN---ANIGNSVNSVACNPGYATG DISWMVNHDSLLAYCGEGNALGVLDTRITKQPPQSFSN---PHHSNGVNACQFNYYKDLL DIEWIPNHDSILTYVDDQGSIKLLDVRLPEHQLLVLQH---QKSNKGINSVSVNPGNQAC DIEWFPTHDSLFCTADDNGCLKIYDTR---SENSVVQN---KSIGNSVNSVACNPGYATG DIEWVPTHDSLFGVTDEAGNLSIYDTR---ELLQKPKI--QASFGTSLNSISINPNFPSI DIEWFPTHDSLFATADDAGSIKVYDIR---ADNSIVYN---KNIGNNVNSIAINPGYATG DIEWVPTHDSFFLSADDNGMVRLHDSR---KSDPSVSF----STGSAVNSLSINPSNSFC DIEWLPQHDSLFSAVDDAGFISLFDTR--EESKLVHRY---RLSEVGVNSISVNPGISHC DLEWVPNHDKLFLSASDNGVVQLYDTR---QQNALSTF----FHSCAVNSVSICPGQTTT DAVWMPEHNSLFAACSEDNRLSLFDTR---DESNIIDI-STSVHKGGINACRFNPRNSLL ------------------------------------------------------------ VASADTCGRINLWDIRKLD------QEPISTMQ-HGSSISTIEWNPNIGVVFASAGQEDG LCTGDSQGQLKIWDIRDFK-------EPIKEWEHDQDPISAIQWNPQIPQILATADQQSG LASADSNGRLNLWDIRKMN------ESPITTME-HGASISTLEWNPNFSTVLATAGQQDG LISGDSEGRINLWDLRKLD------GEPIKTLH-HGSSISTLEWNPNLETIVASAGQDDG LASADSNGRLNLWDIRNMN------KSPIATME-HGTSVSTLEWSPNFDTVLATAGQEDG LASADSNGRLNLWDIRNMN------ENPIATME-HGASVSTLEWSPNFDTVLATAGQEDG LASADSNGKLNLWDIRNMN------DCPLTTME-HGGSVSTLEWSPNFDTVLATAGQEDG LASADSKGRINLWDIRNMN------ESPITTME-HGASVSTLEWSPNFDTVLATAGQEDG ------------FEAQ---------------------------SSPNNNG---------- LCAADSNGGIALWDCRAFS-------KPLSVFN-HGDSVSALQWNPNLPTIVATAGQGDG LCSGDSTGRVNLWDIRDLE-------TPLKSLD-HGSSISKTQWNPNLSTILATADQSDG LATGDSNGVIKMWDIRNFD-------NSLSELHGHSDSVTQLKWNPKCHNILGSSS-SDH LCSADSAGRINLWDIRDFS-------SPIRSLDHHG-SVSALQWNPHHPTILATAGQDDG LATGDIDGMIDVWDIRSFG---SGNANSVYNIKKQHESITQLKWHPKYHNILASSS-SDK LATGDSTGVIKVWDIRNFD-------NSLSELHRHSDSITQLKWNPKCHNILGSSS-TDH IAVGDSKGVIHIRNLQNLN-------EPLYELKDHQGAITQLKWHPKFAQVLASSS-TDS LASGDSQGTIKTWDLRNFD-------APVGEIRNHTDSITQLKWHPKYHNVLGSSS-TDH IALGHGDGQIELRDIRSPS-------ECLYRFTPHTDAITQLKWHPKFHSVLGSSS-GDR IATGDSNGLIHVYDIRGIG----SEMNPIYSIQEQTESITQLKWHPRYHNVLGSSS-TDH FATGDSNGQIDIRDIRMAN--------SIHHITSHTDSITQIKWHPNHRRVLGSAS-SDK LASGDSIGNICLWDIRKKE-------TPINILD-HGSSISTIEWNPNLSTVLASAGQDDG ------------------------------------------------------------ LVKL--------------------------WDASV----------------------GKE LVKI--------------------------WDASG------------------------E LVKL--------------------------WDTAR-----------------------EE LVKL--------------------------WDVST------------------------- LVKL--------------------------WDTSC-----------------------EE LVKL--------------------------WDTTR-----------------------EE LVKL--------------------------WDTSR-----------------------EE LVKL--------------------------WDTSC-----------------------EE ------------------------------------------------------------ LIKI--------------------------WDTSR---------------------EPED LVKL--------------------------WDIAQ------------------------- SVKL--------------------------HDMSN-----------------------DS LVKI--------------------------WDLSQ---------------------PVDQ LVKI--------------------------FDLNT---------------------IEEE LVKL--------------------------HDINN------------------------- LVKI--------------------------HDLSI-------------------LENGKG SVKL--------------------------HNVAN------------------------- SVKL--------------------------HDVAN------------------------- LVKL--------------------------FDLEN------------------------- TMRI--------------------------FDVAN------------------------- LVKL--------------------------WD------------------------AGSD ------------------------------------------------------------ I----------------------------------------------------------- Q-------------EDSNAENN-------------------------------------- T----------------------------------------------------------- ------------------------------------------------------------ T----------------------------------------------------------- S----------------------------------------------------------- N----------------------------------------------------------- T----------------------------------------------------------- ------------------------------------------------------------ S----------------------------------------------------------- E----------------------------------------------------------- T----------------------------------------------------------- E----------------------------------------------------------- E----------------------------------------------------------- ------------------------------------------------------------ L-------------DTSVELNV-------------------------------------- ------------------------------------------------------------ ------------------EH---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ K----------------------------------------------------------- ------------------------------------------------------------ --------------------------------------FVHGG--------HMLGVNDIS ---------------------ML--------------LFVHGG--------HMLGVNDIS -------------------------------------IFTHGG--------HMLGVNDVS --------------------DEL--------------VFTHGG--------HMLGVNDIS -------------------------------------IFTHGG--------HMLGVNDIS -------------------------------------IFTHGG--------HMFGVNDIS -------------------------------------IFTHGG--------HMLGVNDIS -------------------------------------MFTHGG--------HMLGVNDIS -----------------SP-------------------IVKRG----------------- ----------------------L--------------LFVHGG--------HMLGVNDIA ------------------PGEEL--------------LFVHGG--------HMLGVNDIS -------------------------------------IFTHLG--------HMLGVNDFD -------------------------------------LFTHGG--------HMLGVNDIS ---------------------GL--------------IFTHAG--------HMLGVNDLD ------------DST----------------------IFTHLG--------HMLGVNDFD ------------DTN-HKRSATI---------------FQHLG--------HMLGVNDFD ------------NST----------------------IFSHLG--------HMLGVNDFD ---------------------KL--------------IFNHEG--------HMLGVNDFD ------------------S-SSL--------------LFAHAG--------HMLGVNDFD --------------------DKL--------------LFIHAG--------HMLGVNDFD ------------------P------------------VFIHGG--------HMLGVNDIS ------------------------------------------------------------ -------------------------------------------------WDM--H---DP -------------------------------------------------WSQ--H---DP -------------------------------------------------WDV--H---DP -------------------------------------------------WNL--H---DT -------------------------------------------------WDA--H---DP -------------------------------------------------WDV--H---DP -------------------------------------------------WDA--H---DP -------------------------------------------------WDV--H---DP -------------------------------------------------IRS------EP -------------------------------------------------WNY--H---DP -------------------------------------------------WNY--H---DP -------------------------------------------------WSY--A---DP -------------------------------------------------WDP--N---DP -------------------------------------------------WSL--H---DD -------------------------------------------------WSH--A---DH -------------------------------------------------WSF--A---DD -------------------------------------------------WSF--A---DD -------------------------------------------------FSH--H---ED -------------------------------------------------WSH--H---DD -------------------------------------------------WSL--H---DD -------------------------------------------------WNM--H---DP ------------------------------------------------------------ W-----LMASVSND-------NTI---------------------------QIW------ W-----TMCSVSND-------NSI---------------------------HIW------ W-----LMCSVAND-------NSV---------------------------HIW------ W-----LMCSVSND-------NSV---------------------------QVW------ W-----LMCSVAND-------NSV---------------------------HIW------ W-----LMCSVAND-------NSV---------------------------HIW------ W-----LMCSVAND-------NSV---------------------------HIW------ W-----LMCSVAND-------NSV---------------------------HIW------ ------------SN---------------------------------------------- W-----LMCSVAND-------NSV---------------------------HVW------ W-----LMCSVAND-------NSV---------------------------QLW------ W-----MVASVADD-------NSL---------------------------HVW------ W-----MMCSVSND-------NSI---------------------------QLW------ W-----MMASVADD-------NSL---------------------------HVW------ W-----MVASVADD-------NSL---------------------------HVW------ W-----MIASVADD-------NSL---------------------------HIW------ W-----MVASVSDD-------NSL---------------------------HIW------ W-----MIASVADD-------NSL---------------------------HLW------ W-----MVASVSDD-------NSL---------------------------HVW------ W-----LVATVGDD-------NSL---------------------------HAW------ W-----LMCSVSKD-------NSI---------------------------QIW------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------R-----------------PAKNIVSKPS------------------------- -------K-----------------PAANLVEQL-------------------------- -------K-----------------PAENLVGLEQP------------------------ -------K-----------------PAHNLVEQV-------------------------- -------K-----------------PAGNLVGHS-------------------------- -------K-----------------PAENIVGSE-------------------------- -------K-----------------PAVNLVGYS-------------------------- -------K-----------------PAENLVGYS-------------------------- ------------------------------------------------------------ -------K-----------------PAANLVQAK-------------------------- -------R-----------------PARNLVESK-------------------------- -------K-----------------PTHSVTDKFK------------------------- -------K-----------------PSQNLMTPK-------------------------- -------K-----------------PSSQIVKQYKSI----------------------- -------K-----------------PTHSVTDKFK------------------------- -------K-----------------PPLQVVESVNP------------------------ -------K-----------------PTHTVTNQFK------------------------- -------T-----------------PAHHLVRSYL------------------------- -------K-----------------PSHTITRKYNSR----------------------- -------K-----------------PVIKLATATS------------------------- -------K-----------------PAHNLVELE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MHEVITISVSQRANHLATQFFNCRETLLYDNTKDKV-N ----------------------MREIINVSVSHRSNHLITQFYNCLEPLLHDADQ----- ----------------------MHEVLTISVSQRSNHLTTQFFNIQEGYLNLSKEEQV-N ----------------------MHEIITLSASQRANHLTTQFFNCQEELLYTV--GEKPN ----------------------MHEVVTISVSQRANHLTTQFFNIQEGYLQLSKEQQV-N ----------------------MHEIITISVSQRANHLTTQFFNIQEYYLKLSKEEQV-N ----------------------MHEVVTISVSQRANHLTTQFFNIQEGYLQLSKEQQI-N ----------------------MHEVVTISVSQRANHLNTQFFNIQEGYLQLSKEQQV-N ------------------------------------------------------------ ----------------------MREIVTITASHRANHLITQFFNGQERALHERDEQAG-S ----------------------MHEVINVSVSHRSNHLVTQFYNCQEELLQYSRVNQPEN ----------------------MSEIITLSYGSICNNTVTHLYNTQESLISYTPSSKPNH ----------------------MREVLSIGVSHRSNHVLTQFFNGQEQLLHDAEAQ---N ----------------------MSEVINLSLSQRANHLLAHLYNNQEAHLPYSKTATVDY ----------------------MGEIITLSYGLLCNNTVTHLYNTQESLISYKPSSKANH ----------------------MSEIFNLSFGQFANNTTTHLYNCQESEIPYTSSASPYH ----------------------MGEVISLSFGQDSNHIITHLYNAQESLIPYTPDAIVKH ----------------------MHEVVSLSCSHASGHLLTHLYNVQETHIPYAKNAKLSH ----------------------MGEVVNLSLSQRANHVLTHLYNNQESHIPYKKNQPVNF -----------------------MNIITVSLSSPANHVTAQLFNAQESHLPYTKSAPRFH ----------------------MHEIITISVSHRANHLATQFFNCQEASLYDNKND---S ----------------------MREIITLSFGQTAGHINADYFNSQEHYFPLA--TKSTS DPKIFLNPTIDRISKTVSYSPRALLWDAKTGNGSLGSYQYSDG---SD---YYFKNDDDK ENDVFLNPNIDKVSKTVSYTPRALLWDAKLGNGSLGTYQYVSENDYAD---TLDSEQGAT DSKIYLNPVVDRFSKTVSYTPRALLWDARTGNGSLGTYQYAET---KD----YHFGNEDE EPSIFLNPTIDRISKTVAYSPRAILWDARTGNGSLATYQYAPD---TH---DYHYQDTDA DSKIFLNSVVDKVSKTISYAPRALLWDARTGNGSLGTYQYSES---QD----YHFGNEDK ESSIFLNPTIDKSSKTVSYTPRALLWDARTGNGSLGTYQYSET---RD----YHFGNEGE DSKIFLNPTIDKVSKTISFAPRALLWDARTGNGSLGTYQYSDT---QD----YHFGNEDK DSKIFLNPTVDKVSRTVSFTPRALLWDARTGNGSLGTYQYSET---QD----YHFGNEDR ------------------------------------------------------------ DPSVFLHGTIDADGRTMSYEPRAVLWDAKGGSGALGRFQYWSQ---DD--YADEEEPPRA DPSIFLDPVVDLVSKTISYTPRALLWDAKTGNGALGTYAYSET---KD-------SYDEN DLQVFLTRFKST---SVSYSPRALIYDLRNGLGALNKYEYHETLPVDLNAPAGAETGAGS EPAVFLAPNVDRISKTVSYKPRALLWDSRTGNGSLGMHQYDSA---DD--FYFAPDREAQ DNSVFLSTSKNPNG-TVNYSPRSLNYDLTRGYGSLGKYEYYES-------------KADI DLQVFLTRYKST---SVSYSPRALIYDLRNGLGALNKYEYHEPLPVDFNTASASASATNN DLNTFLYKSLSLSSGSSSYFPRALVFDLRGGLGALGKYEYSEQVPSSLDASSASSASSSS DLQVFLSRFKSSTSTSTSYSPRALIYDLRNGLGSLNKYEYHESIP-QL------------ SNSVFLWPVKAGAR--CNYYPRSLNIELAGGYGYLGKYEFKDP-----------KVDLAA FNNVFLSTSKTHTG-HTNYAPRALVFDLRYGLGSLNKHEYHET-----------PTNFDN DYSAFLSTTKNKNG-TTNYAPRALVYDLNGGFGGAPKYEVDPS----------------T EKSIFLNPIVDRLSKTVSYYPRALLWDAKTGTGSLGKHQYFNE---DD---YYNFDDGDN DPTVRFRRGVATDSRTETYNPRLLTWELKGGYGAFQAFNQFYT--------EGDKSQPQV PS-DGDLMQTHPVIPKSDYQRAL-----DAGLP-EPKLNNSNTKYWSDYARLIYQPSSFN AK-TAHRVQTHDRIRKSPYQLAL-----DQGATVLPKINDEIAKYWSDYSKLIYDPSSFN FK-DQTVVKTHPTIPKSEYQIAL-----DTAIP-LPTLTKENTKYWSDYSKLIYGASSFN PTPSTNIMTTHPRIPQSEYQKAL-----DKNEP-LPRLNKENTKYWSDYSKLIYSPKSFR FK-EQTVIKTHPRIPKSEYQSSL-----DAGAP-LPCLNRENTMYWSDYSKLIYGPSSFN FK-DETVIKTHPKIPKSEYQDAL-----DAGIP-PPALSKDNTKYWSDYSKLIYGPSSFN LE-AQTVIKTHPVIPKSDYQSAL-----DAGVP-LPSLNKKNTNYWSDYSKLIYSPSSFN FK-DQTIIKTHPKIPKSEYQSAL-----DAGTP-LPTLSRENTKYWSDYSKLIYGPSSFN ------------------------------------------------------------ AP-GIEVVQTAARVRRSAYQRAL-----DAGEA-PPALTAAGARYWSDYGRMIYGQDSVQ WKESYEIVQTHHRIPKSTYQEAL-----DKGIP-TPKLNSQNTKYWSDYSKLIYPSSSFN SL-ESGYNLKKSRVEKNEYQQKL-----DQGVTDGSSLNVNNTKYWTDYNKLIYNPKSLT PPSGLQFMQTHDPIPKSEYQSAL-----DANLP-LPPLDDSNTTYWSDYSKLIFGSSNLN LG-QYEVIQTGEKMDKNEYQKAL-----DKGMNKSNTLNVNNTKYWTDYNKLIYSPKSLN SL-ESGYNLKKARVEKNEYQQKL-----DQGITDGSLLNVNNTKYWTDYNKLIYNPKSLT SF-PSSLSSPAPRVEKNEYQRNL-----DLGKPTSGLLNTRNTRYWSDYNKLIYNPKSII ---NLPILNDRRPPSKNEYQLKL-----DQGVTDGSLLNTQNTTYWTDYNKLIYNPKSLN FG-SEVEVRKQDRVEKNDFQRLL-----DAGAR--PDLNTANTSYWTDYNKLVYRPASLL IP-QSDRFNLDKQIAKNQYQQNL-----DKGIASTEALSVENTKFWTDYNKLIYSPSSLN IS-NVEVINTAPRVPKHAFQSNL-----DSGIDNAQLLSVSNTKYWTDYNKLIYKPSSCV NNVSSDIMITHPRINRSEYQMAL-----DSGSK-LPVLTPSITRYWSDYSKLIYQPKSLN WNEGEIKEIKEQPVDKNEYQKAL-----DLGRENASQLNTDTTKRWTDYNRLFHHPKTRH ILRDWYHDTDNPNRPDFKSLKDRRFDKFIIGEEEFKSNYLV-DFFDTNLHHELEQCDTLQ TLQDWYHDAANQQKPNFQNLRQVYFDNYETGSNQFRENYSN-EFFDSNLHQQLEKCDSLQ TLKDWYHDVANPNQPDFQNLGERKFNKYSIGYDEFTENYMQ-EFFDGNLHTELEKCDTLQ GLKNWYHDIKNPNLPDFHNLQQRQFTDFAMGFDEFKSFCMD-DFIDEQLRIQLENCDTIQ ILRNWYHDTENPNQPDFQNLGERKFDRYSIGYDEFTENYLQ-EFFDGNLHRELEKCDTLQ ILKDWYHDVANPNQPDFQNLGERRFDRYSIGYDEFTENYLQ-NFFDGNLHTELEKCDTLQ TLKDWYHDVANPNQPDFQNLGERRFDRYSTGYDEFTENYLQ-DFFDGNLHTELEKCDTLQ ILRDWYHDVENPNQPDFQNLGERKFDRYSIGYDEFTENYLQ-EFFDGNLHTELEKCDTLQ ------------------------------------------------------------ ELAHWHHDVAAPSAPDFEALGQRRFDRYENGYEVFTEECAR-DFFDISLHRQLEQCDTLQ ILHNWYHDVNNPSLPDFQNLGQMKFDKFDIGVQEFRGTHCD-GFFDGNFHTQLEQCDALQ TVNNFVHNENNHESGYHYNFNSLKYDSFNIGQEEFKACNDN-NKSIENFRYFLEKTDRLQ TLRDWYHNTAHPSAPDFQNLHQTYFDQYDVGYKEFSSKYRS-DFFDEKLRAQLESCDGLQ QLNNWEYKPHDF--GINRSFPNLKFDTFNKGKEEYHQYS---EDSLENFRNTLEQCDLIQ TVNNFVHNENNHESGYHYNFDNLKYDLFNIGQEEFKACNDS-NKLIENFRYFLEKTDKLQ TLPNYQHVHNQP--GSHYNFNNQKFATYDVGHAEFNNALLE-DEIMESFRSWLERCDYLQ TLTNFIQSPNSK--GHHYNFDKLKFDFFNIGQEEFKENNNEDDKLIEDFRYFLEKTDVLQ QSENYVHPM-----GNHKHFQKLLFKEYNVGEEEFALLF---DAVDDSFRKNLEASDMIQ TLQNYDIGQSPEY-GSHHNFPQIKFNTFEVGQKEFSDSTSNLDSQLDSFRRLLEQCDLLQ SLQDWDSGTPY---GTNRNFPRLKFDTYSVGWEEYKKCQ---ETSIDEFRKYLEECDLLQ TLRNWYHDVEEPNLPDYENLGERKFNDYIIGYDEFNDNYSM-DFFDDNFHYQLEQCDSLQ QLDNWLFDPD-----------TAPQGIHRGGDQKWTGFDSDKEYLDSTLRSWVEECDSLG GFNIITDIDNGWGGFSSALLVELRNEL------PKNTYFSWAFHESDPYTVSYTRNQFNK GFNIITELDNGWGGFSSSMLLELKDEL------PKVSYHTYGWNQDDVCSLKEP--VHST GLNLITDVESGWGGFSSALLLELKNEL------PKKTVFSWGFNEDDPFTDVLSVKRLTK GFNLVTDLDSGWGGFSSKLLEELRDEL------PKVDVFTWGFNDNDYYSGA-------- GFNLVSDMESGWGGFSSALLVELRNEL------PKKAVFSWGHNEDDPFTDDFPMKRLSK GLNLVTDVESGWGGFSSALLLELKNEL------PKKTVFSWGFM---------------- GLNIVTDVESGWGGVSSALLLELRNEL------PKKTFFSWGHNEDDPFTGDFPLKRLNK GLNLVSDVESGWGGFSSALLLELRNEL------PKKTVFSWGFNEDDPFTNDSPMKGLSK ------------------------------------------------------------ GFNLVTETDNGWGGFMAALQEQLREEV------PKVCYFGWGLNVDESGP------RHPP GFNLVTELDNAWGGFTSELLVELRDEL------PKINVFTWGFNADDVLSRKQL--IHST GLQLLTNLNDAWGGFTSEMLIDLIDEFFNNTSSDKQNLWIYGIMNSTK--------LSEK GINLLTELENGWGGFSSCLLEDLRDDL------PKTDILTWGFQHDDVLTLNQP--VHST GVNLISELDSAWGGFTNELLVDLKDEFFNNGINSKYNIWVHGLI------------NHNL GLQLLTNLNDAWGGFTNEMLIDLIDEFFNNTSSDKLNLWIYGLMNSTS--------SSDK GIQLGTSMSDAWGGFTTAMVESIQDEYFNN----KMNIWTFALLSQ----------NSNK GLQLFTNIDDAWGGFTSDMVLHLIDEYFNN--NNKMNLWIYGILDH------------TQ GINFVSEVDNAWGGFTNEMMVQLKDEYFNNGANSKHNLWCYGLLAQKP------------ GVNVVSELDSAWGGFTTLLLTEFIDEYFNGGINTKNSIWIYGLHSQ----------GPSG GVSMFSEYNSGWGGFSSHLLLDLKDEFFNNGANNKHNIWVYGLA------------KDHG GFQMITDLDSAWGGFSTALLLELRNEL------PKSVVYTWGLNEDDPLTGTVTKDMITR GLNVVVD-DSAWAGVAAKILANYRDDF-----DAKGTVVTWSVE------------AKPE K-TAEQISNKIRATTSLSQESDLFIPVYSDP--------------E-YSNWEIGSLVCPL KTKFQMLCNKIRATIALSQESDLFFPLYANT---------------KEAFWRSTGETVLL K-WLPIISNKLRTTMSIMQDSDLYFPLYAPT--------------G-LTNWETAGKTCKI ---KGDVKNKIRSTVYLGRESNLFFPLWSEN--------------NALSNWEIGGKCCKI K-WLPIISNKLRSTINMMQESDLYFPLYAAP--------------G-LTNWETAGKSCRI ------------------------------------------------------------ K-WVQIISNKLRSTINIMQESDLYFPLYAPS--------------G-LTNWEIAGKNCRI K-WLPIISNKLRSTINMMLESDLYFPLYASP--------------G-LTNWETAGENCRI ------------------------------------------------------------ RAGFQRQSNKLRATLAMLEQSDLYFPIRSEA---------------ADSLWEAGGWACHV KTKFQMLCNKIRSTLALSQESDLFFPLYARD---------------DVSLWESTSEVCLL TQSIRTKLSFIKTLIELTKQSSLIFPMNLNNESWHNNYSMLTDKYNSGSNWHQSSLYATF KTKFKMICNKIRSSLNLIRESSLFLPIFSDP---------------QLSAWRFAGRTCLL NPKLNQLYSRINSIIELSFNSTLFFPMNLNS-----------------SSECLGIKMSVI TQSIRSKLSFIKTFIELTKQLSLVFPMNLNGVGLNNNYSILTDKFNLSSNWHQSSLYATF KISTIQKISEIKSFVELSKLLNLFFPIKPDY------ASTMLQNVEMESVWHTSSIQAMF GNTIKNKVSRIKTLVELTKQSSLMFPMDLNNLKQ---NSLLTEKFDEISWWHKSSIPAMF -----NMLTRIKSIVEFSKNSSLFMPLSLPH----QQTSLLSPEFDISSSWHRAAVYASF RSSINEAISRIKTTIELSKNSTLFFPINTAP-------------------FSKGIFSSDT RMDINQKCSSIASFVELAHHSSLFFPIRPTC-----ESQILAPGFDSTSEWHQSSLTSLL A-NLHKLSNKLRASINLKQESDLFIPLYEPP--------------N-TSNWELSGMLCKI KKTRETQKNAIQTTVALSQVSSIYIPVSFPT------KTPIDADFDPTSPWHQAALFGLV FDGLNSVLDG-TDTE----K-RRNMQYLSELLQNGDNNR--KIISSANMIRKDR------ FDSVNSVFHG-SRKQAATNSNMRKMSHLTNALTLGESKR--NIVSKLNVDEYNS------ LDSVNATISQ-NNPE----Q-RKTMDYITTAVTLGDSSR--NMVTEMTIGNND------- FDTINSLFSQ-KSPE----Q-IKKMSFLEDCLMLDDKAR--KFVTNMIETDNS------- FDSINATISQ-SNLE----Q-RKTMDYLTTAITLGYSSR--NMVTGMVIGDTD------- ------------------------------------------------------------ LDSINATISQ-SDLE----Q-RKTMDYLTTAITLGDSSR--NMVTEMVIGNND------- LDSINATVSQ-SNLE----Q-RKTMDYLTTAVTLGYSSR--NMITGMVIGNTD------- ------------------------------------------------------------ LDSVNSAMCLEKSRT------LRFMNQLADRLHSGDEQR--NVVSLMSSGQRS------- FESVNAVVSR-DQRR----KSRRTFNYLTNALTLGEKHR--NIVSLMEVDSKK------- INSI---WGL-NNQL----KNQISMTHLQNDIVKLNPNQ--KIINQIKIKQEKSKQNQLF FDAVNSAVSNRSPES------RSSFSHIVGALTLGESQR--NVVSNLTAQDLD------- EDELLRGFDK-RNIVNEIKIHKNKQASNDFGMVDIDRANLYNLVDNIKIKDKPD------ INSI---WGL-NNQL----KNQINMTHLQNDIVKLNPNQ--KIINQIKFKQKENEQQQLF ---INSIWGI-NNQF----VNQVNMLRLQDSLLRGDETR--KIVNEIKIVSEAD-----N INSI---WGL-NNQQ----EGQINMSHLQSNISKYNDNR--KIINEIKIVGENE------ VNSI---WGLNCQLE-----SPVRMAEIEANLLRGFDRR--NIVNEIRIEETEK------ IEDNILRGEHERKIVNDIKLKSIDSSKVTDINSLGSIISNVDISAYYNMSAPKP------ VNSL---WEL-QSRK----QSPSHMAEFEDNLTRGSNR---NIVGEMCLKAKVS------ FDTVNSLFSQ-SNMD----Q-RRSMDYLAECIKDGDEVR--NIVSNITSTDCT------- YEPVQLMATQRTGGL--------SLDAMAALLDTTGER---NIVSEVGGTLTDV------ --------------------------------IIDYLYY----SRFPTQSRKSSSAVSEF -----------------------------------FSFY----DRM--PLYKNS--KKPS -----------------------------------YSFC----SRI--VPFKNSRTNNDY ---------------------------------NDYSFY----SRV--TPFGKNAKLNRC -----------------------------------YSFC----SRV--LPFKNSHKPNST ------------------------------------------------------------ -----------------------------------YSFC----SRI--IPFKNSHTHNNA -----------------------------------YSFC----SQI--APFKNSHKHNGA ------------------------------------------------------------ -----------------------------------YSYF------A--DAPRHRSSRGDP -----------------------------------YSFY----GKM---PSYRNDSTPSP GSDLNQFNLKDIVNLKDLSNLGKSSDTSATQREINLGIS---------KNASTNTGNDAY -----------------------------------FSFY---------SRVPRYKTTLGS --------------------------------SIDLSLS----------------DSKNS GSDVNQFNLKDIVNLQDLNSFGKSSKASDAQRELNLGIS---------KNATIDTGSDTY ASNTSQMMDVNLSNIQDWT-------------AKLLNLKSMQ-QKD--EKIDLGLTGDCE -------SNNSDMIMQDID-------------ITKFDFSNKT-KSE--EINLGVSKSTNP -------------------QESPDQFGQKQESPDHFGLV--ADANIMDMYLGQAQNANEK --------------------------------QDSSSGY----IDL--SVPTTVPTKTSS ----------------------------QKSQSKDFGVLDVPQDQI--WDLMNSVSLAKE --------------------------------DLQYSFY----PRV--KPLKTRRNDDSL ---------------------------DGDKSTVQYDSR-----LFQELFLPSRIPPKTP HVFSKCNISRSNKEMKDNAEI---KNVTNKQINTYGYKF----------ADTVSDQFKE- HTFTQCEIDRVN-------------HKESSMFHFTTYPWTN--------SDTIPDTH--- QVFSNSVINREDQMPREDPK----SATRSKRSEMFTHRYFP--------SDTIPTEFSE- HEFSICQLSRSSNPSTSGKEK---SHLKNKQ-ELYTYPYYP--------SDTIPDVYKE- HIFSKSFIDRGNQTHKHHSE----PDSRSKMIEMYTHRYFP--------SDTIPTEFSN- ------------------------------------------------------------ HVFSRSIVARGNEKCRNHPN----FDCRSKVVEMYTHKYFP--------SDTIPTEFSD- HVFSRSFIDRRSQMCQNHSE----PDPQSKIIEMRTHRYFP--------SDTIPAEFSR- ------------------------------------------------------------ HTFSRCRLLRGSHSPPETTLS------VENLELIRTYAWRP--------ADTIPETA--- CICSRC------------------------------------------------------ HNFVQNRISSSTSQNEKMMKD--KEQEQNGIINNYLNPYID----NIFQVETFPVDILKS KVFTHLSISRDPELLDPDNNC------------IKTYPWQP--------SDTIPNDYSS- KYFAKSYIIPNDQSL---------AESLNKKENFPINIYKNNRINDILNNDTFPNILE-- HNFVQNSISASTAEDVGILRD---EQGQNGIVNNYINSYID----NIFQVETFPVDILKS RYFSRNIITKQEVDIKQEDVD---------ITNMYQNLYIE---NILTGGDTFPIEILKN RNFVKNYIRSNKLEIDEEEEE--------EDTYEYVNPYIN----IILDVDTFPVDILSS QKYINLGISGEAKAIGKKATV-AKLQDPESESNHYVNPYID----EIVDVDTTPPIF--- KVINEYFVKNYVIPTEQGKLE---EKFAFKDKGIPSNVYRSRDITSIIKVDTFPYKIFNL PAYLDMGLSNSSHEFSRAIVQ--EKPGETSQKNAYTASFSA-----ITKGSTFPPTVN-- HIFSKASITRTMEI----------NHKSNDLKELFTYPYSP--------SDTIPIAFRK- HVFSDLSIARLEDQDDDANSY------------RLNQPMPE--------VSSQPEFTKQ- ----------------DSNYKLCLTSDERCRNVFKEYGDFVS--KYIKYDD-----DRED ----------------HSCAESVIGVTEKPRDVLKTWEDLVS--RYFRYDS-----DREE ----------------DCEFSLKLTSSEKSRDIFKHWNEFVT--RHFKNDN-----DREE ----------------EVEFMINLKLTEHCRDVFNHWSDYVS--RRFRFDE-----DREE ----------------DREFVLELESSEKNRDIFKHWNEFVV--RYFKNDS-----DREE --------------------------------------------RKIRLX---------- ----------------DREFSLELNSSEKCRDIFKHWYEFVV--RYFKNDN-----DREE ----------------DYEFALELKSSEKSRDIFKHWNEFVV--RYFKNDN-----DREE ------------------------------------------------------------ ----------------RNLHHIDLGVTEKCRDVFKNWYEMVA--KQFRYDP-----DREE ------------------------------------------------------------ SSN-------------AINISTEFNVNDGLKSYLKPYIKLVSNIRNQHREYLDIIEDKEE ----------------ITNYTARLEVTEKPRDVFKSWSDLVS--RHFRYDT-----DREE ----------------DKSVYSEFSSSNTLKNDLKFYREVIK--RSRENEVIE---DKFE SSSN------------TINVITEFNVNDGLKHYLKPYIKLVANVRNQHREYLDIIEDKEE GA--------------NTKFHVEFNVHQGLRSFLKPYRVIIE--NIRNSSSSNNGGDKDE GK--------------KTKFYAEFNMHEGLKTYLKPYEKLIYNIRNQFEDIVE---DKNE ----------------SKSFSTTFGQNVSLKDTLKEYRKVIQ--RVRLPQHLQVIGDKAE QK--------------QFNFYSEFNVSTDYRIELKAYKDLIKNVRLNSQQLMGIIEDKAE ----------------GSSFVSEFAITSGIAATLKENRKFLL--RIKHNENLT---DRDE ----------------VSEFTVDLESTEVCRDVYQQWHDIVS--KYFRHDS-----DREE ----------------FVSSKTRLAVTTKPRRTLLDMAKFVS--VYERGD------EREE MKNSLENTASAYEFGWYDDSDSGDDNY--------------------------------M IKDHLGTLSLEYEHGWYDDDDSDLDL---------------------------------M LKNQLSDYASAYESGWYDDEDSGDDDM--------------------------------M LKDELSTMAAAYEIGWYDDEDSGDDQ---------------------------------M LKNELSDYASAYESGWYEDEDSGDDDM--------------------------------M -----------------------------------------------------------M LKNQLCDYASAYESGWYEDDDSCDDDM--------------------------------M LKNQLSDYASAYESGWYEDEDSGDDDM--------------------------------M ------------------------------------------------------------ LKERLGTLGAAYECGWYSDDDSGDDT---------------------------------M ---------------YFX-----------------------------------------M LLEDLNNISQEYSYGYESDDEDYE-----------------------------------M LKDELGTLASAYEEGWYDDDDSGDDL--------------MTFGTSLNNDNLRALPASLR LIEKISELIEEYTIGYDESDEEYDSN---------------------------------- LLEDLNNISQEYSYGYESDDEYYE-----------------------------------M LLEDLTNTLTAYSSGYESDDDDFYD----------------------------------M LLEDLSNIIQEYSYGYESDEDYE------------------------------------M LVEDLSQLIDEYTLDYEDESDYE------------------------------------M LIEDISHILEHYTISNEPSDEELDDDY--------------------------------- LIEDISAMIEDYKHGYDDSDEEFDI----------------------------------M LKDELATVSSNYEFGWYDDEDSGDDDY--------------------------------- MKQELGDMASKYEHGWEEESDDDDDY---------------------------------- ADEELKRKRDDSP-------------------------------------DVADSKKVKV PETLNDSNKRALPEVNSELESTETPVKKV---------------------KLNDKDEAKP SEPKIDSAVDEKP------KVEQAAVK-----------------------ETVDGLDKTS NGTV----------------------------------------------NDVEGKKSNN SETNGGNAARENS-------------------------------------EVKQTAVENP SDSKIGNAANKKH-------------------------------------EVEQAAAENP SETNNSNATKEKS------EVEQAAVE-----------------------CPIGELDKSA SETNGGNVANENS-------------------------------------EVKQTAVESP ------------------------------------------------------------ PEQPIVEKADSNG------HAEPEAAKRT---------------------RSEGSGEAEE PKTEKNDTIKKKN------E------------------------------ETVVNLESKS PDESPSKRKIDSD------ESTSVQLKRT---------------------KSIAHDDLRQ YSKPAKMKVAAKE------TSSGDKPSVT---------------------KSQSDGETVS MSNDTSNKRKLEE------EDLSDNKKVR---------------------QESPDSVVDD PDESPSKRKIDSE------ELSSVQLKRT---------------------KSIAHDDLRQ AKFSPNNSDSTTS-------------------------------------STTGSTLTSK SNESPAKRKIEAE------EVTSVQLK-----------------------RTKSTTQEDL PENPTLKRGLDA-------TEEPEP-------------------------KKSKGVSLDT -------------------TSTTKPLVTS------------------------------- WCLGVSGVWLEPN------SFISAPATTA---------------------YSMGDTVHKR ---MSENVGKVEK-------------------------------------ETVADTEASL ----MSKRTREER------ESIATPQKIDIK-------------------RRKSEEDVVD NETVKDNSS--------------------------------------------------- SEETDKFIT--------------------------------------------------- KRPREEAQD--------------------------------------------------- STPIKETID--------------------------------------------------- IDKLDGTPK--------------------------------------------------- IGGLDKTPK--------------------------------------------------- KRPRENNQD--------------------------------------------------- IDKLDRTPK--------------------------------------------------- ------------------------------------------------------------ QVEPHKKLR--------------------------------------------------- PTSDGSPKR--------------------------------------------------- SIVKEITKT--------------------------------------------------- ASKRERSPE--------------------------------------------------- LNYLKESIK--------------------------------------------------- SIVKEITKK--------------------------------------------------- TTNPKSPAS--------------------------------------------------- KESIVKEIT--------------------------------------------------- KESNSVPVS--------------------------------------------------- ------------------------------------------------------------ PAPEEQPEA--------------------------------------------------- EMNENITSK--------------------------------------------------- AAEVETTPT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------KPVTGIKWTP -----------------------------------------ELDTKSNEHSTVSESEE-S -----------------------------------ENDTANEEANSVERPKNIETAET-- -------------------------------KEEEETIGKSELSNDDDEKKNKKEED--- --------------------------------------------DVNALKRSRDDKE--- --------------------------------------RPREKDQDEQAEETSDKSEA-- --------------------------------------RPREEGENKQEEEAGDRSEP-- ---------------------------------------------KQGKEISDKSETT-- --------------------------------------RPRENDQDKQREETSDKLEP-- ------------------------------------------------------------ --------------------------------------KATEEPESASETVCEDKAE--- -------------------------ARSEGDSNEKTADEQVKRAKVDKGKVEPDGKDD-- --------------------------------FEERISKLEARISKLEEEFPNEEEEK-- ------------ASEDLEESAKRLKNEESLDIDQKKEQKDESKIASKDESATTETTEK-Q ------------QEIFKTFEDRFNRLENEIIQLKSTSKDDSGTLSERTANEGSVDTPP-- ------------------------FEDRIVKLETRILKLEEEFSNEKEKEQQQLQQQQ-E ------------------------------------------------------------ ------------------------------NIFEDRISKLEARIKKLEDELLIDDEEL-- -------------------------------------ADSKEETTSDIELKTNSNADE-- ------------------------------------------------------------ ----------------------------------KKLKSETGQDASTAKSSTLESSTP-S ------------------------------------------RIRDNEEGSNLEDKHS-- SEEDVADAVAEAAEETKAIAAETQVVADEIKAAEKEVEELKEEVKADENDTKQESKEV-G K---------------QQSKDTISESSSE------------------------------- ----------------TETAVTKEEDTNN------------------------------- ----------------DEEESSHKKTKTD------------------------------- ----------------NEEEGEIEQNSND------------------------------- ----------------PNKNDEEKKEEGK------------------------------- ----------------LNGDDRDKRGEEK------------------------------- ----------------NDDNHEKRDKEAK------------------------------- ----------------SNDNDGEKKEEGK------------------------------- ------------------------------------------------------------ ----------------HGDDSGGEQQTTR------------------------------- ----------------VSKEKGASDQSDS------------------------------- ----------------SEEEKEEEKETKK------------------------------- G---------------SSQEAAKEEKVTE------------------------------- ----------------DEASLKVSSGVPK------------------------------- KE--------------TEKKNTVNIDTKQ------------------------------- ------------------------------------------------------------ ----------------KEEDKKIEKETQE------------------------------- ----------------VEENVKDQAKADE------------------------------- ------------------------------------------------------------ N---------------SNTNSGTSKPVLK------------------------------- ----------------SDDENNRKKLKTE------------------------------- K---------------EAGDAGSKQESNA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ENAASIDNQQP------------------------------------------ -------SLKSDGAEEKDVPEPSEPVGRDEVEL--------------------------- ----LHPLNPTVGELPKSNSNPFNEIKGFKSMES-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------DNNTETKADETTGTKADETIETKAGE--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------QERRILNKEPPPL-------------------------------- ------------------------------------------------------------ ------------------ETKKP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------VKDEVKEDEPKK---------------------- --------------------------KKEEEAKE-------------------------- --------------------------DTKTVDKQSSED---------------------- --------------------------TKKKLKIEPSSE---------------------- --------------------------KDQEPSHKKIKV---------------------- --------------------------KEQESSHKKAKT---------------------- --------------------------KDHELPHKKVKT---------------------- --------------------------KDQESPHKKIKV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KKDSPENNDSGPKFV------------------- --------------------------DRRILNKEPPPLPKR------------------- --------------------------AKKKGETEATKEVEK------------------- --------------------------NEKSTDPKPSKHTFG------------------- --------------------------PKRQATFGSSSFSFS------------------- ------------------------------------------------------------ --------------------------ERKVLNKEPPPLPQR------------------- --------------------------DKSKVDEE-------------------------- ------------------------------------------------------------ --------------------------RKSADETDKKTV---------------------- --------------------------SGGDLAKDTIVATNE------------------- --------------------------TAETVTESATETKLA------------------- --------------------------------DKVDESKESVSDE--------------- ------------------------------KDEGAKAEIEGKKTE--------------- ----------------------------------AGRVDDEERKD--------------- -------------------------------TKDDEEKTKTEEDK--------------- -------------------------------DDGKTVESGIVEDD--------------- -------------------------------DDENAADTGKVEDD--------------- -------------------------------NDGSAAGTAAVECD--------------- -------------------------------DEGKAVDTGSVEDD--------------- ------------------------------------------------------------ ----------------------------------NGELSAAAEAQ--------------- ------------------------------FGSASKFSTGFGISN--------------- ---------------------------------QATFGSNSFSFS--------------- -------------------------------GAEKGAEKEASKAS--------------- -------------------------------GSSFKINTPMNSFV--------------- ----------------------------------PGKITPLNSFN--------------- ------------------------------------------------------------ ---------------------------------KATFGSNSFSFS--------------- ---------------------------------TSGATQETKSEA--------------- ------------------------------------------------------------ -------------------------------SSDATPATPANSVS--------------- ------------------------------KITKDDKHSNVSTEE--------------- ----------------------------------KAAETKTESSA--------------- ---------------------------------------SKDE----------------K ---------------------------------------PKPE------------KDVEK ------------------------------------------------------------ ---------------------------------------KEQE----------------K ---------------------------------------KKED----------------- ---------------------------------------KKKD----------------- ---------------------------------------KKKD----------------- ---------------------------------------KKKD----------------- ------------------------------------------------------------ ---------------------------------------PQKQ------------AAGDA ----------------------------------------------------------KS ---------------------------------------PGKI--TPLNSFNDTNTVPNS ---------------------------------------PETP------------KSAAK -------SNAN----------------------------PADT-------PTAPNTAQSS ---------------------------------------DATT-------------VPSS ------------------------------------------------------------ ---------------------------------------PGKI--TPLNSFNDTTTVPSS ---------------------------------------PKSK----------TNDAHVE ------------------------------------------------------------ ---------------------------------------SSNN---ANETPTAPNTRLSS ---------------------------------------SDKT---------SKPAIEEK ---------------------------------------PETK----------DTNGDSK P-------KFVF---GSSSA---------------------------------------- P-------SFTF---GQSSS---------------------------------------- --------KFVF---GAASN---------------------------------------- P-------KFVF---GSTTS---------------------------------------- --------KFVF---GAASK---------------------------------------- --------KFVF---GAASK---------------------------------------- --------KFVF---GAASK---------------------------------------- --------KFVF---GAASK---------------------------------------- ------------------------------------------------------------ P-------RTAF---GERPP---------------------------------------- P-------SPAF---GSSTT---------------------------------------- P-------KPVF---GATTS---------------------------------------- P-------KFAF---GASSG---------------------------------------- P-------QHVF---GATSS---------------------------------------- P-------KPVF---GATTS---------------------------------------- --------KPAF------------------------------------------------ P-------KPVF---GATTS---------------------------------------- H-------KPVF---GSTSK---------------------------------------- ------------------------------------------------------------ P-------QHVF---GATSS---------------------------------------- P-------KFVF---GASSA---------------------------------------- P-------KHVF---GTNSK---------------------------------------- --FTG------------------------------------------------------- --FVS------------------------------------------------------- --FGT------------------------------------------------------- --FGA------------------------------------------------------- --FGT------------------------------------------------------- --FGS------------------------------------------------------- --FGT------------------------------------------------------- --FGT------------------------------------------------------- ------------------------------------------------------------ --FVA------------------------------------------------------- --FGG------------------------------------------------------- --FGNMN----------------------------------------------KLSASST --FSA------------------------------------------------------- --FGS------------------------------------------------------- --FGN------------------------------------------------------- ------------------------------------------------------------ --FGAMER----------------------------------------PSTKSSSPEQKP --FGN------------------------------------------------------- ------------------------------------------------------------ --FGN---------------------------------------NASFSKSSVVMGKSSD --FSS------------------------------------------------------- --FSG------------------------------------------------------- ------GFGVAK------GKEDKKDTEN-------------------------------- ------GFGVAT------KPFGAANAFSAGLPAA-------KTTEKDGNK---------- ------GFGVAK------GDTQNEKS---------------TNTKSSSAS---------- ------GFGVKT-----------------------------STKEKEESS---------- ------GFGVAK------KDTKDGDAT--------------TSTESLPAS---------- ------GFGVAQ------KDTKDEKTTR-------------ISTASLSAS---------- ------GFGIAK--------KDMKDGELA------------NSVKSSSAS---------- ------GFGVAK------KDTKDEEEAT-------------TSTESLPAS---------- ------------------------------------------------------------ ----AKPFGAAG---------FSVKKDGAAASGS-------ASPPGAGAP---------- ------GFGTLK------KEEKNDKKKNEEKDEQEEEC---LKAEKEKKE---------- PEPAKSTITTTS------SSSTTLSKPTT------------STPATFGS----------- ------GFGVAK------TSSPGTEASELQ-----------SDSVSNSSS---------- ----ASAFDVAK------SKKNVFEALPSKTTNEI------SKSPSAEIS---------- ------------------MNTSSASSTPEPAKS--------TTTTSATLA---------- ------GFGSGS------------------------------------------------ EFKSPSAFGTSP---------SSIKESASVSNST-------TTSATFGS----------- ----ASIFDKMK-----------------------------DRPSIFDSK---------- ------------------------------------------------------------ NNSGKHVFGATS------SFGTSIEDIKKRPNVF-------ESLPSKLND---------- ------SFGVAN------KNNSNNS----------------VTSNQNKSE---------- ------GFGAFK--------GGSLWGKPASTTTSSIT----TPASPAPAA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------QTETPKAAF------ ---------------------------------------------DTVKVEPGF------ ---------------------------------------------DATTKKPF------- ----------------------------------------------KDNSKPF------- ---------------------------------------------DSKTKKPF------- ---------------------------------------------ENTTKKPF------- ---------------------------------------------DSKTEKSF------- ---------------------------------------------NNKTKKPF------- ------------------------------------------------------------ ---------------------------------------------SAGDPKPF------- ---------------------------------------------ENPSSKPA------- ------------------------------------------------------------ ---------------------------------------------SKPASKPA------- ---------------------------------------------KSNSSSVTS------ ---------------------------------------------KPTTSTPA------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PEETKASES------ ------------------------------------------------------------ ---------------------------------------------KSDTPKLTS------ ---------------------------------------------TAEPVKPF------- ---------------------------------------------ASTGSSGY------- -----------------------------------SFGSG-------------------- -----------------------------------SFGSG-------------------- -----------------------------------AFGSG-------------------- -----------------------------------AFGSG-------------------- -----------------------------------AFGSG-------------------- -----------------------------------AFGSG-------------------- -----------------------------------AFGSG-------------------- -----------------------------------AFGSG-------------------- ------------------------------------------------------------ -----------------------------------SFGSG-------------------- -----------------------------------AFGSG-------------------- -----------------------------------AFGSN-------------------- -----------------------------------AFGSG-------------------- -----------------------------------SFGSG-------------------- -----------------------------------TFGSTF------------------- -----------------------------------TFGNK-------------------- -----------------------------------TFGSN-------------------- -----------------------------------KFGSSS------------------- -----------------------------------TFGA-N------------------- -----------------------------------SFGAN-------------------- -----------------------------------SFGSG-------------------- -----------------------------------VFGSA-------------------- ---LSFGS------------------------------------------------GF-- ---LSFGA------------------------------------------------GFKA ---LSFGS------------------------------------------------GF-- ---LSFGS------------------------------------------------GFGV ---LSFGS------------------------------------------------GF-- ---LSFGS------------------------------------------------GF-- ---LSFGS------------------------------------------------GF-- ---LSFGS------------------------------------------------GF-- ------------------------------------------------------------ ---LAFGS------------------------------------------------GF-- ---FAFGA------------------------------------------------GF-- ---TRFSN------------------------------------------------AF-- ---FAFGK------------------------------------------------GF-- --------------------------------------------------------TF-- GANTRFSN------------------------------------------------AF-- ---SRFGN------------------------------------------------AFQE ---SRFGN------------------------------------------------AF-- ---SSFGG------------------------------------------------SFGS ---SKFGN------------------------------------------------AF-- ---SKFGN------------------------------------------------AF-- ---LSFGG------------------------------------------------GF-- ---TKYSG------------------------------------------------GFS- ------------NVLKTKDIA-----------------ANKEEKDSKSKPE----DSDDK A-----------KVASKDSVA--------------------------------------- ------------NILKSKNDN--------------------------DSED----AKKVA L-----------KKPDEEEEP-------------KTEQKPEEETKTADSSD----TKDGK ------------NILKNKTEN-------------------------NSESE----KKATD ------------SILKNKTDD--------------------------NADN----EKKFI ------------KILKNKADN-------------------------NSGDE----NKAPN ------------SILKNKTEN--------------------------NSET----EKKAT ------------------------------------------------------------ ------------KVLKPDAKP--------------------GSTIFDKKDG----TTSPP ------------KTLNKDTPS--------------------AAGIFETNNG----NEKKS ------------QDSIKKKSF--------------------LDKEDDKQST----VDNNN ------------YALNKDKDS--------------TPKVFTSDAEKLKSPSPTAGISMAD ------------GGNTKFNNA--------------FQNSLKKKSFLDDKAN----KDGKT ------------QDSIKKKSF-------------------------LDKED----DKQSS S-----------LKLKSFLDA-------------DSTEATLESKNDTKSEN----APSLS ------------KDSLNKKSF-------------------------LDKDE----EEKKV SF----------GANSKFSNA--------------------FENSTKKKSF----LDMPE ------------KELLHKKSF------------------------LDDDSG----NSNAR ------------QESLNKKSF------------------------------------LED ------------NVLKKKDEV-------------------------TKEEK----DSEDK ------------SVLNNLKKD-----------DTKSDNPWAEKKKEDKTEDKKTDKDGED -LIPNSELK--------------------KEDSKVTSSNNAAPT-------PIKLQKEEV -KDKQTVES--------------------EKKESTPAQSREP---------TVKLTKQDV -DDKEEVNS--------------------ESEQRTKASEEPRDAAK-----PLKLQKQDI -EESVIELP--------------------TEKESEKKSKEATKDDEN----VIKLTKREI -VDKDKVHS--------------------GSEQLANASEDTKDKPK-----PLKLQKQEV -DDRDKVSS--------------------GPEPLEKASEEPKDTPK-----PLKLQKQEI --DEEKVGD--------------------GSETLARASEEPNDNPK-----PLKLQKQEI -DDKDKVHS--------------------GSEQLANASEEPNDKLK-----PLKLQKQEV ------------------------------------------------------------ -AEVDGCVR--------------------GVRRLRTLQTRTARKA------SICLQKQVT -DDENKEKS--------------------KKNEKGISSGTPSNDG------VVQLTKQEI -NDKDKEND--------------------NNTNNVSKPQEFK---------QVDLVPVEQ -KSSETSGS--------------------GESDG-----------------VVKLTKQDV -EETADTGN--------------------TAKEKTPTTQQYK---------QVDLTPVGE -TDNNNKDS--------------------NNNNNPSIPQEFK---------QVDLAPVEQ -GSGSVDNK--------------------PESQTSTTTKQFQ---------QVDLNPVEQ -DTTPTNNG--------------------SENNSTPKPQEYK---------QVDLVPVEQ -EKQEETNS--------------------DTSTGTPKSTQQYK--------QIDLQAQEV -ENKKDSEH--------------------TEEKKTPAVQQYK---------QVELEQITK -ASREKSEE--------------------SENDRSETPQQFK---------QVELSPVDN -DDQEESKN--------------------QEESSLNEESKTENG-------MVKLEKQDV KNDKDKDAD--------------------DKEKEKEQELEKEKEAEHYIGVSAPLAKKES -KSGEESEECLFQVNAKLFQ--LVDMKTGWKERGVGAVKVNR----DK-ETSKTRVVMRS -KSGEETEESIFQTNAKLYQ--LTDIKDGWKERGIGVLHLNK----DE-VSEKSRIVMRS -KSGEESEECIYQVNAKLYQ--LSKIEEGWKERGVGVIKVNK----SKKDEEKTRIVMRS -KSGEESEVCVFQANAKLYQ--LSDLKSGWKERGTGNIKLNE----DP-NTKKARIVMRS -KSGEESEECIYQVNAKLYQ--LSNIKEGWKERGVGIIKINK----SKDDVEKTRIVMRS -KSGEESEECIYQVNAKLYQ--LSKIEEGWKERGVGVIKINK----SKQDNEKTRIVMRS -RSGEESEECIYQVNAKLYQ--LSKIEEGWKERGVGVIKVNK----SKEDKEKTRIVMRC -KSGEESEECIYQINAKLYQ--LSNIKEGWKERGVGVIKVNK----SKDDDEKTRIVMRS ------------------------------------------------------------ -QRGEEAEDSLYQANVKLYQ--LVSISEGWKERGVGPVHVNK----DR-STGRARLVMRS -KSGEEAEESVYQANAKLYQ--LTSIKEGWKERGIGAIHVNK----HP-ESGKARVVMRS -TTGEEDEISHFNCTAKIFELNLSKISEGWKERGVGPLHLDQ----SKADKRQIRLVMRS -KSGEESEESVLQVNAKLYQ--LINLKEGWKERGVGALHVNK----NP-HTGKARIVMRS IRTGEENEKSHFTSTAKIFELNLTKISDGWKERGLGRLHLNQ----SLDDPQKVRLVMRS -TTGEEDEISHFNCTAKIFELNLSKINEGWKERGVGPLHLDQ----SKADKRQIRLVMRS -TTGEEDEKSLFTSNAKLFELELSKISEGWRERGVGPLHLNQ----SKRDAKQVRIVMRS -TTGEEDEISHFNCTAKIFELDLSKMSEGWKERGVGPLHLNQ----SKADPKQVRLVMRS -KTGEENEKSIFSATAKLFELDLTNISGGWKERGLGPLHLNQ----SLDDPSQIRLVMRS IQTGEENEISHFSATAKLFELDLTNISDGWKERGTGPLHLNQ----SKADK-SVRLLMRS -KTGEEDERTIFTCTAKLFELDLTKISEGWKERGLGPLHLNQ----SISSPKQTRLVMRS -KSGEELEDCIYQVNTKLYQ--LTDIKSGWKERGVGIIKINK----NK-ETGKTRLVMRS METGEEGEESIYTCRAKLYYFDLTNTTEGWKERGVGQVHINKLKPEDVTETCSGRIVMRT RGILKVILNLPLVKGF---KVEKGFPGSLQSQKYVRIVALNENNEPTQ-YALRTGKEETA RGLLKVILNLPLVKGF---SIKKGFPGSLNGEKFVRILAVDENKNPVQ-YALRTGKAEIA RGILKVILNIQLVKGF---TVQKGFTGSLQSEKFIRLLALDDNGDPAQ-YAIKTGKKETT RGILKVILNLPLIKGF---SIQKGFPGSLNGEKFVRIIAIDDNKHPVQ-YALRIGKEETA RGILKVILNIQLVKGF---TVQKGFTGSLQSEKFIRLLAVDDNGDPAQ-YAIKTGKKETT RGILKVILNIQLVKGF---TVQKGFTGSLQSEKFIRLLGVDNNGDPAQ-YAIKTGKKETT RGILKVILNIQLVKGF---TVQKGFTGSLQSEKFIRLLAVDDNGDPAQ-YAIKTGKKETT RGILKVILNIQLVKGF---TVQKGFTGSLQSEKFIRLLAVDDNGDPAQ-YAIKTGKKETT ------------------------------------------------------------ RGLLKVILNLPLVKGF---SIQKGFPGSLQSEKFIRILAADSSKGPVQ-YALKTAAPPVA RGLLKVILNLPLIKGF---SVQKGFPGSIQGEKFIRILAVDENKIPVQ-YALKTGKGEIA QGLLRVVLNYKITADT---EILKGLEASLTPGKFLRLNSVNSEGTPIQ-YLLKFGSENLR RGILKVIMNVSLVKGV---AIHKGFPASLQGEKFIRIVTVDHDKTPIQ-YAVKIGKAEMA QGLLRVVLNMKVTSDT---KLIKGLEASLSPGKFVRWNSINDQGAPVQ-YLLKFPNQTIR QGLLRVVLNYKITADT---EILKGLEASLTPGKFLRLNSVNSEGTPIQ-YLLKFGSESLR QGLLRVILNYRIVKNT---EVMRGLEASLAPGKYLRLNSLNSEGKPIQ-YLVKFANEKLR QGLLRVVLNYKINADT---EILKGLEASLTPEKFLRLNSINAEGTPIQ-NLLKFGSGTLR QGLLRVILNYKITPST---TFIKGLEASLAPGKYTRINYVSSEGKLIQ-YLIKFANQNLR QGLLKVVLNYKVNSKT---ELLKGLEASLTPGKFVRLNSVRADGTPVQ-YLLKFGSEALR QGLLRVILNMKISENT---KLLKGLEASMSPGKFLRVNSVNAEGKPVQ-HLLKFGSEELR RGLLKVILNLPLLKEF---TLYSGFPGSLQSEKFVRILAMDDNKKPVQ-YAFKTGKEETA DAVHRVVLNMGLVKGL---EVQAGMGASLSSDKVVRISTIE-DNKPVQ-YALKTGNPDAA DDLYENIKGNIPN----------------------------------MNYTPMDQMQQHQ DELYEKVNAHILEN---------------------------------MNYTPLD---QNH DELYNTIVKSVPK----------------------------------MDFAPVD--QHQH SELYDKIINLIPK----------------------------------MNFQPLE--HQHQ DELYNIIVKSVPK----------------------------------MEFTPID----PH DELYNTIVKSVPK----------------------------------MEFAPID----QH DELYNIIVKSVPK----------------------------------MEFAPMD----PH DELYNIIVKSVPK----------------------------------MEFTPID----QH ------------------------------------------------------------ EQLYKTIADLIPDKPSV------------------------------MNYTPLD---PNH DELYDNITKLIP-----------------------------------MNYTPLD--QNHM NELVDKIDALKEQIKN------------------------------MSNYTQMD-PANQP NELYDTITKLIP-----------------------------------MNYTPLD--QSAF DELIEKVENLKETFETESMSKGTESSSGVESKETKPNATGVKWL--MSNYTQLD--HTHD NELVDKIDALKEQIKE------------------------------MSNYTQMD-PTNQG DELVSKIDELKTEM--------------------------------MSHYTQLD-PSHGD DELVEKIESLKQSIKE------------------------------MSNYTQMT-PANQD DELLEQVDALKKTMKETKEGEGKTVTEEKEATTKK------------MSYVPIQ----NE NDLVEKVDALKKEIDT------------------------------MSNYSQME--QSQI NGLYDDVEKLKGEKEKDKGDKDKEKKDATK--------------SLFQLIASLIYTHLQN LELYDNIKTEIPE----------------------------------MSYTPMDQLEHQH KQLLAGIKGLIPV---------------------------------------------MS HNQQVATVLCCNCGTPIDG-SSGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPP MQHQHATVLCCSCGVPMDG-SSGLVMCYDCIKLNVDITEGIPREANVSFCRNCERFLQPP QHQNAATLLCCNCGTPIDG-STGLVMCFDCIKLTVDITQGIPREANISFCRNCERFLQPP HQQQVSTVLCCNCGTPIDG-STGLVMCYDCIKMTVDITEGIPREANISFCRNCERFLQPP QHQNAATLLCCNCGTPIDG-STGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPP QHQNAATLLCCNCGTPIDG-STGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPP QHQNAATLLCCNCGTPIDG-STGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPP QHQNAATLLCCNCGTPIDG-STGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPP ------------------------------------------------------------ MQQQAATVLCCNCGVPMDG-SSGLVMCYDCIKMTVDITEGIPREANVSFCRNCERFLQPP HNHQTATLLCCNCGVPMDG-SSGLVMCYDCIKLTVDITEGIPREANISFCRNCERFLQPP GGAQVATVLCCNCGVPMDG-SSGLVMCYDCIKLNVDITEGIPREANVSFCRNCERFLQPP HNHQAATVLCCNCGTPMDG-SAGLVMCYDCIKLTVDITEGIPRESNVSFCRNCERFLQPP QQQPVATVLCCNCGVPMDG-SSGLVMCYDCIKLTVDITEGIPREANVSFCRNCERFLQPP GGAQVATVLCCNCGVPMDG-SLGLVMCYDCIKLNVDITEGIPREANVSFCRNCERFLQPP QSGPVATVLCCNCGVPMDG-SQGLVMCYDCIKLNVDITEGIPREANVSFCRNCERFLQPP GGAQMATVLCCNCGVPMDG-SQGLVMCYDCIKLNVDITEGIPREANVSFCRNCERFLQPP AQGPVATVLCCNCGVPMDG-SSGLVMCYDCIKLNVDITEGIPREANISFCRNCERFLQPP GSQPIATVLCCNCGVPMDG-SQGLVMCYDCIKLTVDITEGIPREANVSFCRNCERFLQPP TPAQVATVLCCNCGVPMDG-SSGLVMCHDCIKLTVDITEGIPREANLSFCRNCERFLQPP QHQNVATVLCCNCGAPIDG-STGLVMCYDCIKMTVDITEGIPREANVSFCRNCERFLQPP VSAFKATVLCHNCGTPLDGTTNGTPICNQCIEMTTDITKEIPREASLTFCRNCDRWLQPP GQWIRAELESRELLAICLRRLKGLNKVRLVDASFIWTEPHSRRIRIKLTVQGEAMANTII SQWIRASLESRELLALCLRRLKGLNKVRLVDASFIWTEPHSRRIRVKLTVQGEAMANTII GQWIRAELESRELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRIKLTVQGEAMTNTII GQWIRADLESRELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRIKLTVQGEAMANTII GQWIRAELESRELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRIKLTVQGEAMTNTII GQWIRAELESRELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRVKLTVQGEAMTNTII GQWIRAELESRELLAICLRRLKGLTKVRLIDASFIWTEPHSRRIRIKLTVQGEAMTNTII GQWIRAELESRELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRIKLTVQGEAMTNTII ------------------------------------------------------------ GQWIRAELESRELLALCLRRLKGLNKVRLVDASFIWTEPHSRRIKVKLTVQGEAMTNTII GQWIRAELESRELLALCLRRLKGLNKVRLVDASFIWTEPHSRRIRVKLTVQGEAMSNTIV GQWIRAELESRELLALCLRRLKGLNKVRLVDASFIWTEPHSRRIRIKITVQGEAMANTIV GQWIKADLESRELLALCLRRLKGLNKVRLVDASFIWTEPHSRRIRVKLTVQGEAMANTII QHWIKAELESRELLALCLRRLKGLNKVRLIDASFIWTEPHSRRIRVKLTVQGEAMSNTIV GQWIRAELESRELLALCLRRLKGLNKVRLVDASFIWTEPHSRRIRVKITVQGEAMANTIV GQWIRAQLESRELLALCLRRLKGLNKVRLIDASFIWTEPHSRRIRVKITVQGEAMANTIV GQWIKAQLESRELLALCLRRLKGLNKVRLVDASFIWTEPHSRRIRVKLTVQGEAMANTIV QQWIRAELESRELLAICLRRLKGLSKVRLIDASFIWTEPHSRRIRVKLTVQGEAMQNTIV QQWIRAELESRELLALCLRKLKGLNKVRLVDASFIWTEPHSRRIRVKLTVQGEAMANTIV TQWIRCALESRELLALCLRKLKGLNKVRLVDASFIWTEPHSRRIRVKLTVQGEAMANTII GQWIRAELESRELLALCLRRLKGLNKVRLVDASFIWTEPHSRRIRVKLTVQGEAMVNTII SSWTAAQPESRELLALCLKRLKGLSKVRLVDASFIWTEPHSRRIRIKVTVQGEAVGQTII QQTFEVEYVVIAMQCADCARSYTTNTWRATVQIRQKVPHKRTFLYLEQLILKHNAHVDTI QQTFEVEYVVIAMQCPDCARSYTTNTWRANVQIRQKVPHKRTFLYLEQLILKHNAHVDTI QQTFEVEYIVIAMQCPDCARSYTTNTWRATVQIRQKVAHKRTFLFLEQLILKHNAHVDTI QQTFEVEYVVIAMQCPDCAKSYTTHTWRAAVQIRQKVPHKRTFLYLEQLILKHNAHVDTI QQTFEVEYIVIAMQCPDCARSYTTNTWRATVQIRQKVPHKRTFLFLEQLILKHNAHVDTI QQIFEVEYVVIAMQCPDCARSYTTNTWRATVQIRQKVPHKRTFLFLEQLILKHNAHVDTI QQTFEVEYIVIAMQCPDCARSYTTNTWRATVQIRQKVPHKRTFLFLEQLILKHNAHVDTI QQTFEVEYIVIAMQCPDCARSYTTNTWRATVQIRQKVPHKRTFLFLEQLILKHNAHVDTI ------------------------------------------------------------ QQTFEVEYVVVAMQCADCARSYTTNTWRASVQIRQKVPHKRTFLYLEQLILKHNAHVDTI QQTFEVEYVVVAMQCADCARSYTTNTWRATVQIRQKVHHKRTFLYLEQLILKHNAHVDTI QQTFEVEYVVIAMQCPDCAKSYTTNTWRATVQIRQKVPHKRTFLYLEQLILKHNAHVDTV QQTFEVEYVVVAMQCADCARSYTTNTWRATVQIRQKVPHKRTFLYLEQLILKHNAHVDTI QQTFEVEYVVVAMQCPDCAKSYTANTWRATVQIRQKVPHKRTFLYLEQLILKHNAHMDTV QQTFEVEYVVIAMQCPDCAKSYTTNTWRATVQIRQKVPHKRTFLYLEQLILKHNAHVDTV QQTFEVEYVVIAMQCPDCAKSYTTNTWRATVQIRQKVPHKRTFLYLEQLILKHNAHMDTV QQTFEVEYVVIAMQCPDCAKSYTTNTWRATVQIRQKVPHKRTFLYLEQLILKHNAHVDTV QQTFEVEYVVIAMQCPDCAKSFTANTWRATVQIRQKVAHKRTFLYLEQLILKHNAHQDTI QQTFEVEYVVIAMQCPDCAKSYTTNTWKATVQIRQKVPHKRTFLYLEQLILKHNAHVDTV QQTFEVEYVVVAMQCADCAKSYTTNTWRATVQIRQKVAHKRTFLYLEQLILKHNAHVDTV QQTFEVEYIVIAMQCADCARSYTTNTWRATVQIRQKVPHKRTFLYLEQLILKHNAHVDTI QQSFEVEYIVIATQCPDCAKSFTANTWRASVQIRQKVPHKKTFLYLEQLILRHNAHLDTI NIQEAKDGLDFFYGQKNHAVKMLDFLNSVVPIKFKKSEELISQDTHTGASTYKFSYSVEI SISEAKDGLDFFYSQKNHAAKMLDFLNAVVPIKCKKSEELISQDIHTGSSTYKFTFSVEI SISEARDGLDFFYAQKNHAVKMIDFLNAVVPIKNKKSEELISQDTHTGASTYKFSYSVEI SISEAKDGLDFFYSQKNHAVKMIDFLNSVVPMKYKKSEELISQDTHTGSATYKFSYSVEI SISEAKDGLDFFYAQKNHAVKMIDFLNAVVPIKHKKSEELISQDTHTGASTYKFSYSVEI SISEARDGLDFFYAQKNHAVKMIDFLNAVVPIKHKKSEELISQDTHTGASTYKFSYSVEI SISEARDGLDFFYAQKNHAVKMIDFLNAVVPIKHKKSEELISQDTHTGASTYKFSYSVEI SISEARDGLDFFYAQKNHAVKMIDFLNAVVPIKHKKSEELISQDTHTGASTYKFSYSVEI ------------------------------------------------------------ SISEAKDGLDFYYSQKNHAVKMLDFLNAVVPVKAKKSEELISQDTHTGASTYKFTYSVEL SISESKDGLDFFYAQKNHAVKMLDFLNAVVPIKSKKSEELISQDTHTGASTYKFSYSVEI SIQETKDGLDFFYAQKNHAAKMVDFLQAVAPIKVKKSEELVSMDIHSGSSSYKFSYSVEI NIQEAKDGLDFFYAQKNHAVKMLDFLNSVVPIKSKKSEELVSQDTHTGASTYKFSYSIEI SIKESRDGLDFFYGQKNHAVKMLDFLSAVAPIKSKKSEELVSTDIHSASSSYKFSYSVEI SIQETKDGLDFFYAQKNHAAKMVDFLQAVAPIKVKKSEELVSMDIHSGSSSYKFSYSVEI SIQETKDGLDFFYAQKNHAAKMVDFLTSVAPVKVKKSEELVSTDIHSGSSSYKFSYSVEI SIQESRDGLDFFYAQKNHAAKMVDFLQAVAPIKVKKSEELVSMDIHSGSSSYKFSYSVEI SIQETKDGLDFFYSQRNHATKMLDFLNAVAPIKSKRSEELISIDTQSGSSSYKFSFSVEI SIKEAKDGLDFFYSQKNHAAKMLDFLSAVAPVKAKKSEELISVDTQSGNSQYKFSYSVEI NIQETKDGLDFFYAQKSHAAKMVEFLTAVAPVKNKRSEELVSQDIHSGSSQYKFTFSIEL SITEAKDGLDFFYAQKNHAVKMLDFLNSVVPIKAKKSEELISQDVHSGSATYKFSYSIEI SIQESRDGLDFFYSQRNHALKMLDFLASVTPCRHKRSEELISMDTHTAKKQYKFSYSVEI VPICKDDLVVLPKKLAKSMGDISQFVLCTKVSNTLQFMDPMTLQTADLSPQVYWRTPFNA VPICRDDLVVLPKKLAKSLGNISQFVICSKVSNSLQFLDPTTLQTCDLTAPMYWREPFSA VPICKDDLVVLPKKLAKSMGNISQLVLCSKISNTVQFMDPTTLQIADLSPSVYWRTPFSS VPICRDDLVVLPKKLAKHLGNISQFVLCSKISNTVQFLDPNTLQTADLSAQVYWRSPFNA VPICKDDLVVLPKKLAKSMGNISQFVLCSKISNTVQFMDPTTLQTADLSPSVYWRAPFNA VPICKDDLVVLPKKLAKSMSDISQFVLCSKISNTVQFMDPTTLQIADLSPSVYWRTPFNA VPICKDDLVVLPKKLAKSMGNISQFVLCSKISNTVQFMDPTTLQTADLSPSVYWRSPFNA VPICKDDLVVLPKKLAKSMGNISQFVLCSKISNTVQFMDPTTLQTADLSPSVYWRAPFNA ------------------------------------------------------------ APICRDDLVVLPKKLAHNVGNITQFVLCSKVSNTLQFLDPTTLQTADVPASVYWRTPFNN VPICRDDLVVLPKKLARSLGNISQFVLCSKISNTVQFLDPTTMQTADLSPSVYWRSPFDS APICRDDLVVLPKKLAHSMGNISRLVLCNKITNAIQFMDPNTLQTADLSAPVFWRSPFPS VPLCRDDLVVLPKKLAKSLGNISQFVLCSKVSNTVQFMDPMTLQTADLSPSVYWRNPFDS APVCRDDLVVLPKKMANSLGNISRLVLCSKISNSIQFFDPALLQSADLNAPVYWRSPFPS APICRDDLVVLPKKLAHSMGNISRLVLCNKITNSIQFMDPNTLQTADLSSPVYWRFPFPS APICRDDLVVLPKKLAHSMGNISRLVLCNKVNNAMQFVDTNTLQTADLSSQVYWRAPFPS APICRDDLVVLPKKLAHSMGNISRLVLCNKVTNSIQFIDSNTLQIADLSAPVYFRSPFPS APICRDDLVVLPRKLANQLGNIPRLVICSKVSNMLQFLDPNTLQTADLQAGVYWRAPFFS VPICRDDLVVLPKKLAHSLGNISRLVICSKITNAVQFLDPLTLQTADLAASVYWRNPFAS APICRDDLVVLPKKLAHSLGNITRLVLCSKVSSMLHFIDPSTLQTADLNAPQYWRSPFPT VPICRDDLVVLPKKLAKSLSNISQFVLCTKVSNTLQFMDPTTLQTVDLSAPVYWRNSFQP APICRDDLVVLPPSIAKSNANISPLVLCTKVTNTLHFVDPNTLQTAEIPGSVYWRKQFPS LADVSQLVEFIVLDVEPTGMSKGNRVLADITVARSSDLGMNDQVYYVRTHLGAICHAGDS LAEVSQLVEFIILDVEPTGQVRNKWVLADVTVARSSDLGSNDQVYYVRTHLGGIIHPGDS LADVTQLVEFIVLDVDSTGISRGNRVLADITLARTSDLGVNDQVYYTRSHLGAICHAGDS LADVSQLTEFIVLDVESTGISKGKRVLADVTIARSADLGINDQVYYTRSHLGAILHAGDT LADVTQLVEFIVLDVDSTGISRGNRVLADITVARTSDLGVNDQVYYVRSHLGGICHAGDS LADVTQLVEFIVLDVDSTGISRGNRVLADITIARTSDLGVNDQVYYTRSHLGGICHAGDS LADVTQLVEFIVLDVDSTGISRGNRVLADITVARTSDLGVNDQVYYTKSHLGGICHAGDS LADVTQLVEFIVLDVDSTGISRGNRVLADITVARTSDLGVNDQVYYVRSHLGGICHAGDS ------------------------------------------------------------ LADVSQLIEFIVLDVEPTGDVRGRWVLADVTVARASDLGVNDQVYYVRSHLGAICHPGDS LADVSQLVEFIVLDVEPTGQTRGKKVLADITVARSSDLGSNDQVYYVRSHLGAICHPGDS LLDATQMVEFIVLDIEPTGDIRGKYVLADIEVSRASDLGSNDQTFYVRTHLGGILHPGDS LADVSQLVEFIVLDVDPTGLTKGRWVLADITVARASDLGSNDQIYYVRSHLGALCHPGDS LLNATELIEFIVLDVEPTGDIRGKYVLADITVSRASDFGSNDNSFYIRSHLGAILHPGDS LLDATQLVEFIVLDVEPTGDIRGKYVLADIEVSRASDLGSNDQTFYVRTHLGGILHPGDS LLDATQLVEFVVLDVEPTGDVKGKYVLADIEVSRASDLGNNDQTFYVRSHLGAILHPGDS LLDATQLVEFVVLDVEPTGDIRGKYVLADIEVCRASDMGSNDQSFYVRTHLGGILHPGDS LLDVTQLVEFIVLDVEPTGDVKGKHVLADITVSRASDFGVNDNTFYVRSHLGGILHPGDS LLDVTQLVEFVVLDVEPTGDVRGKNVLADIEVCRAKDMGVNDHTYYIRTHLGAILHPGDS LLDATQMVEFIVLDVEPTGDIRGKNVLADVTVSRASDLGTNDQTYYIRSHLGAILHPGDS LADVSQLVEFMVLDVEPVGISKGKHVLADITVARSTDLGVNDQTYYVRSHLGALCHSGDT LADASRLQEFIVLDIEPLGPVKGKFALADATVARVGDMGRNDTTYNIRTHLGGVLHPGDS VMGYFVGNSNYNSDLFDGLNIDH-----VPDVVLVKKLYQRKTKKSRN--WKLKRMAKEH VMGYFIANSNYNSELFDGLNIDY-----VPDIVLIKKLYQRKTKKNRK--WKLKRMAKEH VMGYFIANSNYNSDLFDGLNIDY-----VPDVVLVKKLYQRKSKKSRH--WKLKRMAKEH VMGYFIANSNYNSDLFDGLNIDY-----VPDVVLVKKLYQRKTRKNRN--WKLKRMAREH VMGYFIANSNYNSDLFDGLNIDY-----VPDVVLVKKLYQRKSKKSRH--WKLKRMAKEH VMGYFVANSNYNSDLFDGLNIDY-----VPDVVLVKKLYQRKSKKSRH--WKLKRMAKEH VMGYFIANSNYNSDLFDGLNIDY-----VPDVVLVKKLYQRKSKKSRH--WKLKRMAKEH VMGYFIANSNYNSDLFDGLNIDY-----VPDVVLVKKLYQRKSKKSRH--WKLKRMAKEH ------------------------------------------------------------ VMGYYIANSNYNSDLFDTLNFDR-----VHDVVLVKKLYQRKTRKNRN--WKLKRMAKEH VMGYFIANSNYNSELFDGLNIDY-----VPDVVIVKKLYVRKTRKNRN--WKLKRMAKEH CLGYYLTNTNINSELWDTLDTDN-----TPEVVIVKKHYARKSKKSKNRKWKLKRMAREH VMGYFIANSNYNSDLFDDLNMEH-----IPDVVLVKKQYIRKTRKNRS--WKLKRMAREH CLGYYLANSNLNSDLFDTLDTDN-----IPDVILVKKHYARKSRKSKNRKWKLKRMAKEH CLGYYLTNTNINSELWDTLDTDN-----TPEVVIVKKHYARKSKKSKNRKWKLKRMAREH CLGYYLTNTNFNSDLWDTLDTDN-----TAEVILVKKHYARKSKKSKNRKWKLKRMAKEH CLGYYLSNTNLNSDLWDTLDTDN-----TPDVVIVKKHYARKSKKSKNRKWKLKRMAREH CMGYYLTNTNFNSDLWDTLDTDN-----CPEVVLIKKHYVRKSKKSKYRNWKLKRMAREH CLGYFLTNTNFNSDLWDTLDTDN-----TPEVVLIKKHYARKNKKNKYRQWKLKRMAKEH CMGYFLTNTNLNSDLWDTLDTDN-----TPEVVLVKKHYERKSKKSKYRNWKLKRMAKEY VMGYFVANSNYNSDLFDDLNIDH-----VPDVVIVKKLYQRKSRKNRN--WKLKRMAKEH AYGYYMVTSNFNNAYWDELDKDN-----LPDVILVKKHYPGRR-KKRNRHWKLKRMALEH KDIDASQDYNNRSQR--QEMERAERDYELFLQELEEDSELRQTINLYKNQNAAV--PQEA KDIEASQDYTSRQQK--QEMERAERDYEIFLQELEEDEEMRQTINLYKSNKP----AEHE KDIDASLDYNSKAQK--QEMERAEKDYELFLQELEEDAELRQSVNLYKNQAPAA--PTEE KEIDAAQDYSSRVQK--QDMERAERDYELFLQELEEDDEMRQTINLYKNNAPAP--APQP KDIDASLDYNSRAQK--QEMERAEKDYELFLQELEEDAELRQSVNLYKNREANV--PPEE KDIDASLDYSSRAQK--QEMERAEKDYELFLQELEEDAELRQSVNLYKNRVADA--PTEE KDIDASLDYSSRAQK--QEMERAEKDYELFLQELEEDAELRQSVNLYKNRVADV--PPEE KDIDASLDYSSRAQK--QEMERAEKDYELFLQELEEDAELRQSVNLYKNRDTDV--PPEE ------------------------------------------------------------ KDIDASQDYSSRQQK--VDQERAERDYELFLQELEEDQEMRQAINLYKNSK-----PVDS KDIDASQDYSSRQQK--QEMERAEKDYELFLQELEEDNELRQTINLYKNDQPPP--ATNS NDIVANDD--SRQAR--QEQERAERDYELFLQELEEDDELRQTINLYKAGENQPQVSRNH KEIEASQDYTSRQQK--QEMERAEKDYELFLQELEEDAEMRQTVNLYKSAQE----AAKE NDIVANDD--SRQAK--QEQERAERDYELFLQQLEEDDELRQTINLYKTADDQ---YPKH NDIVANDD--SRQAR--QEQERAERDYELFLQELEEDDELRQTINLYKAGDNQPQVSRNH NDIVANDD--SRQAR--QEQERAERDYELFLQELEEDEELRQTINMYKAGDDAPVHAPAG NDIVANDD----SRQARQEQEKAERDYELFLQELEEDEELRQTINLYKAGEEAP--RKEV NEIMANED----SRQAKQEQERAERDYELFLQELEEDQELRKTINLYKAGEEA---PQDA SDIVANDD--SRQAR--QEQERAERDYEIFLQELEEDEELRQTINLYKAGAAPPP-PPSH NEMDDA------TRQARQEQEKAERDYELFLQELEEDEELRQTVNMYKAPTQ----AQFE KDIDASQDYSSKSQK--QDIERAERDYELFLQELEEDQELRQTVNLYKSSNPE---NIEE NLEDDPK-----VTK--TDLDKAEQDYEQFLQELEEDTELRGTVNLYKRTVPQMPAPKTG HEEEE-----DEDAPQIDIDELLDELDEMTLDEPEEQGEVAM------------------ GEMEE---DEDEDAPQIDIDELLDELDEMTLEDQQQGEEML------------------- HDMDE---DEDEDAPQINIDELLDELDEMTLDDGAEVAPVET------------------ HEIEE---DEDPDAPQIDIDELLDELDEMTLDDGTDDPQQQE------------------ HEMDE---DEDEDAPQINIDELLDELDEMTLEDGVENTPVES------------------ HEMDE---DEDEDAPQINIDELLDELDVMTLDDGAESAPVET------------------ HEMDE---DEDEDAPQINIDELLDELDEMTLDDGADNAPVES------------------ HEMDE---DEDEDAPQINIDELLDELDEMTLEDGVENAPVES------------------ ------------------------------------------------------------ EEMQE----TDDEAPQIDIDELLDELDEMNLDDPVEEQGEA------------------- DSMDE---DEDEDAPQIDKDELLDELDEMTLNDPSAVVHPEV------------------ DDMNDEDEDDDEDAPEIGIDELLDELDDMTLDDTPMN----------------------- NEMEE---DDDEDAPQIDIDELLDELDEMTLDEAPPS----------------------- SETDMEDEDDDEDAPQIGIDELLDELDDMTLDDHTMQS---------------------- DDMND-GEEDDEDAPEIGIDELLDELDDMTLDDTPMN----------------------- DDIDE-DDEDDEDAPTIGIDELLDELDEMTLKDTAME----------------------- DEMDD---EDDEDAPEIAIDELLDELDDMTLDDTPMNE---------------------- DDEDE--MDDDEVAPEIGIDELLDEIDGMTLD---------------------------- GDIEE-LEEEDEEAPQIGIDELLDELDDMTLEDHPME----------------------- SDMDD-----DDEAPEVGLDELLDEMDEMTIS---------------------------- HGMEE---DEDEDAPQIDIDELLDELDEMTLDDNGADEMGEG------------------ DEMEA-SEEEGEGVPEIGVDELLDDLEDMSLGQDE------------------------- ------------------------------------------------------------ ---------------------------------------------MSSSADNSNNSSSRF --------------------------------------------------------MSQF --------------------------------------------------------MSTQ --------------------------------------------------------MSQF --------------------------------------------------------MSQF --------------------------------------------------------MSQF --------------------------------------------------------MSQF ------------------------------------------------------------ ----------------------------------------------------MTMTDSSS --------------------------------------------------------MSEA -------------------------------------------MTESLFDTNFTSENESK ------------------------------------------------------------ ---------------------------------MTESLFDTKFTSEPSAGNTAGISSEES -------------------------------------------MTESLFDTNFTSENEPK -----------------------------MTESLFDTNFTSENESKPVVPTTEAAAPASA --------------------------MTESLFDTNFTSENEPKPESTTENQSIAATGSEE ------------------------------------------------------------ ---------------------------MTESLFDTKFSEPTLAKVADSASSATSASSDGQ --------------------------------------MTESLFDTKFTSESLSAGNEAA --------------------------------------------------------MSDS ---------------------------------------------------MFVRDESVA ------------------------------------------------------------ P-----AAVDSINNNS---NSINDASQFHNSY----------NEVNEINND------TNS F-----EAATPVAIPS---VNANN------------------GANDAGSSA------TGA E-----ETLPP------------------------------------------------- F-----EAATPVAIPT---NNTNG------------------GSSDAGSAA------TGG F-----EAATPVAIPT---NNANG------------------GTSDGSSAD------TGA F-----EAATPVAIPT---SNANG------------------GTSDAGSAA------TGA F-----EAATPVAIPT---NSTNG------------------GTSDAGSAA------TGG ------------------------------------------------------------ P-----APEGPAAPA------------------------------------------EAA T-----ATATTTSETT---AAA-------------------------------------A P-----EPTQQQQQQS---TQQTSQQQQQQQPSSSTLTTSIVDQ-------------SST -----------------------------------------------------------M P-----INNTGVSPST---NGSNDNANGE----------------------------TNT P-----EQQQQQQQQQ---HEHEQQQSSSSSVGATATAAETAAGTTSTSTSTIDQ--SST PAPAPASASGSDSTFV---SAPSTQQGTTAAEVPSSSADQESKKESGNTTSTAASTDANT P-----SSSTTATTPA---TGATTGAGAGNASSTTTNDGTTGATTESSSANSPIDQSTSL ------MSE------------------------------------------------DDI P-----AVSSSSSNGR---SDPQDQ--------------------------------STT P-----VVSTPQNDPP---ATPIGQDEKV----------------------------STS D-----SENKQ------------------------------------------------- D-----SNENSVANHL---NMTHDFGHVHVDHDHDHDNVDPAGNFASFAND------PIG ------------------------------------------------------------ QVN--------------------------------------------------------- APA--------------------------------------------------------- -PQ--------------------------------------------------------- APV--------------------------------------------------------- APV--------------------------------------------------------- APV--------------------------------------------------------- APV--------------------------------------------------------- ------------------------------------------------------------ APA--------------------------------------------------------- ATT--------------------------------------------------------- LPS--------------------------------------------------------- AEL--------------------------------------------------------- LPS--------------------------------------------------------- LPS--------------------------------------------------------- TST--------------------------------------STTTSGDSHQDADYDNSAA PSL--------------------------------------------------------- LPS--------------------------------------------------------- LPS--------------------------------------------------------- LPS--------------------------------------------------------- -TT--------------------------------------------------------- NPA--------------------------------------------------------- -----------MPVSHRILLSLKEAAKVIGTQGNSIQSVRDNNNVKIGISEKVPGCSDRV ---------NGNNITFHVLVSLKEAAKIIGPQGNTIETIRRENDIKIGISPREKSCSDRL -----AGAGAQPTINHRLLLSLKEAAKIIGTKGSTISRIRATNSVKIGISEKVPGCSDRI --------TVSPTIVLRVLLSLKEAAKIIGLKGSTISKIRETHGVKIGISEKVTGCSDRI -----VGTTAQPTINHRLLLSLKEAAKIIGTKGSTISRIRAANAVKIGISEKVPGCSDRI -----VGAVAQPTINHRLLLSLKEAAKIIGTKGSTITRIRAANSVKIGISEKVPGCSDRI -----VGATSQPTINHRLLLSLKEAAKIIGTKGSTISRIRASNSVKIGISEKVPGCSDRI -----VGATAQPTINHRLLLSLKEAAKIIGTKGSTISRIRAANSVKIGISEKVPGCSDRI ------------------------------------------------------------ -----KVDAQAPLVTLRLLLSLKEAARILGRGGNTIDNIRKANGVKIGISTKEKSCSDRL --------TTKPTINHRILLSLREAGSVIGQQGSTIQDIRVKNNVKIGISPKEKGCSDRI ---LQDKSNIDALINYRVLVSAKEAGCLIGTNGQVIDSIRNETNTKAGISRLIPGSHERI --------ENQDTISHRVLVSLKEAARIIGAQGMTIQKIRESSNVKIGISPHERGCSDRI ---INDNSNSSALINYRVLVSAKESGCLIGQNGAVIDSIREETNTKAGISKLQPGSHERI ---LQDKSNIDALINYRVLVSAKEAGCLIGTNGQVIDSIRNETSTKAGISRLIPGSHERI LPSLDDKSNADALINYRVLVSAKEAGCLIGQNGGVIDSIRNETNTKAGISRLTPGTHERI ----QDKSNVDALINYRVLVSAKEAGCLIGTNGQVIDSIRGETNTKAGISRLVPGSHERI ------LETQPGLINFRVLVSAKEAGCLIGQNGAVIDSIRDETATRAGISQLRPGTHERI ---LQSKVNASALINYRVLVSAKESGCLIGQNGQVIDSIRAETNTKAGISRLQPGSHERI ---VEDMSNASALINYRVLVSAKEAGCLIGQNGQVIDSIRQETNTKAGISRLQPGSHERI --------TTATSVTQRLLLSLKEAAKIIGTKGTKIQKVRDDNNVKIGISERKERCSDRI -----TLGDDTTQLVLRALVSTKEAGVIIGKDGATVAGLRDAAKVKAGVTKSVAGIPDRI LTCSGE-VEDVCSALGDVVTLL---NKP-------SENEEETDNHHFYFLNHLLP-VPTL LNVSGP-PRQVANSLGQVLRVLTTDYEP--------------EEHVFKHLRFMLP-PASK LSCAGN-IINVANAVGDIVDVL-NKRDAEKEDAAAAAEDEGEEHYYFHFLNHILP-APSK LSCAGP-IINVANALSDCVDIL-NEKDYDAEGNL--LPPLKFEKYNFHFLNHLLP-PPSR LSCAGN-VINVANAIGDIVDVL-NKRNP---ENEDAAEGEAEEHYYFHFLNHILP-APSK LSCAGN-VINVANAIGDIVDVL-NKRSS---ENEDAAEGEAEEHYYFHFLNHILP-APSK LSCAGN-VINVANAIGDIVDVL-NKRNP---ENEDAAEGEIEEHYNFHFLNHILP-APSK LSCAGN-VINVANAIGDIVDVL-NKRNP---ENEDAAEGEAEEHYYFHFLNHILP-APSK ------------------------------------------------------------ LEVTGS-IDAVANSLADVVKVL-TADDT----NEEDAEPEPEQHI-FKHLNFILP-PPSP LSCAGD-ITSVCHAIGDVMEVL-NRSRP-----------EEEEHHVYKLLNFMLP-PPSP LTVSGK-LDDCAKALSYFAQAL-INANI--------------ESYNYFPLKQLSS-TPNT LSCSGS-AQAVANAIGDVVEVL-NQDES------------EPETHSYKPLNFILP-RPSE LTVSGT-LDDCAKALSYFAQAL-CNANI-----------ENLVSYSYFPLKQLSL-NPCV LTVLGK-LDDCAKALSYFAQAL-INGNI--------------ENYNYFPLKQLSS-TPNT LTVSGK-LDDSAKALSYFAQAL-CDSAI--------------ELYNYFPLKQLSS-TPCV LTVSGK-LDDCAKALSYFAQAL-VNANI--------------ESYNYFPLKQLSS-TPNT LTVSGL-VDSAAKALSYFAQAL-VNASS-----------ETPFSYSYFPLKQMSR-IANV LTVSGT-LDDCAKALSYFAQAL-CNSTI--------------ETYNFFPLKQLSS-NPCI LTVSGT-LDDAARALSYFAQAL-CNANT-----------ETFSTYSYFPLKQLSS-TPCV LICTGS-IEDVSNAIGDICEILVTNDEDSNEKENDEYNSIEDEKFVYPFLNFRLA-KPTL LSVAGT-AAGVSRAIGLAAAAL-VAHPP-----------------SGYVLNLVPP-GPQG DDLEASEEALHEQLQNIGYLRLLVFNSQLSSIIGKGGNQIKSLIEKH--GVKLVASRAFL EEI-----EDPEKWKQIGNLRLICTNPQISSVIGQQGAKIKKLIETH--TVKLVASKHFL DEI-----RDLQQLENIGYVRLIVANSHISSIIGKAGATIKFLINKH--GVKIVASKDFL NEVV--------PVDKIGNLRLIVPNRHLSSIIGKGGVRIKALIETY--GVKIVASKHFL DEI-----RDLQQLEDIGYVRLIVANSHISSIIGKAGATIKSLINKH--GVKIVASKDFL DEI-----RDLQQLENIGYVRLIVANSHISSIIGKAGATIKSLINKH--GVKIVASKDFL GEI-----RDLQQLENIGYVRLIVANSHISSIIGKAGATIKSLINKH--GVKIVASKDFL DEI-----RDLQQLENIGYVRLIVANSHISSIIGKAGATIKSLINKH--GVKIVASKDFL ------------------------------------------------------------ DEA-EDPM----KVKQIGNLRLIVTNSQVSSIIGTAGSKIKKLIDTH--SSKLVVSKTFL QEI-----KDLESIKHIGNLRLIVTNSQVSSIIGVQGKKIKSLIDKH--GVKIVASKNFL EE--------------TTILRLLIPNSQMGTLIGSKGARIQQLQNNF--NISMIASKSFL VEI-----QDPESAKRIGNLRLIVSNSQVSSIIGTQGSRIKALIEKH--GVKVVASKNFL EGE-------------TTILRLLIPNAQMGTLIGSKGARIQQIQANY--NISMIASKSFL ND--------------TTILRLLIPNSQMGTLIGFKGIRIQQLQNNY--NISMIASKSFL EGE-------------TTIIRLLIPNSQMGTLIGSKGARIQQIQQSF--GVSMIASKLFL EE--------------TTILRLLIPNTQMGTLIGSKGARIQQIQSKY--NISMIASKSFL EGQ-------------TTVLRMMVPNSQIGTLIGARGLRIQQIQRQC--NVSMIVSKSFL EHQ-------------TTILRLLIPNSQMGTLIGSKGLRIQQIQNKY--NISMIASKSFL EGE-------------TTILRLLIPNAQMGTLIGSKGVRIQQIQANF--HISMIASKSFL DEV-----NDAETLKKIINIRVLVTRAQCSAIIGTKGDRIKSLIENR--GVRMIASNQTL ----------------TTTVRLLIPHQRMGSILGKGGVRIKAIQAKY--GVRIVASKHRL PDSTERMLEIQGVPSAIKQVLLDICEIIAKEEEERKR----FER--KYYPHLQRNNTN-- PDSKDRVLEIQGFPTSVANCINEIAELFIQDDVH-VP----PRTLPRYYPHSKH------ PDSDERIIEIQGFPGSITNVLIEISEIILNDVDVRFN----TER--SYFPHLKKSPG--- PDSSERVLEIQGFPASISKVLIEISEILLNDVDINFI----PEK--HYYPHLKHQSNGFN PASDERIIEIQGFPGSITNVLIEISEIILSDVDVRFS----TER--SYFPHLKKSSG--- PASDERIIEIQGFPGSITNVLIEISEIILSDVDVRFN----MER--SYFPHLKKSAG--- PASDERIIEIQGFPGSITNVLIEISEIILSDVDVRFS----TER--SYFPHLKKSSG--- PASDERIIEIQGFPGSITNVLIEISEIILSDVDVRFS----TER--SYFPHLKKSSG--- ------------------------------------------------------------ PDSQDRILEIQGFPNSIANCIKDISQTLIKDDVL-DT----KEK--RYYPHSKH------ PDSNDRVLEIQGFPGSITNCLVEISEILLNEIDIKVQ----PEK--RYYPHASSTPASAE PGSNERLVELQGTVDDLYDSLRIISRCLIEDFSS-IV----GTT--YYVPRGNTYNNNHS PDSQDRVVEIQGFPGSIASCIIEISELLATETKPS------HEK--QYYPHTKS------ PGSNERLVELQGTVDNLYDSLRIISRCLIEDFSS-IV----GTS--YYVPKASNYARNNN PGSNERLVELQGTVDDLYDSLRIISRCLIEDFSS-IV----GTT--YYVPRGNTYSHS-- PGSNERLVELQGTVDDLYDSLRVISRCLIEDFSS-SV----GTT-TYYVPRSHQ------ PGSNERLVELQGSVDDLYDSLRVISRCLMEDFSS-IV----GVS--YYVPRGSNSSN--- AGSSERLVELQGTVDNLYDAVRIVGRCLLSGASS-SE----ETV--LYVPRPSSKA---- PGSNERLVELQGSVNDLYDALRIISRCLIEDFSS-IV----GTN--YYIPRGHHYNNSS- PGSNERLVELQGTVNDLYDTLRVISRCLIEDFSS-IV----TTS--YYIPRGGNTTKYRG PDSDERLLEIQGTSMAITKVLEDINAVISNEV--RAT----REK--RYVPHVRRRNQPVS PHSSERIVEIQGEPLALQTAVYTVVQCLLEE-KDKSI----LVA--YYNPRSLEGSM--- ------------------SSSNNGSVGN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ HS---------------------------------------------------------- ------------------------------------------------------------ QTN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ T----------------------------------------------------------- ------------------TNTSSNTGSS-------------------------------- ---------------TLREDPEDKEYVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------TRQESDTSYHPSSNNFE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------HSHNNTNNTNINNNNNNNNN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------HNHNHNHNNNSTGVGAGSGV-------------------------- ------------------------------------------------------------ ---------------------NNSNSSSSTGGLS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------FAGYRGRHQDGGSDTDTDREATV--------------SDHGG------- --------------------------SANSQEYTATVMIPESYVGALAGKKGNRLANLRK ---------------------------TKEIQVSQTLAIPKEFVGALLGVGGNRIANLRK ----------EPS------------SPPASSSTKIELKIPELYVGAIIGRGMNRIKNLKT ------------------------NNSNNNDEFKVEVLIPEIYVGALIGKQGNRIANLKD ----------EPT------------SPSTSSNTRIELKIPELYVGAIIGRGMNRIKNLKT ----------EPL------------SPSASSNTRIELKIPELYVGAIIGRGMNRIKNLKT ----------EPT------------PASSSSNTKIELKIPELYVGAIIGRGMNRIKNLKT ----------EPA------------SPSTSSNTRIELKIPELYVGAIIGRGMNRIKNLKT ------------------------------------------------------------ ---------------------------SKDIHVTATVAIPAEYVGALLGHGGNRIANLRK ----------DPS------------STSTNVPAVQVVAIPSDFVGALLGHGGNRIANLRK ------------------------THGSGGNKTTDTISFPNDIVGALIGKRGSRIDGVRK ---------------------------QEEGSVTKEVAIPVEFVGALLGRGGNRVSSLRK ------------------------KRFNNQNAVTTSISFANDMVGALIGKNGSRIQGVRK ------------------------GGGSGAGKTIDTISFPNDIVGALIGKRGSRIDGVRK ----------------------------MTRKSTATINFPNDMVGALIGKNGSRIQGVRK ------------------------SGSGGTNTKKATLTFPNDIVGALIGKQGARINGVRK ------------------------AEVPKPATTQETVSFRDDIVGALIGKHGSRIQGVRK ------------------------SPRGANPITTASISFPNDIVGALIGKNGSRIQGVRK ------------------------DRRSSSPGISTTLYFPNEIVGALIGKNGSRIQGVRK --------------------------KSFDEEFKSIVKIPEAYVGAIVGRQGNRIANLRK ----------DAE------------ALSSSDACVQSTIIPASFAGYIIGRRGDNIRELRK FTKTKILMESRPNDDNEHEDENDMEEDDGRLRKFTIIGSSSRSVNLAESMLQRNL-ATEI FTKTKIVIGQDPTE--------------NGDRIFTVWGNDQKSVKLAQTMLLKNL-EVEK FTKTNIVVERKDDD-----------DKDENFRKFIITSKFPKNVKLAESMLLKNL-NTEI FTKTKIIIERKDDE----------SRDDSSNRIFTIIGHLPKNVKLAESMLLKNL-DSEI FTKTNIVVERKDDD-----------DKDENFRKFIITSKFPKNVKLAESMLLKNL-NTEI FTKTNIIVERKDDD-----------DKDDNFRKFIITSKFPKNVKLAESMLLKNL-NTEI FTKTNIVVERKDDD-----------DKDENFRKFIITSKFPKNVKLAESMLLKNL-NTEI FTKTNIVVERKDDD-----------DKDENFRKFIITSKFPKNVKLAESMLLKNL-NTEI ------------------------------------------------------------ YTRTKITVAQEPNQ--------------NNEREFTITGNDQKSVKLAQNMIMKNL-GTEK YTKTKIVVGTEPNS--------------QGDREFTITSDDQRNVKLAESMLLKNL-KAEM VSGAMIAISE-AIE-------------GENERVFTITGS-SHAVDKAKQMIYQNF-KREE YTKTKVIVSDEPNE--------------ENNRVFTITGNNQNSVKLAETMLLKNL-ETEK VSGATIGISD-EVE-------------GKPERVFTISGT-AHAVEKAKSLLYHNL-EREE VSGAMIAISEIIEG--------------ENERIFTITGS-SHSVEKAKQMIYQNF-KREE VSGAMIGISE-AED-------------GSDERVFTITGT-QQAVEKAKGLLYHNL-EREE ITGATISISDGGED----------------ERIFTITGS-SQAVEKAKQMIYQNY-KREE VSGATIAISE--ED-------------GTGERSFTISGS-PSAVGKAKRLLAFNL-EREE ISGATIGISE-EVE-------------GKPERIFTLSGS-AHAVEKAKELLYHNL-EREE VSGASIGISE-EVD-------------GKTEREFTISGS-SHAVEKAKDLLYHNL-EREE YSKTKIVIEKRASE-----------VSDDAERIFEIISNDIKNVELAESMLKKNL-ETEI RSGAAISISS-EYE---------------RERTLLMRGS-EAAVALAMSMLQQQM-DEER ERRKERLRNLSENNESA------------------------------------------- KRREEHEASLKDGSSVPAAAAASAATSISASGANQNDSIHTPVSDNESPVVFTE------ EKRENYKRKLESSEGHAAAAAATEHSDFMSSSEEEEEEEEGKEEEEEHDNEDEQ------ ERRQAKFNSDTIVSSGQPIKHEDIE----------------------------------- EKRENYKRKLEAAEGDATVVTERSDSASFLEEKEEPQENHDNKEEQS------------- EKRENYKRKLEASEGNITAATEHSDFTSSSEEKEEVQEEHHNKDEE-------------- EKRENYKRKLEASEGSTTAVSEHSDVPSSSEEKEEVQEEHDNEGQQ-------------- EKRENYKRKLEASEGNATAVNERSDSASSLEEKEEAQEERDNKEEQS------------- ------------------------------------------------------------ ERRLEKQ----------------------------------------------------- ERREERQAKE-------------------------------------------------- ERRKNEESRV-------------------------------------------------- QRRGENLALQSQATANEAASA--------------------------------------- QRRAESESK--------------------------------------------------- ERRRNEELSKKE------------------------------------------------ QRRAEATSAGENATEES------------------------------------------- ERRKAE------------------------------------------------------ QRRADHETHASNSFHSDEKGREDENEKGREDENEEGREHENNLAESRDGDPSRKDIADGD QRRSEAEEKN-------------------------------------------------- QRRAEAANTAE------------------------------------------------- QRRKEMEETESA------------------------------------------------ ERRAQVGSEEGNNGFCSDV----------------------------------------- ----------------------------GSVLYLWGKD-RASGISGESIALEWYLKSKAL ----------------------------SKVLHLWGLNGEPSLVSPESIALCWLLKGGYV ----------------------------NGSVHLWGENGKPSLISAESVALVWFIKACGS ----------------------------KYTVHLWGAGGAPSLISPESMALFWWLNMHND ----------------------------KGSVHLWGKDGKASLISVDSIALVWFIKLCTS ----------------------------DGSVHVWGANGKPSLISVESIALVWFIKSCDS ----------------------------NASVHLWGTNGEASLFSVESIALVWFIKLCNS ----------------------------NGSVHLWGTDGKASLISVESIALVWFIKLCAS ----------------------------SISVYLWGETGKPSLVSPESIALFWFLNSYYG ----------------------------MATIHLWGVDGAPALISPESIALFWLVNTCEV ------------------------------------------------------------ ----------------------------MLQLHVWGKDNEISIISPSCIASAYLLNQVLT ----------------------------GVTIHLWGLNGKASLVSPESVALLWLLNDIPS ----------------------------MIELHVWGHDSTISVISPECLASSWLLNLHLK ----------------------------MLQLHVWGKDYEISIISPSCIASAILLNQILT ----------------------------MIQLHVWGLQDKVSIISPQCVASVWLACLVLD ----------------------------MIQLHVWGKDNDVSVISPASIAATWLLNLTLT DGPGESEPADGTSRGEDDDQAESVSTAAMIELHIWGADKQVSIIDPESLASAWLLSIHLT ----------------------------MIQLHVWGCGTEISVISPECLAASWLLTDSLS ----------------------------DYELHVWGCDKSISVVFPECLAAAWLVTTCIP ----------------------------KRTIHLWGYDNVPSLISPESIALFWFLNTKLN ----------------------------MFRLHVWGPVSTSLTFSAPCLATIWYMQLCDI REV-EIVFANNTDISPLGRLPVLSNGDYIHGFLNIVDYLEPKRKDE------KLMELSAM ASGTQVVYSNNTDLSPTGELPILDTSAKITGLYSIIEHLVHDNDV-------KLLSSALL EQTKEVVFSNNTDLSPDGKLPVLDDGMKVTGYVNIVLYLERNRHTAKHEENKRLLEYALL EFQQEIVFSNNTDMSLNDQLPVMDASTKQKGFVDVVTYLESIIGIEVHGKGQGLLNSALL EEAKQIVFSNNTDLSSDGKLPVLDNGTKVSGYVNIVQFLHKNICTSKYEKGTRLLEYSLL EEAMQVVFSNNTDLSPDEKLPVLDNGIKVSGYVNIVQFLEKNEHTAKYEKSRRLLEYALL KESKQVVFSNNTDLSPDGKLPVLDSGIKVSGYVNIVKFLSKDTHFNNSEELERLLEYALM EEAKQVVFSNNTDLSPDGKLPVLDDGMKVSGYVNIVQFLRKNRHTSKYEKRTHLLEYSLL DYKSEVVFANNTXLSPNEELPLLENGKKWSGFVDIVSYLMVKMQNNDDVETX-LLKDGLL EC--TVVFSNNAHLSPREELPLYEDGSAAYEYPEIVEQLLGRELG--------LEERSLV ------------------------------------------------------------ PQNIEIIPSNNTNLSDINQLPVLNETKEKYGYNEIIRFIESKYLSTSTKLSLKLINKGLI GHEVTVVFSNNTDLSPNQQLPLLIEGDKKLGFTNIAGFLYE-----------SALEMALL PQNIKIVTSSNTNLSETDKLPLLSNASERYGFHNISQYISSNFDTEHSTGNDKLINSSLT PQNIEIIPSNNTNLSNINQLPILTITNKQYGYNQIVEFIEWEYLLSNDCFKNKLINKGLI SKAFEVVTSNNTNLSTSGEFPILENGQCISGYLAIALYLLSNYTSLETLQVLQLINVGLV SQGVEVVTSNNTNLSSINELPVLSE-TEKYGYNEIVSYVEENFKSEEYLGSKKLLNRTLQ PQQINIVTSCNTNLSDSGRLPLLRRTTRKYGFSEISHFISEKFPADSTKYVPQLANFSLI NTSEEIVTSSNTNVSDIGKLPVLTTAERKLGFEEISKYILETYGDTNFVSKEQLVNKALI HEKINIVTSSNTNLSKTGVLPVLKD--VSYGFGPISSFILSEFSGKNVIETKDLAQSAVI DETLEIVFSNNVGMSATGKLPILDE--LEVGFANITNYLIKLNSTDGKNGDESLLETALF DF--TVVQSSNEGLA--GELPCLETSEKKIGAESIIRYLKSLGHNLDADLTSQIKNTALL SMLDSNLKTLNEYQLYLDKNNYITFTRKELSQLLYFPFNFNAAYEYRNRAKEQCDLEYLE QFISEELKTCTMYQLYLNPVNYNEYTSKIYSYLLHWPFWYNTPLSARSRARELCDIMVTE NFIDLEMARLTDYQLFLNTKNYNEYTKKLFSKLLYFPMWYNTPLQLRFQARENCEIIGST QYTADTLRVLSHYQLYLNRKNYSDFTRKVFSTMLYWPMWYNTPLQNRSKARHECDIVDSE NYVDVEISRLTDYQLFLNTKNYNEYTKKLFSKLLYFPMWYNTPLQLRSQARENCEIIGST NFIGIEFSRLSDYQLFLNTKNYNEYTKKLFSKLLYFPMWYNTPLQLRSRARENCEIIGST NFVDIEMSRLTDYQLFLNTKNYNGYTKKLFSKLLYFPMWYNTPLKLRSQARENCEIIGSI NFVDIEMSRLTDYQLFLNTKNYNEYTKKLFSKLLYFPMWYNTPLQLRSQARENCEIIGST EF-TGELSVLTEYQMYLNKINYETFTRKAFSQSLHWPMWYNTPMNYGXGAEAEMKHLGI- CWAAERCGALSDYQLYLNRKNYEQYTRRVFSQLLPWPLWYNTPVQRRERARAQR------ ------------------------------------------------------------ NLLINKFEYINQYNLYLNNKNYENYTRKLFSSYLPFPMMYNQPSKYYAQAQEQVKILGLE HFAHDHICALTQYQLYLNKTNYDGFTRKIFAYLLEWPMWYNTPLKYRALARERCETLGYG SFIENKIHNISQYNLYINTKNYEKYTRKLFQKFFPFPMMYNQPLKFYHSAQRQVQVIGLE NLLINKFEYINQYNLYLNNKNYENYTRKLFSNYLPFPMMYNQPSKYYDQAKEQVKILGLE SQLTETLEIINQYNLFINTTNYEKYTRKLLSNFYPFPMMYNLSLSFYNTAQQKVKLLGLE NMLTSKIQYINQYNLYSNTKNYEKFTRKLFASYFPFPMMYNQPSKYHNQAQEQIKLLGLE SFLNNTTKYVNQYNLYVNTENYENYTRKLFSSYLPFPMMYNQPLKFFKSASEQVKIIGLE AKLQYKVEYIHQYNMFVNSRNYEKYTTKLFQKYLPFPMMYNQPLKLHQNAQEQVQLLGLE SLIENKLVRVHQFNLYSNLKNYEGYTRKQFKKYLPFPMMYNQPLKLYNVAQDQVRMAGLG AFLENKINILVDYQLYLDKKNYDSFTRKQFPKLMYWPMWNYTPSLKRSEVRSNFNVIGYP AYMSS-LQTITEYCLFVDEEAYQKVTRPMFNEFMPFLMQYNVSVRLREQAKDRCCAAGIK EKEDEDEDDGPAD-LAQSKTFALRGLRKRQRAEELKSVRLNRNYMHKLLEFLDQWDSITD ENESTSNHQDELSKLAQSKVFKITRDSKRQQTKKLQELKNNSRFTTKLDNVLTNWESARQ LEDDEEFIESKALSLAQSKTFKITHENKVKNKQELQQVKYNLQFDNRLQNCIKHWLEVRK GERDNEEDEDGTMLLAQSKPFKLQQRRQQMNKEQLQELKNNTRYFHKLDKFLTEWFAMRK LEDDEEFVESKAMSLAQSKTFKIAHKNKIKGKQELQQVKYNLQFDNRLQSCVSNWLAARK LEDDEDFVESKALSLAQSKTFKITHENNVKNKQDLQQVKYNLQFDNRLKTCIKHCLQVRK LEDDEEFVESKAMSLAQSKTFKIAHENKVKSKQDLQQVKYNLQFDNRLKNCVRNWLAARS LEDDQEFVESKAMSLAQSKTFKIAHKNKIKGKQDLQQVKYNLQFDNRLQDFVRNWLAVRK -------------------------------------------------------FDAR- -----GGTPAPAHALAQSKTLQATRELRERGEKALADAAAEMEYAAALDRALQPWIAVRG ------------------------------------------------------------ LINDEDDEEGDEDDVAISSLHERQLLKKSKSKQVLKESRNSMKCLILITQYIERFKTIFQ HVDDEDQPDQPD-QLVQSQAFKATQASKARNADLLKSARYNLQYLTRLGEQVTNWLEARA YFNDENDDDDAEAPVAISSLHEKQLLAKSKRKDLLKESRNSLKCLNLVNEYIDYVVLLYQ LFNDELSDE--EDEIAISSLHERQLLKKSKSKQVLKESRNSMRCLILINQYIEKFKEIFQ TVNSEQSDSEDVGEKGISGLHERYLLQKSKTKEVLKESKASMRCLMKVEKYVNEIESLKG IFNDEISDDDEEDEVAISSLHEKQLLKKSKTKQVLKESKNSMRCLILINHYINEVVKVYE TPETETFNDENEGEVAISSLHEKVMLAKSKDKAILRESRNSLRCLNILGEQISHVERLFK YINDENEEQDE---VALSALHERQLVAKSKEKLLLRESKNSLKCLHLLNDYLDYFSKLYE VFSGSSGPHDEVDEVALSALHERQMTAKSNKRELLRQSKNSLKCLNYLGEILDDIVKLNH HSDDKDYLDEKDDVMAQSKTFKIKNKLKQRKREELKAIGYNLQFNNRLVELLKMWDTVRG MASESLTNPKPSM----GKLYDQSVEREKQKDASKAVSKTVFRLLNSATEIYTDMMDTAA DLPK-TSPVPILFYSYMYIQLILPNNEICKYLKEMKNGYVDTLKETFTKYNALNLNVREP SLASAVLPADLVLVAHLKVQMALPQDLLRSHLRNQYPSLYDKVNELIEKYDNSPVPNRDP KLDESILSSDILFHANLYVQLNLPDNRIRSKLEQTFDDFMNNISSKMDEIVQGDLGQRDP NLAGDVDAIMVLFLAHLNVQLELPEDKVKDILETKFADEWEWLQPHLGAMKRLVVRVRPA KLDDSILSSDLLFLANLYVQLGLPDNRIRSKLEQTFSELLNSMSNKIDDFVHRNLEQRDP KLDESVLPPDILFYANIYVQLSLPDNRVRSKLEQTFGEFVNNTLNKIGEFVQSDLEQRDP KLDESMLSADILFLANIYVQLNLPDNRIRSLLEQTFSDFMNSTSKKIDTFIHIDLQQRAP KLDDSILFPDILFFANIYVQLSLPDKRIRSKLEQTFSDFVNNTSNKIDVFIHKNLKQRDP ------------------------------------------------------------ AAAT-LGPAELLFAAHLYVQQQLPDARVTAHLRAHYPALCDGLLRACELHACAAVAVRAP ------------------------------------------------------------ HQQRDPSSSEILFYAYIFCLTKLPDRFIFNYLKLKQ----DYTLKFITEIMNKKNKFRNP KLIKSAVPADYLLWANLFVQLELPDQLVSEHLQKCLQSTYQEITTKLKACSQAKLAQRDP ELNSFISSSELLFFAYIHSLCELPDKFIVNYLTLKYPKFLTFIYDTTSKLNESKSIFREP QQDQQPSSSEILFYGYIFCLINIPDRFIFNYLKLKH----KYILKFVEKFINNENKFRNP KEEKRPSSGDILFLACIYCLTEIPDRFIQDYLSSQKASFSETAKLKIDELQKNNCTIRPP KNGGDPSSSELLFYAYIQCLTKLPDRFIYNYLLLKQPEVLKFINETTENYSSD-VKFRDP QLNPNISSSELLLYAYFHSLTGLPDNFIANYLKQKSPAFWKFAYTITEALNTSPETFRSA KLNGNASSCEILLCAYVYSLTDLPDRFIYNYLKIKRPDFTEFIATCTQRWNTQEDAVRGP QLNPHISVAELLLFAYIHSLTGLPDHAIHDYIRLKYSSFADFSQTKINELNQLDSAIQPP NLNTEEITSDLLFWANMYILFNLPTNNIKTHITKSLESYIDMLNDKISLVSTKKVTIRDP NVAKGVSTSDVFLCAHLQLQMALPDCAVAGLLKSKFPALLQYEDVFVEKIGNKDLKVEGP VFRERGDLISTLLNKIV-MARNSNSESETKTRNSQSSRSNAKQRLTAAQQQIRDLINEHI TFSESGNVVTSTCYFLTFAPRNSNSESESKGKSGASTRTSVKQRLSSAQQQLKDLNKKHI HFKEQGNVVMSLYNLAKYMARNGNNEAESRGRVGANGRANGKQRLTAAQQQIKNLIETHI VFREQGNMVMSLYNVL--MAR-SNSNSESEARPSTSNKANQKQRLTNSQQQLKDLAQTHI QFREQGNVVMSLYNLAKYMARNTNAETESRGRPTSSGRTNGKQRLTAAQQQIKNLIETHI RFKEQGNVVMSLYNLAKY--------MDSRGRTVSNGRANGKQRLTAAQQQIKNLIETHI HFKEQGNVVMSLYNFAKYMARNTNSETESRGRATSGSRTNGKQRLTAAQQQLKNLIETHI QFKEQGNAVMSLYNLAKYMARNSNTETESRGRPTSSGRANGKQRLTAAQQQIKNLIETHI ------------------------------------------------------------ TAAETPSVPRELYRYVSYRSRDRRSTPRTCHKPAANTRSNGKQRLTVAQQQLKELVRTHI ------------------PPRNSNSESESKSRNSSNTRSGGKQRLTAAQQQLKELVKTHI IGNEIPSLTNEVKYWIGSAIRKSASESESNTNTSSNSKISQKARNQLALQQQQQYLAKHI TFAERGNILTSAYNAVRLPPKNSNSESESRTRGATTTRNNGKQRLTTAQQQLRDLTKTHV EGIEVPNLWNELIYSTGYALRKSASESESKQ--PSNSRASNKARNAAAQAAQQEFLLKHI IGKEIPNLINEIKYWIGTANRKSASESESNTNTSSNSKISQKARNQLALQQQQQYLAKHI KGREIPSLYNEVMYWTGYAGRGSASESESNTRNSGNSKTSQKMKNQLALQQQQNYLQRHI TGIEVPSLFNEIGYLIGSAPRKSASESESNTNSSSTSKTSQKARNQLALQQQQQYLAKHI SGLEVPSLKNEVLYLMSLPPRRSASESEAKT--GTTSRAANKARNAVAQAAQLELLSKHI ENEETPSLWNEVKYQTGIMARKSASESESNKYSGTGTKSSQKAKTQAAIQAQQLFLSKHI NSSQVPNLINEVRYRLGYMPRRPTSETETKQPV---SRSANKARSQAAQSAQQEFLARHI NFNEQGNIIMTLYNFSYYMARTSNSESEAKTSKNSGARNTAKQRLTAAQSQIKNLVKTHI LGKDAPLWIYHLKQILWYMP-KTKTSSEVASTPATSAAALQKEKERADKE--REMLEKQQ TNNDPTLEEKPHPLDFEQYSEEFIRAYKDHFGLNVPDQMTLQGYLLGSELGKRTISYKRN HNNHPKNEPLPNPMDFEQYSDEFLRRYKDRFQLKSPDNLSIQGYLLGSRIGKHTYSAKRN TNNHADLRPTSHPVDFEEYTDAFLRRYKDHFQLDVPDNLTLQGYLLSSKLGAKTYSYKRN TNNHPSLIPKSNPVDFQEYPDEFLRKYKDNFHLDVADNLTLQGYLLGSQLGSKTYSFKRN TDNHPDLRPKSHPMDFEEYTDAFLRRYKDHFQLDVPDNLTLQGYLLGSKLGAKTYSYKRN TDNHPDLRPKSHPMDFEEYTDAFLRRYKDHFQLDVPDSLTLQGYLLGSELGAKTYSYRRN TDNHPDLRSKSHPMDFEEYTDAFLRRYKDHFQLDVPDNLTLQGYLLGSKLGAKTYSYKRN TDNHPDLRPKSHPMDFEEYTDAFLRRYKDHFQLDVPDNLTLQGYILGSKLGAKTYSYKRN ------------------------------------------------------------ HNNHEENFPLLHPLDFEAYSDDFLRRYKDHYQIPLQDNLSLQGFLLGSELGSRTYSYRRN HSNHPDNTPQPHPANFESYSDDFLRRYKDHFHLPLEDNMSIQGYLLGSDLGTKTYSFRRN NSNGPQDKPKLQPLDFTTYSDTALLKYSERYGFNFSRIDSLNSDILNSEIGKKTYSKRSK HNNHPENFPKPHPLDFEPYSDEFLRRYKDHFNLPLEDNLSLAGYLLGSQLGEKTYSFQRN NSNGPHDRPKPHPLDFNSFSEETLEKYNKKYGLNFPPPLSINGHILSSEIGKKTFTAKNN NSNGPQDKPKLQPLDFTTYSDTALLKYSERYGFNFSRIESLNSDILNSEIGKKTYSKRSN NSNGPKDKPRIDPLDFETMDDSILLKYSERYGFNLPRPESLNSDILNSEIGKKTFTKRKQ NSNGPQDRPKPTPLDFATYKDEALLKYSERYGFNFSRIDSLNSDILNSEIGKKTFSKRSK HSNGPNDKPKVDPLDFVALDDDALTKYSSKYGLNLPPIESINENILQSEIGKKTSSAKKL NSNGPQDQPKIHPLDFEKFDEETLVRYNKKYNLNLPNPVSINNDILNSEIGKKTYSKRNK NSNGPQDKPKVHPLDFSSLPDKAIRSYMTKHSLQYPEPSSLNADILNSHIGKKTHSYKKS TNNHPGLKSRPHPLDFEMYSDDILRRYKDHFKLGTEDNLTLDGYMLGSQLGSRTYSGELN QLNQPPATTAGEAMNFDTLPLESLRKYKSLHKLQAPSALTLNGYLLSGPMGKKTWSYK-- VPGHRITKTEAASKIKKHFNSLSIKETECIPNFIYKVRNQKKKFKMEFSMLARLSAGAGV QPDARVTKQELAKGVREHFDNYTVREAECLPQFIYKVQNQKKKFRMEF---MSFGSRVLL THDARIHKKDLANVVRRHFDEHSIKETDCIPQFIYKVKNQKKKFKMEFMSTLIFGYKIVP DIDARVTKPTLAHEVKKHFTQYNVKESDCIPKFIYKVKNNKKKFKMEF------------ THDKRIHKRDLANVVRRHFDEHSIKETDCIPQFIYKVKNQKKKFKMEFMNSLIFGHKIVP THDKRIHKKDLANVVRRHFDEHSIKETDCIPQFIYKVKNQKKKFKMEFMNSLIFGQKIIS THDKRIHKKDLANVVRRHFDEHSIKETDCIPQFIYKVKNQKKKFKMEFMNSLIFGHKIVP THDKRIHKRDLANVVRRHFDEHSIKETDCIPQFIYKVKNQKKKFKMEFMNSLIFGHKIVP ------------------------------------------------GPLIDYQSRFYL IPDSRVTKKQLADEVRRHFTASMVKETECIPAFIYKVKNSKKKFRMEFSAQAVWGGRALS QPDSRVSKRELAMEVKRHFTAYSVKETECIPAFIYKVKNQKKKFRMEFSLAS---GRTLS KDTGRISKLEIANHVKNHFSSLPAKENDIITGFLYKVKHQDKEFKLTFSLALRFGVASIQ QSDARVTKKKLALEVKKHFTAYTVKETECIPAFIYKVKNQKKRFKMEFMSFTRLGGERLI K---KISKPELSNNLKKHFLALPCRENEIIANFIYTVRNEDQDFKLSFSLAFRLGAPSLS KDTGRISKLEIANHVKNHFSSLPAKENDIITGFLYKVKHQDKEFKLTFSLALRFGVTSIQ LQGGRISKKEFANHVRNHFLSLTAKDNDIITGFLYKVKHQDKEFKLTFSLALRFGVASLQ KDNGRITKTEVASHIKNHFAGLPAKENDIITGFLYKVKHQDKEFKLTFSLSLRFGVTSLQ KGAHRISKPEYASEVSKHFAAVPCRENEMIANFLYKVKNEKKTFKLTFSLALRFGPASST STFGGITKPEMANHLKTHFMNLPTKENEILTNFLYKVKHQDNDFKLTFSLSLRLG-SFLN S---LMPKRELAEKMRDHFLALPFRENEIITNFLYKVKNQDRDFKLTFPLVALAGEAVVR KPEARVLKKDLADEVKKHFLSYGIKETVCIPHFIYKVKTQKKKFKMEFVIKSLFNTETCN -HRTRVNKPELASAAKKHFMAQPVRESEIIVDFVYAVKNHDKAFKLQFQLTKPFVSAQIP GSQAVTLGLAGQAIPALLGKLLGDTEAEETGFFD-NGILLAAPKKKVSHQKKRQRLLAGK ETATSWSTPAA--PQKLLELLENQREKSPQDYFTNNGILLAVPKKKVSHQKKRQKLYAGD ANVIGWLAPLGSIHEWLRKKLLGDGKGRDKDFFSNNGILLAVPKKKVSHQKKRQKLYGGK ------------------------------------------------------------ TTAIGWLVPLGSIHRWLREKLQQDHKDEDKDFFSNNGILLAVPKKKVSHQKKRQKLYGGK ANLIGWLTPLVYMHEWLKKRLLGDHEGKEKDFFSNNGILLAVPKKKVSHQKKRQKLYGGK ANVIGWFTPLGSIRDWLRNKLQRDHKEEDRDFLSNNGILLAVPKKKVSHQKKRQKLYGGK ANVIGWLTPLGSINRWLKEKLQGDHNEENEDFFSSNGILLAVPKKKVSHQKKRQKLYGGK -SATTWVKPSGSLRKWIDQRTKNEEGSVEEDFFSNNGRLLAVPKKKVTHQKKRQRLYAGK ECTAALELGSGIAPRTLLELLRAGGSQAGTAAVGADGLVLAVPKKKVSHQKRRQKLYGGK ATAISWAIGGSQLPQRLSELLERSEKQPEQDFFSNNGILLAVPKKKVSHQKKRQKLYGGK EALWGLPSITISTTDERLQELKKIEESGEAPFMIDNGILKAVPKKKLSRARRRKKLYAGN TPL-AWSVAWQSILPRLFQDLLKRGKGPSSVGETDNGIFLAVPKKKVSHQKKRQKLYGGR GGWMGLPAISIIQNDRRLQELKQIENNGEAPFMIDNGILRAVPKKKPSYRRTRQKLYAGD EALWGLPSITITTTDERLQELKKIEESGEAPFMIDNGILKAVPKKKLSRARRRKKLYAGN ESLLGLPQISIQHMDPRLAELQQLENSSQSPFMIDNGILKAAPKKRTSYRRKRMKLYMGN ESLWGLPSITILPMDERLRELKKIEESGEAPFMIDNGILKAVPKKKMSRARRRKKLYAGN GSVISILPLLPISLDPRLEELKKLQEGGQPPFMIDNGILKAVPKKRPSHRRTREKLYSGD EALLGLTLGLGIARDSRLDDLKQIEANGQPPFMIDNGILRAAPKKKMSHRRHRTKLYTGD IPVPSWMA---MPRDPRLEELRQMENNGDPPFMIGNEILKAVPKKKPSYRRTRQKLYAGG SLVNTWSVESGEPNNW--------------DIFSNGGMLLAVPKKKVSHQKKRQRLYAGK VAVVTLLGGLFLETPSREVDLEHKHEDD-------HGIVYAVPKKKVSYGQKRKRFLADT KHVNMMNHLNRCPSCGHYKRANTICMHCFENVRFLWKSYTQEQRQEPIQEQNLTDLDKRV KQLKMINHLNKCPSCGHYKKAHTLCMHCVGEIRHIWKAHTNVEQVEPIQEQELSELDKRI KQLKMIHHLNKCPSCGHYKRANTLCMYCVGQIRHIWKTHTAKEEIKPRQEEDLSELDQRV ------------------------------------------------------------ KQLKMIHHLNKCPSCGHYKRANTLCMYCVGQISHIWKTHTAKEEIKPRQEEELSELDQRV KQLKMIHHLNKCPSCGHYKRANTLCMYCVGQIRHIWKAHTAKEEINPKQEKELSELDQRV KQLKMIHHLNKCPSCGHYKRANTLCMYCVGQIRHVWKMHTTTEEVKPRQEEELSELDHRV KQLKMIHHLNKCPSCGHYKRANTLCMYCVGQIRHIWKTHTAKEEIKLRQEEELSEVDQRV KQLKFIHELNKCPSCGHYKRANCSCMHCVQHVRHIWKTQTVKERQEPSQEQELSDLDKRI KQLQMVHHLGKCPSCGHYKRLNTLCMYCVGEIRHIWKVYTQTKPAEPPQEQDLSELDKRI KQLKMIHHLNKCPSCGHYKRANTLCMHCVNEIRHIWKTQTTENPQEPAQEQELSELDRRI KQVHPINNIVRCSACGSVKRSHFMCMNCFAEIKTFLKSLKRKGIIKDNPQSDLNPLDERV KQLQMIHHLNRCPACGHYKRANTLCMHCVGEIRHIWKTHTVQKPQEPLQEQNLSDLDKRI KQIKHLDNLGRCPACGHVKRSHFMCMHCFAEIKSFLKMKKKAQDPVEAPQANLDPIDEKI KQVHPINNIVRCSACGSVKRSHFMCMNCFAEIKTFLKSLKRKGIIKDNPQSDLNPLDERV KQVQPLFNIVRCPACGAAKRSHFMCMNCFAEIKTFLKKLKREGLIKDNPQKDISPVDERV KQVHPINNIVRCSACGSVKRSHFMCMNCFAEIRTFLKSLKRKGLLEENPQSDLNPLDERV KQIQPLENLGRCPACGHVKRSHFMCMHCFAEIKAFLKAKKKALGEPEVPQSNLDPVDEKI KQMHPLNNIVRCPACGHVKRSHFMCMHCFAEIRTFLKGKKREGLIKDNPQSDLDPVDERI KQVQHLDNLVRCPACGHFKRSHFMCMHCFAEIRDFLKMKRKQFPVEENKYPELDSVDEAI KQLKFQHHLNRCPSCGHYKLANTLCTNCVQEIRHIWKTHTNKKVEDPIQEQELSELDRRL KALKPLTNLNRCPACGHVKRMHTLCMHCFYELRSFFAKKTRDSLVDKKQPPTLPAHDEAF LYPGKMDTVYEEKLKDKDYLVRRMRTLPKEMEKFSNWRDKGTGIAPFLPPPVPSKVSVVL LYPGRKETEYTKKLKDKDYLERRMKTLPVEMEKYSSWRDEGTGIPPFLPER----GLPSA LYPGKKETKYAKDLKDKDYLERRVRTLKKEMEKYTTWRDNGTGIAPFLPNTVRSSIATAC ------------------------------MEKFTDWRDKGTGIAPFFPPPTSKVLNSVV LYPGRRDTKYTKDLKDKDYLERRVRTLKKDMEKYTNWRDNGTGIAPFLPNTIRSKVMTAC LYPGKRDTKYTKDLKDKDYLERRIRTLKKEMEKYTNWRDNGTGIAPFLPNTIRNSAMAAC LYPGKRQTKYAKDLNNKDYLERRIRTLKKEMEKYTNWRDNGTGIAPFLPNTIISRMMTAC LYPGKRDTKYTKDLKDKDYLERRARTLKKEMEKYTNWRDNGTGIAPFLPNTIRSRVMTAC LYPGKKETEYNKKLKDKDYLERRMRTLPVE------------------------------ LYPGREETEYMKKLKKKDYLEKRMRTLPVDMEKYSEWMDKGTGIKPFIPVS--ATNRSNV LYPGKKDTEYMKKLKDKDYLERRLRSLPVEMEKFTDWRDKGTGIAPFLPQTPLSGVRRIA IYPGKFETDHERQLKAKEWVPKREKPMPYDMEKFSSWRDKGTGISPFMPQKLPSLLSVAS LYPGRKETEYQKKLKDKDYLDRRMRSLPVKMEKFTNWRDKGTGIAPFLPTPPPNGVKAFF VYPGKHESEYERRLKKKDWIPVREEPLMFNMEKFSNWRDKGTGISPFMPIPEPMLFMIVP IYPGKFETEHERQLKAKEWVPKREKPMPYNMEKFSSWRDKGTGISPFMPQKLPIILSVAS IYPGKVESAHARELKKGEWIPKREEAVLYSMEKFSTWRDKATGISPFMPQQFPKFILIII IYPGKFETDEQRRLKSKDWVPQREEAGLYNMEKFSGWRDRGTGISPFMPQALPIIASIFY IYPGKYVREYEQRLKKKDWVPKREEPLMFDMEKFSTWRDKGPGISPFMPPESAFAFKFIV LYPGKFVQEDERMLQKKEWIPVREEPLMYNMEKFSSWRDKGTGISPFMPVPLPRTLLLVV LYPGKRVSDHERRLQKKEWIPKREQPMMYEMEKFSNWRDKGTGISPFMPVPVP--SSSSM IYPGKKETEYEKKLNNKDYLKRTIKTLPVEMEKFTDWRDKGTGIAPFLPPTIKGIGLQIV IYKNKIDRPHYDKLKDTAYVLKYPRSQVYKMEKFSQYRDKGTGVAPYLPHPRSSTIFVVL NVAWYSVKMVLLLPIMALVMVTGDKFWHRFIYRVLYGLREEIVVVGVKKREVVPWKHPLR NLLHLVVRWLQYVIISLASIILGLDSVYQLRMLSLYKIETDVQVDGVKKRQICKEKHPKP SIVVLAVKAVVALPLILLYSFTKQNVLLGLILKLVFSWKEEVSVQGIKKRDVEKSKHPQK YGFFFMIKIILLLPFIIVNQLTGSKMALTTILKRLFGWSMDVNVIGVKRKAVTKKEHPTA LLGILGVKTIIMLPLIMLYLLTGQNNLLGLILKFTFSWKEEITVQGIKKRDVRKSKHPQK SMVLMVIKIIIMLPLIILYSLTNQNGLLALILKFVFSWKEEVTVQGIKKRDVEKSKHPQK SLVILILKTIIMLPLIIFYLSTGQNSILGLILKFMFSWKEEVSVQGTKKRDVKKSKDPQK LLSILGVKTIIMLPLILIYLLTGQNNLLGLILKFLFNWKEEITVQGIKKRDMKKSKHPQK ------------------------------------------------------------ ALGIWILKAVLLLPLVLIWAVLRGTPLGRWLLQLLVGFEYQVSVDGVKKRDLSTRHLPQR NNGILVLKLIITLPLILILSLTPKKPLWKLLLKLLCNFQVQVTCQGVKKRDLSSKHLPRK KSPIFLIKLPFFIITYLIYTITGFTFILKFILTILFGNRIDFGVDGIKKSQIDKLTSPKK NGLKLSLKLILILPIILVAVVTPSRPLWKLAAILLCNWDVQVSVDGVKRRDQRSKHLPSK KAIVFLMKMPIFVLALGVYFLLPFPVIGRFIILVLFGRNYELTVDGVKKSKTDEINAPTV KSPIFLIKLPFFIITYLIYTITGLNFILKFILTILFGNRIEFTVDGIKKSQIDKLIKPQK RLPIFILKFPLFAITSILYSITGLRFLLSFTFYFLFGQPIDFTVDGIKRSQVSKLEPPQR KLPLFFLKLPFFIIASILYTITGFTSILSFVFSILFGSNIEYSVDGVKKSQSDQLAAPKK SPVLVCVKAPLFVLLYLATYIAP-KPAIKLAFSWLLGKDIDLSVEGIRKTKTEEINRPQL KVPLFIIKLPFFILFTLAYYITSLKPLANFVFFVLFGKNIDFSVEGVKKSNIDVINKPSP ASLVFLLRLPVVILTGLLYVVFPIQIVAKFITLVLLGNRYDLSVEGVRRSKLDEIDRPSV YTLYIALSCILLSPVILLYSISGNSSLLLVILKVLVGWKADIVIQDVKRKDIQPAKHPMK QAPLALIKIPLLLALLALYAGITVRKAYFSTLLFVSGWFWNVSAEAVRRNKLTEAY-PKP NNVYVCNSSSPWDVLLLGLIAPAMFLVPNAGTLYRMNADQYYSYALDAKLFGKEITSFND GCLYVANALSPFDALALRSLVECNFIVPREDSLYTIQLEDWYQFALRIDNRLVEIKDLET GKLYICNCTSPLEALSAVLLAPVSLLVPSNDIVYKVSVKGFFDFILDIKLYGHEVAGLDQ GNLYLVNYQSALDAITLNLLSNPIFLVPDNVHIYKLSLWNFIRYTLNISKYGEIVANINE GKLYICNCTSPLDAFSVVLLAPVTLLVPSNDIVYKVSIREFINFILDIKLYGHEVAELSQ GKLYICNCTSPLDALSVLLLAPVSLLVPSNDVVYKVSVKNFIDFVLDIKVYGHEIAELSQ GKLYICNCSSPLDAFSAVLLAPVSLLVPCNDIIYKVSIKEFIKFILDIKLYGHEIAELSQ GKLYICNCTSPLDAFSVVLLAPVSLLVPSNDIVYKVSITEFIKFILDIKLYGYEVAELSQ ------------------------------------------------------------ GRVYLANFASPLDGLAAAVVSPVLLLVPRGDTLYQFSPWQLGWFALDIPAGQPKLDAAAA GQLYLVNYTSPLDALALYFSSEPVFLIPYAKKLYKLRVLEFIQFTLDGD-NFPTIGQLSD GDLIVTNYITPLDGYFLFLLSQIVILIPNESDLYQYSPLGLINHSFNFSSSGKLVEDVSK GQIYVVNYSSPLDCFVLWFISSIALCIPINDSMHQLSMLEFVSFTLSGNPAHRIVKNVEE GDFVVVNYQSPIDGLILAALSKIAILIPNKEELYQYSIWGLIRYTLGVPTSTIKIGNYSS GDLIITNYITPLDGYFLSLLSKIVLLIPNKSDLYQYSPLGLFNYTFNYNDGGKLIQDLSK GDLIVTNYISPLDGFIMSLLTGVVILIPDKNILYKYTPWTLVNHCF-GQVQGEIVDELSK GDLIVANYITPMDGYFFALLSNIVILVPDKSDLYQYSPSSLSDSTF-AFAVGSKVEDVSK NDVVIVNSISPLDVFILFVVSQIVVVVSSPDGLMRFSVWEYVSFMFDLDSRFPKDSSFKE NDIIVANYSSPIDGLIYALVANVKFLVPNQLELFEYSLWSLVNHSFDNSVLGSKVESLSS GDFVVTNYTSPLDGFFLAGLSKIVLLVPDEKELYEYSIWSFFWLTLDIGVSRSNIADYSK GSIYFCNLSSPLDAILLSLIADLIFLIPDGSVLYKMNLQQLINFIMSPKKFGQEFSQYAQ GEVVVSNYLSPIDAFVYSALFDPVFIVPHASVYQELGPFGVFFKALVPPTHGESLIVFDA CKGYVCFMFLEGTCSNGKSVLPFEITSKQLGERINIFTVQLRLNSSIVTLAIGRREFFLR CNGKVNFLFAEGTTSNGKSVLPFEVQPKLLQDGSKVKSISLKLHAKITTLPKSAFKYKLG LSNTVNFMFAEGTSCNGKSVLPFSISGRKLKEKLELQTIQIKINKTITTLPISNTEYLSR LKKSVNFLFIEGTCSNGKSTLPFNLNSQTLLEQISLQTITLKVNGPLATLPVSKGTYLMR LGNTVNFMFAEGTSCNGKSVLPFSITGKKLKEKFELQTIQIKTNKTITTLPISNMEYLSR LGDTVNFMFAEGTSCNGKTVLPFGISGKKLKQKFELQTIQVRTNKTITTLPISNMEYLSR LSNTVNFMFAEGTSCNGKSVLPFSITGKKLKQKFELQTIQIKTNKTITTLPISSMEYLSR LGNTVNFMFAEGTSCNGKSVLPFNITGRKLKQKFELQTIQIKTNKTITTLPISNMEYLSR ------------------------------------------------------------ SSGCALFVFAEGTTSAGRGILPFELGDPVLAQADGIYTASFRLSQSLATVPTGLWAYLGR VEDYTAFLFPEGTSSNGKSILPFAVTQEFLDEDWELQTISLKVNTVLVTLKIGSWKYLVR LQNKIVFLFLEGTLSNNKSILPFIKLNSKYSFDFNIKSLVVKLIPNFTLIPHSKLQYFFE LKNQVCYVFAEGTTSNGKSVLPFSITQDFWDSATQVQVINLKINSSLTTLSVGKWRYLLR LKEKLVFCFIEGTPSNNKSILPFMDSVAAIPKAFNFKTLIVKIQPGLTTLPISKRRYFVR LQNKIVFLFLEGTPSNNKSILPFIKLNSKYSFNFIIKSLIVKLKPNFTLIPHTKLQYFFE RKRNAIFLLLEGTTSNNTAILPFIKLDPKYKFDFQIKTLVMKLFPQYTLISNASLYYLFE FKKKIVFLLLEGTPSNNKAILPFVKLNPKYSFEFNIKSLVLRISPTFTLIPNGKLQYFFE LEGKMVIFFPEGTSTNNKAILPFIQIPESFLSGFSYKTIVLRMYPNLTLVPHTKSQYIRK YKNKVVFLLLEGTTSNNKALLPFVPLSPNYNFGFAVKTLVLKISPGLTMIPVSKLGYLFE YTNKLVFLFAEGTPSNNKALLSFVPNIPPVPARFKFKTIALRIFPPLTTIPVSPFSYLYQ LKNYVTYLFPEGTCSNGKTVLPFNMKQDTLDESLKIKTIYLKGNNTLVTLSSSKFAYLIK SKGRAVVVFAEGTTSNGRGLLPLLHIDFHQLSNTKVIPAGLRLAPQITTLPVTLPMWVFR SIIKGVKAKIKISHEPAKNLDSIRAKLMDDKYKLVSLGIEAKRKFVSEFNKKHK------ CMSQGVRYKVRISEDVRPDVRKLRINLVGDEYKLVGLDFRSKLRFSQVYYS--------- LLNKGVHVKCKINEPQSNDLEELRIALNGDKYKLVSLDVESKRKFVKEFTTDQR------ MLTHHVRYKCKINEPQTKTLDELRIALNGDKFKLVSLGIDSKRKFISEYSKTRR------ FLNKGINVKCKINEPQSDNLEELRVALNGDKYKLVSLDVESKRNFVKEYISDQR------ LLNKGVHVKCKINEPQSDDLEELRITLNGDKYKLVSLDVESKRKFVKEFTTDQR------ LLNKGIHVKCKINEQQSDDLQELRIALNGDRYKLVSLNVEAKKNFVKQFSNDQR------ FLSKGVHVKCKINEPQSDNLEELRVALNGDKYKLVSLDVESKRNFVKEYTSDQR------ ------------------------------------------------------------ LATRGVQYHCRIQGPFKGTTSELRQALAGEGFMLLGLDLKAKRGFLQTWQPSTG------ MSSTGVNYKCKISEPTSGKIDELRTVMCGDKYKLVGLNVASKKRFVKAYGDRRR------ LLTSQKSVRYKMYKFDEFDIAKIRNSFELNSLTSMSLNIDSKNKFIDYYFDHSI------ VSTQGVSYKCKISDRFQPNLEKMRIALCGDKFKLVGLNADSKRKFAAKYGSRKR------ LLTKNSSIRAKIFKHATFDFRLLKHCFEVGQLNLIGLNINQKITFYNYYIDHKV------ LLTSPKIIHYKIYKFDEFNISKIRNSFELNSLTSISLNIDSKNKFIDYYFDHSI------ LLTSTKSVRCKIYKFQGLKLATLRKSFELNSLNAVGLSVDAKNRFISYYFNHDV------ LVANTKNLRAKIYKFDSFNVPQIRKSFELNSLASVGLDIDSKNKFIKYYADHSI------ SLSKT-FVKVRIVPNEKASLNASKVIFAENGLNTVQLGLKEKKDFFTFYRSYTV------ LLTKLTYIKLKCYKFDKFEVVELRKTFALNSLNSIDLNIAEKQKFVAYYKNHDV------ VISHNSYIRAKIINHDRYNIDEASASFELAQLNVISLDIQEKRKFYSYFVDYQV------ ACWKSVTMKCKINNDDKPSLDSIRITINGDKYKLVSLNIESKKKFTQEFKSYRN------ LLSTGWHVSLRFAEPCTNVNNTLVESICVGRLKSIGLGVEGKRNFWKVYNKKKD------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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-------------------------------------------------------MGKII ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IKKKKKEKKKKKKKKKKNIELESERYEIKVREKSDLLTNKIIFHYPFQTISNPPLKKKMV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MLSYAEFCTIG---------------------------------SAMIL--T------- MGLTYKDFCAVG---------------------------------TALII--G------- -----------------------------------------------MIL--S------- -MLSYQELCTFG---------------------------------TSLIL--I------- -MFSYSDFCSIG---------------------------------TAMIL--S------- -----------------------------------------------MIL--S------- -MFSYSDFCAIG---------------------------------TAMIL--S------- -MFSYSDFCSIG---------------------------------TAMIL--S------- ------------------------------------------------------------ VKFTYKDACTVG---------------------------------SALIV--S------- MKITYNDICTIG---------------------------------TALIL--I------- -MMAYKDIVPIG---------------------------------TSLII--G------- MPISYKEVCTIG---------------------------------TGLIL--I------- --MAYKDIVPVG---------------------------------SGLII--G------- --MAYKDIVPIG---------------------------------TSLII--G------- RWMKYKEVVPIG---------------------------------TALIV--G------- -MMSYQEIVPIG---------------------------------TSLII--G------- --MAYKDIVPVG---------------------------------TGLII--C------- --MAYKDIVPVG---------------------------------TGLII--A------- --MAYSDLVPVG---------------------------------TSLII--G------- -MITYADLCSVG---------------------------------TGLIL--I------- ---MPTSASSIS---------------------------------SALIL--C------- ------------------STGF-------------------------------------- ------------------STTF-------------------------------------- ------------------ATTF-------------------------------------- ------------------ASSF-------------------------------------- ------------------ATTF-------------------------------------- ------------------ATTF-------------------------------------- ------------------ATTF-------------------------------------- ------------------ATTF-------------------------------------- ------------------------------------------------------------ ------------------ATTF-------------------------------------- ------------------STSF-------------------------------------- ------------------STCF-------------------------------------- ------------------GTSF-------------------------------------- ------------------ATSF-------------------------------------- ------------------STCF-------------------------------------- ------------------ATTF-------------------------------------- ------------------ATCF-------------------------------------- ------------------ATSF-------------------------------------- ------------------AASF-------------------------------------- ------------------ATCF-------------------------------------- ------------------SSSF-------------------------------------- ------------------ATSF-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LMG----------------VFFA -------------------------------------LMG----------------IFFS -------------------------------------LMG----------------VFFS -------------------------------------IMG----------------VFYN -------------------------------------LMG----------------VFFS -------------------------------------LMG----------------VFFS -------------------------------------LMG----------------VFFS -------------------------------------LMG----------------VFFS ------------------------------------------------------------ -------------------------------------IMG----------------VFFA -------------------------------------IMG----------------VFFS -------------------------------------GLG----------------IIYG -------------------------------------IMG----------------VFFG -------------------------------------GLG----------------VLYA -------------------------------------GLG----------------IIYG -------------------------------------GLG----------------VIYG -------------------------------------GLG----------------VIYG -------------------------------------ALG----------------VIYA -------------------------------------GLG----------------VVYA -------------------------------------ALG----------------TIYG -------------------------------------LMG----------------VFFA -------------------------------------SLG----------------VLYS CQPYDYHLLFNPQA--------TQEQFDLALKHYQVLSTTPMPVLYLLGFVVALGIIGNT NQPYDYNILFNPAA--------TPEHFENALKHYQTLFYTAKPTLYMLGAVAIVGVIGSL NQPYDYHLLFNANA--------TQEHFDLALKHYQILHDTPFPIVVALGVIALIGLIGGT NLAYDYHLLFNANA--------TQEHFDNALKHYQTLYYTGRPVLYILGFVAVVGLLGNM NMPYDYHLLFNPNS--------TQEHFDLALRHYQILHETPLPVIVTLCVVAGIGLVGGT SMPYDYHLLFNPNA--------VQEHFDLALRHYQTLHETPTPVIIALCVVAGIGLIGGT NMPYDYHLLFNPNA--------TQEHFDLALKHYQTLHETPLSVIVTLSVVAGIGLIGGT NMPYDYHLLFNPNA--------TQEHFDLALRHYQILHETPFPVIVTLCVVAGIGLIGGT ------------------------------------------------------------ NQAYDYHLLFNANM--------TQEHYDNALRHYQTLYFTAQPVLYIFGAIAIFGLLGSL NQSYDYHILFNPNM--------TQTHYDNALHHYQNLYYTAPQVLYFFMFVVSLGFIGSL NWPYDLNTLWIHD---------IPEAFDASLRHYQQWGNSPMYVHYTLHAVGLLGLIGHF NQPYDYHILFNPKI--------DQSHFDNSLRHYQTLFYTAPPVLYTLGFVTMIGIIGCL NLPYDVNTLWRQDE--------TGTAFITSLAHYSVWGNSPAYVHHIFHSVIGLGFIGAF NWPYDVNTLWIHD---------VPEAFDASLRHYQQWGNSPMYIHYTLHAVGLLGLLGHF NWPYDLDTLWRHS---------VTDGFDKSLAHYQTWGNAPMYIHYTLHTVGFLGLVGHF NWPFDLNTLWRHD---------VPNGFEDSLNYYKQWGNSPMYIHYTLHAVGILGLIGHF NLPYDYFTLWTFDP----------NGIERSVAHYSAWANAPMRVHHILHVVALLGLSGCF QWPYDLNTLWKHDE--------TGAAFDLSLAHYTLWAQSPNYVHHVLHFVMGLGLIGSF NLPYDLNTLWVHDE--------SGQAFSRSLAHYLVWANTPPYVHHVLHGVICLGMIGCF NQPYDYDLLFNTSS--------TQEHFDSALKHYQTLYSTNPRVLYVLLGVTALGFIGSM NWPYDFFTLWTAAP--------PESRYTASLDHYKAWYDCPMFVYHIHHTVIGLGLIGFF IRIYKPNPDLQ----LFEYASLGLFVLAVCVFITNVKTGIECSI--TGN---WGE----- IRVYKPNPDLQ----LFEYGSLALYVLGICVFLTNIKTGVESAV--YHN---WGE----- IKIYKPNPELQ----MFEYCSLGLYVLAICVFITNVKTGLDCTI--SHQ---WGE----- IRIYKPNPELK----MFEYASLGLYVLGICVFITNIKTGIECTL--TGQ---WGE----- IKVFKPNPELQ----MFEYCSLGLYVLAICVFLTNVKTGIDCSV--SHN---WGE----- IKIFKPNPELQ----MFEYCSLGLYVLAICVFLTNVKTGIDCSV--SHN---WGG----- IKIFKPNPELQ----MFEYCSLGLYVLAICVFLTNVKTGIDCSV--SHK---WGE----- IKVFKPNPELQ----MFEYCSLGLYVLAICVFLTNVKTGIDCSV--SHK---WGE----- ------------------------------------------------------------ IRIYKPNPELQ----LFEYGSLAMYVLGVCVFLTNIKTGINSAH--YGN---WGE----- ARVYKPSPDLQ----MFEYASLGMYVLGVCVFLTNIKTGIESAI--HRQ---WGE----- IKLYKPDEDAK----YFEYGSLGLFMVGVVIYLTNLRTGVNSCL--VEQ---WGD----- IKVYKPNPDLK----VFEYATLGMYVLGVCLFITNVKTGIESAV--SGN---WGE----- IKLYKPSEDAK----YFEYGSLFLYMVGVIIYLTNLRIGVNSCL--AGD---WGE----- IKLYKPDEDAK----YFEYGSLGLFMVGVVIYLTNLRTGVNSCI--VGE---WGD----- IKLYKPDEEAK----YFEYGSLGLFMIAIIIYLTNLRTGVTSCL--SGQ---WGD----- IKLYKPDEEAK----YFEYGSLGLFMVGIIIYLTNLRTGVNSCV--SGE---WGE----- IKLYKPHPEIK----YFEYGTLGLMMVAIVIYLTNLRIGVNSAL--TGL---WGD----- IKLYKPKGDAK----YFEYGSLGLLMVAIIIYLTNLRIGVNSCL--TGQ---WGD----- IKLYKPKEDSK----YFEYGTLGLIVFATVIYLTNLRTGINSCF--VGD---WGE----- IRIYKPNPDLQ----LFEYTSLGLFVFAICVFITNIKTGIECSI--THN---WGE----- IKLYKPSESNK----LFDGGSLFLYMVGVTIYLTNIRRGLASAV--DGN---WGD----- ---------------------VTQNQ---GLAVIASSNIILLVMFLGVILLQ-------- ---------------------VSEAQ---GIAVVASSNIIILIVFAGVLVLQ-------- ---------------------VTENQ---GLAVIASSNIILLLMFSGVIILQ-------- ---------------------VTENQ---GLAVIASSTIILEVVFLGVLFLQ-------- ---------------------VTENQ---GLAVIASSNIILLVMFAGVIILQ-------- ------------------------------------------------------------ ---------------------VTENQ---GLAVIASSNIILLVMFAGVIILQ-------- ---------------------VTENQ---GLAVIASSNIILLVMFSGVIILQ-------- ------------------------------------------------------------ ---------------------VTQNQ---GLAVIASSNIILLVVFVGVLVLQ-------- ---------------------VTENQ---GLAVIASSNIILLVVFSGVLVLQ-------- ---------------------VDYQT---GINVMAASQVMIIFVLLGVLLLQ-------- ---------------------VTENQ---GLAVVASSNVILLIVFIGVLVLQ-------- ---------------------VDMPT---GINVMAASQVMIGFALFGVLLLQ-------- ---------------------VDYQT---GINVMAASQVMIIFVLLGVLLLQ-------- ---------------------VDYKT---GLNVMAASQVMIILVLVGVLVLQ-------- ---------------------VDQQT---GINVVAASQVMIIFVLLGVLVLQ-------- ---------------------VDMAT---GINVMAASQFMMVVALFGVLILQ-------- ---------------------VDMNT---GVNVIAASEAMIVLVLVGVLTLQ-------- ---------------------VDMPT---GINVMAASQVMMVVILVGVLVLQ-------- ---------------------VNENQ---GLAVLASSNIIFLLMLVGVILLQ-------- ---------------------VDEHT---GINVIAASQVMIVFVLLGVLGLQ-------- ------------------IGLWYTNYDYQKQLQAFYAEERKEQEAINQRKEEEFKKLSK- ------------------GGLWYSTWEYEQRLDQWRKDQLKESAANQQK----------- ------------------IGLWYSNWDLQKRLKQFYAEEQQEAANAAKPEKAE------- ------------------AGLWYSNYDYQKRLKKFYEEEAIAEANAKAAVLEPKTTSK-- ------------------IGLWYSNWDLQKRLKEFYAQEEREAANAGKKTEKVDN----- -----------------------SHRKSRFGCHCFFX----------------------- ------------------IGLWYSNWDLQKRLKKFYAEEEREATNSGKKTEKVEK----- ------------------IGLWYSNWDLQKRLKKFYAEEEREAANAGKKAEKAES----- ------------------------------------------------------------ ------------------GGLWYSEWEYEQRLETFMAEQEAENSAAP------------- ------------------AGLWYTNWEYQQRLKTFYSEDAKESKD--------------- ------------------GGLYYAQWYDNKLKEEFYRQEAKEAALAAESQAQQEHDIATK ------------------AGLWYSSWEYEQRLEQFYAAEAAASTTADAK----------- ------------------GGLYYAEWYDNRLKVKFFEEEERAALAAASAKTDNLAESEVV ------------------GGLYYAQWYDNKLKEEFYRQEANEAALAAETQAKQEHDIATK ------------------GGLYYAQWYDEQLKLEFYENERREAAAAAEAQAREEESLSKK ------------------GGLYYAQWYDNKLKEEFYRQEAEEAALAAEKQAKQEHDIVVE ------------------GGLYYAEWYDKKIQHEFLEKERARAEARAEAAADAETKEVPS ------------------AGLYYAEWYDEKLREDFFKKEAEAAAAKEEEAK--------- ------------------GGLYYAEWYDAKLKAAFFAEEARLAALQSDAKAQIEPEVETE ------------------GGLWYTNWDYQKRLGEFFAAEQAEQAQQEKQQPES------- ------------------VGQWWAEREDAKLKKKFDDEEK-------------------- ------------------------------KQQKKLAKEEATRKTD----------MVLR ------------------------------AEKTTEPAKTESKKKK---SLSGKFSSKTL ------------------------------KAKKNDKSKGVPKKNNAKKMKPLLPRSNAI ------------------------------AKKVRKDAKKENKKQK---RSFPISYLLPK ------------------------------AKKNDNKSKGAQKRKNAKKSLLRLGHRKPL ---------------------------------------------------LLPRSNALL ------------------------------VRRNDTKSKGAQKRKPAKKPRSNAPNISPL ------------------------------VKKNENKSKGAQKRKNAKKKASFPRSNIFV -------------------------------------------------IVSHTTMLNLY ------------------------------KEPAKGGKKSAKSKKE---RLRAPAGAGLR ------------------------------GKKQAVQDQKDSKKKK---NSLKVSSSVNY GKKDKAQPQGEVIEEVTSATTTTGA-----ASATKGQKKTTKKRKS---TYIRQTQAQIN ------------------------------KPADAKKANADTKKQK---FLRCSRQSQVL GSKGAS------------------------ASGASASSTKAKKKSK---TYHSLSIRSIR GKKDKAQPQVEQIEEAASTAATTG------ASATKGQKKTTKKRKS---IILPILSIKPT SGKRGKKDVVVEEGDVADEADAVIEKDAGSTSVSGKKKSAAKKRRS---QLIAPASTHMI EQKEEAKA----------------------TGASKSGNKSAKKRKS---LPKIIPTLYLR ATASGAEPK---------------------KTEVKKTEKKKSKKKA---FIYPMRPFSLL ------------------------------GESTGVDSKKKATKRK-------------- EVS---------------------------TAVKNDKAKKRKSKKQ---RGASHAVRHTH ------------------------------KKQSTKKSKKESKKQK---GTSLKVIAKPI ------------------------------KEKKDKKESKESKKTK-------------- SRPLA--SIPRVQFYSSK---KSKGKTSGEKK---EHKKIPVWHKLKALTSFTASSLLVV CLPLIASPVRIKHTVQGYSTF------AQQNANKQQKKKIPLWPRIRAFTTFTFSGILVI VVPSIITRTSLFRTAVSSRRLNGTGAASGKSDDKAGSKHKPLWPQVKSASTFTFSGILVI RYPISNNVISSQRFYATERSQTNKTKNHQESNKKEKTKKSTIWPKIRAFTTFSLSGSLVI FPRYNTFSSVITHTSLLRTRLNGTGATSGKKDDKTRNKPKPLWPQVKSASTFTFSGILVI ISQVISRTSLLRKTFSSRARITGTGATSDKKDNKADSKHKSLWPQVKSASTFTFSGILVI IAH----ASLLRGTLLNKTRLNDAGTTSQKKAETAGNKRKPLWPQVKSASTFTFSGILVI ASPVISHTSLLRRTLPGRTRLNDAGATSGKKGEKAGSRLKPLWPQVKSASTFTFSGILVI AKRSPMAPNEITSSLLKPRVLAENGSSNDQQNKKKNKIG--IWPRIKSFTTFTVSGTLVV VNVGKMPAWQVANGQPYSTFY------PPEQANRQKERRVTAWKKVRAAATFSASGMLVL ALKLS--PIVSTKSFSSKYYSNAKSNPNSNSNTTRNTKKTPLWSRVKAFTSFTASGVLVV LKPQALLLNLLLHHHHHHHHYTAPPPPPPPQPQDKNAKGKKILNRINRAFTFSLSTLLVV TARVLAGRLTKLHNYSTFNASKTNGSQPKK--------SKPLWPRIKSFASFTISGVLVI HNRLEARTNILNRNILPYKNYTAPPPPPPPPPHDKNAKGKFLFNRIGRAFTFSLSSVIVL YINSQLNKLLLINFHHHHHNYTAPPPPPPPPPGDKNAKGKKILNRISRAFTFSLSTLLVI TRSYLTKPLAITTHKLNHSSSRTAPPPPPPPPSDKNLKGKRILNRISRAFTFSASTLLVI SQPIQQPKLLQTHFYSTK---APPPPPPPPSTHDKNVKGKRLLNRISRAFTFSLSTLLVM NFPTSIPPTSKPVSLMNFSRYTKTAPPPPPPPADKNARGKAILNRISRIFTFSISSILVV -----------FRFYSTKT------APPPPPPHDKNEKGKRILNKATRAFTFSLSSVIVL LLKCTVGPSYPLTSIIFQSKYKTAPPPPPPPPADKNAKGKVLLNRITRAFTFSLSSVIVV YSTALQRSLILSTTNKTYYSTSNANSKKGNQ-----DKKIPLWTRIKSFSTFTASGALVI ------------------------------------------------------------ GGVGVSGVVLYLILSELFSPSGDTMLFNRAVTLVEDNEEVRKLLNDSERLKAYGEVTNDR GATGLAGVVIYLIGAELFSPSGDTQIFNRAVSKVENDEVARRLLNDTERLKAYGELTDDR GAVGISTIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDVRNLLNDGERLKAYGEITNDK GGIGISVIVLYLIIAELFSPSGDTQLFNRAVTMVEKDANVRSMLKDSERLKAYGEITHDR GAVGISAIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDIRSLLDDGERLKAYGEITNDK GAVGISSIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDVRSLLNDGERLKAYGEITNDK GAVGISTIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDIRSLLNDGERLKAYGEITSDK GAVGISAIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDIRNLLDDGERLKAYGEITNDK GAVGLSAIVIYLITSELFSPSGDTRMFNRSVSLVEKDESSRSLLDDD------G------ GAAGVAGIVLYLILSELFSPSGDTQIFNRAVSTVEGDAVARSLLEDGERLKAYGDVGDDR GATGLAAMVIYLILSELLSPSGDTQIFNRAVSLVEADEIARTLLDDSERLKAFGELTDDK GAAGISVLVVSLILSELFLPSGDTRTFNKAVKLIEKNEQAQKALQSGQRLKAYGIVSADK GASGLAGLVIYLILSELFSPSGDTRLFNRAVSMVESDPVARELLTDSERLKAYGEVTDSR GATCISVLVVYLILSELFLPSGDTRTFNKAVRMLESNELAHEALKKGQRVKAHGEQHADK GAGGISILVVSLILSELFLPTGDTRTFNKAVKLIEKNQQAQKILSSGERLKAYGSSSSEK GAAGVAVLVLYLIISELFFPLGDTRTFNKAVDLIQQNEEAQKILTKGERLKAYGIVSADK GAAGVAILVVSLILSELFLPSGDTRTFNKAVRLIEENEQAQKALPNGERLKAYGIVAADR GALGVAGLVVYLILSELFLPSGDTKTFNKAVKLIESNEQAQKALNPGERLRAYGEVPGDK AATGVAVLVVYLILSELFLPSGDTRTFNKAVKLVEKSEIAQELLKPGHRLKAYGEVPGDR GAAGVALLVVYLILSELFLPSGDTRTFNKAVKLVEQNPEAQKLLEPGHRLKAHGGSNGDR GATGISTVVIYLILTELFSPSGDTQLFNRAVTLVEKDEIVRTLLDDTERLKAYGEYADDK ------------------------------------------------------------ WTRNRPIVSTQKIDKYGKCHHFMRFHLESKKKLGLVHVEAVDSEQYKPNFVSMYIDIPGE WTRNRPISSTRRIDKEGKEHYLMRFHVESKQKMGIVHVEAKESDVYQPDFVSMYLDIPGE WTRNRPIVSTKKMDKEGRTHHYMRFHIESKKKLALVHLEAKESKKYQPDFINMYVDVPGE WTRNRPIVSKKKIDRDGVVHHYMRFHVESKKKRALIHIEAKDSKNYQPDFTSVYIDVPGE WTRNRPIVSTKKLDKEGRTHHYMRFHVESKKKIALVHLEAKESKQYQPDFINMYVDVPGE WTRNRPIVSKKKIDKEGRTHHYMRFHIESKKKLALVHLEAKESKKYRPDFINMYVDVPGE WTRNRPIVSTKKFDKEGMTHHYMRFHIESKKKIALVHLEAKESKQYQPDFISMYVDVPGE WTRNRPIVSTKKIDREGSTHHYMRFHIESKKKIALVHLEAKESKQYQPDFINMYVDVPGE ---------------DSKERLK-------------------------------------- WTRNRPISSTRRLDASGREHYYMRFHVETGRRRGVVSLEAQQSDDYQPEFVRMYLDVPGE WTRNRPISSTRRIGKDGKEHYFMRFHVESKQKRGLVHIEAKASEVYQPDFISIYLDIPGE WVRNRPVQSVKTKRKDGKDHLIMKFQVESDNKYGVVSLEQIDNSMWNTEFEYISLDVPGF WTRNRPISSTRRVGKDGKEHYYMRFHVESKQKLALVHVEARESEKYTPDLISMYMDTPGH WARNRPAQSVRTRGADGKDYLFMKFQVESPSKYGTVTLEQVDRTFWSSEFLYIALDMPGN WIRNRSIQSIKFKKKDNKDHLLMKFQVESNNKYGIVSLEQIDNSMWNTEFEYISLDVPGY WVRNRPVQSIKRKNPDGKDHLYMKFKVETATAYGVVTLEQIDDSWWSTKFKYIALDVPGH WVRNRPVQSVKTKHKDGKDHLLMKFQVESDSNYGVVTLEQVDNSMWSTEFEYIALDVPGF WVRNRPVQSVRKKGADGKDHLLMRFHVESNSKHASVVLEQIDTSFWSSEFAYIALELPSK WVRNRPVQSIRTKGQDGKDHHVMKFHVESDAKHATVILEQIDTSFWSSEFAYIALDKPGS WVRNRPAHSIRTKGKDGKDRLVMKFYVDSSSRHGTVSLEQIDLSFWSSEFAYIALDVPGA WTRNRPIASNKRIDKNGKEHYLMRFHVESKQKMGLVHIEAVESEKYQPDFVSVYIDIPGE ------------------------------------------------------------ KRFYIIRPKLRQVVRPKSIFGFPWG----------MTDRLTQLQRCLDQVMEQFCATLNF KRHYLIKPKLS-IVKPKGFLGVNWGSSRGKEECTKMTDRLTQLQICLDQMMEQFCGAVNY KRYYLIKPKLNSVPNSKGFLGIRWG------------------------MTEQFCATLNY KRYYLVKPKLAQVVKPTGFLGVNWG------------------------MVEQFCATLNY KRYYLIKPKLHPVSNSKGFLGIRWG----------MTDRLTQLQICLDQMTEQFCATLNY KRYYLVRPKLNSVSDSKGFLGIRWG------------------------MTEQFCATLNY KRYYLIKPKLNPVSNSKGFLGISWG----------------------------------- KRYYLIKPKLHPVSNSKGFLGIRWG----------MTDRLTQLQICLDQMTEQFCATLNY ------------------------------------------------------------ KRHYLIRPEPS-VAKPKGFLGLNWGTIPTADRRTKMTDRLTQLQQCLDQIVEQFGSAITY KRYYLVKPRVS-IAKPKGFLGVNWG-------------------------MEQFCATLNY KRIYIIEPPLIPIGGGSGFLGLNWG----------MADRLTQLQICLDQLIQQFNSTINY KRYYFVKPQVS-VMKPKGFLGVHWG----------MTDRLTQLQICLDQMMEQFCATLNY KRIYIKEPKFQSLASNDGFLGLKWG----------MTDRLTQLQVCLDQLVEQFNATVNY KRIYIIEPPLIPIGGGSGFLGLNWG----------MADRLTQLQICLDQLIQQFNSTVNY RTVYVIAPPVAPIGKGTGFLGLNWG----------MSDRLTQLQICLDQLIDQFTATVNY RRIYIIEPPLIPIGGGSGFLGLNWG----------MSDRLTQLQICLDQLIQQFNATINY HRMYIVEPKFSPLGKSNGFLGLKWG----------MADRLTQLQVCLDQLVAQFNATVNY KRVYIVEPRFQPLKDSNGFLGLKWG----------MADRLTQLQTCLDQLVEQFNATVNY KRVYIVEPKYQAPGSSGGFLGLKWG----------MSDRLTQLQVCLDQLVEQFNATVNY KRYYLIKPKINRIVRPKGFLGINWG----------MTDRLTQLQICLDQMMEQFCATLNY -----------------------------------MADRLTQLQTCVDQMLTQYFSALTH IDKRHDFEPFND------------------------------------------------ VDKNHGFEPSND------------------------------------------------ IDKNHSFEPLAA------------------------------------------------ IDKNHDFEPFQE------------------------------------------------ IDKNHGFERLTV------------------------------------------------ IDKNHSFEPLTA------------------------------------------------ ------------------------------------------------------------ IDKNHGFERLTA------------------------------------------------ ------------------------------------------------------------ VDRNHDFEPHNE------------------------------------------------ IDKNHGFQPASS------------------------------------------------ VNTSAEPSLLDDDDVNSYSNMAANAPLPQSQQQRQQQKKQQEPQQEIEQ----------- IDKNHDFEPAN------------------------------------------------- VNTNSEPGLLDEDPSSVSNLAANAPIPGPSQGSGGGSNKQTNA----------------- VNTSTEPSLLDDDDVNSYSNMAANAPLPQSQQQQQQEEQQIQQEQQQQPEQQQQLEQLEQ INVHAPPALLD-DDPTSVSNRAAKALPPQGLPGQPGQAGQQLPQDQQLPPAQQQENGKEK VNTNSEPSLLDEDDPNSYSNIAANA-PVPQAQQQQQQQQQQQQQHQQQQQQQQQSQQQSP VNTHSEMAPLDPDPHSVINLAANAPPPGKKDDTSG------------------------- INTSSEPSLLDEDPTSVSNIAASAPLPANQTQQGSTLG---------------------- VNTNCENALLDDDPMSVSNLAAAAPLPGATPAGSNRQTNA-------------------- IDKNHDFETYND------------------------------------------------ INTNHGFKSLA------------------------------------------------- ------KEPKMTDKHASVATPEEFSNGIDELSTDIIVKIRQITTLIDSLPGVGVSAEEQL ------SEEQMSDPQAHIVEEKEFEKNIDELTTDIILKTRQIMALIDSLPGVDVSAQEQL ------NEPQMSDKHATVAPPEEFSNTIDELSTDIILKTRQINKLIDSLPGVDVSAEEQL ------GEPKMSDKHATIAAPEEFSNTIDELATDIILKTRQINKLIDSLPGVDVSAEEQL ------NEPQMSDKHATVVPPEEFSNTIDELSTDIILKTRQINKLIDSLPGVDVSAEEQL ------SEPQMSDKHATVAPPEEFTNTIDELSTDIILKTRQINKLIDSLPGVDVSTEEQL ------------------------------------------------------------ ------NEPQMSDKHATVVPPDEFSNTIDELSTDIILKTRQINKLIDSLPGVDVSAEEQL --------------HATVASPEEYSNTIDELSTDIILKTRQINKLIDSLPGVDVSTEEQM ------LEDKLSDPQATIAAAEDFDRNIDELTTDMILKTRQIIKLIDSLPGVDVSAEEQL ------TEDKMTDPQAIIATTEEYSNTIDELSTDIILKTRQISKLIDSLPGVDVSAEEQM ------PQQQSNPESKSISPPKEFDNVINELCTDLILKSRQIKMLIDSLPGIGVTPNEQM ------GEEKMTDLQANIAPKEDFDNTIDELSTDLILKTRQITKLIDSLPGVDVSAEEQM ------GNSVSNQPSAKAEAESNFENTINELSTDIILKSRQITMLIDSLPGIGVSPESQL QPEQSEQPQQSNPESKTTSPPKRFDNVVNELCTDLILKSRQINMLIDSLPGIGVTPNEQM EQDAA-AKSQAATQVSLEDNENEFNTAIEELSTDIVLKSRQISILIDSLPGIGVSSEDQL TGQAQQSNSGGSKNTTPIQEEANFDNTVNELSTDLILKSRQINMLIDSLPGIGVSPEDQL ------ANSAPSNDVKTEAP---FESVLNELSTDIILKSRQISMIIDSLPGIGTLPETQL ------SNRQTVSPSTQAEAESNFENTINELSTDIILKSRQISMLIDSLPGIGVSPESQL ------ANSVSNQPTAHAEAETNFENTISELSTDLILKSRQITMLIDSLPGIGVAPETQF ------NEQKMSDRHATVAPADEFSSTIDELSTDIILKTRQIIKLIDSLPGVDVSEEEQL ------GEELVKDDTVPVVTDEERERTLEELAKDLVVKSQQIDYLIDSLPGIGSSEEHQM HKIDSLQKKLVDIEDEKIHAIKKKDDLLKQVDDLITVFVGGIADSRRGTSLAPENVQE-- HRIDSLQKQLIKMEKEKIDAIKRKDALQEKVRTLTQDFTIGINESKTEARLV-------- KKIDMLQKKLVEVEDEKIEAIKKKETLLRNVDSLIEDFVDGIANSKKST----------- HKIDSLQRSLVEVEKQKIEAIKKKEKLLDDVDDLITMFVTGIAESRQALTTSSSPLSK-- RKIDMLQKKLVEVEDEKIEAIKKKEKLLRHVDSLIEDFVDGIANSKKST----------- RKIDILQKKLVEVEDEKIEAIKKKEKLLRSVDSLIEDFVDGIANSKKST----------- ------------------------------------------------------------ RKIDMLQKKLVEVEDEKIGAIKKKEKLLRNVDSLIEDFVDGIANSKKST----------- HKIDVLQKELVKIEDKKIAAVKEKESLQREVNDVINCFVSGIAESRQESTTEQ------- SRIDSLQKKLIQVEGEKIEAIKRKESLTKDIEELINEFTEGIANSRRLNKA--------- HKIEALQKQLIKVEEQKIEAIKEKDKLLKSVNSMIGGFTEGIANSRRPVRNYGEKNQS-- NLINELSDKLQAIEEERIQKIKEKDNLLNLLESMIKEVVNGITETRI------------- HRIDSLQNQLVKMEDKKIEAIKEKEALQQKVHEIIYDFTVGIANARRLVKETDRSE---- NMVEDLAKQLEEVEKERIKKIEEKDKLLKWCESLIVEVATGISESRE------------- NLINELSDKLQTLEEERIEKIKEKDNLLNLLENMIKELANGIRETRI------------- KQIGELYNELKEVEQKRLLKIKEKDELIKNVDDLIVELASNMR----------------- SMIYELSGDLKNIEEERIAKIKEKDALLKVLEKLIADVATGISETRM------------- KTITELIEELEKTEKERREKIKEKDELLRWCEELIFNVSGGIYRTRS------------- KIIDDLSKELQSVEQEQVKKIQEKDKLLKWCESLIVEVATGISETRH------------- EMLQKLSKELQDVEKERKEKIKEKDQLLKKCEHLIVQLSNGISTTRN------------- RKIDILQKELVKVEDQKIDAVKKKEKLLQDLNILISYFVTGISDSRQLHNEQTTLIKK-- QQIEKLQKELEHYDQVTEDVIKEKDELLEHCDELILKLAQRKAHIDVESM---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSFFTSLWQSIFEPGTS--PQLIIATHISFAALL -------------------------MTNFVVALWESIFQPGTS--PQLIIATHISFALLL -------------------------MANFFVKLWESVFEPGTT--PQLIIATHASFVALL ------------------------------------------------------------ -------------------------MANFFVRLWESVFEPGTS--PQLIIATHVSFVALL -------------------------MANFFVKLWESVFEPGTS--PQLIIATHVSFVALL -------------------------MANFFVKLWESVFEPGTS--PQLIIATHVSFVALL -------------------------MANFFVRLWESVFEPGTS--PQLIIATHVSFVALL ----------------------SKKAMSFFQNLWGSIFEPGXN--PQLLIXTLLSFTXXI --------------------------MSFFEALWDSVFQPGVP--PVLVGATHVSFTLLL -------------------------MANFFASLWESIFTPGTT--PQLIIATHISFFLLG --------------------------MSFFVELWESVFTPGTT--PALITATHASFILLI -------------------------MANFFEELWLSIFTPGAS--PQLVLATHVSFLFLT --------------------------MSFFVELWESVFTPGTT--PALIKATHASFIMLI --------------------------MSFFVELWESVFTPGTT--PALITATHVSFILLI ---------------------------MFIIDLWESIFTPGTT--PALITATHGSFILLI --------------------------MSFFVELWESVFTPGTT--PALITATHASFILLI --------------------------MAFLVELWESIFTPGTT--PALLKATHVSFVLLH --------------------------MAFLVELWDSIFTPGTT--PALVTATHASFILLI --------------------------MSFIEELWQSVFTPGTT--PALIKATHGSFALLI -------------------------MSNFFVQLWESIFSPGTT--PQLIIATHASFFALL ------------------------------------------------------------ VSLLWLIYSTH-IIHFYFLFVIAFLLWITVIWFIAELKSAKLKSNEELS----------- CVLGSQIYLTK-NIHFIALTIIATLLWITVTWFIYELQNTKLVTNEDLQ----------- LTLMWLIYATHGNIHFYVLFGISLLLWITVIWFISELSLVKLKDNDELD----------- ------------------------------------------------------------ LTLIWLIYATNGNIHFYALFCISLLLWITVIWFINELSHVKLKDNDELD----------- LTLLWLIYATNGNIHFYILFGISLLLWVTVIWFISELSQVKLRDNDELD----------- LTLIWLIYATNGNIHFYVLFGISLLLWITVIWFINELSQVKLKDNVELD----------- LTLLWLIYATNGNIHFYALFSISLLLWFTVIWFINELSQVKLKDNDELD----------- XVLXWLCYXTR-NVHFFASLTXAAFLWASVTWFXNESKXXPLRDNXQLA----------- ALLLALLWTTR-NLHFMALSVIAAFLWATVSWFVRELARAEAKAAPTAA----------- CLLVWLIVLTN-SIHFYALLTIALLLWAIVTWFISELNQLKLKSNQELE----------- ISLLVLIFLTK-SIHFINLLVIAVLLYASVFWFINELQQVKLQSNNELS----------- ACLGWLIFWTK-NIHFIMLLVISTLLWITVTWFVSELKQAQIKDNEELA----------- ISLLSLIYLTR-SIHFINLLVIALMLYGSVIWFINELNQAKLKDNSALE----------- ISLLVLIFLTK-SIHFINLLVIAVLLYASVFWFINELQQVKLKSNDELS----------- SSLLVLIYVTK-SIHFFNLLVIAVLLYGTVIWFISELQKAKLQSNEELN----------- ISLIVLIVLTK-SIHFINLLVIATLLYGTVFWFINELQKVKLQTNEELS----------- LSLISLIYLTR-SIHFINLLVIALLLHGAVIWFVNELKQAKLKDNTELA----------- LSLIALIFLVK-SIHFVNLLVIAVLLYAAVIWFINELKNIKLKSNEELE----------- ASLIWLIYLSR-SIHFVNLLVIALLLYGTVFWFIGELERTKLMSNEELD----------- LTLASLIYTTGGNIHFIIMFALASVLWLTVIWFIYELQSVQLKSNKELE----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TAESKKTDKTEPSKPSEEINLEGV-------------------------- --------------KVATEKKETEATNDGDNKQ--------------------------- ------------------------------------------------------------ --------------KDANKKDDSAIKEDSEDKQ--------------------------- --------------KDANKKDEVVTKNDAEGKQ--------------------------- --------------NAANKKDSNAIKNNEKDNE--------------------------- --------------NDANKKEEVAIKKDSKDKQ--------------------------- ----------KDNGXRAEEEQEDKKEKNTNNNKK--------------------ANQ--- ------------------------------------------------------------ -----------------VEQEKNENQEQPSNKE--------------------------- -----------------QKELEKESESEKLSAN--------------------------- --------KAQKDPPEKANTAAPEASGDEKTEA---------------------TAP--- ------------KEDGSVEIEGAKNETDEKPVE--------------------------- -----------------KKELENHSKAGKLSAD--------------------------- ----------AAKEKKDMNNQENQENQENQGNQERFENL--------------------- -----------------KKGEEPTDEKE-------------------------------- -----------------AETEKVADGEKTESGEK-------------------------- -----------------KEANEQNVAQKTDDSKT-------------------------- ------------------KASENASEKDA------------------------------- ---------------------EPQSQESSA------------------------------ ------------------------------------------------------------ --------------KSTKAE---------------------------------------- --------------AKPDPKPSSTPKKRKTKSRRA------------------------- --------------ENGNTTGSARPAQTHSRSRKA------------------------- ------------------------------------------------------------ --------------ESGKSTSTARRTQAQSRSRKA------------------------- --------------EKGNTTSSAKPTQTHSRSRKA------------------------- --------------EGGNSSSTSRPTQTHSRSRKA------------------------- --------------EGGKSSSAARRTQAQSRSRKA------------------------- --------------XSRTTGTTAAASSAXTXRTKSXXT---------------------- --------------ADEAVATGSWAAPRTAARLR-------------------------- --------------KIEPEAKTTGAKRSATKSRKV------------------------- --------------ATESSQTTATSEDIKLRKRKV------------------------- --------------NSSHAGQSSSLKQNTTKSRKL------------------------- --------------AKSTGAFKDMSKPIPVKKRKA------------------------- --------------ATESSKTTATPEDIKPKKRKV------------------------- --------------DGNTTSVPVKVVGDKPRKRKV------------------------- --------------TDASAESTSVPDPSKIKKRKA------------------------- --------------DNKVASTSATQKSTQAKKRKV------------------------- --------------EEPAASTTATISQSPIRKRKT------------------------- --------------SGRSTATENTGTEKKTTKRKV------------------------- --------------PKVATTTATKKASTSVKSRKA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ---------------------------MITNRLMNKCVSSPLRSV--------------- ---------------------------MLGRFSFGPKFYKSVHR---------------- ---------------------MF---RSLARLGRPRFTFL-------------------- --------------------------MFRSVLTHTNIASSLRTRQIPSAS---------- ---------------------MF---KSVAKLGKSPIFYL-------------------- ------------------------------------------------------------ ---------------------------MIKSVAKLKGFHFSLC----------------- ---------------------MF---KSITKLGRSQCFWL-------------------- --------------------------SRTIAKMFRFAGFNVSKCLRPNMVS--------- ------------------------------MRSQMLALGRAARC---------------- ---------------------------MLGVTRQAKWLFNEGS----------------- --------------------------MFVNKRLLAY------------------------ --------------------------MLASSRGNPLRALFS------------------- --------------------------MFRVKTFTVPSI---------------------- --------------------------MFLNRRLLAY------------------------ ---------------------------MISRWHRATLQ---------------------- ---------------------------MFRRSLQTY------------------------ --------------------------MFRFRPSR-------------------------- --------------------------MLRSQITQL------------------------- --------------------------MTVIRSLNKFSTPK-------------------- ------------------MFRSG---KIISPRNNFFNLIKTT------------------ ------------------------------------------------------------ --------TWRRLITIQTLTTPNENALKFLNKDNELLQTRGSKSIVIKNTDQNLI--SHS ---TVLNPVWQRSIHIKTLTTPNENALKFVSTDGGLLQEKGTQSVEIKNTDEELL--KHA --------NSQRFIHIKTLTTPNENALKFLSADGELLQTRGSKSIVIKNTDENLI--NHS --------LFRRWLNINVLTTPNENALKYMSVDGELFQTPGSKSIVIKNTDNTLI--SNC --------NSQRLIHIKTLTTPNENALKFLSTDGEMLQTRGSKSIVIKNTDENLI--NHS ------------------------------------------------------------ --------NTQRLIHIKTLTTPNENALKFLSTDGEMLQTRGSKSIVIRNTDENLI--NHS --------NSQRLIHIKTLTTPNENALKFLSTDGEMLQTRGSKSIVIKNTDENLI--NHS --------MPRRFIAIKTMTTPNENALKFISTDGEMLQDKGSSSLEIKNSDESLI--EHS --------VARRGLHIKTLTTPNENALKYVSTDGELLQERGAPSVEIRNFDMELI--RQA --------IFKRLLHIKTLSTPNDNSLKFISTDGELLQDRGTRSIEIRNTDESLI--HHS --------IPKRLYHFKTLPTPNPNALKFISPECNILPM-NDKTFEFTTTLQAIH----S --------RGRRFIHVKTVSTPNENALKFISTDGELLQERGKPSVEIKNTDEPLI--KYS --------FSRRFLSFKTLETPNPNALKFISPECQILPI-PSKTFEFTSTLQAIH----S --------IPKRLYHFKTLPTPNPNALKFISPECNILPM-EDKTFEFTTTLQAIH----S --------IGRRLLHFKTASTPNENALKFISPESPILPV-ANTTFEFNSTLQAIH----S --------LPKRLYHFKTLPTPNPNALKFISEECNILPM-EDKTFEFTTTMQAMH----S --------SALRFLSFKTYPTPNENALKFVSPEAEISPL-KNKTFEFSTSLQAVH----S --------FGRRFLSFQTLPTPNPNALKFISPECNILPMAG-KTFEFTSTLQSVH----S --------VFARFLTFQTLSTPNENALKFVSPTKIVPME--NKTFEFTSSLQAVH----S --------YSKRPLHVKTVSTPNENALKFISTDGELFQDRGTHSLEIKNTDDSLI--EQS ------------------------------------------------------------ DLASKIFAQCPGVESLMIGDDFLTVNKD-SQVPWAQIQSDVIDLLTQQLASG-KNVIS-- PFPSKVFQQCPGVEAMMIGDDFVTINKD-ELIHWNQVTPTVIDLLVQHLASG-KPTFL-- KLAQQIFVQCPGVESLMIGDDFLTINKD-RMVHWNVIEPEIIELLTKQLASG-NDVIS-- KLAKKIFEDCPGAESLMIGDDFVSVNKD-SMVHWNQITPEVTKILLNHLQSG-ESVIS-- KLAQQIFLQCPGVESLMIGDDFLTINKD-RMVHWNSIKPEIIDLLTKQLAYG-EDVIS-- ------------------------------------------------------------ KLAQQIFVQCPGVESLMIGDDFLTINKD-KMIHWNSIKPEIIDLLTKQLACG-DDVIS-- KLAQQIFLQCPGVESLMIGDDFLTINKD-RMVHWNSIKPEIVDLLTKQLACG-DDVIS-- NLAQRIFSQCPGVESLMIGDDFSTVNKD-SMVHWNQIKPGVIESLTSQLASG-EDVVS-- PLAEKLFAQVPGVEAVMIGDDFVTVSKD-AELGWAQVTPRVLEVLTQQLASG-QAAVQ-- PLAQRIFTTCPGVESLMIGDDFVTINKD-ELVHWQQVTPSVLDVLTQHLASG-TDAIT-- PLALTLF-KIPGVKSVMLGHDFLTVNKQ-DYINWANLRPEIVEQLDEFLTSKKHPVIT-- PLASRVFTQCPGVEALMIGDDFVTINKD-EMVPWNQITGSVIELLTQYLASG-KEAFA-- PLALKLF-KLHGVRSIMLGEDFLTVNKQ-DHINWAQLRPEVVDLLDGFLTSKKESVVT-- PLALTLF-KIPGVKSVMLGYDFLTVNKQ-DYINWANLRPEIVEHLDEFLTSKKHPVIT-- PLALQLF-KIPGVKSIMLGHDFLTVNKL-DNHDWNSLSPEVMDVMNKFLNSGKVPVVT-- PLALMLF-KIPGVNSVMLGHDFLTVNKQ-DYINWANLRPEIVEHLDEFLTSKKQPVIT-- PLALKLF-KLNGVKSVMIGHDFLTVNKL-DHVNWAHLRPEVVKLLDSFLTSKDEPVIT-- PLALRLF-KIPGVRSVMLGENFLTVNKQ-DHINWANLRPEVVELMDDFLTTKQEPSIT-- PLALKLF-KLPGVRSVMLGPDFLTVNKQ-DHVNWAHLRPEVSSLLDKFLTEKQEPVIT-- KFAQRLFVQCPGIESLMIGDDFVTVNKD-EMIHWNQIKPNVLEILLQQLSSG-ESIVT-- ------------------------------------------------------------ ------DEFHAIKE--DN-EAGYQINEMKFDLTEEDEEIKELIEELIETRIRPAILEDGG ------PDFFDVKK---SSEVGYDVDIPKFEYDEDEQEISEMIDELIQTRIRPAIMDDGG ------EEFHAVQE--EEGEGGYKINMPKFELTAEDEEVSELIEELIDTRIRPAILEDGG ------DDFHAIREASEQAGGGYKVNTPKFEYDEDAQEVSDIIDELIDTRIRPAILEDGG ------KEFHAVQE--EEGEGGYKINMPKFELTEEDEEVSELIEELIDTRIRPAILEDGG ------------------------------------------------------------ ------KEFHAVQE--EEGESGYKINKPKFELTEEDEEVSELIEELIDTRIRPAILEDGG ------KEFHAVQE--EEGEGGYKINMPKFELTEEDEEVSELIEELIDTRIRPAILEDGG ------DEFHTIRD----SDAGYEVTAPKFESSEEDEEVSDMIDELIQTRIRPAIQDDGG ------GQVAVGGT-------------ERFQYDEEEQEISDTIEEIIQTRVRPAIMDDGG ------PEFHTVQE--QSA--GYDVNVPKFELNEEEQEISDMIDELIQTRIRPAIQDDGG ------KELVDEAQ--REA--------------EEESELISMIKELIETRIRPAIQDDGG ------PEFFSVQE--QDV--GYNVDIPKYNYTEDEQEISDMIEELIQTRIRPAIMDDGG ------KELIEESE-------------REIESSEDDLEIVSMIKELIETRIRPAIQDDGG ------KELVDEAQ--REA--------------EEESELISMIKELIETRIRPAIQDDGG ------QELLNKAE------------SERLAEDEDDSELVLMIKELIETRIRPAIQDDGG ------KELIDKAN--EES-------------EMDDSELMSMIKELIETRIRPAIQDDGG ------KELIQQGE------------NDSLSASENDSEVVSMIKELIDTRIRPAIQDDGG ------KELVDQSQ------------QESEVAEAEDSEIVSMIKELIETRIRPAIQDDGG ------KELIEATE------------KEAAEADADDSEIVSMIKELIETRIRPAIQDDGG ------QKFHEISKESESG---YDIQLPKFELNEDEQEVSDMIDELIQTRIRPAIQDDGG ------------------------------------------------------------ DIDFRGWDPE-SGTVYLKLQGACTSCSSSEVTLKYGIESMLKHYVDEVKEVIQM--MDPE DIQYRGWNPE-TGTVYLKLQGACKSCSSSEDTLKHGIEAMLKHYIEEVEDVVQI--LDPE DIDYRGWDPK-TGTVYLRLQGACTSCSSSEVTLKYGIESMLKHYVDEVREVIQI--MDPE DVDYLGWDPK-NGTVYLRLKGSCSSCSSSEVTLKYGIESMLMHYVDEVKEVIQL--LDPT DIDYRGWDPK-TGTVYLRLQGACTSCSSSEVTLKYGIESMLKHYVDEVKEVIQI--MDPE ------------------------------------------------------------ DIDYRGWDPK-NGTVYLKLQGACTSCSSSEVTLKYGIESMLKHYVDEVKEVIQI--MDPE DIDYRGWDPK-TGTVYLRLQGACTSCSSSEVTLKYGIESMLKHYVDEVKEVIQI--MDPE DIQYRAY----------------------------------------------------- DIQYRGWDPE-TGRVYLKLQGACKSCSSSEVTLKHGIESMLKHYVEEVSGVEQV--LDVE DIQYRGYDPK-TGTVYLKLQGACKSCSSSENTLKHGIESMLKHYIEEVEEVVQI--LDPE DIELKGFDEE-TGTVFVKLQGACKSCSASEDTLKHGIESMLMHYVEEVKEVIQI--LDPE DIQYRGYDPE-NGSVYLKLQGACKSCSSSEVTLKHGIESMLKHYIEEVQNVVQI--LDPE DIEFKGFDEE-TGNVFLKLQGACKTCSSSEDTLKNGIEQMMKHYIDGVQEVIQI--LDPE DIELKGFDEE-TGTVFVKLQGACKSCSASEDTLKHGIESMLMHYVEEVKEVIQI--LDPE DIEYKGFDEE-TGTVFLKLQGACKSCSASEDTLKGGIESMLMHYIEEVKEVQQI--LDPE DIELKGFDEE-TGTVFVKLQGACKSCSASEDTLKSGIEGMLMHYIEEVKEVVQV--LDPE DIEYKAFDEE-TGTVFLKLQGACKSCSASEDTLKGGIESMLMHYIEEVKEVVQI--LDPE DIEYKAFDEE-TGTVFLKLQGACKSCSSSEDTLKHGIESMLMHYIEEVREVVQI--LDPE DIEYKAFDEE-TGTVFLKLQGACKSCSASEDTLKHGIESMLKHYVEEVQEVEQI--LDPE DIQYRGYDPK-TGKVYLKLQGACKSCSSSEDTLKYGIESMLKHYVEEVEEVIQI--LDPE ------------------------------------------------------------ QEIAL---KEFDKLEKKLQSKDENDGTTAP-----------ASAS--------------- EKIAL---AEFEKLEKKLESSKR------------------------------------- QEIAL---KEFDKLEKKLESSKNSRDA--------------------------------M QEIAL---KEFDKLEKKLSTSENDKSSA-------------------------------- QEIAL---KEFDKLEKKLESSKNTSHEK-------------------------------M -----------------------------------------------------------M QEIAL---KEFDKLEKKLESSKNASHDA-------------------------------M QEIAL---KEFDKLEKKLESSKNASQNN-------------------------------- ------------------------------------------------------------ EQVAL---HEFGRLEERLRARTSK-----------------------------------N EEIAL---KEFEKLEKKLESRGAEA----------------------------------E EEIAV---KEFERLEQKLKNGNSQGEQA-------------PPSL--------------- EQIAL---KEFEKLEKKLHSGVA------------------------------------- EEIAL---KEFDRLEQKIKQKSQDSP---------------PPSL--------------- EEIAM---KEFERLEQKLKNGNSQSEQA-------------PPSL--------------- EEIAM---KEFERLEQQLKSRASNVTDEA------------PPSL--------------- EEIAM---KEFERLEQKLKKNGSQEDQA-------------PPNL--------------- EEVAN---REFERLEEKLKTKKDPSP---------------PPSL--------------A EEIAL---KEFDKLEQQLQQKRLSQQNEVP-----------PPSL--------------S EEIAL---KEFERLEQNLKSKKNAEASP-------------PPSL--------------- EQIAI---KEFEKLEQRINNSKKV------------------------------------ ------------------------------------------------------------ MIDNSNILQ--LITICLRLSNIVGLMSLIIAKYYLP---DFLRYGKTFTFAKNGNE---- ----MDIFQ-----ILLYSTFYVGIISVFVAEFYIP---QLLKYGKTWEASNN------- YPDGEQLLL--YIVCAYRLSFFIGICSLFIAKICLP---EFLQYGKTYQPKGTSKCL--- -MSTDTILN--LLVIGYRSSFFLGLLSLAIAKFYLP---DFLQYGKTLNTAQSGDVM--- YFDEEQLLK--YTIYAYRLSFFVGICSLFIAKSCLP---EFLQYGKTYRPKENSKYS--- YSNKDRLIQ--CIIHAYRLSFLIGICSLFMAKSCLP---EFLQYGKTYQPNNDTKFS--- YRNGEQLLQ--YTIYAYRLSFFIGFCSLFIAKSFLS---GFLQYGKTYQSKKNSKYL--- ------------------------------------------------------------ ------------------------------------------------------------ SQHMNQMLPEVYVWHLIHFSYGIGLFSLWLAKYRLP---KLLQYGKTRQKKLV------- EGDMDRAIK--CITLLIDASFVVAISCVLLAKWKLT---GFLKYGKTLSVDDKKHDGNEK -----MAIY--DSQLTVVALYSLIIIAIYSAKFITP-LNELLQYGKTVDVREHARLENNL ---MPTLLD-----AAFYASFLVGIASVHLAKWQLP---ALLKYGKTLEGSRTQK----- --MVKRPLE-----KLIGSFYVITLICIFLIKYIKT-LNCLLKYGKNYENPQSKS----- -----MAIY--DSQLIVVSLYLLIIIALYSAKFITP-LNELLQYGKTSNVKKHDQPENSI ----MNFSD--QIQLLICFIYGLLISSILLVTFAQP-LRTLLKYGKNLQVSGNKSSN--- -----MSIH--QLQILIVILYLIIVGSIYAVKLIKP-LNELLHYGKTS--TVNGSESSSI CILLHTSVFGMLVCQAITAGFAAASALILFTKLYTP-LNQLLAYGKVAQGPKSTQTGFA- SSNWQRWGQDVLLYHIVLGGYVFMTANVLLVKFIKP-LNSLLLYGKNRTTGDSSENAQNS ------MLQ--LLALAISVAYVGLICGVLIVKFVTP-LNNFLKYGKCYNSKAIANEN--- ----MDLIY--LVTIGYRCSFVIGLLSLFIAKLYLP---VFLQYGKTITKNNKGESNDSN -----------MLQLLAVTFFLSGIVTTLLGNVSPA-IQKLSYYGKTLTQKTNSTL---- ---NIWDKIKNFSVPKSYFAHFYILSSVLALVTLAS------------------------ -------FWYSLTCPKSNFGHFYLLSSIFSIYNLLWI----------------------- ---SILDKIKKYTVPKAYFAHFYYLATFLSSITLYF------------------------ ---TLWDKIIHFTVPKSYFSHFYYLSAILSVSTLYV------------------------ ---SILERIKKFTVPKAYFSHFYYLATFLSLVTLYF------------------------ ---SILERIKKFTVPKAYFSHFYYLATLLSLITLYF------------------------ ---GILEQIKNFTVPKAYFSHFYYLATFLSLITLYF------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---GVIEPWYTSAVPRRYFSHFYVLSFVLATANLYW------------------------ EKRQILDFFESIVVPRAWFSHFYIISTFFSLVNGIW------------------------ IK-QTIGFISKYVVPKAWFVHFYITLFA--LSSLIFLASFNEPISS-------------D ---GLLGFFEQLTVPKQWFTHFYVYSTTLAILNVYC------------------------ ---TIINYLTSITVPKRWFLHFYIVYFGCCGCFLELVQRDSRLNSVITFITSWLPASLEA IK-QTIGFISNYVVPKSWFVHFYITLFA--LSSLIYLASFKEPIST-------------D ---QFVNFVAVKVVPKQWFKHFYICLFSLATASFFYPCHENTIKP--------------A FN-QMIDFISNNVVPKSWFTHFYVTLFTLSSLTFFSTFQQSEIDTS-------------D ---RLVQIASRWTVPKQYFVHFYILFAVLQWLQLPWAK---------------------G KSIKLIDDIFNLTVPKAWFSHYYVLFFV--YCTLIQIVDIYKAAPVT------------N ---WFLQRFLHLTVPKYFFWHFYVLFS----ASMLLIVSFPRRNSHY------------S VN-KVLFKIEHFTVPKSYFSHFYIISTILSIAVLKD------------------------ ------------ALPKPWFIHFYILAAFLGYYSLFIVYDSFSDNHILNGWTDWMDDLVSH ---YPTDILVWQLF-LHSSRRLYETLYISKYTEKSKMNWSHYAVGLWFYSQLNILVYL-- -----RSLLTLSVF-IHSVRRLYECYCVTKW-GQSKIHLSHYLVGIWFYTTLNLGI---- ---YPKYPIVWIIF-GHSLRRLYETLHVLRYTSNSRMNWSHYLVGIWFYSVLLLILNI-- ---YPKYPVVWLLA-FHSLRRLYETLFVCKYTSKSRMNWSHYVVGIWFYTVLHLILNI-- ---YPKFPIVWIIF-GHSLRRLYETLYVLHYTSNSRMNWSHYLVGIWFYSVLLLILNI-- ---YPKFPIVWIIF-GHSLRRLYETLYVLRYTNKSRMNWSHYLVGIWFYSVLLLILNI-- ---HPMFPIVWIIF-GHSLRRLYETLYVLHYTSKSRMNWSHYLVGIWFYSVLLLILNI-- ------------------------------------------------------------ ------------------------------------------------------------ ---FPEDVITSCIF-FHSLRRLVESARVTKWGSESRMHAAHYLVGLWFYSVLNLSVYL-- ---YPGHLIAWLPL-FHSLRRLYESYCISKFGAESKMNISHYLVGIWFYTSLNLIFSI-- PEKFKNLILIHRLLWVQGIRRLTECLTITNFSKTSKMNVSHYVVGLSHYILVTWATYL-- -----QRNLVSLLFLIHSGRRLYETQCVTKYGENSRMHLSHYLVGLWFYSVANWAVFE-- PANYKHYKLIFYLLCFQSFRRLLESMYITKFSSKAKINVFHYIMGLAFYTTISLNCFL-- PEKFKNLILIHRLLWVQGIRRLTECLTVSNFSKTSKMNVSHYIVGLSHYILVTWATYL-- SAAFKNIKIIQILLWLQGGRRLIESYAVTKFSPKSTMNFSHYIVGMAHYILISTATYF-- PVKFKNLMLIHRLLWVQGLRRLTECLIVTKFSENSKMNISHYFVGLSHYILISSATYL-- KLLHTNFGLAWLLLTAQATRRLMESLLLTQWGSKSRMHISHYFVGLYFYVCVAIVSFC-- DVLYKSNKLIHIMLWIQSTRRTLECFTFTKFAANSKINFSHYIVGMAFYALVSLNSYV-- LAKHNNYTIITCILLAQALRRLYESIYVLKPNQLSRMNIAHYTLGLVFYSLMSINCYLG- ---YPKYPISWLLL-VHSLRRLYETIYVSKYSKNSRMNWSHYIVGIWFYSVLHLIVRI-- VQKPLTTLVLLLLGTIQGTRRLYECVYVMKYSRESQMLLTHYLVGMGFYVAVFCSLWATG --RVQRENT---------TARVLPILVMVLASWDQYKNHVVLSKLKKYSLPRSRLFELVC --MLYHGET---------QYSLISVILFIMSSLDQATNHDYLSKLKKYSQPSYGLFKYIC --SLYKNTV-------PSKLNTKAFIIFCIASWDQYRNHCVLARLVKYSLPSGGMFSLVC --CLYFERI-------SPTINISALFILILASWDQYKNHRVLAHLRKYSLPTQRLFKIVC --SLYKNSI-------PNTLNMNAFIIFCIASWDQYKNHVILANLVKYSLPTGRLFRLVC --SLYRNTI-------PSTPNTYALMIFCIASWDQYKNHCILAQLIKYSLPTGRLFGLVC --SLYKDTI-------PNTLNPKAFIIFCIASWDQYKNHCILAKLIKYSLPSGRLFSLVC ------------------------------------------------------------ ------------------------------------------------------------ --QLNSRQRTRSPSTVNKVFGAVGAVGFLLASWDQARNHIHLAHMIKYTLPRRGLFKIVA --GLSKDNK-ITSLSSNSAFQLIALFVFLASSYNQYQNHVYLSQLVKYTNPKKGLFKWVS --GLSTYGS-HQVPNNYTVFDIVLIIGFAICSLLQFQAHYHLSTLVKYTLPD---FKFVS --SKSRSQL--------PLVRFLAVLVFALSSVDQYMNHLHLSKLVKYTMPTYGLFSITT --SLLPYHLIIPVNDAFDLTDKILITLFIWLSIDQFQNHYHLSTLPKYSVPKFGMFQLVG --GLSTYGS-HQVPSNYTVFDIVLIIGFAICSLLQFQVHYHLSTLVKYTLPD---FSFVS --GLWESCS---ASTALTTTDYILIFAYGVAVVQQFKVHNYLANLRKYSLPQ---FKVVA --GLLRYGS--HKVVRYTTFDDLLIVSFGVLSLLQFSAHYHLASLVKYTVPN---FNNVA --GLVVAQE-----ESKRPRQWLAIAFFALFSVDQYNNHRHLAALVKYSVPTFGMFRHVA --SLKELHPFSEVWKLITTADVALFAIFLAALFDQFRNHYHLATLVKYTIPYK--FKLVA --STVSKGL------QFSVSDTILITVYIITAYDQFLNHKHLASLKKYSMPTRGLFSMVA --KLHQGKI-------SKDINIVSLVIFIIASWDQYKNHRVLSELVKYSLPTKRLFKICC VARDMEEWD----FDYNSVGLSIAISLFLVASTLQYLCHVHLSSLIKYSLPTFWPFKITV CPHYLDEMIIYGSLVSY--------GHEFVWPLIWVIASLSISALESRKFYLSKFK-DTE SAHYFDELLIYTSFMLMD----KGSRMLLIHCILWILVNLGTSSFETGNWYQEKFG---Y CPHYLDEIIIYSTLLPY--------EQEFYLTLIWVIASLSISALETQNYYRQKFK-DDH CPHYLDEMIIYSTFLSY--------NAEFIWPLIWVVVSLSISAIETKNFYKSKFV-EEN CPHYLDEIIIYSTLLPY--------EQEFYLTLVWVITSLTISALETKNYYRHKFK-DNH CPHYLDEIIIYSTLLPY--------EQEFCLTLIWVITSLSISALETRNYYKHKFK-DDD CPHYLDEIIIYSTLLPY--------EQEFYLTLVWVIASLSISALETQNYYKHKFK-DNH ------------------------------------------------------------ ------------------------------------------------------------ CAHYFDEIVIYASLAAME----ATTRWSLTVAVIWVCANLGVSAVETKRYYDAKFK-GQA CAHYFDEILIYSSLFGYARVSRGYLADGLKYCLLWVGINLSVSAIETRNYYSHRYQ-D-- SPHYFYEILIYTILLSFAIKDGDMVSVTFFTAWLFVISNLSISSLETFSYYQKKYK-EEF SPHYFDEVLLYLSLTAYTG------SLKLFACLVWVIVNLSTSALETRAWYLKKFP--QT SAHYLDEIILYLIVAMIGNLHESIIDINYILGWAFVAVNLSISSLESYSYYKAKFP--EF SPHYFYEILIYTILLSFAIKDGDMVSVTFFTSWLFVISNLSISSLETFSYYQKKYK-EEF SPHYFWEIVIYTVLFTFSVKERNMISASFLAALAFVSVNLSITSLETYKFYVQKYG-HDF SPHYLYEILIYTVFLIFSVKDSDTTSWTFAAGWLFVTSNLTISSIETFRYYQDKFK-EDF CAHYCDEIVIYFAVTVAAWTREMEVSVALFSAWVFVLVNLSVSGLESLRYYQTKF--DDY SPHYTDEIIIYSVVAAISCKELSFASINYLLCLIFTVVNLSVTSVDTYKYYQQKFG-DKF CAHYLDEIVIYTIVAALALKNQNLVDVNFGLAALFVAVNLSISSRESHEYYK-RFG-TEY SPHYFDEILIYSSFVSY--------NNEFIWLLIWVIASLSISAIETKAYYKDKFR-HQF CPHYTCEALIYMSYIGVSLSTGSTPNYGLLLAPLFTLTVLTTSAKNSKDWYKQKFP--EY VPRYAAIPYIL---------------------MYRYNTPNTPERSKGGNTRSRDSPGVQG RSRWYLIPYVFMDSTQRSPRLPALPPLQSQ--QSTPKKVGNNERRRRPPPPILTSPVTPT VAHYAIIPYVL-----------------------MYRYSKGSPIERTPQKRVSRHGDRPN VPDYSIIPYILMYRSSPSRGPKRTNKES----LPLPKLPPLNTRDAFIDRSIHHVATADD VAPYAIIPFII-----------------------MYRYNRSSPFERTPEKRVSRQESQRK VPRYAIIPYVL------------------------------------------------- VAHYAIIPLIL-----------------------MYRYNMGSILERTPQKRTSPQESHRS ----------------------------------MYRYNKSSPLERTPEKRVSRHESQRK ------------------------------------------------------------ VAPYALIPYIM-------------------------------MYDAYRDRDHDMDETKPK VAPHAIIPFVLFSSEEDAKGVEIEFRPNCGCTLLQINKRNAELTMHSPNRRTDECPNGTN KLKWAVLPGILMSHQPNKKSLRRKPPPIDDSTPFSIYQNLTSNPEQYSDFQVSLSKTPPI TPPYAIIPFVL------------------------------------------------- TVKYSIIPGILGRSNGSKNSLRRKPPPSLDITMNTNRVIPLESTQFFSPHSPAVLEGKSA KLKWAILPGILMSHQPNKRTLRRKPPPIEDSTPFSIYQNLASNPQQYSDFQHALSKSPPI KLRWAILPGIL-MSNSTRKMLRRKPPPLDIDLVLPHSPSRLSSPSPLPQQQQQQQQQPPP KLKWAIMPGILMPNEPIKRSLRRKPPPSDVVDFHSFNATRTQLPTPNSPPSHRPVPPVTT TVQYAVVPFLLMSSSNNKKSLRRKPPPPLNEYQSGLRINTNPGTDHYQSYHANEREQPST KLQWAILPGIL----------------MTGESQFYMNSPKPMGPKELIDYSVLSVPSIHN KAKWSIVPRLV---MPPKKSLRRKPPPDVDDLYTKQPAVPLSPPTLYSKPNNDRCG---- VPNHAIIPFIL---------------------MSSYNYPKTSSQGQYKRPNLVSNRENVD NVRWLTIPGVL----MHPPPLPPKPPAEVINRTDEFRTKLPERVSSLVDKRPSYHPQGPR DVILPKLPPLNTRSSFLESDMMQSDVSIGWTP-------------------------LTE SGSSFTVVPSRSSEKQQPQI---DQQHLYSSPFVTE---------------------VSV SIELPKLPPLNTRNSFLDDSNGTDNVSIGWTPISDNQFQSPIPQTFSF---------ASK TLNTA-----------------ISDLSIGWTPISENVHNPQT---------------PSS SIELPKLPPLNTRNSFLDDSNGTDNISIGWTPISDTQFQSPVPQAFTF---------TSK ------------------------------------------------------------ SIELPKLPPLNTRNSFLDDSNGTDNVSIGWTPISDTQFQSPIPQTVSF---------PSN SIELPKLPPLNTRNSFLDDSNGTDNISIGWTPISDTQFQSPVPQAFAF---------TSK ------------------------------------------------------------ LPQLP---PLVTKAAAGIDH----RTRIAWTPFDDH------------------------ IKLPQ-LPPLNTKKPFTDNAQHKDRITIGWTPINEPTPPQVPF--------------RFE QVNTF-VQSSPPNYIQSPPS-APPPPIPVQRPEYTSVGSFPEAASAPMDQTNYSMSSSFI ------------------------------------------------------------ RLPIW------NNHQQKLS---IDTDNYVYDEESRFDGRQSLIGGGIYDGEYGEEFAESI QVNTF-IQSSPPNYTQLPPS-APPPPIPAQQPEYTLIGTFSEMASTPVDQANYSVSLSFI PPPLPELLPPKPTKPLPPPSSPPPPPTATATAATTTTTKTKTATDMGCLDSSYNISNFIA SSQNIQISASSPNYRPPIPTSPPSIPVSVLDPRISKKPSIPQVTATPPRPVNQSANSSFI ITPAI-IVPEKQNESFDLSFDSPRLKGPKDLPFDEYSPTQLKQGSHA----------NIL RKLHR------------------------------------------------------S --------PIDQKYTHRLGY-------------------PTVDTSVSFNAGDDDSFD--S LPKLP---PLRTKSSFLENRNSEDNISIGWTPV------------------------IGN QLNSD-APQQTNRYLGVYSS----PQAPNWRDEERSERSNTDSSDRTSGS-------ATD NTISTSGQFADEH-IGYGNSPQLRSP-------KSPANRRNSLIYENFNGDSPMSVKSVG SEKRAPAPKVYIS-PFVGDPSVFRSP-------ETLPNSSFSNNSDSPASQSDNNNYNN- HHIRANATSSTESTPKSTKHIKERRP-------PPLLHTNETILLDSPMASPGSWSRERL SHVQSPPSTGPRTGSASNSSKYRSRR---RPPPPQTVLSAGAIPTTATMDSSFRSSNMDT HSARGNGTSSSESTPKSTKYVKERRP----PPPPPLLYSTESIRIDSPMVSPSSQSRERS ------------------------------------------------------------ HQIRGNATSSSESTPRSTKYVKERRP----PPPPPLLRSTESIHTDSPMSSPRSWSRERS HHVRGNGTSSSESTPKSTKYVKERRP----PPPPPLLNSTESIRIDSPVASPRSRSRERS ------------------------------------------------------------ ---ERPTGLGQGK--GLGGARSRRPP------PPPAEGLGVGVPAGHRLSGDGTRPGRTE HTATSQNPLGPLS------PNRNRRP----PPPPVSCDITTTSASPSNIGSPLSITPTIS SMGGSPKPKGPKQIWEYEDDSIISQP----IEYVRHASINSTDYKSRPRGYQQMSTTSQS ------------------------------------------------------------ MSFDSPRPMGPKTLPGFEGYTTPMKQNPNPPYPTNDIQLELDFSEDDYNHSPNDNYNFFS SMSGSPKPKGPKQIWEYEDDSIISQP----IEYVRHASINSTDYKSRPRGYQQMSTTSQS SANTKIPARPKLQMIHMTRASYSEQPSPKPRGPRDISDYENNIYIDDDNEDDNNHNKNST SVSDSIRPKGPKQIWEYEDDEYDGQN-NSLLTPIRNTSVSSIDYKSRPRAYQQISSASKS EVAASLSPQEPSKNSSYVQDPYQDTY--------SPRDYHRDYHKDYQRDDPRDHQREYE SHPNVPYPVDLSE--ELEQGDYEDLP----PEVVLHIDSPTPPPSETPPQASRTQQIINE IIWDSPKPMGPKELPEFLDDSEVDSS----------------------QRYLSSHQRHHE NGVGGSEPNSTGSLSNIGNVNNSDSP--------ISGSRRSISGRPPPPRIPTQYSIPSS RASYSSYSTDRTSIHGGVSGYYNDPNTSSMQSWRPDSERPPPLPLKKPALNTSHRSNPAS NGKSRRRPPPPSLQHSISQLDSYQSSPGSPATPFITKRRTNDFITPTKTKPYKSPFVGEQ -----NRLSSSSTSSIFTNNVTMP---NIEFEGFASDSKDITMKAALPPRTFSGPINAAT PSKLP-FVGDPEIQDYVDDTPNHSTTLKSPFVNDF----------------GSLSLKSPA PTKMKHRSLFSTPVQNTMDNDGSTATLQSSETGNFDQDSVISSQSSPTSPSIRKHHPTHH PNKLS-FIGNSEERHHMEYISNHSRILKSPFANGF----------------SPNSPKSPR ------------------------------------------------------------ PNKLP-FVGDPEERHYIDDISNYARFSKSPFVKGF--------------NSLSSKSQTEG PNKLP-FVGDLEERHHVDYMSNHSRILKSPFVNGF----------------SSHSFKSPT ------------------------------------------------------------ EAHTPERGGTPEAE----EGIIYPSPFGDDTVTMVGPRGSPTGRGSPTARGSPGRLPGSP TLNKPSRIPSIYRSPFVGEDDILSSQEQPISTPSKYKSPFVGDPSDILVKERKSSVIEPS APLDSIEDLSPIQAKPTITTAPYPTQNEDSIDNYYESDYDYTFED-------DSPSQMQS ------------------------------------------------------------ PELTPSRLHYPFNEPNYHQTTPSKNQTTPPNHRTSEIIL----------QSLNTPTKIPS APLDNLEDFLPIEANSSATTAPYPTQNEDSINDYFEDDYDYTFED----DSPSQMQAHQS FLEASNSMQTPSTSILPRSRYQLRRSFQQISRPGAVSSPSQSGISNVDTNSYSTQRQQRQ DASIVPYPTEDTSQSTLESSVPYPTTNFEESLAEYHEPNLGYTFGVPSPSQIRTQEIIDK RNHRRQQDSFSTLSPVFPQTSSSPSVSDLPPGRRYYPPRKFQSLS----SSTSSPFFSRD SIITP-TKISPLRNSIYDTPPSYNGSYSVNDSGLTGSPPRRSSISPARNDTFLSSRKHSP RPQLPPIEDIRLTESFDEPIDPYSRTSQIIADSLN--------------TPSKIPRLHAS PL----------------RIAPTRTKTSTPTSSQY-----------------KSPFVSES PGRAHSQQNTNTPPPLPPQIPIYDTYMEQQAYEDYLENGFYDQQSLYRTPEPQHPARHFT DIEDS-----MLQQSTHFAKVYKSPFVGDLDSDIIISPSNANETTKTRKE---------- KTTATTLQFTGPVEHRYNDMAVPETLPALDAISPISTGNFNWSTSDKSSL---------- DSTKFFSDEFNSRHHEGEKALPPIPSSTTLLLSPFN------------------------ HHHHHGKNDDDITESYIDKILPPIPVLD-------------------------------- DSSKQFSDESDLRCHEREKALPPIPFTTTLLLSPFD------------------------ ------------------------------------------------------------ RKQAHVSDEANRQYHEREKALPPIPSTTTLLLSPFD------------------------ DGGKLFSDELDLRCHEREKALPPIPSTTTLLLSPFD------------------------ ------------------------------------------------------------ VGRSSRRSPSGPQASPVGRGSPGGPRGSPARCAELPDVMFGDEEPALRPL--------PG TFTLSSPQSYNATIFSRAEPLPNVTYDNNSETLDESMRTMKSLPALPPLA---------- VDKYGSPRIDDVPDLTSKRSSLQSAQSVNTSWQSHSQTNSIQSGANSVGILESPPRPATK ------------------------------------------------------------ LNEPNIPVKGHSPRRADRNNSYSDNSGRSSSSSPNSRNSKFSMKMNGIGGHSSPTRSPER VEKYGSPRINDVPDLTSKRSLLQLSQSVNNLWQSHSQTNLIHSGANLAGILESPPRPATR QQQQQQKLPHEIHTPERNLPYPTKPIEDLLAEDIEQGYSFYVDSPSQQRTSNYTPRH-KH VVADSSPQIDDVPDLTSNRNSINTINSRNDSWTSHSRTNSVNSYNKVDYGPNLRHLA--- ESQTDTSSIKGPTPSPPAKPTPPYPVSSDLDLSDSDESSPREEAHLGDIDINRPSRIDLY NRDSR-----DNSKSPKFRSSPSLSYDFPIAQRTFVEGDSDDDEGYSYDT---------- DSLQRPTYDYSVESTPTTSSGMSAPQNILTPQSSSRNLGGSPTTRYDRS----------- DSN-------LLRKSTNNSKIYRSPFIGDDEIKSRSSSPRIWSTPPEEFE---------Q PSPNAYQIPPHLSPGHSSYPPADLPALDTNDWSHVASAYETDNMYPDHAY---------- ---------------------SSRVQSKTISNT--------ELNFYSK------------ ---------------------QNTTLYYPQPPK--------------------------- ---------------------DEDSDFFTKPPP--------------------------- ---------------------SINDFFEAAMPP--------------------------- ---------------------DEDSEFFTKPPP--------------------------- ------------------------------------------------------------ ---------------------EEDSEFFTKPPP--------------------------- ---------------------EEDSEFFTKPPP--------------------------- ------------------------------------------------------------ LSAAREGIPPSVSTVGSRR--DHKPGLHSAAPS--------------------------- KPEVRNGSLPFADLPPQISR-SDADNFYKPPPP--------------------------- NSQNFPPPNTQAID-------YASDSSYSRSPSPTRRTIDRTKTVSSGFTYAESEFIE-- ------------------------------------------------------------ NSPTNGNYMERVYSERRSSRSPSPKKIYGRSPS----LIYDQQPFNGETYYDSTNSLD-- NSQNFPPPPNQGID-------YVLDLSYSRSPSPTRRTIDRTKTVSLGFTYAESEYIE-- STYSFSNEPDIAILPNGQSRSPSPDKLFQRKHNSIISNYQQAEGYFDGHYRNDYNYYSNN -SRNSQTFFYNKTSPKSNRMSYGSDSSYSRSPSPTRPNVDRTKTVSSGFTYRESEYSE-- STQMSKSQRSLSRSPDYKFLGYGAGVAYPSSPESGGNYSSPNSPTKSPSFRYTAESSYSR TRQSATEYSIINQE-------MGGQACYPEEDN--------------------------- ---------------------PSPNQVYARSPSLLYKYEETTPGSDGTDS---------- STKSIPGLSSYNDNI------LDSPTFFERPPL--------------------------- ESPVRMPVADAYMSPGSPS--PLKTETYSPAPSQQSPLHHHSS-------QSSLNYMTTP ------------PQIPLTSSRNITGISRFSDQVESFYSDSNYTFNNSARNSSFNSFLG-- ------------MKDVSNGAIGPNEPRLS-DSISSYYSNSSYAFNKYARHESFGSITG-- ---------------PLSTSRNISGHSRVSESLESVYSDSDYTFNNNARQSSFNSLLG-- ------------PLLLASTSRNVSGLSKNSDSVESYYSDSNYTFNNKRHATEFSSLLG-- ---------------PLSTSRNVSGNSRVSEALESVYSDSDYTFNNNARQSSFNSLLG-- ------------------------------------------------------------ ---------------PLSTSRNISGHSRASETLESVYSDSDYTFNNNARQSSFNSLLG-- ---------------PLSTSRNISGHSRVSETLESVYSDSDYTFNNNARQSSFNSLLG-- ------------------------------------------------------------ ------------SRARLLSDRTFS------ETLSSYYTCSSYTFNEYARHGSFGSVMG-- --------------LNASQSRHTSDGRKFSDSISSYYASSNYTFNNELRQSSFNSILG-- ------------EGYNEFAVQHGPSSRWNSVNSNATHTPENLFWDD-GYQLPTESPATEY ------------------------------------------------------------ ------------ELEDKFDNVHVRQARWN----SFDTGETKSDISDDPYSDMPETTTTNY ------------EGYNEFSVQHGPSSRWNSVNSNATYTPENLFWDD-GYQLSSESPATEY DDSGMT------NEYTAAPSPNLPRSPQLQYRVVSDNPFYIDENDGNYTNADYESPVTDY ------------DGYNEFGIEQGPSSRWNSSRATYNHETDNLFWDE-ELQGESESPATEY SSRSPSPKKGNRRDMNFGVGDDLRTPRW--SLIEQDYTDYYYDDNE-----HHEGDYMNV --------------VDLFDDESIIHPSTF------------------------------- ------------NLWEDYEVEGGEELTLHDRTSAWTDGLGSSLIQDDDLYDDPDTPATNY ------------PKIPSSSSRNMSGNSKVSDSIESCYSDSNYTFNNNARHSSFNSLLG-- QQCSERDLALRMERLDMRPAMERLEPRPMVDRIDM---RPSMDIRPEKRMSLPNGMPK-- --AKPLQYAP----------------------------------------------SVTA --SKPLNNVA----------------------------------------------SITV --AKPLELAP----------------------------------------------SITA --GKPLQLAP----------------------------------------------SITA --AKPLELAP----------------------------------------------SITA ------------------------------------------------------------ --AKPLELAP----------------------------------------------SITA --AKPLELAP----------------------------------------------SITA ------------------------------------------------------------ --GQPLEHVP----------------------------------------------SVNA --GKPLQQIP----------------------------------------------SVTA FDYSMLPELP----------------SVKPLPKSPSYLPEVLASKQQQ---ELPSLPLEL ------------------------------------------------------------ FDYSILPDLPSSPSKRMTLSSTISFLKRDSQPNLPSPTSTTRRRRDDE----LPPVPLDL FDYSMLPELP----------------SVKPLPKSPSYFPDEVLALKQQ--QELPSLPLEL FDYSILPELP---------SKVPTSVERKDFPLPSLPDKPLLTVPRTKEKQELPPLPLDL FDYAMLPELP---------------FTQPVVPPRPAKLPMVPASKQEE---ELPALPLVL FDYTSLPELPQEPLTPINHTAFRSTLSLFRNDSGLQSSPTLRRKYDE-----LPPVPLDL --FGRLPTLPTSPTRNNTFSYSPNRDLMTSITRNSTLYSVSQQRKDED----LPALPFEL FDYSILPDLP-TPSSSPTSSHLRKSPTRRTLAKKDSQFSISRKRLEED----LPPVPLDL --GKPLELAP----------------------------------------------SITA --YQPMSPSVSPSRFNSMPNKRPVPVSAGNTPVKQLDIPEYDILSDSM-RSDTAWVELDL PTQA---FSIDLIDEHKLYQCYSIYRLSDIYEWLLKVFEWFNEYIFEKLDLFQIVQLLLE PTYP---FTIDLLDERKLYQCYNISQLSHIYQWLLKVFEWFNEYVFGKLEFFQIVQLLLE PTQP---FSIQSIDEHKLYQCDNVYKLSGIYEWILKIFEWFNECVFTKIDLFQIVQLLLE PTQP---FNIDLLDENKLYQCYSVFHLSDIYEWILKIFEWFNEYIFGKIEFYQVVQRLLE PTQP---FSIQSIDEHKLYQCDNVYKLSAIYEWILKVFEWFNECVFTKIDLFQIVQLLLE ------------------------------------------------------------ PTQP---FSIQLIDEHKLYQCDNVYRLSAIYEWILKVFEWFNECVFTKIDLFQIVQLLLE PTQP---FSIQSIDEHKLYQCDNVYQLSAIYEWILKVFEWYNECVFTKIDLFQIVQLLLE ------------------------------------------------------------ PTQP---LSIELLSEEKLYQCYCVHKLSDIYEWLLKVFEWFNEYILGKIEFIQLVQLLLE PTQP---FSIDLLDENKLYQCYSVTLLSDIYEWLLKVFEWFNEYVFEKFEFFQMVQLLLE PDLP---FSSAFLQSQHFEICSKIWSLSELFKWCLKLRIWLNNSTISKTELKKALGGLLA ----------------------------------------------------------MK PQLP---FTSSSLAMQHFNACKNIWSLSDIFEWCLKLKTWLHDLFIPKREFKKALIKLLV PDLP---FSSAFLQSQHFEICSKIWSLSALFNWCLKLRIWLNNLTISKTELKKALGGLLA PQLP---FNSASLQEAHFASCPQVWSLSQIFKWCCKLQIWLAELTISRSDLTKAIVRLLA PELP---FSAAFLQSQHFEVCTRIWSLSELFKWCLKLRIWLRDSTISGTELKKALSGLLA PSLP---FSSSSLTSHHFATCKDVWSLRNIFAWCIQLNTWVSGQDISEKQLRKALIKLLV PPLP---FSAKSLNNQHFSVFNPLWSLKSIFEWSIKLQDWLDDLFISLAEFKVALTDLVT PRLP---FSSSSLVAQHLSQCSSVWSLSSVHEWCLKLETWLHDEFISKKEFKKALIKLIV PTQP---FSINSLDENKLYQCYSVYKLSDIYEWVLKVFEWFNEYVFGKFEFFQMIQLLLE PSIP---TRPQVDLSNVTYACPEMWSLSGVRNWIRPF--FTGDKEVPEKDLHTAVSNLFA FQSPTYEQEVIDSNVDRIMSSLINQGAVDNEQEIAVIVAGLISSIFTDLLPCYSFIDSTF FQLPSCEQDIIDSNVDKIIESLILQGATGNQIT--IIIAGLTQGVFTDLLPCYSYSHIYD FQMPNFDQDTIDSNVDNIMASLIAQEAIINDEEVAVVVAGLVTGIFTELLPCYSFIDNTY FQLSSINQDIIDSNVDMIIESLISQSAVETEDSLVIIVAGLVQGVFTQLLPCYSFVDTDY FQMPNFDQDTIDSNVDNIMASFISQKAIINDEEVAVVVGGLITGVFTELLPCYSFIDNTY ------------------------------------------------------------ FQMPNFDQDTIDSNVDNIMASLIAQKAVINDEEVAVVVAGLIVGIFTELLPCYSFIDNTY FQMPNFDQDTIDSNVDNIMASLITQKAIINDEEVAVVVGGLIAGIFSELLPCYSFIDNTY ------------------------------------------------------------ FQLPTYEQEVIDKNVDHIIGSLVKQGAQTRGDI-TIIVAGLVQGVFTELLSCYSLTHKKE FQLPSCDQDVIDSSVDKIIESLALQSAGNSSEEITIIVAGLVQGVFTDLLPCYSHSKKQY FHRRDVPLDVVSNNAAAAFETFVSTGAAQGSDKLIVMNENVLNGVLPLLTECYSNFQHTK QSRP-------------------------------------------------------- FYKRDIPLDIIGQNVDQIIASFLEVKANTNNDEGVIMNSAVVNGVLPDLTNCYCHDEDHK FHRRDVPLDVVSNNAAAAFENFVLSGAAQGSDKLIVMNENVLNGVLPLLTECYSNFQHTK FHRSDVPLNIITRSSQTAFNAFLQAKAATDKGD-VAFNEHIVNGVFPELTGCYSPTPHSK FHRRDTPLDIVSSSARVVFDNFVASGAAEGNDKFVVMNECIVNGVLPLLTECYSNFAHTK FHKRNTPIDIIGKNASGIIETFRSNGADGTKKTFAHFIPDKVSGVLVDLTGCYCHDADHT YHKPDIPPTVLSTLVDSIVDSLLRSHAISPNNAGITIDEMAVSGVFPALTTCYYSGSHDK FHRRNISLDVVGRNVDQIITDFISSGASSGPNEGVVMQRGVVGGVLTQLTDCYCRDRDHT FQMPAFDQDTIDSNVDKIIESLVLQKAEDEENEITIIVAGLICGIFTELLPCYSFSDNTY ANK-TMSPVYAEQYAKHVIGALGRGDVLRHDEEYMFSDEGVVSGVIPALTLCYSKSSHDS NEFDHTICYSTTCLSNESRQEIKVSEIINKSVGL-WTDYWQLSAEELSEINPKEIQRQSF DPTTDLKCYSYTCSENYRS-QLKISEFINKSVGL-WTDYWKLTPEELSEINPKEVKRQSF GPTNSSICYSNVCSSDFRK-EIKISEIINKSVGL-WTEYWHLAPEDLAEINPREVQRQSF HSSNTTQCYSYLCINGPVKKDLKISEIINKSVGV-WTEYWHLTPSDLRDIEPREIQRQSF GSTNSLICYSNVCSSGFRK-EIKLSEIINKSVGL-WTEYWHLTPDDLAEINPREVQRQSF ------------------------------------------------------------ GTTNSSNCYSNICSSGFRK-EIKLSEIINKSVGL-WTEYWHLTPDDLAEINPREVQRQSF GSNNSLICYSNMCSSGFRK-EIKLSEIINKSVGL-WTEYWHLTPDDLAEINPREVQRQSF ------------------------------------------------------------ MNTEEYVCYSKLCMFNETRPLMRVSEVLSRPVGL-WTEYWKLTDEELSEINPKEVKRQSY HEEGLYCCYSARCTRLLKEVELKLSEIINKSVGL-WTDYWKLTPEDLSDISPREIKRQSF EVEQSMTCYSTCCSMNLER-KMRNTNIKDIVLEHDWTSHWHLTVEDLKTLNHATSKQQSL --------------------VLKVSEIINKSVGL-WTDYWKLSPDQLAEINPKEVKRQSF SNSNTLKCYSSECNRVIDHEQLRNTNINEIVLGDDWASHWRLTAEDLRKFDKTVSKRQSL EVEQSMTCYSTCCSMNLER-KMRNTNIKDIVLEHDWTSHWHLTVEDLKTLNHATSKQQSL DEE--SLCYASYCMKNLER-KMRNMNIKDIVLANDWASHWRLTIDDLKGIDPTLIKRQSL EVEQSMTCYSTCCSMNLER-KMRNTNIKDIVLENDWASHWRLTVDHLHAIDPALSKKQSL NFSVKLKCYSSQCNKIIEHEFRKTTNIADLVLGSDWATHWQLTPEEINN-DTLDSKKQSF AQDLRLKCYSRFCNAVIEHEQLKNLDENEIYLAQDWVSYWKVT--DVKTLDKRVVTLQSH IDPRSLRCYSSKCNNIIAQELMRNTKLEDVVLELDWASHWKLTADDLRSLDKSTAKRQSL SPTLATVCYSETCLPTESRQELKLSEIINKSVGL-WTDYWKLTPEMLAEINPREIQRQSF G----YTCYSTKCSDTRKREDKKRTESTSSDQMD-WAQYWELTDDQLARIDPREIKRQYA IFDLIILEERSLSMANAAVEIYGKRF---DPDLLPDET--NFASLAFDIFLPIIEIHKEF IFDLIVLEERSLNLANAAVEIYGASF---DPALLPDDP--NFKSMAYDIFIPLIELHKDI IFDLIILEERSLNMATAAVEIYGKRF---DTALLPDEP--EFKSLAFDIFEPLIQLHTEF IFDLIILEERSLNMANAAIEIYGKRF---HPDLLPSEP--NFSELAFDVFVPLIELHKEY IFDLIILEERSLNMATAAVEIYGKRF---DKSLLPDEP--EFKALAFDIFEPLIQLHTEF ------------------------------------------------------------ IFDLIILEERSLNMATAAVEIYGKRF---DRSLLPDEP--EFKSLAFDIFEPLIQLHTEF IFDLIILEERSLNMATAAVEIYGKRF---DKSLLPDEP--EFKALAFDIFEPLIQLHTEF ------------------------------------------------------------ IFDLIVLEEKSLNLAHAAVEIYGAQF---SPALLPTDE--NFASLAFDIFYPLIDLHKEL IFDLIILEQRSLNLANAAIEIYGSNF---DPSFLPLDP--NFASMAFDVFIPLIELHKEY IFDLMRYEQTFIQRADCFVEVVAPEFIKAAKSYFGQNSLAKFEQDVISAGKQIVDIHRTV IFDLIMLEERSLNLAYAAVEIYGRKF---KQALLPRDP--NFKKLAFDIFEPMIELHKEY IFDLLKYEQTFIQRAKCFVNIVGPEFIKAAQILVGSHEINKFEDDVLKPGKELIQIHEKS IFDLMRYEQTFIQRADCFVEVVAPEFIKAAKSYFGQNSISRFEQDIISAGKQIVNIHRTV IFDLLRYEQTFIQRAQCFVEVVCPAFIKTAQTYTSNSKVKKFQSEVLPAARNILEIHQRK IFDLLRYEQTFIQRAKCFVEIVAPEFIKAARNYLGKNSINNFQQDVVSTGKQIVDIHQKT LFDLIKFEQTFIQRADCFVTTVGPEFLRVSQTMISQDVLRDFGEKLLKSAKDLVSIHKTN VLDLLRNEWGFSARARLFVEDFGPQFFARAKTDPKIKIPSNYQNEVIDSRSELLEIHKTM IFDLLRYEQTFILRGLCFVEIVAPEFLKATRVLLGANRVDKFHEEVIAPGWEVVRIHKEV IFDLIILEERSLNMANAALEVYGKNF---DPNLLPDEP--NFASLAFNVFPPLIQLHKEF MHELIVGEEHFIRDLEILHNVYGESL----KSHMPDKQ----FRDMF-AVQDIIQCSKEL ILKPLFWKIKTRGKFIDGIGKIYLKWCHEVRDAYLNYANAMATVHEVISWEKTHHTKFAE LLSPILWKLKIKGKFIDGVGKIYLKWANDAKQVYVKYAQNMATVHEIINWEKENNTRFAS LLTPIFWKLKTRGKFIDGIGKIYSKWCAEAKDIYLDYAKAMATVHEIITWEKKNKTKFVA LLSPIFWKIKTMGKFIDGIGKIYSKWCEQAHDIYLKYATAMATVHEIITWEKAHHTEFAK LLTPIFWKLKTRGKFIDGVGKIYSKWCGEAKNIYLNYAKAMATVHEIIMWEKKNKTKFVT ------------------------------------------------------------ LLTPIFWKLKTRGKFIDGIGKIYSKWCGEAKDIYLNYAKAMATVHEIIMWEKKNNTKFVS LLTPIFWKLKTRGKFIDGIGKIYSKWCGEAKNIYLNYAKAMATVHEIIMWEKKKKTRFVA ------------------------------------------------------------ LLTPIFGKLQTKGKFIDGVGKIYIKWCNEARATYLHYAESMAVVHEIISWEKQHETRFAA LLSPIFWKLKTRGKFIDGVGKIYLKWCSEAHNTYLQYADAMATVHEIISWEKEHNTKFGS LFEPLLKILIAEGKFIVGIGQTYSDWAFEVKPHLIKYMSCMPMIEELLGIETIKA----- LLTPIFWKLQSRGKFIDGVGKFYLQWCNAGRDLYLQYAEAMATVHEIIKWEKAHGTQFSQ LFEPLLRILISDGRFIVDIANIYYNWSKVVKNSLLKYMSTVPMIEDLLKNESMKR----- LFEPLLKILIAEGKFIVGIGQTYSDWAFEIKPPLIKYMSCMPMIEELLGIETIKA----- LFEPLLKILIAEGKFIIEIVNIYIDWAKEVRSHLMTYTNNMPMIEDLLSIAELKA----- LFEPLLKILVAEGKFIIGIGNAYSHWAYEIRSPLIKYMSCMPMIQELLNISTLKS----- LYEPLLKILISDGKFLAGIASLYYEWSKSVRSALLEYMSCVPMIEYLLGNEALKD----- VLDPLIEIYKSDGKFVDAIAKIYSKWTKKAEQAFMRYMSTVPLLYELLNVEFLKE----- LFQPLLRILVAEGRFIDEISAIYNEWAIAVKKSLLQYMSALPMIEDLMRYEPIKR----- LLTPIFWKLKTRGKFIDSIGKIYLKWVNEAREIYINYATAMATVHEIITWEKQHNTKFAQ LQGRLKARHII---FVTGIADIIIEWIKVARPHFLAYANRYLHADRRIRKEREDNVLFSQ WLLETDNLPEITRSKMYHFFGGYFKSLQNMPVTLSSILKNTSPSSEDYGALQLVIKEVTQ WLRQIDESTPITRSKLYHFFGGFFKSLQNMPVTLRSVLKCTDPSMDDHEYLRMAIQEIEQ WLKDIDNSIEITRSKMYHFFGGFFKSLQNMPVTLRSILKNTDPSMEDYEYLKIVIKDVDN WLNEIDNSPEISRSKMYYFFGGFFKSLQNMPLTLQSILKNTDPNVEDYLYLQKVIKDIER WLKEIDNSVEITRSKMYHFFGGFFKSLQNMPVTLRSILKNTDPSMEDYEYLKIVIKEVEK ------------------------------------------------------------ WLKEIDNSVEITRSKMYHFFGGFFKSLQNMPVTLRSILKNTDPSVEDYEYLKIVIRDVER WLKEIDNSVEITRSKMYHFFGGFFKSLQNMPVTLRSILKNTDPSMEDYEYLKIVIKDVEK ------------------------------------------------------------ WLKEIDESPEITRSKLYHFFGGFFKSLQNMPVTLRSILKCTDPSMDDYEYLNTAINEIEK WLKQIDNSPEVTRSKLYHFFGGFFKSLQNMPVTLQSILKNTDPSMEDYEYLKLAISEIEN FIDRISTLPRVRDLKVNVFISTFNSRYMQLPLQLEDIYKKFDVNDPEHISMLKAANDIRK WLRSVDDSPEISRSKMYHFFGGFFKALQNIPVTLSSILKCTDQSMEDFEYLKLAISEVES WVDEVRNIERVKELKVNGFLSTFNSRYQQLPLQLFDIRKLFDSQEPEYISLTKAIDGIKR YIDRISALPRVRDLKVNVFISTFNSRYMQLPLQLEDIYKKFDVNDPEHISMLKAANDIRK FVDKIGVLPRVRELKVNIFISTFNSRYQQIPLQLLDIRNKYQENEPEHFLLKQASDEIKG YVDQIGNLPRVKDLKVNVFISTFSSRFLQLPLQLHDIYKKIDENDPGYIAMHKAADEIKQ WDSTLRNNPKVKDLQVNGLMSTFNSRYQQLPLQLMDIRKFYDEQEEEYEVLTKAVDSIKS WVAKVHD-KRLLKLNADCFQSTFSSRAFKLPLELRGILDLL--GEEDKQSLAKAVEDVQN WVDEVRKLPRVQDLQVNGFISTFNSRYQQLPLQLSDIKSLYDEQDSEFIALTQAIESVKL WLAEVDNLPDITRSKMYHFFGGFFKSLQNLPLTLQSILKNTDPSMEDYEYLEIVIKEVES WLGDMSKDPRTLGKPYSIYFHRVIPRLARYSLLLGTISKHTTNEM-ELELLSRAVAECDD LSADVDKVHGMAIDRRKLIRFSKQLVYSMVKGDLSLGLADPKRVMINCDTVLKKSDHWLE LSRLVDKAHGDAIDKRKIVRLARQLIFSTTNNELDLKLGDGDRKLIMQGILQKKRELWLE LSFEVNKVHGLAIDHRKLVRFSKQLVLSDAIQDLALGLTYPERKLILSGTVYKKRELWLD LSSQVDKAHGDAIDHRNLIRFSEQLVVNDSDQDFDLRLYDPSRKLLISGLLLRKRDLWLD LNFEVNQVHGLAIDHRKLVRFSKQLVLSDAIQDLALGLTYPERKLVLSGTVYKKRDLWLD ------------------------------------------------------------ LNFEVNQVHGLAIDHRKLVRFSKQLVLSDAVQDLALGLTYPERKLVLSGTVYKKRELWLD LNFEVNRVHGLAIDHRKLVRFSKQLVLSGAIQDLALGLTYPERKLVLSGTVYKKRDLWLD ------------------------------------------------------------ LSTEVDTVHGMAVDQRKIVRFSRQILFSVIRQELNLKLTEKTRKLLREGVVYKKRELWLD LNSTVNQVHGIAVDHRRVIRFSRQLVIGLDRQELDLKLTEKSRKMVKSGTVFKKRDLWLE LGVRINDSKKSADNNYAISVIKDQLLWKSGVTQINLNLNSPNRKFVCRGDLTRKSVLSQT LNSLVDRTHGNAIDQRKVVRFSRQLIFSPSLQELDLRLNEKSRRLLKSGIVFKKRDLWLE LGSKVNEMKVHADNIHALKKIHKQLIWKNNVNHTNANLGSENRRFFHRGDLTRKGDLKIN LGVRINDSKKLADNNYAISVIKDQLLWKSGVTQINLNLNSPNRKFVCRGDLTRKSVLSQT LGSKINDSKRTADNVHAMEQIKAQLLWKSSVKQINLNLNSSNRKFICRGDLTRKSDLKLT LSARINDTKKSADNLYALNNIKNQLVWKSGLLQINLHLNSPNRRFVCRGDLTRRSDLKQT LGTTVNQMKVHADNVHSLDILQKHLTWKSNIFKPNINLTSTKRKFYYRGDLNKKGDLKIN LTSKIQKMKVSVENKNELRKLQ-EIKW-GNFNKERVNLKSTNRRFIKRGPLVRRGELKIN LGAKINDMKIHADNIHALKRLKVDLLWRKDVKQVNINLSSENRRLIRRGDIQRRGELKFS LSAEVDRVHGAAIDRRKLVRFSKQLVFNTSSQDLDLGLTDTGRKLLMAGTIMKKRELWLE VTRQCNMVIGNVEKQVELLDLKSQFVFKPDCG-ADLKLESTQRKIMRRGDVQRKSDYGFE PYPVFLALLDNFLLITELVSKGLEKK--YKLIDRPIPIEYLNLEIKRAPEEFNKDPLG-- SAPVYVFLLDNYFLITEEIFKGSGKK--YKLIERPIPIDYLSVETKEDINYKRKSSDADE PTPVYIALLDNCLLITEEINKGESQR--YKLIERPIPIDYLSLEKRRIAEANTVPRSYSQ PSPIYLVLLDNYLLITERIIGNDKKTIRYKLIERPIPMDYLSLEKRTPNEDSS------- PTPVYIALLDNCLLITEEISKGETQK--YKLIERPIPIDYLSLEKRKIPGTSKQPRNYSQ ------------------------------------------------------------ PTPVYIALLDNCLLITEEITKGEAQR--YKLIERPIPIDYLSLEKRRIPETNKPSVNDSQ PTPVYIALLDNCLLITEEISKGESQK--YKLIERPIPIDYLSLEKRRIPETNKQPRNYSQ ------------------------------------------------------------ PVPVYIVLLDNYFLITEIVTKGNEKK--YKLTERPIPLDYLSLERKEDLKANSAEEVTLM ATSVHIVLLDNYFLITEAVVRGSDRK--YKLSERPIPIDYLSLETKEGLKISQIMTNSSD ANINHIILLDNYVLITDRARNRRGGLA-YKILEDPIPVEYLIVEEK-------------- NTQVYLTLLDNYLLISEVISKNNETK--YKLSERPIPIDYLSLEAKEDCSLPSLKSETRQ SFTNHLILLDNFLFITERVKNPKMSLFSYKVVENPIAVELLLFEIKEKESTT-------- SNINHIILLDNYVLLTDRARNRRGGLA-YKILEDPIPVEYLIVEEK-------------- TQINHLVILDNYLLITERVKNPKISGILYKICEDPIPIDFLMFSQK-------------- SNLDHIILLDNYMLITNRSRNKYGDPV-YKIVEDPIPIEYLIVEEKNASSGTSPN----- TNTVHVIVLDNYLLITERSKSQRTIR--YKVTETPILMDFLIVENRDKE----------- TYNNHVILLDNYFIITERSRNRAINE--YIVEKNPIPVELLLVEERESSS---------- TSTSHLILLDNYLFVTERSNSKAGIK--YKISDSPIPIELLLFETKEKD----------- PTPVYIALLDNYFLITERVMKGNQER--YKLIERPIPIEYLNLEQRKPSNEDGRSAGGSI WIDAHLVLLDNFLVLCKHQTGQHGPK--LYVTKKPIPLELLCVEQIDEAEQQTKGIHNIT -----DSRPTSQIVSDLDNKSSLNSRSSVVGDLNYGHTGISNNLPSSTEFAFKVRNTATN ESCNV---QTPSTSKKPPLLPAGTTMSSIPKTIYQTNATLNNDDNEESSYSFKIRNTASN KEHKSHTFSTPISSMRPLLRSSGNHVSTVYGDKKTSSTEISNANPNIDEFSFKIRNTATG --------------TTSLIKPLTSPLRKSARIINQQSNESIETRINSLECSFKIRNIATN KEHKSHNFSTPINSMRPLLKSSGNHMSTAYGDRKTSNTEISNANPNTDEFSFKIRNTATG ------------------------------------------------------------ REHRSHNFSTPISSMRPLLRTSGNHTSTGYVDKRTSNTEISNANPNTDKFSFKIRNTATG REHKSHNFSTPISSMRPLLKSSGNHMSTTYGDRKTSNTEISNANPNTDEFSFKIRNTATG ------------------------------------------------------------ NVNSN--NIDGLTAKSPSPNQLADPSNVPRHVYRTNASTMALDVPDDLIYSFKVRNTATN GVSQTTPISSVKPHLINAASTVTSIPKTLYYSAANTSSDDDSSDPNDATFPFKIRNTATN ------------VVSTSTLLSNQNSLGTT------QSGTADAENDDSDAFQLKLRYAGRK QEHDSTPVKSNRRRSLHTKAFSPHHPKSPYSHIPVIQGKGDAADSQEIQISFKVRNTATN --------------STLELKPITKSLTTLSNPASPVHQEFLDGEVEPASYPFKLRFAGRH ------------VVSSSTLLPNQNALTTT------QLGVADAETDDNDAFQLKLRYAGRR -------------------------------------------VAGSTVYPIKLASTSS- ---------AGLTSTVSPMSPNRSPIPPSNGKMTA----NEEDEDDADAFQIKIRYAGRK ---------GGITAKVGTST---------------STSKNGDGDEDVFTYPFKVRYAGRH ---------KTISHSPVTSGPSQN------------------QEEEPSNYQFKVRYAGRR ------------IDKSRRNSPVQNTLQ--------GTSPTNEAEEDASTYAFKVRFAGRY RESIYSAVRPHLINAASTVSKSLYSSPTHGTNKENSHTEISNAIPSHSEFGFKVRNLATN ---------SHVREVRDKRMSFIGGDHHSSSSSNPGAVTVLNEDSDQTTYPFRIRHLGQN DSYTFYVPNSIEWNNWMNAFKCCFKNRNND---DNRHPINLSIITAE-FSYQDRNAPVNL ESHTFSTSTMEEREHWVASLVKAFQNHMGH---NEKQAFQLQCLCDL-FSYDEIQAPTNL ESFKFYTTTAEELGQWVGAIMESFKKNAEK---HELNAFEFTVLSSE-FGYFDKDAPVNL ESFTFITESQDERQRWVNTIINTLKSTSSL---RVNDAIKLEVLSDN-FAYNDKDIPSNL ESFKFFTESAEVLNQWIDAIMESFKRNAEN---HDLNAFEFTVLSSE-FAYFDKDAPVNL ------------------------------------------------------------ ESFKFFTGSVEVLNQWTDAIMESFKRNADN---HDLNAFEFTVLSSE-FEYFDKDAPVNL ESFKFFTGSVEVLNQWIDAIMESFKRNAEN---HDLNAFEFTVLSSE-FAYFDKDAPVNL ------------------------------------------------------------ DSFTFHTFTVEERDAWISAIVESFRIHTET---NDQRVFKLHVLSDL-FKYDERQAPTNL ESFTFLTTSLEDRDTWVAAIIACFKQYSNK---NDRQIFKLKCLSDM-FSYDERQAPTNL RAYTFSCGTEREIRDWVNYFIAAKSTLCKRL--AHSNPYRVVSVSNTVFGYENSHARYDP ESFTFSTNSIEERDSWVASLVSCFKIHQAN---NNHRVFTLTCLADM-FSYEEGQAPINL NAFTFSTKTERERKDWINHFSMAKTNLCRRL--RKTEPYKLKTVANTCFAYEISNAPYDP RAYTFSCGTEREIRDWINYFIAAKSALCKRL--AQSNPYRVVLVSNTVFGYENSHARYDP --------------------------------------FR-------------------- RAYTFSCKSERERNGWESYFLATKENLGKRL--QASNPFRVEPVSNTVFGYEYNNAPFDP ESHTFLAGSEAERNRWISVLEKSRYNLMKRV--SPLAPYDLDLVDNCYFAYEHQPPPNDP FAFTFITKSEKDRADWIRDIKYARTALCSRL--RRTEPYSLNLISNTCFGYEQIDAEQDP STFTFIARSEAERMLWINSFTEAKSNLCRRL--SQSAPFELIPVDISSFSYDSAKAPADP ESFTFYSSSFEEREQWRKAFIACFDICKK----QTVTPFNVQVISTQ-FAYSEKDAPVNL ITYTLFCPSSLDRDRWHTAMVEAKRQYSSKVYAKNAEPFRLTVLSYLDFGYE---IPVRL PVAPEGSEIDSALKTYKRYLKDEFEN---IATTVFCSTEFDNEDTKFNLIATNSGVFLRK PLEPEGSAVSSAMKEF--YSVNSPKTFASMKGDILCSVSFQYENETFLLCSVNHGVYIT- PVAPEGSEIDVALKRY-AQKVDQDPFSWSKTTRIMCCEDVKFEGKVYLLVATIDGVFIKR SVVPEGSEIDMALKA-----HRPTSNSTLIRTTVLCSLEFKFEGKCFLLVSTSDGVFLSN PVAPEGSEIDVALKAY-AQKANKDSCSWSKTTRILCCEDVKFEGRIYLFVATTDGIYVKR ------------------------------------------------------------ PVAPEGSEIDVALKVY-AEKVNQDLCSWSKTTRILCCEDVKFEGKVYLLVATTNGVFVKR PVAPEGSEIDVALKAY-AEKVDQDSCSWSKTTRILCCEDVKFEGRIYLFVATTDGVHVKR ------------------------------------------------------------ LVAPEGSVIDVALKDY--KKTQREKKTPVA-ADINCSGKFVYESKTFVICGSNHGIYMTI PVTPEGSVLGMALKQ---FYQDNAGSKITVNADVYCAVQFTYESKRFILCGTNYGIYIAS IYDICQDSVEKTKKLNSDLYNPRLSRNRIVFSKLQCMCWFEYKGSKYNLVALEAGLYMC- PVAHEGSAIDCALKT---YYSNTPPSKVDVSADVRCAVHMQHEGRIFTLCATSYSIFMAS IEEASTDALSKLTELGGEIYAFNNARKHIVFSKAQSITSFEYSNTSFYLVGLATGVYCC- IYDICQDSVEKTKKLNSDLYNPRLAHNRIVFSKLQCMCWFEYKGCKYNLVALEAGLYMC- ------TPIQQQLQQQ----QQQQQQHHSCINCINCINRNNNNNNNNC------------ IYNVCEDSVNKMKKLKYDIYNPQLSRNRIVFSKIQCMSTFEYDYLKYSLVALETGLYMC- IQMLAESTNAVLKARRRDVFSPNVPKNMIERRKIKCAETCTFSRSTFVFVGTNQGVFCT- VYDLSVDTMKKLNFLSSDIYSLAGS---VVFSKVLSMCSFEFMGSQFVLIGLASGLYCS- LYDMSQKSLSLISGQG-------QEVGFGVSGQIQCYTSFQLGKSSFKLAGLSTGLYYA- PVTTEGSEIDIALKKYETENNRALQNVRIMPAMISCSISIEYEAKTYFFVATEFGIFMRE AVPNNASTLQRAIEKAGKLKTQPSSTSMTTRSKVNCATSFMFDSREFVFVGTDYGVFVSE NDYTTKFVKVLQNISVSRLQAVPKLGLLFVLDGQKLCYFSISSILAVYYNPERFLNANFV --LPRLWKRILNFSKVTKMEISTKLGLLFLLADRKLCYFNIPSLISAFYDSEQYLPDNRI DDYNHGFVKILETNDVKRMEASIKLGLLFVLDSKKLCYFSISSLLSTYIKGDS-ADKSCI KQCKMRFVKVLQCNEIRKMEMNLKMGLLFVLDDKKLCCYNLPSLLGAYYDPSEYLIDNCI DDYGSGFVKILELNDVKRMEANVKLGLLFVLDNRKLCYFNISTVVSRYLAQGNTLDENCI ------------------------------------------------------------ DDYSNGFVKILELNDVKRMEANVKLGLLFVLDNRKLCYFNISIVVSHYLLQKNSVDENFT DDYSNGFVKILELNDVKRMEANVKLGLLFVLDNRKLCYFSISTVVSRCLAQKTPADEKFI ------------------------------------------------------------ ADNPTGWKLVLHVLKVVQVEVSLKLNLLFALSDKRLCYFSLPSLICAYYDPVQYLPNNQV FDYICGWKRILNMTKVSRMEVNTKLGLLFVLADRRLCHFNLPSIICGYYDSQKYLDGNQI --ESKGWKKIIGGDNYVQMQVDSEIGIVVVLTEKQLGYYPIHQILNVYN-------ETKS ADSPNSWKRILTLNKTTRLQVNNRLGLLFVLTDRKLCYFNIPSIICTYYGIDEYLPEKQI --DMQNWKKVVGGTDITKIKVITSINLLIVLGGRHLRCYSLDLVVGVYY-------DKKE --EAKGWKKIIGGDNYVQMQVDSQIGIVVVLTEKQLGYYPIHQILNVYN-------ETKV --CNRK----------------------LMLNLMKTIQFSMQFVCNMLGSP--------- --CAQGWKKILGGADYIQTYVDSDIGIVIVLSDKYLRYYPIRQVINVYK-------EVKS --DRNNWKQILNTSNVTKLTVVPHLNVVLVLGNKVLRHYPLQSLVEVYY-------ERKE --DLQNWRKVANGANFVSLATDTSMSLLLVLAGNRLLYYALDLIVDVYY-------ERRK --DNGNWKRII-YEDVTAISCIPELRIVILMANKMLKYYTMDSILSVYY-------ESSN SESSKKFVKVINCVYVKKMESNVKLGLIFVLDNRKLCYYNIPSLLGAYYSPQKYLSNNRV LSRHKGYKRCVDLHKVTQIGVIETLNLVIILCHRGLIYYHLDQLLNRSM----TKDAATP VGIVLKDKVSFFKFADD-NSKQLFYERKGK----IVVSTPEFHSIMN---------NFNC VGIIIQEKITFFKMAED-NSRHLFYERKGE----IIIMTPEFDPLTK---------VFKF VGIVIKDKVRFFKLADD-NSKHLFFERKGK----IVILTPEFDQLTN---------KVKY VGIVIRDKVGSFKFADD-NSKHLFYERKGK----IIVVTPEFDQITK---------SLKY VGTVIRDKVRFFKIADD-NSKHLFFERKGK----IVILTPEFDQLTN---------QVKY ------------------------------------------------------------ VGTVIRDKVRFFKLADD-NSKHLFFERKGR----IVILTPEYDQLTN---------KVKY AGIVIRDKVRFFKIADD-NSKHLFFERKGK----IVILTPEFDQLTN---------KVKY ------------------------------------------------------------ VGVILQDKVTYFTMAED-NSRQLFFERKGK----IVVLTPELDAITA---------AFKL VGVMIREKVTFFKMAED-NSRHLFYERKGK----IFVMTPEFDRITK---------AFKF NLTCIKDTVLFFEMGRHKNVKMLFYAKKKTGSIHFKVMIPQIDNGGI----------FSR TGIVLQEKVGYFKMTDD-NSRQLFYERKGK----ITVLTPEFDRLTK---------RFKY HISSINEHVLFFAVGKHREINMLFYAKKKSGTTNFKVLIPETDNDGM----------FSA NLTCIKDTVLFFEMGRHKNVKMLFYAKKKTGSIHFKVMIPQIDNGGI----------FSR ------------------NIHLHFHVK------------PNVKRMTG------------- DLTGIKDHVLFFKMGRHKNVNMLFYAKKKTGSIHFKVVIPQLDNSGI----------FSR RLSSFNEEILFYEVGRHNEIPTLFVARKAAGEVRFKVFIFDTDANGI----------LTS HLTSVASKASFFEIGKHRAMTMIFVAKANSSGTDFTVFIPETDNGGV----------FST KLPCINDTVQFFEVGKHRGMIMVFYAKKKTSSTNFKAVIPEIDNDGV----------FTG IGILVKDKISTFKFAED-NSKHLLYERKGK----IVVLTPEFDRLTK---------SLKF MGYKLSSSASFFTIGNMKNRTLVFYKSREGLNSVFKVLEPIRQKGSQKRSRMSLSRSTEY FKIYKKYYLPSSISDIVIFKKSFMVFTKKNVFLFNDAFNEGASLPFYNDKEMIAVTDVKK FKHYKSYKIPVTVSDITILRNSFIVCSSKGAILYSDSFNEGAFLPTLTDTSKLKAEYVKS FKFYKEYKLPSEIEDITILRKSFAVCTKKTVILYQDSFEDGIVLPFLNDKEMMATEEAKK FKEYKQYRLPVEVKDIVIFKKSFMVCSSRGVFLFQADFNDGNLLPFIANDGAFEAELVKN FKFYKEYKLPSEIEDIAIFRKSFAVCTKKTVILYQDSFEDGIVLPFLNDKDMMATEEAKK ------------------------------------------------------------ FKFYKEYKLPSEIEDIAIFRKSFAVCTKKTVILYQDSFEDGIILPFLNDKEMITTEEAKK FKFYKEYKLPSEIEDIAIFRKSFAVCTKKTVILYQDSFEDGIVLPFLNDKEMMATEEAKK ------------------------------------------------------------ FKPYKRYKLPLEVYGIVVFRTSFIVCTSKGAILYNDTFNDGITLPLLNDPDLVQAEYVKF FKVYKEYKLPSEVQDIAVFKRSFIVSSSKGALLYNESFNDGIVLPSFLNDKPVLAEYVKT FKDHARFYIEAECFGISIFNSSFAVHTDKGFEILTLDKLIPSSVPELPPPVETEVETIRM FKYYKEYRMPGEVKDIAVFAKSFVVCSSKGALLFNESFNDGISLPFFNDKSMASAEYVKT FKVIKKFYVQAECYGISIFNTSFAVHTNKGFEVLELDKLLPRSIPDFPH-SESSIELVKK FKDHARFYIEAECFGISIFNSSFAVHTDKGFEILTLDKLIPSSVPELPPPVETEVETIRM ------------------------------------------------------------ FKDHARFYIEAECYGISIFNSSFAVHTNKGFEILELDKLIPSSVPELPPPSDADVDTIRK FSLIKEFYIAGQCYGLSIFNTSIAVHTERGFEVMKLSTLSPRTIPDLP---ESG-DVIRR FKEYKKFHVAAACYGVSLFNSSFAVHTNRGIEILNLSTLLPRSVPEFSNTESLSIEAIRL FKVFKRFYVQAECFGLSIFNTSLAVHTNKGFEVLELDKLHPRSVPDIPGTDARKMEVIRK FKFYKEYSLPNDVHDIIVFKKCFIACTTKGSIVYQDAFNDGIVLPFFNDTDMSSAEYVKK FRDAERFYVPSECWGISVFKNYFSVHCTKGFEAMSLDFKVPRTLPIISSG----STDLRK DIGKTKPITAFRLQSGDFLMVYDEAIVKINSSGMIPNWLILDF--YCTGASYHNGYLFLI DIKKTKPIACFRIDPNNFIICYDEAIIRINKFGEIPDWLVLDF--YCIGVSLNLGHLILA DICKAIPVSFFQISQSKFLLVYDEAVVKINCYGEMSDWLLLDF--CCTGASFHENHLILV DINKTKPITCLQLGDPRYLMIYDEAIVRMNAYGQVVDWLVLDF--YCANATFHMGYLILI DICKAIPVNFFQISQSSFALVYDEAVVKINCYGEMSDWLLLDF--CCTGASFHGNHLILV ------------------------------------------------------------ DICKAVPVNLFQISQSKFALVYDEAVVKINCYGEMADWLLLDF--CCTGASFHGNHLILV DICKAIPVNFFQISQSRFALVYDEAVVKINCYGEMSDWLLLDF--CCTGASFHGNHLILV ------------------------------------------------------------ DINKTRPVTCFQLSPNDFILVYDEAVIRMNKYGEIANWLVLDF--YCTAACMTSEFLILT DINKTKPVGCFQISNDDFILVYDEAVVKLNNNGEIPDWLVLDF--YCLSASMNNEFLILV LIAKYKPMGMYKLNNNKFLLVYKEYAIFINKHGKPSRDFIIHF--KAHHVYFENNYLFVV DIRKTTCVACFQLSDDDFVIIYDEAVLRINRNGEIPDWLVLDF--YCSAASFTEEFLILF AVTSIKPMGMFKLNNNTFLLVYNDCAIFTNKHGKLSRYLKFEF--KAKTIAFINNHLFLV -LAKYKPMGMYKLNNNKFLLVYKEYAIFINKHGKPSRDFIIHF--RAHHVYFENNYLFVV ------------------------------------------------------------ LLANYKPMGMFKLSNNKFFLVYREYAIFINKHGKLSRDSIIHF--KAQSVYFDNNYLFVV AISHCSPMGMFKLNNNKFLLVYKDLAIFVNKAGSLSRTVRFDF--RPTSISFVDNNLFLV AVTGIKPMGMFKISDLHFLLVYSNFAIFIDPLGKLSRSSIFEF--QAKSIAFVKNSLFLV HVSSAKPMGMFKLNNNSFLLVYNDGAVFTNKHGKISRPLHFDF--KAQSVMFFDNNLFLI DINKTKPISCFHLDDSLYVMVYDEAAVMINKYGDIENWLVLDF--YCTGVSLIMGYLILV RLEGLRPLAMFQISDSKFMLCYDELLVYTDHFGNLASKMI-----KAKAVALQHPYLVIV GENLILVYQLSYSELVQIINSKKIELLNSGG---MDYPTVTSSHPKIPNRQLLFSCIPAN GDNLVQVYNLRFNTIVQIIKGKKIKITDTS----QDCTSIVLTHPNIAGRQLLLHFNLSV GDNLIQIYDLKNGELIQIIKGKKIKLASSET---KEKTILVLSHPNILNRQLLVACNPVT GENLLQVYNLNSCDAIQIIKGKRIKLMSMSE---NDDPVVILSHPNIANKQLLLKCKIGK GDNLIQIYDLKNGELVQIIKGKKIKLASSER---REKTILVLSHPNILNRQLLVACNPVA ------------------------------------------------------------ GDNLIQIYDLKNGDLVQIIKGKKIKLAGSER---REKTILVLSHPNILNRQLLVACNPVT GDNLIQIYDLKNGELIQIIKGKKIKLASSER---REKTILALSHPNILNRQLLVACNPVT ------------------------------------------------------------ GENLVQIYDFNYSRLVQIIKGKKIRLLNASK---TPDPVIALSHPSYPGRQLLLAFSLTR GENLIQIYDFNYNRLVQIIKGKKLELISCQK---QDDTVVVLSHPTIPGRQLIVGFYPAE NDQLIEVWHIGDPKKAQVIIGKDIKHLGQNG--------FSMANPLVPGLQLVFRLVE-- GENLVQIYDLNYSKLVQIIKGKKIKLLHPEY---TENPIMILSHPSIPGRQLVLEFKPSS CDEVMEIWSISDNRLIQVVTGKDMNMLSN-----EDTICFSMANPKVPGLQLLFELQPKE NDQLIEVWHIGDPKKAQVIIGKDIKHLGQ-----NG---FSMANPLVPGLQLVFRLVE-- ------------------------------------------------------------ NDSLIEIWQIGDPKIAQVIVGKDIKHLGDNG--------FTMANPLVPGLQLVIRLASEK CEEVIEVWSISDNTLIQVIPSKGIRMINS-----DR-LMFSTTNPQNQGLQMVFQMLPRK CDEVIEIWRISENGLIQVITGKGIQMIN------SDKLAFSMANPMVPGMQLVFELRKKS TSEVVEVWSISDNRLIQVVTGKDVRLVGK-----DPYCVCAVANPLVPGMQLMFELEPKE GDNLVQIYDLNTGRLVQIIKGKKIRLISSKN---IDEAIISLSHPNIANRQLLLACKPRD DDEMAEIRHID-GTLKQVIPGQDMRLLDDH----EGQIKLCMANPNIYGRQLIVELNTNE YQVKSLSLAKSVLTMDVHLSYFRDEYNFEEALRLLPFEWQCRVIQKRAHKDKVTALCNRL -----MPGDKHIFICDFEDGYLKDSFNFEMAMRLLPFEAQDKVLRKRSDKLQRMALTNRL VLDRLISKVENVLAVKIQEDLLVDDFTFEVLTRVLPLDAQAQIFSRKSFHDRCTILCNRL ------------------------------------------------------------ MADHVVSKVAGIFVVEIQEDILADEFTFEALMRTLPLASQARILNKKSFHDRCSNLCSQL ----LVPKVIDTFVVEIQDDVLADDFTFEALMRALPLDWQAKILNKKSFHDRCASLCNQL MVDHLVSKAAGVFVVEVKEDVLADEFTFEALMRALPLDSQARILNKKSFHDRCSSLCSQL MADHLVSKVADVFVVEIREDVLADEFTFEALMRALPLASQARILNKKSFHDRCASLCSQL ------------------------------------------------------------ ----TACAFCGVLSTSAADGYLDDEAQFETALRLLPAADQAAVRSXR--AGRAVVLASRL ----INKDLRVILVVDSKDNYLLDDFHFETAMRLLPLHTQSKILGKRPEI-RKVSLCNQL ----MQDHLNDLFTTRLTNEFWNDDYNFECSLRLLNLSLQQKISSITPNHQKYKQLLSNL PSEQPDCDLACVLVCDSRSGLLNDDYEFEMIMRYLPLETQQKILCKRKGETQNVALCNQI VLI-EVVASRDFTTNTSTTAYLNDDFNFEMSLRLLNLKDQLAVRCQKNASSRYKQLINRL ----MQDHLNDLFTTRLTKEFWNDDYNFECCLRLLNLSLQLKISSSTTNKQRFKQLLSNL ----LTQKLGSTLFVTDLSEFLQDDYNFETSLRLLNIKLQTHIQSLNPVKFRIKQLVSHL ----SISQHSHLFTTRLSSNFWSDDYNFECSLRLLNLKLQQKISEMRLHHQKYKALLTSL QKL-EGISLEEIFTTQIDTKFLNDDYCFEVCIRNLSLHDQLKVRNAK--TDRVKRLVSFL SM--DLETINDVFTTTITEEFLSDEYNFEVTLRLVDLPLQLKIQAVKDRFQRIKLLIGEL TFIGSQHDTKAVFWTSVTPKYLSDDYNLEDVLRIFTLSERVKLRKQ-PIHNLAKQLLSKL L---ISVEQLLVILIDTSDDFLKDDFEFEQALRLLPMAWQLGVINKKNLKSKYISLCNRI LIVD---------------------------MRLLPVESQLDISRFRYRSDAKMALGSQL LQLYGCRLE--LNTQAIDFTQGKYGKPFVKESFNFSMTNGENFVSIIMANLQTEVGIDLA LQLYGCSIVTGENFNHLIFGNGPFGKPMLLNGIEFSMSNGEQSCVMAVQ--ETEVGIDIA LQLFGCSIVTGLDYQELRFDRGGFGKPFLGRSIPFSMTTGEQCVAMSLVKCYQNIGIDIA ------------------------------------------------------------ LQLFGCSIVTGLNFQELKFDKGSFGKPFLDRFLPFSMTIGEQYVAMFLVKCYQDVGIDIA LQLFGCSIMTGSDFRELKFDRGSFGKPFLDNSLPFSMSTGEQCVAMSLVKCCQKIGIDIA LQLFGCSLATGLNFREVEFETGSFGKPFLAHSLPFSMSTGEQCVAMSLVKCYQDIGIDIA LQLFGCSIVAGLNFRELKFDKGSFGKPFLDRSIPFSMTTGEQYVAMSLVKCYQDIGIDIA ------------------------------------------------------------ LRTLGCAVHTGCAPALLAFDYSRAGKPYLRPAPAFSVSRSDCIAVIYVRE-GGAVGADLA LQLFGCAFLTGKKPSAIEFVVGTHGKPRIKGSVAYSMSNSDGITVMYLKRSTTSVGVDLA FIRYAINSIIQDLFKKIEFDYNEFGKPILPYNFQFNISSSNDIIALIVEFPYDPIGIDLS LQRLGASKITGMGWNELEFASGPHGKPGIKENCTFNLSNCDGRTAMYIKSTQQEVGIDLA FAKLILNYVLYQPWKDLEFSYNQFGKPYLTYHFQFNMSSSNDIIGIVVELNLGPIGIDLS FIRYIFNSILFNLFNKIEFDYNEYGKPILSSNFQFNISNSNDIIALVIEFSIDPIGIDLS FTRHVLNKVLKLNFLQVQFAYNEYGKPLIN-NLEFNSSSSNDIIALVVCN-GSAIGIDLS FTRYVINQLLGNFFDVVNFSYNEYGKPMLP-DFQFNSSSSNDIICMVVEYSSHPIGVDLS FTKLVLNYCIYDPWGTLEFEYNEFGKPSLKTRFVFNSSSSNNMMAIAVQFDATAIGVDLS FQRLILNFHLGDPWRRVQFQYNKYGKPLLPAKFQFNSSSSNSIISIVVEHSNSPVGVDLS LVKVVINYFRGAPVQDVPFKYEKYGKPFLDTNVQLSISTSNEIVCIAIEKGGTPIGVDLS LQIFGCAILSPKDFKSLSFTTNEYGKPETP-GIAFNMSNGDRLVGMFAIRYNQLVGIDIA LQRYIATVLTGKKWTDIVISKTPQGKSFVAP-FDYNISHHSELVVVAVRPDGKQIGVDIT SINDFTSEGDLKIYEDVLSTEEYEKINNKRLFAFYWSVKECYTKYLGVGLNGDLKIINV- STCNHWDAEYLDTFQDIFTDQEFKTLKEDELFTLYWSMKESYMKLIGTGLNTNIKAIDIG STCNYGGKEELELFKEIFSDEEFKGLQRCVIFTYLWSLKESYTKFTGTGLNTNLAMIDFG ------------------------------------------------------------ SPCNYGGREELELFKEVFSEREFNGLLKCTIFTYLWSLKESYTKFTGTGLNTDLSLIDFG STSNYGGKEELELFREIFSEEEFRALLRRVVFTYLWSLKESYTKFTGTGLNTNLAEIDFG SVCNYSGREELELFKEVFSEGEFKALLSCTVFTYLWSLKESYTKFTGTGLNTDLSLIDFG SPRNYGGKEELELFKEVFSEREFKALVKCIAFTYLWSLKESYTKYTGTGLNTDLSLIDFG ------------------------------------------------------------ SVCLSWAPDEILQLHDVFSAAELGRLRAAELFAYYWSLKEAYGKFRGTGLAGDLRLADMG TTCEQWETDYLHMFKDIFSAQEYLYLQDDSTFTHYWSLKEAYTKYTGTGLNCDLSSVDFK HSNSISNTEYLEQFKPIFDDYELPQIDNYFKFNHFWTLKESFTKLIGSGLNIELSDFYFI SICENWGPNYLELFRDLFSSEEFHNLKNDRLFTHYWSLKEAYTKYSGTGLNCDLAAIQIG HSQAISPTNFLEEFKPIFDPAEIEQLLEYIIFNQLWTLKEAFTKFLGSGLNIDLSKFCF- HSKNISNTKYLEQFKPIFDDYELPQINNYFKFNHFWTLKESFTKFIGSGLNIELSDFYFI HLQNISSERYLDEFKPIFSEHEVEQVNSYFKFNHFWTLKESFTKLLGCGLNIDLADFYFK HSQKVSPVNYLEEFRPIFDKHEISQVDTYFKFNHFWTLKEAFTKLIGSGLNIELSDFYFE HEESISPVRFMEQFEGIFSQRERECLLSYIAFNQLWTLKEAFTKYVGCGLNVDLSTFSFH HSQRISPSLFLEDFEPIFAPSELEYLRAYFVFNHLWTLKEAYTKLLGSGLNIELSDFFFK HSDSISPINFMSQFDPMFSESERTQLMDYIAFNQLWTLKEAFTKLIGSGLNLNLASFGFD STYHIGD---EELFHTIFCPDELE-LLKSKSFAHLWSFKECYIKYIGKGLHYDLSELNFS STPSNWTMNWMEGFSQIFSPFEYSQVTSNGEFFLRWALKESYSKAIGMGLNMDLAKLEFR --FSAPLINSTFKLKDIT-FHSRWVDNEILTYCFPAQ------DFLKPIHLNVVSVIEGI EIEPLQELEVEKKINGRHIFISRWIKHEIVTTSLPQTFDSYNADTKQLIE-YLSLRQDDH AIFPVNGASLNITLDKVPLFHSQWFNNEIITTCIPRSSNDLDMGIPKLYNVPLSMLIDYF ------------------------------------------------------------ AIFPAEGASMCITLDEVPLFHSQWFNNEIVTICMPKSSDKINTNRPKLYNISLSTLIDYF SIFPANGTSLNITLEKLPLFHSQWFNNEIITTCIPRSSNNINMDTSELYNISLSTLIEFF NTFPVKGASTYKTFDGVSLFHSQWFNNEIITTCMPRSSDNIRTGRPKLYTISLSTLLDYF AIFPAEGACMCITLNEVPLFYSRWFNKEIVTICMPRSSDNVNTSKPKLYNIAFSTLIDYF ------------------------------------------------------------ ELDPLRRGELRRTLQGKHVLSSRWHAGHVLSLCEP-STEEICLPMEEVVRLCRPSLGMEK NVDPLERSKVLTHNNSETHFLSSWLDKQILTICDGPSSNNQTLIDVPTVNLHIKIIVQYL VDFSSDNEKFQTSIVGNNIYSLNWFDKLELAKNTALNKKEFYCKSIQPIELRFEKLLSEH AIEPLEFGQIVCNIGNKSVFRSKWLATTVMSICETESTGHEE-SELTIFELSVEDLVSYL --FLNKSMVIIATYDNELLFEVDWKCKLSDEKNLQLSSHHFNCKHTVSNNVDFFRVLSDI VDNDEFSNNFQIKKRNITIYSLNWFDKLG-QKNNNLNKKKIYCKSIKPIELRFDKILSEY VGNEDEYARYCVHQQERSQFELKWFDKLFIDKCS--NRNEFYCKSIKCFDINMTALLQRN VGFSEEDYEYIQTQDTSDCYSLSWFEKLKAKKDGNLEKEEFYCKPIKPIEVQFDKILLGY A--PLGMLSMQNSTEGNGFYDIDWQSNLPKIYAQAIGRELACCNPSTNVHLNFSSILRGI FGFNVENYYQLKEENGISEYNVEWYEGLIAKKDHSLENSESYCSKLRSFEVSFLDILKQI MNDSS--------------ADLKW-NTTGLSDSQKLPIQKFKCVPPEVLYLDIGEILFN- NH-----INSNISIDNNPLFHSKWSNQEVITICPPLTN-----NPPNFYILNIKDIISQM NLRLMDAAKGTDVVGAVAVAQDRWHNNHVIALAEGVNVEQVRLTVEELMSLPFGPAVAMQ KRKAVLLNSLTRGRVRTSFNKYNLFNLYKKGNIDFRSKSLYQQKWSAKQETRAYHGEHIT PRKAVLLNSLSRGKVRTSFNKYNLFNLYKKSQVSFRSKTLYQQKWTSKQETRAYHGEHLT IRKANLLKSLARGRVRTSFNKYNLFNLYKKGSVDLKSKSLYQQKWTAKQETRAYHGEHLT -RKATLLNSLSRGRIRTSYNKYNFFNLYKKSKVDFKSKTLFQQKWTAKQETRAYHGEHIT IRKANLLKSLARGRVRTSFNKYNLFNLYKKGGVDLKSKSLYQQKWTAKQETRAYHGEHLT IRKATLLKSLARGRVRTSFNKYNLFNLYKKGGVDLRSKSLYQQKWTAKQETRAYHGEHLT IRKANLLKSLARGRVRTSFNKYNLFNLYKKGAVDLKSKSLYQQKWTAKQETRAYHGEHLT IRKANLLKSLARGRVRTSFNKYNLFNLYKKGGVDLKSKSLYQQKWTAKQETRAYHGEHLT ------------------------------------------------------------ CRKALLLKSLSRGKVRASFNKYNLFNLYKKSQIDLRTKTLYQQKWSSKQETRAYHGEHLT S----------------------------------------------------------- LRRIDKVSSMTKGHITMSMNKLNLFNIYRKDPLQYFGKTLYQQKWAAKTETRNYHGQQIK NRKAVLLKSLARGRIRSSFNKYNLFNLYKKGEVDFRSKTLYQQKWTAKQETRAYHGEHLT -RRTQQMNSMSRGRVRASMNKFNLFNLYKKPTISYHGKTIYQQKWTAKAETRAYHGEHLT LRRIDKVSSMTKGHITMSMNKLNLFNIYRKDPLQYFGKTLYQQKWAAKTETRNYHGQQIK VRRWNKMSRMIRGKVEMSMSKLNLFNLYRKDPIDYVGKTMYQQKWTAKSETRAYHGEHLK FRKVDKLRHMTRGNITMSMNKLNLFNVYRKDPLSYFGKTLYQQKWAAKSETRKYHGEHLR VRKATNLYSTARGRVRASMNKYNLFNLYKKPQIRYQGKSLFQQKWTAKQETRAYHGEHLT QRKTQNLHSLSRGRVRASMNKYNLFNLYKKAPVRYDGKTLYQQKWNAKAETRAYHGEHLT -RRTQNLNSMARGRVRASMNKYNLFNLYKKPNVNYQGKTLFQQKWTAKAETRAYHGEHLT NRKGTLLNSLARGRIRASFNKFNLFNLYKKGQVNFRNKNLYQQKWTAKQETRSYHGEHIR PHKAKNLFSLARGKVRASWNPRNLYNLYKKTDFLRDEKTLFQKKWASKRELRAYHGEHIR ESRWQTMFSPKLDSVAQLDASLRGGVTKETPFLMQTFATLEKRLDFAVFRAMFASSVRQA ESRWQSVFEPQLNSVAQLDASLRGGDIEPTPILLQTYAVLEKRLDFALFRAMFASSVRQA EKRWQNAFKPKLDSVAQLDASLRGGEIKETPFLLQTFAVLEKRLDFALFRAMFASSVRQA EGRWQQFFDPKLASVAQLDASLRRSASSPTPFLLQTYAVLEKRLDFALFRAMFASSVRQA EKRWQTVFKPKLDSVAQLDASLRGGEIKETPFLLQTFAVLEKRLDFALFRAMFASSVRQA EKRWQNAFKPKLDSVAQLDASLRGGEIKETPFLLQTFAVLEKRLDFALFRAMFASSVRQA EKRWQTAFKPKLDSVAQLDASLRGGEIKETPFLLQTFAVLEKRLDFALFRAMFASSVRQA ERRWQTAFKPKLDSVAQLDASLRGSEIKETPFLLQTFAVLEKRLDFALFRAMFASSVRQA ------------------------------------------------------------ ESRWQSTFSPRLTSVAQLDASLKGGDVAPTPILMQTYAVLEKRLEFALFRAMFASSVRQA ------------------------------------------------------------ EKRFKNLFDSNLKTYSQLDASLKGHDVAPTPITLQTYGTLEKRLEIALFRSMFASSVRQA EGRWQTTFTPKLDSVAQLDASLKGGEMEQTPILLQTFAVLEKRLDIALFRAMFASSVRQA ESRWKQIFKPNLESVAQLDASLKGVEVAPTPMPLQTYAALEKRLEFALFRAMFASSVRQA EKRFKNLFDSNLKTYSQLDASLKGHDVAPTPITLQTYGTLEKRLEIALFRSMFASSVRQA EKRFKKLFDPELKTYSQLDASLKGEAVAPTPITLQTYAALEKRLEFAVFRSMFASSVRQA EKHFKNLFDKDLKTYSQLDASLKGRDVAPTPITLQTFGTLEKRLEVALFRSMFASSLRQA ERRWKTLFNPSLESVAQLDASLKGVDVAPTPMPLQTFAALEKRLEFALFRSMFASSVRQA EKRWKAIFDPSLETVAQLDASLKGSKVAPTPMTLQTYASLEKRLELAVFRSMFASSVRQA EGRWKQLFKPNLESVAQLDASLKGMDVALTPMPLQTYAALEKRLEFAMFRAMFASSVRQA EGRWQSMFQSKLDSVAQLDASLRGSAVQETPFLLQTYSVLEKRLDFALFRSMFASSIRQA EGTLTTQIPKKLQGVV-LPNRFDDQMLEKTPFAMQTFVHLEKRLDFAVFRSMFAASIRQA RQFILHGNVYVNGVKIKHPGYTLKPGDTFNVKPEKVLQALGSKKPSFEEALKVDKKQKEA RQFILHGNVHVNGVKITSPGYALKAGDVFNVRPEKVLQALGAKKPSLKEALKVDNTQLEA RQFILHGNVRVNGTKMKHPNYTLKPGDMFSVKPDKVLEALGAKKPSFEEGLKVDKTQKEA RQFILHGYVKVNGVVIKHPGMTLKPGDLFSVKPAKVLQAMGAKKLSLLEALKVDKKQKEA RQFILHGNVRVNGVKIKHPSYTLKPGDMFSVKPDKVLEALGAKKPSFQEALKIDKTQKEA RQFILHGNVRVNGIKIKHPSYTLKPGDIFSVKPDKVLEALGAKKPSFEEALKIDNTQKEA RQFILHGNVRVNGIRIKHPSYTLKPGDIFSVRPEKVLEALGAKKPSFEEALRIDKTQKEA RQFILHGNVRVNGVKIKHPSYTLKPGDIFSVKPDKVLEALGAKKPSFEEALKIDKTQKEA ------------------------------------------------------------ RQFILHGNVYVNGVTMKHPGYPLKAGDMFSVRPDKVLEALGARKPSLEQALAIDKQQTEA ------------------------------------------------------------ RQFILGGYVKVNGVVIKHPSFPLQSGDVFSVDPEKVLFALGKTKPSLEKALSVDKKQFEA RQFILHGNVFVNGIKIAQPNYTLKPGDVFNVKSEKVLQALGAKKPSLQEALKMDKLQRAI RQFILGGHVKVNGVVVKHPSFPLQSGDVFNVKPEKVLLAMGRVKPGLEQAIKVDNNQKTA RQFILGGYVKVNGVVIKHPSFPLQSGDVFSVDPEKVLFALGKTKPSLEKALSVDKKQFEA RQFILGGFVKVNGVKIRHPSFPLKSGDVFSVDPEKVLFAMGRAKPSFEKSVKIDDKQSLM RQFILGGFVKVNGVVMKYPSFPLQSGDVFSVDPEKVLYALGKDKPSLEKALSVDRKQYEA REFIKNGHVKVNGVTIKHPAFPLKSGDIFSVNPEKVMLAMGRVKPSVAEAIKVDKKQSAA REFILGGSVLVNGVVIKHPSFPLKSGDIFHVKPEKVLLAMGRTKPSLEKAIKVDNQQKAA RQYILNGYVKVNGVIIKHPSFPLKSGDIFSVIPEKVLTAMGRTKPSVQKAISVDSTQKTA RQFIIHGNVYVNGTKVKHPGYTLKPGDMFNVKPEMVLKALGYKKPSLLEGLKIDKIQDRA GQFIRQGNVTVNGVKIKHASYTLKPGDLISVKPEKVLFAAGKAKPSVEEAVKIDNRQKKC KTNPQKAWSDKKKHEFLKRLKKEDTNLQNEEYKILKALTPKILASIKAKDDTTEEFKTTI RKNPRKFWDEKKKQEFLSFLENYNKTMHIQMRKELDQTSNELLASTVNDVEKLGEFYNRE KTNSKEVWDNKKKLQFLEFLKQYNKNLESQQYNALKECTQEILINVMGKLDNEDELKKSV KENSREVWNKKKKIKFMEFLKMYNKSLESAQYNDLKNCSPEFLNSIIAKEGSNKNFESEV KTEPKEVWEKKKKLQFQEFLRQYNKNLESQQYNALKGCTQEILRNVIGKSNNEDELKQSL KTDSKEVWGKKKKLQFQEFLKQYNKNLESQQYDALKECTQEILTTVIGKLNGEDEFKKSV KTDSKQVWEKKKKSAFQEFLKQYNKNLELQQYNALTECTQEIVNTIIGKSDNEDEFKKSL KTDSKEVWERKKKLQFQEFLRQYNKNLELQQYSALKECTQEILRNIMGKPSNDDELKKSV ------------------------------------------------------------ RNNPREAWQGKERQVFVELINHNNKQLDEKKLAVLKSTDKELLCAAHDGEKSITASYGAL ------------------------------------------------------------ KKNPEKIWDLKKQVEDFEKQKKSVQNAQKLMKIQQNQVTRQILQQLASEPASLETFNKAR KESPREEWAKKKKQEYLEFVRKYNATLTSEMESEIKGATKEILALAAAEPENPSHFFDKA HANPREVWELKSSASNKEMIRKFNQVIDKEMIKQQKNTTREMLSS-LASKHGEDIFNENA KQNPEKIWDLKKQIEDFEKQKKSVQNAKKLMKIQQNQVTRQILQQLASESASLETFSKAR KKDPERVKQMKEVFKKQEILNRRKSSSNRNMKAKQNLVSNKILKQLASGEVSAESFRKAD KKNPEKIWNLKRQAEASEQHKSSVNSAKKLMKIQQDQVTREILSKLAGAAVSEETFNKPS KQNPKDVWDLQVQLSRLESVKKFNKDVERKMLAEQKQTTRELLSSAIEGKDVDSAFSKDS QENPREVWEAKRNINGSESAEEFNKKIEQTMKSQQNDATREILLSLIESNGGVETFKENA KTNPQETWQLKESLTHKEQVKRYNEQIEKSMLAKQKSTTRDILSTLTEEVSPNKE---NK KKNPRLVWETKEKQKFLSMLKEYRKNIETEELSEVKTCTPEILSEVQAQSNKENDFKSKV NDDPEKMWNVRMDPKTQMQLQKANEVAFQAMLARLRELCSAIFETGFLKTQTDEKLLKPV HKIYETYLFSKTILLDLKGNKEEIKEANSSFDPKWAENLKYHPRLDLEAIKEDEVKARIN VKSAKAVETIAGKPLAIPNEQGELLKVDIPYDAKWAEKLPLHQKINVPELLENEPAAQIN HSAYQDFFKSGGLKRELSKKSVEISSGSIAFDPNWAKDLKYHDPIKASELESDEQKVRIN FKCYQDLLKLDELAYELKEKPAELKESTIPFDPQWAQRLQYHDAIKIEELQEDEKKAQIN NNAYQEFFKSGEIRREISKQPDELISGSLTFDPKWAKNLKYHDPIKLSELEGDEPKARIN YSAYQEFFKSGEMKRELSKKPEELTSGLITFDPKWAINLKYHDPIKISELEGDEQKARVN YSAYQEFFKSGEIKRELSKQPEELTSGSLTFDPEWAKNLRYHDPIKISELKDDEQKACIN NSAYQEFFKSGEIKRELSKQPEELTSGSITFDPKWAKNLKYHDPLKISELEGDEQKARIN ------------------------------------------------------------ FEIYKTLEKSEALKI-LQDTAEEQAKLEMPYDSEWVESLRLHPQLKTKELLEDPAAAQVN ------------------------------------------------------------ TKCLQIYQTLTNKNHPTKDSTKNIEGDTKFFQTSFAKALRGVPKLNKEEILEDESKAKVQ AECFK-ELQNAKLILPSASSLPELIDLAIPYDPLWAKKIQGHAPINIAELAEDEAKARIN FKCNEIYQKLAESKHILKQSIEDAKRKTIPYSSDFSKNLKIHKKLDKDAIVEDESKATVN TKCLQIYQTLAKKNHPTKDSTKNIEGDTKFFQTSFAKALRSVPKLNKEEILEDESKAKVQ EKCLKIYNILAQKKHSLDNSEEALDKNVTPAVLEKTTKTKFVPQLNKEEILEKGE--YPN AKCLQIYQGLVEKKHPISESEENISKGNKFFESSFAEKLKPATKLNKEAILEDESKAKVT AKCLEIAKILSRAESPIAASPEKCKEKTIPFSTSFGKNLKPHPPLDKDSVLEDEKSAKVH QKAHNVYKKLSDAKHKIGENIENAAELTASFTSDFVKLLVPHPALNKESILEDETLANIK EKCYKAYTLLKENDHALKDSVESAAAKSIPFSPQFAENLRFHPPLEKEAILEDESKASIN FSCFQEFSKSGLIKNDIKGKATELKTDTLPYDEKWVESLSLHKPINPVELGENELKARIN APTAEGFLTPEAVIELNERTKLAQEAPSVQVNPRWLQLLPLREKIDAAEAAENEAEVA-- LPWQYGRKDSNKPYFTPWKPRPFLAPFAILPHHLEISFKTCHAVYLRDPVARPGHSEVIS LPWQFGRNDPSKPYFTPWKPRPFLAPFAILPHHLEISFKTCHAVYLRDPVARPGQSEVIT LPWQYGRQDAKKPFFTPWKPRPFLSPFAILPHHLEISFKTCHAVYLRDPVARPGQSEVIS LPWQFGRQEPSKPYFTPWKPRPFLAPLAILPHHLEISFKTCNAVYLRDPVARPGHSEVIS LPWQYGRQDPKKPFFTPWKPRPFLSPFAILPHHLEISFKTCHAVYLRDPVARPGQSEVIS LPWQYGRQEPKKPFFTPWKPRPFLSPFAILPHHLEISFKTCHAVYLRDPVARPGQSEVIS LPWQYGRQDHKKPFFTPWKPRPFLSPFAILPHHLEISFKTCHAVYLRDPVARPGQSEVIS LPWQYGRQDPKKPFFTPWKPRPFLSPFAILPHHLEISFKTCHAVYLRDPVARPGQSEVIS ------------------------------------------------------------ LPWQYGRQNPNKPYFTPWKPRPFLAPFAILPHHIEVSFKACHAIYLRDPVARPGHSEVIS ------------------------------------------------------------ LPWQFGRKDPSRSYFTPWTPRPFLGAFAILPSHIEISFDTCHAIYLRDPVARPGHSEVIS LPWQYGREDPSKPYFTPWKPRPFLSPFAILPHHIEVSFKTCHAVYLRDPVARPGQSEVIS LPWQFGRQDPSKPFFTPWTPRPFIGCFAILPSHIEISFNTCHAVYLRDPVARPGHSEVIS LPWQFGRKDPSRSYFTPWTPRPFLGAFAILPSHIEISFDTCHAIYLRDPVARPGHSEVIS LPWQYGREEPERSFFTPWTPRAFLGSFAVLPSHIEISFDTCHAVYLRDPIARPGHSEVIS LPWQFGRKDPSRSYFTPWKPRAFLGAFAILPSHIEISFDTCHAIYLRDPIARPGHSEVIS LPWQFGRQDPSKPYFTPWTPRPFIGAFAIMPHHIEVSFETCHAVYLNDPVARPGHSEVIS FPWQFGRQDPSKPYFTPWTPRPFIGAFAILPSHIEVSFSTCHAVYLRDPIARPGHSEVIS LPWQFGRQDPAKPYFTPWTPRPFIGCFAVLPSHLEVSFSTCHAVYLRDPVARPGHSEVIS LPEQYGRKNPNKPYFTPWKPRPFLAPFAILPHHIEVSFKTCHAVYLRDPVARPGHSEVIS FPWQYGRQDISKPYFTPWRFRPFISPSVIYPHHIEVDFTTCSAVYLRDPVARPGMSEVIS PFDIPVHERAYMYYIRRG------------------------------------------ PFGLPVHERSYMYYVRRGIRVKRRRVQALLLEEERNAKKGKFVFKLSKTVELETPDVNSP PFDVPVHERAYMYYLRNG------------------------------------------ PFDIPIHERAYMYYIRKG---------MTVLDEDKKRK-STFIFKLTKTVNPSSYEASTP PFDVPVHERAYMYYLRNGIRVKRRRVQALLIDEGKRVKKQKFIFKLSKTVSSESYESSTP PFDVPVHERTYMYYLRNG------------------------------------------ PFDVPIHERAYMYYLRNG------------------------------------------ PFDVPVHERAYMYYLRNGMRILCRHYTILVIDEGKRVKKQRFIFKLSKTVSPESYEFSTP ------------------IRVKRRRVQALSVDEGQKKRKGRFIFKLARTVNSDSYEALTP PFPLPVHERAYMYYLRKGIRVKRRRMQALLLEESRLNKKGKYVFKLARTVELQGSNEETP ------------------------------------------------------------ PFPDHVHERAYMYYVRKGLRIKRKRLQALILEDRRSVKRHNYVFKLARTDESDKVSIIQT PFGMPVHERAYMYYVRNG------------------------------------------ PFPDHAHERAYMFYARKGLRIKRKRLQALILEDNNAAKRNNFYFTLTRTDESGAIAVIES PFPDHVHERAYMYYVRKGLRIKRKRLQALILEDRRSVKRHNYVFKLARTDESNKVSIIQT PFPEHVHERAYMYYIKKGLRIKRKRLQALILEDTRNVKRLNYLFKLSRTEESLRTNIEAT PFPDHVHERAYMYYVRKGLRIKRKRLQALILEDRRNVKRLNYVFKLARTDESDKVSIIQT PFPDHVHERAYMYYVRKGLRIKRKRLQALILGA--ASKRKSYYFQLNRTDQAH--DVSGS PFPDHTHERAYMFYARKGLRIKRKRLQALVLEDRRAAKRLNYIFKLARTDTLENTTILQS PFPDHVHERAYMYYARKGLRVKRKRLQALVLENVPASKRGSSYYLLASAGTSELADAVFS PYGLPVHQKAYMYYVRSG------------------------------------------ PFPLINHEFANLYYIKK------------------------------------------- -------------------------------MVNKYLTLNKDSNSRKKRKPSRKHFRGAA LLNENNDKKMVYVLERERERQAEELPDSIAEMLNDYLKIKEKDPEHKKRKASRKHSKSYT -------------------------------MVNDYLKFNKDVEETKRKKPSRRYFSENA LLKLSNVDNRHFVLEQHGKRRRDELPPEINQMIEQYLTLTKKEDNTRRKKPSKKHFTGES LLKLAHEDHRHFVLEQRKKSRRDGLPPEINQMVNDYLKLNKGVEKTERKKPSRKYFTGDS -------------------------------MVNDYLKLNMGVQKTEKKKPSRKYFSGKV ------------------------------------------------------------ LLKLAHEDHRHFVLEQKKKRRRDGLPPEINQMVNNYLKLNKGEEKTERKKPSRKYFSGDS LSKSAANDHRHFVLEREGKRRRDDLPPEINQMVSDISNLNKNDEQNRPRKPSKKHFGGSN LLKLAASERNVYVLEQQKQTQK-CLPEEISEMLEEYLRLETKATASEHKRPSKR--RASQ -------------------------------MLNEYLSISGSNPTSLDRKGRKQSRRHTA ILNLSEPTKRNFVIPKHQTEEDIEIPNELSDMLDSFLSLEKNN-DTKRRKRGRRNTSEES -------------------------------MLNDYLSLESRSSRALKRPGGRKSEPNVN ILNSNVNRKRKFIIPKRQTEEDTYIPNELADMVSSLLTSRHNVSPQRKRRNRSGNSASNL ILSLSEPAKRNFVIPKHQTEEDIEIPNELSDMLDSFLSLEKND-YSKRRKRGRRNTSEES ILLRANEIKRRFIIQPNDDDDDLKLPNELSSMVQSYVFTEASSPLQKRKRRGRTAVIQEN IIPENNHQKRNFIIPKHQTEEDIQIPNELSDMVDSFLTLEHDDKKKRKLRGGRRASNDSS VLSAASGSGRHFVIPKRPNDVDTVIPHELADMVDTFLHVEDQP-TRRKRRGRQKTESPEE VLNSNSNRKRKFIIPMRQTEEDVTIPNELSDMLSSFLSVGKENIRKKRTRGIVSNEIHES VLDVGASKKRKFYLPK-SSWEDPAVPDELSDMVQSFLDVNGSENSSHKRRTRNRKENAEN -------------------------------MLAKYLQLNNDDVEESRKKPSRKHFKGDA ------------------------------------------------------------ AEVKSLPSQDYVYDVYHLEQVPEDEYNKY-EGSKVGFIKIIDVYGDLLPDELTDSDEQFL API--LPPTDYVYDVYVKQTIPEDEEEFVFDKSTIGYIRIVEHNGDMIPEEEVDPEKTML AEISSLSGLDYVFDIYHLEKIREEEVAKYNNEKNIGFVKIIEQID-LALDEESDP-NEAR AKIATLPSLDYVYDIYHLESVPEDEMTRY-EQQNVGFVKIVNKDMDLLPDEEEDSNNEIR AKIASLPSLDYVFDIYHLEKIHDDEVARYNNEKNIGFVKIIEHID-LALDEESDP-NEAR TEIVSLPSLDYVFDIYHLEKIREEEVAKYNDEKNIGFVKIIEYID-LALDEESDP-NEAR ------------------------------------------------------------ AKIASLPSLDYVFDIYHLEKIHEDEVARYNNEKNIGFVKIIEHID-LALDEESDP-NEAR REVVSLPSNDYIYDIYHLESSKDDDLNSY-KYEDLGFVKIVNKFIDLVPDEDT------- LPVAQLPSMEFVYDIYIRENLPEDE--FVWDKNTVGYTRIVEDNGALVPEQDASADTQQL VDIPKMPSIDYVYDIYYRENVQEDE--FVFDKSTVGYIKIVEEDGSMIPREDDDPDEHRL SRPTQLVNAQYVYDVYHLTDS-EPMTSANHPSTQIGYIRFFEDENELMNDEEDETKPNVL SNI--LPSIGYVYDIYYREVVPEDE--FVFDDSTVGYIKIVEDNGDLIPEEEEDDNSLAA GDTPIVPETDYVYDVYQLSLT-EPMTTANHPQSQIGYIRFFDEDNDLYQSDEEKNTNNMF SRPAQLVNAQYVYDVYHLTDS-EPMTSANHPLTQIGYIRFFEDENELMNDEEDETKPNVL VKLFSSPPLEWVFDVYHLTTANEPLTSANHPTSQIGYIRFFDDDEEFLNAEDDDTKPSVL SGTSMNRNQQYVYDVYQLSES-EPLTTANHPSSQIGYIRFFEDDNDLINEEEDENRPSVL DPGASGPPADYVFDVYTLS---EPLTSQNFPQSEIGYIKFFDDKD-YNLMNSDDSAESAH SETPEIPAVEYVYDVYQLTST-EPLTTANHPQSQIGYIRFFDDDDDFYESDQDETKPTVF SAPVEIPS-EYVYDTYHLS---EPMTSANHPQSQIGYVRFFDEENDLYQSDEEDDAHKVY ARIATLPSLDYVYDIYRLENMKDED--EQLNRLKIGRVKIVNIDTELVHDEESDDNGLNV ------------------------------------------------------------ SDEEDSNDENYYRNDYPEDEDDDRSILFGSEGEELETEFLANHDVDEFETDSADVIRPRE TDDEDSNEEDYYQNDYPEDEDDDRSIFIGSDEDREDIVYLDELNDELDQNYNVDGEQANE SDDEDSNEENYYQNDYPEDEDDDRSILLGSEGEDSEEEIVLGVNKSRFSSWNDDQILGPN SDDEDSNEENYYQNDYPEDEDDDRSVLFGSEGEEEEDE------KNNKQPWNYDKILRAD SDDEDSNDENYYQNDYPEDEDDDRSILFGSEGEDLGEEIVIGVNKSRFSSWNDDKIQGSN SDDEDSNDENYYQNDYPDDEDDDRSILLGSEGEESEEEIVLGVNKSRFSSWNDNKILGPN ------------------------------------------------------------ SDDEDSNDENYYQNDYPEDEDDDRSILLGSEGEDLEEEIVLGVNKSRFSSWNDDKILGPN ------------------------------------------------------------ SDDEDSNEEDYYRNDYPEDEDDDRSILFGSDLEQMANPLQSPVSEI-------AELITEA SDDEDSNEEDYYQNDYPEDEDDDRSILFGSEENE-EGSDVTGANFIEEHTHDDTAV---- TDDEDSNAESFYQNDYPSDEDAGAFSEQDSLEEE------------------NEGYVPHD SDDEDSNEEAYYRNDYPEDEDDDRSILFGSEEGAGRNSLASSDGSSGLNNLDAESMRGHV SDDEDSNAESFYQNDYPSDEDAGAYSDTYTEEDI--EIIQLQDGQDSQDEYISSGTKPDE TDDEDSNAESFYQNDYPSDEDAGAFSEQDSLEED-------------------EGYVPHD TDDEDSNAESFYQNDYPSDEDAEGLDELNSFDEKFDKLNIGDGDEVSGNEEDDYGYEPKD TDDEDSNAESFYQNDYPSDEDDGGLIV--------QDDMLNNDDIINGNDDDDEGYVPHD SDDEDSNAESFYQNDYPEDEDAGAFSETYDDESDDEDNIGPVILESAEAAYLRGQEQAEG SDDEDSNAEDFYQNDYPSDEDAGAYSETNSF------------------EVEDDDEDQED SDDEDSNAESFYQNDYPSDEDAEG----------LDPEVILQ-----------DGEEAPD LEDDDSNDENYYRNDYPEDEDDDRSILFGSDGEEEEETWIARQYEEQRRNETGHGDSVTD ------------------------------------------------------------ DYDPKIATYDDVFSLQGSSNILRSINDANFIDLDRDEGSDGEFMYNEEFPRNEFFPTDKD TTNDNGDEFDALFQYGESSNLLSSLNANNYVDFDYDDSDNDNGKYDGDFKRNYFFPTDKD GYQDVEEEYGDLFNLGGNSDLLKSINSSNFVDLDDPENEIGTSDNDDDYPRNEFFPTDAD EGDNANDEYTELFNLDGSGNILKSINKNNFVDLDKPEATDSDAEEEDIYPRNNFFPTDED GYHDVEEEYGDLFNLGGKSDVLKSINSSNFIDLDGQEGEIEISDNEDDYPRNEFFPTDVD GYQDVEEEYGDLFDLGGNNNVLKSINSSNFIDLDGQENETERSGNEDDYPRNEFFLTDAD ------------------------------------------------------------ GYQDVEEEYGDLFNLGGKSDVLKSINSSNVIDLDGQEAEKEISDKEDDYPRNEFFPTDAD ------------------------------------------------------------ GSE---DIYDPLFELGAEPNLLSSLNSNNYVDLDVDSDREDASNGRTFFERHNLFPGEED ------DEFDPLFNFDTEPDLLSSLNAHNYIDLDYDDDYEDEGDGDDDIQRHRFFPTDDE GVGFKGNEYFDYEE-------LENLDAEDNY-----YEEEEEADYEDEFKRNQFFKSDID AMLGE-NETDLLFQFSGVPDVLKA-AGHELYDLDDDLAGDSDEELQEEFKRHNFFPSDAD GFE---DLYDDFYD-DGDNDI-NPLAEDQYHNVDNDQE----------LERNHFFENEEE GVGFKGDEYFDYEE-------LENLNAEDNYYED--EAEIDESNG---FKRNQFFKSDVD GIGFTGE--EEYFDYGEVERYMGYQDEEHYADD---DDYN--SDEQV-LRRQQFFKSDVD GVGFTGDEYYDYEE-------LENLDNEDYYY----EGNAGDDEGERDFKRNKFFASDTA QFD---DLYDEFFGSEQPVDFLAETNDD--------------------YERQNFFKDEED EYGIIAEDDDEIEDYGE----IAYLEEDKYY-----VDTTTLEDED--FKRNRFFEDDED ELGNTDELYENFFH--------GDDSPVNFVEDGSE------SEHEQ-FERQRFFAHDED DYQSQDQEYSGLFAFNGSVDILKSINSSNFIDMDGQDNIDDDDDYDDDLKRNEFFSTDQD ------------------------------------------------------------ DPVAIHRDRIFHRLQKMIEKD---------------MATEAGTGQMTKESLRDA-YRSIK DEDAIHRDRIFGKLQKMIDKV----------------MDSRTNGARNRPESKKSSHHSLR NPLAQHRDRIFHQLQNKIERR--------------MAPHENKHPKYDRATFQKT-YSSMK DPLAQHRDRIFGQLQKKIDEH---------------MPSNSNTMNRRVEPLTTA-YKSIK DPLAHHRDRIFHQLQKKINRS------MTWILSTGMGPHEDKYAKHERATFKKT-YSSMK NPLAKHRDKIFHQLQEKIDRR------MTSILSSSMAPHEDKYAKHDRATFKKT-YSSMK ---------------------------MTWILSTGMGSHEDKYGKHDRTTFRKT-YSSMK DPLAHHRDRIFYQLQKKIDRS--------------MGPHEDKYAKHDRATFKKT-YSSMK ------------------------------------------------------------ DPMAIHRDKVLGKLQRILNGAHINSALNHSFVGAPQNAYYHHGSRTESPPESSSSYSSLR DPVAIHRDEIFGKLQKMIERR--------------------------------------- DPIAIHRDKVFSKLENMINNKATATINASNFSSPPVPSYEASQRMHNQIPITSSKRSSIK DPLAIHRDRIFDKLQRMINKRQLPVSLESRSSQIHIHHHHHYHRRTSSEGGSQATYQSIK DDLAIHRDIIFGKLKKMIDER--------------------------------------- DPMAIHRDKVFNKLENMINNKATATINTTNFSSPPVPSYEASQRMHNQIPITSTKRSSIK DPIAIHRDRIFGKLEKMINEHNRRSSSSISSSALGPNTYANENTISSQQNLQQNQQSSIK DPMAIHRDKVFGKLERMINDSNNNNSNSTNEAIPPVPSYEASQRMHNQTPIDDLKRTSIK DELAQHRDRIFGRLQKMIDEKVGTLRRMMPVQHAAIPSYESSQEQHRRRLAQRVRGRSLK NELAIHRDRIFGRLEKMINENALCVASGVDYMAIGVPSYETSQMLHDRSSFVADKRNSLK DEVALHRDKIFGKLQRMIDE-PIATTAASPISATPVPSYEVSQRLHEQPPLLRTPKNTLK DPLAIHRDKIFGKLQRMIDERIILNSSNVSNNTNSNNNNNNNNNKKKSLPFMKV-YASMK ---------------------MFRRKPNTPSPEVSRTSSSSNLASHNS------HHPPLK KMSLNHLSAKQHLLMALCRDVSMLPPVYYTFMSLKKAWQISIQTTILYEPQSLRESLIAF NLTLTHLTAKQHFLIALCRDVSLLPPIFAMCQSLAKAWSLSFETNVLYSGSGLTNKMKMA TLSLNHLTAKQHMLMALCRDISLLPPLTYIFTSLRKAWRVSMRTSILYEPQSLRDAFTYF TLSLNHLTAKQHLLMAICRDVSLLPPIIYIFTSLKKTWEISFQTKLTYDPQSLKDALMSL TLSLNHLTAKQHMLMALCRDISLLPPLTYIFTSLRKAWRVSMRTSILYEPQSLRDAFTYF TLSLNHLTAKQHMLMALCRDISLLPPLTYIFTSLRKAWRVSMRTSILYEPQSLRDAFTYF TLSLNHLTAKQHMLMALCRDISLLPPLTYIFTSLRKAWKVSMRTSILYEPQSLRDTFTYF TLSLNHLTAKQHMLMALCRDISLLPPLTYIFTSLRKAWRVSMRTSILYEPQSLRDAFTYF ------------------------------------------------------------ NLSLYHLTAKQHFLIAICRDISLLPPICSGISSLRIAWEFAPDRQYLSVVAVFRRSLLKF ------------------------------------------------------------ QLGLKFLNARQHFLLASCRDVSLIPPLIGLIRSWRMIYSN-------------------- SLTLNNLDARQHFFIAVCRDVSLLPPLLSLAYSLKKAWTLRKDLLYLDDSASLTAGFTKL ------------------------------------------------------------ QLGLKFLNARQHFLLASCRDVSLIPPLIGLIRSWRMIYSN-------------------- KLGLKLLNARQHFLLASCRDISLIPPLFGLFQSWKRISH--------------------- QLGLKFLNARQHFLLAFCRDVSLIPPVIGLVQSWKLSY---------------------- SLGLQFLNARQHFLLAVSRDISLVPCLVGLFQSW---WVL-------------------- QLGLKFLNARQHFALAISRDVSLIPPLIGLIQLWKRAFVD-------------------- SVGLRLLNARQHFALACSRDVSLIPCIVGLFQSWSRVF---------------------- TLSLSHLTAKQHLLMAICRDFSLLLPIIYFCNSLKKAWEVSSKKSIIYDIQSITEMLSLL ILGLKFVNARLHFLLAVSRGLSVLPPFLGLYRCLLDAWKH-------------------- WVQFSNLRTMENVTQHNVNNTSAENWLFTALTKARASEHLFCALWCLVSLYLTYAILDSL WSAYIGTTT----------STEDDTIILSALTTARSSEYFLASMWCLVSMYLSYSILDSL WSAYDNYSSSDGSRQEVASGDSKDSLLLSALTTARASEYLLCSLWCVVSLYLSYAILDSL WTTTTTTIAAAAIVSAVSTNQQINSLLLNELITARASEHFLCALWCLVSLYLTYVILDSL WSAYDNNSSFEGASQKAVNGDGKDSLLLSALTTARASEYLLCSLWCLVSLYLSYAILDSL WSAYDNNSSFDGSSQETMSGNSKDSLLLSALTTARASEYLLCSLWCLVSLYLSYAILDSL WSAYDNNSSFDGAPKKGVSGDDKDSLLLSALTTARASEYLLCSLWCLVSLYLSYAILDSL WSAYDNNSSFEGTSQEAVSGDSKDSLLLSALTTARASEYLLCSLWCLVSLYLSYAILDSL -VRYSGYRAXH---------------ITASLTTARASEYLLCSLWCIVSLYLSYSILDSS VRQQNGELGDVGAISRLSSALDNHTWLQSALRSTRSSEYLLCSLWCLVSMYLSYSILDSL ------------------------------------------------------------ -DTNNYSQVLNG----------------DGVTLIRGSEHFLTGLWCIVAGYLSYSILDSL WQAYRSLKT----------QASSGPWLSSQLISARSSEYVLSSLWCVVSAYLTYAILDSL ------------------------------------------------------------ -DASEYSQVLNG----------------DGVTLIRGSEHFLTGLWCIVAGYLSYSILDSL -EEVNNMILNNTSSNPLVT-------PIPKITTAMGLEHFLTGVWCIVAAYLSYSILDSL ---YNEHKVD----------------ILDN--SPRGCEYFLTGIWCIVSAYLSYSILDSL ---LKGPSVSAGS---------------SGITSARLSEHFLTGVWCIVAAYLSYSVLDGL -SHYMVDSINSANLSETSQ-------HLKSITSARQSEHFLTGLWCLVAAYLSYSVLDGL -AGYAVEELAGQP-------------LQTSITSARMSEHFLTGVWCIVAGYLTFALLDGL WKSSSSFSSSSSSTTHLSSDLGRENLVLDSITRASSSEYILCALWCLVSLYLTYSILDSL -RMGDED---------------------SAISSTRSSESIMAGIWCIVAGYLAYAVLDGL MVRWIVKYSTLAAILRMFSMSMIIITFELMLLASLSPEKNYFLHTWITISCILTAVYIWQ MVRWIIKYATMAAIFRMFSMSLVMICFELLLTAAMSPSGKYHLHTWILISCLLTGGYIWQ MVRWIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQ MIRWIVKYSTVAAIMRMFSMSLVLITVELLLLTSLSPEHDYFLHTWILISCILTVAYIWQ MVRWIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQ MVRWIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQ MVRWIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQ MVRWIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQ MVRWIVKYSTLAAIVRMFAMSLIIITLESMLLASLSPNGDYYLHTWISISCVLTGAYIWQ MVRWIMKYSTFAAILRIFSMSLMIVTVELLLLSSLSPNAEYYLHSWILISCILTGVYIWQ ------------------------------------------------------------ LVRWIMTYSTSAAIVRVLSMSTIIITIELYLINTTSAITDYGLHIWIFISCVLTFTYIVQ MVRWIVKYSTIAAILRMFSMSLLIITLEMLLLSSLSPNGDYYLHTWILISCILTGAYIWQ ------------------------------------------------------------ LVRWIMTYLTSAAIVRVLSMLTIIITIELYLINTTSAITDYGLHIWIFISCVLTFTYIVQ LVRWIVTYSTSAAIVRVLSMSTIIITLEMYFVSAFSAEGKYGLHIWILISCILTLTYIVQ LVRWIVTYSTSAAIVRVLSMSTIIITIELFLVGAFSDSGKYGLHIWLLISCFLTCVYIVQ MVRWIVTYSTTGAIVRMLSMSAIMIVVEQYLVAAFSAEGTYGLHTWIMISCALTILYIAQ TVRWIVTYLTSAAIVRVLSMSTIIIAVEQYLVATFSAYGKYGLHIWLLISCCLTFGYIVQ MIRWIVTYSTSAAIVRMLSMSTIIITIEQYLLSAFSADGKYGLHIWILISCCLTVSYFAQ MVRWIVKYSTVAAILRMFSMSILLVTLELVLLSSFSPQSDYYLHTWILISCILTAAFIWQ MIRWIVTYSTPAAIVRMLSAATLNIVMVHAVHSLISSEQAYQLHIWILISCVLTLAYIIQ SYLTSDLNYVRNGQFSYSTTIEATPDNNSEYEVISNEDSPSQINQRRLNTIGSQQSRSST SFITSNLIYGDNTFPNNSDSSSSRRNDSSSSGDNDDTGNGTSNQGLTFSAARSRKKKLSS SYLTSDLKYYRNGDVDVDEDSHVVAVDEDAVDVLPYDPLSDDSDGRLFPVNRPSSSHSQS NYLTSDLKSFRE-----------------DTTSVSSSSSSSDSDIDTIVRRRRVKKRKQS SYLTSDLRYIRNGEDDADEDSHVVVADESTVDVPSNDSLSDNSDGGLFPVNRPSVSHSQS SYLTSDLRYFRNGEGDINDDPHIVMADDGAVDTSRYDALSDNSDDRLLQVNRPSSTHSQS SYLTSDLRYIRNGVQDVDEDSHVVVADENTMDVLPNDILSDDSDDRSFPINRSLGSHSQS SYLTSDLRYIRNGEDDGDEDSHVVLADENTADIPSNDILSDNSDDGLFSVNRSSSSHSQS SYITSNLNYGVR------------------------------------------------ SFLTSNLSYIEDNTTSTTSEPSTNLSSSAGASIIRTDSLENTNQAPVLISAFGEQSQLRS ------------------------------------------------------------ NFVTSNLELIN------------------------------------------------- SFLTSDLNYVANNSPSPSPAIYRRSSSSHSLASLPDSTQLPQ-----------EGLQMPV ------------------------------------------------------------ NFVTSNLELIN------------------------------------------------- NFVTLNLQLENYAADMPQQPELTRPTASGSSTSLAGTLEPSARMASFTFDAELEPETGLG NFVTSNLEI--------------------------------------------------- NFVTSNIDLKGQ------------------------------------------------ NFVTSNLDLKKG------------------------------------------------ NFITSNLDLRGK------------------------------------------------ SYLSSNLNYVSEDDDDEEDELILRKYDGRAYRVNNNSAESTIRPTSSDSVSTDNSTMTSR NFVTSNLALE-------------------------------------------------- PRSQKRNTVKSIDFTTKRYIDLYNITVFCVVPVGIASFITMVGLLRNLFIQRLDVEQLGR SSSSSSASQFQLRWSKRRRLDLYKVTVFCVVPVGFTSFLTMIVLLRNLFIQRLDVEHMER PRRSKKSSKKAFKFTTKRTIDLYKITVLCVVPVGLASFITMLGLLRNLFIQRLDVEQLER EEHRNKRMEKSFQFKSKRTIDLYNIIVFCVVPVGMASFITMGGLLRNLFIQRLDVEQLTR PKRPKKYPKKAFNFTTKRTIDLYKITVLCVVPVGLASFITMLGLLRNLFIQRLDVEQLER PKRSKKSPKNAFNFTTKRTIDLYKITVLCVVPVGLASFITMLGLLRNLFIQRLDVEQLER PKRSKKLPKKAFNFTTKRTIDLYKITVLCVVPVGLASFITMLGLLRNLFIQRLDVEQLER PKRPKKYPKKAFNFTTKRTIDLYKITVLCVVPVGLASFITMLGLLRNLFIQRLDVEQLER -MDEEKPRRNYLKFSKKRTIDLYNITVFCVVPVGLASFITMIGLSRNLVIQRLDVEQLGR PVRRKRLKKFDFSFSKKRSIDLYNITVFCVVPVGLASFVTMLGLLRNLIIQRLDVEQLDR ------------------------------------------------------------ ------YYKRTTIHKRARFFDFYNIVVFAVVPVGLASFVTMVGLLRSLLLLRIEIDSNNN PPRKKKHVPRALSFTKNRQIHFYNITVFCVVPVGFASFVTMIGVLRNLVIQRLDVEQLER ------------------------------------------------------------ ------YYKRTTIHKRARFFDFYNIVVFAVVPVGLASFVTMVGLLRSLLLLRIQIDSNNN PEPQLRSAVKKKSVKPRRFFDFYNIVVFAVVPVGLASFITMIGLLRSLLILRIDVDQALG ------SSRKGIR-KKARFFDIYNIVVFAVVPVGLASFVTMIGLLRSLLLLRMDIDQLLS --------------RRARFFDFYNIAVFAVVPVGLASFITMVGLLRSLLILRLDIDSQRQ --------------KRARFFDFYNIVVFAVVPVGLASFITMIGLLRSLLILRIDIDQTFG --------------SRARFFDFYNIAVFAVVPVGLASFITMIILLQSLLILRLDVEERTV ERKRRKKSLKSFKFTKKRTIDLYNITVFCVVPVGLASFITMVGLLRNLFIQRLDVEQITL --------------KKARSVDLIQIAVFAVVPVGMASFLTMLGLIRCLTIVQWDIEAAGI MLHESYNPEKKLAILASVYCSKADQLKRIIPYFKALIFQFVQALWPELQDPLDLKFLFDV LLRNSYHNNPQLYLCASVFITRGDSVSEIYQGLRLQYLKLLCVMWPELDAPTNISFVLKD ILHEMHPPEEQLYLLACVFASKADNIRKLATRLKSDYLKIICVLWPELDDPRNLSFLCKQ MLQETLRSADQLYLLACLFASRADNLIRVLHHVSMKFVKIVCILWPELSDPLSLRFLFNH ILHEMHPPEEQLYLLACIFASRADNIKKLSTRLQSKYLEILCVLWPELDDPKNLLFLREL ILHEMHSSEEQLYLLACVFASRADNIKKLVTRLKSDYLKVICVLWPELDDPEKLSFLYKG ILHEMHPS---------------------------------------------------- ILHEMHPPEEQLYLLACIFASRADNIKKLSTKLQSDYLDILCVLWPELDDPKNLLFLCEP MLRPMTNQ---------------------------------------------------- LFKEMSQEKDRLYILLSVLATRGDRVEKCVVYDVQEVLEVICVFWPEVDDPERLWFVYEG ------------------------------------------------------------ GNGMINLGDANLYVYTIQLLTSNNNVHNINAYFLSSNFDLLIYSYPLNIPLQDIIKLAKL IIQQAYTGEDQLYISLCYLSARGDKVLKLISGAVEDILKVICVLWPELDDPLKIGELLKT --------DAKIYISIVYLLSSTTDVDDLSNVFDMDVGKLLIYPTRSYISIENIARFAQG ANSMVNLGDVNLYVYTIQLLTSDNNVNSINAYFLSPNFDLLIYTYPLNIPLQDITNLARL MTTST---DAGLYVSLVQSLALPQNIQNIQQKITPHYVSLLVHTLPGLIPYSIVLQAARY T-------DAKLYVYTIQLVSSSTDIDKLQAFLLSSDTNILVHTYPLNLELEELTKLANL AWISAST-DSWLFFSVCKTLAEKPSFSEIFEKLQLPFTTLITIISPVSISPEQIATVADE EA------MGFLAELLNAFVRDVDDLEEFSNW-------IINATNSGLPNDASLRKTAYD MP------DATVYFELAGMLAESRTNSDLVSILLVQKWPTILQLLALRTSLVVFPVSCLV LIQNSYRSDDKLYLLCTIFAARADNSSLLYDQATQECFDALCILWPELMDPNGLSFVFQQ ---------MSLFLETAKLTASAQALETLLASSKEDILHILLVLTPELLDPKEYMGLVNK DTFNGDLNDILVQCLEQDSSLIPLVEDFNIPPSHSSWIKNRIIHCNNYDKNLLYQPLWSQ IELNGMESSVLVSLIQEDSSLTAISEEETLIGFNEDFIRARTLVVNSLSKDACSELLANS QLVERNKEDVVIKLLEGDNRLIPLIETNKVSSKPEDWLRERILICNEVLPESLYSKLWET QKDAQVDEELVVSLLEKDSMLIPMVENSKWDSLTISWLSKRILLCNDSYPGDFFEPLWNL EEEVQSDEDVIVELLESDSSLIPLIESKKLNNKTEEWLRERILICNEMIPETLLSVLWET GEETPSSEDVVIGLLESDSGLIPLIENSKVDNKPEDWLRERILICNEMLPEALFSQLWET ------------------------------------------------------------ EEMEQSDEEVVVGLLESDSSLIPLIENNKLNNKAEGWLRERILLCNEMIPETLFSVLWET ------------------------------------------------------------ IERERQTGELEFELINSEAELQALVDRSRLEAHSGTFARARTVLVNEVEPDVLFSGIIRR ------------------------------------------------------------ IIYSTQTDEDGFDLEEFSLSLKSDIADTNIKCQSLSFICAKSFYLSQFYQDIDILPLFEN LEQQRIDSTILEALLEDDKELLAMVEDTRFLQTQSTFMKARILFCNALVTDALFKPLWNR VVNYANSEGLYEDLEEFANWISSRFKDNRLQCEQFQFVQAKALFLSKYCTEIVLNPLFEI IIYSKQKDEDYFDLEEFSLSLKPTISDTNIKCQSLSFIRAKSFHLSQFYQDVDILPLFEN ILETSLPVEKEIDNEDNDKDKDKDTEDNLLQETNLGFLQAKTFALSQFYNDLEIDDLFDN LIDPSNVEEFAFGLPENESSLLATAQDTNVQSSYLSFIQAKTIQLSKYFDNVDIMPLYER LFLSNHEADLIEDVEDLSMWITRESPDLKAKSFGFSFIKAKTLQLSSFHHDLELNPLFAL LNAECNSQAFCLLFSENDSASPETIE--------LKFIQAKTLQIAKYFNDIAFSGLFKE EILTSLNSDFLVESNEVAQSLSSRLKVNELQKEIFSFCKVYTCRYSEISRDLACQPLFDL GPSDDQPNDLMMNLLEVDNKLIPIIEILQLEQDSSNWLRRRILVCDEFNPNNLFEPLWET VGKGQLTGSVV-----GDEGFIPELVDSVVPKPVHNFLEERIRLVFKVSHDTLMQLILQS LELTFNEWVNGVLLP---LNNIPNRIHIEELIKMDSAKRITFLLGCMDLGFFSNIFLPML TSKSLVSWLDGILKPLDHLNRRLTKLSIFQFENLSAQDAVSEMWKLPSVSMMKYEVEPYL AETGFFEWVDGIIKPLDHLDKRLIIFKINEWKEMHDDDLFNIIFDGINEEIIEHELIPTL LIKDLFQWIKGIIIPLHSISIRTAMTKIIDFEKMNATVTFPLILDGK----IFHELIPYL AKSKFIGWVEGVLKPLDHLNKRLLIFKINEWEKMPDSELFKIIFDGVIGDVIEDELAPTL AGPGFIRWVDGVIKPLDHLNKRLVVFKINEWKEMPDKKLFNIIVDGASNEIIEYELIPTL ------------------------------------------------------------ AKSGFMGWVEGVLKPLDHLNKRLLIFKINEWEGMPDSKLFNIIFDGVNNNVIENELIPTL ------------------LNKRLSSIKIKEFENMDPLSVFDMILNTP--TVLQRELMPYM LRRGVTAWERGILRPLAHANCSIRPLLVSAFEQLTPAEALELFVEPRAVAVLLHEVVPYV ------------------------------------------------------------ VSFPFNAWFKGIILPYSHFGLAYSINTLNSYLAPESSSRLHLLLGPLLNSWFKNVIIPID LSTDLQKWISGIVKPLAHLNQRCKTMSIKEFQGLSSASAFSFMWQLSQSTILTYEIMPYL LEGYFDKWYRGIIVPWDNYGSLNSLLDLFQFLKSESNEMLHILIEPLSVNWVSKVIMPLV VSFPFNAWYRGIILPYSHFGLAYSSNTFNGYLAPESPLRLHLLLAPLLNGWFENVIFPIV IEFRFQDWNEGVLMPWSNYGAEYSLMSLQTYLQSSYNEKFDKLVQPLQTEWLLQTIIPLL VSSDFQSWFAGVISPYDHYGQVYNGATLQEYLSAGEKNKFEMLITPLSNQWIANVIIPII LNDSFTKWLNGLILPWRNYASLGKCSTSDFLSKFSSDDQFFQLIEPLDISYLNNVILPFL VHSYFLPWFKGLVELWVNYGSLNGSVNFDQFLRLDSSDQFDIMIEPLSVNWFKNVILPLI VSDYFKRWLEGIVEPYSEVCENIDCVNLRRFDSLTSQEQLSVLYEPLPIRWIIRVLLPLT HSKDFAQWISGIIKPLSYLNLRSKTLKIKDFENFKPVDIINLILGNISISIIIQELIPYL GYHNEVDWVAGVPQVINYTRLHGPGLTIDELENGDPSHVIELLGSHLPSDDLQLVLEPYV RYYKELDYYTSHYVNPQTYKLENNNEITILSKI---YEISGSVEVGAKVLGIL----YEN KFQGSYTPFYEVIFNPDNFPLDSINNFQIYK-----YLSSQPTPLDTKFNETKWNILYSN FYGRKWETSISEFFNKQQFSLKSNTNYKLFLKTYFSERLKGNNEAMRNLQSKIVDILFNN DFTNLSNEFIENYFTNENFLLATVQNYDIFRNIFFAFSNETSKSNFDKVCGNVANILFEN SYGKKWETFITEFFNKQQFSLKSDTNYQLFIKLYYSKGVKDNSEASRKLQSNVVDILFHN SYANKWETFIGGVFNEQQFSLRSDSNYHWFLKMYHSEQLKGDSETLRNLQRKVVYILFNN ------------------------------------------------------------ SYGKKWDTFITEFFNKERFSLKSDTNYQLFLKIYYSKKLKDNSEVSRNLQSNVVDILFNN ANGDYYERFLHSFLTTKDFPSNTNYNFEVFYQLILSSRGQETNKYLERFKRQCAYILFKN TFKQAYQEFLDVFLTPEQFPLTTLENFEFLKYMTKTPLFAEQPGKKKVFDRKLLQLLYDR ------------------------------------------------------------ DYYGKLHPLNEWLFDNESKPVESVRKYQFWHVCLKCYDLKDYQIILNSFLSACYFYGFKE AYSGSYEEFLNVIFNEETFPFNTQGNFDVFKMIALESYFPDS--FVPKIQLRIVQILFEK VYQGYFKPLLEWLYFRGDWNVQEPKKYKIWNNAIRSLEISNYENILRFFLGSCYYYIFYE KYYGNLCPLNEWLFDNECSETVASRKYQFWRVCLKCFELKDYEVIINSFLSACYFYGFKE KYHDYIDALDRWMFQ--VYKGSILKKFGLWNIVFRLLMIKMKTKIIPHYLASCYYYNLNG MYHNNFRPLNEWLFYSDGSNKTSPTKYSVWSSCISSFELEEFKVIIETYLAACYYFSFKE AYNGDLDPLSSWMSAKT-----TNQHLQLWDRVSRSFSSHACMNFVRAYVISCVKETIAQ NYNNNFGPLLNWLFLEETVVLSQPRKYDIWNKALKAIGFNDFKDVILYFLASCYYFLYHE KFHNCLDPILNWMVNTSDMKLAEI--FTFWNKCISASSPADSDALLKRFLAIAYYYSLTL KYSKAYDIFLDIVFNPSVFRFDTAVNYYNFRQLYSLNEIP--IEFKEKLEELSLKIIYDN AYKNC------WAVFRDFVSHVTQSNTPLLATLAHNFPESERDAFIQIVLKN----SFEA GNFKSHPDSELRVLLTKIGTEDSS----LHLKLLDLIRDIDDFNSFKTLFDTEAQQYDLF GNLASIPVFELESLIKSFGDDSQIFSGISLNEWLVNLKFMNAK-DLKSLKKDSVVQTSYF SNFNLSSLNELRDILRRFPDDIAIEKNVTVLEMKQFMEFFTNKYSFQEIFAEESAQLAHF SNLNFKSLEELKNILNRIPKDTPIKYDITVADVTEYIRYMEVNYSLKEVYTEESAQLAHF SNFNLSSLDELWSILSGFPDEITIQKTITALEMKQFMEFFIKKFSFKEIFAEESAQLAHF SNFNLSGLNELRTILSELPDDISIQNNVTVLEMKQFMEFFTKKFSFKEIFAEESAQLAHF ------------------------------------------------------------ SNFNLTNLDELWSILSGFPDDITIQKTVTALVLKQFMEFFTKKFSFKEIFAEGSAQLAHF GNLNIGTKYRLNQVLLTIGDETPVDLGITVETLLAYSSLTDKGYHMQDLYADESVQESHF GELAEIPPRELYGLLLLIDETVTLSDGVSVKDLIEYTKYMDANYSLKSMRSDELAQLASF ------------------------------------------------------------ DDVSTIEYDLIIDTITLFDIHTEEDYKDIPFDCHNLKEFQSATNPISPLFQGAIAYLRQV GYLKALPIEEHELILSSINNDICI-NGIELATLKSYSENMHA-FNLKDIRKDELVQKSFF TEVSSIEYDSIKDSLDVIKKRVGSDFD-SLDNSSDLDAFMNDSNPFAQLFNSSISFLHEA DDVSTIEYDLIIDTLTLFDTPPPTNYNNIPFDCVTLKEFQTATNPISPLFQEAIAFLKQV NNLSSVEYDTIKATLANILDNEDEDLSVGSNETMTYKEFSSESNPLAILFKEYAPFLLRA DDVSSVDYEVIHDTLSLLRGSSKTDYGNIPMDCASFNEF-NTSNPLSALFHECIPELKHA EGLSPSKYSQINLTANYLVTTLNIATTLEASAKVATENNSSNENQISMLVKQSLITLQSI NDILTSEYDLIKDTLALLWTEKEASFDIQVSELPAYASFIEFSNPLRPLFESSIVALSEI DKTSM-AYYSIRSTLQFFLDPAEVNNSLKDIKLDSFDQFLRE----NPLVIESVHHLLSI SNLNVTSSSELEQLLTQFSPGTKVSTSLTANNLKWFAHYMNLGYSLSDINASEQEQLAHF N-------DTQWDALALITESPAVASHLTSHFTKQLVETCRLAIPSITLQRTTSGEEVQV TIY-----SRSFRIDNISELE-KDFLFNKLSLRQKLEIIIESLIEKNNLSEVKKLLDEDP SIITQNMFKTVQNVVEFIE---SSTLFDKLTNELQTSILLESLLKLGKFDILEQFVSTSG TSLCHEEFDKTSEIPSFLQSMYDDKIFTRISMDDKIYSIVEIFLQMNEFNYIEMVITRFH ASSCKEELNEESTLSQKLNSLYSSSVFNRLSTKIQQSILLETVLDMGQFDILHEFMSEYG SSLCHEEFNKANEISSFLQAMYDDKIFTRISMDEKLYSILEILLQMNEFAYIEAIIERFD TSLCHEEFSKSNEISMFLQSLYKDKIFTRISANDKIYCILEILLQMNDFRHTEMIIERFD ------------------------------------------------------------ TSLCHEEFNKANDISLFLQSMYDDKIFTRICMDDKLYSILEILLQMNEFVYIEMVIERFH ASLSRKCLSEETTMKELKELLKNNVIFSRLSEQKKLSIIIEISLEFGNFSFLHELIITYQ NSISHYLLAESPSVQTLQFLLSSSKLYPKLTKENQESAIIETLLSLSEFTLLHDFSLQAG ------------------------------------------------------------ IETCQKLLINRLTIKKYFQLKYSIALFQK---ERISATVIERFLLANLFDVVDEVYFEKK ASLCKQLLRSSSALLNYTEVLMNDCIFTKVDSKTKEFMIAESLLASGEFAMLRQFTSDTQ IITCERLYTNKFTILEFLKLKYSARLFTDANNESINKLIIDRFLFNNLFDVVGDFYEKGE IETCQKLLINRLTIKKYFQLKYSIALFQKIRNERISATVVERLLLANLFDVVDEVYFEKR IATCQRLYISQITMQEYLQLKLLILQFKNSNRAKADYVIVERLLMSGLIEESEELVRDHK IETCQKLFINKLTLKKYLQFNYSVDLFKSNTNGQVSSIIIERLLFANLFDVADELFFNDS ARTCDALYMNGLTMGKYFQLKSSIDLFVSSSIRDIDQLIIECLFNGNLFSLVLKYYQSKN IDTCQSLYINKLSIARYLELKNSAKLFYGVEKTKVKEIVLERLLFANLFEVVLELYSTPE IETCSSLYINKLTISGYFQLMTSVDSFVSEQSKDVNKAVLERLLVANLFEESKLFASSKN ASMVKGKIQSQQTIDVISNLIS---IFTNLTIDKQISIFVEILLELGEFDLLQNFVTLNN DLLDDFVFRTSDQWQTFITATELKTVFSTLSDSQVNQKVFEALLGASQFEIAKTTYILGG TPENNELLIKNFWKFFYRSENIHDE--AFKIAETILSMIPSAKRHQLEYLLKNSRDLSQH VKIQDKVIIQHFWRFFNIASNGSLSDPDMKNANRTLNLLSNETHSNLYDILTIVDRLSHY YDEDAKLLVKFFWHFFNNASNGLRKEPEIRKSSQTLQIIQRANLTRMEVLLELADKLSHY ---SNDLLEKYFWKFFNNATNGSCKRAEMIKSQKTLNLLLKKKYERLQSLLDVADEISRY YSNNTELLVKFFWHFFNNASNGLRKEPEMKKASQTLQIIQKTNLTKLEVLLEISDKLSHY YDDDAALLVKFFWHFFNNASNGLRREREMKKASQTLQILQKTDLTRLEVLLDLADKLSHY ------------------------------------------------------------ YSNNAELLVKFFWHFFNNASNGLRKEPEMRKASQTLQILQKTSLTKLEVLLDLSDKLSHY YKVNEEVSVKYFWHFFNMASSGQRHKRDSANARNS------------------------- FQVEKSVILKYFWRFFNSAPNGSRDRPEMTKARNNLRLLPKKDYYYLETLLDVADALAKY ------------------------------------------------------------ DITVNDVVLDKFWDCMNHANSLNDKSGSLHNAELCLKLFDKRDIVKFKHLFKAINALKRF IKIEDSVLLRFFWNFFNNASNGSCKRPDMISAQMILELLPSDRYVHLSHLLNVCDHLSKY LISVDSIILKKFWESFNKASNFNNKIGRLHEASQSIELYDKEEIIRIKHLFKAVSNIKNF DITVNDVVLDKFWDCLNHANSLNDKSGLLHNAELCLKLFDKRDIVKFKHLFKAINALKRF TLSPIEVFMDKFWESFNSANNINDKIGHLHQARRCLDIIEQEKIIALKHLFKAMSAMKNF PISTNSLVEEKFWASLNHAVNLNEKSGLLYNAHQCLNLFDKQQIVKFKHLFKAMHALKNF FISSNDLGVKKFWDLVSTASNIDERIGKMKLAAECLNVLTVYTTMRLKHFVKALGQLKNF FLPVNTLISDKFWDSFNNSSSLNEKIGRFKDANNCVNLFDSDQIIRIKHLLKAIFNIKNF -ISHNELVMAKFWDSFNSASSMNENMDGLKHAHECIKIMDGSDIVGVKHLLKAISNLKNF SKLEENVLEKYFWNFFNNATNGLKSRPEIKKAEKTLQLMDVTVYKHLHTLLKVADTLSRY LVDSEKAILAQFYTFYDAATNGNHTRGSMKSAKLVLGMADTHQFKVAQCLLEATNTLSNY SINLHPHGFKPNYLLNYDEPMAIISNLLELNPKLYKMTDKTQDILSNLNSCFDKKTTEVA SLSFRGMPFKPAHISEFANPMEIVEKLLDLNPKLRKNIEVTFDILKELYTALQVTPSDKE SINLRDAAFKPSNILEYDCPLDIISNLLELNPRLYKDLPTTRGLLSGIYESLSISDEGQI SMNLRGIIFKPSNILDFEDPYQLISTLLELNSSLYKDILVTFTILKKLYTALEKSSLRSE SINLRDTAFKPSNILEYDCPLDIISNLLELNPRLYKDLPTTKSLLFGIYDSLSINREGQV SINLRDAAFKPSNILEYDCPLDIISNLLELNPRLYKDLSSTRGLLSEIYNGLSISEGCQM ------------------------------------------------------------ SINLRDTAFKPSNILEYDCPLDIISNLLELNPRLYKDLPTTKGLLFGIYDSLSIGKEGQV ------------------------------------------------------------ SLSYRGQPFRPSHILDLDDPFRIISKLLETNPSLYRDVETTFEILKQLYEGLQLQPHDPE ------------------------------------------------------------ KLLNRNQPYTPQQLIINGNILKLINIVLEQNPKSYLAFDKLYRILNDMILFYNDDNHKDY FLSFKGVIFKPSTLLEFTQPFEIISKLLELNPQLCRNTNEVFKILKELYGAFQLQSSSPE KIVIKGSPFVPSDLISQRSPMALISTILEQNPKSYLAFEKLYKILNDLLIFFNDNRSEPY KILNRNQPYTPQQLIINGNLLKLINIVLEQNPKSYLAFDKLYRILNDMMLFYNDDNHKDY KIVVKNKPFTPSQLVKFKECFLLITVILEQNPKSYLAFEKLFRILNDLLLYFELDSSTVY KIVIRNKPLTPYALINSNNVMNLITIVLEQNPKSYLAFEKLYRILNDLLIFFGEDGDGEY KLVLKNLPITPQQILNRLSPVSLVSSVLEQNPKSYLAYEKLYKIVVDLALFLEIEDTDSF KLSLKGKPFTPFQLVDKSTPLDLITIILEQNAKSYLAFEKLYKILNDLLLFFEDGTHESY KISVNGQKIVPAQVISKGTPMTLITLILEQNPKSYLAFGKLHKILNDLGIFFGHNLDHS- SINLKGIPFKPCNIFEFYNPSKLISILLELNRDLYKDVANSMNLIDQLVEAMQISREHLE SLTLPGTLTRPVDIRNH-DALQVMDRVLDLNPDAYKNCPKLIHVTRQLLDGLDKSESISI KSKLLALHIDHALVNRDFMFAYQLCKEWFAGKQWLTIFQVGKFIDPEWPDNEAPTEILIL YSKLLSEHINNLLANGDFKFAFDQAINLIE--HWVTIFQVGKYIDPNWLDAEIPTEIIYL EVDLMILHIDYALVNLDFDVAYEMGERVFEDEHWLTLYQMGKFIDPNWVDNEIPTEIIIL YDKLLIIHIDHALVNMDFPFAFNMTKELLERDHWLTIFQVGKFVDPNWLDNEIPTEILMS EVDLMVLHIDYALVNLDFGTAYELGKQVFEDEHWLTFYQMGKFVDPNWVDNEIPTEIIVL EVDLMVLHIDHALVNLDFDMAYEMGKRVFEGEHWLTFYQMGKFVNPNWVDNEIPTEIINM ------------------------------------------------------------ EVDLMILHIDYALVNLDFGTAYELGKQVFEDEHWLTFYQMGKFVDPNWMDNEIPTEIIIL ------------------------------------------------------------ YTRLLVCHIDCALANMEFKFAYDKVIELLEGEHWSTIFQVGKYIDPTWPDNEVPTEIIYL ------------------------------------------------------------ FNKLKTACIESALIDNNFNYAYKQSLELFDDDLWLTFYQVGKYVSPSWFENQVDLGILTK FTRLLVLHIDFALANLDFEFAYQKTQLLLERDFWSTILQVGKFFDPSWIDCEIPTEIIYL FNKLKSICIESALVDNNFQFAYRQSNELLDNDFWLTFYQVGKFISPEWFNENDKIDILIK FNKLKTACIESALIDNNFNYAYKQSLELFDDDLWLTFYQVGKYVSPQWFENQIDFDILIK FSKLKTACIESALVDNNFSYAYTQSIELFEDQFWLTFYQVGKFVSPGWLDNADPQEMQIK FKKLKTACIESALIDNNFNYAYTQSIELFKDELWLTFYQVGKYISPEWFDETIDLEVLTK LPKVQSACIESSLIDDNFAFAYKQSKELFNGRFWLTFYQVGKYISTEWFNEKISAEKILK FNKLKSACIESSLVANDFQFAYAQSMGLFDNDIWLTFYQVGKYVSPLWFDDEERIQILCK FSKLNSVCIESALIDNNFSYAYKRSKELFSGEYWLTFYQVGKYASPDWINDDSQLQVLIK YNKILVIHIDHALVNMDFTFAFQKSKELLRSTYWATVFQVCKFINPNWIDSEVPTEYLIL ETRIYTQAVTAALVHDDFDTAQKLCAAH--ELPWTAYFQVGKYVSPS----RDMDELVAL QMEILSELLQYSPIDQIEIIATQWSALEVELSIRDLSTDTSISNDSNQNSLNEVSHTMAA QLGIVSKLLHICPEKEYEVITSQWSGLELELSTRNLISDKYSLENSNDNFMSDVSTNVGN QMGILGKLLEICPLEEVEIVTSQWSTLELELSARDLVRDKYALEANKGGFAREIFHNVTS QMEVLAELLNVCPVEEIEIITSHWSGLELELSARDLVKDKYSLAS--------------- QMSILGRLLEVCPLEEVEIVTSQWSTLELELSARDLVKDKYALDGNDGGIAREIFHNVTN QMSILGQLLQICPLEEVEIVTSQWSTLELELSARDLVRDKYALDGNGGGIAREIFHNVTS ------------------------------------------------------------ QMSILGRLLEVCPLEEVEIVTSQWSTLELELSARDLVRDKYALDGNGGGIAKEIFHSVTN ------------------------------------------------------------ QMEVLSRLLHICPVEDVEAVVSTWSGLELELSTRTDVRDVYSLSNTNKEIVQQVSSSVSN ------------------------------------------------------------ QREILSLTILNLQKENSKVVLAQWMSLNDKIQRHSHSKKHLENIGTESKTTNNASEKLSN QLEVLGKLLHICPEDEIEAVVSQWSGLELELSTRDLINDQYSLSNGTNHIVEEVSASVSN QREILSKTLKYSKPDNSRLILKQWESINSQIEDWYAVPERMATLASDSNTTTQASDKLSN QREILSLTILNLQKENSKVVLAQWLSLNAKIQRHSNSKKHLENIGTESKTTNNASEKLSN QRQILSLTLQRLDGDHSRVILDQWNKVNAKLEENSKSDSAWSL-GQDSHSTNKAGEKISN QREILSLTIATLSGENSKIVINQWQSLNDKIQRVSYSTKHLENIGNDSKTTNNASEKISN QREILSSTLKLMKPDNSRLIIGQLRHVNQEIHRWYAVESTRNQIQKNSLSRAQAGEKLSN QREILLRTIQIIQPDNSKVILSQWERVNSQIEEHYTMTDNLGYMANETATTNKTSEKLSN QREILSTALIYCRSGNSKLLLRQWEIVNDQIDMYYSTPSSVQQETNNANTTHQTSEKISK QLELLGDLLSVCPADGLDIVVSQWSGAELELSTRNLIDDKYSIENGNINLLNDVSNSFTN KLETLSTALAKCPPEHLSAVLHAWRDVEEMMV---SLPESRESVVSVSREAGRKRDQLSS F----------------------------------------------------------- F-----------------------------MTFKLFKGSKGQEKPLVTL----------- F----------------------------------------------------------- ------------------------------------------------------------ F----------------------------------------------------------- I----------------------------------------------------------- ------------------------------------------------------------ F----------------------------------------------------------- ------------------------------------------------------------ FMHTTLPHAGPRAGPLPGPPVATGVLGGSQIRPMVQKGTHKNNDSFPSTAHTSMVEVKNT ------------------------------------MSNSRGSVVDVTFSTREPDVIQRA L----------------------------------------------------------- F----------------------------------------------------------M L----------------------------------------------------------- L----------------------------------------------------------- L----------------------------------------------------------- L----------------------------------------------------------- L----------------------------------------------------------- L----------------------------------------------------------- L----------------------------------------------------------- F----------------------------------------------------------- M----------------------------------------------------------- ----------------------MIHLIRNLFICVVEVMSIGSSSVTKFISDYATVL---- ------------------DGENVSHLFEQNDENLNKVSSLSLQQIRQRLNYKDVGS---- -------------MKVPSVIQIQFVALRRLLAETKEQFCFAIKNKLRSIFGWIMSL---- --------------MFKAVLEVQIKWLFMLVKEIKHLVFRTIHNVKQHLTNFLFSL---- -------------MKMPSIIQIQFVALKRLLVETKEQMCFAVKSIFQRVFAWVMSL---- -------------MKVPSIIHIQLIALRRLVVETREQFCFAAKNMFQRIFGWIMSL---- ------------------------------------------------------------ -------------MKVPSIIHIQLVALRRLLVETKEQICFAVRSVFQKIFAWVMSL---- ------------------------------------------------------------ EAATAAGGAQKQADQVIQLEWHDPIEEAAQELDAARVAANSEPTLRARVKRLVRGEWKQT FTLKAEDQDTEHPQAPDPTAKRTKKGPQLPNIWKREDVKCYLDHQKKQTYQYLLSL---- ----------------------------------MSSGPFYRSYSFNALWALVFKF---- IKTMGSKSRVEMVEKELEQSKERLKPKKPAFPNLLNRSSVKEYVHAQKLRIWSFVL---- --------------------------------------------MSSKVTSLVFTF---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MVETTSTPFSSFSFKAIVDLVLYF---- --------------------------------MQPWLQNVGNINTPKSLFIQVMIFSFSC -----------MTTISNKWHTTLTDRIYHPIINFKHSIYGQFNVQKQNLFIWIINL---- -----------------------------------------------MTVLSLPSF---- -------FYYCKSFYYINVITTSIQKML--IFAL-----------RTGP----------- -------YPF--SRLFAW-----LQMFM--VRIL-----------RMGP----------- -------SLF--SWLYRN-----IQKFL--IKVL-----------SVGP----------- -------PIF--VWFHKK-----TQLLL--IKIL-----------SVAQ----------- -------SLF--SWFYVN-----LQNIL--IKAL-----------RVGP----------- -------SLF--SWLYVN-----IQNLL--IEVL-----------SVGP----------- ------------------------------------------------------------ -------SLF--SWLYIT-----VQNLL--IKAL-----------SVGP----------- ------------------------------------------------------------ YRNRPKISHILFQFGLLRMVVNFVQNLL--LKIL-----------QMGP----------- -------PLI--SWLITL-----LQDFL--LDIL-----------RAGP----------- -------PLF--AYFVGF-----VEDFV--ISII-----------KTGP----------- -------NMAIVRWILIQ-----IQMIL--TNIL-----------RVGP----------- -------PLF--TYAIEL-----VKDFI--VSMM-----------RTSP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------PLF--SYLFGF-----FQDFC--IEVM-----------KTGP----------- ISNLADNSFV--RYISTI-----FKDFL--INML-----------RTGP----------- -------WLV--SWLNRQ-----LQSIM--INII-----------KTGR----------- -------PLM--QYARNL-----FQDLL--VRVL-----------RTGP----------- -VPAHVAFIMDGNRRFAKSKDIPLRK-GHEAGGETLLTLVYICKTL-GVKCISAYAFSIE -VPRHLSFIMDGNRRYAKKLDQPVKE-GHRAGGATLIDILHICRRL-NVSSVSAYAFSIE -VPEHVSFIMDGNRRYAKSRKLPVKK-GHEAGGLTLLTLLYICKRL-GVRCVSAYAFSIE -VPEHVSFIMDGNRRYAKSRNLPLNK-GHEAGGVTLLTLAYICKKI-GVKCVSAYAFSIE -VPEHVSFIMDGNRRYAKSRRLPVKK-GHEAGGLTLLTLLYICKRL-GVKCVSAYAFSIE -VPEHVSFIMDGNRRYAKSRRLPVKK-GHEAGGLTLLTLLYICKRL-GVKCVSAYAFSIE ------------------------------------------------------------ -VPEHVSFIMDGNRRYAKARRLPVKK-GHEAGGLTLLTLLYICKRL-GVKCVSAYAFSIE ------------------------------------------------------------ -LPQHVSFIMDGNRRYAKSMNLPLKL-GHEAGSVALMRTLHTCKRA-GIEAVSAYAFSIE -LPNHISFIMDGNRRYAKSLGMPIIK-GHEAGAITLLRMLYNCKKL-GIKTTSAYAFSIE -IPKHVAMIMDGNRTYAKKHRLPLKE-GHFAGANALVKVLEVCYKV-GIEQVTIYAFSLE -LPPHVSFIMDGNRRYAKSLSVPIKA-GHEAGALTLLNLLVTCRNL-GIKTVSAYAFSIE -IPKHIGLIMDGNRRYAKSKDMELKD-GHNAGADSLIQVLNTCYKL-GILHVTVYAFSIE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -IPNHVALIMDGNRRYSKAKNLPLKE-GHISGAETLLTVLDVCYRL-GIDHVTIYAFSIE -NPKHIAFIMDGNRRFSKRNHMKLAD-GHSKGAEVLFEVLTTAYQL-DISHVTVYAFSIE -VPEHISFIMDGNRTYAKNLNMPIKK-GHEAGGITLLSLVYACKRM-GVRCVSAYAFSIE -VPRHVAFIMDGNRRFAKTNNLELRE-GHVAGTELLLKLLEVCFRM-GINTVTIYAFSIE NFNRPREEVETLMNLFGDKLDEFAQKAN----------------DYKDPLYG-SSLRIVG NFNRSPQEVATLMELLGYYIDQFTERAT----------------NAKDELYG-IRLRVVG NFNRPKEEVDTLMNLFTVKLDEFAKRAN----------------DYKDPLYG-SKIRIVG NFNRSKEEVDTLMELFSAKLDEFAKRAI----------------DYRDPLYG-SRLKVVG NFNRPKEEVDTLMNLFTVKLDEFAKRAK----------------DYKDPLYG-SKIRIVG NFSRPKEEVDTLMNLFTVKLDEFAKRAN----------------DYKDRLYG-SKIRIVG ------------------------------------------------------------ NFNRPKEEVDTLMNLFTVKLDEFAKRAN----------------DYKDPLYG-SKIRIVG -----------------------------------------------------SRLXIVG NFNRPKEEIDTLTEMLSRRLQDFANRAT----------------NLKDRMYG-ARLLVVG NFNRPKEEVDTLTRLLAEKLDEIAVKAQ----------------DVKDELYG-SSFKVVG NFNRSKEEVDTLFALLRDKLKVMSEHE-----------------DSYAR-YNKVRIRIIG NFNRPQEEVDTLTGLLAEKLDEVARRAC----------------DRESELYG-LRLRVVG NFNRSKEEVDTLFALLRDRLKFISEKE-----------------ESYAR-FNNIRIKIIG ----------------------MSEHE-----------------DLYAR-YNKVRIRIIG ---------------------MLSEYD-----------------DSYAK-YNKVAIKIIG ---------------------MISEHE-----------------DSYAR-YNKVRIRIIG ------------------------------------------------------------ NFNRSQEEVDTLFGLLRDKITQISEHE-----------------DSYAR-FNNVRIRIIG NFNRPQDEVDTLFGLLRDKLAILADNE-----------------TSFAQ-VNHVKIKIIG NFNRPKDEVDTLNNLFADKLDEFAIRAK----------------DFQDPLYG-AKIKIVG NFNRPKVETDALFDLIRNNIVVLGSKD-----------------EMAER-YG-LAIKILG DRSLISPELRERIENVEKLT-----ENS-EKFILYICFPYTSRNDIFQTVTKVTDKYVQS DLSLLSEELLKKIRNAEKLT-----RDG-QEFVLYLALPYTSRNDIAHSMQVTTDKCINS DQSLLSAGMREKIAKVEEIT-----KLG-DDFTLYICFPYTSRNDMLHTIQGSVQDCLQN DHSLISKELRDKIYKVEQLT-----TDG-SDFTFYVCFPYTARNDIYHTMYNFIANPEPE DQSLLSPEMRKKIKKVEEIT-----QDG-DDFTLFICFPYTSRNDMLHTIRDSVEDHLEN DRSLLSPEMRERIANVEDIT-----KGG-DDFTLYICFPYTSRNDMLHSIRDSVRDQLED ------------------------------------------------------------ DQSLLSPEMRKRIEKVEDIT-----KNG-DDFTLYICFPYTSRNDMLHTIRDSVQDLLEN DHSLISEEMREKIKRVEEMT-----NDG-DEFTLFICFPYTSRNDIWHATQTSVEECVQQ DRALLSPELNDKITYIEDMT-----KHN-TAFTVYICLPYTTRNDIYHAMFDLVRLCQAG DRSLISRELNDKITNVERMTAVNDVDEE-KTSLLYICFPYTSRNDIYHAMYNTVERVKYH NRSFIPEDILKDLENVEETT-----KDFGSKKTLNVCFPYTARDEITYAIKTIASKRVSG ERSRISKSLNDRISRVERLT-----DEG-DIMTLYICFPYTSRNDIYHAIYNCAESCKYL NRTMIPSDILKDLEDIEERT-----KHVSSAKVLNVCFPYTSRDDIVHSIQSIAEKVESK NRSFIPEDILKDLENVEETT-----KDFGSKKTLNVCFPYTARDEITYAVKSIASKRVSG NREYIPEDILKDLVAIEDST-----KNNVSKKVLNVCFSYTARDEMTHAIKSIMQKRIDG NRSYIPSDILKDLENIEEIT-----KDHSSKKTLNVCFPYTARDEITYAVKRIAEKRVNG ------------------------------------------------------------ NRTYIPPDILADLERAELVT-----KDSKHNRTLNVCFPYTSRDDIAISMKNIAEKVQVQ NRSYIPDDILSQLEEIERKT-----NKPDSHKVLNVCFPYTSRDDITEAMRKVVSSLVSS DATMIGDEMKRRIKRVEKIT-----QDG-EDFILYICYPYTSRNDIYHAVQRSVEQTLNN NRDLIPEDILELIVRVEETT-----KDN-KRGTLNICFPYTSRDDIAQAIQKVVTDVFAD ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------N----------------------------IIDSNLSINEFT -------------------N-------------------------------EDITEQALT -------------------K-----------------------------SQSKIDIKKFT -------------------K----------------------------EKSEELTIEKFT -------------------K------------------------------SPRINIRKFT -------------------K-----------------------------LHSRINIKKFT ------------------------------------------------------------ -------------------K-----------------------------SPSRINIKKFT -------------------S----------------------------LEPRALTVEEFN -------------------A----------------------------LDSKDISTEMLT -------------------G----------------------------MSTESISVESLT -------------------E---------------------------LNDRNKITTKTIE -------------------N----------------------------SPVSDIDETYLT -------------------E---------------------------IESNQHITLETLT -------------------E---------------------------LNNRNKITTKTIE -------------------K---------------------------IQHRDEIGISTIE -------------------E---------------------------ITSRDEITTKTIE ------------------------------------------------------------ -------------------E---------------------------IPSKDEITLQTLK -------------------D----------------------------LQRQDLNEDVLQ -------------------E----------------------------ISKDEITIKHFT -------------------T------KQAPPPKSFGPPSSTS-----RPSPLHVTEKMLE KSMHFKE--YSDNCDILIRTSGHKRLSDFMLWQVNE-HA--------------------- DNMYFEQ--YSNKCDLLIRTSGHTRLSDYMLWQVHE-GS--------------------- SKMYMDF--YSNKCELLIRTSGHRRLSDYMLWQVHE-NA--------------------- SQMYLRE--FSNKCDLLIRTSGHNRFSDYMLWQTHE-NG--------------------- NKMYMGF--HSNKCELLIRTSGHRRLSDYMLWQVHE-NA--------------------- NKMYMDF--YSNKCELLIRTSGHRRLSDYMLWQVHE-NS--------------------- ------------------------------------------------------------ NKMYMDF--YSNKCELLIRTSGHRRLSDYMLWQVHE-NA--------------------- KXXYLND--YSHKCDLLIRTSGHLRLSDYMSWQVHE-SG--------------------- NAMYLGA--NSNRADILVRTSGHTRLSDYMLWQVHE-QS--------------------- DAMYFDE--FSNKCDLLIRTSGHTRLSDYMLWQSHE-NG--------------------- KNFYFGD--DVPPLDILIRTSGHTRLSDFLLWQCTT-EC--------------------- NNMFMKE--QSNKCDLLIRTSGHTRLSDYMLWQAHE-NG--------------------- NNMYMGP--NTPPLDILIRTSGHTRLSDFMLWQCNY-NC--------------------- KNFYFGD--DVPPLDILIRTSGHTRLSDFLLWQCTT-EC--------------------- SNFYFDD--NVPPLDILIRTSGHTRLSDFLLWQCST-SC--------------------- ENFYFGG--DVPPLDILIRTSGHTRLSDFLLWQCNT-EC--------------------- ------------------------------------------------------------ ENNYFGA--DVPELDILIRTSGHTRLSDFMLWQANF-NC--------------------- HQMYMDP--NTPQLDILIRTSGHTRLSDFMLWQCTA-NC--------------------- ENMYLES--FSNRCDLLVRTSGHKRLSDYMLWQTHE-NA--------------------- KAM-YTG--ESPPLDIMIRTSGVTRLSDFMLWQSHK-NC--------------------- ------------------------TMEFSTSLWP-------------------------- ------------------------IIEFVDCLWP-------------------------- ------------------------TIEFSDTLWP-------------------------- ------------------------TIEFCNTFWP-------------------------- ------------------------TIEFSDTLWP-------------------------- ------------------------TIEFSDTLWP-------------------------- ------------------------------------------------------------ ------------------------TIEFSDTLWP-------------------------- ------------------------DIKFSPTSWP-------------------------- ------------------------YIEFSNCMWP-------------------------- ------------------------MIEFSTTLWP-------------------------- ------------------------TIEFPDVLWP-------------------------- ------------------------VIEFSNTLWP-------------------------- ------------------------MIEFVDTLWP-------------------------- ------------------------TIEFPDVLWP-------------------------- ------------------------TIEFPETLWP-------------------------- ------------------------TIEFPDVLWP-------------------------- ------------------------------------------------------------ ------------------------MIEFVDTLWP-------------------------- ------------------------DIEFVETLWP-------------------------- ------------------------TIDFHSGLWP-------------------------- ------------------------TLEFVDTLWP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------QFNFFQMYL------------- --------------------------------------DFNFWRLYW------------- --------------------------------------NFSFLAMYL------------- --------------------------------------DFGFMGMYM------------- --------------------------------------NFSFFAMYL------------- --------------------------------------NFSFFAMYL------------- ------------------------------------------------------------ --------------------------------------NFSFFAMYL------------- --------------------------------------DFKFFQLYL------------- --------------------------------------DFTFRTFFT------------- --------------------------------------SYTFLEFYL------------- --------------------------------------DFGFISIMS------------- --------------------------------------DFDFFEFFK------------- --------------------------------------EFRSWDIMS------------- --------------------------------------DFGFISIMS------------- --------------------------------------DFGFVSMIS------------- --------------------------------------DFGFVSIIS------------- ------------------------------------------------------------ --------------------------------------DFKFFSITS------------- --------------------------------------EFGFFQFFQ------------- --------------------------------------DFTFIKLYL------------- --------------------------------------DFGVRELYR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------IIL ---------------------------------------------------------IML ---------------------------------------------------------MIL ---------------------------------------------------------IIL ---------------------------------------------------------MIL ---------------------------------------------------------MIL ------------------------------------------------------------ ---------------------------------------------------------MIL ---------------------------------------------------------MIL ---------------------------------------------------------ILL ---------------------------------------------------------VLV ---------------------------------------------------------ILF ---------------------------------------------------------MLL ---------------------------------------------------------III ---------------------------------------------------------ILF ---------------------------------------------------------VLF ---------------------------------------------------------ILF ------------------------------------------------------------ ---------------------------------------------------------VIL ---------------------------------------------------------ILV ---------------------------------------------------------KLI ---------------------------------------------------------LLL R----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- ------------------------------------------------------------ K----------------------------------------------------------- N----------------------------------------------------------- K----------------------------------------------------------- R----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- ------------------------------------------------------------ K----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- K----------------------------------------------------------- ----------------------------------------------WS---M-------- ----------------------------------------------WS---F-------- ----------------------------------------------WS---F-------- ----------------------------------------------WS---F-------- ----------------------------------------------WS---F-------- ----------------------------------------------WS---F-------- ------------------------------------------------------------ ----------------------------------------------WS---F-------- ----------------------------------------------WS---F-------- ----------------------------------------------WS---F-------- ----------------------------------------------WS---F-------- ----------------------------------------------WS---Y-------- ----------------------------------------------WS---F-------- ----------------------------------------------WS---Y-------- ----------------------------------------------WS---Y-------- ----------------------------------------------WS---Y-------- ----------------------------------------------WS---Y-------- ------------------------------------------------------------ ----------------------------------------------WS---Y-------- ----------------------------------------------WG------------ ----------------------------------------------LS---L-------- ----------------------------------------------WS---Y-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------FK---------------------------------------------------- ------YQTW-------------------------------------------------- ------FC---------------------------------------------------- ------FK---------------------------------------------------- ------FS---------------------------------------------------- ------FC---------------------------------------------------- ------------------------------------------------------------ ------FS---------------------------------------------------- ------FT---------------------------------------------------- ------VTALH------------------------------------------------- ------------------------------------------------------------ ------YR---------------------------------------------------- ------FT---------------------------------------------------- ------YR---------------------------------------------------- ------YR---------------------------------------------------- ------YK---------------------------------------------------- ------YR---------------------------------------------------- ------------------------------------------------------------ ------YK---------------------------------------------------- ------------------------------------------------------------ ------YM---------------------------------------------------- ------VK---------------------------------------------------- -------------------MFQI----YNMNNVSKHSKFGSKLYKPYKTILKYIFSERLP -------------------QNASQLPDPVRTRTRVFPKISGALPIETLKRTKRVALDSLP -------------------TIQR----YNERNHSLFERVYEGVPSILKRKKTSMSLYQFP -------------------TIQK------FNEMNFSLKTIWYEGPNSKIQNRYTKLEELP -------------------TIQK----YNEKNHSLFEKIHESVPSIFKKKKTAMSLYNFP -------------------TIQR----YNERNHSLFEKMYEGLPSILKRKKTPMSLYQFP ------------------------------------------------------------ -------------------TIQR----YNEKNRSLFEKVYEGVPSILKRKKPSMPLYQFP -------------------TIQR-------YIFHGSKXSQSKPAFWNRKXSSKYSLEDLP -------------------EARK--------QERLRRKLGTYARSLLARRARPVRLEALP -------------------FTSLQRFQTSGFSARGQMFNFVREALFSKGHGTPIPLEELP -------------------TIQI--------EEEAIRGKE----PRVQEVIPPVLLKELP -------------------SVRR---KQLNNVSLRSQTLSFFKRTLFPFKRKQVSYEDLP -------------------TLQL--------EQQRIMSNK----KREDQKAMTDILKELP -------------------TIQI--------EEEAIRGKE----PRVQEVIPPVLLKELP -------------------TLQL--------EEENMCGTQ----FEIQESIAPVLLKELL -------------------TIQI--------EEEAIRGKE----PHIQDVVPPVLLRDLP ------------------------------------------------------------ -------------------TLQI--------QQFEAQGIK----DDEDRSRKMKKLMELP -------------------WSKT-------------------ALAGWNTGRAKVYVYELP -------------------TVQN----YYETTFLSSEQVLRKKAEYYNKWRGNINLSSLP -------------------TLELQRDDLIQTTKVNNSTKNDYVGNYDEEVSSHASALTKI D----------------------------------------------------------- A----------------------------------------------------------- D----------------------------------------------------------- E----------------------------------------------------------- N----------------------------------------------------------- N----------------------------------------------------------- ------------------------------------------------------------ N----------------------------------------------------------- A----------------------------------------------------------- P----------------------------------------------------------- P----------------------------------------------------------- N----------------------------------------------------------- E----------------------------------------------------------- P----------------------------------------------------------- N----------------------------------------------------------- K----------------------------------------------------------- H----------------------------------------------------------- ------------------------------------------------------------ P----------------------------------------------------------- P----------------------------------------------------------- E----------------------------------------------------------- S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------PPMAVPVTNR---------------------------------- ----------------APLAVSVDRK---------------------------------- ----------------PPISVSITGED--------------------------------- ----------------PPVHVSVLGERE-------------------------------- ----------------PPISVSVTGDE--------------------------------- ----------------PPISVSITGEE--------------------------------- ------------------------------------------------------------ ----------------PPLSVSVTGEE--------------------------------- ----------------APVAVSITGERDPS------------------------------ ----------------PPQAISVTDR---------------------------------- ----------------PPVAVSVAERA--------------------------------- ----------------PPPATSVI------------------------------------ ----------------PPQAVSVVQRN--------------------------------- ----------------HPPFASIT-QH--------------------------------- ----------------PPPATSVI------------------------------------ ----------------PPPTISVS-QK--------------------------------- ----------------PPPATSVTIQK--------------------------------- ------------------------------------------------------------ ----------------PPPIASVS-QR--------------------------------- ----------------APPLVSVIGR---------------------------------- ----------------PPPTISIVGRKS-------------------------------- ----------------SVEKAVVHDEGIVEGICID------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MEHSAAVVVATLILGIFVVKWFAAPKEHPSAQRLPNTQ ----------------------ADQSFTLFIILAIAGYIAVKWFLNNEQHPSIQINGFSS ----------------------MENSKLLITLVLVFGGIFLRKFFQSNQHPSAQRLSATG ----------------------MVSSNITIVATLVIGVLLLKWFFQSDQHPSAQQSTQQQ ----------------------MEDSRLLITLILVFGVIFLKKFFQSNQHPSAQRLSATG ----------------------MEDSRLLITLVLVFGVIFLRKFFQSNQHPSAQRLSTTG ----------------------MEDSRLLITLVLVFGVIFLRKFFQSNQHPSAQRLSATG ----------------------MEDSRLLITLVLVFGVIFLKKFFQSNQHPSAQRLSATG ------------------------------------------------------------ ----------------------MDQSSALFLALLLVLFVLVKWFIKTESHPSAQHTVDTG ----------------------MDQSSFTFLAVLIVSFLFLKWFTKSDSHPSVQHATVNG ----------------------MDG--------------------VPNTTQNEFTAQSTG ----------------------MDSYTITFLVIILTSFVLAKWFLQSESHPSAQRASNAS ----------------------MDNSTIVFIAVLGVAFIFLRWLIAPIPPPNELNALANS ----------------------MDSSTILFIGAVAVAFIFLKWMVSPIPQQNEFNDQSTG ----------------------MDSTTILFIVTIAVAFIFLRWMILPIPQDSEFPLPNTG ----------------------MDSSTIAFVGTALVVFVFLKWMISPIPQPHEFTGSATG ----------------------MDTSTIVFILVLLVAFLFLRWLISPIPQPDEFNVHTS- ----------------------MDSSTVIFVATLAIAFIFLRWLIAPIPQSNEFNAEAAG ----------------------METSTVVFFATIVAGFLILRWLISPIPDPLEEAAAAHA ----------------------MDFSTITFVMTLVIGFILIKWFFQGDEHPSTQNNNSQR ------------------------------------------------------------ LPSSSNNQQRTAGSSTSRRNITPEMIETVRNVIPALHPEQIRYDLESTGSVEQTMERYFN QSDSATASGTAASSNRIRRRVNDDMIEVVQSLAPHLHPEQIRYDLEQTGSVETTVERYLS VNTHGRPQGPTHGALRAGRPVTAQMVETVQNLAPNLHPEQIRYSLENTGSVEETVERYLH QSSTARNTRRPNSGGSSGSPVTEDMIQTVQNLAPDLHVEQIKLSLQETGSVETTVERYLN VNAHGRPQGSTQNALRTGRPVTTQMVETVQNLAPNLHPEQIRYSLENTGSVEETVERYLR VNAHGRPQGPTQSALRTNRPVTTQMVETVQNLAPNLHPEQIRYSLENTGSVEETVEKYLR VNAHGRPHAPTQSSLRTGRPVTVQMVETVQNLAPNLHPEQIRYSLENTGTVEETVERYLR VNAHGGPQGPTQNALRTGRPVTAQMVETVQNLAPNLHPEQIRYSLENTGSVEETVERYLR ------------------------------------------------------------ LSSTGAAGGRAQGTGRRRRPVNDDMIEVVQALAPHLHSEQIRYDLERSGSVEATVERYLR T--TGNPVVSASAQRRARRRVTPDMIEVVQSLAPNLHVAQIKYDLERTGSVEETVEKYLR STTSSNAHQNRDTHSNSRRAVSESMIEVVQSIAPMLTVEQIRYDLETTGNVEATVNRFME SGTTARPSRRADAARRPKREVTEDMIEVVQSLAPTLHREQIKYSLEQTGSVEETVEKFLR VNNSNRPNNSNNSNSRGRREPSDDMIEVVQTIAPQLTRGQIRMDLERSGSVEVTMERYME STTSSNAQHNRDTHSNSRRAVTESMIEVVQSIAPMLTVEQIRYDLENTGNVEATVNRFME SSASSRVSGSGSGLGTTRRPVTDSMIEVVQTIAPSLTVEQIRYDLEATGSVEVTIDKYME SNTSSSSSSSSSTTTRGRRPVTDSMIEVVQSIAPMLTVEQIRYDLENTGNVEATVNRFME ---VGQPENHTNNHVRRRREVTDSMVEVVRAIAPQLTEQQIRFSLERTGSVEATVDEYME NTSTGQESNNSSNASRSRRPVTDSMVEVVQTIAPGLTRDQIVFDLSNTGSVELTINRYME TQRDGRRPTPST---RSRRPVTDSMIDVVQAIAPQLTRGQIRMDLERSGSVEVTIDRFME QSNQNNEQQRQPRSNRFKRRVTDDMIEVVQSLAPSLHVEQIRYSLTQTGSVEETVEKFLR ------------------------------------------------------------ GESFPFPPGYTPARESSANGQHPSDIRKRSNIRPDNLLSKFNVDMSSDMSIKELEIDERK GRDMPFPPDYVPESETGGNSSNSTDPRKRSNIKADNLLKKFNVDPQSNLNPNDLSIEERK GDEFSFPPGFEPSRAPMGANAAFNDPRKKNMICAENLLDKFHVDPNSQVSFKDLDIEERK GQTFPYPANFSPSSVNNLNIANPTDPRKVNLIKSENLLTKYHVDLNDDAKYRELDLDERK GDEFSFPPGFEPSRAPMGANAAFNDPRKKNMICAENLLDKFHVDLNSNLSFKDLDIEERK GDEFSFPPGFEPSRAAIGANGAFNDPRKKNMICAENLLDKFHVNPNSHMNFEDLDIEERK GDEFSFPPGFEPSRAPMGANAAFNDPRKKNMICAENLLDKFHVDPNSHLNFKGLDIEERK GDELSFPPGFEPSRAPMGANAAFNDPRKKNMICAENLLDKFHVDPNSNLSFKDLDIEERK ------------------------------------------------------------ GEDFPFPPGYTAPIPPESPQQDSSDPRKRSNIRADDLLQKYDVDPASAVEFHELDMDARK GDAFLYPPGYQPEQNSSNSNSPPSDPRKRDNIKADNLLAKYNVDPNDGEEYAELTIEERK LGDLPFPPGYVRPQQPPTP---SEEPKKQEVIRSVNLLEKYNIDAKNPKSDHNSLLHQRR GDDIPFPPGFVPETPSVAMQQNSSDPRKRSNIRPDNLLTKYKIDIDSDVDFSSLNIEERK TGSLPFPPGESAATQSYQSDISSQATKK----EPENLIDKYDLKSKSSKEERSSLLNKKR LGDLPFPPGYVRPQQPSS----SEEPKKQEVFRSVNLLEKYNIDAKNPKNDHNSLLHQRR TGTLPFPPGYVAPRAEPALASNVNQKKEKSVSETIDLIKRYGIDINNPVSGNEDIFKNRR LGDLPFPPGYVAPPPPPPPQTTEHELRKEILLRSINLLEKYHIDIDNPNTSNDNSLQQKR NSSLPFPPGHDAEDNAHNVAPE----------GAKTLLEKYNIEVLQDESERSALLQRRR LGNLPYPP--NSARGTNSASSNHSQSQSQASSATEATMES-NSSPKADKSERSVSLHRRK EGTLPMPENQNDEETEGNGQGNSNQSEGGSGIKPANLIERYGLESKATNQDKIDLLSSRR GEEFPFPPGYRASPSNDDNDTASSDPRKKNNIKPDNLLSKFNVALTSDINFKDLDMEERK ------------------------------------------------------------ KLLVWEARKNMEKRLETDT--------------MSKVARQLKFLNKISSTTTDAQVILSP RLMVWQARKSMELKVENSE--------------MSGIVKQQKFLNKISATTVKPQIILDV KLLVWQARKNMETKLQNDK--------------MSKVTQQLNFLNKISATTKLPQILIDS RYMIWKARRSMEKRIETDP----------------------------------------- RLLVWQARKNLETKLQSDK--------------MSKVAQQLKFLNKISATTRLPQILVDP KLLVWQARKNLETKLQNDK--------------MSKVTEQLKFLNKISSTTNLPQILIDP KLLVWQARKNLETKLQDDK--------------MSKVTQQLKFLNKISATTKLPQILVDP KLLVWQARKNLETKLQNDK--------------MSKVTQQLKFLNKISATTKLPQILVDP -------------------ADSYNVQFFLRSSTMPNIPKQLNFLNRISYNTPKAHVRLDP RFMVWRARKRMEANLQK----------------MSNVKKQLAFLNRICG-TAKPQVLVDT KFLVWQARKRMEQRLKNDQ--------------MSRVVKQLKFLNRISFATKKPQVVADP QEMILGARKRLAAQLSNEL----------------------------------------- TFLVWQARKDMAKTLEQDE--------------MSRVSRQLKFLNKISSTTLEPQILLNA EEMILQARKRLASQLQNEVMSKTSNCAMFKNLPSSRILKQITRLNNIAG-TPETAFKFNP QEMILGARKRLAAQLSNEL-----MFITSKNKYNKKIENAIKKINRLTG-NPENSFKFDA NEMIVNARKRLAAQLQNQK-MSLRSLGTPTKKYSPRLLKQIDRVNKLRG-TPETSYKFDA EEMILNARRRLAAQLRNDL----------------------------------------- EEMILRARRRLEKSLANDV----MSASMFKNLPSSKILKQVARLN-LIAGTPENAFKLGP QEMIVAARRRLEALLKNELMAKLGSCAMFKGLPSSRILKQITRLNAIAG-TSESAYKFDA EEMILNARKRLAAQLSNEIMAKVGSTAMFKGLPSSRTWKQAARLNQIAG-TPQTAYKFDP KYMIWQSRKAVEKKLNEDE----------------MSAKQISFLNKISFKTKKPQILIDS ---------------------------------MTGVDKQIFQLNKVVT---APGAYKLP ---------GKYQRLSLTFQTKN---HNGHMGARKFWKDYLPTIQFYNPQLRIDVTRIKN ---------SKYSALNVKFQYQN---FNGHMGARKFWHEFLPSLQFYNPALPINVTRIRN ---------KKYSGLRLTFQTKN---HNGHMGARVFWHDYLPTLQFYNPEIKFDVIRIKN ------------------------------------------------------------ ---------KKYSGLRLTFQTKN---HNGHMGARVFWHNYLPTLQFYNPRMKFDVIRIKN ---------KKYSGLRLTFQTKN---HNGHMGARVFWHNYLPTLQFYNPRIKFDVVRIKN ---------KKYSGLRLTFQTKN---HNGHMGARVFWHNYLPTLQFYNPEMKFDVMRIKN ---------KKYSGLRLTFQTKN---HNGHMGARVFWHNYLPTLQFYNPRLKFDVIRIKN ---------SRYSGLKSVFQYEN---HNGQMGARKFWNQYLPTSKFYNPELQMDVLRIRN ---------TKVSGLKLTFQAQS---HNGHMGARKLWREHLPTLQFYNPGLDIQVHRVAN ---------EKYAALNLTFQWQN---HNGHMGARKFWREFLPTLQFYNPDLKIQVTRIKN ------------------------------------------------------------ ---------NTYSGINLTFQYQN---HNGHMGARKFWQECLPTLQFYNPSMEFKVTRVKN ----------KYTKLELFLIKQN--VSGSAIGLKKFWRNNLPTLKFHNEDVNFVLTRINT ---------ERFKEIELFVYGQRPITYKPAWGIKLFWKDNLPTLRYHNPDIQFTVTNITV ---------SKIKEVELFVYRQKPIVFQPAKGLKSFLKDSLPTLRYHNPDIQFTVTNIKA ------------------------------------------------------------ ----------QIKKLELILISKN--VFKPAAGLKHFWRRNLPVLKFHNEHVDFVTTRVRA ---------SKYTKIELFLQQKN--IHGPAVGLKKFWRQNLPTLKFHNDDIQFSLTRIQA ----------KYTKIELLLIQKN--VFAPAFGLRRFWRQNLPTLKFHNDDVDFVLTRIAT ---------AKYSGLRLTFQYQN---HNGHMGARKFWHEYLPTLKFYNPALQVDVLRVRN ---------DNVSALKLRFKD-----SGNRSQTKLFWTHSLPTLQFWNPSVAMSVSRVQA ESKT-------------------------VSVPCTLQAIGTDGKVVEEIDMSNKHAPEIL DDKK-------------------------VDVPCILEAIGSDGKVVAEVSMKHKHSSEIM EDKQ-------------------------KSVPCKLEILSQEGTVTETIDMRNKMHDVIM ------------------------------------------------------------ EDKQ-------------------------KSVPCKLEILSHEGSVVETIDMRNKMHEDIM EDKQ-------------------------KSVPCKLEILCQEGSVTETIDMRNKMHEDIM EDKQ-------------------------KSVPCMLEVLSHEGSVVETIDMRNKMHEDIM EDKQ-------------------------KSVPCKLEILSHEGSIVETIDMRNKMHEDIM SNLR------------------------DATTPCYLEALDRDGKVIQTLQMKNKRSDTIL SDKK-------------------------QPVPCVLEVLGHDGNVLHRLDMAHKHSDTII DNNK------------------------DASVPCTLEIVSKDGSVVDQLDMKNKDQNAIM ------------------------------------------------------------ EDKK------------------------NASVPCSLEIIGKDGKVLETLDMRNKQQQEIM STKE-----------------------DISKCPSKI-VVYDNADKKYEIDCADRHTSDIL ENES-----------------------ELSKLPLKLKVHGTDQSSNFEINCSDKPPSKIL ELED-----------------------ELKKIPLKLNIKAHNESDSSSIECANQPPHWIL ------------------------------------------------------------ QTKE-----------------------EIAKVPSKIVIHGTDGSK-KDIDCLFTDHNDIL ETAA-----------------------EVAACPSKIVVHSVDPASKIEIDCKGKHSLVIL KTKE-----------------------DLAKCPTKIILHHADGSV-QELDCSNKHSNKIL NDKS------------------------NVRVPCKLEVISKDGEVLKTINMKNQKHTSIM PKEK--------------------------SVGPTVTITRTDGSE-ETISIASMFWEKMA QSLLQKLDHERVPE-----SQIISV----------------------------------- DEVLQKLEHKRVPQ-----EEIIKV----------------------------------- KDLLDKIEHKPLPE-----NEVIRA----------------------------------- ------------------------------------------------------------ KDLLDKIEHVPLPE-----NEIIRV----------------------------------- RDLLDKIEHIPLPE-----SEVMKV----------------------------------- KDLLNKIEHTPLPE-----NKIVRI----------------------------------- NDLLDKIEHVPLPE-----KEIIRV----------------------------------- DXFNQLFELEQIPN-----DQLIQLKRN-------------------------------- DELLSTVEHTPVPA-----EQQVRV----------------------------------- DELLSKLEHTRVPE-----RDLVKV----------------------------------- ------------------------------------------------------------ QELLAKVEHERVAE-----TDIVRL----------------------------------- AEVIKVTEASPVAE-----KEIPVI----------------------------------- SELVEITKARKLTE-----EELPKL----------------------------------- SELVKRTKARQMTA-----EEIPLI----------------------------------- ------------------------------------------------------------ KKLVDATKATPVDA-----ADIPVV----------------------------------- NELVEATKATNVPI-----EEIPVL----------------------------------- KELVALSEAKAVPK-----EEIPVVKHA-------------------------------- DRLLEEVEHKPVPT-----KDLIEI----------------------------------- ETIAEAAGATPVSAGEDKKMELAKKTHLRDVAFAQKVELHKQQEADREALELAAKEEAKA ---------------------------------------------GTQSA---------- ------------------------------------------------------------ ---------------------------------------------GFPIE---------- ------------------------------------------------------------ ---------------------------------------------GPQESII-------- ---------------------------------------------PSSLRSIH------- ---------------------------------------------GLQKVV--------- ---------------------------------------------GSQESTV-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AAPQQDNFI------ ---------------------------------------------PLRPVK--------- ---------------------------------------------ERTYKVKKW------ ------------------------------------------------------------ ---------------------------------------------AVPKNRLR------- ---------------------------------------------RPPQQKESWAT---- ---------------------------------------------GEEL----------- ------------------------------------------------------------ AAQKKKDAMIKARKEGRVYIEGEENEVKEAAVEVEQKVTEEVAEDGAKIEIKETEVKIET --LGHIFTPKHQKLVNQCYPSGRAPDKKPKSSETSYLIYYVNSRSSKLEKVSNYLIKRTN --MGFLFTPKHQKLVNQCYPPGRTPDKKPKGSETSYLLYYVNSRRPKLEKVSSYLVKRST --MRMMFTPKHQKLVNQCYPTGRTTDKKPKSSETSYLLYYVNSRRSKLEKVSTYLIKRST --HTNIFTPKHQRLVNQCYPTGRTTDKKPKSSETSYLLYYVNSRRSKLEKVSSYLIKRTS --MRMMFTPKHQKLVNQCYPTGRTTDKKPKSSETSYLLYYVNSRRSKLEKVSTYLIKRST --MRMMFTPKHQKLVNQCYPTGRTTDKKPKSSETSYLLYYVNSRRSKLEKVSTYLIKRSI ------------------------------------------------------------ -----MFTPKHQKLVNQCYPTGRTTDKKPKSSETSYLLYYVNSRRSKLEKVSTYLIKRST ------------------------------------------------------------ --MGLLFTPKHQKLVNQCYPTGRTPDKKPKSSETSYLLYYVNSRRTKLEKVSAYLVKRTA --MRLSFTPKHQKLVNQCYPTGRTPDKKPKSSETSYLLYYVNSRRTKLEKVSTYLMKKSA ---MNLFQHKHQKLILQCYPAGKAVDKKPNSSELSYLLYYASTRRVKLEKVINFLKDKTH --MRVLFTPKHQKLVNQCYPTGRTTDKKPKSSETSYLLYYVNSRRTKLEKVSNYLARKCN ---MPIFRPKHQKLILQCYPPGKGVDKKPNPSELSYLLYYASTRRVKLEKVVTFLDRKTT ---MNLFQHKHQKLILQCYPAGKAVDKKPNSSELSYLLYYASTRRVKLEKVINFLKDKTH ---MNIFHHKHQKLILQCYPAGKATDKKPNSSELSYLLYYASTRRVKLEKVSVFLREKTA ---MNLFQHKHQKLILQCYPAGKATDKKPNSSELSYLLYYASTRRVKLEKVINFIRDKTQ ---MRLLHAKHQKLILQCYPPGKSVDKKPNPSELSYLLYYASTRRVKLEKVIDFLAHKTK ---MHIFTAKHQKLILQVYPPGKAVDKRANPSELSYLLYYASTRRVKLEKVVTFLEAKTA ---MRVFHSKHQKLILQCYPAGKAPDKKPNSSELSYLLYYASTRRIKLEKVSVFLDRKTA --MRFIYTPKHQKLVNNCYPNGRTTDKKPKSSETAYLLYYVNSRRSKLEKVSSYMVKRSS KNAPGIPKPRHQRLVLQCYPDGQAADKKPNPSELSYLLFYVNHRRVKLEKVGPFLENKCY TDLSRRRVGNVCVTLELMAKIVDHCKENLNVFVKEFLTLMNMVLTNNDVTVIELLEITFG TDLNRRRSGNVSVTLELLAKIVENCNENMNIFIKDFIHIMTLVLNNNDPTIVGLIERVLE SDLNHRRIGNIAVTLDLMNRIVLHCRENLNVFVKDFLYIMNKVLSNNDVALVELVELAFS SDMNRRRVGNVSVTLELMNKIVNSCKENLNLFIKDFFHIMNAVLSNNDVSIIELLELTFN SDLNHRRIGNIAVTLDLMNKIVLHCKENLNVFVKDFLYIMNKVLSNNDVSVVELIELAFS SDLNHRRIGNIAVTLDLMSRIVLHCRENLNVFVKDFLYIMNKVLSNNDVSVVELVELAFG ------------------------------------------------------------ SDLNHRRIGNIAVTLDLMNKIVLHCKENLNVFVKDFLYIMNKVLSNNDVSVVELVELAFS ------------------------------------------------------------ ADLAHRRIGNVMVTLELAEKIVTSCKENLNVFVKEFLDIMIKTLSNLDVCVVEAAEAVFS ADLNHRRIGNVSVTLELMNKIVVHCKENLNVFVKDFLQIMTKILSNNDVTVVEKVEETFG HDVGRNRTGNLQVTLAIIQELIKKCSENLNVFAFQVCYILQSIANTKDLALCKNVVKTFG TDLYHKRIGNIAVTLELMMKIVNHCKENLNVFVKDFLQIMMKMLSNNDVSVVQKAEETFA SDAKHNRAGNLQVTLTIISSLIEECSENLNVFASFVCSILKSVLQSKDLSLCKHAIQTYG HDVGRSRTGNLQVTLAIIQELIKKCSENLNVFAIQVCFILQLIANTKDLALCKNVVKAFG HDAARNRTGNLQVTLAILKELIIKCSENLNVFARQACNILKICLDTRDIAVCKNVVKTYG HDVHRNRTGNLQVTLAIVQELIQKCNDNLNVFALQVCQILQIIINTKELALCKSVVKTFS SDAGRNRSGNLQVTLSIIAALIDKCSNNLNVFASQVCKIMLAILNTQELPLIRLLVQTYG SDVSHNRSGNLQVTLEIISSLIEKCADNLNVFALYVCSILTSILNTKDLSLCKSVVNTYG SDSHHNRTGNVLVSLSIVAALIERCADNLNVFAPYVCSILSSALKIQDIAVAREVVSTYG SDLRNRRVGNISVTLALLDRIVIHCKENLNIFVKDFIFILNRILQNNDVSILELIADVFK KDVSRGRQGNVMVALDIFAKLIEECHEDLNLFAQNVVNTLLDVVNSGDLLLCQHSNKVFA TICRNLDGAYYGGDTEFIKMFKSFVDLLFEVVSKRLNNDDLMLKVCIDISTIIGIASDPQ AICNHLDGSLVSGDSEFLELFKNFVTLYFKVANTKLNDTDLVLKGCLDFSKISNLGSIHQ SICLNLDDVLCNGDMEFIQLYQSFVDLFFKIVTERIHNDDMLLKCCIDISNTNSVSSNPQ SICTNLDGALCSGDMEFIRGYSTFVDSFFKLLTEKLHNDDLLLKCCHDISLTNSLPGNSK SICQNLDDVLCNGDMEFVQLYQNFVDLFFKIVTERIHNDDMLLKCCIDISNTNSVSSNPQ SICLNLDDVLCNGDMEFVQLYQSFIDLFFKIVAERIHNDDMLLKCCIDISNTNSVSSNPQ ------------------------------------------------------------ SICLNLDDVLCNGDMEFVQLYQNFVDLFFKIVTERIHNDDMLLKCCIDISNTNSVSSNPQ ------------------------------------------------------------ SICQHLDGVLCNSDLEFTQMYRSFVDVYCQVVTERLHNDELLMKGCLDISKTANLAGNPG SICHYLDGALCSGDAEFIHLYQVFVNLYFQLVTDRLHNDDLLLKGTIDISQMANLASNPQ VLCENLDGGLFTGDKEFIKIFTEVFQTLVSFGKDRYDWQMISLMAINDISSCLSYNAAVG SICRSIDGAMFNGDAGFIELFKQFVDLYFQVVVDRLHDDNLLLKGCTDISAVANLAATPQ VLCSKLDGGLFSGDKVFVDSFGSLSQNLINIGSENLEWQMISLMTCRYISNCLGYNSKFS VLCENLDGGLFTGDKEFVKIFTEVFQTLVSFGKDRYDWQMISLMAVNDISSCLSYNAAVG VLCEKLDGALFSGDKEFVQDFTDVSLTLISFGKDSLEWQMISLFAIKHISNCLGYTNNSS ILCDNLDGGLFTGDKEFVKIFTDVFSILAGIGKDRYDWQMISLMSINYISKCLSYNQTCG VLCSKLDGGLFSGDKDFVDLFCQLSTGLISQGVSKLEWKRISLATCRHSFKCIGYNTHVS VFCENLDGGLFSGDKAFVDLFTSLSEDLILTGSKNLEWKMIALMAIRHISPCLSHSTKIA TFCTHLDSALFSGDKDFVGKFSDLSQELVNIGENKLEWKLLSLTSCRYVFSCSGYSKLSK SICENIDDSLCSGDTEFVKMFQDFTKLYFNIVKDQLHNDDLLLRGCLNISYTTCLAGNPK LFCQYHDGGLFLGDPEFVRSFKQLLEVYVNMAKVPVQWKIVGLEAAKSIAGSAAIATQTG LNYLVPKCVETAIDQLQARYPQFKENSLLEQPS----LTKRLSKTQTRAQEVLEIPTADN WSATAKNCVSIALTKFQERHPIYSEATIDSSFSEPGALKKKLTRTQTKVMGLD--DVSNT LNHFVSKAVTYTISKFQERNPKFKTLS-LGPVLDGN-LGKRLSRTQTRTVGLD--KTVDG MNHFVARAVKFAIVKFQERNPTFKALS-LTSSTQVPLLAKRLSRTQTRPAGFDLQNTANG LNHFVSKSVAYTISKFQERNPKFKTLS-LEAALESN-LGKRLSRTQTRTIGLD--KAAED LNHFVSKSVAYIISKFQERNPKFKTLS-LEPAVDSN-LGKRLSRTQTRTMGLD--KVADG ------------------------------------------------------------ LHHFVSKSVAYTISKFQERNPKFKTLS-LEAAVESN-LGKRLSRTQTRTIGLD--KAAEG ------------------------------------------------------------ VSSLISRGVELTLAKFQEVQPRFQGES-LQVDLHSS--EKRLSRSQTHLTAAEESRVLGG INHLVSKSVTLALEKFQERHPRYQGQS-LGGDEQP--MSKRLTRTYTRTQGLD--DAHQE -KKFIALSIPVLLQFIIANNPQSSILQRLKSNLHVEDDGKRLSRAHSQKSHSKIAQQIDD GKKLILRAAELSVTKYQERNLQFNVKS-LGASSDQP-IGKRLTRTQTQVLGLD--DLTNS -KKFIEICIPILTETVHANNKQSNLLTILKSNVNIEDENHHRGRIALTKTKQT-SRKAQQ -KKFIALSIPILLQFIIANNPQSSILQRLKSNLHVEDDGKRLSRVHLQKSHSKIAQQIDD -KKFIALSIPYLIQVIMQHNNISSLMQRLRTNMNVEDGTKRLSRVQSHKSQNLINKQIDE -KKFIALSIPTLIQTIATNNSQTVLEKKIRSNLHEEDNGKRLSRVQSQKSQRVIAQQIDD -KSLLSLCVPLLTEQVHSSSSHDDLLKRLHANLNVEDADRRLSKSVTGRSMSKMYR-VKS -TKFINISIPFLLKTIHSTNSQSNLLSRVRSNINVEGDDRRLQRVLLSKVPQNIHKQIQE --KFIRSCMPILVDFVREHVTEEELKSRVSSQIKVE-NDAHVSRVISNRL-----STYKN LCDLITKSVHYTLLIFQEKYPNFKTTS-LHSAASLP-LTKKLSRTHTRTGISLTDGSLAS -STSISPIVHLLLSSLQESQSDLEQLD--------HDLGGGLPDNIGGSKRNSMHQDAID ---DLCVATLHNYFNTTETDKLNLSIRSLIKKLQSTPNKELLEFISNDIPVQLRYIVVLL G--DYSILALNTFFNTTETDKLTIGLHALIEHLLETPNKELLQFICNGIPVQLRYIVILL NN-DISIRALQSYFNTTETDKLNLSIRTLLGCLQNTPNKELLEFICNGIPVQLRYIVILL DEPDISLRVIRAFFGTTETDKLRLSINALLDLLQLTPNKELLEFICNGIPVQLRYIVIIL NH-DLSVKALQSYFNTTETDKLNLSIRTLLRCLQSTPNKELLEFVCNGIPVQLRYIVILL ND-DLSVRALQSYFNTTETDKLNLSIRTLLRCLQNTPNKELLEFICNGIPVQLRYIVILL ------------------------------------------------------------ NH-DLSVRALQSYFNTTETDKLNLSIRTLLHCLQNTPNKELLEFICNGIPVQLRYIVILL ------------------------------------------------------------ YPE----QALQSYFSTTETDKLSIAIRALIKRLLEVPNKELLQYIANTIPVQLRYILVLV G--DFSIAALQSYFNTTETDKLTLSIHCLLTRLLETPNKELLQFICNGIPVQLRYIVILI DFTEKAFSSMKSFFNTNAASQISEVTRAVVQHNIGTDLESFLELCITWIPVQLRFVSLST D--DCAVEALRSFFNTSETDKLTLSIDALLKVLLKTPNTGLLQFICNGIPVHLRYIVIII DLDEEALRGKKALFSTSLTSQTSEATRAIVKNKHIDPMGTFLEMCTTWIPVQLRFITLST DFTEKAFASMKSFFNTNAAGQISEVTRAVVQHNIGTDLESFLELCITWIPVQLRFVSLST DFDEEAMNALKEFFNNNTTAQISEITRAVVQHVYNINLDVLLELCVTWIPIQLRFVSSST NFLEEAFSSLKSFFNTNTASQISEVTRAVVQHNMGTDLELLLELCITWIPVQLRFVSLST NADVEALSALRTLFNTTLSSQISDATKEVVENNLSYPNETFLEMCASWIPVQLRFITLST DFDEEALRSLKALFNTTLTSQISLATRAVVKYNYKTDLKTFLEMCTTWIPVQLRFVSLST GSEEEAFSALRTLFNTSSSSQIVEATFELVKHCYRAPNSSFLALCTTWIPVQLRFTALS- ---DASITVLKSYFNTTETDKLTLALRAVLAQLQVTPNKELLELICEGIPVQLRYIVIIL NFIYLSFHALRTFFDTTSVVQIQSATRAIVTYIINVPEHSLVVIVAKWAPVQYRFVILVS LTRQVSNYERNPDGALNSLKLISCLLVSKISIVGLSVLDIMRKVLAVQLKSKESMPLVHQ FVRPLGTS--SEKNMLLILKLISSLLTSAVSIIGLSVIDILRRLITVQLAKSDSTTVVKQ LVRQLNDKD-KNVDAVVSLKLMSSLLVSDVSIVGLSVLDIMRKLLNFQLKNVANKEVVEQ LVQQLSDISIKKADPLVILKLTSALLISDISIVGLSVLDIMRRLLKFQLDNYKNSEVVSQ LVRQLSDKD-KNVNPIVSLKLMSSLLVSDVSIVGLSVLDIMRKLLNFQLKNATNKEVVAQ LVRQLNDKD-KKVDPIVSLKLMSSLLVSDVSIVGLSVLDVMRKLLNFQLKNATDKEVVEQ ------------------------------------------------------------ LVRQLSDKD-KNVNPIVSLKLMSSLLVSDVSIVGLSVLDIMRKLLNFQLKNTSDKEVVAQ ------------------------------------------------------------ FTHALNQ---EDEHAVVLLKLMTTLLVSDVSIIGLSVLDLLRKIINFQLASATSPQVTEA LIRGLNE---NNDHALVTLKLVSSLLVSEVSIVGLSVLDIMRKLLNIQLSNNTSTSLAKQ LLATLGRININYNMQFQYARYLLGLLSSRVNMIGLSVSDIIQQLLSLQADKSEISILTDI FIRQLHK---DNEQSVVVLQLISSLLVSEVSIVGLSILDVMRKLLNTQITEGVTQELRDR VLSSLTSLSNNYPIQLLYANYCLGLVSSDVNMIGLSISDVIQQILFLQAQEEDVKKLSMI LLATLGRININYNMEFQYARYLLGLLSSRVNMIGLSVSDIIQQLLSLQADKSDISILTDI LLATLNRMNVNYQVQLQYARYLLGLLSSGISMIGLSISDIIQQLLNLQTSNSEIDGLTNI LLATLGRININYNSQFQYARYLLGLLSSKVNMIGLSVSDIIQQLLTLQTDKSDISILTDI LLKSITTSEKHFARMVHFAKNISGLVSSDFNMIGLSITDVTQRLLSLQTPADKVAYLSSI LMARLTTISSSFGLQTQYASHILALVSSDVNMIGLSVSDIIQQILSLQSKPEQVKRLSSI LLQKLDSSDLDFELQKHYASYVLALVSSDVNMIGLSISDIMQQLLTLQSESDEVRQLSSL LVRQLSEKSTNYDTTL---KLISSLLVSNVSIIGLSVLDIMRKLLAFQLENAENDNIVHE LVEMLVAMSPNVKSELVVAALIHALLSSTVNMVGLSVMDILGSLLNKQAASGAFEELIDK CRVTIKDLNNKIYYSEQTSDMLYDLVVKI-----KNVQNEVEKRILVDDMKYIVDDISQ- IAVTIKDLNRKTYYKQQSSDMFAELSFKF-----IESGKPHHLELFQLDLDSLISV---T SCITMTDLNHKIYYTEQTSDMLYELLLKL-----KSDTTNDEKNAVVEDVDFLVEH---I CALTIKDLNSKTYYKEQTSDMLYELVIRLKSTADISAKEKKRTDILTNNVSQLVKY---T SCITMTDLNHKTYYAEQTSDMLYELLLKL-----KSDTVKDEKNAVVEDIDFLVEH---I SCITMTDLNHKTYYAEQTSDMLYELLLKL-----KSDTINEENNAVVEDVDFLVER---I ------------------------------------------------------------ ACITMTDLNHKTYYAEQTSDMLYELLLKL-----KSDTIKNEKNAVVEDIDFLVEH---I ------------------------------------------------------------ CTNTISALNRKTYYKDQPIDMISELLLKL-----KEHPGQREKDILISDLQAVLQT---V CSATITDLNQKIYYKDQTYDMFSEILLRL-----KDENDEKHKAVLVGDLHSLILS---T YSDCICSLTTHIYYFDQVPDSIQEILIKISSFVETGEQIQDLIIQLLDNISKIFLILKNI CAKTIGDLNRKTYYKDQTSDMFSEILLRL-----KDERNIKYGSIFRRDLQELTLS---T YSNCICNLSTHIYYFDQVPDSIREILIKVNSVISNSSGVYRFIITLLEDISIIFDLLQTI YSDCICSLTTHIYYYDQVPDSIQEILIKVSSFVDTGEQIQDLIIQLLDNISKIFLILKNI YSDCICNVATHIYYYDQVPDSIQEILIKVGSFVDSGEKVHNLIVQFLDNISKIFLILKNI YSDCICSLTTHIYYYDQVPDSIQEILLKMSSFVDTGEQIHDVIIQLLDNISKIFLILKNI YSECICNLSSHIYYFDQVSDSIEAILVHMSTTADNVEQVYGLVLHLLDDVSTVLNLLSAI YSGCICNLASHIYYYDQVPDAIQEILVKIFSFVDNANNIHNLVMTLLGDVSVIFSTLTKI YSQCICNLSTHIYYFDQVPDSVQEILFKITVFLSQSKQVYDLVMTLLGDIANILTTLRKI CYTTISDLNEKIYYHEQTSDMLYELLTRL-----RIDTSQINKSILVNDVINIIRN---T LSACMISLGTHIYYADQISDMVGEVLWRCATGGTSHDNSPDVLIRRLAIVEGFFRLQNET --PVINVDLLTELVPFMKGS----VIQLLNITEEHISGGSTLSRLFQMVRDIEDRNLQSK SDQCLDLDLFGEFLPYVTD-----KTQLSKLLYPEAPHQVIF---IRFFKVSTLSKDTEI TQPSISLELFIDLAHYMKNH----IISLFAIVETEVPTGFVFSKLYSLLRELDSHGVQKE AQQCISLELFMELIPFTKH----MVISLFNIVENELPSTLTFNKLLEGLFELPEEETQKI TQPSISLELFIDLAHYMKNH----IICLFNIVETEVPSSILFSKLYSLLRELDSHGVQKE SQPSISLELFIDLAHYMKNH----IICLFTIVQTEIPTGFVFSKLYSLLRELDSHGVQKE ------------------------------------------------------------ TQPSISLELFIDLAHYMKNH----IICLFTIVETEVPSNIVFSKLYSLLRELDSHGVQKG ------------------------------------------------------------ GQPFMTLELFLELAPYVPD-----RLELFSLVTDKLPGGFVMNKFFLFLVALESPGEQEK YGPSINLDLFLELAPYMDEYD-----SLFEIVDDSISGSFMA-KLFKFIGTLSTEEEQVL NRNHVNLEHWDISLGLLAPQGDHIQAKYLKVFDEFLNNELAVSRLVEGVNKSDDSDNGKD YSPSLSLELFLELTPFVDDP-----YKLFHVVGESVSGSFALSKLFHLIDSFKNEDQQSA SRNHVSLEDWDLSLILLSSEIGLIQFKYLRVFGYFLNNELVTENMETGANSIESFNVGGD NRNHVNLEHWDISLGLLAPQGEYIQAKYLKVFDEFLNNELAVSRLVEGLNKSDDLDNGKD SRNHVNLEHWDISLGLLAPESEFIQAKYLQVFDEFLNSELVISKLASSELSADESGAGKT NRNHVNLEHWDISLGLLAPESESIQAKYLKVFDEFLANELVVPRLNDILHDKDSQEKGHD IRNRATLENWSVSLQLLSFSLSYIQAKYLAVFNLFLEKELVK---SDSPQSDSKIGERDD ARNHVNLEHWEISLPLLSPESLYIQIKYLKVLHDFLTNELSAGNTFESVNSENLNGTVKD TRNQVTLEHWEISLPLLAPPSEDIQIRYLEVFQDFLKHELVSDKKTQVSLSSESIQDINE SNPCIGLDLFLELVPFINDDINN-VLSLFDIVDDQIATGFLFSTLFKIIVDMSRNEEQGI AHNSVPLSAWDGTQYLLNHDSAIVKEAYVFCFVAFLEYEF---------GNPDRFQ--IG AMSIIFDKYKKIILLPGLNYFQMNIKEPEYTYYLYHFNAAKTLGVTSYYSETQQKLDNGE AISTSFAYYKAASLLSGLAYYVNNN-RPSDGYYAYHHHASKFLGLADYQTQVEFKRKDND MMEEIFDKYGKVALLSGLHYFLENVFEPEYTYYLYHLQAADFLKLNDYKSQTEYKMETKT LMEKIFEKYGKFALLSGLTFFLKNGKEPNSVYYFYHMEAAKFLQLDDYTNQVQYKRDTHS MMEEIFDKYGKMALLSGLNYFLENVSEPEYTYYSYHLQAANFLKLNDYKSQTEYKMQTRT MMKEIFDKYGKMALLSGLHYFLENFSEPEYTYYLYHLQAANFLKLNDYKSQTEYKMQTKM ------------------------------------------------------------ MMEGIFDKYGKMALLSGLHYFLENVSEPEYAYYLYHLQAANFLKLNDYNSQTEYKMQTKT ------------------------------------------------------------ LLDDAFAKSKNFTLLSGLIYFLEKGNTPSNLYYCYHTKAARFLEFDDYHSQAQYKRQERE LMSKTFSKFKGFALLSGLNYYQEIVNGPLPGYYIYHTEAAKFLDLEDYKSQTQFKKENKL FKKPDANQYNQQNFISHFLMYIDKFFENYDSPMMNILGLNFLSNFIPFFHHWVMKVNRAS FISAAFQKFRGIALLAGLKHYLDIAGEPKACYYMYHREAASFLSISDYRSQTDFKKKTGD HLQPDYNNYDPGNFIAHFLGYVDKFFSGQSLIMILILGINFINNFVPFFFYWQLPLNP-N FKKPDANQYNQQNFISHFLMYIDKFFENYDSPMMNILGLNFLSNFIPFFHHWVMKVNRTS FTEPDINQYHQQNFISHLLMYTDKFFDTYDSPMVSILGLNFVSNFIPFFHHWVLKLNRTN YRQPDANQYQQQNFISHFLMYIDKFFESYDSPMISILGLNFVSNFIPFFHHWVMKVNKST MLVPNFNDYNSQNILAHLLVHCNDFFEDSILNILHATGANFIHNFLPFFQHWQQSTYSSS LLKPNINQYNPNNVISHFLLYVHKFFNFHESPMLNILGVNFVTNFLPFLYNWLIPLNDIS FTKPDFNDYESENFICQFFIYLDRYLSREVDALLSTLGINFVANFVPYYFHWQLALNQSS MMRKVFNKFSNIALLSGLNYFLEIYNEPEPAYYYYHEEAATFLNLDDYKVQTKYKMENGL FGRRGYNQNVAYGFVSHLSMQLNKLITNTRATIVIRLQQDGVVATFPHMLKAHELGRA-- LFTKEELMKYYKNANNTQFGEKGMQILMSY--DNQISNSDLLNDRPLSPVFSSKPLSSPM IFTKEDLLNYYSDAGSNIYSEKGRDILLVDHSDQNGTDID-----QDTVRYST--PIPLP LFTKEDLLSYYSDMGSNKYTNRGAQILMSR--DNQISTSDLLSDLQGRTDYKAVPVFPNG MFTKDDLLNYYSDPGSNKYSKIGSQLLLTK--PTHVSTSDLISDTQGRTITPDVYKSISN LFTKEDLLSYYSDTGSNKYSKKGAQILLSR--DNQISTSDLLSDSQVRTEYKNVPIFSNG LFTREDLLSYYSDTGSNKYSKRGAQILMSR--DSQISTSDLLSDPQVRTDYRTAPILSNN ------------------------------------------------------------ LFTKED------------------------------------------------------ ------------------------------------------------------------ IFTRNDLVNYYSDPGCNRYAEKGLRILISQ--NTRVSTTDLTETPPE------------G LFSREDLINYYSDSGSNKYSEKGAKILMSH--VNHLSTTDLVSDTPEHL------TSELP NFTQRQKFKDTFAHIILYYMLKDLDEQYSHDLQNYCKSSKLFKQILDAVEYRKMQKFWVH VFSRDDLLNYYSDTESNKYSEKGRKIIASK--GTNISATDLLSQYNGN-----------E LVDDNTRIKDTLGYTLIYHSLIKMDKIYEL---NYVRESEFFNSLLGDINYRKLNKLWVN TFTQRQKFKDTFAHIILYYMLKDLDEQYSHDLQNYCKNSKLFKQILDAVEYRKIQKFWVH EFTQSQLYKDTIAHILMYHILKTLDKQYEDDLAGYCKASKLFKHTLDAIEYRKLNKLWIF TFTQRQKFKDTIAHIILYYILKGLDEQYSHDLQNYCKNSKLFKQILDAVEYRKLHKYWVH ---LSRRVKDTSAYILLQDSVEVLESKYNDCFKSDVHSLPLAAFISEDIISRRERGQWVC DVPSNAKFRDSIAHIVTYYCLKTLDDKYPDDLEGYACGSKFFSKLLRAVEYRKVNKLWIQ -IEHQDKVKDTVAHIVMYYSLRSLDAMYPTELQGYVSKSSFYANFLVDIEYRKLNGLWVE LFSSDDLMNFYSDAGTNKYSKRGIQIILSQ-GPSHLSSFDTTDSNMTRSLSESVQRSFSG LVTGQSSESNTLAQGI---IIEDIFTLYLKQVGDVSDAADLTVQAGDEVALRKKLGLWPN GLISPQA--------------------QTNTQLNQPMRFVSDDVHSWKVSRPSIPKVSDL QISIPPTTTNGI---------------GIKKSSPANDTY-----VTRSLKHNPVPNVKDL NAMPHNKDVAIKQNRFDKSIDDNVDEGSDANAKGSIYRFVAEDARSWKTMRATAPKISDL GFLSEAMVKTRNKANNNITDDDQT---PALATKTSIYRMVSDDIKSWRSMKSRTPKISDL KAVYDNNDFAAKQNKFDNSIDDNIEEASDANAKGSIYRFVAEDARSWKTMRATAPKVSDL NAISSNKDFAIKQSRFDNSIDDNIDEGSDANVKGSIYRFVADDARSWKTMRATAPKVSDL ------------------------------------------------------------ ------------------------------------------------WLS--------- ------------------------------------------------------------ ELQIPDIPL------------------PPTPPTPQQHRMLNSDASVKSLDKMKSPKVSDL TIIAPP---------------------VPNSPRKNFSQM-LNETHSLRSMRYTSPKVKDL GIDPSPSDLENTKGDRTIPTDANGNYIAIRIKPENIEEFACGNNFLIVWLHPQKQLLTEI GLQSSSHLLTPP---------------PPSTNYNHMPKFLSGDARSLKTLRYSSPKVKDL GLQSKEEDAVLD-NHHALGHRDENGTLRFNPTKKNLEDFVIGNAFTLSWINPHRPLILDI GIDSSPSDLETVKSNRMIPTDSNGNYIPIRIKPENIEEFACGNNFLIVWLHPQKQLLTEI GLDAGSFELDSNKTNRVLPKDANGVDIKLRIKSENVEEFACGNNFLIVWLHPQKPLLTEI GIDSSPSDLESTKSNRVLPTDVNGNQIPIRIRPENIEEFACGNNFLIVWLHPQKPLLTEI ELDGTSSTPKII-----------PGELSMKVNKKSIFDFFSHISLH-GWTPSQGPFREA- GLDSSPTDLEIIKNTASINANDTNS--KFSFTRKDYDDFVCGNNFTIVHINPAKSLDLNG QLSAHPTNFEVMKNSNPKSHQDRNGVLRFNTSRKAIQDFVNGNGFTATWINVNRLLRLEI GVIGQPSTAP-----------------TPTTSSAMLGMMLSSDSKSLNNFKGKSPKIKDL YLDWPVSSSS-----------------RIQDADAQIDTSMVAKMKTLSRSEVEGLFAEYV KK-AMKNGSSTKNKPLR-----GSQSVKSRVTNITFLLSELRSTTAGDDSHI-PDEEEVV KNL-----VSSKKDKSNTKTLRGSQSVKSKVTNITFLLDELKNDGDEIKIAD-PDEEDII K--KAINERKTPNDMKRDGSLRCSQSVKSRVTNITFLLSELKTFSEDANKIEDPDEENIV KK-AASRKKHSKEHTDKDTSHLGSQSVKSRVTNITFLLHELKTNNDGENDKVDPDDDYVI K--KTMNEKNIPNNMKRDGSFRGSQSVKSRVTNITFLLNELKTFSDDANKIKDPDEENIV K--KTMNERNTLNSVNRDGSVRGSQSVKSRVTNITFLLSELKTFSEDANKIKDPDEENIV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ KRA-----ARGIRVAPSHSSLRASQSVKSRVTNITFLLNELNNESQETGIYD-PEEEEVV K--NVID-RKSSTIPKRNNTLRGSQSVKSKITNITFLLSELSHGSEEGKVRD-PDEEEIV EKSDSRNTNMTVIMDQGSSALSSASSNSEKGLYTGLGLGTAGDITMIHSEILILRTVDSV KVA-----GTTSSQNKRNGLSRGSQSVKSHITNITFLLSELDDDSREVKIRD-PDEEEVV VNNKKENNQNVLSDMSDESSIILSYHTSARQNGFGLGLGNANDISSIHSGLLHQSQNVNM EKSDSRNTNMTVIMDQGSLAVSSASSNSEKGLYTGLGLGTAGDITMIHSEILILRTVDSV EKSDSKNTNHTFLDPLSNGNMNAASSNSERGLYTGLGLGTASDIQTIHSEILSINETSFF EKS-----ISTHMSTFNNDS---------RNTNNTFMVDQGSSFGSGPG----------- ---DVLLENGNGYSEHSMNGQLDFRPVNTKPVGAGLGLGTVSDISSIHSGLASSRANVGS ISTSGILGPESEVHSLIELLRH---------SGLGYGLGTVGDISSIHSEILTANGTFNS QK-HSHNESPSNIPVFSEASSFSESGSSSSYRRAGLGLGNANDITSIHSELVQNNGRNHY RIA-----KKNPSGQDKENTILGTESLKSRVTNITFLLSELKSISTEVNKIQDPDEDEIV T--SMPQETRAELFSDYDDVMT--IHSRQQVPDENLIVGKARSLKQLNAGSIQTMRDGWL GIDKMEIARSLSGRGRNSVVVED-VSTNRASFVPATV----NEDDEFRDAVEDVEASTSR GMEKQDLARSYSLRMNTI-------SSTNSRTLIPSVENAEEHGDDFRDAHEDIEVSSTR GLDKIDVARSNSLRLAPISSISDRSSIGNRRSLIQKTPVAEDQDDDFKDANEDLHSLSSR GLDKAGMIRSQTAKLNSGNTISVRSARNSVLINSPSDRILGDIDDAFEDAPEDIAISTSR GLDKIDVARSNSLRLAPISSLSDRSSIGNRKSFLQKTATGENQNDDFKDANEDLHSLSSR GLDKIDVARSNSLRLAPISSLSDRSSIGNRRSLLQKTPVNEDQFDDFKDANEDLHSLSSR ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GLEKTDLARSISAKVSPA-----IAYSSKRFGNLTSSLDLELQEDAFQDASGEIEASAFR GMEKFDLARSHSTKLNSM------NNSNSKRLSIPLV---VRDEEDFKDASEDVEVPSTR NSTNDGLIYTYDSKYLQSPRVSDANMTDSASTSNGSVLNKNMQTTDVDSILSGLE-SEDE GLGKSALARLESLKLLNI------TPKGAKRLSIP--IRLQENDDDFKDANEDIQVTSTR KNETSNGSIYTSDRQYNTPRVSDFNEHYNSDTTPGSILSKQMVTSDIDSILEGLD-IDDD NSTNEGSIYTYDSKYLQSPRVSDANITDSASTTNGSVLNKNMQTTDVDSILSGLE-SEDE D-DCNGSIYTFGSRQVNSPRVADSSRAMENTVSNDSVLGKNLLSHDVDSILAGLE-SDDE -MTANTTASAAAAALAHSSSIAE--EAGGHFIPPADFVQRSGLSSDAAS-------SNSE AIETRSMISLMAREEHRVPRVAPLNGLSISGASSPSVLEKQIHTTDVRSILDGLD-SDDD DITSSSILTSDG-RYVNSPRVADYRKTSHIGQTPGSVLGKQMVSTDLESILTSLN-TEDD DYSNGSVLTSEQPRFFNSPRVADSIASAKIKPNAGSILSKSMMTANVNDIVKDFD-SDDE GLDKIDLARSNSLKLTPATSIAS----NKNRLQ----TDKENEEDNFKDATEDFELPGSR G-DDVKNNKFAEERKGFTPTVSD--LKGAMGGNAYVSKEPIAQKFDPQTFLNTWTVTDNL GKIFANWPVCLSYFDPFDVFGAVQSEFSSIFPLDVVRWKTNDGSVRTIENLPVKLTVEDD GRLFMVPRVQVSYFDPFHVFDGLRNEIEQRLPLTNLHWKSKGGALKTISSLNVKFISSTG GKIFSSGSVPISYFDPFDLFESLKPEFQQILPLDNVHWKAPNGTVRTVNKLPIELIPEDR GKLFS-GNVSISYFDPFDVFASVKKEFIKILSFENVHWKSPNGTVKTVNRLSVDLFPEND GKIFSSGSVPVSYFDPFDLFESLRPEFQQILPLDNIHWKAFDGTVRTVNRLPIELIPEGR GKIFSSGSVPVSYFDPFDLFESLKPEFQHILPLDNIHWKAFDGTVRTVNKLPIELIPEDR ------------------------------------------------------------ ------GSVPVSYFDPFDLFESLRSEFQQILPLDNIHWKAFDGTVRTVNKLPIELIPEDR ------------------------------------------------------------ GKLFSSYTVKVSYFDPLAVFDTVRPEFDARLPLGTLHWKRPNGTLKTITQLPVEFEPSLE GKLFSTHRVHVCYFDPFEVFPSIQLELEHRLPLQNLHWRSPKGPTRTIGSLLVNLVAETE AAFVV-NPVKIGYYDPFGIYPLIKDELNKISPISSLHIRHPSQPLKTIHDLSLEFTEEIP GKLFTANIVSFSYFDPFNAFESVRPELESRLPFKNLHWKPANQSLRTISSLPVKVIPETD SEIIV-NPVQVGYYDPFNVYPLIKDELQSKLPLTNLHWKNISKPLKSIPLLPVTFVEEVP AAFVV-NPVKIGYYDPFGIYPLIKDELKKISPILSLHIRHPSQPLKTTHDLPIGFTEEIP AAFVV-MGAKVGYYDPFGVWPEVQQHIHHQLPFKNTHVQDVTQTYKTISQLPVHFVEEVP AGFIHWNTIGIGYYDPFAVYPLIKDEIDKLFPIQNLHVRHPSQPLKTINNLPIKMIEEIP REIIV------------------------------------------------------- SRIIV------------------------------------------------------- IVV---HPVRIGYYDPFNTYQAVQNELQHKFPLTNLHWKNSLKPVKSIPVLPVELVEEIP GKLFASSGVVFSYFDPFAVFDSVKNEFLQVFPFKNIHWKTSSGLVRTIENLQVRLASEDG GGLTV-KKTRITYFDPFGVFGNLEEGLRKRLPLQNLHWSSGDKPLRSIPRLDVELVEDVA QQQSNEPYIRLIVVTCISVDEYRTKVRPLLHQWLPTGPFTMPLILLYANSEVTDTSIFKM EENSDKPFINCVVISCESVEEYRSKIRPLIKNWLPS-LYCANIVVLHSNKEVLDSNIFKV GDGDKQPFLRFLIVNCISIDQYRAKVRPLVRQWLPSSMIYKPIILLYANSEVVDSNLFKV NNKNKTPYIKFIVINCISVDEYRAKVRPLLREWLPSKMESKPIILLYANSEVIDSTLFKV GEADKQPFIRFLIVNCISIDQYRAKVRPLVRQWLPNSMIYKPIILLYANSEVVDSNLFKV GDGDKQPFIRFLIVNCISIDQYRAKVRPLVRQWLPNPPIYKPIILLYANSEVVDSNLFKV ------------------------------------------------------------ GEGDKQPFIRFLIVNCISIDQYRAKVRPLVRQWLPSSMIYKPIILLYANSEVVDSNLFKV ------------------------------------------------------------ AGSDDKPFIFMIFVSCASMREYRNKVRPLIRQWLPAELPSEYMIMLHSNTEIVDSNLFKV DVKDDKPFIEFIVVSCTSIDEYRAKVRPLIRKRLPVSLPMKSIILLHSNAEILDSNLFKI KKSESNVYTRLMLIKIESLDKYRSQVRPLIKEWLKNKPSWMILLYVPSDAKDKQSTIIKM GDVDPAPIIKFLVINCSSIDEYRAKVRPLVRQWLPSSVPAKRIVLLHSNSSISESNLFKV KHTLVKMYSRIMFIKYENLDTYRAQVRPLIKEWLKQEVEWAIILLMGSSLKDKLSTIIKT KKSDSNVYARLMLIKIESLDKYRTQVRPLIKEWLKTKPSWMILLYVPSDAKDKLSTIIKM KTSDYSIYTRLMFVKFNDIDTYRGQVRPLIREWLKHRCTWMIIFYIPPEGKDRHSNLIKT NKKSDGIYSRVMFIKVESLDKYRSQVRPLIREWLKNKNSWMIILIIPSDAKDKQSTIIKM ------------------------------------------------------------ -----------MFVKIDNVDVYRSQVRPLIREWLKNHVEWMVVLYIPPTSKDKNLTIIKT KSSATSVYLRLMFVTYDSLELYRSQVRPLIKEWLKKSVEWMILFVMPSGSKDKSSTIIKT ESNGEDPFIKFLVVTCKSVDDYRSRVRPLIRQWLPTASMSMPVLLLYANSEVVDSNLFKI QHGEAEPYFAIMFVRCDDTETYKSSVRKVIRDWFNRSIEWMIVNWKSNKSRPK------S SVMDKLNKDFPDVQALELKSVPAEKTEFWLKLSNKLKAFLIEVFQHRIRILESKLTRQFT SLIEKFNKDFPSLKTLETKTVNDERETFWNGLINKLKHYLLEVFENRIESYSSALQREIS SLMEKFGKDFPHIQTLEVRSVPKDRQEFWNQFSQQIKASVLVIFQQRLTHLQHSLATLQK SLLDKFAKDFPDVQTLELRSVPKERDEFWSQLSHHLKNQLINTFQRRLDYLKNLLKNSNT SLMEKFGKDFPHVQTLEVRSVPKERQEFWNQFSQKIKASVLSIFQKRLTHLQHSLANLQK SLMEKFGKDFPHIQTLEVRSVPKDRQDFWNQFSQQIKASVLGIFQQRLTHLQLLLTNLRK ------------------------------------------------------------ SLMEKFGKDFPHVQTLEVRSVPKDRQEFWNQFSQQIKASVLSIFQKRLTHLQHSLANLQK ------------------------------------------------------------ SVMEKLNKDFPSVRVTELRSVSQEKQDFWAGAVASLKNTLLEIFQRRLEIFQQALGEEDL SLVEKFTKDFPDVKTLEVKSVETEKNYFWTNFMNRLKQDLLDVFQQRLDTLAARIDQINH SHYDKLLKDFSNEGAQNSKSTKFKQHEFLNEFLVQIKNLLGFTFNQKYHLNSDLITTSGD SFSDKFYKDFPFLQVVEVKSIEKDKGDFWNNTVYQLRKYTMEVFQQRLGYLESELRSVTE SIFDKLKIDFGIDRCFKLREVDMTKLESYNELINHMKDFLVSSFNNKYVSFNQMIYNHQA SHYDKLLKDFSNEGVQSNESMKLKQNEFLNEFLVQIKNLLGFTFNQKYHLNLDLITTSGD SHFDKLKLDFGALRCFKLKVG--HDADIWNEFAAQLKSQLVSAFCERYSKYKTAVHEGK- SHFDKLLKDFGQDSNITPNDFKLKQNELSSEIQANIKSLLSCSFNQRYHLFVDLIKQHKE ------------------------------------------------------------ SSFDKLKIDFGDERCFKLKPEDSSKQNPFVEFAVVLKDHMVASFDESYHRFSDSLAGYKD SLFDKLKIDFDTSRCIKLRQKDFAKTESYTELISQIKSMLLNTFDSKHQQYNDMLSTYNQ SLMDKFSKDFPDVKTMEIRSVPQEKNEFWSQLSNQLKSSILAIFQKRLEKYLHQMDVITA SVFDKIKSDFNTDRCIQVREDAEDLIDFWGDLISRLKEGVLDTFSMRVDSYEKEIAKLEA ELEIREQLFKIYAEFRRTEDAKGQLSMIKNLMDKRKNVETGKLEVPFEMSGKESTKQLLS AVVLHENSLKMYLSFQLIEEASTEISRLDELLNNEFLLIAGDLRTPLFNQFAISISTLIS QLLTREKLYELYVAFNILEDANLELQKIKREILHRMNMPDGQLQIPFESSKSDSLSSIII ELLIRENLFELISSFELYDEGIEQLNIIKDRFIKELELPKGNLEVPFELVVNRSISSMLS QLLTREKLYELYVVFNILEDASLELQKIKKEILRRMNMPDGKLQVPFESSKSDSLGSIII QLLTREKLYELYVAFNILEDANLELQKIKNQILHRMNMPDGKLQVPFDSSESDSLGSILI ------------------------------------------------------------ QLLTREKLYELYVVFNILEDASLELQKIKKEILHRMNMPDGKLQVPFESSKSDSLGSIII ------------------------------------------------------------ ELVLQENLLKLYLSFNVYEEAAAQLDVIKDNLMADQNLPAGELEVPFMLPSSCTLSRLTA VLVLHENMLKLYLSFNIFEEASTQLSDIKEKFLSCVELPSGELEIPFLFTNDERVDKLVK KYVATYNLAELFYDMKLFNDCINFFNRLSEQLNTKVDLPAKVFSNKFDFKNKCHMHDVNS VAALQENILNLFLTFHLNDEASKELDALRDTLFARVNLPQGDLKVPFYTSAHQPITHKLE AFILKLKLADLLNDMRLLNDSLSIYNELSNDLNKETHIPSDLNGYQFEQSFSSSIKNSLN KYVATYNLAELFYDMKLFNDCINFFNRLSEQLNNKVDLPAEVFSNDFDFNRKCHIHDANS QILAKLKMYYLFCDMCLLQEARLWNTKLIDDLRRKKNIPQSLDDFKLQTMSNESLKEQLL RFVAYYSLTNLFDDMRLFHDTLSQFEISNQELNHTVTLPESFDGFNFEKFIDEKIKSNLY ------------------------------------------------------------ KFRTRLALADLLYDMRLFQDSLDVYKELDDDLNAHRKLPKSLDKFKFDDWVDELQLSFHS SLLAKVQLARLFYHMRLLEDSLAIYDDLYSAINISFDISVDSNNFNIDTLSSFDPDKLLQ QLLMREKILNLYLDFKIDEEATSSLDKLKLDVQSKIEIPIGSLEVPFKYSVHDSVAQMFR FFVAKEGLGVSFENVALYDDALQVYDELEASYQE--KIGFEKVDVGILEPQHEDIKLEIL AKNLTKFTLYRSNFLRELMLLQLYDDDISKYTQIYELTKDFIRKIEKEFAADLLEFKFDF KDKITYFGVQKCILQAELELYMVSSNANNSERKLNAAFHKFLSRLHVSFHSDWLQFKYSA EGTLDKFQLHRYFFIRRLRLLKLEDQTLAAFVGAYQLIKNFIESVSIEYKKSLLEFKHSF DKQLSKFEYYRYFFLREFNLLKLDNNLPTDLLTAYQLIQSFIVSIEINFSQSLLEFKFFF EGTLDKFQLHKYFFIRRLRLLKLEDQTLTAFVGAFQLIKNFIESISIEYRKSLLEFKHYF EGTLDKFQLHKYFFIRRLRLLRLEERTLTAFVGAYHLIKNFVESISIEYKKSLLEFKHYF ------------------------------------------------------------ EGTLDKFQLHRYFFIRRLRLLRLDDQTLTAFVGAFQLIKNFIESISIGYRKSLLEFKHYF ------------------------------------------------------------ ENALTKYKLYKYIFKQQRELLLHTSLLTLAYHMYLSIVRDFYSQIKLAFHQSLLQFEYYF NQKLNSFKLHKYFFVKQFELLQISDFSAKKYSQLYRLIRQFFSSIEQAFHESLLQFKYFL FTNVNLFELKCFIFFRQASTLEMISLAELQISKLLRNLVLFLNDLLQVFQNELIEFEYSI EQRLTTYELKKFFFIKQCELIQNSYTQAAGCLRFYQVVKEFLRTVEQDFVGSLAQFKYSF KEKINLFELKSLIFVNQSSLLQLISLSSISISSIYQKLLYFLNDLSNIFGDKLNEWIFVV FANVNLFELKCFIFFRQASTLEMISLAELQISKLFRNLVLFLNDLLQIFHNELIEFEYSI QGNIDLFGLRCLLFTNEGSISKLLPTASKEIAHLFQILIVFLRDLEVDFSRH---LEYVI SGNVNLFELRCFLFFRQSYTFKLISIGALQISKLYRNLALFLNDISKKNSTDLKEFEFSV ----------------------------------------------------MNEWFCAL NTKINLFGAKCLLFKNQSVLFQSVSISAIYISNLYQKLNYFLNDLCNTFEGSLDEFAYCI SPPVNVFCLKSSVFSAQTQILRAPSSSIAHVGVMLKRLSRFLNDVSSDASCDVNEWMFAV DNTTSTFLLYKYFFYRKFELIKLKSTKNQQCIRMFSLARLFLKTINKLFKDSLLEFQYSF ANEVSLFDFRCYLFGRQVTQLLLPSISALFMSQVLSRVLSFQREIRTLLYSNLMVWAYHV CKKMLDTIPSTSRSEPTINEIKADIYLIKRDAWIHLMINHGYQLLQKNYSNKTL-YSFGL YDEFINLTTFDDIKSDTWKLVLCDMKNEQRECWIQACSRMGYKIPLKDFRKEVTPEVNPS LNSMLSYFPRENIGNAILCEIKAELLMLKRDNWIQVLIASDFKLMDKSYTNTDVPYTFDL FEAILKRLMSDNLIDPLVHEIKGELLMKKRDCWLNVLTNTDFALMDKSFINNPVPYTFEK ITSMLSYFEFENVSNPLLCEIKAELLMLKRDNWVQVMATSGYRLMDKNYPNSDVKYKFDL LNSMLAYFPTENDSNPIFCEVRAELLMLKRDNWMQVMATTNYKLMHISYPSTDVPYKFDQ ------------------------------------------------------------ LNSMLSYFPFENVSNPLLCEIRAELLMLKRDNWVQVMVTSGYRLMDRSYPNAEVSYKFDL ------------------------------------------------------------ FEYALRHELIGHAASAISKKIYAVLKLQQRDCWLRVYSNTDYRVASISIPISGVKYSDHL IDEILKLQIFKDCSVEVAYEICAELKLMQRDTWLKVYSCSDYRLTFKIFSETIIKYDCSK IEYFLNLDIVNKLIEKRLFESRGELKLSQRSSLIKLARENSIEIKGLDQEQVKLDLKHPK IDAMISTGIIANDSSDVSREILADFKIIQRDCWLDAFSSQGFRIDGRAYPSETLQCNLDS IDNYLKLPICNKIMNSEILEFKGELKLAQRSKLAKVANSHGYAINGINESKNTSELSYKP IEYFLSLDIVNKLIEKRMFESRGELKLLQRSSLSKLAQKNSIEIKGLDQKETKLDLSHPK IQQYLALPIVRELFALELVEVIAEIKMAKRFIITKLAERKGFHIEALESPTNLINFSSQE IQYYLHIPIIGKLIKKNLLESRAELKLLQRSILIKLSQINGIYIKGLEQKATPAIMTNLV IDFYLNLPLSQKLIEAEILEYTAELRLLRRTVLGKLAVALGYELPEAGFKGEQISFTYSP VDDFLNLPVAVRLIEHEILEFKGELKMFQRSKIVRIALSKGYRLDGPELPATLTNLSYKP IDLFTNSDTYVSADKTDFYNSRAELVLLQRSALIAIASKNGFSIKGLDDPRNNPPFSYPR IDLMLERLPEGELSDNISLEIKAEFLLLQRDVWLHVFLTTGYKILRKDY-KTEPVYKFDI SNEFLEVSDTIETEGREISEARGELLFACREMLLALAENRGWYLVTAMRPKSEYK-PTEL DKEAAESEDAFQKSFALQTKELLALYSQCNRQRMADILSLEVGLLHYQRKEYTKAVQLLM MEESFRTLGVFYENIIQKTKDLLKEYSSFTRQRVMDWLSIEIAFLYFEQGDYSNCMLILQ LKETFPDEITFQDNFLSLTKEILSLFNMCERQRIVDILSIEIGLLYHQRKEYEQAVSLFL AKSSFKDEETFHANFFNLTKELLSLFNKCERQRIVDILSIEIGMLHYQRMEYERAVMLFM LKETFVDETVFQENFLTLTKEILSLFNKCERQRIVDILSIEIGLLYYQGKKYEEAVSLFL LKETFSDEMVFQENFLNLTKEALSLFSKCKRQRIVDILSIEIGFLHYQKKEYGQAVSLFL ------------------------------------------------------------ LKETFVDEIVFQENFLGLTKEILSLFNKCERQRIVDILSIEIGLLYYQEEKYEEAVSLFL ------------------------------------------------------------ LKDTFSSESVFYGNFLEKTSHLLEIFKECGDRKVVEWLSIQIACLYFQQERYALALKNLR LQNSFKDEETFHQSFLELTKTALALFKKCKRQRVTDILSVDVGVLHFQRREYDKAISILQ LLQAIQSKDSFVDEFTKLTEGILEDFMGCDRSKTIDVLSIDLAILNYEKGDYSECLQILH IKSSFQDSHSFQQSYIDMTKNIIQLLSSCEKYRTVDLLSVDIGLFYLQQKNYTSAISILQ LLEILLNENTYYKHFEKLTELIIHDFVNSGRTKTIDILSIDLALLNYQIGNYQESLNILQ LLQALQNKNAFIDEFTKLTEGILEDFMGCDRSKTIDVLSIDLAILNYEKGNYSECLEILR LLQILKDKDSFVQYFESMTEEIIEDFDKCGRGRTVDILSLDLAAVSYERGDYESCLASL- LVEAMKDKSSYLDVFERLTEDIIEDFLICERSKTIDILSIDLAILNYEKENYCECLQILK LSNELSSQESYEKSFETLTVSAIQDFASCDRIKTIDLLSVDLAILHYRRKEYSEAFDVLS VLEALKSEEIFHNWFEAITEQIIQDMVFCGRSKTIDLLSIDLVLLNYQKGNYQESLNVLQ LKEILKDTASYYNYFEQVTEFIIQDLVVCGREKTIDMLSIDLAFLNYHKGNYEAAIDIIH VKKSYKDELTFQENFLKRTKEILSLFNKADRKRIVDILSIEVGTLYYQMEQYEKAVSIFI VAALLSNEEEFLESYRELTVQIAEEYRHAGRERSIKAFTCDLALLDFQQGRYEQAVTQLK SCNEYYTESKWTVIGVNILEIFVDSLTNCVGIETIDFDGESVPVSTILRNSYLNLYYNST SSYDFYMESGWSVIGSWLLEYYIECIKNCPNITEIDVDGDLVPKSIVLSNSYLNLLTSNS SCYEYYTQTNWNNIGLKILQVFIDSLTHCPELDILEIDGESISASTILSNAFLNILCKDD SCYEYYTQSNWDIIGFKILKVFVHSLVNCPSLKELTIDDEQVPVTTILSSSFLSVITADP SCYEYYTQTNWNSIGLKILQVFIDSLSHCPKLDVLQIDGESVSASAVLTNAFLNILCKDN SCYEYYTQTNWNNIGFKILQVFIDSLSHCPELNILVIDGESISASTILSNAFLNILCKND ------------------------------------------------------------ SCYEYYTQTNWNNIGSKILQVFIDSLSHCPELDVLQIDGESVSASAVLSNAFLNILCKDN ------------------------------------------------------------ LHYENFLDSKWDVIGCRLLELFIKCLHKCPEIEYLETDGEEIPVSSILCNSYLNLLVYSS SCYEFYTESHWDVIGCQLLELFINCLLKCPHLQSLSIDEEEIPVSTILSNSFLNLLASSK DSYDFFIQNGWNYLGGILLEIYYGCMEKTQSTNFEEILSTCLKLLSCLVATDINSLINNK SCHEYYKESQWLQIAVKLLGSFIDCLKTCSVNERLMIDGESIPVTTVLSNSVLDLFTHRD DSYEFFINNSWNFMGGILLEIYLNCTEKLDQSDYSLISLTCLRLFSNLVNYGINNLIKPK DSYDFFIQNGWNYLGGILLEIYYGCMEKTKSTNYEEILSTCLKLLSCLEGTDINSLINNK -THEYYNRNGWDLIGGALLDIYLKCMEKLGLGKKRETLIASAELFSRL-----NSVFGFN DSHEFFIQNGWNFLGGILLEIYYECVLKIEPQDKDEILTTSLRILAVLVTVDINSLIKNK SSYDYFIQHGWSFMGGVLLEVYVECLEKLDMANYTELLRTNLKLFATLKSPGINNLVKNE DSYEFFILNGWNFMGGFLLEVYLDCIEKLNGSDHEHITMTNLRLLSTLIDIGINNMIKTT NSYQYFIESGWTFLGGVLLEVYLHCIQKVNPDNHVMLLDICLKLLASIPSVGINSSIKKK SSYEYYTQSKWDSIGLYILQIFVLSLSKCPNLTTLQIDGDDIEIASLIANSNLEILLSDD TLPSLFSTQGWDAMAVSVFKYYTKCLQALGRKEEL--------LNAVL--LLVSQLITSR SEKKIFWNKFLELKNDDMTELVYPSEDLIDFSVDGNVFLHAPNVYGINVEIKGNFPDVID KNPRKWWIEFLNNNIENNDNLIYPLDNLFLVEITRKVFPVKPNSYGIDISFSKNFKDDIN NDKEAWWKKFIDLQLKNQADLIYPLDGLFEVNLIPRVDITRANVYGLEVDLKNYFPEDIS EEKKIYWKKFVELRRKSQLEFSYPNSGFFDVENIGLVKLYGANEYGIEVTLKDIFIEEVD DSKEIWWKKFMDLQMKNNIHLMYPLDGLFEVTLNSKVHLARANVSAIEVNLKSYFPEDIS KDKELWWKKFMDLQIKNSVDLLYPLDGLFEVIYIPKVHLTRANVNGIKVRLTNYFPEDIN ------------------------------------------------------------ DSKEIWWKKFMDLQMKNSIYLIYPLDGLFEVTLNPKVHLVRANVSGIEVNLTSYFPEDVS ------------------------------------------------------------ SSKQYWWGEFLKLSQIDASNLLYPLENLFTVNISREPYFSKANTYALDVSLENAVPTDIH EAKVQWWDEFLKTNKDTSNNLVYPLDNLFEVNISPTLFLSDANVYALNLEVNSKIPNSIA LQIKKLFDRIEVYANKLDPTKKFSLNQFFKTDILPYISADESDKYLIRLKLKNPFSLGFV ARKSYWWNYFLDINKEANDSLIYPLDNLFRVQVDNELFVTKPNIFALRVDVRSTVPQDIL VKIARLFEKIEEFSGKLNELIEFPLEKIFKVDIKPFIQSDESDKYFIQINLTNYYGIEFS LQIKKLFDRIEVYANKLDSTKRFSLNQFFKTDIIPYINADESDKYLIRLKIKNPFSLAFV KKAKKLYQSILEFEVKIKGPVKFAIRKFFPVKVKPFVYADETNIYKISIEVVNPFHIEIS SQIEKLFKKVDEYSLSQNVKIESSLDDFFKTELIPYINADELDKYIMRLKVKNPFGIGFT NQRRRLFDKICDISSKLDKPFVFPMEELLGLHVSPYIEADPDDSYSVVIKVENDFAVEMK ESISKLYSNILASSLKLDTLLDYPLDNLFKVSIIPFFHADQSDKYFLEFEFTNLFQIDFN PQIEGLFEKMIDCSLHLSETVEYPLQTFFTTKISSYISADFEDRYFVELKVTNLLGIPIT KEKLEKWNSFLELQDNIKVPLLHSVDGLLHINVPKTSYISKPNTYAIKLEVNNFIPSTIE E-----LDEYFKIALSLREQLEFDLTGTFVVDLASGVTHSKEDSVLLEVAINSPLPKAVK VTQFKITMKNSNNEFNEFIERDFLLEMESKSYCLKSKNITFGEFGIESIELCIGSTTIIK ISSITLLMKNYEDEFLPFKIADVILNNDNCIYTLISNSVLWSTFELVALEVVIGSTVFKK TKAMKLTLKNRMGDVIIFETGDMLLKKGKNKPVLECKGVMYGEFSPLSFQITVGGITFVK IDFISLVVKNSMNEQICFNSSQEKFNVDDDKHTLKTHEIIFGEFVPQKLEVSINGTTFVK TKTMRLSLKNMGGDVIVFGASDFLLKKGENKLILECRDIMYGEFSLLSFEIIVEGITFVK TKTMKLTLKNVREDLIVFEAGSVLLKKGQNEPILECKNIMYGEFFPLSFEITVGGITFVK ------------------------------------------------------------ TKTMRLSLKNTGGDVIVFEASDFLLKKGENKPILECKDIMYGEFSLLSFEIIVGGITFVK ------------------------------------------------------------ IHSAELLLKSSNDDFLTFSCKNQVIKHGSNTLTLETTNVRFTTFTFVSFAVTVGDTVFKR VSGITLLLKNNKDEFVTFELADSVIYSGKNKFLLVTTCIIFGTFEFISLELIVGETVFSK FKHVELIMVDEEGSEIVFHAENVEISDKINTIQLSTNNFILGSFSPYRLTIQFNSLFLVL FTTMRLLLKNQNDDLLTFQLSDCLIHPGENEIFLEASKITFGSFELINIEFTVGNTIFCK FKEIKLMLENSEGVT-SFNIENVMISNNVNTLKLYSNNFKFGSFNPSNITVKINNLCFTK FKHVELIIVDEEGSEIVFQADNVEITEKLNTIQLSTNNFILGSFSPYRLTIQFNSLFLIL LSKIKLTLRNAFGEKVYFTCFNKILSASAQTIDLTTRNIVFGEFAVEDLTLHMKNLVLST FKNVELILVDDEGSEMIFQANDVDMSSERNVITLSTNRFIIGSFSPYRLSIQMEKLTLVL IGEIELQLEEETGKTLAFYAENVTLKSVQHEILVTSKVFRQGVFKLVGVVFKVETLHFVH FKTIEFQLVNNDLDELFFVGEDVQILKQVQTFRLVTNTFKLGYFKPLRLTVKVENLEFLK WSSVAIEF-QTSGENITFLRKNVTLTNERQTIKVYSNNFRRGYLSPKQIIVNLEKLQFCE ANSMILSLKNSEDKFMKFTAKDIKIVPDKNEIVLQNKDIFYGSFYPVMLEIVVKNSTLVK VSQVCVTYSYQDGKVIKFESLATTIAPGVNKLQLETNQFTEYPLYPRELVISIDKLSLTI AFEDTTNKVIIEPLFHENNVWFEIRESNELKLGKYELEIADFNFGHTNDLELYLEVGKEV EFDSFETDSKLQPCQSFDAFKVTIEKSIEHICGKTYLRLKFENKEDIDEFTFSIHSTD-- NFLEIQESVVIPEVYCKENTRVLVNQARDLNLGEYALELTTVHCDVLESLQVEIEVQKSA EFINGTLPVNIEAIFDIENVTFSLQQARSLELGEYSLELGISNLDKVEDMRCKLKVNSPN EFPENQDEFVVPEIYCKESTKVLVKQAHNLNLGEYALELKSVQSDALESLQVEVEVQKNI DFSGTQDEIVIPEIYFKENTKVQVKQAHDLNLGEYALEVTSVCSDALKSLQVEIEVQKNG ------------------------------------------------------------ DFSENQDGIVVPEIYCKESTKVLVRQAHDLNLGEYALDLTSVHSDVLESLQVEVEVQKNA ------------------------------------------------------------ IYDSSQANSHLKELYQEDNFRYSIKQSKMALFSEKKLQIEYFNNDSIEEFSLELKALSIE EFDGFKSEHEFQPLYREDSFEVLVQKPGTVHLGMNTLDIEYSNVEDIECFKMQLTVLKTE DYGEKELQMTLLAYQNINKLTAQFCCANDLKLGSTEVVLKIKNGSPIHDVRINLFSTTEG EFAEGDESEQLKQPTDSRNFDVTVLPARHLQLMKNSLTLQYANEAELSEVELVLTIL-PS RYSSENGTEDMFFYQSLSKFSCEFCTPIDIDLESTEIILRIKNGHNVEDVKIDIISNTNG DYGEKELQMTLLAYQNINKLTAQFCCANDLKLGSTEVVLKIKSGSPISDIRIKMFSTTPG VFDA---PIRILIYQDCRKLYGRFRCATQRSLLEKSVLLSLTNGKEIDALKVVITSPD-- DYGQKEMQINILGYQNLNKLTAQFNCSNQVKLGKSEVVLRIFNGDEITDVEIKLFSTTEG GAIDKSESEPFIMFSDPRKFRVVISKPSRIEMGNSSFVLSLENGREIENIHVAISNITPG EYDCVDDPAYIYFYQDLSKLYLELSPSRTIQLGTNELTLAIHNGEDIENISVQLTAVTEG KLSRDGDGDLLLMYRNLNKFWCEFRQPSSLVLGSNAIELEIHNGDDLSKLDITVTFGSVD EFTNNDESKEIIKLYQPSNFSVEVRQSHQFSLDGNSLDVVYHNLKAVETFSVTVDVIPNS DIVSSA---PLYMSSGPGNMNARISVPRELHLNRKCVALTVSNSSSCVDLQSKLYVRDAT TQQATITLDKESLSESKKIKYFFNEQQEQFTLFAKLTYSLQKNPYSISRVIHIDHYLPLS --EGNDSSVTVASFGTFRVPS---ALTTSFFIKTVLSFSKGNEQYIEKSVHEIDYNLPLD SGEIQVKRRLNNLVENTRLEYYLLDQTTAFDLVVKTSFTRKNEQYSETKKVHIECYLQLS GSQVSIYEISDPKKSPILVEYFLNAPTTSFSLQYTASFVRDGVSCKEVQNITVKCYLPIS GNEIQARKRYNTPFENVRLEYYLLDQITAFDLIIKTSFTKKNDQFGETKKVRIQCYLQLS DNEIQVRKRFNNLFESTRLEYYLLDQITSFDLTVRSSFTKENEQFSEIKKVHVECYLQLS ------------------------------------------------------------ GNEIQARKRYNTLFENVRLEYYLLDQITAFDLIIKTSFTKKNDQFSETKRVHVECYLQLS ------------------------------------------------------------ EEGFSLFELCIDDFNQREIIYYTNGTIDRIRLHSLLTFRKGGVNYTQWKPIEINIQLPLA TDDKKIHSVTITDFKEKSVEYFFVNTCDTFTLRQDLSFKKRSTSFEQTKDIVIDCRLPVS LTDLKVSKLDSHESQTFLIPYFVRSVNKIINMRAKIEYKVDNEEYSFQVSYNIDTALTIS NGEGKNHAMTIKGTTASEVEYFIQSPTDQFKLKQEVTFKMTGHDFYQCSIKSISCALPLS LKRLKIMTLSSKESIDIKIPYSYYRDNKIISLKANISYSSNGENFSHFIIDQVDTTLTIS LTELEISELDSQETRTFLIPYYVRSVNKIINMRAKIEYNVDGEEYSFQVSYNIDTALTVS --TFHTDALSPQETKTISVQFRAPENHKRIHFQAQCSYQIEQETFSFQILETIDISLCIS LKKETFEKLDKKESTDILIPYAYFSENKIINMRAKIQYKIDGEDYIFQVSYNIDTTLTIS LNSLSIEKLSPQESWSQQVPFTYYGDTKLLTLNVDVEYVSGEEKFEFHTTLSHDINLDLA LHTFQFDRADTNEIKEISFPYRYHSDNKLLELEVTLQYISNGEKYSFWQRIEVDTTLTIS VKRQQTESLNRKEVKRIPVKYFYTGDSLKLNVSAQISYTVNGETFQYFMDDDIDRSLAVS GKSNLYSISFDNNTKMDNIPYQILDGNTNFTLRVSTNFWKKNDAYSDVTIVKIGCYLPVS LTEIVFENLEKGQVLEVLIPY-ENHGPAIMEFGISIKYRTSEGEYLYDTTDSVDVRLPIS VSVEDIFKKDKFFFKFLLSSVKEEPVLIFGSELQCFELYELSGPFIPDSLTITGTGGESC VSVDDVYLNDRLVFDFSLKSFANEAILIFGTGLETENTYSISEAESFAEVLMNPAVKTPY VSVEDIFKKDIFFFKFLLSSIREEPVILYSSQLSSPDTYKIEGDYIATTELITFDGNESF VSVEDIFKRDLFFFRFLLSVHNDNPIIVYSSKLEN-SGYEIEGNFVPSSVALSSDASESC VSVEDIFKKDIFFFKFLLSSVREEPVILYSSELSAPDTYNIRGDYIATTALITFDGNESF VSVEDIFKKDIFFFKFLLSSTREEPVILYSSQLSAPDTYRIGGDYITTTELITFDGNESF ------------------------------------------------------------ VSVEDIFKKDIFFFKFLLSSIREEPVILYSSQLSAPDTYKIYGDYITATALVAFDGNESF ------------------------------------------------------------ VSVEDIFKSNAFYFKFMVTPSADMPIALHSSSLIVKEPYTISDDFRPTSIPLTADPANQY VSVEDFFKRDAFYFKFLIASSLEQPILLQHIDLISEE-YSIAGGFTPDNLLLKANDNESC VTVQDIFKRDFIYSKFQVTSNPKYPIRIINNDLTTESNYEIIKPSKFPSDIIAFGEQPSN VSVEDIMREGSFFFKFLISSSASEPIVLYRSHLK-PANFSVTGGFEPKTLLLKGSSQETC VSVQDIFKSQYIFSKFQVTSNPKLPIRILSNDLTTKNEYSIISPKH--SRPITFGDQPAS VTVQDIFKRDFIYSKFQVTSNPKYPIRIINNDLTTESNYEIIKPSRFLSDIIAFGEQPSN ISVQDVFKSDLLFSKFQVTVDGNVPIRILSHSLENDN-YEIRGGLQESS-VVVYDEKPAS VTVQDLFKQDFIYSKFQITSNSKYPIRLLDNELTTEADYKIIRPGKQGHDVVAFGEQPGT ISVQDIFRLHSLYSKFQIRANGGNLVRVLDCSFESPDGYEISSPEQKFELLV-FGEQPAY VSVQDLFKNSFIYSKFQVTSNPKLPIRVMDNKLSTANSYSISHPCC-GTSLVAFGEQPAS VTVSDIFRESFFYSKFQVTSNAKFPIRIKDVTLTSDSTFDIQVPSKSYDSVVAFGEQPVS VSVEDVFKKDMFYFKFHLSAIEKEPILLCSSKLSPPKDYSVSGNFNPKTLCLSFDSNNSC VSVQDVFRTSFLYSRFSVSTDAS-PIRTLGVTLSESDGYAISTPSMSSD--VVFTNQAAS ICFQISTKQTFNNSDIFHLMIKYCTLRDFLKSYVTDAVLLEGDFQKYETWKLYWLSNILS HYFQILNKQGFSPVDKFRFSVKYLRVQQYFGELVQKIIPPK--EQNIVDYNY-WQNYIVP ICYQITANVNFDSKDIFNLKVRYNTLKEQLDCFVTDAILIEGDFIGFEKWRTFWELEILK FCYKIRPKEGFDSQDKLSLKVKYNTLKEKFDCLITDAVLIQGDFRQFEKWKLFWETKLLT ICYEITANNNFDSKDIFNLKVRYNTLKEQLDCFITDAVLIEGDFILFEKWKTFWELEILK IFYQITANGNFDSKDVFSLKVRYNTLKEQLDCFITDSVLIEGDFVKFEKWKTFWEFEILK ------------------------------------------------------------ ICYEITANSNFDSKDIFNLKVRYNTLKEQLDCFITDAVLIEGDFIHFEKWKIFWELEILK ------------------------------------------------------------ LYYQVKVSEGFDPADLFELYVEYNTLKEELDHFISISIFKNNESNRLEQWSLFWGHTILP LFYQVQTFEGYNSKDIFHLEVTYNTLKEQLDELVTGSILLQGDSTNFEPWKAIWEDIVLP FFYKIKPKSNVYLNDTLSLKVDYTNLQEECEEYVSQEIIHQLERIKLVKYWYLIKDVIVS LFFQIKPKNEVESNDFFQLEILFSTLKDQLDHLVTNAVLIQGSASKMDNYKDIWNSNVLA YFYKIIPKSDIKSLDSLDLRVEYSDLKNECYDIIQSFLLHRLQDLQLRKYWFLIKSLLFK FFYKIKPKSDVYLNDTLNLTVDYTNLQEECEEYVSKEIIHCLEHNQLVKYWYLIKDIIVT LIYRIRATDEKLAKESLKLSVKYKSIKEEAGEALAGLVRQHLVELDMLKYWLLLQDTILH FFYKIIPNNIVSSEDVLNLKVEYTNLKEECEDYISEVVISQLTELGLSKYWYLLKDIIIN MFYRVRPKGDMAPSDTLDLTITYSDLHQECERALFEKLRMELCEAKLEQYLHVIQSELGP FFYKIIPDSGMVSTDTLELKIEYSNLIDECYHFLKLQILPELKELGLERYWFIFQNLVGK YLYRILPTATNFQVEKFDLKVTYSDIRSECLLSLQKRLIGEFKSLKLDHYWFLIHSILQD LCYQIKSSGIFDSNDIFDLTVKFNSLKEQLDILVTDAILVQGDYEKFEQWKIFWEQDILS FTFRIEPRDWFIAAGPLTLRIEFRRVADELVEFIWAKITAKLAAAGLEDCIVSLR-VIKS ELEFDYNLYEKNMILKLNGQSLDIFKVGVRLKYMKVDPVVRSKFLSCLKRLSEGIDLKVF NLKLSDKAFESSRKVAIILEEPNILES----LELIGSSAFKVQIKSILKKLKSGIPITAS ELKYDYDAFKENRIIKSLKASIDLNKINSRLLKLSMEKTVLDKMLRCLNKVGRGVAVRNL QLSYDYKIFEEQSILKFTEST-NISKFCKLLKEIPMEASVQRGMFECLKRVSRGIKMKNL KLKYDYDAFKENRIIRLLKTSIDLNKTKSKIRNLCIEKAVLDKILICLNKVSRGIAVRNL KLKYDYDTFKENRIIGLTKASVDLNKIKSSLLKLSIEKTVLDKMLTCLNKVSRGITVRNL ------------------------------------------------------------ KLKYDYDAFKENRIIRLLKASIDLNKTKSQIRKLSIEKKVLDKMLICLNKLGRGIVVRNL ------------------------------------------------------------ QLVYDYAYFNRTRVVKILNEVQLLL---NDLSSSISDSEILNRYGSYLKLLASGIEFSSI KLYYQNQLFEKKNIIKLAANKSYLEEIIEHLKAQVSAVDVLERVIKCLHSILTGVTMKNM KLTFDLNGFAVYKTIRFLNGLELNLLAERIILQYVESSVDQKNLVKLMSNLLVNHNFYNN ELAYDYSLFETEHKIKLNSPRESITLMWRHLHSRIKDEDFMEALKRCLLELKNGFQLKDI DISFDLNNYAVNLEVRIINNREIELLIEKALLKHIEETEDKKKLIELFKHVLFDNEFPNF KLKFDLNGFAVYKTIKFLNGLELNLLAERIVLQYVENSVDQKNLLKLMLNILVNHNFYNN QAQLNLIRFSTSNVVEITNKHSLILLAERVIVLHVDSEATQKTLIELLETITAKSEKSDG KASFDLNNYAINNFINFTNGLELNLLSEKIILQYVESSSDQKKLFNLMNQLLVDNKIRNS -LDFDLNHYAFHDTVILKNASSCSKKADAGLSAVVRESSNREVLQEILAKLATNI--RFS KVKFDLNNYGIKQFIKILNGVELGLLLKLLFLRHVEKKEEQDKLVQLMDSVLADKVYPFP SLRFDLNHYAIYREVKVLNHNETLLFAAKMANKYVPFEHLQQQLVKVVGDVISDQWLPGD QLYYNYMEFQKNRKIILLPNTLDIQKFQQRLLSFAIDVSVIRRIITCLKSIEKGVTLKNM LIEADVTSYALR----LPTMSEPIVLPEWTEALQAVSKDNHEKVKEVVNEALAESTSCLL NVKTLTVPVQLPELERFYEVSFARQQTPNKVGEPLAFHIKIKNSSKWGIQRHDKLYTFEI MLHELVLPVNIPTLSLFYSVHFRQINKELKAGVPSSFKIEITNLSTWDLQESQENAILTI VPKQLTVPVQLPGFEQFFRVRFHPINPMVTLGCPIQYAVVVENLSQWGQDAINDGFILEI CPRELIVPVQLPEFEQLFSVELSMLEGSLTIGTAVPFDVKVENLSQWKHPRLESDFVFEI VPKQLTVPVQLPGFEQFFHVQFEQMDTIATIGNSLSYTVIVENLSQWGQDVIDDGYIFEI VPKQLTVPVQLPGFEQFFCVQFKSTDVMVNIGSPISYAVLVENLSQWGLDIIKDGYIFEI ------------------------------------------------------------ VPKQLTVPVQLPGFEQFFHVQFESMDTMATIGNPVPYIVIVENLSQWGQDIINDGYIFEI ------------------------------------------------------------ QPNTLIVPVHLPSIKQLFSVRLSATHEVLHVGDAVTIDVEVCNLSQWVMEREPLTYIVEF TPRRLRVPLTLPLLRQMFFVELKNEEKVPQVGEPIPMTICVANLTRWDTEAVHGDYSFEI VLH-LHISVPVPVLKYLQIVEYEYDKKQYTVGEPINVNLKINTVTRWCPKDRDREFQLVI EPSTLVVDVNFPLPSKFFSVDLRSAGDTPEVGQSLQFRVRIYNADGWGSNGTEVPYVFEI ENKQLIISVPIPVLNILQIIEFEFEKPQYLVGEPILMNLKIESITKWSNNKVKAGFQLSI VLH-LHISVPVPVLKYLQIVEYQYDKKQYTVGEPINVNLKINTIIRWSPKDQDHEFQLVI SFEVLTIDVSVPSLQYLHTIEFQTPEKVVMVGDPFLVKLSIDCTTRWKNSQGANSFVLEI --HFLYISVAMPILKYLQVVEYEYERKQYVVGEPIKVQLKVKTITKWSDDTKSNEFQLNI RKHQLYISVAVPFLSMLHQVEFQFEKSQYFVGEPIEARLCIDSSPKWKSTDVPSPFHFSV IPRILHISVPVPILRYLQILEFHYDQPQYIVGEPIPMRLKVETIQKWHESDSLPDFLMFI ELRELRIAVPAPSLDVLHSATFEYEKSQYLVGEPIEIKLTINTISSWALEKSGLEFQASL ISKQLVVPVTLPEFEEFFYVEFFKEKETLKIGESVKFKIQIKNLCQWSQCESQGSFCFEI PSQFLCISVPVPQVQIVLSSKLTEDTKPQRVGEAIDYTLNINSKL-WDSNLAPDTFFYEI INNNDWLVHGRKRMILKDDFEEMDIDLIPLRKGYLTLPQIEITSSVGNPVRVDNSNTYDI ANNSDWIIGGKRRFELDTKRIDATVNLIPLRRGYLNYPSIELTLNGERTGQMDYLASNDK LSSNEWLIHGQKRGAIKERQMQFEVYLIPLRKGYLNFPHVEVTNIYGKTCRVDHSNAFES MTSNEWLVNGKKRVGLNSEDTEYQVSLIPLKKGYLSFPRVEITSADGGGARIDYLNAYET LSSNEWLIHGQKRCAIKEKRKEFEVHLIPLKKGYLNFPRVEITNINGKSCRVDHSNAFES LSSNEWLIHGQKRCAIKERQMELQVYLIPLKKGYLNFPHVEITNLSGKSCRIDHSNAFES ------------------------------------------------------------ LSSNEWLIHGQKRCAIKEKRMEFEVHLIPLKKGYLNFPHVEITNINGKSCRVDHSNAFES ------------------------------------------------------------ SNSPDWSINGRRRSVIVGDHLVFSIQLISLRRGYLIYPKAEIYNEKDKVVEVVHIYQRDK LNSNEWLVSGKRKTTITSALLEFKIHLTPLKRGYLRYPKIEITQKAKKTFEVDYLNLYET QQDDNWLMSGFKRFTFNGGQETKQLTLIPLTVGKIPLPQVSIKDDDSDDIDIEFINGSET SNTNEWLIDGRRRFSLQPEVDQYPIKMIPLRRGYLRYPKVEITEGGRKIPDVHYTNAHDS QTDDNWLISGFRKESFQIDYVAFEVVLIPLTVGRLLLPKINVRLENDFSMDINFKNGLET QQDDNWLMSGFRRFTFSGGQETKQLTLIPLNVGKIPLPQVVIKENDSDDLDIEFINGLET VQTNDFLLDGMSSCVFSVSNSGYELTLIPLTVGKVKFPRVNVITADIAYSDTHLINAQEV QQDDNWLMSGLRKFNFDMNSKDAELMLIPLNVGKIPLPKVSIKNKDDDDLDIEFINGSET VQEENWIISGFKKQSFEIDESGFSITLIPLNVGHLQLPKVFIRSAQEQSMDVVNENALET QNDDNWLVSGFKKYNFDVKGHRVDLVLIPLNVGKLILPKVIIKNEDDSSMDIEFKNGLES LYDENWLISGFKREIFEVDYSTFSLVLIPLNVGKLELPKIGIKQEQEISMDTILKNGSET TNSNEWVVHGRKKLRFSTPEEEIEVSIIPLKKGYLTLPKIEITNYKGDLTRIDNPNAYET LPPDTWTVYGRRKGHFVADNVVENLQLVPLKTGRIALPEVVIRSETPISMEVDNRIGVKY VLVFMR-WSQLALFSIFSYITLLRLTDVNVINYTDLLTFKEVSADIVTDIEVTIDAIYLV LLIFMRVQSLILSALTFVQYCIIVLKDAVVAFDSEVVQLNNIDSKYDSKVPVSLSETLKL ILVFMQFFKQLAIFVACITFALYVAQDVHISFPGTSMMIGKIGPGGKDDITVNNNQVIEV VLVFMQLSVLSVAALAFLQPAVFKVEDARVS----DIDLGTIDSSFSPLIAVTKDEEIEF ILIFMQFFKTLAALVSCISFVLYVAQDVHVSFPSTRVMIGKVEPRGIDEITVEDNEVIQV ILVF-------------------------------------------------------- ----MQFFKTLATLVSCISFALYVAQDVHVSFPSTSIMIGKIEPKEVVGVTVDSNEVVQV ILIFMQFFKTLVILVSCISVALYVAQDVHVSFPSTSVMIGKVQPKGTDGIAVDNNEVIQV ------------------------------------------------------------ IFV-MRFNSVLCVLGGALSVAAFSVKDARLRFPHADLALGAASGTLKKAVTLGADGEVRV ILVVMQLVKILAGVSVFASTAFFTAKQPYFTFATSSLALHPITKGFEKQVVIDINENLEF ILVFMKTSVFIAIFNLLVCALAYTDLTGSIKINDKKITLGEFNTQEVKQLTINSKDIIEI ILV-MLFARIALNTLAGATAALLSVKQPHVSFTEAPVALRPISSQFKKAIIVQQNETLEF LLVFMKLFASIVIFLQLFAVSWFSISKGSIKSNGESVAFGEMNTQEIKKLSINSKDKIDI ILVFMKTSVFIAIFNLLVCALAYADLTGTIKVNDKKITLGEFNTQEVRQLTVNSKDIIEI LTVFMIFSNIIVLLALAFHAIAYGPVVGSISINGKAVHFGEIETQEIKVLPLDSKDVIEI ILVFMKYSVFIGLLSLFTFSLAFSDLTGTIKLNGRKITFGEINTQEVKQLSIESKDVLEI VLVFMKLSVYIPVSWILLAASTYSVEHFGLSLNSQKLYNAKSLPSEVIRVGIEKKDALTF VLVFMKLSIIVAVICQLGAAAMYTISEGSIKLNDQSVFFGEFMTQEIKHLSVDSKDKIEI LLVFMKLAFLLGVVAQLAMGVMYSIQSGLARVNEDIVQYGEAEIQSIRSLTLENKDKLDV FLVYMQFSKVLVIFIALFYQSLFSISNGKINFPGSAISIDKFDTKNSKGVTVKDEEIIEF VVVFMNPLRLAAIASTVALAAAWAIKDAKLTVSARTELVSLPFTNEAVD-AVVPEASLDI TFKS--ETPLDQANVYLGHDKSLEVVYPIKERAGDYLFEINMDKLDKNLLANKPLAVTVV SFVV--DQELEQANVLVGLSENLEAGYTLK-KQSGFSLAIPLPKLAHAFNDRAELQVNLL NFAIDSSDKPFQNSLLVGLDNNLEMVFEPEIKDNGYKYKIDLATLDAALLQLEPIQATLI QFTLNQEEEPAQISLLLGNDRHLETAYTPEVTIAKCKFTIPISQLKPALLNNDFLTASLI NFAIESTNKPFQNTLLIGLNKNLEMAFEPEIKDNGYKYRIDLAKLDAALLQPEPIKATLI ------------------------------------------------------------ NFAIDSNDKPFQHTLLVGLNRNLEMAFEPEIKDHGYKYMIDLATLDDALLQLEPIKATLI NFAIDSANKPFQNTLLVGLNKNLEMTFEPEIKDNGYNYKIDLAKLDAALLQVEPIKATLI ------------------------------------------------------------ ELAV-DGPAPEQASLMVTAQHAVDWVLPRAAERPAHSFVLDVAELPRELVAGEPLAVSVI DFSVDSSEVPERVTLLLGSEHNVETSYEPVVRSSDYKFKVPVSRIPSSLLYQEPLYVSLI DLKSDIKGKPEQIMVSLADNPAISTHYVPVVKESKIKLNIKALSIPEVLKTKDKLVLTIV NFVLEAADKPQQASLAVGSARDIEIHYSPIIKDNDYKFKIPIERLPESLLYKEPLTASLI SLNLDFSKAPNQIVVSLGNNKGLDSSYVPKFDASSISLSIPVKKIAERLKIEDKLFLNLI DLNSDIDGKPDQIMISLADNPAIVTHYVPVVKESKIKLNIKALSIPEVLKTKDKLVLAIV KLKDSLQGQPEQILFTLADKSSVATHFVPVVKGKNINLSIPASSLPDVLKIKDTLVLSLI KLKSDVDGKPEQIWVSLADDQSIVKHYVPTVKKSDITANIKASTLPDVLKSKDKLVLSIV TIKLASSERPHQSILLFSDEKGLDYAVFPDYNAQKLAIQIAVSSLPTALVRQGKITASLV SLQLVLDKRPQQLVLVLSSDSALAAHFVPGFTSSSIKFSLPASKFPEVLKIKEKLNLKLI ELKLDVTKKPHQFVITLGDDNGHDLSFVPNYLSAYYKLSIPVNKIPLSLRVKDKLFLKAI GFSISNSDNAIKSHLLLGFRDGLETVIEPLVQKKDYLFNIRLNALSKALLSQESLEATLL VFFTGKSAVPHQSMVIIADESGLEASYPVLVRPNGAKFAIPHSRLPQALVAQRPLDVKVI AASKDDSEGVLKTLFYMQLQESMLEELPQRELAKKELAHTFNKPPTHAPKLFAQLFALII VST--EENSLVKELFILSIVDPVTARNFVRLNPKEEIHHIFQSSPKTVNAFIAQLFALVI LASAKPKDNLFQKVFQLDLDFDLDLSLVDKFNIQPEIRHVFHTEPKRVAKPIARIFVVII IADNTHNENIFVSVFKLDLQLPESYDSPERFGPKKELRYTFAEPPKTVNSMLALIVVSII LASAKPKENLFREILQLNLNFDVDSSLVDKFGIKPEIHHIFHAEPKRVAKPIAVIFVLII ------------------------------------------------------------ LASAKPKENLFREILQLDLSFHLDSSLVDKFSIKPEIHHVFQTEPKRVAKSIAVIFVAII LASAKPKENLFREILQLDLNFNVDSSLVDKFSIKPEIHHIFHTEPKRVAKPIAVIFVAII ------------------------------------------------------------ LASPGADGNVFAELFDLDVGPV--SADVPSVGKLPEIRHVFNQQPKTVAPFFALVFCVAV LASGAGDSNVFVELLDLKLDFESGLKLPERFGSKPEIHHIFNGSPKTVSPWLAQFFCLVI IADSKSKNNMIRRLVEVLPSPEFKYQAKPRIGIQPEIHHIFREDERTVNPIVPVVFIIAA LASDGGENNIFVEVFDLDLAFDTELSLPPRFGKLPEITHTFNSAPKTVSAWFAQVFCLIV VGDSGSSANLFKSLVEIIPTEELKYTEVERNGIKPEIHHQFREDPKTVNPLIPLVFIGGA IADSKSKNNMIRRLVEVLPSPEFKYQAKPRIGIQPEIHHIFKEDEKTVNPIVPVLFIIAA IADKQSTKKVNKRLLEIKPSRELKQETVPTFGLQPEIHHIFKEDEQGVNPVVPVAFILVA IADSKSKDNLLRRLVEILPSEEFQYQQKPRIGIQPEIHHVFRGDEKTVNPLIPVVFIGIA IASDDVNENIHTKVAELTCSDELREKQAERFGVLPEIHHIFKQDESTVNAIVPLAFSAVA IADASSGKNLVKQLVEIVPTEEFRYHEKPRIGYKPEIHHIFRTEDKQINAIVPLVFIGGA VASKKHGENLRRNLAEVRFGDDIKYVPAERFGLKPEIHHQFASEASTVNAIIPIVFSAGA LANDNKNNNIFGRVFQLTLSPDLEYTKPSRFGFKDEIHHIFRSPPKAAPAFIAQVFSLAI LGSTKGSETVVARISPEASEESKKYKKAVRHATKPEIKHVFRPAARQVNASVATIFSAGA LATFAALVITWFAAGANFGNMPKG-NFIYFIGFVVTIVGFEYIFTQYQLGTGIFETINRA TTTLFVLFVSWVSFGANFN-----LKNVSSYLFVALVSGFEFIFYKYYSGTSIFDTVFST FFTILSLLVTWVNSCAAFDNIPTGANALYFLGFVATIIGFEVIFARYYLGTSIFETLFSS VVSTFALVITWVSSGSSFNNLPADIDSIYFLGFLTSIVGFEYAFVQYYLGKSIFDTLHVS FITILSLIVTWLNSCAAFNNIPTGVTAVYFLGFIATIVGFEVIFARYYLGTSIFETLFSS ------------------------------------------------------------ MITILALVTTWLNSCAAFNNIPTGTNALYFLGFIATVVGFEIIFARYYLGTSIFESLFSS VITILSLIVTWLNSCAAFNNIPTGINAVYFLGFIATIVGFEVIFARYYLGTSIFETLFSS ------------------------------------------------------------ AACVVPVVGVWMATVGVSNRAPAG-SPLNSVGFLGAIVAAEVTFARYYLGSSIFTTLAAS AASLFGLLSTWAMSGAGFDSLPSGMNLIYLLGFVGALIGLEYIFTQYYLGASIFVTLGNT FTLLLGLFGSWVGFIGLFRTFKSKVQLLHNVSFLISVLGFELNFVKYYLGQSIFTTLFYG VGCVLSLLLLWLNCGISSLSLPNSLVSLYLLGFVGSIFGMEYVFTQYYLGTSIFKTLENA TALFFGLVVAWGTMIGLFGTFNSGCKVVYNLGFLISLVGFEFTFIRYYLGATIFVTLFYA FTLLLCLFGSWVGFIGLFRTFKSKVQLLHNVSFLISVLGFELNFAKYYLGQSIFTTLFYG VALHLALLASWVGFIGLFRTLNSSSQLLQNISFLLSLLGFEVNFVKYYLGQSIFTTLFYG LTLFVGLVGAWFGFIGLFRTFKTTTQLLYNVSFLISLVGFELNFYKYYLGQSIFTTLFYG GVLTLVLFVVWSSIFG-----NNSSGGTYKTGFLVALVAVEHTFLRYYLGASIFTTISHV VVLFLALIGSWFGFIGLYGALKSGGQLLFNIGFLLSLIGYEYNFVQYYLGQSIFTTLFNG IVLLLALLVSWASLLGLLRNFTSGAQVLNHGVFLTALVGYVAVFYRYYLGTSIFTTLFNA AGCVVLLIGTWLSTGVSNMCIPGGMNSIYFIVMISSIVGFEYIFTNYYLGVSIFETLHAG VAIFGALLVAWTALIGLLGQASLKAAPLGYIGLLGSLVAFELVFVSYFIETSIFTTLGAV ICLGVPGIWISAKFLRSVEKPL-------------------------------------- GLLFLPALLLGSATLKSLKQ---------------------------------------- LYLGAPGLLASTKFLRYFGQTI-------------------------------------- FYLAALGLWIGTKFLRTFGKTI-------------------------------------- LYLGAPGLLTSTKFLRSFGQTI-------------------------------------- ------------------------------------------------------------ LYLGAPGLLMSTKFLRSFGLTI-------------------------------------- LYLGAPGLLTSTKFLRSFGQTI-------------------------------------- ------------------------------------------------------------ FYVAVALLYFGSRTLRCLPGGQ-------------------------------------- LYLSIPGIWLGSRVLRYLTKRA-------------------------------------- FILSIPCVYFGVSVLRSLAKNR-------------------------------------- FYVCLPGFFIGCKLLQSLS----------------------------------------- FVLGGPSIYFGSRVFRDLAKYH-------------------------------------- FILSIPCVYFGVSVLRSLAKNR-------------------------------------- TILSIPSLYFGRSVLRALAKNR-------------------------------------- FILSIPCVYFGVSVLRSLATNR-------------------------------------- LLLVAPSVFLGSKALNVMAKSR-------------------------------------- ALLSLPCIYAGARVLKNLSRSR-------------------------------------- FVLTAPTIFFGSRSLRDLAVFR-------------------------------------- LYLIIPSLIIGTKFLRNIGKQI-------------------------------------- SLITPVAVVSGVSALRELHERR-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MRELLV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MIRMNLTLAIRAAHRTQNRC ---------------------------------------MNSVLQPLITPQYRCTPFVLR -----------------------------------------MLSVCSRIRKYVPSSLCRI -------------------------------------MFPISIASHGLPNSPLLPLLIKL -----------------------------------------MILVYNRIRSIISSSLGRI -----------------------------------------MLLVYSRIRNNVPFSLCRI -----------------------------------------MLLVHNRIKSNKFSSLGRI ---------MSASNTDRKFQPSGKAYRSESNDYTYGRESYIMLLAYNRIRSIVSSSLGRI ------------------------------------------------------------ ----------------------------------------MPVQGLPSVSITPMRELLRG ---------------------------------------MNAKLLLWDSSLIRQLLLSRQ ------------------------------------------MNSLSIKFRNRHCNNLLI ----------------------------------------MIIRVSLQPHLRPLTSLSRI ------------------------------------------------------------ ------------------------------------------MNILSIKFNNLYSNNLRI -------------------------------------MTLVLDNMIQRTYQLHPSQFGLV ------------------------------------MILFKLPHHITAPIHFKRFKSDKS VRKNLSVLVDEHRLPEDAGPHIIRMHLAEILPTIISIPRSGNPMSRSFFSFKRGNVVSPL -----------------------------------------MYIAVSRCLRSETQGDIVN ---------------MHILGQFCNRVGNGTSYGRGVHAVKIHLYTSYSGTSKHCQLNVQI ----------------------------------MQAWLYKSLNSKFCRIPVNKNWFRLI -------------------------------------------MRQKLPFNPLQSLLPRI YSRA-------------------------------------------------------- LVRY-------------------------------------------------------- CIRY-------------------------------------------------------- QVRF-------------------------------------------------------- HVRY-------------------------------------------------------- CIRY-------------------------------------------------------- YIRY-------------------------------------------------------- YVRY-------------------------------------------------------- ------------------------------------------------------------ FCRF-------------------------------------------------------- FVRC-------------------------------------------------------- FARN-------------------------------------------------------- FVRY-------------------------------------------------------- ------------------------------------------------------------ FVRN-------------------------------------------------------- LRRF-------------------------------------------------------- LKNY-------------------------------------------------------- FVRW-------------------------------------------------------- FIRY-------------------------------------------------------- RSKS-------------------------------------------------------- QLRY-------------------------------------------------------- FVRG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ---------------------------------------SSKRWL--------------- ------------------------------------NSNAQNRWL--------------- ------------------------------------NSGSQNRWL--------------- ------------------------------------NSNSKSRWL--------------- ------------------------------------NSNSQNRWL--------------- ------------------------------------NSNSQNRWL--------------- ------------------------------------NSNSRNRWL--------------- ------------------------------------NSNSQNKWL--------------- ------------------------------------------------------------ --------------------------------------NSSGRWL--------------- ------------------------------------NSSAKNRWL--------------- ------------------------------------------------------------ ------------------------------------NSSSRSRWI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------KSGTSSKRWV--------------- ------------------------------------KSKSSTRWL--------------- -------------------------------------SVSSERWL--------------- ------------------------------------NSNSKSRWL--------------- -----------------------------------KKHDARSRWE--------------- --------------------------------------------DRQK---------QDF --------------------------------------------ARQK---------NDH --------------------------------------------NRQL---------GDP --------------------------------------------DRQW---------SDP --------------------------------------------NRQL---------KDP --------------------------------------------NRQL---------GDP --------------------------------------------SRQQ---------GDP --------------------------------------------NRQL---------RDP ------------------------------------------------------------ --------------------------------------------SRQR---------RDP --------------------------------------------DRQR---------NDF -------------------------------------------KSKQNVRKYIDSVSNDT --------------------------------------------DRQK---------NDS ------------------------------------------------------------ -------------------------------------------KSKQNVRKYIDLVSNDT --------------------------------------------KSKQTRKHLAKVQDDP -------------------------------------------VNRVQ---------GDS --------------------------------------------ARQM---------DDA --------------------------------------------NRQV---------NDP --------------------------------------------RRQK---------DDP --------------------------------------------QRQW---------SDP --------------------------------------------MRQM---------KDK YTRESKLD-------------------NLRS----------------------RAGF--- FTKAAKEQ-------------------QFRS----------------------RAAF--- YTKKAKVQ-------------------NLRS----------------------RAAF--- YTREAKIN-------------------NFRS----------------------RAAF--- YTKEAKVQ-------------------NLRS----------------------RAAF--- YTKEAKVQ-------------------NLRS----------------------RAAF--- YTKEAKVQ-------------------NLRS----------------------RAAF--- YTKEAKVQ-------------------NLRS----------------------RAAF--- ------------------------------------------------------------ YTREAKVQ-------------------ELRS----------------------RAAF--- YTKEAKNQ-------------------DLRS----------------------RAAF--- YSNKRRQS-------------------LFKS----------------------RAAF--- FTRDAKVQ-------------------GLRS----------------------RAAF--- ------------------------------------------------------------ YANKRRQS-------------------LFKS----------------------RAAF--- FNRRKGDF--------------------YRS----------------------RAAF--- FVSQRKTS-------------------LYKS----------------------RAAF--- HTKKSKAE-------------------GYRS----------------------RAAY--- HTKQSKSD-------------------HYRS----------------------RAAY--- HTKEAKKQ-------------------HYRS----------------------RAAY--- YTQEAKDQ-------------------NLRS----------------------RAAF--- HVAMAKAD-------------------GFRS----------------------RAAY--- -----------------------------KLA---------------------------- -----------------------------KLM---------------------------- -----------------------------KLM---------------------------- -----------------------------KLT---------------------------- -----------------------------KLM---------------------------- -----------------------------KLM---------------------------- -----------------------------KLM---------------------------- -----------------------------KLM---------------------------- ------------------------------------------------------------ -----------------------------KLI---------------------------- -----------------------------KLI---------------------------- -----------------------------KLQ---------------------------- -----------------------------KLM---------------------------- ------------------------------------------------------------ -----------------------------KLE---------------------------- -----------------------------KIL---------------------------- -----------------------------KLE---------------------------- -----------------------------KLI---------------------------- -----------------------------KLI---------------------------- -----------------------------KLI---------------------------- -----------------------------KLI---------------------------- -----------------------------KLQ---------------------------- -------------QLDDVYHVF------HKSVPQRILDLGYAPGAWSQV----------- -------------DIDDKYRFF------KQ--NQKVLDLGFAPGAWSQV----------- -------------QIDDKYRLF-----SKSKPEQRILDLGYAPGAWSQV----------- -------------EIDDKFHIF------NKSKIQRVLDLGFAPGAWSQV----------- -------------QIDDKYRLF---SKNRT--DQRILDLGYAPGAWSQV----------- -------------QIDDKYRLF-----NKNKSNRRILDLGYAPGAWSQV----------- -------------QIDDKYRIF---NKNTP--NQRILDLGYAPGAWSQV----------- -------------QIDDKYRLF---NKNKS--DQRILDLGYAPGAWSQV----------- ------------------------------------------------------------ -------------EIDEQFRLF------RA--GQRVLDLGFAPGAWSQV----------- -------------ELDDRFKFF------LKNKSQRVLDLGFAPGAWSQV----------- -------------EIDSKYRIF-----TKR--TKNIVDLGFAPGAWTQFAVHRL------ -------------QIDDKVHLF------RKNARQNVLDLGYAPGAWSQV----------- ------------------------------------------------------------ -------------EIDKKYKIF-----TKK--TKNIVDLGFAPGAWTQFAVHRL------ -------------EINDRCRLF-----HKN--CKNIVDLGFAPGAWTQVAVEK------- -------------EIDDKLHIF-----KNG--TRNIVDLGFAPGAWTQVAVNRL------ -------------EIDSKFRLF-----NKN--TRNIVDLGFAPGAWTQVALARC------ -------------EIDQKYSVF-----NRK--TENILDLGFAPGAWTQVAVERM------ -------------ELDHKFSLF-----KRN--TLRIVDLGFAPGAWTQVAMQRM------ -------------EINNRFKLF------DKHKKLNVLDLGFAPGAWSQV----------- -------------ELDSMFRLF------KP--GMTVVDLGFAPGAWSQV----------- -------------------------------------------ARKRTHPDSI----VLG -------------------------------------------ARKRIGSGGM----IMG -------------------------------------------AHQRSSPSSM----ILG -------------------------------------------ARERTSKESM----ILG -------------------------------------------ARQRSSPNSM----ILG -------------------------------------------AQQRSSSNSM----ILG -------------------------------------------ARQRCSPSSM----ILG -------------------------------------------ARQRSSPDSM----ILG ------------------------------------------------------------ -------------------------------------------AQQRTQPGGK----VMG -------------------------------------------AFDRTKPNGM----VLG -------------------------------------------EEQNLSHN------ILG -------------------------------------------AFDRTGPDGV----ILG ------------------------------------------------------------ -------------------------------------------EEQDQPHK------ILG -------------------------------------------LHEQKIEDFK----ILG -------------------------------------------ESKNLPYN------ILG -------------------------------------------KSKNITPR------ILG ---------------------------------------------KKLGVKSL----ILG -------------------------------------------AQLGQKPK------ILG -------------------------------------------IRKSTSDDSL----ILG -------------------------------------------AAQRVRPGGR----VIG VDILPC------DPP--------FGVSSMQANILSKRTHQLIRQFFMEQIFMNDSQV--- VDLLRC------TPP--------KGVYSLQANILSKKTHELIRLCFARHIQLNKHDQ--- VDILPC------EPP--------HGVNSIQANILAKRTHDLIRLFFSKHFQLNKHDE--- VDILPC------DPP--------HGVSAIQANILSKKTQMLIRLYFTRHFKLNRIDK--- VDILPC------EPP--------HGVNSIQANILAKRTHDLIRLFFSKHFQLNRHDD--- VDILPC------EPP--------HGVNSIQANILAKRTHDLIRLFYSKHFQLNRRDE--- VDILPC------EPP--------HGVNSIQANILAKRTHDLIRLFFSKHFQLNRHDE--- VDILPC------EPP--------RGVNSIQANILAKRTHDLIRLFFSKHFQLNRHDE--- ------------------------------------------------------------ VDVLPC------KPP--------TGVSSIQANALSRKTHELVRLYFSRHFQLNMHDE--- VDILPC------KPP--------RGVSSIQANILSRKTHELIRLFFSKHFQINRHDE--- IDINLA------TPV--------KGCHYMQGDIMNKSTHAKIRNFFEK------------ VDILPC------APP--------RGVSSIQANILSRKTHELIRLFFSRQFQLYYEDR--- ------------------------------------------------------------ VDINLA------TPV--------KGCHYMQGDIMNKSTHAKIRTFFEK------------ IDINEA------VPY--------RGCHYIQGDLLKKETHEKIKEFFKSKDGSP------- VDINPA------SPV--------RGCHYIQGDVTKKSTQTKILEFFKR------------ VDLINC------SPP--------EGSSFLQGDIFSKKTHSEIVNFFDPEGHS-------- VDLILS------TAP--------KGSHFIQGNILSKKTHDDIRDFFTR------------ VDIIPS------TPP--------EGAQFLHGDIFSRKTHQEIRDNFPN------------ VDILPC------DPP--------TGVSSIQANILSKRTHDLIRLFFNESFQLNREDN--- VDILPC------IPP--------PGVSSIQGNFLSKETQNELKRVLAVSAMG-------- ---------------------------------------------ESMARNDSDTEQQPQ --------------------------------LHKDHGYLQHMLEEELNHLKETEEYKEL --------------------------------LHKDHGYFQNMLEEELTHLKDTDLYREI --------------------------------LHKNHGYLYEMWEEELLHSKDTETYKEI --------------------------------LHKDHGYFQNMLEEELTHVKDTELYREI --------------------------------LHENHGYFQNMLEEELTHLKDTELYREI --------------------------------LHKDHGYFQNMLEEELTHVKDTELYREI --------------------------------LHKDHGYFQDMLEEELTHVKDTELYREI ------------------------------------------------------------ --------------------------------LHKKHGYFQHMLEERLEELQKDNSFQPL --------------------------------LHEDHGYFQHMLEEDLKNLKQTDEYREI ------------------------------------------------QRLRETQDYQTD --------------------------------LHKDNGYFQHMLEQRLETTKDELNSGTE ------------------------------------------------------------ ------------------------------------------------LRFQESQNSQID ------------------------------------------------------------ -----------------------------------------------------CDVLDKI ------------------------------------------------------------ ---------------------------------------------KQLEIVKESEGSEIE ------------------------------------------------------------ --------------------------------LHKDYGYFQDYLENELDSNFKEDSQTLM ------------------------------------------------------------ -------------------------------------FPV---NIILSDMYEPFPQLSPS FSQTDISQNIER-------------------------YPV---DVVLSDM---------- FTSDDNYDVSSTNSTLKEREN----------------FPI---DVIISDMYEPWPQ-TAG FSSISPNSSSEDEYKKMEK------------------FPI---DLIISDMYAPWPQSLIH FTSDDIYETPNTNSTLIEREK----------------FPV---DVIISDMYEPWPQ-TTG FTSDDNYDISNTNSTLKEREK----------------FPV---DVIISDMYEPWPQ-TTG FTSDDSYDTSRTNSTLKEREK----------------FPV---DIVISDMYEPWPQ-TTG FTSDDNYDTPGTNSTLKEREK----------------FPV---DVIISDMYEPWPQ-TTG ------------------------------------------------------------ YGMADPVHE----------------------------HPL---DVVLSDMYEPWPQ-VTG FGSDVELTNSSTSVEK---------------------FPI---DVIVSDMYEPWPQ-MTG TSSDEE-------------------------------KQL---DLIMSDM---------- QETKIQE------------------------------TPI---DVIISDMYEPWPQ-ISG ------------------------------------------------------------ TNSNEE-------------------------------KQL---DLIMSDM---------- -------------------------------------EQI---DLIMSDM---------- TFEEDEY------------------------------KHI---DLVMSDM---------- -------------------------------------QPL---DLVMSDM---------- IIDQKRKM-----------------------------LTV---DLVLSDM---------- -------------------------------------NEV---DLVMSDM---------- TDNDKPVNFSISK------------------------YPI---DIVVSDMYVPWQVFNTH -------------------------------------VPK---D---------------- LNNLTNMPYYR----MSNTSGLNFK-DHLNSIDLCDAALITAVD--LL------------ ---------------MANTTGIQSK-DHYMSMDLCDAALIVAID--LL------------ FWNNITNQAYFR---MANTSGVSIR-DHYQSIDLCDAALVTAID--LL------------ NTNKFTNDAYYR---MANTSGLTVR-DHQHSIDLCDAALVTALD--LL------------ FWNNITNQAYFR---MANTSGVSIR-DHYQSIDLCDAALVTAID--LL------------ FWNNITNQAYFR---MANTSGLSIR-DHYQSIDLCDAALVTAID--LL------------ FWNNITNQAYFR---MANTSGVSIR-DHYQSIDLCDAALITAID--LL------------ FWNNITNQAYFR---MANTTGVSIR-DHYQSIDLCDAALITAID--LL------------ ------------------------------------------------------------ FWNNFTNAAYSR---MANTSGVAVK-DHYMSMDLCDAALLCAIA--LL------------ FWNNLTNSAYYR---MANTTGVAIK-DHYMSMDLCDAALVVAID--LL------------ ---------------MVDCTGTGSA-DHIGNMELCTAALYLAYS--EL------------ FWNNLTNSAYDR---MANTSGVAIK-DHYASMDLCDAALVAAID--LL------------ ------------------------------------------------------------ ---------------MVDCTGSGQV-DHIGNMELCTAALYLAYL--EL------------ ---------------MVNCTGHEHY-DHLGNMELCGAATILSFD--TL------------ ---------------MVNTTGSSVN-DHYGSIYLCNAALHLAFH--QL------------ ---------------MANTSGIKDN-DHFASMDLCDGVLILACR--LL------------ ---------------MSNTSGIKDN-DHYASMDLCDGAIILACE--VL------------ ---------------MANTSGIKDN-DHLASMELCEGALMLAAS--TL------------ QNNITNIPNYR----MANTSGLAVK-DHAQSIDLCDAALVTAID--LV------------ ---------------KDSGGAIGTAPPSYLDTERELGSINSNSN--EP------------ -EPAGS-----FIC-----KQFS--GAETS-LFEK-RMKKVFDRVEITK-------PSAS -KPGGS-----FTC-----KLYA--GSEDT-LLEK-RLKKVFKKVDRFK-------PNAS -RPLGS-----FVC-----KLYT--GEEEN-LFKK-RMEAVFHNVHKFK-------PDAS -RPKGS-----FVC-----KLFT--GVEDK-LFEK-RVKMVFKKTIRFK-------PKSS -RPLGS-----FVC-----KLYT--GEEEN-LFKK-RMQAVFTNVHKFK-------PDAS -RPLGS-----FVC-----KLYT--GEEEN-LFKK-RMEAVFNDVHKFK-------PDAS -RPLGS-----FAC-----KLYT--GEEEN-LFKK-RMEAVFNDVYKFK-------PEAS -RPLGS-----FVC-----KLYT--GEEEN-LFKK-RMEAVFNNVHKFK-------PDAS ------------------------------------------------------------ -RPGGS-----FVC-----KLYT--GKEDQ-LLER-RLRKVFTKVRRFK-------PEAC -RPGGS-----FAC-----KVYT--GKEDK-LLEK-RMKMVFSKVCRFK-------PDSS -KPEKD-----MIL-----KVWS--GSELK-LFET-RMNIMFKKVIHIK-------PDAS -KPGGS-----FVC-----KLYT--GKEDR-ILEN-RLKQVFNEVQRFK-------PTAS ------------------------------------------------------------ -RSEKD-----MIL-----KVWL--GLELK-LFEA-RMNMMFKKVIHIK-------PDAS -KTGGN-----LVM-----KVWH--GSEEK-LLDL-RMRIMFERLVRMK-------PESS -KPGKD-----FVV-----KIFN--GSELD-SFQA-RLKLMFAQVHAVK-------PRAS -KKNGN-----LVM-----KFYT--GKEER-LLQN-KLEKVFHKVFMTK-------PAAC -KEGGS-----LVM-----KFYT--GKEDQ-VLQE-RMRLLFEKVYRFK-------PQAC -KTNGA-----LVM-----KFYT--GREER-QLEE-KCRKMFKKVHRMK-------PSAC -KPKGS-----FVC-----KLYS--GKEEN-LFEK-RLKKVFHKAYRFK-------PKSS -QFGDDYPVDIVLS-----DMCETLPQEHG-FFQR-TINDPYYRMANVS-------GIAV RDES----KE-----------IYFIGKKKKKNVDKLNV-----------FC--------- RNES----KE-----------LYFVARGKKTDIDKLKV-----------FLEE------- RNES----KE-----------TYYIGLKKKKNIDKLEV-----------FSS-------- RNES----KE-----------VYIIGMDKKEDIDKVEV-----------FTT-------- RDES----KE-----------TYYIGLKKKRNVDKLDV-----------FSNS------- RNES----RE-----------TYYIGLRKRRNIDKLKV-----------FGN-------- RNES----KE-----------TYYIGLRKKRNIDKLDV-----------FSN-------- RSES----KE-----------TYYIGLKKKKNIDKLDV-----------FSN-------- ------------------------------------------------------------ RSES----KE-----------LYFVGLDKRKDIDKVAV-----------FTQ-------- RNES----KE-----------LYFVGLGKRDKIDKLKV-----------FTH-------- KDRS----SE-----------LYMVGRRKVDLESKGIT-----------FNDILNATNS- RDES----KE-----------LYFVGLKKKRNIDKLKV-----------FMDDR------ ------------------------------------------------------------ KDRL----SE-----------LYMVGRRKIDLESKGIT-----------FDDVLNATNP- RSES----SE-----------LFYVGLRKRDLQKLGIN-----------LPDLFNTQEE- KDVS----SE-----------LYLVGRKKYDMKEKGIT-----------IEQLFG----- RAES----RE-----------MYFVALKKRTDVVSVED-----------VFSQEHDN--- RNEL----RE-----------MYIIGVGKKRDICVEEV-----------FH--------- RPES----RE-----------MYFVCLGRSN----------------------------- RSES----KE-----------FYFIGLNKRETVDKLDV-----------FTT-------- RDHA-----------------ASIVSEGRKRIGCGAAS-----------FDVAEGKP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ FMHL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MIVGYRGVVGVSRLANVYTRLFSSGVEAQKQDT ----------------------------MFQLRGIRTVGLLGKR-GRFFSTSRVV----- ---------------------------NLLKPTYFIAKSLLISINQRLFTTSREPEKKDK ---------------------------RAPLSRTLYLYLNTLRQTSRLFSSSMDSPIDKV ---------------------------SVLRSTCLFPRSLLISFNRRLFSTSRETKKKDK ---------------------------NVPRTACFIARSLLRLFNQRLFSTSREAKKKDK ---------------------------NVLRSTYLFARSLLISCSKQLFSTSRETKKKDK ---------------------------SVLRSTCFLAKLLLISFNQRLFSTSRETKKKDK ------------------------------------------------------------ ---------------------------VIMG-----FSSGIGMQARRLLSSSA--RGSGT ------------------------------------------------------------ ---------------------------SVIGISKQSPKSFISSQIIRSNSSSSDNNVKRK ---------------------------YQVKVGLLKARSKPLHF-SRFLSSSRVTEQKKS ---------------------------TLPGNARLFVLGFHSSFINRAYSTKV--EKKKK ---------------------------SIVGISKQSSKSFISSQIIRSKSSSSNDYVKKK ---------------------------CLVEAAFRLTRPLVLQQQRLYSSSTSTPKKKKK ---------------------------GIVGVGSQIKTSQFIRFNSISETENKDTIQKKK ---------------------------MILARSILAARTPIAAASARIISRGYADPKKKK ---------------------------PLLRYPGFVAFSGLSNVGSRFYSTE-PEKKKKK ---------------------------DLIDTNMIGRRTLVGSRPVPGISTSIDKAKKKS ----------------------------MLQTRFVKTQPALTSLSRCLLSTSREKEKKSK ---------------------------HNMASRRLVVRPFNMAGHRATYAPVRKSRLE-- KKIQDFNPRHLGVASELYVPASLSRLPSVLWFDNVIRRIYMLGLNTVQIGIFRFQTGIKP KKPAPFNPRHMGVANQVYIAPSKKNMPNPAYFNVLVRKIYTLGMNTIQVALFRYQSGLKP SKQQDFNPRHLGVASEIFIPSAYKNLPSVVVANALVRRLYTFGLNSVQVALFRFQSGIKP EKPDPINPRVIGIAMDMFIPSSFRNYPNVICLNALIRRVYNFGLNTINVGLFRYQSGMKP SKQQDFNPRHLGVAAEIFIPSAYKNLPNVIVANALIRRLYTFGLNSVQVALFRFQSGIKP NKQQDFNPRHLGVSAEIFIPSAYKNLPSVVVANALVRRLYTFGLNSVQVALFRFQSGIKP NKQQDFNPRHLGVTAEIFIPSAYKNLPNVIVANALIRRLYTFGLNSVQIALFRFQSGIKP NKQQDFNPRHLGVAADIFIPTAYKNLPNVIVANALIRRLYTFGLNSVQVALFRFQSGIKP ------------------------------------------------------------ KQQSGFN-RYLGVTDKIYVPTMYRNLPSVVVANSLIRRIYMLGLNTVHVALFRVQSGYKP ------------------------------------------------------------ KAGMDISPPYIGVMSDFYVPPKLTTCPITSWPKLITRRIMLFALNTYNIVKFKREIGVPL SKPADFNPRHLGISTNVYVPPSLKNLPSVVFSNAIIRRIYTFGLNTVQVALFRYQSGFKP TQQADISPKSIGIIADFYVPPKYLKSPVTSWHKLLFRRMGLFAINTYSIVKFKRETGLKL KAGMDISPPYIGVMSDFYVPPKLTTCPITSWPKLITRRIMLFALNTYNIVKFKREIGVPL NKNMSISPSVIGVMSDHYIPPKLTSVSITRWPRVLLNRFLLFGFNTYNILKFKREINKPL KKQPDISPNYLGCMADFYIPPKFTKSPILSWPRLIIRRISLFALNTYSIIAYKRELGVPL QKAPDISPKAVGVLADFYVPPKFRNCPITSWPKLLLRRIGAFGLNTFSVSKFKSDTKLKL SQAADISPKNIGVMADFYVPPAFMSCPITSWHKLLFRRLGMFVVNTYNVIKFKRETGLKL APAADISPRSIGVIADFYVPPRYLSSPVTSWHKLLFRRLGLFAINTYSIVKYRRETGLKL NEQLDINVRHIGVASDIYIPPTWRRMPNMSFFNVLIRKIYTLGFNTVQIAVFRNQSGIKP --------KHIGIMNEPIIP--LSHAPWTGLVKHFYRRMYAFVVNTFNVAQYRLKTKKKP AFLLWKNKAIETYVQVNANFASKSVEKLKPEWVEEALNARSKQIPDNVKLDWQLLKFNDV NFLLWKNKAIETYVQVNEAFAKRELDTIKPQWVDEALTARAKQIPSNITLDWELIKFNEV SFLLWKNKAIETYVNVNTSFARKNLSEIKGSWVQEALEARSRQLPSNATLDWQLIKFNAV NFLLWKNKAIELYIKVNTAFAEKKVNSVKDCWVDEALQARVKSLPKNILLEWELLKFNEV SFLLWKNKAIETYINVNTSFAHKNLSDIKGLWVQEALEARSRQLPGNATLDWQLIKFNAV SFLLWKNKAIETYINVNTSFAHKNLQEVKGMWVQEALEARSRQLPANATLEWQLIKFNAV SFLLWKNKAIETYINVNTSFAHKNLLDIKGMWVQEALEARSRQLPGNATLDWQLLKFNAV SFLLWKNKAIETYINVNTSFAHKNLSDIKGLWVQEALEARSRQLPGNATLDWQLIKFNAV ------------------------------------------------------------ KFLLWKNKAIETYVEVNRAFARRDLEAAQPLWVQEALEARVRQLPKRVEMEWDLVKFNGV ------------------------------------------------------------ EFNAWKDKGIENYVRANKVFARRKLDHSCGKHLIESLSARSLSFPEDSKLNWELKSIQNN NFLLWKNKAIETYVQVNRAFAARKIESVRPQWVEEALSARSKQLPKGAELDWQLVKFYKV HFNQWKDTAVEQLVKTNKIFAKSQLEGVTGAEVTKSLIRRASTFPPNSKLDWELLKIESN EFNAWKDKGIENYVRANKVFARRKLDHSCGKHLIESLSARSLSFPEDSKLNWELKSIQNN QFNDWKDQAIETYVRTNKVFATSKLDQSCGKHLNEVLTNRAVTFRQNIELSWDLVSIDKN QFNLWKDKGIESYIRANKSFANKNLDHVCGIHFIGALLNRSLTFPKDCKLTWELIKIEKD RFNDWKELAVDKYVKTNKIFAQSQLDGIAGIEVVKSLSTRALTFPARSKLEWNLKKIEGN QFNDWKDTAIEQYVKTNKIFAESQLADVSGAEVIRNLAERADTFPVDSKLSWELVSIGNN HFNEWKDTAIDQFVRVNKVFASTQLHDVAGAEVIKSLTARAATFPAGTRLEWQLTDIVGN KFLLWKNNAIETYVNINKAFAERKIEKVSSQWAEDALKKRQNKIPKNIKLDWKLLKFNEV RFTEWKNDAILNYIAVNKAFAARELESVDDKWVKKALVERSKTLPDDVKFQYGPIEFSKV PKLISIQPMMIPGRPLEHIQLLYRFNTKQRLVKLNKTNVEKLDRDVVDYMVFLCDATTND PKLVSTQAMMIPGRPVELIQLIYKFDTKQRLIKFDKKKTDKLDRDVIDYIAFLCDASTND PKLVSIQPIMVPGMPLEHLQLIYKLDTRQRLIKVNQQTSETLDRDVVDYVAFLCDATTND PKIVSVQPMMIPGRPLEHIQLVYRFNTRQRLIKIDKCTTDTVERDVIDYISFFCDATTNE PKLVSVQPIMIPGMPLEHLQLVYKFDTKQRLIKVNQQTTETLDRDVVDYIAFLCDATTND PKLVSVQPVMIPGMPLEHLQLVYKFDTKQKLIKVNQQNSDVLDRDVVDYVAYLCDAATND PKLVSVQPIMIPGMPLEHLQLVYKFDTKQRLIKVNQQTSEILDRDVVDYIAFLCDATTND PKLVSVQPIMIPGMPLEHLQLVYKFDTKQRLIKVNQQTSEILDRDVVDYIAFLCDATTND ------------------------------------------------------------ PKLVAVQPIMLPGQPLEMLQLVYRFDTRQRLIKVERGSAEKLDRNVVDHVAFLCDASTDE ------------------------------------------------------------ PKVVLFNIIPDADGIACFVQFILKLKTNQKISIVKDQKVKEQESSVEDYLVYSMNPISKE PKLVSVQAMMIPGRPLEHIQLIYKFDTKQRLIRLDKHTTTKLDRDVIDYVAFLCDASTDE PKIISFNALPDADNITALVQFVIQVKTKQKFTITTINSPQVTESSVENYLAYTLNPFTNE PKVVLFNIIPDADGIACFIQFILKLKTSQKISIVKNQEVKEQENSVEDYLVYSMNPISKE PKVSVFTTIPDEDGIGVYVQFVMNLKTTQKLTISDKRDIQQTETKVNDYLVYTMNPWDGR PKIISFNTIPDNNGVAVYVQFIMKLNSKQKITIKDKNDTQEKESSVEDYLVFSLDPVNQE PKLVSFTPIPDSNDISAVIQFVVKVQTRQEMVITGDAQ-SKTERSVTDYIVLTLNPYTDE PKVVSFNVIPDSNNVTVYVQFIIKLITKQKVVVTVQGQDQTTERSVSDYLVYSMDPVTRE PKIVSFNALPDSNNLTALVQFVCKVTTKQKLTITTQGKSNSNERLVTDNLVYTLDPFSGE PKLVSLQPLILPGQPLEHIQLVYRFNTKQRLLKLDKDSVEKVDRDVTDFVVFLCDASTNE PKVVNFTYLPLPNHAPGITLIIYRFDMTQKILRSQRRSVKTTTKKSTEYIGCVYDNTPAK LILMGSVFESKPDAKLPKNYDDNTEKAVRRMKECGDIYRVPSSPPLLNPLLNAICNCGEP ILLTGSVFESAPDAKLPKDSETSNQIVIERMKVNGDLFRVQPPPVLLNPLLNAIFNCPSP MILMGSVFENKPNDKLPKSYEDDTKVAIHRMKVNGDIYRLPSNPTLLNPLINAIFNCPEP MYIMGSLFESKPEGKLKKTYSDDNKEAIRKMRICGDLYRVEPVPTLLNPLLNSIFNCPNP MILMGSLFESKPNDKLPKSYEDDAKVAIHRMKVNGDIYRLPPSPTLLNPLVNAIFNCPEP MILMGSLFENKPNDKLPKSYEDDTKVAIRRMKLNGDIYRLPPEPTLLNPLINAIFNCPEP MVLMGSLFESKPNDKLPKNYEDDTKTAIRRMKMNGDIYRLPPNPTLLNPLINAIFNCPEP VILMGSLFESKPNDKLPKSYEDDAKVAIHRMKVNGDIYRLPPSPTLLNPLINAIFNCPEP ------------------------------------------------------------ MLLVGTVFEAAPDAKLPTT-EASSEETIQQMRICGDIYRSPPAPVLLNPLVNAVFNCPAP -------------------------------------------PILLNPLVNSVFNCPTP LLLVGKLFESDHIRGLPEMDVFDQKLMQRFLKTSSDIYRTDPKPICIIHSLIVFLTIHNT IILIGSVFESEATAKLPKNYEDDMQTAIQRMKTSGDLYRVNTKPVLLNPLINAVFNCPTP MALVGSLFESDHLRGVPEINFTNSQVMASFQVSCADIFRAAPKPLLYNPFLNCIFNNPHH LLLVGKLFESDHLRGLPEMDVFDQKLMQRFLKTSSDIYRTDPKPILHNPFLNCIFNNPQY ILLVGKLFESDAYRGLSELDVFDTKTMGDFLNEAADIYREDPRPILYNHLLNCIFNNPHY LLLVGKLFESDHIRGLSDLDMLNTKEMQRFLKLAADIYRADPKPILYNPFLNCLFNNPQY LVLVGTLFESDHVRGVPELEMENVRALENFQKMCADIYRAPPEPLVYNPLLNCIFNNPHH LFLVGKLFESDHIRKVPDDKFTNPKFMIAFTRASGDIYRANPKPLLYNPFLNCIFNNPYY MVLVGSVFDSDHIRGVPEINFTDAQTMTKFQVLCSDLFRSNPNPLLYNPLLNCIFNNPNH VLLIGSVFESKPDAKLPKNYDSDNKSAVARMRECGDIYRSQIPPVLLNPLINAVFNCPDP CLLAGTVFESPIDIPLPDPDMSDERVVIQSMHDKGDIFREPKA----------------- NSSLGKDKYLILVPPTELLLYYSDKESNSELHDLCYTPNFASAHILLLTDTEVNNGDHFK KTSLDDERFFILVPSTETLLQFQDLESGLELAELCYHYDFVASHIVVIKDPTKDVPDDFT EKSLQTRRFILLAPPSHLLLNYHDVKTKLPLHELCYNADFINSHILLTTENSYINTTHYE SNSLKDKSFILLVPPTETLLNYTDTKTKIQLEDLCYNVDFIGAHILLPPKDSISSSSQFD ERSLKTRRFILLAPPSEYLLNYHDVKSKLPLHDLCYNAEFINSYILLMTENSYINTNHYE EKSLKTRRFILLAPPLRFLLNYHDVKTKLPLHELCYNVDFINSHILLTTENSYLNTTHYE EKSLKTCRFILLAPPSEYLLNYHDVKTKLPLHELCYNAEFINSHILLMTENSFINTNHYE ERSLKTRKFILLAPPSEYLLNYHDVKTKSPLHDLCYNAEFINSYILLMTENSYINTNHYE ------------------------------------------------------------ GASAKDKKFILVVPRTEVLLQYQDATTYVPLTELCYNYEFVASHTLVQLQEARVTELEFQ STSLRDQRFILVVPNVNILLHYQDLDTGSSLQDLCYTYEFVANHIIILKKDSKYSDQEFK SNRLQSTNFTILVPPAHVLNEYYDPTTKTLLKELCYNEDFIRSHIINTPVSSTITPIIYN LNSIEKVRFVLIAPPTELLLEYEDLESGLPLQDLCYATGFVSDHIVLLREGLQEE--EYK SKNLSENDYTILVPPAHILHELFDPSTKIRLHDLCYNEDFIRSHIIKTTYPSITSSKIYV FKSLQSTNFTILVPPAHVLNEYYDPTTKTPLKELCYNEDFIRSHIINTPVSCTITPIIYN NKSLRTNQYTIIVPSAFVLNEFYDPATRVLLKELCYNEEFIKSHIIQTPVSSTITPIIYK FKSLKSTHYTILVPPANVLHEYYDPTTKTLLRELCYNEDFIKSHIISTAVSSTITPIIYN SKSLCRNDYAILVPPAYILQECYDHSS-QKLSEICFSEDFVKSHIIKTPLSTSSAPVLYS NKALARNDFTILVPPAHVLHHCYDPATKVLLRELCYNEEFIRSHIIRTSYSSTITPIIYN SRALASTDFTIIVPPSSLLHNSYDPESKIALHDLAYNEEFIRSHIVKTNSHAFLAPVIYN INSIKYKNFMLIVPPNEILLHYRDPEKGLTLKELCYEFEFVASHIILDTDNSSNNLQRYK ------------------------------------------------------------ AMDQSWKFIKNRVIYEFNGDQIKNRAKILDIESIPIFNNYMKITIMYIDDVFLNGTLENL TLNGRKLSIRNSTIVTGDGFTERRKITIKEINLLPTFNDYLKTPILHISMPLCGDLVPLD TLDGKTVVVKNNVIHTLNGFPLRRRLKILDTKILPNFNDYFKFAILYIDQPLGCEFVPND TLNGDNILVRNNFLVLLSGSPNRQKIKIERIQVLPNFNDYLQFILVHIDKPLMKDVIRND TLDGKTVVIKNNVIHALNGFHIRRRLKILETKILPNFNDYFEFIILFIDQPLNCEFVPND TLDGKAVVIKNNIIHALNGFPIRQRLKILETKVLPNFNDYFEFAILFIDQPLNCEVAPND TLDGKTVVIKNNVIHALNGFQVRRRLKILGTKILPNFNDYFEFVIIYIEQPLSCESVPND TLDGKTVVIKNNVIHALNGFHIKRRLKILDIKILPNFNDYFEFIILFIDQPLNCEFVPND ------------------------------------------------------------ TINGKSVVIQSGII---TAQPSAKKCRIQRCELLRSFNDYLLFALLYIDRPLVGEIEL-- TLNGKTVLIQNGIVLTGDGFPSKRRCKITNTELFINFNDYLKFPLIHIDKPLMSDAVKND TLNNKQILIKNRIIYTGKGFRRSLKLKTLSIQYFSSFCDYFPFMIIYIESTLFGGIPPRK TLSGKTILLQQGIIFTAAAFDTRRRCRIQRAELLTNFNEYLKFPIIHVDFPLTGRLARRD TMNGKQILIKNGIVFTGKGFKKSLRLKVLDINYFNSFCDYFPFMILYIEDSMFGSFDP-N TLNNKQVLIKNRIIYTGKGFRRSLKLKTLSIQYFSSFCDYFPFMIIYIESTLFGGIPPRK TMDNKQVLLKNRMIYTGKGFRRSLKLKILAVSYFRSFCDYFPFMLVHIESTLFGGQPYKS TLNNKQVLIKNRMIYTGKGFRRSLKLKIASISYFSSFCDYFPFMVIYIENTLFGGIPPRK TMNGKQVLIKNGMVFTGRGSKRSMKLRILNVNYFISFCDYFPFLLIYIEDSLFGHKPMVE TMSGKQVLFKNGMVFMGKGFKRSLKLNVLLFQYFSSFCDYFPFMILYVEDCLIGSFDPHQ TICGKQILVKNGMIFTGKGFRRSLRAKITDIGYFDSFCDYFPFMLIYIDNSLYGSSDHEP SLNNNQLLINNIIPLDFNNSTQKKKYKIIDIKILPNFNEYLSYTIIYTDYPFSNSWLPKI ------------------------------------------------------------ RSDIDLLRSPSMRSIPSKSKTFDSILRVNKHWSSKFEQHFQKFRLLANQDDLPIDVFHNI ELQVFSKVAGNKYSKQKKVLYFEQRIQSISDVAERVALTF-HLTKARIKKAISRTEWLNT YLHCFNSYEETSKTARLERSSFENILHIHPAWLTQLGQLFSNYRRAALNDDPSKKMFEEL ELECFDTLTLHDNDGDHERSQFENIINTNDTWNKRFKDWMNEYKDSTTAEEPNETLFKQI YLQCFHNYEKIPKNAHQERSSFENILHIHPARLTQLGQLFSSYRTLAPGDDPSRSIFESI YLKCFDSYEEVPKNAQQERSSFDNILHIHSARLAQLGQLFSNYRRLAPNDDPSKKMFEDI YLQCFHSYKKIPKSVYQERSSFENILHIHPTRLTQLGEMFSNYRTLAPSDDPSEKIFECI YLQCFHSYEKIPKNAHQERSSFENILHIHPTQLTQLGQMFSNYRTLAPSDDPSKEIFESM ------------------------------------------------------------ -ITPLRVFGPQEQPLQAPLP-LEQFLRLHPQLGNQLDEVFKDAKERMRYIALSVRLFHEL ELQVFGVRSTNTSSLPREVSSFEQLFRLHPQLGDRFSGLFKEQRQEINANFKGVDFFDKF MLPPLPEVRETNKTDK-DSVTFEKLLRSFPLLSKAVSDKFYQFRVLRYKNRKKKLEFQKI EWQCFRVTKNQEHTNGGDNNSLEQLLRINPEYGESLNDIVKAQRISLNSSVTGASHFVQT VPVSMQSREMDEIKIEHDIT-FEKLLRSFPLLSNAVSDKFYQFRLLRTNTRKKKFEFQSM MLPPLPQVRESNETKK-DSVTFEKLLRSFPLLSKAVSDKFYQFRVLRYKNRKKKLEFQKI SLPLAPILNVNDSSTANESVTFEKLLRNFPLLARAVGDKFHQFYGLRSNTRKKKIEFHKI QLPPLPITQESNITKTLDTITFEKLLRSFPLLSKAVSDKFYQFRGLRYNHRKKKLEFSKI GPPATPVDEP------ESAITFEELLRNFPVLSRAMSDKFRRFQRLRTRQRMSRNEFTAL HLSRIPQDDETSSQRSQDSITFEKLLRSFPLLSKAVSERFHQFRVLRINTRKKRIEFHSM ALEASPKAQQAKIK--TESITFERLLRNFPLLSKSVSDPFYQFRVLRTNTHKKKSEFDNM EIESFYISKKESNNIKKTKSSFRHIINIHKEWNNIFDSYIIDFK----NKQLNPIYFREI ------------------------------------------------------------ IEEMHEEMVSDNLFKNIDLRNIIYEYVELNLFDDIWKMILRMNEVEIDLNP----FGNIS RDSIRQIISLDKRLNHLDLDAMIYDYVELKLFTDIQQQLSEIVDQELEHRFDFKALRSIS VEQAFDGMKSDSLFKNFNLYDLIHDYFELNLYEDIWSRLTIHFYEVNTENCEYFSVNQLL VAVAYNELKSNKIFKGFHLRRLIHEYLEINLYDHLWLQITTLCDETKGTRIKNISIEEID VQQAFDGMKSDSLFKNFNLYDLIHDYFELNLYDDIWSRLTTHF----------------- VQQSFDGMKSDSLFKNFNLYDLIHDYFELNLYDDIWSRLVTHFYEVDTEKYKYFSVNQLL VQQAFEGMKSDSLFKKFNLYDLIHEYFELNLYDDIWSRLTSHFYEVGTEEYKYFSINHLL VQQAFDGMKSDSLFKKFNLYDLIHDYCELNLYDDIWSRLTTHFHEVDSEKYKYFSVNQLL ------------------------------------------------------------ VEKVYCLIKLDKNFRNYNLLEMVQGYVELNMYEDVWRKLVQL-KNEPDRVPGYYITRSIS NYEAFELIRHERRFENHKLHQTVHNYVELNLYDDIWKQITQLYDDEIEATYDYNLLKYIA LQEAFSIISDSSMYPRIDLNKLVHEYVELNLYDVLWSQLIFQFPNDDKEAYDPEAILILT CKKALDVVRAYPAFQVLNLPICVHEYIELNLYDDYWAQLTNSLDSEIESSSDYSLLKHIS LDEAFKVVLDSRLYPGLDLNRLVHEYVELNLYDKLWAQLIFQFPDNDKQNDDLDAIKILT LQEAFSIILDSSMYPGIDLNKLVHEYVELNLYDVLWSQLIFQFPNDDKETYDPEAFLILT LDEAFKIILDSSIHPNLNLDKLVHEYVELNLYDVLWSQLIYQYPNDDKADYDPSATKVMT LEEAFKIISDSGMYPGIDLNKLVHEYVELNLYDVLWAQLIFQFPNDDKEEYDPEAMKILT VDEAFSIIQNCTQHKNVDLNSLVHEYVELNIYNKVWSQLLFQYEVDDGLYEDDKPELILT LDEAYKIIQDSSIYPGLDLNRLVHDYVELNLYDKLWAQLLFQYPNDDKQSYDPEAVKFLT LEEAYQIISNSRSYPELDLNKLVHEYVEINLYDKLWAQLIFQF-SANAGLADPDATKIFT VDKAYQKMKFEEIFLSFDLYNLIFEYLESSFYNSIWDHIDRNMQFLHTEMMDFLSIDQLE ------------------------------------------------------------ IYQVDSYSKFFLENVITAERNIKEASKSLQKIESASNYKSKANILILTLRTLTGNKEPLA LNQVPTEKSFSLASVVELEKSVNDALEYLKSIDLKTTHSGKLEVLSTTMRLLS----GIS TDYYSKFESFKLSDITFIERRVSVASKHFQKLALSHSYAEKSKILVETLQHLSGTTDNLT D----KYEMFPLDFITKLEKNMVRSTNSINKLNGKNSFNEKSENLIATLQILTNMDNNNL ------------------------------------------------------------ ADFFSKFKEFKLSDITFIERRVNVASKHFQKLTLTHSYAEKSKILVETLQQLSGPTESLT ADFYSKFREFKLQDVTFIEKRVHLASKHFQKLTLTHSYTEKSKILVETLQELSGTTDNLA ADFYSKYREFRLNDIILIEKRVHLASKHFQKLALTHSYAEKSRILVETLQKLSGTTENLT ------------------------------------------------------------ LNQLSTLDKFNLSPVTEIEKRVVQATECFSKLTLTNSHHEKARILISTFQKLTTKTSDPM ISQVPTQSKFSLKKVTHFEKSLEQATDCFKRLAFSSSHSEKTKIIMDTLQTLTDYSEDVT KEKYEKIPVNKPWLMNELHERISLGVQEFEKLADSSISAAKTQVVYSTFRILTQRKNDPV VSQVPSPEKFDLRLITQAEKNVKGAVESFRKIAVTNCHSAKAKVIIETLQTLSRSLLAVT KEKYDHVPTDKPWHINELHKRIYKAIDEFSKLSDASILSGKTQILKNTVNILTNNVKGIT KEKYEKIPVNEPWLMNELHERISLGVQEFEKLTDSSILAAKTQVVYNTFRILTQRKSDPV SAKYEQVPLNKPWQLNELHHRIYQAVQELKKLSTSSTLAAKMQIIYNTINILTNPSQDLV SEMYEKLPVDKPWQMNELHERVSLAVQEFEKLADSSISNGKTGVINNTLQILAQGKHSLV PNLYRDIPVDEPWNLNVLYRRVSDAIEQFSQLANSTVANQKQKVLLNAVNILTTGSPDLV AETYNRIPIFKPWQINTLQEKVALAIEEFSKLADSSILTAKTKIIINTVNILSDLKSDFV AEKYDEIPVDEPWLLNDLLLRVYNAIIELSKLADATISSSKLKIISNTISILTENSNSLM LELYNQFQKFNLVNVIKVERCVKDATDQFKKIIDSKSHSEKCQILIDALQKLTSYDDPLM ------------------------------------------------------------ IDADRLMNLFVLVTCRAQIKNLKCHLSYLQNFYNNDSDKFGILGYALSTLEAVVCYFLKY TDADTLLSLFVLLICRSQVTGLVRTLTYLTNFEISETSKFGLQGYVLSTFEAALSFFHQV MDADTLISLFVLVVCRSEQKHIRSHLYYLQNFSNNSSSKFGILGYAISTLEAVVCYFNKV IDADTLINLLILIICRSEINDLKRNIFYLKKFNYDENLNFGILSYTISTFEIVIYSFVEY ------------------------------------------------------------ MDADTLLSLFVLVVCRSEQKHLKSHLYYLQNFSNNPSSKFGILGYAISTLEAVVCYFDKL MDADTLISLFVLVICRSEQKHLKSHLYYLQNFSNNSSSKFGILGYAVSTLEAVVCYFKKM MDADTLISLFVLVVCRSDQRHLKSHLYYLQNFSNNSSSKFGILGYAVSTLEAVVCYFSKM ------------------------------------------------------------ IDADTLLGLMVVVVCRAQVKNLKSHLDYLREFAQNSDDKFGLLGYSLSTLEAVVGYFDIL IDADTLIGLMVLVVCRSQVKNLKSHLFYLQNFSLDENTKFGVVAYALSTLEAVLCYFAEI INADTLIGLLIMVMIHSKIENIEAHIYYIKHFNSIDNTNDGQFNYIMSNLDAVLFHFSKY IDADTLVSLFVVVVCHAQVKDLRSHLFYLQEFTKDTNLTFGILAYGMSTLEAVLCYFEKV VNADILIGLLIMVIVHARVDNLEAHLYYIKHFNSVDYTNDGYFCYILSNFDAVIYHLMNY INADTLIGLLIMVIIHSKIDNIEAHIYYIKHFNSIDNTNDGQFNYIMSNLDAVLFHFSKY IDADTLMALLIMTIVHAKVDNFEAHLFYIESFSASDVVCDGHFSYIMSTLDAVICHLSDL ISADTLIGLLIMVVVHSKIDNLEAHIYYIKHFNSTDHSNDGQFNYTMSNLEAVLFHFSQY VDADTLIGLLIMVVVHSKVPNLEAHLYYIRHFNTASAEESGYLNYILSNIDAVIYHLNKL MDADVLIGLLIMVIVHSKIDNLEAHLYYIKNFSAIDYSGDGHFNYIMSNLDAVLFHLSSL IDADTLIGLLIMVVVHSKIDFIEAHLYYIKNFMYGTISDDGYLSFIISSFDAVFFHLHPY VDADTLMNLFLLVICRSKVPFLRNHLYYLQNFSTDENNKFGLLGYGISTFEATLCYLKDF ------------------------------------------------------------ RDFCNSNERLVKVLSSTKKYETNKYEGSLRYRDSLGQSLLALCIIHGRNDFLYHILNYET DKKCASNKKIWASIQKHSKVEAELLSSNLRIRTDSGESLLSICIQSHNNEVLTTLLAFES ALLCIKTRDLLDKLSCENPTNEVTYKDILAYRNEQGQSILSLCITNNKNDILLDVLSYEA DSYSEIIEKLIKVDDLKKVPKTIKWEQFLTFRSDTGESILFSCITNNQTEKFLDLLVYEE ------------------------------------------------------------ AVSYQKTRELLDKLSSENPTNEITYEDNLQYRNEQGQSILSICITNTKNCILLDVLTYED AVLLQKTKRLVNMLSCENVTNKVTYKDILPYRNGQGQSILSICISNNKNHILLDILSYDS AVLCEKTKNLLDKLSCENSTNELTYKDILLYRNEQGQSILSICITNNKNCILLDILSYEN ------------------------------------------------------------ ETQCQRNKIFWNLIEQGIPINLKEHEEVLISRTPSCESVLSLCIQYGRQDVFYDIIAYQS RFNCRRNKQFWDHLSCKAVS---SYRDILRIRTAGGESCLSVCIQKGNFSGIECLLQFEH LENSKKNYEIWNAIKNNDLEKVEPENHFLKSKNINGESCLMFAIKTKRYEIYDCLINNPN AKYCRANLSHWKSISEGSIDLNAPLDDLLKIRTSDGQSCLAVCLQHRRTEEFELIKNREA AKSSALNHKFWSLIDSGDTDNLLPNNHFLNSRTVQGESCLMMAVKADNLDAFNYIINNYQ LENSKKNYETWNAIKNNDLEKVEPENHFIKSKNINGESCLMFAVKAKRYDIYDCLINDPN NQSSQQNLELWSAIFELDLVSITPEQHCLKSRNISGEGALTFALKANNYDVYKLLLDNPN VENSKKNYDLWNAIKNQDLESVQPENHFLKSKNINGESCLSFAIKAKNLEVYNLLINNAS KSFSAQNYELWYSISMQKMDTLQPTNHCIRSKNIHGESFFVFAIKAKSPGIFRMLLTTAA SVHSQQNFEFWSAIQQGDVDAAKPSSHYLKSKNINGESCIMFAIKAKNFSIYDMLINHPN AESSQKNFEFWSLIRSHKVDEITPHNHFLKARNINGESALMLAIRSKNYDTFLLLLSNPN NLNCIRNKELISKISSEADHSTFLYKDCFKFRNEMGESILALCIKHKKNETLFEILLFED ------------------------------------------------------------ LFPIEDLLADESIDGSTLLIQAVKHDNQYSASLLLNILKDNCTEIELIAYINRHDINKRT EFPLEDILDDRDFALSTLLIQALQVQNSQAAAILSEIILKSCTESEVRSYLNSPNLHNRI LFPIEDILEDETIDGSTLLIESIKVGNLEATKILIRIMLFNCTDEELVTYVNKTDKYARS IFSMDNILDDANVEGTTLLMQALIYRNFKISMVLINLLLRNCSNKQIMEYINKIDKFNRN ------------------------------------------------------------ LFPMEDILEDETLDGSTLLIESIKTGNIEAAKILIGIMLLNCSEGELVSYVNKADKYART IFPLEDLLEDETIDGSTLLIESIKSGNLEAAKILIRIMMLNCTEEELISYINRTDKYSRT IFPIEDLLDDEAIDGSTLLIESIKAGNLEAAKILIRIMMFNCTEEELISYINKTDKYART ------------------------------------------------------------ HFTLEDILQDVNQSNCSLLIQALQAGNKDITEAVIDLLIANCTNTEMYAYINKCDIAGRT ELPLEDILDDQTINGSTLLMQTLETGNTRMADVLLEILCQSCTINELREYLNRRNRWKRT WIPIDSILFEKNVTNQNLLMCALIEETDKIIDDLVDIILNNATLEEQTMYFNMTDISGRS WFPLEDLLHDETTDGSNLLIHMLESGCDRLAVMLINTLISNCTKDELIAFLNHTNKYQRS WFSIDDILFDKNTTNQSLLTVALTQESYNIITQLVEIILSNTTLEEQILYFNSVDNSGRS WIPIDSILFEKNVTNQNLLMCALIEETDKIIDDLVDIILENATLDEQIIYFNMTDISGRS WFTIDDILYEKNVTNQNLLMCALLEETKQIVLDLLETITENATVKEQQAYYNMQDLSGRS WISIDDILFEKNVSNQNLLMCALIEESNEIMDDLVDIILDNATPEEQYMYFNQTDLSGRS WISLEDILFDVNTTGQNLLMLALQEEVPEIVEDILDVLFANTSKRELELYLNSRDNNGRT WFSIDELLFDKNITNQNLVMVALADECPEIATDLVNVILSSATKEEQVAYFNSVDNAGRS WFSIEDILFDRNTTSQNLLMVSLMEETKIITKILIEIL-GSCTLEEQIAYINSTDYSGRS MFPLEDILDDEDIEGTTLLMKALKVENEVGAKLIVDVLQSSCSEDELIKYFNRTDNNQRI ------------------------------------------------------------ AGHFLTNELEVLKLMGKYINWVQKDNAGQTPLFTIFRSYDQDNYDEMVSQSMEYANWYGL TAHYIMQDISLLESVGRYFNWEHKDINGHTPLFAVFRSYDAVNYDEIVTKVLDQVKWYAN VAHYLTHEMDILKSIGSYINWKQKNSSGQTPLFSIFRSYDQPNYEEMVKVAFNIASWYQR VGHYLINELEILKIIGKYVNWKQRDLVGRTPLFTIFRGYDQPNYDEVISTVFDITNWYAE ------------------------------------------------------------ VAHYLTHEMDILKSIGSYVDWKRKNSSGQTPLFSIFRTYDQPNYEEMVKIAFNIASWYQK VAHYLTHEIDILKSIGNYVDWKRKNSGGQTPLFSIFRSYDQPNYEAMVKIAFNIATWYRK VAHYLTYEMDILKSIGNYVDWKRKNSSGQTPLFSIFRSYDQPNYEEMVKTAFDIATWYRK ------------------------------------------------------------ VGHYLPQNYEIVDRLGKFVDWKRKDLNMHTPLFTVCRAYDHPSYLELLSKCFQHCDFYST AAHYLTQDLQMADKIGIFFDWEAKDISGHTPLFAIFRSYDHPDYAQMVTNAFRTAKWYEI VGHYLFHNYKLISKIGHLIDWEKKDNNSHTPLFSLCRCYDHPEYVELIRAGFNCVKKYGE CGHYLMHAPQLIDLVGDILNWEQRDCNGHTPLFAIVRAYDRPDYFDMVSAAYRAAGQSKV AGHYFHHSPNLIDQIGFLIDWELKDLNSHTPLFSLCRCYDHPDYATLLEKGFDCIKKYGK VGHYLFHNYKLISKIGPLIDWEKKDNNSHTPLFSLCRCYDHPEYVELIEAGFDCVKKYGE IGHYLFHNMSLISKIGHLIDWELRDRNTHTPLFSLCRCYDHPEYIELVQAGFEAVLQLDK VGHYLFHNYKLIAKIGHLIDWELKDNNFHTPLFSLCRCYDHAEYIDIIAAGFDCVQKYGE VGHYLSHDLDAMDRVGHLIDWESKDVSGVTPLFSFCRCYDHSQYELLIKKAFECVNQSSG VGHYLFHNYKLMGILGDIIDWELKDLNSHTPLFSICRCYDHPNYPTLISEAFACVQKYGG VGHYLFHDYELINEVGHLVNWELKDHNSYTPLFNICRCYDHYAYYDLIKTAFSAV----- AAHYITNQIDVLKRIGLFFNWKIKDDKGYTPLTTICRTYDQECYEQMIETAFFEAKWYEN ------------------------------------------------------------ NGFNYLDHVDKKGNTLLHILKCNLPILLADKHINVNATNRSGQTPLMTSIRYKRTENIRD NNFNFKIHEDPKGNTLLHVMKSGIESLLKLPDVNVNKPDSKGLTPLMIYSRYNRITNIET HNFGYSDHTDNKGNSLLHVLKTDVSILLQLTKLNINGENYKGLTPLMVYVKYKRLSNIDA NGFQMSDHYDLKDNSILHILRSNIDILFTYSKIDINKRNYKGFTPLMIYVKYHRLSNVKL KG---------------------------------------------------------- HNFDYLDHTDSKGNSLLHILKSDVSILLQLSKLDINGRNYKGLTPLMIYVKYKRISNIDA QNFDYRDHTDNKGNDLLHVLKTDASILLQLTKLDINGENYKGLTPLMVYVKYKRLNNIEA HNFDYLDHTDNKGNSLLHVLKTNVSILLQLTKLDINGENYKGLTPLMVYVKYKRLSNIDA ------------------------------------------------------------ RGFSFADHEDPLGNTLLHIIKDGIQLALSTPGANVNKCNTRGMTPLMVYAKYNRIENIRE RGFNFSAHKDTKGNTLLHVMKTNIEILLEQENIDVNEVNKKGLTPLMVYVKYNRLDNVKC TGVDYDKHVDKSGNTLLHVLLKGIPESKMLSNVNVNQLNQRCLSPLMVYVKYNRLENLKE RNFRVSNHTDDKGNTLLHVIKSDVSILLADPFIDVNATNAKGLTPLMVYVRYNRIGNVRT --IDFDKHIDKMGNTLLHIILKDLSKTKLLTSINVNQLNYKNLTPLDLYVKYNRLENLKE TGVDYDKHVDKSGNTLLHVLLRGIPESKMLSNVNVNQLNQRCLSPLMVYVKYNRLENLKE SSIDFEKHIDKNGNTLLHVILKGIPETRILSRIDVNISNYRHLTPLMLYVKYGRLENLES DGIDFDRHVDKSGNTLLHVLSKGIPETRILSNINVNQLNSRCLSPLMLYVKYNRLENLKY --FTFENHIDKNGNTLLHVLSKGIPESQLLSRIDINQVNDKLFFPTAIYVRFSRLDNLIC ENINFDKHIDKSGNTLLHIILKNIPESQLLSRISVNQQSSKYMTPLTLYVKYYRLENLKD MSFNFKKHTDKYGNSILHILLKGIDQSGLLKAINVNCTNSKCLTPLTVYVKYGRIENLIS RNLNFKDHNDSKENTLLHILKCDIQVLLKYDNININAHNLKYITPLMTYVKYNRVSNIQE ------------------------------------------------------------ LLCDPRLRVDITQKNNLTAFDFSKDDEITHLLGEHELLNAVYAHTLKYPKTNFTLKTLRG IMKDERLLCDLVQQPLMTSLDFTKNPKVTKTILDATFRE-VVIHSLRFGIKKYSLDLIQY ITKDHRLILEKVQNSTFTCFDYAKDRLVLSKIGERGANDLIYLHSLRYFVAVINMKTIQG ILGDDRLLFNRYQRELTTCFDYATDSTISNELGKHALNNRIYIHSLKVTGVNIKVKAIIS ------------------------------------------------------------ ITKDSRLILEKVQNSTFTCFDYAKDHSVLSKIGERGARDLVYLHSLRYFLTVINMKTIQG IIKDQRLVLEKIQKSTFTCFDYAKDHTVLSKVGERGAKDLIYFHSLRYFSTVINMKTIQG ITKDRRLILEKVQKSTFTCFDYAKDHSVLSKIGERGVKDLIYFHSLRYFATVINMKTIQG ------------------------------------------------------------ ILNDKRLILSKLQDPQLKAIDYVKNPIILNLIGTAMAKNCLSVHNIKYYKSSYALKDIQS ILRDNRLIMEKHQKSLLNCFDYVKNPVIQAELGFHAAKTEVVAHTFRFFQVKHNIRAIQG ILHDSRLDFLGEDFKNYNVFDYLSFSALKSTKSENFQIEAVFNYYLQNFCNYKSLRNIKQ ILQDQRLIIGKHQSGALSCFDYVKNPAVLKELGKYASLPSINVHSVKRVKFKRSLRFIQA LLKDDRLDFKFEDSTNYSVFDFLGSLTAKSPTNTVLKIELIYNYCFINPTNAETLDRLRK VLKDSRLDFLGEDFKNYNVFDYLSFLALKSTKSEKFQIEVVFDYYLQNFCNYKSLRNIKQ ILADNRLDFLAEDPSTYNIFDYLSFLAGRYAKENVEKE-KLIEFYFSHKARPKSLNSLKH LLEDSRLDFLAEDFKNYNVFDYLSFSALKSIRTEKFQMEMIFEFCLQNFCNYKSIHGIRQ LLKDSRLFFDWEDSKNYNILDYCSFSASKAANETNQAKSVVVEEYFKHYSKYVTMDCLRQ LLQDNRLDFLLEDSKNYNVFDYFGFLSMKSTIPNETFKILIFGFYIDNGINHKSLEMLKQ LLQDKRLEFMFEDKKNFNIFDYVAFSSRKQGDNDRGNEEFIYSHYFKHNQIILGLDSIKQ IIRDERLILGKYQKHTLDCYDFVKNTIIFEDLGVRSVRNLFSAYSLRVYIKSVSLKILFN ------------------------------------------------------------ ILRVVIKNNMTVFLPVQELVEDLISFNRIRFSELMREMLPFISFCLSALVHIKVLDLNVF YLRYLKIMYPCSFHPVQLLTNELRLLGIYGVPGVLRHTFKKLDMLFSYVNTRGKL--WLG LLRSIVKDNPFTFLPIDNYIDGISHLNRSDLTIIGKSLLHKLTNCFNVLLFLKKVPQNLF LLKVIRKKSQISLLPLDRIIKVLVKLTSENNKIIVRSLLRRLTDCLDTLLFFDIGIDSLI ------------------------------------------------------------ LLRSILKDNQFTFLPLNSYIDEISHLNRSDLTIIGKSLLHKLTNCFNVLLFLKKVPQNLF LLRSILKDNPFTFLPLNIYIDEISQLSRSDVTIIGKSLLHKLSNCFNVLLFLKKVPKSLF LLRSILKDNPFTFLPLNTYIDEISHLNRSDLTIVGKSLLHQLTNCFNVLLFLKKIPENLF ------------------------------------------------------------ LLQIYNKKHPMSFLPIDHHLETLKTLGKSGIISVINMLLEALTFSLSIIQQREDYKNVFS LLQVYLRRNPMSFLPIDAVLEDLHEIGKTGLVSVGKRFLCELTLVLKLICQKEEFKKALY ILYLIKLKQPLSTFPSEESFWKNYGFGISTSPMFHKRLIDDFNLLFEGLTFQESINQFLT FLTLFSDAHPMTFVPVDELLRELRALSQSRILILNKRFLKRCSVTLSMVSQERLFADAFT FTYIFKLDHTHSFFPDNETFWLNFPQEKSMVPIFAKRIIEHVNMYMISLNFHPILTNNFF ILYLTKLRQPLSAFPSEEAFWKNYGFGISTSPMFHKRLIDDFNLLFEGLTFQESINRFLT ILYLEKLQRPFTTFIDSDIFWRNYATNISTTPMFHKSLIHRLNILFQSVACQNIGDSRFL ILYLTKLKHPLSSFPEEDSLWKNFSIGASTTPMFSKNLIESFNKLFQSLVYSQSIDRFLS FVQIQKFSNPLGFDISPDEFWVNFPPGKQVIPFCSKRVLEHLSTYFSSMNFVSDASKSRC IIYFIKLDNPCTYLPDKDVVWLNYGLG-STTPYFHKRLIDTLNLFFTGLLYRNGNCYTGR SHHSFKLKNPHSLIPDVEKVWLNYPANGSVAPIFAKRLLENLNIFLVCLSMHPNFDT-AP IIKKYNKLYPLHFIPHKEVLLRLTGIVKNPNNGIQKAFLNLISNYFGTLIETDDFDTELF ------------------------------------------------------------ QTEENAIKWVKMNGSVKKTNQTSDITPEDISMIQNFLKFNITEIERTKNKLEIAEKLSLF KDEEELKVLLDVPTPYSESERFIKLEPEEINGIQTFLKYNLAEFQKLRNCLIILKKLAIV TDEASVLYWMRINTSRPSKDNPKTMEPEEINMIQSFLRFNFDEILSFKASLNILRKILIF TDETKLLGWVTNENTKKTHGEKKSLKPEDINIIQSFLKFNVKELYNVLLNVKTLEKLLNF ------------------------------------------------------------ TDEASVLYWMRINTSKPSKDNPKTMEPEEINMIQSFLRFNFDEISSFKASLNILRKILIF TDEASILYWMRINTSKPSKENYKTMEPEEINMIQSFLRFNFDEISSFKASLSILRKILIF TDEASILYWMRINTSKSRKDNPKTMEPEEINMIQSFLRFNFDEISSFKASLNILRKVLIF ------------------------------------------------------------ YTESELSTWLRASMVKQKPNKRDKIEPEEIHSIQNFLKFSLTEFNYLREKFTVLKKLIIF LPASDLVNWIRESGRKRTNVSRQRIEPEEINSIQSFLRFNLSELSLIRDKISILQKLSIF EYTKETSIFESKQRIGKQSLGEVTYKLNQIQEIEYFLEYSLNNFQKYAYLFARLAKLVCI DSNLNL------SSSRSFTQNMKMMEPEEVRSIQSILKFNLSEISALKTAMLLMKKLAVF VKNRNKLTLELINDITKRKFSNLVLGIAQVNEIDFFLRFSLTDLVNFQTTIAKFNKLVAI EYSQETLILELKRKISKQSLGEITYKLSQIQEIEYFLEYSLSNFQKYAYLFSRLAKLVCI TNDEDELVLELKKKITKLKLGEVKLKVGQVQEIEYFLDYCLDEMRRAIQIFSKLSKVAII EYSKEVSILEQKQKISKQQLGDVTFKLNQIQEIEFFLEYSSNDLKKYTTLFNKLAKLVCI CQSDSTSVLDLMKEVSRLALGKVQLSVQNIQEIEYFVAFSREDLVKFQKSIAKLNKLVSI DRERLTLDFIQEASLRRANLGVVKLKSSQIDEIEFFLTFAISDLYKYKDALHKFGKLSAI HETLGLSSSGNSSSLDGKQESSSKVTPHQLAEIETFLSLSKENLLGTLSTTIKFNKLMTV KNPESLTKWIKAGKRKKKENYYKRMTLDDINMIKSFVQFNINELGKLNRTLAILKKLCTF ------------------------------------------------------------ SRLKSKDLLNSYVTIVSQLSSKYSAEDTKLLSAEKALSKITYLKICAQKLHNHILSITTM QQIKHRDVITMFLSLGNQMSQNTNC---AWSYSYYEFRNLEYLEHSVVTLLNNFESLLAK LSLKSSDFEDALLKMGTKVTNTIIKNHKMFSDLDELLEHVQFLEECTIQLFNSIQTILDR IHLKSIDVKESFVHLVKSIKNPIIEMQSLENQNNTLIDELDFLKACTLILTGNIEDILTQ ------------------------------------------------------------ LSLKSNDFEDTLREMGRKIINRIFTNHNMFSDLAELLEHVSFLEQCTIQLSTFVQTILDK ISLKSNDFKDVLNEMGKSIYNGNLTNHNMFNDLAKLLEHVRFLEECTIQLSNLVQLILEK ISLKANDFEDALNEMGKKLANGIITNHNMFSDLAELLENVRFLEQCTIQLSDFVQIILDK ------------------------------------------------------------ EHYKSHDIECSLYSQGEIIASRTSPFDNEFNDGIDPFQAVDFMCMCLDSLTSKIVEVLSK SELKAQDINQALFSQSVRLEDGISGLSEKDSESATILSNIDFLKECTNKLVGKIDQLLGK GDSKQVDCRNVIMYRFNKTTVDIFTYPEVNNQTLGVAEYFYWIQMHGDELLHSIQKLVSD EGLKGKDLSEACMTFGAKCKYHFLNVQAPNLF-FEGINNIALCELCSSLLCKHIGQVLDD SDIKQSDLRIVMFNCLFSSNINFALTNQYKNQSYKELTFTAWLELSTIELTKNIRRILLK GDSKQVDCKNVIIYRLNVTTVDIFTYPEVNNQTLGVAEYFYWIQTHGDELLNGIQKLVSD GEQKQIDVQNVLLYRFDV---TLTENETLVRVSLGNFDYLVWIELAGKELLKNIFKISAD GDIKQVDNNNVLIIRLDDSTIDAYIPPEVNDQNFGELDYIYWIQMFGDEVSKNINKLVLD GGVKQGDVRFVFLQSLFFVQQQLQAETEGRRLTYYAFSYIQRLESGVRELLASCDKVSQK ADMKQTDIRTVYLSALKKLVDKLKVPVEAEIQCWGGFSYVFWLQISLDELLKSVNKILEE MNIKMGDLNTISLYSAKMLCDTPSIKTNYHTPGYRTMQYFIWVELTLIEIIRNVNKVLGR LALKINDVNESFRNFGALLQQKIDGLIKPKYFIFLILDQISFLEICTIHMSDNFNDLIND ------------------------------------------------------------ ISNWWHIYGELLNAHKHYTRAFNRDLALHRMISNPKRIKLEERLSEKIKDITEQLNSVGH TTLWWKHFGELMELKKEWKKNFAPPSSAIDTYIEGKRSKFRNKLSNQLKMSSLNLKKIGG IPNWWKHYGEFLTLHKNYRKAFTSSHIPLGGFIETKREQSEQRLSVQIKASSKILKELGS IPNWWKLYGELLELNKHYNKLFVSNDVNFGGLIENQRNKAVKKLKTDIDQLKYSLEILGN ------------------------------------------------------------ ITKWWKHYGEFLALQKNYRKAFTPSHIPLGSFIETKREQSEQRLAVQIKASSKILKELGS IPNWWKHYGELITLHKNYRKAFTSGHIQLGGFIETKREQSEQRLAVQIKVSSKSLKELGS IPNWWKHYGEFLAVNKNYRKAFTSSHVPLGGFIETKREQSEQRLAVQIKASSKMLKELGS ------------------------------------------------------------ VSTWWTLYGEITNLQKEYQRNFEDSKGFFVSYMEDKRQKLESKLQSRLSVCSENLQHLDA LTRWWKLYAELLDARNQYNKNFDDNKGLFGTYVEGKRSKLEEKLSAQIKSCLERLQTLTY INSWKQMYYSICHINSELKLMEDDNLGFLSNFVGTSKKARYKKLVVEKSEIVKNIMKLNL IPKWWHTYGELLSLRREYKKSFSENSGLFGSYIETKRTKLEQSYAARINHTSVRLSEIST LDDWKELHKNIKELNIELTKYEAEEIADFFSFIIENKKARYKKLLLMKAEEIKKIMKLNA INSWKQMYYAICHINLELRQMEDDSLGFLSNFVGTSKKARYKKLVVEKSETVKNIMKLNS IQTWKDLYHAIYTINRDLRSMEDVPNTVEGIFLASSKRSKYKKLVVARADLVKQIMKLNV IKSWKEIYYAICHINSELRQIEEEDQGFLSNFVGTSKKTKYKKLIVDKSEAVKNIMKLNT LDQWKQMYHKIVDINVELRRFEEETSSPFFNFFIETKNSRYKKLLYSKSQSVQELMDLNV IRTWKELYSSIRELNSELHQIEDDTTSAFFNFIIESKKARYKKLLMTKSEKVKQIMKLNV ITDWRQCHDRVLSLAGELRKYEDKRHELHSNFIIENKRTRYKKLVLLHSEETKKLGLLSN IPEWHSVHFILSNLKKQYKRDFDSRNGLLSRYTKNKREAAEKRISEEIIENTTLFDKVTA ------------------------------------------------------------ DIKQMHELAAEEVSRFIDLKTKFTLYALQSYTISKQEHIEKDRMSNILSVFNPPPSRELD EIKTTHESIAVGINLFIEFKEQFYHHIVKSIVDQRIRENKQIMSSNITSLFNPPAQRDLT EIFSAHENLAEELSNYMEFRKACLDRTIVAFAIKNISVLQECIMSNILAVFNPPPQRELK EIFRKHEMLAEELNKYMEFKGVFFKAIIRNWRRGDLEAVNDDLMSNILSVFNPPQQRDLD -----HEVDTEKINIFQ--------------------------MSNILAVFNPPPQRELE EIFTAHEKLAEELSNYMEFRKACLDRTIVAFATTNIGIFQEYIMSNILAVFNPPPQRELE EIFVAHEKLAEELSNYMEFRKACLNRNIVAFAATNISVLQENIMSNILAVFNPPPQRELE EIFVAHEKLAEELSNYMEFRKACLDRSIIAFATTNISVLQECI----------------- ------------------------------------------------------------ ELKHCHELLAEEISFFISSKNFAYMFMVKAYVNRRIKQHKNMLVSNILSVFNPPPSRDLT EVKQEHEALAEELSIYLEFKTNYLRGIIQDFTVGKINTLKDTMSSNIISLFNPPPERDLP EIKWSHELIAAEISDFLKFRTEFLRFGIKRYISEEIKSLKQRSMSNILSVFNPPPSRPYP KINQDNERLAVELNNFINFKNEFLKSAIKEHADTNIKRLREQLQSNILSVFNPPAKRDLS ELKFDHECIAAEISNFLKFKSNFINLGIKRYVRLSLCLLKIRKMSNILSVFNPPPSRDIP EIKWSHELIAAEISDFLKFRTEFLRFGMKRYIVEEVKKLKQRNMSNILSVFNPPPSRPYP DIKWLHEIIATELSQFIKFRGRFLEFSTKLFVNEEMRSLRKRKMSNIRDVFFPPPARDIP EIKWAHEIIASEISNFLKFRTEFLRFGIKRYINEEVKNLKQRNSSNILSVFNPPKSGPYP RIKLDHEAIAAAISQFLTFRSGLMTFAIKQFTRTNLRVLRHRHMSNILGAFNPPPARDLS DIKWEHEVVASEISSFLKFRCDFLRFGVKTYVNSETKRIRNNSMSNILNVFNPPPSRPLT EIKISHEDIAAEMSHYLMFRSKLIPFAIKQFRVATTGLNRNGLMSNIADIFNPPASRPVV HIWYAHENLAEEFNKFLTFKSRFFKVILNMIIPSAIATLKDQVSSNILSVVNPPPQRDLD -------------------------------------------NSNILKVFNPPESRDLT ERDCVPCQVMSTVFGIGFGSYLVSGRAFKKKKGISLEKRNPMWWRRSLKGLGSIFIIMGL DRDCIPCQIMATAFSLGFGGYLASGKPFQKKKGVTVEKLNPKWWVSSARLFGGALIAFGI KMDCVPCQVMSTMFSVGFGSYLASGKPFKAKKGISLAKRNPQWWKLTLRSFGGLLIAFGF ELDCLPCQVMNSMLALGFGSYLVSGRAFKTKAGISLKKSNPLWWKSSVKGFGAGLIVYGI KMDCVPCQVMSTMFSVGFGSYLASGKPFKAKRGISLTKRNPQWWKVTLRSFGGLLIAFGF KMDCVPCQVMSAMFSVGFGSYLASGKPFKAKKGISLTKRNPKWWKLTLRSFGGLLIAFGF KMDCVPCQVMSTMFSVGFGSYLASGKPFKTKRGISLAKRNPRWWKLTLRSFGGLLIAFGF ------------------------------------------------------------ ------------------------------------------------------------ EKDCLPCQLMSSAFALGFGSYLLSGRAFRKAKGITLERYNPAWWRNSLRTVGGALVLLGV LQDCIPCQVMSTVVALGFGSYLLSGKAFEKKKGISFERRNPKWWRYSLKSLGGSLVVLGL PSECLPCTAIQSIVAIGGGLYLSSPNQFKKTTGKIDVTKNPLWWQRSVRGAGIILFGLGA DQDCIPCQVMSTVFSLGFGSYLISGKPFEAKRGITAEKMNPQWWRNSLRAFGGSLIVFGL DEPCLPCTAIQSLMSFAGGLYLNLNSLFKDLKGKINVHKNPIWWQNSVKSLGILLIGLGA PSQCLPCTAIQSIVAIGGGLYLSSPNQFKKTTGKIDLRKNPIWWQRSVRGAGIILFGLGA EEDCIPCNTVQALVAMGGGLWLASENQFRKSTGKIDAVKNPLWWRRSVRGLGLTLFVLGT QEQCLPCTAIQSFVALGCGFYLSSPNQFKKTTGKIDFVKNPLWWQRSVRGAGIILFGLGA SEDCMACTAIQSMVCFGGGGYFLSPMPFRNKSGLVDLKKHPVWFQRSVRGIGIGLIALGM EEGCIPCTAVQSVVALAGGVYLNSNTLFKPKTGKIDFAKNPIWWQKTVKGFGIVLFGLGA TDNCAPCTAVQALMCFGGGWYMSSGFPLQDKNGIIDVRKHPVWWQKSVRGVGVLLVGLGA NKDCIPCQIMSTMFSIGFGAYLVSGKPFERRRGVTMAKRNPKWWKGSLRGLGGTLIILGF PNECTHCQILQTVVLTGGGAYFASNMPFRVQPGQRLPPAATQAWQGGVRGLGFAMLAFGI ARGTEGWLWNKEKEMSKRGADNQLTREELDRDDISDEETPQATMASSDVISRRKIAMPKR YRGTEGWLWNKEKKMSKRFAGSQMTREGLESNNVSDDETPKPAVASESVMSTRKIAMPKR VRGTEGWLWHKNKEMAKRVADAQIQRETYDSNESDDDMNQ-TKVASSDVMNRRKIAMPKR VRGTEGWVWNKEKKMAKRIADSQISRESLEQGIASDDEMEHSKIASSAVMSKRKIAMPKN VRGTEGWLWHKNKEMAKRVADAQIQRETYDSNESDDDVTP-TKVASSAVMNRRKIAMPKR VRGTEGWLWHKNKEMAKRVADAQIQRETYDSNESDDDMTP-TKVASSAVMNRRRIAMPKR VRGTEGWLWHKNKE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ VRGTEGWLWNSDKYMAKRFAGSQITRETYEQSASDSEGETGPKLASALTMQKRKIAMPKR VRGSEGWLWNPEKEMSKRLADSQITRETFREDSDDSDNASGPKLATDAVMRNRRIAKPRK YRAGEQILYRKRFG----------------MPNYSDGEPDAPAIASSDVLSRRKILKPKG VRGSEKWLWNKQEPMESAGSPA----------------------------STAAVAQPNH YRAGELMVWNRKRNMSKRGASDQITRENH-LDHESDDEPKSIKLASASVLAKRKILKPRG YRAGEQILYRKRFGMAKRVADEQITKDGMS--NYSDNGPDAPAIASSDVLSRRKILKPKG YRAFEQAIYHGQSK---------------------------------------------- YRAGEQLLYKKKFGMAKRVADEQITKDGFEGSSDGDDAPQGPVQASNDVLSKRKILKPRG FRLGEQIWYRRRSGMAKRGAEEQITKDTFGASSDDERESSRPTFASEEVLSKRKILKPRG YRAGEQLVWKKKFEMSKRGATDQITKDNF-NERDDDDEPQ-VFKASAEVMAKRKIIQPKR YRVGEQMAWHRYKTMAKRTAEDQITRETYGTGEADDESFSGPSKASSAVMSRRKILKPRG VRGTEGWLWNKEKEMSKRNAGAQITREAFEEGNSDDDETPSFSMASSEVMSRRKIAMPKR YN---AWYFFSPKA---------------------------------------------- KMAFPSTLRGNTDESKTANAFSFLKKPQ----TEKTAANADDKPAKLKALNLQFKDKLEE KM-------GGFTAGDKPNMF------------KVIKDQGTDLNEKLTALNVQFKNKINS RMAFKPLATSASDESKIASSFNSLKQANNSE-AKADNDHITQNNSKLKALNLQFRTKIDE KK------MVFTQPKKDASAFN----AFGGLKKQTETD--EEKNNKLIALNLQFKDKIIA RMAFKPFGSAKSDETKQASSFSFLNRADGTGEAQVDNSPTTESNSRLKALNLQFKAKVDD RMAFKPFAPAASDESKTASSFNFSKQENNSG-TKADNDQTTQYNSKLKALNLQFKSKIDE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ KTSSA------SGGAGFGNAFAFVKRGAEEAAPAPATAPAGDQQAKLQALNMQLHEKVMH KMASFTISKTSSDESSTANAFSFAKPSRANVNRTNTIPNSSDTNAKLKALNLQFNKRVTE RLNTTGSNAFGAINKPPQSIFSFGGSPFNFANKPESNTASVDKDNKIKALNENFIQAITK ST---------------------------------------------------------- RTASSPAPSIGSNATGNSGLFGNATASFTFGSSQSSGK-SDDKNEKIKALNTQFVAILNK RLNSTGSNAFGALNGPQQPMFSFGGSPFNFAKKPESST--TDKDSKIKALNENFIRAITQ ------------------------------------------------------------ RLPSGGFNGFSNVQMPQSSSFSFGNGPFGSLKQQGSTTDEEEKNNKIRALNENFVKAVNK RN-----FSFKTDTAAVAEKPSFGVKPFAISKP-----SDDNKAAKLKALGQKFVESVNA RNASSSASSTPSVPVSGKPAFAGLNGSSTTNSSTSSSPAEAVKNNKIKALNNKLVLTLAS HRSTNTTPSFSTFKNETIPST-----GFTFGSNFASKNGESDKNERIRALNEQFIAAIKK KMAFK-LPTNNTDESKMAGAFNFSKKED-------NKNEIDDSSAKLKALNNQFSLKVSQ ------------------------------------------------------------ FLNSDPACDLRPVFMKYGKYIDEIKSSFTFTKPTTTVSDSKANADSSESDSDEKEIKITG TLESDPVADISFLFDKYKTYSQQLVTKPTTTVTEERLQDKKEEINSDSDSEEKPAVNVEG LVSSEPLADLRPFFTKYEEYIKSITESSKPTIQENGGRLGKVDDDQESSDSSDEEVKVEG VVKDDPCVDLNPLFAKYSNFRTSIVKPTLILSKPEAIKVDKSESSSSSSSESEDEVKVEG LVLGKPLADLRPLFTRYELYIKNIIENPTQT-KGNDAKPAKVEDVQKSSDSSEDEVKVEG LVSGEPLADLRPFFTKYELYIKNINENSKKSIQEDDNKSARVEEDIKSSDSSEGEIKVEG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AVREDPFVNLTPALEKYKKYLSSIVIKHDVGMACAGGAKQAEEDDSDAMSEEVKPVKVEG IISNDPFVNLTSIFRKYEAYIKDITPKATINTSQKTTTTAAAATASDESESDEKEIKVEG LNVPNTIADFTPIAQKYIDYYKSISTEPVSSSVPNEASKSETDSDSESESDKTKEVKVQG ------------------------TEKSASETKPGA------EEDSDSDEE----VKIQG NHKEGHVANFTEAAKKYIEYYDKIDDQPTPVVKPQPAVETKPESDSSSDSE--DEIKVEG LNVPNTIADFTPIAQKYIDYYKSITTKPISSSVQNEASKTENDSDSDSESDKAKEVKVQG ------------------------------------------------------------ LNVPNTIADFTTIAQKYIDYYKSISSKPAPSVESNTIKKDKSDSESDSDDDEKKDIKVEG VNVNQQIPDFRSIAKKYIEYYESVSGNTVPPASENGNAASQNDSEGEESEDEKKPVVIKG KNTEGTVANFTPLLNKYIQYYKDISKPIIPVVQEKKEEPIQVESDSDSDSE--DDVKVEG AEAPGTIADLTGVASKYINYYKDISQEPEGMEISGDDTKGKNENKSSDSDSEQDEIKIEG SISNDPFVDLSVLFDKYKEYLKSIPVPAFNNLKRTAEEENEEESSSSSDEDVKKDIKVQG ------------------------------------------------------------ PTFSISTKPITSDSVFAFGAAKKDDSDSESDVEIKGPEFKFAGEVKSDVFKLHK------ PKFVLAKKPTTSDPPFSFGGRK-PDSDSDSEIEIKGPQFTFNGTVSSSAFTLPKNDASRT PKFTINSKPITSDSVFSFGAKKEDESDSESDIEIKGPEFTFSGAVSSDIFKLNPSTEKSE PKFTLPTNPIIKDSVFSFGPQQPDDSDSESDIEIKGPQFTFAGKVESNVFKLPKSSNIDV PKFTIDAKPPISDSVFSFGPKKEDESDSENDIEIKGPEFKFSGTVSSDVFKLNPSTDKNE PKFTIDTKAPTSDSVFSFGPKKEDESDSESDVEIKGPEFKFSGTVSSDVFKLNANTDKNE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PKFVLAQGPTTKNPVFSFG-TKKEDSDSEDEIEVKGPTFTVSGNVSSGIFKLNKDSA--- PKFTISSKPTTEGSAFSFASKREADSDSESEVEIKGPQFKFSGTVSSDVFKL-------- PKFTLTSNPTTKSSPFTFDPLAKDSDDSEDDVEIKGPTFQFNKPIQDSVFKLTSNSADNT PSFTLTQKPTTSNPVFSFGARAADSSDSESEVEIKGPQFTFQASPSANVFKLKADSSSKP PKFTLNAKPTAKNSPFSFGPAKK-ESDSESEVEIKGPTFNFNKPIKDNVFKLDGAKSANS PVFTLTANPTTKSSPFTFDPLAKDSDDLEDDVEIKGPTFQFNKPIQDSVFKLTPNIANNT ------------------------------------------------------------ PKFTLATKPTVKSSPFTFDPLAKDSDDSEDEIEIKGPTFQFNKPIKDSVFKL-------- PTFTLSEKPTVKKSPFSFGPAKK-DSDSDSDIEIKGPTFTFNKTIADPVFKVQGADSKQT PKFTLTANPTTKSSPFTFDPLAKDDSDSESEIEIKGPTFTFNKPIKDAVFKLPSDKPANS PKFTFEAKPAKNSP-FSFDPAKKDDSDSESEVEIKGPVFSFNKPIKDSVFKI-------- PQFTLQSKPISKDSVFAFGSAKKADSDSESEVEIKGPQFTFSGAVKSDVFKLEEKEGKKE ------------------------------------------------------------ ---------KADENKNETKTDNSKVTENKAPTFSFGSTNTSGSKDENNSGSNEPAKQANT EESEPAEKPTDNKPASIFGNSS-----QSKPTFPPSASEKNEGSKP-ALPAFGSNKADNG KSTTEENKDKNPFSFTASTKENESDNVNIKPSFTFGTQDVVDTQNKKPSFTFGQTAAKPS SRNDEQNSQPQKTNEEKETNSTDASTNAVKPLFQFGSNTSNENKKDLNPFAFGKPLSQSE KSTTEQTKSKNPLSLTEATKTNVDNNSKAEASFTFGTKHAADSQNNKPSFVFGQAAAKPS KSAAEQTTDKNSFPSVGSTKENENKNDNVKSSFNFGTGAVVDSQNAKPSFVFGQTAAKPF ------------------------------------------------------------ --------------------TNVDNNNNVKPSFTFGAKNVADSHNNKPSFVFGQTTAKPL ---------------------------LAKPASSFGXT-------------------NTD ----------------------ENKAEQSAPIFSTKSD---EKSSSAAVTAFGGAAA--- ---KENAKVGSALSSNDSSKPAAKEQEKKPPAFSFSAPESAEKEEHKSAVSFAPGAAKDA SKLDEKKEEDEVKSTPLFGATTQDKDQTSTGLFGFGQNKGGET---KAPSLFGGSFGSNG EQAPAATADITPAQPGAAGKPAFNSSVSTKPSFNFGQSEEAPKEKPAFSFAFGTTKSEEA GNNSTSTQINDSKPAFTFGSSTAGKNDEPKPAFSFGASTAGKNDEPKPAFSFGASATKKD L--KSDEKKEEAKSTPLFGATTQNKDQIATQTSLFGSSEET-----KAPNVFGDSFGSNG ------------------------------------------------------------ ----PTTDSSKPFTFGEKKEDNNNDNDTKKPQNAFSLPSTSDKKEEKPLFGLSKPEDKPE GEDKSEKSKDNSSGKFSFGNSSSTSTSAPKPAFSFGAKAESKPVGEKPAFSFGSKPE-TT L---FNFGTTNDAAKSEEKKLEEPKPDEPKPAFSFTPTASTEKKDPLVPFSFGSASVNKD ----EPPKQTESAGKPRDTQSSTDSSTNAKPAFSFTAP--SESKPVQTTSAFGGGAS--- TQPVISFKKPDVGEQSKLSNPPTTSSDNKTPSFAFNTKDSIEKKEEE------------- ------------------------------------------------------------ VPKPAFSF-ESESSQEKKP--LSFNFTAPKTDNNEVESSTFSFGTKTNPFSGNTSGFSFG NSSSPFSFS----FSNNKD------LAKESENKKEEAKPASTFGSAPAPSADSKPSFSFS QPKSSFTFGKPENSGDINETKSSFTFSIPSKNTSDATKPSFSFGVPASSNAVSKPGLSFG TKTNPFSFSFGKTSGD--DNKPSFKFTSNPVPANDVNNPAFSFGKQSSMDKDKKPSFSFG LEKSSFTFGKPEKSSDSNDSNPSFSFSIPSKNTPDASKPSFSFGPNSSKNETSKPVFSFG QEKGFSTFGKTESSGDGNDTKPSFAFSIPSKN-PDAAKPSFTFGASTSPSGTAEPALSFG ------------------------------------------------------------ PEKSSFTSGKTEKSSDSNDTKPSFSFSIPSKNTSDASKPSFTFGVPNSSNEISKPASSFG TTKPLFNFG-QSNSQEEPPKKPTFSFGQPSSEGEPPKKPAFSFGPKPEEEAAKKPTFSFG ---------QEASLNGTTPTKPVFTFGVPSDKKPEAAKPSFSFGQADKTEKAEKPVFSFG ESKPSFSFSVGAEEKNTTTKKPVFAFGATSENSAQKTKPSFSFG-------------SSG NPVSTFSFGSSANTETKKTETPSFSFGTTNSS----SKPL--FG-SSNNEGNAKPAFTFG KPKPAFSFGAETEKSEGAKPKPAFSFGKPAETE---KSATFAFG--KTAQDSSAPSTSTA EPKPAFSFG--GSAEKKDEPKHAFSFGASAEKNDE-PKSAFSFGSATEKKDESKPAFTFG KPASSFSFGKTDASANTETKKPETTFSSGTTNSS--SKPL--FG-SLNNETNAKPAFTFA ------------------------------------------------------------ VAKPSFTFG----KPVEEAAKPSFTFGKPVEEA---AKPAFTFG-SASKSTDAKPAFSFG ENKPAFSFG---SKPATTENKPAFSFGSKPETTE--NKLAFSFG-SKPDVTDSKPAFSFG NDKPGFSHT-LTSSEEKKETQKHFAFNSTTAATAEPLQPTTLFGTASAKKDETKPTFSFG -NKPAFSFGSAAPQTTKVDQAPSFSFSAGKDSTT--NKPVFGFG-TQSSTVGQTSPFTFN ISKPNFAF-TEDKKNEAEAVKVSFAPSSSSSSNNENKKPTFVFGSNNATQSTSKPTFSFG ------------------------------------------------------------ KPASTSNTTE-------SKPSISFSKP---QNNDTVPKSAFSFGTSANTVTEEEKDSNTN APVQRTATENKDS----SKPSFTFGAMGKENSNDEAKKPSFTFGTSTSEKPA-------- SVALSTKEASKNDEKPVSKPAFGFLSNTDSAANEEVSKPVFSFGKTENESEGKPAISSGF VDKDNKVDDTPKPTSGESKPSFTFGNPKENASEVSVEKPSFSFGKTEKSEEK----SEEK AATPSAKEASQEDEKPSSKPAFNLISNAGTKESKKDSKPAFSFGISGSESKDKPSLPSAV SAKSPKRETNMNDDHIVEKPAFNLVSSIDNGENKEDAKPFFSFGKANGNESKSDNSAFSS ------------------------------------------------------------ AATSSAKETTEKDEKPAFTPAFNFMSNAGSRESKGDSKPLFSFGASGSESKDKTASPSAL QPKPEDGTSKKPS--------FNFGQPK--PEEEAAKKPSFSFGFKSTPASD-------- VSANQQNDKE-------DKPRFTFGTAA--EKNVENSKPT--FGAPTSDAKQ-------- ANTQPQEGSKSA---------FGTSTDISTGNNKNGKAPSFTFGTGSTNSTE-------- STTDKKDESASAT--ATTTPSFSFGTQPNKAKEAQGDKPATSFGNSSDNANKPATTGFSF TAVTSADDDQQKA---SAKP-FSFGGTSFSQKNNTSGPPSFSFGKTAQEPAE-------- ASAEKKDEPKPAVKKDESKPLFSFGTSATATEKKDEPKPAFSFGSSTEKKDE-SKPAFSF STTDKKDESATVTSSTTTTPSFLFGKQPNQAKEAQSDKPATSFGNSSDNANKSATTGFLF ------------------------------------------------------------ TPAATTTENKPDTSTNTTTPMFKFGAPSTTSTPSFNFKPQPTTATATDASAKSAPTTSLF NKTADSTGKPAFSEDSENKPSISFGTTNGSPAETGESKPAFSFGSKPTENTE-SKPAFSF ISNTNGEKNAEHTRAEQPKPLFSFNPPVS-SEKKTDSKPAFSFGSATSEKNDSQPSPFSF SNQSSVKISGKSDSSNSDKPSFNFSG----TSQSSETPSVFGTGSSINSAVQSGEKTNTT AASTATEGTKPSG--------FMFGGMKTEKKEEDKSKPSFMFGVQPKDTTK-------- ------------------------------------------------------------ GGN----EDSKPALNFNFSS-NTSSQKPSFSFGSTSEKKEETTSGGFSFGQ---SKAPAF -------ESSKPSFTFG---KASTGSTP-FTFGKQETDKKDEKKPTFTFGATAASTVPAF GSQNDKKEAAKPAFSFGTSTVDAGSKPPAFTFGSSIAGDKKEAKKPFSFGTASSNGAPSF SEEKSEEKSEQPSFTFGAGKTTSEAPKPVFSFQSMNDETTDATKPTFSFGNSS-TTAPSF DGENDKKEATKPAFSFGINTKTADTKAPTFTFGSSALADNKEVKKPFSFGTSQPNNTPSF ESGNDKKEKTKPAFSFGASASNTGSKPSAFIFGSSIATSSTEAKKPFSFGAASSNGTPSF ------------------------------------------------------------ DGENDKKEATKPAFSFGGNTETADAKAPTFTFGSSTLADKKEVKKPFSFSASRSNDTPSF ---ASEKSDNKSSFKFGQEKSQAENPKPIFSFGNPAPAANGEAKPAFSFGSSNSSTAPSF ------GVTSKPAFQFGTGTTNTAATPFGVKLPVADQSKQQNKPLSFSFGSST-AFLGTF ----------KPSFKFG---ATENKNGPA-------------ATPAFSFGSSTTASAPAF GAKTQEDKSEAPKFVFGSSKQGDSATTPSFNFGSNS------SNNAFSFGS---KPTGAF ------NTTAKSAFKFGTPGSSDATTEEQ---KTDSAEK---PKPSFTFGASSSSSAPNF GST----TNGENKVMFSGSSTKEEKPKSSLQFSFNPPSQTSSEKPAFSFGSSN-SGTP-- GTQKQEEESQTPKFTFGSSEQGDSTTPPSFNFGSNS------SNSAFSFGS---KPAETF ------------------------------------------------------------ GAV----SSDKPAFSFNSGAKTESTPTPAFNFNTSS------STATSTFGSN--KPTFGF GSKSAETNESKPAFSFGSKSSETPESKPAFSFGTTPSTEIKQTKPAFSFGSSQGSSSTGF GSASEKKNEVKPSLSFGSNNNNETSTKPAFLFSFNPTASSGSAKPAFTLG----STNGSS STATNNESKATPSFGFGITSTSSSNTPPSFNFGVKGSSDAATTKPAFTFGALNSAPSKPF ---SEITETNKP--------EEVEKPKPAFNFGGIKSSDADSSKPAFAFGSSISTSAPSF ------------------------------------------------------------ SFGTPATNTTTNNPPS------SGFKFSLPFNQENKSNEADSSKISEKKEDGNSATVETT SFGANKSEEAPPQGES------SGFKISLPFASSAPTSDKDTAKEVSEKNSEDASAEA-- SFGSTTNSPPKPLEAPAPSIPSTGFKFSLPFEQKGGQTFTGSNSKNEEPTTNMTATDPKD TFGKPKADDSIISNSTTSSIPSAGFKFSLPYEQKSPATSTTSSE-IPKDTDNTTGTTEVS SFGKTTANLPANSSTSAPSIPSTGFKFSLPFEQKGSQTTTNDSKE--ESTTEATGNESQD SFGKATTKSPPSSSTSTPSIPSTGFKFSLPFEQKVGQAATDEIVE--ESTIKAAGSDLQG ------------------------------------------------------------ SFGKTAANSPSNSSTSAPSIPSTGFKFSLPFEQKSNQTTTNDNRE--ESTPEAAGNDSQG SFPKPNNTNDSDSNGTTDNAPSGGFKFSLPFSQKPASQTSPSSSLSATPQQEESKPEEN- LLLWSETSGCFPSSRA------GGLRFSLPFAQDSKTLTTENIEQTEEATAAHEGANDQA SFGKPADSSSKEQRST----SSNGFKFSLPFAQGGSTLDKDGSKDTAKPSVEETNGEEQ- NFAQKQEDQKNETSSTSSSFGSTKPAFAFPFGSAKPEDKPEEKKNEETVPEEETGGKFEP SFGKSAESKPTDSKQESKPAPSGGFKFSLPFSSGSQPSTENKDVAQPKEASEETGAQDTK LFGKNNSTPSFTFNAN------------NNKNEAESNSATPETQQEADPSEEDTGGNFKA KFGEKQEDKKDEASSTSSSFGLTKPAFSFTFGSAKSEDKPEEEKNGDTVPEEETGGNFEP ------------------------------------------------------------ SFGKTDDKKPESKETA----------------------TAASEQPQQEEKEEETGGNFTP SFGSGATFNTSKANTASHEVAQKPLSFGFSKPAEGESESKETKESEEKVEEEDTGAEFAP VFGNSSATNAFSVEST-------------------TSESKDTDKDDDKVQEEETGGDFAP TFGSNSAAAQTPAFSF----GSNNVSNSFGSSNPNGLNKAADDKKEEEVVEEEVGGNFKP SFEKPASATSASTTATKPAVPSGGFKFSLPFEQKSGNDEAKTTAATTESTTTETGHENNE ------------------------------------------------------------ EEQSTSSSIQLQNGEEDETPLFTCRSKLMTINTKTNGYDSRGVGELKLLQKKDDKSKIRL -QEEPSKTLNLSNGEENENLLFSQRAKLMIFNTETKAYDSRGVGELKVLQNKEDNTKARI PASEESKPVDLQNGEEDEIALFSQRAKLMTFNSETKSYDSKGVGELKLLQRKDDPSKVRL TQDDNSSPMDLQNGEEDETPLFTQRSKLMVFNPETKGYDSRGVGDMKLLQRKDDKSKVRL ATPEESKPINLQNGEEDEVALFSQKAKLMTFNAETKSYDSRGVGEMKLLKKKDDPSKVRL AASEESKPMDLQNGEENEVALFSQRAKLMTFNVETKSYDSKGVGEMKLLRVKNDPSKVRL ------------------------------------------------------------ ATPEESTPINLPNGEEDEAALFSQKAKLMTFNAETKSYDSRGVGEMKLLRKKDDPSKVRL -KEEPSNPIEMQNGEENENLLFSQRSKLMIFNNETKSYDSRGVGELKLLQNKEDKSKVRF QGEPESEGIKMTNGEENEEVLFCEKAKLLIFDSDTKGYTSRGVGELKLLRKKDDKGKVRV -TQEPSQPMSMSNGEEDEDVLFAKRAKLLIFNSETKGYDSRGLGELKVLQRKDDKSKVRI VAKLSNEQVDSKSGEENETAKFTIRSKLMEYDSSENPYTNKGIGELKVLFNE-QTKKSRI PASEEGRSMVMSNGEEGEDLLFSKRAKLMVINPETKGYDSRGVGELKVLQNKDDKKKVRI VAQLSSEKLNNQTGEEDEEALYTKRSKLMLFDPSENPYTSKGLGDLKVLKNK-ATGKSRI VAKLSNEQVDSKSGEENETAKFTIRSKLMEYDSSENPYTNKGIGELKVLFNE-QTKKSRI ------------------------------------------------------------ IAKLSNEKIEQTNGEENEIVKFTIRSKLMEFDSKENPYINKGLGELKILYNE-KTAKSRI IASLGSQEVT-NTGEEDENVVYQRKSKLMLYDPKESPYKNMGVGELKLLSKK-DGSSSRI VAQLGSEKVESVSGEELEDTLYTKRAKLMLFDPKENPYVNKGVGDLKVLKNK-ETQKSRV IAQLSNTEVEVSTGEEDEEVLFTKRAKLMRFDPKEQPYASKGLGDVRILKSK--LGKTRI AEGEGSSGINMQNGEEDETVLFTQKAKLMTFNTETKSYDSKGVGEMKVLQKTDDKSKVRL ------------------------------------------------------------ LCRSDGMGNILLNTAVVKSFKYSPLTPENENLVKIPTIDKDGALVTYVARFKQKADGRLF LCRSDGMGHILLNTSIIKSFSYEALDPNNENLVKCPAIKAEGGLDTYVVKVKQKADGRKL LCRSDGMGNILLNATVVESFKYEPLAPENENLIKTPTVAADGKLTTYIVKFKQKAEGRSF LCRSDGMGNILLNTSVVKSFDYVPLSEKAENLVKAPVVEADGKLVTYVVKFKSQADGRLL LCRSDGMGNVLLNATVVDSFKYEPLAPGNDNLIKAPTVAADGKLVTYIVKFKQKEEGRSF LCRSDGMGNILLNATVVDSFKYEPLAPGNENLIKTPTVTADGKLITYIVKYKQKEEGRSF ------------------------------------------------------------ LCRSDGMGNVLLNATVVNSFKYEPLAPGNENLIKTPTVAADGKLVTYIVKFKQKEEGRSF LC---------------------------------------------------------- LCRSEGMGHVLLNTSVVKSFKYQPIDADNENLIKWPIIT-DGKLETFIIKVKQKADGRRL LCRSDGMGHILLNTSVVKSFQYVPLDSDKENFVKCPVVNSEGKLDTYIIRVKQKSDGRQL LIRADGSLRVLLNTLILSSVKYDSI--GNGSLIRVPTIDADDSIITYVIKVKTPQDGEQL LCRSDGMGHILLNTSVVKSFQYVPADADKENFVKCPVVNGNGKLENYIIRVKQKADGRQL VVRAEGGLRILLNTLVNKDMVYTTI--GNGSMVRVPTVNPTDKIETYILKVKTADDGQKL LIRADGSLRVLLNTLILSSVKYDSI--GNGSLIRVPTIDADDSIITYVIKVKTPQDGEQL ------------------------------------------------------------ LIRSDGSLRILLNTLILKSINYESI--GNGSLIRIPTIDPNDAIITYVVKVKTAENGSEL LVRADGGLRVLLNILVLKDVSYATM--GNGSLVRAPAVNSEGKIETYVLKVKTPADGKEL LIRADGGLRVLLNIAISKDMTYTQI--GNGSMVRIPTVNPLDTIETYVLKVKTPSDGADL LMRSEGSSRVLLNTLVSKTMTYTTM--GNGSMVRVPVLNNETKIETYVLKLKLATDGESL LCRSDGMGNVLLNSSVVKSFSFTPLAPEKDNLVKTPTIDSDGKLVTYIVKFKQKADGRLF ------------------------------------------------------------ VKSIEDAKN-------------------MKFSTI---AVTAALVAYSNASVLP---GEQQ VQAIKDAQS-------------------MKVAGI---IGSIAAANIVGASILP------- TKSIEDVKR--------------MHFSLKHLAIA-------AFAANLGSAYVI-----PQ VKSIEDAKK-------------------MKIVFGSLVSTGLLTAALVDAYRLP------- TKAIEDAKK--------------MHFSLKQLAVA---A---FYATNLGSAYVIPQF---- MKAIEDAKK--------------MHFSLKQLAIA---A---FYATNLGSAYVIPQF---- -----------------------MHFSLKQLAIA---A---FYATNLGSAYVIPQF---- MKAIEDAKK--------------MHFSLKQLAIA---A---FYAANLGSAFVIPQF---- ------------------------------------------------------------ VGAVADAQQ-------------------MKYFKLVLTAGACAQAFLVPERWA-------- CTAISNVQS--------------------------------------------------- LKCINELK-----------------MKFLTLTTS---LSIIVSINALPTSFGF------- CQALSDAQA-------------------MRISTL---L---VTTASCVQAFVL------- LEVLNDARK-------------------MKFSLT-TSLALVTAINALPLTNI-------- LKCINELK--------------------MKFLTLTTSLSLIVSINALPTSFG-------- ----------------------------MKITFL---TAVAAALVTLPNANA----FPAL LKTINELK-----------------MKFLTLAAS---VTLISSINALPTSMSF------- CDALNQIKN-------------------MRLAAT-TLLAILGTVNSLPVGIE-------- LKHLDDNKL-------------------MKINTL---TLSASLSILTAINSLP------- SKLLEEVKS-------------------MKFSTV---LAIAVALSTTAAVPV-------- IKSIDEAKK-------------------MKVLVS---L---GLAVGLANAIVV-----PE ---------MTPSYQATVVTPSTSPHFTHNIKMK---FLSLAAAASLATAAF-------- AFDLSALKETKETDWDSIISGVKDALSQGHSEQDAAEVYEDDDEDVSPCKKSFWSFLWKP -------------------------QYIQEVFSTGEVSESLQNLSDFFEDGSKSSVFTWP FFQEAFKQEDPIQYLPEQK----------------------ETHDDDNSVVGATIP--KP -----------------------------TFLQESFEALDSEDKLQIEPHNSEDSSNWKP -FQEAFQQEEP-IENYLPQ-----------------------LNDDDSSAVAANIP--KP -FQEAFQQEEPLIENYLPK-----------------------LNDDDNSVVGANIP--KP -FQEAFQQEEP-LENYLPQ-----------------------LNDDENSIVDANIP--KP -FQEAFQQEEP-IENYFPQ-----------------------LNDDENSVVGANIP--KP ------------------------------------------------------------ -----------------------------------DAMAEAIAPVARNPLLFNEEPKLVP ------------------------------------------------------------ ------------WKNWFNLGEELAQEVIMDDISDQFINNDENENNNNDNNLIIDGV--ID -------------------------------------PQAFLEVFIEPQSLEPESL--WP --------------------FPQSILNLPIFNSIDNEHTNLGYLSELEGIVSSINEETLD --------------------FWKNWFNLGEELTQEIIMDDISEQLINNDDKNLIIDGVID RFWNNVLSTPTGMDDSILIDVKEAPQHEFAGSGFTKGVASGNEEVYNVDFESFQQENILD -WRNWFNYPAELIEDTIID-------------------SISNLDSHQEDYMIIDSV--MD ---------------------------------------SVIEKSQDVLAIGDQVKSFPF ----------------------------------FDLKQLQQSFQLNVPGLELDGTPLKD ------------------------------------------------TQKVFDIDANVD FIQQVFRLEDDYLSSQLEE---------------------LTTAASESNEPSFKNW--LP ------------------------------------------------------IPEQNP HVPYL-----------------LKPIVES--DKLQDKIEL-------D----DLNKTAHD HLPYF-----------------LKPGVDS--EKLQDSITI-------D----QLNDTAWD HVPYF-----------------MKPHVES--EKLQDKIKL-------D----DLNATAWD HVPYF-----------------LKPTVDS--NKLQESIRL-------E----DLNATAWD HIPYF-----------------MKPHVES--EKLQDKIKV-------D----DLNATAWD HIPYF-----------------MKPHVES--EKLQDKIKV-------D----DLNATAWD HIPYF-----------------MKPHVES--EKLQDKIKV-------D----DLNATAWD HIPYF-----------------MKPHVES--EKLQDKINV-------D----DLNATAWD ------------------------------------------------------------ DLFRQ-----------------DKPLVSS--EKLQEMITV-------G----QLNSSAWE ------------------------------------------------------------ ETVYN-----------------SLPEIDT--ESLQSLINE-------K----GLRSRAED HKPYF-----------------LKHGVNP--ETFPDEIKL-------E----ELNATAWD EGKYK-----------------DLPLIET--EKLQELINE-------K----GLRNRAEK ETVYN-----------------ALPEIDT--ETLQSLINE-------T----GLRSRAKD ESVYK-----------------KLPEIDT--EELQSLVNK-------K----GLRERAET ETEYL-----------------SLPLIET--EDLQSLINE-------E----GLRLRAET PWPHW-----------------GKPEIDT--EKLQSDITE-------E----GLRERAEK APEFSKQDFN------------ALPEIDT--EQLQALINE-------A----GLKSRAET AMQLF-----------------EKPEVDS--EQLQSLITD-------E----AISLHAEK HLPYF-----------------FKPTVDS--QKLQDAITV-------E----ELNATAWD MALLK-----------------EKPLVTS--EELQKHISE-------K----GLRHRAEH LLKIAKKSKKKFGHPTRVIGSPGHGKTIDYILDAFD----DMK--DYYDVSVQEFDA--L LYHAANASTKQYGHPTRVIGSKGHWKTIGYILSQLD----EHK--DYYDISVQSFPA--L LYHMANHSTSEYGHPTRVIGSKGHNKTMEYILNAFD----DMQ--DYYDVSLQKFDA--L LYHIAESSKKEYGHPTRVIGSPGHWNTIGYILACLD----NMK--DYYDVSVQTFNA--L LYRLANYSTPDYGHPTRVIGSKGHNKTMEYILNVFD----DMQ--DYYDVSLQEFEA--L LYHLANYSTPEYGHPTRVIGSKGHNKTMEYILNAFD----GMQ--DYYDVSLQNFDA--L LYHLANYSTPEYGHPTRVIGSKGHNKTMEYILNAFD----DMQ--DYYDVSLQQFDA--L LYHLANYSTPEYGHPTRVIGSKGHNKTMEYILNAFD----DMQ--DYYDVSLQEFEA--L ------------------------------------------------------------ LYRIATMSTPEYGHPTRVIGSAGHNGTVEYILEELG----KLG--DYYDVSVQNFGA--L ------------------------------------------------------------ LFEIAQRSIGKYDHPTRVIGSPGHWGTIGYIISEIK----KLK--GYYNVKTQSFKA--L LYHLAEASNRTFGHPTRVIGSPGHWKTLNYILDQFE----EMR--DYYDVSLQSFKA--L LYNISLNSVSEYGNPTRVIGSPGHWGTIHYIINELK----KLN--GYYKVSTQKFDA--I LFEIAQRSIGQYDHPTRVIGSPGHWGTIGYILSEIK----KLK--GYYTVKTQSFKA--L LFNLAGKSNETYGHPTRVIGSPGHFATVHYIIKELR----KLG--GYYNIITQSFKA--I LFGLAQQSVAKYDHPTRVIGSPGHWATIGYIIAELK----KLK--GYYSVKTQSFKA--L LYSIAKASTDEFGHPTRVIGSPGHWGTVNYILQEME----KMS--DYYSVDVQHFDA--V LFSIAERSKADYGHPTRVIGSAGHWGTIDYIKAELA----KLR--GYFTFDVQAFFA--V LYNISKKSIKQYGHPTRVIGSKGHWKTIAYILSELK----KLK--GFYHVSTQKFPA--L LYRIAESSNKTFGHPTRVIGSKGHRKTIKFLLDAFD----EMK--DYYEVSLQSFKT--A LFKLAEKSENEFGHPTRVIGSEGHRKTLKYIIDSLK----KFN---YYHLSMQPFDA--V AGKI-RSYNLTDAKTGKTFKNTTAFALSPP-----VKPFVGRVIEIP-----N-LG--CH TGKVNSFNLSFVG--GDKVPTATPFALTPP-----VKGFLGKLIEIP-----N-LG--CD SGKI-ISFNLSDVETGHTFANTTAFALSPP-----VDGFIGKLVEIP-----N-LG--CA SGKI-NSFNLSDAKTGETFDNTTAFALSPP-----VAPFIGQVIEIP-----N-LG--CK SGKI-ISFNLSDAETGKSFANTTAFALSPP-----VDGFVGKLVEIP-----N-LG--CE SGKI-ISFNLSDAETGKSFANTTAFALSPP-----VDGFVGKLVEIP-----N-LG--CE SGKI-ISFNLSDVETGQSFANTTAFALSPP-----VDGFIGKLVEIP-----N-LG--CE SGKV-ISFNLSDAETGKSFANTTAFALSPP-----VDGFVGKLVEIP-----N-LG--CE ------------------------------------------------------------ VGELRSYNLTYMN--DTEVPWSNVLHYSPS-----VELFQGKLLHVP-----N-LG--CD ------------------------------------------------------------ DGKV-KSFSLLID--GVEPKSLSPFSLTPPTAD--GKPAHGNLVLVD-----D-FG--CK NGKV-SHYDLNFT-NGEAVPSAQAFSLSPP-----SAPFVGKLVEVP-----N-LG--CS DGKVNSFSLLIDG---VEPRSLEPLGLTPPTPD--KKPVHGNLVLVE-----E-FG--CS DGKVKSFSLLIDG---VEPKSLAPFSLTPPTAD--GKPAHGNLVLIN-----E-FG--CK DGHVESFSLLIDG---IKPKSLQALALTPPTPN--KAPVHGDLVLVL-----E-NG--CS DGKV-KSFSLLID--GIQPKSLAALSLTPPTPD--GKPVHGNLVLVE-----G-LG--CN YGKVNSYSLLIDG---VEPKSLSAFSLTPPTPH--KAPVHGNLVLVE-----N-FG--CD DGKVNSYSLLVDG---TEPKSLLPLSLTPPTPN--GRPVHGKLVLVE-----N-FG--CS FGKINDYSLLIDG---ISAKSVKAFDLTPPTRA--EKPVHGKLIVVA-----N-YG--CF MGKV-NSFELVDPSTGEVFQNVTAFDLTPP-----VDKFEGRVIPIL-----N-MG--CE AGNVLESKLVIGG---EVPKSSAPFSLTPGTPD--REPVYGNITVAL-----N-EG--CD EKDFAAVH-----RKGSKHKHDIALIERGECP----FGVKSDLAGKYGFHAVVIYDNEP- DIDYKSLV---------VPKNSIALIERGQCP----FGRKSNLAGKHGFKAALIYDNDP- EKDYASLV------PPGLNEKQIALIERGKCP----FGDKTNLAGKYGFSAVVIYDNEP- EADFDAVAPPSGVMSDGSEKKRIALIERGHCP----FGNKSNLAGKYGYHAVIIYDNEP- EKDYASVV------PPRHNEKQIALIERGKCP----FGDKSNLAGKFGFTAVVIYDNEP- EKDYASVV------PPGRHEQQIALIERGKCP----FGDKSNLAGKFGFAAVVIYDNEP- EKDYASVV------PPGRNEKQIALIERGKCP----FGDKSNLAGKFGFTAVVIYDNEP- EKDYASVV------PPGHNDKQIALIERGKCP----FGDKSNLAGKFGFTAVVIYDNEP- ------------------------------------------------------------ EDDYRALV---------VGANEIALIERGECE----FRRKSILAGTFGFKAAIIYNNDP- ------------------------------------------------------------ PDNFPEFT-----------KGNIVLIKRGECA----FGDKSRNAGIAGALGAIIYDDEP- DADFEALE---------VSIDSIALIERGECP----FGRKSDLAGKYGFRAAVIYDNDP- LENFPKFT-----------KDNIALIKRGNCA----FGDKSINAGLSGALGAIIYDSDG- LDNFPEFA-----------KGNIVLIKRGECA----FGDKSRNAGIAGALGAIIYDDEP- LHDFPLNA-----------KDNIVLIQRGQCS----FGDKSRNAGKVGALAAVIYDSNG- VSDFPDFT-----------KGNIALIKRGECP----FGDKSKNAGEAGALGAIIYDEEP- ISDFPANI----------TKGNIVLIGRGECA----FGVKSVNAGKAGAVGAIIYDEDA- VEDFPKYT-----------KDNIALIKRGECA----FGDKSINAGLAGAAGAIIY----- ASDFPAAS-----------ADNIVIIKRGECA----FGTKSINAGNAGALGAIIYDPSP- KSDFELTFCKGHKGHKSGKSGKIALVQRGICP----FSVKSQLAGKFGFDAVIIYDNEK- VNDFE------------NVKGTIVLVRRGTCP----FGDKSANAGKRGAIACVIYDSEP- -LSLDGLKGT----LGAP--TN------------HTVSTIGVTYVTGKEIIAKLAF---- -LSKDGIKGT----LEKP--DK------------HTVATIGVSYKEGKKLIAALELHQ-- -KSKGGLHGT----LGEP--TN------------HTVATVGVPHKVGKELIANIAL---- -ESVGGLHGT----LGEP--TN------------ETVSTVGVTFDVGMQLIDSISL---- -KSKEGLHGT----LGEP--TK------------HTVATVGVPYKVGKKLIANIAL-NI- -KSEDGLHGT----LGEP--TK------------NTVAAVGVPYKVGKKLIANIAL-NI- -DSKEGLHGT----LGEP--TK------------HTVATVGVPHEVGKELIANIAL-NI- -KSKDGLHGT----LGEP--TK------------HTVATVGVPYKVGKELIANIAL-NI- ------------------------------------------------------------ --EEGGISGT----LGNPDE--------------HMISTFGVSYDVGNSLVAAISL---- ------------------------------------------------------------ ------VRGT----LGNP--TG------------KEVATVSVVKKDVEKYIEKLSK---- -NSEKGVSGS----LEKP--TN------------NTVSTIGVSFAVGQKLITKIEK---- -----PLHGT----LGTP--TG------------HEVATVSISEKDAKDYIDALLK---- ------LRGT----LGNP--TG------------KEVATVSVAKKDVQEYIDKLSK---- -----PLLGT----LGTP--NG------------EEVPTLAVSEKDVADYIDKLQK---- ------LHGT----LGNP--TG------------KEVATVSVATKDVKEYIEKLTA---- -----PLHGT----LGEP--TG------------DEVPTVSISKKDAQHYIDVLSK---- -DPEGALHGT----LGSP--TG------------KEVPTLSISEKDAAHFVKVLSK---- ------LAGT----LGDH--TG------------NEVATVSITEKEAKPYLEKLEA---- -KTSGGLRGT----LGTP--NK------------NSIATVGVTNEVGRTILDSVQN---- --GDNTVSGT----LGEPNE--------------HHVATFGISNNDGVKYIEDLAN---- -----DPDYSLYFAMDSYVG-KIKTKNIIADTKH---GDENNIVGLGAHSDSVE------ --G----DYSLYFEVDSFVK-NIKTKNIIADTKH---GDPENIVALGAHSDSVS------ NID-----YSLYFAMDSYVE-WIETQNIIADTKH---GDPDNIVALGAHSDSVE------ -----DEDYSVYFAMDSYVK-NITTKNIIADTKR---GDEKNIVALGAHSDSVE------ --D-----YSLYFAMDSYVE-FIKTQNIIADTKH---GDPDNIVALGAHSDSVE------ --N-----YSLYFAMDSYVE-WIRTQNIIADTKH---GDPDNIVALGAHSDSVE------ --N-----YSLYFAMDSYVE-WIKTQNIIADTKH---GDPDNIVALGAHSDSVE------ --N-----YSLYFAMDSYVE-LIKTKNIIADTKH---GDPDNIVALGAHSDSVE------ ------------------------------------------------------------ -----DPTFSLNAMVDSTVK-EITTQNVIADTKG---GDPENIVSLGAHSDSVF------ ------------------------------------------------------------ --D-PKYAFETTLYVDSYVK-YIKTLNVIADSVF---GDHDNIVSLGAHSDSVA------ DPN-----FSLFFFMDSYVA-EIVTKNIIADTKH---GDPENIVALGAHTDSVA------ ---DPTHVFETTLYVDAYVK-NITTLNVIAESTY---GDHDNVVSLGGHSDSVS------ ---DPKHAFETTLYVDSYVK-YIKTLNVIADSVF---GDHDNIVSLGAHSDSVA------ ---NPNHKFETTLFIDSYVK-NISTLNVIAETKF---GDHNNVVALGAHSDSVG------ --D-PKHKFETTLYVDSYVR-YIKTLNVIAETVF---GDHDNIVSLGAHSDSVA------ ---KPHHQFETTLFVDSYVK-TINTINVIAETRG---GDHNNVVSLGAHSDSVT------ ---HPHHKFKTTLYVDSYVK-NIRTLNVIAETRF---GDHDNVVSLGAHSDSVT------ ---DPEAEIEVTLYVDAKVE-IVHTLNVVAETVD---GDHDNVVALGAHSDSVG------ NPK-----YSLSLYVDAYVK-NIKVNNVIADTIH---GDPENIVGLGAHSDSVE------ -----KGHLEGSAYVDGYVK-TVKTYNILAETIE---GDPENVVCLGAHSDSVT------ -EGPGLNDDGSGTISLLTVAKQLTHF------KINN-KVRFAWWAAEEEGLLGS--NYYA -NGPGINDDGSGAISLLTVAKQLTGY------KINN-KVRFAWWAAEEEGLLGS--VFYA -EGPGINDDGSGTISLLNVAKQLTHF------KINN-KVRFAWWAAEEEGLLGS--NFYA -EGPGINDDGSGTISLLTVAKQLTHF------KINN-KVRFAWWAAEEEGLLGS--NYYA -EGPGINDDGSGTISLLNVAKQLTHF------KINN-KVRFAWWAAEEEGLLGS--NFYA -EGPGINDDGSGTISLLNVAKQLTHF------KINN-KVRFAWWAAEEEGLLGS--NFYA -EGPGINDDGSGTISLLNVAKQLTHF------KINN-KVRFAWWAAEEEGLLGS--NFYA -EGPGINDDGSGTISLLNVAKQLTHF------KINN-KVRFAWWAAEEEGLLGS--NFYA ------------------------------------------------------------ -AGPGINDDGSGTISLLTVAKHLANF------SVKN-KVRFAWWSAEEEGLLGS--EYYV ------------------------------------------------------------ -EGPGINDDGSGTISLLEVAKHLTQF------KLNN-AVRFAWWAAEEEGLLGS--TYYA -AGPGINDDGSGTISLLTVAKHLSDF------KINN-KVRFAFWSAEEEGLVGS--NYYV -AGPGINDDGSGSISLLEVAKHLTNF------RINN-GVTFAWWAAEEEGLLGS--YHYA -EGPGINDDGSGTISLLEVAKHLTKF------KLNN-AVRFAWWAAEEEGLLGS--TYYA -EGPGINDDGSGTISLLEVAKYLTKF------KINN-AVRFAWWAAEEEGLLGS--DYYA -EGPGINDDGSGTISLLEVAKYLTNF------KVKN-AVRFAWWAAEEEGLLGS--TYYA -EGPGINDDGSGTISLLEVAKHLSKY------KVKN-AVRFAWWAAEEEGLLGS--YAYA -EGPGINDDGSGTISLLEVAKYLSQF------KVNN-AVRFAWWAAEEEGLLGS--DHYA -AGPGINDDGSGTISLLEVAKQLTKF------KVNN-AVRFAWWAAEEEGLIGS--NYYA -EGPGINDDGSGLISLLTVAKHLSHY------KVNN-KVRFAWWAAEEEGLVGS--NYYA -EGPGINDDGSGTISLLETAIALTNF------KVKN-KVRFAWWAAEEEGLLGS--NYYA NSLS--KEENLKLRVFMDYDM--MASP-NYEYEVYDANNTV-----NPP---GSQELRDL DHLS--PEENSKIRLFMDYDM--MASP-NYEYQVYDANNKD-----HPA---GSKELKNL FNLT--KEENSKIRVFMDYDM--MASP-NYEYEIYDANNEE-----NPK---GSEELKNL NHLT--AEDNLKLRVFMDYDM--MASP-NYEYEVYDANNID-----NPK---GSEELRDL YNLT--KEENSKIRVFMDYDM--MASP-NYEYEIYDANNKE-----NPK---GSEELKNL YNLT--KEENSKIRVFMDYDM--MASP-NYEYEIYDANNKE-----NPK---GSEELKNL YNLT--KEENSKIRVFMDYDM--MASP-NYEYEIYDANNKE-----NPK---GSEELKNL YNLT--KKENSKIRVFMDYDM--MASP-NYEYEIYDANNKV-----NPK---GSEELKNL ------------------------------------------------------------ SQLS--PEENQKIRLFMDYDM--MASP-NYEYEVYDANNRE-----NPA---GSEELKNL ------------------------------------------------------------ EHLT--AEENSKLRLFMDYDM--MASP-NYEYQVYDANNKD-----HPN---GSGNLKDL EQLT--PEENQKIRLFMDYDM--MASP-NYQFQVYDANNVD-----NPK---GSEELKNL NTLT--PEQNSKIRLFMDYDM--MASP-NYEYQVYDANNED-----HPN---GSGDLKDL EHLS--AEENSKLRLFMDYDM--MASP-NYEYQVYDANNKD-----HPN---GSGNLKDL NNLS--EEENSKIRLFMDYDM--MASP-NYEYGIYDANNKD-----HPD---GSGNLKDL EHLS--PEENAKVRVFMDYDM--MASP-NYEYEIYDANNEE-----NPK---GSGDLKDL NSLS--DEENQKIRLFMDYDM--MASP-NYEYQVYDANNED-----HPD---GSGDLKDL NSLS--PEENSKLRLFMDYDM--MASP-NYEYEVYDANNKD-----HPN---GSGTLKDL ANLS--PEENQKLRVFMDYDM--MASP-NYELQVYNANNED-----HPA---GSGDLKQL NSLS--PAENQKLRVFMDYDM--MASP-NYEYEVYDSNNKD-----HPK---GSEELKNL NNLT--PEENQQIRLFMDYDM--MASP-NYAYQIYDANNKE-----NPE---GSEELKQL YINYYKDQGLNYTLIPFDGRSDYVGFIEN-GIPAGGIATGAEKKNVFN---------GGV YIDYYQSKNLTYSLIPFDGRSDYVGFINH-GIPSGGIATGAEGINDEN---------GLP YVDYYKDHDLNYTLVPFDGRSDYVGFINN-GIPAGGIATGAEKNNVDN---------GKV YIDFYKQNELNYTLIPFDGRSDYVGFIEN-GIPAGGIAAGAEKDNVFN---------GEV YVDYYKAHHLNYTLVPFDGRSDYVGFINN-GIPAGGIATGAEKNNVNN---------GKV YIDYYKAHHLNYTLVPFDGRSDYVGFINN-GIPAGGIATGAEKKNVNN---------GKV YIKYYKDHHLNYTLVPFDGRSDYVGFINN-GIPAGGIATGAEKNNVDN---------GKV YIDYYKAHHLNYTLVPFDGRSDYVGFIEN-GIPAGGIATGAEKKNIDN---------GKI ------------------------------------------------------------ YIDYYTSHGLNYTLVPFDGRSDYVAFIQN-GIPGGGVATGAEKINALN---------NDP ------------------------------------------------------------ YIDWYTSHGLNYTLTPFDGRSDYVGFIEN-GIPGGGIATGAEGVKDAKGQEKFGGKVGEW YIDYYTSHGLNYTLIPFDGRSDYVAFIDH-GIPGGGIAAGAEGPNTDN---------GGV YIDWYTSHGLNHTLVPFDGRSDYVGFIDH-GIPAGGIATGAEGIKTPDGKEKFGGEIGKW YIDWYTSHGLNYTLTPFDGRSDYVGFIEN-GIPGGGIATGAEGIKDAKGQEKFGGKVGEW YVDWYEQHGLNYSLMAFDGRSDYVGFIDN-GIPAGGIATGAEGVKDKKSKEKFGGKVGEW YINWYKDHGLNYTLVPFDGRSDYVGFIDA-GIPAGGIATGAEGVKDTKSQEKFGGKVGEW YIDWYLAHGYNYTLVPFDGRSDYVGFIDV-GIPAGGIATGAEGVKTKKGAKKFGGEAGKW YIDWYTQHGLNYSLVPFDGRSDYVGFIDN-GIPAGGIATGAEGVKSPEAQKKFGGEAGKW YIDYYVSHGLNYSLTPFDGRSDYVGFLET-GIPSGGIATGADEYKTPEEQAKYGGEVKKW YIDYYKSRGLNYTLIPFDGRSDYVGFIEN-GIPAGGIAAGAEKDNVFN---------GGV YIDFYEREGLNYTFIPFDGRSDYVGFIDN-GIPGGGIATGAEGVKTDEEVEQFGGKAGDW LDKCYHQL-CDDISNLAWDAFLVNTKLIAHSV--------------------------AT FDKCYHSL-CDDVSNLAFDAFLVNTQLIAHSV--------------------------AT LDRCYHQL-CDDVSNLSWEAFVTNTKLIAHSV--------------------------AT LDKCYHQL-CDDVSNLAWDAFMVNTKLIAHSV--------------------------AT LDRCYHQL-CDDVSNLSWDAFITNTKLIAHSV--------------------------AT LDRCYHQL-CDDVSNLSWDAFVTNTKLIAHSV--------------------------AT LDRCYHQL-CDDVSNLSWEAFITNTKLIAHSV--------------------------AT LDRCYHQL-CDDVSNLSWDAFITNTKLIAHSV--------------------------AT ------------------------------------------------------------ FDKCYHQL-CDDTGNLNFEAFMVNTKLIAHAV--------------------------AT ------------------------------------------------------------ FDPCYHQL-CDNLDNPDYEAWVINTKLIAHSV--------------------------AV LDRCYHEL-CDDVSNLNWEAFLTNTQLIAYSV--------------------------AN FDPCYHQL-CDDLSNPSYEAWIVNTKLIAHSV--------------------------AV FDPCYHQL-CDNLDNPDYEAWVINTKLIAHSV--------------------------AV FDPCYHQL-CDDLSNPSYEAWEVSTKLIAHSV--------------------------AV FDPCYHQL-CDNLDNPHYGAWVNNTKLIAHSV--------------------------AV FDPCYHQL-CDDLKNPDYEAWVVNTKLIAHSV--------------------------AT FDPCYHQL-CDDLSNPDYEAWVINTKLIAHSV--------------------------AT LDPCYHQA-CDDLSNPDHEIWLLNTRLIAHSV--------------------------AT LDKCYHLL-CDDVSNLSMEAFMVNTQLIAHSV--------------------------AT YDPCYHQL-CDDLSNPSYEAWLVNTKLIAHSV--------------------------GV YANS--FEGFPER--IGSNKTIS---------------------------ALQAPSF-PY YAKS--LEDFPQR-----------------NLNV---T------------SENVADF-SY YADS--FEGFPKR---EIHKH--------KELTA---L------------NAEQPQF-KY YAKS--FEGFPER---ETNAT--------LSASS---R------------KDQTPLF-KY YADS--FEGFPKR---ETQKH--------KEVDI---L------------NAQQPQF-KY YADS--FKGFPKR---ETHKH--------QDVNA---L------------NAGEPQF-KY YADS--FKGFPKR---ETHKH--------EEVDA---S------------TVRQPQF-KY YADS--FKGFPKR---ETHKH--------EEVDV---L------------NTQQPQF-KY ------------------------------------------------------------ YGAS--LEDYPLR-STDGLMTLAA--------------------------TTQSPRF-HY ------------------------------------------------------------ YAKS--FEGFPKR-EPKKEVASASN-------------------------SE-KPNEFIY YADS--LKGFPER---EVNAT--------FTVSS---T------------ESRPKYF-YN YANS--FKDFPEREATV----------------------------------TTKSSDFKF YAKS--FEGFPKR-EPKKEVASASN-------------------------SA-KPNEFIY YAKS--FEGFPTR--KSKKESMPEAEEASIEQNS----------------I-TQSQF-IR YARS--FDGFPKR-EPKTDVAIAAT-------------------------SELNNNKFIY YAKS--FDGFPER-DVKNVASISSV--------------------------K-PSDTFKY YAKT--FEGFPER-ENATEASISEA-------------------------GK-KKSNFKF YAKS--FDGFPER--VPLNE--------TVAAAS----------------V---DRM-PY YAKS--FEGFPER-----QTN--------ATLNN---V------------ANESLLM-KY YAES--FKGFPKR--KE-VK--------KDTVKV----------------EGMTPKY-KY R-------------------GSNLII---------------------------------- R-------------------GSHLIL---------------------------------- R-------------------ADFLII---------------------------------- R-------------------ADKLII---------------------------------- R-------------------ADFLII---------------------------------- R-------------------ADFLII---------------------------------- R-------------------ADFLII---------------------------------- R-------------------ADFLII---------------------------------- ------------------------------------------------------------ K-------------------GNSLIY---------------------------------- ------------------------------------------------------------ R-------------------GSKLIM---------------------------------- G-------------------GANLIL---------------------------------- R-------------------GSKLIV---------------------------------- R-------------------GSKLIM---------------------------------- K-------------------GDKFII---------------------------------- R-------------------GPNLVI---------------------------------- R-------------------GSKLII---------------------------------- H-------------------GSNLIM---------------------------------- R-------------------GSHLII---------------------------------- N-------------------EHWMNM---------------------------------- K-------------------GHSLVY---------------------------------- --------------RAYGSIRQGSKYSTTYRQYL-KDGSVGSYFHDVPIGIQKDKCYVNM --------------RNYHNVLVGSKYSSSFKQYL-QNGEIGSYFHDVPLDLDVDAKTCNM --------------RQLSTTQQGSKYTLGFKKYL-KNGEVGSFFHDVPLDLNEREKTVNM --------------RHFSAVKQGSKYSRSFRQYL-QNGEIGSYFHDIPLELNHLNRTVNM --------------RQFSTIQQGSKYTLGFKKYL-TNGEVGSFFHDVPLDLNEHEKTVNM --------------RQFRTIQQGSEYTIGFKKYV-INGEVGSFFHDIPLDLNEREKTVNM ------------------------------------------------------------ --------------KQFSTIQQGSKYTLGFKKYV-TNGEIGSFFHDVPLDLNEHEKTVNM --------------------------------------EIGSYFTNIPLELXFENSTVRM --------------HRYSTVVRGAKYSQDYAQYL-VNGETGSYFHDIPLGLDLEHREVNM --------------RSFGSVIQGSKYTPEYTQYL-KNGEIGSYFHDVPLGLSQKDQTVNM --------------PDIIPINQGTKFTPDYTNYATTNGKIVSYFHDIALNLNKETREANM --------------PFYGKVVQGSKYTPEYAQYL-KNGEVGSYFHDIPLDLNRDECTVNM --------------SSISNVDQGTKYTTDFKNYAVNNGQILSYFHDVPLDFDIETKTANI --------------PDIIPINQGTKYTADYANYA-TNGKIVSYFHDIALNLNKDTREANM --------------PLVIATNQGTKYTATYANYATTSGKIISYFHDIDLGLDLVAKEANF --------------PDIIPYNQGTKYTPDYANYA-THGKVVSYFHDIALDLNKETKEANI --------------SQYASAQVGSRFSSSYKNYAVQENKIVSYFHDIPLSLDVEKRTVNM --------------KDVSSVSRGSKYTTEYKNYA--DGQVISWFHDVPLNLDIEAAEANI --------------PTIVSVDVGSKYSATYRKYA-ATGKILSYFHDVPLGFDASKKTANM --------------RNFHSASVGTKYTSDYKKYL-KNGEIGSYFHDVPLNLNESEGTVQM ------------------------------------------------------------ VVEVPRWSSGKFEISKELKLNPITQDVKKGKVRFVNNIFPYHGYIHNYGAIPQTWENVTS IVEVPRWSNGKFEISKTEPFNPITQDIKKGKPRFVNNIFPYHGYIHNYGAIPQTWEQPLI IVEVPRWTTGKFEISKELKFNPIIQDTKNGKLRFVNNIFPYHGYIHNYGAIPQTWEDPTI VVEIPRFSNGKFEISKEIPFNPISQDVKKGKVRFVNNIFPFRGYIHNYGAIPQTWEDPTS IVEVPRWTTGKFEISKELRFNPIVQDTKNGKLRFVNNIFPYHGYIHNYGAIPQTWEDPTI IVEVPRWTTGKFEISKELRFNPIIQDTKNGKLRFVNNIFPYHGYIHNYGAIPQTWEDPTM ------------------------------------------------------------ IVEVPRWTTGKFEISKELRFNPIVQDTKNGKLRFVNNIFPYHGYIHNYGAIPQTWEDPTI XVEVPRWSNGKFEISKEIEFNPIVQDVKKGKVRFVNNIFPYHGYIHNYGAIPQTWEDPTR VVEVPRWSNGKFEISRTEDFNPIKQDVKNGKPRFVNNIYPFKGYIHNYGAIPQTWENPAA VVEVPRWSNGKFEISTKKSFNPITQDMKKGKVRFVNNIFPFHGYIHNYGAIPQTWEDPTV VVEIPRWTNAKFEINTKTPGNPIVQDIKKGRVRFVKNLFPHHGYIHNYGAFPQTWEDPTT VVEVSRWSNAKFEISRERMFNPIVQDQKNGKVRFVDNIFPSHGFIHNYGAIPQTWEDPTI VVEIPRWSNGKFEINTELPGNPITQDVKKGKVRFVKNLFPYHGYIHNYGAFPQTWEDPNT VVEIPRWTNAKFEINTKTAGNPIVQDIKNGKVRFVKNLFPHHGYIHNYGAFPQTWEDPTT VCEIPRWSNAKFEILRNAPGNPIVQDSKNGKVRFVKNLFPHHGYIHNYGAFPQTWEDPTE VIEIPRWTNAKFEINTKLAGNPIVQDTKNGKVRFVKNLFPHHGYIHNYGAFPQTWEDPTT VVEVPRWSNAKFEISTSLEGNPIVQDTKNGKVRFVRNLFPYHGYIHNYGALSQTWEDPTV VVEIPRWSNAKFEIDTKLPGNPIVQDVKKGAVRFVKNLFPHHGYIHNYGALPQTWEDPTH VVEVPRWSNAKFEISTELDGNPIVQDVKNNVVRFVRNLFPYHGYIHNYGAFPQTWEDNTT VTEVTRWSNAKFEISKEDKYNPIVQDVKNGQVRFVKNLFPFKGYIHNYGAIPQTWEDSTE ------------------------------------------------------------ SLPKEPLFGDNDPLDCCDIGSTVLKMGDIKTVKVLGSLALVDDGELDWKIMVINTEDPMH E--LPGFKGDNDPLDCCEIGSSIAKMGDIKKVKLLGSLALIDDGELDWKVICIDIEDPIA EHEDLALRGDNDPLDCCEIGSDVLEIGSVRKVKVLGSLALIDDGELDWKIIVISVNDPLY SHQKHSLKGDNDPLDCCEIGSKVFAMGDIKTVKILGSLALIDDGELDWKVIVINVEDPLA EHKDVALKGDNDPLDCCEIGSDVLEMGSIKKVKVLGSLALIDDGELDWKVIVIDVNDPLS EHEDVALKGDNDPLDCCEIGSDVLKMGSIKKVKVLGSLALIDDGELDWKIIVIDVNDPLS ------------------------------------------------------------ EHKDVALKGDNDPLDCCEIGSDVLEMGSIKKVKVLGSLALIDDGELDWKVIVIDVNDPLS EIPFGSTRGDNDPLDCCEIGSSILQMGDVKDVKILGSLALIDDGELDWKVITIDSKDPLX E--LPGLNGDNDPLDCCEIGSAVFGTGEVRRVKVLGSLALIDDGELDWKVIVIDCEDPKS EHDIKGLKGDNDPLDCCEIGSAVLQMGDVKTVKVLGSLALIDDGELDWKIIVINVEDPLS KHH--GLFGDNDPLDVCEIGSKILSTGDVRRVKILGSIALIDDGELDWKVIVINVHDPLF EHAVTGLKGDNDPLDCCEIGTSVLSMGDVKRVKVLGSLALIDNGELDWKVLVIDVEDSLA KNEELGLYGDNDPLDVCEIGSNVCQIGDIKRVKILGSLALIDDGELDWKVIVIDTNDTLA KHH--GLFGDNDPLDVCEIGSKILSTGDVKRVKVLGSIALIDDGELDWKVIVINVNDPLF KHY--DLFGDNDPLDVCEIGSDILSTGDVKRVKILGSLALIDDGELDWKVIVVDIKDSLA KHH--GLFGDNDPVDVCEVGSRILSTGDIKRVKILGSLALIDDGELDWKVIVVNVDDPLA KSNVDGLVGDGDPLDVCEIGSRVWPTGSVRQVRVLGSLALVDDGELDWKVIAIDTEDPLA KDEALDLYGDNDPVDVCEIGSAILTTGLVKRVKILGSIALIDDGELDWKVIVIDVNDPLA KHKDTGLYGDNDPLDVCEIGSNVLEIGTVKRVKILGCLALIDDGELDWKVIVIDVEDELA FSKTESLKGDNDPLDCCEIGSELMETGQISTVKVLGSLALIDDGELDWKVIVINVNDTLA ------------------------------------------------------------ EKINNLADVEKYCPGLLDATRYWFKNYKVPTGKPVNEFAFNGEFQDYDKTMKTIEQCHQE IKLNKLADVDTVMPGLLDATRTWFRDYKIPAGKQPNVFAFEGEYQDQASTLSTVQECHEA HKLDNLENVEKHFPGILDATREWFRKYKVPMGKPLNKFAFREHYMDSDGAIKIIKECHNS SRVNTLQDVDIHFPGILGATKAWFRDYKIPAGKPSNKFAFDGQYKGVSDTIKIIESCHES SKIDDLEKIEEYFPGILDTTREWFRKYKVPAGKPLNSFAFHEQYQNSNKTIQTIKKCHNS PKINSLENVEKHFPGILNATREWFRKYKVPAGKPLNKFAFREQYKDSNNTIQIIKDCHDS ------------------------------------------------------------ SKIDDLEKVEEYLPGILDATREWFRKYKVPAGKPLNSFAFREQYQNSNSTIQTIKDCHNS DKLNDLXDVDTHMPGSLAATREWFRDYKIPTGKPPNEFAFNGQYKNAQETINTVQECHEA AELNTLDDVRRVFPRLLDDTITWFRNYKIPTGKPANKFAFDSEYQPVEKTLGVIQECHSS TQVNNLNDVRAHFPGMLEATRKWFRDYKIPAGKPANEFAFEGEYREISETLDVIAECHQS KEVNDINDLDEKCPGLLDTTRQWFRDYKLADGKPQNDFAFNGEYKNANETIDIIEQCHKS SKINNLTDIETHLPGLLQSTRNWFRDYKIPTGKPANEFAFNGQYRGISETLDVIQECHES QEIRDIHDVFVKCPGLLESTKQWFRDYKLPDGKPKNEFAFNGVYKNQQETIEIIKECNLS KNVNDIDDLDEKCPGLLDTTRQWFRDYKLADGKPQNDFAFNGEYKNASETIEIIEQCHKS SEVNDIDDLREKCPGLLEATKQWFKDYKLADEKPENKFAFEGKYKNANETLEIVQGCHDS KQVNDICDLDEKCPGLLDTTRQWFRDYKLADGKPQNEFAFNGEYKTADETIEIIQQCHES DELFDVHDVFVKCPGLLEATRQWFKDYKIPDGKPQNRFALGGKYRTSQETIETIVECQEA ENVNDIHHLYTRCPGLLETTRQWFRDYKLADGKPQNKFAYNGQYRNKKETLQLIQDCNKS PQLNSIEDVESVCPGLLEGTRQWFRDYKLADKKPHNKFAFNGRYLSAEEALEVVGECHSA PKLNNIRDVDIYFPGLLDSTRTWFRNYKIPDGKPANEFAFDGQYKDKDETIEIIKECYES ------------------------------------------------------------ WKGLVAGKSASPNILLPTTERKGTSISKDDR------LPDTPVPDHVNKWYYV---MGGI WNALVRGEADGSEAEIPSIVRAGTHIREPNQ------QNDTPIPQEVDKWYYV---MGGI WRKLVSGSQAKYDN-LPSIERAGKGVTQDSS------KPPSEIPPEVQKWYYV---MGGI WTNLVSGNVETNGVILPQIKKAGQGVFDDNL------EPDSPIPSEVDKWFYIKK-MGGI WKNLISGSQEKYDN-LPNTERAGNGVTEDSV------KPPSQIPPEVQKWYYV---MGGI WRKLISGSQNKYEN-LPNTERAGKGVTEDST------EPPSQIPPDVEKWHYV---MGGI ------------------------------------------------------------ WRRLISGSQDKYD-NLPITERAGNGVTEDSA------KPSSKIPTDVQKWYYV---MGGI WKRLISGN--ISGEKIPKIKRAGEGITASAE------EEQTPIPPEVAVWHYV---MGGI WKDLIDGKQYHK---LPNTTRAGKNVREEYK------LPDAQIPPAVDIWYHV---MGGI WKKLLKGDISE---KLPETKRAGGGVSEEKK------LPDSPIPSEVQRWYYI---MGGI WQQLINGEKTDKTPDITNTTVKGSPGFTDTINPSRAN---AAIPVDVEANYFIKTSPKGI WVKLLEASTDKR---LPQIKRAGSNIVEAKE------LADAPIPKEVGIWHFIRSNMVGI WQKLINGDTSGKIPKIENVSFASTPGHTEFDLLDNASKPPAKIPSEVDKIYFNGQDPRGI WQQLINGEKTDKTPNITNTTVKSLPGFTDTINPSRAN---AAIPVDVEANYFIKTSPKGI WKQLVLGNSEIKQIAITNTTLKETPGYEKFNVELNNPQPDAAFPVGTNRSYFFKPKPRGI WQQLINGQKSEKTPNITNTSIKESPGFSNIDTPAKTN---AVIPIDVEQNYFIKTDPRGI WKRLVNGEKPSGDFSTANVGVPDSEGHSRFSLGAVC-EPDTPIPAEVDQPFYVVT-PRGI WYKLITGQKGQKLPSIENATLVGTPGYGGYRLLVGKDETDAPIPVDIQRNHFIPTDPRGI WEKLIGGEKSKGDESLRNTTQKETPEYAPEFISPA--MPDTAIPPEISKSHFFPRS---- WKRLESGMKTQ---DTPLLDRAGSGVSEHEE------KEPARIPSSIDKWYYL---VGGI ------------------------------------------------------------ LKNAEEGDGAQEAQSLSRKQVYKNTQLNAQLTSKRDTPIDTRRGPPKDTLLMKREHDERL LKNAEEQSPNIESESISRKQVLKNTELNAKRTSSKIAHHGH--GIPKDVLSMKGEQDESL LKNPPEQLAQQDPETLERRQVYENTQKNAKLTSKRNVPGLGKRSLPKDIVSLKHEHDEQV LKNPRDQITKDETESLSRKQVLKNTQLNAKLTNANKKLQQQHGGPPKDTLTLKHEEEERL LKNPPEQLAQQDPETLERRQVYENTQKNAKLTSKRNIPGLDSTFLPKDTLSLKHEQDERV LKNPPEQLAQQDPETLERRQVYENTQKNAKLTSKRNVPGLGKGFLPKDTLSLKHEQDERV ------------------------------------------------------------ LKNPPEQLAQQDPETLERRQVYENTQKNAKLTSKRNIPGLGKTFLPKDTLSLKHEQDERV LKNPPEGQSSENEESVSRKQVYKNTQLNAKSTSSEASGAAPISNLPKDTLSSKHLQDEAL LKNPEQETHNAEPESVTRQQVLKNTRLNAQMTTRSSDLHNGAHGVPKDTLQLKRMHDERL LKNPEQEGPAAEPESITRKQVYKNTQLNAQLTSKSGQDSDVKHGIPKDSLSLKQEHDERL LRNKPEGYVEETPDKLDRNEVIKNTRLNAQLASESSKGDEIRAKIAEKKKEQGNSAEEHL LKNPSQNGDSEEPESISRKQVYKNTQLNAQLTSNQSNGKDSKSGIPKDTLSLKHEHDERL LRNKVSESAESNADRLDRQEVIKNTRLNAQLASESSKGDKIRAKIAEAKSHQRDDGNDHL LRNKPEGYVEETPDKLDRKEVIKNTRLNAQLASESSKGDEIRAKIAEKKKEQGHSAEEHL LRNKSQHSPQCHPDKLDRQEVIKNTRLNAQLKSESARGDAIRAKIAEEKRKQGDPDDEHL LRNRPEEYHEETSDKLDRNEVIKNTRLNAQLASNSTAGDEIRAKIAAKKKEQNNT-DEHL LRNKGQHSPHETTQELDRQEVIRNTRYNAHLKSESAQGDKIRAQLAEAK----HDEKDHL LRNKPESTSAIEID---RQEVIKNTRLNAELTHASLEGDKIRAELAKKHL---QDGNEHL ------------------------------------------------------------ LKNPKEQVTKEDTEDVARKQVLKNTQLNAKLTSLDSKMHMSSHILPKDTLTLKHEHDEKL ------------------------------------------------------------ QWNQKNLDENEKQQFQDIHVDEPKTPYQGAVDPEGEYYKVDDDELDDFSLGEPEYKVSAT KWNKKNLEENEKQEFGDIHIDEPKTPYQGAVDPNGEYYKIDDDDLGGFSLGEPQVDLKED QWNQMNLAENEKQQFQDIHIDEPKTPYQGAVDPHGEYYKVDDDEIDDLSLGEPEFQIKEN QWNQKNLSENEKQQFADIHIDEPKTPYQGAVDPNGEYYHVDEEDLENFTLGEPEFNMEET QWNQRNLAENEKKQFQDIHIDEPKTPYQGAVDPHGEYYRVDDDEIDDLSLGEPEFEIKEN QWNQRNLAENEKQQFQDIHIDEPKTPYQGAVDPHGEYYRVDDDEIDDLSLGEPEFEIKEN ------------------------------------------------------------ QWNQRNLAENEKKQFQDIHIDEPKTPYQGAVDPHGEYYRVDDDEIDDLSLGEPEFEIKEN KWNQKNSDANEKQQFQDI------------------------------------------ QWNQQNLDQNEKQQFQDIHVDEPKTPYQGAIDPEGEYYKHDDDDLENFTLGDPEYSVPVP KWNQRNLAENEKQQFQDIHVDEPKTPYQGAVDPSGEYYREDDEELDNFSLGEPEFKPSEN KWDEINLYKNEQEKTATMKIDEPKTPYEGGFNPEGEYYRDDDDNIPAFELGEGEFDIKDT KWNQKNLDENDKQQFQDINIDEPKTPYQGAVDPSGEYYREDDEELESLSLGEPVVEMQSS QWDEVNLYKTEQEKCATMKIDEPKTPYEGGFNPEGEYYKDDEDEIPDFELGSGEYDIKDP KWDEINLYKNEQEKSATMKIDEPKTPYEGGFNPEGEYYREDDDNIPAFELGEGEFDIKDT KWDEVNIYKNEQEKSATMKIDEPKTPYEGGFNPEGEYYKDDDNEIPEFELGEGEYDIKDE KWDEINLYKNEQEKSATMKIDEPKTPYEGGFNPEGEYYRDDNEEIPAFELGEGEFDIKDE KWDEINLYKTEMEKAATMKIDEPKTPYEGGFNPEGEYYQEDDETIPDFTLGESQPQVKDE QWDELNLYKTEQEKSSTMKIDEPKTPYEGGFNPQGEYYQNDDEYIPEFELGEGEFDIRDP ------------------------------------------------------------ QWNQKNLEDNEKLQYKDIHVDEPKTPYQGAVDPNGEYYKIDDENLDDFSLGEAEYDTKPT ------------------------------------------------------------ ADNDDESDAEPEELTPEEKHRRFEEMRKKHYNVKEVFRNKQALDDEMFEVAVGSALRRAL KEPVSPPVLETEEDEAAKKHRKFEEMRKKHYNVKADLQNAKQNPDDMFDITIDEGLRQRL KQPDIETNDENDEDSSEARHKKFEELRKKHYDVRAIFNGKPHEEDEMFDIKLNRQTTEFL DNKSIVENNDENSDEEAAKHRRFEEMRKKHYDLKEVFKNRRIHVDEMFDIKLNVPLKEAL KQPDFETNDENDEDSPEARHKKFEEMRKKHYDVRAIFNKKSREEDEMFEIKLNDRITEFL KQPDIETNDENNEDSTEARHKKFEEMRKKHYDVRAIFNKKAHQEDEMFEIKLNDKITDFL ----------------------------------------------MFEIKLNDKITEFL KQPDIETNDENDEDSPEARHKRFEEMRKKHYDVRAIFNKKSREEDDMFEIKLNDRITEFL ----------------------------------------------YVQIKLNDQLKRHI PVANGEPEGSQEADDDQAQRRRFEELRRKHYNVREAFSNRQLSEDE-------------- KEEALDEEHDEEDDDKEARHRRFEQMRKEHYNIKEALKNRKLYDNDMFEIQLNDELKELL NQQDKEEDSGERELTAEEKHKRFEEMRKQHYHMKALPLKQKIEPDEMTSFELTPTLKETI SNNSDSEGPSNEEESKEARHKRFEELRKKHYNVREALHSRPENVDDMFEIKLNSKLTSQL RYEEEESKENEEPAETTEKHKRFEEMRKEHYHLKGNALKQKIESDEMTKFEITPALRDII NHQDEEDDSGEKELTAEEKHRRFEEMRKQHYHMKGLPLRQKIEPDE-------------- SQNDAEEEQDQEPLSAEERHRRFEEKRKEHYHLKALPLKHKIDPDEMTLFEITVQLKTLI NQPAEEEQEEEEEEDKEEPQLSFEEKRKRHYHLKALPLKTHDTVD-MTQFEITLKLKETI EQEPEEEEEEEQPLSAEERHRRFEEMRKKHYHHAAAPLKHSVDDDEMTQYELTQTLWNLI SYDDVEEEEEEEPELTAERHKRFEEMRKAHYHMKGNVMHRKLEDDEMTRYTLTPKLEQLI ----------------------------------------------MVLFTISSALREHI LDEVSEQAEQLEEDDKEARHKKFEEMRKKHYNVKEIFKNKHLHEDEMFEIKLNENISKFL ------------------------------------------------------------ ESAVEDAKVRLLIERGSVPCGELAELCRAWGSEVSVSEALSGLEFKFKDRETRKP--SPE EKLKEDHRASLSLQQNSISFELLSELYQQFWRDVSMKQLLKSGKLRYKEKRVPGEGYSES RKFKSDEDIEVFLQGNTVPINSLLFYVKEYTKECSMRELLTPLEFEFKPKVAKGSHYSED GELKERKEIDTLLNNGYIPMKTLLKYHSEYWKNIPMRQLLNPIEFQFKEKYQPGSTYSPE RKFKNDEDIDLFLKRHAIPMQSLLFYVKEYRKDCSIKELLKPLEFEFKPKAVRGLHYSED RNFKNDEDIDVFLERHAIPVRSLLFYLKEYDEDCSVRELLTPFEFEFKPKTVRGSHYSEG RKFKNDGDIDLFLQQHAIPMRSLLFYIEEYRKDYSIREMLRPFKFQFKPKNVRGSHYSED RKFKDDEDVDLFLQRHAIPIQSLLFYVKEYRKDCSMRELLRPLEFEFKPKTVRGSHYSED EELKKNKELDMILEKDCVSIEALIKMYEDHWQNVPLSQSLKPLNFQFKPKRIARSDYKPE ------------------------------------------------------------ NGIQPECRVEELLQNDSIPIKLLLEYHLEYWSERPISKLLSPLKFKFKEKYERGVNYSEE NASSLKDQKQKLLSNSHLTHADLIKFYQTCHPTSTLLQLIQQTKLYIPPYKTYIQPKTSE ALLADDGEAKAILDKGSISMKSLLSFCEKHWQDVAISELVTPLDFVYKTKRERGAHYSEE EKSEIAELANNLLSNAYISHENLVLFYKDFKPTPTLIALIKSTKHYTPNLNVKSTPKSKE ------------------------------------------------------------ EQLSLKREKQKLLSNKTISHGQLIEFYNECHPTPTLLALLKKSKLHIPPYKTFIKEKTPE SNSSLKDQKTKILSDSYIAHQDLVKFYQTCHPTSSLLQLIQQTKLHVPKFETHKQPKTKE KSSSLNEEIDRIGSKKSITHKELIRFYREHRPCSSLLELVRSTRMVIPNKNTETIPKTKE AASSLKEIKESVLSKTDISHVDLINFYKAFKPTDSLLELLKLTSLQIPNKNELDKPKSRE RTCGINEKFEHLMHTDHISDADLRTLYKKSSHD-TLLAFIRSTRLYIPNKNDDQHPKTKE NGLECKDELKKILANDSISMNSLLEFYKSKKSTITMSQLLCPLDFKYKEKRIPGSDYSEE ------------------------------------------------------------ FQAQLARLRALQQEQEYQQIVKNRDLAITTESEA--TPAQINREIKEQVTTVFNIIISVI FKAELENLKALQQEKEYQEMLKRDSLHLAGSTADEPSIAQINKEIKEQVSAVVNVLLTVF FKKNLEFLKYQEQELEYQTMVKRNKPISSLREEDELTPSQINKQIKEQVTTVFNVLVSVV FKKQLETLKLKQEELDYQNMIKNERKTLQIIKEETLTPAQMNKQIKEQVTTIFNIFVSVI FKKKLEFLKYQEQELEYQSMVKRSKSVFSLQEDDELTPSQINKQIKEQVTTVFNVLVSVI FKKSLEFLKYQQQELEYQGMVKRNGPASSLMEEDELTPSQINKQIKEQVTTVFNVLVSVV FKKNLEFLKYQQQEYEYQTIVKRNKPIYSLRDEDELTPSQINKQIKEQVTTVFNVLVSVV FKKNLEFLKYQQQELEYQSMVKRSKSVFSLQEEDELTPSQINKQIKEQVTTVFNVLVSVV FKEYLENLKLQQQEKDYQQLISANRELSTYEDEDPLTPAQINRELKEQVTTVFNILVSVV ------------------------------------------------------------ FKRQLEHLKLQQEENEYQEMIKRDGLGYLKENAEELTPSQMSKQIREQITTIFNILLSVV FIKTMEKLRLEAKEQEYRRLINPTPQYSTLYDKKDYTPQQASKELKNQLTTIINVFISVG FKLQLERLRLEQEESEYQNMVRRDGLAVGLQDSDNQTPAQITKQVKEQITTVFNILVSVV FIKSMEQLRLKNKEEEYQRLIRPKQEFNTLYDNGEITPAQAHKELKSQLTTIVNILISVG ------------------------------------------------------------ FLRQMERLRLEAKEKEYKQLINKSPEFATLYDNSEYSPAKAHKELKNQLTTIVNIAVSVG FLKSMERLRLEAKEQEYRKLINPTPQFSTLYEEKEYTPQQAAKELKNQLTTIVNIIISVA FLESMELLKLKAKEEEYRKLVGTSTDMNFVFTHDEENPSREIKQTRSHITTIFNIFISVG FVKSMEKLRLQEKENEYQRLVNPAPQYSTLYENSPDTPAMASKELKNQITTIVNILISVA FLASMEKLRLKAKEEEYQRLIRPSEQFTTLYDNHETTPAAASKELKNQVTTIVNVLISVG FRSQLEYLKTKQQEESYQEMLNKERIKIN-RDDDWVSPSQMNKQIKEQVTTIFNIIISVI ------------------------------------------------------------ SVVVAIWYWSRTSAGLAIHHRIFLCMFFGILVLVAEVVVYSSYLSKIEEAKASEKSKKEH GTIYAVWYVTRTGWDI--HVRVLLCLFSGLLVLTADVAMYNVYNRKIEEARTTERKKKVT SVVVAIWYWTGTSTNFPVHVRLLLCLFFGILVLVADVVVYNSYLRKLEEAKVKERTKVEK SVVFAIWYWTGTSAHMPVHYRLLLCIFTGILVLVAEVVVYNSYLTKIDLAKSQEKKKKEQ SVVVAIWYWTGSSTNFPVHVRLLLCLFFGILVLVADVVVYNSYLKKLEEAKVKEKTKVEK SVVVAIWYWTGTSTRFPVHVRLLLCLFFGILVLVADVVVYNSYLKKLEEAKVKERTKVEK SVVVAIWYWTGTSTNFPVHVRLLLCLFFGILVLVADVVVYNSYLKKLEEAKVKEKTKVEK SVVVAIWYWTGSSTNFPVHVRLLLCLFFGILVLVADVVVYNSYLKKLEEAKVKEKTKVEK SVAFAFWYWSGSSSGMALHYRVLISLFFGILILIAEVVVYNSYLQRVSDAKAKEKVKTER ------------------------------------------------------------ SVVWAIWYWSSSSTRIATHNRIFLCLFFGVLVLVAEIVVYNSYLKKIEEAKITERKKREK SVSYAIWYWTETSWGLPVSYRALLSVFFGLLVLVAEVVVYMGYINKIEDARDKERKKKEV SVVFAVWYWTGSSAGMRPQSRVLFCLFGGILVLVAEVVVYSSYLRKVEEARMKERSKKER SVVYAIWYWTDSSMKLQDGYRILLCLFFGILVLVAEVVVYMSYLNKIEEAKVKERNKLEV ------------------------------------------------------------ SVSYAIWYWTASSWGLKDSYRVLLTVFFGILVLVAEVVVYMGYLNKIEEARAKEKQKKEV SVAYAIWYWTETSWGLPLSYRVLLSVFFGILVLVAEVVVYMGYLNKIEDARTRERKKKEV SVVYAIWYWTDTSWKIKDSYRVLLCLFFGLLILVAEVVVYIGYLNKIEDARIKEKEKKEI SVAYAIWYWTESSWKLPDSYRILLCLFFALLVLVAEVVVYLGYLNKIEEARKTERSKKEV SVVYAVWYWTDSSMKMKDSWRVLLCLFSGVLVLVAEVVVYMGYLNRIEEAKIRERKKKEV SVVTAIWYWTNSSMNISAEYRILLCLFFGLLVLVAEVVVYSSYLRKIEEAKNLERSKFEN ------------------------------------------------------------ KKLVQKYV-MSGRRGKIINPRTRGAVRNVGFRNLISDPFAISSILIGLISWVITLGGCIS RKVVKRLVALIKASQARAVRENPHVSHQFNISSFLGDPFAIGTLSIALISWIIALAGSIA KKVLEKIT--------------MATDHSFNMKNFYADPFAISSISLAIVSWVIAIAGSIS KKVLKKIVAIPDRAQAKAQRTRNKIIHTFDIKNLLGDPFAISTLSIALISWVITIAGSIS KKVLSKITISSKIRPTPRKPSRMATDHSFKMKKFYADPFAISSISLAIVSWVIAIGGSIS KKILEKITLSSKVRPTPRKPTRMAGDHSFKMKNFYADPFAISSISLAIVSWVIAIAGSIS KKVLTKITLSSKIRPTPRKTPRMATDHSFKVKNFYADPFAISSISLAIVSWVIAIGGSIS KKVLSKITLSSKIRPTPRKTSRMATDHSFKVKNFYADPFAISSISLAIVSWVIAIGGSIS TKVVKRIV--------------HLHSLRFQLHFCHG---------------VLPLSXCXA --------MTLRATKARQQRVSPHIGHTFSFGNLVGDPFAISTLSISTIAWLITLGGGIA KTVVQKIV---------------------------------------------------- KKVVRSIN------------------MGFSLSNFTSDPFAISTVSFGIMAWVVAIAGAAS KTVIKTLTAVPNRTEAKQMRSSPHRLHEFKAANLFTDPFAISSLSLALISWIIAFAGSVA KKLVRTLE------------------MSFSISNFIGDPFAISTLSFGLIAWIISIAGAGA --------------------------MGFSLLNFTGDPFAISTVSFGIMSWVVAIAGAAS KKVVQTFD------------------MGFKIRNFTGDPFAIATVSFGLIAWIVALAGAAA KKVVRTFN------------------MGFSLSNFTGDPFAITTISFGIISWVVALAGAAA KKVVRSIT------------------MGFRMANFLGDPFAISTVSFGVIAWIVAIAGAGS KKVIRTVE---------------------------------------------------- KKVVGVI-------------------MAIRLSNFIGDPFAIATVSFGLIAWIVAIAGAGS RQIVKTIKMIPSRANAKARRAGHHVRHSFGISNLVGDPFAISTISISMISWVITLGGSIA ------------------MRQPFSYRPQFQLGLLMGDPFALSTISLGIIGWIIALGGSIG VQVNE-DFPRFTWWGIAFQFLIILMLIGFYIYDLVDYYRNFLTASIGVAFVYSTNSANYL VAASTSPFPRFSWWTIVYEILLMITLFIVYCLDLVDYYRMFITCAVGIAFVYTSNSTNSI SASTNESFPRFTWWGIVYQFLVICSLILFYCFDLVDHYKIFLTTSIAVAFVYNTNSATNL SVTDDETFPRFTWWGIAYQFLLICMLIIFYSYDLIDFYKGFLTGAIAVAFVYTTNSATNL SASTNESFPRFTWWGIVYQFLIICSLMLFYCFDLVDHYRIFITTSIAVAFVYNTNSATNL SASSSESFPRFTWWGIVYQFLIICSLVLFYCFDLIDHYRIFLTTSIAVAFVYNTNSATNL SASTNESFPRFTWWGIVYQFLIICSLMLFYCFDLVDHYRIFITTSIAVAFVYNTNSATNL SASTNESFPRFTWWGIVYQFLIICSLMLFYCFDLVDHYRIFITTSIAVAFVYNTNSATNL TASDTDNFPRFTWWGIAYQFLILFMVIIFYCYDMVDYYKNFIAGATAVSFVYNTNSATIL TKKM----PHFSWWGIAFQFVMMVCFVVIYLWDLVDYYRGFLAAGVGVAFVYSTNSCSQL ------------------------------------------------------------ SKQE--NFPHFSWWGISYQIVIILIIFVLYANNNIELYKFTLVGLVSIAFIYTTNSTNNL AASDSKKYPSFSWWGIVYQLLLMVMILVFYCYDVIDYYKGFLCGALAVAFVYTTNSAAEM SNQD--KFPHFSWWGIMYQLVIMVVITVLYLYNTIELYKFTLVGLLSIAFVYSTNSTNHL SKQQ--TFPHFSWWGISYQIVIILIIFVLYANNNIELYKFTLVGLVSIAFIYTTNSTNNL SSQG--SFPHFTWWGIAYQIVIILVITVLYLNNNIELYKFTLVGLVSIGFIYTTNSTNNL SEQS--TFPHFSWWGVAYQIVIILIIFVLYANNNIELYKFTLVGLVSIAFIYTTNTTNNL SASD--NFPRFTWWGLVYEILLIIMVFLLYLNNTIELYKFTLVGLLSVGFLYTTNSTNNL ------------------------------------------------------------ SPQS--HFPRFTWWGIVYELLIILLITFLYLTNTIELYKFTLVGLIAVAFVYTTNSANGL SATDRESFPRFTWWGIAYQALLLFIMIVIYCYDLVDYYKGFISSGSGVAFIYNTNSATNL ASDQ---FKNFGWWGLAFEFFVILCVFLVVATDSVEPYRQMLLAFLALATMYVTNSTNNV IYGSGNQKAAASAGVVLLSMVNLIWIFYYGGDNASPINRWVDSFSLNGIRPSPFEAAKIK VYYEGSKSGAAAAGFILLSMINLVWVIYFGGDNASPTNRWIDSFSLRGIRPSVLETSMAI VYADGSKKAAASAGIILLSIINLIWILYYGGDNASPTNRWIDSFSIKGIRPSPLENSLHR VYAEGSRKAAASAGVILLSIVNIIWIFYFGGDNAAPTNRWIDSFSLKGIKPSPYQSLLLR VYADGPKKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFSIKGIRPSPLENSLHR VYADGSNKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFAVKGIRPSPLENSLHR VYADGPKKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFSIKGVRPSALENSLHR VYADGPKKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFSIKGIRPSPLENSLHR VYGDGSRKAAASAGVILLSIVNLIWIFYYGSDNASPTSRWIDSFSSRGIRPSADA----- IYQEEPQQAAGSAGFMMLSIVNMIWMFYFGADNAAPANRWIDSFSIRGIRASQ------- ------------------------------------------------------------ IYNSNSAGLCCAAGCILLSILNLIWILYFGGHPESPTNQFIDSFSLRGQGHEQLGPQMGN LFRDGSRMGAASAGVILLSMVNIIWLFYYGADNASPSNRWIDSYSLRGIRHSVLESTIAA IYKTGDSGLCCAAGCILLSMLNLIWILYFGGHPESPTNQFIDSFSLKTHSHNHLP-SADN IYNSNSPGLCCAAGCILLSILNLIWILYFGGHPESPTNQFIDSFSIRGQGHEQSGGQMGN VYNSSSSGLCCAAGCILLSILNLIWILYFGGHPESPTNQFIDSFSSNKYANEYRSSVLKT IYNSDSSGLCCAAGCILLSILNLIWILYFGGHPESPTNQFIDSFSIKNHGHEHLGNQDYR IYSSNSGNLCCAAGCILLSMLNFLWIVYFGGHPESPSNQFIDSFAMKSSYAQQ------- ------------------------------------------------------------ VYESNSGKLCCAAGCILLSMLNLIWIVYFGGHPESPTNQFIDSFSIKSHTHNHLS----- VYSNGARKAAASAGVILLSVINLIWVFYYGGDNASPTNRWIDSFSLRGIRPSAYEDALIR VYNGTSASSASGAGHILLSIINFLWMIYFGTTHEAGIHAWVDSFAADKGHS--YN----- AYRRGSSVKLTHSTNNLHSASENLGLDNGFYNNP----HTSNYVSSTALTEFENTGPPYP ARSLPVKPSYPYSASLPDVHHDDEGEGHSGNMYAPELQSSTKYVSSTVLNGFENTDHSSS ARRRGNRITTPYQNNVYNDPARDSGYATHFDGYPQQQPSHSHYVSSTALAGFENTQPSDA SARRSMNNNNNHSNRIYSDNMDYNNNNIGSQRMAATNSEPQHYVSSTALTGFENTDPSHF ARRRGNRNTTPYQNNVYNDAIRDSGYATQFDGYPQQQPSHTNYVSSTALAGFENTQPSEA ARRRGNRNTTPYQNNVYNDNMRDSGYATQYDGYTQQ--QHSNYVSSTALAGFENTQPSDA ARRRGNRNTTPYQNNVYNDPVRDSGYATQFDGYPQQQPSHSHYVSSTALAGFENTQPSDA ARRRGNRNTTPYQNNFYNDAMRDSVYATQFDGYPQQQPSHSNYVSSTALAGFENTQPSDA ---SMRARRRNRNNLRSQRFTGDNFYPEH---------QPQNYMSSMALTGFENPDP-AY ---VESSLALARSQKAVASP-----QPAATAFYGGLEGHSQKYVSSTALNGFENTDP-HT ------------------------------------------------------------ GPFTGAIINPNLQQPLSDSIGGSAHHTPINVNNN----NNTGYMTSSHLTGLENFSS-PH NARLLSRNVSKYSASAHEGFYNDPVPPQTTGFYP--DSHSQHYVSSTALNGFENAGP-PM KAAEYKRYSSSQGNTQFQDNNLRQSQLTTNNK------SNTPYMSSSQLNGLENFSSSDV GPFLQQPLTGSFGGSTNHTPTNANTNTNTTTTNNNN--NNTGYMTSSHLTGLENFSS-PN EPFAASKRFTSTGISLPQENVSQMSQTNTHSQQQQHSTNATSYFPLTQLHGLENSSQ--- RYVPQGPLRLGSHQDISSGNGNTTMQPPNMPGSAVHTPNNNTYMSSSHLAGLENFSS-QD ---LPSEKNDDHEFAVPRSASGSQGFGVSDSRHSQLT-NKSGYMSSSQLNGLENFSHTNV ------------------------------------------------------------ ------------SDEKHDDDLRVAPAPEAFQDNNLRQSQKTPYMSSSQLNGLENFSSADV ---SLRRRSAVHSRNLQNAALERENLHLSTNLYNGVD-QNQNYVSAVGLTGFENTNPNST ---NDQFAMRRSNP-----FSLHDQQRQSLGVPG----RPVSAYS-AGMGGVANYNGLQL SASDLPTNNNAPLRSPQLGNNTIGDTYITATTNNNTNTTMGDTMGLYADLADESFPYRVK KPNLDVNAQNTATLNTQA-----TGTFITDTTNANTDTTMGDTLGLYSDIGEESFPYTAE VNVHLNTLQQRINSTSNANDNSNGHTFDTDFSNGNTETTMGDTLGLYSDIGDDNFVYKAK NSNSNIAGTRQTDSNINSNNLNEVSTFMTETSNGYTATSMGDTLGLYNDLEDENFTYTVK VNLHLNTLQQRINSASNANDNSNGNTFDTDFSNGNTETTMGDTLGLYSDIGDDNFIYKAK VNVHLNTLQQRINSAGNANNNNNGNTFDTDFSNGNTETTMGDTLGLYSDIGDDNFTYKAK VNLHLNTLQHHINSASNAGNNANGNTFDTDFSNGNTETTMGDTLGLYSDIGDDNFIYKAK VNLHLNTLQQRINSASNAINNNNGNTFDTDFSNGNTETTMGDTLGLYSDIGDDNFVYKAK YTGPNVPLDRNGSVA--------------------------------------------- STAFALGPEGPTQRNLDTHGTST---YVTDTTNGNTETTMGDTLGLYSDMGDENFPYTAK ------------------------------------------------------------ VPGSGTGAGLGVGAGRDLTHNSNGSGGGPASANNSNNTNKRNTIYTDSETGTGTFRYKAK APALHGGNADTLHNTNTF---------VTDTTNGNTETTMGDTLGLYSDAGDESFPYLAK HQSRDLTSNKRQTV----------------YNDTNSVNDTGN-----------VFRYKAK VPNNGIGLTRDLTHNSNSLNNNS-HNGATGSINNSNNTNKRNTIYTDSETGTGTFRYKAK --------DMMGSAPRDL----------TQNTNTNSSGTKRNTLYTDSEGGTGTFRYKAK VPG--SGATGRDLTNNSTSNKRN-----TIYTDSETGTGI-------------TFRYKAK QNTGTVGASNPASMPNTV------------YNTNGTNTADSNFAVPVS-----TFRYKAR ------------------------------------------------------------ RQSRDLTNSRRQTVIADE----------------------EDAP---------VFRYKAR NSNFNSPYRDQQNDEVISRNPTDVNTFVTESSNGNTETTMGDTLGLYSEFGDESFPYTAR GGFENSSNAEPHQASPAF--------SQQQQQQTATPQQATDSLFVAT-----EYPYRAR ALYSYEADSADAYEMSFEQGEILMVSDIEGRWWKAKKESGETGIIPSNYVTIIDNDTEQR ALYTYQADQTDAYEISFEQGEILRVGDIEGRWWKAKKSNGETGIIPSNYVKLLDGKSHLQ ALYPYDADGDDAYEISFEQNEILQVSDIEGRWWKARRANGETGIIPSNYVQLIDSPEEMQ ALYSYKADDSDAYELSFEQGDILKVSDIEGRWWKARKENGQTGIIPSNYVKLMD----IR ALYPYDADDDDAYEISFEQNEILQVSDIEGRWWKARRANGETGIIPSNYVQLIDGPEEMQ ALYPYDADDDDAYEISFEQNEILQVSDIEGRWWKARKANGETGIIPSNYVQLIDSPEE-- ALYPYDADDEDAYEISFEQNEILQVSDIEGRWWKARRANGETGIIPSNYVQLIDGPEEMQ ALYPYDADDDDAYEISFEQNEILQVSDIEGRWWKARRANGETGIIPSNYVQLIDGPEEMQ --YSXXXTP--------------------GAXTQDMNANNQNNLNPNN------------ ALYAYEADASDAYEISFQQGEILRVGDIEGRWWKAKKANGETGIIPSNYVELVDDPAALR ----------------------------------------------------------IQ ALYSYDANPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLDT---TR ALYTYTADSNDAYEVSFEQGETLRVGDIEGRWWKAKRANGETGIIPSNYVELIDENSILQ ALYSYDANPEDINEISFAKDELLEVDDIDGKWWQAKRSNGQVGICPSNYVKLMD------ ALYSYDANPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLDT---SR ALYSYDANPDDINEISFIKDEILDVDDVDGKWWQARRANGQVGICPSNYVKLIDT---IQ ALYSYDANPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLDT---SR ALYSYDASPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLD----MN ----------------------------------------------------------IR ALYSYSANPEDINEISFTKDEILDVDDIDGKWWQARRATGEVGICPSNYVKLIE----SR ALYSYQADDADGYEVSFEQGEILKVSDIEGRWWKSKKETGEVGIIPSNYVQLIEDDEGIR AVYAYQANPEDANEISFDKGEILDVSDISGRWWQARRDNGEIGICPSNYVELLA----LT SIRISSAALYLVLTLVSIPISFKIGGLQCGLSFTVTLFNLYLISTTLSVLARRSTSILYY TLRIFLTTMYLFLVLITIPISFQVGGLNCGLSFTVTLFALYFVSTTFKLVLLDRSTLIYY SGRICAACFYLLFTLLSIPISFKVGGLECGLSFTVTLFTLYFITTTLNVLARRNTSCLYY GIRICSATFYLLFTLISIPISFKIGGLHCGLAFTVSLFILYFLSTTLSIWARKYTNILYY SGRICAACFYLLFTLLSIPISFKVGGLECGLSFTVTLFTLYFITTTLNVLARRHTNCLYY ------------------------------------------------------------ SGRICAACFYLLFTLLSIPISFKVGGLECGLSFTVTLFTLYFITTTLNVLARRYTSCLYY SGRICAACFYLLFTLLSIPISFKVGGLECGLSFTVTLFTLYFITTTLNVLARRHTSCLYY ------------------------------------------------------------ SLRFALASFYLFLVLITVPISFQIGGLYCGLSFTVTLFILYFVTTTLKITAATRASTLYY SIRGCLTTFYLLLVLITIPISFQVGGLYCGLSFTVTLFNLYFLTTTLKIVSKKYTSFVYY SIRAILATLYLVLIILTIPLAFDVGGVNCGLAYSLTTLVTYFILTTIRILVRKTISIIYY SIRVCLTSFYLLLILITIPIAFQVGGLYCGLSFTVTLFNLYLITTTLKIAAR--ASAAYY ------------------------------------------------------------ SIRAILATLYLVLIILTIPLAFDVGGVNCGLAYSLTTLVIYFILTTIRILTHKSISMIYY SISALFASLYLALIILTIPLAFDVGGVTCGLAFSFTTLVIYFVLTTIRILSRRTISIVYY SVRGIFSTVYLGLIILTIPLAFDVGGVYCGLAFSLTTLVTYFILTTIRIAVRRTISIIYY ILPPLLSAYYLALVVLTIPLAFDVGGIECGLAYSLAMSALYFVLTTLRLASRRSATVFYY SVRAFLGTLYLVLVILTIPLAFDVGGVTCGLAFSLTTFLLYFLLMTIRLVTRRSISILYY ALQALFSFAYLALVILTVPLAFDVGGIPCGLSYSFTLFSIYFVLTTVRMITKKSVSLLYY SVQVVLVCFYLLNIVTTIPISFKIGGLYCGLTFTVTLFYLYFTSTTLNIIARRWTSSFFY LFRAAYSLIHLTLVMITIPLSFDIGGRFCGLAFSFTLVVSYFILSTFRILSGRTAQILYY SQHLVIAPLLFLFLSGFSNEEFNRKFIVQPWQWLLSYSTPFFTLLEGFFTILAIQAIGET LQHLLIPSILFMFLSYFENIDSDTNVMVKPWQLSLIHSTPVFTLLEGVFTILAIQAIGET SQHFVIASLLFLFLSGFSNDELGNRFVVQPWQFILTKSTPFFTLSEGFFTILAIQAVGET FQHFIIASLLYLFLSGFSNEQLSSRFFVQPWQFILSYSTPFFTLSEGFFTILAIQAIGET SQHFIIASLLYLFLSGFSNDELGNRFVVQPWQFVLTKSTPFFTLSEGFFTILAIQAVGET ------------------------------------------------------------ SQHFIIASLLYLFLSGFSNDELGNRFVVQPWQFILTKSTPFFTLSEGFFTILAIQAVGET SQHFIIASLLYLFLSGFSNDELGNRFVVQPWQFVLTKSTPFFTLSEGFFTILAIQAVGET ------------------------------------------------------------ LQHFLMPSILFLFLSGFNNDQLQKRYVVRPWQYMLLHATPCFTLTEGFFTVLAIQVIGET LQHFIIPSLLFLFLSGFNNDELKRKFTVKPWQFVLLHSTPYFTLLEGFFTVLGIQAIGET CQHFFIPSLLTYFLSYYSHENIKKFNPVMIWRLVLINSTPIFTVLEGFCSLLLIQAMGQT AQHFFIPSLLFLFLSGFSNDELKHHYVVRPWQFLLLRSTPYFTLLEGFFTVLGIQAVGET ------------------------------------------------------------ CQHFFIPSLLTYFLSYYSHSHNHNFNPIMIWRLVLINSTPIFTILEGFCSLLLIQAMGQT SQHFFIPSLLTYFLSYYRQNHQIE--LLSVWKTLLVNATPVFTILEGFCSLLLIQAIGQT CQHFFIPSLLTYFLSYYSN-----YNPIMIWKLILINSTPLFTILEGFCSLLLIQAVGQT SQHVLMPSLLMHFLQRYPRSGALP--ALAVWRYLLVHSTSVFTVAEGFCSLLLIQAASQT SQHFVIPSLLTFFLSYYRTE----INPVDIWRFLLINATPVFTILEGFCSLLLIQAIGQT TQHFVIPSLLTFFLSYYSTKQPSP--PVDVWKFCVVNSTPIITIMEGFCSLLLIQAVGQT FQNFIIPSLLHLFLNGFANEDLIKSYTVKPWQVILSYSTPVFTLLEGFFTILGIQTIGEM LHTILIPALLIFYLSLNTANNNEPQRLVMPWDALMQSSAPFFNILEGFCTLLFIQTIGQV NKWLSYENSNTWIITSLLVSGGVITGSLYYLYRIYVTPKLTIQSASLLGFVLSIVFCLGL ERWLKMSRSNQWVILSLLISGGIITLSLFYFYRIYVTPELSTPSASLLGFTFSIVCGIGL NRWLSNDNSNTWIISSLLASGGVITASLYYLYRIYVTPPLSIQTASLLGFVLSMVCGLGL NKWLVYENSNTWVISSLLASGGVITASLYYLYRIYVTPQLSVQTASLLGFTLSLVGGLGI NRWLSNDNSNTWIISSLLTSGGVITASLYYLYRIYVTPPLSIQTASLLGLVLSMVCGLGL -----------------------------------------------------MVCGLGL NRWLSNDNSNTWIISSLLASGGVITASLYYLYRIYVTPPLSIQTASLLGFVLSMVCGLGL NRWLSNDNSNTWIISSLLASGGVITASLYYLYRIYVTPPLSIQTASLLGFVLSMVCGLGL ------------------------------------------------------------ GRWLRYKNSTAWVISSLMVSGVVITTSMYYLYRIYVTPPLSVHTATLLGFTLSLVFGLGL NKWLRYHNSNTWIIVSLLISGGVITTSLYYLYRIYVTPELSIQTASLLGFTLSIVCGLGL MSWLTIYKSDSWLIISLIGSGSVITASFYFLYRIYVLPTIDMFSASLLGSILTTTMGLGL NRWLSRGGSNVWVISGLMTSGGVITAALYYLYRIYVTPELSVQTASLLGFTFSIVSGLGI ------------------------------------------------------------ MSWLTIYKSDSWLIISLIGSGSIITASFYFLYRIYVLPNIDMFSASLLGSILTTTMGLGL VNWLTNYKSDSWLIISLVSSALVDTAAFYFLYRIYVFPTIDILSASLLGSLLTLTIGLGL VNWLTLYKSDSWLILSLIGSGSVITASFYFLYRIYVLPAIDMFSASLLGSLLTTTLGLGL LGWLTAHRSDSWLFVSLIGSGCTITGALYFLYRIYIFPALDLGNASLLGSFLTVTAGLGL INWLTIYKSDTWLIISLVGSGSTITAAFYFLYRIYVFPTIDIVSASLLGSLLTLTVGIGG LNWFTIHRSDNWLIVSLVGSGLTTTTACYFLYRIYTLNTIDMVNASLLGSSLTLTIGIGA NTWLKHENSNIWIISSLLTSGGLITGSLYYLYRIYATPNLSVGAATLLGFTLSLVGSLGI SKWLVHRKSDSWEIVLLISAGCVISATAYNLYRIYIATSVDLSTGTLAGMVLTLGFCLSS YGIISRKGSVIESSLFFAYIVRCIYEISPKLATRATEEDVWQTHQRNLLNILPDVTPVWK YGI-NGSGSVMESSLFFAYMVRNVYEISPKMAMNAMDEETWKIHQANLPKVPRILNPLWN YGIVSQRGSVIESSLFFAYIVRCIYEISPKLATTATDEDVWQKHQRNLPTIPRISKPFWR YGIVTDKGSVIESSVFFAYIVRCIYEISPKLATTATEEEVWQRHQANLTSKINIFMPIWK YGIVSQKGSVIESSLFFAYIVRCIYEISPKLATTATDEDVWQKHQRNLPTIPRISKPFWK YGIVSQKGSVIESSLFFAYIVRCIYEISPKLATTATDEDVWQKHQRNLPTIPRISRPFWK YGIVSQKGSVIESSLFFAYIVRCIYEISPKLATTATDEDVWQKHQRNLPTIPRISKPFWK YGIVSQKGSVIESSLFFAYIVRCIYEISPKLATTATDEDVWQKHQRNLPTIPRISKPFWK ------------------------------------------------------------ YGIISGKGSAIESSLFFAYMVHCIYEISPQLALTAMSENTWQMQQGTLPKLKKLVQQLWS YGIVSGKGSVIESSLFFAYIVRCIYEISPQLATSAMDEDTWQKHQGNLPTVQKRLQPLWK FGIISGKGSMIESSLLFAYIVKCIYETFPILSEAATKALTTQNLKKEIPKIPPILNPISE FGIVSGRGSTIESSLFFAYIVRCLYEISPQLATSAMDEDTWHNQHRSLRSLARRVQPLWK ------------------------------------------------------------ FGIISGKGSMIESSLLFAYIVKCIYETFPILSEAASKALTTQNLKKEIPKIPPILNPISE FGIVSGKGSMIESSLLFAYIVRCIYETFPILSEDASKALTTQNVRKEIPKIAPILNPISE FGIVSGKGSMIESSLLFAYIVKCIYETFPILSEGASQALTTQNLKKEIPKIPPILNPISE YGIVSGKGSMIESSLLFAYIVRCIYETFPSLSEDATQAQTTANLRLELAHLPRVADTLSA YGIVSGKGSMIESSLLFAYVVRCIYETFPILSEGATRTQATNNLRNEIPKLPHIINPISQ FGIVSGRGSMIESSLLLAYIVRCIYETFPDLSENASEAQTTTTLKNQIPLLPPIIDTVSN YGIVSHNGSVIESSLFFAYIVRCIYEIAPELATTATEEEVWQSHHANLNVTSRNFYPIWE YGVISRKGSSLESSLILAYTVYCLYFIFRKSSTSEPPVTIEYSSKQQYPPLPPIMDSYSA FFKNFTVSVPSSIVELVSVTYMASESLSPAVIVNLCFRILIFYSATRIIPALQRSSYKEQ SVKNFTKSVPISIQEIFVVTFMAKESLIPAVVINLVFRLLIFYSATRIIPTL-QRNTKER FCKNFTFSVPLSINEFCQVTIMASESVSPAIVINLCFRVLMFYSATRIIPALQRKNDKQL LLKTFTITVPSSINELCFVTYMACESISPAVIVNLCFRVLIFYSATRIIPALQRRDDNEL FFKNFTFSVPLSINEFCQVTIMASESVSPAIVINLCFRVLMFYSATRIIPALQRKNDKQL FFKNFTFSVPLSINEFCQVTIMASESVSPAIVINLCFRVLMFYSATRIIPALQRKNDKQL FFKNFTFSVPLSINEFCQVTIMASESVSPAIVVNLCFRVLMFYSATRIIPALQRKNDKQL FFKNFTFSVPLSINEFCQVTIMASESVSPAIVINLCFRVLMFYSATRIIPALQRKNDKQL ------------------------------------------------------------ FTKNFSAGIPRSIHEIFIVTLLARESINAAVVSNLVFRVIVFYSATRIIPALQRATGGTQ FTKNFTISVPSSIREIFRVTLMATESVTPTVVINLVFRILVFYSATRIIPALQKDNPNGR VIPFITSTLPSSFKGVWKFLIMAIKTLTLPLLLNLAYRIGVFYAATKIIPSLRQVSTTSL FVKHFTSSVPSSIQEIFLLTLMAREAIAPAVVINLCFRILIFYSATRIIPALQRKHKRR- ------------------------------------------------------------ VIPFITSTLPSSFKGVWKFLIMAIKTLTLPLLLNLAYRIGVFYAATKIIPSLRQPSSVSL LVPFLTSTMPSSFKGVWEFLVMAIQNLTLPLLLNLAYRIGVFYAATKIIPSLRHSSSTAL VVPFLASTLPSSFKGVWKFLIMAIQTLTLPLLLNLAYRIGVFYAATKIIPSLRQPSSVSL FLPSLAANLPHSFKAVWDVFFSAVHKLTLPLLVNLAYRIGVFYAATKIIPSLLGRDDKQS LIPFLASNLPGSFKTIWEFLLMAIQKLTLPLLLNLAYRIGVFYAATKIIPLLRQASNKSL AVPFLASNLPMTMKTIWHFLVISLQKLTIPLLLSLAYRLSVFYAATKIIPSLRQSSSSSL TLKTLTFSVPTSISELFHLTVMAIDSVSPAIIINLCFRLMIFYSATRIIPAIQKRTRSET LAKSFAAIVPSSFTAVFDFFYGAISTITPHVFVSLSFRIGVFYAATRIIPGIHYAGGFTF RQSRRILKLLYWYSPCVLIAMYTHLILQYSGEKRELCLWPRIVTDSWSFWNWCNIFWTVL RSFRRIMNFVYWYSPCIIIAMYTHLILRYSGQKNDLCIWPKIVVDSWSFWNWCNIYSTML RKSRRIMKGLYWYSPCILIAMYTHLILQYSGEKKDLCIWPEIIVDSWGFWNWCNIFCTIL RKSRRIMKVLYWYSPCILIAMYAHLILQYSGEKDELCLWPKIIVDSWGFWNWCNIFFTIL RKSRRIMKGLYWYSPCILIAMYTHLILQYSGEKKDLCIWPEIIVDSWGFWNWCNIFCTIL RKSRRIMRGLYWYSPCILIAMYTHLILQYSGEKKDLCIWPEIIVDSWGFWNWCNIFCTIL RKSRRIMKGLYWYSPCILIAMYTHLILQYSGEKKDLCIWPEIIVDSWGFWNWCNIFCTIL RKSRRIMKGLYWYSPCILIAMYTHLILQYSGEKKDLCIWPEIIVDSWGFWNWCNIFCTVL ------------------------------------------------------------ --SRKLMRIIYWYSPCIVIAMYTHMILRYSGENNELCIWDRWVVDAWGFWNWCNLFFTLL KSSRRLMRLIYWYSPCIVIAMYTHLILQYSGENNDLCLWSKVVVDAWGFWNWCNVFCTLA STPSVIIRLIYAYSPCLIIAVYTHLMLSYNGEGTELKLWIQLIVHPWQFWNWINMGTTLI --SRRFMRMLYWYSPCIVIAMYTHLIMQYSGQSNDLCLWSKVVVDSWGFWNWCNIFCTMA ------------------------------------------------------------ SSPSVIIRLIYAYSPCLIIAVYTHLMLSYNGEGTELKLWIQLIVHPWQFWNWINMGTTLI REPSAIIRLIYAYSPCLIIAVYTHLMLSYTGEGTELQIWSAIVVHPWKFWNWINMGTTLI SHPSVIIRLIYAYAPILIIAVYTHLMLSYNGEGTELQLWFQIIVHPWQFWNWINMGTTLI ENRPAVIRLLYAYSPCIVIAVYTHLMLSYRGEGSELMLWMVIVVHPWQFWNWINMGTTLL SEPSAIISLIYAYSPCIVIAVYTHLMLLYSGEGTELKIWVLIVVHPWQFWNWVNMATTIL FQKATILKLIYAYSPCFIIFAYTHLMMQYSGQGTELKLWFTVIVHPWQFWNWINMATTLL RKIRGIMKALYWYSPCILIAMYTHLILQYSGEKKDLCLWERINVDAWSFWNWCNIFWTII RYSYRRVFILYAYAPCVIIAVYTHLIMQNFDIPQNSGMW----AQGSQLWAWVGVLAFLA VYANELGTQAMSINSLQLLVPGSPSFEPHLTVVTHLQVQNRGDVSKVLQSCSSCLKTIPK IYALELGSNKMGIESLQTLFPNSPVFEPHVTVCSGLSCENMEEVHKVLEMAHHAINAVKS VYATELGSGSMAIFSFQTLFPNSPVFEPHITVTSHLVCNSRDDVNKILTSCAAAIQSIRS VYASELGTTPMSIQSLQTLFPDSPVFEPHVTVVTNLSAPNTDEVNKILMSCVAAMNSIKS VYATELGSGSMAIFSFQTLFPDSPVFEPHVTVTSHLVCNSKDDVNKILTSCVAAIQSIRS VYATELGSGSMAIFSFQTLFPDSPVFEPHVTITSHLVCNGRDDVNKILTSCVAAIQSIKS VYATELGSGSMAIFSFQTLFPDSPVIEPHVTVTSHLVCNSRDDVNKILTSCVAAIQSIRS VYATELGSGSMAIFSFQTLFPDSPVFEPHVTVTSHLVCNSKDDVNKILTSCVAAIQSIRS ------------------------------------------------------------ IYAVELGSR-MAILSLQTLFPDAVLFEPHVTITSQLRCDSADDAAAVLAAACAALRACRP IYGLELGGKSMAILSLQTLFPDAVLFEPHLTLTSQLNCNTTQDVETVLTSCVAAVQSIRA LYAAELSSNDMGMSSLNTLFPGPPKFEPHITITTNISLDTKDDVDRILSASAVAMNSLPK IYASELGSKSMGILSLQTLFPDAPSFEPHLTITSQLKCQSQDEVNKLLTSCVAALGAIKN ------------MSSLNTLFPGPPKFEPHITISSNIDVDTKSDVYRILSASLVAIDSLPK LYAAELLSND--MSSLNTLFPGPPKFEPHITITTNISLDTKDDVDRILSASAVAINSLPK LYVAELMSND-------------------------------------------------- LYAAELSSNDLGMGSLNTLFPGPPKFEPHITITTSIVMDTKDDVDRILSASAVALNSLPK LYMAELGSNDLGMNSLSTVFPGPPKFEPHVTITTNIALDPKDDVDRILSACCIALESLPR LYAAELGNDSMG--SLNTLFPGPPRFEPHITISTNVAVDTRKDVDKILSASAVALNSLPK LYTAEL-SGNLGNSSLNTLFPGAPRFEPHVTITTNIDIDTREEVDKILSASAVALRSLPQ IYGSELGGKKMGIHSLQTLIPNSPLFEPHITITSGLNITSQDDVNKILTYCVAAMDSVKP LYAVEL--SSLGIQGLKPIFSDSENFEPHITLTSNISVNTQGQVDFVLDRAVAAAKCVPQ GH-SLIKYSNWSINKQYFKKIVLECEKDKYLLSLAQLMRELYVEIEDQRRAEHWVIEEFQ KVDALVEFDGFNIGKKYFEKCRLECKPNPMLYSLAKLIRSMFVGE---LNIDTWLFEEFH HQTPLVSFNGCSIGKGYFKKIVLECNKNNILYGIAQIMREMYVEIDTESRAATWVHEEFQ SLIPLITFQKCSIGRTFFKKIILECQLNSYLISIAQIMREMFVESDQDEKASNWVRDEFK HQTPLVSFNGCSVGKQYFKKIVLECNKNKILYGVAQVMREMYVEIDPESRAATWVHEEFH HQSPLVSFNGCSVGKRYFKKIVLECSKNKILYGIAQIMREMYVEIDLESRAATWVHEEFH HQIPLVSFNGCSVGKRYFKKIVLECNKNKVLYGIAQIMREMYVEIDSESRAATWVHEEFH HQIPLVSFNGCSVGKQYFKKIVLECNKNKVLYGVAQVMREMYVEIDPESRAASWVHEEFH ------------------------------------------------------------ QLDPVVRFDAVAVGRRYFDKVHLACAHDRFLYGVAQVIRELFVQDPPDAAAADWVHSSFR KLKQLVSFTGVSIGKKYFDKVRLDCPKNRYLCSIAQVMRELYVASSAE-EASNWVLEEFH NHESLVKLGNVNSQRKFFKKLYFEVEKDPNLVSFARIIRELFVIVPQDYKAAEWSVQEFD NIKSIVSFSGVSIGKGYFTKVRLICNDNKYLMGVAQVIREVFVAENPE-DASQWLLQEFQ NHSNLVTLGKVDSQRKFFKKLYFQVARDPNLVSFATIIRELFVQLPADEQASLWSVTEFD NHESLVKLGKVNSQRKFFKKLYFEVEKDPNLVSFARIIRELFVIVPQDYKAAEWSAQEFD ------------------------------------------------------------ NHESLVKLGNVNSQRKFFKKLYFEVEKDPNLVSFARIIRELFVIVPQDYKAAEWSIDEFD NGSEWVRLGSVDTQRKYFKKLYFQVLRNPTLDSFARIVRELFVILPEKVEAAQWSTQEYD NHLNLVTLGKIDSQRKFFKKLYFEVSHDPNLMSLARILRELFVILPADRKAAHWSAVEYD NHEKLVTLGKLNSQRYRFKKLYLEVDRDPNLVSFARIIRELFVALPQCEMAAQWSVEEFQ RVNELVKFKNLTIGKQFFKKVYMECDDNKYLMSIAKIMREMFVENGDEIDVQQWLDEQFK GFQ--IHLSSVKYGSRFFKKVYLQVEPTPELLSLARICREDFVYMPEAQRAAEWTRNEYD PHVSLMYND-SQITKATEMVVRQRIHDAFSWR--TFKVVSCEGPVEEWQVLGSVTLPIKL PHLSLAYSDIYPMDQAMIRLIRQRIEDLLQWSFLTFKVVRCEGPVEEWEVLSEVTVPVKL PHVSLLYSDIHPVSQASLRVVQQRIEDAFDWNIGTFKVVNCVGPVEEWVVLGRVDVPVKV PHVSLLYSEISRISPAFSKTIEQRIEDTFDWGIGVFKVVRCEGPIEEWEVLGATTIPNKL PHVSLLYSDIHPVSQASLRVVQQRIEDAFDWNIGTFKVVNCVGPVQEWEVLGRVDVPVKV PHVSLLYSDIHPVSQASLRVVQQRIEDAFDWNIGTFKVVNCVGRTEDWEVLGRVDVPVKL PHVSLLYSDIHPVSQASLRVVQQRIEDAFDWNIGTFKVVNCVGPVEEWEVLGRVDV---- PHVSLLYSDIHPVSQASLRVVQQRIEDAFDWNIGTFKVVNCVGPVQEWEVLGRVDVPVKV ------------------------------------------------------------ PHLSLVYSDLYHVDQALLRVLRQRIGDALQWSIGSFKVVRCEGPVRDWHVLAAADLPLKI PHVSLVYSDVYHVDQALSRVLQQRIEDALDWSVGTFKIVRCEGPVSEWQVLGSADVPVKL PHISLVYSDLWPLHSALWRNINTRISDIIEWEFGVLKLVLCEGDVNDWVVLGSVDISIYV PHVSLVYSDMYHVNQALERVVAQRIEDAFGWGLGAFKVVRCEGPVEEWEILGSAEVPVKL PHLSLVYNDLHPIDSALWRTIKTRIQDYLTWDNGILKLVLCEGDVNDWVVLGSADLSIYV PHISLVYSDLWPLHSALWRNINTRILDIIEWEFGVLKLVLCEGDVNDWVVLGSVDISIYV --------------------------------------------------------SIFV PHVSLVYSDIWPIDSALWRNINTRILDIVEWDHSVLKLVLCEGDVRDWVVLGSVDVSIFV PHLSLVYSDLHPIDNALWHTIRSRVSDYLEWEGGVLKLVYCEGNVNEWAVLGSVDLSLYV PHLSLVYSDIYPIDKALWRTIKTRVQDY-EWDGGVFKLVLCEGDVRDWIVLGSVDVSIYV PHVSLVYSSLHPIDNALWRTIKTRIQDF--WDGGVLKLVYCEGDVGDWVVLGSVDISIFV PHMSLLYSNVSPVSRVHQRLIKQRVEDALLWGSGTFKIVRCEGPVEQWEILGKADVGHKI PHVSLVYSDLYPVEDADRRTIETRLEDTYDWKNGRFALVRCEGPVDEWEVLGVRDF-MKL LVLPVKEKDVFVYYKHGDDLVNRQSRIIRSEKWIIDKSLKLWSKLENSSKSYNKKIVLYI LVIPITNKQSFIYFKYSNELLNKESALIRYETKLSQKAANLWYSVQASQKSYNKKIVSTV TVIPISDKDSFVYYKHTESLFNSQSRILKTEKWIVEKSVKLWGKLKKSPKSYNKKIVSMV IVIPITSRESFVYFKHSPTLLNKQSALIRGENYVSDKCAKLWKRMLTSPKKINKKIVSMV TVIPITDKESFIYYKHTDNLFNSQSRILKAEKWIVEKSAKLWRKLKKSPKSYNKKIVSMV IVIPISDRESFIYYKHTDNLFNTQSKILKTEKWIVEKSKKLWRKLKMSPKSYNKKIVSMI ------------------------------------------------------------ TVIPITDKESFVYYKHSDNLFNSQSRILKTEKWIVEKSVKLWRKLKKSPKSYNKKIVSMV ------------------------------------------------------------ VAVPVTTQRCFFYFKHTDDYLDRGSRLVRAEQRVTRKVARTWAKMESSRNVVTVRVVGWV IIIPITTKKSFVYYKHSPDLIDNSSIFIRYETKISNKVSKIWTNMEDSPKGYKKKIVAWV ISIPITTSKSYIYCNHRPSTLRSKQLIYMLETNMVQIN-------QCKTKCPIKKVVSFI IAIPITNKKLFLYHKHSSDILNVGSRVVKYEAKIINKAGEIWGKMEKSPRKYSQQIVQGI LSIPITNYKSYIFCNHQPSVLDVTQWVTKLEEKITSVASKGWKKLNESEISVNVKIVRLI ISIPITTSKSYIYCNHRPTTLSPKQLIYKLENKLINLASKGWSKLTNSKQSINQKIVSSI ISLPITTKQSFIYCNHRPGILSKTQLVTKIEAKLVNLATKGWNKLTTSKLKINIKITHFI ISIPITTSKSYIYCNHRPSTLSPKQFIYKLEGKFVKLASKGWSKLSNSKQKVNQKIVDLV LSVPITTHVSYIYCNHKSALLGTSQQIVKLENKLVNVVTKGWHKLTNSKSNINRTIVRWV LSIPITTYKSYIYCNHKPSILDKSQLVTKIETKVTGIAAKGWNSLSTSKKSYNVKITNFI ISLPITTKRSYFYCNHRPSILDKSQLITKIETKATDLAKKGWNKLASSENKINKTIIKYV IVIPISKGHQFIYYHHQQEHLDTSKLIVKADQWVISKSVGLWRRLADSNRSINVKIVNWV VFTPLTARRAMVYCVQTSVTPPASQ-TPRLDDKLVKKFGTVWKQFESSETGWKKQIVFWT TKLLDTVPWSEDSLISVPNESSLLKRLKDDGDRITLKEYSSELTKSHLLPLHIYYPGPSI TKLLDQIPWTENSLRTIPSESYILKQIENGTKDVTLNEYDDSVISLKPKPIHVYFPSVVD QSLLNSTPWSENSLLTIPSESYILKRIKGETDKLTLKDYTVKAHKVDTQPLHIYYPEISN QVFLDNIHWQETSLKTIPGENHLLKRIRGQNEQVTAKQYENTLEKIRMEPISVYYPSIIG QSLLNSTPWSENSLLTIPSESYILKRIKGEKDKLTLKDYTVKAEQVDTQPLHVYYPGISS QSLLNSTPWSENSLLTIPSESYILKRIKGETDKLTLKDYTVKAKKVDTQPLHIYYPEISN ------------------------------------------------------------ QSLLNSTPWSENSLLTIPSESYILKRIKGETDKLTLKDYTVKAEKVDTQPLHVYYPGISN ------------------------------------------------------------ NVLLAQVPWRERSLASFPSESYILKRVHLQGKELTLREAQACEAGVAAAPIVVYFPSVIS NSLLDQTPWSENSLKTVPSESYILKRVQEKEQELTLKEYLSKSDELIPKPIHVYYPSVIS KKLLDTIPYEENCLKSFPTKATMIREINEESSHIVQAQVDLKISTDQLKPIPLYHPQFQN NKLLDQTPWSEDSLNTVPSEGYILKTVLENQEELTYQEWLKDVDKVQVRPVHLYYPSVLN KKLLDTIPYEENCLKSFPSQKWMIREVNDDYAKFMQSQAELKIPSSQIKPIPLYHPKFQS KKLLDTIPYEENCLKSFPSKSTMIREINEESSDIVQAQVDLKINTDQLKPIPLYHPQFQN KQLLDTIPYKESCLRSFPNKNAMIREINEESLHIVQSEVNLDIPTNQLKPIPLYHPQFQS KRLLATIPYEENCLRSFPSKATMIREINEESLHVVPGQYDLKIDTNQLKPIPLYHPQFQK RRLLSSVPYTENCLRSFPSKSSMIREINDEHLAVVTSDIKGTVSLDQLKPIPVYHPRFQE KKLLNTIPYEENCLKSFPSQTAMIREINEESLDVVLSQIDLNIPHHQIKPIPLLHPSFQQ NKLLYTIPYEENCLRSFPSRNSMIREINEEAVSLVQQEINLNIPSEQLKRIPLIHPKFQK EKLLNQLPWQEESFKSVPVEEHIIKEPGYQYVLYMLDKDDVNVGVKDR------------ NKMLEQIPYEEWGLKSIPRQSAVLRRLKQIEAKPVAEQLIAKKHHEELLKVPLVFPHLST PSQLIKSLRELSENGLAYHKKHMIYCALGLPLTIPLVLLPVVPNVPGFYLMYRLYCNLKA ESTIIAQLKQLSKKGQQYHKKHALLCALGIPISLPLILIPVVPNVPGIYLTYRLYCNLKA PGECLKQMKRLYQDGLAYHKKWTLYCILGLPLTIPLILIPLIPNVPGFYLSYRAYVNIKA RDKVEMQMTRLYENGIQNHKKYMWYCLLGVPLTLPLVLIPIIPNVPGFYLTYRAYCNWKA PDECLRQMKKLYQEGLIYHKKWTLYCLLGLPLTIPLILIPLIPNVPGFYLSYRAYVNIKA PDKCLKQMRKLYQDGLIYHKRWTLYCILGLPLTIPLILIPLIPNVPGFYLSYRAYVNIKA ------------------------------------------------------------ PEDCLKQMKKLYQEGLAYHKKWTLYCLLGLPLTIPLILIPLIPNVPGFYLSYRAYVNIKA ------------------------------------------------------------ ESVLNDELVRLLREGKQTHMRYLIYCLLALPLTIPIALVPLVPNIPGFYLAYRAYCNFKA REHVLREFESLWEVGKSYHKKYTIYSILGIPFTLPLVLVPVVPNVPGFYLAYRAYCNFKA PSVILNQLYSFEEENKKKHKNQAILCAIGIPITLPFALVPILPNVPGFYLAYRLYCNIKA EQAVREQLQALWEHGMEYHKKYTWLSILGMPLTLPLVLVPVLPNVPGFYLLYRAYRNFKA PTTILNQLYLFRDDAYKTHLKYSILCAIGIPISLPFALVPIVPNVPGFYIAYRLYCNVKA PSVILNQLYSFEEENKKKHKNQAILCAIGIPITLPFALVPILPNVPGFYLAYRLYCNIKA PSTIREELQEFRDHGLEHEKKWAIICAIGIPITLPFALVPVVPNVPGFYVAYRLYCHIKA PSTILTQLYSFEEETKKRHTRQAILCAIGIPITLPFAILPVVPNVPGFYLAYRLYCNIKA PQAILDQMHRFRDSLGARHRKLAIWCAIGIPLTLPFALVPVVPNVPGFYIAYRLYCHVKA PTTILNQLYNFRDNAHLKHFKYAVLCGVGIPLSLPFALVPVVPNVPGFYIAYRFYCHVKA PQLVLDQLRELGEVNRPTHLKYSIACLIGVPLTLPFALVPVVPNVPGFYLAYRAYCHIKA ----VNEIKKMCEDGVNYHRRHAIYCAVGLPLTLPMALLPVVPNVPGFYLLYRIYANYKA PDQAKAQLLKLAIDGAKHHRKYMIWCAIGAPLTLPVALLPVLPNLPGFYLVFRCWSHWKA FLGARHLQKIVNASDIFFYSVP---TVMSEGDNG-----------LTEEKLPIVLDQLEV YFGAKHLESLITEQKFEFINLEQYSDILKESKKEKHES-DGEKLLLSEHDLDRVLDSLEI YLGAKHLKSLLENQQLEFKELQGYSDVYKRGNSSHPQGTIAPKLLLNKQTLPLILDFLKV YMGAKHLKSMLRDTVLQFKQLEGYDSVVARGAS-----------------MDNIVSFLKI YLGAKHLKSLLEKQNLEFRELLGYTEVYKRGTSSRTQGNGAPELLLNKKTLPLILDFLEV YLGAKHLKSLLENQNLEFRDLLGYAEVYKRGNSSHSSGSDAPKLLLNKKTLPLILDFLKI ------------------------------------------------------------ YLGAKHLKSLLEKQTLEFRELLGYAEVYKRGNSSCTRGIGAPELLLNKKTLPLILDFLKV ------------------------------------------------------------ YSGARHLESMMQMQPLRFADLQEYSALMADNVAPATPG-ESERMLLDQALLPRILDNLQI YCGAKHLQSLVENQRLEFINMKEYSDIISTGLKNKPNVTDEEKMLLDHALLDRVLDNLEI LLGLQHLNYLLETLHITFKEIEGLNQLYLQHNNPNLLQDDEETVIINEDTINQIVEKFEL YCGARHLRSLVVSHKLVFTDLPQFSDILASTEKRS----HEEHLVLDEKNLERVLDSLEI LLGVKHLDYLLETKHIAFEHVDHLDAIYLSNTSLSDHNLSDEKIIITPDIIDGLCQNFDL LLGLQHLNYLLETSHIAFKGIEGLNQLYLQHNNSNLLYEEKEIVIINEEIINQIVETFEL LYGIRNLDYLLETAHLNFKPLKVVDDIYKKNAPSEVLQRDDEAMVITKDVIEELTAKMDM LLGIQHLDYLLETSHITFKSVDGLDSLYAKYNESRLLLNEEETVIINEEIIEELVEKLGL LMGVNNLSYLLETQHLTFRALPELDTPYLVDATFKKVRAENEQILLTPATLDRLVDELGI LLGVKHLNYLLEKRELAASQEDPKVKLETITDEKAILDTFKERVIISEKIIDDLCSEFSM LLGVKHLDYLLETKHLVFKDMGALSEVYEQSGINLDLDRRQEEVIITKDIIEQLCSRFDL YHGALHLMNILKEKRYRIERIDDAPKGIIPATDGESETN-----------IDQLVEFLEI LEGANHLKHLIEDNHLEFVSSEQVFDAYNKAEDTHVLKNVENSLLVDNTSIDHIVETVQL QEIENKLKKAIRQSHGSVKED--------------------------------------- HEMSTDLRKAIRQESVHK------------------------------------------ HELESDLNKVIFQKSKQQEEIKN------------------------------------- DEMSSHLNEAQRQETNKL------------------------------------------ HELESDLNKVILQESKSQEKNKI------------------------------------- HELESDLNKVIFQKSKPQDRSRG------------------------------------- ------------------------------------------------------------ HELEGDLNKVILQKSKSHGENNS------------------------------------- ------------------------------------------------------------ HELRRHIETAMRQEAMRLEEQAQ------------------------------------- HELKTDLGKAIRQEEKRLLGRY-------------------------------------- TNLKEDLLKALKQETKRLNRDIK------------------------------------- HEIRASLKKALLQERQRLETKQI------------------------------------- PHLKEDLLKALRQESHRLKKAEN------------------------------------- NNLKEDLLKALKQETKRLNRDIK------------------------------------- DNVKDELMKALHQETKRLGKQLK------------------------------------- TNLKEDLLKAYKQETKRLNKDIK------------------------------------- PALRTDLHRALAQESARIEDSLA------------------------------------- DYLKDDLLKALKQESARLSKNLK------------------------------------- GHLKEDLKKALDQESKRLRKKTT------------------------------------- PSLKHPLQKAITQELDRPKGE--------------------------------------- PDLAAELKRARRQVVYNIDKEIK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MVNTWVSSHPTLEPAAAPYTCHNARVGLVDPPPNIAYMPSCRRATSLPAYRHS ------------------------------------------------------------ ------------------------------------------------------------ ---------MGQLLSHPLTEK--------T----IEYN-----------------DYKTK ---------MGQLLSHPLTEK--------T----IIYNDYQTSGHKLSLRHDTHQEVEI- ---------MGQLLSHPLTEK--------T----IEYN-----------------EYKNN ---------MGQLLSHPLTEK--------T----IDYN-----------------DYQHR ---------MGQLLSHPLTEK--------T----IEYN-----------------EYKNN ---------MGQLLSHPLTEK--------T----IEYN-----------------EYKNN ---------MGQLLSHPLTEK--------T----IEYN-----------------EYKNN ---------MGQLLSHPLTEK--------T----IEYN-----------------EYKNN ------------------------------------------------------------ ---------MGQLLSHPLTEKTIVYNDYLL----EANGKHANLPDGSMKPYAKERHHRHL ---------MGQLLSHPLTEK--------T----IIYN-----------------DYQLN ---------MGQLLSHPIEEK--------E----LDYK-----------------SYTN- ---------MGQLLSHPLTEKTIVYNDYEH----LSHSVNRLRTSNQPTNIEKHISQRG- ---------MGQLLSHPIEDK--------TMEHKSYDT---------------------- ---------MGQLLSHPIEEK--------E----LDYK-----------------SYTN- ---------MGQLLSHPIEEK--------Q----LDYK-------------------TH- ---------MGQLLSHPIEEK--------E----LDYK-----------------CYTN- ---------MGQLLSHPVEEK--------S----IDFK-------------------SH- ---------MGQLLSHPIEDK--------E----LDYQ-------------------SH- LSLQSPLSIMGQLMSHPIEDK--------N----VECH-------------------SH- ---------MGQLLSHPLTEKSIEYNDYKQFANFVDSD-------------------RKL ------------------------------------------------------------ SSA--AGSVPRFYNCVGSMQG----YRLSQEDAHKVQNED--TILRVRFFNPFTGKHEKM ---------PRFYNCVGSMQG----YRLTQEDAHLVKTGS--ESLIVSFHDPFIGKVVKY QAS--NGIVPRFYNCVGSMQG----YRLTQEDAHLIRNEN--STVYVRFFNPFIDKYESL VSPQLSTLVPRFYNCVGSMQG----YRLTQEDAHLVLNEE--SIMQVKFYNPFKETTQKL QAS--TGIVPRFYNCVGSMQG----YRLTQEDAHLIRNEN--SVVYVRFFNPFIDKYETL QAA--TGTVPRFYNCVGSMQG----YRLTQEDAHLIRNEN--STVCVRFFNPFIDKYESL QTS--AGIVPRFYNCVGSMQG----YRLTQEDAHLIRNEN--SILHVRFFNPFIDKYETL QAS--TGIVPRFYNCVGSMQG----YRLTQEDAHLIRNEN--SIVYVRFFNPFIDKYETL ------------------------------------------------------------ HLR------RQFFNCVGSMQG----YRMTQEDAHLVSNCD-TQLVASFRNPMNNNAVEKL CNP--PGLSPQFFNCIGSMQG----YRLTQEDAHLIANFS--NHLHIRFSNPFTKQMDHL -----------LTYCIGSMQG----YRMTMEDAHDVKINE------------------HE ---------AQYFNCIGSMQG----YRLTQEDAHLVANCE--TMLGVQFYNPFLDHQEPL -----------ITYCIGLMQG----YRMSMEDAHNVKVNE------------------DE -----------LTYCIGSMQG----YRMTMEDAHDVKINE------------------HE ---------AKLSYSVGAMQG----YRMSMEDAHNVRINE------------------DE -----------LTYCIGSMQG----YRMTMEDAHNVKINE------------------TE ---------GTLSYCVGAMQG----YRMTMEDAHDARVAE------------------NE ---------DTLSYCIGSMQG----YRMTMEDAHDVRINE------------------DE ---------ESLTYSIGSMQG----YRMSMEDAHCVKIDE------------------HE IT-------PRFFNCVGSMQG----YRLTQEDAHLILNENSSDKVRVRFYNPFENRVEYL ------------------------------------------------------------ MI---------------SMFAVFDGHGGDSCSKFLSG------TSNPHLRAGLAKWVVYS QI---------------SIFAVFDGHGDNNCSNYLAGSLYEHTSTTDRILTGLIYFIKLA SL---------------NVFAVFDGHGGDDCSKFLGGGHHHRDNGNGDTSAGLIKWIAYS IL---------------SVFAVFDGHGGEDCSNFISG-------GGSNPKNGLAKWISYS SL---------------NVFAVFDGHGGDDCSKFLSGGRHHRDNGNGEPNAGLIKWIAYS SL---------------NVFAVFDGHGGDDCSKFLSGGRHHRDNGNGDSSAGLIKWIAYS SL---------------NVFAVFDGHGGDDCSKFLSGGRHHRDNGNGENNAGLIKWIAYS SL---------------NVFAVFDGHGGDDCSKFLSGGRHHRDNGNGDTNAGLIKWIAYS ------------------------------------------------------------ RI---------------SVFGVFDGHGGDECSQFLADSEK-----------GLLKWIKYS TL---------------ALFGVFDGHGGDECSKFVSG--------QERADQGLSKWITYS NL---------------AVFGIFDGHGGKNCSQYLAE--------------HLPKLVFTK LL---------------SIFGVFDGHGGDECSRYVSSENDSKQ--------GIRKWIKYS SL---------------AVFGVFDGHGGKTCAEVVSD--------------KLPTMVFRE NL---------------AVFGVFDGHGGKNCSKYLAE--------------HLPKLVFMK TI---------------AVFGVFDGHGGKQCAEYLAE--------------HLPKYIFRQ NL---------------AVFGVFDGHGGKNCSQYLAD--------------HLPRLIFQK QL---------------AVFGVFDGHGGKDVAERLRT--------------SLVPEIFRT SL---------------AVFGVFDGHGGKTCSDYLAD--------------HLVKYIFKH RV---------------GVFGVFDGHGGKECANVVCE--------------RLPSMIFKK KL---------------TMFGVFDGHGGSECSLYLSESNSSSASGKHSSHSGIAKWIVYC ------------------------------------------------------------ FENHRYGAKKNDNSTSYTRHF----------RTMEGL--ISQIIKDAYIKQDQELH--QH FESHKY------------TSFSRPDGNKRQFRTLEGL--ICQVIKDSFKACDAAFH--KH FENHHYTSSTNNDASKFKRSF----------KTLEGL--VSQILKDAFILQDEELY--RH FENHKYGAWKGVNNSNGQRKF----------RTLQGL--ISQVIKDAFLLQDNELY--KY FENHHYTSTTNNDSSKFKRSF----------NTLEGL--VSQIFKDAFILQDEELY--RH FENHHYTSSTNNDSSKFKRSF----------NTLEGL--VSQILKDAFILQDEELY--RH FENHHYTSSMKNDSTKFKRSF----------NTLEGL--VSQILKDAFILQDEELY--RH FENHHYTSSTNNDSSKFKRSF----------NTLEGL--VSQVLKDAFILQDEELY--RH ------------------------------------------------------------ FENHEYCSISD-------RAF----------CTVEGL--ISQIFRDAFALQDKDLH--CH FENHRYGSFED-DPKQYKRLF----------HTFDGL--ISQILKDSFMLQDRELY--SH L-----------------NKIASAVYLKQVKDIDLKD--VFDILKNSFFKIDKDL---SH FENHEYGPVDA-------KAF------KRRFRTIEGV--IGQILKDAFMLQDRELY--SH LSSLLKNGN---------GDL--------------AS--YMKVLKDSFFRIDRDL---TN L-----------------NKLASAVFLKQIKDIDLKN--VFDILKDSFFKIDKDL---SH LIRKRSKSRNRNSNSNSQQRA----------QLLNGE--VLRLLKHSFFKTDHEL---SN L-----------------NKLATSLYNKQLDNLNLSQ--VFSTLKNSFFRVDHDLSHQPN LNA---------------DGPQ----------VSLRK--VLAQIKDCFFKVDAALP-EAQ LNCRP-------------DKSP----------LVLAD--YLRIIKDSFFKIDHDLLLMPN ISALLDDKNVLANNILKDSKLN----------KLRSS--AMDVIRNCFFRVDHELEAYHD FENHEYGAYDV-------RKF----------RTIEGL--ISQIIKDAFILQDQELY--SY ------------------------------------------------------------ FANS-ACGSTAVVALIINGTM--------------------------------------- FANE-ASGSTAIVALLINGSM--------------------------------------- FANC-SCGSTAVVACIINAES--------------------------------------- FFNS-SCGSTAIVTIIINGEY--------------------------------------- FANS-SCGSTAVVACIINEES--------------------------------------- FANN-SCGSTAVVACIINEES--------------------------------------- FSNS-SCGSTAVVACIINEES--------------------------------------- FSNS-SCGSTAVVACIINEES--------------------------------------- ------------------------------------------------------------ FANS-PCGSTAVVAAIINSET--------------------------------------- FASS-PCGSTGIVAVIINGEK--------------------------------------- HANMVNCGSTATVVTII-ANY--------------------------------------- FANS-SCGCTGIMAVII-NSE--------------------------------------- EDSS-NCGTTAIIASIIANEY--------------------------------------- HANMVNCGSTATVVAMI-SNY--------------------------------------- YDNFINCGSTGTILVII-DNK--------------------------------------- LMNQ---GSTAIVATII-DNY--------------------------------------- AAN---CGSTAVVATIL-AGRY-------------------------------------- LVN---CGLTGIVLTIV-RDK--------------------------------------- AAN---CGTTAIVATVL-AGKY-------------------------------------- FAKS-SCGSTAVVAIII-NDK--------------------------------------- ------------------------------------------------------------ -------------------LYVANCGDSRCILSSKARGIKTMSYDHKPQNIGELIRINDN -------------------LYVANTGDSRCILSKKNKAIKPMSYDHKPQHIGELIRINDD -------------------LYVANCGDSRCILSSKANGIKTMSFDHKPQHIGELIRINDN -------------------MYVANCGDSRCILSSKGNGVKTMSFDHKPQHIGELIRINDN -------------------LYVANCGDSRCILSSKSNGIKTMSFDHKPQHIGELIRINDN -------------------LYVANCGDSRCILSSKANGIKTMSFDHKPQHIGELIRINDN -------------------LYVANCGDSRCILSSKANGIKTMSFDHKPQHIGELIRINDN -------------------LYVANCGDSRCILSSKSNGIKTMSFDHKPQHIGELIRINDN ------------------------------------------------------------ -------------------LYVVNCGDSRCILASMNSCIKTMSFDHKPQHIGELIRINDD -------------------LYVANVGDSRCILSSKSKGVKNLSFDHKPQHIGELIRINDN -------------------IVVANTGDSRCIVSRN-GHAKPLSFDHKPSNMGERVRIENS ------------------MLYVANTGDSRCVLSTKGRGVKTLSYDHKPQHIGELVRINDD -------------------IIVSNAGDSRCIMSLEGGAPKTLSFDHKPSTMGERVRIENS -------------------IVVANTGDSRCIISKN-GYAKPMSFDHKPSNMGERVRIENS -------------------LYVANTGDSRCIISTSAGAAKSLSYDQKPNIMGERVRIENS -------------------IVVSNTGDSRCIVSKN-GVAKSLSFDHKPSTMGERVRIENS -------------------IVVANTGDSRAILSLPGGLPKTLSFDHKPSTMGERVRIENA ------------------YIVVANTGDSRCILSID-GHAKTLSYDHKPVIMNERIRVENS -------------------VIVANTGDSRCIMSVN-GAAKTLSFDHKPSTMGERVRIENS ------------------NLYVANTGDSRSILCSKSEGIKTMSFDHKPQHIGELLRINDG ------------------------------------------------------------ GGTVSL---GRVGGVLALSRAFSDFQFKRGVVYKNTNPMRISANGN-------HNSPTPP GGTVSL---GRVGGVLALSRAFGDFQFKR------NVKYQNLNTLAVSSKRKYI----PA GGTVSL---GRVGGVLALSRAFSDFQFKRGVTYPHRRTKLTNVTQH-------LTSGTPP GGTVSL---GRVGGVLALSRAFGDFQFKRGVTYSYAKNKPKFHNVT-------HNGNTPA GGTVSL---GRVGGVLALSRAFSDFQFKRGVTYPHRRTKLTNITQN-------LTYGTPP GGTVSL---GRVGGVLALSRAFSDFQFKRGVSYPHRRTKLTNITQN-------LTNGTAP GGTVSL---GRVGGVLALSRAFSDFQFKRGVTYPQRRTKLTNVTQN-------STSGTPP GGTVSL---GRVGGVLALSRAFSDFQFKRGVTYPHRRTKLTNITQN-------STHGTPP ------------------------------------------------------------ GGTVSL---GRVGGVLALSRAFGDFQFKR--------------RRY-------I----PA GGTVSL---GRVGGVLALSRAFGDFQFKRGVSYT------TVHGQA-------SRNSTPA NGYILN---NRINEVLALSRAFGDFKFKLPYLSSSRNKYIKENQKLLGDKLITL----PP GGTVSL---GRVGGVLALSRAFGDFQFKS--------------RYL-------A----PA GGYVVN---GRVNEILALSRAFGDFKFKLMELLNNQNKYIAANKKYFKHELIHL----PP NGYILN---NRINEVLALSRAFGDFKFKLPYLSSSRNKYIKENQKLLGDKLITL----PP NGYIVN---GRINEILALSRAFGDFKFKIHKVQKDRQSLGSHEYIH-------I----PP NGYILN---NRVNEVLALSRAFGDFKFKLPYLSSSRNKYILENQKKFGDKLITL----PP GGYVAN---SRVNEILALSRAFGDASFKLWLELSASGSHNSYLERNRGLVHDNL-VPIPP NGYILN---NRINEILALSRAFGDFKFKLSFIETSRNKYINQNKLHFKNHLVHL----PP GGYVVC---GRVNEVLALSRAFGDFKFKTPYVDGDTNQIYARNKKYWKNGVVHL----PP GGTVSL---GRVGGVLALSRAFSDFQFKRNVQYNTNSKKSHLSSPHEHTNKNLKNTGIPP ------------------------------------------------------------ QEAQVSVEPDVLMHKLDF-NKDEFLVLACDGIWDIYNNTRLIQFIKYHLMQGMK--LDGI EEAQVTVEPDVLPHAIDL-SQDEFLVLACDGIWDVYSNKALVNFIKYHLTLGLK--LDNI QEAQVTAEPDVLMHKIDY-TKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTK--LDAI QESQVTAEPDVVMHKIDY-KKDEFLILACDGIWDVYSNKQLCKFVKFHLTAGVK--LDGI QEAQVTVEPDVLMHKIDY-SKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTK--LDTI QEAQVTVEPDVLMHKIDY-SRDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTK--LDAI QEAQVTVEPDVLMHKIDY-SKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTK--LDAI QEAQVTVEPDVLMHKIDY-SKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTK--LDAI ------------------------------------------------------------ AEAQVTVEPDVLTHSCAS-AQDQLKPQALCIMTPIYSNKALTQFIKYHLTLGLT--LDDI QEAQVTVEPDVMPHQIDF-SNDEFLVLACDGIWDIYSNKTLVQFIKYHLTLGLK--LDEI ELFQVTVEPDIMLYDMQKLDSPEFLVIACDGVWDCFKNGQLVKLIRDKLSLGWR--LNKI QESQVTVEPDVIPHRISY-DRDEFIVLACDGIWDLYSNKNLVQFIKYHLTLGQK--FDDI ELFLVSVEPDVVVYDLKSLKQPEFVVLACDGIWDCYTNTKLIKIIRDKLSLDWK--IHHI ELFQVTVEPDIMLYDMEKLDSPEFLVIACDGVWDCFKNDQLVKLIRDKLSLGWK--LNKI ESFQVTVEPDILIFDMNEQPTPEFIVMACDGIWDCFKNDQLVKLIRDKLVLGWK--LNKI ELFQVTVEPDIMVYDMSVLETPEFMVLACDGVWDCFKNDQLIKLIRHKLSLGWK--LNKI ELYQVSVEPDIMVYDLAVPQ-PEFLVLACDGIWDCYTNDQLLAVIREKLHDGWQ--LQHV ELFQVTVEPDLLVYDLQNEGVPEFIVVACDGIWDCYKNSQLIKVIRDKLALGWK--LNKI ELLSVSVEPDILVYDLSKLTAPEFMVLACDGIWDCYTNDQLLKAIRSKLAESWN--LRHI QEAQVTVEPDVLMHKLSY-SRDEFLVLACDGIWDVYSNKQLSQFIKYYLTLGMK--LDTI ------------------------------------------------------------ MTKLLDHGIAQANSST-GVGFDNMTAIVVVLNR--PDE----SLHDWMNKMKLRLE---- LAKILDHGISCADSNT-GVGFDNFTLIVVVLQQ--PGE----TLDEWYARIKSRLE---- ITKLLDHGIAQANSNT-GVGFDNMTAIIVVLNR--KGE----TLQDWFNKMKTRLE---- VTKMLDHGIAQANSST-GVGFDNMTVIIIALNK--SGE----SLSDWYTKMKIRLE---- ITKLLDHGIAQANSNT-GVGFDNMTAIIVVLNR--KGE----TLQDWFNKMKTRLE---- ITKLLDHGIAQANSNT-GVGFDNMTAIIVVLNR--KGE----TLQDWFNKMKTRLE---- ITKLLDHGIAQANSNT-GVGFDNMTVIIVVLNK--KGE----TLQDWFNKMKIRLE---- ITKLLDHGIAQANSNT-GVGFDNMTAIIVVLNR--KGE----TLQDWFNKMKTRLE---- ------------------------------------------------------------ VTKVLDHGLAGADSNT-GVGFDNMTIIIIVLNK--PGE----TLSQWYAKMKMRME---- VTKLLDHGIGCADSNT-GVGFDNMTVIIVVLNK--PGE----SLAQWYSKMKTRLE---- VEYILNDSLTMANNYT-GIGFDNMTLIIVAIHK-KEGE----TMDDWYESMKEKIL---- VRKLLDHGINSADSNT-GVGFDNMTIIIIALNR--QGE----SLTHWYGKMKSRLE---- TEFILNDCVGMANNVT-GIGFDNMTIIIVAVHN---NN----NIDEWYTMMKERVL---- VEYILNDSLTMANNYT-GIGFDNMTLIIVAIHN-KEGE----TMDDWYESMKEKIL---- VEYILNDSLTMANNYT-GIGFDNMTLIIIALHL---DGRVAENIDEWYAHMIEKIE---- VEHILNDSLTMANNYT-GIGFDNMTLIIVAIHK-EDGE----TIDKWYDKMASKVL---- VEYVLHDCISMASNIT-GIGFDNMTLVIVVLHG---SQ----TYDEWHAAMAQS------ IEFVLHECLLMANNYT-GIGFDNMTIIIVALHS---NS----NMDEWYENMKQKIL---- TEYILNECISMASSAT-GIGFDNMTLVIVALHP---TE----TIDEWYQRMKSP------ MTKLLDHGIAQANSDT-GVGFDNMTAIIIALNK--PGE----SLAEWYTRMKSRLE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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QEKGLV------------------------------------------------------ REKGLIG----------------------------------------------------- KEKGITR----------------------------------------------------- REKGLTV----------------------------------------------------- KEKGLL------------------------------------------------------ KEKGIMR----------------------------------------------------- KEKGLR------------------------------------------------------ KEKGLTK----------------------------------------------------- ------------------------------------------------------------ TEKNLV------------------------------------------------------ ------------------------------------------------------------ REKGLH------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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-------------------------------------------------MPSVDISVNQL -------------------------------------------------MPSVKIGTAQW -------------------------------------------------MPSVTIDSLQI -------------------------------------------------MPSVDIDASQW -------------------------------------------------MPSVRIDTTQW -------------------------------------------------MPSVNIDTTQW -------------------------------------------------MPSVDIDATQW ------------------------------------------------------------ -------------------------------------------------MPSVTISVNKL -------------------------------------------------MPSVTISTSKL -------------------------------------------------MPTATIDCSSA -------------------------------------------------MPAAEISVSKL -------------------------------------------------MPTTKIDYSVA -------------------------------------------------MPTATIDCSSV -------------------------------------------------MPTATIDCTPI -------------------------------------------------MPTARLDCSLV -------------------------------------------------MPSTPIDYKDI -------------------------------------------------MPSAIVDLSGV -------------------------------------------------MPTASIEYVAA -------------------------------------------------MPSVSISTKQL ------------------------------------------------------------ --KELLSKDSSTDGGSATPANTIETPLGTIMVEIQGSLELPTSIDEDSELS--------- --IDIFAEDRDTPP-------TVSTSLGHVMIEIQGDLQHPQKSIDPALDV-------DS --QKLTQSQEKQ--------TTVITPLGITMLEIQGDLELPKDFTSLAQGDSQH----EG --QQLFQSPARQ--------TSIRTPLGTAMLEIQGDLQIEANPQEENAT---------- --QKLTQSREKQ--------TTVITPLGMMMLEIQGELELPKDFASLARRDSPN----EG --QKLTQSPGKQ--------VSVITPLGMTMLEIQGELELPKDFASLAKDDSSH----DG --QKLTQSREKQ--------ATVITPLGITMLEIQGELELPSDFISLAKEDSQH----DG --QKLTQSREKQ--------ATVITPLGMMVLEIQGELKLPKDFASLAKKDSQH----DG ------------------------------------------------------------ --ASVTEGSGKP--------LTVTTELGSTIIEIQGDLQIPSQRPQEAGTDPEH------ --QSLLASKVSGDY------VSVLTPLGNTILEIQGDLDVPKTPPADDPDQ--------- --QDILNNPSTNDN------DLIFTPYGLMLLEIQGELNLPNEFPQGQPKTDEDHEYLNN --KALFQNDGT---------VAVVTPLGNTLLEIQGELEFPSEPPQAHEDD--------- --HNILNEKTLNEGELIENDKIISTPYGLSILEIQGELNLPQSFPQANENHKPE--YLEN --PDILNNNSSAQD---DNNNLIFTPYGLMLLEIQGELNLPIEFPQGQPKTDEDREYLNN CSNNTIEAEEGLLPRGNDSLSTVMTPHGLAVLEIQGELNLPDHRPVGTTQTPQT--SDSP --PDIINSNSD---------NLIFTSYGLTLLEIQGELNLPLQYPKGKPQTPEDFEYLNN --HRALNSNSLTTN---SNGCIISTPFGLSLLEIQGELNLPESAPTETEGLDPD--YVRN --RLIANSERSSVN---TPDDVISTPFGLSLIEIQGELNLPHEAPINVQKNDTNAEYIRN --ADSLNQKA----------PLISTPLGLCMLEIQGHLNLPHVASDHTHDA--------- --QTLFHSETKQ--------TTVTTPLGNTIVEIQGDLEVPLSRPSDDSASDEI----LS ------------------------------------------------------------ --KKFDGVDAVKFGSLNIED--------------KKAVLYVGKKQRLLGKVVKLSTPLGI RFIEHEGNGLVRFGILSYDLET------------KHVTLFIGNKQRLMGSIVKIEPPLGL RFSEQDGQNIIRFGLLQLDG--------------ERATLFVGKKQRLLGKVTKLDVPVGI ----------VRFGQLQIQD--------------KQATLFIGTKQRLLGQLVALDPPLGL RFSEQDGETLIRFGSLQIDG--------------ERATLFVGKKQRLLGKVTKLDVPMGI RFSVQGGQTIVRFGSLQIDG--------------ERATLFVGKKQRLLGKVTKLDVPMGV RFSVQDGQTIIRFGSLQIDG--------------ERATLFVGKKQRLLGKVTKLDVPVGI RFSEQGGQTIIRFGSLQIDG--------------ERATLFVGKKQRLLGKVTKLDVPMGI ------------------------------------------------------------ RFVEHEGRDILRFGEVSYDMET------------KKACMYVGRKQRLLGTVVKLDPPLGI RFFQQDGADVVRFGLLSLDVTQ------------KKATLYVGKKQRLLGSIVKLEAPLGM FITINEIQHAVKFGNLVFDEKDN-----------SKVTLYIGKSQRLLGNVVKLSTPLAV KFTRYHDEDIVRFGLLSLDKES------------KKATMFVGDKQRLLGTVVKLDTPLGL FARVNDIYEAVKFGRLEFDPKNQ-----------SNVTLYIGKSQRLLGSMVNLETPLAV FITINEIHHAVKFGNLVFDEKDN-----------SKVTLYVGKSQRLLGNVVKLSTPLAV YITVDDIYDAVKFGHLEFDKKDE-----------SKVTLFIGKSQRLIGNIVKLDTPLGL FITINDIYHAVKFGNLVFDPHDD-----------KKVTLFIGKSQRLLGNIVKLQTPLAI FAKVDDIYEAVKFGRLEFDEKDP-----------QKAVLFIGKSQRLLGSVVTLKDPLGV FVTVDEIKHAVNFGQLQLDEKDP-----------SKVTLFIGKSQRLLGSIVELDLPLGV -VIVDNGHQAVRFGRLEFDDTNP-----------SKVVLYIGNSQRLLGSIVDLATPLGV RFTQYKGEDIVRFGLLTISPDN------------KVATLYVGKKQRLLGNVVKLETPLGL ------------------------------------------------------------ LKF-----------------------NEG----KNVEMLDIIEYKVIFSDRP---LPIM- LKFD----------------------KAD----GTVSLRDVLKYKIIFKNRP---LPIM- MHFS----------------------SSD----NKVELVDVVKYKIIFKDRP---LPIM- MKFD----------------------KET----QKVQLMDFIEWKVLFKDRP---LPIM- MHFN----------------------SKD----NKVELVDVMKYKVIFKDRP---LPIM- MHFN----------------------SRD----NKVELVDIMKYKIIFKDRP---LPIM- MHFS----------------------SKD----NKVELVDVMKYKIIFKDRP---LPIM- MHFN----------------------SKD----NKVELVDVMKYKITFKDRP---LPIM- ------------------------------------------------------------ LRFR----------------------AET----SSVELEDVIRYKLLFKDRP---LPII- LKFN----------------------SET----RIVELEDIIKYKIIFKDRP---LPIM- LRIPLKNEDEMMVDSNNDNVNKFK--QEE----ELIKLVDIVKAKVIFKQRP---LPIM- LHFD----------------------HDL----GTVDLQDIIRYKIIFKDRP---LPIM- LRIKTETNNEDTEHGSLEE-------NKD----ESIKIVDIVKKKIIFKQRP---LPIM- LKIPLKNEDEMMIDNDDNANQ-----QEE----ELIKLMDIVKAKVIFKQRP---LPIM- LKIPLSGANGMNLEDDQNDKDKDDASEST----EKVQMIDIIKAKMIFKHRP---LPIM- LRIPTNRNGDDDDDMV----------DDK----EDIKIVDIVKAKLIFEQRP---LPIM- LRVPTGD-------------------NPT----QNMKFVDLVYKKIIFKQRP---LPIM- MKIPLNQDTSPENGNE----------KQK----EDIQIVDIVRKKMIFKQRP---LPIMQ LRIPTN--------------------GDN----HQAQMVDVIKKKLIFKERP---LPVM- LKFD----------------------NDS----GTVEMQDIFEYKIIFKERP---LPIM- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MPSRNSINRPKLTV ----------------------------------------------MPSKNSINRPKQKV ----------------------------------------------MPSKNSINRPKLTS ----------------------------------------------MPSKNSINRPKQTV ----------------------------------------------MPSKNSINRPKLTS ----------------------------------------------MPSKNSINRPKLTP ----------------------------------------------MPSKNSINRPKLTS ----------------------------------------------MPSKNSINRPKLTS ------------------------------------------------------------ ----------------------------------------------MPSKNSINRPKQKL ----------------------------------------------MPSKNSINRPKQTV ----------------------------------------------MAGRNAINKPKIKL ----------------------------------------------MPSRNSINRPKQQV ----------------------------------------------MPSRNSINKPKDKL ----------------------------------------------MAGRNAINKPKIKL ----------------------------------------------MAGRNAINKPKIKM ----------------------------------------------MAGRNAINKPKIKM ----------------------------------------------MPSRNSVNKPKGKL ----------------------------------------------MASKNSINKPKIKI ----------------------------------------------MPSRNSINKPSKKI ----------------------------------------------MPSKNSINRPKLTV ------------------------------------------------------------ NLNRKNSSISKKRDQRAGLLQPARSSADSKSGKVKSVPLDLYGQKDDHASAITNKTLSKK NLNRKVHQRAAKRDAMKGLLAPARSSGTSKSGQLKSIPLDLYKGEHSTSGALTTKTLSKK NLNHRVHSLGKKRAHRAGLLQPARSSVNSRSGEIKSVALDLYNKKDEGQTSVTTRTLSKK NLHRKAQKAGKKRAARAGQFNPARSSDSSRSGEIKSVSLDLYGKVENGAGNVTSRTLSKK NLHHKVHSLNKKRAQRAGLLKPARSSVNSKSGEIKSVALDLYNKKNESQNSITTRTLSKK NVHHKVHSLNKKRAQRAGLLKPARSSANSKSGEIKSVALDLYNKKSESQGSITTRTLSKK NLHHKVHSLNKKRAQRAGLLKPARSSANSKSGEIKSVALDLYNKKNENQGSITTRTLSKK NLHHKVHSLNKKRAQRAGLLKPARSSVNSKSGEIKSVALDLYNKKNESQGSITTRTLSKK ------------------------------------------------------------ NLQHRVQKNAAKRSARAGLLAPPRSSDQSQSGRAKSIPLDLFRGERVDQGPITTKTLSKK NLNRKVHSQARKRDARAGLLQPARSSELSKSGHVKSIPLDLYKGEQLTTGPVTTKTLSKK HAQSHAKSLGRKRAARRTTATRSSTSRYAAKGTTAPRPTDLYTGNAPQPTSMTTQTLSNK NLNRKVQTLAKKRDARAGLLQPARSHELSKSGQAKSVPLDLYRGEKSTTGPLTTSTLSKK QRNSHASSIGKKRSARNGIVTKSSTPRYETDSNAAPKATELYNGATTPTGVIINNTLSNK HAQSHAKSLGRKRASRRTTATRSSTSRYAAKGTTAPRPTDLYTGNTPQPTSMTTQTLSNK LAQSHARSLSRKRAARSSVQTRSSTSRYASKSLTAPRPTDLYTGETPLSQSMTTNTLSKK HAHSHAKSLGRKRAARRTTATRSSTSRYASKGTTAPRPTDLYTGDIPAPASMTTTTLSNK QAAHRSNVISKKKAYRRVVPTRSSNGRYNT--DTAPRPTDLYSGGLASTGNVTTTTLSKK NAHSHAKTLGRKRAARKNPSTKSSTSRYAEVSGTATKPSDLYTGEAPKPTGVTNTTLSNK QSKSHAMSLGKRRAARSVVATRSSTSRYNTETKTAPRPTDLYTGSSPDTAVVTNRTLSKK NLNKKSQRLGQKRADRKGLLQPERSSEASKSGEIKSVPLDLYNGKESNNNSITTKTLSKK ------------------------------------------------------------ RAKKIERNIKYAQQRRLLTDATDMEIDIDQKKTPKTALEQVKEALWNAVEDTSNSGLIIE RAKKIERNLKYVEQRKLLVDLQGMQIDAPVVKKKKGQLEKMREAISTVLEDIQSQGLSLQ RAKKIERNLKYAAQRKLLVDASGMDIDLDSTKKKKSSLTLVKEALWNVIDDTSSHGLLIE RAKKIERNLKYAEQRRLLTDLTGMEIDAVGGGRKKTALGQVKEALWNVIEDSSSQGLVIG RAKKIERNLKYATQRKLLVDASEMDIDLDGGKKKKSSLTLVKEALWSVIDDTASQGLIIE RAKKIERNLKYAAQRKLLVDASGMDIDLDSSKKKKSSLTLVKEALWSVIDDAASHGLIIE RAKKIERNLKYAAQRKLLVDVSEMDIDLDSAKKKKSSLTLVKEALWSVIDDTASHGLVIE RAKKIERNLKYAAQRKLLVDASEMDIDLDGSKKKKSSLTLVKEALWSVIDDTASHGLIIE ------------------------------------------------------------ RAKKIERNLRYVEQRKLLVDVQGMDIDVETAVSQTGPLQKVKESIWSALEDVAAQEMIVQ RAKKIERNLKYIEQRKLLVDVQEMEVDDASAVVAKTVLAKVKEALWNAIEDASSQGLNLE RAKKIARNQRYLAANKLKENETAMEVDNTSEQEKQTKLDQIKKALWSVIENHQKNGYSVV RAKKIERNLRYAEQRKLLVDVGGMEIDNEKSTVKKSQLARVKDAFFQAMEDTASSGLTLE RSKKIARNKKYIAKRNEKLNIDQMEVDEETEKENQTKLDKIKEVLWAAVEDRVSEGLKVS RAKKIARNQRYLAANNQKEDETTMEVDSTSEQEKQTKLDQIKKALWSVIENHQKNGYSVV RAKKIARNQKYLSQKQED----ELMMDMDKQMKEKSRLDKVKKALWDLIENFEKNGPTVL RAKKIARNQKYMAANKAATKTNSMDVDEILTEEKQTKLDQVKKALWSVIENHSKSGFSVV RAKKIERNKRYVAKRNEQLNIDGMDIDMEPQGKAPTTLDKVKEALWAAVEDSTSGDMGLN RAKKLARNQKYIDQRK---NEGEMDVEVETEEQRQSRLEQIKKALWSVVQNQSEGLYKVA RAKKIARNQKYVQQRNGTAP--DMDMDNGVA--TETQIQRVKDSLWELIKADSSAGLAPA RAKKIERNLKYAQQRKLLVDVQDMNVESNKTKGEKTPLTKMKDALWNVIEDTSSQGLTLK ------------------------------------------------------------ NGQGTVLGGPYF------------------------------------------------ TGSGTTLGGQYF------------------------------------------------ NGQGTTLGGPFF------------------------------------------------ SGQGTTLGGPMF------------------------------------------------ NGQGTTLGGPFF------------------------------------------------ NGQGTTLGGPVF------------------------------------------------ NGQGTTLGGPFF------------------------------------------------ NGQGTTLGGPFF------------------------------------------------ ------------------------------------------------------------ TGAGTTLGGQFFMTNTPLHRQAGRCTASARYSRLPTVGNCRARAAPRDGETEEGVRGAEA NGNGTTLGGPFF------------------------------------------------ SPEGTTLGIQSF------------------------------------------------ NGAGTTLGGPFF------------------------------------------------ SGNGTTLGVQAF------------------------------------------------ SPEGTTLGIQSF------------------------------------------------ PGEGTTLGVQSF------------------------------------------------ ASEGTTLGIQSF------------------------------------------------ VSEGTTIGIQAF------------------------------------------------ VAEGTTLGVQAF------------------------------------------------ VGEGTTLGVQAF------------------------------------------------ TGQGTTLGGPTF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EAEAGPAREEGAGAGVGPDTAGDLRQGDRVPVRQRVEQVRHDREGVRRVRQARVAGQPPL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PGPGPHLLAQQRAVRQAAGGRAGRGVAGRACFCPWGVLHAGACFRCRTSMRRSNTGVGYI ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSSRVN -----------------------------------------------------MLTSKS- -----------------------------------------------------MISPRVN -----------------------------------------------------MMSPKVN -----------------------------------------------------MISSRVN -----------------------------------------------------MISSRVN ------------------------------------------------------------ AMGDGVQRPAPAGEARGRRRRRRVTRIGFLLGSSLVEQQACLKKKWISALNKGLARATYC -----------------------------------------------------MSTSL-- ------------------------------------------------MSLNQYIRPVRT --------------------------------------------------MKAHLSQLRL --------------------------------------------------MKANIAMASK -----------------------------------------------MSSLNQYIRPVKS ------------------------------------------------------------ ------------------------------------------------MINTKIGRPCVR -----------------------------------------------MKHLTRAVRPLHV -------------------------------------------------MSKSYVSRIVK ----------------------------------------------------MNISLRCH -----------------------------------------------MNNNKLLFAPF-- --------------------------------------------------MRLQLRSFST -------MLK-----------------------------------------------SRF -------MWRRSISILRPSPTTVIPSNVLSGSQLELKPLFDNHAETTREDGSNV-TTTQF AR-----VWQRSISILRP-QAAKA--E--SNIVSKERTYIEELSKDI--------ATSRF -------IRVARLSTFFP-RNTR------ELIIDNITNVPKN-------------SDTNV TR-----VWQRSISLLSP-QAAKT--E--SNVVTKERTYIENLSKDI--------ATSRF SR-----IWQRTTSLLNT-QATRT--E--SNVVTREKTYIENLSKDV--------VTSRF TR-----VWQRSISLLSP-QAAKI--D--SNIVAREKTYIEELSKDI--------ATSNF TR-----VWQRSISLLSP-QAAKTE----STVVSREKTYIENLSKDI--------ATSRF ------------------------------------------------------------ LSPLMSSVSRRYISLVKP-GSSSVPPI---ARLLAPNAAAKALFPSEDL------GSTQF -------VFKRYISLVKP-TPTTIVPTQAELTAVKNTSVEPLFNGSDD-------VNTHF KLSHI--SFIRNISITQS-SINTTIKN--DESISKTTTIPENIQQAKELAGYRALEIPEF GT-----VAKRHISLVSPTAATLVPAQ--IAQKLDVEPLFGCEQKEL--------EVSQF QL-----QFIRSLIISQP-PTIALPNQ--SSNISKIENIKGNDLPNQKTL-----NDPEF RLLYI--SFIRNISITQS-SINSTIKD--NESISKTTTIPENIQQAKELAGYRALEVPEF ------------------------------------------------------------ LHQL---NFIRSITINQQ-PSSTI--S--TEQLTKTTTIPSNIQQVEELTNSRTLEAPEF -------QAAPVAASAHP-GALSRVPS--AAAVDLPAPTPG--------------DQVRL VGNIKELNFRRSVSISQA-PTGI------QGDISTTTTYEENIKNAENLKAGNVLETAEF GH-----MSRRYISIIPT-SAVGSLAI---GSKASETEFTTKLDQVNEL------NSPQF -------ANKRFITLIPN-SKV-------VKPAIDDSTGTENLFNVEDL------KTTTF -------SLRRANNVSQQ-LKD-------LPSVSGGGPFP---------------LLPQF KVVGK------------EALMASLPLEPSVPMCIRKGCLVSVMAGGA-HGSGKTASLVIG QLLGD------------NPTLASIQVSPSIPLYVRHNSIVSIH------DSDRLSNVNVS KLVDQ------------NGQIASITVQPDIPICIKKDCLVSIH--NL-------NHLSLS ELLNS------------QETIAKISFPNTTEFYIRKGSLLSLYCQSGSETNDSLDSMTIT RLVDE------------NGKIASITVQPDIPICIKKDCLVSIH--NL-------NHLSLS KLVDE------------NGQIASITVQPNIPICIKKDCLVSIH--NL-------DHLSLS KLVDD------------NGKIASITVQPDIPICIKKDCLVSIH--NL-------NHLSLS KLVDE------------NGKIASITVQPDIPICIKKDCLVSIH--NL-------NHLSLS ------------------------------------------------------------ ELLGE------------SGTLARAAVPAGTSLYVRRGCMVSLY--NR----SGLRDIAMS QVLGT------------PPSMASLTLPPSVPLYVRKGCLVSLY--GS----SSLNSISMS KTLGSTTATATGSSSSSSSSILSINVPPSVPVYIRRGSLLSIY--GI-QEISSIDSVRSQ RVLGQ------------PATLCSMKMPAGVALYVRRGCIVSLH--GA---GNDNSVLSMS QSLGQ------------PASVLAINSPPSVPIYIRKNSLLSIY--GI--DNSFVNSIKGL KVLGSTSNGGNSTSSSCSSSILSINVPPSVPIYIRRGSLLSIY--GI-QEISSIDSVRSQ ------------------------------------------------------------ KTLGN---SGSSTTSSSSSSILSINLPPSVPIYLKRGSLLSIY--GIKQDITSINSVRSS QALGS------------PPSVASVAVPPSLPVFVRRGSVLAVS--GR------IDRIVSA KALGT------------PQSVLSINCPPSVPVYLRRGSLLSIY--GL-NDSSSIKNVRSS KAVGQ------------PPSVLAVHGTPSVPLYIKKGSIMSIY--GV--QGALLDNISSR NAIGE------------PSTMASLSVPPRIPLYIRRGCIVSLY--NN--KSSKDSNISMT QPIGT------------PPSLVSVSLPASSTLFARRGSIVSIN--GQ------LDTITSR HKWVNFWTNLARFRSWNSSLYHVLTTSGKENRALVAPNISRGSPWLSALKLTDPQRSIYP YKWFTFWPTLS------LSRFDKLV-GTNTFNCLVSSRKS--------------SDTLSV YKWLNFWSNLIKFRSFRSSLFHKII-GSSSLEILASPNFQ------KSGRSFNSSRSLSV NETINKWSNLMAYSSLSASSFQKISSSTAHINILLSSNFN------SSSNK-LPNKSIYP YKWLNFWSNLIKFRSFKSSLFHRII-GSSVLEILAAPNFQ------TSRRPFDSSRSLSV YKWLNFWSNLIKFRSFKSSLFHRII-GLSSLEILAAPNFQ------TSGRSFNSSRSLSV YKWLNFWSNLIKFRSFKSSLFHRII-GSSSLEILAAPNFQ------AWRRSFDSSRSLSV YKWLNFWSNLIKFRSFKSSLFHRII-GSSSLEILAAPNFE------TSGRPFNSSRSLSV ------------------------------------------------------------ HQWLQPAARMLRYRSLKASIYYRLS-SPAHLNCLLAPNFM---SQQLWRARPVAGRTLCP HQWLQPWKKLVKYGSLSPALYHKLI-SATNFDALVSSNFKSSVIPSWLGISKTPFRTLCL LQFPNFWKRLI-YG-GYVSGYQKLI-STTPFSLLISSKSRSSGSGGGSGSGSGFEKSFVN HDWVGLAWSLAKYGSWRTALFHRLV-VPKAFDALVAPNVASNRLATWLGAPVQSFRTLCL VEFINPLKRFI-YG-GYVSKYQKII-STVPFSLLVSSSSK------NFRLRTNRQKSFAT LQFPNFWQRLI-YG-GYISGYQKLI-STTPFSLLISSKSRTIMNGGN----SSTEKLFVN ------------------------------------------------------------ LEFPLFWKKLI-YGIDSNKGYQRLI-STSPFSILVSSQSR---RGGSIFSKNNGDKSFVN F-VAPMWLRRLTLG-NIVSRYQRLV-ATEPFAVLASASAPSLWPQLVRRAT---PRSFAS INFINPIRRLL-FG-INTSSYQRLE-STTPFSLLISATYRKF----SIFKKSD-NKSFVT LSLFAPIRSFF-MG-NHNSAYQRVV-STSPFSLLISSTSK------KLFGRSA-QKTFAV HEWKSIIFNLFSYSSITSSLFIKLT-SDKSFGLLVAPNFTSNIIPLLS---KNSYSTLCT LSSLSAFARTV-QG--MPFLYNRIS-ATAPATLLVSTNTS-------------YQSSLAI LELDGTQDWNVWGRDSLIAFEQNDSLDIK--------PASLSSSLKR-----DALFSHSH LQLNGTQDWIVLNPKSVVSFEGNSSLSIQWFHKWLNYFRWISN---------KVTVLR-- LNLTGTKDWNVFGKDSIIAFEQNSSLEIKSPILPT--PRTLASSSL------KPRLPS-- IKLDGTTDWHIFKNDSILAFER--SLNLKFNQSILNIFKNITATIKE-----RHLFNK-- LNLTGTKDWNVFGKDSIIAFEQNSSLEIKSPIFPS--ARSLVSNSS------KSQLPR-- LNLTGTKDWNVFGKDSIIAFEQNSSLEIKSPIIPT--PRKLASSSA------KSRLPR-- LNLTGTKDWNVFGKDAIIAFEQNSSLEIKSPIIPT--PRSWTSSQA------KSRLPR-- LNLTGTKDWNVFGKDSIIAFEQNSSLEIKSPIFPT--ARSLVSSSA------KSRLPR-- ------------------------------------------------------------ LTLDGTSDWFVFGRDAVVAYESNSSLVIQ--EGPFRWPLRRAHPLGS------------- LNLDGRNDWFVFGRDAVMAFEGNTSLRIQ--DAPLFLRRKNKPAFSS------------- LVLDGTTDWAILDKSALQVYTGN-SLSITMHKLPKFISKKLSRSLKKDKKSNTNKLETGL LDLDGTQDWCVFGKNSLIAYEGNTSLQVNHSSLWPSWLQWKS----------ESALPS-- LLLDGTNDWAVLNNTALQAYTGG-TLNVSMFRIPKNISKTLASLLKI-----TNATETGL LILDGTTDWAILDKSALQVYTGN-SLSITMHKLPKFISKKLSRSLKNNNNSSNKKLETGL ------------------------------------------------------------ LILDGGTDWAILKNDSIQAYSGN-SLNLNIYKLPNYISKKLSKKLGF----GNKKFKTGL LTLDGTADWAVLKRDALQVYAGP-ALTLSVHAAPQRISRRLAQSLN------TSRIPTGL ISLDGSTDWSILYRDALQVYTGN-SLTVSQYRVPRTISRKLSRTLNI-----PSNTTTGL MNLEGTQDWAIINNNAIHAYFGT-SLIRRLHLIPRKISKRFAKASGL-----PLPTNTGL LNLNGSADWNIWGKNSIVAYEGNTSLNIVSNPLFN-----WRSVFKK-----RPIYSR-- VSLDGRTDWTVAQRDALFAWAGA-ALHVQ-------------PNTSL-----FGSARGGT ------KYQVVTGRGSVLLGGYG-----DIYSIDLKNSTDDIVINAQNILAVSGKG---- ------SYGKLSGRGNVLLNGNG-----SVYKLELKSEDDQIILQKNRILAFNGLN---- ------KFQILSGRGNVLVCGGG-----SVYSIELIDDNDKILVNSRNILAINGQS---- ------NFQILKGRGSVLLFGQG-----SIIPIQLKNLSDEVLVDSSNLIAINGTS---- ------KFQILNGRGNVLVCGGG-----LVYSIELIDESDKILVNSRNILAINGQS---- ------KFQILNGRGNVLVCGGG-----SVYSIELIDESDKILVNSRNILAINGQS---- ------KFQILNGRGNVLVCGGG-----SVYSIELIDESDNILVNSRNLLAINGQS---- ------KFQILNGRGNVLVCGGG-----SVYSIELIDESDKILVNSRNILAINGQS---- ------------------------------------------------------------ ------KLQLAQGRGSLLLSGYG-----TVYRVDLKDAADELILQRRHLLAINGAA---- ------KYQVISGRGNVLLSGSG-----SVYTIQLNDLHEEIIIKAEHLLGLDGNS---- FSWKKLGYTLLSGRGKVGLVGNGSSSGSSIYNINL-NQNEEILINKNNLLGITVNG---- ------TYRLLQGRGNALLSGTG-----SVYTVELPNESEELVLSSEHLLAISGSS---- FRWNNLGYALLTGRGQVGLVGNG-----AIYNINL-KENEEVLISRKNLLSISVNG---- FSWKKMGYTLLSGRGKIGLVGNGNNSGCSIYNINL-NQDEEILINKNNLLAITVNG---- ------------------------------------------------------------ ISWRKIGYILISGRGNVGLIGNG-----NIYNLNL-IKNEEILINKENLLGITVNG---- RRT---GYTFVSGRGVVALAGHG-----SVYAARV-AADEQLTVARSSIVAISVNG---- FKWNKSGFIFLSGRGQVGLVGNG-----AIYNINL-DDKEELLINRDNLLGLTVNG---- FKWYRPGYTLLSGRGTVALVGGG-----NIYNVHL-EDGEQAVVSKNNLLGLTVNG---- ------KFQTIAGRGNVLLSGSG-----SIYTIELKTKEDEIVIKSECLLGISGST---- TRW---GNTYLTGRGDVALVGRG-----QIFKIDL-SEDEDILVHPANLLAYTTSQGSAN QTETMNAIENNPFIISHT-AASNIPEFTSNVQELAAFEDPKQQQSQTIVQKTVKEAARAS KLDFKQAVTFEQTSKSLE-SDSQPET-------------IHNNEDKIAFMKTVNTTLEFL QLDIANSVERQELHVEAA-EIGDGSS----------GKRVPKFITNPTLQSAYGHTVRFF QLDINNAITSFNLKMAPSVDNKLKLI-------KARLSPLPHIIKNKSFVTNMKSVLNFA QLDIANSVERQELHVEGA-YVGDSSN----------DTVAPKFIKNQTLKSAYGHTVQFF QLDIASSVERQELHVEAA-DAGDKSN----------DNVVPRAVMNSTIRSAYGQTVRFF QLDIANSVERQELHIDAA-YIGDKSN----------EKVVLKFIKNQTIKSAYGHTVRFL QLDIANSVERQELHVESA-YVGDTSN----------DKVVPKFIKNQTLKSAYGHSVRFF ------------------------------------------------------------ PADIHACATPYDMLPPAR-AARVVPP-------------LVSLSADRRVHVEWSNLCRWF QLDIIQAVTEHSLTPPLE-KKSVKDE--------------KKDEENVSGEFDFKEFVAIT PYDLQNCIVKYEFPIINN-ANPTNTN-------INIKEPVTIVKPKLIQPTTWNLIVLKL PRDIARAVSEYRFLASPLPSAPEAPS--------------ATLTAGSTPQTSFLHSVATT PYDLQNCIVKYSFPVTKP-ETGTIGS--------TKEAPVQLNKDDVIPANNFNH----- PYDLQNCIIKYQFPIINN-SNNNNNNNNSNNMTKNIKESGNIVKPKLIEPTTWNLIILKI ------------------------------------------------------------ PYDLQNCIIKYQFPLKDQ-SIIDSNT-----------SDVIIEKPKLYEPNSWGMIKYRF PHDLHNCVA--QMPQTQA-SAAGSAG---------SATSAAGSNSRKWTDLKWKDVVPWV PFDLQNCVVEHNFTTHEK-RSESSSV-------------VQKPLGISVILKQQTTVRHKF PHDIQNSVFQYRSNLKSN-DLTIAGE-----------------KKKINPFESFSHFMSYL QLEIKDSISEQKYISNDIIDQKPQPV----------LKDVKLSDLNKLTKEEYKIYFKDL PHKLNHSAPLLQLPKLPF-IERLLAN---------------NSLLKSYLDSDFHRAVQNT KA----VWHWISYVYKKTVIFSNNNGHNIT------SPAFVKIKGPRTIIIQTSHETTQP KT----RWHTMS------------------------NTDFVRVKGPRTVLVQT------- RR--MGSWFRNQYEKR---------------YIYGIDSYFMKVKGPRTILLQTHEMTTSK KVFIVNSFHSLSWYY----------------YLWGKSPKLIRISGPRTILMQTSSFKYYD KR--MRSWIRNQYEKR---------------YIYGVDSYFMKIKGPRTILIQTHEMTTSK KR--MGSWIRNQYEKR---------------YIYGIDSYFMKVKGPRTILIQTHEMTTSK KR--MGCWFRNQYEKR---------------YIYGIDSYFMKVKGPRTILIQTHEMKTSE KR--MGSWIRNQYEKR---------------YIYGIDSYFMKVKGPRTILIQTHEMTTSK ------------------------------------------------------------ SAQASHARSLAQRLYAR--------------YLHG-PSDFVKIRGPRTLMVQSMYSGSAP TNSIVKSWNFLKHRYTA--------------FING-PTKHLKIKGPRTLLVQSSHN---- KN----FNNGFKKFFQIINKYTLGLKTTSYNYLAG-NQDFIKVIGPRNLLLQSNTNKSHR SKNAL-SWVKRVYVN----------------YING-SSKYLCIRGPRFLLVQT----SHR ------YWNIIKGYSRHIINFFKRSQRLTYNFLVG-NEDFVRVIGPRNLLLQS------- KN----INNRIKKFFQFINKYTLNLKTTSYNYLSG-NQEFIKIIGPRNLLLQSNIN--HN ------------------------------------------------------------ DQ----FNKSFKKIFQSIFKYSSDVKESGFNYLVG-NQEFIKIIGPRNILIQSNVD---N RG----VWSKLVSAPR-----------------WG--SGFVRVSGPRTVLLQSGGA---- KQ----IWSLFQYHLEASFSFLRGSRNKTNNFLVG-NQNFVKIIGPRNLLLQSSSETSHI QMITVSGFNFLKDSISRSVR-----------YIEG-TGDFVVVTGPRDLLLQSGVP---- YH--LTSWWIKKTYIK---------------WISG-STKFLKVKGPRNVLIQTGHN--VY NKSIRKTWAKW----------------------FGTGNQLLQIQGPRTILIQSQRT---- VSVSTVDILPRTVENAIPEVVETPKAKSD------------------------------- -------DAKSSAQTWPTSTLSLK-----------------------------------P DNILSKITSKGHVKKNPENDGNDTLEERV-------------------ASDVNSKIIELA GTQIQDVNNKDNLIAITRGEENLSQGEMS--------------------------IKDDT DNILTKLTSKGHVKKSNVNDNGVNLEKQV-------------------ANDVNSKIIELA DNILTKLTSKGHVKKNDGNENDADLKEKV-------------------ANDVNSKIIELA DNILTKLTRKGHVKKASGSENHVDLKETI-------------------VNDVNSKIINLA DNILTKLTSKGHVKKSNGNDNDVNLEEEV-------------------ANDVNSKIIELA ------------------------------------------------------------ LPSVPARAAPQPLYTTDMDSLPELKVSDA------------------------------- VYLPATPFSRPHVSQSPPLIGSLPIETAS------------------------------P GFNNIIPRNKPQAKVWPTNQTTTKVDESS-------------------SFS--------T AFLPTTTSTSPKSAVSSGEKAPISSSTSD-------------------TT---------T NSVGSHSTSSSELPKPNLLNIKANIEKKS------------------------------- GFNFTTRRKQQQKSIWPTTTDTTNTTTTK-------------------VDNTSS-----T ------------------------------------------------------------ SFIIPSIKRSDKIVTPVKSNDNTEVKKST------------------------------T QQMWEHTVRGPRSASAPK-----------------------------------------V ETPTPKRKNGVEVANVTGPKQ--------------------------------------T QSNLLNRAAPDQFTQSSITPKE-------------------------------------T LPNIPTKKQETNLSVPEESLLTERDAQVK------------------------------S --DLREIVSRNDLAKVGSSD---------------------------------------- --SYINYATVQPDGNVTFRSVSNFNETIAERY---------------------------- AKNYLSFAKID-NGSVNFKNTTSLLEKK-------------------------------- NRPSLFIATVSKNGKIDFQGTSKFT----------------------------------- RTNNYFIATVSENGNVKIKPSAELKEN--------------------------------- NRPSLFIATVSQDGRVDFQSTSKFT----------------------------------- NRPSLFIASVSRNGKVDFQSTSKFT----------------------------------- NRPSLFIATVSQNGKVDFQSTPKFT----------------------------------- NRPSLFIATVSQNGKVDFQSTSKFI----------------------------------- ------------------------------------------------------------ -KNYLSYASVGPDGNVSFRSTPDFKDSVKQIELAKNRR---------------------- AKNYLSYATVSKSGDVDFRSTPNFQETLENNAKLNKE----------------------- PKDYLNYVTIEPGKGAVFKSTLDFSETVESIENKNKNKNKSK------------------ SKDYLSYVTVGRDGNVQFQSTSDFSKEVAEIEAAKRK----------------------- -SDFLNYVTIEPGRGAVFKSTPNFRESVQKIEKKSL------------------------ PKDYLNYVTIEPDKGAIFKSTSDFSETIETIEKKKKNKGKDI------------------ ------------------------------------------------------------ TGDYLNYVTIEPGKGAVFKSTPDFKDTVDQIDNKSK------------------------ SADYLNVVTFDQAHRPEIRSTSDFGEAVRAIEKTK------------------------- SADYLSYVTVTPGQGVKFESTPDFKDTVDKIERK-------------------------- TADFLNYVTIDK-GKTKIESTPDFRKRQ-------------------------------- EMKYTNYVTISRSGDVKFQSTPNFNETINKLKKN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MDAIEKICLGNCKRITTV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MSSKEDNVSELSRK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MVEQLHTL -----------------------------MLGPGSAHNRRTAGGIGIGHYAGQALYFHKA ------------------------------------------------------------ ------------------------------------------------------------ --------MEEHLSMGS-VFPVHYGLQI-EIDP-AKANFKGEEQLQLNVRNNINFPKQFT ----------MILSLTEPVVPLEYTLDL-NVDH-KQPNFKGQLTVQLKQRQPGQSFNKFK -------MSDNLLSLWNPVVPCHYELGL-DIDP-SSPNFKGMAKIDLKFNPNSTSLTQFK -------MGNKILALVAALLPKNYNLEL-ELDP-SKPNFKGSLTADLRVNKKSNA-SQFE -------MSDNLLSLENPVVPSHYELRL-EIDPQSSPNFKGSAIIHLKFNPNSTTLTQFK -------MSGTLLTLENRVLPCHYELHL-DIDPQSSPNFKGSAKIDLKLNPNSISSTQFK VRLPPITMSDKLLSLENPVVPFHYELHL-DIDPQSSPNFKGSAKVDLKFNSNSTSLTQFK -------------------------------------M---------------------- ----------------------------------SRTNFKGSLRISTKFNSDNDS-RSFK -------------MEGQAVKATKYTVRL-RIGA-GQKNFQGEADVQVQVPAG--L-RRIE -----------MLAISNPVVPTRYQLEL-DIDH-TKSNFKGKLSVQLRKTNAGSF-QEFQ -----MFDPLIPLSISNEYIPIEYHYKL-DINH-QKPNFNGVAIITIDKNHSEKEKFSIT -----------MLSLTNCVLPTQYDASL-QLDH-LKANFRGSLRVHLKVQSGIQEVREFS LDESQIDTSLKLLSLRNQYIPEFYDLHL-NINH-LKPNFNGTVTIDIKKNENYHGSFRFT -----MSDTLIPLSISNEYVPIEYHYKL-DINH-QKPNFNGVAIITVGKNDEEKP-FSIT ------------------------------------------------------------ -----MTDSSKPLTLSNKYIPSEYHYQL-NINH-QKPNFNGSASITLIENKDYRSGFKFT --MSSEAGIASSLVLVNAFLPKSYDLKV-SVDH-SKPNFSGSVVIPLTKNDDSST-FSMI QSIAIEDESAPSLAVSNRFVPALYELKL-DINH-TKPNFQGQLDILLKENDVYNV-ERLQ ATSEKPPDLMRPLTLENAYLPTRYAVDV-KVDY-AKPNFSGQLVAEIDNDDE----FRLV ---MPETNTVELLSLGSPIIPINYKLDL-EIDP-AKANFKGECVVTFNSREN----NSFK ------------------------------------------------------------ LHGTDLVVLSAEL-STGTNFD-----QFEITYKKEEQEIVLKDM-SISN-NA--ALKIKY FHCKQLIVTKVLL----------SDKPLSISYDANEQTVSFSSDDPLNIADDTAELRISY LHSRDLVVLSAHA-TVGSAKF-----DLKVSQDTQNSWSVFQLPIQLSN-ESPLVLSVQY LHSRNLVITSASI-TTEAREY-----PLTVSCDETAQLAVFQFSNSLPSLSETIQLNVKY LHSKDLIVLSAHA-TIGSTKF-----DLKISQDTGKHLSIFNSPIQLSN-DCPLILSVQY LHSKDLVVLSARA-TVDSAKF-----DLKVSQDTQNHWSIFQSPIRLTK-ESSLVLSVQY LHCKDLVILSAHA-ILGSTEY-----NIQVSQDTKKHWAIFQCPIQLSN-DLPLVLSVQY ------------------------------------------------------------ LHCKDIIILSAKA-GKHGENL----QNLKVSYDRQGQTAIFH--AQEPL-NDSDEIELQY LHAAELAVVRAAL----------GDTPLKVRYERERERCVLEADQELA--GGAGKLQLAW LHSKELVILQATV----------GGKPLSIAYDRPQQLVNFK-SDALID-TQDLTLELSY LHANKLVIISATI----------GDEKLSIKYDKLQQRVTFSSSSQLVT-NNCLVMEVKY LHGQNIIVLSAHI----------GSHKLAVSYDREQKLITFKTPIGVSD-GIIQPLVMDY LHANKLIITKAIL-NDGGKTT-----DLKVDYDRGRHEVSLTINYEWKS-PEKAKITLMY LHANKLVLTSAII----------GDKKLSIKYDKLQQRVTFLSPQTYSQLDNCLVMEVKY ------------------------------------------------------------ LHANKLVIITASI----------GDKKLKVEYEKELQRVSFTSEESISI-DQ--PLKINY LHAHKLVVMKATL-----QMSDVGSIPLKIVTLRDRMMISLSTSSQITE-KASPTVTISF TSTKSLSLHASKLVITKAVLNTTSEVKLTVKYDRINSQVTLSSSEDVEIVVANLKVSITY LHAHKLVIMSAQV-SCESQPA----KKAQIAYDRQAQTVTLTVPEKLPN---KVSVHISY LHAKDLVIASATI----------GDYQLKVKYEKEQEIAIFSHDTPIDV-SNHNEILIKY ------------------------------------------------------------ IGKLNDDKTTGVFKTNYMGGYHD-----DQKSNNIVISTHCQPTFARSIFPCFDELSSKT IGKVNTELTTGLFKTNFMS--DT-----TGISDSYILATHTQPVFARSIFPCFDEPNSKC VGKIRSDVTFGIFKTNFMD--PK-----TGTSNNHVVATHCQPFSASNIFPCVDEPSAKS VGSVQQDQTVGIFKSSFND------------GKNHIFATHCQPSFARSIFPCIDEPSFKC VGKIRDDKTFGIFKTNFMD--RK-----TGTANNHVVATHCQPFSASNIFPCIDEPSNKS VGKIRNDATFGIFKTNFMD--PK-----TGTSNNHVVATHCQPFSASNIFPCIDEPSNKS VGKIGNDKTLGIFKTNFMD--RK-----TGTSNNHVVATHCQPFSACNIFPCIDEPSNKS ------DHKTG-------------------SANNHVVATHCQPFSASNIFPCVDEPSNKS VGRINSDVTTGVFQTNFMDQETG-------TSDNYVISTHCQPTYARTILPCLDEPDVKA VGKVGQDATQGVFRTNVMSETTG-------RCDAQVVATHMQPTLARRVLPCFDEPVAKA IGKINGEPTRGIFKTNFMN--QQ-----TGSSDSFAIVTHAQPTFARMILPCIDEPNHKA MGQIKTDETQGLFKTNFLDNDSG-------KSDNYILTTHFQPMGAKQVFSIIDELTHKP VGTIHTDATTGVFKTNYMD--NE-----MGSSDNYVVATHAQPGFARMILPCIDEVNHKA MGQINTDQTKGLFKTNYLDSISG-------RSNNYILATHTQPHSCKLIFPLVDELNFKV MGQIKTDETQGLFKTNFLD--ND-----SGKSDNYILTTHFQPMGAKQVFPIIDELTHKP ------------------------------------------------------------ MGQIKTDVTQGLFKTNFLD--ND-----TGKSDNYILTTHFQPHGAKQVFPIIDELTHKS MGCINSDDTYGVFKTNYSDSIEG-------KSDNFVIATHCQPFGCRTIFPVIDELVIKV MGQINSDKTHGLFKTNYLDSVSG-------KSNNYILSTHFQPHSAKLVFPLIEELHVKT MGQINTDTTQGLFKTNYSDAIEG-------RSDNLIIATHMQPHGARLVFPVIDELSLKV VGKINGDKTVGVFKTNFMD--DK-----TGSSDNVVVATHCQPCFARYIFPCIDEPSNKS ------------------------------------------------------------ TFQLSLTSLSRFSAISNS-KVLKTEER---ADGGQKTTHFEKTPLLPASLFGFSIGDFRK KYQLTLTADDKFKVISNTSVENRSVTD-----DRKQIVKFSKTPLMNTSYFGFCIGDLEF TIQLNITMNSQYKAVSNAAIEAIETLD----NPQRHLVKFATTPLMTTSVFGFALGDLEF SIQLSIKTLTGFKVLSNVSQQSIETTT----KNGYKLVKFNKTPLMTTSVFGFVAGHLDV TFQLNIATDAQYKAVSNTPVEMVEALD----SSQKHLVKFAKTPLMTTSVFGFSIGDLEF TFQLNIAMDSQYKAVSNTPVETIEDLG----NAQRHLVKFTVTPLMTTSVFGFAMGDLEF TFQLNISMDSQYKAISNTPVEAIEALK----TAGKHMVKFARTPLMTTSVFGFAMGDLEF TFQLNIAMDSQYKAVSNTPVESIEALD----NAQKHLVKFAKTPLMTTSVFGFAMGDLEF HFQLQVKTWQRFKVISNVAAENQEANDADNNNNNWQIVKFGRTPAMATSLFGFTIGDFEF IFQLEVTCPEQFKVVSNAEV-EARECD----ASGMQTVWFRETPRMTPSLFGFCLGDLDF HFQLSVKTNERFKVMSNTPSRKTDLPE-----TNEQLISFNETPLMNASLFGFALGDFEF MIKLDLKTLKKFQVFCNGDEEDVVSND-----DEWKISKFVYSKPIHPAIMGFSIGDFTW QFKVDITTHERFVVISNTAAVKEVLIP----ESKQKLVQFDLTPLMTPSLFGFVLGDLQC PIKLTIDTLSSFKVLSNSLIAEPCPVP----MSENATFAFKPTPPIASSVFGFIIGDLEY MIKLDLKTLKKFQVFCNGDENDVVFND----DDEWKTSKFVYSKPIHPAIMGFLVGDFTW ------------------------------------------------------------ MIKLDLTTLKRFQVCCNGEEKDSIFHE----ENENKTTNFVYERPIHSAIMGFSIGDFNW PIKLTITTKSSFKAVSNALLERTTIVD----MTENSVFEFKPTPPISPSIFGFVIGDLEC PIKLTITTLSKFKVISVGKLLLNQPLE----MSENSTFSFETSPPIAPSVFGFVIGDFEY PIKLSIETRDDFSVASVGILEKKDQLE-----DGMAKFHFKETPPIATSVFGFVAGHFDH SFKLTLRTLKKLQVIGNTKIESIANDS----LTDFQVVSFTKTVLMTTSLFGFVIGDLDF ------------------------------------------------------------ INTVT---EFDGISTEIGIYSPW--RV-EATYSLDIMKKYIPLLSSYFNFSYPSSKLDIV LRTDV---KLKNKTIPVQLFAPQ-SIS-HATYSFDTIVELLPIVEKRLGVDYPLEKLDVV LKTEVKLQ--NKTTIPVSIYAPW-DIA-NATFTLDTIQKYLPILESYFQCPYPLPKLDFV LKSQVPEQEVGYPMVPIAVYSPI-QIN-DATFTLDTILKYLPKLQSFFQNKFPLDKLDFV LKTEIKLE--GDRTIPVSIYAPW-DIA-NAAFTLDTVQKYLPLLESYFKCPYPLPKLDFV LKTEVKLQ--NGTAVPVSVYAPW-DIT-NAAFTLDTIQKYLPLLESYFKCSYPLPKLDFV LKTEVKLK--SDKTIPVSIYAPW-DIA-NATFTLDTIQKYLPLLESYFGCSYPLPKLDFV LKTEVKLK--GDRTISVSIYAPW-DIA-NATFTLDTVQKYLPLLESYFNCSYPLQKLDFV ISTQIKS-TSGSKTIPLRIFSPW-EIT-QAAFALDTVQKYLPILEQFFGQSYPLDKLDFV LQTEARS-ELTGQTVALRVFSPQ-RIQ-DAAFGLDVLREYLPRVESWFGNPYPLKKLDLV IQSLVKLP--QGD-VPIRIFSPQ-QIT-DTTFALDTIIETLPRLQKFFGCNYPLDKLDFV QSSKTVKT--NNVEDSVRVYAPS-GEISKTNMALRIIEKYLPKLEAVFG-KYPLNHLYFV IETRVTLP--QGD-IPIRFFAPQ-QIE-NATFGLDTVRDMLPAVQNMFKLDFPIGKLDFA LE------NNDDV-IPVRMYAPI-GTLSSCSYPLYVISSLLPILQELLNIKYPLDKLDFV QLSKTVKT--NNIEDSVRVYAPS-GEISKTNVALRIIEKYLPKLEAVFG-KYPLNHIYFV ------------------------------------------------------------ QSSKKIKV--NDITDSVRVYAPNGDLS-KTNLALSIIEEYLPKIEKIFG-PYPLNHVYFM VE------CLDSS-IPIRAFVTK-GDGPLINYALKVAEALLPKFVDTLGVQYPLEKFDIV LE------D-KYGDLPLRVYTSI-GESRYAIRALKLMKKLLPILESLLDVKYPLEKLDFV VEA-------HVSGIPVRVYALK-GEAENAQAALSLITKLLPTLEDLLGCKFPLDKLDFV IKTEVKM-PISGTDLPIAVYAPN-NVE-LATFTLNTIQKYLPLLESYFNKCYPLDKLDFA ------------------------------------------------------------ LLPFLSDMAMENFGMISIQAAHLLISPMLANEEVRKQLHQLVVHELVHQWIGNYISFDSW LLPFLSDMAMENWGLLTFQMNHLLLTPALSDPSVIQQVRQLIVHELCHQWMGNYISFDSW LLPYLTDMAMENFGMITIQLNHLLLPPALANDTIREQAQQLIVHELVHQWMGNYIAFDSW LLPFLNDMAMENFGLITIQMNHLLLSPNLSNNMIRLQCEQLIVHELVHQWMGNFVSFDSW LLPYLSDMAMENFGMITIQLNHLLIPPALANETVREQAQQLIVHELVHQWMGNYISFDSW LLPYLTDMAMENFGMITIQLNHLLIPPALANASIREQAQQLIVHELVHQWMGNYISFDSW LLPYLSDMAMENFGMITIQLNHLLIPPALANESIREQAQQLIVHELVHQWMGNYISFDSW LLPYLSDMAMENFGMITIQLNHLLIPPALANESVREQAQQLIVHELVHQWMGNYISFDSW SLPFLTDMAMENFGMISIQTSHLLIPPMSADVYTRQQSMQLIVHXSVHQWVXNYVSFDSW LLPFLSDLAMENFGMITVQMTHLLLTPNQLGGQRRTQAIQLLLHELVHQWMGNYISFEAW LLPFLSDMAMENFGLVTIQMSHLLIPPALNNRTTRQQVRQLVVHELVHQWMGNYISFDSW AVPFLKDGVMENWSMINVIAPNLLINDNNNNNQPETQLTELIVHELVHQWIGNWVSFDNW LLPFLSDMAMENFALITIQQDHLLLTPALAESSSRLRVQQLVVHELVHQWMGNYISFDSW ALPFLSDGAMENWGLVTVLSSQLLIDE-SSHESVKLQLRQLIAHELVHQWVGNLISFDEW AIPFLKDGVMENWSMINVIAPNLLIDENYSNNQDETQLTELIVHELVHQWIGNWVSFDSW ------------------------------------------------------------ GVPFLKDGVMENWSMINVIAPNLLIDDNAVTKQFKSQLTELIVHELVHQWIGNWVSFDNW TLPFLSDGVMENWGMVTIFRNSVLMDANNADDSGKFQVRQLIAHQLTHQWIGNLVTLDDW SIPFLNDGAMENWGLVTVLSNQLLVDESTASPSTLRQIDQIVAHELVHQWIGNLVTFDDW ALPFLSDGAMENWGLVTVISSQLLI--MDSDEVSLQSLHQLLAHELVHQWIGNLVTFEDW LLPFLNDMAMENFGLVTILQDHLLLPPALGNKFIRQQSQQLIVHELVHQWMGNYITFDSW ------------------------------------------------------------ SHLWFNESFATWCSSHILEENGDLADYWNS-IDYIENQLQPSIERDSDIAAQSIVEMAKH DHLWFNEAFATW------FACDLNDGYWSS-DVYL-TQMENVISTDEVTTKSITQGSVID EYLWFNESFATWLACHVLEQNGDLPQYWTS-EPYLLQQVEPIMCKDDFNSKSISQITQRK SHLWFNESFATWLACH-LVSDNDSHSYWNS-DAYLLQQLEPQLISDSTITRKSIMDDISQ ESLWFNESFATWLACHILEQNGDLSHYWTS-EPYLLQQVEPTMCRDDVNGRSIFQIAQRN EFLWFNESFA-------------------------------------------------- ESLWFNESFATWLACYMLEQNGDLPHYWAS-ESYLLEQVEPIMCKDNVNSKSIFQIAQRK ESLWFNESFATWLACYILEQNGDLSHYWTS-DPYLLQQVEPTMCRDDINGKSIFQIVQRN GHLWVNES---------------------------------------------------- EHLWFNEAFATWLA---CSLCEGLDEEWLGWEDIIEKDAKP-----EVKSIVDLSRPSAV EHLWFNEAFATWCACHVLEKIDN-DEYWIS-DEYL-QQLESVIVQDSKFSTPSILESSRK GCLWFNEAFATWAARKIIGTDT--------TTSRSSNNNNNMLAIDKIGSIFQYMERHQN DHLWFNEAFATWCACEVLSDVTG-NDYWSS-EDYL-FQLDTCLKGDSSPDAQSIAKSSKT SNLWLNESFATWLGNYLLHVARLDKADYEN-DAFELRDQESIMDQDSLPSIHQITSGMNS SCLWFNEAFATWIGANTTHSNDEMLSFYDD-GDFKIGSIFQYMERN--------QSPGLN ------------------------------------------------------------ NFLWFNESFATWAA---RKFIGIPFN----YDNFL--TIDCFFDGDKIGSIHDYMQKVNA KYMWLIEAFATWVGNYLLSLAKI---ENSDFADYEVISMESFMDKDCLLQNHMMKLRLNK KYLWLNESFATWLGNYILDVADNSHPKDKEFEKFL--DQDCFYAEDSIPSINTYMSKIDT RDLWFNEAFATWFGNYALYLVG-LYPNFKL---NMILDYEKMMDRDIIPSIHDCTKSLST EHLWFNESFATWLACHLIDQEGDTENYWSSFEY--LKQLETTMESDDVKAAKSISGSAKK ------------------------------------------------------------ SESLRTHEIFDAHSYNKGIALLRCFQLTVGSDMFRKAFQEIFNEHFHKAIKPIDIFNKIG VKLQSTSDAFEPHIYHKGISLLRSLQQSVGKENFNRALAQIFSTFHETCIKPMDIFRRMG TSNSHTSDIFDPEAYAKGIVMLRSLQLAIGETHLQKGLQSVFKTFHERSVKPMDIWNHIG LDNKQTNDIFNHIAYTKGITMLRSLQLCIGDQLLSKAMSDLFALFHEKSVKPMDIWNHVG TGDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGLESVFKTFHARSVKPMDIWNHIG ------------------TC-----------------LACYI------------------ TSNSQTSDIFDPEAYTKGIVMLRSLQLATGESHLQKGLQSVFKTFHERSVKPMDIWNHVG TGDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGLQSVFQTFHERSVKPMDIWNHIG ---------------------------------F-------------------------- LR--STSDIFNAHTYNKGIALLRALSEMVGKQKFQEGVRSLFKLFHEQAVTPMDLFEYMQ SKVTQTSDVFDPHAYTKGITLLRSLCCCIDDEKFANSWSKVFSLFHERSIKPLDLWSFIG PNNATTESIFSTNIYEKGIILLDMIDGIFAEGKFLKQFANKIEKYQSKTIKIFDIWQNLN ESILHTADAVDPQNYAKGISLLRSLQCSIGKDNFKAALQKFTPDYHNRGIKPTEIWTFFG SLSECTQDLFDKTTYEKGIILLSMIGSILENENYLNGVAKAIEKYKFKNIKPFDLWNVLN AT---TESIFSTNIYEKGIILLNMIDGIFEAESFLREATKIIEEYQSKSIKIFDIWQKLN ------------------------------------------------------------ GLNATTETIFNTEMYEKGMILLNMIDGIFGKDM-LSSFKIIIDKFQGKAIKVFDIWQELN DS--RTNSIFERDAYEKGMILVNMIASLFNEESFFSALKNVLEGCKHQTIKPFELWQQLN GLNSLTSTIFDTHAYEKGIILLRMIGNIIGDPTMLRGIGALIKKYQYKSIKAFEIWNTLN GL--ETSTLFDRTAYEKGINMLNMAANLVQQDTFSSAVSKVIQAFKFKSIKAFEFWNVVN ITVNQTSDAFDAYTYTKGITILRMIQKTVGDEILKESLQKIIERFHAVSCKPIDIWTEIS ------------------------------------------------------------ SFLSENIPKFYTSWTRTSGVPIVSVEELDG--KTKLIQHRYIPYS-HGSEHEDIPYYVPM EILSENIANFYSSWTRTPGIPIISVNTDTE--RTTLEQHRFLLEK-TDVE--DIPYHIPL KTLSQNITNFVSSWTRTPGLPVVKVELEDHDGQTKLTQHRFINQLSEKAQLEDVPYQIPL KFLSENIPNFMSSWTRIPGFPLLSVSKEDAE-STNLVQHRFLVDSKLDQ-VEDVPYHIPL KFLSQNITNFVSSWTRTPGLPVVKVEVEEKDGQTKLTQHRFINQLSEKDQLEDVPYQVPL ------------------------------------------------------------ KTLSQNVTNFISSWTRTPGLPVVKVELKQDDGQTKLTQHRFINQLSEEDQLEDVPYQTPL ITLSQNITNFVSSWTRTPGLPVVKVE--LEEKQTKLTQHRFINQLSEKVQLEDVPYQVPL ------------------------------------------------------------ EILGLQVIEFVTSWTQTPGVPILHVSIDQDG-DTIVEQHRYSDVT-----DNDPIFHIPL QELSANIPNYVSSWTRLPGSPLLTVTKEDG--VTKLEQHRLIFTE-EHDE--DVPYHIPL DDISIDLPSFVYSWTRSKGYPLLRVTNGSLAKKIVIEQHTYFHNITEKAGIEDTPYHIPL KQLSANIANYMFSWVQTPGFPVLHVTQENG--ETKIVQHRFKSSA-NDE-FEDVPFHIPL EFTSIDLLSFVHSWVRYPGYPIVNVKTKGD--KIVIEQHRYLFNN-KAQDLEDTPYHLPL DDISIDLPSFVYSWTRSKGYPLLRVTHQETGNKIAIEQHTYFHNMTTKEAIEDTPYHIPL ------------------------------------------------------------ EQVSVDLPSFVYSWVRSKGYPILQVSHKGE--KILIEQHAYFSNLTVEQQIEDIPYHVPL SYLSVDLLTFVQTWTQYEGYPLVKVKISGD--KIKFEQNRFFFNDDVN-NLENPPFHVPL ELTSIDLQSFVHSWLRYPGFPLVQVTTND-DNKLLFEQHQCLYNL-RADQLEDHPFHVPL DHASADLNAFYHSWVRQSAYPILQVSRADD--TITIEQNRFIFNSDSQD-IENSPYQVPL KMNSENIVNFFSSWTRLQGFPLITVTTDQNS-NTKLTQHRFVIKG----EDEDIPYHVPL ------------------------------------------------------------ FSIL-ADGSKDKK-NILLTDRSLTID------NTILMLNHNGQGYFRVSYESETIYDTIV FAVQ-SSGEDDTK-NGLFTDRTLKLS-EP-----ELIVNSGARGLYRVSYETDKCYELIN FGVL-PDGKLDTE-NVLLTDRTLTLN-YS-----LLALNHFAQGYYRVSYESKECYTQIS FIKL-PNGELDKE-NILMTDRTMNLK-YP-----ITLCNHNAQGYYRVSYESGLCYADFI FGVL-PDGKMDTK-NVLLTDRTLKFD-YP-----ILVINHLAQGYYRVSYESEECYALIN ------------------------------------------------------------ FGVL-PDGEMDSK-NVLLTDRTLKLD-YP-----ILVLNHMAQGYYRVSYESKESYTLIN FGVL-LDGKADTN-NVLLTDRTLKLD-YP-----ILVLNHLAQGYYRVSYESKECYAKIN ------------------------------------------------------------ MIRD-QEGKFLLD-CPYMDHRKISLTGLN-----PLFLNADSKGLYRVSYESLACYEKLK FIRL-PDGTIDKE-QMLLTDRSTSIS-YP-----ITMFNADSQGPYRVSYQSAWCSEEIN FITS--GNNEDSSHNLMMTDRSIELD-IDYHQ--LININTGHKGYYRVLY-DQLDVGNLS FTKL-PDGSIEQE-QALLTDRSMTLR-FP-----IVLFNSDVQGYYRVSYESLSCYDHIA SIKCIDDKKNIKILNIMLTDRNLEVP-IP--LDQFITLNSNKSGYYKVVY-SQEFIPHVC FIKT-TDGNENNKKNLMMTDRSIELD----IDHQLININTGYKGYYRVLY-DHFDVDNLS ------------------------------------------------------------ FVKA-ENEKGEIKINLIMTDRSLELD-IS----KLVCINSGHKGYYRVLY---DRIDNLS SLKILTETKEVKLVNLILSDRSMEVDIVP---SSLISVNANKSFYYRTVY-DPKFVPIVL FIKV-IDDKGSSKVNIIMTDRTLELD-IS-LAQ-LVNINHNHSGYYRVKY-SPKLIANII SIKVLDDNGDVKILNLVLSDRRTEIN-LP--SSRLVLFNFNGSGYHRVSY-SEMLIGEIC FILK-RDGTIDNS-NVLMTDRSIELK-EA-----ISLINSGHQGYYRVSYESDEHYVEIR ------------------------------------------------------------ E--NLQNSKLDDNNLKTILIDLAYFIGDKYQKDVHIKGLFKILSAFAANSSVIVYWCGLS E--ALKNSKISDLDLFKIFIDLRSLIGSEYQKKIHIDGVLMILRCLDLTEELYRGLSIGL E--KIIEGTLSEIDLWKVFLDLSQFIGDSFQKSIHLLGLCEILSHIASSSSNIPYWGPLS K--QIEEDKLSQLDLMKIIVDLSHIIGNPNYEPIHLLGFFKLFKYLEKVTKKPDLWEPIS D--KITEETLSEIDLRKIFLDLSQFIGDGFQNSIHLHGLFKILNHI--ASPSTKYWDPLS ------------------------------------------------------------ D--KLNEGTLSEIDLSKIFLDLSQFIGDGFQNSIHLLGLCSILSNIASSSTKVSYWAPLS D--KLTEGTLSEIDLWKIFLDLSQFIGDDFQNPIHVLGLCKILSHIASSSSKIAYWAPLS ------------------------------------------------------------ K--GITEGKLSSTDLYRFFTDIDAIIGSRYQKPIHLQGLHSVLAHMD-IGNYFHGLAIGL A--ALSQGTLSATDLYRIFQDLSFFIGDKYQKEIHITGVVTLLEHIKKNPQYYHGLSIGL --------LMDPKDIITIISDLGTVIGTPNSNSQDLINFIILMSNL---ETQFNIWECAL E--AAQKGVLSELDFYGIIRDLSEFIGNGIYQQEHLDGLIKLLETIK-YPQYMLGLGLGL T--NIINNNFTPQEIISIINDYGKLLGQENSTSHHLVAIFAVLNCFSKWEINYNVLKVGL --------LMDPKDIIMIISDLGTVMGTNSNS-NDLINFISLMGDLKSKEFNWEIWECAL ------------------------------------------------------------ --------LMDTTDIIMIISDLGSVLGS-PVSSRDLCNFIKLYDNLLSISWDWSIWECAL K--NVASNMLPSLDLFGIINDYGKILGQEFGS-NQLMTLLNICDALEEWEDDFNVLRCAL E--NID--KVSLTDLITIINDYGKLLGSGTTK-EDLISLVQIIEAVR-SHIDYDLLQVAM S--NVK--YMSTEDQISFIFDSGKLLGQLYTE-NSLKTLIAYLRVL--SQPEWKVLTMAM R--LIEEDKLEVVEVYKIMEDLCYVMNN-YGKEVHESGLLTLMDCI--IDREDY-WSAVS ------------------------------------------------------------ TALDIVRRIHSTLGAAQKAKLANK---IVDPLFRAMKWPNFATSMESNETKVRGDILYLL DILQTIENALRTY---TGKSEKAFITDIYVPLWDKFSWNDFHV-SSYQLKVMSKVMFGIK KGLEILQTTDRAI--LSSSKLQSFLRKIIIPLFDKIDWPEFDKTDPYELKVMSQVLFLNK QCLSILEAIQLSVRVYGKGSKSPLGLDIITILWNAI---NLDTKSTYELQALGSLLTLTK KGLEVLQTIDRAS--LTSSKLQSFLKKIVIPLFNKIDWPEFDKTNPHELKVMSQVLFLNK ------------------------------------------------------------ KGLEILQTIDRAS--LTSSKLQSFLKKIIIPFFNKIEWPEFGKLDPYELKVWSQILFLNK KGLEVLQTIDRAS--LTSSKLLSFLKKIVIPLFNKIDWPEFDKANPHELKVMSQVLFMNK ------------------------------------------------------------ RTLQRLELSLMTYGMLRSDYLST----VYQPLFKKLQWPLVSTHSQWELEVMLQILFGMR EILQTIERSIITYGFSSTNSCES----IIKPLFKKLSWPDFSKHSHYELEVMSQLLFASK SYLEPIIDILRHF-SEFNKFNTNWLNKFVSDLFKAIKWDNSLDKNHYNSLEWKVRLQLNI KTLQQVEVSIMRY--SDNNKKYDFNSSVYSPLFRQIEWPDFIGGEKYDLELMSQVLSSGK DYLETISNILLHF--SSYSEYERWLENYITKLFNKIGWELYQLTSDYSLIEMEVRNLILH SYLEPIIDILRHF-SEFDKFNNQWLSKFTGDLFNAIKWDNSLDRNQYNSLEWKVRLNINN ------------------------------------------------------------ GYLEPIIDILRHF--TDFTKFEQWVNKFSNKLFQQLKW-DYDIPVRYNSLEWKVRSSILQ DYLEVVNTTFVHF--SRYIEFKRWLDKFSLKLFNKLGWDVLDSGNEYDVSEYQVRNMVLQ TYLETINSNLMHF--SKYTEFQVWVDNLVSTLFQRIGWDSFKDSHCYDPVEMEVRILQIG NYLETLNAILLHF--SHYSAFQNWLARYTAELWSKLGWDNLTNNYSQNEMLSRNSILLLS IGLQMLS------QRKLTDNLKY--KKMLDKLVSKMNWNKPSELDEDKVSVMAQLMYMYR ------------------------------------------------------------ QDVKDINVYSLADNYFKAIMT-GPASSIPIGLIGGVFLLVSRFKNVKQWKKLFELVKKHT HLDS---TLTVANQLMKKILS-GPNKSIPLELCGSVFATVSCHQNVKQWKKLYELVKDGS N---SQKCDELCQIYFRHLLQ-GPRSSVPLEIVNSILVVVSQHCNIKQWKKIFDLVKSGD T---EPRSVEVAESYYSTLRSSSDNKKVPSELVSSIFQVIVANLNVKQWKKFHELIKNIE NSAK---CAELCQIYFKHLLQ-GPRSSVPLELVNSILVVVSQHCNIKQWKKIFDLVKNSS ------------------------------------------------------------ TSAK---CAELCQGYFKLLLQ-GPRSSVPLELVSSILVVMSQHCNIKQWKKIFDLVKNSG NSGK---CAELCQIYFKHLLQ-GPRSSVPLELVNSILVVVSQHCNIKQWKKIFDLVKNSD ------------------------------------------------------------ Q---DPAAYELCARYYKHILQ-GPNKSIPMQLVGSIFAVVAENMNVKGWKKLFGVVKDSL D---EQEVFDLSRRYFKKILQ-GPNQSIPLEIVGSVFSVVSRLTTVKEWKKLLELVKKGC NNNNNHTAYKVAHKYYQNFMN-SGINKTPKELLPAIFNVTMNKTSMKEYKKVLELVKNAT RLVE---VQSICNKYFKNILQ-GPTNAIPIELVGSIFTVVAYHCSVKDWKKLFELSRHVG IGLGILKFQDISRKMFKNFIN-PNSNKTPMELLPSIFNLTMRQANQKEYKQILQLVKNSN TSSTGEAAYKAAHKYYQNFMN-SGINKTPKEILPAVFNVTMSKASMKEYKKVLELVKKTN ------------------------------------------------------------ LNIANKEAYTVCHKYYQNFMN-SGINKTPRELLPSVMNVSMSKGSMKEYKRVLELVKNTN LASASKESQSVCKKIFKSFFN-SGVSNIPKELFTSMFNVTMMNANMNEYKQILNLVKKSN VYRSDFQ--EVGKKLFKNFVN-SGINKTPKQLATSMFNTMIYNAPQKDYKRVLEFVKETD R---NPDSTSLCRRIFRLLMN--PKPGVPKELLSAVFNLTMAVANQKEYKQILSMVKATN D---DSKMYGIAEQYCKKLLQ-GPSNSIHNDMVGSVISVISTKMSMKQYKQIISLTSNNA ------------------------------------------------------------ SVIIQNIAIENLACSRNEEIIRKVLNFVAT-NIES-NGVSRALYGLHNIEQVRDVAWQWL SIDIQNMALENLAFNTNEELIKKTLNFILT-NITS-TSVENALFGLNYNKLVRDVCWEWF ISSIQNSAIESLGFCLDLDIVKKILNFVTS-NIES-EGMELALFGFNYNPVVRELIWKWF YYPEGEQGKRLFGRNNDEELVKKTLNFIDG-TIEN-EPAIQIMQGLANSPAKIELVWDWF AMLIQNGAIESLGFCLDSDIVKKTLNFITS-NIES-EGMELALFGFNYNPVVRETIWEWY ------------------------------------------------------------ ATLIQNGAIESLGFCLDSDIVKKILNFVTS-NIES-DAMELALFGFNYNPIVREAIWKWY ATLIQNGAIESLGFCLDSDIVKKILNFITS-NIES-DGMELALFGFNYNPIVRDTIWKWY ------------------------------------------------------------ ALELQNVALANLSFARNEDLIKKTLNFVST-NIDA-TGIDMALFGMNYNKQVRDLVWEWY PVVLQNYAIENLGFSLHVELIKKVLNFVTT-NIDS-TSVELALFGLNYNVTVKDLVWNWF QQDLQTLSLTSLGSAADFELVNKTLNFVNN-NIDS-KLIELGLIGFTF-TQIIDTVFHWF VKDIQNAALETLGFSRTTGLVQKVLNFVLT-NIDM-TGCERALFGMSFNCSVRDMTWEWF SLNNSNSSIEQLSFAENEDLLSKSLNFVMT-NINS-KLIELALIGFQF-KQDILKLWHWY QQDLQTLSLTSLGSGADVELVNKTLNFVNN-NIDS-KLIELGLIGFTF-TRVIDLVFHWF ------------------------------------------------------------ QQELQTMSLTSLSFVSERELVNKTLNFINN-NIDS-KLIELGLIGFTYSNKHNEVVFNWF IQDLQTAAVSSLSFTTKPELLSKTLHFVNN-NIDS-KLIEFALIGFKYHTVIKDIIWGWY NLDLQTTAVSSLSFVHKDDLLHKTLNFVMT-NIDA-KMIELGLIGFQY-KQDKLKLFQWY VSELQTVAVSSLSFCESEELLAKSLNFTMT-NIDS-KLIELSLLGFQFKPHHRLKIFEWY MSHIYLGEPQSVGYSRNYEIVKKILHYVND-HISTIAHIDKMLLGVCNNVPIHEMLWEWF ------------------------------------------------------------ ESNYDLWARKAMREGSSKELDGIILYIFEMFRDSEG--KVDKFIL-RKEELLKIHLAQIW ELNYDLWGRKSLREGAKKTLVHISYVIFQMWMDNPE--KVDEFVT-KKNATYTLGTAQIW TDNFDQWARKATRKGTHKVLRSISLVIFQMFVADEP-ERIEKFINKEKLQNL-LSLDDVW VSHFHQWLRRSQKPKI-SIIVESISFSVFQLVQVSHSDDLRSFIE-SEK-------DQVK MGNFDQWARKATRKGTHKALRSISLIIFQMFVADEP-QKIEKFINKEKLQSL-LSLDDIW ------------------------------------LEHIA------------------- TDNFDQWARKATRKGTHKALRSISLIIFQMFAADEP-QRIEKFINKEKLQNL-LSLDDVW VDNFDQWARKATRKGTHKALRSISLIIFQMFVADEP-QKIEKFIN-LEKEKLMLSLDDIW ------------------------------------------------------------ MLNFPNWARKSLRQGAKKTFDSISMVIFQMWCDQPE--KIDMYVT-TQTAKFLLRLHEIW SLHYDQWAGKSLREGSKKSLTNISMVVFQMFVDTPE--KIDTFAVQSKFGKV-IGTQDVW KLNYDNWIMRSLRKGSGITIQNIMKMIIMKMMVNNEKLKLNEFIQ-LKLKNLNHGLKELV NLHYDQWARSSLREGTRNTLMAISVIVFEMWVDSPE--KIDTFVT-MKQSLFKLMIQEVW KLHYDQWTLKSLRKGSAITMNNISKIVLGDLMQYHSLVSMKEEFI-KEKHGL-KDLVQNI KLNYDNWIMRSLRKGSGITTQNIMKMIIMKMMSNNEKLRLNEFIQLKTLHGL-KELVDDW ------------------------------------------------------------ KLNYDNWIMRSLRKGSGITVKNIVKIMLKIMSNNKEKFKMDEFVESKTLHGL-KNLVDTW KVNYDQWVKRSLRKGSGVTVGNITRLVLGEVMQYKH-EDAEKFVA-QKSKELPHQLSERW KLHYDQWVLRSLRKGSGITVSNISKMVLGTIMQFDPLVELREKFV-KDKHGLQELLEAVQ NLHYDQWAKKSLRKGSASTMKNMDLIILGDIMQYDKILKRKRFVEEKLAKLSEHGLKDIM TDNWNN-KWNKTKNEYQSGITNVSVMVLQSVLPHSG-SQVSQYVSERPN---DTFLQNAY ------------------------------------------------------------ LTVKETTSSNKIIAGSVKALL-----------MGSIK---SQSTKRVVTPEVFADQQARN TAVKASESSKMNIYKGILGF------------MAPKKRSKKQNGTREVRSEVFEDSIAKN TSVQQDEVSRKTISKMLTTIM-----------MAPKKPSNRQTLRREVAPEVFQDSQARN DKLDLEGIWVDSAAISRLKLYEDSNSL-----MAIKKSSKKGNVRREVAPEVFQDSQARN ASVQQDEESRKTIRRDLASLV-----------MAPKKPSKRQNLRREVAPEVFQDSQARN --------------------------------MAPKKPSKRQTLRREIAPEVFQDSQARN ASVQQDEESRKTIRRDLSHLV-----------MAPKKPSNRQTLRREVAPEVFQDSQARN ASVQQDEVSRKTIRRDFTSLV-----------MAPKKPSTRQTLRREVAPEVLQDSQARN ------------------------------------------------------------ ALVKQNEESKVTIYQGILGF------------MAGKKRAKTQNRTREVTSEVFQDSQARN QMVKDGEASRMKIYQGILGF------------MAPKKRASKQNQKRDVEPEVFQDSQARN DDWYLENKENIRIGTFYNDLCDHICQ------MAPRKRNKTQNKTRTVDSEVFSDSAAKN ASVKDSQYSKMKIYEGILGF------------MASKKRSKKQNGTREVSSEVFQDSEARN DVANIEKQAIGMFYNDLINNLP----------MAPRKRSKVQNKTRTVESEVGSDSAARN HLENEESVRIGSFYNDLCDHICLK--------MAPRKRNKTQNKTRTVDSEVFSDSAAKN --------------------------------MAPRKRNKTQNKTRENESEVFLDSAARN ELESEECFKIASFYDGLCDEI-----------MAPRKRNKSQNGTRSIEPEVYSDSRAMN EAVEEEN----AERRAIASYYEDVQFSM----MAVRKRRQSQNKTRTIESEVTSDSQARN DENEEKVLIGGYYDDLVLQVLRA---------MAPRKRSKTQNKTRANESEVFSDASARN EEIEAQNEEK-KIIGKYYDRLEKEVFE-----MATRKRNKTQNQKRNVESEVFTDSAARN KIVSKSSI------------------------MAVKKSSKGQQTRREVRPEVFQDKQARN ------------------------------------------------------------ QLANAPNLTEKSERRKANKLQVKKEQARARLYG-KKKKEYSEKDLDLPSLNKAVNPGVKL QMANVPKMTEKSDTKKPTKLQVKKDNFKARLYGSQKKKEYTEKELNIPTLNRAIVPGVKI QLANVPKLTEKSAQRKPTRTKVRKEQSLARLYGPKKDKKYSEKDLDIPTLNRAIVPGVKI QLANAPVEAEKSRLRRGTKLQVSKEQAKARLYGAKKNPSINEKDLDIPTLNRAIIPGVKI QLANVPHLTEKSAQRKPSKTKVKKEQSLARLYGAKKDKKYSEKDLNIPTLNRAIVPGVKI QLANVPHLTEKSVHRKPSKTKVRKEQSLARLYGPKKDKKFSEKDLDIPTLNRAIVPGVKI QLANVPQLTEKSTRRKPSKTKVKKEQSLARLYGAKKDKKYSEKELDIPTLNRAIVPGVKI QLANVPHLTEKSAQRKPSKTKVKKEQSLARLYGAKKDKKYSEKDLDIPTLNRAIVPGVKI ------------------------------------------------------------ QLANAPKV-EKPSARKATKRQVKKEQAVVRLYGTRK-KEYSEKELNIPTLNRAIVPGVKI QMANVPKLTEKSAVRKPSRLQVKKEQAKARLYGSQKKKEYSEKELNIPTLNRAIVPGVKI LLADQPKLTPKSKVKKISKLALKKQQAKIRLYGAKNGKEYREDQLNIPTLNKAIVPGVKA RLGSAPKMTEKSATRKPSKLKVSKEQASARLYGSKNKKVYSEKELNIPSLNRAIIPGIKI LLMSQPKLTPKSIVKAPSKAAVKKQQAKIRLYGARSGKEYREDQLDIPALNKAITPGVKA LLADQPKLTPKSKVKKISKLALKKQQAKIRLYGAKNGKEYREDQLDIPTLNKAIVPGVKA LLENQPKLAAKSKVKKLSKLQVKKQQAKIRLYGAKNGKEYREEQLSIPDLNKAIVPGVKA LLEDQPKQKQKSTVKKMSKSAVKKQQAKIRLYGAKNGKDYREDQLNIPTLNRAIVPGVKA LLANQPKLTAKAKVKKPSKKNVKKEQARIRLYGAKNGKEYREDQLEIPNLNRAIVPGVKA LMANQPKLTEKSKVKKLSKRVVKKQQAKIRLYGAKNGKEYREDQLDIPTLNKAIIPGVRA LLENQPKLTPKSKVKKPSKLAVKKQQAKVRLYGAKNGREYKESELQIPVLNKAVVPGVKA QLANVPQLTEKSAHKKPNKLQVSKGQFKARLYGTKK-KDYTEKELDIPTLNKAVIPGVKI ------------------------------------------------------------ RRGKKGKKFIDDHDSLTLHRLIKTIGDKYDDITESKLEKDRRLEVIRELKRQEIERKEAA KKGKKGKKFIGDHDLIALNRLIKTIGDKNDEITESKLEKTRRLEEIRDLKRQEMERKETE RRGKKGKKFIADDDSLTLNRLIKTIGDKYDDIAESKLEKARRLEEIRELKRKEIERKEAL KRGKKGKKFIADNDSLTLNRLIKTIGDKYDDLTESKLEKARRLEEIRELKRKEMERKEDD RRGKKGKKFIADNDTLTLNRLITTIGDKYDDIAESKLEKARRLEEIRELKRKEIERKEAL RRGKKGKKFIADDDSLALNRLIKTIGDKYDDIAESKLEKARRLEEIRELKRKEIERKEAL RRGKKGKKFIDDDDTLTLNRLIKTIGDKYDDIAESKLEKARRLEEIRELKRKEIERKEAL RRGKKGKKFIADDDTLTLNRLIKTIGDKYDDIAESKLEKARRLEEIRELKRKEIERKEAL ------------------------------------------------------------ KTGKKGKKFVDDHDLLTLNRLIKTIGDKNDEVTESKLEKAKRLEEIRELKKQELERKEQA KRGKKGKKFVGDHDLITLNRLIKTIGDKNDEITESKLEKARRLEEIRDLKKQEIERKEEA KRGKKGKKFVDDNDTLTMNRLVKSINDKYDQVNESKLEKSRRLEEIRDLKRQEIERKEQQ KRGKKGKKFIGDHDTLLYNRLISTIGDKDEQLTESKLEKARRLEEIRELKRQEMERKEEA KKGKKGKKFVEDNDALTLNRLVKSINDKYDQANESKLEKSRRLDEIRELKKQELERKEEQ KRGKKGKKFVDDNDTLTLNRLVKSINDKYDQVNESKLEKSRRLEEIRDLKRQEIERKEQL KRGKKGKKFVDDNDSLTLNRLVKSINDKYDQVNESKLEKSRRLEEIRELKRQEMERKEQM KRGKKGKKFVADNDSLTLNRLVKSINDKYDQVNESKLEKARRLEEIRELKRQEIERKEQE KRGKKGKKFVDDHDSLKLNLLIKSINDKYDQTNESKLEKSRRLEEIRELKRKEMEQKEQE KKGKKGKKFVDDNDTLTLSRLVKSINDKYDVVNESKLEKSRRLEELRELKKKEIERKEQQ KKGKKGKVFVDDNDNLTMERLVKSINDKYDKVNESKLEKSRRLEEIREVKRREMEKKEEQ KRGKKGKKFIDDHDTLALNRLIKTIGDKYDDITESKLEKARRLEEIREIKRKEIEMKESL ------------------------------------------------------------ KQSQLEEKKDELKKKSSIARSMRRKNRRDQER-DLHTTVQRKKKSVSFAMSQYFGKTISL KKEQLEGKKDEIKKKASVARTIRRKTKRQELKQETLAAIKKK-KSVSFAMSQYIGKTIAL KQDKLEEKKDEIKKKSSVARTVRRKNKRDMSKSEAGPSKEKKVKKVSFAMSQYIGKTISL KKDKLEEKKDELKKSASAARSLRRKNKRDIARVSREELEKKKKKKVSFAMSEYIGKTISL KQDKLEEKKDEIKKKSSVARTIRRKNKRDMLKSEAKASEGRKVKKVSFAMSQYIGKTISL KQDKLEGKKDEIKKSASVARTIRRKNKRNILKSEATASKEKRLKKVSFAMSQYIGKTISL KQDKLQEKKDEIKKKSSVARTIPRKNKPDIVTMNLKPAKKRTRTAKNFDMSQYIGKTISL KQDKLEEKKDEIKKKSSVARTIRRKNKRDMLKSEAKASEGKKVKKVSFAMSQYIGKTISL ------------------------------------------------------------ KKEKLDDKMDELKRKASVARTLRRKNKRHEKKLED---VPKSSKKVSFAMSQYIGKTISL KKNKLDEKKVEIKHKASVARTLRRKNKRDEGRSESETIKPKGKKTVSFAMAQYIGKTISL KKDKLEGKKDELRSKASVARSTRRKNAKARRADEESQESPKKKKKVSFVMSQYIGKTISL KKDKLDVKKEELKKKASVARTLRRKTKRDLYKEDKKSAGNAKRKTVSFVMAQYIGKTISL KENKLEGKKNEVKSKASLARANRRKSAKSQKNEESKAASNKGKKSVSFAMSQYIGKTISL KKDKLEGKKDELRSKASVARSNRRKNAKARRAEDESQELPKNKKKVSFVMSQYIGKTISL KKDKLDGKKDELRSKASVARAARRKNAKARKADEVDEGTVPKKKKVSFAMSEYIGKTISL KIDKLEGKKKELRSKASVARSARRKNAKARRAEDDADEPKHKKKKVSFAMSQYIGKTISL KTNKLENKKNEIRSKANIARAARRKNSRLSKKGDAQPEEPKKKKSVSFAMSQYIGKTISL KMDKLEGKKSELKNRASVARSNRRKNAKAAKKIEDEETPRKKTKSVSFAMSQYIGKTISL KKNKLDDKKKELKNKASVARANRRKNAKEAAKEA----DEPRKKKVSFAMSQYIGKTISL KNDKLEEKKNEIRSKASLARSMRRKNRRDTVRADVEEKNKKPKKKVSFAMSQYIGKTISL ------------------------------------------------------------ ISVTDNRYVGLLQNIDSEKGTVTLNEVRCFGTEGRKNWGPDEVYPNPTVYQSVKFNGNDV ISNTDNRYVGLLESIDSEKGVVTLRQVRCFGTEGRKGWGPEEIYPNPNIYDTVPFNGNDV VSVTDNRYVGLLEDIDSEKGTVTLREVRCFGTEGRKNWGPEEIYPNPTVYNSVKFNGSEV ISVTDNRYVGLLEGIDSDKGTVTLNEVRCFGTEGRKNWGPDEIYPQNTVYNSVKFNGNEV ISVTDNRYVGLLEDIDSEKGTVTLKEVRCFGTEGRKNWGPEEIYPNPTVYNSVKFNGSEV VSVTDNRYVGLLENIDSEKGTVTLKEVRCFGTEGRKNWGPEEIYPNPTVYNSVKFNGSEV ISVTDNRYVGLLEDIDSEKGTVTLKEVRCFGTEGRKNWGPEEIYPNPTVYNSVKFNGSEV ISVTDNRYVGLLEDIDSEKGTVTLKEVRCFGTEGRKNWGPEEIYPNPAVYNSVKFNGSEV ------------------------------------------------------------ VSNNDNRYVGLLESIDSEQGVVTLINVRCFGTEGRRGGGADEVYPNPAVYNSVVFNGNDV ISVTENRYVGLLEGIDSERGVVTLNQVRCFGTEGRKNWGPQEVYPNPTVYDTVTFNGNDV ISNKGLRYVGLLENINADDATVALKSVRLFGTEGRAMGQPNEVPPGVDVYDYVVFRGSDV ISVTENRYVGLLEGIDSEKGVVTLNRVRCFGTEGRKQWGPQEIYPNPTVYETVTFNGNDV ISNKGLRYVGLLDNINADDATVALKSVRSFGTEGRASGNANEVHPGTDVYDYVVFRGSDV ISNKGLRYVGLLENINADDATVALKSVRLFGTEGRAMGQPNEVPPGVDIYDYVVFRGSDV ISNKGLRYVGLLDNINGNDATVALKSVRMFGTEGRQMGQPHEVPPGTDVYDYVVFRGNDV ISNKGLRYVGLLENINADDATVALKSVRLFGTEGRAMGQPHEVSPGVDVYDYVVFRGSDV ISNKGLRYVGVLENINAEDATLALSQVRSLGTEGRQVGQPQEVLPGADVYEHVVFRGSDV ISNKGLRYVGLLDNINADDATVALKSVRLFGTEGRAAGTPNEVMPGSDVYDYVVFRGSDV ISNKGVKYVGLLDNINADDATVALKSVRSFGTEGRAAGNPSEIMPRPEIYEYVVFRGSDV ISITDNRYVGLLEEIDSEKGTVTLRDVRCFGTEGRKNWGPEEIYPNPKVYNSVKFNGNEV ------------------------------------------------------------ KDLSILEVKLHEVQPV---MPPP-----HVLQQQQQQQVEPNSNQTPSDQAPVPQQQAQQ KDLNILDVPLEQVQPV---LPPQ-----VSGQPPAPLANANGPN---------------- KDLSILDANINDIQPVVPQMPPA-----TQASPSQQAQSPHQAQAQAPAPAQAPAQPQAT KDLSILEVKIEDVHPV---LPPT-----ATAVPMMPMQEQPRSQ---------APPSQQS KDLSILDANINDIQPVVPQMPP------ASQFPPQQAQSPPQAQ----AQAHVQTNPQVP KDLSILDANINDIQPVVPQVPPT-----SQLSSSQQAQSPQEAQ----------ASPQAQ KDLSILDANINDIQPVVPQMPPA-----SQFSSLQQVQSSPQTQ----TQVQAHSPPQGA KDLSILDANINDIQPVVPQMPP------ASQFPPQQAQSSPPAQ--------VQAQSQAP ------------------------------------------------------------ KVLNILGCALEKVQPA---LPPQ------------------------------------- KDLNILDVKLEDVQPVL---PPQ-----VMMQPQQQ------------------------ KDLSVLDTPIDEVKPNIY-RPPQQQQQQYYSGPTSTSSQNGTPQASQSYGQTSSSAPTQA KDLNILDIGLDEVQPV---LPPPQVVMQQQLQQEQQQQQQPGPQHQQENPSQERHHHQRP KDLTVLDTPIDQVKPEPYTAPAPGGYPAYQQQPQTQTQQKPQKA--PAPSTTSAAPAKAA KDLSVLDTPIDEVKPNIYR-PPPQQPQQYYSGPTSTSSQNGTPQGSQSYKQASSSAPTQA KDLSVLDIPIEEVKPVIYHQPPAPTMPPIPPYPQQQQQSQPQTPQSPATSLGYSQQPRAA KDLSVLDTPIDEVKPNIY-RPPQQQQQQYYSGPPSTTTANGAPQTSAQSPVQSSVSNVPA KDLSVIDVPVDQVGAHP-----------GEASPQERSQSREQEHREPTHGSRAGPTPSAA KDLSVLDTPIDQVKPEPY-IPAPQSTAGYYQQQPTQTSAPSGALAFGPSGVSDATPAQAV KDLSVLDVPIDQVRPEPQQPPPPKTTSGMTAAPPTTTSVPSGAPRVAENSRSGPQPGAIG KDLNILDAKLEDVQPV---MPPT--------APNAQTSQPAQ--------------PAVA ------------------------------------------------------------ APKPDVPAAVSGYGVYAPSASDSTAVGT--ATFSDSIASSTQSGNANSDDFNKSSQ---G -----VPAAVAGYGVYAPDKDQQQVPQ---QHQQKQQQQRQQTRQQPVTEKKVPNQQ--Q KPESNVPAAVAGYGVYTPSSTE--------ASTAKKDNAIPQNRDERKDGEHEQRYQ--R APPQQVPSVVAGYGAYAPPPGSAASAPTATTTQPQQTTAFSSSTGESQGEIQPPHDRGNR KPESNVPAAVAGYGVYTPTSTETATASMNDKSTPQDTNVNSQSRERGKNGENEPKYQRNK KPVTNVPAAVAGYGVYTPTSTESTAVNKNDNAIPRDVNKNSQSRDERKDGGNEQKYQRNK KPDSNVPAAVTGYGVYTPTSTETATTNIGDNTISEDVSVNSQSRNKRTDSEHEQRYQRNK KPESNVPAAVAGYGVYTPTSTETATANMNDKSLSQDANVNSQSRERGKNGENEQKYQRNK ------------------------------------------------------------ -----VPAAVAGYGVYAPAASEGAAP----AAAPATAAAPAAAAGAV------------A -----VPPAMADYGVYAPSTEEKA------EEPAPPVRKQEPKNDEG------------- SPAQAVPAQPVQTSAPEASTSCQQPTKTVKEEQATKTVADDQPADAQPGSAPQPTATNPS QQQQNVPAAMAGYGVYAPSTAIAQSSPAAEASQPKPLPSKKNQKPR-------------E SAPTQTSAPKQRAQKPSETQTQPQAPTPSQQQQLQPQATPTSARTEETGKEENASPA--Q SPAQAAPAQPVQTSAPEASTSYQQPTKTVNEEAATKTVTNDQPADAQPGSVP-------Q PTSSAAPEASAAFQKPTPTKTSDTAQTPTREPQSTSANANNDNYQSGSGSVEQPQPVSRP ASPGQVAQAPVETGIPEAPQVQNPAPTRTIDEEPLTKTVSENKPADA------------Q PAAAQAPSQTSAQA---PAQTGAAPASG--VSGARPTAVS-------GGAARPQPSATAA TAPSAYAEPEPRRTKPEPSRSQAQQPSSIYQKQAQPVDRPNPDEKTSVFDSEPLQAKPAD RPPVQTAAPTATSTAPTPSASSTQPTRT--TQTSVPGSRPEPSKPSGTTEVPQP-----Q APQ--VPAAMAGYGVYQPSEESQATPSVGQEERPKAAANNDSKQYQNQNQHQHQHQHQHQ ------------------------------------------------------------ SRQQHRKPQHAAPHKVEIPDSDFDFATNNAKFSKT----EEEVLEEKPELPDQDKFYDKK QKSAAPAAPVAAVAPSAVPDSEFDFESNNAKFQNAEKPRESDIEQEKQTSKTDEIFYDKK NKSTNRAPQSNRNHKVEIPNEDFDFQSNNAKFTKELEKEQELESAADKEDESDEAFYNKK ERSNQNRRRGSHSRKIEIPKSDFDFQSSNAKFAKEEHVEGQETALAQNENATPDTFYNKK NRSSNRPPQSNRNFKVDIPNEDFDFQSNNAKFTKGVEKEKELESAVHKQDESDEQFYNKK NRSTNRPPQLNRNFKVEIPNEDFDFQSNNAKFTKELEREQVLESAAHRQDESDEACYNKT NRLTNRPPQSNRNFKVEIPNEDFDFESNNAKFTKEAEKEQELEATARKQDESDEAFYNKK NRSTNRPPQSNRNFKVDIPNEDFDFQSNNAKFTKGVEKEQELESASNKQDESDEPFYNKK ------------------------------------------------------------ AGAAGRAG------------ADFDFEQSNARFSKG----GTAGAEAPAAAAGEEVFYDKK --------VRRPSRKTEIPNEDFDFESNNAKFNKPEDEEEQEEEQNTEDDSSEEVFYDKK NQSQQQQQQPRKGSKVEIPTEEFDFEQANAKFSKE----------LEQERELEHAGYNKS PIAAKQAPSKPETRRVDIPTEDFDFQSNNSKLEKG----VHPGAARNDRQEGDEPFYNKT PRPQEHPQQKNVSKVSNVPETAFDFESANAKFSRD----------IDSEKDAEQPMYNKQ PTATKQQQQARKGSKVDIPTEEFDFEQANAKFSKE----------LEQERELEHTGYNKS SASSENNRNSSTSTKPVAFDEDFDFEKANAQFRKE---------LEEANEEENKPTYDKK PGSVPQPAKPRRESKLDIPPEEFDFEQANAKFSKE----------LEQERELEHTGYNKS DRASATQTSENAQPGFDTA---FDFESANARFEKE--------------HAEHKPVYSKE NRRTSKAP--------EIPNDEFDFESANAKFTKE----------LEHEKELEHSAYNKQ PGSRPQPPQPSSGPQMD---GDFDFASASAAFERE-------------RTKEGAPSYQKS HQYQNQRRQQRPPQKIEIPKEDFDFQSNNAKFTKEEAAAEELTNENENSEETQEAFYNKK ------------------------------------------------------------ SSFFDSISTSAEENTNMRWSEEKELNLDTFGQASVRPRFNGRG-GRGRGRGRGR----GR SSFFDSISSSAENSSSAKWEEERQVNLDTFGQARPRN--NGRGGFRGRGGYRG-----NR SSFFDTISTSTETNTNMRWQEEKVLNVDTFGQASARPRFHSRGRGRGRGNYRGNRGNRGR SSFFDSISTSTEANTNMRWQEEKVLNLDTFGQTSARPNFGGRGRGRGRGG-RG-----GR SSFFDTISTSTETNTNMRWQEEKMLNVDTFGQASARPRFHSRGLGRGRGNYRGNRGNRGR SSFFDTISTSTETNTNMRWQEEKVLNVDTFGQASARPRFHSRGRGRGRGNFRGNR---GR SSFFDTISTSTETNTNMRWQEEKMLNVDTFGQASARPRFHSRGRGRGHGSFRGNRGGRGR SSFFDTISTSTETNTNMRWQEEKMLNVDTFGQASARPRFHSRGRGRGRGNFRGNRGNRGR ------------------------------------------------------------ SSFFDSISTSTETNTNMRWKDERQLNMDTFGQASARPR-NGRGWFRGRGG-RG-----GR SSFFDTISTSTETNTNMRWQEERQLNMDTFGQVSARPR-----RGRG-GGFRGGRGRNGR SSFFDNISSSTDERTNMRWHEERNLNMDTFGEASLQRG-RGRGRGRGRGNWRGRGNYRGR SSFFDTISTSTETNTNMRWQEERQLNLDTFGQASVGNR-------RGRGGFRGRGGR-GR SSFFDNISSSADEKNTMRWAEEKNLNLDTFGESSVNNR--GRGRGRGRGNWRG-----GR SSFFDNISSSTDERTNMRWHEERNLNMDTFGEASLQRG-RGRGRGRGRGNWRGRGNY-GR SSFFDTISSSANNSGNMRWSEEKNLNMDTFGETGSR---NSRG-GRGRGGRGGRG---SR SSFFDNISSSTEERTNMRWSEERNLNMDTFGEASLQRGGGRGGRGRGRGNWRGRGGNRGR KGFFDSMSV--NEGNGMRWNEERSLNMDTFGQASVRRG-RGNFRGRGRGNFRGRG--RGR SSFFDNISSSTEERGSMRWAEEKSLNLDTFGEASLRGR--GRGRGRGRGGRGGRG---GR S-FFDSLTS--NDHQSLRWAEEKSLNMDTFGEASVNNSRRGRGRGRGRGGWRGRGR--GR SSFFDSISTSTETNTNMTWTEEKEMNLDTFGQMSARPRFSNRGNFRGRGRGRGRGGRRGR ------------------------------------------------------------ GRGRG---GRGSFNNYGHDNYQNAHNEKLEF--------------MKLEKSIKYG----- GGNRGGFRGNRNA---------KPPVHDVES----------------------------- GGQRGGYQNRNNYQNNRGGYQNSQPPSNVEF----------------------------- GRGRGGRGGRGGYNQHQGDYQNNDTTHQVEF----------------MIRILQGM----- GGQRGNYQNRNNYQNDSGAYQNSQPPSNVEF----------------------------- GGQRGNYQNRNSYQNTRGGFQNSQPSSNVEF----------------------------- GGHRGNYQNRNSYQNNGGGFQNSQSSSNVEF----------------------------- GGQRGNYQNRNNYQNNGAGFQDSQPPSNVEF----------------------------- ------------------------------------------------------------ GRGRGGRRGGGG----------GARPAKVDF----------------MLASKARS----- GG-RGGRGSRRG-NNFRNNFGN---DEKIEF----------------MLRFCITR----- GGWRGGNSNRGRN---------SDYNTKPEW--------MLRGLIKPFLPVTQL------ GG-RG---GRGGFRKNENFSRNDSTSERIEF----------------MLKNQL------- GNWRGGRGGRGGNRSN------NDYNSKPEW----------------------------- GGWRGGSSNRGRN---------SDYNTKPEW--------MLRGLIKPFFPVAQL------ GNWRGGRGGTGS-GSSGGNWRGGRREPKPEWTAFSLFADLFRSTIALYLTMRKIP----- GNWRGGNNNRGRN---------SDYNTKPEW--------MFRAILNEILPSRVEP----- DR--------------------GKPEPKPEW--------MSFLQRFPYLHNRSSWQRCSR GFWRGGR-GRGGQRNN------NDYNTKPEW-------MMIRHLAASYLVPIRPS----- GR--------------------GKPEPKPEW---------------MYICKVSSYGKVIR GRGRGGYNNRDNYNQSGSNNYNGSYRSNVEF----------------------------- ------------------------------------------------------------ ----RAMNKARH---LCLTGIGNPEPSYKGTRHNVGLTVLDLLIKQLVPRDQHVF---RR ------MSAQKL---LCLSALGNPEPLYRSTRHNAGVIMLRMLKNEFCPDAVLKTSN-VS ------MSGKWR---LILTGIGNPEPQYARTRHNVGLYMLELMRKRLGLQDRAYSPVPHT ----PTLKRAFH---TCLTGIGNPEPTYRDTRHNVGLFVLDGIKDYLVGSQVRYLPCSKV ------MSGKWR---LVLTGIGNPEPQYAGTRHNVGLYMLELLRKRLGLQGRTYSPVPNT ------MCGKWR---LILTGIGNPEPQYAGTRHNVGLYMLELLRKRLGLQDRTYSPVPHT ------MCGKWK---LVLTGIGNPEPQYAGTRHNVGLYMLELLRRRFGLQDRTYSPVPNT ------MCRKWR---LVLTGIGNPEPQYAGTRHNVGLYMLELLRKRLGLQDRTYSPVPNT ------------------------------------------------------------ ----APQRRTLH---LCLTGLGNPEPQYRNTRHNAGLILLDLLKAHYAPGKPWMPCTVPR ----LNARRSVS---VCITGLGNPEPAYANTRHNAGLTMLDMLKDELAPGKPFVSSKTNK ----PLSCSRRY---LFIASIGNPEPQYANTRHNAGHRLMNQLIDVYWKDHV------YK ----LRSQRTLS---TCFTGIGNPEPQYAFSRHNAGLMMLDLLKERLQPISKPYVVCNAS ---TLEPEKPPF---LMIASIGNPEPQYQGTRHNVGHWALDELITNHWTSFNQFQNHKIP ----HLYFSRRY---LFIASIGNPEPQYANTRHNAGHRLMNQLIDVYWKDHL------YK ----SFANDTKY---IFIASIGNPEPSYAGTRHNVGHRVMDHITNNYWKDHV------YK ----VIQSSKRT---LFIASIGNPEPEYQGTRHNAGHRLMNSLIEVHWKDHV------YK F---FSSKSASS---VLVVGIGNPTPTYNGTRHSVGHYILDKMIEEYWTNFGSFKPMALN ----TVSQSRRL---LFIASIGNPEPKYEGTKHNIGHRMLDQLVDIYWKDHL------VK IGYRLLSTRSGG---VLVVSIGNPEPQYKDTRHNVGHWIINELHRNNVPIEYGPWADDKT ---------------MILFGIGNPV-KYKGTRHNVGKYIIEQLRRELCPNIE------YK ------------------------------------------------------------ EGK-VHVLR----TPTITFIRSDIGFMNLSGRSVVPMWQKLYTDH------TDYAVIHDE PH--IQYCHEP--RLNLLMLFNKSQFMNLSGHAMIPVWRKLPHD-------ALHVVLHDE GGK-VHYIE----GEHCTLLKSDGQYMNLSGEQVCKVWARYAKYQ------ARHVVLHDE SKVHAQYLTV---PPDLILLRSDGSYMNVSGENVIPVWRRIESQSSSP---LKHIVIHDD GGK-VHYIE----DEHCTILRSDGQYMNLSGEQVCKVWARYAKYQ------ARHVVIHDE GGK-VHYIE----GEHCTLLRSDGQYMNLSGEQVCKVWARYAKHQ------ARHVVIHDE GGK-IHYIE----GEHCTLLRSDGQYMNLSGEQVCKVWARYAKHQ------VRHVVIHDE GGK-VHYIE----DEHCTILRSDGQYMNLSGEQVCKVWARYAKYQ------AQHVVIHDE ------------------------------------------------------------ VA--ASYCHAS--RHDLLLLRSDGAFMNRSGQNVVPLWQRIGG--------ATRVVVHDE L---VKYVQ----KDTLVMLRSDGNYINLSGENVVKLWNKLGKN-------VLHIVLHDE KG--PYYLSTK--YSNLVLFKSNDSLMNLQGLPISKHFGKHDQGK------SALVVLHDE NK--VKRCQ----IGQLLFLRADGDYINLSGKTVVPLWKKLGSN-------INHIVVHDE DGVYSTSRVED--LSDIFLFKSIYSFMNLQGAPVSKTWQKVSNYQKATRS-PALVVLHDE KG--LYYLSTK--YPNLVLFKSNDSLMNLQGLPISKHFTKQGYGK------SALVILHDE QG--PFYLSTK--YPNIVLFKSDSTFMNIQGRVIQKHFNQHPKG-------SQMLVLHDE KG--DYYLSSK--YPNLILYKSNDSLMNRQGRFLRRHIAHYKD--------TKLVVLHDE SS--FVYSKSQTALSNVLLAKTVSSYMNLSGTPVSKLWQKYHQQNLNSR--PAMVVLHDE DG--PYYRSTK--YSNIVLFKSNDSLMNLQGKAVSKHYRQFQKD-------SQLVILHDE FG--GEISTSS--DGNVVLARSIGSYMNTQGKPVSKITQRYGKD-------KTLLVVHDE KG--KRYCDGGDTSERLVLCRSVDTFMNHSGLSIKEYLRGRHGGAGSL---QRMVVVHDE ------------------------------------------------------------ LSLRTGALQLRQPQASLRGHNGLRDISAHWRHQ------YYKLAIGIDR-P--ESRDPQA LNIPIGNVQLRKPGTSFRGHNGLRDMIKMKGDD-----KFHKLGIGIDR-P--NSRDPRI LSVACGRVQLRAANASIRGHNGLRSLVQCSGGR----VPFARLAVGIGRDPGSHSRDPAS LEKPLGNVQLRGPGTSLRGHNGLKSIASKLGGK----NTFYKLSIGIGR-P--LSKDPKA LSVACGKVQLRAPSTSIRGHNGLRSLLKCSGGR----VPFAKLAIGIGREPGSRSRDPAS LGVACGKVQLRAASASIRGHNGLRSLVKCSGGR----VPFAKLAVGIGRDPGSNSRDPAS LSVECGKVQLRAAATSIRGHNGLRSLVKCSGGR----VPFAKLAVGIGRDPGCHSRDPAS LSVACGKVQLRAPSTSIRGHNGLRSLLKCSGGR----VPFAKLAVGIGREPGSHSRDPES ------------------------------------------------------------ LSLPLGKVQLRAPGRSPRGHNGLKSIIAA-GAQ----GTYYSLAVGIDR-P--ETRKPAA LSLPLGKVQLRTPGASVRGHNGLKSIVQYCGSD------FYRLAIGIGR-P--LQRDSHS LQVDLGKYQIRKPGTSSRGHNGLKSIDKYLKNR------YFKLGIGIGR-P---PA-SQS LSLGLGKVQLRKPGTSVRGHNGLKDITKLYGDG------FYRLAVGIGR-P--EERDPGS LQVPFGKFQIRKQLSSARGHNGLRSIDSLMGGG------YTKISIGIGK-P-----TAKD LQIHLGKYQIRKPGTSSRGHNGLKSIDKYLKNK------YFKFGIGIGR-P---PA-SQS LERPLGKFQLRQAGTSSRGHNGLKSIDGFCKS-------YQKLGIGIGK-P-----TSGS LQRDVGKFQIRGPGTSSRGHNGLKSIDKHVGGK------YTKLGIGIGR-P-----QTKS LQVPLGKIQIRRRNTSARGHNGLRSIDQAIGSN------YIKLAIGIGK-P---PQ-KTS LQVPVGKYQIRKPSTSPRGHNGLKSINQHLPNN------YTKVAIGIGR-P----SDKRH LQKDLGKLQLRGPGTSARGHNGLKSIDSAMGNK------YTKLSVGIGR-P---NKGQKE LELSIGKIKMRDGGSSNRGHNGLKSVYGEVGP-------VTKLGIGIGR-P---SRSDDD ------------------------------------------------------------ VADYVLSKVPQRDATYIENTTTSKALELLQRQFPYI------------------------ VADYVLANFTKGEMETLQYDSFQKAVEHVRKLLPH------------------------- VSRWVLGTLTPQEQHTLLTESEPAAWRALAQYVS-------------------------- VSDYVLGKFITQEMDILREKSLPLALNLLGL----------------------------- VSRWVLGALTPQELQTLLTQSEPAAWRALTQYIS-------------------------- VSRWVLGALLPQEQQALLTQSEPAAWRALNQYLS-------------------------- VSRWVLGALTPQEQQTLLTQSEPAAWRTLTQYLS-------------------------- VSRWVLGALTPQELQTLLTQSEPAAWRALTQYIS-------------------------- ------------------------------------------------------------ IADYVLSRFSRAELSQLEQDALPAALGHLNGLLGVVVT---------------------- VAEYVLERFTPQDLDILRQESFGKASKLVNNLLK-------------------------- VVHYVLKNFSSQELDVIDWEVLPKCVKDLENMVIKDLELQSGKEKINGI----------- VANYVLAKFKPSEQSIIGTVSLEKALEHLKTFIGENTGI--------------------- LSNYVLSPFTPLEQEVLTYDVMPQIVNVLQEMKDGKYIYDKQEPDPNQSKKKRQK----- VVQYVLNEFLVEDLKVIDWKVLPKCVKDLENMVIQDLKLQSGKDRVNDL----------- VSDYVLKKFDSQEIEELDLKVIPKVIKKLEEVIEVNLQSQVQVNNLLP------------ VVDYVMEEFQPQEAEILDWEVFPKCARELQKLVDEELKQMQKAEQEEVSEEKLDQ----- VSDFVLAKFSPVELETLAEQTMPKVAKAMAEFAKGQHIYETYDHSKK------------- VVDYVMSKFKDLELEELDFEVLPKCVKELEKLVEMDKEARKERVDKKVEVSV-------- VSDYVLSKFTTSERAELEK-VLEKASVLVSQVINDSINHK-------------------- VVEYVLSEMSETERRIIREETVPRVLMLLNDQLAARK----------------------- ------------------------------------------------------------ -------------------MAVQKILEITGERP--KLELP-------------------- -----------------MTTRYQRVLEINAKE---KISLA-------------------- ------------------------------------------------------------ ---------------------MNRIIDIEGTTK--EISLP-------------------- -----------------MLSRYNRVIEINGGNA--DISLP-------------------- -----------------MLSKYNRVIEIDGGSS--DISLP-------------------- -----------------MLSKYNRVIEIDGGNA--DISLP-------------------- -----------------MLSRYNRVIEIDGGNA--EISLP-------------------- ------------------------------------------------------------ ------------------MSRQPRILEFGAEE---KVSLP-------------------- ---------------MTQTNKYTRIIEVGSSEENTRVTLP-------------------- ---------------------------MNDTED--TIYIP-------------------- ----------------MSSNRYQKVIEINGAS---KISLP-------------------- --------------------------MASTEDD--STYIP-------------------- ---------------------------MNNTED--TVYIP-------------------- ----------------------------MTEQG--IINIP-------------------- --------------------------MSTIQDD--TVYIP-------------------- -------------------------------ME--DTYIP-------------------- ---------------------------MSEEDD--SVYIP-------------------- -----------------------------MSTD--DVHIP-------------------- -------------------MVVDRIISFDGEVE--DISFP-------------------- -----------------------MVLEIDNSYH----AAH-------------------- --------------IVN----FPPF---------------------------------KL --------------IVK----FPPF---------------------------------KL ------------------------------------------------------------ --------------IVK----FPPT---------------------------------PL --------------IVK----FPPF---------------------------------KL --------------IVN----FPPF---------------------------------KL --------------IVN----FPPF---------------------------------KL --------------IVK----FPPF---------------------------------KL ------------------------------------------------------------ --------------IVK----FPPF---------------------------------GL --------------IVK----FPPF---------------------------------KL --------------IPH----YPPF---------------------------------KL --------------IVK----FPPF---------------------------------KL --------------IPH----YPPF---------------------------------KL --------------IPH----YPPF---------------------------------KL --------------IPH----YPQF---------------------------------KL --------------IPH----YPPF---------------------------------KL --------------IPH----YPPF---------------------------------KL --------------IPH----YPPF---------------------------------KL --------------IPQ----YPPF---------------------------------EL --------------IVK----FPPI---------------------------------GL --------------IPT----YPSP---------------------------------EE RAWLIEK-------------------D--------------------------------- RAAMVEK-------------------D--------------------------------- ------------------------------------------------------------ TALLVEK-------------------D--------------------------------- RAQLIEK-------------------D--------------------------------- RAQLIEK-------------------D--------------------------------- RAQLIEK-------------------D--------------------------------- RAQLIEK-------------------D--------------------------------- ------------------------------------------------------------ RAALVEK-------------------D--------------------------------- RAAMVEK-------------------D--------------------------------- RSSLIDK-------------------D--------------------------------- RAAMVEK-------------------D--------------------------------- RSSLIDK-------------------D--------------------------------- RSSLIDK-------------------D--------------------------------- RSSLTDK-------------------D--------------------------------- RSSLIDK-------------------D--------------------------------- RSSLIDK-------------------D--------------------------------- RSSLIDK-------------------D--------------------------------- RSSLIDK-------------------D--------------------------------- RALLIEK-------------------D--------------------------------- KPLIPDQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------PVVWAHLLETYV ------------------------------------------------PVIWLHLLEVYV ------------------------------------------------------------ ------------------------------------------------PVVWAHLLSTYV ------------------------------------------------PVVWLHLIETYV ------------------------------------------------PVVWLHLLETYV ------------------------------------------------PVVWLHLVETYV ------------------------------------------------PVVWLHLLETYV ------------------------------------------------------------ ------------------------------------------------PVVWVQLLETYV ------------------------------------------------PVIWLHLLEVYV ------------------------------------------------PVIWVHLLEAYI ------------------------------------------------PVIWLHLIETYN ------------------------------------------------PVIWVHLLEAYI ------------------------------------------------PVIWVHLLEAYI ------------------------------------------------PVIWAHFLEAYI ------------------------------------------------PVIWVHLLEGYI ------------------------------------------------PVIWVHLLEGYI ------------------------------------------------PVIWVHLLEAYI ------------------------------------------------PVIWVHLLQAYN ------------------------------------------------PVVWAHILETYV --------------------------------------------------LWNLLIQGWI QYFK--FLN--------------------------------------------------- QHMS-YLL---------------------------------------------------- ------------------------------------------------------------ EYFE-FLL---------------------------------------------------- TYFE-YLM---------------------------------------------------- KYFE-YLM---------------------------------------------------- TYFE-YLM---------------------------------------------------- TYFE-YLM---------------------------------------------------- ------------------------------------------------------------ THLQ-YLM---------------------------------------------------- SYLQ-HLM---------------------------------------------------- HLMT-VLL---------------------------------------------------- RYFA-YLM---------------------------------------------------- QLFK-YLLN--------------------------------------------------- HLMT-VLL---------------------------------------------------- QLLD-YTL---------------------------------------------------- KLMQ-FLL---------------------------------------------------- QLCQ-VLL---------------------------------------------------- LLFN-LLL---------------------------------------------------- QLLQ-VLV---------------------------------------------------- AHLE-FIM---------------------------------------------------- RVAEQHLIR--------------------------------------------------- ------------------HGNNIEDLNEST------HDHLC----IFLR----------- ------------------HGDNLDFLSDET------IDHLC----IFVK----------- ------------------------------------------------------------ ------------------WDNNIEHLDEST------FDHLC----IFVR----------- ------------------QGANVELLDEST------LDHLR----LFLR----------- ------------------QGTNVELLDDST------LDHLR----LFLR----------- ------------------QGNNIELLDDST------LDHLR----LFLR----------- ------------------QGVNVELLDDST------LDHLR----LFLR----------- ------------------------------------------------------------ ------------------AQGRIDKIDGTT------HERLV----VFVQ----------- ------------------SNDRVNQLSDST------YEGLC----AFIK----------- -------------------DPETPKLNVKS------QQQLQ----LFLK----------- ------------------SEGNLEQIDDST------YENLC----LFVR----------- ------------------PDSHSQKLSVKS------QQQLQ----LFLK----------- -------------------DPETPKLTVKS------QKQLQ----LFLK----------- -------------------QDGIAKLTIKS------QQQLL----VFIR----------- -------------------DVNSPKLTIKS------QQQLQ----LFLK----------- --------------------SGKIKLNVKS------QQQFQ----LFLK----------- -------------------DSNAVKLNVKS------QQQLQ----LFLK----------- ------------------DPPESFKLSVRT------QQQLQ----YFVK----------- ------------------QGNNLERLSSST------MDSLL----IFLR----------- ------------------VSDDNQRVENAD------ILEIS----TWID----------- --TYLKEMAEEEGKLLSLG-A-------NSDVTKQLQL-------LR------------- --AYVHEMSEEEGKLLSLG-I-------NADVLKQLEL-------LR------------- ------------------------------------------------------------ --SYLKEMASNVGGLASLG-I-------NKEVDEQLGL-------LR------------- --TYLHEIADEEGKLLSLG-I-------NHDVSEQLYL-------LK------------- --TYLHEIADEEGKLLSLG-I-------NHDVSEQLQL-------LK------------- --TYLHEIADEEGKLLSLG-I-------NHDVSEQLRS-------LK------------- --TYLHEIADEEGKLLSLG-I-------NHDVSEQLYL-------LK------------- ------------------------------------------------------------ --AYLHEMAEEDGKVLSLG-M-------NMEVQRQLAA-------LR------------- --SYLHELAEEEGKLLSLG-M-------NTDVLEQLKL-------LR------------- --IFLFETCEEETKIFSLGAI-------NPDIKKNTSI-------LK------------- --SYLKELSDEEGKLLSLG-M-------NANVSEQLQI-------LR------------- --IFLFETSEETMKIFSLGAI-------NPDIKTNTAI-------LR------------- --VFLFETCEEESKIFSLGAI-------NPDIKKNTSI-------LK------------- --TYLKESYEETGKIFSLGAI-------NPDIQRNGEI-------LR------------- --NFLVETSEEESKIFSLGAI-------NPEIKTNTSI-------LK------------- --VYLAETSEETTRIFSLGAI-------NPEIRKNTAL-------LR------------- --VFLYETSEEKTKIFSLGAI-------NPDIRANTAT-------LR------------- --VFLSETSQEGSRIFSLGAI-------NPDIKANTAS-------LR------------- --SYLHEMANDKGIIQSLG-E-------NNDVTKELEL-------IR------------- --SYLKNTEEDQD-------A-------DPK--------------LN------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TWVFELIKK--------------------CGLMHF-----QLHGETI-- -----------AYVLQLIKS--------------------CGLLYL-----KLNTESL-- ------------------------------------------------------------ -----------RWIFHLITG--------------------CGLLHL-----QIYGETL-- -----------GWIFSLIKK--------------------CGLLHL-----QIFGDSL-- -----------GWIFLLIKK--------------------CGLLHF-----QIFGDSL-- -----------GWIFILIKK--------------------CGLLHL-----QIFGDSL-- -----------GWVFSLIKK--------------------CGLLHL-----QIFGDSL-- ------------------------------------------------------------ -----------RMVLVVVRS--------------------CGLLHL-----QIFSDAM-- -----------YWVLALIRK--------------------CGLLYL-----QIFSESI-- -----------AYVFQLIKK--------------------YSFVKL-----NLTGEAI-- -----------SWILLLIKS--------------------CGLLHL-----QISCDSL-- -----------TCVFQLIKN--------------------YSFVKL-----SLPGESI-- -----------AYVFQLIKK--------------------YSFVKL-----NLTGEVI-- -----------AMVFKVVRA--------------------YSFVRL-----SITGESV-- -----------IYVFQLIKN--------------------YSFVKL-----NLTGEII-- -----------AYVLQVIKS--------------------YSVVKL-----GLGPESL-- -----------SYVFQLIKS--------------------YSLVRF-----SLPGESV-- -----------ALVFQLVKS--------------------YSIVKL-----NLTGEAV-- -----------IWVFAMIKK--------------------CGLLHL-----QIFGETL-- -----------YLVYQLCLT--------------------CPF-GV-----VLKPQSA-- -----W----------------NLV-----KYYANRNPNSVRAL--------------LD -----W----------------DIT-----RSYVEGNATTVRSL--------------IE ------------------------------------------------------------ -----W----------------DLV-----KLFVEGNADSVRCL--------------ID -----W----------------NLI-----KVYVRRNPDSIRGL--------------ID -----W----------------NLI-----KIYVKRNPDSIRGL--------------ID -----W----------------DLI-----KIYVKLDPDSIRNL--------------ID -----W----------------NLV-----KIYVKRNPDSIRGL--------------ID ------------------------------------------------------------ -----W----------------NLV-----RVYVREYPDTVRSL--------------IE -----W----------------DLI-----KIYVHSNLETVRSL--------------ID -----W----------------NFT-----KIYAPKNISTVRGL--------------ID -----W----------------DFV-----KLYAKDNPETVRSL--------------ID -----W----------------NFI-----TIYVKDNSTIVRGL--------------VD -----W----------------NFT-----KIYAPKNISTVRGL--------------ID -----W----------------HFA-----SLYAPKNIHTVRGL--------------ID -----W----------------KFA-----RIYAEKNINIVRGL--------------ID -----W----------------HFV-----LVYVEKNTSLVRRL--------------ID -----W----------------HFV-----SIYVEHNATVVRGL--------------ID -----W----------------HFI-----CIYAAGNGTTVRSL--------------VD -----W----------------DMV-----TFYVEGNADTIRNL--------------ID -----W----------------RFV-----LRYYAKNSRPVLNL--------------LG GSLKPQ------------------------------------------------------ GSLRPT------------------------------------------------------ ------------------------------------------------------------ GSLKPK------------------------------------------------------ GSLKPR------------------------------------------------------ GSLKPL------------------------------------------------------ GTLKPQ------------------------------------------------------ GSLKPR------------------------------------------------------ ------------------------------------------------------------ GSLQPV------------------------------------------------------ GSLKPD------------------------------------------------------ GTFKSE------------------------------------------------------ GSLKPT------------------------------------------------------ GTYKSK------------------------------------------------------ GTFKSE------------------------------------------------------ GSFKSK------------------------------------------------------ GSFKSK------------------------------------------------------ GSFKSP------------------------------------------------------ GSFKSK------------------------------------------------------ GTFKSK------------------------------------------------------ GSLKPE------------------------------------------------------ GN--PD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------INTTRTQ-------LNWAKQIQTHLKM-------------- -------------------INTQKAQ-------LDRTYQIQQHIRY-------------- ------------------------------------------------------------ -------------------INTQKAQ-------INRIHQVQQQLKH-------------- -------------------INTQRVQ-------LDKSYQVQQHLKQ-------------- -------------------INTQRVQ-------LDKTYQVQQHLKQ-------------- -------------------INTQRVQ-------LDKTYQVQQHLRQ-------------- -------------------INTQRVQ-------LDKTYQVQQHLKQ-------------- ------------------------------------------------------------ -------------------INTQKAS-------LNRVYQVQQYVQQ-------------- -------------------INTNQAS-------LNRTYMVQAHIKQ-------------- -------------------FNDNKKSGN-----ISSISPVQKHLDL-------------- -------------------INAQKAQ-------INRVYQLHQHLKQ-------------- -------------------FNDNKKSGN-----ISCIGQVHKHFES-------------- -------------------FNDNKKSGN-----ISSISSVQKHLDS-------------- -------------------LNDNKKSGS-----ISSIPVLKKYLEQ-------------- -------------------FNDNKKSGN-----ISSISSVQKYLDT-------------- -------------------MNDNKKSGK-----ISSVPVLRKHLAE-------------- -------------------LNDNKKSGN-----ISSIGPLQRHLES-------------- -------------------LNDNKKSGN-----ISSIPSIHTHLQT-------------- -------------------INTQRAQ-------INRIHQVQQYIKQ-------------- -------------------LAEIAAMGL-----LEHARAFPQQYTQ-------------- -------------------LLETGKFD-RIDLKCFESL------------------LGE- -------------------LIEANKFS-RVDLKSLELL------------------LAA- ------------------------------------------------------------ -------------------LIESGKFT-RADLKAFQSL------------------VNK- -------------------LIESGKFK-RIDLRCVEDL------------------LSA- -------------------LIESGKFK-RLDLKCVEDL------------------LAA- -------------------LIESGKFK-RIDLRCVEDL------------------LAA- -------------------LIESGKFK-RIDLRCVEDL------------------LAA- ------------------------------------------------------------ -------------------RVEANRFT-RGDLKALEDL------------------LAA- -------------------LVETKKFS-RVDLKAFENL------------------LSGK -------------------IVTNGKFTKTEDLVILSML------------------LGQ- -------------------IVEGGKFT-RVDLKALESL------------------LST- -------------------LISNGKIQ-DQKLNTLSFL------------------LGQH -------------------LVTNGKFTKNEDLVILSML------------------LGQ- -------------------RILRGEFLEKEDLSTLSVL------------------LGQ- -------------------LIKNGNFT-HEDLTSLSLL------------------LGQ- -------------------QIGAGKFS-LHHLKYLAML------------------LGQQ -------------------LISNGKFT-DTDLNNLSLI------------------LGQH -------------------IITSGKFS-HHDLEALSHL------------------LGQS -------------------LVESGKFS-RIDMKAFECL------------------LSSN -------------------YYDSDGVS---NLVVLRSL------------------LDTG ---------------------------------------------GDHTKSNFNSSFLTT ---------------------------------------------DDKAKSSFTDNFVSA ------------------------------------------------------------ ---------------------------------------------KSLRPNKFADQFLTS ---------------------------------------------KSMQPNKFAENFFTA ---------------------------------------------KSIQPNKFAENFFTA ---------------------------------------------KSIEQNKFAENFFTA ---------------------------------------------KSMLPNKFADNFFTA ------------------------------------------------------------ ---------------------------------------------RSRAANTFVLSFVNV PVT------------------------------------------RKRQKESFAEQFFTT --NTTRTSTFSMG---------------------SNKSI---NK-KRNRSLPFAENFVNV ---------------------------------------------PGKYNRSFADQFLTV ASSATKLKTYTVTG----------------TSSNNSRNI---NK-KLTSSLAFAEAFVNA --NTTRTSTFSMG---------------------SNKSV---NK-KRNRSLPFAENFVNV --QITRSMTFTMGSQILVARHSTKNGINDNGSSNGSGGV--NNT-GNSSNLQFAGSFVTS --NTTKTSTFAMG---------------------SNRSI---NK-RSNRSSPFAENFVNT --TTGPVQKFSLSG----------------AK--TSKKIVSKDK-NKTAGVSFAETFVNE TSNVVSTTTFSLSG----------------GS--RTKNV---SK-KQSSSLQFAENFVNQ I-AASKAQVINITG----------------AGRGDHKKV----N-AKSNSTQFAEKFVTG ---------------------------------------------GKNRKTKFADEFMST ---------------------------------------------NKDKLEPLSQLFVGQ NW-VETLEQL-----WNKG----------------------------------------- KW-VDTLESM-----YGKE----------------------------------------- ------------------------------------------------------------ AW-IEMLESW-----WVKG----------------------------------------- NW-IEILEAL-----WAKG----------------------------------------- NW-IEILEPL-----WGKG----------------------------------------- NW-IEILEAL-----WAKG----------------------------------------- NW-IEILEAI-----WAKG----------------------------------------- ------------------------------------------------------------ QW-VNILEGM-----YQNE----------------------------------------- KW-LEQLEKW-----YNKG----------------------------------------- QW-IELLEKG-----YANG----------------------------------------- KW-VEILESW-----FMKD----------------------------------------- EW-IEMLERL-----YVNG----------------------------------------- PW-IELLEKG-----YANG----------------------------------------- DW-VEFLDGA-----YAEG----------------------------------------- TW-IENLEQS-----YVGG----------------------------------------- DW-IEALERL-----YAGG----------------------------------------- EW-VELLEKL-----YVNG----------------------------------------- AW-IELLESL-----YGGG----------------------------------------- TW-CESLESW-----WNKG----------------------------------------- KWLVNTLAAFPTETNYSQL----------------------------------------- -----------------QGRS-SEIVRQL--MLICLITSPDKVISKLLKDLEIS-----N -----------------PGSYLSDWGKKL--GILSFLSCSVTHLADLLKQMSIT-----N ------------------------------------------------------------ -----------------KGRY-NTIAKQL--LITTLLSVSTQTIANITRELGIS-----N -----------------QGRG-HKEAREL--IIISLFSVSADRLLKITKELGIS-----N -----------------QGRA-HKAAREL--IIISLFSVSAGHVLKITKELGIS-----N -----------------QGRA-HKDAREL--IIISLFSVSADHILGITKELGIS-----N -----------------QGRA-HKDAREL--IIISLFSVSADHILKITKELGIS-----N ------------------------------------------------------------ -----------------SNARLRTWARNL--GVLSYLSASETRLEELLRELDVV-----S -----------------SGNF-SEISQKL--GIISCLSVSVSKIASLFTDLGVN-----N -----------------KSVN-ADIIKDI--MIISIISLSAEKLATLTMNLGIT-----S -----------------AQPL-RDLTKNL--AILSYVTASENRVVELASELHVA-----N -----------------KSVH-AELIKEI--MIISLISLSTAKLAKLAMDLGVN-----N -----------------KSVN-AGIIKDI--MIVSIISLSTGKLATLTMNLGIT-----S -----------------KSVH-ANLIKSI--MVVSLISLSPAKLGKLLQNMGIN-----S -----------------KSVN-AETIKNV--MIISIISLSTAKLASLTMSLGIS-----S -----------------KSVH-AHIVKSA--MVISVLSLSPAKLAKVMSVLGIS-----S -----------------RSVH-ASVVKQV--MIVSLISLSTAKLLKVAMDLGVT-----G -----------------SSVH-ATTIEHV--MIISMVSLSPAKLAKLVTGMGIN-----S -----------------KGRS-SEVAQQL--AVVTLLTSSSTGISKVVRELGVS-----D -----------------TQKQ-KDLARAL--LYIVSTCLLSIPYISYFEKLMRS-----A I--ENLVMY----PLLGSI--ILNKSY--EKYN-------KSLKKDF------------- L--RTLSMY----PLLGSL--LIDARF--QEKL-------PHIKTKI------------- ------------------------------------------------------------ I--DTLSLY----PLLGCV--LLNDNL--SKRI-------PDLKSKL------------- F--ETLALY----PLLGTM--LINEGV--HKRL-------PDLKSKL------------- F--DTLALY----PLLGTM--LINERI--HKRL-------PELKSKL------------- F--ETLALY----PLLGTM--LINEGI--HKRL-------PDLKSKL------------- F--ETLALY----PLLGTM--LVNEGI--HEKL-------PDLKSKL------------- ------------------------------------------------------------ L--QTLAVF----PLLGSL--LISAAF--RERM-------PRLYIKV------------- L--ESLALY----PLLGSI--CINESF--KRRV-------PGLEKRL------------- I--AAFNVC----PLFSSI--IISEPY--KELI-------PNLEKKL------------- L--ESLQLY----PLFASL--LFNEQF--LIHF-------NGLKAKL------------- T--DSLVLY----PLFSTI--IISDAY--KELV-------PGLEERL------------- I--AAFNVC----PLFSSI--IISEPY--KELI-------PNLEEKL------------- W--ATLDVA----PLLGSL--LTSSAF--QELV-------PQIRETI------------- V--DTLKSC----PLFSSI--IISEPY--REMI-------PNLEERL------------- S--GTLAMS----PLLSAI--ILSEPY--KEMN-------PGLEERL------------- I--KTLKLY----PLFSTI--IISDAY--KHFV-------PNLEERL------------- P--EGLKMY----PLFSAI--LISDSL--SSLS-------PGIREKL------------- I--DTLSLY----PLLGSI--LMSEAY--QQKV-------PDIKSKI------------- LFLDLKKKY----HLAAVL--LCATNF--VDLIQVKFSKAAGFQGVI--SVLNIERDRLS --PFLNVNMSVPTSQYEDI-------------------------------EENYQIDQN- --PFLDIQEEPKAAPHLSG-------------------------------LLMPSVNVE- ------------------------------------------------------------ --GFLNLIPISTDASIETHMIDKVEPDGEGH-------------------FGDVTINEN- --LFLNLGGLSMDEGDHMSYPT----------------------------SSGTEVNEE- --LFLNLGSLSINDENNINYPV----------------------------STSTEVDEE- --LFLNLGALSMDDKDNMNYPT----------------------------SASTQIDEA- --LFLNLGASSMGDEDYMSYPT----------------------------SASTEVDEE- ------------------------------------------------------------ --PFLALVDYDGVEEESPP-------------------------------VDPVAADKA- --LFLNFVS-----------------------------------------GGEPSVNAD- --PFLRNIDIDDDNGYEDDD------------------------------LDGYEDNIE- --PFIRPVVHQDSDSGEL--------------------------------PVVDAVDAN- --TFLRNISFQDCSAI----------------------------------KEDVPIKEE- --PFLRNINIDEDGSYDDDD------------------------------LDGYEDNIE- --PFLQHDVTDLVDDHNNNSSSSNSNSNSNSNSNNNKNVDENNSYVKDYGKNEPKVKNE- --PFLRSLDEEEDDDEDYDD------------------------------DFGYEENIE- --PFLRSISI----------------------------------------KTAPSVNMK- --PFLRTIRFENDDHADDLSA-----------------------------VDLSSVNEE- --PFLANLKFSNKVSS----------------------------------PSSPAIKES- --YFLNVSTSNDSGMSTTN-------------------------------GAIDEVNEE- EKPQLRFPVTKTKNDYNDFSVVEDAVAS----------------------SSAAEPSDA- -----NIDSIKEIFPDLTDYQVELLLVK----FENNVETLTDALFED----PTIVESIPK -----QIDTIKELFPDLTSNQITKLLQR----YDNNTEVIINNLFEN----PSVISSLED ------------------------------------------------------------ -----DVTSLTELFPQFSRYQLTELLKR----YDSNVELITNTLFEN----PSVIDDIPK -----QLSALMELFPQFSKYQLSQTLLA----YDNNIELVTNKIFED----PTIIEAFSR -----QLSSLMELFPQFSKNQLLQALLA----YDNNIELVTNKIFED----STIIEAFAK -----HLSSLMELFPQFSKYQLSQALLA----YDNNIELVTNKIFED----PTIIQGFPK -----QLSSLMELFPQFSKYQLSQTLLA----YDNNIEIVTNKIFED----PTIIEAFPK ------------------------------------------------------------ -----ALATVHELFPQVTEYQVAQLLLT----HENNVELVINDLFED----PTLLDRIPA -----DIAAIGEVFPHLSKYQIEQLYKK----HDYNAEITTNALFED----PASADGIPR -----GISILVDLWPNMTERKAKIILKQ----HNGDVEHVTNLLLEN----PELIDKIEM -----SVQTILEVFPHLTISQVENRLKA----YDGNTERTIDSFFQA----NDQVDEVSL -----HIELLGDLIPQLTRGQAITILKE----NNDDVEQVTNILFEN----PDLISSIKE -----GISILVDLWPNMTERKAKIILKQ----HNGDVEHVTNLLLEN----PELIDKIEI -----DISVLMDLFPDLDARKARHFLKQ----YNNDSELVTDILLEN----PDLINQVTL -----AISLLVDLFPGMTEKKAKIVLKQ----NNGDVEHVTNMLLEN----PGLIDQIEE -----DVEFLVDMFPALTESKAKTVLLE----NDGNVEKVTNVLLEN----PSLVDSIAD -----NIFMLIDLFPELTQEKARLILHN----NDDNVERVTHMLLED----PSIIHSTNL -----DIDTLLDLFPQMTRGQAKTILFD----NDQNVERATNILLES----PDIISTIKE -----DVNMLAELFPIFTHYQLSELLVR----YDNNVELLTNILFEN----PSVADDIPK -----DAHTIMDMFPQFNLGQAKTLIQ-----HHVTTEGAMEYILSN----PDVMENPSS EKPKS-----------------------INTIKKP------------------------- GPL-------------------------QDDEIQN-----------TT--ENLMEEHKPK ------------------------------------------------------------ EPKTSHDANDNLGKQI------------LKSKPSP---------------VKSNIKNIEP EP--------------------------AEEEVEP-----------VS--DGDNASFTEE EP--------------------------EEAKTEA-----------VL--GELTLSD--- EP--------------------------KKKEMEQ-----------AL--DENNASSTDE EP--------------------------EEEEVEP-----------VS--GGNNTSFADE ------------------------------------------------------------ EEPTKPPLKVA-----------------NNRSKKK------------------------- EE--------------------------PTTAQSE----------------TKVQDDVKT ----------------------------------P-----------KK--TNNGTASTSN TERHDYP---------------------SNPKSRP---------------FKNQLQKVDK YEANNKPSNNKPRSKRTDFK--------QTESQDV-----------PI--AKRSVYDGDK ----------------------------------P-----------KR--ANNSTASNNI DKDETEEGEQEEEQEEENYGIENSIGTSEISAKQLESQIPRINTTKPV--AKRSVYDEDD QQ--------------------------KKKKKKP-----------VP--SNNN------ FE--------------------------ETQKKEI-----------TV--SQAELERGLA KKPNKPKKKPITKIN-------------LPKSKKP----------SVV--AKRSVYDDDE FQELNL----------------------VDETIQP------------------------- ----------------------------AATVVKP----------------KQEPQDKAK IPEWSS----------------------RATEGAP-----------AV--EISMDEYAPM ---------LSGPRYRRERRKSHEESEI-ISDRHVPDELRNKTLTRALELLYEKDEDE-- ENLLP----AITPKDKIEKKNML------FPTNDVPDAVRNKTLSRALSLLYDATEDE-- ------------------------------------------------------------ ELVLH----REMMKTKKQAIEQ-------ITKRHVPDEVRNKTLTRALKLLYENDEDE-- LSILD----RGDSSKNKELDKK-------IISEGVPDELRNKTLTRALKLLYEADEDE-- ---------RVPSSKNKNLDKR-------IISAGVPDELRNRTLTRALKLLYEADEDE-- LNILDR---IPSSKEKLDKK---------VISEGVPDELRNKTLTRALKLLYEADEDE-- LSLLN----RGPTSKNKNLDKK-------IISEGVPDEVRNKTLTRALKLLYEADEDE-- ------------------------------------------------------------ ---------ELRLRDRIVRKQL-------AYSSNVPDEVRNKTLTQALRLLYENDGDE-- TPKMP----FRSTDRITRKEEF-------ITSEHVPDELRNTTLTRALKL---------- NTKTF----TGSYKIFSGKKKGSLNNN--TKLNAPSADLKKKTLESALRLMYQSDEDE-- LTAAD----AD------------------SSTEHVPDEVRNKTLTRALALLYQADEDE-- FSNLD----FSEGSVIYGKKGQP------QNNEPTTETMKNKTLTAALRLMYESDEDE-- NTKTF----TGSYKIFSGKKKGNLSNN--VKLNAPSADLKKKTLESALRLMYQSDEDE-- ISQGN----FANTNVIFGKKKR-------EELTDADSDLKKKTLSRALRLIYEDDEDE-- ---------YNDPRVLQSKKNQK------FKLGQPSAELKKKTLSDALRVMYQSDEDE-- RFSLQ----ENETTEVLGKQSK-------EPEKASAEEMKKRTLSAALKLLYESDEDE-- ISRGD----FSKSSVIFGKKSS-------QAVGDLSEELKKKTLSAALRLMYESDEDE-- ---------VASSVARFTNSVKGDTLVKRKDPVVSTEELQKKTLSAAIRLMYESDEDE-- MEDVI----YPQVKKRNDK----------SFPKHVPDEVKNKTLTRALQLLYEDDEDE-- PVHAA----KSTPKYIFGKKEI-------STSLNPDEDAKSANLQHALRMIYESDEDE-- ------------HDDTYDESEVNHANLAEKISLEDEVDKTKST----------------- ------------RDDTYDDAEVKQASADRVSVDTSDTAKVSTI----------------- ------------------------------------------------------------ ------------RDDTYDEAEVKRSNTPIKIALGDDDGDSEQD----------------- ------------RDDTYDEADVNRSDPSKRIGLQEDEESYDTK-------------DDSN ------------RDDTYDEADVIRSGPSKRIDLQEDDERDGTG-------------DNTS ------------RDDTYDEADVSRTDLSKKIGFQDDENDEIDD----------------- ------------RDDTYDEADVSRSDPSKRIGLQDEEENDDAN-------------DDTK ------------------------------------------------------------ ------------RDDTYDEAETLHPTGERVQVEAAESPE--------------------- ------------------------------------------------------------ ------------PDDTYDDQEKTTGV---------------------------------- ------------KDDTYDEAEVQR-DATEELGVKEKSDHGEKL----------------- ------------PDDTYEEQEKTSGDAADEKNMTAKSKSNKNRLKIFDEEDGSGTDREAS ------------PDDTYDDQEKTAGV---------------------------------- ------------PDDTYDDQERTTGSTSESLQSQPNSKRVQPA------------EDGRN ------------PDDTYDDQEKTTGDDL-------------------------------- ------------RDDTYDDQEHTSGAAFYEYEKKPKNKDKARL---------AVFEDENE ------------PDDTYDDQEKTVGSALEDSSNKKKAGRGNLA----------------V ------------PDDTYDDQETTTTGFEKDVRQERDKGLETRQ----------------- ------------VDDTYEEAEVERSAVHGKVSIDDSNEKTESS----------------- ------------RDDTYEGM---------EGGTEEDSQANAKL----------------- ----NETNTNKIQSQFEANEKYLWE-LLKKDKE-IFSR--SRRGTKERKNI--KKETNWS ---------TPGTSKYDKIEGYLWE-LLKRDKN-LFSR--QQRGSKQRKEM--KKETNWS ------------------------------------------------------------ ------ASKEKNRNNYDAIEGYLWN-LLKEDKS-LFER--NKRGSKVRKDM--KAQINWS EVRQ--------DHNYHIVEAYLWN-LLKEDPK-LFER--SKRGTKVRKTM--KEMTSWS EVRQ--------VCKYDAIESYLWH-LLKEDPT-LFER--SKRGTKERKNM--KEQISWS -----DAKEKQQGDKYSAVESYLWN-LLKEDPT-LFER--SKRGTKVRKTI--KEKTSWS EVRQ--------GYNYNAIEAYLWN-LLKEDPT-LFER--SRRGTKVRKTM--KERTSWS ------------------------------------------------------------ ------------TSQYDRVEAHLWE-LLKKDKS-LFTR--EQRGSANRRDL--KQSTLWS ----------------------------------------FTKGTRTKETI--------- ------------------------------------------------------------ ---------------YEKIESQLWE-LLKLNKQ-LFDR--SSRNTKARKDL--KASTSWS KTPERSVSSSPMPASVDAIEKYLFS-IFKTKGADKFDK--KDRKSSDRQNI--KKSTNWS ------------------------------------------------------------ QTGN--------STVLDDRERFLFS-VYKRDGEDSFSK--AFRKSSQRQKL--KKETGWS ------------------------------------------------------------ PVPETQGSPAPAPPVVDKNELNLFG-YFKTEGEAAFDK--SSRKSKIRGEM--KNATKWT YEDGRESSPAPSNGAVDPKELHLFS-IFKTKGEEAFGK--AARKSSDRQSL--KKETSWS --------------AIDANSRYLFS-AFKLNNE-ALTR--SARKSAERQAM--RKATGMT --------------VHDKIEGYLWN-LLKEDPT-LFER--SKRKSKVRKDM--KGATSWS ----------------DKIQQYLFQ-LYSSNKQ-VFDK--LDRKSKARAEL--KKTTEWS DEQIEGWARMLERSPQRARILEEKY--MFRGN------VKRGKTSYVKNRDE-------- DEQIEGWSRMIEKSPKRAQLLEEKY--IFKGN------VRQGKKTFTKARED-------- ------------------------------------------------------------ DEQIEGWARMLERSPQRARILEEKF--MFRGN------KRSGKTSYVKNRDG-------- DEKIEGWCRMLERSPTRARLLEKKF--MFKGN------SKTGKTSYVHNRDS-------- DEQIEGWSRMLERSPKRAMLLEKKF--MFKGN------SRTGKTSYVHNRDS-------- DEKIEGWSRMLERSPTRARLLEKKF--MFKGN------NRTGKTSYVHNRDS-------- DEKIEGWSRMLERSPTRARLLEKKF--VFKGN------SKTGKTSYVHNRDS-------- ------------------------------------------------------------ DEQIEGWARMLERSPRRAQILEEKY--MFAGN------VRTGKKKFTQNSGD-------- -------LMMMLKSLSLQHLVAX------------------------------------- ------------------------------------------------------------ DEQIEGWARMLERSPRRAQLLEEKY--MFKGN------QRSGKRAFVQNKQT-------- DEQIEGWLRMLLKSPRRFKLLEEDY--LYGGN------PNRPIRRTNGGGQD-------- ------------------------------------------------------------ DEQVEGWLRMLLKSPRRFKIFEEDY--LYGGG------NPNRRSARNRNEERGSLGEKEK ------------------------------------------------------------ DEQIEGWFRMLHKSPKRFRLLEEQY--VFHFS------NKRR------------------ DEQIEGWLRMLMKSPRRFKILEESF--FFGGS------PNRPQKKIEEESRE-------- DEQIEGWFRLLLKSPRRFKILEEDY--FYGGN------PNRRNDKKDETNDT-------- DEQIEGWARMIEKSPKRAMILEEKF--MFRGN------KKSGKTSFVQNRDH-------- DEQIEGWARMLERNPRQFKMLESKQ--LEMGV------SKNDQPVAEEKKDK-------- ---------------------NSDNEAHTRPPKSNNNRDRKNPQSTKEDNQQTQQKSKKQ ----------------KEGFDHHVVDSTVNSPNTNSNNDSGREKTPTTKEPLTKEQQKRK ------------------------------------------------------------ -----------DSPVINDDRRRNQHQNPSRPKNKKNNTKKKGIDDAKKTNEATKSVAKGE -------------------QNDGNVVKEQAKQKKSENIKKHEPQSTEQ--------KKRQ -------------------EIDGSFDKEEAKRKASKEIKKDEPQSAEK--------KKRQ ------------------KNDEISTKEQTKHNALDNNNKKQEPQSAEK--------KKRQ -------------------KNDENVVKEEAKQNAPGNIKKHEPQSAEQ--------KKRQ ------------------------------------------------------------ -------------------QPAQSTEEPAASPRSDSNSAGRKQAPP----------SKKQ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SSSGQSKEEAKSNNGERNTPVTSKQPASSVG--KKRQ ----------------------------TGSSDLENNPNKPKSKDQ----------AKRS ------------------------------------------------------------ KEDLKSSDRNINTTPITTSTSNASNNASNNNSNNSNSNGKNKKNTNAPSTSSSKVESKRK ------------------------------------------------------------ ----------------------------TQRDAEVKETRKPSTPTPT---------DRRT -------------------------------STPVAESSRPESKTPQQ--------NKRS -----------------------------KKTKTTNETKDPKPQSKEQ--------IQRA ----------NREDSNEKGTTRNTSGTQKKKNKQQQQQQQQQQKPESSSKSNDSTGKKKK -------------------------EKGKGKGKEMEREMTPEQAAARQK-------QKQA FARNEKNKASRANHNRKAGNMKKQAKAGL------------------------------- NARNEKLKSSRANHNRKAGHDKKLAKSGVL------------------------------ ------------------------------------------------------------ PASTESTEPTETAKNKKPNEKKKASRSSHNRKSGFR------------------------ HAKNEKRKGARANHNRKKGHDKKLARAGNNAI---------------------------- RNRSEKNKGAKANHNRKKGHDKKLARA--------------------------------- HANNEKKKGVKANHNRKKGHDKKLARAGNNGT---------------------------- HAKNEKKKGAKANHNRKKGHDKKLARAGNNAV---------------------------- ------------------------------------------------------------ FAGNERNKRSRANHNRKAARGKKVSRGSEPQP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ NARKEKNKSVKGNHNRKSGHDKKMSRAAP------------------------------- FARNEKNKASKANHNRKSGHNKKTSRELAGMQ---------------------------- ------------------------------------------------------------ QARGEKNKALAANHSRKSQHDKKSKQALIGMQSSS------------------------- ------------------------------------------------------------ QARKEKNKAVVGNHNRKGRHNRKAQAELAGMQ---------------------------- QARNEKNKASRANHNRKSQQSKKARAELAGMQ---------------------------- QKRNEANKSSRANHSRKSRHDKKTQGALAGMQ---------------------------- YANNEKHKSSSANHNRKKGHDKKLSKVGI------------------------------- RDRRHKTQNKSSTHHRKSGHDRKMGKANFE------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MS-KIFIPTANCGKA------------ ---------------------------------MS-KLFIPTTNCGKA------------ ---------------------------------MS-KVFIATANAGKA------------ ---------------------------------MS-KVFISTTNCGKA------------ ---------------------------------MS-KVFIATANAGKA------------ ---------------------------------MS-KVFIATANAGKA------------ ---------------------------------MS-KVFIATANAGKA------------ ---------------------------------MS-KVFIATANAGKA------------ ------------------------------------------------------------ ---------------------------------MS-KLFIPTVNCGKA------------ ----------------------------MGPEDKR-KSFWCVKWYRSS------------ ---------------------------------MG-KQYISTVSASQA------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MS-KQYISTVSVSQA------------ ---------------------------------MG-KQYITTVNVSKA------------ ---------------------------------MG-KQYISTVSASQA------------ ---------------------------------MG-KQYISTVSAALA------------ ---------------------------------MP-KVYIASVNAPQA------------ ---------------------------------MG-KQYISTGTAAEA------------ ---------------------------------MS-KIFISTVNVGKA------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------HDADI-F--------------------------------------- --------------HETDI-Y--------------------------------------- --------------HEADI-F--------------------------------------- --------------HDADI-F--------------------------------------- --------------HDADI-F--------------------------------------- --------------HEADI-F--------------------------------------- --------------HEADI-F--------------------------------------- --------------HEADI-F--------------------------------------- ------------------------------------------------------------ --------------HNGDI-F--------------------------------------- ------------------------------------------------------------ --------------HKSDI-L--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------HKLDI-L--------------------------------------- --------------HKSDI-Y--------------------------------------- --------------HKSDI-L--------------------------------------- --------------HKSDI-S--------------------------------------- --------------HALDI-L--------------------------------------- --------------HSSDI-L--------------------------------------- --------------HDADI-F--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ --------------------GVAICN----T--FTVTC-SGDGYIKLWKNK--------- --------------------GLVITN----P--YTVSC-SGDGYLKLWNNK--------- --------------------SVTACN----S--FTISC-SGDGYLKLWDNK--------- --------------------KVAISI----P--FTITA-SGDGYIKLWKNK--------- --------------------SVSACN----S--FTVSC-SGDGYLKVWDNK--------- --------------------SVSACN----S--FTISC-SGDGYLKLWENK--------- --------------------SVSVCN----S--FTVSC-SGDGYLRLWDNK--------- --------------------SVSACN----S--FTVSC-SGDGYLKLWDNK--------- ----------------------MVCH-------RLAAT-DVKGNTLVWRFH--------- --------------------DVAVCN----A--FTVTC-SGDGHIKLWKNK--------- --------------------DHLLSH-------RLIAT-EVTGSTRVWKFH--------- --------------------GVAITN----K--FTVSV-SSDGYAKFWDNK--------- ---------------------------------------MERGGIE-------------- ------------------------------------------------------------ --------------------GVAITN----K--FTVSV-SSDGYAKFWDNK--------- --------------------GVEVTD----K--FTISV-SSDGYARFWDNK--------- --------------------GVAITN----K--FTVSI-SSDGYAKFWDNK--------- --------------------AVEITN----K--YTISV-SCDGDVAFWDNK--------- --------------------DVAITN----K--YTITV-SSDGCANYWDNY--------- --------------------DLVITT----R--YTLTV-SSDGYAAFWDNK--------- --------------------GVSVVN----P--FTVTC-SGDGSIKLWKNK--------- ------------------------------------------------------------ LLDNEQ-------PKD------------------------HVQKQFVHKSGVHHIDLI-D LTEDQL-------AKD------------------------HVIKEFVTPMGLHHVSAF-E LLDNEN-------PKE------------------------KSYAEFVHKTGLHHVDVL-Q LLENEQ-------PRD------------------------HYISQFINKTGVHHVDVF-H LLDNEN-------PKD------------------------KSYSHFVHKSGLHHVDVL-Q LLDNEN-------PKD------------------------KCYAQFVHKTGLHHVDVL-Q LLDNEN-------PKD------------------------KSYSHFVHKTGLHHVDVL-Q LLDNEN-------PKD------------------------KSYSHFVHKAGLHHVDVL-Q -------------PFA------------------------QEFDEELAKK---------E LLDGEV-------PKE------------------------HCVSHHVNKTGVHHVDVL-H -------------PFA------------------------QEIDE-------SRVDKR-E --QDEV-----HSPKE------------------------FVQSVFIDKSGIHAVAAYEN --------------------------------------------------VC-------- ------------------------------------------------------------ QDEVHL-------PKE------------------------FVQLVFIDKSGIHAVAVY-E --KDEV-----HDPRT------------------------SVQSLFIDKSGIHHVSVYEN --QDEV-----HQPKE------------------------FVQSVFIDKSGVHAIAVYEN --KDDV-----HTPSE------------------------HVVYKHIDKIGIHHVAVY-E QKENHN-------PFD------------------------FVLKKFVHKTGIHHVAVY-E --QEEN---HD--PHQ------------------------YVKRILINKMGLHHVSTY-E LLDDES-------AKD------------------------TVIEVFVHKTGVHHCETL-H ------------------------------------------------------------ T---VEKGGV--NVCIISCVTFSGEIVFFE-----LTQENQLK--PIKLLTEKELK---- S---VESNGE--TVIILSAISFDGKIYFYQ---IDLKE-GKLV-------KLSLLN---- T---IEKDAF--EICLVATTSFSGDLFFYR----ITRDNGSKK---VIFEKLDLLS---- S---MEAENL--ELLIITCVSFSGEISFWQ-----FDFNEKKL------NRIELFD---- A---IERDAF--ELCLVATTSFSGDLLFYR-----ITREDETK--KVIFEKLDLLD---- T---IEKDAF--DICLVATTSFSGDVFFYR-----ITREAETR--KVLFEKLDLLD---- T---IEKDAF--ELCLVATTSFSGDLFFYR-----ITREGETK--NVLFEKLDLLN---- T---IEKDAF--ELCLVATISFSGDLFFYR-----ITREDETK--KVIFEKLDLLD---- E-------EK-----RAKRLARGQSV-------------EDPS----------------- T---VERSGV--EICVIACVAFDGSLHFYS-----VNL-GEWT-----LTQMELLS---- D---------------------------YS-----IEE--------------EKLQ---- VLPSSTLKVT-----LLAFACFNGSIIFRY-----YIN-DDFS---TIESLTDDIK---- ---------------LVACTSFSGQLFLYS-----VDPKSEAL------EELDLLS---- ------------------------------------------------------------ NVL----PSSTLKVTLLAFACFNGSIVFKY-----YVN-DDFS---TIQSLTDDVK---- KLPSSTTKVT-----ICAFACFNGKIIFRY-----FLD-DNLE------TSLKELD---- TLP-----NSTLKVTLFSFACFNGSIVFKY-----YIN-DDFS----TLKDLTDVD---- T----VPAGSTTRVTVLAFACFDGAVRIFY-----YTN-DDLD-----TFTQLDLS---- N---VMPDST-IKLVVVAFVCFDGSIVFHY-----YTNDDAST--------LQVLE---- AVLPSSHVKV----LLVAFAAFDGSITLKL-----IVG-DDFE-------TLKEIP---- T---VEKGGN--EICLIACVSFSGEIFFYS---VDVKS-GKYE-------KLDLLN---- ------------------------------------------------------------ -----------------------------------------KSYWAVKWLQSSDLTVCHK -----------------------------ADD-------SKHSYWACQWYISTNPKNPHK -----------------------------TEM-------KKNSFWALKWCASNDRLLSHR -----------------------------SPE-WNK-----KSFWAIKWLKSDDQVLSHR -----------------------------SDM-KK------HSFWALKWGASNDRLLSHR -----------------------------SDM-------KKNSFWALKWCASNDRLLSHR -----------------------------TDM-------KKHSYWALKWCASNDRLLSHR -----------------------------ADM-------KKHSFWALKWGASNDRLLSHR -----------------------------TNS---------ENDEESKLQP--------- -----------------------------SEE--KQ-----RSYWSAKWHKSTYHSQAHK -----------------------------------------QQNEELEFQP--------- -----------------------------SFE---------SNCWTPGFYR-DPESKQDY -----------------------------KNE-------KLRSYWCIKFLKSDNLNVPHK ------------------------------------------------------------ -----------------------------SFR---------SNCWTPGFYR-DPESKKDY -----------------------------FVV---------EKAWVPGFYR-DPANKLDY ----------------------------ECSA---------GKSWNPGFYK-DPEAKQDY -----------------------------DFT---------SLCWCPAFYK-DPTSAQDF -----------------------------NHL-------FKKDYWAPAFYKDPVSKQDYF --------------------------VPVDLR---------KDCWGPCFYQ-DPESKQDY -----------------------------AAE-------KKRSYWAVKWFKSEDQVVCHR ------------------------------------------------------------ FAATDVKGSTYVWDLSVFQEGTADS----------------------------------- FIATTVQGTTKVWNFIIFQEPELDTETGEPLS---------------------------- LIATDVKGTTYIWKFYPFEDQT-------------------------------------- LAATDVKGTTYVWKFNPFPKDDGIENTDKTMTMSKLQLQ--------------------- LVATDVKGTTYIWKFHPFADES-------------------------------------- LIATDVKGTTYAWKFYPFADES-------------------------------------- LTATDVKGMTYIWKFHPFADES-------------------------------------- LIATDVKGTTYIWKFHPFADEA-------------------------------------- --QXKSHGEIP------------------------------------------------- FVATEVSGNTRVWRFHPFSKEVEELKIFEQDE---------------------------- --HLTLQGEIL------------------------------------------------- FITTKTNGTTEVHLLNIVDENE-------------------------------------- LVATDVKGSTFVWNLNVFKAASEDTEADSQP----------------------------- ------------------------------------------------------------ FITTKTNGTTEVYLLNIVDQD--------------------------------------- FLANKIDGLTEVYNLNVEQIGEDNVQIVFDKH---------------------------- FIVTRANGTTSVFLLNITDNEGVAEITFEKA----------------------------- FVVTKADGSVAVHPLNVQESDGAVTVEIRPLA---------------------------- VVQATGPTSVNFLNITIGKDNAVD------------------------------------ FVATKIGKGAIVYRLDITSPD--------------------------------------- FAATDVKGNTLVWRFHPFTEELDEEKAMKQKKTDEEKNAKRR------------------ ------------------------------------------------------------ ---------------DE---PQYNPHLKFQ-GEIPVK-----------------EPCV-A ---------------NS---LVYEPHFNFQ-GKINSQ-----------------TPRF-A -------GSSSPDWKPV---LELQGTIVSP-MT---------------------PNQF-A -------G-------EM-----PPPSA---------------------------EAVF-A -------NSLTLNWSPT---LELQGTV--E-SPMT-------------------PSQF-A -------GSSAPDWKPT---LQLQGII--E-SPMT-------------------PNQF-A -------DSSAPDWRPA---LELQGTV--E-APMT-------------------PKQF-A -------GSPAPNWSPK---LELQGTI--E-SPMT-------------------PSQF-A ---------------SV-------------------------------------EPVF-A -------GAEKSDTAVK---Q-QDDEL--E-LQPHFTLHGDLPAA---------SPKF-A ---------------SS-------------------------------------EPNF-A ---------------KAVITFEKFGQL--K-GN---------------------SSSF-P ---------------EKDLHLTLVGEI--PAS----------------------DPKF-A ------------------------------------------------------------ -------G-------KP---L-IT--F------EKYGQLKGN------------ASSF-P -------GLLGISSSPS---SSTTSSS----ASSTASNAT--------------GSSF-P -------G-------EL-----KP--N---------------------------SSTF-P -------G------------SLHASNT---------------------------ATSF-P ---------------IK---FEKAGEL--T-T----------------------HKSVFP -------GSNVEVSLDE---YGHLVGS---------------------------NGAF-P -------GESSGGEIEK---VPKQ-----E-DDEQLENLVLSPHLVLQGEIQPSNPIF-A ------------------------------------------------------------ TALDI--SSN------G-------------------------------------LIATGL TAVDV--SST-------------------------------------------QLIATGF TCVDI--SER------G-------------------------------------LIATGF TCVDM--SHN------G-------------------------------------LIATGF TSVDI--SER------G-------------------------------------LIATGF TCVDI--SER------G-------------------------------------LIATGF TSVDI--SER------G-------------------------------------LIATGF TSVDI--SER------G-------------------------------------LIATGF TCVGI--SHN------G-------------------------------------LVATGF TCVDV--SVK-------------------------------------------NLVATGF TSVDV--SSN------G-------------------------------------LIATGF NSLAICPTEN-------------------------------------------KKCAVGY TCVDI--SAK------G-------------------------------------VIATGF ------------------------------------------------------------ NSLAI--CPT-----------------------------------------ENKKCAVGY NSLAVNQTEN-------------------------------------------KKCAIGY NSLAI--CPT-----------------------------------------ENKKCAVGY NTLAV--SSC------------------------------------------DSLCAVGY NSLAVTRSDD-------------------------------------------LLAAVGY NSIDISNSTE-------------------------------------------AKVAIGH TCVDF--SGK------G-------------------------------------LIATGF ------------------------------------------------------------ ENGTVFVSQLTS-LKPLY-QFEGYGLHGIDQ------N---------------------- SDGSVVVSQLST-LRPVY-NFEGFGLKGVEE------S---------------------- NNGTVQISELFT-LRPLY-NFESQHSMIN--------N---------------------- ANGTIVVSQLST-LRPLY-NFEGFGIQGIEQ------N---------------------- NNGTVQISELST-LRPLY-NFES--------QHSMINN---------------------- NNGTVQISELST-LRPLY-NFESQHSMIN--------N---------------------- NNGTVQISELST-LRPLY-NFESQYSMIN--------N---------------------- NNGTVQISELST-LRPLY-NFESQHSMIN--------N---------------------- ANGSVVVSESST-LRRIH-NFEGFGIQGIEQ------N---------------------- SDGSVVIAQLST-LRPIY-NFEGFGLQGTQD------N---------------------- SDGSVVVAQLRT-LRPIY-NFEGFGIQGIEE------N---------------------- INGDVLLYDFVS-LKLIY-TFRSSDLVTSRNS-----Q---------------------- QDGSVVVSQLET-LRPIY-NFEGFGIKGTEE------S---------------------- ------------------------------------------------------------ INGDVLLYDFVS-LKLIY-TFRSGDLVTSRNSQ----S---------------------- MNGSVLLFDFET-LKLTY-TFKSTDLVISKNPKLNSSS---------------------- INGDVLLYDFAS-LKLVY-TFHSSDLVTSRNSQ----T---------------------- ISGDVVVYNLTS-QKALF-TFHSTDLQ----------HKGKG------------------ ANGDVYVYDLKL-MRTLY-TFRSTDLVVETKGG----N---------------------- SNGDVLLYDLET-LKPYY-TFRSTDLQQSTTGA----H----G----------------- SNGSVQVAQLST-LRPIY-NFEGFGIQGTDQ------N---------------------- ------------------------------------------------------------ -----------------SNT-VRNVKFSPTGRLLAVANDSGSYGNITLYETEFGERI-GN -----------------SST-IRDIKFSPAGSLLAVAHDSGSYGCVSLYETEFGERI-GN -----------------SNS-IRSVQFSPQGSLLAIAHDSNSFGCITLYETEFGERI-GS -----------------SNT-VRAVKFSPAGSLLAVANDSGSFGCVALYETQFGERI-GN -----------------SNS-IRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERI-GS -----------------SNS-IRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERI-GS -----------------SNS-IRSVRFSPQGSLLAVAHDSNSFGCITLYETEFGERI-GA -----------------SNS-IRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERI-GS -----------------SNT-VRAVEFSPLGTLLAVASDSGSYGCVSLYETEYGERV-GS -----------------SNT-VRALKFSPLGGLLAVANDSGSFGCVTLYETEYGEPV-GS -----------------SST-VRDVKFSPLGGLLAVANDSGSYGCVTLYETEYGERV-GN -----------------STSIPRVLAFSPGGTLLAVARDNQAAGSITLYDVEHGENV-GS -----------------SGT-VRDVKFSPMGELLAVANDSGPYGCVTLYETEYGERI-GN ------------------------------------------------------------ -----------------TSI-PRVLAFSPGGTLLAVARDNQAAGSITLYDVDHGENV-GS -----------------SVP--RVLAFSPGGTLLAVGRDNQAAGSITLYDVEYGENV-GS -----------------TSI-PRVLAFSPDGTLLAVARDNQAAGSITLYDVQHGENV-GF -----------------STAIPRALAFSPGGTLLAVSRDNQSAGSITLYDVKYGENV-GS -----------------SVAMPRVLKFSNDSKFLAVARDNQASGSITLYDVKFGEYI-GN -----------------SSSIARVVKFSPGGSMLAVARDNQSSGSITLYDVKYGEDV-GS -----------------SNT-VRALKFSPMGSLLAVANDSGSYGCVTLYETDYGERI-GG ------------------------------------------------------------ FTMATHST----QTSIGSFAHD---G----WVFGLAF-NE-------------------- FTVPTHGN----QTTIASYAHN---G----WVFSVSF-NS-------------------- LSVPTHCS----QTSLGEFAHS---S----WVTSLSF-ND-------------------- LTVPTHSG----QSSVESFAHS---G----WVFALSF-NS-------------------- LSVPTHSS----QASLGEFAHS---S----WVMSLSF-ND-------------------- LSVPTHSS----QASLGEFAHS---S----WVTSLSF-ND-------------------- LSVPTHSS----QASLGEYAHS---S----WVTSLSF-ND-------------------- LSVPTHSS----QASLGEFAHS---S----WVTSLSF-ND-------------------- LTVPTHSA----QTSIGTFAHD---G----WVFGLSF-NP-------------------- LTVPMHSN----QQSIVSVAHS---G----WVFGLSF-NS-------------------- LTVPTHSA----QTSVGSFAHD---G----WVFSLSF-NS-------------------- LATPSHSAKSVV----GGFAHQ---G----WILGLSF-DE-------------------- LTVPTHSTQTSI----ANFTHD---G----WVFNVSF-NS-------------------- ------------------------------------------------------------ LATPSHSAKSVV----GGFAHQ---G----WILGLSF-DE-------------------- LVAPSHSAKTVV----GGFAHQ---G----WIMGLDF-DE-------------------- LAAPSHSSKSVV----GGFAHQ---G----WILGLSF-DE-------------------- LTGPSHSSKATV----GGFAHG---G----WVTGLSF-NG-------------------- LTSQNITINNVI----GGFAHS---G----WIMGLSF-DE-------------------- LTTPSHSS--------GGFAHD---G----WVMGLCF-DE-------------------- LTVPTHST----QTSIGSYAHN---G----WVFDLSF-NS-------------------- ------------------------------------------------------------ --TGEFLASCGYDSKVRVWDVKLR-ERVSTLH---------------------------- --TGEYLASAGYDGKIRIWDTKSR-ERVSTLN---------------------------- --SGDTLCSAGWDGKLRVWDIKTK-ERITTLN---------------------------- --TGEFLATSGYDSKVRVWDVKSK-ERVTTLN---------------------------- --SGETLCSAGWDGKLRFWDVKTK-ERITTLN---------------------------- --SGETLCSAGWDGKLRFWDIKTK-ERITTLN---------------------------- --SGETLCSAGWDGKLRFWDVKTK-ERITTLN---------------------------- --SGETLCSAGWDGKLRFWDIKTK-ERITTLN---------------------------- --TGEFLATCGYDSKVRIWDVKLR-ERVSTLN---------------------------- --SGEYLASCGYDAKVRVWDVKLR-EHVSTLH---------------------------- --TGEFLASCGYDSKVRVWDVKLK-ERVSTLN---------------------------- --EGKHLASCGFDKCIRVWNLETS-EREATIS---------------------------- --TGEYLATCGYDGKIRVWDVKQK-ERVSTLN---------------------------- ------------------------------------------------------------ --EGKHLASCGFDKCIRVWNLETS-EREATIN---------------------------- --SGKFLVSCGFDKSVRVWDLDTR-EREATIN---------------------------- --EGKHLASCGFDKCLRVWNLETS-EREATIN---------------------------- --DGSLLASCGFDRCVRVWNIESR-EREATVQ---------------------------- --HSTLLASCGFDKCVRIWNLESR-EREATIN---------------------------- --TGDLLASSGFDKCVRIWNLDTR-EREATIS---------------------------- --TGEYLATCGYDSKVRVWDVKSK-ERVSTIN---------------------------- ------------------------------------------------------------ --ITAGDIEVEEDILQEDEEGNSLKHPPIF-DVK--F-IKKG------------------ --VNTTDIEIEEDIVLEDEHGDSLEVPPVL-AVS--F-FDKC------------------ --MHCDDIEIEEDILAVDEHGDSLAEPGVF-DVK--F-MKKG------------------ --ITAGDIENEDDILLEDENGDSLKYPPVL-DVS--F-INKG------------------ --MHCDDIEIEEDILAVDEHGDSLAEPGVF-DVK--F-LKKG------------------ --MHCDDIEIEEDILAVDEHGDSLAEPGVF-DVK--F-LKKG------------------ --MHCDDIEIEEDILSVDENGDSLADPGVF-DVK--F-LKKG------------------ --MHCDDIEIEEDILTVDEHGDSLAEPGVF-DVK--F-LKKG------------------ --ISAGDIEVEEDIMLQDENGESVKNPPVM-DVK--F-INKG------------------ --MSSDDIEDERDMMTVDEHGTSLKAPPVL-GVC--F-VDKG------------------ --ISAGDIEIEEDILLRDEQGNSLKNPPVM-AVT--F-INKG------------------ ----ISISDLDDTTHNDQDE-------SVASGVA--F-IKKG------------------ --ISAGDIEIEDDIVAQDENGDSLKTPPVM-GVT--F-INKG------------------ ------------------------------------------------------------ ISVS--DL--------DDTTHDEQDESVAS-GVA--F-IKKG------------------ ----LSVSDFDDTEADEQDQ-------SIASGVK--F-IKKG------------------ ISIS--DL--------DDTAHDEQDQSVAS-GVT--F-IKKG------------------ -----LSVSDLDFEPEDSDD-------SVCSGVA--F-IKKG------------------ ---LTLSDLVDTPFDEQFDK-------CVASGVA--F-IKSG------------------ ---------ISISDLESTDGNEELDTSVAS-GVK--F-IKKG------------------ --LSAGDIEIEEDILMVDENGDSLKNPPVM-GVR--Y-INKA------------------ ------------------------------------------------------------ --VRAGMGSDVNEGL--------------------------------C----C------V --VRSGMGGSTNEGI--------------------------------C----C------V --WRSGMGADLNESL--------------------------------C----C------V --IRSGMNSDVNEGL--------------------------------C----C------V --WRSGMGADLNESL--------------------------------C----C------V --WRSGMGADLNESL--------------------------------C----C------V --WRSGMGADLNESL--------------------------------C----C------T --WRSGMGADLNESL--------------------------------C----C------V --VRGGMGSETNEGL--------------------------------C----C------V --VRGGMSADINEGL--------------------------------C----C------V --VRGGMGSDTNEGL--------------------------------C----C------V --VRGGSGGDSNEGL--------------------------------C----V------V --VRSGVGSDTNEGL--------------------------------A----C------V ------------------------------------------------------------ --VRGGSGGDSNEGL--------------------------------C----V------V --VRGGAGGDSNDGI--------------------------------C----V------V --IRGGAGGDSNEGL--------------------------------C----V------V --VRGGAGGDANEGL--------------------------------C----V------V --IRGGPGKDNNESL--------------------------------C----V------I --IRSGSGGDTNEGL--------------------------------C----V------V --VRGGMGSETNEGL--------------------------------C----C------V ------------------------------------------------------------ CLDRSVR----WY---------------REAGGS-------------------------- CSDRSIR----WY---------------REAGGI-------------------------- CLDRSIR----WF---------------REAGGK-------------------------- CLDRSIR----WY---------------REAGGN-------------------------- CLDRSIR----WF---------------REAGGK-------------------------- CLDRSIR----WF---------------REAGGK-------------------------- CLDRSIR----WF---------------REAGGK-------------------------- CLDRSIR----WF---------------REAGGK-------------------------- CLDRSVR----WF---------------RAAGGS-------------------------- CLDRSIR----WY---------------REAGGI-------------------------- CLDRSVR----WF---------------REAGGV-------------------------- SFDRGIR----WY---------------REAGGI-------------------------- CLDRSVR----WF---------------REAGGV-------------------------- ------------------------------------------------------------ SFDRGIR----WY---------------REAGGI-------------------------- SFDRGIR----WY---------------REAGGI-------------------------- SFDRGIR----WY---------------REAGGI-------------------------- SFDRGIR----WY---------------REAGGI-------------------------- SFDRGVR----WY---------------REAGGV-------------------------- SFDRGIR----WY---------------REAGGI-------------------------- CLDRSVR----WY---------------REAGGS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LISLGHFCDIHGPTII --------------------------------------------FLSLTHFCDKHGPKVL --------------------------------------------VISLAHFCDKHGPRII --------------------------------------------LISLAHFCDKHGPQVI --------------------------------------------VISLAHFCDKHGPRII --------------------------------------------VISLAHFCDKHGPRII ------------------------------------------------------------ --------------------------------------------VISLAHFCDKHGPRII ------------------------------------------------------------ --------------------------------------------LVSLTHFCDKHGPKLL --------------------------------------------LICLAHFCDKHGPRVL --------------------------------------------MVCLAHFCELHGPSVI --------------------------------------------LITLAHFCDKHGPRIL --------------------------------------------IACLAHFCELHGPSTI --------------------------------------------MVCLAHFCELHGPSVI --------------------------------------------IVSLSHFCELHGPSVI --------------------------------------------IVCLAHFCELHGPTVI --------------------------------------------LFCVAHFCELHGPSTL --------------------------------------------IVCLAHFCELHGPSTI --------------------------------------------IVALAHFCELHGPVSI ------------------------------------------------------------ --------------------------------------------LLCFAHFCDLHGPTSI IVTQEGPTESYCESCMVKIPDCDSIRSKLGEKSFVSSQYSAIRYQLLTSMIRKAFSEETM MVTQIAPKDSYCDSCLLRLPEPKSIRSSIDDFYSVSTQYSSIRYQLLSMIIKKTFSEETM SVTQSAPTDSYCESCLLQFPEESSMRCFIEDVPFITTQYSSIRYQLLNSIIKRAFSEETM LVTQTSPIDSYCESCLLHFPDNESMRSILHERPYITTQYSAVRYQLLNAIIRRSFSEETM SVTQSAPTESYCESCLLQFPEESSMRCFIEDVPFITTQYSSIRYQLLNSIIKRAFSEETM SVTQSAPTDSYCESCLLQFPEESSMRCFIEDVPFITTQYSSIRYQLLNSLIKRAFSEETM ------------------------------------------------------------ SVTQSAPTESYCESCLLQFPEESSMRCFIEDVPFITTQYSSIRYQLLNSIIKRAFSEETM ------------------------------------------------------------ VVTQCAPSDSYCDSCHISFPQESSIRSTIGERYYVSTHYSAVRYQYLTALVKKIFSEETV MVTQCAPTDSYCESCLIHFPESSSMRSTIGSTYYVSTQYSSIRYQLLTSITKRTFSEETM ACTQIISRSASCLSCQFILPDSTTPTDSILEKVSISTHYPSSRYSALTKLVMKSLSVETM LGTQFAPTDTYCDSCSIHFPDKSSMRSTLHSVEFVSTNYPSLKYQLIYSVIRHMFSEETM ICTQMTSKLHSCASCKLILPDDANKNESNTPAVYISTHYPSSRYAALTKLIMKSLSVETT ACTQIISRLTSCLSCQFILPDSTTSTDAIIGKVSISTHYPSSRYSALTKLVMKSLSVETM ACTQTISRSASCASCQLILPDAGLSSKSKGTHSFVTTHYPSSRYSALTKLVMKSLSVETN ICTQITSRLANCLSCQLILPNSSGKKEEEEPKVSVSTHYPASRYSALTKLVMKSLSVETT LCTQKQSSSASCAACALSLPNGASVVSETRDCSWVSTKYPTSIYTSLMKLVMKCLSVESA VCTQVTAKFQTCASCNLILPDGSRTNGPGKNSVYVSTHYPTSRFASLTKLVMKSLSVETN ICTQQTSKVQTCASCKLVLPQDATNDANGAHTVCISSKYPSSRYTALTKVVMKALTVETS ------------------------MRSNIGETSYVSTQYSSIRYQLLTLIIRKVFSEETM LCCQKTNECSTCANCQLILPNDATLRSNIGEHTYVSSQCAVGDYSKVRKACLKLLSSET- IYDGSPSVFYDESKGLNLVMGFKLHDPNARGNERRYCLILTIESVDEIAAHWHFIVGGFS SYDGSPFMFCDEHRGLNLAVGFKLEDVHARGNERRYCLILSLEKRDGLSDNWQFIIESLS IYDNMPFIYFDDLRGLNLVIGFKLYDENARGNERRYCFILTVDSRNHLSENWNFIIGGFD VYDSLPNVFHDNVSGVNLVMGFKLYDENARGNERRYCLILTIDDKDELSNNWNFITGGFL IYDNMPFIFFDDLRGLNLVIGFKLYDENARGNERRYCFILTVDSRSHLSEHWNFIIGGFD IYDNMPFIFFDDLRGLNLVIGFKLYDENARGNERRYCFILTVDSRSHLSEHWNFIIGGFD ------------------------------------------------------------ IYDNMPFIFFDDLRGLNLVIGFKLYDENARGNERRYCFILTVDSRSHLSEHWNFIIGGFD ------------------------------------------------------------ SYDGSPLLFYDHARGLNLAMGFKLEDPHARGNERRYCLVLTVDLRERVSQHWKFISGAFE TYDGAPLVFYDDMRGCNFVIGFKLQDVNARGSERRYCLILTIDSRDNLSQNWEFIVSGFA SDLSKPMFYGDAINGYCINQIFKVEDLNARGGERKYSLMVISDNESELLMRWEIVSIYFN TYDGTPLTFYDQGKGLNVAVGFKLQDSDARGDERRYGLLLTIDSPDHLSRHWDFVNYSFS TDLSKPIFYGDVVNGYCISKIFKIKDLSSRGSERKYSLMVIADFETKLLQNWDIIATYLN SDLSKPMFYGDAINGYCINQIFKVEDLNARGGERKYSLMVISDNESELLMHWEIIGIYFN LDLSKPMFFGDAINGFCMNKIFKLYDINARGQERKYSIMVVSDSESDLLERWDIVSIYFS SELSKPMFYGDAINGYCINQIFKIEDINARGGERKYSLMIVSDDEFELLNNWDILQMYLN ADPSKPVFFGDTASGFCLAKVFSLRDVHARGGERKYALMLVSDSESAVVHGWGVAAQYFA SDVQKPMFYGDVINGYCINKVFKIKDINARGSERKYSLMVVSDSESDLLLNWDIVSVYFN ADPKRPILYGDSVDGYCMSRVFKVRDPSARGGERKYSFIVLCDSESHLSSNWEIIAMYIG VYDGSPLVFYDDIRGLNLVMGFKLYDEHARGNERRYCLTFTIDSDDHLANNWNFIKCGFE TFSDTPLMFGDSS-GATIGYVFKVNDNESRGGIRKYGFLCLGEEKR-LMDNWIPITERFE MMINAIKEKHAQNNDGLESNTQDGNYLRANKGKARNLSELTNDKFTFLRIHKWNTYMIDT KLIDHIKIQAREQLNRRQTDQIMGTYLRENKQKPVSLADIVNDQLIFLRIHKWNTFILTR KMITYIKNIHKSEFMGKNQRAFIGSYLRANKSKGRNLVSLTDDKFLFVRIHKWNSFLLHT KMINYIKDSHAKELERKTTSPFMGNYLRGNKSKARNLIELTNDKNIFIKIHKWNTYLLDA KMIAYIKNIHKSEFLGKNKTAFIGSYLRANKSKGRNLVSLTDDKFLFVRIHKWNSFLLHT KMITYIKNIHKTEFMGKNQTAFIGSYLRANKSKGRNLVSLTDDKFLFVRIHKWNSFLLHT ------------------------------------------------------------ KIIAYIKNIHKSEFLGKNQTAFIGSYLRANKSKGRNLVSLTEDKFLFVRIHKWNSFLLHT ------------------------------------------------------------ NMIEYIKQQRRAELLRVMQQSMVGTYLRGNNLKPKNITELTNDRLLFVRIHKWNAFILDR KIIEYTRQKRAEEISRRQRQPMVGNYLRGSNLKPKNLTELTSDSRFFLRLHKWNAFMLDR VVIELIQKKVAKANQVKQSEMFDERYLRRSLIKPKSLTELTNDNEIFVRIHLCVTEMLKD KIIQYTKQRRDDEVRRKASNTPMGSYLRGNKLKPRNLAYLTNDDLLFVRLHKWNTFMLDV EIISLIQAQVDIVINNAIMKMFDERYLRRSLIRPKSLVELTDDDQIFVKFHLWAIELLKD VVIELIQKKVDKANQVKQSEMFDERYLRRSLIKPKSLTELTNDNEIFVRIHLCVTEMLKD ELISLIQHKVSETNKRIHEHVLDEKYLRRSITRPKSLVELTGDDQIFLKLHLWAIELLKD EIIELIQKKVIDWNQRNEVSVLDERFLRRSLNKPRSLTELTNDDEIFVKLHLLATELLKD EIITLVQRQVEKRRESSLSGGVDERYLRRSKNVPKSLVELTGDSQIFVKLHRVAAELLAD EIIALIQEGVERTYEESLIRMLDERYLRRSMIKPKSLVELTNDDQIFIKFHLWAMELLKD EMISHIQEKVEARRSSGATEEIDEKYLRRSMARPKSLVELTGDDQIFVRLHMWAREVLRD KFIAYIRQTYESENEKREISPLVGTYLRANKVKSRNLVELIKDDMLFLRLHRWNAYLLNG SMGGWIKTQVTKHQEMKDKSDWADSFRREAFTKPKNLVSMTKDDEFYVKVHAGLSDLLNK LCDESYNSGSNIMINKKSLLYVQDSTSLVFGLAAGILQLESWDGFLAFLGCYTTVCLIFI LKSYRFKSSKSGSFNNNKLLRIQDSTMLTAGLSAGILQLQSFAGFGMFFAVYILVNLIFI VMEEVFNATVNVVDNKKRLLFVQDSCALVLGLVAGFLQIESVRGFLWFLALYNLINMVYI LLEDQFRSTVNVGSNKKSLLFVQDSTMLIIGLGAGILQLESLNGFLMFAICYILVSIVFV VMEEVFNATANVVDNKKRLLFVQDSSALVLGLVAGFLQIESVHGFIWFLILYNLINVIYI VMEEVFNATANVIDNKKRLLFVQDSCALVLGLVAGFLQIESVSGFLWFLVLYNVINVIYI --EEAFNATPNVVDNKKRLLFVQDSSALVLGLVAGFLQIESIHGFTWFLVLYNLINVIYI VMEEVFNATANVVDNKKRLLFVQDSSALVLGLVAGFLQIESVNGFIWFLVLYNLINVIYI ------------------------------------------------------------ LGNPVSLSSRSVSFNKKRLLYVHDITSLVFGCGAGILQLESLQGFIMFAVSYLSISAIFA LNQETFKSSRSIEFNKKSLLYIQDVTSLVFGCGAGILQLESSKGFILFFLSYIAIALSYI ILTQKFYYQPSIEANKQKLQHVHDVASLALGVGSGILTLESMNGFIFYLIGITVTNLLFY LRQDAYKSQESISFNKKVLLYIQDGTSLGLGCGAGILQLEGLRGFGLFVAGYTLVSMIFT ITMSETYYISSIEANKKKLQHVHDIMALALGVGAGVLTLESVYGFLFYIIGFTITNLAFY ILMEKFYYQPSIEANKQKLQHVHDVASLALGVGSGILTLESMNGFIFYFIGITVANLLFY VAMSSVYSQANIDTNVQKLQHVHDVTSLVLGVVAGIMTLESLYGFAVYIIGILITNLAFY INPEKFYYQPSIEANKQKLQHIHDVASLALGVGSGILTLESLNGFIFYLVGITATNLLFY LRPESGYFEPNIAVNKQKLQRVQDVMSLALGVSAGILNLESVYGFLFFLVAFSLSNLAFY IL--MSYYTPSIESNKQKLQHVHDIASLVLGVGSGVLTLESAYGFIFYVVGITLTNLLFY VQ---------------------------------------------------------- ILHEDMHSFENVSSNKKTLLYLLDSTSLVFGIGAGILQLESIYGFLMFFCCYFVVSTIFI VADDWALAGQSIAENTKSIQYVRSVSSLAIGVGAGILHLESYYGFLFYAIASTIVSILLY LWTCQLKPQKFFQSPIQDIFIESLFRELTGFVMAWTFSYALVGEEVTFAELKELAGSIKE AWFCKFKPSLYFTNPVHKIWVKNLFRELAGFVMTWTLAFTLVR---MSSTLSDDIKRLKT VWICQLQPGKFYQSPLQDIFFESFFRELTGFVMAWTFGYALIGDITDDIRLLELLDSIED LWLCEGKPGRFFENPIQDILMDSFFRELMGFIMAWTFSYALVGETITKEQIGELLESIKS VWICQLQPGKFYQSPLHDIFFESFFREITGFVMAWTFGYALIGDRKDDVKLLELLNSIDE VWICQLQPGKFYQSPLQDIFFESFFREITGFVMAWTFGYALIGHIADNERLLELLDSIEK VWICQLQPGKFYRSPLQDIFFESFFREITGFVMAWTFGYALIGSIKDNEKLLELLDSIEE VWICQLQPGKFYQSPIQDIFFESFFREITGFVMAWTFGYALIGDVKDDVKLLQLLNSIEE ------------------------------------------------------------ MRLCKFEPSKYFQNPVQDIILTSLFRELAGFVMAWTFTYALLSRQDMAEELGQLLASFRE GLFCQFKPGKYYQSPIQEIFVDSLFRELAGYVMTWTFVYALVGETFDESHILQLVSNIRT IICGEGRPSKYFKNPLQEVFISGVFSNIPGFIMMWCLVYALVKELKTQNDLKNLLQSFKQ GWFCGFNPGKYYQSPVQEIYVDSFFRELTGFVMAWTFVYALVGEPFTASDVASLVRTLRT RICCEGKAFEFFRKPLHEIFVDGIASNVAGFLMMWCLVFALVKMAKDRLDLKNLIQSFKE IICGEGRPSKYYKNPLQEIFVSGIFDNIPGFIMMWCLVYALVKEPKTQDDLKKLLQSFKQ IICGEKQANKFFKKPIQEIFVNGLLNNTPGFIMLWCLVYALVKLSMTTKDIEALIVSFRD IICGESKPSKYFKSPIQEVFLNGIFSNLSGFIMMWCLVYALVKTTKTRDDLKNLLDSFNE LECCKGEADKYFESPSRQIFLDGLFPALSGYVMSWCLTYALVNDLYSMANLNDIIKAFEE LICCEGQPHKFFKKPVQEVFLDGVLTNVAGYIMMWCLVYALVKMSKTKADLKDLLASYKE -------------------------------------------MVPTSNDLLKLLKSFSE AYICKFKPSKYYVNPIQEIYFDSLFRELAGFVMAWTFSYAFVGKSITRENIRELVDNIDS TVSSTGNPGRYFVYPVKQLFVDDIFAGLSSFLLMWTLFYELVD----------------- QFVDPYNDIGALKKISETKLQGPLTELEKLAKILKAYSTKLGIICEPSKLHGNYHAAYTE EF--PYTSVESLHGIKKTKLPALLEELGKLSKLIKSNATKLGIISTPDKISNNEDAFKTQ QFLTTYKNSEDLHKISTTKLQDPINELGKLSSVLKAHCTKFGIVCKPGTFDNNHKVVFTE QFIEPYNKIDAIHNITSTKLKDALLELSKLSQLIKSQSTKLGIVTQPENFNKNYRAIYTE QFLVPYKKPEDLRKISTTKLQGPTKELDKLASVLKAHCTKIGIVCKPGTFDNNHKVVITE QFLVPYEKPADLRKISTTKLQDPIKELEKLASVLKAHCTKIGIVCKPGTFDRNHKVVFTE QFLVPYKKPEDFRKISTTKLQDPIKELGKLASVLKAHCTKIGIVCKPGTFDSNHKVVFTE QFLTPYKKPEDLRNISTTKLKDPIKELDKLASVLKAHCTKIGIVCKPGTFDSNHKVVFTE ------------------------------------------------------------ RF--AYGTRDELAAISSTQLQDPLLELAKLAKLIRAQTTKVGILSQPARREGNESTCGKE QFLEAYPSADSLHKISSTKLEGPLVELGKLASIIKAHSTKVGIIYNPDTLFKNISTAFKE EFWIQSININKFDEITTTTIDNPQQELIKLIKLIKAHTTKVGIIFKPTNLFKDPNVAYNT DFVTSFSSKAQLRTLPTTSLKDPSTELQKLSQIIRAHATKIGIIYHPDKFHGSISAACKE QYWLVCESSNTSLSEKAAEVTNPLEELDKLAKLIRAHTTKVGIVFKPETLIKSTDAAFNT EFWIQSITINQFNQITTTTIENPQQELIKLIKLIKAHTTKVGIIFKPSNLFKDPNVAYNT QFWIVSLNSEKISQVRAASVAKPLNELSSLVKLLRAHTTKVGIIFEPERLKKEPATAYST KYWL--TNLDNTTKSGNSKITDPIDELYKLIKLIKAHVTKVGIIFKPNNLKKDPNVAYNT DCWGLVSGSEGLKTIPPAKVQEPLKELVKVAKLIKAHTTKVGIIFEPSKLAQSSDAAYTT LYWSSAENAEEFSGIQAAKVNKPLDELLKLAKLIKAHTTKVGIIFKPENLKKDANPAFTT KYWRTSLATSEVTS-QTARLEKPLEELEKLAKLIKAHVTKVGIVFKPENL-RSVDAAYKT QFVEPYSESKHLREISTTSLQDPILELSKLAKIIKAHSTKVGIVCNPDKFYSNINPIFNE ------------------------------------------------------------ LKNYADSLFYLLSLLPLFTREQYASYLNEDVFTQVLGLLNGTEMLCDEI--CSSSKENEG MVELMNVVFYLLSLVPLFHDSHFADYFINKLDNDIVSLVQSIHKLSDELDPIIAEDEKAK IQSFSRSLFYLLSLFPLFYNNEYPKYFSDQIDESTLQLLDGLRNFIAELQKRLKNEDDAS LQELIKSIFYLLSLVPLFHKDPFTKLFLKKLDAQLLALISSLSMLIDEISKKLEETKS-- IQNFSRPLFYLLSLFPLFYNNKCPKYFTDQLDESTLQLLDGLRDFIAELQERLKNDENAS IQNFSKPLFYLLSLFPLFYNDKCPKYFTDQLDESTLQLLDGLRDFVAELQKRLKNEQDAS IQNLSTPLFFLLSLFPLFYRNKYPKFFIDQLDESTLQLLDGLRELVSELQTRLKNEEDAS IQNFSRPLFYLLSLFPLFYSDKCPKYFADQLDESALQLLDGLRDFIAELQERLKNDENAS ------------------------------------------------------------ LRALEESLFYLLSLLPSFHKSGYTSYLNKQLDEEILALLRSLEKFYDEI----------R LQAFTNSVFYLLSLLPLFYSSKYAEYLLDELDACLLGLLGGIGNLCDEIKNAKPLDTDPD LEELSETLVLTISIINQLENEQISKIFYDEIIDQIKLLFSSIIELNQELTNEDGEDNDDD LQLFTNAVFFLFSLLPLFYTGNYADYFTDALDANILGLLNGVQGLCDEITATTTAESKDS LQKLSESLVLIISLVSQLKSKIISDMFYKEILNSVRLLIESNSQFADELETQAPASHSEN LEKLSETLVLIISIIIQLENEQISKIFYDEIIDQIKSLFSSIIELNQELNDNDNDNDNDD LEKLSESLILTVSLIAQLKLQDISQLYYDEIVTQVAQLIESNHELAKELSKSESENESNG LEKLSETLVLLISLIQSFKIKQISKIFYDEIFNNVKNLIVSINQLSNELGDNDEDDREEV VSDLSKSFVLYMSVVAQLSPDKISSLFYKEILNSSHTLVSTAASLTAELSGKSSDDKKNT LLKLLETLILLVSVVVQLRPSEISQLYYDELLKGIKQLMDSNKELSHELNTENTPSKDSD VEQLSETVVLTVTVVAQLSPVEISDIYHSEILGLVKSLLSTTDTFAEELQESTSTETSDS LKNFTNSIFYLLSLLPLFYSNKYTEKFLQSLDDLILGLLNGVSLLSNELEDAQTNSKDKE ------------------------------------------------------------ DNKDRLISVGIIWASCDELCDIVKGGNYGLLSKRIALSCGLVDDVLEDIHGWLEDPQLED FLKERLISIGMLWSQCEHLELLSNQGNLGLLTEYLSSSVKLLQDSIEELEEWLEDPVINS LDKERLTSVGKIFNACDFLSNCSKIGPCGILANILKGNVDIMDDTLDEIKEWLEEPDSAN -DENRLMAIGLLWSVCDSLNDLTKKGNFGLLRDYISDSASMVDDTLTDIKEWLDDPQLED LDKERLTSVGKIFNACDSLSNCSKAGPYGILANILKDNVAIMDDTMNEIKEWLEEPDSAD LDKERLTSVGKIFNACDSLSNCSKVGPFGILANILKGNLAIMDDTLDEIKEWLEEPDSAT LDKERLTSVGKIFNACDFLSNCSKVGSYGILANILKGNIAIMDDTLDEIKEWLEEPDSAN LDKERLTSVGKVFNACHSLSTCSRAGPHGILATILKDNMAIMDDTLNEIKEWLEEPDSTD ------------------------------------------------------------ EKEENLVSVGKIWASCDELLALAEQGNLGLLNERLSASAKLVQDTILELHDWLAEPTLEQ HDDVRLISIGKIWASCDTFTKISSLGNLGLLNNKIQISSKLINDTLTEVEEWLEDPQLES DDAGRLISVGKIWSNCDSLDQLLNEGDLGLLTTKIKQSISLLDDGFEEFVTWANNPEIED EQDLRLISVGKVWASCDSLKELATLGNLGLLNKKISVSTKLISDTLSELEDWLLEPELEE GIDGRLVSVGKIWSNCDALSKLVKDGELGVLSKKIKQSIILIEDGLDEFEEWAENPDFDD DDSGRLISVGKIWSNCDSLDKLLNEGDLGLLTTKIKQSISILEDGFEEFVTWANNPKIED NGEGRLVYVGKIWSNCDSLSKLLSEGALGLLTLKVKQSIDLIDDGFEEFVEWAENPEMG- SDDGRLVGVGRIWSNCDALIKLLDEGAVGLLSNKIKQSILLLDDGFEEFKEWAENPQMDD EVDVRLISVGKVWNACDELVKLVENGNLKFLEKKTRLQLSLIEDGLDEFSEWAENPEFDV EMDKRLVSVGKIWSNCDVLISMINNGALALLTDKIKQSVLLIEDGFEEFAEWTENVEIDD KIDQRLVSVGRLWEHCDELIDLIKTGKLGLLNRRIKQSILLIDDGLDEFAEWAQDP---- ESGDRLVSIGIIWASCDNLDALAKKGSSGLLCENIHNNIDLLSDVLNDVNDWLEEPEFGD ------------------------------------------------------------ DFLGDDLDSIDELKKMGIDGDDEEMIEIVKKFLSEWQTKIKMIKLLLSSFSKSINIPNLG DPFGMNDKFSDEEGTDLDEEEEEEASESMIEFVKSLSQKSRLLKLLLSSLSKSIDTVTTA DMFLDFEDSESETEVKDEDFDQEKVYECIKLFFDGFTKKIKMIKLLVSIFRKTLPKKNQA NFFGDEEEEEED-ANPSDNEEDTKALERMEVFLKEWETNLKLIKLLLVSFKKSVATESNA DIFLDFEDSESESDSQKEEFDQEKVYENIKLFFDGFTRKIKLIKLLVSTFRKTLPKRNQA DIFLDFENSESETVNDEEDFDQEKIYESIKSFFYGFARKIKLIKLLVSTFRKTLPKKTQA DVFLNFDDSESETDAAEEDFDQQKVYESIKSFFDDFVKKIMLIKLLVSTFKKTLPKSIQS DVFLNFEDSESETEAEKEEFDQEKVYESIKSFFDGFTRKIKLIRLLVSTFRKTLPKKNQA ------------------------------------------------------------ DPFGLEDSFEETSESTATNAENKAPSPQMIEYVQTLERRVKLVKLLLKSFQKSVHTKAAA DPFGLDNSLSGDEEFNSGDEGEKQVLEQMVKFIKLWQNNLKMIKLLLSSFSKSISKEKDG DPFGFSDDEEEEEDNDNDSLHSIIDTKELSEFANKWVKKIELIKLLISSFKKSSPNSISG DPFGLDEYDSGAEEPESASEDSKKTLAEVVEFIKIWQQKLKLIRLLLSSFSKSITKEPLA DPFGFSDDESEEEEIPEKENGNKEGKENLIEFSQLWLSKIKLIKLLLTSVTRSLPSVTSG DPFGLSDDDEEEEEEEDNSLQSTIDVKELSEYSLIWVKKIELIKLLISSFKKSSVIPISG DPFGFSDDDEEEEEEEKSSETGLSDNDELSAYAKKWQKKIELVRLLLASFKKSLPKTTAS DPFGFSDDDDEEEDDRYVNEEPPVDNSEISKFALKWVKKIELIKLLISSFKKSIPKTTSG DPFGLDEFSEEDGGESTSSSAAEATMLKLSRFSKQWVQKFKLIKLLFLSINKSLPSIVNG DPFGFSDDEEESENKLEDDGENGEDVEELKKFAQLWLKKIELVKLLILSFKKSLPLSTSG ------------------------------------------------------------ MILGDDDDLEENMITSKTEDRKSLILEQMTQFMEEWQNNIKLIKLLLSSFTKSIKSSYKA ------------------------------------------------------------ SKLDELNKLHKQVILHLDELVSDVMSGAAFDEDMGPSIADLNDTLAKMVHIIKEISKQDP AYLSELNQLHNSIVSNSDTLISSTLVNAEYEVDVETSVLAINNDVKKVIKIITQLNGSDE VTLDSLHTLIKEAQLLLDEVVSTVFEPKKFSAQVKEEEAELAGVIRKTLVQMNKLYEGDA VLLDEFQELHSQLGLHIDDFISGVMSDASFQPNFDEDIETLNKDLTQIVKIIREINKKDP ETLDSIHTYLKEIQLLLDEVVSTVFEPKNFTNEVKEEQAALVAVTKKVLIQMSKLYEGDP SILDSLHTSFKEVQLLLDEVVSTVFEPKKFSAEVKEEQAGLSAVTKKALTQINKLYEGDA DTLDSLHLSFKEVQLLLDEVVSTLFEPKKFSAEVKEEQAALATVIKKALVQMKKLYENDV DTLDSLHISLKEIQLLLDEVVSTVFEPKNFSTEVKEEQAALAVVIKKVLALMNKLYEGDT ------------------------------------------------------------ DSLEKVYKVHHAVVEQIDELVSSVMLGADFDPQLLEGVKTLHSTMESMCKLVKKLNNNDP ESLTKLNQLHGATVAKIDDLISTAMLSQDFDPELKEIVEDLNDSIKKIVKIIKLLNRNEE NTIDEINNLQSNLVQLIDNFIIDLMIDRNIHDDIIRYTNRIINQAIKLSELAMIIYNHQP AQLSKLNELHQLVVEKVDELVSTVMASHDFKADILELTTVLNSSIQKIVQIIKTLNKGDD DIINNINDVQRLLVNKIDTLIVDLMMSKEVDEESVLNSQDITKICYKLIKIVKDVNKSND KTIDEINNLQLNLVQLIDNFIVDLMLDRNIHDDIIRYNKGIINQAIKLSELAITIYKNNE NQIDKIYDIQKSLVTSIDKLIVELMMNGEISDEVESIADDISNSSTKLAKLAESIHKDDT QLIDEINSIQLKLINLIDKFIMNLMLDTTIDDEILKNTKEITLQANKLSKIGISIHSTDD TDIDEIYNTESIISKEADLLIVELMMSHSLTEDVTEHSIAVDKACSKILSILKKANKNSD SSIDSIYAIQFGLVKLIDKFIVDLMLDRTIDGEIEEYTGAITKESVKLAKLARDIHAKNN ------------------------------------------------------------ TNLNSLETLHSQVIENVDELISDIMSDETFQKSFEENIQTLNKVLKDMVSVIKKINKTDP ------------------------------------------------------------ KKSKWIDVWNNKYFE----------------------------MSSKQYFEQLPKKLKDF SKLKWIQVWSNKWSS-------------------------MSGASMKHYFELLPVQLKNF KRKKWIQVWETKFNE----------------------------MSYKQYFDGLPLKLKSF ANSKWIKVWETKYFK---------------------------MSNAVKYFDQLPTKLKNF KRKKWIDTWEIKFNE----------------------------MSYKQYFDSLPLKLKSF KRKKWIEIWETKFKE----------------------------MSYKQYFDKLPSKLKSF KRRKWIEIWETKFNQ----------------------------MSYIQYFESLPLKLKSF KRKKWVEIWEIKFNE----------------------------MSYKQYFDSLPLKLKSF ------------------------------------------------------------ KKNAWVESWEAQWNK------------------------------MKQYFELLPPRLKEF KKGKWVEVWENKFFS------------------------------MKQYFDLLPRTLKTF KKLKWYETFINKISL------------------------MSFQLTPKEAFAKLPQKLHNF KKGKWIEVWDAKYFS-------------------------MSGVPTRQYFQLLPDTLKTF NKIKWCVAWDSKFKE--------------------------------------------- KKLKWYETFINKISL------------------------MTTHLTSKEAFAKLPQKLHNF KKTSWYSTWITKYDS-------------------------MSSLTAKEAFAKLPQKLHNF KKSKWYETWINKFII------------------------MASQLTSKEAFAKLPQTLHNF NKTKWCSSWEIKYKE--------------------------MSLSAKEAFAKLPQKLHNF KKAKWYEAWETKFRT--------------------------MSLASKEAFSKLPQKLHNF --------------------------------------------MSKDAFKHLPQKLHNF KKSKWIEVWELKYFE---------------------MRASPSVMNSVKYFEFLPSSLKTF ---------------MKPSVNMLKQAVSSAVKAQVPVIDASPSYIPNANFAKLPQKLQDF FYKYPP------------------SVKYAVKP-TSTHAMDA------------------- FKKYPP------------------NVKYSDKP-TLITAMDA------------------- FHRYPP------------------SIKYSSVS-TSTKAVDA------------------- FIKYPP------------------SVKYATKP-TSIFSPQA------------------- FQRYPP------------------SIKYSPVS-TSTKAINA------------------- FQRYPP------------------SIKYSSVS-TSTKAIDA------------------- FQRYPP------------------SIKYSSAS-TFTNAIDA------------------- FQRYPP------------------SIKYSPVS-TSTKAINA------------------- ------------------------------------------------------------ FKKYPP------------------SVQYSAKP-ELTSSPTA------------------- FKKYPP------------------NVAYSGKP-TSTTSPLA------------------- FIKYPP----------------RPFAQYKDGP-STTTDPLR------------------- FKKYPP------------------GVKYSSKP-TSTHAIDA------------------- ------------------------------------------------------------ FIKYPP----------------RPFAQYKQGP-STTDDPLR------------------- FIKYPP----------------RPFAQYKDGP-SLTTDPDM------------------- FIKYPP----------------RPFVQYAAGP-SKTTDPMK------------------- FIKYPP----------------RPFAKYAEKP-STVNDPHM------------------- FIKFPP----------------RPFAEYSEKP-STIVDPKF------------------- FVRYPP----------------RPFAQYSSSP-STLDKPEM------------------- FNKYPP------------------SIKYATKP-VSTYDVVA------------------- FQRFPP----------------QPFVNYSAKK-GFKDAPNA------------------- ----------NPFLANKHPVTGKYHGAKYSARRMSDIYKLAYRYGVQDLLPQ---TNKQF ----------NPFLPNKNPATGKYHEPKYSLRRMSDLYKLAYSYGIQDLLPP---SKKLF ----------NPFLPNKHPVTQRLHDPKYSLRRMSDVYKLALRYGVQDFLPPIDNTKKLF ----------NPFIANRNPITGVFHSPRYSLRRLSDVYKLAKRYGIEDMLPSQGRTKKLF ----------NPFLPNKHPVTQRFHDPKYSLRRMSDVYKLALRYGVEEFLPPIENTKKLF ----------NPFLPNKHPVTERFHDPKYSLRRMSDVYKLAVRYGVQEFLPPIENTKKVF ----------NPFLPNKHPVTQRFHDPKYSLRRMSDVYKLALRYGVEDFLPPIENTKKLF ----------NPFLPNKHPVTQRFHDPKYSLRRMSDVYKLALRYGVEDFLPPIENTKKLF ------------------------------------------------------------ ----------NPFLPNKNPVTGKYQEPKYSLRRMSDLYKLAYNYGLQDMLPP---RKKLF ----------NPFLPNKHPVTNNHHNPKYSLRRMSDLYKLAHQYGVHKFLPA---TNKLF ----------NPFFPNKNQESGNWQSAKFSRRRSADLFKLAKKFGIHDLLPP---TPRKF ----------NPFLPNKHPVTGRYHNPKYSLRRMSDLYKLARQYGLHELLPP---RNKLF ------------------------------------------------------------ ----------NPFFPNKNQESGNWQSPKFSRRRSADLFKLAKKFGIHDLLPP---TPRKF ----------NPFYHTKNPDTGKWRGAPISRRRSADLFKMAKKFGIEDLLPP---VPRKF ----------NPFFPNKNPETGRWQEPKYSRRRSADLFKMAKKFGIQDLLPP---TPRKF ----------NPFLPNKNTDSGRWHGAKYSLRRSADLFKMARKFGIQDLLPPIPH--RKF ----------NPFLPNKNPETGKWHGAKYSLRRSSDLFKMARKFGIQDLLPP---MPKKF ----------NPFLPNKNAQTGRWHGPKYSLRRSADLYKMAYKFGIADLLPPIPH--KRF ----------NPFLPNKHPVTGRYHEPKYSKRRMSDLYKMAHSYGIQEFLPP---MNKKF ----------NPFLPNKSRVTNKTHKPLYSLRRQSDLYKLAHKHGVHELLPP---MEKTF FEEKYNNKKFMRGILTP---KGHKHELNMEERMKRK----AEGIANAEKILAEVKGSKYK FEEKYENKKFMKGVLMP---KGHKHERLLEGKVAKM----EEAIKNADKYILEAKGSKYK FEDKYDKKTLMKGVLLP---KGHKHELKLNEKLKKR----EEALKNVDNLIASKKGSKYA FEDKYENKKFMKGVLLP---KGHKYELQLVAKKVKM----AKGIKDADKTILNVKGKKYA FEEKYNKKTLMKGVLLP---KGHKHELKLNEKLKKR----EEALKKVDELIASKKGSKYA FEEKYDKKTFMKGVLMP---KGHKHELKSNEKLKKR----EEALKNIDDLIASKKGSKYA FEEKYNKKTLMKGVLLP---KGHKHELKLKETLKKR----EEALKKVDDLIASKKGSKYA FEEKYNKKTLMKGVLLP---KGHKHELKLSEKLKKR----EEALKKVDDLIASKKGSKYA ------------------------------------------------------------ FEEKYEQKKLTKAIVFP---KGEKHERTRSQRMAEM----EEAIKNADKFILEARGAKYA FEEKYKQKKLMKGVLLP---KGHKHELAHDEKLRKM----EEAIKNADKYIVEVRGSKYA HEDKYTNKSWLHGMINP---ASKAKQEELDAKLKAR----AEAIANMDNIIVATRPS-YK FEEKYQQKKFMKGVLLP---KGHKYELAYQEKMQKM----RDAIKNADEYILEVKGRKYK ------------------------------------------------------------ HEEKYNNKVWLHGMINP---ASRGKQEELEAKLKAR----AEAIANMDNIIVATRPS-YK YEEKYDNKKWMLGMTHP---ASAVSKPEIEEKLRKR----AEAIKNMDKIIVAARPS-YK HEDKYQNKIWVQSMVNP---VDEVKAAEYEARMKAK----EEAIANMDKIITEVRPS-YK YEDKYYQKNWMRGVLNQ---KKQKWERELPEKLKNR----EEALAKMDETIIAARPT-YK YEEKYNNKNWMRGVLTQ---KKQKWERELPEKLEAR----EDAIAKMDDIIAAARPR-YK YADKYENKNWMRGVLFQ---KKHKWERQLPEKLAQR----AEAIEKMDDIIVEARPT-YK FEEKYDKKTFMRGVLTP---KGHKHEFARQSKLAKM----EVAIKNADKYILDVKGRKYA FETRHEQAKPLIGEMVW---KKHIREKTKESRKEKI----AKALETMDEKIAEAKGKKHW RR---------------------------------------------------------- RR---------------------------------------------------------- KK---------------------------------------------------------- AR---------------------------------------------------------- KR---------------------------------------------------------- KK---------------------------------------------------------- KR---------------------------------------------------------- KR---------------------------------------------------------- ------------------------------------------------------------ RR---------------------------------------------------------- RK---------------------------------------------------------- KL---------------------------------------------------------- NK---------------------------------------------------------- ------------------------------------------------------------ KL---------------------------------------------------------- KL---------------------------------------------------------- KL---------------------------------------------------------- AQ---------------------------------------------------------- RQ---------------------------------------------------------- KQ---------------------------------------------------------- KK---------------------------------------------------------- ER---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MEKVQEKKRVG-WV---------- ------------------------------------LEKKQNQNTRS-WF---------- ------------------------------------LEKMKTTQSIG-WF---------- ------------------------------------LERKSKENQRN-WV---------- ------------------------------------VEKMKKNQSIG-WF---------- ------------------------------------LDKMKKTQSIG-WF---------- ------------------------------------VEKMKKNQSIG-WF---------- ------------------------------------VEKMKKTQNIG-WF---------- ------------------------------------------------------------ ------------------------------------LERKKEKE-RT-WF---------- ------------------------------------LEKKKRGNVNT-WF---------- ------------------------------------LEKREKRK-KT-WF---------- ------------------------------------LEKRKQEKSPR-WF---------- ------------------------------------------------------------ ------------------------------------LEKREKRK-KT-WF---------- ------------------------------------LKKQKERE-PK-WF---------- ------------------------------------LEKREKRK-KT-WF---------- ------------------------------------LKKKQKKQ-RT-WF---------- ------------------------------------LEKKKKRE-QT-WF---------- ------------------------------------LKKREQKK-RT-WW---------- ------------------------------------LEEKKKYDKVT-WF---------- ------------------------------------LERREREK-KQ-WV---------- --------------------------------------DYTKLLVARYLEENGFTNTLSA --------------------------------------QLTKVLVGQFLEKNGFTDSLAS --------------------------------------FYTNLLVAKYLKHNGLEDSLAA --------------------------------------KYIEALVAQYLKKNGFEETLSS --------------------------------------FYTNLLIANYLKHNGLEDTLAA --------------------------------------LYTNLLIANYLKYNGLEESLTA --------------------------------------YYTNLLIANYLKYNGLEDSFAA --------------------------------------LYTNLLIANYLKRNGLEDSLTA ------------------------------------------------------------ --------------------------------------GSVKVVVAQFLQKYGYQKTLGH --------------------------------------GLTKVLIAQYLKKHHYDNTLSN --------------------------------------THIHKLIADYLKENNYLETLKQ --------------------------------------ALSKVLVAQYLAKHGHEATLLN --------------------------------------MNIETHIAQFLKENNYPETLKA --------------------------------------THIHRLIADYLKENNYLDTLRQ --------------------------------------TVVHELVAHFLKENNYVDTLDQ --------------------------------------TYIHNLIAQYLQDNNYPETLKQ --------------------------------------MSVHSFVAHFLKDNGYLETLKT --------------------------------------NSVHSLIAHFLQENNYHDTLKQ --------------------------------------MSTHSFVAHFLKQNNYLETLKA --------------------------------------RYVKVLVAKYLKDQGYHTTLND ------------------------------------------------------------ FLDETDLSLVDLNNVAMKLTELVKDRIKFDEQLLLKKERADNE------FPLTKWNTFKC YLRESGVSMTSVKQTEDDLEDIIKDRVGFNEQAVVQKLVSLNSELDPTKFTIPSWLAWEE FIKETALPFSALEESKESLQSIIQDRICYKNSSFQDRFLSVNDDLAPAKYGIEPWLKFSL FLKEASLPLAVVDDKEDDLETIVADRIKFNEHSLALKMLKLNDNISESVALFKSWVKFTS FIRETALPLSALEKSDEDLQSVVEDRIYYKRRSFKDRFLSINDDLAPAKYGIQPWLKFSI FIKETALPLSALEESKESLESIIEDRIHYRKSSFKDRFLSINDDLAPAKYGIQPWIRLRI FIRETALPLSALEKIKEDLQTVIEDRIHYKKLSFKDRFLSINDDLAPIKYGIQPWLKFSI FIRETALPLSALEKTKEDLQSVIEDRIYYKKLSFEDRLLSINDDLAPAKYGIQSWLKFSI ------------------------------------------------------------ FLNEAGLSLGALQSGDEDLETIIGERTQYLERARNDEP----SQLDVACEQLPRWVQWAA FLIETSLPLSAVDDHYDDLETIVTERVQFNEHEVSERLLTINDSLPSDKFHIPCWTKFTA FENEHGNPIPATKLLDESLSDIINDRIQYNTLLDDNKTINVNDELAPITQQFSNWTPFPH FLQETGLARSTVEAAHEDLETVIAERIAFNEHAIVSKLTSLNDAIPAKRFQVASWQKLVQ FEREYGKPFSVSPN--ESLQSIIEDRYNYKALNAQTKDTPLNDELNALNNQVNEWVPYPK FENEHGNPIPATKLLDESLSDIINDRIQYNTLLGDNKAINVNDELSSITQQFSNWTPFPR FEKEHGKQIVSNALNEESLELIVEDRLNFNLLQDRLKNTGIYEELPVVSERFESWVPYPH FENEHGTAIQPSKLLDESLDEIIDDRIQYSSLLDKIEAIDVNEELHDIKDEFNHWTPFPQ FEAEHGKQITTELPHDESLTDIITDRLKYLSTEPQVQDKILDEELRSKEKQFKEWVPFPN FEEEHGKPIEALKLPTESLEEIVNDRINFNELNAQFEQVDLHEELTAAAQQLEHWVPYPQ FEKEHGSPISTETGHDESLDQIIQDRVSFSKDFEI---LSLNDANQAVDQELPNWTPYPS FIKDAELSVNLVDSCNESLRHLVQDRFHYNEHLISNKFLNLNDSMPKLKEILPSWLQFNF ------------------------------------------------------------ EELE-QSKSLPVTAKLPTKEYLLISKANKTTTVMKWESNNIIQHDNICKEIGYFGTNCCY VVSTSEQRSLVIKTKFLTDNLLACATVDKKLIVSDNVTVDSISQPGIIKYFGPITEKFHY DLNLNPKDTLFISAKFIDDDYLLLSSATGELTIYDKVLKVNEVVKGIVKLCGSIRSGYHY VLKR-ELNALTIAAQFCNDNEIILSMSNREILLYNSKLSQPSNNAGISKLCGTFNSSYYY DVKLNPKDTLFISATFTEDSYILLSSATGYLVIYDKSFKINEKVKSIVKLYGPISSGYQY NISLNIKDIMFISANFTGDDYLLLSSATGDLTIYDKTLKMKEKVKGIIKLCGSIISSYQY NVNLNPNDMLFISAKFTEDGHLLLSSATGCLIVYDKALNIKEKIKSIVKLYGYISSGYQY DVKLNPKDTLFISTTFTEDGYLLLSSATGDLVAYDKSFKINEKVKSIVKLCGSISSGYHY ------------------------------------------------------------ ARELQGANGLVIS--ADLSGQPVLATSSREVLQYGQLEKRSVSSIGCIRKFGWFGSRERY FRGFQPPVGLTIESCFCYNSTLLACTSTKQLHFYDLTQKKVLKLDNVIKRCGMLTDIYYY QPSKLDIDGLVISSCHDKKNLIYLSSNDCKIYVIK--IIHTLKMPVVIKKILTINSDKMV QPLLEKVPGMAIDVRAETDASLAVSTSARSVCFYDHILKELKSTTGPVKKCGALDPKFYY DPKLVSIDGLVISSCFNENTILFLGTSKTKLYVINLLESTGFIGKCVIKNITIASDNKLV QPSKLDIDGLVISSCHDKDNLIYLSSNDCKVYVVK--IVHVLKTPVVIKKILVIDSDKVV VPHALDTKSLIISSAYDPYNSVYFSSNDSKIIIVKGVVVKTERFLEIVKKVLVVDETKVA TPRKLDIAGLVLGSC--YSQLVYFSSNDSNVHVVKDIICKTIKMPVVIKNILTVGDDKII VSHEIKIDDLVIDSAFDNKNYLILATSARELVVVDVFRRKNVIGDVVIRKIAVT-SNAVV SIELLQISALAIDLALDKENLVFVSTNDFRLVVIELLNAANVLKKVVVKKILVLPKQRIV TKYKLEVTGLTISAAIVTDK-VIASSNDGSISIYDLSRKERFLGGVVAKSVVSVGKNDVL SPLTNCPSSLIIHSKYCHITQLMLSTSDKEVIIYDKIGELISERPSISKLCGSINDRLLY ------------------------------------------------------------ FISIDGKLVTLNTTMLQ--TFPLNTRMVSHAKIINIKGRWYLSYCGLDSKLRVAEIILKQ TGTIDGKVNIVDGVNSQSWSFNLPGRAVMAMEMVLEDGKILCFYCSLNNTINAYVYNLET VCPMNGSFYLNNFEFITDAVWKIHSRMITHIKICFTESSWFIISSGMDNLLKLSILEVQD ATSMNGMLTLATGAFIDNATWKIHDKMITHIKIWKCNMVWYVISTGLDNCLKLSCLNLPK VCPMNGSFYLNDFELVNNAVWKIHARMITHIKICVTESSWFVITSGMDNFLRLSLLEIKN VCPMNGSFYLKKFELITNAAWKIHERMITHIKICFTESSWLIITTGMDNFLRLSLLEVKD LCSMNGFFYLKDFELVPNAAWRIHTRMITHIKICATASSWFIITSGMDNFLRLSLLEIKD VCPMNGSFYLKNFEVMPNGVWKIHARMITHIKICVTESSWFIITSGMDNFLRLSLLEIKD ------------------------------------------------------------ ALGMDGSLALLGADGVPLRSWRLHGRMITHAAFFTTERKILCFTYGLDGYIRLHEFDEEM VCGIDGSVSMNSLEPIAGFKWRLHNRVITHVQWFRGRGELLCFSCGLDGFIKMHSLNLSD LVGMNGILYLERGTLEEIDQFQAHKRLIVDAKSITFQNRNYLITLGWDFHLRLILLNENN ACGFDGTISIAKFER--AIHHQLHARIVTDIDFWDSNTRFQIFSCGLDNYVKLHILDLNT LLGMNGKLHLETFEIKSIDELQAHPRLIVDTKSIQFNNDTYVFTLGWDFTLKVFTVRDR- LVGMNGILYLEKGKLQEIDQFQAHKRLIVDAKSIVFRNQKYLITLGWDFHLRLIMLHSNR LIGMSGTMYLRSGSLELVSEFSTGSRFIVDAQHIKYKGVDYIVLLAWNNVLKLFKIGKDK LVGMNGTLYLHSENLDPISEFQAHKRLIVDARYKRVGNVDYIVSLGWDFFVRLIKLDEEN LCGMQGKAFLGMSELNIEAERQIHARLVVDVKVVSWREQDYLVSLGWDYLVKVFKIEDDD LVGMDGKFYNGSVTLTKSTEFQAHKRLVVDAKYIQFDGEEYIVSLGWDFFIKVFKIVKDG IVGMNGNIYLEGDELVKLFDLALHKGLVVDCGYAEVNQNRYFVTIGWDKMVKLVKISKDK TCSIDGTFYLNDFKSLECQNNKLHMRMISHLKIIDIGNSWFVISCGLDNSLKIHVLSKVN ------------------------------------------------------------ LNILNQVQLLSKCTAIEATPETGDPVIFVSRFEYSSILVFCMTQATILHLSNIALNDAQF TSKVSEYKLLSVCTALQLASEDGCPVLFLARQDFTQIMIFKFRNHQIHHVANIALNTAQF FKQLSDIKLASNCTSLNVIDGHTKFSVFLTRADFTHIACYAISDSTLVHSYNIALNNTEF LKTTCEEKLSSSCTALELQILVRKPMILITKEESTQLSCFTVATSKLELLYNLALNNTQF LTKLSEIKLASNCTSLNVINGQNSFSVFLTRAEYTHIACYSIIDANLVHSYNIALNNAEF LKQLSEIKLASNCTSLNVINGRKKFSVFLTRAEFTHIACFAISDEKLVHSYNIALNNTEF LTQLSEVRLASNCTSLNVIDGRNKFSVFLTRAEFTHITCYSIKDAYLVHSYNIALNNAEF FTQLSEIKLASNCTSLNVIGRRNSFSVFLTRAEFTHIACYSIIDANLVHSYNIALNNAEF ------------------------------------------------------------ PKSMDEYKLVNSCTGFQLATDDDEPTLYYTREDHTHLFVLQVHDLKLQEVYRIALNAAQF ITLLHEVKLLSACTSFQLATESGDPVLLLTRLDFTQVMVFVVSQNRLVEHSKIALNNAQF FEILSELKLKQQGSCLDVTVYQDQLVIILGKTENTLLDVITMKDSELTLVHKISLNDAEF IELAGSQKLLTPCTSFQLASESNFPVLFLTRADFSHVLVFGAVQNRLVEICKIALNSAKF FTPITQYKLSTQGTSFDVTVFADKITLVVGLNETTLLSVFHLIETDLVLLYKISLNDAQF FELWSELKLQQQGSCLDVTVYQDQLVIVLGKTENTLLDVITMNNSELTLVHKISLNDAEF SKLVSEMKLNQQGTCFSVVEYQGQLVLVLGKLESTLLEVYTLQDDEFQLRYKISINDAEF FSLLSELKLQQQGSCIDVVEYQNELVIVLGKLENTLLDVLAIRDNQLTLLYKISLNDAEF ICPVGEFKLANQGSCMDACVYKDRITVLVGKSEITLMDVLCMGEEKLSLDCRIALNDAEF FEVTSEYKISSQGTCFDVVEYNKELVIVVGKNENTMLDVFVLDKRELAYIYKISLNDAEF IEEIATYKSTLAGTCIGVCGYNGSVIVVLGRTESTLLDVLALSENEMVPVYKISLNDAEF FKLLNECKLSSQVTSINVSEHTLIPLIFITRSEYTHILCYTF-DNSVSLLYQIALNDAQF ------------------------------------------------------------ MSHSFHGLDMTINENASNSQIVVATSHTPFMRLIVINLGDIWKEIFTSYNSIILNMLTNI STHSFNVSDMLITSFTPSTILAVATSHIPYMRIIVTKVYTVEDLSKTHYDSILQNIATVV STYAFNIRDAIVADFVNSSMLVVATSHKPYMRLLLVEIHSESMESKTYYDKVLRNFATEI TSHSFTVRDMVTLDKSLLKYLAIVTSHVPYMRLILVRLLQDRELRTTLYGNIVANMVTKV STYAFNIRDVMAVDYVHSTMLVVATSHKPYMRLILVEIHPKAMKLQTYYDKILRNFATEI STYAFNVRDAIVVDFVHPTMLVVATSHKPYMRLLLVEIHSESMEPKTYYDKILRNFATEI STYAFNVRDVIVVDFVHSTILVVATSHKPYMRLILVEVQLKWIKSKTYYDKVLRNFATEI STYAFNIRDVIVVDFVHSTMLVVATSHKPYMRLVLVEIYSMSMELQTYYDKIIRNFATEI ------------------------------------------------------------ STHSFSVRDMIVVNFEHISVLIAATSHTPYMRLIFVELLPVSSGVKVYYDKVKRNIATPV STHSFNVRDMVLLDFENTTMLAIATSHIPYMRLILTEILGTSQKVKVYFDKILRNIATTI TAAGFSPRCLMIENSGHVPLIAVGTSHEPYMRLIIVPLQDLANEPSIKRNQIIKNLNTMS SAHSFNARSTCLIDFGAKSMLAIATSHTPFMRLILLSISGLTNEEIVHYDKIIRNMATCI TLSTFSPRCISIQSLPLGPLIAVATSHEPYMRLIIVPLKDSTAKGPIERDQILKNLSTLS TAAGFSPRCLTIENSGHVPLIAVGTSHEPYMRLIIVPLRDLSHEPSIKRNQIIKNLNTMS TASSFSPRCIIVTPSRDLPLIAVATSHEPYMRIIVVSLFGAASSASISRNQIVRNFNTLA TAAGFSPRLLTIHQAAI-PLIAVATSHEPFMRLIIVPL----SEAAIKRNQIIKNLNTLS SAAGFTPMCVRIHQSGENPLVAVGTSHEPFMRAVIVTLVGIAAQETVQRNQIIANLNTLS SSSSFSPRCLTIQYFHDSPLIAVGTSHEPFMRLIVVSLIDRNAEQPIKRNQILKTLNTLS MANGFTPRCISIAQGKTKPLIAVATSQEPFMRVIIVSLSKEAIESKVRRGQILTNTNSMA TSHAFNIRDVLILNTISTTMISVATSHTPYMRLLLATVLKGIDSGKTFYDKVILNMATEV ------------------------------------------------------------ PQDSYSQPILEWSDREKGLIVGSNDGLYAVDLSKNDSWQLSTFANRRIKLL-TSDHLLVV PQDSYSQPILQVSYSLGGLVVGADNGLYAVDLRKSDTWPLKYGKEDRIKSLDIYKDSICV SQDDFSLPILQKLKTSNGILVGNDEGIYSIDLMNGDSRLLKISLRSRIKCMDVSGDRVVA GQDGYSQPILKKLEQLNGLVVGANDGLYAIDIANGDSWRFRTFKHDRVKCLDVNQDMIVV YQDDFSLPILGKLESSNGVLVGNDEGIYSVDLMTGDSRILNISLHDRIKCMDISKDRMVA SQDDFSLPIIRKLKSSNGILVGSDVGIYSIDLMNGDSRLLNISLRHRIKCMDVSEDKVVA GQDDFSLPILRNLKYFNGILVGNDAGIYGVDLMNGDSRLLNIILRNRIKCMDVTNDKVVA CQDDFSLPILRKLDSSNGILVGNDEGIYSVDLMTGDSRLLNIFLHNRIKCMDVSRDRVVA ------------------------------------------------------------ PQNLYSQPILALCTVSSGLLVGADDGVYAVDLHLGNTWKLALNGNERVKAMALHDDFLLV PQDSYSQPVLRSFLKGRGILVGGDLGIYAVDVSKGDSWIVKSVGESRVKSLDVHDNRIVV PQDRYSQPIIAWRNKASGVWVMGDDGTIGIDIVEDQVIVELKGHQGKIKDFITFIDKLIT PQDQYSQPIVKPFTQANGLIVGSDTGVFGADLRNCDFWRII-SEEKRVKAMDVLNGQIAV PQDKYSQPIIRWKLKNNGVWVVGEDGTIGIDLIQERVITNYQKHDGRIKSFTLAGDRLIT PQDRYSQPIIAWRNKASGVWVMGDDGTIGIDIVEDQVIVELKGHQGKIKDFITFIDKLVT PQDKFSQPKIAWRNEGKGLWVMGDDGVMGLDVVESKVVVELKGHSGKIREFIAYIDNVIS PQDKYSQPIIAWRDRASGVWVMGDDGVIGLDIIDDKVVIELNGHQGKIKDFISFIDKLVT PQDKYSQAILDWRPDGTGLWVLGDDGVIGIDLSSGKVSAELSGHEGRIKTLNVLTNLLVS PQDRYSQAVVTWRGKSNGVWIVGEDGIIGIDLVEEKVQVELQGHTGKIKGFISFLNVLIS PQDKFSQPLICWRPHASGVWAFGEDGIICLDVKKQQVVAAIDGHKGRVKCVAMGTK-MVT AQNSYSQPIMKYLPQKKGIIIGTDNGIFAMDVRNGESWNLIKYKEQRVKTLEVAPEYVIA ------------------------------------------------------------ GTADKALFSCS-----------------------------MVVTTEAVT--SRSERDAEP SLASKKLVMWK-----------------------------------MSA--TNGSPEG-- GTSNKSIYMLN-----------------------------MPAENQNTI--QERSSNNIS GMADRSIYELA----------------------------MPAPPTRDRE--ITNVPLTTT GTSTKSIYILN-----------------------------MPAENQNTG--QDRSSNSIS GTSNKSIYMLY-----------------------------MPAESQNTI--QERSSNSIS GVSTKSIYILD-----------------------------MPVENQNSS--QERTSNNIS GTSTKSIYIIK-----------------------------MPVENQNIS--QERSSNSTS ------------------------------------------------------------ SLSNKTVFIWE-----------------------------MPDHEVQTR--KSRMLDDA- SFANRALAVWE----------------------MHPLSSRELSEENGQE----------- SGIDREIVTWR------------------------------------------------- SYAGGDLELWH--------------------------------MSDDEE----------- CGTDKLVYQWV------------------------------------MS----------- SGIDREIITWK------------------------------------------------- AGLDRQIIRWS------------------------------------------------- SGIDREIIEWK------------------------------------------------- CGTDRHIFKWT----------------------------MYVLLLPDCM--DQSKYTITT SGLDKDIKRFT------------------------------------------------- FGADKKAYRWT------------------------------------------------- AMANKQTNLYY----------------------------MSLDPDKGN------------ ------------------------------------------------------------ VQEPLVEKLATEE--------------------------------LNILVAVRCRGRNER -------------------------------------------DELNITVAVRCRGRNEK NN--LNAQIGCHGVP---------------------------NEELNITVAVRCRGRNER REPPEE------------------------------------DTELNITVAVRCRGRNER KN--GNSQVGCHTVP---------------------------NEELNITVAVRCRGRNER SNGNGNNQMGCHSVP---------------------------NEELNITVAVRCRGRNER KN--GNSQIGCHTVH---------------------------NEELNITVAVRCRGRNER KN--GNAQIGCHNAP---------------------------NEELNITVAVRCRGRNER ------------------------------------------------------------ ------------------------------------------QEELNITVAVRCRGRNER ---------------------------------------------LNITVSVRCRGRNER ---------------------------------------------SNIQVVVRCRGRNSQ ---------------------------------------------LNITVAVRCRGRNEK ---------------------------------------------SNIQVVVRCRGRNSR ---------------------------------------------SNIQVVVRCRGRNSQ --------------------------------------------MSNVQVAVRCRGRNQL ---------------------------------------------SNIQVIVRCRGRNSQ AISCTAHINNISSSIMS----------------------------ENIQVIVRCRARSKR ---------------------------------------------SNIQVAVRCRGRNDK --------------------------------------------MSNIQVVVRCRGRNER ------------------------------------------GDELNIIVAVRCRGRNER ------------------------------------------------------------ EIKAKS-SVVVDVP---DNGVTNEVSINTT------------DDVGIAAKMNSK--TYTV EIKAKS-SVVVNCP---DVIGANEVSINTS------------GDIGITARMNSK--TYTV EIGMKS-SVVVNVP---DITGSEEVSINTT------------GDTGITAQMNAK--RYTV EINSKS-PVVVTVP---DITGAQEISINTT------------GETGITAQMNSK--TYTV EISMKS-SVVVNVP---DITGSKEISINTT------------GDTGITAQMNAK--RYTV EIGMKS-SVVVNVP---DITGSKEVSINTT------------GDTGITAQMNAK--RYTV EISMKS-SVVVNVP---DITGSKEISINTT------------GDTGITAQMNAK--RYTV EISMKS-SVVVNVP---DITGSKEISINTT------------GDTGITAQMNAK--RYTV ------------------------------------------------------------ EIKAKS-SVVVTVP---DVTGSNEVSINTT------------DEVGIAAKMNSR--TYTV EIKAKS-SVVVTVP---DVTGSNEVSINTT------DELGITAQMNS------K--TYTV EIAAKS-PIVVELTNDNYSITEPYITINQGYTRATATTTTNNTTTTN------R--TYKF EVKARS-SVVVAVP---DVTGTNEVSINTT------------GDTGITAQINSK--TYTV EVTAKS-PLIVDLPNDTYSVSNPTITVNQD-----QQFSTFINSMNS------K--TYTV EIAAKS-PIVVELTDDNFSISEPYITINQGYTKATTTTTNVSTTNTT------R--TYKF EISAKS-QIVVELADDNYSITEPYVTLTHS------------PTSTPTSTSLGK--TYKF EITAKS-PIVVELSNDNFSITEPYITLNQP----VRATSPSLENGQK------R--TYKF EVAANS-PPVIELPNDVFSAQEPYVGVSTD---QPSLLSARSSFPGG------K--VFKV EVAAKS-PIVIDLPNDTFSVTDPYVSINHN------YTTQTVSSFNY------K--TYKV EVKANS-PVVVEMPVETYSVTNPTVTLCAN------------SESPSHLSSSFK--TYSV EIKAKS-SVVVSVP---DVAGSSEIAINTT------------EDVGIAGQMNSK--TYTV ------------------------------------------------------------ DKVF--------GPSASQKLVYEEIAEPLFQDFIKGYNCTILVYGMTSTGKTYTMTGDEK DKVF--------GPSADQSLVFKEIADPMFHDFIKGYNCTMLVYGMTSTGKTYTMTGDEK DKVF--------GPGASQDLIFDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEK DKVF--------GPAADQDLIFQEVAEPLFRDFVKGYNCTVLVYGMTSTGKTYTMTGDEK DKVF--------GPGASQDLIFDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEK DKVF--------GPGASQDLIFEEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEK DKVF--------GPGASQDLIFDEVASPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEK DKVF--------GPGASQDLIFDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEK ------------------------------------------------------------ DKVF--------GPSADQSLIFKEIAEPLFDDFMKGYNCTVLVYGMTSTGKTYTMTGDEK DKVF--------GPSADQSLIFKQIAEPLFDDFIKGYNCTVLVYGMTSTGKTYTMTGDE- DQIY--------GSQADQNLIYSQIAHPLLLDFLRGINVTVLAYGQTGTGKTYTMSGMD- DKVF--------GPSADQLLIFKVIAEPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDE- DQVY--------GSQADQLLLFDKVAMPLFNDFINGFNVTILAYGQTGTGKTYTMCGNCN DQIY--------GSQADQNLIYSQLAHPLLLDFLRGINVTILAYGQTGTGKTYTMSGMDN DQIY--------GSQADQCLIYSKLAQPLLKDFLNGLNVTILAYGQTGTGKTYTMCGDCD DQIY--------GSQADQSLIYSQIGHPLLSDFLQGINVTILAYGQTGTGKTYTMSGLDN DQVY--------GPNADQQLLFENVALPLFDDFVKGLNVTILAYGQTGSGKTYSMCGDL- DQVY--------GSQADQNLIFEKVALPLFNDFLQGSNVTILAYGQTGTGKTFTMCGGEQ DQVY--------GSQADQSMLFHQVALPLFHDFVAGYNTTVLAYGQTGTGKTYTMCGDLT DKVF--------GPSANQRLIFEEVAEPLFNDFIRGYNCTVLVYGMTSTGKTYTMTGDER ------------------------------------------------------------ LHNGE---LGDA--AGIIPRVLFELFDTL---EAN----KDDYLVKCSFVELYNEELKDL -LY-DGE-LSEA--AGIIPRVLFKLFDTL---EVQ----ESDYMVKCSFIELYNEELKDL -LY-NGE-LSDA--AGIIPRVLLKLFDTL---ELQ----QNDYVVKCSFIELYNEELKDL LYQ-NGTMLSDA--AGIIPRILFKLFDTLSDVTGS----TTDFVVKCSFVELYNEDLKDL -LY-NGE-LSDA--AGIIPRVLLKLFDTL---ELQ----QNDYVVKCSFIELYNEELKDL -LY-NGE-LNDA--AGIIPRVLLKLFDTL---ELQ----QSDYVVKCSFIELYNEELKDL -LY-NGE-LSDS--AGIIPRVLLKLFDTL---ELQ----QNDYVVKCSFIELYNEELKDL -LY-NGE-LSDA--AGIIPRVLLKLFDTL---ELQ----QNDYVVKCSFIELYNEELKDL ------------------------------------------------------------ -LY-DGQ-LSDS--AGIIPRIMFKLFDAL---EAT----DSDFLVKCSYIELYNEELKDL -RLYDGE-LSDA--AGIIPRILFKLFDTL---ETQ----DEDYLVKCSFIELYNEELKDL --------NNNKDIAGIIPRLLGELFQNLSSNATS----KNDYMVKISYLEIYNEELIDL -RLYDGE-LSEG--AGIIPRVLFKLFDAL---SAQ----GDDYMIKCSFIELYNEELKDL TEDAVGK-LNEM--AGIIPRTLNELFKSL---ESD--SGANDYVVKCSFIELYNEDLKDL NNKLDE--SSEI--AGIIPRLLGELFQNLLSNTTT-----TDYMVKISYLEIYNEELIDL LDIEFNFVMPEN--AGIIPRLLWELFGKL---TFE----HTDFMVRISYLEIYKEELIDL NNVLDE----NSDIAGIIPRLLFELFEKLNKLEHE---NKQDYMVKISYLEIYNEELIDL --------EGEH--AGIIPRVLSRLFSVL----------NGDYMVKLSCVELYKEELRDL KNSNVD--YKHSETAGIIPRVLIELFNKL---EPE--GAASDYVVKCSFLELYNEDLKDL HEK-HGSRLSEE--AGIVPRVLTELFTAL---DAN----NSDYSVRCSFMELYNEEIKDL -LY-NGE-LSDS--AGIIPRVLFKLFDAM---EFQ----NDDYIIKCSFIELYNEELKDL ------------------------------------------------------------ LDSTNTATNSDN--------KKLRIFDSNVNGDNMLRRKLGRHNTTGNSKISNNNHNFSR LDDGQDSGG--------NNSRKLRIYDSLNSSNNNSRSSSRSNSPTVNLEAKRRIRAALY LDNNSNNSSNNGFEG--PFMKKLRIFDSNTANLNKAALLRKRLRTKSLPNTIKQQ--HQQ LNYDSNDEQQQQQQ---LGSRKLRIFDSTNNNNNASSRASSRNNSPRTSSILPNANANLA LDSNSNGSSNTGFDG--QFMKKLRIFDSSTANLNKAALLRKRLRTKSLPNTIKQQY-QQQ LDNNSNGSSNNGFDG--QFMKKLRIFDSSTANLNKAALLRKRLRTKSLPNTIKQQ--QQQ LDNNSNSSSNNGFDG--QFMKKLRIFDSSTANLNKAALLRRRLRTKSLPNTIKQQQQQQQ LDNNSNNSSNNGFDG--QFMKKLRIFDSSTANLNKAALLRKRLRTKSLPNTIKQQYQQQQ ------------------------------------------------------------ LDESHDSS------------KRLRIFDS-SSMNHSSRASSQSNSPREPEVAHNGFSR--- LEPQESGVI-----------KKLRIFDSNTTS------SNSRNNSRNNSPNLVGTSGFKR LNNNSNN-------------RKLRIHEKTNAN---------------------------- LDETPDSSMP----------KKLRIFDSVSNV-------------------SSNSRASRN LNDD-------------TDRNRLRMFESKKPN---------------------------- LNNNSNN-------------RKLRIHEKINAN---------------------------- LLQQ---------------TKKLRIIEQLVSS---------------------------- LNGN-------------GNNRKLRIHEKTIGK---------------------------- VNDELDLAPIK---------SKLRLVSDTSGP---------------------------- LNDDEKP-------------AKLRIYESTVAA---------------------------- LGAD-------------SGNSKLRIFDSTQKR---------------------------- LDECQAIN---------STAKKLRIFDSNASQRSNSSKSRPQPILGNNRIRSRLSSSNAF ------------------------------------------------------------ FKQTSQESTRAHASNNHQNVHIPNNNSNNTNQQQSPIDQSASIYIQNLEEFHITSAMEGL KPKPKLPTQSQSNGQQQQQQQQQQQQQQQQQTQGQVNEQSSAIYIQHLQEFHITDAKEGL QTTNSRNNSSSNPGSTNNNIPGNINTNNSQRSSMAPNDQSNGIYIQNLQEFHITNAMEGL MRKKSIRYNYNSNNKAKSSNNTRPNTNDEPSSIAGPDENTNGIYIQNLQEFHITNAKEGL QAVNSRNNSSSNSGSTTNNASSNTNTNNGQRSSMAPNDQTNGIYIQNLQEFHITNAMEGL QAMNSRNNSSSNSGSAANNSSSNT---NGQRSPMTQNDQSNGIYIQNLQEFHITNALEGL QTMNSRNNSSSNSGSATNNISSDTNNNNGQRNSLAPNDQSNGIYIQNLQEFHITNAMEGL QTMNSRNNSSSNSGSATNNASSTTNTNNGQRSSMAPNDQSNGIYIQNLQEFHITNAMEGL ------------------------------------------------------------ RRQRPPPVKANRMS----------------ATKQQLSESGSGIYVQNVQEFHIINAREGI IFKTPVPYKQQQQHQQHLQQQQQQQPRLINNKQQSLSEQSSAIYIQNLQEFHITNAKDGI --------------------------------------KVKSIGIQNLTEYTINNYNQGI NSPKPNEGSSFGTRRKTRAPSIHRPTKSPVSKPVSPCEPSSAIHIQNLQEFHIMDAKEGI ---------------------------------------SDTLIIQNLQETYINSAIDGL --------------------------------------KVKSIGIQNLTEYTINNYNQGI -----------------------------ATKQTGNPSNRKKVFVQNLTESCVNNYQEAI ---------------------------------------SKSIGIQNLTEFCISDYNQGI -------------------------------------GPSSSTIIHNLSQIHIDSSEMGF -----------------------------NGNKKEAGKASKTISIQNLREESILSCQDGF -----------------------------------VVGPSSGIVVQNLIEQVVTSARQAV LKPSSSNLNTSNDTIASSSSSSSSSTSSAYTSSTVSPDKQTGIYIQNLKEFHITSAKEGI ------------------------------------------------------------ QLLQKGLKQRQVASTKMNDFSSRSHSIFTITLYKE--------QN-GELFRVSKMNLVDL RLLQKGLSHRQVASTKMNDVSSRSHTIFTLTLYKN--------FN-GETFRVSKINLVDL NLLQRGLKHRQVASTKMNDFSSRSHTIFTITLYKK--------HQ-DELFRISKMNLVDL SLLQKGLKHRQVASTKMNDFSSRSHTIFTITLYKE--------HK-DNLFRLSKMNLVDL NLLQKGLKHRQVASTKMNDFSSRSHTIFTITLYKK--------HQ-DELFRISKMNLVDL NLLQRGLKHRQVASTKMNDFSSRSHTIFTITLYKK--------HQ-DELFRISKMNLVDL KLLQKGLKHRQVASTKMNDFSSRSHTIFTITLYKK--------HQ-DELFRISKMNLVDL NLLQRGLKHRQVASTKMNDFSSRSHTIFTITLYKK--------HQ-DELFRISKMNLVDL ------------------------------------------------------------ NVLQKGLKHRQVASTKMNDFSSRSHTIFTIMLYKN--------CD-GELFRVSKMNLVDL NLLQRGLKHRQVASTKMNDFSSRSHTIFTIMLYKN--------HN-GEVFRVSKMNLVDL KYLKMGLQKKKTSSTNLNETSSRSHTIFSVQLYQKSSSSSSSENDEESVYRISKMNLVDL RLLQRGLRHRQVASTKMNDVSSRSHTIFTIMLYKK--------CN-GESFRVSKMNLVDL NILRKGLIKRKTASTKLNDVSSRSHTIFTVNLYKK--------QG-NEFFKVSKMNLVDL KYLKMGLQKKKTSSTNLNETSSRSHTIFSVQLYQKSLTPSGNDNE-ESVYRISKMNLVDL QAYKMAQARRKTSATNMNDKSSRSHAIFGIQLYKK------DPRN-DVVYKVSKMNLVDL KYLKMGLQKKKTSSTNLNDSSSRSHTIFSVQLFQK-----IPSDD-DSLYRISKMNLVDL NILKKCLTKRRTGSTRVNDLSSRSHAIFTINLYRE----VKNAAG-SSEYRISKMNLVDL QILQKGLLKRKTASTKLNDVSSRSHTLFTINLYRN--QPGSDGTG-SQLFKVSKMNLVDL DLLEKGHKKRTTASTRMNDVSSRSHSIFTIYLYRM-----DVEKN--EMVRISKMNLVDL ELLQRGLQYRQVASTKMNDFSSRSHTIFTINLYKE--------HD-GKIFRISKMNLVDL ------------------------------------------------------------ AGSENISRSGAMNQRAKEAGSINQSLLTLGRVINSLAD---------KSE---HIPFRES AGSENISRSGAQNQRAKEAGSINQSLLTLGRVINSLAD---------KNA---HIPFRES AGSENINRSGALNQRAKEAGSINQSLLTLGRVINALAD---------KSG---HIPFRES AGSENINRSGAMNQRAKETGSINQSLLTLGRVINSLAD---------KSP---HVPFRES AGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVD---------KSG---HIPFRES AGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVD---------RSG---HIPFRES AGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVD---------KSG---HIPFRES AGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVD---------KSG---HIPFRES ------------------------------------------------------------ AGSENISRSGAQNQRAKEAGSINQSLLTLGRVINSLAD---------KSI---HIPFRES AGSENISRSGAQNQRAKEAGSINQSLLTLGRVINSLAD---------KNA---HIPFRES AGSENISRSGS---IVKEAGGINQSLLTLGRVINSLNE--------KKLS---HIPYRES AGSENISRSGAQNQRAKEAGSINQSLLTLGRVINSLAD---------KSL---HIPFRES AGSENINRSGAVNQRAKEAGLINQSLLTLGRVINSLSD---RSLSASNTS---HIPYRES AGSENISRSGS---IVKEAGGINQSLLTLGRVINSLNE--------KKLL---HIPYRES AGSENISRSGS---MVKEAGGINQSLLTLGRVINALND----SSGKRSSQ---HIPFRDS AGSENISRSGS---IVKEAGGINQSLLTLGRVINSLNE--------KKLS---HIPYRES AGSEDINKSGAINERAREAGSINQSLLTLGKVINSLSE-------GKEQK---HIPYRES AGSENIYRSGAQNQRAKEAGSINQSLLTLGRVINSLSE-LANSSNADNTF---HIPYRES AGSENIHKSGAVNQRAKEAGSINQSLLTLGRVINCLSD---------KSGPLSHIPYRES AGSENISRSGAQNQRAKEAGSINQSLLTLGRVINSLAD---------KNI---HIPFRES ------------------------------------------------------------ KLTRLLQDSLGGNTKTALIATISPAKMTSEETCSTLEYASKAKNIKNKPQLG-AFI---M KLTRLLQDSLGGNTKTALIATISPAKINSEETSSTLEYATKAKNIKNKPQLG-SFM---M KLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLG-AFI---M KLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLG-SVI---L KLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLG-SFI---M KLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLG-AFM---M KLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLG-AFI---M KLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLG-AFI---M ------------------------------------------------------------ KLTRLLQDSLGGNTKTALIATISPAKINADETSSTLEYAAKAKNIKNRPQLG-ALM---M KLTRLLQDSLGGNTKTALIATISPAKINAEETSSTLEYATKAKNIKNKPQLG-TLV---M KLTHILQDSLGGNTKTTLIATISPAQVNLSETCSTLDYASKAKNIKNAPMIG-HDSEIIM KLTRLLQDSLGGNTKTALIATISPAKINSEETSSTLEYATKAKNIKNKPQVG-SFI---M KLTRLLQDSIGGQTKTALIATISPAKINLEETVSTLEYASRAKNIQNKPQLG-QDCDLML KLTHILQDSLGGNTKTTLIATISPAQVNLLETCSTLDYASKAKNIKNAPMIG-HDSEIIM KLTHILQESLGGNTKTTLIATISPAHINSMETCSTLDYAAKAKNIKNTPQNG-HDSDTVL KLTHILQDSLGGNTKTTLIATISPAQVNFSETCSTLDYASKAKNVKNTPRVG-HDSEVIL KLTRLLQGSIGGKTKTALIATISPAKINVHETISTLNYASKAKNIRNLPQSS-FD----S KLTRLLQDSIGGCTKTSLIATISPAKINIDETISTLDYACKAKNIKNLPQSG-HDSDLIM KLTRLLQDSLGGNTKTTLITTISPARIDLDETTSTLEYASKAKSIQNKPQSG-DSIDYLA KLTRLLQDSLGGNTKTALIATISPAKLNSEETCSTLEYAAKAKSIKNKPQLG-SII---T ------------------------------------------------------------ KDILVRSITSELAKIKSDL-----LSTKSK------------EGVYMSHEH---YKDLHY KDILVKNISHELAKLKSDF-----LSTKSK------------EGIYMSHLH---YNEVMN KDILVKNITMELAKIKSDL-----LSTKSK------------EGIYMSQDH---YKNLNS KDILLKNITSELAKVKSDL-----MSTKSK------------DGIYMSHEH---YQELIM KDILVKNITMELAKIKSDL-----LSTKSK------------EGIYMSQDH---YKNLNS KDILVKNITMELAKIKSDL-----LSTKSK------------EGIYMSQDH---YKNLNS KDILVKNITMELAKIKSDL-----LSTKSK------------EGIYMNQDH---YKNLNS KDILVKNITMELAKIKSDL-----LSTKSK------------EGIYMSQDH---YKNLNG ------------------------------------------------------------ KDILVKNISSELAKIKSDF-----LSTKSK------------DGIYMSHEH---YQEIVN KDILVKNITRELAKIKSDF-----LSTKSK------------DGIYMTQDH---YKELTS KKTLVKNLAQELTLLNMDL-----IATRNK------------NGVYLDPEN---YDQLIQ KDVLLKSVTAELVKIKSDL-----LSTKSK------------DGIYMSQEN---YKELTN KKILLKDMSKEITKLNKDL-----IATRNK------------NGIWMDENN---YNTLIE KKTLVKNLAQELTLLNMDL-----IATRNK------------NGVYLDPEN---YDQLIQ KRTLLKNMSIEISQLNLEL-----EATRNK------------NGIFLEKNR---YYDLHQ KKTLVKNLAQELTQMNMDL-----IATRNK------------NGIYLDAEN---YDKLIQ EMILKKVLVSDLSGPN------------------------------LSHDQ--------- KRVLVKNLSQEIAKLNFDL-----IATRNK------------NGIWLNEDN---YNAIME KKILIRDMSNTLRKLQDDL-----IATRKK------------NGIWMDETT---YNEFVN KDILVKNIASELAKVKADL-----LSTKSR------------DGVYMSQIH---YKELTN ------------------------------------------------------------ DIECYKTELEE--------SKRAIESL---------------TAQNAMLQQERLSLKDDN DIENYKTEIQE--------SRREIEKL---------------SSQNQLLHKDKKSSQDTI DLESYKNEVQE--------CKRDIESL---------------SSKNSLLLKDKLKSKDTI ELESSKTEVQE--------SKRMIEKL---------------SSQNSMLLKDKRSANEVN DLESYKNEVQE--------CKREIESL---------------TSKNALLVKDKLKSKETI DLESHKNEVQE--------CKREIESL---------------ASKNSLLVKDKLKSRETI DLESYKNEVQE--------CKREIESL---------------TSKNSLLVKEKLKSKETI DLESYKNEVQE--------CKREIEGL---------------ASKNSLLVKDKLKSKQTI ------------------------------------------------------------ DLENCQTEIQE--------SKRQIESL---------------TSQNNLLLKDKKASQEVT DLENYKTEVQE--------CKREIEKM---------------NSQNVLLLKDKRASHEVS ENESLKTGAKE--------DRLKLESL--------QAKIETLEFTKLEAKEEIDNLKQQL ELENYKTEVEE--------CKRAMEKV---------------SAQNSLLIKEKRVSNEVN NNDLIKAELKE--------SNSIINGL--------NMKISQLSNLKKTTELNNKNYKSKI ENESLKTGAKE--------DRLKLELL--------QAKIETLEYTKLENKEEINNMKQQL ELDSLRNQLRE--------KDLAIELL--------TSKCNNLTQLNLEKTSEVKLIMTEV ENNALKTQERE--------DKLKIESL--------KAKVATLEFTKLENKEEIDSLKQEI ------------------------------------------------------------ ENESLKASLKE--------SNLQNELL--------NSKISQFEVFKANNENNIKKLREQI ETESLKTQLRE--------SKALITGL-------------------NLKLEKTKQENTAL DLESYKTEVQE--------CKRVIDGL---------------TTQNGLLLKDKKASNEVH ------------------------------------------------------------ ACYK-ANIASL-KDNVVTLQSSLKEQITKET----------------------------- ESQR-LQIRNL-QSSMDYLYEK----IDLKH----------------------------- QSQN-SQMESL-KLTINQLKAQ----LDKQH----------------------------- ELQR-IKLNNL-KDSMSNLNEK----LEIQN----------------------------- QSQN-CQIESL-KTTIDHLRAQ----LDKQH----------------------------- QSQN-SQMESL-KATINHLKAQ----LDKQH----------------------------- QSQN-SQIESL-KATIDHLRTQ----LDKQH----------------------------- QSQN-SQIESL-KATIDHLRSQ----LEKQH----------------------------- ------------------------------------------------------------ ELQN-SKIKKL-QSTIEYLYDK----IERQH----------------------------- ELQR-IKIKHL-NDKIAHLYDK----MDKQH----------------------------- QSYQ-SKLQIL-ETKYHK------------------------------------------ ESQK-VKLRKL-GNNIEFLYDK----IDRQH----------------------------- NEYQ-LKIKSL------------------------------------------------- QSYQ-LKLQILETKYHKAVGLN-------------------------------------- ENQ---------KKELSQLQNSNDALVELNK----------------------------- SGYK-TKLNTIEKKYRQAVNTNND------------------------------------ ------------------------------------------------------------ NKQ--VGINEELSNESTLLKSY-------------------------------------- ETKA-LDNEREKHEMGSLVRES----QSKQR----------------------------- NLQK-IKLQSM-KDSISHLHDS----IEKQH----------------------------- ------------------------------------------------------------ ------------------------NIRSLLKDVQGANEEMKKTIH--LFEFKQQELQQSI -------------KNEIELTNMIMKLKDAVRNMQGALKTHEDHEQ--RLQSDIQKMYDNI -------------KTELE-------------------------IS--GFNNKLQKLTEIM -------------GNETKLMEQIGQLEKSREKLNSLVKNYQTKQS--QLKTQISNILNEN -------------KTEIE-------------------------IS--DFNNKLQKLTEVM -------------KAELE-------------------------IS--GFNNKLQKMTEVM -------------KTELE-------------------------IS--GFNSKLQKLTEVM -------------KTEIE-------------------------IS--GFNNKLQKLTEVM ------------------------------------------------------------ -------------HNETELATTIHKLKEALHTMQGSLKSYETHEL--RLQNDIKEVYQGI -------------KNEQDLVCTIHTLKDAIYTVQNSLKNCEDYQL--QCKSEMEDVLYD- -------------AVGLN-QTNQETICELNNKLKQAFEKSSSSAE--LLVNLLSNHLHTS -------------KNEQELSNVVQELMRALHTMQQSLRIYEDQGQ--RFHTEMERVYDNI --------------ENIE-TNNKKQISDNDTMISTLNDKLFKLNE--NYKSSKLQLTQLI --------------------------QTNQETIYELNNKLKRAFE--KSSSSAELLVNLL -------------KQKEDLAHYQSLLHTIKNQYYELSHLQMSNFI--KYVKKSRSV---F ---------------------NQATISALNEKLKRAFEKSSSSAN--MLVNLLSNHLKSS -----------------------------------------------RFDGKQRQG---- -------------------------IVSKDEEIKQLSEQLVKANE--KFSSTTNQLVKVI -------------DLEADVASRSATIMSMSQKMSELENNYTRASN--FLKTTVSEKINEA -------------RKEQTLVDLILKLKSKSIEMQATIKYHSEREQ--VTQAKMKQIFNEE ------------------------------------------------------------ STFISDE----------------------------------------------------- LEYRRKI----------------------------------------------------- QLALQDY----KRRELD------------------------------------------- LFELKKI----------------------------------------------------- QMALHDY----KKRELD------------------------------------------- QVALQDY----KKRELD------------------------------------------- QMALQDY----KRRELD------------------------------------------- QVALHDY----KRRELD------------------------------------------- ------------------------------------------------------------ TSYRESM----------------------------------------------------- ------------------------------------------------------------ IGLVNES----------------------------------------------------- GSFKKSL----MDEIEK------------------------------------------- NNSLNDS----------------------------------------------------- SNHLHTS----------------------------------------------------- KKYFPAY----------------------------------------------------- IGYLGDI----------------------------------------------------- ------------------------------------------------------------ YRNLDTS----------------------------------------------------- LTTIAGI----------------------------------------------------- LLRLKSL----------------------------------------------------- ------------------------------------------------------------ ----ISNIRDT-LKKHIEYLQNNGD-------------------LKDTEISGNLMRLEKE -----ETKLDN-LKQQALEQSFTID-------------------DDINNVKDSLETLLET ---LNKKFETH-ISKEIKSLKTTLF--------SQLSGMEQNNISQETNIQPNLDIIKNE ----LNSHKDA-IRQSEGNFDVEMN---------------------LKVIKDEITSMLEK ---LNQKFEMH-ITKEIKKLKSTLF--------LQLNTMQQESILQETNIQPNLDMIKNE ---LNKKFETH-ISKEIKSLKTALF--------LQLDNMQQKNIFQETDIQPNLDMVKNE ---LNKKFETH-ITTEIKNMKTTLF--------SQLSTLQQRNILQETDIQPNLDIIKNE ---LNKKFETH-ITKEIKNLKSTLF--------LQLNTMQQENILQETNIQPNLDIIKNE ------------------------------------------------------------ -----NQHLEK-VKVSMLDKNLSIK-------------------ENINNITTIFDDTLKS ---HVTSFKQS-IHEQLAAMKASHS-------------------SRHLGIDGNIDIIQEE ---RNLQQDNK-SVDQLTNFQLEFT-------------------KNLDEYKQQLETNLQN ------------LKINVDENGDDVE-------------------VNVDAVTTELTRIFDF -ISQIENVVTD-LNNSKESQNNSLN-------------------ASIKSIQNNLQTCKNS -IGLVNDSRNLQQDNKSVDQLNNFQ----------------------LEFIKNLDEYKQQ ---------ST-TSGVEEEVESDIE-------------------RLKKKLYENFNALANF ---KKLQTDND-SVDELTNFESELG-------------------KQLHDYQTQIDVQVKE ------------------------------------------------------------ -INSIQDILSQYNNSANGETLFTFN-------------------TQLTGNIENFRKSLEE -------SSEL-SNSNDVKYLQQVQ-------------------NKVAASLNGFKISLYQ ----LIENLER-INKKIVINNTDLG-------------------MNIEKIKDEVKSIIDT ------------------------------------------------------------ VVKV-----IKAAE---EE-------ASKSYGECVK------------------------ VKKD----------------------AIIMCENLAQ------------------------ VLTL-----ME-TM---QEK------AELMYKDCVK------------------------ TQHK----------------------TEMMYKEFIE------------------------ VLTL-----MR-TM---QEK------AELMYKDCVK------------------------ VLTL-----ME-TM---QEK------AELMYKDCVK------------------------ VLTL-----ME-TM---QEK------AELMYKDCVK------------------------ VLTL-----MK-TM---QEK------AELMYKDCVK------------------------ ------------------------------------------------------------ VEAN----------------------GSDMCDTLVK------------------------ LSQV-----LE-SI---CST------SVDVCRSCVE------------------------ YQSQ-----VGN------------------------------------------------ MNSS----------------------NIEVFRNYIK------------------------ LSET----------------------IASTNTELS------------------------- LGKN----------------------LQDYQLQVGN------------------------ DEKN----------------------FRITYNDVPVAEFIN------------------- YQKN----------------------VGE------------------------------- ------------------------------------------------------------ KIAE----------------------INDNLAN--------------------------- VSEK----------------------LNSQFE---------------------------- TQAE----------------------ANHVYKDCME------------------------ ------------------------------------------------------------ ------MMLKETPRLFES----------------------VSGRLDNISKLAEENHSKIA ------KVVGDQPKFFNS----------------------MLSELNDMFSKVDEHTDRLK ------KILNESPKFFNV----------------------IVEKIDIIRVDFQRFYNNIA ------EFLEQTPINLQK----------------------IFEHVTQVEFMVTGYYNEIT ------KILNESPKFFNV----------------------VIEKIDIIRVDFQKFYKNIA ------KILNESPKFFNV----------------------IVEKIDIIRIEFQNFYKNIA ------KILNESPKFFNA----------------------IVEKIDIIGVDFERFYKNIA ------KILNESPKFFNV----------------------IVEKIDIIRVDFQKFYKNIA ------------------------------------------------------------ ------LIKETPSMYLKE----------------------FNETVSSLKSELSSYSNALT ------KILESNPKHFES----------------------IRRDLLDISTVVDSYSNELV ------IVNEDLTNYIST----------------------FQKNFDNLLTFQQEFYNKTF ------KVNDQTPAYFKD----------------------IYSQVESITSVVSSYSSNLM ------QSIDKIPKMMSD----------------------INSNFHDFNGIVSDNESKIK ------IVNEDLTNYIST----------------------FQQNFDNLLSFQQEFYTKTF ------RCIEMQDTILSK----------------------VQHKMRAMENTGNEVLNQLR ------VMNQDLTNYITT----------------------FKQNFDNLLTFQQDFYTRTQ ------------------------------------------------------------ ------SLLQDLPYFLEK----------------------YNENYDKLSTLISSLNSQLM ------HALKVLPGVLEP----------------------LGEQVSQQHTLREACERKVE ------QLMKESPILLGS----------------------LNDDIIKMQKISDLYNEQLS ------------------------------------------------------------ ETLSDVSEEYNNLKQYLTNNFFK------------------------------------- EGLSQITAENNNLKAYLDTHFFR------------------------------------- ENLSDISEENNNLKQYLKNHFFK------------------------------------- ENLSDISEEYNNLKQYLDNDFF-------------------------------------- ENLSDISEENNNMKQYLKNHFFK------------------------------------- ENLSDISEENNNLKQYLKNHFFK------------------------------------- ENLSDISEENNNLKQYFTNHFFR------------------------------------- ENLSDISEENNNLKQYLKNHFFK------------------------------------- ------------------------------------------------------------ NKLTEISEENNHLREYLDQHLFK------------------------------------- KNLGDISEEYNNFREYLNEHLFK------------------------------------- EVIQDFKIINEKLSGFLKDDYLHNI----------------------------------- IHLSSISEEYNNLKDYLNEHFFK------------------------------------- ASMSDLKIANDKFSGYITEEHLD------------------------------------- EVIQDFKIINEKLSGFLKDDYLHNI----------------------------------- NHVDLDRSELIRKKRSNVLLRN-------------------------------------- EVIQDFGIVNEKLSGFLKDDYLANL----------------------------------- ------------------------------------------------------------ QNLSDLKVANDKLSGYIIEDHL-------------------------------------- HQIDEVRSSNSNFEKYVTEEHLK------------------------------------- ISISELNIEHNDLKQYLNGSFFK------------------------------------- ------------------------------------------------------------ ----------------------------------------------NNHEELLSHHVQNT ----------------------------------------------NNHQEILNVHADKT ----------------------------------------------NNHQELLNHHIDST ---------------------------------------------QNNHEDLLNIHINAT ----------------------------------------------NNHQELLNRHVDST ----------------------------------------------NNHQELLNHHIDST ----------------------------------------------NNHQELLSHHVDST ----------------------------------------------NNHQELLNRHVDST ------------------------------------------------------------ ----------------------------------------------NSTQEVLDLRMESV ----------------------------------------------NNHEETLSIHVDKT ---------------------------------------------ETNLNSQLGNILGEN ----------------------------------------------NNFQEALDVHVDRT ---------------------------------------------SQALNNVINQIVSER ---------------------------------------------ETNLNSKLATILGEN ---------------------------------------------FAGLKDLLKLSIDRQ ---------------------------------------------GTTLNSRLGSLLVNN ------------------------------------------------------------ ---------------------------------------------NYNAQELISQLIETK ----------------------------------------------AIETALSDSIKERI ----------------------------------------------SDHEEILNEHIEKT ------------------------------------------------------------ YAQL---EENSAQLMQN-----------FTMMLDKHIQENK--RHMLENILGVTDEVINN YHQL---NLSSKHLMSK-----------ITNIISDHVEQNR--TLLMDTLKTATTEVITQ YEDI---EKKTSEFVEN-----------FKNTLNDHLEENK--KLIMQNLTNATSAVINQ SDIL---AQSSAELFNK-----------FKIMMDAHLMENK--KLMIDNFRTATNDVITK YENI---EKRTNEFVEN-----------FKKVLNDHLDENK--KLIMQNLTTATSAVIDQ YENI---EKKTNQFVEN-----------FKMTLNDHLEENK--KLIMQNMTNATSAVIDQ YEKI---EKKTNQFVEN-----------FKKALNDHLEENK--KLIMKNLTTTTSAVIDQ YENI---EKRTNEFVEN-----------FKKTLNDHLDENK--KLIMQNLTTATSAVIDQ ------------------------------------------------------------ YQKV---KNDSDQLLSK-----------LVSMVGAHVEESR--TLMVNSMKDTVNEIIDN YHML---KKSAGELFSK-----------FKEMMDSHLEENK--SLMIKSLKTASDEVVAK LPIL---VDNFKKIMTK----------ELKTTMNNVMDKYKTVSN--EEISKERENVLKM YHQL---KVSANSIFLK-----------LREMLNEELDTNK--EFMMQSLRHAASEVVAK VNEQ--LSSIKSNMLNK-----------FSKLLDDTHLKHE--SLFKDSVNEVSSKFINL LPIV---VDNLKKLMTK----------ELELTMNNVITKYKTVSN--EEISKERENVLKM VEEQ------------------------LKKMTCQTDLLHK------EDLDLQQQVLENF FSPL---VENFKNLMMNEIEGT------IDTVMKDYREISN------EEISKERANALKM -----------------------------------------------EWYQDECPELRGT VSSQ--LTKLHEKMDKS-----------IATILRDSKQNYK--KLFETSISQISQELIES TNNL---SAMQNTITTE-----------IATMLNKTFTQQQ------GELPRLLTEDTVS YDNI---RRASTGIVEQ-----------LKTGLELYLEESR--NIIIDSLKNTTSDIVKS ------------------------------------------------------------ E-----------------LQMFGEQRAKWEKSSALINQ-----CDSV------------- E-----------------MSHFEPVRKTWEQSFNHINV-----CDSL------------- E-----------------MDLFEPKRVKWENSFDLINK-----CDSM------------- E-----------------MELFKPKRNKWEESIELINR-----CDSI------------- E-----------------MDLFEPKRVKWENSFDLIND-----CDSM------------- E-----------------MDLFEPRRAKWENSFDLINK-----CDSM------------- E-----------------MSLFEPKRVKWEHSFDLINE-----CDSM------------- E-----------------MDLFEPKRVKWENSFDLIND-----CDSM------------- ------------------------------------------------------------ E-----------------RSLFQPIRDRWIASCDNINQ-----CDAS------------- E-----------------VKLFAPVKQKWESSLENINK-----CDSL------------- E-----------------NSWNSQINCLLPKLETDLNN---------------------- E-----------------MCLLDPVKQAWENSLENINE-----CDKL------------- E---------------------------RNTLLERQSN-----WFHE------------- E-----------------NSWNSQINNLLPKLETDLNN---------------------- E----------------------------------------------------------- E---------------------NTWNDQIKTILPKLEK---------------------- Q----------------------------------------------------------- E-----------------RNEISKREKNWSTETSRVLN---------------------- K-----------------------VQAEKQELQKQATS---------------------- E-----------------MELFAPKKKKWEDSFEMINK---------------------- ------------------------------------------------------------ ------------NHSFHQALGSNL-----------VEIRDV------------------- ------------SNKFKDDTTESL------------------------------------ ------------NNEFYNNMATTL-SQIK------NTVDTS------------------- ------------NNGFHHNMTGQVSKIKTNLASSSSSIHNA------------------- ------------NNEFYNSMAATL-SQIK------STVDTS------------------- ------------NNEFYNNMAATL-SQIK------KTVDTS------------------- ------------NNEFYNSMATTL-SQIK------STVDTS------------------- ------------NNEFYNSMASTL-SQIK------STVDTS------------------- ------------------------------------------------------------ ------------HQNFEAKSTSGL-DKLK------------------------------- ------------NNTFDSTVKDAL-RRLE------GNIEGS-------------LEFSKN ------------NNKFHHDCQTNLQKFIN------------------------------- ------------NNVFENKIGVTVNEIFK------------------------------- ------------SEKFYNSIDKDA-----------TSFKKQ-------------YHDFND ------------NNKFHQNCQENLQNIIN------------------------------- ----------------KKWKQGSLGSALNESEINKSTTGAS------------------- ------------ELESNTRIHQDCKTKLQ------------------------------- ------------------------------------------------------------ ------------VIDLQMYEARQE------------------------------------ ------------------WLARSSHLHISVVDELQSYGKSS------------------- ------------CDSLNNKYFGDISALLS------------------------------- ------------------------------------------------------------ ------------VSSSRDNIGATISSIQSRTRNRQSIE---------------------E ----------------NSLKSHMESTVRESSLIADKIK---------------------- ------------SNSMNKSISVMKGQVEESENAVSLLK---------------------N --------------IASIKSQVLEQLSNDDSDVKTALE---------------------N ------------SNSMNESISVMKGQVEESENAISLLK---------------------N ------------SNSMNESISVMKGQVEESENAISLLK---------------------N ------------SNSMNKSISVMKGQVEESENAISLLK---------------------N ------------SNSMNESISVMKGQVEESENAISLLK---------------------N ------------------------------------------------------------ ---------------ELSDASLKSSEDAVNKAKHRTDS---------------------- TAGD--------VKDSLKKFDGISEVLKNNTKVVNNIN---------------------E ------------NNDICERINKFQQDNNSQLDKINPFD---------------------L ----------------TIDQGQKTSQVTTEDAKSELTR---------------------- ENSH---------KLSTTTNNISSLITNTINPNLAKIN---------------------Q ------------------SNDICDKINKFQQDNSQLDI---------------------- -----------------ETLQFRNQNQTQYQEQCRDRD---------------------- --------------SISTSDEIFKRMNQLKDHKIKLSN---------------------- ------------------------------------------------------------ --------------EVEQSKAIFDSLSMLTTERLTDLK----------------NKTTEN ----------------KESLELMEHSIDSASKTIGETI-------------------HQK --------------NMKTSVTSTSDLVDDHVSQMRKYT---------------------- ------------------------------------------------------------ MIQ-GNDVIRQQITRIKQKNKSLSLFKEHSTETA-------------TTSIGSVNKVEGN ----DNLCHFQDRNDIANM--TTNINGTVDDIK--------------NKHSVLRDELEKN NKK-FNDQFKQLVNKHTIL--KDNIENSITSTH---------------SHITNIDDIYDT DPM-FNKHFNEIIEKNMIL--QKNRKNAINYTDKSL-----------LNIDELSETVKIA NTK-FNDQFEQLINKHNML--KDNIKNSITSTH---------------SHITNVDDIYNT NTK-FNDQFKQLISKHIIL--KDNIESSITSTH---------------SHITNVDDIYNT NIK-FNDQFKQLINKHTIL--KDNIESSITST---------------NSHITNIDDIYNT NTK-FNDQFKHLINKHNIL--KDNIENSITSTH---------------SHITNVDDIYNT ------------------------------------------------------------ ----FHDFVQKLCCDQSLKKQMHDIS---------------------DKHRMLEDHFDDN VKE-KHTFLRDQVERTSSY--IEAANEKFEGID--------------QFIRQIIDKK--- KPK-LTSSINGITNDIQQY--HNQMNNNLTKIN--------------QELTQIQQFDANT ----VRAAFSSLQNNGIILQNVDSIKKKHNLLK--------------SQVQDSANYMQAA IID-KNNLLDDMPKLKSISDLIIKKDDRVCESL--------------NHVNQNLNSLQYD ----LNDFDLKPKLTSSINVISNDIQKYQDQMN--------------NNLNKINEELTQI ----RDIDYGQDISKSTRTDRNHHHQHRMQQSP----------------INTRRRTMSIS ----HPNFSKLSKITTNIKQNNEMIETNLDKID--------------KELNEIQQFDANT ------------------------------------------------------------ LSK-LTELVNEENPKVSLLQRNLPCLEDISKNI--------------QLNDIKIRDSLTT LNP-QLELLKDSINKENTASTIEELESAFGRIN--------------SKSKQVQKGLVDT ----DNTSRSTKLTENSKR-----IGQQFTEMM--------------EKNSKLESHLNES ------------------------------------------------------------ LKVIMDKVLNDPQLSRGKAEV-------------PDEELHRLEKIPLG-------ITNKE VSFIHASSEGFKAIDSSLKRIMNFRMPEGKT---ETLADDLIKHIDSS-----VAPVASS IENIMKNYGNKENAVK------------------NEMIDNILKEIPSLSKRVPLRLSNTN LNNIVDDVAITDGDDNSPGTK-------------TKSKLRPLRSASQL-----LINSNQN IENIMKNYGNKENATK------------------DEMIENILKEIPNLSKKMPLRLSNIN IEDIMTNHGNKENATK------------------DEMIDNILKEIPNLSKRLPLRISNIN IEKIMNNYGNKENATK------------------DEMIENLLNEIPNLSKRMPLRISNTN IENIIKNYGNKENATK------------------DEMIDNILKEIPNLSKRMPLRLSNTN ------------------------------------------------------------ VKYFKESSKGFEDMDCSIKKIIHEMSPEVGD---IKSVETLMERINAR-----FSPVRPT ---LPTHLVGNGELVNVML---------------EQLGKTHLKPIGSA-----SRTPSSR MKI-----SPIKESSRIPITT-------------ANMPNNQFKPIKLHRSNTTCGGGGAT TQKFGEIDNSIQDLLNAQTIP-------------QPQSENPIDGLLEQLNDKSLKPLGPS ITSNEANVIMKSPVRSPNKSPIKHTKPSP-----FKQLNSPTKESSSS-----PSKRLPS QQFNTMKISPIKECSRIPITS-------------MNITNNQFKPIKLH------RSNTTC PQK------------------------------------SKIPTMKRL-----ASTLLDD VKI-----SPIKDTSN------------------ISQFNKPSLSPSRA-----VRVHRSA ------------------------------------------------------------ IDKSLQDIKQFDAKQAFKLSPVRGSKQIE-----IDGLKRSPSRSPSY--------SNPP TT-TLHSIQEFEINLPSTSTAERVLQEV------SPNRARHTLSSGSA-----VKRPAET ITMNESSINAFDKLSESIHSAFEKY---------NTANTISRLDESTN-----LMKQNKD ------------------------------------------------------------ NVVDLQHRYP-------------------------------------------------- GKTPLRPLLK-------------------------------------------------- GNSAQNILSPKKHA---------------------------------------------- KENGVRGIDV-------------------------------------------------- SNSVQSVISPKKHA---------------------------------------------- GCSVQDIISPKKHT---------------------------------------------- SNSMQNIISPKKHA---------------------------------------------- GNSVQSIMSPKKHA---------------------------------------------- ------------------------------------------------------------ GKTPSRQVLK-------------------------------------------------- SVSPMKTLDNNIFN---------------------------------------------- GKSPSPTRIP-------------------------------------------------- GKTPMRTVQR-------------------------------------------------- AKSSPSKKSP-------------------------------------------------- GDSNEKSLSP-------------------------------------------------- QTKRQKVPSS-------------------------------------------------- GTSPTRIPSL-------------------------------------------------- ------------------------------------------------------------ SRTASRQISP-------------------------------------------------- SLQPLSKIPS-------------------------------------------------- GDISLDRVEM-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SETKQR ------------------------------------------------------------ -----------------------------------------------------TESKLGN ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------IEDGNKSSEN ------------------------------------------------------------ ------------------------------------------------------NAITSK ---------------------------------------------------------GIS ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------LKRQ ------------------------------------------------------TRIPTL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SLSKSVSPAKSS------------------------------------------------ ------------------------------------------------------------ SNSQILKI---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ADSEGSRKMLKTE----------------------------------------------- ------------------------------------------------------------ ASSRSMSPIKTLDTN--------------------------------------------- PSKRKVDETENDRSKSQRIK---------------------------------------- ------------------------------------------------------------ ----SVTNTDQLLPPQKSSYTISP------------------------------------ SSSIALSVNTD------------------------------------------------- QRSKTITNSEDILHD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LPLSPIFFSENKNNHVLSPSKVVVNSS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ALQEKRKPEDEVLLQAKLQRRNPD------------------------------- -----HATIINSPLKRKSSDSRIFPGNSK-KQR--------------------------- -----IDDENPSNEITDGEESRKIQKTE-------------------------------- -----RSKRKQLDENDGNLASKKISRLNR------------------------------- -----IEDENKSSENVDNEGSRKMLKIE-------------------------------- -----IEDENPSSENADSEGSRKIPKTE-------------------------------- -----IEDENSSNGNPDSESSRKILKTE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----VRIISPVKRGTIEFGAEGPPTKKV------------------------------- ------------------------------------------------------------ ----------TLQRSKSNVPEDTSPQDST-TTNNNKKRKILQTMDNLL------------ -----IKEIDGNRRLTSPHKRGVVSDHER---PAFKSQRIE------------------- -----LQRTKIPQLSRSNSDKENVSAAAF-KRRRIIHDVNTTLNK--------------- -----LDSGTPIATATATKKRKILQTMDN------------------------------- ------------------------------------------------------------ -----QRSKSETEYSSSAKRRKILHTLDN-VSN--------------------------- ------------------------------------------------------------ -----IKTAGTLARTKIPQLNRSLDNKENQGPSQKRRRVLQQVDNFLHG----------- -----LSRANSDNESVSKKRRTTTKLNMP------------------------------- -----AKKIQASKYQKRLNSTEDMDPIA--TKVQKIK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------YNRPRLIVLIRHGESESNKDKKINEVTPNHLIPLTPYGKKQAHNA ----------------MKPRLILLIRHGESESNKDKKVNEHTPNHLIPLTKNGRYQARMA ---------------NARPRLIVLVRHGESESNKNKEVNGYIPNHLISLTKTGQIQARQA ---------------GHKPRLIILIRHGESESNKDKKINEVVPNHLIPLTDNGWEQARNA ---------------NARPRLIVLIRHGESESNKNKEVNGYIPNHLISLTKTGQIQARQA ---------------NARPRLIVLIRHGESESNKNKEVNGYIPNHLISLTKTGQIQARQA ---------------NARPRLIVLIRHGESESNKNKEVNGYIPNHLISLTKTGQIQARQA ---------------NARPRLIVLIRHGESESNKNKEVNGYIPNHLISLTKTGQIQARQA ------------------------------------------------------------ ------------------------------------------------------------ ---------------PHKPRLILLIRHGESASNKDKSINQHTPNHLVPLTEAGWRQARHT ---------------MGKPKYILIVRHGESEGNCDKSVNRYTPNHLVQLTDNGHCQALQA ---------------HHKPRLIVLVRHGESVSNKDKSINQHMPNHLIPLTDNGYKQARRS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GEALSKFLLDQRLETAGNDDKA----------------------- ---------------------------MKSEDGKN------------------------- ------------------------------------------------------------ ---------------NTNLQYILLVRHGESEGNCDKSVNRFIANHKVVLTETGHKQAKNA ---------------SHKPRLIVLIRHGESESNKDKLVNEHTPNHLIPLTEHGWAQAKAA ---------------HILTQLIILIRHGESEGNCDKSVNRHTSNHRIKLTANGEEQARDA GLKLLRLLHMDDNIIFYTSPYKRTRETLKGVLEVIDRYNEPHD-LENSIRYRIIDEPRLR GIEILKLLTKDTDLVFYTSPYRRTRETLKGIIEMIDRYNEQCP-VFPSLHYRVKEEPRIR GIDLLRVLEKDMNVVFYTSPYRRARETLKGILDVIDEYNEPRGINNSGLQYRVKDEPRIR GVELLKVLTLDKNIVFYTSPYRRTRETLKGILDVFDEYNHPC---VPSLQYRVRDEPRIR GIDLLRVLEKDTNIVFYTSPYRRARETLKGILDVIDEYNEPRGLNNTGLQYRVKDEPRIR GIDLLRVLEKDTNVVFYTSPYRRARETLKGVLDVIDEYNEPRGINNTGLQYRVKDEPRIR GIDLLRVLEKDTNIVFYTSPYRRARETLKGILDVIDEYNEPRGLNNTGLQYRVKDEPRIR GIDLLRVLEKDTNIVFYTSPYRRARETLKGILDVIDEYNEPRGLNNTGLQYRVKDEPRIR ------------------------------------------------------------ ------------------------------------------------------------ GVELLKLLSKDSNIVFYTSPYRRTRETLKGVIDVLDEFNEQCP-IFPSLHYRVKEEPRIR GQVLSEFLRNPKSMMFITSPYLRTRQTCNNIIEGIKNVPG--------VEYKVREEPRMR GAELLQLLNKDSNIVFYTSPYRRTRETLRGMLDVLDEYNEQCP-EFPHIHYRVKDEPRIR -------------ILFYTSPYLRARQTCNNIIDGIKYVPG--------VMYKVHEEPRMR --------------MFLTSPYLRTRQTCNNIIEGIKNVSG--------VEYEVREEPRMR --------------MFYTSPYLRTRQTCNNIIEGIKDLPD--------VDYCVREETRMR --------RNPRSIMFFTSPYLRTRQTCNNIIEGIKNVPG--------VEYDVREDARMR ----------PRSVLFYTSPYARARQTCQGIIDGIEDLEG--------VEFRVSEEPRMR --------------MFYTSPYSRARQTCNNIIEGIKDLPG--------VDYTIREETRMR GIVLRSFLRSCKSISFYTSPYSRARQTCTDIINEIKDLPD--------VEYSVNEEPRMR GINLLNILKKDLNVVFYTSPYRRTRETLKGVLDVIDEYNERQ--KLPTICYRVKDDPRIR GKRLADMVNKDDTLLFYTSPYQRTRQTTQLICEGIEEKN---------ISYKVHEEPRLR EQDFGNYQEVSS-MQDVMEKRKTYGHFFFRFPEGESAADVYDRVASFQDTLYRHFQHTKG EQDFGNFQKTAS-MTEVMNTRANYGHFFFRFPQGESAADVYDRCSGFQESLFRHFEGGKK EQDFGNFQKINS-MQDVMKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRHFHERRP EQDFGNFQEVSS-MQDVMSKRATYGHFFFRFPEGESAADVYDRVASFQETLFRHFETRKA EQDFGNFQKINS-MQDVMKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRHFHERRP EQDFGNFQKINS-MQDVMKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRHFHERRP EQDFGNFQKINS-MQDVMKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRHFHERRP EQDFGNFQKINS-MQDVMKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRHFHERRP ------------------------------------------------------------ ------------------------------------------------------------ EQDFGNFQEVSA-MSHVMSTRSSYGHFFFRFPQGESAADVYDRCASFQETLFRHFESKKK EQDFGNFQPSSDEMELIWKERAQYGHFFYRIPHGESAADVYDRVASFMESLFRQFRSDDF EQDFGNFQELSS-MRDVMSTRANYGHFFFRFPQGESAADVYDRCSSFQEALFRHFHDRKP EQDFGNFQSTSEQMEKIWQERAHYGHFFYRIPHGESAADVYDRIASFNETLFRQFQQDNF EQDFGNFQPSLDEMELIWKERAQYGHFFYRIPHGESAADVYDRVASFMESLFRQFRNDDF EQDFGNFQKSAEEMEKIWEERAHYGHFFYRIPHGESAADVYDRVASLNESLYRQFRQDDF EQDFGNFQPESEEMERIWKERAQYGHFFFRIPHGESAADVYDRVASFNESLFRKFRYDTF EQDFGNFQSTAEEMERIWGQRAHYGHFFYRIPHGESAADVYDRIASFNETLFRQFSRDSF EQDFGNFQATPEEMERIWEERAHYGHFFYRIPHGESAADVYDRIASFNESLFRQFQQDDF EQDFGNFQSTPEEMEKVWEERAHYGHFFYRIPHGESAADVYDRAASFNESLFRQFRQKDF EQDFGNFQEVRS-MQDVMEKRQTYGHFFFRFPQGESAADVYDRVASFQETLFRYFEKRKP EQDFGNFQASASEMNKIWNDRSQYGHFFYRIPNGESAADVYDRCAGFNETLFRQFNSDKF RDVVVLVTHGIYSRVFLMKWFRWTFEEFESFTNVPNGSLMVMELDEKLNKYVLRTVLPKW RDVVAIVTHGIFLRVFLMKWFRWTYEEFESLTNVPNGSVIVMELDEKDDRYVLRTTLPKW RDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTNVPNGSVMVMELDESINRYVLKTVLPKW RDVIVLVTHGIYSRVFLMKWFRWTYEEFESFTNVPNGSMMVMELDESVDGYVLRTVLPKW RDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTNVPNGSVMVMELDESINRYVLRTVLPKW RDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTNVPNGSVMVMELDESINRYVLRTVLPKW RDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTNVPNGSVMVMELDESINRYVLRTVLPKW RDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTNVPNGSVMVMELDESINRYVLKTVLPKW ------------------------------------------------------------ ------------------------------------------------------------ RDVVALVTHGIYLRVFLMKWFRWTYEEFESMTNVPNGSIVVMELDETLGRYVLRTTLPKW PNILVLVSHGIWSRVFIMKWFKWSYEEFESLKNVPHCKYLVMKKDDETQKYHLKTRLLTW RDVVVLVTHGIYLRVFLMKWFRWTYEEFEAFTNVPNGSLAIMELDAEKDRYVLRTTMPKW PNILILVTHGIWARVFLMKWFRWSYEEFESLRNIPHCQYLIMKKQSEGGKFRLKTPLKTW PNILVLVSHGIWSRVFIMKWFKWSYEEFESLKNVPHCKYLVMKKDDETQRYHLKTRLLTW PNILVLVTHGIWSRVFLMKWFKWTYEEFESLKNIPHCKYLVMKRDLKASGYKLKSKLETW PNILVLVSHGIWSRVFLMKWFKWSYEEFESLKNIPHCQFLVMKKHDDDQKYHLKTRLLTW PNVLVLVTHGIWARVFLMKWFRWTYEEFESLRNIPHCQFLVMKQGPDM-KYQLKTPLRTW PNILVLVTHGIWARVFLMKWFRWSYEEFELLKNIPHCHYLIMKRHD-GGKFFLKTRLLTW PNILVLVTHGIWARVFLMKWFRWSYEEFESLRNIPHCQYIIMKQNESTGKYDLKTPLKTW RDVVVLVTHGIYSRVFLMKWFRWTYEEFESFVNVPNGSMIVMELDESIDRYVLKTELPRW PSVLVLVAHGIWIRVFLMKWYRWTYEKFESLRNLRHCEFIIMKRPEHTHKFELLNKMETW SDLEAEKDLIT------------------------------------------------- C----------------------------------------------------------- TD--CEGDLIT------------------------------------------------- C----------------------------------------------------------- TD--CEGDLTT------------------------------------------------- TD--CEGDLTT------------------------------------------------- TD--CEGDLTT------------------------------------------------- TD--CEGDLTT------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ C----------------------------------------------------------- DDV-EDDDLDV------------------------------------------------- C----------------------------------------------------------- DDL-PDSDIDE------------------------------------------------- DDV-EDDDLDV------------------------------------------------- DDL-SEAELQN------------------------------------------------- NDSDEDDELAL------------------------------------------------- DEL-PDSDVEE------------------------------------------------- DDV-DEDDIDA------------------------------------------------- DDL-PEEDIDD------------------------------------------------- C----------------------------------------------------------- HELEADERKQE------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GQCSLDDDEVYKL ------------------------------------------------------------ -----------------------------EVVKREFGDEVCFNTKNKLANP-EDFDITSI -----------------------------------------------GQCLLDDDEVYKL -----------------------------EVLKAAKEALRQVNANNDAGDVITDLELQPM -----------------------------------------------GECRSSDSEVYKL ------------------------------ELRKEFASEVNFNSKNKLLNP-EDLDIASI ------------------------------QVVKEVGDEVCFNSQNKLTNP-EDLDISGI -----------------------------YEVTKEIGDEVSFNSKNKLQNP-NDLDIHSI ------------------------------------------------------------ ------------------------------IKNSTEDSEDECMPNPDEDCLVLKAVPEKS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IQDQKDTVNSTRNKDKIIEEMYRK------AQGPESKYTDYKEKVVSRFKVDNQSVVNST ------------------------------------------------------------ IQAQRDAIKSNRYKDRQIKDAFQK--SMNTDQHEKDTYPSSPSTLASRFTLDDQSVANSV IQDQKDTVNSTRNKNKRIEEMYRK------AHGPESKYTDYKEKVVSRFKVDNQSVVNST IEAQKDAVETLREKNKKIKDTYKK-----IRSSSNSKNSRYKDKLISKFKQDTLSDCTSV IQEQRDAVNATKKKNKKLEAMYRE-------VYNDTQQNGYKNKLVSTFQMQNQSVTNSV LRAQTEAIRESRVKDQEIKQAYAQ--------------SMNKYKQLSKFMQNNQSVTNSV IEAQKIAIRQLREKNKKIKEAYDK------IHSNGNGYTDYREKMVSRFKLDNQSVVNSV IKAQTTAIREARYKDKHILHQYKK------L-MNGHG--------ASRFKMENQSAANSA ------------------------------------------------------------ VTSLTQHEKDILKKYKAAQQFHKEE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ESFH-------------------------------------------------------- ------------------------------------------------------------ SNSKHNSLENLQED---------------------------------------------- ESFH-------------------------------------------------------- ESFDDMKL---------------------------------------------------- ESFQ-------------------------------------------------------- EDVSSGC----------------------------------------------------- ENLSGQLSPTRNFSPSISGTLSPSR----------------------------------- DTLEKEP----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MSSSTNSNSSTRKSRNQGGKTDTGRPRRRQNGGSKFTK -------------------SDKLNIEAPSFVPDYRQKKGGNANTKPKPAKRGSKGNGNSH -------------------NTLNNNNKPGVPSTKRNVANRAHNYHGQGRKNKQHKLKTPY ---------------------MSNDNNPTKSGPEKESLDSRGDSKTRGRSNNAQRGRLNR -------------------NATSNSSKQGVSNNKRNPVSKAHNYHGEGRRSKQQRSRTPY -------------------NTANNNNKQGFPSNKRNATTNAHNYHGQRRGSKQQRSRAPY -------------------NAINNNNKQGAPNNKRNPVNKTHNYHGQNRRNKQQKLKPPY -------------------NAPSNCGKQAVSSNKGNPVRKAHNYHREGRRNKQQRPRASY ------------------------------------------------------------ -------------------RMGLQNTKGACGADGKARSSEAPAAGAARRRRGRGGYGSGR ------------------------------------------------------------ --------------------MANSTSNPAIIMAKDDNSVSQHKQSSQNHRQTNKNQKRQN --------------------MSQDINNNSAPNATRNKKTG-HKERNKRTGGQNKGSRQAK -------------------NNKDLIMSLTPKNDSNVPNRGSKETTSKKKSNKPPNQKVKY --------------------MANSTSTPALIVAKDDNTVPQHKLSLQNHRQTNKNQKRQN -------------------NATSDANANTIATANVVRLEQSNSSSNKNNKSKNSKSKSNQ ------------------------------------------------------------ -------------------MSNSDKTGPAIKASAHAPKKTTNDYKSLNGG---------- -------------------SVSRKTNAVKLKTPRPNAKS-----------RLNKNHDLQY -------------------HEFLACNRFDVPSTMSGNTTEGSKASALDSRNRKKGPKSNK -------------------EKNVNKLVESKSSNKNHSQNKGSQHHGKQKRYNGRGGKFPS -------------------SKNFNFAAPSFVPTEPKPSAGSKSKNGPPRKAINTPQRNNH YDLDKQERFDASIEQELNQGNMRGRKTKVSIDHLLDFQLPEVQRETHRKVNKRRID-SHT RNHGKPSALEWNIQDELAHGDLNGKKTKISINHLLDFQLPEVERFDKRRRRRQSDNQDRV KETSTDINIDLSIQEEILGGNLRGRRTQVSINHLLNFQLPEVERESSTNKKPIRRREEHV PNAYQRQKLDLSIQEEITGGNLRGRKTQVSINHLLEFQLPEIERQKKASSRHSNSD-QHA KETSTRINIDLSIQEEILGGNLRGRKTQVSINHLLNFQLPEVERESSSSKKSNRRRDEHV REASTNIDIDMSIQEEIMGGNLRGRKTQVSINHLLNFQLPEVKRESSSNKKSNRRRDEHV KETTADINIDLSIQEEILGGNLRGRKTQVSINHLLNFQLPEVERESTSGKKLNRRRDEHV KETSTKISIDLSIQEEILGGNLRGRKTQVSINHLLNFQLPEVERESSSSKKSNRRRDEHV ------------------------------------------------------------ RRGERPAQLEARIQGELQKGAAHGRRAQISIGHLLELEVGESAARPGARRRRRRGSEEHV ------------------------------------------------------------ RQSRYDHSHELNIIESQLKNGVKGSKNQISINHLLEFQYRDSEEYRRRSSSHKRPYSNKI PTRPTEGQFELNIQDEIVNGNARGRKTRISINHLLEFQLPERTKEKKKTKRSDQ---EHI SKEFGTLNFSQKIENQKSGKPGTNRKNQISINHLLEFQYKDLKEYRRNSNNLSRPANSKV RQSRYDHSRELTIIESQLKNGVKGSKNQISINHLLDFQYRDLEEYRRRSSSHKRPYSNKI DHTNRPPS-------------KKNRKNQVSISHLMNFQYRDTEEYTKRRPSKNKQDGRRV --------------------------------------MSNRHYY------------HHK --------YSDNIDNHKQNKKATSRKNQISINHLLDFQYRDSPEFNRRNPGNPKNRRQKL A-------FSQQIENQKQNKKGSNRKNQISINHLLDFQYRDLDEYRRGSNSGSRPRGALV TTAAKPPKNISDLEQQRNGKRGSSKKNQISINHLLDFSYRDSEEYTKKERRPSR---SHQ K--FTSSNLEDSIQDEIIGGNLRGRKTKISINHLLEFQLPEIERDKSKSEKR-KNV-EHI RNRQRPVPKDADAKRDLEEELLAPRKGKVNISHLLEFSPPSASRHHHSHSPHPRRKAAIK YLHGESFINVNYRLLVSDRYDYKDQENDPNKFVDKEKIVRVIVPRGQNCPICLNEPVAPR YLHGDSFVNANYKFLVDDEGSYEAQCNDPNVPLETESVKRVVIPKGQTCPICLSELISPR HLHGDSFVNVNYRLLVDDRFDYPEQSNDPNIPVDQEKILRVIVPKGQNCSICLSEPVAPR HLHGDSFINANYKLFVNDRADYREQSNDPNKLVPEEKIIRVVVPKGQNCPICLSEPIAPR HLHGDTFVNVNYRLLVDDRFDYPEQNCNPNVPVDQEKILRVIVPKGQNCSICLSEPVAPR HLHGDSFVNVNYRFLVDDRFDYPEQSNDPNIPVDQEKILRVIVPKGQNCSICLSEPVAPR HLHGDTFVNVNYRLLVDDRFDYPQQSSDPNIPVDQEKILRVIVPKGQNCSICLSDPVAPR HLHGDTFVNVNYRLLVDDRFDYPEQSSDPNVPVDQEKILRVIVPKGQNCSICLSEPVAPR ------------------------------------------------------------ HLQGEAYVNASYRFLVDPRADCAAQTVDPNVPLPADSIRRVVAPRGQACPICLAEVVAPR ------------------------------------------------------------ QLTGMRFINVNFKFVVDGRKDYRVQELDPNVPVDTDDIIRIIAPRGNSCPICLTDFVAPR HLHGDSYINANFKFLVDDRFTYEEQGLDPNVPIPHEKIVRVTASKGQSCPICLSQIIAPR HLKGMSFINVNYKFVVDYRNDYKAQQLDPNVPIDTKDILRIVVPKGNSCPICLSDPLAPR QLTGMKFINVNFKFVVDGRKDYRIQELDPNVPVDTEDIIRIIAPRGNSCPICLTDFVAPR ELTGMRFLSVNFKFVVHERYTPQLLHSDPNLPIDLEKVIAVIAPL-STCPICISSIIAPR VSSPSHFINVNFKFIVDQIR-----QEDPNIPIDTEDIIRVIGRG--SCPICLTDPIAPR YLHGMRFINVNYKFVVDYRKSYKPQQIDPNIPVDTQDILRIIVPKGNACPICLSELVAPR HLRGMTFINVNYKFVVDNRRHYHVQELDPNVPVDTSDIIRIIVPKGNACPICLTDPVAPR SLRGMAFVNVNYKFVVDCNGNYASQQIDPNIPFALEDIFQIIAHRGNQCPICLTDLVAPR HLHGDSFINANYRLLVDSRSEYKAQSADPNCLVPAENIVRVVVPKGQNCPICLCEPVAPR EFDKDAYANANFSFVVKPGE-----FSNPD-HVDMTRVVRVLVPQASDCLICLCEPTAPR MVTCGHIFCMSCLENFFEI-EEVKNPQKKKFKECPLCGSIVKPNNVKEVLFEDYSFDHRP MVVCGHVFCQTCLLQLFTNDPMVKNDKRKDLRECPLCSSIIKKTSVKPVLFDADSKDNTP MVTCGHIFCLSCLLNFFSI-EETKNKKKKKYKECPLCGSIIGPKRVKPVLYDEFDVHNRP MITCGHIFCMSCLINFFSIEETIKNPKKKKYKECPLCGSIVRRERVKAVLFDASIYDKKP MVTCGHIFCLSCLLNFFSI-EETKNKKKKKYKECPLCGSIIGPKRVKPVLYDDFDVNQKP MVTCGHIFCLSCLLNFFSI-EETKNKKKKKYKECPLCGSIIGPKRVKPVLYDDFDLNEKP MVTCGHIFCLSCLLNFFSI-EETKNKKKKKYKECPLCGSIIGPKRVKPVLYDDFDVNEKP MVTCGHIFCLSCLLNFFSI-EETKNKKKKKYKECPLCGSIIGPKRVKPVLYDDFDVNQKP ------------------------------------------------------------ MAPCGHILCMTCMLQFFAAETGRVARVRRPPKECPLCGSIVRKERCMPVLLDDAEAAREP ------------------------------------------------------------ MITCGHIICLKCVLSLLGNEVPQKKRIVEKYRECPLCFSIIRKHELKPVLMNVDERFEVP MVSCGHLFCQTCLLSFFAAAQEQKGAKKKRYMECPLCSTIIRKEKSIPVTLETDEVLKLP MITCGHILCLTCLLSLLESEVPVKKRVVEKYRDCPLCFSVIRKNEIKPVLINIDERFEVP MITCGHIICLKCVLSLLANEVPQKKRIVEKYRECPLCFSIIRKHELKPVLINVDERFEVP MICGGHVLCLLCCLRLMAN-----------DGHCPICFE--YVRNLRPVIIDEC--FERP MIACGHIVCLKCILALLESAA-----ESSATAYCPICLSVIHKHNFIPVLIYM---DENV MITCGHILCLTCLLSLLESEVPVKKRIVEKYNDCPLCGSIIRKHDVKPVQVNIDERFEIP MITCGHIICLKCVLSLLESEVPNKKKVVEKYRECPLCSSIVRKNELKPVLVNIDENLETP MLTCGHILCLRCLLRLLESELPQQKRVVEKYRECPLCSSIIRKKEVKPVRISVDERFEIP MVTCGHIFCYTCLLTFFSIVDTVKNPKQKKYKECPLCSSIIRSHNVKDVIFDNSENDQLP MLGCGHIMCLACLKRFNTQ-----------SKECPLCLENVNNAHVKPVIFGVDDERPTL EPGHEASLVLMCKPHGSILALPISLDIDPKKVGDIPPANIEEISEYSHIMKCGDDYALKY TIGSMVELQLMCRPHGSLLPLPVNLNIDPFSIGNFPSVHMKELAVYSRIMKCSTQYAIHL EPGATVNLELMCKPHGSLLPLPVALHLDPLKCGDFPPASLGSIKHYAHIMKCDVSYSLEL TPGSLTTLQLMCKPHGSVLALPVQLKLDPLQVGDFPPLTCKELEPYARIMKCDKEQSVRF EPGATVHLQLMCKPHGSLLPLPVALHLDPLKCGNFPPANLGSIKHYAHIMKCGVSYSLEL EPGATVNLQLMCKPHGSLLPLPVALHLNPLKCGNFPPASLESIKHYAHIMKCGVPYSLEL EPGATVYLQLMCKPHGSLLPLPVTLNLDPLKCGNFPPASLGSIKHYAHIMKCGVSFSLDL EPGATVNLQLMCKPHGSLLPLPVALHLDPLKCGNFPPASLGSIKHYAHIMKCGVSYSLEL ------------------------------------------------------------ VAGQEVELQLMCRPRGSLLALPVRLGVDPAAVGPFPPAGDETLAQYCRVLTCDASYARQL ------------------------------------------------------------ KVGDEVVMTLMARPMDQILALPKLLA-FDSHIRGFPDTKQFELLPYSRIFRGDSQYILEM QVGQVETFQLMCKPHGSMLPLPVMLDIDPMSLHHFPPVELSELAPYSRIMKCSSQYAVEL KVNDEVVLSLMVRPHDKVLALPSSHKEYHEVIDSFPWVNQPDFGQFLRIFKGDLHYLLNM KVGDEVVMTLMARRVDQILALPKLLS-FDNHIRGFPDTKQLELLPYLRIFKGDSQYILEM RVGEDVILKLMERQNQ--LATPVLES---ATASDFPDARDILTAPYFRFYKGDQQYLLDF KIGDDVTLQLMCRRSDQMFALPYDIA--KQNHAKFPG---MDIFPYSRVYKGDLKYALDL KPKDEIVLTLMSRSSDSIVPLPRHFESYRQAIDLFPWANQPDLSQYSRFFKGDLSYLLSM KVNDEVALTLMARPQSRIFPLPKPLMNYFDTIDHFPWINQPDCNQYLRIFKGDLAYLMDM QVNQETVLTLMYRPHASLVALPVSMEELRPLVEPFPWINSHEFDSYSRVFRGGSEYLEEM KAGSNCEFLLMCKPHAFALALPAELNVDIEKIGNFPTIQMKEVSKYSRIITCNTSYSLQL KTGDTREWTLLGRDLHDVFAAPVTAN---VTQSSIPSVESPYAS-YSRLRIGTAHWAREM YQLDMDAIENQYEIDKALYSDSGKYVKVALDKIRQNISTILSKDDFNSSINHIMNKLHFD LERDNLQIYEQLEIDKALYHDNGKLAQLALDENVSLINGLKSKNNNKEPDISA---LSIA YQKDIDAIQDQYEIDKAIYNDSGKFVKLSVENINDQISTLLAATTELNPASNDLANLHFD FQEDAEAIETQNEIDKALYGGNNKYVKEALAEIDTQIATILSEEDYEDTTSMIMERLNID YQKDIVAIQEQYEIDKAIYNDSGKFVKQSIENINDQISTLLAATTDLSPLSNDLDNFHFD YQKDIVAIQEQYEIDKAIYNDSGIFVKQSVENINDQISTLLAATAELSPFSNDLDNFHFD YQKDIVAIQEQYEIDKAIYNDSGKFVKRSIENINDQISTLLTATTNLSPLSDDLDNFHFD YQKDIVAIQEQYEIDKAIYNDSGKFVKQSIENINDQISTLLAATTDMSPLSNDLNNFHFD ------------------------------------------------------------ YMRDIEAIQTQCEIDRALYNDGGAFVAPAIAEIEERIAQC-ADDEPSLPDLER---LSLA ------------------------------------------------------------ YEEEKRDIMAAYEEEKLVYGDDSSLVAESIAYIDKEVEQW-------------LQNVVKE YKRDILNIEMQYELDRALYNDDGKFVRLAIEENKAMIALSEQASQEEGLPFNI---SQLS YELEKQTILAAYEEEKLLYNDDGKFTNLAIKNIDEDIAKWKAYYEDIEGKSSK---YAGD YEKEKRDITAAYEEEKLIYGDDSSLVVESITYIDKEIELW-------------LQNVEKQ FEMERMLVLAVDDEDKEM-------VPKGVQHIDQLLSQWPNIDDQIMPLEND------- YESEKAQILQQYDEEKLIYGDDYKLVAEALCYIDKEMDKWKQKFSVEPSNHNV---PSMS YEQEKKQMILADNEDRELYQSDGKLLQLALKNIDEDIAKWTEAFSQDLPKEQT------- YEFEKLQIRANYEEEKLLYGEDDTYFKMAVTHIDQEIANWKAEEVEEKRPTES------- FAAERAQITALQEEERTAYGEDI-FTQRALDDIDAQLEAWKTFRKDKAPVVPE--KKTIE FQNDIDAIQDQYAVDKALYNADNRFVNSAIDSINEKVTETLSRDDSLDDSFSD--QLLMK YQRELEAIFDMRKQDEYMFGDDGHFADQAVEDIMEKMELESGGDDPAAADHSLPFDLELE GNQ---SYDDTSAYFFYQTNFQYYLSPLDIKILLTIFGHYSKFPELLEVKIENIHYGNIV SGGLE-KYNDDNAFFYYEAGFNFYLSPLDVKVLKNVFAHYHEFPSTIKIKVEDIHYGSMV DDILTK-YDDTSAYFFYQTLVAYYLSPLDVKILLTIFHQYSKFPENIETTIENIHYDTVV LPS---KYDDSTAYFFYQTFFQFFLSPMDVKILLTTFHNYSAFPETLHAMVENVYYGTIV DDLLTK-YDDSSAYFFYQTLVAYFLSPLDVKILLTIFHYYSKFPESIETTVENIHYDTVV DDLLTK-YDDTSAYFFYQTLVAYYLSPLDVKILLTIFHHYSKFPESIETTIENIHYDTVV DDLLTK-YDDTSAFFFYQTLVAYFLSPLDVKILLTIFHSYSKFPGSIEATIENIHYDTVV DDLLTK-YDDSSAYFFYQTLVAYFLSPLDVKILLTIFHCYSKFPESMETTIENIHYDTVV ------------------------------------------------------------ ALP---EYDDSNAYFFYQTAFAYFLSPLDVRLLRETFGAYAHLPPVLRVRIEHVHRGSVV ------------------------------------------------------------ PNPSHTTDNSHSIYYFYETGFNYVLSPLDMKVLKTTYNDYATLPSSLVAQIENIRYEELT LDVGLEKYNDENAFFFFQTAFDFFLSPLDVKVLLTAFGRYSAFPPSLTAHVENIHFGAVV HRSKNKDLDSSNSYFYYQTGFNYVLSPLDMKVLKTNNNNYTYLPSSIVAKIENIRYEELA PSHSHATDNNHPTYYFYETGFNYVLSPLDMKVLKTTYNDYATLPSSLVAQIENIRYEELT ------SAVAAKKFFYYTTGCNYFLSPFDFKVLKHSSGQYELLPTSIVAKIEDIKV-EVL QHQQNS-----HDFYFFQTAFNIYLNTFDMKVLKSNYHSYSNLPTTVTAKIESIRYDELT -EPKESSTHSQSTYYYYQTGFKYVLSPLDVKVIKSSYNDYTQLPNSVIVKVESIRYEELT TKPVVLDVENSQSYFYYQTGFNYVLSPLDMKVLKTSYNSYTELPSSIIAKIENIKYEYLT VDP--------EPFRYYQTGFHYVLSPLDMKVLRTSYGNYSAMPTSIVAPIETIRYDELS DTNLSSRYNDSSSFFFYQTSFNFFLSPLDIKILREGFEQYSKMPLRLEMAIENIHFGDVI SPPTVGLSSPPKEFYFYAIRPNYFLAPLDIKVLKHVFGHYSMFPPSIKPRIEHVEHTS-V TEALIKRYKYLGHLPYGTEIALLDLDWRSFIEKDVYNRFASELKQRRRKLIIRKQREDQE TETTISKFKYFSHLPIGTELAFVDLDWRNIIPKEVYNKFFAELRQRHRKAMTKRNKEDKD SEQLIRRYKYIGHLPIGTEIALVDLDWRKFLPKEIYEQFAHELKQRRRKFTMKKQKEDKE TESFINRYKYIGHLPIGTEVALIDIDWRSSIPKEVYDQFAVELRQRRRKFNMKKQKEDKQ TEQLIRRYKYIGHLPIGTEIALLDLDWRKFLPKEIYEQFAHELKQRRRKFTMKKQKEDKE TEQLIRRYKYIGHLPIGTEIALLDLNWRKFLPKDIYEQFAPELKQRRRKFTMKKQKEDKE TEQLIRRYKYISHLPIGTEIALLDLDWRRFLPKDIYEQFAHELKQRRRKFTMKKQKEDKE TEQLIRRYKYISHLPIGTEIALLDLDWRKFLPKNIYEQFVHELKQRRRKFTMKKQKEDKE ------------------------------------------------------------ TDATVQRHRYFGHLPTGCELAFLDVDWRGAVPHAVFQHFAADLATRRRQLRVRQLREDKL ------------------------------------------------------------ AETSMNRYKYLSHLPLGSEIGFLECDWSNFTSTETWEIFKDDLLKRSNNSKRKLRKEERD TEHLMQRYKYFGHLPIGSEMAFVDIDWRSILQPEVYQKFAPELLSRRRKSTWKRQREDKE PESSITKYKYLSHLPLGTTIGFLECNWSQFISPETWQMYKNDLLKRTKNSSKKFRKEEKD TESSMNKYKYLSHLPLGSEIGFLECDWSNFISTETWESFKDDLLKRSNTSKRKLRKEERD DSDTIQHHKYLGHLPIGSQVSFIQCNWEGIIDSESWSLFGNDLQKRSKASKKKQLREEMN PETVRGKFKYLGHLPVGTQVAFLEIKWNNFINHETWEMFKEDLIKRSKKTKKRFNKEERD AETASTKYKYLSHLPQGTTIGFIECNWKNYITEETWATFKNDLFKRSKISLKKSRTEELN PEASLTKYKYLSHLPLGTQIGFLECNWYHFISKQAWETFKEDLNKRSKNSSRKFKREEKN PETALTKFKYLSHLPIGTTIGFMECNWRGYVNSEAWTMFKNDLTKRSQSTARKLRKEEQD THDYINRYKYVSHLPLGTEIALVDLDWRNIIPKHVYGKFANELKQRRRKFSMKQKREDIQ TIDLRKRSKYLANLPVGAEIGFVECDWRHVLPKDKLAPFAEELKQRFRRHKNQERRDDRN KKKYEERLEQEQREFYQRENSNFTGWEPQINKKDIQLTS-LPAPVKPPQNTE--AKLSKY KITYQERLEQEHLEFYQRENNNQ--YPPMQKPATQFPSKSNIALSASPDDEA--SSKPKM KKLYEKKLEQEHADFYRKENGNPLKEDSVQMATNYDSIMLGYSVLGSQEKVSPSKKKPSH KKIYEKMLEKEQAEFYRRENSNFPYQDDFEIVNSYNSIRLGPSETNLNEDETNVSKKKSY KKLYEKRLEQEHAEFYRKENGNSLKEDSVQMATHYESIVLGISMLGPPTNSCPQKQAPSH KKLYEKRLEQEHAEFYRNENGNSPKEDSVQMATNYESIVLGISVLGPPMNTSPPKKKPSH KKLYEKKLEQEHAEFYRKENGNSLKEDSVEMATHYESMVLGISVLGSPRNTCPQKNKHSH KKLYEKRLEQEHAEFYRKENGNSLQEDSVQMTTHYESIVLGISKLGPPTNASPQKKLPSH ------------------------------------------------------------ KKRYEEQLEREQSDFYQRENGSLPQAPPRPAAATFQSLV-------DPADSPADHIEPTR ------------------------------------------------------------ KKRAMNEEETRTRNFFLHENGEAE-IEQGYSTLGFGSLSDLPALSDQHVSTE----SEKE KKRYEKRLEREQEEFYMRENGNLDPEPSIVKPAKLVALP---DRSSETESKT--SKSPSR RKRAMNEEEIKKRNFFERENNGSSEYDSQIERGNFGSLSSSENVLEPSHNNESSDSSVGE KKRAMNEEETRTRNFFLHENGEAD-IEQGSSTLGFGSLSELPALSDQHVSTE----SEKE RKRALDNEEVKLKRFFMHGDDL---SDLEYNDYDTGSYRDSLSLSNQTSPTDAESDKGGK RKRAMDEEERRNRDFFKRENSNGG-DEDDEDGGSNFGMGELPALSEQPSIAD----TEGE KRKAISEGEKSIREFINRENNGLENDSENWASSSFSNLTDLPVLSNEPKTDAHSPESEKP RRRAMNEEEIRTRNFYIRENTGR--DVDDFSAADYATMGELPVLTSDHHSSNSGGDSEAE RIRALNEEELRTRAFYERENG----TNSDEMVSQFKALDLTSESMGDSEESD------SE KKIYENRLEKEHKEFYQRENGEFYNTDYSVSATSQEFLGRNSARKSDTSAYSNEHRQKSY KRLAEQRDHVE-FDTYIEQRGF---SSPPLGASA--PFGPVLGETAPTSSGETPSPSGSA NEKTIWGTSIEITEDEKTTKENKEFEDMLLQKMRQEK-------SNKKKKGKIMLFSNTQ KERTVWGTQITV-TDQNVIEEDLEFEKMLLEA------SQSKKGRSKKKGKTLLLSNNST TERTIWGTSIAVTEDERASKENKEFQDMLLQRMRQEDVPTSSGRKPKKKKGKVMLFSSNH KEKTIWGTSISVTPNDKIIKENQEFEEMLLKRMQQEDATQGGSRNGKKGKKKIMLFSNNN TKRTIWGTSIAVTEDEKASKENKEFQDMLLQRIRQEDSPTSNGKRGRKKKGKVMLFSSNH TERTIWGTSIAVTEDENASKENKKFQDMLLQRIRQEDSPTSSGRRGKKKKGKVMLFSSNH TERTIWGTSIAVTEDEKASKENKEFQDMLLQRIRQEDSLTSNGRRGKKKKGKVMLFSSNH TERTIWGTSIAVTEDEKASKENKEFQDMLLQRMRQEGNPTSNGKRGKKKKGKVMLFSSNH ------------------------------------------------------------ LQSTVWGTKILL-SEQDPSPEDAAFEQMLLQLSEEHT-RPVSGKRNKNKKSLVTLLSSNQ ------------------------------------------------------------ YETTVWGTRIP--KNEAVSSDDWEAEEMIRKAKEEMSREQAGGGKKKKKKKLVLLSS--- LEKTVWGTSIP--ASERASEEDAEFEKFLVNLNQQS--QPQQGKK-KKKKRMVTLISSNP YQTTIWGTKIPKIMNGDSDSDDWDATEMIRKAKEEINRKGKGKGKQKKKKKLVLLSSNSN YETTVWGTRIP--RNEAVSADDWEAEEMIRKAKEEMSREQAGGSKKKKKKKLVLLSS--- YETTVWGTRIKVHDDDDGTDDGEELQEMILKAKE---------KRLKKSKKLVLMST--- FQTTIWGTRIPK-TQNDPVANEYDLETAIRKAKEEMAKQEQGGNKKKKKKKLVLLSS--- SVKTVWGTTIPRGKDINGDDNDWDAEEMIRKAREEMERQSGPGKK-KKKKKIVLLSSGSA YETTIWGTKIRKAVSEQPSDDDWDAEEMIRKAREEMERSGVSGKKKKKKKKLILLSSNSG YRSTPWGTKIRK-SELEAAMESWEASEMIRRAREDM--NKENGKK-KKKKR-ILLSSNAW TETTIWGTSIDIQVDDKRYQEEKEFQEMLLQKMQEPPKNPKSKSKSKSKAKVLLFSSGGH QKKTVWGKAVNWTSEENGWG---DIAKALEAA------EAESGTR-KKGKKKLVLVSRNA QH---------------------------------------------------------- RT---------------------------------------------------------- QA---------------------------------------------------------- HQ---------------------------------------------------------- QA---------------------------------------------------------- QA----------------------------------------MNILQDKKRSKTLKSTSD QA---------------------------------------------------------- QA---------------------------------------------------------- ------------------------------------------------------------ AR---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ SR---------------------------------------------------------- WQ---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ WS------------------------------MHLRHIWAILGIYFYCGAMVAMRMSHSR W----------------------------------------------------------- ------------------------------------------------------------ QN---------------------------------------------------------- F----------------------------------------------------------- ------------------------MLSRRF------------------------------ --------------------MPSFAFKRAL------------------------------ ------------------------MISKRF------------------------------ ------------------------MIFKRF------------------------------ ------------------------MIGKRF------------------------------ -----------KIAKYWQAKRRTNMISRRF------------------------------ ------------------------------------------------------------ ------------------------MIGKRF------------------------------ ------------------------------------------------------------ -----------------MLRFSPLKCLQRI------------------------------ -------------------MFCNRMLRGSF------------------------------ -----------MLIRRLPIIPTRAIPRTSY------------------------------ ---------------MLGARRSGNLHVRRF------------------------------ ----------------MLLTRHPINVVRPL------------------------------ -----------MLIRRLPIIPTRAIPRISY------------------------------ ----------------MIATRPTVFTSRIY------------------------------ ----------------MILTRRSLISLRSI------------------------------ -----------FECGCVPISLPRASLTSRY------------------------------ --------------------------MRKY------------------------------ -----------------------MFRSTKY------------------------------ ------------------------MVFKRL------------------------------ ----------------MLRALKTRQLAPIF------------------------------ ------------------------------------------ISTSRKPFAFAFDIDGVL ------------------------------------------TRAFHTDIAFAFDIDGVL ------------------------------------------FQTSAKKIAFAFDIDGVL ------------------------------------------LQSSSKQIGFAFDIDGVL ------------------------------------------FQTTSKKIAFAFDIDGVL ------------------------------------------FQTNGKKIAFAFDIDGVL ------------------------------------------------------------ ------------------------------------------FQTASKKIAFAFDIDGVL ------------------------------------------------------------ -------------------------------------------RRLSTDVGFVFDIDGVL ----------------------------------------RPIRSLHTDIAFAFDIDGVL --------------------------SQFHTTVVNLNKGTTGCDHKGHDFAFVFDIDGVL ------------------------------------------FRQIHSDIAFAFDIDGVL ---------------------------------GHYLRCSTRRFSKVSDIAFVFDIDGVL -------------------------SQFHTAIVNLNKSTNSGNDHKGHDFAFVFDIDGVL ------------------------------NNLPLSFSVSTLARRKFHDFAFVFDIDGVL -------------------------------KRIPYHNFHTTIPRFNKDFAFVFDIDGVL -----------------------HLTFVLRMIRPSHFRFIRHLSHSSPLPAFVFDIDGVL -------------------------------------------TTGNSNLAFVFDIDGVL -------------------------------LSQLIYRQSSRQLSNTADFAFVFDIDGVL ------------------------------------------LHSTKKNIAFAFDIDGVL ---------------------------------RQRVVTRLLTTAPAAKLSYVFDIDGVL LRSKSPIPGASEGLKLLHKH-----KVPFILLTNGGGHLEKDRTSFISDALDVPISPAQI LRSKTPIPGASEALKLLNKE-----KIPYILLTNGGGVLENKRTELISDALDVEISPLQI LRGKKPIPGASDSLKLLNQN-----KIPYILLTNGGGLSEKARTDFISSQLDVDVSPLQI LRGKNPIPGASEALRLLNNS-----KIPYILLTNGGGNLESERVNFISEKLKVAISPLQI FRGKKPIAGASDALKLLNRN-----KIPYILLTNGGGFSERARTEFISSKLDVDVSPLQI FRGKKPVPGASDSLKLLSDN-----KIPYILLTNGGGLSEKARTEFISSKLDVDVSPLQI ------------------------------------------------------------ FRGKEPIAGASDALKLLNQN-----KIPYILLTNGGGFSEKARTEFISSKLDVDVSPLQI ------------------------------------------------------------ LHGEKPIPGAAEALRLLDRQ-----RIPFILLTNGGGKLEAQRTTQISKLLDVDIRPQQI LRSKTPIPGASEALKWLQQH-----KVPFILLTNGGGTLESQRTDFISKALDVSLSPLQI IRGKKPILQAKPALEILNSH-----KIPYILMTNGGGVSERRKAEEVSEITQLPISPLQI LRSKEPIPGASEALKLCQDN-----KIPFIVLTNGGGTLENQRTAFLSDALQVSLSPSQI LRGSKTLPTAKPALELLNEH-----KVPFILLTNGGGVTESARANFLSSAIGVPISPLQI IRGKKPILQAKPALEILNSH-----KIPYILMTNGGGVLERRKAEEVSEINQLPISPLQI FRGKKPIPQARSALELLNRK-----KVPYILMTNGGGISEKAKADEVTEITKCPISPLQV IRGKKPILQAKPALDILNQH-----KIPYILMTNGGGVLEKVKADEVTEITGIPISPLQV LRGSKPIPRARDALSLLNQA-----KIPFILLTNGGGVSERARVEFLSNRLNIEISPLQI IRGEKAIPGAGPTLELLNEH-----KVPFILLTNGGGVLEKERVQFISETVQVPISPLQI VRGSKPLPGAKPALELLRQN-----QVPFLLLTNGGGVTETERASFLSERIGVPLSPRQL LRSKTPIPGAGDALRLLNKN-----NIPYILLTNGGGSLEYQRAEFLSNTLDVAISPDQV MHGGEAIPQGRQALLELEQA-----QVPWILLTNGGGKSEVQRTEELSKALDFYIDPQQI VQSHTPYKSLT--------SKF--NKILAVGTPS--VRKVAESYGFKDVVHQTDIIRYDR VQSHTPFKALV--------NKH--KKVLCSGVDT--VRDVAEKYGFEKVIQPIDVLAYNK VQSHTPYKTLV--------NKY--ARILAVGTPS--VRKVAEGYGFQDIVHQTDIVRYNR VQSHTPFKALV--------PKY--DRILAVGTPS--VRHVAESYGFNDVVHQTDIVRYNR IQSHTPYKSLV--------NKY--SRILAVGTPS--VRGVAEGYGFQDVVHQTDIVRYNR IQSHTPYKSLV--------NKY--SRILAVGSPT--VRKVAEGYGFQDVVHQTDIVRYNR ------------------------------------------------------------ IQSHTPYKSLV--------HKY--SRILAVGTPS--VRDVAEGYGFEDVVHQTDIVRYNR ------------------------------------------------------------ VQSHTPYQALA--------DKY--RKVLAIGPST--VREVAEQYGFRDVVRPADVILYNR VQSHTPYKTLT--------SKY--EKVLAVGIPS--VREVAERYGFKDVVHSADIVKYNR VQSHTPLKALA--------LHHAFNRVLVLGGDGDNARHVAKQYGFQDIIMPIDIVYNNP IQSHTPFKTLV--------PKF--SKVLAVGSPQ--VRDVAEAYGFKKVVHPMDIVRYER VQSHTPMKAFA------HNNQF--DRVLVVGGDKDNARECANEYGFKDVIMPIDIVNADP VQSHTPLKALA--------LHHAFNRVLVIGGDGDNARHVAKQYGFQDIIMPIDIVYNNP VQSHTPMKALT------RDKNF--QRVLVVGGKGDNARHVAYDYGFKDVVMPIDIVRANR VQSHTPIKALA--------LNHGFNRVLVIGGDGDNARVVAKDYGFKDIILPIDIVNDNP VQSHTPMRAWA------QTGKY--KRVMVVGGAKDNSRHVALEYGFEDVIMPIDIVRQDP VQSHTPMKALA--------HKHAYDRVLVVGGPGDKARHCAIGYGFHDVIMPIDIVRANP VQSHTPMKSYI--------GQW--DRVMVVGGPYDSARKCAIEYGFKDVLMPHDLVNATP ILSHTPYRTLA--------NKY--NKILAIGTPS--VREVAKSYGFKNVVHQTDIIRYNK VQSHTPFRGLS--------GQY--ERVLVVGGDHDMSRQVAELYGFKHVIVPADIVRATP SITPFS-GLNDQQLQEYSKDKA------NLE-EKPFDAVLVFNDPHDWAADLQIINDLLI DISPFT-AVTEEHLKRVAKRHE------SLL-ETPFDAIMVFSDPKDWATDIQVISDLLN DITPFS-GLSDEQLLEYSREIP------DLT-TKKFDAVLVFNDPHDWAADLQIISDAIN DITPFT-GLNDEQLKEYSKEIP------HLD-SKKFDAVLVFNDPHDWAADLQIISDIIN DIAPFS-GLSDEQVMEYSRDIP------DLT-TKKFDAVLVFNDPHDWAADIQIISDAIN DIAPFS-GLSDEQLQEYSREIP------DLT-TKKFDAVLVFNDPHDWAADIQIISDAIN ------------------------------------------------------------ DITPFS-GLSDEQVMEYSRDIP------DIT-TKRFDAVLVFNDPHDWAADIQIISDAIN ------------------------------------------------------------ LAAPFT-GLTGQRLAREARENP------DLA-LTPFDAVLVFTESADWGGDVQLICDLLC DITPFS-AVSDARLQELSKDIK------GLD-SKPFDAVLVFNDPRDWAADIQIIADLLN SVSPHH-RYTQEEFDKFAQPI-------DVT--KPIEAIFVLNDPRDLNSDMQIVQDLLN NIAPFS-GTPTERLMEISREIP------GLD-TEPFDAVLVFNDPRDWGADIQIILDILN SISAHH-RIAAEE-FKYALSPE------KLNIEKPVSAILVFNDARDMGTDTQIILDLLN SVSPHH-RYTQEEFDKFAQPI-------DVT--KPIEAIFVLNDPRDLNSDMQIVQDLLN AVAPHS-MYTEDDFAKYSR---------DVDLSKPVDAILVFNDPRDMSSDIQIVQDVLN SVSPHH-RFTKEDFARYAQPV-------DIS--KPIDAILVLNDPRDMNTDIQIVQDLLN AVSPHH-RFTDAEFAEYARDV-------DLS--TPVDSILVFNDPRDMNTDMQIVSDLLN AVSPHH-RYTVEDFDRYSR---------EVDLKKPIEAILVFNDPRDMTTDIQIVSDLLN GISPHH-RYSKEFLDRYALSPS------EVDLDKPVDAVLVFNDCRDMGTDIQVILDLLN FITPFT-GLSNEQLLEYSQEIP------DID-TKKFDAVLVFNDPHDWAADIQIITDLLN HVWPYH-RLTEKD-DFWVLPKKECDQLVDPNGMNKVDAVFIFNDPRDWGTDVQIVMDMLL TQNGKLGTLRDSP----------SQKPSIPIYFSNQDLLWANAYK-LNRFGQGAFRFLVR SDRGYLGTLRKGS----------SEEPSIPIYFSNDDLLWANHYH-LNRFGQGAFRLIIN SENGMLNTLRGEK----------SGKPSIPIYFSNQDLLWANPYK-LNRFGQGAFRLLVR SENGLLNTLRAGSSK--------SSEPAVPIYFSNQDLLWANPYR-LNRFGQGAFRLLVR SENGMLNTLRNEK----------SGKPSIPIYFSNQDLLWANPYK-LNRFGQGAFRLLVR SENGMLNTLRSKK----------GGKPSIPIYFSNEDLLWANPYK-LNRFGQGAFRLLVR ------------------------------------------------------------ SENGMLNTLRNEK----------GGKPSIPIYFSNQDLLWANPYK-LNRFGQGAFRLLVR ------------------------------------------------------------ SERGRLNTRRDTP----------SHIPAVPIYFSNNDLLWSNGYP-VNRFGQGAFRMLIE SDGGMLNTLRKER----------SSKPSIPIYFSNNDLLWANHYK-LNRFGQGAFRIIVE SENGLIGTKRNIHHNRN------LHDPSIPIIFSNNDYVYANDYP-LPRFGQGAFRIITE SDKGMLNTIRKVG----------GSKPSVPIYFSNNDLLWANQYK-LNRIGQGAFRSVIE SENGVIGTKRSITSIND------KHKPSIPIVFSNNDFLWANDYK-LPRFGQGALRIMIE SENGLIGTKRNIHHIRN------LHDPSIPIIFSNNDYVYANDYP-LPRFGQGAFRIITE SQNGLNGVKRNFKDVKD------KSKPAVPILFSNNDYVYANDYP-LPRFGQGAFRIITE SDNGLIGTKRNIHHIRN------LEEPAIPIIFSNNDYIYANDYN-LPRFGQGEFRIITE SEGGIVGTKRQSLG---------DPTPAVPIAFSNNDYLWANDYN-LPRFGQGAFRMIIE SDHGVIGTKRSITKLKH------REDPSIPIIFSNNDFLWANDYA-LPRFGQGAFRIIVE SENGKIGTKRPVSGG--------GTEPAIPIIFSNNDFLWAADYP-LPRFGQGAIRMMVE TNNGMLNTLRNEQ----------TSKPSIPIYFSNNDLLWANGYS-LNRFGQGAFRFLVR SQDGHIGTKANWHPRPSEPT---LKSPSIPIYFSNNDLLWANQYP-LPRLGQGALRTTIE ELYSKMN----DGM-ALEDMCLGKPTKLTYDFAHHVLIDWNK---KLEAG---------- SLYSKLN----DEK-KLNDTVIGKPSKLTYDFANNVLVDWRQ---KLIDG---------- KLYSELN-----GE-PLQDYTLGKPTKLTYDFAHHVLIDWEK---RLNGT---------- NLYAQMN----NSL-ALNDLTLGKPTKLTYDFAHHVLIDWRN---KLLSG---------- RLYLELN-----GE-PLQDYTLGKPTKLTYDFAHHVLIDWEK---RLSGK---------- RLYSEIN-----GE-PLQDYTLGKPTKLTYDFAHHVLIDWEK---RLSGK---------- ------------------------------------------------------------ RLYFELN-----GE-ALQDYTLGKPTKLTYDFAHHVLIDWEK---RLTGT---------- ------------------------------------------------------------ RLYGELN----AGY-SLAHTTYGKPNRIAYDYAARVLGAWSG------------------ TLYSHLN----DGL-ALESFVLGKPTRITYDFAHHVLIDWRK---KLLEG---------- KLYKITN-GLKRHQ-HLNSLILGKPFKIQYDFAHHVLIDWQN---KLINE---------- TLYAELN-----GGSKLQNTIIGKPTKVTYDFAHHIMQRWKE---RLSEG---------- ALYKEVNKENE----KLQSEILGKPFPIQYDFAHNVLIDWNT---KMAEN---------- RLYKITN-GLKKHQ-HLNSLILGKPFKIQYDFAHHVLIDWQN---KLINE---------- SLYNHTN-RLSPLE-NLQSLIMGKPFKLQYDFAHHVLIDWRS---RLTNN---------- KLYKVTN-NLKKHQ-KLESFILGKPFKIQYDFAHHVLIDWNN---KLIKD---------- RLYRETN---RLGPENLQRTIFGKPFPVQYNYAHSVLIEWNK---ILNGH---------- NLYREVN-QLKDSQ-HLHSIIMGKPFKIQYDFAHHVLIDWRN---KLLAN---------- RLYKEQN----NGA-ELRSKILGKPFVSQYEFAAKTLVEWSG------GQ---------- ELYSRLN----KGL-ALEDTVIGKPTKITYDFAHNVLIAWRE---NLLNG---------- ALFTELT-----GY-KLRSTIIGKPVRETYEFAEETLDDWRQ---KTFNL---------- ------------------------------------------------QTDSSEINLPQL ------------------------------------------------KTDSTEQLLPRL ------------------------------------------------IARSIEQKLPML ------------------------------------------------NRTSTTQTLPVL ------------------------------------------------IGQSVKQKLPLL ------------------------------------------------IAQSVNRKLPLL ------------------------------------------------------------ ------------------------------------------------IDQSMKQKLPLL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------NTTSTSQVLPTL -------------------------------------------------DFNSEQILPIL ---------------------------------------------ETNSGAHVDMPLPSL ------------------------------------------------NTNDLNQLLPKL -------------------------------------------------DFNSEQILPIL ------------------------------------------------ELKTDLQILPLL ----------------------------------------------EHLLGNVEQVLPQL ---------------------------------------------------KPHGFMPQL ------------------------------------------------DTSSQSQFLPNL ------------------------------------------------------------ ------------------------------------------------GRNGLLSKLPNW ------------------------------------------------------------ GTPVSE--SP-FTDVFMVGDNPASDIIGAQNYG--------WSSFLVKTGVYREGDNLKH GVPPKN--SP-FEKVYMVGDNPASDIIGAFNYG--------WESCLVRTGVFADGD--KL GTKPSV--SP-FHSVFMVGDNPASDIIGAQNYG--------WNSCLVKTGVYKDGD--DL GTSPTN--SP-FEEIFMVGDNPASDIIGAQNYG--------WSSCLVKTGVYRDTDKLNH GTKPST--SP-FHAVFMVGDNPASDIIGAQNYG--------WNSCLVKTGVYNEGD--DL GIKPSS--SP-FHSVFMVGDNPASDIIGAQNYG--------WNSCLVKTGVYKDGD--DL ------------------------------------------------------------ GTKPST--SP-FHSVFMVGDNPASDIIGAQNYG--------WNSCLVKTGVYKEGDDLKE ------------------------------------------------------------ --LQTA--QP-PATVYMVGDNPHSDIIGAYNYG--------WRSCLVRNGVYRDGD---T GVAPEN--TP-FKKVFMVGDNPASDIIGAYKYG--------WSSCLVKTGVYKDGD---T GSEPTN--TP-FKKIYMVGDNPASDIKGANDHG--------WESVLLKTGVYRDEDAIDT GVAPET--SP-FRKVFMVGDNPASDIIGGHNYG--------WSTCLVRTGVYKDGD--PL NEKPTN--SP-FRKIYMIGDNPASDIMGANVNG--------WESLLLRTGVYKDAD---- GSEPTN--TP-FKKIYMVGDNPASDIKGANDHG--------WESVLLKTGVYRDEDAIDA GEVPES--SP-FKKIYMVGDNPESDIKGANDHG--------WESILLRTGVYKDED---- GTEPNE--TP-FRKIYMVGDNPESDIKGANDNG--------WESVLLRTGVY-KDDDYNT HEAPQN--SP-FSQIFMVGDNPLSDIWGANTNG--------WESILVRTGVF-KDADWDH GSEPKN--SP-FKSIFMVGDNPASDIKGANDNG--------WESILVRTGVY-DNEDLST --------RF-PPLLHGGG-------------Q----------SC---VG-Y-------- GEEAKT--SP-FDKVYMIGDNPASDIIGAYKYG--------WESCLVRTGVYRDGD--KL --------APGWEKVYMVGDNPASDIDGANRYG--------WESMLVRTGVFRDAD---L VK--PTH--IVKDVRVAVETVLEKYL---------------------------------- P-CKPTM--IVDNVLEAVTKSMERH----------------------------------- KECKPTM--IVDDVFDAVTKALEKYA---------------------------------- VK--PTM--IVDDVLNAVTNVLERI----------------------------------- KECKPTL--IVNDVFDAVTKTLEKYA---------------------------------- KECKPTM--IVDDVYKAVTKTLEEYA---------------------------------- ------------------------------------------------------------ CK--PTL--IVNDVFDAVTKTLERYA---------------------------------- ------------------------------------------------------------ LPCQPTL--VVDSVLDAVTAALQHSS-H-------------------------------- LPCKPTM--IVDNVLEAVQQGLDSV----------------------------------- EAAKPTA-GIFNNVEDAVITILESHG---------IKV---------------------- P-CEPTI--VADNVLDAVRAAMNS------------------------------------ --WDPSA-GVHDDVLESIRFALRENS--VM------------------------------ DAAKPTA-GVFNNVEDAVTTILESHG------IKV------------------------- --WDPTV-GVFDNVEDAVKLVLEKNG--VSTD---------------------------- MVAKPTV-GVFNNVEDAVIEILESHG---------IKV---------------------- TEHKPTV-GVFDNVFDGVSSVLKSLEK--------------------------------- IIAQPTV-GVFDDVYASVEAVLKSQKIL-------------------------------- ----PRR----------------------------------------------------- DGFKPTY--TVDNVYDAVTKALEGTI---------------------------------- PDAKPNA-GIYDNVLDAVRAGIKRHY---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MDGLEQQKLAKQQELAALKRI ----------------------------------------MAFETEIETKRRELNYLKHV ---------------------------------------MDSIDEQIVTKRKELQSLQKI --------------------------------------MSNQTDPQIYSKRQELEALKKI ---------------------------------------MDSIDEQIAIKRKELQSLQKI ---------------------------------------MDSIDEQIITKRKELQSLQKI ------------------------------------------------------------ ---------------------------------------MDSIDEQITTKRKELQSLQKI ------------------------------------------------------------ ----------------------------------------MVPEDVYQSKKSELLYLQKV -------------------------------------------------------MLKKI -----------------------------------MSKTNTAIYQKIAEKRANLERFREF ----------------------------------------MSLEKQIASKERELEALKKI -------------------------------MDRRTVLKSTHIQQKIAEKKAELENLNEI -----------------------------------MLKTNTAIYQKITEKRANLERFREF ------------------------------------------------------------ ------------------------------------------------------------ ----------------MTYIQHMIKSHQQSRCTTPRLSSMSSLQSKIEQKREELENLQEL -------------------------------------MLKNIYHQKIAEKKADLARLQEF ----------MRSGARNPHILVSVILPLLILLAMEKPLKSTHIQQKIAEKRAELENLTEI -------------------------------------------MSAVQAKRAELDYLRKI -----------------------MVRPRVSLAPNRLNHAGSELDEKIAAKKRELQQLVQL TALTDQMRTELDEMSIEVSKINKNAESVANVMANWDSIRKYISEAS-------------- SALTQKLKAQLDELSVQVAQMNSNAVTVKDVMANWDSVLRSISQAS-------------- TSLTDGLKLQLVELNEQVKEIGTNAEAVAQLMNNWDSIINNISQAS-------------- TALTDTMKLQLGELSEQVQMMENNVDSVARVTAIWDSVMKSISQAS-------------- TSLTDGLKIQLTELNEQIKEMGMNADSVAQLMNNWDSIINNISQAS-------------- TSLTDGLKVQLMELNERVKEMGTNAESVAQLMNNWDSIINNISQAS-------------- ------------------------------------------------------------ TSLTDGLKIQLTELNDQIKEMGTNAESVAQLMNNWDSIINNISQAS-------------- ------------------------------------------------------------ TGLTDTLKAQLDELSKQVHQMHDNAECVSSVLKNWDSILNSISQAT-------------- NTLTESMKQQFDELAIQVAKMHDNAEGVAQVMKNWDSILKSISQAS-------------- KELTDDLVLQLESIGDKLETMNGGTASVALILANWKSVVQSISLAS-------------- NSLTGSMRVRLDGLASEVKIMHENAENVAKVLHNWDSIVRAISQAS-------------- KKFTSILTNQLDELENKLDYMAEGTESVALVLSNWQNVVKSVSLAS-------------- KELTDDLVLQLESIGDKLETMNGGTASVALILANWKSVVQSISLAS-------------- ------------------------------------------------------------ ------------------------------------------------------------ KKFTEILVKQLEQIEEKFATMADGAESVSLVLSNWKNVMNSVSLAS-------------- RELTGELASYLESIGNNLETMKGGAEGVALILANWQNVIKSISLAS-------------- KNLTQNLTSQLKDLETKLSAMSDGTETVALVLSNWQNVVRSVSLAS-------------- TALTDTLKSQLDELSVQVSQMNNNASVVEQIMENWNSILRSISQAS-------------- RQYSSDLADELEGLVQHVSCLAEETDVVAEVMGNWAAVIRAINLAS-------------- -------------------------------------------------------LGLLR -------------------------------------------------------ISLLQ -------------------------------------------------------LGLLQ -------------------------------------------------------LGLLQ -------------------------------------------------------LGLLQ -------------------------------------------------------LGLLQ ------------------------------------------------------------ -------------------------------------------------------LGLLQ ------------------------------------------------------------ -------------------------------------------------------LSLLQ -------------------------------------------------------LSLLQ -------------------------------------------------------LALMK -------------------------------------------------------LSLLQ -------------------------------------------------------LGLLK -------------------------------------------------------LALMK ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LGLLK -------------------------------------------------------IGLMK -------------------------------------------------------LGLLK -------------------------------------------------------LSLHN -------------------------------------------------------TALAR Y------------------------------AEGDYQVGAWDG----------------- Y------------------------------TENDYETGKWAS----------------- Y------------------------------AEGDYEIGPWED----------------- Y------------------------------AESDYEVGVWDE----------------- Y------------------------------AEGDYEIGPWKD----------------- Y------------------------------AEGDYEIGPWKD----------------- ------------------------------------------------------------ Y------------------------------AEGDYEIGPWKD----------------- ------------------------------------------------------------ Y------------------------------TENDYEVGAWSN----------------- Y------------------------------SEGDYEVGKWDT----------------- E------------------------------SNDNNKE---------------------- Y------------------------------SEGDYEVGIWDQ----------------- Y------------------------------SEKDYETGA-------------------- E------------------------------SNDNNKE---------------------- ------------------------------------------------------------ ------------------------------------------------------------ Y------------------------------SSKDFKENV-------------------- Y------------------------------SDKDYTTDT-------------------- Y------------------------------SEEDYKNGN-------------------- Y------------------------------SQGDYQVGAWNE----------------- Y------------------------------TEEDYRE---------------------- --------------------------KENKSDKSNADKSYQSDDEHKTEPL-PEALVR-- -----------------KEEHRNQQGAEDESAASESSEDNQQRQQDQLPPL-PETLVR-- ----------------SKKSESEQQREKDLESHEENENDDDNDEEEDLVPL-PETMVR-- ------------------------SSQGKNRRLDNDEDSQLENENEKVLPL-PETLVR-- ----------------SKKKESEQSNETGLEAQENDKNDEDNDEDEDLVPL-PETMVR-- ----------------PKKNESEGPDEVDLEAQESDKDNDNNEEDEDLVPL-PETMVR-- ------------------------------------------------------------ ----------------SKKNESERSDEAGIETQESDKNNEGNDEDEDLVPL-PETMVR-- ------------------------------------------------------------ ---------------------------------------GSRPEADKEPPL-PETLVR-- ----------------------------------------SNDNQEKEPPL-PETLVR-- -------------------------------------------------AF-PEPLVR-- ----------------------------------NPNEDEEEEEREKERPL-PETLVR-- -------------------------------------------------PL-PECLVR-- -------------------------------------------------AF-PEPLVR-- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------PL-PECLVR-- -------------------------------------------------PF-PEPLVR-- -------------------------------------------------PM-PEPLVR-- ----------------------------------------NDDTKDENPPL-PGTLLR-- -------------------------------------------------PVLPEQLIR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ISVANNEESRK---------------------- ---------------------------VKVADDVE------------------------- ---------------------------IRVDGNE-------------------------- ---------------------------ITAGEEADNTPDINQDVAEEIREPSIEL----- ---------------------------IRVDGNE-------------------------- ---------------------------IRVDGNE-------------------------- ------------------------------------------------------------ ---------------------------IRVDGNE-------------------------- ------------------------------------------------------------ ---------------------------VNVANESQE------------------------ ---------------------------IRVNEDDQ------------------------- ---------------------------VRVGQSNEENQDEEEADEE---EGVRDS----- ---------------------------VKVDQEGSGNIQ--------------------- ---------------------------IKLDKDDNVGEEIQEKEEMETDDYILDQQAEES ---------------------------VRVGQANDENQEEEEDDEEDEDEDVREN----- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------IKLDKDDEPDIEGDKEESGVAKSPQGDK----- ---------------------------IKLDRDDETTEDNEEGSSQIAAGIASDDRAS-- ---------------------------IPLAKEEE------------------------- ---------------------------MRVDGDTTNVD---------------------- ---------------------------VPLEDEQEE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------EEVEESTE------------------------------------------ ------------------------------------------------------------ ENINEEEDRQEVQTSYTD------------------------------------------ ----------EEIEESMQ------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TEGSQVQLFLESGNE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------MRHQ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MH ----------------------------MGLCEVCNVEEFKYKCPRCFKKTCSLACSKQH KLVRVITLDCNTIPSTSHLDLSKKKTDMDDKCMVCLNETWKYKCPRCLKKSCSLACSKKH ----------------------------MVLCGVCGINEFKYKCPRCLAQTCSLECSKQH ---------------------------MPLLCEICHKNEFKYKCPKCLKKTCSLACSKEH ---------------------------MAVLCGVCGIKEFKYKCPRCLVQTCSLECSKKH ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MTTVLCDVCGIKEFKYKCPRCLVQTCSLECSKKH ------------------------------------------------------------ ----------------------MTSTTSCEGCEVCKTGEPKYRCPRCSRRTCSLACSRQH ---------------------------MDRKCQICQVEEFKYKCPRCFRKTCSLLCTQTH ----------------------MDFEEETTVCTICHENKSKYTCPACEIKTCSLSCYNKH --------------------------MVDSTCEICLVNERKYTCPKCSKKTCSVGCIKTH ------------------------MVSENLVCSICHLNEHKYTCPACGVKTCSINCVKRH ----------MAHRLAYIQFLSMDFGEENTVCTICHENKSKYTCPACEIKTCSLQCYNKH ------------------------MEESLELCLICLSNRAKYTCPACAYKTCSLFCYKTH ------------------------------------------------------MCLKGP ----------------------------MEQCSVCLEKDFKYTCPACGTKTCSVECVKRH ------------------------METEQALCAVCHINNFKYTCPACGIRTCCIVCVKRH ---------------------------MAPVCGICSKEPSKYKCPSCGMQTCSLECVKLH ---------------------------MSQLCEVCGLNEFKYRCPKCLKRSCCLECSKKH ELKRFTIQKKEKNHTHTHTHTHTQTTTHSMSCSICQ-QESKYRCPACSARTCSLACSKQH KADESCSGKSHDPTAYIPRTDIKEADDENHESNILVQRDYNYLINMRREVEVQIDDSKRK KETDNCSGIS-NATEYVSSQNLKEADTSE-EMNHLVQRDYNFLIGMNRRLAVLKEDGKSK KARDDCSGQTHDPKDYISSETLKHADDEKHERNAYVQRDYNYLTQLKRMVQIQKMDARVK KKTDACDGIAHDPTKYIPHEKLKDADDEKHESNPLVQRDFNFLNSLKRTVELQKMDARTK KTRDNCSGQTHDPKEYISSEALKQADDDKHERNAYVQRDYNYLTQLKRMVHVQKMDARMK ------------------------------------------------------------ ------------------------------------------------------------ KTRDNCSGQTHDPKEYISSEALKQADDEEHERNTYVQRDYNYLTQLKRMVNVQKMDARMK ------------------------------------------------------------ KEQENCSGTSGQTTEYIPRGVLKGADTKD-ETNPLVQRDYNFLIGLNRKVQLLKEGSSQK KSQHNCPGTAQEPTKYVSKSELKQADTED-EQNLLVQRDYNFLIGMNRKLDVLKKDGKAK KYERDCTGKV-DSNKYLNRNELA-------ADPVHLNRDYNFLNNVDRKIHVGKEDIIKS KSQDNCSGMTADPTGYVPRQKLKEADTPD-ETNVLVHRDYNFLLGMNRKVELLKRDGKTS KRQTECSGLV-DQSKFVPKKILS-------QDESHINRDYNFLMNVGRQIHVGKGDIKSS KYERDCTGKV-DSNKYLNRSELA-------SDPVHLNRDYNFLNNVDRKIHVGKEDIVKL QREQSCTGKV-DVTRFVTRDELS-------QTPVHLNRDYNYLQNVDRKISLSKEDIKSN K--------------------------------------FSHHNTINKRQRRIDEDNKDK KLRSECTGQV-DPTKFVPKKKLS-------ADQALVNRDYNYLLNFERTVQLGKSDIKVN KKQNECTGVV-DKTKFVGRKELV-------ESASHLNRDYNFLLNVERQIQLGKGDIKSS KKEKNCSGFV-DPAKFLSWKQLS-------EGSIHVNRDYNFLINAGRHLDVQKETLRSK KFDEDCSGLKYESTEYISSEVIKGADDEKYESNHLVQRDYNFLMKIKRDLELSATDSKMK KASEKCSGLP-DPTKYLNREAL--------FTDTSVNRDYRFLKRLERDIVVRKQDGE-- NKRILREIY----------------------DPYMAN----KR---------------QR NKRVLQKV-----------------------PGVTGP----SRYNVSK------------ NKRVLGPAG---------------------HSASLKR----RRYGADE----------DD NKRALMSST---------------------NNHANKR----TRFN-------------NS NKRVLGPVG--------------------GHNSNFKK----RRYDIDE----------DD ------------------------------------------------------------ ------------------------------------------------------------ NKRVLGPAG---------------------HNANLKR----RRYDMGE----------GD ------------------------------------------------------------ NKNIVHA----------------------------------GRGDG------------GH NKRALYSS-----------------------NYNSSK----RHHGIRN----------DE AKNVFKRTR-----------------NQSQASGNKRH----KRNEEDN----------TD NKRVLSAHH----------------------HGQHAQ---------------------KR AKNVFKRQF-------------------GG-GNQNKN----KRFKGNN----------VD AKNVFKRTR-----------------NQLRAPGNKRH----KRNDEDN----------TD ARNILKRSR-------------------NEVMQDRRQ----KRVKRNDGGVNGNVNNFKN RITAVEKVF-------------------------------------------------LN AKNIFKRGA----------------------GQNQGH----KRQKVESE---------KD AKNMFKRNF------------------NSGNSINSGN----NRKSTSE----------DD SKNLFKRQG-------------------GP-GKRPPP----KRQKTES----------ED NRTILQQQG----------------------KGNYRV----SK---------------PV SMPIFKRAR----------------------YNQNRK---------------------DG GNSDNSSRLI---------RRGVSCLMLPKGMQRSLQNKSKWDNSLNQFTWTIEWVLCG- -----PPRVM---------RRGVKCLLLPKGMQRSISNKSKWDKPLDTFVWSLEWVLFD- HDDMECQRII---------RRGVNCLMLPKGMQRSSQNRSKWDKTMDLFVWSIEWILCP- NDESGCPKVI---------RRGVTCLLLPKGMQRSAQNRSKWDKSLDLFVWSIEWLLCP- RDSTECQRII---------RRGVNCLMLPKGMQRSSQNRSKWDKTMDLFVWSVEWILCP- ------------------------------------------------------------ ------------------------------------------------------------ CDSTECQRII---------RRGVNCLMLPKGMQRSSQNRSKWDKTMDLFVWSVEWILCP- ----------------------------------------KWDKPLDLFVWSMEWILYP- GRVGKPGSVV---------RRGVRCMLLPKGMQRSLWNKSKWDKSLDTFVWTIEWAVAR- TTEPQVNKVI---------RRGVQCLLLPKGMLRSLQNKSKWDKPLDCFVWSLEWCILQ- KRITAVKKIFLNDPNISIKRENTLIVSLPIGMSRSNTNKTGFDKKLNSFVWTIEWIMLN- GHFEQPPKVI---------RRGVHCVLLPRGMQRSLQNKSKWDKSLDSFVWSIEWCLFA- SQEAVDTRIELQEPTTVIKRNNTMIIQLPPGMSRATSNKTGYDKKVGSFIWTVEWVVID- KRIMAVKKVFLNEPTISIKRENTLIVLLPIGMSRSNTNKTGFDKKLNSFVWTIEWIVLN- SDNGEDRRRIPQNPSIVIKRQNTMVVQLPLGMQRAVSNKTGYDKKLNTFVWTVEWILLD- NPTTIVK------------RENTLVVQLPAGMSRFSSNKTGYDKKLGSFVWTIEWIVLN- PRIEKVNQIFPHQPQTSVKRQNTLVIHLPPGMSRATQNKSGYDKKAGAFTWTVEWIPVD- ARLATIKEVYPNDPAVVVKRQNTLVIQVPSGMTRATTNKSGYDKKLGSFIWTVEWILLG- FRIQLIKRAFPHDPPTSIKRKNTVIVSVPPGMSRAMANKTGYDKKAGAFVWSVEWVVLA- SVSSECHSVV---------RRGVNCLLLPRGMQRSLQNKSKWDKPLDLFVWTLEWVLFP- KDGSVME------------RNGVKIHKVAQGMGRQKRNHSRWDPNIKQFCWTVEWVNVD- --------DGDTVTHLTHRAKENESVVEGISKIVF----------NKIQTFYKI--ENGD -------QKDEHWSHLSHRNKEESELVHCIGKQVY----------DKCKEFYRGAEEEED --LQAQGEDKQVFKHISHRIKETDFLVQGMGKNVF----------QKCCEFYHFAGTSGP --------------PKNRVVPLQEDVQEGVQKGVQ------------------------- --MQEKGEKKELFKHVSHRIKETDFLVQGMGKNVF----------QKCCEFYRLAGTSSC ------------------------------------------------------------ ------------------------------------------------------------ --MQEQGEKKEVFKHVSHRIKETDFLVQGMGKNVF----------QKCCEFYHLAGTNSC -RKQASSTQEEPFSHISHRIKETDTSVEGMGKIIY----------DKCCEFYHLIKEDEP -------PGGEQWTHCSHRNQEQSRLLDCIGKAVF----------DKCAEWLPLAAAGDD --------PDSKFAHTSHRNKETDSLVDCVGKSVF----------DKICDVFQLEEDSNV ------EQGEQVTKFISYRLKESLVLQDSVPMNII----------NNKFTKPVE------ ------PDGTIEYTQTSHRNKETDSLFDCIGKSVY----------EKCHSLNGLEPVPEG ------DAGKEKDRFISYRLKEHLLLRDAVPMNIL----------SNAVSVNGEGDSARN ------DQGEQMTKFISYRLKESLILQDSVPMNII----------NNKLNQPVE------ -----NDQGKQLDSYTSFRLKESGVLKEIVPQVLL-----------SRNGFDALPFSSCP ------DEGKQVSKFLSYRLKEGLALEEAVPMNIV----------NNNFPTEME------ ------ATGCTRKPFISFRMKETLPLKDAVPMTVF----------ENAIGANVD------ ------SKGEVVSQFLSYKLKEHLILGDAVPMNIL----------NNSKSEKTKTINNEE ------DDGQEIGRYMSYRLPEGNTIQQLVPINLI----------KKAHGDESDLIV--- ---MSGDNGNDVFSHLSHRVKETNTVVESMGKIIF----------NKCCEYYNLSKADTD ----------TNETMTVDKVNPVQSLLECFQKRGS----------EKGGNGDNKGERKVE GDETQAVLSREDRIALIK------------------------------------------ KENSATTKEDRSSQMI-------------------------------------------- EEGEDGSETKEERTEILQ------------------------------------------ ------------------------------------------------------------ IEGEDGSETKEERTQILQ------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EEGEDGSETKEERTQILQ------------------------------------------ APETKPERTQCLV----------------------------------------------- GEPLTKASRLQALV---------------------------------------------- ESSKQTRSDRLL------------------------------------------------ ------------------------------------------------------------ STKQTRIESLA------------------------------------------------- ID---------------------------------------------------------- ------------------------------------------------------------ GSSADADADAR------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ KHKGEQQYNKIDID---------------------------------------------- ------------------------------------------------------------ -DKANGVETKQERTDLLV------------------------------------------ KNDTEQTEMKDEHSKQKDGDKKDEEKEVVP------------------------------ -----------DYNLEFYIKWFPYNSTEMSDSRNLIRIDAVNSTLGDVFKNRTVIEFPTI -----------EFGFRFFTKWFPNNVESIMDTKEVVEID-PKKCVGEIFRDMTVIEFPTI -----------KSGLKFYTKWFPYNTTHITDSKKLVELPIHEKCIGELFRNMTVIEFPTI -----------EDFVQFVSHRIKE-----------------TDSIVDGMSNVVYEKCSKL -----------KSGLKFYTKTFPYNTTHIMDSKKLVELAIHEKCIGELLKNTTVIEFPTI ------------------------------------------------------------ ------------------------------------------------------------ -----------KSGLKFYTKSFPYNTTHIMDSKKLVELTIHEKCIGELLKNTTVIEFPTI -----------KGGLKFYTKWFPYNTIRITDSKQLVELDPCQKSIAELFKNRTVIEFPTI -----------GSGLRYYTKQFPAETEGVIDTKRVVELD-PQKAVGELFRNKTVIEFPTV -----------SSGLRFYTKWFPKDTSIMMDSKKLIRLD-PSKCIGELFRDKTVIEFPTV -----------KCYLKFYLHDVIHKG-------KMIRLN-GGDKISDVLKDKIVLEYPTI -----------ASDLKFYMKQLSHAMETFADSKKLIPID-PTKSIAESFRDKTVIEYPTI -----------KEQLHFYLANVVGNDNTK---DSILHLN-EADLISDALTNKIVLEYPTI -----------KSHLKFYLHDVIHKN-------KMIRLN-SEEKISDVLKDKIVLEYPTI -----------SPQLYFFLRNVANKPINS-----LIQLS-SNAILSDALKDKIVLEYPTI -----------KHQLKFYLHNVIFKEK-------LIELD-NKSTISSALKDMIVLEYPTI -----------KDTLHFYLDNCISGKEGN----EVIALD-PQMSLASALSNKIVLEFPKI -----------KSQLNLYIDNVLSSDKSQ---RSVLVLD-KQMTIAEALKDKVVLEYPTF -----------PEKLSYYLMNVVNCKPGR----SLIPLEAP-MPLCDALADRIVLEYPTI -----------NCGLKFYTKHFPEHIPTMMDSKKLIEIEPSNVCIGEIFRNKTVIEFPTI -----------LTPRSFYMKRIKSKNTSP------ILLD-PSKPLSENLKDKSVVEYPTI YITKSA-QELPK----------GFKVMIEEKGSAP------------------------- FIVPDM-ETLTK---------HGFHLHVEGSIDTPQATSTTTTTAPIPVISESHYPVEYS FIAMTE-DDLPE----------GYEAVHEETHRTE------------------------- FNFP-------------------------------------------------------- FVAMTE-ADLPE----------GYEVLHQEPRPLE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ FIAMTE-ADLPE----------GYKVLHQEPRQVE------------------------- YVVANE-SELPE----------GYSIVDEQAMQEA------------------------Q YIAASA-EDMER---------LGFRVASDGTTTSS-----------------------SD YVAKDD------TS-----IGSDFKLVHDSSGDSS----------------SSEESSSSS YVAAND-ECLQDRI------IDSLQLAEEEEDDTT--------------DSSEDDSSDSE FIAKNG-----------QSMKCGYSVLGEGSESSS--------------------SESES YITFNA-ETWKNRI---IKEEDAYNYAKPESLSES---------------GSSDDSDSDD YVTAND-ECLQDRI------IDEFQLADEEDDDAT------------------GSSTDES YITTNV-KSVQNRI---VSEIQGYGLRGDSDQSSS-DSDSDTGSEVSSSSGTGSDSDSDS YIAAND-EQLRTKI---ADKDSIYGLQEDEDTKNS----------------------SDD YVGVDD--SMDKYV---CSENKAYGVDGSDSEKSE---------------------SATD FITTSE------------KVIENAVVLIEEAYKIK------------------------- YVSQSG-TNVGDIC-------TSYNQSLTDDEDSS-----------------------SD FVALDV-NDIPS----------EFEIVGRKTDVVE------------------------T YYTNEE------------------IVASDSDSDSD------------------------S -GAEENSRVNVAGSGSSSDTETDDSDAEPEEESSKQDNTQNKNVVVENVSEATAT---VD VIDPKPQASLDVAKSSDSTSSDSVSDSDADLDSDSDSSAPEE----------------GS --TDKHTNPLNKFVDDVRETEDAARDTQPAEEPVQKEGPDDVKG--------------GR ----------------------------PLEKGVKX------------------------ -----HTSTLNKFIDNAREEEDAEEDSQPTEEPVQKETQ-------------------DA ------------------------------------------------------------ ------------------------------------------------------------ -----HTNTLNKFIDDVREEEDAEEDSQPTEEPVKKEAPNAS----------------NN KSSDSDSDSDSDSDSSDSDESESDSDAEPQEESSKAQASTSGSA--------------VA SSDTSSSDSSDSSSGDSSSDSDSSSDGEPEENPARLEPAPPPAS--------------PS KDSSSSNDDSESASSSSSSSSSSSDDESPDENPSKPS---------------------KK SDDDDSDSGSETSSIGDGSGEDNDSDSAPEETSSKLPP--------------------FS SDSSSADSDSDEDSSSSGEESSNSDDDEPPETTSKQPPVYQSI---------------KE SSDSDSDSDSESDSDEKNTDNETDSDEAPEESSSKPLK--------------------VT SSSDDGDSDSDTSSVGDSSDEDNDSDSAPEETSLKLPP--------------------FS ELDSDADADADADSDTDSRDASESEDSGPEEASLKKLEIEVGDDFE------------EQ SDSSDGSDDSSSDESDSDSDSGSDSDSAPEEESSKLPPLKTS----------------ID SDSDDSDSDSDSDTDSEDSDSDSDSDSGPEETSSKPDNVELVR---------------DA KNVEESESGSHESDSDSSSNSSESSDSDSSSESLD-----------------------ED SSSDSEDSSDPDSESDSGSESEDSDDSAPEESSSKPP---------------------QL QEEESGSDSTSSSSSSSSSSSSSSSDEAPMEEPSTNNGASSTCFRNTE----------TN DSDSDSGSDDSDDSDDSDDDSDDDSDSAPEEESARQPEMPDI----------------VK KDTSDEEDDD------YNPGVSLDFLMS---QTIQLIYLICALLGTALCAPYEAYPIPKQ AKRHSDSEDD------YEVGVSLDFLTA---TELLLSSALSLLFAVASASVYEAYPINKQ DSDSDSDSDD------YNPGLSMDFLTA---QLSLLLVPIISLFHLVVATPYEAYPIGKQ -------------------------------TIFPLLLIISRLFSLTYAQPYEAYPINKQ SDSDSDSDDD------YNPGLSMDFLTA---QISLLLTATISLLHLVVATPYEAYPIGKQ -------------------------------QFSFLLIAITSLFHLVVATPYEAYPIGKQ ------------------------------------------------------------ SDSDSDSDDD------YNPGLSMDFLTA---QISLLLIATISLFHLVVATPYEAYPIGKQ RQESDDESDG------YDPGVTLDFLAG-------------------------------- HGGETDSDDG------YTPGISLDFLAD---VRILLIARLLVLVR---GLLTEAYPISKQ EAVLPESDDD------YTPGISLDFLAD---WTHFLLLLLVPCVSVASAQPYEAYPISKQ QKFFEASAEPKPIIEEIGSNKTVEEP--------------------------MGFPFNEQ PQVEEDDEDD------YTPGISLDFLAD---MRGARLILVSTLASLARTEPYEAYSVDSQ FDAEAPTQNA------PEANKSEE-------TLYLLVFFCLDLIRISYGSVYIGFPLNEQ QTFFETRSDLKPIIEEIGSSEVVEEP----------------MSPLIQASIYMGFPFNEQ KYDNIEKKDLVTSLVEVGDVCTVGDVAGESSLYLIYLLLLLQLTSHVHATIYMGFPFNEQ DDRRVLNKPI------IEVIESTKNEKQE--MLYSIILLISLFLQLINASIYMGFPFNEQ GELTEVIAEP------VESKLTGDEEKSL---MLALLLFLLAHA----SAVYIGWPMNEQ DGPEEESSRP----------------------MLFILVFLMAIAS---AQIEVGFPFNEQ SNTEEIEVDM------------------------MLLGFLLLFVRAVAASVYLGFPFSEQ ESDCDSDSDD------YTPGVNLDFMAF---LSKYLLFFIISISRLVSCYPYEAYSINKQ TLADSAVNDMAGLEDAFEKAQEEGKQ-----DTPKMLVKSLLLATAVVAAPSAGYPFNSQ IPPVARTNQQFVFQISNDTYKSNVNQISYQTYDLPKWLTFNTDSRTIQGLPPSDLFNGFK LPPIARVDEDFQFKISNDTFKSTNEQISYESSELPNWLSFDSSSLTFSGKVSSDFLDDFD YPPVARLNESFTFQISNDTYKSSADQITYDCYDLPDWLSFDTGSRTFSGEPSSNLLSDID YPPVARIDESFSFQLSNTTYQSSNNQITYQVFDLPEWLTFDTQSRTISGSPSAALLDDFN YPPVARVNESFTFQISNDTYKSSVDQITYNCFDLPSWLSFDSSSRTFSGEPSSDLLSDFN YPPVARVNESFTFQISNDTYKSSVDQIAYNCFNLPDWLSFDASSRTFSGEPSSDLLSDFS ------------------------------------------------------------ YPPVARVNESFTFQISNDTYKSSVDQITYNCFDLPNWLSFDSSSRTFSGEPSSDLLSDFN ------------------------------------------------------------ FPAVARVGQEFQFELSENTFQSDKGKVQYAVSGQPKWLNWDGSRRLLYGTATREYVGAFD YPPVARIGEDFAFQLSNDTYKSSRDQISYQVYDLPSWLSFDSQQRIISGTPTKDDWDSFE LPNIGRVNKDYSFTIANTTYKSNSDVISYQVENLPSWLSFDSSSRTFTGKPQESDVGSFE YPPIAIAGEEFSFKLSNDTFKSRSDEIQYEAFDLPSWLQFDSTNRVLSGTPSTDDLPNVS LPNVARVNEAYLFTMANTTYKADG-EVSYSASNLPDWMSFDGGSRTFTGTPSKKDAGEFN LPNIGRVNQEYSFTIANTTYKSNSNEISYQVNNLPSWLSFDSSTRTFTGKPQESDVGQFE LPNVARVNEAYTFTFAKSTYKSTSENIQYNVTSLPSWLSFDSESRTFTGTPDSSDEGEFQ LPNVGRVNEDYTFTIANTTYKSNSHEISYEVENLPSWLSFDSSSRTFSGKPEESDVGEFE LPNVARVDQPYSFTLASTTYKSNAGTISYSVSGLPHWLSFDSQSRSFSGTPSSSDVSTFE LPNVARIDTAYSFTMANITYKSDNFVISYQATGLPLWLSFDSDSRTFTGTPSKDDVQEFE LPNVARVNQSYTFTMANTTYKSSDGTVSYSASNLPKWLSFDSGSRTFSGTPSKDDEGTFE YPPVARINETFNFQISNDTYKSNNGQISYQVYGLPTWLSFTSDTRTFSGTPPSKLLSDFP LPPVARWGQNYAYTLPRDTCTGDG-EISYSADQLPSWLSFDGNN--FSGTPEGGSSDEIF FILEGTDESDNSKLNNQLVVTNKPAITLSPNLLALLKNSGYTNGKNGLILTPNQIFNVTF IILKGTDSTDSASFNTQLVATKKSGISLADDLLNLLKNYGYTNGKDALKLSPGDIFNVTF VVLEGTDPTDSTSLNNQFVVTNRPTISLSSDLLALLKNYGYTNGKNALKLSPNEVFNVTF FILQGFDETDNSYLNNQLAVTKKSSLQLANDLLALLKNYGNTNGKEGLILAPNQVFNVTF VILEGTDSADSTSLNNQFVVTNRPSISLSSDLLALLKNYGYTNGKNALKLDPNEVFNVTF VILEGTDSADSLSLNNQLVVTNRPSISLSSDLLALLKNYGYTNGKNALKLDPNEVFNVTF ------------------------------------------------------------ VVLEGTDSADSTSLNNQFVVTNRPSISLSSDLLALLKNYGYTNGKNALKLDPNEVFNVTF ------------------------------------------------------------ IVVEGTDVGDGTTLQQRLVATSRMAPRLAPGILNVLKQSGNTDGRNSLKVLPGESLNVVI FILEGTDAADNSALNKELVVTNRTSLSVSSSLLSLLKNYGYTNGMDALKLSPGDVFNVTF ITLIGTDSTDQSQLSNTMMVSNDTGLYLTSQLYSELSKSGQTNGNGGLVVKPGDKIKIQF YTLQGTDPEDEQKLNKNLALSKKSDIAVSTSLLSLLKNSGYTNGRNALKLSPGEIFNISF ITLTGTDSDDGSTLSNSMIVSEDEGIHLSSDMFTEIAKYGYTNGNDGLVVNEGDKFDIKF ITLIGTDSTDQSQLSNTMMVSNDTGLYLTSTLLSELSKSGQTNGNGGLVVKPGDKINIQF ITLVGVDQLDDSSMENSMVVSSLPDLDSNSFLYDELTSMGQTNGGDGLVLKQGDEFSFTF ITLTGTDSSDGSQLTNSMIVSNDTGLYLTSELFNELAQTGQTNGVDGLVVKPGDTIKIQF ITLNGTDSADNSVISRSMLVSNSTGLRLSANMFVAIAKYGQTNGKDGLVVREGENFSIQF IHLFGTDSSDGSTINNSMIVSNDTGLHLSSNMFTEIAKYGDTNGNDGLVVREGQEFNISF ITLSGTDSSDGSTISNSMIVSADKGLHLTSPMFTQIARYGDTNGHDGLVVKQGQQFSLKF IILEGTDEADNIGLNNQLVVSKKTSIEVASDLLALLKNYGYTNGADGLILSPYEIFNVTF FQLKCKDASGQEATSEKLIISSAQPPKLNPGLVQQLAKFGPTDGGSGLVVKPNEHWSVSF DRSNFDSSDEIVAYYGRTQYNAPLPNWVFFDPANLKFSGSAPVVNSQIAPQTAYDLTLIA ERDNFDSNDSVVTYYGRSQYNAPLPNWVFFDANNLKFSGSAPVVNSDIAPEMDYSFNLIA DRSMFTNEKSIVSYYGRSLYNAPLPNWLFFDSDELKFTGTAPVINSEIAPETSYDFVIIA DRSAFVNQSSIKAFYGRSQYNAPLPNWLFFDSSDLRFSGTAPVVNSAIAPEFSYGLVLIA DRSMFTNEESIVSYYGRSLYNAPLPNWLFFDSGELKFTGTAPVINSAIAPETSYSFVIIA DRSMFTNEISIVSYYGRSWYNAPLPNWMFFDSDELKFTGTAPVINSAIAPETSYSFVIIA ------------------------------------------------------------ DRSMFTNEGSIVSYYGRSLYNAPLPNWLFFDSSELKFTGTAPVINSAIAPETSYSFVIIA ------------------------------------------------------------ PKQMFVEESPVVAYYGLTRFHAPLPSWLFFDSSQLRFSGTPPVVNSNTAPEVPYSLTIIA ERDTFTDSDSIVAYYGLSEYHAPLPSWLFFDENNLKFSGTAPVVNSEIAPEMDYSFSLVA EKNLFKSDRPIIAYYGRSADRSSLPNWIYFDGDTLTFSGTVPYVTSENAPSIDYSFSFIA DRDTFTETSSSTSYYGRSLYHAPLPNWVFFDENNLKFSGTAPVVNSEIAPESSFSFSLIA DSDIFKSSRPIVAYYGRSSDRSSLPNWIDFNSDDLSFSGTVPYVASENAPSFKYGFSFIA EKKLFESDRPIIAYYGRSADRSSLPNWIYFDGDALTFSGTVPYVTSENAPSIDYSFSFIA PKID-----DSVAYYGRSSDRTSLPNWVKFSGN--TFSGTVPYATLENSPSQAFNLNYIA NKNLFESDRPIIAYYGRSVDRSSLPNWLSFDGDDLTFTGTVPYVTSENAPSFEYGFTFIA SKDDFQAEMPIIAYYGRSSDRTSLPNWVSFDADSLTFSGTVPRVTSDIAPSIEYGFSFIA EKSVFESKRPIVAYYGRSADRSSLPNWIDFDSDSLTFSGIVPHVVSDIAPSFEYGFSFIG DSSVFEATRSIVAYYGRSSDRGSLPNWINFDSNTLTFSGTVPYVTSENAPSMEYGFSFIA DRSTFTDEQEIVAYYGRSQYNAPLPSWLFFDPNTLKFSGTAPVANSQIAPQIGYEFTLIA DKDTFVTDRDIEGYYGIMRNHTPLPIWMSFSPGDTTFAGQSPAINSQIAPAQAFAVEFVA TDIDGYAGIEVPFELVIGAHTLTTSQNTLVINVTETGNISYKVPLNYVYYDDAPITTNNL TDIDGFSAASINFQIVVGAHRLTTSENTLIINVTDSGSFSYPVPLDYVFLNDEVISKDDL TDIEGFSAVEVTFELVIGAHQLTTSQNSLIINVTDTGNVSYNLPLSYVYLDDDPIAYDKV TDIEGYSGIEVPFNLIVGAHQLTTSQNSMIINVTDSGDFNYDIPLNYVFLDNNEITMGNL TDIEGFSAVEVEFELVIGAHQLTTSQNSLIINVTDTGNVSYDLPLNYVYLDDDPISSDKL TDIEGFSADEVEFELVIGAHQLTTSQNSLIINVTDTGNVSYELPINYVYFNNNPITSDKL ------------------------------------------------------------ TDIEGFSAVEVEFELVIGAHQLTTSQNSLIINVTDTGNVSYDLPLNYVYLDDDPITSDKL ------------------------------------------------------------ TDFEGFTGVEVPFGVVVSAQKLTTTTSPLVINVTDQGVLDYELPLNYILLNGKPITEAEL TDVAGYSGVEVNFRLVMGAHQLTTSENTMLINVTDSGSFSYDIPLNYVYLDGQEISNSDI SDYYGFAGAEGKFKIVVGGHQLSTSNETNIVNGTIGSKIDESPILSDVFLDGQPISKENI TDLKGYTGAEVSFDLVIGAHQFTTSQNTLAVNVSSSGDFQYSLPLSYVYLDNEPVSLSNI SDYYGFAGAEGIFRLVVGGHQLSTSNETIKLNGTLESEIEVDPILSDVYLDGEAISTANI SDYYGFAGAEGKFKIIVGGHQLSTSNQTNIINGTIGSIIDEEPILSKVFLDGQTITKENI TDIAGYAAVVKTFEILVGGHQLSTDKEAIEIEGYKNEEVEEDVPLSHVFLDGAQIAKENI SDYYGYAGAQGDFKIIVGGHQLSTSNQTTTINGTVDTEFDEIPILSDVYLDGSVITRENI SDYYGYTGAEGIFKLVVGAHQLSTSNESLKINGTFGSDFDYSPILSSVYLDGNLITRDNI SDYVGFAGAEGIFKLIVGAHLLSTSNESIKVNGTLNHDFDILPIFSSVFLDGSLISAENI SDYKGYAGSEGIFKLVVGGHQLSTSNETIKLNGTLRSEIDEQPILSSVFLDGNKISRDNI TDIENYSAVEVPFSLVIGAHALTTSQNTLVVNITDTRSFSYDIPLNYIYLDGDEINTNNI SDYAGFSAVSQTFSLVVGAHQLTTEESSISLDAKRGNEVDGQLPLDKVILDGSPIG-DQL GSLNLVNNPAWIRLNNDT--IEGTVPQDIKSGNFSVVIYDINGDVIYLNFEVEATTKLFA GDIKLVDTPDWISI-SDNYTLEGTLPSNESDYDFQLSIYDKYMDVVYLNFVIESTQNLFA GSIDLLDAPDWVSLDNTT--ISGSVPSDMLGANFSVSIYDTYGDVVYLNFEVVSTTDLFA STPTLVNAPDWVQL--NNFTLSGSLPSDTSSNNFSVAIYDIYDDVIYLNFDVVSTTNLFA GSINLLDAPDWVALDNAT--ISGSVPDELLGANFSVSIYDTYGDVIYFNFEVVSTTDLFA GSINLLDAPDWDSMDNDT--ISCSVPSNLLADNFSVSIYDIFGDVVYLNFEVVSTTDLFA ------------------------------------------------------------ GSINLLDAPDWVALDNAT--ISGSVPDELLGANFSVSIYDTYGDVIYLNFEVVSTTNLFA ------------------------------------------------------------ STITLHDNPKWVKNSGSKLYGKLSEPAT---ANFTVSVKDIYGNTIYLTITIESTERLFT SSIELFNAPSWVTLDNQT--LSGNLPNSSVTGNFSVAIHDVHQDVVYLNFAVESTQKLFA SDIYDQDLPNYATFDKNNFTITGTFPNTSTTDNFTIVVKDIYGNSVELPYSFDVVNSIFT SSITLLDAPEWASISNTT--LSGTLPEDISGKNLTVAINDIYGDSIYLNFLVESTSKLFA SNVYAEDLPDYVTFNEDNFTLTGIFPDKSTFDNFTIIVEDKYGNSVDLPYLIDAIGSVFT SDIYSQNLPNYAIFDKNNFTITGNFPNTSSSDNFTIVVKDIYGNSVELSYSFDIIDSIFT SSVIGDDLPDYLELDTSDYTISGTLPNDESDTTFNVQIEDIYGNKVQIPYSVRISK---- SDVTVDGLPDYIQFNNDDYTLTGTFPNSTTNDSFTVVVQDIYGNSVELPYIFDVIDSIFT SNVHSDDLPSYIHFDDYHYSLTGTFPNKSTFDNFTISVEDVYGNEVQLPYSFESIGSVFT SSVDSTDLPSWIHLDTDHYTLTGNFPGDATFDNFTINVKDVFQNEVELPYSFNAIGSVFT STVSGEDLPDYLHFNSDNYTITGEFPEKSTFDNFTIMVYDVYGNSVELPYSIDAIGSVFT SRIALNDSPSWVKIDN--YTVEGTVPADDLSETFSLAIYDIFGDVIYLNFEIMSTTNLFA GSIQLKDG--WLKVDNNG-KLSGTPDDNATSGPVSATVYDKYGDAVAIVINVNVVTSIF- TSSLPNLNATRGEWFYYNFLPSQFTDFDTNVSVKGDTDHDWLNFVSSNLTLMGRVPQNFQ ISSFPSVNVTRGEWFQYALLPSQFTSFDTTVSANYSSQANWLRFQSSNLTFYGEVPDDFD INSLPNVNATRGEWFSYYFLPSQFTDYSTIISLESSQDHDWLNFHSSNLTLMGKVPNNLE VSSLPNINATRNEWFQYSFLPSQFTDPSTNISVFSSQSHDWLSFHSSNLTLIGQVPNDFD ISSLPNINATRGEWFSYYFLPSQFTDYVTNVSLESSQDHDWVKFQSSNLTLAGEVPKNFD ISSLPNINATRGEWFTYYFLPSQFTNYVTNVSLESSQNHDWLNFHSANLTLAGQVPKDFD ------------------------------------------------------------ ISSLPNINATRGEWFTYYFLPSQFTDYVTNVSLESSQNHDWLKFQSSNLTLAGDVPENFD ------------------------------------------------------------ VSELPVVMATRNSWFQYDLSPSVFLRSSFDVSVSYS-GADWLHFTKSNLTFQGVVPKDFS ISSLSNVNATRGEWFQYFLLPSQFTNYDTDVSIDSSDSHDWLSFKSSNLTLSGKVPRDFN IDSLKDVNATRGQYFQYQILKSYFTDAETKVTVDSGTNSDWLQYHDSNMTLSGITPKNFN VSSLPNANATQGEWFQYSLLPSQFTDYDTDVSVSNSTSSSWLSYHESNLTLMGEVPKSFK VKDLKDVNATKGEYFSYELLKSLFTDYNTKISVDYDAD--WLTYHKDNRTLSGKAPNNLD IDSLKDVNATKGQYFQYQILKSYFTDVNTKVNVNSGSNSDWLQYHDSNMTLSGITPKNFN -------------------------------------ETSLSSIYESSYTASSSSSSSTS TDSIKDVNATKGEYFQYQILDSLFTNIDTQVTVDYDSD--WLDYHESNMTFTGETPKSFD VDKIPDVNATRGDYFQYQLMRSFFTDFNTKISVSIPGNSTWLTFHQSNYTLLGTVPSKFE LSTLPNVNATRGQFFEYHLMNSYFTDFNTDVSVKFDSSNSWLTFHEDNNTFTGQVPKDLQ VKDLPDVNATRGQFFSYQLMKSIFTDYNTKVSVALD-NASWLTYHQDNMTFNGITPKKFD VNSLPNINATRGEWFQYNFLPSQFTEYSTNVTVENTEDFTWLSFHASNLTLYGNVPEDFS ATQIPDVNATQGGWFSFTIPQFRLSRKRATLSASPASAGDFIHFNPSNMTFSGEIPDDFE RLTIDLVAQKNSLSQQLPFTIIGMDKTTNHTNITTSANATNSSTLYSHSTKTAAIACGVA DLSIDIVASLGSKMDSLVLKMVGIDAKNSTKTQTSSSASHTATSKSTKSTNIVAIVCGVV KLSLALMANQSSHSQELDFNIIGMDSKTTHSNHSSNATSTRSSHSSTHSKKTVAIVCGVV YLSIGLRAQEKSLSEELSFKIIGMDSKSNHSKNHTSSLNVTSTYHHSNNSKTVAIACGVA KLSLGLKANQGSQSQELYFNIIGMDSKITHSNHSANATSTRSSHHSTHNKKAVAIACGVA KLSLGLKANQGTQSQELDFNIIGMDSKTNHSNHSANATSTRSSRRSTNNKRVVAIACGIA ------------------------------------------------------------ KLSLGLKANQGSQSQELYFNIIGMDSKVTHSNHSANATSTRSSHRSTHSKKAVAIACGVA ------------------------------------------------------------ ELSVEITAKGATKSETLPLKFSGRSKVQPSTSTTRSSSTSSPSETSTDLKRLVAIVCGIV SLSVGVVAKEKANSQKLSFKIIGVNGRNHHNSTNTTTTTSSATSSTAKNNKTVAIVCGVV SLKVEINAESNSDKESKSFQIKGVDKKIVSSSSSSSSTSSSSSTASANKNKALAIGLGVG SMTVDVKAKQKSKTQQLSFKLAGVPSKRKTSSSSSSSSTSSATKTSTSNSKTVAIACGVA KVKVKVAASSDYDSETKSFNIDGISKKKSSSSSSRSSSSRASSSATSVDHKALAIGLGVG NLKVEIDAESNSDKESRSFQIKGVDKKIVSSTSSSSLSLSTSSSSSSNKNKALAIGLGVG SLSRSLTTSSASASATS---------SSSSTAETSSAAAAAATIHNKSSNNNLAIGLGVG KLNVKINAESNSQTESRSFQIKGVDRDETTSSSSSSSSSTTTSSSSTTNTKALAIGLGVG SAIVKVEASSDFDSESRSFQIKGVDKSLHKSSSSSSYSSATATSSSSNNHKKLVLGLAIG KINVDVSASSDYDLEDKSFDIVGIDSKTSSTSSSSSATATSSSSSSPTNHKALAIGLGVG SLTAKITAESDYDEETKSLNINGVDKTKTSSSSSSSATSSSSSSPTPINRKALAIGLGVG SVSLNLVAEQNSRIDKLGFRILGTNPNITTSRNSSSTTRSSSTLSSLSSKKAVAIGCGVG GADVTVTAVDGDKSDTMTFHINGTKKSDTTSSASSSSASSTSTSSGSSNTTAVAVGCGVG IPVAVIILVVLAFLFY-RSKKKTE-PKDEEKTPNISPP-------------NPYNPANNP IPIVVLLILLIIFLL--WRRRRNEKKENDKEKMAISGP---------------DPKNPAN IPLGVILIAVILFLVF-WRRRKES-SDDEKSPNAISGP------------DLDNAANKPN IPVGVIIIIAILLFMF-WKRKQNNQVPDEEMVRNISKP-------------DVNNPANDP IPLGVILVALICFLIF-WRRRREN-PDDENLPHAISGP------------DLNNPANKPN IPLGVIIIAVICFLVF-WRRRKES-SDDEKSPHGISGP------------DLDNPANKPN ------------------------------------------------------------ IPLGVIFVAIICFLIF-WRRRKEN-PDDEKLPHGISGP------------DLNNPANNPN ------------------------------------------------------------ IPLAVILAVLLLLFLL-WRRRQSKAKDPEYSTKHISSP-----------PANRPNMFASK IPVVLIIVLVLLLLLF-WRKKRSAAAKEKQDEEKFSGA-DGVQMNGTTN-----NKNPFV IPVFLILVAALILLCCCLKRRKNKYFNEFKQPRKPMPPNGIAGAGAGAGTSSNESIKDES IPLVVLLAALILFLLL-WRRRKNKATEDDESSPRIGKP----------------QLGNPA IPLFLIALAALILLFCCLKRRKNKKEDDFDQEKATTGA-----------ATGAAAGVAAG IPVFLILVAALILLCCCFKRRKNKTDDNDEYPNDSRKPIPTNGVATGVATSSNESIKDES LGVGIPLLALLILGLCCCRRRKNK--DKTASASTAAGA-----------GAGAAAAAADM IPAFLILLTALILLCCCIKRRKNKNNSNNDDHEKEFIPVSPTGIPAINSLEHINRSHSSS VPIFVVLVAVLLIFFCCFARKRKG--SSDSEKSVENEPLNGPGFGV---THNLDDHHETA IPAFLLLVAALILFCCCIKRRKERQDPRKDMEKDAAVPLTGPGFGNTYDDSQKGRKLAAA IPAFLILLAALIFVVCCRRRRNTN-KDSDNPEADMSNT---------------------- VPVGLIVICIIIFLF--WRKSHKKNVEDTEKGQDPKGP--------------GNGPVTGS IPIGLIA--LALLVFCCWRRKRHNSNDDDFEKANISHP--IPFDDGHQDLTPSKSPNGGP NKAATSLENPFEDDSDADSA---KRRLDMLNALKLDDAS-------TTDSDTSTMDEKRS DPNACGDVNPFSDENTLDSGSTEAKRLATLNAMKLDDVS--------NSSTMTSLDEKV- QGNATSLDNPFDDDASSYDDTSIARRLAALNTLKLDNHS-------TSESDISSIDEKRD KQAVTSLQNPFDDDSQN---SQLAKRLTALNEMKLDQSS-------LTDSENSTIDDEKN QENATPLNNPFDDDASSYDDTSIARRLAALNTLKLDNHS-------ATESDISSVDEKRD QENATPLNNPFDDDASSYDDTSIARRLAALNTLKLDNSS-------MSESDISSMDEKRN ------------------------------------------------------------ QENATPLNNPFDDDASSYDDTSIARRLAALNTLKLDNHS-------TSESDISSMDEKRD ------------------------------------------------------------ SRRKEANANPFADPPASQSE---AKKMAALNALHFDEHS-----------SDTSLVNEKD SGAVVGAASPFDDDGSISD-TSTAKRLGAINAMKLDENA-------SSSDETTFDDDEKR TMNVFKLEHNYSKSSSSLTQENTPIVKSWRANTESDSKLISNGSLATVNTSVRLIDDYSV NHPNAYGVSPFGDENSIGN-SSTARRLGALNAITLDNEV-------ASASDGSTMDEKAE SGSPELTGPGFGTTVDLDDRDENAKQLAALNVLKLDEKDKLASDAHSTSSSVTHVESEY- TMNVLKLEHNYSKSSSSLTQENTPIVKSWRANTESDNKLISNGSLATVNTLVRLIDDYSA EKGTYDDASPGSNYTATSTSFAPLTQLTPASVSQL---------------NLMKLEKSAA SLTQVESSSADSFYDANE--NAPIVKS-WRANIESDNKLASDASLSTVNTSIRLVDDYSA HQLGALHALKIDDDADSM--LSSVTHVDSDQDSHYYDAAPMKSWRAMDDSDLTDIKKQFL NARKLDNTKPYDYDDDIHSTSSSITHVENGSAARYVDAIPVKSWRARDNSSLSTVNTEQL ----------------------------TATGFAANEKGEDTARQAGVLGALKSTNMESN QDDSDATIDPFS--------DVNAKRMDVLNAIKLDNIS------SSSESDNFTLDEKKS GGPGIAAPIMMDKGKEVDEDWDTPKRLSAMNFFKVDQYDDASMYSSERTHVDREIEERPD -----NKSDIFYDTNNTNSRDLLLEHKDTNSTFFE--RSSSVYVDSIPAHKKSWRYTLAS -----SADSVYQDAEMANSRDMLLQRDDESSVFD---RSSSVYFQNAPSQRKSWRFSK-- SS---SVMDMYDDAFQSQSKEELLAKSPAQPVVSPFFRSSSVYMDSEPAVNKSWRYTGDL -----DTNGLYADPFHSQSDELLLKDESQNAIFNPTRPTSSFYMDSQPATMKSWKNNSFN SL---SGMNTYNDQFQSQSKEELLAKPPVQPPESPFFRSSSVYMDSEPAVNKSWRYTGNL SL---SGMNMYTDEFQSQSKEELLVKPPAQSAESPFFRSSSVYMDSEPAVIKSWRYTGDL ------------------------------------------------------------ SS---SGMNTYNDQFQSQSKEELLAKPPAQSPGSPFFRSSSVYMDSEPAVSKSWRYTGDL ------------------------------------------------------------ EFEEKDDSVLSVDAMD-RIAAAEHGLPRSDSVYITTDKSASVYYNSEPSQRRSWRYSAHM NS---LSSDLYRDAMQTHSTDMLLHNNEADDYYDPKLRSSSVYFNSEPTNRKSWRFSTNP RNSETSSKFLSSNSLNALRRESLSNNNSNNSTNFQRLGELNFNNNNNPKSNRSSSSEKYM CGSLSSSSDSYHDAALAGSTDALVPRDEHDQYFD---HTSSVYLNSEPTNRKSWRFSKRG -----SDDSRYFDA---SEKPLKSWRANDKSDIAKG--------GMIGAAGA---GTGAV RNSETSSKFLSNNSLNA-----LLRRESSSNNNFQRLDSNGNIVGELNNHSKSSLSEKYM AND--SDLSLSSLTTHVNDEDQQLQQQQQQKQQ----KHLDSQGQQQQPVVTSWRADAKT RNSESSSKFVSNNSLNA-----LLRRESLSSNF----DSSGNIVDNLNQNNNNNNNNHSN MEQ--KHASLFSSDT--VNTSKLFSVRLVDDNSRRESENRISFNSNSSGNFQRLDSDGNI FSVRLDDQSARNSQQSSFVARQLLSSTSLHEVMRRDSDSDGNIVDSATSSNAPWKTVPKS ST---SSSITHVDSH----------------------SDEDRFYDATEKPLKSWRADDSD HHSIGSSGNVYFDASNSPSTEMLLGKPDNYSSDDVRFRTSSLYLNSEPASRKSWRFNPDR NVPEMVDSDYYTQPHG-IGAHTGAGLSEG--------AGAAAAAGVQQPAQTVQPRKSWR ARSSHQPGN--IRDSYSSLNTVSTAELMNTTISDEADIPKDPRKSTLGLRDSVFLDMGSK --NKIQPDDRTMRQSYASLNTVSTQELLNSELKNDSTLPHDPRKSSLGLRDSVFWNKDTN PAVSDS-----VRDSYGSQQTVDTEKLFDLDVPPQQKQNSALRDVTMSSLDPWNGDINDS PSKY-------NRDSSMSLNTVTTADLMNTEIKEDDIIPKDPRKSSLGLRDSVFWNKSQ- SPVSDI-----VRDSYGSQKTVDTEKLFDLEAPEKEK--RTSRDVTMSSLDPWN------ PAVSDA-----VRDSYGSQQTVDTEKLFDLEAPQRQM--RTSRDATMSSLDPWNTDVNAS ------------------------------------------------------------ PRVSDS-----VRDSYGSQKTVDTENLFDLEAPQKQK--RTSRDVTMSSLDPWN------ ------------------------------------------------------------ SKRNSAQRAAPRRESHGSLKTVSTAELLNTEVTTHSNIPHDPSKSTLGPRDSVF------ SNGN-------VRESYNSLNTVSTAELLNTEIADNKIIPKDPKKSSLGLRDSVF------ TQLSSPLPPPSLPQSQANLHIVPEEKSRDLSHTGKDETTQFNDNRSKVSDDEFNSSSRVK ISSVGDSPERNMRESYNSLNTVSTAELFNTQIARDRTLPKDPKKSSLGLRDSVFMGHPSA AGLALLSKDNNVRQSDASMSTVNTEQLFSVRLVDDNSYRGSGQFLSNGSLNALLRREESG TQLSSPLPPSSLPQLQANLDIVPEEKSRDLTQTGKDETTQFNDNRSIDEYDNSIATRQQY DNKEVTSQAQDLRFSTATTSTVNTDNLFTVRLVDDNNGDNSARLSN-------------- RSSQSEKYLPQVSSSNLDIVPEENSRELKQTGKDETSGTNDNTSSEDGEFDEPEPT---- VEHGSSSPVKS--------MTTRPTSLGNIKEEGHDEHTGDSFYSTANESSSYNLMAKFL GSILAILPEENSREYTNSVRNATDTSTVYLSADHSTNSNNSNSHTSRHDFSESS------ DANGGTAAGNAYRASNGSMSTVNTEQLFSVRLIDDNSYRPAGQFMSNGSLNALLNRSDSG TINGNNRE---IRDSYVSLNTVSTDEFLNTELSNEDEIEKDPRKSALGLRDSMFNNRES- QTIDSTRRWQD-RQSMASLATVSTDELFSVRLVDDDEEQHHIGTNSTGQHSGHSGHSAQH GNSFSSQMLSESSGHSSQNIPHDTSMRTFER---------PILEEEASD----------K SSSPLKPVSENDITESAARTD--------------------------------------S NTKTPTPKNRTTNGNPHLPDSRSVIN---------------------------------G RNSDSSKSNTKQALEPVAEFSDNKND---------------------------------N SNISPSPVRKSVTPSPYNVTKHRN----------------RHLQNIQDSQSGKN-----G NSITPSPQNATKNDN-------------------------LHLPTLRNSQYGTK-----G ------------------------------------------------------------ SNISPSPVRNSVTPSPHNVTKHRN----------------PHLQNIQDSRCGTN-----G ------------------------------------------------------------ LSGTGKPISDASTGKYTLPPLTE------------------------------------T WDTKGNPSLTKSGSIGQMKNDEHQTE---------------------------------G QQQHQHPLSRENSFSNHYDFDNRLPSPNYALTNSSTMVSPDTFLLDESTPINNNHITNTT GPQHDSSILRKNEAMNKVALPNV------------------------------------T IVGTANGLLRGVSAHSRTPSSDLDILVEENSDHSNDTNDTNDILGDDTASLNSRFQESRT QQQPQHPLSRENSFSNHYDFDNRLPSPNYALAKSNKYGGTSDTFLLDESTPVNNHHIIST QVYSRQSGNTSKTASQLMLVPE-------------------------------------- PVDDRLPSPNYALDSSKLGKYDSPSSEK------------FLLNGDDNEKTPINNNG--G NGGSRSPSNSDIEVQNHEDSSED-----------------FQAIKKSIGNLDWKNSK--D ISNLLSKFNESPSGSERDLSQYQHEDSAYLDFKAVKTSNGFQWLSDRTDRSSEDNTDLMT GNIITSPNQSPKKKISRSPSENLH-------VLMEESGSRKQTLEPQDKPSGASSFKFLD VDSKQRHSSRRYSSKYGVLPA--------------------------------------L FVSNSRPNSSLKINSNLASVTEESPNLHKHLPNIEAANEYNTFTNTPPPPIPAVSTN--R HTPGTVSSSS----------TDDFVPVKNGTS-YEW------VSKNSPNRKPSVKRFVDI QSPHSSMS------------SDGLIPMKQQDGQYKW------VTNDQPVRKKSTKRVGSV RTPTSMSTSS----------SDDFVPVKDGKT-FCW------VHSTEPDRRPSKKRLVDF NTPTSMSTSS----------SDDFLPVKNGDN-FDW------VRTNDVNRKPSKKRLVNF ITPTTMSTSS----------SDDFVPVKDGEN-FCW------VHSMEPDRRPSKKRLVDF ITPTTVSTSS----------SDDFVPVKDGEN-FCW------VHSTEPDRRPSKKRLVDF ------------------------------------------------------------ VTPTTMSTSS----------SDDFVPVKDGEN-FCW------VHSMEPDRRPSKKRLVDF ------------------------------------------------------------ KYKSGLSADSNESKRASDSSGSDFIPVKQGDT-YQFRSTDSRFGKTAPMRKQSTKRLVNL ALPVLRESPSKLDHESYTSHSDTFIPVKQGNG-YRWDKQNIQAPAPPPVRKRSTKRLVNL TAPTTTTTNSNPN-NNNNNQNLSAISLGSINSDKFFANKNSPSSTPNSLNIGKSAKLVDF EHPQVQASNNSQLSESS---SDDFIPVKQGEI-YKW-VERQDGESLEPTRKKSLKRLVSL SGPTSYQQLVNQNNEHGDFA-DEFKATRNPNSEIKWNLSAISLGRSSSENPRISAKLVDF TAPTTTTTTTTNNNNNNKDGNSSAISLGSINSDKFFHHSNNNNNNNNGHTPPPNAKLVDF ------------------------------------------------------ANLVEF PTMKHQNLSAISLGSLTSDKLFFVDNSSSSNNTTNSNNMNTKPTPPNSMNIGKSAKLVDF ALLTSPNTESFFLDS-----EDTPKNNHSLATSNLYNASRTSILSDFSDSNILEAKLVNF ASNFNLSHDDLAIATKTLPMNLSTISIESGNSDQMLNHDGSPQIPKRSRSRTSKAKLVNF SEPNSSNPSASSSDQQISQSVGDFKATRHQDGTFQWPVKARPVSQHSNGSRISIAKLVDF DEAFSHSEYTSEGTMSTSSS-DQFIPIKSGER-YKW------VTKNEPDRKPSKKKYIDL PSPSSLRSQLEPPNQQFDFEPEVEWKGDSSNLVPGWSDDDRYHRYHDSVSEPHYPKLVNF SNSSNIN----------VSQAGNFEGHSPEHIKQDAEGTGVLMGSVEMGEKRSNEEEL-- REQAGVN----------VSNVNNFTGESPERMHADDLDDGLVYEQDDDVVSDGELVELDK SNKSNVN----------IGQVKDIQGRVPEMLNPDDLEDGLVYDSEQEVGIEGNGNNGLQ SNKGEVD----------VGEAQQVDGHIPEEINPDDLDDGLLYEVDAEPIEETEEDQLND SNKSNVN----------VGQVKDIHGRIPEMLNPDDLDDGLAYDDAKDGSPPTKKVQKRS SNKSNVD----------IGQVKDIHGRIPEMLNPDDLDDGLAYDVDADDNVNSSLSPGLK --------------------------------NPDDLNDGLAYDLDAQIGSSSSQTSQKR SNKSNVN----------VGQVKDIHGRIPEMLNPDDLDDGLAYDDAKVDSPSSNVLQKRS ------------------------------------------------------------ PNRGGVN-----------VSDASLIGQEPERDNADDLDDGLAYEIDESVNSDVEEIENID PNKSGVN----------VGDADMIQGQEPERT---------------------------- TRKGSLRESAYEPDYIYTGQSASIQIDDSD--VADDLDDGLEYDDNEDAGFVNDGGEEGI PNKSGVGICNADIEGQEPEMDTSLHSNDI---LGDDLDDGLEYEESEEEVELENESETVK TRKSSMRESAHEPNIDLEGETAQIHYDDDSV-VGDDLDDGLEYNSGEEINPDSELEDDNN TRKGSLRESAYEPDYVYTGQSASIQIDDSD--VADDLDDGLEYDDTEDVGFVNGSWDEGI TRRGSLRDSSFEPDHVHMEERASFHLNDDSV-EADDLDDGLAYEDENDNGIMEGEEHEVE TRKGSLRESAYEPDYVYKGESASIQDDDSD--IADDLDDGLEYDDTEESTFPVTEANDNS TRKASLKESAHQSNLNHPGETAQIHDGDSE--AGDDLEDGLEYYGPEGGSEAFDSETEIE TRKGSLRESSYEPDIKFHEESAQVHSNDSD--IGDDLGDGLDYDEPESGARNEISGDEYV TRKGSLRESAYEPDYQYQEESAQIQNDSD---GGDDLDDGLEYNEDEGTAVNTEEIKLPL -----------DGNNIDIQRGLEIEGHSPEKLNADDLDDGLVYDSAGEITEEVSEDKNIE TNSGRASSSDSPMSSSRDMENSQSVSAELAFIASDELDDGLAYTSDTEAADLAPLEDEEE ------------SKRQKKLKHGKLAQKRREQAAYEEERKLPMQGAEAISEHFATVIRAQN DNDSNTADEVSESKRQKKLANSSLHQKKLERMAYEKAENLPKASVDKIIEYLATSIRDKN KRPIQDDHEDEKKRQKKLQKKSKFIEKKKEESQYIVSKSIPTSSPEKIIEYLTALIREKN RKRPLENEGVATSKRQKKLKNSKLHQKKKEQVEYQINKSIPKASSEAIVEYLATLIREKN IEQDDDDVDDIDKRQKKLQKKSKLIEKKKEESQYIVSKALPASSPEKIIEYLTTLIREKN KRPMEDDDNDADKRQKKLQKKSKLIEKKKEESRYTVSKSIPTSSPEKVMEYLTTLIREKN PLEDDVDETDGKKRQKKLQKKSKLIEKKKEESQYTVSKAIPTSSPEKVVDYLTTLIREKN IEEDDGDVDYTDKRQKKLQKKSKLIEKRKEESQYIVSKAIPASSPEKITEYLTTLIREKN ------------------------------------------------------------ VGHEATADASVPSKRQKKLSKSKSHLKKMEKMEFEKEKELPQKSPEAVVDYLSKLIREKN ------------------------------------------------------------ SNDETEINDNTTLKRRNSNTNNSLKEKKRLKMEMDIEKNLSLENPEIIAEFINNKIRRKN RSLPEDDSEVVPSKRQKKLAKSKLHQKKLEKLKYEKEKQLPKSSPERITEYLATLIREKN ASDEESKKAKTENGKKRKAKTSKLQEKKKVKMEMDIAKNLSKSSTDVIADFINNKISQKN TKDETETNDNTTLKRRNSNTSNTLKEKKRLKMEIDIEKNLSLENPEIIAEFINNKIRRKN VNGGDNDDQLINDSKKRKRDDSSLKEKKKIKMEMDTEKNISLENADVIAEFINSRIRRKH NDEKEDEEEEKMRKRKNSTTVNSFKDKKRMKMELDIEKNLSNDNTEVIAEYINNKIRRKN RGESKEESVEAEKNPKKRKANSKLHEKKKLKMSMDISKNLSKSAPEAIADYINDSIRRKN NVNEDDFQEDIKEGKKRKAKSTKLQEKKRLKMEMDTDKNLSKSSTETIVDYINTKIRQKN GSADDNDEADEPSGNKRKHKSSALKEKKRIKMETDMQKNLSKVSPEIIADFVNSKISQKN NTIDEATNTSEKSKRQKKLRKSKVHEKRKEQAIYLEEKSIPKGTNEEISDYFTTLIREKN EIVKTKKRVLPEQKKKKKTKNESAVEKKKEKAENYSQVELALKDSAMIADFIAAKVRAKN PDLSAIELDEMYLKKSEFLGTEAFDGVRNLHEFPGFMARFSRAPRAIVLSMSNIRVADVY PDLSALELDELYFKKQDFLSTEKYEKDRSLNNFQDFIHTFSKSPRSIILSQSNIRVADVY PDLSALELEELYFKKKDFLSTEKFDTERKLTDFSAFMQKFSVAPKKIVFSMSNIRVADVY PDLSALELNELYFKKTDFISTEKFNVDRNLVNFPQFLLQFSKAPKSVILSMSNIRVADVY PDLSVLELEELYFKRNDFLSTEKFDAERRLSNFPAFIQKFSVAPKKIVFSMSNIRVADVY PDLSALEX---------------------------------------------------- PDLSVLELEELYFKKNDFLSTEKFDVERKLTNFPAFIQKFSVAPKKIVFSMSNIRVADVY PELSALELEELYFKKNDFLSTEKFDAERRLSNFPAFIQKFSVAPKKIVFSMSNIRVADVY ------------------------------------------------------------ PDMSVLELEELYFKKSDFISTESFTQERTLANFPTFAKMFNKAPRAIVLSTSNIRVADVF ------------------------------------------------------------ PNLSALELTELYFNKSEIRSTSDFKDTRNLDNLSKYINSVKKDKKKAIVSMSAIRACDIH PDLSGLELEELYFKKSDFLSTERYAKDRVLDNLQDFVNSFSKSPRAIVLSTSNIRVADVF PNLSTLELSELYFNKTNFRSTSEFDEERSLDNLTKFILGDKKNKKNAIVSMSALRACDIH PNLSALELTELYFNKSEIRSTSDFKDTRNLDNLSKYINSAKKDKKKAIVSMSAIRACDIH ASLSALELSELFFSKSDIRTTHEFKEPRTLDNLGSYINQQGKQSKQAIVSMSAIRACDVH PNLSALELTELYFNKNEIRSTSDFKETRNLDNLSKYINLMNKKDKKAVVSMSAIRACDIH PDLSALELAELYFKKTDFRSTADFAHPRTLENLSKFILDPSSTPGKAILSMSAIRACDVH SDLSALELGELYFNKSDIRSTSDFNVERNLDNLSKFIVAGSKKEKKAIISMSAIRACDIH PDLSSLELSELYFTKTDFRSTSDFTDERTLNNLGDFILSSKKSKKSAVLSMSALRACDVH PDLSALELEDIYLKKTDFISTAKFADKRNLTNFPEFMSQFSKSPKAIIFSMSNIRVADVH PDLSNIEINELTISEKQIKETASWRTPRVDDKLARFLEKNACDKWTIVLSISAIRVCDVH RSLGGSSQCVKLFAKNKLHEDVATVESVLIKYFVATPTRLEKLLESTFFEGKDKLDIILD RSVNGHQTAVKLFSKNKLKDDITKVEELLVKYFISTPTRIQKIIESTFFQGKEKLDIFID RSLNGGKNCVKLFSKSKLKDDIATVERLLSFYFIATPTRMQKIIEETLFQGKEKLDIILD RSVEGNNNAIKLFAKNKLKDDLQSVEDILLKYFISTPTRMKSLLESTFFQGKDKLDIILD RSLNGGKNCVKLFSKSKLKDDIATVERLLSLYFIATPTRMQKIIEATLFQGKEKLDIILD ------------------------------------------------------------ RSLNGGKNCVKLFSKNKLKDDILTLDRLLSLYFIATPTRMQKLIEETLFQGKEKLDIILD RSLNGGKNCVKLFSKSKLKDDIATVERLLTLYFIVTPTRMQKIIEATLFQGKEKLDIILD ------------------------------------------------------------ RSLGGSSNAVKLFSKNKLKDDLARLDQILVQYFLSTPGRMAKIIEESLFSGKEKLDIIVD ------------------------------------------------------------ RATKDVGSSLKLINKNKLHIDLKLVESTRSRVLCCTPGRLSKVLNSEGLSKDEIKIVIID RGLGGSKHAVKLFSKNKLKEDVARVDQLLIKYFISTPGRMSKIVDETLFEGKEKLDIFLD RATRESGSSLKLINKNKLDVDLKLVKTTRSRILCCTPGRLLKVLNSEELNKDEIKIIIVD RATKDVGSSIKLINKNKLHVDLKLVKSTRSRVLCCTPGRLSKVLNSEGLSKDEIKIVIID RATKDNGGSLKLINKNKLAVDLKLVGSTRSRILCCTPGRLSKVLDAEKLAKEEVKIVLVD RATKDSGSSIKLINKNKLHVDLKLVKSTRSRVLCCTPGRLVKVLNSQELSKDEIKIVIVD RALREPGSSLKLINKNKLHVDLKLVASTWSRVLCCTPGRLLKVLNDETLKSDEIKIVLMD RATKEAGSSLKVINKNKIEVDLKLLKTTTSRVLCCTPGRLIKVLDNEVLKKEEIKIVVVD RATRDSGSSLKLINKNKLDVDLKLVKTTRSRVLCCTPGRLAKVLASEPLKKSEVKIIILD RSLNGNKTSVKLFAKNKLKEDIDMVANVLLKYFITTPTRMEKLLENTFYAGKDKLDIILD RNLK-KAGSIKFIKKNTIKNDTIAVEKTQASVGVATPGRLLRLLDSKVLTPKDIKAIVVE ASYLDSKKNSLLDSENTCKVLRTDKKSSVKVLLYQQDRLTMSMIGRRWYMHAGGLRRDPV ASYLDPKNNTIFTSDDSYKVLKEKNKSSVKILLFKIGLNLSTKFGVRNYLHVGGLKRDPV ASYLDPKDNTILSFENACQVLKTNKKSSVKILLYPVSALNCNFQSIRSYLHKGGLRRDPE ASYLDPKNNSLLSSDNTCEILKLEKKSSVKILLYTSMVHISRSQSIRYYLHSGGIKRDPA ASYLDPKDNTILSFENACQVLKTNKKSSVKILLYPVTALNCNLQSVRTYLHKGGLRRDPE ----------------------------------PVAALKCNLQSVRTYLHKGGLRRDPE ASYLDPKDNTILSFENAFQVLKTNKKSSVKVLLY-------------------------- ASYLDPKDNTILSFENACQVLKTNKKSSVKILLYPIAALNCNLQSVRTYLHKGGLRRDPE ------------------------------------------------------------ ASYLDPKTNSIFTSDDGCKLLKTREKSSVKILLFSKISIG-TRQSTRHYIVNGGL-KNPN ----------------------------------IFSVPVTKTSTIRYYLHTGGLKRDPN NSYLDTKKQNIWDIKETFEALKELTKNGSKLYLYLSSRITGFTIFTRSYLHKGGLKRDPE ASYLDPKMNTLFTSEDQFKVLKETKKSSVKVLLFGYPRILGAQSGSRAYLHSGGLKRDPS NSYLDQKQQNIWDIKETPEALSITKEGGSKIYLY--MRNSLRVNPTRNYLHKGGLKRDPE NSYLDTKKQNIWDIKETFEALKELTKSGSKLYLYLSSRITGYTIFARSYLHKGGLKRDPE NSYLDQKKQNIWDIKETVEVLKDLTKSGSKLYFYRMPTTISNKTFTRSYLHSGGLKRDPK NSYLDTKKQNIWDIKETFEALKELTKEGSKIYLYTKSSGITSAIFTRSYLHKGGLKRDPE NSYLDQKMQNIWDIKETNETLKHLTDAGCKVYLY--MKMPPARIFSRSYLHTGGIRRSPE NSYLDSKQQNIWDIKETTDALKSLTKNGSKVYLYMLSSSVC-KLSVRNYLHKGGLKRDPQ NSYLDKKLQNVWDIKETTEVLKELTLSGSKVYLYVISPIFRASCPARHYLHKGGLKRDPD ASYLDPKKNSLIASENTCKVLKKDNKSSVKILLYRTAGLKAILNPTRSYLHSGGLKRDPA STYLDSKKNSVWDLEETKRVLDE---SDAKVMLYNSTPTMFGRLFTRQYQQRRAILQGPV SYLKNPAGLVYTDVGASVRERMGFQEHGIELSDAAILQCLTHKSFAHGSRPYNEKLNLLG ESLKNPHGLHYDSLVSTVKQGLNLEKYGIDLPDDIITQCLTHKSFAQGIKPYNQKLSIIG SYLRNPSGVLFTEIQDKVRSILQLPKYGINLSNELILQCLTHKSFAHGSKPYNEKLSLLG SFLKNPNGLNYESLKDQIKSILRLNDFQIDLSNDIILQCMTHKSFAHGSRPYNEKLSLLG SYLRNPSGVLFTEVNDKVRSILQLPKYGINLSNELILQCLTHKSFAHGSKPYNEKLNLLG SYLKNPSGILFTEVQDEVRSILQLPKYGINLSNELILQCLTHKSFAHGSKPYNEKLSLLG ------------------------------------------------------------ SYLRNPSGVLFTEVQDKVRSILQLPKYGIDLSNELILQCLTHKSFAHGSKPYNEKLNLLG ------------------------------------------------------------ EDLKNPAGLHYNEVDAKFKQAFNLDKYGLQIPDDILLQCLTHKSFANSAKPYNEKLSLLG EYLKTSTGLSYNELQDKVRSSLNLSQYGINLSNDLILQCLTHKSFAHGSKPYNEKLSLVG AAFINPKGIKYGLNETNISHIKSFLGDKYNIPDEIALQVITHKSFGNGIKPYNEKLAAMG EYLKLPNGLSYGEVAERVRASLNLQDYDITLPNKLILQCFTHKSFAHGSKPYNEKLSALG EVFITNHGYKYGKTQENLKHIKGFLPEKYSISDDLALQVLTHKSFGNGIKPYNEKLSAMG AAFVNPKGIKYGLNETNINHIKSFLGDKYNIPDEIALQVITHKSFGNGIKPYNEKLAAMG EVFKNQKGVQYGANDQTLSLIKSFLGSKYQIPDDVALQIITHKSFGNGMKPYNIKLSVMG SVFVSPKGAKYGVNEENIVNIKNFLGEKYAIPDEVALQVITHKSFGNGIKPYNEKLHIMG EVLKSSSGHSYGASKENLAPVKNFLDAKYAIPDEMALQVLTHKSFANGIKPYNEKLSAMG EVFVTQGGAKYEQSETNLKHIKDFLTEKYSIDDDLALQVLTHKSFGNGIKPYNEKLSAMG EVFTTFTAHKYGENADNLRPIKQFLDDKYAISDELALQVLTHKSFGNGIKPYNEKLSAMG SFLVSPKGVKYDELNEKIDKILNLSKYDIKVPNDLLLQCFTHKSFAHGIKPYNEKLSLLG DVLAKDSTRPYGLSEDALKS--SLSDSVSGLEDSLLLQVLTHKSFAGGLPSHNEKLAFVG SQYLKLQAAMHSVGPEN--------SFGNLGTPVSKGLVSYQTAAEYVIAKNLEPLVFWK GHFVKYQACLHSLGPVSRQLSQSVLNFGMLGKGSSKMLISKQSTAEFLQRRNLDKLVFWN SQFLKLQTSIHSLRDSPTETRENGLQFSNLGTKIAKELTSKKTASAFIKSHNLSPFIFWK SQFIKFRASVHSILHESSIKP----DFSQLGSIKSRTLVSRETSAQFIISNKLKGFVFWK AQFLKLQTCIHSLKGSPAESCENGLQFSNLGTKFAKELTSKNTACTFVKLHNLDPFIFWK AQFLKLQTSIHSLKDPPTEARENGLQFSNLGTKFAKELTSKNTACAFIKSHNLGPFIFWK ------------------------------------------------------------ AQFLKLQTCIHSLKGSPVESRENGLQFSNLGTKFAKELTSKNTACAFIKSHNLSPFIFWK ------------------------------------------------------------ GQLLKWYASALTVQPGAQQKPVNGLNVANLGHEPYTLWTDSKVISEHMRTRDVDDLIFWN SQFLKYYTSVYSLRKELLSQVNDSINFTNLGTQASKLLISKKSTSDFIKHNHLDTRIFGK SKLLSLYFAKYVTNPCKHDNGVEGKNLDVLGSPMSRELPSLKTAAIFAKSNNINEIMFWH SQFLKYHASVHTVKGREAAVKEGILNFAKLGSLESKKLIDKHTTAQLVRSRQLDTLIFWK AKILNLFCAKLVTDPTTNENAIDGKNLDSLGSPIAKELAGRMSLGLFAKTTNLNSIMFWK SKLLSLYFAKYVTNPCKHENGVEGKNLDVLGSPMSRELPSLKTAAIFAKLNNINEIMFWH SKLLKLYTAKYVIQSTTDKIKIEGKDLTKLGSLYSKELSGRDAAGYFAKVENLNKTMFWV SKLLSLFFVKHVTNKSTNTRAIEGKNLDVLGSPISKELVGLKTAGNFAKLNKLNDVMFWK AKVLNLFLAKHVVEPTTNELAVAGKNLDVLGSPMAKELSGRMALGVFAQSSKLNSVMFWK SKILNLYFAKFVVEPSQNELAINGKNLDVLGTPIAKELAGRLSLGIFARTNNLNLTMFWK SKVLNLYCAKYTTDPTTNENAIDGKNVDVLGSPMAKELAGRLALGLFAKSHKLNQVLFWK LQFLKLQAGIYSISSVNLSPVQAGLNFTNLGTQFSKLIISKYSTSKFIIEKNLDSLIFWK RKFFPVSVLSHNLKASSPVKALESLNFDLSG---------------FAAKNGLEKLVYWN VSDPNDGPIKGKSKVMSTVLNSFIGAILLQQGEKKASQFIVEDLLQSLLNITL------- KRDTKSHKYNGEYTVLQTVLNSVVGSVYLLHGQDKATEYVLHELFDSLTKISE------- MKDPKDGQINGETTIFASVLNAFIGAILSTNGSEKASKFIDGSLLHSLTNIAN------- MRDPGNSVRNGQSTVFSTVTTSLVGAILTTNGETKATKFVDELLLISLIDITN------- MRDPKDGHINGETTIFASVLNAFIGAILSTNGSEKAAKFIQGSLLHSLVNIAN------- MRDPKDGHINGETTIFASVLNAFIGAILSTNGSEKASKFIDGNLLHSLVNIAN------- ------------------------------------------------------------ MRDPKDGHINGETTIFASVLNAFIGAILSTNGSEKASEFIKGSLLHSLVSIAN------- ------------------------------------------------------------ KRDSATEKFNGLPKVRTTVLQALIGSSLTFNGEEKTAKFVLEELMNSLPSLAL------- KRVPKADQFIGEHTVFSSVVNAIVGGILMMNGPKKTAEFIEAELLVSLVKIAK------- TRNSLGFESSGELKVSGELLFSLVGAVNFYHGKNKAEQFITEKLVDQFEKISA------- KRDPKNENFNGENSVYSSVLNALLGGILITNGPEKTSHYIDSELLASLASIAN------- SYNHLSFESSGEMKVSAQMMYALVGAITFTHGKEIAEAFIREKLFPSIEDITA------- TRNSLGFESSGELKVSGELLYSLVGAVNFFHGKNKAEEFITEKLVDQFEKISA------- SRDPASFEASGELKVSGQLVHSLIGAINFYHGKDVAEEFIGEKIMKGLEEITK------- SANSLGFESSGEMRVSGQMLNALVGAVNFYHGKEKAEQFINEKLVAGFENISI------- SYNSLSFEKSGELKVSAQVMYALVGAVAFAHGKKKAEEFIREKLLRSLEAITA------- SYNYVGFETSGEMKVSAQMMYALVGAVTFVHGKKVAEQFISEKLLPSIEDITS------- SYNHLGFEASGEMKVSAQMMYALIGAVTFTHGKTVAEEFISEKLMPSLEEISA------- MRDPKAKNYNGDHTINSTVLAALIGGILKTNGPAKTANFITGELLASLLKFAN------- TKGVNATPSS---KITSGSVYALVGAILLKKGEKAAHEFAQKVVQ--------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MSNAQHIHPYL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MSGLEHLQNLS------------- VKAPTLPPSNQQPYDRRIVNQLGDQLSSAHILHNNLRSGLRPTAGSA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MTSR------- --------------------------------------------------MSR------- -------------------------------------------------MTSR------- -------------------------------------------------MSSR------- -------------------------------------------------MTSR------- -------------------------------------------------MTSR------- -------------------------------------------------MTSR------- -------------------------------------------------MTSR------- ------------------------------------------------------------ --------------------------------------------------MSK------- --------------------------------------------------MSR------- ------------------------------------MSGLEHLQNLSIQPSNR------- ------------------------------------------------------------ -------------------------------------------------MSGP------- -----------------------------------------------IQPSNR------- -----------------------------------------PIQGQVQSHSQG------- ------------------------------------------MSGLENLQNLS------- -----------------------------------------MSGSIPPSGMAQ------- ------------------------------------------------MQRPP------- ---------------------------------------------MSTVPSGR------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------STQQQQTNSQPQSQYSQSAAK----------------------- ----------------MAV----------------------------------------- ----------------IGSHQPNGNGPVLK------------------------------ ----------------STQQQQIISQPQAQYSQLAAK----------------------- ----------------PRQQPIIQRGQSLTNIGGSSD--QNMPN---------------- ----------------INPSATQQQQYHHQQAQYAQQ--QALK----------------- ---------------------------EMNPQSPIPR----------------------- ----------------LPTQQQLQLHLQQKQISPTPV----------------------- ------------------------------------------------------------ ----------------MSSYALK------------------------------------- ------------------------------------------------------------ ------------------------------KRSPHEFIFKEELGHGSYSTVYKALDKKDL ------------------------------KRTPQDFSFKERLGHGSYSTVYKAVD-RST ------------------------------KRSPHDFIFKEELGHGSYSTVFKAIDKRSP ------------------------------KRSPHDFIFKEELGHGSYSTVYKAIDKRNT ------------------------------KRSPHDFIFKEELGHGSYSTVFKALDKKSP ------------------------------KRSPHDFIFKEELGHGSYSTVFKALDKKCP ------------------------------KRSPHDFIFKEELGHGSYSTVFKALDKKSP ------------------------------KRSPHDFIFKEELGHGSYSTVFKALDKKSP ------------------------------------------------------------ ------------------------------RKSPHDFLFREELGHGSYSTVYRVVE-RSS ------------------------------KRSPHDFIFKEQLGHGSYSTVYKALDKARN ------------------------------RRSARDYQFGAKIGEGSYSTVYSALD-KYT ------------------------------KRTPDSYVFLDRLGQGSYSTVYRAVERSNS ------------------------------KKTVKDYQFGTRIGEGSYSTVFSALD-VHS ------------------------------RRSARDYQFGAKIGEGSYSTVYSALD-KYT ------------------------------KKSVKDYHFGARIGEGSYSTVYSAVD-KQQ ------------------------------RRTARDYQFGARIGEGSYSTVYSALD-KYT ------------------------------KRTARDYQFGNKIGEGSYSTVFSAVD-LYN ------------------------------KRTARDYQFGTRIGEGSYSTVFSAMD-IHN ------------------------------KKSVKDYQFGTRIGEGSYSTVFSAID-LQT ------------------------------KHSPHDYIFKQELGHGSYSTVYKAVDKKNL ------------------------------------------------------------ KKPYAIKVCSKRHIIKEAKVKYVTIEKNTLNLLARGNHPGIVKLYYTFHDEENLYFVLDY GQLFAIKVCSKKHIISENKVKYVTIEKNTLNLLAHGNHPGIIKLYYTFHDSENLYFVLDF NKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKNHPGIIKLYYTFHDEENLYFVLDF KRIFAIKVCSKAHIIKESKVKYVTIEKNTLNLLAKAHHPGIVKLYYTFHDEENLYYVLDY NKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHAGIIKLYYTFHDEENLYFVLDF NKIYAIKVCSKKHIIQEAKVKYVTIEKNTMNLLAQKHHAGIIKLYYTFHDEENLYFVLDY NKTYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHAGIIKLYYTFHDEENLYFVLDF NKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHAGIIKLYYTFHDEENLYFVLDF ------------------------------------------------------------ QHQYAIKICSKRHIIGENKVKYVTIEKNTLNLLGQANHPGIIKLYYTFHDQENLYFVMDL NHFYAIKVCSKKHIIRENKVKYVTIEKNTLNLLAQGNNPGIVKLYYTFHDQENLYFVLDY NRTYAIKVLSKRHIVKENKIKYVNIEKTTLNRL-GQQHPGIVQLYYTFQDESSLFFVLDF GRNYAIKVCSKKHIIREKKVKYVTIEKDLLNMLAKGGHLGIVKLFCTFHDIENLYFVLEY NKTYAIKVLSKRHVVKEDKIKYVNIEKTTLHRLGQ-QHPGIVQLYYTFQDESSLFFVLDF NRTYAIKVLSKRHIVKENKIKYVNIEKTTLNRLGQ-QHPGIVQLYYTFQDESSLFFVLDF GRTYAIKVLSKRHIVKENKIKYVNIEKLTLHRLGQ-QHPGIVQLYYTFQDESSLFFVLDF NRTYAIKVLSKRHIVKENKIKYVNIEKTTLNRLGQ-QHPGIVQLYYTFQDESSLFFVLDF NKTYAIKVLSKKHIVKEDKIKYVNIEKTTLHRLGQ-QHPGIVQLYYTFQDDQSLFFVLDF SKTYAIKVLSKRHIVKEDKIKYVNIEKITLHRLGQ-QHPGIVQLYYTFQDEKSLFFVLDF NRTFAIKVLSKRHIVKENKIKYVNIEKTTLHRLGQ-QHPGIVQLYYTFQDESSLFFVLDF KKCFAIKVCSKRHIIKENKVKYVTIEKNVLNSLGRENHPGIIKLYYTFHDQDNLYFVLSY ------------------------------------------------------------ ASGGELLSLLHKMGTFTDSWAKHFAAQLVDTLEFMHARGVIHRDLKPENVLLSKEGILMI APGGELLQLLQTQGRFNEAWTKHFMCQLIDALEYIHGCKVVHRDLKPENLLLSSEGKLMI APGGELLCLLHRMGTFNELWTRHFTVQLVDALEFIHSHGIIHRDLKPENVLLDKDGRLMI LPGGELLSLLHKMKTFSEVWSKHFTVQLVDTLEFIHSQGVIHRDLKPENVLLDRDGKLMI APGGELLSLLHKMGTFNDIWTRHFTAQLIDALEFIHSHGIIHRDLKPENVLLDRDGRLMI APGGELLSLLHRTGTFNDLWTRHFTVQLIDALEFIHSHGIIHRDLKPENVLLDKDGRLMI APGGELLSLLHRMGTFNDVWTRHFTVQLIDALEFIHSHGIIHRDLKPENVLLDRDGRLMI APGGELLSLLHKMGTFNDTWTRHFTVQLIDALEFIHSHGIIHRDLKPENVLLDRDGRLMI ------------------------------------------------------------ APGGELLQLLRRQRVFSEAWARHYMCQLVDTVEYIHSMGVIHRDLKPENVLLDKEGRLMI APGGELLHLLQRYGTFDEVWSKHFMCQLVDVVEYIHSKGVIHRDLKPENVLLSKDGRLMV AEYGELLSIIRKFGSLSESVSKFYMCQIIDAVRFIHSKGVIHRDLKPENILVGHDFNLKI VSGGELLALIQRLGRLTEDLSRHITAQLVDTVDYMHSKGVIHRDLKPENVLLSQEGRVVI AEYGELLSIIRKFGSLSESVLKFYMSQILDAVSFIHLKGVIHRDLKPENILVGHDFNLKI AEYGELLSIIRKFGSLSESVLKFYMCQIIDAVRFIHLKGVIHRDLKPENILVGHDFNLKI AEYGELLSIIRKFGSLSEQVLKFYMCQIIDAVSFIHLKNIIHRDLKPENILVGHDFNLKI AEYGELLSIIRKFGSLSEPVSKFYMCQIVDAVKFIHSKGVIHRDLKPENILVGHDFNLKI AEYGELLTIISKFGSLSESVSKFYMLQIIDAVKFIHSKGVIHRDLKPENILVDYNFKLKI AEYGELLSIIRKFGSLSEAVLKFYMCQIVDAVKFIHLKGVIHRDLKPENILVAHDFSLKI AEYGELLSIIRKFGSLSEAVSKFYMCQLLDAVKFIHSKGVIHRDLKPENVLVGHDFNLKI AINGELLQLLHKMKTFNEVWSIHFCAQIIDALEFIHSKGIIHRDLKPENILLDKNSNLMI ------------------------------------------------------------ TDFGAAAT-----------QNNFSDKDN--TRSNANEGIPKDDVPSSGDKTECSSFVGTA TDFGVA-----------------------------------SNLAATDNLSSTSSFVGTA TDFGAAST--------------------IDSSLSDNSSRCNSESNSINDNQSCASFVGTA TDFGAA---------------------------------YTTTAGNNDANKSSSSFVGTA TDFGAAAT--------------------IDPSLSGDSAKFNSDSNGSKDNQNCASFVGTA TDFGAAAT--------------------IDSNLSENSTRCNSDGNSVNDNQNCASFVGTA TDFGAAAT--------------------IDSGLSDDSTKYKSDDNCPNDNQNCASFVGTA TDFGAAAT--------------------IDSGLNGDSTKYNSDSNSSDDNQNCASFVGTA ------------------------------------------------------------ ADFGAA-------------------------------YTVGQSDAGSDGDKPATSFVGTA TDFGAASV-----------------------------VTTDGTSSDNSVSERAASFVGTA TDFGAAKL----------------LGNHEEFNGEKIDYNSVDASPEVSDTDRKGSFVGTA TDFGAA---------------------------------CTAADRKFENTKRTASFVGTA TDFGAAKL--------------LGNTSDESGEKIDYKGINQESNNGHHDHDRRGSFVGTA TDFGAAKL----------------LGNHEEFNGEKIDYNSVDASPEVSDTDRKGSFVGTA TDFGAAKL----------LDDAPGDSTEEIDYRSFEGGNDALANSATKTPDRLGSFVGTA TDFGAAKL--------------LDTNDDSSTTEKIDYNSIDPAMREVSTNDRKGSFVGTA TDFGAAKL----------------IGNDDDSQDEKINYDTVNLNASKELSDRKGSFVGTA TDFGAAKL-----------------LGNSDDNDEKIDYNSVDEAQNVSDEDRKGSFVGTA TDFGAAKL------------LGEEDDNEEKIEYNDIHSNGSPNVNTSVDDSRKGSFVGTA TDFGAAQK----------------------NNDNKENITTKSNGSHPCLVNTNSSFVGTA ------------------------------------------------------------ EYVSPELLLYNKCSFGSDIWALGCMVYQFIQGFPPFRGENELKTFEKI--VSLDYSWFGT EYVSPELLLQNKSNFCSDIWAVGCMLYQFTQGTPPFRGENELAAFEKI--VNLDYHWIYM EYVSPELLLYNQCGYCSDIWALGCMIYQFLQGQPPFRGDNELKTFEKI--VALDYPWP-- EYVSPELLLHNQCSFSSDVWALGCMIFQFVTGSPPFRGENELKTFEKI--VALDYPWLNN EYVSPELLLYNQCGYGSDIWALGCMIYQFVQGQPPFRGENELKTFEKI--VALDYPWP-- EYVSPELLLYNQCGYGSDIWALGCMIYQFVQGHPPFRGENELKTFEKI--VALDYSWPP- EYVSPELLLYNQCGYGSDIWALGCMIFQFVQGHPPFRGENELKTFEKI--VALDYPWSS- EYVSPELLLYNQCGYGSDIWALGCMIYQFVQGQPPFRGENELKTFEKI--VALDYPWP-- ------------------------------------------------------------ EYVSPELLLENKSYYSSDVWALGCMLYQFLQGTPPFRGQNEMETFEQI--VNLDYTWRIP EYVSPELLLNNQCFFSSDIWALGCILYQFMQGSPPFRGENELQTFEKI--VSLDYHWKLA EYVSPELLKHNICGFESDIWAIGCILYQFFNGVPPFKGSTEYLTFEKI--INVDYSYPIP EYVSPELLLHSQCGFSSDIWALGCIIYQLNQGKPPFRGENELQTFEKI--VALDYKWLFS EYVSPELLKHNLCGIESDVWALGCILYQFFHGNPPFKGSTEYLTFEKI--INVEYKYPNA EYVSPELLKHNVCGFESDIWAIGCILYQFFHGVPPFKGSTEYLTFEKI--INVDYSYPIP EYVPPELLKLNICGFESDVWAVGCMLYQFFNGTPPFKGNTEYLTFEKI--IQLDYSYKAD EYVSPELLKYNICGFESDVWAIGCMLYQFFHGVPPFKGNTEYLTFEKI--INLDYSYPVP EYVPPELLKFNECGFETDIWAIGCILFQFFNGSPPFKESTEYLTFEKI--ISVSYSY--R EYVSPELLKHNICGFEADVWALGCILYQFFHGVPPFKGNTEYLTFEKI--INIDYSYRLK EYVSPELLKHNICGFEADVWALGCILYQLFHGQPPFKGSTEYLTFEKI--INVDYSYRQG EYVSPELLLYNHSGYGSDIWALGCMIFQFLEGLPPFRGENELKTFEKI--VALEYKWSDQ ------------------------------------------------------------ --INIQVVNLVRRMLTIDTTQRAT-----IDQIKRDPWFANVDWGDKKKLWRGIWAYISP --VSQHITDLVSKILVLDPDSRYT-----LPQIKNHAWFQGIDWTNKELIWKGIWNFNGP --VNPLAINLVRKILVVEVNERIP-----LTVIKKHPYFAKIDWNDKVKIWRGIWGVPSS --INPLIINLVRKILVLEPKDRLS-----LKKIKQDPWFATVNWNDRNTIWKGIWLQLPP --INPLVINLVQKILVIEVNERIS-----LEQIKRHPYFSKVDWNDKIKIWRGIWGLPNP --VNPLVINLVRKILVVEVNERIP-----LKLVKRHPYFAKIDWNDKAKIWRGIWGALPN --VNPLVINLVQKILVVGVNERIS-----LKLIKRHSYFSKIDWNDKAKIWRGIWGTLPN --INPLVINLVQKILVVEVNERIS-----LKQIKRHPYFSKVDWNDKVKIWRGIWGLPNP ------------------------------------------------------------ --ANPLAAGLVSKILVLDPSQRYT-----LEQIKKHKWFSGVDWNNKEKIWRGSWESTPP --VNPSVMDLVRHILVIDPHERLS-----ISAIKQHRWFQDVDWANKDRIWLGIWQLPQP --LPPDVIQLIDSILISEPSARAT-----IPHIMSSRWFSDIPWDDQNFIWHRKVPAMPP --NSPQVVSIVQSILVTDPLKRPS-----AAQLKQNPWFASIDWDNRSSLWKGIWGKNTP --VPPDVVTIIDQLLVAEPLQRLT-----IPQIMASRWFSDIHWADQTYIWGRKVPRIEP --LPPDVIQLIDLILVSEPSARAT-----IPRIMSSKWFSEIPWDDQNFIWHRKVPAMPP KPVPEDVKFIIDNILIENPSQRLT-----LPAIMSAKWFHGVNWTDKAYIWQRKVPLQTP --LPSDVIQIIDQILVIDPAQRIT-----IPQIINSNWFSEVPWDDQNYIWHRKVPRFEP NQVPPLVKDVIDSILVFEPEKRLT-----IPQIQSKQWFAGVPWNDREFIWNRKVPRFEP YPLPPDVIEIIDKILLADPQQRST-----IPQIQKSRWFQDVPWDDLNFIWHRKVPRFEP YVLPPDVTSLIDQILVADPSSRPS-----LQTIMGARWFSNVLWSDRNYIWGRKVPRFEP FKISSLVKDLVRKILTVNPQDRIT-----LSEIKKHSWLNLVDWDNKQKIWSSVWINCPP ------------------------------------------------------------ SLQNRQLHVIDTPLRNIPVTKQKRKKPAKEFNTTSSIVEWRKKLGIASSSTHNSTQSISN SMMNKQLHVIDTTIKNIPIQPRKR------------------------------------ SLPIRQLHVIDTPARNIQITKQKRK----------------------------------- V------NSSSSSSSTSSASVSIPEYSIPSTINTISTSTTPRSSAHQHLLPSRQLHVIDT QLPTRQLHVIDTPARSIQITKQKRK----------------------------------- LLPTRQLHVIDTPARSIQITKQRRK----------------------------------- SLPSRQLHIIDTPARSIQITKQKRK----------------------------------- QLPTRQLHVIDTPARSIQITKQKRK----------------------------------- ------------------------------------------------------------ RVGYKSRELLDTPIKNIPVVTQRN------------------------------------ RVMNKQLHVISTPVRNIAITTKKK------------------------------------ MYHQLQSQISASEFGFIPSIAAKKSYKPPTMIKNNVAMPALNQTTYNHNYQQHVPLPPPV R-GAQQSHTNGVPAGGLRITRRK------------------------------------- YHQQLHSQIQQLDLNLIPSVGSKTYQPATKIKKNFMPPTSASAEVPLTPPLTNNYKSPAS MYHQLQSQILASEFGFIPSIAAKKSYKPPTMIKNNVAMPALNQTTYNPNYQQHVPHPPPI FLYAQQNQGGIPQVRQAAPSNTEYKVPGVNPNANSSATNYNTNYNANYNANYNANYNPNI FYHQLQSQIQASEFGFIPSIAAKKSYKPPTAIKKNVPIAPTNQMAYNNGNFSPSPIIQPS FNYQLHSQIQQYDYNLVPTIGSKKSFQPPTRIKKGVPSSNSPLPQQNFVPTHRFDGTQHP FYQQLHSQIQHSDFAYIPSVGVKKSYQPATRIKKNIVAPQQLGPPAQILQQTQQQPPPPA Y-YPPGTAPAPTNYSYMPPSRNMNKSSSYQQLHSQIHASDLNLVPMGKKTYQPATKIKKN VINDRQLHVINTPLRNIPITKQKKKKK--------------------------------- ------------------------------------------------------------ IVVDSFKPELPTNKVIITKEIPVGNVSINQVGANLDSQSPIPTSMKLQNQPSNKELNRTP -------------KPMKVTQTTSSIVEWRKTLGLSPVSGSVGPNGLPKQMKSHVPSRSTP -------------KPTKISSTTSSIVVWRKRLGISTGKDDLGTVPSTAPAIIVPNESTIS SIRNIPITKQKRKKPTKIPNTTSSIVEWRKKLGISSNNNNNNHVLTNIDITDTEGLSIDT -------------KPTKISNTTSSIVVWRKRLGISTGKDDLGTVPSTTPAVTAPNDTNVL -------------KPTKVSNTTSSIVVWRKRLGISAGKDDLGTVPSAAPNDNNILNATAA -------------KPTKISNTTSSIVVWRKRLGISTGKDDLGTVPSAGPTMITASDSNIS -------------KPTKISNTTSSIVVWRKRLGISTGKDDLGTVPSSSPAMTAPSGNNVI ------------------------------------------------------------ -------------KKPTKMNTTSSIVEWRKMLGLSGNDLGIKATLGGNGLPIAPFTPTSG -------------KPVKIANTTSSIVEWRKMLGLSNGNALPRKPVSAQQYPSQKKPQL-- SSQPLTQQNVPQQIQPQRSGSAQTPQFAPVSASSRQPVGNMQTRQAAPQVLVQQKTPPFP ---------------PVQATGTTAIAEWRKKLGLGVETLP-------------------- GQFSQRPMQKQRQNSAPVVPQMNNGMNNIARLNMANTPRTPEAEHGFPKPNPSPDANKGQ SSQPVVQQNMPPQIQPQRSGSAQTPQFAPVAAPNRPPIASMQVRQAGPQVLVPQKTPPFP SAGYNVSSNINSNFNTNINSKANSNTKDIKTNANLNTNLNANTGNTIGNTNTNFSNNATS APPPQTPPSPSRGQQFQHQQQQQQNRNAPAISAAASSMHHQNGNTQVRQQQSVPPQQSQD QDRNFVPPPQNIHTNAWVSPQGGINPQANPPIRPAPQSNGIKHKVPTQSNQAETASQNAA PLVPPISPTHPAFVSAPSPPRTQNQHHAHAYRAQMLQQPNMTLPPSQQQQQPQQSPLDSP VYNHLPQNSPIPLKPTNAMGVPTPVLVNNNSPPKVAGPPPPRSVPITPSVPTDSSMQMSP -------------KPTKVSNTTSSIVEWRKRLGISSLNISNNSNSTANSNSSNSSLDLTT ------------------------------------------------------------ QTIHPIPAINSLNSPTLPNPNPNPIPPEPAIVSASQSNFVNPAHIGHNSAVREIAETKKR NSPSRALTGKGYTKAMPNT--------APPLETCKTPMMPVSPLYITTPGASASFSPKKF TATVTHLSSNSASPASSQPIQVQTKRTPPKALVNSANIKNKPIPRQKAIV-PTLPTPPPP ELSSSNFITNPPPPPPTQILRQHSQSSSPTKNKMGPTLMMNNNGISENQTQDHIIPSTPP TNTAAHSTANIALPPNSQSNQVKRAQLPPKVPVINDNVRNKSIPRTKPNVPPLQTSSIPQ VSSSNSVIPPNSQPIQAQAKRTQPVAPPPKVPIISNSVRNKPISRQNTALPSPVIRSVSP TSTRAHSAPNVNSPQNSQSNQAKRMQPPPKVPVVNVNMRNMSTPPSKSANPPSKPVNPPS TNTVPQSTSNVTLPVNSQSSQVKRAQPPPKVPVINDNLRNKSIPRTKPIVQPSQTTSIPQ ------------------------------------------------------------ I--------------------------TPDNRGDNAVAPAKTRDAFRPMSSRVISSPHSK ---------------------------APPLKITTPPPPSTMASKNMRPPIPNVCIPTTK KEKNSTPNLRDNTSFAQMAPRRNGEIPLPKSQQSPQPQPKAQYQSQQQKQSEDIRGSKNT ---------------------------SPPPSGGNKAVNINAPLTKVRPSTPTSLTPPPS RANLRSNTAFAGIASSQQARNFHNRQYSPTIPQMNRNSPVERNSFQRPSPPVSRPRSPQQ KEKNSTPNLRDNTSFAQMTPRRNGEIPLPPPPPPPSQKFVYQLQQQKQQEDVTGSRNTST HSNANSNAITNMGLSIHNNSQSNSVQSAPSTQQGASTPQLHPKNTVTNSSQQRPLVPNTI QTPVEKKRMSNIRTNTSFANLVPSSNGTPQTQVNRSNEQISGKNAAAASAAAFASKPPTS KAAQQNSSSVQAVEKRIANVHIGSQSKSPQMKNLRSNTAFAKSQSYSSQSSAPPTSKPPQ SKSPHYTNLRTNTAFAMTNSTSSSDSNQPQPPAIPNLLVSAAAAAAAGSGMKQAQRLAPT RTPDIGKYPPVKTASPQQRNLRNNTAFIPPKPTTVPDPRPHPSRSSSAAAAAAAAGGIVQ SNDSNPVTNFSSNEVNQLNDMDKVADDPPEVKKEHISAPINNYPLPKSASMNKIPTTPKY ------------------------------------------------------------ DQQRNISNSNMNLNYTNSLEEVPQMNDGGLSNGVQDENRSRQSSTSNVEAEILKQDFVYV NNASDSNRLLTPPASP----------------------------------KALKQGWVKI LAPPPAPSAPSAPSAPSAPSASSAPSAPSAPSAPSASSAPSAPSAPSAPSSILKQDYVFV VPPFFPHSSNRSPISTSVSMSTLDKYLNNADINKNRKLAKDSVINITNE-SVLKQDYVYI KLSTSSASSALSAPSTEIRNQDLTHTLDGRNSIDI---------------HVLKQDYVFI KQPTSSVSSTPSAPLSLSAPSTEAQHQDVPQTLDERNPIDL---------SILKQDYVFI RTPPIPPQFSSASASASASVPASAALLESSIETQHQDAMQTLDGNSNTDIHILKQDYVFI QSSSSAGSALSGPSIETQHLDVTQSLDERNSIDL----------------HILKQDYVFI ------------------------------------------------------------ PSGRPAALPLPLQTGTPSHNVVQQIVVNTPGRTETSSPYVSPTVPVRN--AIWKQDWVQL PNTTVPTKQNKIPLNIKIPSQKQSDSSPPPIKLAHGLNSPD---------SILKQDLVLI SANAAAAAFATKNLPQPNHKTSKDSSTPPPPPPLPPKIKKVQENFIKFNEKILKMDNLIK APP-----------------------------------------------PLIKRDISSI DSTKFVKKTSSTREPPSKMNGNSSTTNEKPSETYTDQSIKFREIHGLLEPKILKMDVILR NAAAAAFATKNLPQQTYKTTNDSSILPAMKSKKVQENFIKFSEVSGLLKHKILKMDNLIK SSSSSWASSSSSQRKETPSNQHAGQRPSPSFTNSKSSVPPSSPRPSVPSSKILKMDSLYM TRPVIAHTPPPSTIPPARQQQQQLQTSSKSPRIAQAAPKTTKENCVKFKEKILKMDTLFK LNAISAAASATERIQSSQSGSRPKEKHTNPAKVSNANTVTFQEVSSLLKPKIIKLDTILK LPLAKLAIATKSKEDLKQKTTKTKIIEAKNTIKFKEISNLLSPNE-----KILKMDTILK QRSQQPPQQQQPQLPQQNKNSPKEAAPPKSKNNARAASPKNKPSGTTLLFKILKLDVVLK SQPSTKLKEKPVNP------------------------------------RIVKQELVYI ------------------------------------------------------------ KTISYDAAGPDMAINSYKTINDDLITSLVAKHKSSL--RPINIFPQLLVLYKDGSLAYKE LEIPYSSSKKTFSSTEYSFIDDRLITRFITEQKSQIINSSMLSLLTLEPNGQFSYTPKGD HGIPYEAEGPAMSLNSYNKIDNDLITSLVTQHKEELKSSRMFLQLLTLKKNGMLSYRSAV YTIPFKADGPAMCLDSYSQIDNDLITSLVSKYKTSLKVNTLPCILMLGKNGDLSYVKNNS YGIPYEHEGPAMSLNSYNKIDNDLITSLVAQHKEELKNSESFLQVLTLKKSGMLSYKNTV YGIPYKDEGPAMSLNSYNEIDNDLITSLVEQHKEDLKNSKLFLQLLTLKKNGMLSYKNTV YGIPYEHEGPAMSLNSYNKIDNDLITSLVSQHKEELKISELFLQLLTLKKNGMLSYKNTD YGIPYENEGPAMSLNSYNKIDNDLITSLVAQHKEELKNSESFLQVLTLKTNGMLSYKNTV ------------------------------------------------------------ HEIPYSAKYSGLTLAGFSQVSDTLIADLISHHANEL-RTLSRTGILSLDNTGYLSFIEQG FEIPYSKNVPTLSLRGYSSVDDTLITSLVTNHQREI-VTKSKPAVLTLDYHGDLIYEYNS SVLSK----RYLNKPEYQVLDDSVLDELTSKYASILKQESKAVITIVTNMARVFFIDAFL LEIPYDPSKRTMSLNGYSSIQDESITEFVSRNKKAILNSSTNCIVALDLKGNLTCQGPNQ LTLSN----KEVNRDTSQLLDDSMIDDLITRFNNTLERTSVPVITVITNQARVFFIDGSL LVLSK----KYLNKPEYQVLDDSVLDELTSKYASILKQESKVVITIVTNMARVFFIDASL VRLEK-----SLVGLNYNTLDDMLLEKIIARNGDYLKKKATTVLTVITNMARIFFINNNL SVLGH----EYLSNSQSEVLDDSVLDKLTTENKGILTGDAKIVIAVVTNMARVFFIDASL SILSN-----NLIGKKPGNLDINMIETLIKKHGEVLSSNMVPVVACISNMARVFLIDSSL LELSN----KILKRQPAEQLDDSLIDDLITKYLRQLEKNAEVVVTVITNLARVFFVTASL SQLSN----KVIKRDQREVLDDTVIEKLVRKYDSELQKTLKPVVTIITNLARVFFIESSL HEIPYNEAGAEMSLTGYKNIDNDLITSLVSNHGSELREDLTPDLLTLYKDGSLIYKTIKK ------------------------------------------------------------ VNTESRKGEKALNPMVNLGDVNLSMYDFEFD------------ESLRRGFLILEKYKYKL STRQMISIVDQNLSIYDLEFNETKGYLIFEK----------------------------- -QEDRDNQGNIDHQMANIEDTDLSMY--DFEFLSRKG------------FLILEKYKNKL PTSPTA--SKNSELMVNVADSDLSMYDFEFD------------ELARKGFLILERYRKKL -MEGNDDQENKEHQMANIEDTDLSMYDFEFN------------ELTRKGFLILEKYKNRI KKDDEKNLGNKEHLMANIEDTDLSMYDFEFN------------ELSRKGFLILEKYKNKL -MEENESRQNEEHQMANIEDTDLSMYDFEFN------------ELTRKGFLILEKYKKKL VMEENEDQVDKEHQMANIEDTDLSMYDFEFN------------ELTRKGFLILEKYKNRI ------------------------------------------------------------ RARPLSRIIDPDLSIYEYQLGHST--EDDFL--------------------ILEKYKQSI THTTMVSIADSDLSMYDYEFDEAK----------------------NRGFLILEKYRDRL NVMLVDLKANKGADYSMYDYEFENTVDEDGN-LSKQDETFGYLIIELIKDGGDLVFLQRV PPKLMISVADPDLSMYDFEFDETT----------------------KNGFLILEKYKSRL NVMMVDLKANQGGDYLMYDYEFESISVEDED-IEEGQEVYGYLILELIREKGDLIFLKRV NVMLVDLKANKGADYLMYDYEFENIVDEDGN-LPKQDEAFGYLIIELIKDGGDLVFLQRI DAMLVDLKANKGKDCLMYDYEFEGDDDDDEQGKETSVEELGYLIIELVRENGDLIFLKQS NVMLVDLKANKGADYSMYDYEFENVVDDDGN-IPESDEVFGYLIIELVKEGGDLVFLKRI QVMMVDLTANEGGDYSIYDYDFESVVVGDDR-GSNGEEVYGYLILELIKEGGDLVFLKRF GVMLVDLKANNGGDYLMYDYEFESLAVDDDG--NDSEEVYGYLILELIRKGGDLIFLKRI DVMMVDLKANNGGDYSMYDYEFESIAVDGDE-VLNGEEVYGYLILELVREGGDLIFLKRI KKNTNKVKSYEELLMVNIADSDLSMYDFEFN------------EVTKSGFLILEKYQSKI ------------------------------------------------------------ WFISLPSYSLLATFPRELTTRLLINNNEKWIDSFFRTRKIIENGFDIDKKIEGLDIKEKK ----FKSKVWLIALPKSAPSDFVINSRQKWVDSLFKTKAALESEKLTKKVDN-------- WFISLPSYSILSKIPSNVEKSLTINNNENWVDCFFRARQLLEEKQILDKISNVSFDSKVS WFISLPSIPILSSISPPSQTSLVVNREKGWVDCFFKARQLIEEDEKRVVDKVKGIKLSPP WFISLPSYSTLSKIPFNAVKSSTINNNENWVDCFFRARQLLEEKQILDKISNVSFDSKAS WFISLPSYSILSKIPFHVVKSLTINNNENWVGCFFRARQLLEEKQILDKISNVSFDSKVS WFISLPSYSLLSKIPFNAVKSLTVNNNENWVDCFFRARQLLEEKQILDRISNVSFDSKVS WFISLPSYSILSKIPFNAVKSLTINNNENWVDCFFRARQLLEEKQILDKISNVSFDSKAS ------------------------------------------------------------ WIVWPNKPTSAS---------RRIPIKETWAQTLSKYKKQVSDEEELSAKLNRTCVSSWG WFLSLPTAQYDIQY-------RKIHTQESWVECFFKARQLIEDKSLMEKLARVSLDSNSP SDEQRLRLTNAVKVLDKKGEEVVVGSSHGWIDCLLIAREISIEQSEDNKKPRSVSSSSNV WFLSAASPKQSLPMNFRP-----LSREKTWVDCFFTARNVVTENNGKKATPPATAPPAVS SDMNSPLIKESVKVLDKDGHEIKLGKNYGWIDCLLMAKEMVDTNKTSNRNGK-------- SDEQRLKLTNAVKVLDKNGEEVVVGASHGWIDCLLIAREISIEQSQDKKQPRSVSSSSNV QTPKSKQMAKELKVLDKHGNEVLIGADHGWIDCLLIARETSFSSEATSTSASSTSSTSSS SDRERTKLGNMLKVVDKHGHDVVIGTSHGWIDCLLIAKEISMEQYLEVRSATSGASSSNN DETDKAQFQNPTHVVGKTGQHIVLGTNYGWIDCLVYAKQMVDKVSNEQKL---------- SDFERLSLEDSVKVVDRSGDQVKLGKNYGWIDCLLMAKDMVSREKSLPAVRKEKSPTPTL GPMDKLSLKQSVSVVDKNGSQVTLGKVHGWIDCLLIAKDMVDKREVSKEA---------- WFISLPLLNFLLPSTPFKSES--INREESWVDCLFKSRQLLEDQQLITQMMSKTSIEQKV ------------------------------------------------------------ ETPAGKPKDELISPTTEKNGSLPPKKADSIKSKKSISSSLNSSTPPVLKKKQATDVKEKP -------------------------------------------------------LSLKP NETVSPSPSPKKDPTPSVSNGVTPPAYNTKYGSQNNIQQNNNVKQETFSRIATMGRDKPS AEKSKIPKGLDSTVTISNEKTNNASYKTNSTTTLKIATSTFPTKKEVPQAQLTSDTFPAT SEPSSPPPISRKERPLSIGNNVTTLSYTAKNGSQNNAPQNDNVGEEKPFRIPSSTKDRPG TQSPSPSSTSRKDHTPSIGITVAPPSRNSKQGSQNKVPQNNIIKEEMPSRVPSNVKEKPS TETSSSPSISRKEHTASIGNIVAPPNHNSKHEIQNNVSQNKNIGEEIPFHIPNSVKNKPT TEPSSPSPISRKEQPLNIGNNATAPGYTAKNASQNSVSQNSNIGEETPFRISSSVKDRPT ------------------------------------------------------------ SRTPSPTYPAEGKTRVAVQPQDIPLPSPAKSSSNSGVSEPISKIPPRQLVSASEQSHKAK TPPSYESAGPSSAGTNITMVTTTSNSTISTTKTAPSFTSQTKENKKRIDVKPPRSKLPTL -------------------------------------------------------SINEV AAP----------------------------------------------------ISPAI -------------------------------------------------------TKNAP -------------------------------------------------------SINEA TTP----------------------------------------------------ATRSP -------------------------------------------------------SIYDV -------------------------------------------------------KGPKI SP-----------------------------------------------------SLSSK -------------------------------------------------------PKKKK APKKGNLEGNNNSYPATNTLLPSPPTSASSKKELHVSTNKVKQQVRRSSQGIPSNKHTVA ------------------------------------------------------------ LSKESMNSSTTKTKKPIKPKLRQPPHINTGHSSLVNTTNSGRKRSVSSTPSTPQSPVPNM PETCSTSSKPRKSPQDNMFVSSSRAEVLYTLNKQKRSNTDAANGARAAFKNMNK------ VNPASAVVHSKVLSGNNTNRTTRKTSAGLPNSAPSVNTYSNNTIPISGNR-STNSTNNKQ NTSETTVAKNNGFVPPSKNLNNNNTNNIMKGKQQSLVSKRVTPIATKDRTVPTAQVSTSS ANSTPSSRHPRVLSSNNAGETPKKMNGRLPNSAPSTNTYTNGSVPAFNHRPSTNVGNNKH VNSTPLTGHPRASSGNDTSRTTRRANGGLPNSAPSVSAYNNNTVPISNHRSTTNLMNNKS ANSAPSFKQPRVLSGNNLSRTSKKTNGGVPNSAPAVNTFNNSTVPVPNHRPSANLTNNKH VSSTPSSRHPRILSGNNASRTAKKTNGGLPNSAPSTSTCNNGSAPVVNHRPSTNVANNKH ------------------------------------------------------------ SEAHTKKANSYSYIAPNDMVLSSSRYEVLRTASNNDSKSNGAAVSGASAAFRTLRVNK-- PQSPVTSSSPVLSKPPPRNRSASRTPSSPKVGGKPFSPSIGRPITRPSSSPSLSRDSNMP KSEKAKKKNSSLSNKKPRSKKKGTSSNGTPQTTPPPTQHSNFAFAAAAAVHHQK------ PTVPTVPTVPAVPATSATSAAKPRPRPRLNAPANMMVSSSRFEVLHALSGPGSKSGDASS KQTQKVPGKKPKQKVPSSSSTRSETSSSVPKNASKLAYAAAAAAHK-------------- KSEKSKKKKPSLPNKKPRPKKKGTSSNGTPQTTPTQSQPSNFAFAAAAAVHYQK------ TTTSGVPSRSNKPKVTNSKQTKSTSIVDKQTVSNPNGTRKDAAKRKVADTRSLRSKNSPN KTEKSKKKSSSSSSSKKKASKSKKKSTSNGYSTPPQGQSSKFAYAAAAAVHNHK------ SKSQTKPTIKKSTTQKHSRPGAPTTTKKSQNPSDSKTSTNKFAYAAAAAAHR-------- SSSVPTAASKKKPTKTTAVPKKPKKSTVQTNTGRSTQPTAAKPMSKFAYAAAAAAHK--- KNKKPTATNVTILPTRPSSSSSTSTANFAYAAAAAAHSRD-------------------- HVSNSAPPSPGPSPNSTIRSHATKAPIKKYTAPSNMVISSSRYEVLQTLRKEGPFDPNYY ------------------------------------------------------------ KVPPRPGSV----------------------------------------MDGHTKSKRTR ---------QEQLQDMNDGVEMFQGIPSTLANEHDDDHDSNHETHHSSSSSSKPKSKRTR TPLPSKRQN--------------------------------------------------- RIKHPHYMIHSNMINNLSSNNPSVMPPTEQQEQEQGNNTPPSSSSNSASVKRMPKSRRKR NILTSKKQGATDLDYQHQHNQQQQPQPQPIQTHDHDQHTNDMSASSNASDSGPQRPKRTR NYSTSKKENASDLDYQHHHQHLQQQQPSQIKNQDQDQHINDMSASSNASDNGPQRPKRTR NLATSKKQSATDLDYQQQDNLQQQQQTSHMQNQEQDQHTNDMSAASNASDGGPQRPKRTR NLSTLKKQGATDLDYQQQQQQQQQQQPIQMQNHDHDQHTNDMSASSNASDSGPQRPKRTR --------------------------------------------------------NKXK ---------MDNFEYMLGHGELRSDNGE----ATGNSKSPGHGELAEAADGGKPKSKRTR QQELYKKYNYDSNDFAPNSTANSDDQTTGTTSSFSSNYNDQKSAHLQQGNDGKPKTKRTR ---------MSPDSI--SSVNQDLSTPTP--------PTSLSSTSTNSNTNASSGQKRIR GASAAFKSSMQEYQGTTSFGNGDLNEQRE---QSEQREQSDQQESNTGSRDDRPRTKRTR ---------MSSDEY-------------------------------------GSSSKRTR ---------MSLDSI--SLGNQELSTPTP--------PTSLSSTNSNNNNNVSSGQKRIR LSNSPSSFNMSETGL-----LSISGTKTS---TSGNTNVNDSPTKTSPSLSQHQPQKRIR ---------STSLES------------------------PVQPQPPPSEQSNQPTQKRIR ---------MAEETS----------------------------------------TKRTR ---------MSSDEN------------------------------------STTSNKRTR ---------MSDDNG----------------------------------------SKRTR KTKEELNTNIYDEFYQVDSMTRQLNGLVSPQLSRDESNGLVESFDGEQEQEQEQKQKRTR ------------------------------------------------------------ AKGESLDILKSSFQLNPNPSLQERNRISELTGMPEKNVRIWFQNRRAKVRKKGKLDGDKP ATGEALEILKREFQLNPSPNAQNRKRISEMTGLPEKNVRIWFQNRRSKYRKSDKR--MNG ------------------------------------------------------------ AKGEELNILKSHFELNPNPSNEERKKISNLVGMPEKSVRIWFQNRRAKVKKHNNLKNRNN AKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKK-----QHG AKGEALDVLKRKFEVNPTPSLVERKKISDLVGMPEKNVRIWFQNRRAKLRKK-----QHG AKGEALDVLKRKFELNPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKK-----QHG AKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKK-----QHG ------------------SYITEKKKSSEMTGLPEKNVRIWFQNRRAKSRKDDRAGVRDG ATGEALELLKKEFDINPNPNAQNRKRISEQTGLPEKNVRIWFQNRRAKYRKSDRTFNQRT ATGEALAILKREFDVNPNPNAQNRKRISDMTNLPEKNVRIWFQNRRAKFRKSGRQNP--- ATGEALEFLISEFETNPNPSPERRKFISDKAQMNEKAVRIWFQNRRAKQRKFERQMLDSP ATGEALNVLKREFDQNPNPNAQNRKRISELTGLPEKNVRIWFQNRRAKHRKSDRGG-TRG ASGEVLDYLLLEFENNHNPSPEQRKEISDRTNMTEKAVRIWFQNRRAKLRKFERMGRNEG ATGEALEFLISEFERNPNPSPERRKFISDKAQMNEKAVRIWFQNRRAKQRKFERQMLDSP ASGEVLNFLITEFNKNPNPSPDRRKVISDKAAMSEKAVRIWFQNRRAKQRKHERSRKLDT ATGEALEFLISEFQKNANPSPEHRKYISQKACMNEKAVRIWFQNRRAKQRKFERQRLSTG ASGEVLDYLLREFDSNPNPSPDQRKEISERTNMSEKAVRIWFQNRRAKVRKFERMGKHGG ASGEALDFLLQEFEKNPNPSTEQRKDISSKTNMSEKAVRIWFQNRRAKLRKFERLNRQTG ASGEVLDYLLEAFKQNHNPSPEQRREISEKTNMSEKAVRIWFQNRRAKLRKFERMGKDSG ARGEALDILKSEFNLNPNPTSKRRKVLSELTGLSEKKVRIWFQNRRAKVRKSDKLGKNSN ------------------------------------------------------------ KLHDGESRVVSGTGAGATATAGPGAGAGVTRTQGVDTSGPPYFDKLPLNINNNYYFIDVF PGATDNTTLVSSF----------------------------EFDKIPLAINSSYYFIDIS ------------------------------------------------------------ ANMDSNDEDFNDETSPN-----------------TDSNNAKFFDRIPVRINKNYNFIDVC SNKDTIPSSQSRDIANDYDRGSTDNNLVTTTSTSFHDEDLTFFDRIPLNSNNNYYFFDIC GNKDPNPSSQSHDNANDYDRTTTDNNSVTTTSTSFHDEDLTFFDRIPLNSNNNYYFFDIC SNKDANSSSQSRDSANEYDHTTSENHLVTTTSTSFHDEDLTFFDRIPLNSNNNYYFFDIC SNKDPNSSSQSRDIANDYDRGTTDNNFVTTTSTSFHDEDLTFFDRIPLNCNNNYYFFDIC SGGSTGDNTGDSNAFYS-----------------YDNGENSLFDQIPXNINNNYYFIDIC AATDMNT---------------------------FGSISVTEYDKIPLNINDNYYFIDAN ---------------------RPSALDMNG----IGSLSLTDFDRIPLNINNNYYFLDVS GNYAGIYNTYTPNPP--TVTTDMTNFNVNGSAGGADFNDKLNISSIPVEVNEKYCFIDCR SATTDVAGE-------------------------PTGAIPADFDRIPLDSNSNYCFIDVK GKRHTAS----------IHSSRSNSFNEPNRSPGLTPTIP----SIPIEINEKYCFIDCS GNYAGIYNTYTPNTTG-VASTNMTNVNTNGTGTTFNNKLNN-ISSIPVEVNEKYCFIDCR NAYHIQPHHSSSSTFDLQRPTSSTTSTSTSPPQSFSNNSPS---NIPIEINEKYSFIDCT GVND------------------------------FTTGLMKSNNSIPIQINDKYCFINCS SNVSSRSNSLTQ----------------------VSAAGLRAQGMIPIELNENYCFIDCS GSS--------------IHSSRSNSISN------ISPIHPNGNQAIPIEINEKYCFVDCT STGDASPYSA------------------------SSSARFESSPPSPIDISEKYCFIDCS TDLTRIKSYGDGFDD-------------------DSEDTVSFFDRVPLEANKSYSFIDIF ------------------------------------------------------------ SITVGSWNRMKSDATDLMVVISKKNFEINYFFSNTKILFRIFFRINTVASCSLSKTDEEI SLTVGSWKRLKANATDLMVLISKKNFEINYFFSNTKILFRIFFPINTVVNCSLSNSNSPS ------------------------------------------------------------ SITVGSWNRKKSNSTDLIVLTSKKNDEINYFFSDTKILFRIFFPISSVKNCSLSTNNNVT SITVGSWNRMKSNATDLMVLISKKNSEINYFFSNTKILFRIFFPLSSVTNCSLTNNDDDN SITVGSWNRMKSNATDLMVLISKKNSEINYFFSNTKILFRIFFPLSSVTNCSLTNNDDDN SITVGSWNRMKSNATDLMVLISKKNSEINYFFSNTKILFRIFFPLSSVTNCSLTNNDDEN SITVGSWNRMKSNATDLMVLISKKNSEINYFFSNTKILFRIFFPLSSVTNCSLTNNDDDN SITVGSWNRMKSNATDLMVLISKKNFEXNYFFSNTKILFRIXFPINSVVNCSLSNSDQQD SLTVGSWKRLKSNATDLMVLISKKNFEVNYFFSNTKILFRIFFPINSVLNCSLLDANNVV SLTVGSWKRLKSNSTDLMVLISKKNFEINYFFSNTKILFRIFFPINSVVNCSLSNEDQDE SLSVGSWQRIKSN-ADLLIILSKKNLELNYFFSNSRILFRIFYPLNAVVKCSLFDNNYYQ SLTVGSWKRLKANATDLMVLISKKNHEINYFFSNTKILFRIFFPITTTVDCALSATTDGA SLSVGSWQRIKAN-VDLLVLLSMKNFEINYFFSNSKILFRIFYPISSILSCSLLDNNINK SLSVGSWQRIKAN-VDLLIILLKKNLELNYFFLNSRILFRIFYPLNAVVKCSLFNNNNNN SLSVGSWQRIKTQ-VDLMVILSKKNQELNYFFLDSRILFRIFYPLSAILLCSLHENSIED SLSVGSWQRIKNN-VDLLIILSKKNSELNYFFSNSKILFRIFYPLNSIVKCSVFKNNFNS SLSVGSWQRIKEN-VDLMVILSRKNHEINYFFSNSKILFRIFYPISSVLHSSILDSSLSK SLSVGSWQRIKTS-VDLLVILSKKNCEINYFFLNSKILFRIFYPISSVATCSLLDNNITK SLSVASWQRVRSS-ADLLVILSKKNSEINYFFSDSKILFRIFYPISSIVTCSLLDNNINK SITVGSWNRMKSDSTDLLVLISKKNYEINYFFSDTRILFRVFFPINTVVNCSLVTGDESD ------------------------------------------------------------ NNRTDPANQAELKLKVNKPPKFFLNQPENTNQWCLCEDFSEGKQVNDAFV--GGSVPHVL SLDGNNDTLAELRLSLSKSPKFFSETIDDSNQWSICEDFSEGRQVNDAFI--GGSIPHVL ------------------------------------------------------------ NSSDTSERLGELKLILTKPPTFFIKSDENINQWSICEDFSEGKQVTDAFI--GGSLPHVL DDNSNEDNFGELKLTVTRSPTFFLNNAPDNNQWSICDDFSEGRQVNDAFV--GGSIPHTL DGNSNEDNFGELKLTVTRSPTFFLNNSPDNNQWSICDDFSEGRQVNDAFV--GGSIPHTL DDKSNEYDFGELKLTVTRSPTFFINNSPDNNQWSICDDFSEGRQVNDAFV--GGSIPHTL DDNSNEDNFGELKLTVTRSPTFFLNNAPDNNQWSICDDFSEGRQVNDAFV--GGSIPHTL DENGESSLLGELKINVSRPXNFFLEAPDEXNQWSICEDXSEGRQVNDAYYWWIQF-TTCI QETTAPAAVCELKLNVSKPPNFFSDMNDESNQWSICEDFSEGRQVSDAYV--GGSFPHVL QDQDPSEKTCELKLTVSKSPKFFSDAVEHSNQWSICEDFSEGRQVSDAFV--GGSLPHVL NNNTNGTNISEIRLNLCQKPKFFFNGSNTNNQWSICDDFSEGQQVSCAFAQSFSNIPHVL ESVRSDAHLCELRLNLSKAPTFFSDGADQSNQWSICEDFSEERQVSEAFI--GGLIPHIL E-------NNELRISLSHQPKFFFNGVNASNQWSICDDFSEDQQVSLAYCNEGGSIPHVL NGNTSSDDISEIRLNLCQKPKFFFNGSNTNNQWSICDDFSEGQQVSRAFAQSLSSVPHVL KSTGLITNSNELRVNLCHQPKFFFNGVNSTNQWSICDDFSEGQQVSQAYTSHSPSIPHVI NLEN----SSEIRLNLNFQPKFFFNNDSTQNQWSICDDFSEGQQVSQAYTKVYDGIPHVL E-------NNEMRLNLARKPKFFFNGVNALNQWSICDDFSEGQQVSSAFYAPGGTTPHVL E-------NSELRVSLTHQPKFFFNGINSANQWSICDDFSEGQQVSQAYTSEGGTIPHVL G-------SNELRLSLSAPPKFFFNNVNSANQWSICDDFSEDQQVSTAYCNDGGTIPHVL SDTK----LGELKLSLSRSPNFFLSGDYDSNQWSICEDFSEGKQVSDAFT--GGSIPHSL ------------------------------------------------------------ KGLESSLKILNSLILDYISDILHPQMHPAPHGLMAYNMAPSSTSETLHSIANGISPPGFG TGLDESLKFMNSLILDM----NSTEHFPPTTQLQHGI---------MHSMPPTSTALRFN ------------------------------------------------------------ SGLQDSLKFLNSHILEYK---STNEILPPSTITVPSH----QQSHDLMTPMQSSTGTNDS KGLQKSLRFMNSLILDYK---SSNEILPTINTAIPTA-AVPQNIAPPFLNTNADSNPNTN KGLQKSLRFMNSLILDYK---SSNEILPSINTAIPAV-ALPQNIAPPFLNTNADSNPNTN KGLQKSLRFMNSLILDYK---SSNEILPAINTAISTA-AISQNIAPPFLNTNADSNPNTN KGLQKSLRFMNSLILDYK---SSNEILPAINTAIPTA-AVPQNIAPPFLNTNADSNPNTN ERFTKFFEIYEFFDFRL------------------------------------------- TGLEASLKFMSSLILDYN-PHAQPQPHPHSHPHHSSD------------PAQVQPEPHSL NGLEDSLKFMNSLILDYN---STNQIIPPPTVTQPHA-----VSQQSMILQP-EPRPAEQ VGSTLSLQYLSQFILQHQQPHNQFDFNSQPFETIPTSFQDLPIYESISNSNHTDLKDTNA TGLESSLSFMCSSIQDHN-----SGAHVLSHKSHLRD-----------------SVGAPE VGVKNSLQFLNSFILENNIPHRSSNFHPHIQLSDPNNFTTKETVWNSSDRSPGDSNPSPN VGNTSSLQYLSQFILQHQQSQNQFEFNSQSFDTIPTSFQELPIYESISNNNQTDSKDSNK VGGRSALTYLSSYINANNPPPPAPAAAAQSSTAVPTSHNSLDSTGLSATALELSLWQNHN VGSTRALQFLSNYISHYQ--QQQLHQSPPVYESIPTNANPLDENDKDYDLESIDPQGSIN VGAKNSLQFLNNYILSNQRADGLPNNMIHSQNHNDDYYASKGTLIANFEDTSSGSHESPG VGIKSSLQYLNSFIADNNFPTSMSGFSPLADFNSDTSPNSIGTNSNQINVKNSTPALQQH VGVKSTLQFLHAYILELNLPHHPPRYHTDLHLVDIQD---------------DHESGNFQ KGIQDSLKFMNSLILDYN--STTHERIQQHPINLNNE------------IPNGGTESGDS ------------------------------------------------------------ GPYAALPHIQPQSTYFFNYNPQPVAHEHMSGPSTYD--------GHTILQHPPAIQANHN DDPNLIA----------------------------------------------------- ------------------------------------------------------------ LLPNIISP----------PNTNTLFSLLPDQN---------------------------- LEDSLF----------FDHDLLSSSITNNNGQ------------GSNNGRQASK------ LEDSLF----------FDHDLLSSSITNNNGP------------NSNNERQGSK------ LEDSLF----------FDHDLLSSSITNNNGS------------NSNNGRQGSK------ LEDSLF----------FDHDLLSSSITNNNGP------------SSINGHHGSK------ ------------------------------------------------------------ AQSAFFRN----------YGPHSTDDILIQDPDQYEAQTANTEF---------------- GQQQFFDDFDAQAILGLPHQEHDQLTTQ-------------------------------- TTTTTNKHTPSSVTYTNNYNESPFSIASTNNNLFYESESASTNSAMKKMNSETKGNVSSN AHNIVINPEPHA----LGTRQQPFF-------DDFNHQDIYAI-GEHNTPQ--------- SMTSSNNPQSNLTNHSQENQNYPYNDMFGNTP------DFFTTGQASENPIMHNTDRNSN HTPSSTTFTPQNATYTNFYNESPFSIASATTILFYESESASTNSSIKKLNSETKGNVSSN LTADPKTLASTA---NFNINQSPYSTTSSQQYYQLETPQLMQSFNSNSNSNIIKTNVSNL NTPTTFTPQQPQ------VSTAPVTTGTTTGTTNTTTTNFNESPSINSMNQYYENSPDNS VIKSRYNEEKQMSSLGVNPERKEYEEMFATTP------DFFNTVTPNSNFLPHVGSHFIN HLLQLFSNTPDFTTLSGDGGQTPSNM------LNHESPSMNSQGGVNSNTISIHQNNNHN INTESLDVWQDKSPLGVDSRTSPASGTSRS--HDMAVAPLVASG-----------ENYNM HFGNSF--------FFEEHDPHQLLNTNNTND---------------------------- ------------------------------------------------------------ PIINSA-------YAHNPMDNMLVGVPSVNNSE---SMLTFTNESGMTNN---------- -------------HDTSANPSHNSQSSFLTT-----------NDNFTSMTNFSSNIPKT- ------------------------------------------------------------ ------SDSNLLNHETDNLLPNSNSQQHQNESEPS-NFF--------------------- ------DDTLNLLTTVNSNNNHNAEENHLAQEHLSNDIVANPNDHLLSLP-TDSELPNT- ------DDTLNLLTTVNNNNNHNAEDSHLAQEHLPNDIVANSNDHLLSLP-TDSELPNT- ------DDTLNLLSTVNSSNNHNAEENHLTHEHLSNDIVANPNDHLLSLP-TDSELPNT- ------DDTLNLLTTVNSNNSHNAEENRLAQERLSNDIVANPNDHLLSLP-TDGELPNT- ------------------------------------------------------------ -------------STAAGSHFLTA---HLADTQIP------------------------- -------------QFVSPNSAQSH---HFTDDNNT-------VSQANLLPNQEAQIPNT- SSTNGPDDDNNLFFTTTETSPEDDIIGMFTSQAHENSSYTHINNGSLTKSGLSETSNNNN -------------FAASNTTTQSH---SFSQHSPE----PSGNEH------TSPQYSESG DNKENNDDDENLISPSTNLQSYTH-----EHHSPFADVHSSSNDQPFDFTIGNDFSTNDN SSTNGPDDDNNLFFTTTETSPDDDILGMFTDQTQENSSYTHIKNGSLTKSGFNETNNNNN NSAVGSIKTASTSSFHEQVVVNTHGKPAYTHTSEFGLEFTTDFNFAIGLGREHDREREND LKKMNSNNDAALFFNTTETSPVDDEQQSQQQQQPQ-ASYTHVRSNSGELSRLSDAFINKQ SPSMGIYENDSQLHSRQENVDIHRPENEYNQGSHDDGYHPQQVEHHYDFE-SNDFHPNE- DFLDSI-------QTFPSSHDFEFGGDLASNGETP---LGGAFDGAPNGGAGNNNSSNNN EYRDQNFDEE---SDLHPSNSNNEASPSASLENLP-HNPGLDSHQPENFAVDNEYIPE-- -------------GTYNFINNNTHNHPHLNIVQHQ-------DDHGTGFP-MSHDIPLVN ------------------------------------------------------------ IPEFLRNPSEVNEDNRWI-----------MIEVIDF-EPDHIECQEHERFIYLYDSTYHH -PDFLNSTNLQEGQSMSTLLFQDQHPNTITVNTVKNPHEQTVPLLENEQFIYIKDQKRHT ---------------------------SVGVKIPDF-PPTYIKLDQNEKFIYITSKTNCE ------FENYDQETGKWL------------------------------------------ -PDFLKNTNELTDEHRWI---------HVTVQIQSA-PPSYIKLEANEKFVYITSTMNGL -PDFLKNTNELTDEHRWI---------TVAVQIQDV-PPSYIKLDKNEKFVYITSETNGV -PDFLKNTNELTDEHRWI------------------------------------------ -PDFLKNTNELTDEHRWI---------YVGVQIQDA-PPSYIKLDPNEKFVYITSTMNGL ---------------------------KVSYRVVAE-PPSHIKLGNNEQFVYIKHKQFHK TPEFLNHTDLHNDDQHGLNNLLNFNDQEVACRVAENPHEEVSPLSETEQFVYLTHSAYHR -PEFLSTTDLTSEDHNGISDLLTFESQLITCRVLNT-NPLLKP---NELFLNLKHNQFHT FGDIDFQKNDNNNGNTNLDSFIDFEN----MTVSKYHPPT------------PREVEVTL TPDFLRHAEMGVEEQSGLNNLLIFDDHMVQQDTVDTTVIKKQESAPNERFLYLKHAEFHN ------PPSNASSSSNQVDSFIDYNSG-MTVSV-------------------PREIEVTL FGDFDFHQQNDNNGNTNLDSFIDFEN----MTASKYHPPT------------PREVEVTL VPASS-QTQPLDLHQTMTVDFIDFNA--MTVEIQEKYKPQV-----------PREVEVRL FDEFGDFVQEFDSNNQNFDSFIDFGN----MANTKYNPPI------------PREIEVTV SPALSNGTPNTASSNAHVDNFIDFNAH---MRIVDRGPSIPLLFPPKHNMDIPKEIEVRF ------NNATSGGTSSNVDSFIDFGSH-------MSYDPIPV----------PKEIQVTI ------ETPPEDHSTGGVDSFIDYNAK-------------------------SKEFEVNI -PEFLKQHENLNSNNKWF---------GITCTFVET-PPSYIKLEPNEEFLYIKNSKYHL -----------------------------HSPAPPTSPPTTTPTLAVEPYLSTPSNRSTM SRGIACIVASPKRHR-----------AKNKLIVLVHGSLSHKNAIYQPLLAHCLAELGYH GVGLAAILSKPPSLQERVKNEFKFAFPTHKLVLLLHGHQSFKNALYQPLLADKLSKNGYY SYQIAAIITYPDKKGSVGLETGKPRNANNKLALLLHGSQSHKSAIYQTLLAKRLAQSGYW ------------------------------------------------------------ SYQIAAIVSYPEKRNTANKEDGKLLCKENKLALLLHGSQSHKNAIYQTLLAKRLAEFGYW PHRIAAIISYPERRDNVNIEDGKSQRKSNELALLLHGSQSHKNAIYQASLAKSLVQSARW ------------------------------------------------------------ SYRIAAIISYPEKRNTPNIEDGRLLYKDNKLALLLHGSQSHKNAIYQTLLAKKLAQSGYW AEGVAGILSHPKSMQDRLKHEDQFALPQHRLVLLVHGHQAHKNSNYQPILASRLTDLGFY ERGIAGILTKPYSLRERLVNESTYALPLHKLVLLLHGNRSHKNSNFQPHLAERLSQEGYY GIGIAGILTKPFSTTEQVANQAEYALPTHKLVLLVHGHSAHKNGVYNQMLAAKLAEMGYY GKGVTGTLAIPLAFDSENPFEEGLVPVTHKAALILHGQGGHRNYCYQKTLAHRLAELGIF STGIAGILTIPTSLQERIVNERQYGFPQHKLVLLVHGHSAHKNTVYMPLLAQRLAEMGYY GKGVSGTLTVPHSADSESPFEQNYAPTTNKAAIILHGQGGHRSYCYQKMLAHKLADLGIY GKGVTGTLAIPLAFDSDNPFEEGLVPVTHKAALILHGQGGHRNYCYQKTLAHRLAELGIF GKGVAGTLAIPHAFEAENPFEDNLVPATHKVALILHGQGGHRNYVYQKHLAHRLADLGML GKGVAATLAIPPGLDSQNAFAENLAPATHKAALILHGQGGHRNYCYQKTLAHRLAELGIF GKGVTGTLAFPHAETDPNYLQKGYAPATTKIALLLHGQGGHRDYCYQKMLAHKLAELGMY GKGISGTIAIPHSAEAENPYEDGYAPATHKAALILHGQGGHRDYCYQKRLAHKLADLGIY -KGVSGTFAVPPSVDNPNHLAEGEAPASKRAVLILHGQSGHRNYCYQRDLAEALGQLGLY ENGIACILTYPSSLKERIKHENIHNLANHRFVLLLHGMQSHKNAVYQPLLASKLSDLGYF GAELAGILNEPPSAV-DNPNFKTIFPP--KVVLILHGQGGHKDYCYQRMLGQELPENGMW SLRLDFRGLGDSEDVRDPKLGRTIEEDIHDIKTVYKATQEAQICANLFSITFHAIVGHSR VLRIDFRGLGDSEDNRVPELGRTIQQDVEDLTTIYEFVSSDACKSLLGALTLDTIIAHSR VLRIDFRGQGDSSNNFDAAIGRTLDQDLEDISVVYQTMLDRSVREQLYTISLGVIVAHSR ------------------------------------------------------------ VLRIDFRGQGDSSDNCDPGLGRTLAQDLEDLSTVYQTVSDRSLRVQLYTISLDVVVAHSR VLRIDFRGQGDSSDNYDPAIGRTLDQDLEDLNTVYQTILDRSLREQLYTISLDVIVAHSR ------------------------------------------------------------ VIRIDFRGQGDSSDNYDPALGRTLDQDLEDMSTVYQTVSDRSLRELLYKISLDVIVAHSR ALRIDFRGLGDSEDSKDSKIGRTVVQDTEDIETICELVSDENLSNELFPVTLDAIVAHSR VLRIDFRGLGDSEDCGNPAVGRTLEQDVEDISTVYEFAASDACVELVGALTLDTIVAHSR VLRIDFRSLGDSEPNADPSIGRTIQQDVQDIETVYQFACSEQCRQLLGRLTLDTIVAHSR SLRIDFRGCGNSADNANELEGRTLTQDVEDIQSSADFIRDGKLNGTGIDLTLSSIISHSR VLRIDFRNMGDSEENRDPAQGRTIAQDCEDLETVFQFASSENCKQLVGALVLDTIVAHSR SLRIDFRGCGNSADNADEKIARIIGQDIEDIQASAEFLLDSKQNPLGMRFMVSSIIGHSR SLRIDFRGCGNSADNANELEGRTLTQDVEDIQSSVEFICDGKLNGTGIDLTLSSIISHSR SLRIDFRGCGDSADNADAKEGRALLQDVEDIQAAAEFIKSGELNGLGIDLTLSAVISHSR SLRIDFRGCGNSAENENELEGRTLAQDVDDIQACAEFLTDGKLNGLGIDLTLSSVISHSR SLRIDFRGCGWSDENADPNVGRILEQDVEDIQAAVDYVTDGTRNEAKTNFLLSAMIAHSR SLRIDFRGCGSSAENEDAQKGRVLAQDVDDIQACAEFLRDGKLNPLGMSFTLLSIIGHSR TLRIDFRGCGSSADNDDPFLGRTLDQDMEDIQACAEYLVSGN-NEVGIKFSIASIVSHSR TLRLDFRGNGDSEPCSHNKTGRNINIDLEDIGTIYSFIKNSK----IFSLSFDTIVAHSR TFRLDFRGCGESTEDDHHKLKRTIKRDAEDIEAAVTWLQKR-------GLTVCALVAHSR GVLAMFDFALSIA--PSIIPILVNCSGRFDGQGLLKRCSENNPNWIEKGGFYATTLRQGK GVISMFEFARSF-----YVPNLINCCGRFDSQGLLLKAARRCPQWEEDGGFYCNTLRFGK GSLAMFKFCLKLLSMACPLPHLINCAGRYDGRGLIERCSRLHPNWEREGGFWANGPRYGE ------------------------------------------------------------ GSLAMFKFCLKLHAAESPLPHLINCAGRYDGRGLIERCTRLHPHWQAEGGFWANGPRNGE GSLAMFKFCLDLLSKAFPLPHLINCAGRYDGRGLIERCTRLHPSWEKDGGFWANGARYGE ------------------------------------------------------------ GSLAMFKFCLKLLATASPLPHLINCAGRYDGKGLIERCTRLHPHWQTEGGFWANGPRNGE GVIAMLEFCRRHP--ERYIPNLINCSGRYDGKGIIQKRLKYSPNWKKDGGFYCDLPRHGG GVLSMFEFALRH-----PVRNLVNCCGRFEATGWLERVMRTYPNFSADKGIPCVALRHGE GVIAMLEFAMTR-----YIPNLINCAGRFVSHELYTKAKRRNPNWEKDGGFYCNAVRHGQ GGVAMFLWAQIQDQLAIIVPNLVNCSARFTSPTVLDR----YAGLEGL-DFIVTTYRRGS GVMSMFEFARRR-----FVPNLINACGRFDSSGLIEKSRRRNPNWERDGGFTCEMLRHGR GGVAMFLWALEQDKIAIVVPNLVNCSARYRSDTVYDR----YPDFE---GAYLRSLRYGE GGVAMFLWAQIQDKLAIIVPNLVNCSARFTSPTVLDR----YAGLEGL-DFVVTTYRHGS GGVAMFLWALEQDALAIIVPNLINCAARYTSKTVLER----YSAFVDY-DYIVTTFRYGK GAVAMFLWAQIQDKLAIVVPNLINCSSRFTSPTVLDR----YSSFADM-DFVVTTFRHGE GAVAMFLWACEQQKLAVVVPNLINCSSRFRSHTIRSR----YHLDDQDVEYVQKALRFGK GSVAMFLWAMLQDEYAIIVPNLINCSGRFSLPTVADR----YPLHDEFFKEVMMCLRHGQ GSTAMLLWALSQSEPPVKVESLVNCSSRFDSAAIAKR----FPLFDLSFDMMQYCLRHGK SVISMFQFLIENP--TIYIPNLINCSGRFDGLTLLERLQNKHPHLEKENGFWCTLLRYGE GCLAAMEWFHNGINANTVLPAFVNCSGRYKTHEIWDKLREGYGTWKEHKQYRSVENFEGK LQKIWIPKEESFSVIRTNTLNYRNLSHDTTVISIYGTNDEVVPPMEASDYSSVFKDHHQL WQDVWIPRQETLSAGTLDTSKFEEINSETWILSVYTATDPVIPIASAAGYSNLFEGRHTL YKDFWIPSSETYSIANVCVPEFAKIPPNCSVMSCYGTCDHIVPLSAASNYAKLFEGRHTL ------------------------------------------------------------ YKDFWIPLSETYSIAGVCVPEFATIPQTCSVMSCYGMCDHIVPISAASNYARLFEGRHSL YKDFWIPSSETCSIANVCVPEFSATPPTCSIMSCYGTCDHIVPVSAASQYAELFKGRHSL ------------------------------------------------------------ YKDFWIPLSETYSIASVCVPEFAAIPLNCSVMSCYGTCDHIVPVSAASRYAKLFEGRHSL VSKVWIPHSETLSAVECPSHAFGSINQMTSIMSCYGTCEEIIPLSAVASYSNXFQGRHHL RQEIWLPEPEVLSVATTQIDRYANIDVQTWVVSIYGTADAVIPLTAAGNFANMFRGRHTL LKKTFIPKSETASAADVDTLKFKQIDQRSFVLSVYGSRDDVIPLSASAKYSNLFQGRHTL YQQINLSAREIISLSKPDLSKLTDLSRDWSVLSVYGTEDEIIPKYDSANFANALNLSHTL MQQMWIPKPETMSAATVDSSKFAEIDSRSWVMSIYGSNDSVIPLDALAQYSNLFEGRHTA IQKVFVSKDEIDSLAAPDMSALRDLSTDFSVLSVYGLEDRIIPVNDGSFYANVLNYSHHL YQQVNLSAREVISLSKPDLSKLTELSRDWSVLSVYGTEDEIIPKYDSANFANALNLSHTL YIKHDLSAREIITLSKPDFSLLTSLSRDWSCLSIYGLEDAIIPRYDSANFANALNLSHTL YKQIQLSAREIISLSKPDLTSLNELSRDWSVLSIYGTEDEIIPKYDCANFANTLNFSHTL YADTRVPRLEIRSLANVDLSHIGQLSTEWSVLSVYGTEDHIISKEDCAYFANTLNYSHHL MSEILIPKSELVSLSKPDLSKLHGLTTEWSVLSIYGLEDEIIPINDSSLYANALNFSHRL WQEVMVTRHELLSQAQTEMEDLKYLDPSVPVLSIYGLEDRVLEPTDPSGMANALSGTHNI IVNSWIPLDEMLSFINTDSKEFDKINNNCWVLSCYGSKEQIIPLESASHFANTFIGRHCL YTKMLVSIEEPTSIANTDIPGHCKANAGGHTLTVFGSRDQVVNVEDAGHFANALQPRHHL IYIDGAGHNFYGKLGEQNTRGLPLRRGMINYNHELVEYLQDIFTKSV------------- EIVPNCDHNFYGFPDDTNKLNLPIRKGKVNYGAYLVAYLLEYLNPENQLQRFYNTHKLIK KLIENADHNYYGIEDDPNELNLPTRRGRVNYSPLVADLIMEYLNNT-------------- ------------------------------------------------------------ KLIENADHNYYGIEGDPNALGLPIRRGRVNYSPLVVDLIMEYLQDT-------------- RFIENADHNYYGIEGDPNVLNLPIRRGRVNYSPLVVDLIMEYLKNT-------------- ------------------------------------------------------------ ELIENADHNYYGIEGDPNVLNLPIRRGRVNYSPLVVDLIMEYLKNK-------------- EMIRXATHNFYC---------LP------------------------------------- EIVVGAGHDFYGLPDDENLMELPTKKGRVCYHSVLASKVVLHLRNKNQAEQFHSLNRTLE EIIMEADHNFYGFPEDRNEQGLPLRKGKVNYNFVVVDTISQYLSNERQLDRFYEASKVIR KLIPDADHNFYGELHELNPYNLPLKNGKVNYNYLVTDYIIDFLTPEMELQRFIATSRDIG DLVMYADHNFYGLPGDANVHGLPLRKGLVNYNVTVVERIASFLSHENQLTRFYETSKYIP ELIPFADHNFYGDAEDYNPHNLPLNSKKANHNVMVTSIIIDYLKPENELNRFLYRSFNVG KLIPDADHNFYGELNELNPYNLPLKNGKVNYNYLVTDYIIDFLTPEMELQRFIATSRDIG KLIPDADHNFFGDLSDVNPLNLPLKGTNVNYNFLVCDYIIEYLSPQNELERFLSSTSEIG RLIPDADHNFYGEMSEINPYDLPLKGGKVNYNFLVTDYIIEYLSPAKELERFISTSKDIG ELIDGADHNFYGDKEDYNPLNLPLTKKNVNYNYLVSAIVAKYLRYDQEIMRFNARSKTIG ELIPKADHNFYGHNIEQNPENLPLNKKQVNYNFKVIDIIANFLSPENELQRFLHTSLEIG YLIPDADHNFQGDAEEYNPDNLPLNRKKVNYNSVVVEHILNYLGPDARAQRSSELCGNVS QIIDGADHNFYGLPDDQNLSNLPLRKGKVNYGVLLTSKIIDHLSWQHQLERFYKITEYID SIIRDADHNFYGDELPAEKGAEPGKRPKVNYNPRVTKIIIDWLKSEAFHARALNDMATIG ------------------------------------------------------------ SNFEVENLSFNNNMTLSPEEMAKHYQGMFLSSYNFPQAYEIVLEAIVFHCSAGKDRTGIL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IPIPVCSVPFNKNMSMSPEEVARHYQDIFISTHNIPAAYEGILEAAIFHCAVGKDRTGIL STIQVENLAFNKSKNLSPDKIAKHYQGLLISSYKFPQAYMIVTKAVVFHCTAGKDRTGIL RVIERIHSPVFSNDDYSPQTIAIRYTNLMTCWSTYVNVYEDMLEPFVFHCTAGKDRTGML DAIPVQNLAFNQNQSAAPEDMAQLYRGLLLSAYMFPQAYQVMLRAAVFHCAAGKDRTGIL YIIKRIHAPVFSETDYSPEVIAIRYTNLMTSWFTYVNVYEDILESFVFHCTAGKDRTGVL RVIKRIHAPVFSNDDYSPQAIAVRYTNLMTCWSTYVNVYEDMLEPFVFHCTAGKDRTGML SVIERIHAPVYSNDDYSPQAIAIRYTNLMTSWSTYVNVYEDMLEPFLFHCTAGKDRTGIL RVIKRIHAPVFTNDDYSPQAIAIRYTNLMTCWSTYVNVYEDMLEPFVFHCTAGKDRTGIL CVVKRVHAPVFRHEDYSPDQIALRFANLTISWHTYVHVYDHMLSPFLFHCTAGKDRTGVF RLIKRIHAPVFSKDDYSPHAIAIRYTNLMTSWNTYVHVYENMLEPFVFHCTAGKDRTGIL TIITRVHAPVYANDNFSPEAIAMRYSNLMSSWHTFVKVYQDMLKSFVVHCSAGKDRTGII VNMKVEKLPFNKNVSMSPDMMAEHFQSLLISAQSFPKTYMIILKAVMYHCTAGKDRTGIL TVTERVHTPVFKSKDLSPEALAERYRNFLDPIEGFKRAYDEILTPMIVHCTAGKDRTGVF ---------------------------------SMWLPLAE--VSAERMKLAEVQFEAMQ GMLILGLAGVDADTISHDYELTKLGLTTEKRLISLFLPYSAQTVDEEKIGIAKVQFDAMN -------------------------------------------MSQEKVDVAGVQFDAMC ---------------------------------MFLNFGGQE-VSQEKIDVAGVQFDAMC ---------------------------------SFFLSLRQE-VSQEKLDVAGVQFDAMC ---------------------------------SLFLSLRQE-VSQEKLDVAGVQFDAMC ---------------------------------SLFLALKQE-VSQEKLDVAGVQFDAMC ---------------------------------SFFLSLRQE-VSQEKLDVAGVQFDAMC ------------------------------------------------------------ AMLVLGLLGVDADTIAHEYELTTIGITTEKKIYSLFVPYGAQELNQARLDVAEVQLDAMT GMLILGILGVDEDTIAREYELTTIGLLTEAKLISLFLPY-QK-VDQSKLNMAKGHFNAMG GMLILLLAGVDRNTIAKEYELTTVGLRPDHPVLSVFLSSASQAIDPEKIKLADIQFSAMA AMLILGLLGVNDDTIARDYELTTLGLETEETLISMFLPFSTQEVDEQKLELAQVQFDAMS SMLILLFLGVDKHTISKEYELTTVGLKNDHASISFFIGSSSQAVDPEKIKLAEIQFTAMS GMLILLLAGVDKNTIAKEYELTTVGLKPDHPVLSVFLSSASQAVDPEKIKLADIQFLAMA GMLILLLAGVDKDTIGKEYELTTIGLKPDHPVLSLFLSSSSYAVDPEKIRLATIQFQAMA GMLILLLSGVDKNTIAKEYELTTVGLKPDHPILSVFLSTSSKAIDPEKIKIAEIQFEAMA AMLLLRLVGVDRHTIIKEYELTTLGLKPDHEDLSFFLNTSSYAVDPEKVKLAEIQFSVMS GMLILLLLGVDKNTIAKEYELTTIGLRPDHPQLSLFMNSSSYAVDPEKVKMAEIQFTATA VMLMLLLTGLDKNTIAQEYELTTIGLKPDHERISFFLNTSSNSVDETKIQLAKIQHEAMS TMLILSILGVEDDLIAKEYELTTIGLKTEEKLYSYFFPSGE--VSEERLKVAEVQFDAMN CALVLRLLGLDHDTISREYELTTFGLREAVPRL--------------------------- TTFNNIMETCRKKCIPRGFSESDLTKGEMTCVDRCVAKMHYSNRVIGAYVQTQRFSPERQ TTFNTMLRTCLEKCIPHEYGESDLNKGEMCCIDRCVAKIHLSNRLIGGFAQSRGFTPERH STFNNILRTCLEKCIPHGYSESELTKGEMCCIDRCVAKMHYSNRLIGGFVQTRGFGPENQ TTFNNILKTCMEKCIPHGYSEGDLTKGEMCCIDRCVIKMHYSNRLIGGFVQTRGFGPVNY STFNNILSTCLEKCIPHGFGEPDLTKGEQCCIDRCVAKMHYSNRLIGGFVQTRGFGPENQ STFNTILRTCLEKCIPHGYSEPDLAKGEQCCIDRCVAKMHYSNRLIGGFVQTRGFGPENQ STFNTILRTCLEKCIPHGFGEPDLTKGEQCCIDRCVAKMHYSNRLIGAFVQTRGFGPENQ STFNNILSTCLEKCIPHGFGEPDLTKGEQCCIDRCVAKMHYSNRLIGGFVQTRGFGPENQ ------------------------------------------------------------ TTFNTLLAACREKCVPHGYGEPDLTRAELSCADRCIAKAHAANRAIGTYVQARGLAPHRA TTFNTMLRSCLEKCIPHEYGESELNKGEMTCIDRCVGKIHYSNRLIGGFVQSRGFGPESH FTFNKLLRRCEQKCLLREYGEGELTKGEQECIDRCVSKYVKANVIIGEHLQKQRLDPFNS TSFNTMLRGCLEKCIPHEYGEADLNKGEMTCVDRCVAKIHFANRLVGGLAQARNVGPD-H TTFGKVLDTCRNKCIPAEYGESELNTGEQCCIDRCVAKYVKANAFIGTNIERKGFNPNYS FTFNKLLQRCESKCLLHEYGESELTKGEQECIDRCVSKYIKANVIIGEHLQKQRMDPYNA ATFNKVLSTCEAKCLVHEYGEGELTKGELECIDRCVSKYVKANKVVGEQIQSQRVDPYNR FTFNKLLRRCESKCLLHHYGEGELTKGEQECIDRCVSKYLKANVFMGDYLQKNRFNPYNS ATFNRVLASCEKKCLAHEYGEGEINTGEASCIDRCVAKYVKANAFVGEKMRSQ-LSPESM KTFNNIIKTCEKKCLPHEYGEGELNTGENCCIDRCVAKYVKANYLVGSNFQEKNINPYTN LTFNSMLDTCKEKCIAHEYGESDLNTGEMCCVDRCVAKYVKANLEVGTALQSKGFTPEGI QTFNNILKGCLEKCIPHGYGETELNKGEMECIDRCVAKLHYSNRLIGAYAQTQGFGPEKY ------------------------------------------------------------ LLVMDVDLDFADGQSPMRTKKANADKFPKESSPLVFKLGNNLYPVPLSTSDFSENFINYI LLLMDVDLDFLDGISNESDDDINEQPSAK---ELRFKYNNKLYPVRFLHLDESKEFAQYV LLLMDANMDFLDETAQTGDHMADEQPIEKDGLPLKFRLGPKLYPVKIPRLDTTKEFTTYV LLLMDVNLDFFDPSEPTEDVSITDQPLL-NGGTLNFQLGPTIYPVSLPNIDNSPEFTEYA LLLMDVDFDFLDGTAQLSNNKTDDQPIEKNGMPLKFKLGPKLYPVRIPRLDTSKEFSAYV LLLMDVDLDFLDGTVQKNDDMADHQPIKKDGVPLKFRLGPKLYPVKIPRVDTSKEFTTYV LLLMDVDLDFLDRTAQTSDYKTDNQPIERNGLPLKFRLGPKLYPVKIPRVDTSREFSAYV LLLMDVDLDFLDGTAQVSDHKIDDQPIEKNGLPLKFILGPSLYPVKIPRVDTSKEFSTYV ------------------------------------------------------------ LMLLDIDMDFVE------DEDMGQQPDL---EKLRFKFAPTLYGVQVPYVDNSKEFSQYA L----------------------------------------------------------- MKFDDIDLEIPESISSETEGISDDKEYIDNTKSLEFKFDVQKYRKGIEKSRPDEKYILYV LLLMDVDLEFLKGSASDLHTESLEQPIKERAKALKCRVAPKLYSPVFHRIDNTDNYKQFV MKFDDIELEIPDSASSETESFSDKQDYIRKSDVIEFQFDSGQYKDSLTQNDVSKSYTKYI MKFDDIDLEIPDSISSETEGISDDKEYIDNTKTLEFKFEAQKYRKGTEKARPDEKYISYI MGYVEVELDLPSESASFSSSTSEDTNYPDASEELVFCFNKDLYQQTCTPSTGFKACVEYV MKFDDIEIQLPDSISSETEGISDDNGYVDDSDSLHFKFDKDQYKRSIDIVDSDQSYIDYV PMFDDIDLEIPTTSTSQTESASPERPKTSSSTELPFQFDPDAHRRSAKHVDDAHAQNEYI MNFDDIELEIPDESTSETEAISDEKSYVDDSIPLEFKFDKKQYDQTVGISDSSQNYVKYV VPQHDIELEIPDSSISSDESETSLKNRLKETQRMEFNFDHKQYEESLTQADDSKTYTNYV LLLMDVDYNFWEVEGEDAAGEVNDEQPLNENGNFKFKMNTKLYPSKVPGYDNSREYSSYV -TINGADYISPDLTAREFGEA--PIPEGQKSRNMGFVMDPTLYPTTTRVGDESDNYKGFV CNLFDIYQDLGSHRIFSRPTIGVISSDYELEHTRVVNMALDSMIIELEILIASYLENANI SKLFELYQGLGEHRKNDVPTIGLIKQTSRLEHFSIVNLAFHALVTELEFYIESIKYTNKL SSLFEIYRDLGDDRVFNVPTIGVVNSNFAKEHNATVNLAMEAILNELEVFINSTDLNGRL SRLFEVYYQLGDHRQFSVPTIGVINKRSIGDHNQVVNLSMENIVNELRIFIENGEKDQIT SGLFEIYRDLGDDRVFNVPTIGVVNSNFAKEHNATVNLAMEAILNELEVFIGRVDQDGRV SGLFEIYRDLGDHRAFNVPTIGVVNSNFAKEHNATVNLAMEAILNELEVFINSIDQNGRL TGLFEIYRDLGDDRVFNVPTIGVVNSNFAKEHNATVNLAMEAILNELEIFINSIDQNGKL SGLFEIYRDLGDDRVFNVPTIGVVNSSFAKEHNATVNLAMEAILNELEVFISGIDQNGRL ------------------------------------------------------------ AKLFEVYKSLGADKQFAVPTIGLINHTSTLEHNQTVNLALEAIVSELELFIESLKYSGRQ ------------------------------------------------------------ NNMFKIIQKLTEDDITRFDPIGLVMKAKQVRKFKKIDEALREIIDYLQDLVNSIKEEQES ATCFEIYKNLGEDRIFSNPTMGLINNSAREEHSKAVNLAMEALVDELEVFAESQ----RL NSLFKIIEGFTNDDITRIDPIGLISSARKAQRMHKIDEAFTKIVENLTQYIHDISIGVDD NNIFKTIEKLTEDDITRFDPIGLVMRAKHVQKFQKIDEAFKQIIDYLQNLVNSIREEQES NSNFKITEELLAYKSTQIATIGLITENEKNTISRLVDDALVSVLQNLSQLIETPETDEEI NSMYKTIERLTSDDITRLDPIGLITRASQAYKFKKADESFQKIIENLQALINSAEDKHES TKLYKVVEDLGPK---PAPPLGVVANRAAVANTKRAHVAFARLLDHYAAFVDTVYVDASV NSLYKLIEGISKSDITRIEPIGFTERIDRDSVYKDIDSAFGSIVESLGVFLAEIEETVDE TSLYKVIEKLSEENVGGLPPLGVVVNSSTVHRNNVIDRAFADVVDILQVFIDKIENHEDI SKVFELYNDLDEHRVYSAPTIGIINKSYAREHNYVLNVAFESFVTELNFFIESINDPNLI AEAFAT-------------TLGPQA-------AEDLTQRFADFIESIKHYREEIRKDVDI ARILELEQCLVLQCLRTFQFIDSNDRATFFDSWTNRTDGEPKVEYIQSIFGQSDVFFTEP QRIGDLEECLSLNCLKTIYFLTDYKQEDLLESWVNRSDGEPSELVIQKIFDETLVYEQSD NRFYELEESLTLNCLRTIYFTLDQNRSKFIESWINRSDGEPDEEYIEQVFSFNDVFEIQY DRILDLEESLTLNCLQLIHFTLDEGRLKFIEEWVNRSDGEPNDSYIDQVFNISSVVETPL NRFYELEESLTLNCLRTMYFILDENRSEFIESWINRSDGEPDEEYIEQVFSVKDVFETQY NRFYELEESLTLNCWKTMYFTLDEDRPKFIESWINRSDGEPDEEYIEQVFSVKDVFETQY NRFYELEESLTLNCLRTMYFTLDENRPKFIESWINRSDGEPDEESIEQVFSVKNVFETQY NRFYELEESLTLNCLRTMYFTLDENRPKFIESWINRSDGEPDEEYIEQVFSVEDVFETQY ------------------------------------------------------------ QRLVDLEECLSLNCLKTVQFTLDNSRAKFIDSWVNRTDGEPSEAVIAKVLGDGKILENPY ------------------------------------------------------------ YDSQCLQHVLYLECFEANNFYFDQQKPELIIKWVNTFDPKPDPELLNDVIVNTPPYLHPR ARAAELEECLALNCSNAIHYTTDDTQSGTLRQWINRADGEPSEQVIENVFSGSTPYKRLN ETTEQFYYLLSLDCLHANYFCSDRMKPESIAKWINRFDYKPDKELVESVMVNSPPYTHPQ YDFQCLQHVLYLECFEANNFYFDQQKPELIIKWVNTFDPKPDPELLNDVMVNTPPYLHPQ AENEKLQDAVVLKCFESTFFNTMRTKPEIIMEWVNRFDPQPPTEIVNEVVVNEPSYLHPL IEFQNLQHTLYLQCLKANNFYFDRRKPELILAWVNTFDPKPDSSLLNDVMVNNPPYTHPQ ARDYDLLQSL-LEALHASSFAPEQTRPELVVRWINRYDPKPDNALVDAVMYNTPPYTHAS SYLLQLHSLLYLQCLQSNYFVSDKLKPELLAKWVNGFYHKPTNELTEAVMINTPPYTHPQ TSFYRISN---LDCLQAIHFSSSQQVPELVSKWINKYEMKPENELVESIMLKTRPYSHPQ NRVLQLEESITLNCLKTIHFTFDDSREQFVNSWVNRSDGEPKEEYIEQIFTRNDVFNTLQ VEAEPLDDAYSALCIYAVYFHNGAGQSGFFGSWVNVSEQQPSVELGKEVMSQTPPVQHKD FWKLVYQLLLRGLTEQAINTLEKSELKYLKENCETTSTIFEDFIQLVKNYPLESEEHFRE FWDLTAQLLLRGLWSQSIQCIQNSQLEHGNETVGVF---VTDLITIIESYPLHSENLFRE FWKLINQLVLRGLLPQAIGCIERSDLSYLEETCAVSFDAIGDSVELLKQYPRDSSSTFRE FWKLLNQLLLRGLFEQAIACIERSEITYLDTECSVSASIIRDIISLLGIYPRDSSTTFRE FWKLLNQLVLRGLLSQAIGCIERSDLPYLSDTCAVSFDAVSDSIELLKQYPKDSSSTFRE FWKLLNQLVLRGLLPQAIGCIERSHITYLNDTCAVSFDAIGDSVELLKQYPRDSSNTFRE FWKLLNQLVLRGLLPQAIGCIERSDLPYLNETCAVSFDAIGDSIELLKQYPRDSSSTFRE FWKLLNQLVLRGLLPQAIGCIERSDLPYLNDTCAVSFDAVSDSVELLKQYPKDSSSTFRE ------------------------------------------------------------ FWRLLCQLIIRGLFDQAVAAIEKSELSYLADKCSATHTMVQDMVNLLQGYPRELEPVYRE ------------------------------------------------------------ FWNCISQLLTRGLFTQIHEVIEHSQYQELKEKCPELYAVIGDMDTLLSNYSYSSKGQFTA FWKLVNQLLLRGFFEQAIGALKRSLLDYLKQECDVSFGVVTDAISLLEQYPYSMGESFRE FWNYLSQLITRGLLTQAIAAIEKSQYEELEENAPELFSVIQDFSMLLKNYSMSMKHQFHE FWNCISQLLTRGLFTQIHEVIEHSQYHELKEKCPELHAVIGDMDTLLSNYSYSSKGQFTA FWKIISKLAMRGLFKQLDEILQHSDYKELEELCNPLFTAIEDFRNLMSMYSYALNGQFAR FWNCLSQLIIRGLFEQVSEVIAHSGYQELEQSCPELFLMINDMNIMLSDYSSASKGNFAQ FWSYVTALVTRGLFAQAASSLRASKFDELEHTCPVLHAQFGDLAALVASYPMAQKGQFAA FWNYLSQLVSRGLLSQAVEAITHSQYEQLEAEVPELYSVISDLVLLLGNYPLCLKGLFSE FWNYLAQLLTRGLVQQAFEALSNSGYEELKESQSQVYDLIKDFETLLGSYSMALKGQFAQ FWKLVNKLLLRGLFEQALGCLERSKIDFLKSQCEVSANILGDAIALLEQYPIDSSETFRE FWKYIYQLVCRGMLKQASHCLHNSGAGEVDPSCQET---LEQTIDILSRYPGNVSFYFRQ WKSFALELQQNFEDADKIPVPLRKNLLDAISITAGNRDKILQHSSFWYESLTGFLLYYIP WKNSVLQLMTNWDEQE-VEPEIKKNLMNIFMILSGSKNKICEFSQYWYESYCGLMLYYIP WKNLVLKLGQAFGSSANISGELRDYIEDFLLVIGGNQRKILQYSRTWYESFCGFLLYYIP WKSLALELVNNFANSDNVSGELRDYIEDVLLVISGNQNKILHYSKTWYESYCGLMLYYIP WKNLVLKLSQAFGSSADISGELRDYIEDFLLVIGGNQRKILQYSRTWYESFCGFLLYYIP WKNLVLKLGQAFGGSATISGELRDYIEDFLLVMGGNQRKILQYSRTWYESFCGFLLYYIP WKNLVLKLVQAFGSSADISGELRDYIEDFLLLIGGNQRKILQYSRTWYESFCGFLLYYIP WKNLVLKLGQAFGSSADISGELRDYIEDFLLVMGGNQRKILQYSRTWYESFCGFLLYYIP ------------------------------------------------------------ WKDLVLQLHLNWSQSEKISIELASSLEDCLLIMCGNKSKIIYYSKTWYECYCGLMLYYIP ------------------------------------------------------------ WKLLACEFRDSLSSVRTKHKLIIDQIYDLACIFTGLPKTISSYCDTWYEVYLALSLYQVD WKAVTLKLSQFYEGSVSLDSELRDLIADMVLVMSGSQSKIVQYSKTWYESFCGLTLFYIP WKLSCCEFRDLFLKFKSKDLIILNQIYDLLCILTGLPKTIAIHCDKWYEIYTALSLYQVD WKLLACEFRDSLSSVRTNYKLIIDQIYDLACIFTGLPKTISSYCDTWYEVYLALSLYQID WKLLACEYRDSLADVKPKYQIILSQLFDIACLISGMEKTIAAHSENWYDMYLALSLYQID WKVIACEYRDSLSGERPAHKLMVSQIYDLACIFTGLPKTISSYCDSWYEMYLALSLYQID WKRAASDFRAALATADAEHAAAAASIRDVAGVLCGLVRTIAAHTSTWYDMYGALALFHVE WKLAACEFRDSLAKVSPQHTIMLSQIYDVASIMTGLSKTIAAHCETWYEVYVALALYKID WKLSSCETRDLAPRVKSSLRQTVSQIYDLLCIITGLPKTIASYCDSWYEIFTALAFFQVR WKFMVLGLQQTYSNSNKITGELRDYIEDTLLLIGGNQSKLLQYSSTWYEAYASFYLYYIP WHNSISTVQSKLLKIN--DAKIQKGLTTLLQVLAGDEDAIMGTNHTWYDALVTQQQY-VP SEELIQEYVGLAVSKTPIDVTNPWETACLKILQNDIFPVLPILESLDNCTASFSAALCES TLELSQEYGQLATKHNAIDVCNNWETPCYHIINDKVADVLPILESLDLATAAFVAVLCEA SLELSTEYLEISLKSNAVDVTNNWEQSCVDIISGKIHFILPVMESLDSCTAAFTAMICEA SLELSQEYLTMSLKINPLDITNNWEKACADIINGNISSILPTLESLDTCTAAFTAAICEA SLELSAEYLQMSLEANVVDITNDWEQPCVDIISGKIHSILPVMESLDSCTAAFTAMICEA SLELSAEYLQVSLESNAVDVTNDWEQSCVDIIGGKIHSILPVMESLDSCTAAFTAMICEA SLELSAEYLQISLEANAVDVTNDWEQSCVDIISGKIHSILPVMESLDSCTAAFTAMICEA SLELSAEYLQISLESNAVDVTNDWEQSCVDIISGKIHSILPVMESLDSCTAAFTAMICEA ------------------------------------------------------------ SLQLSEEYLQLVLKEHPLDVTSPWEQACVSIITGKIYSILPVLDSLDSCTAAFTAAICEA ------------------------------------------------------------ SNEVYIDYFKTAVSEKPENLDGLTEACFLNILENNFLKVLETLHELDPPTTAYLAELMEL TLELSEEYLEISMKAHPLNVCNTWEQACASIIRGKIYAVLPLLESLDYCTAVFFSAICEA DDKLFKDYFNVAISEKPDVLSIISEQCFVNILEEKFLKMLVSVDTIDSATAAYVARLLEL SNEVYVDYFKTAVSEKPEDIDGLTEACFLNILENNYLKVLETLHELDPPTTAYLAELMEL DEEVFKYFFEASILEKPQDLDAMTEECLLNILKGNLMKALETVYYLSPATAAYLSLFMDL NDEVYDEYFKMSITEHPENFDELSESCFINILEKNYLKALETLHELDPPTAAYVSELLEL GADA--DHAELAVAEKP-----PAEAALCDAVRHRHMRLLLAIDRLDPATAAYVSRLMEW DNELYKEFYNIAILEIPSDMSQICEDCFKNILDENFLKVIKTMHDIEPATASYVSKLLEL DSALFRDYFDIATNEKPLDIDLLTEQCFVDIMEESFVKVLTTIDKLDSATAAYVSRLLEV TLELSHDYLELALSTHPLDLTKNWEQACVNIINNKIYSILPVLESLDLCTAATTAALCEA CDSRMKGYYDAAVANYPVDTFTVWEAGASHAIKGSLLLAIETLENCDSVIAALVSNMCYD KGLLYTILEENQRNGMASFLLNNFALESMKMKTLWPVAIGLISLSPYNTPSSKKSTIAEL KGIIYEIFAHKNEPTIGEFLIRQVALSSYDDKTLWPVSVGLISLSSDSGDSSKRAILAEL KGLIENVLENDYRNGMASYMLNNFAFESLGEKELWPVAIGLIALSLTGTRSAKKMVIAEL KGLLNDILNNNPNNGMATYLINNFALESHDDRDLWPISIGLIAISPGNSNSIKKATISEL KGLIENIFEGEYRNGMASYMLNSFAFESLGDKELWPVAIGLIALSATGTRSAKKMVIAEL KGLIENVFETNYKNGMASYMLNSFAFESLGNKELWPVAIGLVALSLTGTRSAKKMVIAEL KGLIENMFEGDYRNGMASYMLNSFAFESLDNKELWPVAIGLIALSVTGTRSAKKMVIAEL KGLIENVFEGDYKNGMASYMLNSFAFESLGDKELWPVAIGLIALSVTGTRSAKKMVIAEL ------------------------------------------------------------ KGLLENDLLDDLGNTMASYLLNQFALSTYEDKNLWAVAIGIIYLTPNYSDAAKRMMIAEL ------------------------------------------------------------ RFLLRGYYFDVNRRIVSEYFLTRHAYDCLNIHELVPVGIGLLLCTSNNAVSANRKVIATF KGLLENSYSMMPNNSMACYLLHGFALECYEDKNLWSVGIGMLALSPSANDSAKRLAIAEL KGLLNNYYSAINRKTISEYLLTTHAYQCLNSHYLVPVGIGLLSSSSSQSSVNNRNTISEF RLLLRGYYFDVNRRTVSEYFLTRHAYDCLNIHELVPVGIGLLLCTSNNATSTNRKVIAAF KKLLEGYYTSQ-KKTASEYFLTRHAYNNLDIHELVPVGIGLLANKRSSSKNLNLQTIASF KLVLRSYYFDSNRRSISEYFLTRHAFDCLNVHDLAPVGIGLLLCRSTNASVTNRKVIAGY HGCLDGIHDGDHGGSVSDYLLTRHAYECLEVHALAPVGVGLLASVVPSSSAHVRAVLQQF RSYLTNYYSVANKRTISEYFLTRHAFECLNIHSLVPVGIGLLLAISEQSKTHNRNVIKDF KGLLKSYYDFDTQRTISEYLLTTQAYQCLNTHDLVPVGIGLLLASSSSSIVHNRRTIESF KGILENFLDDDPVHGMASYLLNQFAFESQEEKTLWPVAIGLISISPFESASVKRTTISEV AGLLNGYGAAN-PAALPDYHLTNLALQCIGYDNLINVGIEVLQKLR--DVAPARQILSLL IPHYPFETNDDIEWALSVCAKWRLPDIAKEIYTTLGNQMLDNGNTVEAIANFSKAGQYEL LPHFPYTTNDDIEWLLSVCAKWRLPDVAKTIYKILGQDTLYQNNIVEAMSNFSKAGEYEW LPHYPFVTNDDIEWMLSICVEWRLPEIAKEIYTTLGNQMLSAHNIIESIANFSKAGKFEL LLHYPFKTNDDIEWMLSICAEWKLPEVAKTLYTILGNQMLYQGNTIEAITNFSKGGKFEL LPHYPFVTNDDIEWMLSICVEWRLPEIAKEIYTTLGNQMLSAHNIIESIANFSRAGKYEL LPHYPFVTNDDIEWMLSICVEWRLPEIAKEIYTTLGNQMLSAHNIIESIANFSKAGRFEL LPHYPFVTNDDIEWMLSICVEWRLPEIAKEIYTTLGNQMLSAHNIIESIANFSKAGRFEL LPHYPFVTNDDIEWMLSICVEWRLPEIAKEIYTTLGNQMLSAHNIIESIANFSRAGRYEL ------------------------------------------------------------ LPHYPFQTNDDIEWMLTICAKWKLPQIARTIYRVLGQEALYLNNIIEAISNFSKAGEFEW ------------------------------------------------------------ LPNYICNTNDDLEWALTICANLNLVSTARQLYYQAGLKSLEEGYMYEALNNFVNSEGMKK IPHFPFQNNDDIEWLIMLCAKWRLPEVAKTVYRILGNKLLYENNVIEAMTNFSKAGELEW LPHYECKTNDDLEWTLTICAKLNLIHTARKLYQVYGNKSLKDGYLYESLNMFVNNEGMKQ LPNYICNTNDDLEWALTICANLNLVSTARQLYYQAGLKSLKDGYIYEALNNFVNSEGMKK LPHYNVVENEDLEWALTVCADLGLTSTARDLYFQAGLQALENGYLYEALNNFVNQEGLRK LPHYYCKTNDDLEWALTICANLNLISTARELYYQAGVKSLEDGYNYEALNNFVNSEGMKK LPHYECFTNDDMEWALTLCAKFALADTASRLYLRQGEKSLRSGHVFEALSMWARAAAMAR LPHFKSLTNDDLEWALTICAQLNLLSTARELYYISGLKSLNDGYIFEALNMFVNSDGIKQ LPLYHYQTNDDLEWGLTICATLNLVHTAKELYYTYGMNSLKEGYIYEGLNMLANVKSMRE LPRFPFSTNDDIEWMLAVCAKWRLPKIAKKIYKILGSKLQAEGNVIESMTNFSKAGEFDI LPRLPYDSAREIDWAIKKCKQNGLVEVEAEILQTLAQKAIHNNNNLMGLCMFAKNGNIAA VKHYSWLLFENAAFQGKPMEDEVLSAIVDGDFNTNKVVTNAMRQSLSPYAVLSQFFSNVE VKHYSWMIFEASILQGGPLDDITINSIVNGDTDSNSMVTDVMRQTLSPYAVLYEFHKLAE VKSYSWLLFEASCMEGRKLDDPVLNAIVSNNATTNCVVTSAMRQTLAPYAILSQFYEASD VKQYSWMMFEASILQDGPLDDQILNSIVSDDHSNDSLVTNAMRQTLAPYAVLYQFFQARD VKSYSWLLFEASCMEGQKLDDPVLNAIVSKNSPADCVVTNSMRQTLAPYAVLSQFYELRD VKSYSWLLFEASCMQGRRLDDPVLNAIVGNSATTNCVVTNAMRQTLAPYAVLSQFYEASD VKSYSWLLFEASCMEGKKLDDPVLNAIVKGNTTTNCVVTNAMRQTLAPYAVLSQFYELRD VKSYSWLLFEASCMEGRKLDDPVLNAIVSKNAAADCVVTNAMRQTLAPYAVLSQFYELRD ------------------------------------------------------------ VKHYSWMIFEASILQGAPLEDEVVNSIVTGEYESEVMVTPAMKQSLSPYAVLFNFFRATE ------------------------------------------------------------ VHYIVWLIFANCLVHNRPIKDELINNIVDKKVDLNFKIHPVIQQCLAPYAVLKEFYETLP VKHYSWMIFEASAIQGAPLEDMVIDAIVSGQAETDSVLTDVMRQTLSPYAVLYQFYQQLA VHHIIWIVFQDSLVNNRPIKDELINNIICHKVDTGFEIHPVIRQCLSPYAVLVEFFKSLE VHYIVWLIFSNCLVRNRPIDDDLINNIVDKKVNTNIKMHPVIQQCLAPYAVLKEFYVTLP IHYVIWIIFTDSLVNNSPIDDELINNIVDGEI--DIQLHPIIQQSISPYAVLKEYFSSLS VHYIIWMIFADSIVNNRPVNDELINNIIDRKVDPNFKIHPVIQQCLAPYAVLKEFYSSLP IHAVCWGLFQDSLLRGAPVADELLANIVRGDV--GFAVPPVLRQCLAPYAVLAEYW--LG VHRIVWMIFQDSLVNNRPVEDDLINNIVTNNVDKSLKIHPVIRQCLSPYAVLHDFFAHLE IHRVVWIIFHEAVVSSQLFDDDLINNVVLKQTAPDFDIHPVIRQCLSPYAVFAEFLLAQK VKNQSWLLFEEAVFKGEPLDDVVLNSVITNNSNNDSLVTNAMRQTLSPYAVLYEFFQAKF LRYHCWKLFKNALVAESPVEDKSLADYVKDPASV-SDVPAEVAECIAPYAVLTEYFNLRR NERWSKALQQLMSLIEFEYLPKKYTVLLIVKYMLFDDQRMIDEETLVSLLAAIEKNWCDD NNETEKAMNHMIQLISFPYMPEQYCILLLAKFFMFTTETALDESQIFTILKTLEKI-KLN SGRWDQALFLLLLLIEFPFLPKHYLILLLAKFLIFDDKKPIDEDSAVKIIEVIEAKWETD NKDWVEANRLLIALLSFPYLPKYYLVLLVTKFLIFEGAPKIEEQDVLLIIEALENKWVED REDWGQALRLLLLLIEFPYLPKHYLVLLVAKFLIFDDKKLMDEDSVATVIEVIETKWDAD SGDWDQALHLLLLLIEFPYLPKHYLVLLLAKFLIFDDKKTIDENSVTKIIDVIETEWEND SEDWVQALHLLILLIEFPHLPKHYMVLLLAKFLIFDDKKQMDENSVTTIIEVIETKWETD REDWGQALRLLLLLIEFPYLPKHYLVLLVAKFLIFDDKKPMDEESVATVIEVIETKWEAD ------------------------------------------------------------ DGRWAEALKLLLSLIEFTYLPPQYLILLIGRFLLFDESKMFKEQDVLRVIKALEQFHRPD ------------------------------------------------------------ QRDIKLSLSKLIHLLKFNYLPKKFVPLLLAQFIPFEPNTTFQLPDLVIIIELLDNYERNE AQDLDGALLSLVSLLEFRYLPQHYAPLLIAQFLVFDDSIQIPEDTILRIIKTMDKF-NTE QSRSTTALSKLVHLIRFNHLPKKFYPLLLCQIIPFDSGMKFQLPDLIVIIELIDTFEAND QRDIKLSLSKLIHLLKFNYLPKKFVPLLLAQFIPFDPNTTFQLPDLVIIIELLDNYERNE TEKTTVELSKIIHLLKFQYMPKKFRPLLLGQFLLFRSEVELQIPDLIIMIELIDNYEVTG DKDIKVSMSKLIHLLQFNYLPKRFAPLLLAQFLPFNGENKFKLPELVVIIELIDSFECND RADTARSISRVFHLLRMRHMPRRFAPLLLAQLLMF--REHLTLPDLVVTIELIDGFEDAD SDDLSLAFSKLIHILKFNYLPKKFCPLLLCQYLPFDTNSVFQLPDLIVVIDVIDSFYATA EQKTTG-VSRLIHLLRFQHLPKKFCVVLFCQFLIL--ECDAQLPEMIMFVELIDNYYEEK AGEWEKSLQLLLALLEFEFLPKHYLLLLLTKFLLYVDNVKMDESSILRSINCINKKLCED SGQLVKSSEYLLALFEFPLLPTEYLGLLIHQLIVSSQQFNFSTSQFMTLLSAFDK-WKSQ TDSVIAYEKLSEEIPKELKSMEKLIRKKLNGKLCLNLMASLQFEQDCINAFTRRVLKEFI DSCVALYSQLRNTCPESVDSFIQDVRKTLNYKICQSFMIPMEEELAQIKRFKRQVMVKVI EKTLNLYETIIETEPDSTLEFLKSVRKKLNFKLCQTFMSVLANESSIISAFTRRIIKELI ERSQDLYSAVLEVSPEGMDKFINVVRKRLSFKLYEEFVEEQQQEKEFINAFTKRVLKEVV EKSSNLYETIIEADPSSMATLLKNLRKKLNFKLCQAFMSVLANESNIISTFTRRIIKELI EKSSNLYETIIQTDPDSTAELLKNIRKKLNFKLCQAFMSVLTNESNIISTFTRRIIKELI EKSANLYEAIIETEPDSTTELLKNLRKKLNFKLCQAFM---------------------- EKSSNLYETIIEADPSSTAGLLKNLRKKLNFKLCQGFMSVLANESNIISTFTRRIIKELI ------------------------------------------------------------ EITTAMYKELLVKVPKDPLNLINAIRTKLSLKLCHQFMLTEEEERHQILNFTKYVLSQTV --------------------------------------TDTRQEVKQITRFTKAVVRDTV KELKDLYLYSINGKPKDIDSFTRLLRNLIAAKVGKVFIMLDSFSLEVISRFKEALSAQLN EKSVALYKLLMSHGPAQLQDLEPLVRQKLSYKICQEFMSEDEESQLQIRMFLDAVMRQFT DEYTSLYKYSISSGPKDLKSLIKLLRNEVVAKIGKVYVMLDSHSLDIISRFKQSVLSKLP KELTDLYLYSINGKPKDVDLFTRMLRNQIAAKVGKVFIMLDSISLEVISRFKEALLAQIN NDKRQLFAYSVASSSPTVDDLLALLRRKVSERIAKVFIMMDSNSLEVITRFRDTVFAKLA EESKELYSYSISGKPTDVTNLIITLRNQITAKIAKVFIMLDSTSLEVISRFKQALISRLI SDSEELYQYAVERGPATVAELVHELREQIVAKIGRVYVMLDSRSLEVISRFKSAILTRTQ EELKSLYQYSINKNPTNLKELSKTIRNAIVAKIGKVYMMLDPTSLEIISRFKQAVLTRSS AESEELYHEALALGPSNGDDAIKLLRNVISTKIAELYIMLDPQSLEIISQFKQSLFQRTA DKSKKMYEVVLEKFPADLSQFSNMVRERLSIKLCQEFMKILKDEKNLTDSFSRKIIRDIV GTPAELIKDMVDKTHELVMSELRLARTSVATMSSLKGLKKQVSDACLLTRFCGSVSSPDS YPHASGVTTNRGNKLLQGRNRLDTSRPLEEEYNGSEHRLLTRKRMKFPTDDPLEEDFDEI FPEVRGETSNRGNKLLQHYSKLR--EKEHGSYNGAEHKLLSRKRMKFNNADTGDESEDGD YPEATGVSSNRGNKLLQRRRDLNNSKPIIEQYNGSEHRLLRRKRIKFTPHANESDESDEE YPQAVGITSNRGNKLLQRRLHLDSKKVDEEEYNGSEHPLLQRSIRKPSVAQEVEEEDGRY YPEATGISSNRGNKLLQRRRDLNNSKPMIEQYNGSEHRLLRRKRIKFTPDIDGSEKEDDD YPEATGISSNRGNKLLQKRRDLNNSKPIIEQYNGSEHRLLRRKRIKFTPPISGGNEEDGE ------------------------------------------------------------ YPEATGISSNRGNKLLQKRRDLNNSKPIIEQYNGSEHRLLRRKRIKFTPYIDGNEGEDDE ------------------------------------------------------------ FPSIRGETTNRGYKLYQDWRRLR--VDTLEKYSGSDHKLLARKRMKFSTDNDTSDTEEDP FPSAAGQTSNRGNKLFQSRKRLNNLVELKGGYNGSEHKLLSRKRMRFNPEEEKEEKEEDD EENESLPVYNRGLKLSKTQPSFNTLRSKVTEYGGKKYSVLLHNKRKWNEDQNEDDEDDKE FPSAGGITTNRGNKLLQSRAFLNNSAGTNREYNGSVHKLLARKRRH---EEDVSDDEQ-- GPGPEIGATSRGNKITPARTSDNSLIPKIVDYEGSTHLVLYRNKRRWHEYEDEDDEDSDD EENENLPVYNRGLKLLKTQPSLNTLRSKITEYGGKKYSVLLHSKRKWNEELELEFEEDKE STAEVLPFSNRGIKLLSQHPSLDVLKTKIVEYKGEPYSVLRRSKRKWSDNEWLDEDNDGR EGTETLPVYNRGLKLTSSQPGVSTLKPKTAEYNGKKYVVLLRNKRKWNDEYGEGIKEGED ERSSNLPTSNRGKKLPSLAARNHALTPKVVEYAGQDHLVLYRNKRRWSDDGTSASESEDD SQSPNLATLNRGSKLMMPTATMDTLHSKVVEYDGVNHLVLFRNKRKWNDDEEDDEDEDED VQPPALVVSNRGNKLSSSGPADGDLRTKLVEYDNTSQVVYRRSKRKWNAEHGVNDDDNDD YPEVNGVTTNRGNKLLQKKRSLNNSKPIDEEYNGSEHNLLQRKRMKFNP-KFVEDKNEDD DESDTNISTNRGNKLKRAAPPLGNHRLKIVEYNGVRRPVLYKRRRR---DNDDDDGNNDD NNLSKLVNVRELLTPISSLADICKRDSIKRTFNRTILKDLALNCILMIEKEQNSVTTYSQ NDLNNLVAVKEILSPISSLKDVIQHPSHSRTFGNQALKELALSNVLMVEKEQENVINYSK DDLSKLVNIKEILTPILSLGDVINHKTISKTFSSLILKNLATQIILMIEREQMSVVRYSQ VDLNNLVNVTETLSPIASLADILNENGKTHSFHDNVLNKLALYVILMIEKEQNSLIRYSR DDLSKLVNVKEILTPILSLGDIINHKTISRTFSSPILKNLALQIILMIEKEQMSVVRYSQ DDLSKLVNVKEILTPILSLGEVINRKTISRTFSSPILKDLALQIILMIEREQMSVVRYSQ ------------------------------------------------------------ DNLSELVNVKEILTPILSLGDVINHKTISRTFSSPILKNLALQIILMIEREQMSVVRYSQ ------------------------------------------------------------ EDLHDLVDVRKVLSPISSLADVATHPAVSRTFQSKVLRDLALDMILMVEKEQESVISYSR DDLHRLVNVRKILAPIASLSDVVEHPAASRTFKSTVLKDLALQLVLMVEREQESVISYSR EHPLKKSRIIELLSPLNHPSEIISHPAISKTYKSQTLSKLASELIDLIEIEQTNLNWLNK LDLHKLVDLRQVLAPVSSLEDVVTHPAVSKTFKSKAFGELALQAVLMVEKEQANVIWLSK EHPFKRLKLGEILSPLTHPSEVISHPAILKTYKLPIFNKMSYELIETIELEQNNLNWLNK EHPLKKSRIIELLSPLNHPSEIISHPAISKTYKLQTLSKLASELIDLIELEQTNLNWLNK IHPLKTARIVELLSPLNHPLELVTHPAISKTYKLQTLSKLAMELIDLIEIEQNNLNWLNK IHPLKKSRIVELLSPLNHPSEIITHPAISKTYKSQTLSKLAYELIELIEIEQNNLNWLNK ENPLKRIRISEILAPLTHPAELVTHPAVSKTYKSTCLATMASDLIHLIEVEQNTLNDLNK DHPLKRLKIAEILAPLNHPLEIVSHPAILKTYKSQVLNKLATELIELIEVEQENLNCLNK DHPLKKIRLSEILAPLTHPSELVTHTAISKTYKSPVFTNLANNLIHLIEVEQNNLNWLNK DDLNDIVDVRKMLIPISSLSDIYQQSPLLRIFKSKILNELALQSILLIEKEQDSVIKYSK SNPYRGIQLEEILAPLTHPADLPHHKSMARTMTSTTLRTLSTRALDVICQEQKHVVQFMK LLDVFLGDYPTPIYEKTLRLPKYDHSLTLKEEDNANDKDKQDKTDDEIAEEDSDPFFAVP LLEIFLGDFPDALYEDALKLPEYDHKLTFKEEDDENYISAS-SNSKSIKPEDEEAFFGLS FLEVFLGDHPEPIYESNLCLPPYNHNLTLPEDGSINETNTNSSNNETEESKDDDPFFALP LLELLLGEPPVPLYENNLGLKPYDHNLSLPDEEELSNGTTENNNNSNNDEDDDDPFFSLP FLEVFLGDHPEPIYESNLNLPSYNHNLTLPEDRNINEVNSNHINNGMEEFGEEDPFFALP FLEVFLGDHPEPIYESNLNLPSYNHNLTLTEDRIVSEVNLNCTNNETEETAEEDPFFALP ------------------------------------------------------------ FLEVFLGDHPEPIYESNLNLPPYNHNLTLPEDRNINEVNLNYTNNDMEEIGEEDPFFALP ------------------------------------------------------------ LLEVFLGDFPDALHEEQLGLPGYDHKLKLPEEDEAPDTAEDTGYKAEEGEEQEDPFFAIP LLEVFLGDYPYALYEDTLQLESYDHSLRLPDDG--------TRKEQPKVETDEDPFFALP LLQVLNGEDWFYLLEENLGLKDYDHGLDEDKKKKIEEKENNEDEFEDEEENKADPFFALP LLEAFLGDYPGPLREETLRLKEYDHNLRLRDDSDEDFANQKSRLVDQDTSPDGDPFFALP LLQVLNGEDWFFLLEENLGLLKYDHGLNDESNNDNKEAEEQTSQNEKESTEVNDPFFALP LLQVLNGEDWFYLLEENLGLKDYDHGLDEEKKKILEEKENNVDEFEDEEENKADPFFALP LLQVLNGEDWFYLLEENLGLKDYDHGLNDDKKSNLEQGQKKNNEYDDDDENSADPFFALP LLQVLNGEDWFYLLEENLGLKDYDHSLDEEKTKKINSKDKSIDEFEDDEENSADPFFALP LLQVLDGEDWFYLLEENMGLPEYDHGLDESREKQSEDSDKDSSSSPDNSQNVTDPFFALP LLQVLNGEDWFYLLEENLGLQEYDHGLDEDRSKNSEGSSKTNDLQAEQDEEVVDPFFALP LLQVLNGEDWYYVLEDKMGLEKYDHGLNDDGK-STENGNDDRITRSTNSSEVNDPFFALP LLEVFLGDIHGPLYEKNLKLPEYDHNLELPDEDECSNIENNSSEKKEEDSKEVDQFFALP LMSVFLGDDPSYILADNMQLPDY----------DMEEGEDAPRRTRQLATQEIDPFFALP NLALPESYQKLLPETPRVLEEVENLVQIALQRNQEFIRNLQKIRGCIVKCNRIRERITSW KFTESETLLSLIPKHNEISDDIETLAQIALQRNQEFIRNLQKIRNCIIKANRIRERILMW RLEQSNALLSLLPSSQQLNDEIESLSQIALQRNKEFIRNLQKIRKSVIKANRIRGRILSW VLENVSRLTKSFAKIHPDKDTLEPVSQVALQRNQEFVRNLIKIRGFLVKANRIRERILQW RLEQSNALLSLLPSSQQLNEEIESLSQIALQRNKEFIRNLQKIRKSVIKANRIRGRILNW RLKQSKALLSLLPSSQQLNDEIESLSQIALQRNKEFIRNLQKIRKSVIKANRIRGRILNW ------------------------------------------------------------ RLEQSNALLSLLPSSQQLNDEIESLSQIALQRNKEFIRNLQKIRKSVIKANRIRGRILNW ------------------------------------------------------------ K---LHGIQELSPPATGATDQLETLAQIALQRNQEFIRNLQKIRNCIVKTNRIRERILVW KFNGAETLLSLLPQQSETSEDIEALAQIALQRNQEFIRNLQKIRNCVIKGNRIRERILMW TLKRYETYQQNLESSDPLKEELINYLQVSIQRQHEYIKNLISLRNGLVRADRLKSDLYKW QLKPADILPSIITRKDQEVEEVETLAQIALQRNQEFIRNLQKIRKCIVKAERIKDRIANW KLARYEAHQNQVVDELVIQEDLINYLQVSVQRQQEYIKNLIQIRNGLVRAERLKQDLHKW TLKRYETYQQNLESNDPLKEELINYLQVSIQRQHEYIKNLILLRNGLVRADRLKKDLYKW TVKRFEAFHELLEPKGGIKEELINYLQVSIQRQHEYIENLTQLRNGLVRADRLKNDLHKW TLKRYETYQQSLEANDPLKEELINYLQVSIQRQHEYIKNLTSLRNGLVRADRLKKDLYKW KLAMYEEAQRKQAEEELVQQDLVNYLQVSIQRQYEYIQNLTTLRNGVVKADRYKSDLLKW ELKRYESHQVQFETDTVLKDELINYLQVSIQRQHEYIKNLSVLRNGIVRADRLKKDLHKW EFKRYEAFQTRSTEEDPAREELINYLQVSIQRQHEYIKNLTQLRNGLVRADRLKQDLLKW SINSAEELLSQIPNYPQIAEELETLTQIALQRNQEFIRNLQKIRGFLVKANRIKERIYAW Q----------IPYDGINRDAAEELTQIALQRCEEFIRCITSVRMGLLRADRFRGQVYRW SREVDEGVDG-------------------------------------------------- GKEQLLGAEE-------------------------------------------------- SREMEDGVDD-------------------------------------------------- SNEMSESGDE-------------------------------------------------- SREMEDGVDD-------------------------------------------------- SREMEDGVDD-------------------------------------------------- ------------------------------------------------------------ SREMEEGVDD-------------------------------------------------- ------------------------------------------------------------ GKEMDEEAEE-------------------------------------------------- AKEMGGRQEN-------------------------------------------------- GKEMYEKKSS-------------------------------------------------- GKEMTDEQLN-------------------------------------------------- GKEMYDKKSSMIQLISPIADNNTIFGNTCSNDSKAIYFAGRERKIQKDAGYYIFLGPSFR GKEMYEKKSS-------------------------------------------------- GQEMHDRKS-DENKKELLKDYRALYTNPNLLYENLRNFHKLRTEFPSKYREWYEHKDPNL GKEMYDKKSSPLDKLTDYSSTRSPHNQRIFKENEIPQILKLRDTDPEIYRCYYYHRDLNL GKEMHEKKN--------------------------------------------------- GKEMHDKKSS-------------------------------------------------- AKEMHDKKSTPEISAGEFWNNDCDTDSNDSVISLRDNFSRLGTGNTEPNDDFEDDKDFFD SKEMEDENLN-------------------------------------------------- CKEMGDQGNE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IVIEDERIFESIKMALHHLHLYPFASGLESVPQQFLNKDDLNTYHPLIFYLTGILSISMT ------------------------------------------------------------ IGYVKLPKYMSVSCRELFVHLQKTLQNLEISKINKSGRQHFTSADNIVYYLSALLSIAVP LGNYKLNDSLIIENRLMASHILKALQSLDTMKLFTMGKKKFKTDESLVCYLSGMLNQNCS ------------------------------------------------------------ ------------------------------------------------------------ FEYRKNSYNGSLTIYDLKELIRNFEPRITPKRYIGFDGKDYSCWPEWAFYFAGFLGETLP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TATTQLAVISPISVILKRLNELTIWGDNSFNMHKQNILLKYSVFQGLDTKFKSDSFWSLD ------------------------------------------------------------ QIITLLNDVSPRRLIHSKLVDYGLFTVDESLPESQFCLYTDIPPKIIKTMTDVTEGKEIK ETLKMLETRTPAELLQYVPIDIDAPSEEEAQRLARTMDLEETRRLALLSITEEEPKVEIE ------------------------------------------------------------ ------------------------------------------------------------ SFASKIREKCPTILLMDYLTPKYLKTVQHVSAEDAKFHLFSPFFETIDRKFDTYAFGFLK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AITDKAPYCDLVSEGTVIDDKFLQDPNCDHQERIYKNSFEDNITNTNNTCSVSSDPMYIR ------------------------MTLNKTYNNNGLSYPTTNVTNTFDFSNNNNNDKSRK EKASRLEEVDKSSQGPLILNNGGNNKDNDEKRNNDNNNKKKKKKKKKKKEKEEEEEEEEE EDEDAKFNRIMAELHEDMAKLNIKTSENRQYTNKTKQNKSTNTKSFSLSSNEPLDSSSKT ------------------------------------------------------------ ------------------------------------------------------------ LLTQLLSQHVKLMESNPTFMKDFVGGLEKCTYEEVLDDLQRDIAYMKVSEGDDQETKVSE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MSDDDSKLNQATDPS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ DKYHNNITEGSPLDSSEGNKSQSNSNEGYQKRETTKGTNPKAVNEYSKYNTSSLNQQTES TIYQLIYGELKTKNDNERNRTGGKYTLGS------------------------------- EEEEEEEEEEEKEKMMMNSKTNDGDDENEEDKKIEDTDNENKENSLSSQNIFNALYSKNL TSFEFFQPQQFTMYKLKHPLFMPISEEFLSDSSDDELIFGENYNSESDSNCSESEVEQEP ------------------------------------------------------------ ------MAAFMPMDLLARARDEIASDEPIHVSKEGKEKPESSSSNAENIN---------- TRKDPFEGIFSSLDSDFMAEFEEKASPEPEKDKSTKTTTKDSSFQSENSTILENTTVPEI ------------------------------------------------------------ ------------------------------------------------------------ --------------MAADNNLLMQLAEMFPDHRLETLARCLEDSNNDVNLACSMV----- -----------------MDQHVESLGQLFPDLPEVKLRNALTSSNNDINLACSIL----- -------------------------MDMFPTVSRSILQEYLLENNNDLELTICLL----- ---------SSSSTSSSNDELLSILVSMFPDKPIDILHNALISSSNDIELACSII----- ---------MSMDNNDDHESKLSILMDMFPAISKSKLQVHLLENNNDLDLTIGLL----- -----------MNNDDELDSKLSTLMDMFPTISKSILQVHLLENNNNLELTIGLL----- ---------MSMDNNNDYDSNLSILMDMFPTVARSVLQVHLLENNNDLELTIGLL----- -----------MDNNDDFDSKLSILMDMFPAISKSELQVHLLENNNDLELTIGLL----- ------------------------------------------------------------ ---------------MSPDEAVQFLQELFPDRTASVLAQVLRNANGDVDTACAML----- -----------------MAEEISTLQDLFPTKTIYELETVLASADGDLSIACSML----- -----------------MNCKSMTMSKQQPCHSNPT------------------------ -----------------MNQSLTTLVELFPSINEEILQRTLTSAGGDADVACSMI----- ESENSASGLYKTEDDKEEHDVVEMLTDLFPIYPRSELVARVKSTSDVENLIDVLF----- ---------NDPDINSETIKMIENLCELFPMSTIDELRDHPTNVDHSEDLVTELFEKEKE EDEYSKFVYDEMDLDPNFIYLVEHLADCFPTFSKTDLKIRLKLTNSVEELIEELFAQQQL DIGYSEFVYDELDEDPNFIDLVETLADLFPTYAKTDLKFRLKFADSVEELIEELFIETES ---------------MTSSQQLETLSDLFPSYPRSELAARLLCSNSLDSVVEELL----- DSDYAKYVYDELDEDATFQSLFDMLVEMFPMIPRNEVKMIMRLSNSFAELIDILLLNHIE ---------QDPDPQDSFEAIMNTLTDLFPTLQHDELRARLQSSQDIEYLIDTLF----- -----------------MNEGLKLLFEIFPHKDEPSLKEALESSNGDIELASMMI----- ------------------------------------------------------------ ---ISGTHISV----GEDLHNDNTTLDELYSLFPQIPRDDIQTAYYEHKGNKEEVVLELL ---LSEVN-------SQPKNQQTDHVRELMSMFPNLSKDSIKKALDTTNGDVDEAIQDLL ---LKE---------NDEKATADNELHQLYDMFPHINCDIIKDQFITNEKSVELTISDLL ---LSDPINAIDETIDSHRNEKGMPLTELIEMFPNIDANKIRLLYKDEKKNADDLISELL ---LKE---------NDDKSTVDNELHQLYDMFPQLDCSVIKDQFVINEKSVESTISDLL ---LKE---------NDEKSAADDELHQLYDMFPQLDTNLIKSQFAANGKSVESTISELL ---LRE---------NNEKSANDDELHQIYDMFPQLDCNIIKNQFITNRKSVESTISDLL ---LKE---------NDEKSADDDELHQLYDMFSQLDCEVIKDQFVTNKKSVESTISDLL ------------------------------------------------------------ ---VEREQATA----GKAEQGRQWNLASLMEMFPKISSADIEQTYDACDGDTDLAAMSLL ---FGEEDSVNSAGSKQMSETSETGWGILLDMFPNVDQKEIKRIYEENDNDVDVIIQHLL -----------------------------------------KTHIQKNSRKVQRGGARGL ---LSEQETMS----RMQDNLLSNKANTNQEKFPDLPDAC-ENEVPRKRGAVNLKKRPVH ---SEQEDQSKSFVEETNAENYSSDVRTLKEIFPEYDFEVLRKILNRNDENIALASAVIL KKNNQKEPLLQQSKRYNQKSLYLDAVYELQVMFPSIAIKSVEKILQENNGNIEDAAIALL EQQQKQQQQQQQQQQQISSSKYGEEALKLHEIFPQISLPIIAKRLQKNNGDAEMTTMSLL RDLLEEEEKLAANQQRQVEPVYDDKVYQLREMFPNIDNATIDRKLRENNNSLEDTTMALL ---CEQRP-------QTSSRKYPEEVVKLAELFPQYSTKKISQVYHQSGQDSQVAFNSLL EDVANKAEAVKENAKRKRTKKIGNQKKALHETKEEVEREKIEKEQAEKKKQIEREQAELR ---AEQE--------RNSIEEYSLDAYRLHEMFPSHSLQDLERELNANDGNIENATIAIL ---LSEENIEHV---ESDSEKQNKDLENLYDMFPNIKRSLITSMYEDNA-DGNDLIPELL ------------------------------------------------------------ SLESIRNQKLEIDQPVLSSTVKADE----NTSKWGKTHNNIETIIRYTN-------VDRE CVN-TLSLEERNSHQSENNHQKGNSLP--KDSDWSKLNDNLEIVMKYGD-------VPRH NYE-ILQ-KLKQDQKIPPDSIQQDR----TKNNWKLTNDHIQTIIKFTD-------APKD NFE-LLSMEDKNEQENAEWSIKNNEPNDKKKNSWNSMRANIDTIVQYTM-------VSKG NYE-TLQ-KLKDNQANSPDSVKRNE----KKNNWESTNDHIESIIKFTD-------APKN NYE-VLQ-KLRENQEIIPESVEQSG----RESNWKSTNNHIETIIKFTD-------APKS NYE-TLQ---RLKEETSPGKVQQSG----KKSNWKSTNDHLETIIKFTD-------SPRN NYE-TLQ-KLKDNQATFPNNVQQNG----KKNNWKSTNDHIESIIKFTD-------SPKN ------------------------------------------------------------ NFQ-GLSGEDARMQAEYERIVRQQPDVAGRPDSWQDLRRKVADIVKYTG-------VKEG SFQ-LLSQEDVEHQKYYEEQALRREDANCSDKVWGSGKESTGLIVEYSG-------VSER GGG-NRISQDKETQ----------------------------RETSING----------- SFE-KIHGSNYIKNSTTPI----------KTNAWSSATDSIQDIQNYTH-------APLK QGD-SEEISSLEDKTKKFLMKNRNNTVQ-LQSSWVVLQTEASRLEDILN-------IPSQ ELSSGTTTAASQKQRE-------------NDNEWVEESSIVIKVCRFLQTNSNDIFLDKS DEPAEAEFTTKQSQNKQN-----------TANEWFQISTMVNRVKSFLDENANKYFLEDE SLP-TTEFSSVSSQNKF------------TVSEWNKVSGLVIKITKFLGINEDTFVLDNS AGD---------------------------------TSIDVAQICGLTD----------K EQL-AREQATLKDVKQYHRDVKHIFPDHDLNQQLQLSNGDIEAIHKLLEVPEKYVPPPTA SNRWEHKAPSRPVPKKEPKKP--------TNSSWSTFSDFSAQLSKITG-------LPVT NLD-LLNRESIHDEVGCDNGKDNQTQTNGSNNKWSESSSDIKIIVDYTD-------VSDS ------------------------------------------------------------ RASKYYTNNLFSAPLAIISIIRDGYEQPIISKTNTTNRKTAFRKGAIR------GGRVQS IAQDLYMEQRLDPIRALIQLIFTYEEQVSKYHQLRKPVIKPTP-------------RVQS IAQKYFVENSFDPIGAVIKIVLDYYDKDHFTQTSTTANAKTRFTAPVR------GGRVQS RAREAFLNNQFNTVLAIIDIINNLHPNERKTEKILPFTTGKNHSYA--------GSRVQT IAQEYLAENGFDTVKAIIKIILDYYDKRDFKKDVDTFKVKRSPNTTVR------GGRVQS VAQKYFVEGGFDPVRAIIKIILDYYDKNDFPKNSITVKAKKRPTATVR------GGRVQS IAQKYFVENGFDPIRAIIKIILDYYDKSHFIENVTTVKTIRKPYAPVR------GGRVQS IAQEYFVENGFDPVRAIIKIVLDYYDKSDFKENVNAVKVKRNPNTTVR------GGRVQS ------------------------------------------------------------ QAKAAFFKNSCNAPAAVADIISSGVAR-----SESTEQQSPVPAAVAVP-----GGRVQA IAKSAYYRNSFNASRALIDLIYNYKEYIKR--DDKDISRPTTPNILANDKFSRVGGKVQS ------------------------------------------------------------ IAQNAFYKKSLNPARAIIDIIYHYTQYLLEFSESSSLSSPPREHETTNVKLTNTGGRVQS QLLSYLHKHEGKFHETLIAIINDNSVKRLS--ASSASSSSSRSSLSSFSRHVPKGGRVQG DVLHYTRKNGGDYYKTLYDVVMNCKSMVLTKQQESTSGGATKTHDKSRN-----NRRVQR EITHYARKSNGNYFDALTGIIMNCRPKIRKE-VIVATTKKKV------------GGRVQR DIAHFVRKSGCNYYDALVGILMNCRPS-----VLQTVRKQQV------------GGRVQR EVQPYLSKYNNDPLTAIADIIANHKKTRKAW-----------------------TSRV-- EIPNATIKKNGDRIQALIDIIFNCLRANNGQITLVALIKKGVQSRKRSNSHDIQGGRVQR HTSSYLHRSQGTFINALIAIITTHKAPE----PQPTNDKPPR------------GGRVQR KAKHYYYKNNHDIILSIIDIIDEYSEKRGTIDESSTIHMTSKSTNCIK------RGTVQN ------------------------------------------------------------ SHGIAHRKQNGLDLKTENSFEHLVTDNMSD-------TISTVEAPTYEDVADLKKLLSGE QNGFTHQRS------RNEKPSPKPDVGIPSKPTKFFQERTYQYDPCNEQALALDDLIQSD SMGLAHVLK------QGEKSTKEGEENTKR-------ATTYKHSLSSPQMIELNDMIEGN NRGFAHPMIRTN---RQANMYTSSDAEQHSDEDNKTEPAQFIYSLQNKKVIELQELVNGN STGLAHVLK------KGKESANVAQESLKR-------PRSYKHSLDSPQMVELNELVADN SIGLAHVLK------KSESLTKAGGKSTKR-------PRTYKHCLNSPQMIELNELIAGN SMGLAHVSK------QDAESKKVRQVSLQR-------SRSYKHTLSSPQMVELNGLIAGN SMGLAHALK------MDKESTNVAQESLKR-------PRSYKHSLNSPQMVELNELVAGN ------------------------------------------------------------ RAGLAHTVTYSSRPRPPAEAHAASDGLAMQ-------RARYVYSPGSPEAIELAELVRAN SRGFAHARD------SGEKDLKSRGYSPEIADSDVPLNSSYKYSLQNKEGIELEEILRSN ---------------NDAKPIPI--------------PSNYRYDEHSMEAKELWSLVPVN VRGLAHSKHISAAIPAETKKSKSQGTASSI-------KQTYVYHPSSDEAMELNSIIGSN PSSK-----------PTNPAPSIRYGSIPP-------EDSYTYDENSLEAKEIKAIYVGN GGAMGLASSTRNRILHGQEPQNEISTTTPT-------PSNYRYDENSMEAKELWSLIPVN GGSRLAAN-------RGRTTTEI-----------RVVSTDYKYNPNATESKELWQFYHSN GGKK-----------GGRSSVKTITKLV---------KSNYRYNPISNEAKELWELVPSN ---------------QDRKSAVV---------------TGVVLPVDTASLRELQEIILAN G--------------KTRNVSAVSVKIINKKSPNPTIEKKVLEYLNSPEAKELYLLYHSN GGAKGGSR-------RGNGSSEK--------------VFTYKFNPNSSEAQELRALYLSN NNGFAHF--------KGKEARNSLYEVLSSEKDNTSKTNTIDNDQNSNLEIQYKEIIKGN ------------------------------------------------------------ QTLSAFNMEFINKAYRYYHLNLDKLASLINYLKLNSASKLTFITEKMSAESLQHSTDDVG KKLRAINHKFLERALEYFNGEVAPTVSLAILITERKYAKYTGQYLSLDGKNANGAQFKYQ HDLKAINHEFLQKCLQFYDGDITKVLDLSSLLIKDD-KSITKTW-----------NIDGG LTLKSISPKFYRQCIIYYNGDVDKTLALALYIIKNNMANATFTT---ARDTVDINFIEVN RDLKAINHEFLQKCLQFYDGDVVKVLNISSLLIEDD-KNITKTW-----------NFDEG HALKVINHEFLQKCLQFYDGDVMKVLDLSSLLLKDD-KSITKTW-----------NLDEG HDLKAINYEFLQKCLQFYDGDVVKVLNISALLIEDD-KNITMTW-----------NFDEC HDLKAINHDFLQKCLQFYDGDVVKVLNISSLLVEDD-KNITKTW-----------NFDEG ------------------------------------------------------------ IQLASLSRELLQSALEYYAGDVTRTIETAAFIIGARPA-----------------LREPK IYLKSIKHTFFEKALEFYNGDVTKTILLGKLIMDTNCAQYTYGY-----------LAKPQ SKYSNINEVFAIKALEFFQGDVYKVVELISELSSSPISSNKQSK-----------QFNE- PSLKAINPEFLKQALIFFDGDVAQTTLVAVFIMDCDAARFTF--------------IDVG PEFKSINEQFFEKSLVFFRGDVAKVIEIAALLVQDKAGHITFRQPPAMSFSSISQAGTGK KDGKNINKKFAIKALEFFQGNVYKVIELISELSSSQISSSKQSR-------HLNEKQPVD PDMQMLDKTFLINALEFFRGNCDQVLSLAFELAQEKGPSLSPSW----STGINNGLSSKG EQLKSINKTLLINALEFFQGNVYKVIELVSELSSNQTPQHTIN------------TATQR EELKKLNYDFLVKSLAFF-GNVDKTISVAQLFIDHSDTTFLTSL-------GYVPKECPQ PSFHGISEQFLYMILNTVNGDVFKSIEICRLIIEYHCEHLTIGT------GKVERRAEEP PQMKTINEVFVNTALTFFRGNVDRTIEVIMLVLDHGAAPLTYPN---SMEPATNAQKTVV ELSKVIDNKVLYRVYCFYNGNVERTLLLVTLLIDNHYTNITVPVEEYKKISGVGLEIERK ------------------------------------------------------------ MRVPYSKTIKKKSTVNTSPALT-----------------KNMIQGKENFQIANKMVVEFF ITPLRAKTVSPSVPTFTAAVIPGTKVKQRTVTTSSLRINESQFRNPEHYKTGLKMIENIM FTLTSQDNCKQHSSKPSTPPISHKNGV-----------NKSPFQNEETREEAAALINNLF YKKQPKYDSYKKNMKPSNSKPETRGAS-------------SLLNEPKGIREGTQMISRLF FTLTSRDNCKQHLPKFSTPQISRRNEV--------GNTYKLPLHDKETPEGAVPVINNLF FTLTSQNNCKQHVVKSSIPPAFHKNRV--------SSLYESPSQNNETHEGTASIIENMF FTLTSKDHCKQHLSKASTSLISHRNEV--------SDSYESPFQN----KEAISLVNSLF FTLTSKDNCKQHSNKLSTPQIPHRNEV--------GSTYKLPLHDKETHEGAVSVINGLF ------------------------------------------------------------ RRPATTRKVSQPRRPKRPAPPELRNSL---------------FSSTKAYNRALELARAVH YGTVTTIKSVKKPVIRTTKVAHEENTL----------NFDVFVDD-ESYKKGLTIVQDTF -KRQPFDVKINKPSSPSSTLEYQSDNV--------------SFNS----DDEQQLFNKYL PKVPIVKHHQNLKTCPGTTTAKEKAAS-----SDSTVLDPASFVSDESYDNAVKICEDVF RKKSVSLIEPYKPSNLNSVSPTVYVSLSDSNSGSIIATSSRSPTPTDEISLMKEKLKSAA IKIENSKFGMPKDSSNNTFIPSSTREY---------QTDRIILDS----HDEQYLFDRYL LKTAPIKFAPKQTTDSYLILAQKFKTY-TAKRKASVSLFSSSSSSIIKPSGQIERLNTYI LEHPVIKFVPKVENDPYALIKKKFSSYADTRSSRARAKARSGVPD----ISEQNRFYQYI VGPKAADVLKKKHVPFQTVSPKPRNAV--------LCAWKPNTNTSSKSSTVHTTVSSPP EEMTYVDAIKNKKPKQQTYGDDAMDMM--------SIKFESFKSRREEITHSHKTEYNAR STNPVIDLSSQSSEKYRAMYNVLRQRITNQTSTGTKDHYREVLKESEEEDRKQRAIDAAF FTLPTTNKIIKKKIESPQILESTQSHL-----------TNSGFNSTTSFEEAKKMMKDMF ------------------------------------------------------------ NTYKLDFHGFLPQEAVRIADICLTQWWAEELSNRELNAGKLNM--KKSQYMSPVTLITGR TSPKLDFHGWFPEDAHLVTSECLKRWWKQELSCRELNNQRLNQ--IQVMNVPNITIITGR QTYRLDFHGFLPNEAVSILKLALNKWWSKEVTERELNSHNINTYGSKVQFVSPLVVVTGR ETYSLDFHGFLPSTAVELLKKALEIWWGEELSEREMNAK-RSITNNKALYVKPLTVITGR QTYRLDFHGFLPSEAVSTLKLALNKWWSKEVAERELNSHNINSYGSKVQFVSPLIVVTGR QTYRLDFHGFLPNEAVSTLNIALNKWWSKEVAERELNSHNINAYGSKVQFVSPLVVVTGR QTYRLDFHGFLPNEAVSTLKLALNKWWSKEVAERELNSHNINSYGSKVQFVSPLTVVTGR QTYRLDFHGFLPNEAVSILKLALNKWWSKEVAERELNSHNINSYGSKVQFVSPLIVVTGR ------------------------------------------------------------ SSWRIDLHGFLVDDAEALSEYVLASWWQRERELRELHCQRMSQ--SLALNMPPLTVVTGR TNYRADLHGFLPDEAVSIVRECLKKWWAEELILREQKAQRLNQ--RIVANVKPFTIITGR KTGTVDFHGFTVVEAMKLVPLILNHWWNQELIHRQSIGQ-LQKFGNSAS-LGSVLIITGR NNYTADLHGFLPHEATLITQTCLKTWWSEELALREINGHRLNQ--IKAVNVAPFKVITGR KTNTLDLHNLTVPIALEATGQALRDWWKDELDQRHVDGN-LTKFGSRVQFVNPLNLVTGR KTGTVDLHGFTVVEAMELVPLILHHWWNQELTHRQSIGQ-LEKFGNLAS-LGSVLIITGR GTGRLDLHNFKLVDAIQTTKLVLSHWWDQEKKQREEQGQ-LQKFGNLAQFVHDIEIITGR ESGHVDLHRFRLTEAMKLTKLVLQHWWEEEEKNRELDGK-IDRFGDKAS-IGPVRIITGR PSSKIDLHGLTVAQAISVTKNAVSDWWSAELAARVEHGL-IDKHGTKVSFVEPLCIITGR KGGTIDLHNLRLATAMEHTKRALRAWWDHEMELRTVDGR-MDKFGSRAACVAPFVVITGR NSSSLDLHGLSVPSALEAAREVLGAWWAYETEQRHTHGQ-LSKFGVSTVFAGPLRVITGR LTSKLDFHGFQPNEAISTLDACLKVWWEKEESERELTAT--NKKYSKVLFLSPITVVTGR ------------------------------------------------------------ GIHSAGGFSKVRIAIVKYLQNNYYIFEEFPSYFIVNGKGKVFG--MFSR----------L GLHSVGGIPKVRKRIQKFLTENNYNYIEESSLFVVNGKKRNIC--MFRSVFR-------A GIHSVGGVSKVRLQVKNFLEKNHYVFWEESSFFRVEGKKRK------------------M GMHSVGGISKVRVQVKKYLTSNNYIFWEEPSFFTIEGKKSSK---MLRTFFRS------S GIHSIGGISKVRLQVKSFLEKNHYIFWEESSYFRIEGKKKK----MFRSVCR-------I GIHSVGGISKVRIQVKKFLERNYYIFWEESSFFRIEGKKRK----MFRSVCR-------I GIHSIGGISKVRLQVKSFLEKNHYIFWEESSFFRIEGKKKKK---MFRSVCR-------I GIHSVGGISKVRLQVKSFLEKNHYIFWEESSFFRIEGKKKK----M-------------- ------------------------------------------------------------ GLHSVGGVSRVRVRIQRLLDKQHYVYDEEPSYFIVKGRRPK----MLSSFIR-------A GIHSVGGVSKVRKKVKYFLENNTFVFLEEPSFFIVEGKK------MLRSVFR-------A GIHSTGGVSTIKASVNRYLINNNYIFNQTSGSFEITGKRMNNK--MFKLAFR-------- GLHSVGGISKVRIKVRSYLESNAYVYLEEPSFFIVQGKRKA----MFKPMLR-------G GIHSQGGKAKIRIAVKKYLTRNNYVFEEYSGRFEIEGKR------MFRLAVR-------- GVHSTGGVSTVKVSVNRYLTNNNYIFEQTSGSFEVTGKRINKK--MFRLAFR-------- GLHSVGGVSLIRKYVKEYLVRERFVFDEQVGKFDVKGKRK-----MFRIAAR-------S GIHSANGVSILKRYVKEYLVNNRYVFNEEIGSFEVIGKKRR----MFRLALR-------- GLHSSGG-PKIRHSVIKMLNQNGYVYEEEVGQLYVMGRRK-----MFKFAAR-------- GIHSAGGVAVIRRGVKNFLDSAGYLYDEHTGRFEVTGKI------MFRLAVR-------- GIHSKNGVSQVKIQVRKLLDSERYAYDDDGGSYAVYGKRK-----MLRNFM--------- GIHSINGVSKVKLRVKKYLDENNYQYWEEPSYFRIEGKK------MFRQLLRT------A ------------------------------------------------------------ VPRLATRALIPSTVIARPMLVTPM--------LMRQYSV---KSKDEISQKLIEVVKNFV APSLTRV-SGLRSGFVKPTFSS----------ASRFYASSS-LSKEEITTRIADVIKSFD AP------SASRTMLARPVMANTIL-------AQRFYSAN--LSKDQVSQRVIDVIKAFD TPLTLR--RISASPVAARSASTFIGRQSFT--PMRFYSAGAALDKDEVTRRVIDVIKAFG SSRVAP--SAYRTIMGRSVMSNTIL-------AQRFYSAN--LSKDQVSQRVIDVIKAFD SPRIAS--SAYRAIMGRPVVAKTL--------AQRFYSAN--VSKDQVSQRVVDVIKAFD SSRIAP--SAYRTMMGRPVIANTIL-------AQRFYSAN--LSKDQVSQRVIDVIKAFD ---------------GRSVMTNTIL-------AQRFYSSN--LSKDQVSQRVIDVIKAFD ------------------------------------------------------------ TPRAFR---YASLQRSTPLASAFVVT------PLRFYSAAQ-LNRDEITKRIINVVKAFD VPNVLR--ASSARATFAPVTSTFVSS------PIRFYSSS--LGKEEVTTRIIDVVKAFD -------------SIRAPVARASFVK------PIRFYVAPP-ISKDEVTSRAIQALKTVA SSAALR--VVSARSIFRPAVSSSFAS------PARFYSSS--LNKDEISSRIIDVVKAFD --------AARAPVARAPLASNFVK-------PIRFYAVAP-ITKEEVTTRAFDALKTVA --------SIRAPVARASFVK-----------PIRFYVAPP-ISKEEVTTRAIQALKTVA SAR-----AVSLPVQRLPLVNN----------AMRFYAGTP-ITKDEVVSRAFEALKTVA -------------SVRSPVVARTSFIK-----PIRFYVAPP-LSRDEITTRAIQALKTVA --------ALRAPVVRAPVTKFVQ--------PIRFYAAAP-ITKEEVTSRAFEALKTVA --------SARVQMARAPVAAAIVRA------PVRFYAVAP-ITKEEVTSRAFEALKTVA --------RSSRVLARTPVVTRAWT-------PVRFYAAPP-ISKDEVTNRAFEALKTVA TPLAHR--QAAIATKRTSIVPQS---------LMRYYSASG-LTKDDVTTRIVDVIKAYD ------------------------------------------------------------ K-GES-SQ-NVTADSKFHKDLGLDSLDTVELIVSIEEEFDTEIPDDVADRLTSIRETIDY K-TAS-AT-SITANTQFSKDLGLDSLDTVELLVSIEEEFDIEFPDKVADELKSVGETVEY K-NSPSANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADDLRSVGETVNY K-SNA-AA-TITPTTLFNKDLGLDSLDTVELLVAVEEEFDIEIPDKIADELKSVAETVDY K-NSPNANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDY K-NSPNANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADDLRSVGETVDY K-NSPTANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADDLRSVGETVDY K-NSPNANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADDLRSVGETVDY ------------------------------------------------------------ R-TPT-SA-EVTEKSVFSKDLGLDSLDVVELLVSVEEEFDIDIPDKVADEIKSVSEAVDY K-TTA-SA-DVTATTQFSKDLGLDSLDTVELLVAIEEEFDVEIPDKVADEIKSVGEAIDY P-LQE-S--NITLESSFQKDLGLDSLDTVEALVALEEEFDLEIPDKISDEIKTVGEAVDY K-TTA-SA-NITNDTHFAKDLGLDSLDTVELLVAIEEEFDIEIPDKVADEIKSVKEAVNY A-LQE-S--KLSLEASFQKDLGLDSLDTVEALVALEEEFDLEIPDKISDDIKTVGEAVNY P-LQE-S--NITLDSSFQKDLGLDSLDTVEALVALEEEFDLEIPDKISDEIKTVGEAVDY T-LQE-S--KLSLESSFQKDLGLDSLDTVEALVALEEEFDLEIPDKIADDIKTVGEAVDY P-LQE-S--NITLESSFQKDLGLDSLDTVEALVALEEEFDLEIPDKVSDEIKTVGEAVDY A-LQE-S--KITLEADFQKDLGLDSLDTVEALVALEEEFDLEIPDKISDEIKTVGQAVDY A-LQE-S--KLTLEANFQKDLGLDSLDTVEALVALEEEFDLEIPDKISDEIKTVGEAVDY A-LQE-S--KLDLNASFQKDLGLDSLDTVEALVALEEEFDLEIPDKISDEIKTVGEAIDY K-SLA-AK-PISLESTYNKDLGLDSLDTVELIVAIEEEFEIEIPDKVADELKNVGETVDY ------------------------------------------------------------ LASQKN-----------------------MAR---------------------------- IASSPEAN---------------------MAR---------------------------- IASNPDAN---------------------------------------------------- ITSNADAN---------------------MAR---------------------------- IASNPDAN---------------------MAR---------------------------- IASNPDAN---------------------MAR---------------------------- IASNPDAN---------------------MAR---------------------------- IASNPDAN---------------------MAR---------------------------- ------------------------------------------------------------ VASTSDAA---------------------MAR---------------------------- ITSNPEAN---------------------MAR---------------------------- IYKEESK----------------------MAR---------------------------- IESNPEAN---------------------MAR---------------------------- IYEEEQKL---------------------MAK---------------------------- IYKEESK----------------------MAR---------------------------- IYKEETKE---------------------MAK---------------------------- IFKEESK----------------------MAR---------------------------- IYEEEQKL---------------------------------------------------- IYEEERKL---------------------MAK---------------------------- IYEEERKL---------------------MTK---------------------------- IVSNPDAN---------------------MAR---------------------------- ---------------------MSTAFSHARGR---------------------------- ----------------------------------------Q------------------- ----------------------------------------Q------------------- ------------------------------------------------------------ ----------------------------------------Q------------------- ----------------------------------------Q------------------- ----------------------------------------Q------------------- ----------------------------------------Q------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------NFIGLVVSQG-KMQKTVKVRVERKVFDKRINKELMKRKDF --------------------NFIGMVISQG-KMQKTVKVRVETKVFDKRINKELFHRKDY --------------------------------MQKTVKVRVERKVFNKKINKELFHRRDY --------------------NFVGLVVSQG-KMQKTVKVRVESKVFNKKINKELFHRKDY --------------------NFLGLVVSQG-KMQKTVKVRVETKVFNKKINKELFHRRDY --------------------NFLGLVVSQG-KMQKTVKVRVETKVFNKKINKELFHRRDY --------------------NFLGLVVSQG-KMQKTVKVRVERKVFNKKINKELFHRRDY --------------------NFLGLVVSQG-KMQKTVKVRVETKVFNKKINKELFHRRDY ------------------------------------------------------------ --------------------NFVGLVISHG-KMQKTVKVRVETKVFNKRLNKEMMHRKYY --------------------NFIGLVVSQG-KMHRTVKVRVETKVFNKSINKELFRRKDY --------------------NFVGVVISQG-KMTKTVKVRVQGRVYDKRVDKEILTRKDY --------------------NFVGLVVSQG-KMLKTVKVRVETKVFNKRINKELFHRKDY --------------------NFIGLVISQG-KMLKTVKVRVQTKAYDTKVHKEVIKRKDY --------------------NFVGVVISQG-KMTKTVKVRVQGRVYDKRVDKEILTRKDY --------------------NFVGLVVSQG-KMNKTVKVRVLGKVYDRRVDKEIVRRKDY --------------------NFIGVVLTQG-KMAKTVKVRVQGKVFDKRIGKEILTRKDF ------------------------------------------------------------ --------------------NFIGLVVSQG-KMAKTVKVRVQRKVYDTRIHKEVIKRKDY --------------------NFVGLVVSQG-KMHKTVKVRVQTKTYDKKVHKEVFKRKDY --------------------NFMGLVVSQG-KMQKTVKVRVETKVFNKIINKELFHRKDF --------------------SFVGVVTRLGPKGSKSIKVRVTRRKYMPAILKEINFHRDF LVHDEGEITREGDLVRIEATRPLSKWKSFAIAEIIRNKGQQFALFESQA--KDDVLKEEM LVHDESEVSREGDLVRIEATRPLSKRKFFSVAEIIRNKGQQFALFQEQA--KINVASEEN LVHDEGGISREGDLVRIEATRPLSKRKFFAIAEIIRNKGQQFALYESEA--QLSVAKEET LVHDEGGISREGDMVRIESTRPLSKHKFFAIAEIIKNSGQKFAEYESMA--KLNVAKEEA LVHDEGEISREGDLVRIEATRPLSKRKFFAIAEIIRNKGQQFALYESEA--QLSVAKEEA LVHDEGEISREGDLVRIEATRPLSKRKFFAIAEIIRNKGQQFALYESEA--QLSVAKEEA LVHDEGEISREGDLVRIEATRPLSKRKFFAIAEIIRNKGQQFALYESEA--QLSVAKEEA LVHDEGEISREGDLVRIEATRPLSKRKFFAIAEIIRNKGQQFALYESEA--QLSVAKEEA ------------------------------------------------------------ LVHDEGESAREGDVVRIEATRPLSRRKYFSVAEILKNQGQRQVEFQADA--KRAVRADEA LVHDEMELSREGDLVRIEATRPLSKRKFFSVAEIIKNKGQQFALFESQA--KTNVAKEET LVHDEGSICKEGDIVRIESIPKISKRKAFAIAEIKVNKGQQFAAYEEMA--KKQVKLEEE LVHDEGEVSREGDLVRIEATRPLSKRKFFSVAEIIKNKGQQFALFESQA--KTQVLKEEA LVHDEGNLCKEGDIVRIQAIPKISARKYFAIADIKINKGQQFALYESLA--KEKVAKEAT LVHDEGSICKEGDIVRIESIPKISKRKAFAIAEIKVNKGQQFAAYEEMA--KKQVKLEEE LVHDQGNICKEGDVVRIESIPKLSKRKAFAIAEIKENRGQQFAEYEDIA--KRRIQEEDE LVHDEGDICKEGDLVRIESIPKRSKRKAFAIAEIKVNKGQQFAAYEEMA--KQQVKLDEE ------------------------------------------------------------ LVHDEGNLCKEGDVVRIESIPKISARKAFAVAEIKVNKGQQFALYETLA--KEKVIEEEK LVHDEGNLCKEGDIVRIESIPKISSRKYFAVAEMKVNKGQQFAMYESLA--KKKVAEEEK LVHDEGEIAREGDLVRIEATRPLSKHKFFAIAEIIRNKGQQFALYEEQA--KTQVTREEY YTHDEMMACQEGDVVRIEQCRPISKTKHFAVAEIKSAQGQEWLAYQKAA--PGLVEEDNK QKTKEFLERREARLGHT--DSQLLKDVKFLQSYFGKVNSEGGNEAQANELKQELEKIKQR EKTKAFLERRERKQGV---ESTLLNDVRVLQKAYTD---------GTEDS-AAVKEIKSR QKAKEFLDKRSARESKSNEKTTLLQDIKIIQDALSK---------GSTP--KELSQIKER MKSKEFLDKRVQRENTYKTDINLLKDIKTIQKALAQ---------GESKSNEDLLQVKKR QKAKEFLDKRSVRENKLNEKTTLLRDIRTIQDALSS---------GSTP--KELLEIKQR QRAKEFLDKRSERERKLNEKTTLLHDIRIIQEALSK---------GSTP--KELSEIKQR QKAKEFLDKRSARENKLNEETTLLRDIKIIQDALSK---------GSTP--KELSEIKHR QKAKEFLDKRLVRENKLNGKTTLLRDIRIVQDALSK---------GSTP--KELLEIKQR ------------------------------------------------------------ ARAQAFLERREQRTTA---GTTLVADVAALQEAYTQ---------GTLDS-PEVAAIRER ARTEEFLKRRQEREEN---DSILLKDIHKIQNALSK---------GETS--QEIAEIKER KEAKKFIEHREKFSKIIT-QLDDLKKMDKLTHEITS-----NIEEDHTKLIEEINQIKEK EKTNEFLSRRKAAESN---DSVLLSDVRTIQLALSR---------GQNP--EELSEIKAR EKIEQFLERRKEYENTIV-QVEDLKTLDKLSNTFQS-----DPSADREFLLSEINAIKEK KEAKNFIEHRDKFSKIIT-QLDDLKRMDRLTHEITS-----NLEDDHTKLIEEINQIKEK AEARKFLELRKQFLNLIT-QLEDLKRLDELNFLLQNELDLENDDKKHESLINEVKSIREK QHAKQFIENRNEFSKIIT-KLEDLKKMDKLAYGITS-----NEEQDKSDLIKEMNQIKEK ------------------------------------------------------------ QKLEIFIKEKQQFESVVT-QIEDLRRLDQIVSTYQT-----QPNADRSQLLSEIDRIKQK EKLQNFLLKNEQSQAIIS-QVEDLRKLDQIHQQFQS-----NPEADKDLLVEEINKIKAK MKTQEFLQRRNAAAKSK--DSLLLEDIRIIQTAISN---------GQSP--QELKEIKDR KRTMQFNQDKEQGEEV--SALSVLEQLRQVAEYEWK-------GPRDQAHEDQVKQIKQH YGVQEFTPNTVKQLIKLDIQGVEEDLIEQKSKIDAMQGKLNDLLQEP---SKCIEYLKQR YGIDKFSPESLKQILQLDILKIETQVKQQQQKIDAITEKLAEYTKNE---SLANEFLLSK YGIQEFSQETVRELLQLDISEIELNLQKQRHVIDSIQSQTSELLLDD---LKCNQFLKDH YGIQDFTQDSIRQLLKLDITELEKNIETQQSNLETLQTKLSEYLAND---EEATSFLESH YGIQDFSQETVRQLLQLDISGLEVNLEKQRSLIDRIQTRLSELLSND---LKCDQFLKDH YGIQDFSRETVRQLLQLNISELEVNLEKQRDVIDSIQTRTSELLLDD---TKCNQFLKEH YGIQDFSQDTVRQLLQLDISILEVDVEKQRSMIDRIQSRLSELLSDD---LRGNQFLKDH YGIQDFSQETVRQLLQLNISELEVHLGKQRIMIDRIQTRLSELLSND---LKCDQFLKDH ------------------------------------------------------------ YGVSEFTPDTLQKLLELDVTAMEQEVMRQRTRLEDVLSRLEAYMQDQ---AAADAYLRSK YGIQDFSPAALKELLKLDIVQLENEVSRQQSAIDEISSQLKELLRDE---EKATELLKSK YNIKSWP--TTESTVDLGLNEPIFSDEKEK-RLYFIQYILNELMNNAKYEEIRKSIVESK YGIENFSPETLRQLLQLDIVALEQSVTAQKSKIDTVQARVRELMENE---EQGHTLLSKH YNIKSWP--STEPVLKLEVNEAAKDLTILQNRVDNIKIILEKLMSEE-YASHRQQILSDL YNIKSWP--TTESTVDLALNEPAFSDEKEK-RLYFIQYILNELMNNVKYDEIRKSIVENK YGIKSWP--TTEPVVDLELNKPIWETETQR-RTYFIKHILDELMNKEMYKEFKEKVLQSY YNIKSWP--TTEPTVDLELNKPIFSDEKEK-RLYYIKHILTEALGNEKYESWKKSILDKE ------------------------------------------------------------ WGIQSWP--SEEPILSLDINEKEKSIREV-----NLDLIISKIMSDE-YTDDRNKILAAS YNIKSWP--STEPILSLELNQDEADMTEIEKRAKNIKSILEKVMGPE-HTEFRERVLAEK YGIQEFTPETIRKLVSLDITKMENEVNLQRERIESVQAKIEDLLSDD---VKATEFLKSK YGIDSWPPN--KPIANLSLEVLRNEFSKTHSLVQATHMLQNEP-------AKAEEMLQEL GV-ESPELLQKNIMKNLVRKHVLKEL---------------------------------- GL-ENPQLLKKNIKKNILRKHILEELNV-------------------------------- GV-DDPLSLKKNIKKNLLRKHVMLDLQQSSQ----------------------------- GV-SNPSELQRNIKKNLLRKHLLQDLQLST------------------------------ GV-EDPLTLKKNIKKNLLRKHVMMDMQQPSQ----------------------------- GV-EDPLCLKRNIKKNLMRKYVMMDLQQPMQ----------------------------- GV-EDPLNLKKNIRKNLLKKHVMMDLQQPSQ----------------------------- GV-EDPLTLKKNIKKNLLRKHVMMDLQQPRQ----------------------------- ------------------------------------------------------------ NV-EAPEELKKHTRKNLLRKHITADLLN-------------------------------- GV-ENPASLKKNIRKNLLKKYIMQEALQ-------------------------------- LK-KSMEEVSKSIQKNVVRRYLLDTRNECPVPLPQ------------------------- GV-EDPGALKNNIKKNLLRKYVLQEL---------------------------------- SK-TPVEELKPFTQKNILRKFILDPRNECPVTL--------------------------- LK-KSIEKVSKSIQKNVVRRYMLDTRNECPVPLP-------------------------- FKDKPIEEVSKAIQKNVLRKYVLDEKNEIPVQFPAN------------------------ LK-HATDNTSRAIQKNVLRKYILDVRNECPVPLP-------------------------- ------------------------------------------------------------ TS-TPVGELKKHTIKNIVRKYVLNSKNELPFEV--------------------------- AK-APIANLKPFTQKNILRKFILDPRNECPVPY--------------------------- GI-EEPALLKKNIKKNILKKYVLQELR--------------------------------- GFSGKGFSQKRNILAKALRR---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MLRIPSRIGSRQVLACAGRNLKCGSVMRHISRRNISKEPEKV ---------------------MLRIGSRCVRSVPKSSLRVSSTKIGKLFVRSVSDKPEEV ----------------MIRSTVIGSSSRCVARISRRVGTIKCITTPVTTKRFISGKPNEV -------------------MLRRSATRLSTQWKPALSKRVLFNVANVVAARQISSKPEQS -----------------MIRYTVAGHSRRCVVGASKRVGAIKCITVAATKRFISNKPNEV --------------MIRHTVPGFSRRSVARLSKSVGTLRCITATAASTGKRFISNDPKEV -----------------MIRYTVAGSSRRSVARISKRVGAIKCVTVTTSKRFISNKPNEV ---------------MIRYTVAGSSRRSALGVSRRVGTIKYITTITTTPKRFISSKPNEV ------------------------------------------------------------ ----------------------MLRHSLRSASKLQSKNVRLLRAAPLLLKRSLSNDPKEV -------------------MLRTVLRTGKHTKAPIGVLAPAFTIRVTTSVRTITNKPDEM ------------MLSRVARCSRTLNQVTRNGQSGLFSAVLRTSIRQNSTDSPASNNANEI ---------------------MLRIIHRLPRQVGKATLPLRLPRPLKHCVRCISNKPNEV ----------------MLKLTSRVGPKRLSSGLKSSSFKVNATIISKKFQSSLNSKPNEV ------------MLSRVARYSRTLNQLTRTSQGGLLSAVLRTSIRQNSTDSPPSNSANEI ------------MLSKSITRSLKQQVTKKSLSKAIAPSIARSLATSTPPSPSDGLKPSHV ----------------MLSRVARNSSLLKQLPKLRQTTVLPVVLKNSIRFHATSSENKEI ------------------------MLRRIVNTGTKRLFRVPPRSSALCFSRRLSDQTKEV -------MLSRVVRQRSRSAISSFKLRAHAAFAETRIGVGISVQATRLQSTKLSANPEEI -------------------------MSIIQARCIGNLTRRSIVNVMSRRFQSLGPNPQEV ---------------MLMSKAPKLGNLLSKNSIKIVSGSKLRCNLKYINVRYISDTPDKV ------------------------------------------------------------ YTNLADVNDPK------------------------------------------------- FTKLSDENDPQ------------------------------------------------- FTKLTDDNDPK------------------------------------------------- FTKLTNENDPN------------------------------------------------- FTKLTNDNDPK------------------------------------------------- FTKLANDNDPN------------------------------------------------- FTKLTNDNDPK------------------------------------------------- FTKLTNDNDPK------------------------------------------------- ------------------------------------------------------------ FTKLTDENDPK------------------------------------------------- FTKLSDENDPK------------------------------------------------- YTKLSDTKDPQ------------------------------------------------- YTELSDENDPQ------------------------------------------------- YTKLSDSEDPK------------------------------------------------- YTKLSDTKDPQ------------------------------------------------- YTKLSHTDDPA------------------------------------------------- FTKLTDSKDPQ------------------------------------------------- YTKINDTKDPA------------------------------------------------- YTKISDSADPK------------------------------------------------- YTKISDTKDPK------------------------------------------------- FTKLSDENDPQ------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------RDQFFK- -----------------------------------------------------RDAFFK- -----------------------------------------------------RDAFFK- -----------------------------------------------------REKFFQ- -----------------------------------------------------RDAFFK- -----------------------------------------------------RDAFFR- -----------------------------------------------------RDAFFK- -----------------------------------------------------RDAFFK- ------------------------------------------------------------ -----------------------------------------------------RDAFFK- -----------------------------------------------------RDAFFQ- -----------------------------------------------------RNQFFQ- -----------------------------------------------------RDAFFK- -----------------------------------------------------RHQFFQ- -----------------------------------------------------RNQFFQ- -----------------------------------------------------RSRFFQ- -----------------------------------------------------RNQFFQ- -----------------------------------------------------RNQFFQ- -----------------------------------------------------RNQFFQ- -----------------------------------------------------RDKFFQ- -----------------------------------------------------RDAFFK- ------------------------------------------------------------ -YTWGTWLQNDKLEKDKRTTK-FSLNGLNSVLDDIYRQATKNT-KDNFKSETEIVPQPLT -YSWGTWLKNDKQEKEKRITK-FSLEGLNSVIDDLYKQSIENA----KRLSKSSIPPPAY -YTWGSWLKNDKQQKEKRFTK-FSIEGLNRILNDIYVQSNEMA-----KVAADKILPPTF -YTWGTWLKNDKLEKEKRTTK-FSIEGLNDIITDLYSQPTTTT--------QADSIPPPI -YTWGSWLKNDKQEKEKRFTK-FSIEGLNRILNDIYIQSNEMA-----KAPDGKILPPVF -YTWGSWLKNDKQHKEKRFTK-FSIEGLNRILNDIYIQSNEMA-----KVVDGKILPPTF -YSWGSWLKNDKQHKEKRFTK-FSIEGLNRILNDIYIQSNEMA-----KVPDSKILPPVF -YTWGSWLKNDKQQKEKRFTK-FSIEGLNRILNDVYIQSNEMA-----KAPDGKILPPVF ------------------------------------------------------------ -YGWGSWLKNDKQEKEKRVTR-FSIEGLNKVLSDLHEQSAQAD----KTAKTDAVPPPSY -YSWGSWLTNDKQEKEKRLTR-FSIEGLSDVLNDLYTQSRELA----KSTEKDKIPPPSY -YTWGSWLTNDKSKKKQRETT-FSIEGLTLFIDRINQLESKLA----------------- -YTWGSWLSNDSQEKEKRLTK-FSIIGLTDVI---SDLLVQSRAQAKETQDNKSIPAPSY -YTWGSWMKNDQSEKSKRETK-FSIEGITKLLQDLNVELKNQRNIDKSGEPFVKAPSQLK -YTWGSWLTNDKSKKKQRETT-FSIEGLTLFIDRINQLESKLG----------------- -YSWGSWLKDDALKKKQRETI-FSIEGLTAYLNSVDSLRVPETAKLLQPKEEQGTFVLQN -YTWGSWLKNDKLNKKKRETV-FSIEGLTLFLDTIKGFETTLS----------------- -YTWGSWMKNDKLERARRQTR-FSIEGLSKFAKDFKPQDAALG----------------- -YTWGSWLENDKLKKSHRETR-FSIEGVSNLVQELNLTRKDPANVDSSGEPLLQIKPVQQ -YSWGSWLKDNEKQRAKRTTR-FSIEGATKLIANLIKEKSDGTVKSPISKNGSSILSHNI -YSWGSWMKNDAIEKEKRVTK-FSIEGLNDVLNDIYEQTKVEA----KVTKEGAIKPPSF ------------------------------------------------------------ NKNRTVSMPNNIAITKLGTLNPNEKSVTIKTIASVHEGKHHRIYKVQTNDEKSFVLRIPY LPNLTVSLPHNVKIENIGTVNPNEK-IRIVSMASIHEGKHHRIYKIDTNAEKSFVLRIPY NKNLTVSLVNNVIPKNIGKVNPNEK-VQVTTMSSIHEGKHHRIYKVDTNLNKAFVLRIPY NNKNNTVSLPQNLTPELLGSSTKTTPVQITRLSSIHEGKYHRVYKIDTNLNTSFILRIPY NKNLTVSLVNNVVPKNIGKINPNEK-VQVTTLSSIHEGKHHRIYKVDTNLNKAFILRIPY NRNLTVSLVNNVIPKNIGKINPNEN-VQVTTLSSIHEGKHHRIYKVDTNLNKAFILRIPY NKNLTVSLVNNVIPKNIGKVNPNED-VQVTTLSSIHEGKHHRIYKVDTNLNKAFILRIPY NKNLTVSLVNNVIPKNIGKINPNEK-VQVTTLSSIHEGKHHRIYKVDTNLNKAFILRIPY ------------------------------------------------------------ NPNLTVSLPHNVTSKHLGTPKRGES-VRVVSMASFHEGKHHRIYKIDTNAGKSFVLRIPY NPNLTVSLPHNTTVEALGTVNPSER-IKITSMASFHEGKHHRIYKVDTNAGKSFVLRIPY --QPKSLEGAFVLANNKELLGSTKDKVIVRSIASIHEGKHHRVYKITLNTGKELVLRIPY NPNLTVSLPHNLSVANMGTLNPDEA-LKVTAMASIHEGKHHRIYKVDTNAGKAFVLRIPY DGSYVLTQNLTSNLIGKEDS------LLVKSIASIHEGKHNRIYKVTLSTGKELVLRIPY --QPKSLEGAFVLTNNKELLGSTKEKVIVRSIASIHEGKHHRVYKITLNTGKDLVLRIPY NLTFDVLGAKSDV-------------LLIKSISSIHEGKHHRIYKLTLSTGKDLVLRIPY --QPKHLHGSFVLGQNKDLLGEAEDKIILRSIASIHEGKHHRIYKLTLNTGRDLVLRIPY -KPEHLTNGTVALKNNWTKEILGETGHDVKSIASIHEGKHHRIYKVTLANDRQLVLRIPY LKDGSFVLTNNLS-------------NKLIGEAQDKDAKLLVKSIASIHEGKDLVLRIPY LSKTIGNDTN----------------VTIKSISSIHEGKHHRVYKISLSSDKQLVLRLPY NKNLTVSLPHNLTVKNIGVINPNEK-VQITSMASIHEGKHHRIYKIDTNLGKSFVLRVPY ------------------------------------------------------------ QLDDDKATSHRIRSEVATLDFLDLQLKM-KVPKVICYAADD---GNPLGVPFILQEYIDG ALDDENTLAYRLKSEVATMDFADLKLGL-KVPKVYSFGVNA---LNPVRQPFILEEYIEG PLENENTLAYRMRSEVATMDFADLKLGI-KVPKIFCYGVNS---LNPVRQPFVLQEFIEG PLTDQTTQKFLIESEVATMDYVSLKLKI-NVPKIFSYASDA---KNPLGQPFILQQFIDG PLENENTLSYRIRSEVATMDFADLKLGI-KVPKIFCYGVNS---LNPVRQPFVLQEFIEG PLENENTLSYRIRSEVATMDFAGLKLGI-KVPKIFCYGVNS---LNPVRQPFVLQEFIEG PLENENTLSYRIRSEVATMDFADLKLGI-KVPKILCYGVNS---LNPVRQPFVLQEFIEG PLENENALSYRIRSEVATMDFADLKLGI-KVPKIFCYGVNS---LNPIRQPFVLQQFIEG ------------------------------------------------------------ GIDEENTLAYRVKSEVATMDFADLKLGM-NVPKVFCFGVNA---LNPIRQPFILEEYVPG ALDDENTIAFRLNSEVATMDFADLKLGL-KVPKIYCYGANA---LNPIRQPFILQEFIAG KLDSDVAIASKLKSEVATTDFLKLKLGL-NVPRVLAYGVDS---NNEIKSPFILQEFISG ATTSEAAISYRLKSEVATMDFADLKLGL-KVPKVFCFGANA---LNPIRQPFVLEEYIEG KLESEYSISQKIKSEVATMDFLNLKLGA-NVPKVVAYGANK---VNSLQSPFILMEHIEG KLDSDAAIASKLKSEVATIDFLKLKLGL-NVPRVLAYGVDS---NNELKSPFILQEFISG KLESDTAIASKIKSEVATSDFLKLKLGL-DVPKIIAYGPDR---NNAIRSPFILQEFIEG KLDSDAAIAAKIKSEVATLDFLNLKLGL-KVPRVLSYGSDV---YNEVGSPYILEEFIPG RLESDYAIENKINSEVATLDFLALKLKL-NVPRVLAYGPTR---TNILQTPFILMEYIEG KLESDYSISQKIKSEVATLDFLSLKLGL-NVPKVVAYGDNR---SNALQTPFILMEYIEG RLESDVAISQKIKSEVATMDFLDLKLKL-NVPKVLAYGPDR---SNDLEHPFILMEYIEG ALENEDTIAQRLKSEVASMDFADLKLGI-KVPKTYCFGING---LNPIRQPFILQEYIDG ------------------------------------------------------------ SLLMKDWNPLM--------DDKALASLNKVVKSMADFHAKLNSISFNAAGSIYF---KND TLLMRSWTPLEEDGKSHK-DKLN-----AVINPISKFQAKLAEVKFNAFGSLYF---AKD DLLMRDWDPLMEDNSPNQ-EKFE-----NVIKQVSDFQSKLISLKLNAFGSIYF---STD PLLMRQWNPLA---DDKEKPQLQ-----NAINIVSDFQQKLNKATFKNSGSLYFSARKLD ELLMKDWDPLIEDGSSNQ-KKYD-----NVIKQVSDFQSKLVSLKLNAFGSIYF---NND DLLMRDWDPLMEDGSPNQ-KKFD-----NVIKQVSDFQSKLISLKLNGFGSIYF---NND DLLMKDWNPLMEDGSSNQ-EKFD-----NVIEKISDFQSKLISLKLNAFGSIYF---NND DLLMKDWDPLM--EDGSSNQEKF----DNVIKQVSDFQSKLISLKLNAFGSIYF---NND ------------------------------------------------------------ RLLMKDWMPLASADGSHK-EKLN-----SVIQPISEFQAKLAETEFTAFGSLYF---AKD QLLMRNWNPLADAKDGEAHKDKL----NSVIEPLSKFQAELSKIEFSEFGSLYF---AQD ELLMKKWHPLL-PDSEETNKRLH-----EVIDPIAQFQNKILSVTFNKFGSLYF---HDD RLLMRDWTPLE-----DDAPDKKLTKLNKVIEPLSQFQSKLLSIEFNQFGSLYF---AKD DLLMKQWDPLV-ADETEGSQEKL----KSVIEPIAAFQEKLLSITFNKFGSLYF---NDD ELLMKKWHPLL-PDSEETNKNLH-----EVIDPIAQFQDKILSVTFKKFGSLYF---HDD ELLMKKWNPLEPDSDKTD-EDLK-----SVIAPIAEFQDKILEPVFTKFGSLYF---YND DLLMRKWHPLS-PDSEETNKALH-----EVIDPIAEFQDKLLSVTFNKFGSLYF---HDD DLLMKQWNPLVPDSETSE-EELK-----KVIDPIMEFQDKLLSVTFNRFGSLYF---FDD DLLMKKWNPLA------ADSEETDASLKSVIQPISDFQDKILSVNFNKFGSLYF---HDD DLLMKQWEPMS----KDE-ETVK-----SVITPIADFHSKVISVEFNKFGSLYF---DKD KLLMRDWSPLE--------NDTSPVALQDVINKLSEFQSKLISMKFNGFGSIYF---AKD ------------------------------------------------------------ SNLN--------SETVIDNISNDLAS-NLKDRWVLGPSV-ERRLWKKKSDLAIE---ERL YKTS-----------EESAYEGETNE-ELKDRWRIGPSV-ERCLWRKKSTLNFD---DRK LKNT-------DDKEFANVYDGETNP-DLENRWKIGPSV-ERCLWRQKSHLDFQK--QIK PPTT-----------------AEEVE-TIDSRWYVGPSV-EKSLWRNKLQYWKLN--DLL LKDG-----NEKEFVKEDIYDGETNP-DLQNRWKIGPSV-ERCLWRHKSHLDFHK--QMK FKDA-----DDKEFVQDKVYDGETNP-DLQNRWKIGPSV-ERCLWRHKSHLNFQK--QMK FKDE-----HDEAFVKENVYDGETNP-DLQNRWKIGPSV-ERCLWRHKSHLDFQK--QLK FKDG-----HDKEFVRENIYDGETNP-DLQNRWKIGPSV-ERCLWRHKSHLDFQK--QME ------------------------------------------------------------ YRES-----------NEPAYKSDTDG-DLADRWRIGPSV-ERCFWRKKSALPFE---QRK YDKS-----------EKLAYDGETKL-DLQNRWRIGPTV-ERCFWRKKSAMDFE---DQQ VEGS---------LQNDVPYEGETDS-ALSNRWRIGPSV-ERQFTRNKNKLQQS---IID CPES-----------ETPAYDGEENE-SLQNRWRIGPSV-ERCLWRQKSALSPD---DLK VSVT---------DQSSLPYNGEENP-LLTKRWRIGPSV-EKSFSKNKNQLSEK---EIK VEGS---------LQNDVPYEGETDS-TLSNRWRIGPSV-ERQFTRNKSKLQQS---IID VTTE--------LQQNGEPYEGENDE-KLLKRWRVGPSV-EKAFTKGKNKLSQD---VID VEGS---------LQNDLPYDGETNE-DLKNRWRIGPSV-ERQFSKNKEKLPQN---LID VSAA---------NQKVVPYDEEDNL--LKDRWRIGPST-ESVFSKNKKQLASQ---KIS VSVL---------DQADVPYDGEENP-LLVNRWRIGPSI-ERQFAKNKNHLSEK---IVK VASE---------HRLDAAYEGEENE-SLSGRWRIGPSV-EKPFSKRKNKLSAK---TVA AEEL---------ENVPELYDNETNE-ELKGRWKLGYSV-ERCLWKKKSFLPTD---KLK ------------------------------------------------------------ KYLGPW-------KEDKETSISAQILRDTAILELKNAEARLAKSEQNGSKDKN------T QYLGPW-----DISSP------LDIVKCTGLLEAENARARLGLVQAHASPEVV------A PFLGPW-----SIKSP------MDIIKNTGLLEAENAKTRLALKETGSSPEVV------Q KLLGPW-----KQENV------TSIIQDTAKVQLETLKKEEK-----------------N PFLGPW-----PKKSP------MDIIKNTGLLEAENAKTRIAMKEAGSSAELM------Y PFLGPW-----SIESP------MDIIKSAGLLEAENARMRLALKAAGSSPELV------N PFLGPW-----PIKSP------MDVIKNTGLLEAENAKTRLAMKEAGSSPELV------E PLLGPW-----SKKSP------MDIIKNTGLLEAENAKTRLAKKEAGSSPELV------C ------------------------------------------------------------ QYLGPW-----TISQP------LDIVKSLGSLEAENARARLAIKQADASPEAEI-----D KFLGPW-----SISNP------MDIVRDTGLIEAENAKYRLALKQADASSEAV------E QYNGPW-----DASNP------TAVLESVADIELENAKSKLSLINADAGANEN------D KFVGPW-----AKSEP------MEVVKSLGLLEAENARARLALQQADASPAPI------S QYSRSI-----DADKP------LETITSIAGIELENLRNRLALAQADSGNKVE------N QYNGPW-----DASNT------TALLESVADIELENAKSKLALINADAGANEN------D QYNGPW-----DASNP------EQVMTSVAEIEIENARNKLAIVDADAGDVT-------S ELNGPW-----DASNP------IALMESVADIELENAKNKLALINADAGANEN------D QFNGPW-------DSV------EKMLKDLAEVQVESLRFRLGLAQADSSNQVE------D EFNGPW-----KADAP------LSLITSVASIELENAKNRLGLAQADSASKVE------D QHNGPW-----KADEP------LQLITSVTEIELENLKNRLALSQADAGSDLE------N TFLGPW-----SINKP------TDIIRATGLLEAENAKVRLGLKEADSSSEAV------E ------------------------------------------------------------ ETLIKKQIETFQNVEKISGDLISSEMKAIPNIK-DLLKPTIFHPDLDPMNVLIEN-KTE- EDILKDQIKTFDNLAKVAPDLINTKTTSIPKME-NLLKPRLHHPDLDPMNVILKE-DDD- PQTLKEQVTTFENLAKIAPNLFNVKTKSIPNMQ-ELLSPRLFHPDLDPMNIIITK-ESQ- AATLSDNILTFQNLTHLAPSLFESSITKIPNLK-ELLKPRLFHPDLDPMNVIIDAKTKE- PRTLKEQITTYENLAKIAPDLFNVKTKAIPNMQ-ELLSPRLFHPDLDPMNIIVNK-EAQ- SQTLKEQVTTFENLAKIAPDLFNVKTKAIPNMQ-ELLSPRLFHPDLDPMNIIVNK-ESQ- SQTLEDQITTFENLAKIAPDLFNLKTKAIPNMQ-DLLSPRLFHPDLDPMNIIVNK-EAQ- SRTLEEQVTTYENLAKIAPDLFNVKTKAIPNMQ-ELLSPRLFHPDLDPMNIIVNKEAQE- ------------------------------------------------------------ EQVLRDQITAFENLAKLAPVMYNLKTKSIPNMD-AIVKPRLCHPDLDPMNVILHE-ENG- ESLLREQITTFERLAKIAPLLFNTETKSIPNIK-TLLKPRLYHPDLDPMNVILNEAEGN- RALITKQIKTFENLKKISPQLINDKSKSIMNVE-VLFKPRLYIPDLDPLNVIQHSDTEN- ESVLTEQIRTFENVAKLSSSLFDTKSKVIPNIE-ELLKPRLYHPDLDPMNVLLPENSTD- VELIQKMIATFENLKTMSTKLFNPNSQSLMNAE-ELFKPRLYCPDLDPLNVILNSNKNN- KVLITKQIKTFENLKKISPQLINDKSKSIMNVQ-ELFKPRLYIPDLDPLNVIQHTESEN- KDLLQHQITTFEHLKQITPKLLNSKSPSIKNVE-ELFKPRLYVPDLDPLNVIQST-EGK- KDLINKQIKTFEHLKKITPLLINTKSKSIMNVE-ELFKPRLYIPDLDPLNVIQQG----- VDQLKKQIQTFENFKIISDKLLNPSSPAIKNVE-ELFKPRLFVPDLDPLNVIVEQ-KSS- VEVLKKQIETFEHLQAIGSKLFNSKSKSIMNVE-ELFRPKLFVPDLDPLNVIESN-DKS- QENLKKQITTFEHLKVMGPKLLNPKSKSIMNAE-ELFKPRLYVPDLDPMNAIINVNRDN- SGVLKSQVATFENLVKLAPSLINSETKSIPNIS-DLLLPRLKHPDLDPMNVLVTE----- ------------------------------------------------------------ -----TPFMLDLEGAVVKPFILQSS--PQFVAYDG------PKIYNMKSDI-PE-FEKL- -----VPYLLDFEGSSIKPYILQNT--PQFVAYDG------PKIYDLEKDI-EG-YKDM- -----EAYLLDFEGACTKPFILQNS--PQFVAYEG------PKIYELKEDI-KD-FDKL- ------PYLLDFEATTIKPTILQHS--PQFIRYDG------PKIYDLQKDT-PE-YKEL- -----EAYLLDFEGACTKPFILQNS--PQFIAYDG------PKIYDLKEDI-TD-FDKL- -----EAYLLDFEGTCTKPFILQNS--PQFIAYEG------PKIYDLKEDI-SD-FDKL- -----EAYLLDFEGACTKPFILQNS--PQFIAYEG------PKIYDLKEDI-TD-FDKL- ------AYLLDFEGACAKPFILQNS--PQFIAYDG------PKIYDLKEDI-TD-YDKL- ------------------------------------------------------------ -----KPYLLDFEGTTVKPFILHNN--PQFVAYDG------PKIYDLERDV-EN-YSKL- -----TPYLLDFEGASIKPFILQSS--PQFVAYDG------PKIYDLEKDI-DG-YQDL- -------YFIDFEGSTIKPFILTS--YPKFVAYQG------AKIYNLEEDV-PG-YKEM- -----SPYLLDFENTCIKPFILQNA--PQFAAYDG------PKIYNLEEDV-EG-YKDL- -----EPYFVDFEYTSIKPFILSS--YPSFVGYQG------AKIYNLEEDI-PG-YSEM- -------YFIDFEGSTIKPFILTS--YPKFVAYQG------AKIYNLEEDV-PG-YKEM- ------NYFIDFEGSTIKPFILSS--YPKFVEYQG------AKIYDLKVDI-PG-FDEM- ---KDVNYFIDFEGSTIKPFILTG--YPKFVAYEG------AKIYNLEEDI-PG-YNEL- -----KPFFIDFEHTVIKPFILAS--YPAFVAYQG------TKLYNLEEEI-PG-FKDM- -------YFIDFEYSTIKPFILTS--YPNFVAYHG------AKVYNLEEDI-PG-FTEM- -----EPYFLDFEYSTIKPFILSN--YPPFVAYHG------AKVYDLENDI-PG-YADM- ---NNEVYLLDFEGSSIKPLILQNA--PQFVAYDG------PKVYNIEKEV-PD-YEKL- ------------------------------------------------------------ S-EEERKHYEFMYKRTRNQFLWEKAVNERLPNLIMTVAPP---VKVLRRPYTAVLEQKTD E-ESEKAKLEFMYKRTRNQFLWEFALNENLPELISSVAPP---IKVLRNPYVAAIERKSD S-EPEKVQYQFMYKRTRNQHQWEKKLNENNSQLITAVAPP---VKLLRSPYIAAVERKTE S-DAEKQQYEFIYKRTRNEYMWENAMNERTPDLITTMAPP---IKLLRSPYVASLEMKDE S-EAEKVQYQFMYKRTRNQHQWEKKLNDNNPKLITAVAPP---VKLLRSPYIAAVERKTE S-EAEKKQYQFMYKRTRNQHQWEKKLNENNPQLITAVAPP---VKLLRSPYVAAVERKTE S-EAEKAQYQFMYKRTRNQHQWEKKLNDNNPQLITAVAPP---VKLLRSPYVAAVERKTE S-EAEKAQYQFMYKRTRNQHQWEKKLNDNNPQLITAVAPP---VKLLRSPYIAAVERKTE ------------------------------------------------------------ N-AQEKDQYEFMYKRTRNQYLWESQLNQNAKHLISSIAPL---VKLLRSPYVYAVQRKYD S-EPEKAQYQFMYKRTRNQYLWEFALNKNAKELISSVAPP---VKLLRSPYVAAVERKTD E-ELEKQQYEFMYYKTRNERMWEFELNKYRHDLIAIASPH---IKVLKSPYLQALDVKNG S-EAEKVQYSFMYKRTRNQHLWESALNKNTKKLISAVAPP---VKLLRSPYVACVERKND D-EVEKQQYQFMYYKTRNERLWELELNSRKHDLIAVASPH---VKVLKSPYVQALDFKND E-ELEKQQYDFMYYKTRNERMWELELNKYRHDLIAVASPH---IKVLKSPYLQALDIKNG D-PVEKQQYEFMYYKTRNERLWEVELNKHRHDLIAVASPH---IKVLKSPYLQALDLKHS D-ELEKEQYAFMYYKTRNERMWEFELNKHRHDLIAVASPH---IKVIKSPYLQALDLKTD D-DVEKQQYEFMYYKTRNERLWEFALNNKRHDLIAVASPH---IKLLKAPYLQVVNCKTD D-EVEKQQYEFMYYKTRNERLWELELNSRRHDLIAVASPH---VKVLKSPYLQALELKTD D-EVEKQQYEFMFYKTRNERIWENDLNSRRHDLIAVASPH---IKVLRSPYTQVLEYRND S-DSEKAQYEFMYKRTRNQFLWEMAFNKTNPEFISIVAPP---VKLLRSPYIAAIERKTD ------------------------------------------------------------ NDYILVDDSFFQ-LR-EAWAFF----FKNGLVTKEEF-PL-TFTDEQVKQHADDLNSLHE EEYLLIEEALLQ-LA-EVWPIF----ANNKLVNAAEY-PL-KYSEEEVKKHADALNAYHE EEYLLVDESLLQ-LK-EVWDIF----AQNDLVKQKKF-PL-NYTKEDIERHVKDLQNLHE LEYLLVDEAMIQ-LS-KVWSTF----YENGLVKEKEF-PL-KFTEDQIKKHNDELTAFHE EEYLLIDESLLQ-LK-EVWDIF----AQNELVNQKKF-PL-NYSKEDIERHVEDLQKLHE DEYLLIDESLLQ-LK-EVWDIF----AQNDLVKQKKF-PL-TYTKEDIERHVKDLQKLHE EEYLLIDESLLQ-LK-EVWDIF----AQNDLVKQKKF-PL-NYSKEDIERHVKDLQKLHE EEYLLIDESLLQ-LK-EVWDIF----AQNDLVNQKKF-PL-TYSKEDIERHVEDLQKLHE ------------------------------------------------------------ QEYLLIDEALVQ-LK-EVWELF----AKNELTNSEQF-PV-EFTEEWLRQHAEKLNAYHE AEYLLIDECLIQ-LK-EVWDIF----AKNSLVNSDKY-PL-DYTEEQLKKHSKDLNTFHE KDYLYVEGSIVQ-LQ-AMWEAY--VANELVNSKDTKF-PI-EYTAEYLDQHQQELSDYQL MEYLLIDESLIQ-LR-EVWEVF----AKNKIVKDETF-PL-EFTEDQLAKHANDLNAFHE KDYLYIEGSIVQ-LQ-AMWEAY--VANELCNATETEF-PI-AFTAEYLDEHQKDIEDYQM KDYLYVEGSIVQ-LQ-AMWEAY--VANELVNSKDTKF-PI-EYTAEYLDQHQQELSDYQL KDYLYVEGAIVQ-LQ-SMWEAYVANELVKQDKDDKEF-PI-KYDEKYLDQYQLDLSDHQM NDHLYVEGSIVQ-LQ-ALWEAY--VANELVNSKDSKF-PI-EYTAEYLDQHQQDLSDHQL KDFMFIENAIIQ-LQ-AMWEAY--VANQICNSTTPEF-PI-EYTAEYLDEHQSDLENYQL KDYLYVEGAIVQ-LQ-AMWDAY--VANELCGSSSSEF-PV-QYTEEFLDRHQTDLEEYQI QDYLYVEACIVQ-LQ-AMWEAY--VANELCNSSDAKF-PI-EYSKEYLDKHTQALNQYQA EEYILVDEAMIQ-LK-EIWDIF----TKNGLVKNSPY-PI-EYTTEQLEQHGKDLLKFHE ------------------------------------------------------------ KLVSTPF----------AATQGW-VPQ-DMFDNLVRAGV--IIKDSTG----------NF KLISQPF----------AATQGW-MPQ-DMFDNLVQGGI--LVKNEKG-----------D KLISTPF----------AATQGW-VPQ-DMFDQFLKSGI--IVKQENG-----D-----Y KLIRVPF----------AATKGW-VPQ-DMFDNLLKNGI--IVKDKDG--------NYSI KLISTPF----------AATQGW-IPQ-DMFDQLLNSGS--IVKQENG-----D-----Y KLISTPF----------AATQGW-VPQ-DMFDHLLKSGS--IVKQENG-----E-----Y KLISTPF----------AATQGW-IPQ-DMFDQLLKAGS--IVKQENG-----D-----Y KLISTPF----------AATQGW-IPQ-DMFDQLLKSGS--IVKQENG----------DY ------------------------------------------------------------ KLIAEPF----------SATQGW-MPQ-DLFDNLVKSGV--LVKDANG-----D------ KLVSRPF----------AATQGW-IPQ-DMFDNLVESGV--LVKNKDG------------ ETVSSPF----------SATGGW-IPQ-DMFDTLKAQGILVETKDGNY---KVETEKVLE KLIKSPF----------AATQGW-IPQ-DMFENLVKAGI--LVKGKDG------------ EIVSTPF----------AATSGW-VPQ-DMFDSLKEQGIIVETENGDF---------KVE ETVSSPF----------SATGGW-IPQ-DMFDTLKAQGILVETKDGDY---KVETEKVLE ETVSSPF----------SATGGW-IPQ-DMFRTLKEQGILVEVGEGNYEIKTDKILENPP ETVSSPF----------SATGGW-IPQ-DMFNTLKDQGIIVETEDGNY---KIETEKVLE EVASTPF----------AATGGW-VPQ-DMFDVLKEQNI--LVEDENG-----NYKIEAD ETVSSPF----------AATGGW-IPQ-DMFETLKEQGIIVETENGNY------KVEAEK DIVSTPF----------AATDGW-VPQ-DMFDQLLEQGI---LVEENG-----EYKVATE KLISQPF----------AATQGW-IPQ-DMFENLVAGGV--LVKNKSG----------DY ------------------------------------------------------------ TVNDINPSA--------------------------------------------------- YVISRTEDA--------------------------------------------------- IVKKPEPIK--------------------------------------------------- ASEPKSKST--------------------------------------------------- TVKQPEATK--------------------------------------------------- AVKQPETSS--------------------------------------------------- TVKQPEHTK--------------------------------------------------- TVKQPEPTK--------------------------------------------------- ------------------------------------------------------------ ----HSLKQ--------------------------------------------------- DYTVNTQHV--------------------------------------------------- NPPAQPEEK--------------------------------------------------- ---NYSIKE--------------------------------------------------- TENVLKESE--------------------------------------------------- NPPSPSEEK--------------------------------------------------- SETGEEPKA--------------------------------------------------- NPPKPEEKN--------------------------------------------------- AALKNPPKD--------------------------------------------------- ALEEEPEEK--------------------------------------------------- KVLKPEEGE--------------------------------------------------- EVSSEAQSE-----------------------VQSEVQSSTENKD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -------------------------------MNVEENDDLYGILAEKNIKFV-------- ------------------------------------------------------------ ------------------------------MAGSIDQSLITSTRQLKGKKNG-------- ----------------------------------------MESRRVSKKRLG-------- ------------------------------MARSLSQSLTATTQKLKGKKNG-------- ------------------------------MAGSVGQSLRATTQRLKGKKNG-------- ------------------------------MAGSIGQSLTATAQQLKGKKNG-------- ------------------------------MAGSLGQSLTATAQQLKGKKNG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSVTTTTNIIKASPK----------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MLATTTNIITASPK----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------MHDDPLDDEEEEEPPRNIGRVVFG-------- -------------------QLG----LFKKFETWYGTAVY----------------FN-S ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MHGM----LQSSLNTTITDPILN------------------- --------------------------MFDTTDNPITSPKRK------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ME-D ------------------------------------------------------------ ---------------------------PREFDTWYHSSAYY---------------FS-Q EN--KKLGFYDETQMKPGQQGNGY------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LHEKTSKNVAKRRKGKGKG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------PNIPDKNSNQPTSIPATSASASASASASASA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GG--QVPLVEN------------------------------------------------- ------------------------------------------------------------ KD--ELKKLTWKRAMALMEAKALDKDKDNHTCDMSRLFIER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GRGSKIIKGKT--VKKKKMTN---------- -----------------------MVPKPDKHNSSTEDEEI-------YGI---------- --------------------------GKGKNKSSANLKKD--HKEMLYGI---------- -----------------------------KDDSNTSDENL-------YGI---------- --------------------------GKGKNKPSAKIKKT--QKEMLYGI---------- -----------------------------GKGKNKSSKKA--RKEMLYGI---------- --------------------------GKGKNESSAKIKKG--QKEMLYGI---------- --------------------------GKGKNKPSAKIKKI--RKEMLYGI---------- ------------------------------------------------------------ -------------------------------MKSSSSPSD---EGDLYGI---------- ------------------------------------------------------------ -------------------------------RKTKTDTKD--QDNSYYGQ---------- -------------------------------MGKRSYAEK---DEELYGI---------- -------------------------MLATAKSNPKSSKYE--EDNEFYGV---------- -------------------------------RKTKANTKE--QDNSYYGQ---------- -----------------------------SGATSTSKTNS--KSTPFYGQ---------- --------------------------------KARNKDTE---DNSYYGQ---------- -------------------------------------MSE-------YGV---------- -------------------------MSDGRTQAKKSVPKDEGYDNGFYGV---------- -----------------------------GSKVPKSRLRA--SKNDFYGI---------- -------------------------------------MVEIVEEENLYGI---------- -----------------------------YSSPSVGTPGG-------TSS---------- ------------------------------------------------------------ ---------------------LDK------------------------------------ ---------------------LNE------------------------------------ ---------------------LNE------------------------------------ ---------------------LNE------------------------------------ ---------------------LNE------------------------------------ ---------------------LNE------------------------------------ ---------------------LNE------------------------------------ ------------------------------------------------------------ ---------------------LDK------------------------------------ ------------------------------------------------------------ ---------------------LNK------------------------------------ ---------------------LKK------------------------------------ ---------------------LNE------------------------------------ ---------------------LNK------------------------------------ ---------------------SNF------------------------------------ ---------------------LNK------------------------------------ ---------------------LAE------------------------------------ ---------------------LDK------------------------------------ ---------------------VDF------------------------------------ ---------------------LNE------------------------------------ -ALTSSTISS-----------SGS------------------------------------ --------------KAL-----SSLN-DHALSNI-----QLKSNPKTSDNQF-------- --------------PNIRH---VQFGLNKRFATWYGSNVYFGRNKRTLGFKESNNEHTAK --------------RNIKQ---IQFGVSKRFPTWYGSAVYFDPETKRLGCSESKGQVHCG --------------RNIKD---VQFGMDKRFLTWYGSNVYFDNETEQLGIKDNGNSNTDS --------------RNIRQ---IQFGLNKKFSTWYGSAVYFDPETKRLGCSETKGQLSSV --------------KNIKQ---IQFGVSKRFPTWYGSAVYFDPETKRLGCSESKSQLCSN --------------RNIKQ---IQFGLSKRFPTWYGSAVYFDPETKRLGCSESKCQLSSA --------------RNIRQ---IQFGLSKRFPTWYGSAVYFDPETKRLGCSESKGQPSSV ------------------------------------------------------------ --------------PNIKQ---VQFGLGKRFKTWYGSAVYFARDKRTLGYKAKNVGMCDR ------------------------------------------------------------ --------------RNINK---VTFG-KYEFPTWYGNAAYFYPHDLSHSSLGYEYANKVA --------------ANVRE---VQFGLDKRFSTWYGSAAYFTHGTTLLGIKDVENTSRRP --------------PNIGK---VVLG-NYEFDTWYGNAAYFSSQPHSILGYEFLNKIVTA --------------RNINK---VTFG-KYEFPTWYGNAAYFYPHDLSHSTLGYEYANKVA --------------INIGK---ITLG-KYKFQPWFSNTAYFYPHEGSHDQLGYEYANQVS --------------RNINK---VTFG-NYEFSAWYGNAAYFHPHDLSHSSLGYVYANKVA --------------RNIER---VSFG-DYDFNTWYGNGAYFSPGSSDLGVDCCISGRRKS --------------PNIKT---VLFG-NYRFNTWYGNAAYFNAYDTAHMALGYDFSNRIA --------------RNIDK---VTLG-NYEFHTWYGNTAYFSRANNSHPELGINTLVPRK --------------RNINY---VQFGCNKKFQTWYGSTVYFDPDNKLIPDRPNVKNSPRK -----------------SA--------NASVAPN-----DQPPAQVDFQ----------- --------------------------------------------WL--D--TLYVCEYCF QSPTEKKFEDQY--------------------------------WI--D--TLYVCEYCF SNNKY---------------------------------------WL--D--TLFVCEYCF KDKQSTDVHSLTGKTRF---------------------------WL--D--TLFVCEYCF SNSQY---------------------------------------WL--D--TLFVCEYCF FNDQY---------------------------------------WL--E--TLFVCEYCF SSERY---------------------------------------WL--D--TLFVCEYCF SSGQY---------------------------------------WL--D--TLFVCEYCF ------------------------------------------------------------ SMDESTEGGF----------------------------------WL--D--ELFVCEYCF ------------------------------------------------------------ SEGSIARKIHKKDIFDENLHEF----------------------WL--D--HLFVCEYCF SSQPDMEKDY----------------------------------WL--D--VLYVCEFCF TGQKGKKKVIDQITETESIKPKNDSL------------------WL--D--KLYVCQYCF SEGSMARKIHKKDVFDENLHEF----------------------WL--N--HLFVCEYCF LEPNSRRRLKITDR------------------------------EC--SIKNLYVCEYCF MEGSGARKIHKKDMFDETLHEF----------------------WL--D--HLYVCEYCF APVRAPHF------------------------------------WL--D--CLYVCDFCF SDPSTVTNTENSNIDNNHNDDDY---------------------WL--N--ELYVCEYCF KHLGGDPTSDF---------------------------------WL--K--TLHVCEYCF PLQKNGQY------------------------------------WL--D--TIYICEYCF --------------------------------------------VK-----QLFVCDSCF KYTDVKDDFVNHV--HQCS-FKE-KAP--GRIKY-------------------------- KYTDDEAELIAHE--CFCR-YKN-KPP--GRIKY-------------------------- KYTDDQTVFVAHA--AACP-FQK-RAP--GKIKY-------------------------- KYSENEENFRLHA--ERCRHKH--SAP--GRIKY-------------------------- KYTDDQTRFVGHV--ASCP-FQY-RVP--GKIKY-------------------------- KYTDNRARFVVHA--AVCP-FQY-RAP--GKIKY-------------------------- KYTDDRTRFEAHV--AFCP-FQY-RSP--GKIKY-------------------------- KYTDDRTRFVAHV--AVCPFQY--RAP--GKIKY-------------------------- ------------------------------------------------------------ KYYDRPDELVGHV--KSCR-YKL-RLP--GRIKY-------------------------- ------------------------------------------------------------ KYTSNETILNQHV--TACT-YNR-KRPSKGKLLY-------------------------- KYTDDATALQKHV--PCCKYNA--KPP--GRIQY-------------------------- KYTDKQQFMGQHQ--AVCP-LNT-RFPSIGKLLY-------------------------- KYTSNETTLNQHV--TACT-YNR-KRPNKGKLLY-------------------------- KYSQSGTAVVAHQ--HICPNNV--PKPKVGSLAY-------------------------- KYSSQEHELNLHV--AKCQ-QNR-TRPNLGKLMY-------------------------- KYSTDRALMAQHR--AICP-LNKAYPP-LGTLVY-------------------------- KYTSNSHEMQQHR--VVCS-YNV-ARPKVGKLLY-------------------------- KYCAEKSSMSSHR--SVCTKNT--PFPQTGRLVY-------------------------- KYCDSGEMLCDHD--LVCNYKY--KAP--GRIKY-------------------------- KYSKVSKDMAQHR--STCKYVF--KHP--GETVY-------------------------- -----------KS--PQYTIRRVKGSKHQLFCQCLCLFTKLYLDNKSVFFKLDHYEFYIV -----------RS--PEYTIRRVKGSKHEVFCQCLCLFTKLFLDNKSVYFKVKHFEFYIV -----------KS--PEYTIRRVKGCKYQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIV -----------KS--PQYTIRRVRGYKHTLFCQCLCLFTKLFLDNKSMYFKVNHYDFYIL -----------KS--PEYTIRRVKGSKYQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIV -----------KS--PEYTIRRVKGSKYQLFCQCLCLFTKLFLDNKSMYFKVDHYEFYIV -----------KS--PEYTIRRVKGSKHQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIV -----------KS--PEYTIRRVKGSKYQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIV ------------------------------------------------------------ -----------MS--PEYTIRKVKGKKHELFCQCMCLFTKLFLDNKSVYFRMTSYEFYIL ------------------------------------------------------------ -----------HDQANGYIIREVRGFQDPLFCQNLCLFGKLFLDDKSVYYNIDHFDFYIV -----------MS--PEHTIRKVHGTMHLLFCQCMCLFTKLFLDNKSMYFKLDNYDFYII -----------RDDESPYFITHVRGFKHQLFCQNLSLFGKLFLDDKSVYYNVDAFDYYII -----------YDQANGYIIREVRGFQDPLFCQNLCLFGKLFLDDKSVYYNIDHFDFYIV -----------YDYEKGIVIREVRGYQDPLFCQNLCLFGKLFLDDKSVYYNVDHFNFYIY -----------RDQKNGYIIREIRGFQNPLFCQNLCLFGKLFLDDKSIYYNIDHFNFYII -----------ADSKSRRVIKRIRGFRHELFCQNLALFGKLFLDDKSVYYNVDAFDFYVV -----------RDDHTPYLIREVRGFTDPLFCQNLCLFGKLFLDDKSVYYNIDHFNFYIV -----------RDPISKYVIKQVRGYRHQLFCQNLCLFAKLFLDDKSVYYNVDAYEFFII -----------LG--PKYCIRRVKGSKHQLFCQCLCLFTKLFLDNKSMYFKIDQYDFYIL -----------KS--KDYAIRRVDGAVHKLYCQNLCLFAKLFLDHKSVFFGADAFEFYVV YETG-K------------------------TIPMAFFSKDLVSYN-QNNLACILTLPPYQ YENN-S------------------------TVPMAFFSKDLYSYH-QNNLACILVFPPYQ YETG-S------------------------TKPMGFFSKDLVSYQ-QNNLACILTLPPYQ YETT-T----------------DLSMK---NKPLGFFSKDLVSYD-QNNLACILIFPPYQ YETG-S------------------------TKPMGFFSKDLVSYQ-QNNLACILIFPPYQ YENG-S------------------------AKPMGFFSKDLVSYQ-QNNLACVLTFPPYQ YETG-S------------------------EKPMGFFSKDLVSYQ-QNNLACILIFPPYQ YETG-S------------------------TKPMGFFSKDLVSYQ-QNNLACILTFPPYQ ------------------------------------------------------------ YNTE----------------------G---REPLGFFSKDLYSYN-RNNLACILVFPPYQ ------------------------------------------------------------ FGKD-D-------------------SS---YIPMGFFSKEVLSYDNDNNLACICVFPPFQ YQTS-T------------------------NKPMGFFSKDLLSYQ-RNNLACILTLPPYQ YGLD-Q-----------HQDLSYPEEN---FVPMGFFSKEVLSWDDDNNLACICIFPPFQ FGKD-D-------------------SS---YIPMGFFSKEVLSYDNDNNLACICIFPPFQ YAKP-D-----------------AKEN---YKPMGFFSKEMIAYDNSNNLACICVFPPYQ YGKD-D-----------------YSTN---YIPMGFFSKEVLSYENDINLACICVFPPFQ YAPE-T------------NHDAGERAR---LKPMGFFSKEVNAWDEDNNLACICVFPPFQ YGYD-N----------DVNADPYTEQH---FKPMGFFSKEMLAYDNDNNLACICVFPPFQ YGHP-D-------------TGSEIDRN---MVPMGYFSHELGAWDNDNNLACICVFPPFQ YEIN-S------------------------TIPMAFFSKDIISYN-KNNLACILTLPPYQ LGKDSS-------------------RH---FKPMGFFSKEKLSWD-ENNLACILVFPPYQ RMGLGSLLIEFSYHL---SRLE---GI--VSGPELPLSPFGLIGYLRYWSLVICWQL--- RRRLGTLLIEFSYTL---SRCQ---GL--ISGPEVPLSPFGLIGYLKFWSFSIVWQL--- RRGIGSLLIEFSYKL---SQLE---GV--ISGPEVPLSPFGLIGYLKYWSQILYWHL--- RRRLGSLLIEFSYKL---SKLD---DI--ISGPELPLSPFGLIGYLKYWSQIISWEL--- RRGLGLLLIEFSYKL---SQLE---GV--ISGPEVPLSPFGLIGYLKYWSQILCWHL--- RRGLGLLLIEFSYKL---SQLE---GV--ISGPEVPLSPFGLIGYLKYWSQILCWHL--- RRGLGLLLIEFSYKL---SQSE---GV--ISGPEVPLSPFGLIGYLKYWSQILCWHL--- RRGLGLLLIEFSYKL---SQLE---GV--ISGPEVPLSPFGLIGYLKYWSQILCWHL--- ------------------------------------------------------------ RRNLGTLLIDFSYRL---SRNE---GI--VSGPEFPLSPFGLIGYLKYWSFAIVWHL--- ------------------------------------------------------------ RRHLGSLLIEFSYQLAAVTPGQ---LK--SSGPEFPLSPYGKVTYLRFWSKRLATKI--- RRGIGSILIDFSYKL---SIRE---GQ--VSGPEKPLSPFGLVSYLKYWSSVICWQL--- RRHLGSLLIEFLYALARVTPGQ---FR---SGPEFPLSPYGKMSYLHYWSRKLAYIL--- RRHLGSLLIEFLYKLAAVTPGQ---LK--CSGPEFPLSPYGKVTYLRYWSKRLATKI--- RRGIGQLLIELLYMLSSPTSNS---DR--RTGPEVPLSPYGKAAYLKYWSACVVQSL--- RRHLGSLLIDFSYQLARVTPGQ---YY--GSGPEYPLSPYGKMTYLRYWSKRIVRVI--- RLRLGSLLVEFSYALARVTPGQ---AR---SGPEFPLSPFGQATYLRFWAKRLAFVI--- RRHLGSLLIEFLYAL---AHVT--PGQ-YHSGPEFPLSPYGKVSYLRFWSKKLASVI--- NRRLGTLLIDLSYEV---PRAH---GQSEPTGPEYPLSPFGRATYLRYWAKRLAHIL--- RRRLGTILMEFSYKL---SRSE---NV--ISGPETPLSPFGLISYIKFWARIIAYEL--- RRGLGKLLIEFSYVL---SKYE---GR--KGSPERPLSKFGTLSYMSYWCTTIARFI--- --------------------------------CEGDLSNFE------------RLSI--Q --------------------------------TEGNLKDVA------------QVTL--K --------------------------------IEGDLAHFD------------KVSL--E --------------------------------TEGELCDFD------------SVTL--E --------------------------------IEGDLAHYD------------KVTL--E --------------------------------IEGDLAHCD------------KVSL--E --------------------------------IEGDLAHFD------------KVTL--E --------------------------------IEGDLAHFD------------KVTL--E ------------------------------------------------------------ --------------------------------TEGELSNLH------------KVSL--N ------------------------------------------------------------ -----------------------------------HELQGS-------------FTL--S -------------------------------LEGNLSGCGR-------------ISL--T --------------------------------LQTFKINEE-------------FNL--S -----------------------------------YQQSGS-------------FTL--S ----------------------LEYGSVSNGGTELFSKNTD----------LLKVTL--D -----------------------------------DESQES-------------FTL--N --------------------------------WNDFSTAES-------------VSL--R --------------------------------TSHFKPGLS-------------FSL--N --------------------------------SCSLQRKTS-------------FTL--Q -----------------------------------FDGELS---------ALGKISV--T ----------------------------------LIECTED------------VITI--E DISLATGIRISDIIPTLKHLNCI------------------------------------- DLSEATGFRINDIIQALKYLDCL------------------------------------- ELSIVTGMRVSDIILTLKHLNCI------------------------------------- DISKVTGLRINDIIMTLKHLECI------------------------------------- DLSIVTGMRVNDVILTLKHLNCI------------------------------------- DLSIVTGMRVSDIILTLKHLNCI------------------------------------- DLSIVTGMRVSDIILTLKHLNCI------------------------------------- DLSVVTGMRVSDIILTLKHLNCI------------------------------------- ------------------------------------------------------------ VISEVTGIRVSDVIITLKHLQCL------------------------------------- ------------------------------------------------------------ HLSKETGFRKEDILLTLEYMQIL-----------------VTDD---------------- TISESTGIRIGDVVLTLKSLKCL------------------------------------- SLADITGFRKEDILLTLEYMQIL-------------------QD---------------- QISKETGFRKEDILLTLEYMQIL-------------------VK---------------- QLGAANHLRKEDVLFTMEHMGIL------------------------------------- DLSRLTGFRKEDILLSLEFMGVL-----------------VSDS---------------- DLADKTGFRKDDCLLALEYMGVL------------------------------------- DISDFTGFRKEDILLTLEYMKLL-----------------KKDL---------------- DLSDLTGFRKEDILLTLEFMQVL----------GKKVVSQNGEE---------------- DISLVTGFRLSDIIMTLNYLECL------------------------------------- TISEHTYIQPEDVMRALKEMHAV------------------------------------- --------------IDENHINL---KVLKQWLK--------------------------- ---------------SDSEIRL---NIIRSWARR-------------------------- --------------GENNQIYL---QALNTWFKS-------------------------- --------------GEENRIYL---DKLRRWLKT-------------------------- --------------GENNQIYL---QSLNSWLKL-------------------------- --------------GENNQIYL---QSLSTWLKS-------------------------- --------------GENNQIYL---QSLNTWLKT-------------------------- --------------GENNQIYL---QSLNTWLKL-------------------------- ------------------------------------------------------------ --------------TENNEILL---PVIRRWAKE-------------------------- ------------------------------------------------------------ --------------LGNVTLSL---ERLENWCSQ-------------------------- --------------NDKDEISL---SALRLW----------------------------- --------------TGNGNVSLS-LGNFNQWCTE-------------------------- --------------DGNGNVALS-LEYLEHWCSQ-------------------------- ------I-------TENDKVYVS-LKALNKWKDK-------------------------- ------T-------TGDVSLCI---DNLKHWKKE-------------------------- --------------FEAEEVILE-RRALRGWCDA-------------------------- --------------RGNVKLLL---GNLQEWCTA-------------------------- --------------EGCKPVLS--LENLRQWCVR-------------------------- --------------SSSGEILT--SIIKDKVQKM-------------------------- ------------------VLYS--DEKAKKVQLG-------------------------- ----------THTKPGQNPFMINEEYLLIDD----------------------------- ----------NKVSHGFM---IKDEYLLLDD----------------------------- ----------HGAKGNWFK--LQDEYLLIDD----------------------------- ----------HERTFM-----IEDQYLLLDD----------------------------- ----------HGTKRNWFK--LKDEYLLIDD----------------------------- ----------HGTKGNWFK--LQDEYLLIDD----------------------------- ----------HGAKGNWFK--LKDEYLLIDD----------------------------- ----------HGTKGNWFK--LKDEYLLIDD----------------------------- ------------------------------------------------------------ ----------LKVDRGFM---IQEQYLLLND----------------------------- ------------------------------------------------------------ ----------NKVVPGVDINILNSECLIL------------------------------- ----------MKENSSYQQSLINDEYLVLDN----------------------------- ----------NNVDPLQEKTMLNPNYLLI------------------------------- ----------NRVIPGVDINILNSECLIL------------------------------- ----------KKKTHDSINYLLQPKYLSKLV----------------------------- ----------NHYDPYKELDALDTSCLII------------------------------- ----------NNVDPTVLATSLDPAGILF------------------------------- ----------NNVDPNQEKSMMNTEYLLL------------------------------- ----------NRVETSQDMRMLNPDYLVL------------------------------- ----------SGKITGYI---IQDDDLLLDD----------------------------- ----------GRVLKKSVRRWVNSGNV--KLSPVIDESMVFLE----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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-----------------------------------------PPCKLICATSGVSHQLSNV -----------------------------------------TTATIINAISGESITTNVD -----------------------------------------NKTTIINVTTGDPQLTSLK -----------------------------------------TTATIINAISGECITTNVD -----------------------------------------TTATIINAISGESITTNVD ------------------------------------------------------------ -----------------------------------------TTVTIINAISGECITTNVD ------------------------------------------------------------ -----------------------------------------GNLQLVNAISGRSIGTHVQ -----------------------------------------YNTTVINAITGKTLPTNID -----------------------------------------SYLSINNAHNGIIIKIKPV -----------------------------------------DNATIYNAITGTQVTANIQ -----------------------------------------SYLTLYNAHNGDSVKIKPI -----------------------------------------SYLSINNAHNGVIIKIKPV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SYLIIYNAHTGTSSRIKPI -----------------------------------------MHLTIHNAHNGLTTSIKPI -----------------------------------------MSSNIINAITGELITIDIT -----------------------------------------SEIRVSCASSGVSVSAARD VFLDLKEFKSYLSNKWGVPRAQILLLYPFGIKLKDASDLESPEIYVYDRRLFSLEQRRHP YFPSFLDLKQFASDTFQIPLDDILLLLPYGMILKKLQQEGLEEIYVFDRGIFNEEIEFSP FFVSLDEFKQFITRKWNIPADQLLILLPYGNKLKPNRSFTLNEFYVYDRRLFSSRVSPYE YFIKFQHLLTFIANKWQIPTNQILIILPYGSKLTSSYHVDQGPLYVFDRRLFQHHRKRKD FFVSLDKFKQFIARKWKIPPDQLLILLPYGNKLKPNRSFTLNDFYVYDRRLFSSHISQYQ FFVSLEKFKQFISRKWKIPPDQLLILLPYGNKLKPNRTFTLSEFYIYDRRLFSSHISPYQ ------------------------------------------------------------ FFVSLDKFKQFIARKWKIPPDQLLILLPYGNKLKPNRSFTLNEFYIYDRRLFSSHISLYQ ------------------------------------------------------------ YFMTMEDLKRFVIQQWHIPGPEIFILQPYGGKFKRGRVRETSVLYVFDRRLFDALAQATR YFMAIDDFKHFIVQQWFIPLDQIFILLPYGAKLKKRENNGRCEFYVFDRRLFSLLESANR RFHTLSEFKKYIQQSSIDSVDNLFLLTTFGIKLNYNLINEIGEVFVYDKRLFTSLIDQYT WFLSVEDFRRFVSQQLMIPVEQCFILLPYGSKLKNRRGSTQPEFYVFDRRLFSLLESVTK RFHSLNGLKSFIHESIISDIENIFLLTSFGMKVKFNIINELNDIYVFDKRLFSAYVNQNE RFHTLSEFKKYIQQSLIDSVDNIFLLTTFGIKLNYNLINEISEVFVYDKRLFTSLIDQYT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RYHSLGDFKRFLQTQHVDSIDNLFLLTLFGIKLNFGLINELNEVYVFDKRLFGEVLSQYT RYHSYQSFKEYIVESILDDANNVFLLTQFGMRVDFNIINELNDIYFFDKRLFVDYATQ-- LFISLNEFKKFLINRWQIDFNNLLLLLPFGNKINDGKKNDQSTIYVFDRRLFSKGINHPT QFSSLPHLKAWIELEFSVSVSEQLLLTVAAEQVKMAHLGTQNELFVFDRSVVGSNEHKYS QLQDDLIRPIPSPLEDIADGISHRTAVSMLTTNLGWLSALEIDVNYYSSISDKCKEDTQS KPRFQLFKPLPSPISD-----SLQLDKNVILRNLGWLKALQSDVEFFQDVIKETYQDVQR GSDTIMIKPMSSPLEDTVPRLDYHTVTSLLTTNLGWLSALEIDVHYFRSLIPDIITQITQ TELIMLVKPIHSPLEETETELTYNKVTSLITTNLGWLSALEIDVHYFANIIKDTMNEVVH GSDTIMIKPMPSPLEDDLSRLNYHSVTSLLTTNLGWLSALEIDVHYFKSLIPDIIAHIKR GSDTIMIKPMSSPLEDALSHLNYHTVTSLLTTNLGWLSALEIDVHYFKSLIPDTISQIMH ------------------------------------------------------------ GSDNIMIKPMPSPLEDDLPRLSYHTVTSLLTTNLGWLSALEIDVHYFKSLIPDIIAQIMR ------------------------------------------------------------ HDSTTLVRPLVSPLEDAEAEVGERAAASLLTTNLGWLSALEIDVRYFHACIEGWVQQLAN SSQVTLIRPINSPLLDSAGSLTGRRIISLLTTNLGWLSALEIDVHYFHKVINDTLTETQQ QSTFRVSEPTHSPLLKSNVGFLKQNLSSNLKINQGWARIITQDGELMDQYCRELIQQINV QNRVTLIKPVPSPLLEVNHDLTQRKATSLLTTNMGWLSALEIDAHYFHSLIQKTINEIQN GGYKEMIKPTPSSLVK-LEKTNIKQMTSSLKVNDGWSKALFQDCLGVVGQMKAYVKQINT QLTFRVNEPTHSPLLKNNVGFLKHNLSSNLKINQGWARIIAQDGELMDQYCRELIQQINV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AESFEVVKPTPSTALA-LTETQIRIISSSLKSNQGWARAIVQDCHHTEELAKELVRNINA -----TMRDIPPPKHPYSRGLNIRQMSSSLRSNAGWSMSVKVDAALADEQVRAYKRQISV NNLNQLVKPVNSPYEENEKFLNYHTITSLITTNLGWLSALEIDMHYFQIQISDTLDYIKN APKLKTLTPGTDPSQ--------------------WALTVLTHCSRLVEETKRVTAEIAT LARCLGTCEQYLGLYCYDVERLYNSNVVFLDQLHENSLQSRWKECYKNTLTKLAG-LNGY LLECGTVMLEYLKNYCYEVEVLYNGNVDFLNKLHEDGASNQWHSFYDNILGNIKV-SNQL IFNSLTVCSQYLKLYCFDVETLYNSNVQFLNQLIDNGMTSKWEKCFKDTLSKLTGLEGDS LLDSLCVCEQYLKLYFFDVMKLYDSNVQFLQQLQGKGLVSHWQQCYESILSKLNC-EETS IFDGLTVCSQYLKLYCFDVESLYNSNVQFLNQLVDNGMTSKWEKCFNDTLSKLTALEGDS IFDSLTVCSQYLKLYCFDVENLYNSNVQFLNQLVENGMASKWEKCFNETLSKLTGLEDDS ------------------------------------------------------------ IFDSLTVCSQYLKLYCFDVESLYNSNVQFLNQLVDNGMTSKWEKCFNDTLSKLTALEGDS ------------------------------------------------------------ MKECLSVLLQYLELYSFDIEKLYHASAEAVDGVRQRCASNDWRQKNQELLETIDAVSRGK MFNCLNICQQYLKVYCYDVEKLYNSNVEFVTNLEKNSNSKNWHDVYDNVLDKLPLVTHDR IFKCLNTIFQFATNFTNEIEKNFSNFFNYVKLINYKTLHKSWITNYKNLKTFPTFKENIK IFQCFNICAQYLKLYCYDIEKLYDSNVEFLNQLNKDSSSTRWEKVYEGLLQKLNTVQEKR IFKCLNIIFQFGSNFINGIEKSFNNYLNYIKLLNLKTLHRSWNGYYNNLRKFPSFQGNIK IFKCLNTIFQFATNFTNEIEKNFTNFFNYVKLINYKTLHKSWTANYKNLKTFPTFKKSIK --------------MAFQMQSNLNDLLDFRKRLTKEGP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ IFKSLNTIFQFATNFINEIEKNFNSYLNYIKLINYKTLHRTWIDSYNILKQYPPFKALVF MFRCLSIMFEFIASFTSDIENSFTKFYNHINQLSLKTLHEHWKSHYKTLASRPQFTKSVR IIESLKICQNYLELYCYDVENLYNSNVKFLNQLANNEILKNWLNYYDNILTKLSDINGNK IKRATNVAITQMKQHSQNLDKNLLNVKEYSKELNQGITLSVDLAQLRDNTRAVKLVKKQF LSQYVDEAKQIEKEVTLKSLDGKVNSKLKQIKKELDSYADQRKSIQNEIENLKNIKDMKN LSSFFNYSELTEIEDSIHRLDRELNAKLKELKKSIDECYQQRTQLISDLDDVKKNSVVSS LQKFTNVESLLENEKSVKFLNHSINNKLNKIKREIDANSNFRDTITRNIDQLRQQFTPNE LQAFVDEESLREKQNAITDLDKKVNDKLNNVKINMDNNSKCKDDVGVHIQSIRREFTLDE LQKFINIESLLENEKSVKILNHSINGKLNKIKREIDENASFRDIITVNIDRLRQMFTPNE LQKFISIESLLENEKSVKFLSHSINNKLNKIKREIDENSNFRDTITMNIDQLRQQFTPNE ------------------------------------------------------------ LQKFINIESLLENEKSVKILNHSINGKLNKIKREIDENSNFRDTITLSIDQLRQIFTPNE ------------------------------------------------------------ LVQFVDLEEMSEAEERLRELERLLSKKLSLFRGALDENHAIRQEIANHIKEVGTRYQDNI LSQYLNKGELENDYKLLCECSRGVNTKLCSLKDQIDENYKFRQTIGSASNELKLTFQEDK LSDFLEVDRLQSSADYIEKFLPLIVNKLNELKQVIETVNEEKLTVDKFIETSRNESISNF LSDFLDRRELEREHDKLLKANRVVSARLRQLKDQIDSNYNKRRTISAAFSGLKSRYEEPA ISDHLNTSELEKSSSFVSKTLPLVINKFNEMSASINSVNDDKVNVDKLIESLRNESIENF LSDFLEVDRLQSFADYIGKFLPLIVSKLNELKQVIETVNEEKLTVDKFIETSRNDSISKF ---------------TLFRTIANIQLRMVNFRTAYKSLAEEQRSE--------------- -------------------------MRMVNVKTEMRKLAEDDAS---------------- --------------------------------MVLTVHNYEKDSVDKCIESLRKESMNNF LVDFLNHDKLLEAANYVSSNLPLVVSKFNGMSETINSVGEEKLTVDKEIESLRNGSINEF LADMLNYDALVEASQFVERNLSTVIDQFNQLSATINEVNKSKIDIDGEIQVLRDESIAEF LSSYLNKNELVSISSKIEELDQRVNSNLKKFKIVIDKNIDLRNNINKEISSLSEKITPSS LNDWLDLQQLQSIVVEFKADFPSCMDKLQTLEQDLAQLSKDTQTLVNSTDVWIGGT---- DDN-HEMQKSFDSIADTVRKASRDILDKDDALQEVVPVMIDIQKKVKTLLTVSQALYENM DDMDNQMVERFKEMATEIELVSNQYKEEASKDASKEKFETFKSVHVPKLQTISQAMFNKA SKYEDKMAASFKDLVSDLRSRSRNVLDKEAEEGLNEMLEKDKKNSIKSLFTISQALYSQT SKYEDTMLSKFNGLVETMKSRSREVLNKETDESVKDMLIDDKLNATKILLTIAQALYSQA SKFEDQMAESFEVLVSEMRTRSRNVLDKEEEESMNVMLEKDKKESVKTLFTISQALYSQI SKYEDRMAESFEVLVTEMRSRSRHVLEKESEESINVMLEEDKKNSVKSLFTISQALYSQT ------------------------------------------------------------ SKYEDKMAESFEVLVSEMRSRSRNVLDKEPEESMNEMLEKDKKDSVKTLFTISQALYSQT ------------------------------------------------------------ SNYEAQILGNFKDMVKKVKEDTRTILDLDTTKSAVSLFKEMKSTAIPALYTVGLSLFTQA SKYEDNMMAKFSEMVKKMKEESHEILNQELVDGAIDIITENKNSVVPKLYTIAQALYTQA KNV-SNVLSQLQTESQQLTDDIENLHYKNMDE----IYRLHRDKLSISIYNNAKDIYKNL SKYENHMIKKFKEMTAALKDSTHDILERASDDEVSSIISENKNSTIPNLFTIAQSLYIQA KDYSEDIIKDVSRLSQLISHDIDKLSTNVSIS-LDWVYRIHKDEISPKIFDKATGLYKIL KHV-LNMLHQLQAGLQQLTDDIDNLQYRNTDE----IYRLHRDKLSVSIYDSAKDIYKNL ----------------------------------------------------------QI ------------------NDQPEDVGSENDEE---------------------------- SEL--------------IRSSSLKAIALASKQ-----SSSNSRDHSKEIFTQTEKLYNAL KDV-LELMAKIYSLSRSITNDLEQVSNNDSIK-LDEVYKEHKENYSPLLYDNAVELHNYF ASLSESLVEDIKSIGTAISTEIDSIASSESRV-LGDIYTKHVESS-KKLDEKYVQLYNDL EKYEETMLEKFTELVKNLRNDSKVILEKDENENLAKSLEKDKKVTVTNLLTISKALYSQA ---------NSDVLCNEAVGILRKLSELTSGD-------HVTNEAVKSVQNCQSQILDLH HELLTHKRNFQIQIIVKLGQIAWIQLQISELKQYLLNDCNADLTLYKDLEVEFAQIEDYP STNLDTKATVQQKLQQLYLSVAKSQMSVIMVKSVLTKDVKTNMKFLKNEELKLSQVLDLP EELINLKKSLQMHAIVTLGNIAFTQMEILGIKKLLLNDCNKDLELYKKYEVEFAQVEDLP EQLFQLKRSLQVKSIIIFGQIAFIQLETLKLKKILLSDCNKDLEKYQKYEIEFAQVEDLP GELIDLKKSLQKHAVAILGNIAFTQMEILGIKRLLLNECNKDLELYKKYEVEFAQVEDLP EELINLKKNLQKHAIVTLGNIAFTQMEILGIKRLLLNECNKDLELYKKYEVEFAQVEDLP ------------------------------------------------------------ GELIDLKKNLQKHAVVILGNIAFTQMEILGIKRLLLNDCNKDLELYKKYEVEFAQVEDLP ------------------------------------------------------------ SKCMETKASLQREMLVILADIAVAQVNIVDAKNSLLQQVNQDISALHTTEQQLLRVSELP SDSLERKKTLQECLIRTLGQIAFVQIHILDIKESILKECNKDLEFLQEYELVFSQVDDLP NDLQQFKNKLTKASLKAFNTIANLQMKMVGVKTEMKKITTEDISNVKKYEDYLSLTIDLP EESLGKKRQVQDQIIGLLSQTAFVQLQILEVKKVLLRECNDQLESLQESELFLSQVEDFP QNLYLFKNKIVDESLSIFGKIANLQMRMVNIKNDLRILTNADINNIKSAEDYLSLTIDLP NDLQQFKTKLTKTSLKAFNTIANLQMKMVGVKTEMRKITTEDISNVKKYEDYLSLTIDLP GRQADKQPSSANDSIKNIADI-------------------------KIHDDRLTLVKDLP ------------------GKVSYET-----------------INKVKKHEDYLSLTIDMP ESLATFKRKISREGLRIFQNVAKMQMKMVEIKSNMKNFMKDNIAKVRQAENLLSMTVDLP LGLRKFKEKLTKQSVSIFNSIANLQMKMVSIKSNLKTLTTPSINTIKKYEDYLSLNIDLP TKLDQFKDKLAEKGTALFRHCARLQMQMVNVKLALNEFDSRKVQEIKKKEEYLSLTIDLP NDISEIKSKLQVDSIKLFGQISFIQIETLNIKKLLLNELNKDLEKYQGFELKLAHVQDIP KALSKAKFQTVQHSQKVLQSISQLQSRSTKLKPKLTHIGSE-LTKYEEKRVQAMKQVDVE LIYGLYLVEKYRRQVWKCGMAKNMISISNDIKERSAAELTTRKNWYKNFGELSKPFNEDL MCYGLYLIELYREQLWTDRYSQLRQQHESSLQHLLDDEVRQRNSWYKDFQWITRFLDVDS LIYGLYLMEKYRRLSWFQQIVSFVSSFDQDLELFKQNELQTRSRWIKNFGSIATVFCEDL LVYGLFLIESYRIQSWYYQMLLDLMDFAKSLETNLNSETYKRERWKQKFRSLTNLFKDTS LIYGLYLIEKYRRLSWFQQILSFISNFNQDLELFKQNELRTRNKWVKNFGSIATVFCEDL LIYGLYLIEKYRRLSWFQQILSFVSSFDQDFKLFKQNELQTRSKWIENFGSIATVFCEDL ------------------------------------------------------------ LIYGLYLIEKYRRLSWFQQIMSFISNFDQDFELFKQNELRTRNKWVKNFGSIATVFCEDL ------------------------------------------------------------ VVYGLYLIELYRRQHWITGLDRYYSEHTKEIQSVLQRELVFREKWSSDFSSYSEIFQWQD LVYGLFLIENFRRNLWFEQVKS-------------------------------------- LIFGFSLIEKRRQFEWYDFYSKIVNNVSEQLSTIIEHEKVFRGIWLKKFGTLLSLINDDP ILYGLNLIEQLRRKSWGSKLQALDCKVCQEFQIIGDAEEKYRQKWNETFRQFAKFFNLSD LLFGFMLIEKRRQFEWHEFYSKIVNNVSEQLSVIIDHEKIFRKLWLKKFGNFLSILNSKD LIFGFSLIEERRQFEWYDFYSKVVNNVSEQLSTIIEHEKVFRGIWYKKFGTLLSLINDEP LIFGYCLIERRRQYEWNDFFAKIVDNVSEQLASIVDAENNARKLWNLRYGQQLRELLLQQ LLFGFALIEKRRQFEWSDFYSKIINNASEQFSTIIEHEKLFRGIWWKKFGTFLSLIDNEP LLFGFMLIEQRRQYEWFDFFTKVVSNVSEQLMIIIDHEKMFQKLWIKKFGAFIKLLNVKN LLFGFVLIEKRRQFEWYDFYSKIVNNVSEQLSTIIDHEKLFRKIWLRKFGNFLTLLSDET LLFGFAIIEMRRQYEWYDFFASAVSNVTEQLQVIINQERVFRKIWAKKIGSFLSILDSLP LVYGLYSIENYRRESWVLQINYKHLDFNKSLKTIVEKEKSTRNKWVDNFGSTAVYFTEDM FVYGCVLVEMLRRTVWSQSGGE---------NGSVKSEIGTRVAWKKQFQDTFPFVDILN TKLDEISKLMNSDSQDLRRKLEDVIKSFIKNMHDLGLSKETTQVLEQSFKE--------- LLPSSVYIPSISDHK---QVTLSQIKDYINQLASLNLGEPTINLLKSKVSQ--------- LSYYSISSPPNEKDKLYHQELSQVIDNYMVQIKETNVPEAIIDLLSKTLTE---AKRFHI DNSEFFKDGISNVTTNYKLKFYHNVEVYLTQLQTVDVPEKFFMILSQNFNT-------IK LSYHSHTSPPNEDEENYRVKVSQAIDNYMTQIKETDVSEPIIDLLSKTLFE---TKRFHI LSYHSLSSPPNNEGKRYHVKLSQVIENYMAQIKETNVPAAITDLLSKTLLE---AKRFHV ------------------------------------------------------------ LSYHSHSSLINENDENYHVKVSQAIENYMAQIKETNVSEAIIDLLSKTLFE---TKRFHI ------------------------------------------------------------ DK-PQLAKLFSNASPDIG-----TIQTYIEMLARCDVAEDSQTLLKKTLSEVSR------ -----------------------------SQLR--------------------------- LTPNIDVTLVGNRQNNFSKIERDDIINYISLIEATNMSKNFVTLLNKNFKDLIAVTKVIS QDYRALYNSNPGKFK---EIKAENIERYLIQLSQHEVAPESLALLQKNLDNANN------ ENPSIDVTLVNGNAETFGQVERDDISTYINALESNAGPSKFSELMKKNFQDLIKVTKMVS LTPNIDVTLVGNRQN---KIERDDIINYISLIETTNTPRNFVTLLNKNFKDLIAVTKVIS QQYTVLLSRIPFVDINVPDVQRDDILKYIQLIEESSFGQTCAEQLRKRYSEMKAITRGVS VAPHIDVTLVSNKQDSFSPIERDDIIKYISIVESSRVSKNFVELLNKNFKDLINVTRIIS DAPSVEVSLSNGYSEFLGVIERDDIAHYIESIKKFTNSSKFASLLAKNFKDLMIVTRVVS PTPNIDVTLVGIKEETFKQVERSDIVNYIAFVESSKASKNFVELLNKNFRDLIRITRVIS SDPSLDVTVVKGREDDIQ---REDIDKYIKWVGSIDAGKNFSMLLERNFEDLIKVTKAIG DTAKGNQSMIKKLEESHNVF----IETYIKEVEDLDLDKDVIELFKRYLAV--------- EQEDLTIDTISTSSP--SVIARPVVTDYISQVSSKEVRNNLESLLGGVTGSAAA------ ------ASNCSQIDVTYDHRRINNEN-DLIKRYKIRIRKLESLLHEQGYSSISKWPSGVL ---------AELTGLHLPTDYALSKD--IIEGYKARIKKLEHLLLDAQFHQYDSWPAGIL IYSNFKTHNFDSSNNTLEESTMLKSD-ELVKGYKTRIKKLESLLHELQYSDVNHWPLGIL HLPTLTTLSPSSSLSSPDMTNQQISE---LDGYKVRIKKLESLLHESKYLRYEDWPSGI- IYSNFKNNNSNGNSISPEGSIALKSD-DVVKGYKTRIKKLESLLHEFQYSDIGHWPQGVL IYSNFKINNSDTNNTTPEESTVFRSD-DVIKGYKTRIKKLESLLHEFQYSDIDHWPQGIL ------------------------------------------------------------ IYSNFKTNNSNGDSISSEESIVLKSD-DVVKGYKTRIKKLESLLHELQYSDIGHWPQGIL ------------------------------------------------------------ ---------FQFIVKSPLAGSVSKDSNEVIEGYKNRINKLELLLHSTQFSNTSSWPTGVL ------------------------------------------------------------ SLSTYTTNSKSKSSHEEGTEEEIDFDLNLIKGLKSRIKKLENLLHQQQFKNLNNWPVIRD ---------QALRLKAPGGTDVTSKDAEAIKGYQSRIRKLESLLHDAKFSNISSWPSGIM SLSSFTSPVANEIKNNDKLLANLKDEAELVKGLKIRIRKLENLLHQQQYKDLSNWPVTRD SLSTYTTNSKLKSLHEEGTDEEIDFDLNLIKGLKSRIKKLENLLHQQQFKNLNNWPVIRD SLRHIKLSSTDGSGPGDGSRSDMNVNYTVVRELKSRINKLESLLHQYQYRNINSWPVTRD SLSTFTSFTKSKHLADEETTDEVIDFLNLIKGLKSRIKKLENLLHQQQYRNLNNWPVIRD SLGSMTSVNTNSMVLRNYQEGSKEFEINLVKDLRQRIRKLEDLLHQQQYSNLSNWPVIKA SLGTYTSLSKLKILLKEDEEGEIDFDLNLIKGLKTRIKKLESLLHQQQYKNLTSWPVTRD TLSSY----TSPENIDAVQPNDKKEDQDLIQGYKNRIRKLENLLHQQQFKDLSTWPVIKT ---------AQGFVIEQPSTKNIISDGELINGYQSRIKKLELLLHSARYSNVESWPTGLL --SLFRNGSSLMAERAPISSATNADD--KIRGYEARIRKLEDLLYKQRMQDTSRWSVSP- NHTDPNYFADNVSPAGRSLLVSSSL---------GLEPSASLKTDAEMFDEIGDLSEKVT NKETVQMFRNSTVSTKLQQS-----------STFDLPSSKQQHESNKTFEEFQNLQKDIS NTH-IKPFHSNIPSVNKKKFLSTSLEPSE--VNNGSIPQIENHRVQELESNVQDLLQQIQ ----KSPSMSSKNNIFRNNLSSINLAMSTNNMNLTLQPDNEQQEEIEQYVQINELQDIIT NTH-LKPFRGSATSINKKKFLGASLEPANISVNIDSVSQANNHQIQELESNVDDLLHQLQ NTQ-LRPFRGSIPSINKKKFLGASLEPSNISVNNGRTSQFNSHQVQELESNVEDLLQQIR ------------------------------------------------------------ NTQ-LKPFRGSVPSLNKKKFLGASLEPSNNSLNNGSIVQANNHQVQELESNVDDLLHQIQ ------------------------------------------------------------ NSNSLNVFHNNIASINEKLLLSD--------YKSRDSIMSGKSNEKELQSQLVELQKQLE ------------------------------------------------------------ NRQSIQPTVVSPARTNPTQLLSRN---PSTTENTTTNIHNNHQQSEVLDSLNNELQTKNT NNKSLNAFENNVPPINLKMSLLLA----------DGREERSITANEEVISEVQKLKYELE GKFSQKTSTSSNSKIDPTNLLQRRLPLKLGHKPTTSQQSNHLDVSTTIDKENNELTNENL NRQSIQPRVVSPAKTNPTQLLLRNPSTKENTTTTNIHNNHHQQQSEVLDSLNNELQTKNT NRMSSKQIASQTPLTDPTKLLSRNPSTSRNGSQPSSAHSQEVQGAHGLESINSDLKATNE NKMSIQPKAVTPPRTDPTQLLSRRASTKEAATTGAGAGASTIKQSQTLDSSNNELQLKNE NNMSLLTSHPSPMTSDPTKFLKEKNSSIEEKEMKAKPLDASTTIDKHLDNENNELKNSNK NRLSPQKKTVTPPKSDPKQLLQKQSVPTRTSAQSAVLDSTNIDIRLELIKENTELINENS QDQSFNPKRNSGVGSDNVLVHSQHKILLQNHSSIKDESSSRTDHLK----ENEDLRKRLQ NYSNVKLFRNNVATVNSKLSLQSD-------YMGNISYGSDQLRIKELENVNKQYKTDFK ----SAGFAVVSPGQLSSEARGSSPEPTE---------------------TREQVKAREK ALEKDNKLKTDQLKITHSKLIDIEVEKAAFRETLNHLNKELARLTVNEEDQTNLLKEERL KYSELTKTLETELSTLKSQLSHMEVEKNAYRESMTNLNKELSTLLIERENFYSEMNSRSE SLKDENIQKSKEISDMRRNLSDAEVEKTAYRETLTNLNQELARLTNEEQSHKTEIFALNA DLKMNLESTTKELTMRTNEVVDLKIECKAYRETLTNLNSELSRLTETDEKEKINRVDRDA LLKEENNRKSMQISEMGKKISDLEVEKTAYRETLTNLNQELARLTNEEQSHRTEIFTLNA FLREENIQKSKDISEMKKNISDSEVEKKAYRETLNNLNQELARLTNEEQSHETEVFALNA ------------------------------------------------------------ LLKEENNQKSREISEMGKKISDSEVEKTAYRETLTNLNQELARLTNEEQSHRTEIFALNA ------------------------------------------------------------ EAKNEAKRVQQQLKTTKTQLLNGEDERTAYKETLSILNAELSKLILNQEEQKQELVIAAK ------------------------------------------------------------ ELTNQINSKNETITQQQKEMEHMKLKTEKRVDELMDEVENLTKKLELSDNHNKELEAKIT QQKLELASSREECKQLRSRVVDFEDERNAYQETLVNLNQELSRLTAEREQQMLAKNDSFS KLSNTNRTNEKLIEALNKQISNLKTVNDDQNKHHEKEVVDLKDKLSLRDAEILDLRKDIT ELENQINQKNETIMQQRKEIEDIKLANDKKVDELMNEVDSLTNKLELSNNRNNELETKIS TLLKDIAVKDQEIAQLQLQIEDMKVSHNNKVNKLNKEVENLESKVTAKNAQIRDLTDEKT ELYEQVKSKDEKIGQLEKEIESMKIEHQKKIDELMKEVESLNKKLATRDSRISELESKIS QLHESNLILKEQISKLQESLRLEQQKNENLSSQYEKIREEHNAMVTQLAKDKNELVNELE ALHQSNDESQKLIKDLRKEIEELKAINASHRQEADKLVENLEKKVEQRDAQVSKLKEDLS ELQIGGERRVEAKVPFEASLSGTKILAQQNTEIL-AQKKALEMKVDSQLQVIEKI----- ALTDENKLLKDKVTKFNTDISDIQIERNAYKETLTKLNEELSRLTSIEGDFEKHKGEKEI AEEEARKAEEERLARDKAAAEALQSKVD-------QLSQSLLHTENEKNDLMANLASMES RFKKEMTSVTVVNQNLMNNLDALQKTFEDVELENAHLKSKLKELQQRQDQLIEDSANEKL NFKKHLGSLFEQNEELVRESEESRRKSEDLNKMKEDLLVNMATQEVQAEQERASLQEEVE SFKKHLNDIVDHDNEKLININKLTSDYDDVFKSRERLQVEINEIRKTHKEEIDSFKADIE IFKKQMIQMIEKNKTLMSEVETWKGKCTELQETNDK-SVEIEELKKMHSLELGSIRQQIK SFKKQLNDIISQDNE---KIEKLTGDYDDVSKSRERLQMDLDESNKKHEQEVNLLKADIE TFKKQLNDIIAQDNEKLAKIDKLTNDYCDISKSRERLQLELDEARKEHEEENNSLKAIIE ------------------------------------------------------------ SFKKQLNDIICQDNE---KIEKLTSDYDDVNKSRERLQADLDESNKKHEQEVNLLKADIE ------------------------------------------------------------ DFQEKLDVSMRQVNDLLKQVNFWKSKCGDLDKIKQDLLANMATKETDFNNRCTDYERNIV ------------------------------------------------------------ EYTQKATSKTKEIADLNKTVSNLRSELGDAMHMKNDLLSNLSSKEAEFTKERNQFNNDLK TLKAEMNTIGKLNSSLLNELDEWKDKHEKLDKLKDGLLANMAKFENDFVKERSSLQNEID RLHDVNEGFTEEVTKLNEKIATLQSDINDVNAMKKDLLSNMASKETDTINHRISLEEEIK EYNQTVAATSKEVADLNKNVSNLRSELGDAMHMKNDLLSNLSSKEAEFTKERNQFNNDLK AEANLVADLKHKLEQLTKLVSALRNELNDSSKMKNDLLSNMSSKEAEFALERNKYIEDIA HFTDLTTTSSKEVSELNKTITSLRNELNDAIHMKNDLLSNLSSKEAEFTKERNQFTSDMK SKNRTLENNASSNRDLEQEISDLTAELSDLRIFKTELYSNMQAKSAEFTNERNELEKKIK RVMEINTTSDKEIIALNSTISSMRNELNDTVVMKNDLLSNISAKEVEHSKERNGLENEIK --QKESSEKDNEIFALKKQIQDLTGEANEFYARNEELKKNAEVKYDHLVQELNEEKDKSS ELKIKIDGLVDSNKTLLNQISDLKIESKELESSNRDLLAQLNQKREEHKVLEDSLKEKLK DFSRERRCLVQEISELKLRVEELEEQVETAAETSIERHQRADQ--------------ETE EIKSKYEKIKEKDENMGQAFAVTNKAISGEQNKTESDIIHSSPYPEAILHELFDIFSTNI SLKKDLNQ----------LQISKSKTIDA----------EFINFNKQLEKTLYDVFQGSI RLNGQITILEKSESEAKSSLIEKIENIDTIPFSNDTKTNDTVS--TQALQKAFDIISTNV KLQDKISSLETQKVSTVQLSEDVKETMDVVSTEEDMGSKEESVIDVATVTELFEIFSSNI RLGKQIVTSEKSYAETNSSSMEKGEKFETIPLAEDPGRENQISAYTQTLQRIFDIISTNI RMNGQFTTLKNNDSEIKSSSIEKIEKIETTPSSGGPDRNDLVSFSTQVLQKIFDIISTNI ------------------------------------------------------------ RLDRQLVALEKSDAETKSSSMEKSEKFETIPPTEDPNRKNLVSVYTQALQKMFDIISTNI ------------------------------------------------------------ ELQRQLSE-KCDATNERSVTSTSAD----VPGETKEYIESLKEVNRRLEEDMFAVFAGNI ------------------------------------------------------------ ALQLKLDEINEDYENLMELTQAKQKKHDLIINDLNNVIINLMNDIKKTLLSVFEYFLEYC ELQREILSLKAANDELVNNQMA-------LASLKKEETPEITNNEAEQLSRMFEIFASDI KLHSKIEELTEDYENLMDLTQSKHNNLDIMVNYLNNMIIHLLSSIKCLVEQQFETFIEFC TLQLKLDEVNEDYENLMELTQAKQKKHDLIINDLNNVIINLMNDIKKTLLSVFEYFLEYC RWKAKFEEASDDYENLMELTQTKQLKHESVVDDLYKTSINFMTIIKFLVGKLYDNFRETC NMQTKLDEVSEDYENLMELTQTKQKRHDLLINDLNNVIINLMNDIKRVIQEIFQYFLEYC DLISQLERSTDDYENLMEITQAKERHFEATIASATDVIKQLFLRVIQLMRRCYKFVEEFS TLLAKVDELTEDYENLMEITQSRQKNADLLVNDLNNIIIKLMNDMKRLAENIFEYFLEFC SLSSELDA--------MKRGANDRKDAEKAIAELTSVASDLYGKLVDHSHITFDYVLTLS ELTEKFEAIKAAKEQNMKESMEQQTEQSATPTSEDMHSLDEQSPESQLLKKLYEIFSSNV ELEQRLKA------------------MTLAQNTVDDENSRLKITLQDMSQRLYTGYKRNC YILENIGLLLTETSGKFEIKRVKGLKKGLSQSSPI--DGVINSVVYKNIRAQYE---QLP FILASIGLLLSKDDGNFQIVRVKGLRKDLDSSLADMNSSMAKSVIAQEIKSTFE---SIK FILENIGLLLTYDNNNIQIRRVKGLKKGITQSLDTADNSIIKSPVFQKLKDEYNLVKSVN TILENIGLLLTYADRSVQIKRVKGLRKGAMQSTEA--DRFIKSSVFHEIQSSFTRIQ--E FILENIGLLLTFDNNNIQIRRVKGLKKGTAQSLDAHDNSLIKSPVFQKLKDEYELIKVAN FILENIGLLLTFDNNNIQIRRVKGLKKGAAQSMLDMDDSMIKSPVFQKLKDEYNLIKCTN ------------------------------------------------------------ FILENIGLLLTFDNNNIQIRRVKGLKKGTAQSQDIYDSSIIKSPVFQRLKDEYDLIKFAS ------------------------------------------------------------ VLLENIGLLLSRGPNKLQIIRVKGLRKNIDDS-PVINSHMVKSTVFQDVKNLFD---ELQ ------------------------------------------------------------ LVLESMGLLLVKEDEIYKIKRVKGLKSKKSIGMSIISNGTPSSKVIEEIENEINIVNDSV YILENIGLLLSWGDSQFQITRVKGLRRGVTSSTDPKMPTIIKSPVFQAVKSAWE---SSE FILESMGLLLIKEHDEYKITRVKGLKSKRNDKIVSTMGNMPTSKVVDDINKIIGWVDVEE LVLESMGLLLVKEDKIYKIKRVKGLKSKKTIGMLIISNGTPSSKVIEEIEHEISIVNDSV VILESMGLLLVKEDKIYKIKRVKGLKSKKLSNSVHSTDNIPNSRVVEEIKAKLNWLDTAC FVLESMGLLLVKEDSIYKIKRVKGLKSKRSSSISVMSLDVPNSNVIEDIEKEMSWVGDSV LVLESMGLLLIEEQMEYRIKRVKGLKAKKADHITESKSHGIHSLVVEEIAKSMKWVEDEI FVLESMGLLLTMDGDVYKITRVKGLRSKKTVDTLFISIEKPSSKVIDEVDKSMSWVTEEE YILEKMGLMLTNEGNVFKIRRVKGLRSRKQDG--ENSQTDVGSPVPGAIKNMMVWSHNVN FILENIGLLLTFDEDNFQIRRVKGLKKNLNQ-LNEIEMP-VKSDVFSEVKTLFS---NYK VLLESLGLQAQKEDVSFDIHRVKGLRKKHRGK---KGEKTEKDSESDSTDSALYWATKTT NDNNISNCELFISSVKKIYENLFESAVINRFKDIETLAKRLTKENKSKRILIDLYQNERL DQIDYKPHENFITYIEKLFGNLFETSVIRRFNDIESLAKKLRKENKNKKLLLQKSARDKI GADKDAQQSIFVRHIAQLYDNLYEVAVIRRFKDIETLAKKLTKENKIKRTILERCQREKV GNDKMENRVFFLNNIETIYSELYETAVIRRFKDIEFLAKKLTKENKLKRSLLEQYQREKL GSEKDTQQSIFLGNITQLYDNLYEVAVIRRFKDIETLAKKLTKENKIKRTLLERFQREKV GADKDTQQSIFVENIAQLYDSLYEVAVIRRFKDIETLAKKLTKENKIKRTLLERCQREKV ------------------------------------------------------------ GVDKDTQQSIFVENITQLYDNLYEVAVIRRFKDIETLAKKLTKESKVKRTLLERFQREKV ------------------------------------------------------------ LSQGVNDQLHFVSELERFYEELFQTSVIKRFTDVENLAKKLRKENKAKKSVIERHNKDKI --------------------------ILRRFQN--------------------------- VDRYNDQSMKLISTFNQLFKFFFLNAISKRFRDVEGFAKRQAKDNKLKEQEHRKLVNSKI SCKSLSMQKELMASMNKLFKNLYESSVIKRFKDIEALAKKLTKENKFKRGLIDNYQREKI TNKFNRQSLELVKLFRDIFKSFFLGAITKRFKDVEGFAKKLTKENKSKAHELSQLINCKI VDRYNDQSMKLISTFNQLFKFFFLNAISKRFRDVEGFAKRQAKDNKLKEQEQRKLINSKI NTDVGDQHLENAKKLRTAFDEFFVNAILKRFKDVEGFAKKISKDLKAKDQEINKFHRNKI VDRYNDQSLKLIQVFNDLFKFFFLNAISKRFRDVEGFAKRQTKENKVKEQEMKKLMNNKI INEYEKEATRLSHLFEKYFSDFFLNSIAKRFNDVEGFAKKLTKE--IKSKTQEKSVKKRI SNKFNSQSLKLITIFNEIFTAFFLNAISKRFRDVEGFAKRQTKENKIKEQEIHKLVATKI PADMIESAKEIINVCRNKMDEFFSNAVVKRFKDVEGLAKKLAKEKKTYETQLQKLTSAKV ETFDSRSYISLLSKINQLYDCLYETAVIKRFEDIELLAKKLAKENKAKKNLFEKYRCERI PDSFESSYRTFLARIFLDYD-LYVEKVAKRFEDLEHLARKLQKEARNYRTMTQQLDRSKI AVKDFRVNDLALFLPTKPNVKHPWAAFTAESSRYFLKDENMVTDNKEWFIGKITDIQRQV TIYNFQPGDLALFLPINSKANRPWAIFTATDIKYVLRNSTELLKDREWAMGRISALEKHV TLRNFQIGDLALFLPTRSKLMRPWAAFTAENTRYFLKDEKGLTKGKEWFVGRIVTLEHFV TLKNFEIGDTVLFLPTRPTIKRPWAAFTAENTRYLLRDVQEQTKGRDWAIGQIKTMQKFA TLRNFQIGDLALFLPTRNKLMRPWAAFTAESTRYFLKDEKGLTKGKEWFVGRIVTLEHFV TLKNFQIGDLALFLPTRNKLTKPWAAFTAENTRYFLKDEKGLTKGKEWFVGRIVTLEHFV ------------------------------------------------------------ TLKNFQIGDLALFLPTRNKLMRPWAAFTAESTRYFLKDEKGLTKGKEWFVGRIVTLEHFE ------------------------------------------------------------ TFRDLKVGDLALFLPTRNKSTP-WAVFTALGVRYFLKDSEELVKGKDWFVGKIQSMEKYT -----------------------YCX---------------------------------- SVNGFQEKDLVLFLPTRNDKIQPWAAFNIGAPHYFLKTEQ--TKNKEWIIGRVKKITEYK TIKNFQVGDMALFLPTRSNDKSPWAAFTAESTRYFLRDNERFTTDRDWFIGRITSVERNL SMNSFEMDDLVLFLPTRDENFQPWAAFNIGAPHYFLRVQKHSIKDKEWMVGRVTYIEEHT SVNGFQEKDLVLFLPTRNEKIQPWAAFNIGAPHYFLKTEQ--TKNKEWIIGRVKKITEHK AIKNFEVGDLLLFLPTKDHNTNPWAAFNVGSPHYFLKNGDGELNAKEWFIGRAKSIVEYR TLNGFQENDLVLFLPTRDEKFQPWAAFNIGAPHYFLKTNE--IIGKDWFIGRVRKILEYQ AVNNFSEGDLVLFLPTRNEDIPPWTAFNLDAPHYFLDISTTNIGNEEWYVGRIISMEERL SMNGFQIGDLVLFLPTRNESIQPWAAFNIGAPHYFLKVDDERTKNKEWMVGRVESIEENK TLSNFQTNDLVLFLPTRQEVIQPWTAFNIGTPHYFLKSQP--SVEREWIVARIVSIVEHT TLKNFEVGDLALFLPTRHNLEKPWAAFTAETARYFLKDPENIPNNREWFVGKIMHLQRFV ALNRFKVGDLVLFLPTRPSRQPPWAAFNVGAPHFFLKQKPRELKDRDWLVGRITGMEERV VENSTNNPFKLPKDTVWYLISAEMISI-MFKRPGNYFFIVPWIAFIPWYGMLIAMLICWA VGDDSKNPFKFPRNTVWYEVDAFFNLD-MFPRPGNYWFIFPWIAFIPWYGMLIAMLACWA ADSSSNNPFRLPKGAVWFQVTAVVVSYFEFKRPGNWLFIVPWIAFIPWYGMLIAMLACWA VDGTNFNPFKLQKGTIWYQVTADIITSLNFHKPGNYFFILPWVAFIPWYGMLIAMLICYA ADSPSNNPFRLPKGSVWFQVTAVVVSYIQFKSPGNWLFIVPWIAFIPWYGMLIAMLICWA ADSPSNNPFRLPKGAIWFQVTAVIVSYLQFKRPGNWLFIVPWIAFIPWYGMLIAMLICWA ---------------------------LEFKSPGNWMFIVPWIAFIPWYGMLIAMLICWA ADSPSNNPFRLPKGSVWFQVTAVVVSYLQFKSPGNWLFIVPWIAFIPWYGMLIAMLICWA ------------------------------------------------------------ VNGDSRNPFKLPEGMVWYEVVASCTKEMGFPPPGNYFFLVPWIAVIPWCGMLIAMLVCWS ----------------------------MFKKPGNYFFIVPWIAFIPWYGMLIAMLICWA VTELESNPFQLSVNVTWYLVEADEE--PLIRFQVIHYYLIPIIALIVWWGMLIAMLSCWG TVDSTSNSFKLPRGTSWVQVTAEFVTAFKFKKPGNWFFVVPWIAFIPWWGMLVAMLACWA VTDKDANPFHLSTGVVWYVVDAKEEIFPLLRFKIIHYYIIPFIALVVWWGMLIAMLSCWS VTELESNPFQLSVNVTWYLVEADEE--PLIRFQVIHYYLIPIIALIVWWGMLIAMLSCWG VTEFEANPFHLSIGVTWYMVEAEAERKPIVRFQVIHYYLIPIIALIVWWGMLIAMLACWG VTELDINPFQLSVGVTWFMIEADEEKTPVIRFQVIHYYLIPIIALIVWWGMLIAMLACWG VTDKDENPYHLSAGTSWYMVQTK----WYLQFTKFHYYLIPIVCAVVWWGMLIALLACWG VTDLSSNPFQLSVGVVWYLVEAKEEHFPLLRFKKIHYYLIPVVALVVWWGMLVALLVAWY VTATSLNPYRLSEGITWFSVEAKEVSQPIFRFKKVHYYLVPLVALVVWWGMLTAMLICWG VEDHISNPYKLPKGAVWFQVTATVVSHFSIKRPGNYFFIVPWIAFIPWWGMLIAMLACWA VNGREENPFDLGQGLRWWWLEAEEE----------------------------------- AQGHPIYWFMHTEQFPVYISDIGATNLRPLFIACAGWQGLGYVITIACEYFQRLHSRLLP GQGHPIYWFMHTDQFPVYISHIGATNLKPLFISCAAWQGLGYVIMVALEYFQRIQKKYVP GQGHPIYWFMHTEQFPVYISDIGATNLRPLFISCAAWQGLGYVITVACEFFQRHSGKFLP AQGHPLYWFMSEKASPVYISDIGATNLRPLFISCVAWEGLGYALTVFAEYYQRASRKFLP SQGHPIYWFMHSEQFPVYISDIGATNLRPLFISCAGWQGLGYVITVALEFFQRHSGKYLP SQGHPLYWFMHTEQFPIYISDIGATNLRPLFISCAGWQGLGYVVTIALEFFQRHSGKYLP SQGHPIYWFMHAKQFPLYISDIGATNLRPLFISCAGWQGLGYVITIALEFFQRHSGKYLP SQGHPIYWFMHTEQFPVYISDIGATNLRPLFISCAGWQGLGYVITVALEFFQRRSGKYLP ------------------------------------------------------------ VQGHPIYWFMDGDQFPVYISDIGATNLQPLFVTCVAWQGLWYCIMVACEFFQRSSSRFLP AQGHPIYWFMHAEQFPVYISHIGATNLRPLFIACAGWQGLGYIVSIACEYFQRRSAKFLP AQGRPIYSFMNGYQNPVYISDIGATNLQPLFISCSGFQAIFFVGTLIMGFYLRKSGKIQP AQGHPIYWFMHTYQFPVYISHIGATNLRPLFISCAGWQGLGYCVTVACEYFQRRSARFLP LQGHPVYAFMGYDQSPVYISDIGATNLKPLFISCAGFQAIFFVGTLIMEYYLRTARKLQP AQGRPIYSFMNGYQNPVYISDIGATNLQPLFISCTGFQAIFFVGTLIMGAYLRKSGKIQP AQGRPIYKFMNGYQNPVYLSDIGATNLQPLFISCAGFQGIFFVGTLVVGMYLRKKHKIQP AQGRPIYSFMNGHQNPVYISDIGATNLQPLFISCTGFQAIFFVGTLVMELYLRKAEKIQP AQGHPIYSFMKGHQDPVYLSDIGATNLQPLFIACTGFQMIFFMGTLIMEYVLRKKHKLQP IQGTPKYSFMKHNQSPAYISDIGATNLKPLFISCAGFQGIFFMWTLIMEYYLRTHRKLQP VQGRPVYSFMDEKQNPVYISDVGATNLQPLFISCAGFQAIFFVGSLIMDFVLRKKHKLQP GQGHPIYWFMNGDQFPVYISDIGATNLQPLFISCSGWQGLGYVISIACEFFQRLKSNFYP ------------------------------------------------------------ YYTKHERNLIFASFVLGCIGEIALLMCSIFSTAKYHHVHISMVAIFCIFMLLSIVCLTAE FFTKHERNLVWASFVLGSIGELALLMCTIFSTNTYPRVHSSMVGIFCAFVGLSVICHVAQ YYTKDERNLIFAAFVFGCIGELGLLFCSIFTTALYHHVHIAMVTVFVVFMFLSICCLTAE WYRKDERNLIFAACILGALGEIALLMCTIFSTAHYHHVHLAMVAVFVVLMFFSVVCLSTE YYTKDERNLIFAAFVLGSIGELALLFSSIFSTALYHRVHIAMVSVFVVFMFLSTCCLIAE YYTKHERNLIFAAFVLGGIGQLALLFCSIFSTALYHRVHIAMVSVFVVFMFLSVCCLIAE YYTKDERNLIFAAFVLGGIGELALLFCSIFSTALYHHVHIAMVSVFVVFMFLSTCCLIAE YYTKDERNLIFAAFVLGGIGELGLLFCSIFSTARYHHVHIAMVSVFVVFMFLSTCCLIAE ------------------------------------------------------------ YYTKHERNLIFASFVLGLIGELAILMCAIFSTAKFHKVHLSMVGVFVSMMYFSILCAAIE WYTKHERNCIFASFVLGSIGEIALLMCSIFSTADYHRVHISMVAVFCAFMFLSVCCSAAE YISKHQPRLAIASIICAAIGQLGIVFVAIFNTKNFHPVHISMVGVFIAFCFLACVCDFTI YYTRHERNCIFACFVLGACGEICLLMCTIFSTAHYHRVHLTMVGLFCAFMFLSVCCNVAE YVSTKQPKFAIASIIFAAIGQLGILFVSIFDTNSHHKVHLSMDVL--------------- YISKHQPRLAIASIICATIGQLGILFVAIFNTKNFHPVHISMVGVFIAFCFLACVCDFAI YISHHQPRLAIASIIMAIIGQLGILFVSIFNTKNFHSVHMSMVGIFIAFCFFACCCDFGI YVSKHQPRLAIASIICAICGQLGILFVAIFNTKNFHSVHISMVGIFIAFCFFACVCNFTI YVSTKQPKLAIASIICGFIGEIGILLVACFKTSKFKHVHFAMVGVFIAFVFFACCFNFTL YVSTKQPKFAIVSIVCGFIGQLGILFVSIFDTKRFHDVHLSMVGVFIAFSFFCCLFNFFN FVSKRQPKLAIASIVCAIIGQLGILFVAIFNTNAFHRVHISMVGVFIAFCFFACLFNFFN WYTVHDRNFIFAAFIFGLLGEVCLLMASIFSTAHYHHVHIAMVVLFVILMFISVCCLIAE ------------------------------------------------------------ YFSMGRHYASIHPLAATKAWTGHIWNKFTISATLKTIWCIAAIVWAICFGAIH---DNSK YMTMGRHYAVVHPLTSSEDWHGHVWNKYTISGLLKAFWVIAAFVWAICFACLE---DRST YFLMGRHYASIHPLANSNSWQGHIWNKFTISATLKTIWLALAVVWAICFGAIN---DRSK YFLMGRHYALLHPLADHTRWEGYVWNKFFISGLAKAIWLVFAVVWAICFGAIS---DDST YFLMGRHYASVHPLASPHFWKGHVWNKFTISATLKVIWLTLAVVWAICFGAIN---DRSK YFLMGRHYASVHPLASPHFWEGHIWNKFTISATLKVIWLTLAVVWAVCFGAIN---DSSK YFLMGRHYASVHPLASPHFWEGHVWNKFTISASLKVIWLTLAVVWAICFGAIN---DSSK YFLMGRHYASIHPLASPHFWEGHIWNKFTISATLKVIWLTLAVVWAICFGAIN---DGSK ------------------------------------------------------------ YLSMGRHYARLHPLAGSAARHGHVWNKLTVSGTVKMVLLFLAAAWAICFGAVK---TPSI YYMMGKHYAQLHPLADPQEWVGHRWNKFTMSAVAKTIWLITSLTWAICFGAID---DSSV SFIFGTNPSKLDPVHDQVVFGTSKFDLYFVSFMLKLVWLFAAVAFAICFGVYMKNDQNSK YLMMGRHYAQLHPLADPDAWVGHKFNKYTISGIAKAVWLALALAWAIAFGAAE---DNSI --SNGPPSTLVQ------------------------------------VPYNELDG---- SFIFGTHPSKLDPVHDQVVFGTSKYNLYFVSFMMKLIWLFAAVAFAICFGIYMKTGQNSK TYIFGTRGDQLDPVHRTTVFGTSRRNLYYIGFWAKIIWILAAICFAAAFGYYMNTGNDSR SCIFGLNPKKLDPVHDQVIFGKSKTNLYFISFVLKLIWLCAAVAFAICFGTYMHQDEDSK TFIFGNFPQRLHPNHEKVIFGKRRWNLYMVSFFLKIIWVIFAIVFAVAFGALMNQGYKSA SFIFGNYPSRLSPDHERVIFGSWRWNLYMVSFWMKFVWLFVAAAFAICFGYFMKDGNRNL SFIFGNYPHRLSPNHEKVIFSNHRWNLYMVSFWFKCFWLVCAAVFACFFGAYMKKDKNSK YASMGKHYALLHPLANPETWSGHIWNKFTLSAAFKAVWLTLGVVWAICFGACG----DSI ------------------------------------------------------------ SACFEWLLAFWFGIIFMIISADFYLGSLYKRSKYFHQIETFAGYYKYDKFAGVRDYESND TACFEWLLAFWFGLYFIIVSVDWYIGGRYTQSKYFHQITITENYYKYNQLNAL------- SACFEWLLAFWFGVIFIILSVDFYMGGRYRQSRYFKHVESFSGYYKYDKALGLYHSEEVL SACFEWLLAFWFGLLFIIISVDFYMGSRYKDSRYFNRIESFAGYYKYDQMLGAVDVSIQM SACFEWLLAFWFGIIFMILSADFYLGGRYRQSRYFNHVESFSGYYKYDKALGLYHSEDVL SACFEWLLAFWLGIIFIILSVDFYMGGRYRHSRYFNHVESFSGYYKYDKALGFYRSEEVL SACFEWLLAFWFGVIFMILSADFYLGGRYRKSRYFNRVESFSGYYKYDKALGLYRSEEGL SACFEWLLAFWFGILFMILSADFYLGGRYRQSRYFNHVESFSGYYKYDKALGLYHSEEVL ------------------------------------------------------------ SASFEWVLAFWLCAYYVIVSVDFYMGSRYKESKYFHQITNFSGYYKY----------DQL SACFEWLLAFWFGLLFIIISVDFYLGSRYKCSKYFNQVESFEGFYKYDNLVPAHRHETA- SAIFEWLISFWYGLLLVMWSMDLLPSALRKYR--FKHPDMYPRYVQYNVNNNKANDYESQ SSCFEWLLAFWFGVIFIIISIDFYLGGRYKYSKYFHQVTSFQGFYKYDRLVPMPHMEHV- -------------------------ANNYRN---YNQV---------------------- SAVFEWLISFWYGLLLVMWSMDLLPSALRKYR--FKHPDRYPRYVQYNNKNKANDDYESQ SARFEWTICFWYGLLLVLWSVDLIPSAVRKYR--ARHPEIYQQLAKWDAADGNDPVMQNQ SAVFEWLISFWYGLLLVMWSIDLIPSAIRKYR--FKHPHIYPRYQNL-------ESQWEK SAVFEWIICYWYGFLLVIWSLDLFPSAVKSYR--LHHPEKFD--TEF-------IDNHKI SASFEWSISFWYGILLVMWSIDLFPSACKHYR--VRHPEEFD-----DS-----LNDDKH SAVFEWLISYWYGLLLVMWSMDLFPSAVKHYR--VRHPEKFEHVKNETYSPPPQPTDTTL SACFEWLLAFWFGLLFISISVDFYLGGRYKYSKYFHQVQSFHGYYKYDKIISSSSSSEST ------------------------------------------------------------ SSGKYEDSDRTETMVQEDSPVEA------MVNGYSLLDLVRDIGNGHL--------GVLS --------------------------------MDHFFG---ALKAGDF--------SVLD PSDDTADATTTETAPSNDHGNAASNESF-------------------------------- TGDDDQSFDKAVTNSASSV---------NGYTLNDFFN---QINTGDY--------AILT PSDDNAGVIATETASSNIYNNSSSNESI-MDMANQLLD---ELAHGNF--------SHLT PSDDNGDVITTEIASSN---NSTSNESFAMDKANQLLE---QLGHGNF--------TLLT PSDNIADVITAEIASSDNYHNASSNESL-MDVANQLLD---QLGHGNF--------VQLT PSDDNAGVITTETASSNNHNNASSNETF-MDMANQLLN---QLANGNF--------TQLT ------------------------------------------------------------ VLGEAKLHVERVGHDAGQDYRGNTPVDI----MDAFIQ---QVREGNV--------TVLN ----------------------------MATTLEQLFQ---QLHQNNV--------SVLS WIKDAREGNSSSEIDDNRTYVGNGGPMS--MSVVQFINEINQTYSISDNRKIDQLTRLLS ----------------------------NDDALSQFFR---ELASSNV--------AILS -----------------------------MEVLDTYLNEIFQCSNSPVNEQLIRLSNLLN WMKDAREGNSFSEIDDNQTYVGNGGPMS-------------------------------- PIMQNQQLANQHFASQQQHFQREAPVSYGLMSISQFIHEIDTSYTLNNDDRIRTLTNLFS DLRNQGMDNSSLSADDHPTYVASVNRVV--MSLMKFINEINQTYSITDNNKIQELTRLLS PVEARSSLEVKHNSTSSSDIMS-------MDVVHGFLLQVQNATKAPPAQQPQMLLSCLR EQRTTSSFVPSSYHEPETYTRV-------MDLVNQYLAEIAAVARIPNQQQISKLTTLLN PSTRPVSGQDYRGVQDNQYAAGYPSPQI-MDPLNDFLFEVERSLKGSPESVSVHLARLLT LASTDNEFKHVIINDTDTANDVVV----MSYNLSSFFN---DLSNGLF--------INLS ----------------------------MVQQLLTRLAGLTNDESIDPQSKLAELFTPLL INIEKNGVRIAALQNDLQGQDDKMIDRLVDGSKIIPTRWTRLNIMVVSFLKFCRDVDPWS INIERNGQLILELQQFLRSNDSIDLETLINSHSLYENRWTRFNNLVSSFLGYCKELNPYS ------------------------------------------------------------ LNLQSNGSQVASLQQELQ-NDNNQLDELIEQKVTTKKRWARFNIMILSFLKYCRDLDPWS LNLSQNGREIAILQKQLTGFDDKQLETFVEQHPAMPND-TRFKIMCTSFLNYARDVDPWS LNLSQNGPEVAILQQQLTGSDDGHLEALVEQHAAMPND-TRFKMMCTSYLKYARDVDPWS LNLSQNGHEVALLQQQLTGSDDKRLETLVEQHPAMPND-TRFNMMCVSYLKYARDVDPWS LNLSQNGKEIAILQQQLSGFDDKHLETLVEQHPAMPND-TRFKIMCTSYLNYARDVDPWS ------------------------------------------------------------ INLDKNGLLIAALQKELQNRDDSTLDRYVEGAQLHDGRWTRFNVLVCSFLRYCRDVNPWS VDLGKNGRFVASLQQHLQANTPGQLETLVENQAFHGGSWSRFNILVVSFLKYCKDVNPWS INPQQN-KYIAIIYNS------KSIPSTITTL--YDDDWSAFSLILTSFIKLCHLMDPWS INMEENGTLIARLQGVLQGFSTKDLEALVEKQKLQGGNWTRFNIMVTSFLKFCRDVDPWS VNPAIN-PYIVRINNLPF-LQDKYLNDLIDGKHFYKDEWLAFNEVVISFIRLSNQLNPWS ------------------------------------------------------------ LNPLEN-KYIVSIYNESF---EQSKSHSFTTR--YGEEWPAFDSVVSSFINICTLMDPWS INPQEN-KYISIIYNA------KSIPSSITTL--YDEDWSAFNLIITSFVKLCHEMDPWS LHPSLN-PFVVQLNNVGN-LEEEQIAQAVEMRHFFNDDWAAMNSVIVSFVHLANQLEPWS VNPQEN-PYIVQLNLINFQLEDAQLSKAVDSHRLFNDEWLAFNEVVLSFIKLSNQLNPWS PS-VTN-KQIINLNNLPQLASDRY-NQAVDSRHFYNNEWLAFNEVVCSFVRLGNQLNPWS LDLAVNGRIVSQLQSELQGNNDKSLESLVESQSFQKSEWTRFNIMVVSFLRYCRDVNPWS LNPNTA-ALQVSIQN----WTDEQVSKSVEQAHLFDGGWGGFEQFVESYIRLVRDFDSLS LWTSSDLIFEHYSNLNNALLDDSYPVDALTELFLSETEYVTKLAIKLDANNLDLGTKQSL LWESSFSVFQYYQDLNTCLTNETTMYPSLVPLFTATTELVIPMAIRLDANHKIIGTRQHQ ------------------------------------------------------------ LSSSCDLIMDFYTNLTNCLLDESYNLEPLLPLFLEQTELIIPMGRKLDESYMELGTRENQ AWSSSDLIFEFYQCLINCLINDNAPHIMLIPVATRETEFIINLAGKLDSFHLQLHTRSHQ LWSSSDLIFEFYQCLINCLINDSAPHIALIPVATRETEFVIVLADKLDAFHLQLHTRDHQ VWSSSDLIFEFYQCLINCLVNDNAPHIKLITVSTRETELVIGIADRLDSFHLQLHTSGHQ VWSSSDLIFEFYQCLINCLINDNAPHIALIPVATRETELIIGLAEKLDSFHLQLHTRSHQ -------------------------------------------LKRLDSNYLIIGTKRHQ LWESSDLLFTCYQDLGNCLLQDSYPIEGLVGLFKEETEWIVPRAVRLDSNRKLVGTKKHL LWESSDLVFNYYQDLSNCLLNDSYPLENLVGLFKDTSDYVIPLASRLDQHYQTMGTKQYQ LLKSFDLYTTFLNDLSVGFNNNSYGWL-LSNIIKDTISQMVPWARKLDLIMYFKEQGGKF LWRSSDLIFIYYQDLTNCLLNDNFPVDKLVTLFQETTEYVVPLAKQLDIQYNVLGTRKYQ SLESFDLYTNYINDLSVAFNNANRGYL-ITYLVKDTIRFVIPIATKLDYQLYYKENCMKP ------------------------------------------------------------ VLSSFDLYTTFLNDLSVAFNNNTYGWL-LSHSIKATIAMVLPWALQLDRQMFGKEKGGKY ILKSFDLYAAYLNDLSIGFNNNNYGWL-LSNIIQSTTSIIVPWAKNLDLMMYFKEQGGKF LLESFDLYSRYLNDLSIAFTNKARGHL-LTPLLEDSIEFIIPLASRLDHQLLLKEKHRKP SLESFDLYGTFINDLSVAFNNNKNGYL-LSSLVRDSISVILPLARSLDAQLYAKEHCSLP ALDSFDLYSGFINDLSVAFNNNVRGHL-LTNLVRETISIVVPMATRLDRQMYYKENCANP LSESYDLIFQFYSDLNNCLLNDNYPIDPLVPIYQAATEYIIPVASKLDDHYMVLHTRKHQ ESNSFDLVVSTFTDLQVAFSS-ARGVC-LTHTVALWARKVVGGAFQYDNEHNLAQTTATP FLSYISSIISKLFNSIKPPRDGANST---IPNKQLILLNIINKLNNIYFRINSPQLCSNI FLTHIASIISKLFNSIKARVDDDKVEFDHLSGKQKVLLYISNKLNMIYFKINSPSSCANI ------------------------------------------------------------ FLSYLSSVISKLFNSIKPSHSDDVNQNKKISGKQKILLFLVNKLNNLYFRINSPQLCSNI FLSHISSILSRLFNSIKPPRGNASST--NIPGKQRILLYLVNKLNNIYFRIESPQLCSNI FLSHISSILSRLFNSTKPPRGNASSE--DIPGKQQILLYLVNKLNNIYFRIESPQLCSNI FLSHISSILSRLFNSIKPPRSNASSK--NIPGKQRILLYLVNKLNNIYFRIESPQLCSNI FLSHISSILSRLFNSIKPPRGGASST--SILGKQRILLYLVNKLNNIYFRIESPQLCSNI XXSFXXXVXSRXXNXIKKLENGD-----XIPXKXTILMXIVNKIXXIYFXIDSPQLCSNI FVQHVASVISKVFNSIKGRVDEAASAYAALPAKQQILLYVANQLNNIYFRIDSPSSCANI FLTHVSSIISKLFNSTKARFDEPAKPFGELPGKQKILLYIVNRLNNIYFKIDSASSCSNI RLNYMASIILKMFNNIRINDSNV--------YKKSIILYLGNTLCYIYFKLDNPLLCRNI FLSHVASVITKLFNSIKPRFEEPAVSFNELLRKQQILLYTANKLNNIYMRIESPASCANI RLAYLASILLKIFNNIRSQLSGDVSDTTKVSSKSSIILYIGIRLCQTYFKLSNPLLCRNI ------------------------------------------------------------ RLNYLAAVLLKIFNNIRVNDSNK--------YKKSIMLYLGNNLCYIYWKLDNPLLCRNI RLNYMASLILKIFNNIRINDSNL--------FKNSIILYLGNLLCFIYFKLDNPLLCQNV RLTYVASVLLRIFNSIRSSLGAGDHIEM---MKKSIMLYIGARLCLVYFRLGNPLLCRNV RLTFLASILLKMFNNIRSQINDV------NENKRTIFLFISIKLCSVYFQIGNPLLCRNI RLTYLASVLLRIFNNIRSQLSADPHDNS---PKRQIILSVGVTLCQVYFKLGNPLLCRNI FLSHCSSIISKLFNSIKPSRSIDMSEPSQLPGKQKILLYLVNKLNNIYFKIGSPQLCSNI TSEYIATPLLRLFNTTRTERSDM------EFTRKSIILHLACLLCRVYFHIRQPTLCANV FKNFKPKSMFESFKRYPIHEQIEFRYLLGRYYVINFRMTNAFVQLDTAFRMLCQYCPHTA FKNLKPKSNIYSFNQYPLTERIQYRYYLGRYYLLNHRMVNAFHQLNQCYELLATLPDSIA ------------------------------------------------------------ FKNFPLKSSTKQFSQFNFKEQLEYRFLLGKYYMINGRVSDAWTQFNTSFAQLILINRQSD FKNFQPKSMLAHFNEYQLDQQIEYRYLLGRYYLLNSQVHNAFVQFNEAFQSLLNLPLTNQ FKNFQPKSMFAHFSEYRIDQQIEYRYLLGRYYLLNSQVQNAFVQFNEAFQSLLSLPLTNR FKNFQPKSMLTHFNEYQIDQQIEYRYLLGRYYLLNSQVHNAFVQFNEAFQSLLSLPLTNQ FKNFQPKSMLAHFNEYQLDQQIEYRYLLGRYYLLNSQVHNAFVQFNEAFQSLLSLPLTNQ XKNFRPKSM-APFREYPIKEQIEYRYLSGRXYLXNNMVTNAFVQLNSAYRQLALVSDCVH FKNIQPKSMIEHFQQYPIEEQVEYRYLLGRYYLSSYRISDAFAQLLRAFQDLCALAQAPV FKNTKHKSMVERFSEYPAREQVEYRYLLGRYYLLNHRISDSFHQLNSAFQMLAGQSPQL- FSNMQNTSL--KFNEFNLDQQLKYRYYLARYYLIKYQLIESFNHLQWCLVN----TSS-- FKNVKPKSAIQNFSQFPVNEQVEYRYLLGRYYLLNHRVSNAFHQLNSAFGLLAVTASRNN FSNMNNANL--AMGKYDMNEQIQYRFYLGRFYFLKNQLVDAYTHLLWCLQR----CPVVA ------------------------------------------------------------ FSNMSNTSL--RITDFLHNDQLKYRFYLARYYLTKYELLESFAHLEWCLVH----TSS-- FSNMQNTSL--KLKDYPITQQLKYKYYLAKFYLIKNHLLESFENLKWCLLN----TSS-- FSNMNNANL--QFHSYPMNQQLQYRYYLAKFYMVKYQFVDAFQHFSWCLQH----CPPNH FSNMNNANL--TFSSFSKNEQVQYRYYLAKFYLIKQQIIDSYDHFLWCMLN----CPSTS FSNMNNAGL--RFSRYSVAEQVQYRFYLSRFYLIKDQLPDAYVHLMWCYET----CAAAT FKNFKPKSMVTIFSEFPVKEQVEYRYLLGRYYILNNKIVDAFIQLNNAFLMLSSVVLNIK FSNMSTAGI--RLSAYPKSQQVEYRFYLGKFYWLKSQLKNAYLHLYWSWDK----CYTQ- TRQRNLKRILKYLIPVGITIGKKPHFQAVRG-IDLDLAKSYIELSRNVNSGNFKQVNIWL K-QNNRRRLLKFLVPCGIIISKLPDFNKLSQ-WDPILAQKYTALVIAVKNGNLNRVNFWL ------------------------------------------------------------ QWSRNVQRVLRFLVPLGIVAGKCPQFDGRYAEYLQRLKINYPELIQAVTTGNMFAVHGWL AITRNGTRILNYMIPTGLILGKMVKWGPLRPFLSQETIDNWSVLYKHVRYGNIQGVSLWL ATIRNGSRILNYMIPTGLVLGKMVRWEPLRPFVAQETIDTWNTLYRYVRFGNVQGVNLWL AIIRNGSRILNYMIPTGLILGKMVKWEPLRPFLTQEIIDNWSALYNYVRSGNIQGVSLWL AIIRNGTRILNYMIPTGLILGKMVKWEPLRPFLSQEIIGNWNALYRYVRFGNIQGVSLWL PDRRNLVRILIYSVPTGLMIGKLPRLNLIRS-LNATIADRYSELARHVRGGSIKGLNGWL PVQRNMVRVLRYLVPAGIILGRPPPFALLES-LAPALGRSYSELIHALKTGNLQAMHQWL --QRNMYRVLKYLLPTGILFGKVPATAMVAR-VSTELAQMYSGLIRVVKEGNIGGFNQWL --LKNQKLTLELLLPVSLILGKIPNFNYLSQGFNFPFVQMYQTLSKSIRAGDYSKFKQVI EPKRNLQRILKYLLPAGILFGKLPSASFSAQ-VSPQLSEQYIKLVNAIQAGCFLRFHHWL D-SSNITRILQYLIPISIAIGKRPNFNFLQQSTTPSFFAIYLDLSQAVSLGNYAHFYTTI ------------------------------------------------------------ --PKNKSMIIELLLPISLVLGKKPNFATFHRGYAVQILSIYEQLFRATAKGDYVSFKLVL --LKNQRLILELLIPISLIIGIKPNFNYLMSGLNFEFFGLYQQIAQVVKTGDYQSFKKII LQNLNVTKILRDYLPVSIVLGKRPRIENFKSAQCPAFLDLYGQIVETVNRGSLFDFHQLI --TSNINRILNYLLPLSLIIGKVPNFQYISQTPPPPFFNIYMRLSAAIKLGNFLLFNDVV SVNSHLTVILKYLLVVGMMIGKNPSFNTISQGNSPPFLTIYNEISLQIKAGNYTQLVAVI IEKRNINRILKYLVPVGLMMNKLPKFWIVSK-IDVNLANKYKELSDCVRTGNIKGLNGWL --STNKRLILKHLVAVSLLLGIIPTRELLQQ---FNLDNIYGEMVVALKHGNHTRFYAAL ASNEDELKSQNLLLPLLQKLPILVFRNLFRKVVIEYVLSAQNNKISYDLLMRALQVSIG- YENESWLKSSKLLIVLLEKLPIITFRSLLRSIFLYYCIPRNSNKLPYSVIRPILAKSIGL ------------------------------------------------------------ QRNESLLRRDHLLLLLLEKLPIVVFRFLIKRLLTNVIDVEQGNRIPYSLVLRGLQYSIEA RQNERHLCARQLLIVLLEKLPMVTYRNLIKTVIKSWTTEWGQNKLPYSLIERVLQLSIGP RHNERHLCARQLLIVLLEKLPMITYRNLIKTVITIWTTEWGQNKLPYPLIERALQLSIGQ RQNERHLCARQLLIILLEKLPMVTYRNLLKTVIKIWTTEWGQNKLPYSLIERALQLSIAQ RQNERHLCARQLLIVLLEKLPMVTYRNLVKTVIKFWTTQWGQNKLPYSLIERALQLSIGP QTHESDYAS--------------------------------------------------- RSHEDELRRRRLLLLMLEKLPLLAYRNLLRRVFQIVALPAYSNRIPYAAVETALRLSIGS FTNEQLLRRDKLLLVLLEKLPILIYRNLIRRVIATVVIPQGSNKIPYQLIEHAVRFSTGP DSNYHYLKDKNLLLLM-NKAEILILRNLIKKV---WIVLDKPSTMNYLNI---------- AQNETILREQKLFILLLEKVPLLIYRNLIRRVILEICLPRRQNKISYALLERALQISLGS TNPYSFLKDADLLVLLSSKCVLLVVRNLIKRL---WMLAGKVPKLDYDSIKLGLSASVSL ------------------------------------------------------------ NNHRDYLKDKNLLLLL-NGAEILIFRNYLKRI---WKFMNCPSSLDTKII---------- NENSQYLKDKNLLLLM-NKLDILVYRNLVKKV---WLLLNKPASLDYTRI---------- NHPYEFLKSHYLLLFISIKTCVVILRNLVRKV---WSAQGKHPRLDYDAIKVALELSISI VENYQYLQDANVLLLLINKSKVIILRNLIKLA---WIRLGRPSSLDYEVVRISMK----- SQPYEFLHKNGLLLLVVNKAKLITVRNLLKRI---WLLSGKPTRLNYSSVRAGLQVS--I KLYEAELRKDHLLLILIEKLPMLTYRYLIRKVVLEYTMPLSGFKVPVFSIRIGIK----- ENARDWFIDRDLYVLLKSRAFTLLDRGSLKVIYE-WSVAQGNPAIDYGTVARGLDFATQN ---SDQLALPPMFKVIHRPEDVENILVTLINLGFLRGNCFPALRLCVVKKTTDINDIFPE Y--PP--EMPSIYKDNYTAESLENILVTLSIQQLWKGNVFPSLQVCVTMKTNDISVIFPN ------------------------------------------------------------ SDADPV----TIYNGIHHPDTVENVLVTLINLGFLRANCFPQMKLCVFQKNTPVKEVMPR TFEDPGAQEITIYNGIHSPKNVENVLVTLINLGLLRANCFPQLQLCVVKKTTMIQEIVPP AYEDPTVREITIYNGIHSSKNVENVLVTLTNLGFLRANCFPQLQLCVVKKTTMIQEIVPP TFGDPNVQEITIYNGIHSPKNVENVLVTLINLGFLRANCFPQLQLCVVKKTTLIQEIVPP TCEDSTTQEITIYNCIHSPRNVENVLVTLINLGFLRANCFPQLQLCVVKKTTMIQEIVPP ------------------------------------------------------------ P--EP--TAPPIYRLVHTPDNAENVLVTLINYSFLRGNCFPLNRMCVTMKTTNLLDVFPA LHAGMS----PIYNTIHSSGNVENILVTLINLSLFRGNCFPLNRMCVTMKTNNVNDIFPC ----------PIEGHYNDELYLENVFVTLIDSNLIKGK-LTSSKTVVLSKT----DTFPD ANEMQQTK--LIYTAINVPGNIPNVLESLINLTLLKANCFPLSAQCVFPKTTNISDVFPP PDGTPLTSLPTFVSHAPDDLTIENILISLIDQNLLKGKLFPRLRVVSLSKV----NVFPP ------------------------------------------------------------ ----------PITGK--DIQFVENLLVTLIDSNLVKGK-LTGKQTIVLSKN----DPFPA ----------PIYDHENDELYLENLLVTLIDSNLIKGK-LTMNKTVVLSKN----DPFPK NAVPAQTSSAQKPSAPVDDLIVENCLITLIDQNLLKGKLFPRLRVVSLSKT----VAFPS ----------FLVQELDDDSIIENLFISIIDQNLLKGKIFPRVRKVALSKT----ATFPK NVNAPL----DMYKLISDDTTIENVLVTLIDQNMLKGKIASVARAVSLSKS----ETFPT ----------IIYR---------------------------------------------- GGYAQQVLAPQMMGGGSAKLTSEAILVALIDQGFIKGKLQATGQRLIHAKA----NVFPP MTERIVKMFPLN-NEDNWFDIERAATHFLRLHKSGISALDYGITSPVLFSGDIDGEVTIW INEKIVSRFSLN-QEDSWLDK---MPFTLRYHTCGVTSLNDEQDVPTLISGDEKGSILVW ---------------------LTLSDFTLRNHKKGITALALVSKVPVLLSGDSDGLFVIW VDQRISLQFPLN-QDDSWLSSHSLPKYTLRNHTDPISALARDTVVPYLISADASGKIVIW VNERITKMFPAH-SHVLW---LTLSDFTLRYHKRGITALPSVSNVPVLLSGDNYGYFVMW VSERIIKMFPAQ-SRVLW---LALSDFTLRNHKKGITALPLASKAPVLISGDSQGLLVMW VNERITKMFPAQ-SRILW------------------------------------------ VNERITKMFPAH-SHVLW----------------------------MCVSGDE------- ------------------------------------------------------------ ITPKIASKFPQN-HDDAWLDS---MRFTLRAHVSTVTDLVSHRQTPHLLSADSKGCLYLW VNEKIVAKFPLN-NDDSWLDENIAHGSTLRAHKSAITCFISISVIPLLLSGDSNGDLYLW VFNIYKLKYGNNGNSNQWV--MLSTKFTLRSHKSSVTYIQDPRTPFNLFTADSSGLIINW INEKLVALFPLN-TDDSWLDEKNNVAYTLRKHIAEVTSLVPREPYPILISGDSQGHIYLW VDHINFLRFGNGNASDRWLRNKPIELCTLRGHLNDITCTYYIGGKVSLVSADSNGWIIWW ------------------------------------------------------------ VFDMYTRRYGAHKPNNSWM--APQQQFSLRYHKASISYI-LPISSRYIYSADQSGLVIKW VFNIYQVRFAKR-SLNQWM---MSQQFTLRSHNSSITFIPSPTSSLHLYTADSTGLIIEW VDSINFVKFGNGSYADKWMN--MEKMFSLRAHAAPVSGF--CPWENQLVSADRSGTLIVW VDEANIARFWNNKNSDRWMQKTPQQIFSLRSHENSISNIVFLWNKHCLISSDTKGWIIIW ISEINFRRFGNGNKEDQWMLTEPRQKGALRGHKNPITCTDHKRNCNTLVTSDNEGWVAWW ---------------------VTLSEYTLRFHKDAVTDVLTNFKVPVLISGDGSGKLVIW VCVVLGSRQSSLKDDEHWMESAPVPVALLRGHTHPVTSL--RFYNAFLVSGDESGWVFWW NLITRRPIFTSKICNEQVVDIQFLEGKYLSLLCKDHKLRLYEL-----LKLGAIKQIFEV NLLSRKPYYKYTCRGQ-IVSFQQL--NLIIATSKDHTLRILKFPSTLTTKEGFPELIYEI DLVTKRPVTCTQIEGHPIIAFQWVDSTVLSVLCKDSMLRMFNLEVSALLSTDLVTQIYEM DLITRRPVHTFASGVIKVISLQLLSNNLLSVLSKDHKLSIFHNKGDEIKSWDLV---FHV DLVTKRPITHIEIEGNSIIAFWWVETTVLYILSKDSMLRIFELDSSTQLSIDLVTKIYEM DLVTKRPITSMQMEGDPIVAFQWVESSVLSVLCKDSMLRMFKVKKPAARSTDLVIQIYEM ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NLISRRPIASIDLKTH-IIAIEVVGQGLYAALARDNKLRFISLQEESRLTRINDEIVYEI NLLTRRPILHYQGDGGNIVSLDHI--DIYVVHSKDHNVRFFRTPGNDTIIERCDVQIYEI DLAIRRPKKSWQAHTDTILTISTIHNH-LLTHSRDNTIKIWDESY---------ICILEI NLITRRIFAEFELNSKAVISVDFIDGY-LTVLSKDHTLRFLRIEEDTS----LIKSVYEI DINTRRPNCVWKGHDSNIVTLRQICNGLLLTHSKDSDIKIWDVENFKSGSREMPNELLEI ------------------------------------------------------------ DLQIRRPKLQWQAHKDSILTILQW--HYIVTHSRDSTIKVWLED----------ILQFEM DLITRRPVITWQAHNDTILSMSTIHNH-LLTHSRDNTIKIWNNT----------DCIMEI NLSTRRPAARFRAHEGQVLSMQ--PTRGLLTHGRDSAVRIWPPGAAENSKGGDPHPIFEM NINAKRPIRKWQAHDETILTLTLISTNTLLTHGRDASLKIWDISVEHAESSP--PELFFL DISTKRPLGVWRAHSNSILSVVQIDHNLLLTHGKDSCVRIWAITQYEGFSKTFPWPEYVI NVITRRVQFVYEIPKSPILAIEYL-GDLVAVLSKDHKLRILQLQLDESKTLVKTNIVFEV SLVTRRPLAIWKAHHEAILSLVWMDETHLLTQGRDDKLYVWRLELDAQGKSGLSWLTYSL PVNTLNFANYVLTYFELVTCHTQDAHFIDIYEFETPNSLKRFSKAIDFLPMLRDLPKMDG PVNTLNFANTAVEQYRLWCCNTQDSETIDIYEFDLRKSLKRIHRALSLYEVISGTMKFDK PVNTLNFANFVMDSYRLICCHTNDSEAIDIFQIMQDFKLQRPFNNINFPKFLKKVPKDSK PVNTLNFANCIVYHLGLVCCNTQDSEAIDIYTFILNHSLKRQFNALNFFGSIKEKLNFEK PINTLNFANFIIEAYRLVCCHTDDSETIDIYQIIEDFKLKRPFNNINFPRFLKQISKDSK PINTLNFANFIMDAYRLVCCHTSDSEAIDIYQIIEDFKLQRPFSDINFPKFLKELPKDSK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PVNCLNFANFALQDYRLWCCNTMDAESIDVYEFQLGQSFKRTFNAINLFDSVAGKFRFDK PVNSLNFANVSVTHYQLSCTNTMNSEGIDIYNFDINHSLKRIFADINFYETVKAVFRFEK PCNALNFSNICIIYDLLITPASINSNNLDVYKIDKDWQITRLISDFDVYKLVNKGTSRND PVNTLNFANVAISTYRLWCCNTTDSECIDVYSFDIKQSFKREFNSINLHEAVTENNPLEK PVNALNYCNVDYSNHHLITPATTDSNNFDLYLIFKPLNLKRVAANIDPWKLYKKILKRDK ------------------------------------------------------------ PVNALNYTNIVLYRNYLITPATLDSNNVDVYKLKQHIEVSRVIANISIFELVNKMQGRQD PCNSLNFSNVVVVHEILITPASINSNNLDVYKITSDWQLTRLISDINVYQLVEKIGSRND PVNALNFCNVAYIDALLATPASVDSDCFDVYRLSPDFSLARAVENQAPKQEQRGAPPGRG PINTLNFCNVQYFNDFLITPASVDSNNFDIYKITNPYEFKRVLANFSPFDLYSKEQGRND PVNTLNFCNVCYLNGKLITPATQDSNNFDIYSIFPALSLRRIVANADPLALHKKNSKRDG PVNTLNFANFSLEKYRLVCCNTQNAESIDIYAFKLNNSLKRLNKGINFYKTVIDISKFDK TVNSLNFCQVAWVNGLLAKPDLDSSDKVELLEWTD-GAFRVVWNDIYP------RLNGIK LGIIMKFYKVNEVVYCGFESGYVIAFLDNVIEIVLVDRAHYPDPVLDMAPKKNGIICSST LGTTMKFIIYEGIIYLGFESGFVIGL---GLHIVYISSANYPEPVLDLTVDLGKVISSST FGIIMKLVRINDIIFLGFENGYIIGFQKGVAYLIHISNDHYPNPILNMCVSRDELYSCST LGIVMKFTRDSKVIFIGTESGLVLGFQRHVIELVYVSDLHCPNPILDLEIKDNILLSCST FGIIMRFAKLNDVIFLGYENGFVVGFQRDIAELVHVSNDHYPNPILDMCVSGDELYSCST FGIIMRFARLNDVIFLGFENGFIIGFRKHVVELVHVSNDHYPNPILNMCVNGNELYSCST ------------------------------------------------------------ ------------------------------------------------------LYSCST -------------------------------EIVYVSHVHYPNPILDLYPDN--ILSSST MGIVMRFIVAGDTVFCGYESGVVVGLRDKSLQICYASFAHYPEPVLSLAHTERRVFSSST LGIVMKFLECNATTFFGFESGFVIGVLKDCLEIVYISSLHYPNPVLDLSYDAHTLMSSST FGIIMQMKIIDYIIYVGFESGDIVGLQSAKFILRYHNSTHAPNPVICLSNLDSVLVSGST LGIIMSFIECDGSVFLGYECGFVVGL---QLVIAYASAVHYPEPVLSLCYKERTVLSSST FGIMMKVLFVDDLFYIGYESGHLIGYKDPHIKMIYMNDSCSPYPIISLVYKENKIICGSA ------------------------------------------------------------ FGIIMKMLVIDMTIYIGFESGDIVGLREPRLKLEYQNTLLVPNPVISLANLNGLLVSGST YGIIMKIHLVDNIIYVGFESGDIVGLQSPKLIVKYHNSIHVPNPIISMSTFQDILVSGST EGIIMRLAWAPDLLYVGYESGALASFSPEGCRMLWLARAHSPHPVLSLALEGARVYSGSA FGIIMKLVYVSNQLFLGFESGQIIGLKEPRVNLIYSDSSHIPNPITSLVHLKDNLISGST FGIMMKVVFVPTLFYIGYESGHIIGFKEPTLEIIYISAFHCPHPITALFFK---LYAGSA LGIVMKFLRVNDLVYCGFESGIIICFYENMLEIVYISTVHYPNPILDLSIKDEEVLSSST TGIVMDLNIMNKKLIVGYEGGAVAVFSDRTPVLNYYVVSHV-QPVLSVRATKKEFVSSSA TNKLVLTSVDMSTNLKIDGSAVKDMMCKNIGFVLSLGDYIITGNWSGKTYIGRIEAKSRS NSSLGLHTPNVVVDDSTIHSEMVNIPINKVSHIQQVDNLLIAASWSGRTVVFDINLKERG NSFITKHKFSCSSTLRVTEPSKVHLPLKNISHIVITDDYLVVSNWSGKTIVINVHVKTKN LKKIGSFCLKREKNLKLSDNSFYEIPFSNVSHVQSTKDYILAADWKGETFVFSNQEKSRS DDFITKYKIPCPSSLRVSEPSKVHLPLKNIGHIKVKDDYLVVSSWSGMTIVYNMRVKSKN DDFITKHKFSCSNTLTVSEPLKIHLPLRNISHIKVTESTLLVSSWSGKTIVLNVHMKTKN ------------------------------------------------------------ DDFITKHKISCPSTLRVSEPARIYLPLKNISHIKITDDYLLVSSWSGITIVLDMRMKSKN DNKIGIHDSNLKKELHSLSANFKQVPISEVAHIKKIDNLLLLSSWFGETVVTDEQAKFSK TDQVCVHNIPQVVANAGTREEVINAPLKKIGHLAVLNDILLLTSWHGYVLGLQDQYRKER DDKIGIHHVPIVKRSMEISTGGIETSVKEVGYVSCVGDIMALGTWSGKTVIFKSLSRSKS TNKVIIHSDP---------IEIMKMDHSGIQAINFKNDRLIFGYWNGYIQYGDISINQSL DGSIGIHKIPCEDFCSQG--DKKQLATIQIGHLECIDTALVAANWHGETLIFEDYSKQRS GKQLTFHKIPFSQFNDISDCKRYNLRHSGIQSVSINNSLLVVGFWDGLIKGYDLDYCKRL ------------------------------------------------------------ GTKVVIHSDP---------TRTVKFHLSGIHSIQTYQDRLVIGFWDGAIEYKGEIIQRPL TNKIVIHKHP---------VEIIKVTHSGVQSINYKNENLIIGFWNGEIRYDENVIKRDV AKTLLVHEPP-----HEEAVAKHNLGHYGVQCFEILPHLYLAGFWDGSVAGFSRDWQQLF NKQVIVHHYQHSIDSSDAHLDVKKVAHSGIQSIDEKTDTIFIGHWNGVIEGVDYKLKRDL GKTLSIHTKQ-SSIAEEPEIESYNLKIAGVQDIAVLPELAIVAFWNGVVKGYEKQFKPAW DSKIGIHKAQIVRKTLGADTSFVEVPVTEIGSIKSLKCGMVLGGWNGKAIVVDNNGRTKS DSLIVKHPIKEEEKPESKPLDAVNVRHSGLSSLDSDGDLIMTAGWDGKVRLFTYD----- LIEVGNIQ----QDKSIQKSSKHTKIGAMTGFEVKDKEPDKLTPGKLRRLNAFVQSKWYF QVLIDDNPYGNASLPENSTKVKISAMTCIPKFNTVNPSCTS--EGTRRRWIRFYKETWCL NLVIGSLTNGNNSNTESSLKSNNYKVGSMICLKSSDVKSDGLKLGELRRIKTLAKFNWCI SIPKGNLQNVNSSSGPKKANKSKVRSIIALDSTTNSLDETLMTPGQQRRLLKFAETSWCI NLVMGDLTNGSGSNTESSSKSHNYKVGAMTCLESFDVQSDGLRLGQLRRIKALAKCNWCL NLIIGDLTNGNNSNAESSLKSNNYKVGAMTGLKSFHLQSGGLKLGELRRFKGLADSNWCI ------------------------------------------------------------ NLVIGDLTNGSGSNTESSSKSHNYKVGAMTGLESFAVQSNGLKLGELRRIKALAECSWCL SKSENPQGNSQSNNTSSKSKNPNCKVSSLEGLSSSNSKDSNTNVGQRRRIERFLQNSWCI NLLVDDSTDGQAETKKEKPWINPGPIAGIAHSTDSQLVLEKLPIGGHRRLKNFLEHKWYI NVLVGSYQNPDKE-------KKRAKIGAMCLLPKNKTPGGGKSKGEERRAKKFFSEDWCI PKL------GNTEQEKSKLTKKLTFMTILNESNQETLQSPTSKYSVLLKSKRNLVSPLLL NVLVGTFSEQKSP----KTWIKPCSIACLSKQVSTSLAG--IQFGDKRRIDYCSKFNWCF PRIVLESNSGQQQPREKQNSIKLCTVKLVIPNETDVVKSNDKSLIKHKR--DITTTNLLI ------------------------------------------------------------ PQIINSNGDDENEEENLKSNVKLTSMTLSSFGNSSGSDTAKVQHVRKPKYSEMVKSDALF PMI-----QNNDNDDRSKSIKKLTFMTLLVPQKVESTTTGKNKYSQLIRGKKILTTDTLL SL---ERPHEQIEAPESPSRKSLCLFVWSAPAAPEQSRRDR---LRSRRAAG----RLLF PHLTSTNSSGGDTNTIAKEAVKLTSLALLIERENTQVTTTKKDLVKARSAYIGNDNRLLF KMSIGTLESNNGQKEAQELPSKVKANTLCILKSSAITHSSYRDLVRARQVSP----RLLT NILIRSIQNDSDSIIKMKKNYKIKAVDGIDGVGTDISQLSNISRGDQRRLDKFLSSSWCI ------------DISKVSVFHEREGVGCVAFSTPTTSDTAN------PRLAKALTTRWIA IGYTDGTIGLYRA----------------------------------MVLPIIIGVGVTL IGYADGSIKATEV----------------------------------MVLPIIVGIGITT IGYDDGTIKLNRL----------------------------------------------- IGYDDGCISLHDL----------------------------------MVLPLILGVGVTF IGYEDGTIKLNKI----------------------------------MVLPIIIGLGVTM IGYDDGTIKLNKV----------------------------------------------- -----------------------------------------------MVLPIIIGLGVTM IGYDDGTIKLNKI----------------------------------MVLPIIIGLGVTM IGYDDGNIAFHRL---------------------------------QMVLPLIVGICVAG TGYNDGTITVSQI----------------------------------MVLPVIAAASITA IGYEDGSIALHSI----------------------------------MVLPIIVGIGVTI AGYEDGSILAYNI----------------------------------MVLPIIVGLGATI TGYEDGSIIMQNF----------------------------------MVLPIILGLGVTF SSYYDGTITIFKV----------------------------------MVLPIVIGLGATI -----------------------------------------------MVLPIIIGLGATI AGYEDGTIMGYAL----------------------------------MVLPIIVGVGATV VGYEDGSIVAYKV----------------------------------MVLPIVVGLGATI VGHADGLIVAYAI----------------------------------MVLPIVIGVGITA AGYEDGAVVAYRL----------------------------------MVLPIIVGIGATV VGYADGVTIMYEI----------------------------------MVVPILVGIGVTV VGFDDGCITLDSI----------------------------------MVVPIIIGLGVTA VGGKDGKIELYTI----------------------------------MVLPIVIGVGVTL VAWTTQSALRAWQIYRTLTPGMIAAMNGIKLHSRLNPGLKMQLNKWEGGFYHPMSESEAL IAVVARSGLRAWDKYCRLTPLMIAQFNNIHIYRRLSPELLTKLDRYPGGFYDKMSETEAL ------------------------------------------------------------ VAVTIRSGLRAWIVYKSLTPIMIARMNGIRIQSKLSNELKTKLDQFQGGFYPTMTESEAI VALSVKSGLNAWTVYKTLSPLTIAKLNNIRIKSLIDEELKNRLNQYQGGFAPRMTEPEAL ------------------------------------------------------------ VALSVKSGLSAWTVYKTLSPLTIAKLNNIRIKSLIDEQLKNRLNQYQGGFAPRMTEPEAL VALSVRSGLNAWTVYKTLSPLTIAKLNNIRIKSLIDEELKNRLNQYQGGFASRMTEPEAL ISLTARSGIRAWEIYKVLSPMTIARMNKVRISSRLDPESQRKSNEYPGGFNPRMTESEAF IAVALRAGVRAWQTYKQLTPLMIAQLNGLRIRTQLPRSVIAQLEQYPGGFYKRMNEVEAM SAITIRSGLRAWDAYKRLTPLMIAQLNRVRVYRGLNQELQSRLNQYPGGFYSRMTETEAL VALTAKATITAYKQYLHLTPAMIATLNNIKLKSPRYAHYKYLRSKYPNPFLDPMTEQEAL AAVTVRSGLRAWDVYRRLTPLMIARLNGIRIRYDLNPGLKARLNQYGGGFSSKMTDSEAL AALTAKSTISAYRKYLLLTPHMIASLNNIRLKLPHDSIHRFLRQKYPRGFNDKMTEQEAL VALTTKATITAYKQYLHLTPQMIATLNNIKLKSPRYAHYKYLRLKYPNPFLDPMTEQEAL LALTARATIASYKQFLTLTPQMIANLNGIRIKSPRYQHYKFLRLKYPNSFLNPMTEQEAL IALTTKATISAYRQFLHLTPTMIATLNNIKLKSPRYEHYRYLRNKYPNPFNDPMTEQEAL AALTTKALLRTVARYRQLTPQMFATLNRIRLDVPSSHIRYLKATFDAKGFERNMTEREAL LALTAKSTIAAYRKFLFLTPQMIASLNNINLKSPNFSHIRFLRSHYPNPFSEPMTELEAL AALFTKSTVSAYRKYILLTPQIIASLNNIKLKPQHEDIHKLLRQRYPRGFDDKMTEREAL AALVASSGVRAWAVYKRLTPLAIAQLNGIKIISQLDSNLKFELNQYQGGFYRPMSEAEAL VALGLRAGLRARARYSGVPE------TLLNS------------RHYLGGFQHNMSRKEAL MILNITQKEIMSLNAPLLKKKHRLAMLKNHPDKGGSPYLSAKINEAKELLEKSVLTRK-M LILGISAREIEALDERLLRQKHRRAMIMNHPDKGGSPFIASKINQARDLLANSVILKGPM ------------------------------------------------------------ LILDISSKDIKKLDEKLLKRKHRGAMILNHPDKGGSPYLATKINEAREVLERSVLLRKRM LILDISAREINHLDEKLLKKKHRKAMVRNHPDRGGSPYMAAKINEAKEVLERSVLLRKRM -----------------------------------------------------------M LILDISAREINHLDEKLLKKKHRKAMVQNHPDKGGSPYIAAKINEAKELLGRSVLLRKNM LILDISAREINHLDEKLLKKKHRKAMVRNHPDRGGSPYMAAKINEAKEVLERSVLLRKRM LILNISPTEIEQSDEKMSKRKHRRAMVQNHPDKG-------------------------- LILQITGDEIKLLDRNMLKKKHRRAMLLNHPDKGGSPYVAMKINEARDVMEQSSLVR--M LILGISSEEIEHLNATMLKRKHRRAMLQNHPDKGGSPYLAMKINEARETLERGIMVNKNM LILGIEGNDILNLDKKMIRDRYRKLMILNHPDKNGSQYISQRINEAKDILDKSYMVNK-M LILGISGSEVAALDENLLKRKHRQAIVHNHPDRGGSPYLALKINEARDILSHSIMLKR-M MIMGIEGDEIMHMDKKLLKERYRKLMVMNHPDKQGSQYLSQKINQAKDILDKSYLFKK-M LILGIEGNDILNLDKKMIRDRYRKLMILNHPDKNGSQYISQRINEAKDILDKSYMVNK-M FILGIEGDDILRVDKRMVRDRYRKLMTRNHPDKNGSVYLSQKINEAKDILDKSYMVNK-M LILGIEGDDILNVDKKMIRDRYRRLMILNHPDKNGSQYLSQRINQAKDILDKSYMVNK-M LIMGINADDIASLTKDTLRKRYRKLMVMNHPDRHGSVYLSQKINQAKEVLEKSYLFRR-V LILGIEGDEIVNFNKKLLRDRYRKLMILNHPDKNGSQYMSQKINQAKYVLDNSYMFKNEM LIMGIEGDDIIKFDRAMLKERYRKLMVMNHPDKHGSKYLAQKINQAKQVLEDGYMFRR-- LILDISPNEIRNLDKKMLAKKHRKAIILNHPDKGGSPYLAMKINEAKDLISSSYLIRQ-M LILGF-AREHGSVTLNMLKDKHRKVMMLNHPDRGGSPFMAKKINEAKDMLEKEVKK---- VPPKKTVK-MDLNSFLNDDTFGS-SWAEDEVDLNKINIPIENT-SANTIPLEDIAAAKK- APPKKNAIKMDLSSFLEDETFNE-SWTADEVDLNNISIPIQNVAATNTISLDDFSRS--- ---------MDLTSFLNDDTFGS-SWAEEDVDLNKITIPIETA-NANTIPLSELAHAKNN APPKKNTVKLDLNTFLNDDTFGSKSWAEEDVDLNKISIPIENV-PANTVPLEEIAAAA-- APPKKTVKKMDLTSFLNDDTFGS-SWAEEDVDLNKITIPIETA-NANTIPLSELAHAKNN APPKKTVKKMDLTSFLNDDTFGS-SWAEEDVDLNKITIPIETA-NANTIPLSELAHAKNN APPKKTVKKMDLTSFLNDDTFGS-SWAEEDVDLNKITIPIETA-NANTIPLSELAHAKNN APPKKTVKKMDLTSFLNDDTFGS-SWAEEDVDLNKITIPIETA-NANTIPLSELAHAKNN ------------------------------------------------------------ APPKKNAIKMDLTSFLNDDSFGD-SWADDQVDLNNINLPIQNVAASNTIPLEQLGSAAMG APPKKTVK-MDLSSFLNDDSFGN-SWAEDEVDLNKINIPIQTVKPSSTIPLEEFA----- APPKKNVK-MDLGSFLADDTFGGGSWADEEVDLNTIGVSLETPAGSTAAPIGNVGGGNNT VPPKKSVK-MDLNSFLNDESFGE-SWAEEEVDLEKINIPIQSGRPQGIAPMESF------ AP-KKSVK-MDLGSFLSDNSIGG-SWADEEVDMSSIGVPIAGS--------QGTTGARKE APPKKNVK-MDLGSFLADDTFGGGSWADEEVDLNTIGVSLETSAGSTAAPIGNVGGSGG- APKRN--KKMDLGDFLKDESLGGSSWADEEVDMSSIAFSIENPAALTEAPIGGAPAFSG- APPKKNVK-MDLSSFLADDSFGG-SWADEEVDISSIGVSLDQPSYSTAAPIGGSGNTAT- PAPKKNVKKMDLGAFLADDSIGG-SWADEEVDMSSIGVATASA-----VPTGSYSREE-- APPKKTVK-MDLGSFLADDSLGGGSWADEEVDMSSIAVA-----SANAAPARELFGSSSG ---------MDLGSFWADDSYGGASWADEEIDMASIGVPTTGP-----------STGAST APPKKNVK-MDLNSFLNDESFGS-SWSEEDVDLNKINIPIESM-QANTIPLEDLVAVNK- ------------------------------------------------------------ -----AGAMGGMGMGGGRSRLDPALGGGAKSF-EREEYPVPNAPPYRAIINNIPWDISPE ----TAKGSGNRFGG---GKLDPAL------RKEREEYPIPDFPPFKAIINNIPWDITEI SNNMHSGGFGGSFGGGGRSRLDPALGGGVSDR--REEYPVPDAPPYRAVINNIPWDISPE ----RNQS------GRGGSRLDPALAGGRRDFQEREEYPVPEHPPFRAIINNIPWDISPE SNNTRSGGFGGSFGG--RSRLDPALGGGSSDR--REEYPVPDAPPYRAVINNIPWDITPE SNNMRSGGFGGSFGGGGRSRLDPALGGVVSDR--REEYPVPDAPPYRAVINNIPWDITPE SNNMRSGGFGGSFGGGGRSRLDPALGGGSSER--REEYPVPDAPPYRAVINNIPWDITPE SNNMRSGGLGGSFGG--RSRLDPALGGASSDR--REEYPVPDAPPYRAVINNIPWDITPE ------------------------------------------------------------ ----KGGHLDSALGS----------------KRERVEYPVPNAPPYRARISNLPWDVSKE ----PMGGSGGAGKG---SRLDPSLV---PERKERIEYPVPDHPPFRAVINNLPWDVSED ASAGSGFGSGSGSGF-----------GNDEFKRERKEFPIPDQPPYRARVSNLPWEVEES -------------GGGKGSRLDPSLVPERSERSERMQYDIPNHPPYRAVINNLPWDVQED GIYQPQTGFR----------------DNDDSRRERKEFPVPDQPPYRARVANLPWDVEEQ INNTTSTGF-----------------GNDEFKRERKEFPIPDQPPYRARVSNLPWEVEED ---TSGAGAGAGAGG--------------FERRERVKYPVPDKPPYKAYVNNLPWDITEQ ---ATSGGSGFASQA-----------VNEEFRRERKEFPIPDQPPYRARVSNLPWETDED --------------------------SEDYPRRERTEYPVPDAPPYKARVANLPYDASED FGRDSGFGREGGFGE-----------GGFDERRERKEFPIPDQPPYRARVGNLPWELTED STYKRQESFGSS--------------RFEDQRQDRQEYPIPDEPPYRARVGNLPWEVTED -----KSSFGGSSSGYGASRLDPALQGAKRDF-QRTEYPVPDSPPYRAIINNIPWDITPE ------------------------------------------------------------ GVQAWVEDGLGKEGAVEEVSLPKSIKDPTRLKGIAFITLKEREDLVKALTFNSTKLNERT GIQQWVEDGLNKEGAVLEVMAPRH-PDNDRLKGMAFVTFNERSDLEKALTFSSSKLNDRT GVQAWVEDGLVKPEAVEEVVLPKNLRDPTRLKGNAFITLKEKEDLVAVLKFNGTKLNERT GVKAWVQDGLNNQEAVEDIDLPVSMKDPSRLKGLAFVTLKERSDLVKALTFNGTKLNERT GVQAWVEDGLVKPEAVEEVVLPKNLRDPTRLKGNAFVTLKERADLVAVLKFNGTKLNERT GVQAWVEDGLVKPEAVEEVILPKNLRDPTRLKGNAFVTLKEKADLVAALKFNGTKLNERT GVQAWVEDGLVKPEAVEEVILPKNLRDPTRLKGNAFVTLKERTDLVAVLKFNGTKLNERT GVQAWVEDGLVKPEAVEEVVLPKNLRDPTRLKGNAFVTLKEKADLVAVLKFNGTKLNERT ------------------------------------------------------------ GVHAWTEDMLERPGCVEKVIAPKD-QDSDRLKGWAFVTFRERDDLVKSLTLNAPKLNDRT GIKAWFEDGLQQPGSVEEVAAPRDFNDPSRLKGFAFVTLADRKSLEESLKFNATKLNERT NVIRHFEDRMQAKDIISDIVLPKD-RDTGRLRGFAFVTFNDRALLEESLNLSMTEFQGRK GIKAWFEDGLQRPGAVEDVAAPRDYNEPTRLKGFAFVTLCDRDALEASLKFNATKLNERM DLGRFFEDRMQVQDVITDIKLPVD-NMTGKLKGFGFVTFTERGLLEEALNLNMADLNGRK IVIRHFEDRMQAKDIISDIVLPKD-RETGRLRGFAFITFNDRGLLEESLNLSMTEFQGRK DVIRHFEDRMQANDIISDIKLPLD-RETGQIKGVAYVTFTTRELLEESLNLSMSEFNGRR GIVRHFEDRMQAQGIISDVVLPKD-RETGKLRGFAFVTFNEREILEESLNLSMSEFQGRK ALARFFEDRLQARDIVEDVKLPMD-MMSGRPKGFAFVTFTEREVLEEALRLTMSDFSGRK DVVRHFEDRMQAEDIISEVKLPQD-RDTGRLKGFAFVTFNERDALEDALQLNLSDFNGRK DLARFLEDRMQTRDAISEIKLPVD-TMTGKLRGFGFVTFKDRDVLEESLRLTLSDFNGRK GVQAWIEDGLQKPGAVEELSLPRDMRDPSRLKGLAFVAFKEREDLVTALTFNATRLNDRT ------------------------------------------------------------ VYVSVAAPRREGFRSGGDDF-DWGSARGSGFQAS-----REEP--NLDWGAARGSGFQPE VYVSVAAPRSNGGRSNFDDM-DWSGARGSNFREG-GR--EAGP--EPDWSAARGSNFR-- VYVSVAAPR----RMGGDDV-DWSSARGSNFQGD-GR--EDGP--DLDWGAARGSNFRG- VYVSVAAPRRDGYRSGGGDF-DWGAARGSNYEAS-AD--RNGP--ELEWGAARGANFQ-A VYVSVAAPR----RGGGADV-DWSSARGSNFQGD-GR--EDAP--DLDWGAARGSNFRG- VYVSVAAPR----RMGGADV-DWSSARGSNFQGD-GR--EDAP--DLDWGAARGSNFKG- VYVSVAAPR----RMGGADV-DWSSARGSNFQGD-GR--EDAP--DLDWGAARGSNFRG- VYVSVAAPR----RMGGADV-DWSSARGSNFQGD-GR--EDAP--DLDWGAARGSNFKG- ------------------------------------------------------------ VYVPVAAP-----KDGVFDESNWNGARGANFQAS-G---EDPV--DLDWGAVRGSNYH-S VYVSVAAPPKD-----GFRG-DRRMG-GGSF--------E-----DFDWGSARGSNFH-- IYVNVAAPPK------GEDG-DWRAGRGSNRRGGEDR--EPAP--ELDWGAARNSQA--- VYVSVAAPPKGGDRMGGFDDMDWGAARGSAFQSS-NR--REEV--DIDWSSARGSGFH-- IFVNVAAPQ----RADVFDM-DWRSARGGPMEG--GRPPREEV--EIDWSSARSSGG--- IYVNVAAPPK------GEDG-DWRAGRGSNRRGGEGR--EPAP--ELDWGAARNSQA--- MFVNVAPPQQGGSRGGGADL-DWGAARSSSFGGDRGRPPREEP--DLDWGSARGTRA--- IYVNVAAPPKE--SEG-----DWRSGRGGNASSR--R--EPAV--ELDWGSARNSRA--- IYVNVAAPQ----KADVFDM-DWRANRTGPIGG--GR--REEP--DLDWGAARSSG---- IFVNVAAPQR------DFDG-EWK--RGSGVGGG--RTGEDEP--ELDWGSARNTRA--- IFVNVAAPQ----KQDVFEM-DWRASRG-PLTGGSGRDRGDRPEVDIDWTSARGQGT--P VYVSVAAPRKDGYRNGGDEF-DWGGARGSNFQRD-E---SSAP--DLDWGAARGSNFT-- ------------------------------------------------------------ SRPRRED-PDL---DWGSARGSGFQASR----ESR-PRR---EE---PDLDWGSARGSGF ESRTREAGLEP---DWSSARGSNFRE-------PREPRE---PV---PEPDWSSARGSHF PRREREE-VDI---DWSAARGSNFQN-------SR-PPRREREE---VDIDWTAARGSNF SRPRRDDGPDL---EWGAARGSNFQA-------SR-PPR---EE---PNLDWDAVRGSNF PRREREE-VDI---DWTAARGSNFQGS------SR-PPRREREE---VDIDWSAARGSNF PRREREE-VDI---DWTGARGSNFQNS------SR-PPRREREE---VDIDWTGARGSNF PRREREE-VDI---DWTAARGSNFQNS------SR-PPRREREE---PDIDWTAARGSNF PRREREE-VDI---DWTAARGSNFQNS------SR-PPRREREE---PDIDWTAARGSNF ------------------------------------------------------------ ERKPRREDPDL---DWTTSRGSNFRPS------EHKPAQ---QE---SDVPWSVAKGYNF -----------------AAK----------------PRR---ED---PDLDWGVARGSNF ELPPRQRS---------NRLGSGSGPSGESSSSSR-PSR--RQE---AELDWGSARNSRD ASKPRGDDVDI---DWGSARGSGFHA-------SK-PRR---EE---PDIDWSSARGSGF -LPPRENRGDR------GDRPER-----------R-PRR---EE---PDIDWTSARSAGG ELPPRQRS---------NRVGSGSGPSGES---TR-PSR--RQE---AELDWGSARTSRD ELPPRER----------SFRGDREDRG------DR-PPRKQREE---PDLDWGSARGTRA ELPTRQR----------SNRNIESDQSNENNTPTRAPRR---QE---PELDWGSARGAKI PR--------------------E----------RK-PRR---EE---PDLDWGSARGSGV SLPPRER----------SDRGDRPDRGDRP---ERTPRK---EE---PDLDWGSARHSQA PREPRDR----------MDRGDR-------------PRR---EE---PDIDWSSTRGKGV ERKPRREEPNL---DWGVARGSNFSE-------RK-PRR---EE---PDLDWGVARGSNF ------------------------------------------------------------ Q-GS----RDRED---RPKREEPNLDWSAARGSGFQASRQRE-----------------D R-EA------REP--REPREPVAEPDWTSARGSHFKEA---------------------R Q-NS-----SRPP---RREREEPDIDWSAARGSNFQTS-SRP-----------------P Q-AS------RPP------REEPNLDWDAVRGSNFKASSSRP------------------ Q-GS-----SRPP---RREREEPDIDWSAARGSNFQSS-SRP-----------------P Q-NS-----SRPP---RREREEVDIDWTGARGSNFQSS-SRP-----------------P Q-NS-----SRPP---RREREEPDIDWSAARGSNFQNS-SRP-----------------P Q-NS-----SRPP---RREREEPDIDWSAARGSNFQNS-SRP-----------------P ------------------------------------------------------------ Q-SS-----ERKV-----RHEEPDIDWTVARGSNYQ---SRE-----------------R QAPR-----ERQP-----RREEPDLDWGVARGSNFQAP--RE-----------------R GLPPQRERSNRTP-----RKQEPEFDWNTARNTQAELPVRRP--QRENPDGTPRENSTRQ E--------ERRP-----RREEPNIDWSSARGSGFEE----------------------R L-PPREDRGDRGEPERRPRREEPDLDWGAVRSSAGTLP-PRE--KSGRGERVERGERSER GLPPQRERSNRTP-----RKQEPEFDWNTARNTQAELPVRRP--QRDNFDGTPRDNSSRQ ELPPREDRGDRPP-REFKRKEEPDLDWSSARGSQAELPPRRPHDRENNTTNNSDEFGHSR D---------LPP------RQRSNRNFNNNDENNNATP---------------------R L-PP----RERRP-----RRDEPDLDWSSARGSGVLPP--RE-----------------R TLPP----RERSN-LERPKKEEPELDWGSARTTHATLP-PRENRDRGDRPERGDRPERGE L-PP-REPRERSD---RPRREEPEIDWSSARGQGSLPP-REP------------RERSIR S--------ERKP-----RREEPNLDWGVARGSNFAE----------------------R ------------------------------------------------------------ RPKREEPNL------DWGAARGSGFQ-ASRQ--------REDRPK--------------- EPREAVPEP------DWSSARGSHFKESKPRAPEPDWSSRDQKPRSPEPDWSDARGSHFK RREREEVDI------DWSAARGSNFQNSSRP--------PRRERE--------------- --PREEANL------DWDGARGSNFK-AQQS--------QRKPRN--------------- RREREEPDI------DWSAARGSNFQSSSRP--------PRRERE--------------- RREREEPDI------DWAAARGSNFQSSSRP--------PRRERE--------------- RREREEPDI------DWSAARGSNFQNTSRP--------PRRERE--------------- RREREEPDI------DWSAARGSNFQNSSRP--------PRRERE--------------- ------------------------------------------------------------ KPRSDEPDL------DWGAAKGSHYQAAKSR--------PK------------------- QPRREEPDL------DWGAVRGANFSQQ-----------PRRERKPR------------- TPRKQEPEF------DWGAARNTK---TSLP--------PRERLNRTGSNSGKK------ KPRREEPVI------DWSSARGSQF--TERQ--------PRVERKP-------------- RPKKDEPEF------DWGAARSSA---GTLP--------PRERSTRTERQDK-------- SSKRQEPEF------DWSSARNTK---ANLP--------PRERLNRTGSNNGKK------ PPRKQEPEL------DWGAARNSH---VELP--------SRERSNRSFHNKNHENNHAAG TPRRQEPEL------DWGSARSTR---AELP--------VRERSKRNNSYNNKDSTTTTQ RPRRDEPEL------DWGSARGS----GVLP--------PREHSRREFRK---------- RPRKQEPEF------DWGSARSGA---GGLP--------PREKSFRSDRPK--------- TPKRDEPEF------DWSSARGS----GTLP--------PRERSNRTPK----------- KPRREEPDL------DWGAARSA----SGRS--------FKERKPR-------------- ------------------------------------------------------------ ---KEEPSLDWGA-ARGAQFNKATQ--QGTKKNAAP------AKAPEETPK-IQKSAFDV ESKQRGPDIDWSA-ARGTKFGRQSES-TPAPKKSYSRKENAQQQKPEETPK-VVKSAFAV ---REEPSLDWGA-ARGSQFGKNQQAKSSHKDKAASN-----KKPTEEQPK-IQKSAYDV ---NDEPELDWGA-ARGSNFGKKTTSNTQKTTTSRFNRTEKTAEATTEAPK-VQKSAFDV ---KEEPALDWGA-ARGAQFGKPQQTKNTYKDRSLTN-----KKTTDEQPK-IQKSVYDV ---KEEPALDWGA-ARGSQFGKPQQAKNSYKDKTTPD-----KKTAEEQPK-IQKSTYDI ---REEPALDWGA-ARGAQFGKPQQAKNSFKDRSTSN-----KKTAEEQPK-IQKSVYDV ---KEEPALDWGA-ARGAQFGKPQQVKNSHKDRSLSN-----KKTTEEQPK-IQKSVYDV ------------------------------------------------------------ ---RNGHELNLGA-ARSAKAAPQVARKSTT------------PALKEDTPR-IQKSSYDI ---SDEPQLDWGS-ARGSNFGQQQQQKQQQKPRRSKFES---APAAEEKPK-IQKSAFEV ---STEPDFDW---KRGQSLPSRNVSRSSGNRKDVK------KDEQQNQPQKPQKSHFSV ---RDEPNLDWGV-ARGAKFGQRSNSRNTTKTQGSATKA---SGSVEETPK-IKKSAYAV ---KQEPALDW---KRGQGLEPRSNSKPSRANKKVD------EEKKDNQPK-PQKSSFDV ---SIEPDFDW---KRGQSLPSRNVSRSTGNQRNVK------KDEQQNQPQKPQKSHFSV TRKSSELDLDW---KRGQPLPQRTRSSQNTKSRKDD------KKKEDEKVQGPQKSQFSV --KPSEPEFDW---KRGQSLPSGRRSTSTSTNKKDDK-----KEEQSSQQQGPQKSHFSV ---KDEKEFDW---KRGQALEPRAK--KAAPKT---------AEKEKDQPK-PQKSLYDV ---KQEPSLDW---KRGQALPAKTKASSTGGSKQQK------KDDKKEEPK-PQKSSFSV ---KAEPVLDW---KRGQTVEPRKPKKDTSK-----------PEEEKEQPK-AKKSLYEV ---KDEPDLDWGA-ARGSNFSERKPR-TDRTDRAA-------TEVVEEKPK-MQKSSFSV ------------------------------------------------------------ LRDEDDEDDETEST-----TAQQN--SGDVEKLTEETKQLNVTE----DDGDWEVVGKK- LSTEDDDEDEDETEQD---QNQEQKTADDVEVLEKSTKGLSIDQD---DNEEWETVGKK- LRTEDDDEDEDVAEKQNE-DVKESKTDAGVENLQEKTAQLTVE-----DGDDWEVVGKK- LRTEDDDEEEEEEQEPVK-EEKNN--TSDVNQLAKETANLNVA-----DDSEWEVVGKK- LRTEDDDEDEEAEKQNG--DAKENKVDAAVEKLQDKTAQLTVE-----DGDNWEVVGKK- LRTEDDDEDEEVAEKQNE-DAKENHTDAAVEKIQEKTAQLTVE-----DGDDWEVVGKK- LRTEDDDEDEDAEKQSG--DAKENNADVTIGKLQEKAAQLTVE-----DGDDWEVVGKK- LRTEDDDEDEEAEKQNG--DAKENKADAAVGKLQEKTAQLTVE-----DGDDWETVGKK- ------------------------------------------------------------ LNVESDSEHDAETSGQNS-QPDDD-----VAHLEKAAQNLTLE-----EDGEWEVVGKKQ LAVEDDEPEHEQPQQHQQPPAKSD--DVNVTKLEKSAAQLSLET----DDGEWEVVGKK- LNVEGEDEDEEEDEKK---EVKES--KQQIDNLQQATSKLTVSEGQE-DGEGWEVVRK-- LSTEDDDEEAPETE-----DSTPKPKQDEVAELSQTTAKLSVGDD---DDQEWETVGKKS LTVESDDEEAQPAK-----NAEEPKAEQTTTGLEDATSKLSVNNK---EGEGWEVVGK-- LNVEGEDDEDEEQEQEEEQEEQVQKSKQQIDNLQQATSKLTVSEGQE-DGEGWEVVRK-- LAVDDEEEHEEEPREPKE-ENATK--DVNNESLESATAKLSVSDNKSENADEWEVVGKK- LDIEDEEDEEEHKE-----ETQSK--QTQVEDLTEKTADLSVHD----DNDGWEVVRK-- LSLDDDSEEEKEE------EKKEEPAEKTETGLEDKVANLTVE-------EGWETVGK-- LAVEGDSDEEEKDEEPVS-QPTEE--ASTETGLESATANLSVQETK--DSEGWEVVGK-- LAVEGDGDDESDDE-----PVAKKTGDDAVSALESKTSELSVD-----EKEGWSTVKK-- LSNDDEEEEEEET------TIQEATPVEEVTTLEKEAAQLSIDDK---DDGEWEVTGKK- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MSFENTRTSKVIFDFFDHYYTNNISNSSN ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MTHTERQKVTFEFFDNTSHQMQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MTHTERPKVTFEFFDNTSHSMQ-------- SSNSSNDINDINDINDINDINDINDSNDSMDIQQYQPLPQNKIHQARETD---------- --------------------------------MNNNPKVTFEFFDSHNNSMQQ------- ------------------------------------------------------------ ----------------------MTAPKVTFDFFDMTPPNESYIQMAGGH----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------MLYTFYSSFLSDHISFLHEYFFSRIKVFILY ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITRLFLQTIPISIFHNYNTMSFSSQEDIFDDTF--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ -----------------------MSRPNENLRPELLRSLESRKHLNSRTVSTNTSTNSLF --------------------------------MCGSSDSDSHDGYLTSDYNSSNSLFSLN ---------YKFFGMHIPNPAPIEIYSLQNEGNNPYDALQQSCLHSSTTNLDQTPVNDLL --------------------------------MGGSSDSDSHDGYLTSEYNSSNSLFSLN --------------------------------MTGSSDSDSQDGYLTSEYNSSNSLFSLN ------------------------------------------------------------ --------------------------------MGGSSDSDSHDGYLTSEYNSSNSLFSLN ------------------------------------------------------------ -------------------------------------------MTDREGPLPSNALRSHS ----------------------------------MGRAEPLRSNSTSTNSLFSLHRSSYS --------------------------RNKLKQLPPLSTDIESSSSPHSPSGADLRFISSS ----------------------------------------------------------ML --------------------------MDTLPYHEAPKGREGNFTKKNEPEEGQTPSNSYE --------------------------RNKLKQLPPLSTDVEASSSPHSPSGADLRFISSS --------------------------DGDSHQEDIFSTSSTTSVNSLFDFPTASTSTTTP --------------------------PQRNKQLPPISTDYEYSSSPNSPNPMGLRFINSS ---------------------------MSLFRFTTPPSPPLEYQMPKTGETHMRQTREAL ------------------------------GSPSNSNSKRPEKITISSSTSDMKLIDSTS ------------------------------------------------------------ -----------------------------------------MSDSTSSPRLETLKSNHTS ------------------------------------------------------------ --------MQELSSAESSTNSLFSMKSISSMDISRNTTPRPSPLGAAMSTNDQSFLSLAS SLHGSSSSSIYPTISHTETEIDVSNHTDGYFAGLQGSSSANHAANNSYLSQGSSLTIQFG NGNSYSSASLDRATFDCQDSDLLGNHKHPMLSTEIPRFISNDALHSPITLNYKRDNDDVT DNISREAEPSDIEINNSSSSPSSVRGRSYDSFCGIPSYDSPITKPSSFYNDLQLRADTTS TGNSYSSASLDRATLDCQDSVFFDNHKSSLLSTEVPRFISNDPLHLPITLNYKRDNADPT NGNSYSSASLDRATLDCQDSSFFDNHKNSLLSTKVPRYISNDALHLPITLNYKRDNDDVT ------------------------------------------------------------ TGNSYSSASLDRATLDCQDSDYFDNHKSSLLSAEVPRVISNDPLHLPITLNYKRDNADAT ------------------------------------------------------------ TSMNSLFSFQNENSYSSILEYYDGAAESPPPSLTQEAGEEGSPLTLNYDGRHWNALREAP SIIDHYCEEEEESQETQLGQPLPHPIVTTAITSQDEEATPITPSQSPLTLNYRSRRRSVW SSINSLFDSVPLYSRTASTTTITPILSRHDSNPGFKNNYHNLLHHPTIQELDFTQTIDLK SEELYDSGSTATSTNSLFSLNKRGSYTSVVDCYLDEAEDEPTALTLNLSSRNRRSSVAGP VNGFERIGSNTSINSLFDSNEYYCDAFKTNATQTAASSMISTPFLLTLKENILEVEDFNT SSINSLFDSVPLYSRTASTTTITPILSRHDSNPAFKNNYHNLLHHPTIQELDFTQTIDLK ILSRNESMKQKFINPGYKLTPSIEEFTTKLDKKLNQQLRKTTINSNSTTSNTTNKNVSTN SSLNSLFDNAPPYIRSTSTATITPVLSRNDSNLFKNNYSLTQQFHPTIQELDFTKTIDSK NTKEMLSKDTSYPYLSTKQSMPRAVQNASPEKGGKPDILRPAALPTPLQSRTSTTSLGSL SINSLFDNVGNSYSKNTTTATSPVISRVDLNFFSSGTNSAANSFANPYLVPRLSPLEFTS -MDIEMNPMNPRATKMRTSSSQSSASAVMDANTGATTFDSTPATSINKYHFSPQELEEWI TNSLFSLSKKSYSSLLLNNSNYYYENEEFDDVDDSYSSKNRDIFTYPYNQYSSGLLTPAP ------------------------------------------------------------ IRREMD-------RESKKDKFIVILVGLPASGKSSISSHLIQSLKN-NTATAHLRSTVYN NKRQNL-----------NHKFCVILIGLPATGKSTISRHLINFLHS-SRSTAHLRCSIFN YTNGKI------------NKFMIVLIGLPATGKSTISSHLIQCLKN-NPLTNSLRCKVFN PLTLLK----------AK-KYLVVLVGLPASGKSSVAKHLIDYLDQNNVLGQPIRSGIYN YTNGKV------------NKFMIVLIGLPATGKSTISSHLIQCLKN-NPLTNSLRCKVFN YTNGKV------------NKFMIVLIGLPATGKSTISSHLIQCLKN-NPLTNSLRCEVFN ------------------------------------------------------------ YTNGKV------------NKFMIVLIGLPATGKSTISSHLIQCLKN-NPLTNSLRCKVFN RRQKKP-------------KYVFVLVGSPAVGKSSTSSHLIEYLSR-QPSTKDLRCEVYN VLQGTE-------------KFLVVLVGLPAVGKSTISGHLIRFLQN-NPRLSHLRCGVFN LHQQND---------SHRDKFVVVLIGLPATGKSTISNHLIQFLKS-SPSTAHLRCSIFN LRQHQS----CTTSAQPKEKLILLLVGLPASGKSTICKQFQEFINE----NSEYNAQIYN APRAND-------------KLVVILVGLPASGKSTISNHLIQYLGH-DPATRHLRCKTFN LISKKL----------NFNKTIIILVGLPASGKSTISKQLCSYFDQ-----KNFKSKIYN LRQHQS----CTTSVQPKEKLILLLVGLPASGKSTICKQFQQFINE----NSEYNAQIYN TSTRNN-------THELKSKLVVLLVGLPASGKSTLCHQLNSYINN----YTQYTSRIYN LLKHSQ------EQQKQQQKLIVVLVGLPASGKSTVCKQLETFINT----TTPFSSNIYN FAPAPTEVCDTVQRRLGP-KSLVMLVGLPASGKSTVCNYLAQHLEA-----HDYKALIYN LVNEKL--------ISQHEKLVIMLSGLPASGKSTISRQLKNYINA----TSNFTAEIYN TKKHKT------------ERTVVMLVGLPASGKSTIARQLSRFLQK-----SGYKCDIFN STEKLD-------------KYVFILIGLPASGKSSISSHLIKYFNS-NDSTKHLRCSIYN ------------------------------------------------------------ AG-----------KVRRM------------------------------------------ AG-----------NVRRK------------------------------------------ AG-----------KIRRQ------------------------------------------ AG-----------DVRRS------------------------------------------ AG-----------KIRRQ------------------------------------------ AG-----------KIRRQ------------------------------------------ ------------------------------------------------------------ AG-----------KMRRQ------------------------------------------ AG-----------KVRRS------------------------------------------ AG-----------QVRRD------------------------------------------ AG-----------HVRRK------------------------------------------ AG-----------DVRRR------------------------------------------ AG-----------QVRRK------------------------------------------ AG-----------DIRRR------------------------------------------ AG-----------DVRRR------------------------------------------ AG-----------DVRRR------------------------------------------ AG-----------DVRRR------------------------------------------ AG-----------VVRRN------------------------------------------ AG-----------NVRRM------------------------------------------ AG-----------DVRRK------------------------------------------ AG-----------QVRRN------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LCNGEKK- ---------------------------------------------LSTRRQVSPFMAPE- ---------------------------------------------------ISCATISK- ------------------------------------------------SVIITNGPIII- ---------------------------------------------------ISCATISK- ---------------------------------------------------ISCATISK- ------------------------------------------------------------ ---------------------------------------------------ISCATISK- ---------------------------------------------------MSFQNLGL- ---------------------------------------------------LTYSGRSM- ---------------------------------------------------LSCKGRPM- ----------------------------------------------------RSASEFN- ---------------------------------------------------LSCRGRPM- ----------------------------------------------------LKHNSFN- ----------------------------------------------------RSASEFN- ----------------------------------------------------KSLGIFN- ----------------------------------------------------KSCSEFN- ------------------------------------------------------ARAPA- ------------------------------------------------------NKSFD- -----------------------------------------------------MHQQLS- ---------------------------------------------------LSNNGLPM- ------------------------------------------------------------ ---------------------------K----SIQIANDPSEDLFNP-----ANAERKEV ------------------------------------LNKSEEDVFNP-----KNSHKKEE ---------------------------P-----LLLSNTSSEDLFNP-----KNTDKKEA ---------------------------P--------NGSVEDDIFNP-----RNAKKKEE ---------------------------P-----LLLSNTSSEDLFNP-----KNNDKKET ---------------------------P-----LLLSNTSSEDLFNP-----KNNDKKET ------------------------------------------------------------ ---------------------------P-----LLLSNTSSEDLFNP-----KNNDKKET -------------------------------LSMRLANDSSEDLFNP-----KNHDKKEL ----------------------------------KLANSSGEDLFNP-----KNSDKKNM ----------------------------------MLANNSSEDLFNP-----KNSEKKEK ----------------------------------------DAQFFDP--NNEQGKKDREL ----------------------------------MLANNSSEDLFNP-----KNAQKKEQ ----------------------------------------SSDFFDP--NNLKAKHEREV ----------------------------------------DAQFFDP--NNEQGKKDREL ----------------------------------------DSRFFDP--KNKEARQDREL ----------------------------------------DAKFFDP--NNEQGKKDREL ----------------------------------------GADFFDP--QNVQAAALREQ ----------------------------------------NSDYFKP--DNVQGKIDREK ----------------------------------------TSEFFDP--DNVTAKRQRDT ----------------------------------KLANDSSEDLFNP-----KNSNKKEK ------------------------------------------------------------ YAKITLENLINEL-----DSDICDFAIFDATNSTVQRRSFVFREIYKYN----------- YARIALSKLLNDL-----KQDRCDLAIFDATNSTLQRRNYVLQEIRSFNKAQYDKHNARR YARITLQKLFHEI-----NNDDCDVGIFDATNSTIERRKFIFEEVCSFN----------- FARVALDSLLHDM-----ANDVIDLAIFDATNSTIERRNYIWNVLRTFN----------- YARITLQKLFHEI-----NNDECDVGIFDATNSTIERRRFIFEEVCSFN----------- YARITLQKLFHEI-----NSDECDVAIFDATNSTVERRKFIFEEVCSFN----------- ------------------------------------------------------------ YARITLQKLFHEI-----NNDECDVGIFDATNSTTERRRFIFEEVCSFN----------- YARITLEKLLKDL-----DSDECDVAIFDATNSRVNRRRFVFEEICSYN----------- YARITLERLFREL-----DADRCDIAIFDATNSTISRRRFIFQQVHEYN----------- YARITLEKLFNEL-----DMDLCDVAIFDATNSTEKRRSFIFEGIRAYN----------- YATITVNNLINDL-----QSNVIDVGFLDATNTTLERRQRMINLINEQV----------- YARLTLEQMFGDL-----DQDLCDIAIFDATNSTEKRRAFLFQEIRTYN----------- FATTSLSTLIHDL-----NQGNISVGFLDATNTTLERRNKIMQYIRETP----------- YATITVNNMINDL-----QSNVIDVGFLDATNTTLERRQRMINLISEQV----------- YASIAISNLIKDITSPPQNKNSIDIGFFDATNTTKDRRQRMLETIHTNN----------- YATITVNNLINDL-----NSNLFDVGFLDATNTTIERRNRMINKLHESI----------- YASAAMTTLLSDL-----AHSRISVGFLDATNTTAARRKRMLEMALSSG----------- YADITVNNLINDL-----NSNVIQVGFLDATNTTIERRKRMMDIISKNT----------- FATMAMTDLLSNL-----QDEVINVGFLDATNTSIERRKSMIEMSRQAG----------- FAKITLNNLLRDV-----NNDACDIAIFDATNSTKARRKFLISEFSYYN----------- ------------------------------------------------------------ ---------------------DREGANFNLIPIVFQVTCSNQDFIRYNI--HNKTF-NED SNNKNRARGDDIDEDEYEDEADDRADAIHITPIFLQVSCTDPNFIKYNI--HNKTF-NQD ---------------------TDELSTFNLVPIVLQISCFNRDFIKYNI--HNKSF-NED -----------------------NESNIMVTPLVLEVSCDKSEYIKYNV--HNKAF-NKD ---------------------TDELSSFNLVPIILQVSCFNRSFIKYNI--HNKSF-NED ---------------------TDVLSTFNLVPIILQVSCFNRDFIKYNI--HNKSF-NED ------------------------------------------------------------ ---------------------TDELSSFNLVPIILQVSCFNRSFIKYNI--HNKSF-NED ---------------------QMRNKKICITPIVLQISCNDHDFFKFNV--HNKAF-NAD ---------------------TRLGSDINITPIVLQVTCNDENFIRFNI--HNKTF-NQD --------------------SNKRGHQFQITPIALQVTCSDKEFIKYNI--HNKTF-NQD ---------------------------PNGRIVIFDVQCNNQKLLEYNI--SGKSE-NND ---------------------ADLSRDFHVTPLVLQVSSTERNFIRFNI--HNKTF-NQD --------------------------TRADNVILMDIQCNDQTLINFNI--SGKAF-NAD ---------------------------PNGRIVIFDVQCNNQKLLEYNI--SGKSE-NND ------------------------TQNVQLRTVILDVQCNNQHMIDYNI-CQGKVY-NAD ---------------------------PQGRIIILDVQCNDDKLLNYNI--SCKSN-NND --------------------------VNFANIYVLDVACTDAQLLEHNI--ARKAG-NVD ---------------------------TNTWVAIMDVQCTSKRFINFNI--SGKAH-NND ---------------------------IVDHFIILDVACDIEEYLLFNI--NGKAF-NAD ---------------------SNVNSSFHIIPIFLQISCNDINFIRYNV--HNKSF-NDD ------------------------------------------------------------ Y-FDKPYEV--AVQDFSKRLKYYHSQFVPF---TET-------------EFNTIIES--- Y-YDKPYEF--AVKDFAKRLQQYHSQFVQFSRSEFD-------------HYCK-ENA--- Y-LDKPYEL--AIKDFAKRLKHYYSQFTPF---SMD-------------EFNQIHQY--- Y-CGNPYSS--SILDFAKRLLYYKKQFTPF---NEI-------------EYPLLSSA--- Y-LDKPYEL--AIKDFAKRLKHYYSQFTPF---SLD-------------EFNQIHRY--- Y-LDKPYEL--AIKDFAKRLKHYYAQFTPF---SVD-------------EFNQTHRY--- ------------------------------------------------------------ Y-QDKPYEL--AIKDFAKRLKHYYSQFTPF---SLD-------------EFNQIHRY--- Y-YDKPYEY--AVRDFAKRLKNYHLQFTPF---TRR-------------EFGQLSSL--- Y-FDKPYEY--AVRDFAQRLKHYYTQYVPF---TED-------------EFTTTIEA--- Y-FDKPYEF--AVQDFGKRLKHYYSQFVPL---NKR-------------EFEHYLFD--- Y-KNKDYTT--AINDFKQRAMNYKKIYKPI---TEE-ELASYGDK--VDMYMKCVNG--- Y-FDKPYEF--AVRDFARRLAHYHSQFIPF---SIP-------------EFNQQMAE--- Y-KGKDYNT--SVRDFKERSKHYIKIYDPI---SEE---ELASYRGVASLYVQIVNG--- Y-KNKDYTT--AINDFKQRAINYKKIYKPI---TDK-ELDSYGDK--VDMYMKCENG--- Y-ANLQSEKSLAVRDFKQRLQHYREVYEPV-------------------SWQELDAY--- Y-KDKDYSM--AIRDFKARSMNYKKAYQPI-------------------TSVELENY--- Y-RGRSADE--AVRDFRRRAAHYAQIYEPV---SRE------EVARFGATYIRIQDA--- Y-KGRNYAE--AVRDFKKRSEHYYKVFEPI---TSE-----ELELYPLAVYLKIVNC--- Y-RNINHEV--AIADFKKRTKHYYKAYEPL---TKE------------------------ Y-YDKPYRY--SISDFAKRLRYYCKQSTPF---SEI-------------EFEEISSY--- ------------------------------------------------------------ -----------NSSQTAGKPSLYYY-------------------------------NILN -----------RVNEGSHNPNFGLFFF-----------------------------HIMN ----INGH-------EEIDASLFFF-------------------------------NVIN -----------------SNGNIFHF-------------------------------RISN ----ISQH-------EEIDTSLFFF-------------------------------NVIN -----------ICQHEEIDTSLFFF-------------------------------NVIN ------------------------------------------------------------ -----------ISEQEEIDTSLFFF-------------------------------NVIN ------------VQRRGLDHGVFCF-------------------------------NIVN -----YMHIEGRTPGTYRGSLFFFSIIN-----------------------AGLDTDLSA -GTLSQDN-----------SGLFFF-------------------------------NIIN -GQQFEFS---HIH---------------------------------------------- -GKLINDD-----------NGLFWF-------------------------------SIIN -GKKFKFT---DIP--------------------------------------GSNEVDIQ -GQQFEFS---HIH---------------------------------------------- -DDQELIT-------AYVKC---------------------------------------- -GDKIDMY---------------------------------------------------- -GRAVSMA---------------------------------------------------- -GESFELK---NVDPGFKEYLQLY------------------------------------ -----------EID-GF------------------------------------------- ------------LKENNLEYEVLYYKIC--------------------------DAGLSN ------------------------------------------------------------ AGLDPSKQFQLSYT---------------------------------------------- AGQFSADDSNMYYFP--------------------------------------------- AGIVEPHSLNHSHYP--------------------------------------------- AGISSVGNMIMFNKD--------------------------------------------- AGVVEPHSLNQSHYP--------------------------------------------- AGIVKPHSLNQSHYP--------------------------------------------- ------------------------------------------------------------ AGVVEPHSLNQSHYP--------------------------------------------- AGTVPTRD---------------------------------------------------- PKVGFAPQI--------------------------------------------------- AGLLDTRELNCFHFP--------------------------------------------- ------------------------------------------------------------ AGESSNTNFSACHFP--------------------------------------------- TENDVLTCLTDFIKN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SNQNFVLST--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------STCGR------------------------- ------------------------------------------------------------ ------------------------------STCGK------------------------- ------------------------------STCGK------------------------- ------------------------------------------------------------ ------------------------------STCGK------------------------- ------------------------------DNFGV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PHATK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------INAGE------------------------- ------------------------------------------------------------ ------------------------------AGSGD------------------------- ------------------------------KVISE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RESETHSMIVKETLRVISHFV---------------------------------- --------SQYCSDTAELINTMEYFM---------------------------------- -------------QIRDTIMVVENFI---------------------------------- ---------IFDLETNLLIREIEKFS---------------------------------- -------------QIRDTIMVIENFI---------------------------------- -------------QIKDTIMVIENFI---------------------------------- ------------------------------------------------------------ -------------QIRDTVMVIENFI---------------------------------- -------LPVQKEQVQTVINLVAQFV---------------------------------- -----------SSAVAEVVAAFGDFV---------------------------------- --------SQYSNAVGEVVNAFEYFV---------------------------------- ------HADTW------------------------------------------------- -------------LLILLINSIKKFV---------------------------------- ------------------------------------------------------------ ------HADTW------------------------------------------------- ---------VFDVSLGKNVTAHEEEE---------------------------------- ---------------VKCVNAGETFD---------------------------------- ------------------------------------------------------------ -------------------FASQYYD---------------------------------- ----EPKVAAWVNIRNCGKATAIYNP---------------------------------- -----RNHSPFTDMI---LYLINRFV---------------------------------- ------------------------------------------------------------ ---------------------TNYS--------------ELYGYSYINRVKNFF--GESI ---------------------ENYS--------------KMYGYGYIEKANEFL---KYG ---------------------NHYS--------------QMFGFEYIESVKLFF---EKF ---------------------SNYH--------------RYYGYCYTDRVENFF---DNC ---------------------NHYS--------------QMFGFEYIEAVKLFF---ESF ---------------------NHYS--------------QMFGFEYIEAVKLFF---ERF ------------------------------------------------------------ ---------------------NHYS--------------QMFGFEYIEAVRLFF---KNF ---------------------EHYT--------------KLFGHSYVDSVNDFI----KN ---------------------DHYA--------------QMYGHKYITHANEFM---KNG ---------------------EHYA--------------QMYGFQYIERAKQFI---NGT ---------------------------------------------YYKILSDFK---SNY ---------------------DSYS--------------ELYGRPYIQSAQNFA---KGL -----------------------YP--------------EREGKRYFEAVEAF------Y ---------------------------------------------YYKILSDFK---NNY ----------------------------------------------AEEEEEL----DGW ---------------------------------------------FSNVKQRFI------ --------------------------------------------DVDQLVRSFV---CDY ----------------------------------------NEGKRYTEAVDAFY---NN- --------------------------------------SNCND-EIVMLIAQFA---DNY ---------------------ENYS--------------NLYGHEYITKVKQFFVIREEF ------------------------------------------------------------ NTVVQKPSWVANYIPGKLSTWDYSNKLRH-LASLKK---------IVNND---------- TSSPTSPQPSSSR--DRSDAIDENVRKSNIMTLHES----------INDT---------- EDNHEET-----------------------LTALDS---------VVNDQ---------- TSNKQTP----------------SVKAENIQRDYYR-------------K--VLSEIFNS GNSSEET-----------------------LTTLDS---------VVNDK---------- ENSSEET-----------------------LTALDS---------VVNDE---------- ------------------------------------------------------------ ENSSGET-----------------------LTTLDS---------VVNDE---------- EAKDG------------------------------------------------------- RNTIPSLGNEPISLTSRPSYLSTL-------------------CSIIDDQ---------- ATVT-----------QGDSRNVTNSSRIPYLAKLNE---------VINEE---------- K--------------LSEVYRELLGQ---------------------------------- ISRPADNGAKELHPSVDVPYSAIINH-------------------IVNDD---------- KSKNNSSSNFKL------------------------------------------------ KLS--------------EVYRELLGQ---------------------------------- YIKIIEQFRTRYYETEGKKYHDQ-------VKEWEK---------------------LQG ----DDEHKDQYP------WYDILSNFKDNYYELEG------------------------ YKN------------HGADYCAQVVRSSKGDQSAGR------------------------ ----------------------------------------------------SINAANFV LEDDGKRY----------------------------------------------MEAVQA QRNSTSDMN------CTENSMNCLDTLTEIVNE--------------------------E ------------------------------------------------------------ YFNELNSIIN-------------------------------------------------- YLQTL------------------------------------------------------- FFNDLEELIENNGFA--------------------------------------------- SFLETLRMTNVELSCG------------GSGEQAIHIANNSI------------------ FFDDLQSL--------------IESNGFA------------------------------- FFNDLQNLIENNGFA--------------------------------------------- ------------------------------------------------------------ FFDDLQSL--------------IESNGFA------------------------------- ------------------------------------------------------------ YFNSLHSLRK-------------------------------------------------- YFNCLHQTA--------------------------------------------------- ------------------------------------------------------------ YFARLTVPSSV------------------------------------------------- ----------------------------ACDL---------------------------- ------------------------------------------------------------ YTN--------------------------------------------------------- --KKYLEQVNNWYNLD-------------------------------------------- ----------------IHSVIE-------------------------------------- HFG--------------------------------------------------------- FYSKV------------------------------------------------------- YINSLQESLMDNT----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQCAGTTAKKDRCRRVGVYCAAHRAQH ------------------------------------------------------------ ---------------------------------YQCNGITTKGVRCIKCPNSYCRHHERQ ------------------------------------------------------------ ---------------------------------KQCKGITSKGIQCINAPDGYCHYHIGQ ---------------------------------YQCNGITTRGVRCIKCPNSYCRHHENQ ---------------------------------HQCNGITVKGQRCITVEHGYCHYHIKQ ---------------------------------YQCNGITTKGLRCMKCPNGYCKYHYSQ ---------------------------------KQCTGVTKKGTRCLKKNGEFCHYHIGQ ---------------------------------MQCKGTTLKGQRCIQTESGYCRYHANQ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PRCTATTVKGEQCNQSTVSSGHYCGVH ---------------------------------------------------------MTT NKTPYIPEDTPEYIYIYTVEKKNRKEITWLVTDNSKMKPSKNRNNRHNKDEILIKIGMTR ---------------------------------------------------------MTR -------------MYEAYLEGDLRKLQTWLYQDNSIIIKEGAKEIWKAPDTILIKIGMTR ---------------------------------------------------------MTT ---------------------------------------------------------MTR ---------------------------------------------------------MTR ---------------------------------------------------------MTT ------------------------------------------------------------ S---AAPVQSDGFIYMYTMGKGGAASLDWLKADRSVLEKKPVLQRWQLDGDILVKIGMTN ---------------------------------------------------------MTT SNNHKPQSNDTGYIYMYTMTNFLFPPKNWSFKVKNLPDASK-KTDWRKSHYILIKIGRTT -PKQPTSRKTPGFIYIYTLVTKRVDHLKWLHMDYSILRNEKTLSKWSAPGQILCKVGMTR CTSPTKQTEKIGYIYVYTTRLLSNNDKNWSLKVRNLPNVSSKRDTWEKSPYMLIKVGMTT ANNHKTQSNDTGYIYMYTMTNFLFPPKHWTFKVKNLPDASK-KTDWRKSHYILIKIGRTT ASASTKPVTDAGYIYIYTMENFITPPKGWNFQVKNIPQTKKRKDKWDRSPYILVKIGMTT KPSNNNNNNNTGYIYMYTMSNFLNPPKNWNFKVKNLPNSSK-RDKWKKSPYILIKIGMTT KFPKVEPSLKPGYIYVYTLAALLSKTQGGGFLKTRNL-STNAKDKWKRSDIMLVKVGMTT SEVPKPDSPTSGYIYIYTMSELLNSRKLWL-QTRNLPNTKPSKHKWGKSPYMLVKVGMTL ------------------------------------------------------------ -----------MYTYKEMSENHNDSKLQWLFIDESKISKGKELENWSNNRNILCKIGMTT GDNKPQIEAKQGYIYVYS-----------LCEGKNKGGRVNANHERLPANLTLVKVGYTT KPMVSTRLLEWQNTCKNPVINLTPDRIEQLYAYDTKTK-KINSISTLLTKLELKK----E RSDVSKRINEWQKQCKRDIILITPEIVRQ-WIVSSTTKPSMSNVIQKLCRLALNNHSNIV RKTVDSRLLEWQNTCKHPIINLTPEKVDKLYQLKMKSKTSLSNLQKKMEKLFIDDKYDSP KTDVKVRFKEWMVSCHHEIIGLTPENMEMLHHIGFKKKDNVNTITHLFKKLSLKKASRAH RKTVDSRLLEWQTTCKHPVINLTPEKVDKLYHLKLKSESSLSSLQKKMEKLFIKDKSHSH RETVDLRLLEWQNTCKHPIINLTPEKVNKLYQLKLKSTNSLSNLQKKMEKLFIKDKNHLP RKTVDSRLSEWQNTCKHPIINLTPEKVDKLYQLKMKCKNTLSSLQKKMEKLFIKDKGNSR RKTVDSRLLEWQNTCKHPVINLTPEKVDKLYQLKLKSGNSLSSLQKKMEKLFIKDENYSH ------------------------------------------------------------ NP-VAARLVQWRQRCTHPLVALTPARVRELQRVHARRKRVLERLQERMRDLSLHR----- KPCVSIRLAEWRGSCKHEIIGLTPKLIKKLYNSTNRDN-EISRLTKFFNKLSISK--KKP KT-PESRIQQWQEKCQHPLTNMGPPNK---HLIRKR-----RGLVERLACMSIDD----- KPTVLARLLEWQNSCKHPIVAVEPSMVEELCKLKLQSSPEDKTLSMLFRKLSLKGKKEIH QT-VQRRLRQWQDKCHHELTCLHPQKK---IESSNK----LDLIIHRFKGLSIKK----- KT-PESRIQQWQEKCQHPLTNVGPPNK---HLIKKR-----RELVERLACMSIGD----- QL-PNIRIKQWEQKCKHELVNLGPRNQ---YLVKVR-----EHWWERFKRLTIRDSGGNV QT-PKTRIKQWQEKCHHDLTNVGPPNKN--LIIKKHRH-DYHDWLKMFMCLTISD----- QT-VSKRISQWESKCNHKIECLYPNS----HKFQS------SSFLQRFERLSLNG----- GT-VARRLAQWQNQCHHDITVLGPATEEI-VELKFKS----AAIASRFN----------- ------------------------------------------------------------ NK-VPIRLNAWERSCKHEVINLTPENIQTLTKLMLQAKPSMKQMISLFTKMKLKDQQQMR KT-PRKRLQEWSKQCQHAIELLPNPK----YPIQRR------------------------ KPQSRQESPLDLLTYKDGGFFIDGTNLNLSEVENRIHRFLWEKYGKGFIYCYGCDPM--G KHTTITSRNKSDRCFTENGFRCKDS----GHVEREIHEWLWKEYGKGNIICEVCQKT--- KPNYAKVESSSFHTYKDGGYFIDGKLMKLSDIESAIHRFLWKKYGKGLVYCYGCDPT--G GKQKVSIRIQDLYTYKNGGFFTDGNKLSLEEIENLIHRILWKKYGKGIIYCSGCNHT--- KPSLPDPKVPTLRTYKDGGFFISGKSMKLPDIESAIHKFLWKKYGKGLVYCYGCDPT--G KPPFLEHKVSKLYTYKDGGYFIDGKSIRLPDIENAIHRFLWKKYGKGLVYCYGCDPS--G ISSFSEHKVSSLCTYKNGGYFIDGKSMKLPDIESAIHRFMWKKYGKGLIYCYGCDPT--G TSSILDRKVPILRTYKDGGFFINGKSMKLPDIESAIHKFLWKRYGKGLVYCYGCDPT--G ------------------------------------------------------------ -PHGADAQEPPLLTFAHDGFRCRGD--ALAAVEQSIHQALWRRYERAYVLCSACTRS-KA GRSQLQQVPLELKNFYDGGFYYRPSKISLSDLEAMTHRILWKRYGQGLLYCYGCSVEHGN ---------PVYSRWKNGGFYCRN----LNLVESTIHQELWKKYGKGQVYCVTCLAEEAK RPSAEH-QLKGLKCFRNGGFYVVDG-SKLEDVEVNIHKLLWRRYGQGFIYCHGCKNEKGQ -------ERGKFRTYDGDGFLCPRG---VNVAESEIHKMLIAKYGSGDVYCTGCKENRNG ---------SAYTRWKNGGFYCRN----LNLVELTIHNELWKKYGKGQVYCPTCVADEAK NTVGDDTSPYTFQRFKNDGFHCKKN---LKQVELKVHSTLREKYGKGDVYCSGCVPDQNN ---------PEYNRWRDDGFYCKNN---LKLVESTIHRELHNKYGKGDVYCIGCLQDGNS -----RHKAPEFATFQDDGFFVPRD---VMRAETEIHHLLKLKFGRGDVYCTGCVAKESD -------SPKPYSTFRNNGFFCGRN---LKSAELEIHRLLRAKYGNGDILCTGCATPRSE ------------------------------------------------------------ IQSPSPPIPPNLITYKDGGFFHDSKTKTLREVEANIHNILWAKYGKALTNCFGCDPN--G ----------NQETYDASGWLIYKEAKSPQAIETQVHNLLWQLFGKGHVVCDGCHKNDNG QKRHTEWFHLPIRDLSSVMRTIDAFCYSG------------------------------- ---HREWVKVPIGQMEYIVNTIDRICSDSFS----------------------------- KKRHTEWFNVPVLELPSVLMIIDSFCRRGEC----------------------------- ---HTEWFKIPIKDLPFVIQTIDSLCLAQKA----------------------------- KKRHTEWFNVPVLELPSVLRLIDSYCLGGES----------------------------- KKRHTEWFNVPVLELPSVLGIIDSFCHEGES----------------------------- KKRHTEWFKVPVLELPSVLRIIDSYCRGEES----------------------------- KKRHTEWFNVPVLELPSVLRIIDSYCFGGES----------------------------- ------------------------------------------------------------ PTRHREWFKVPVRDLGYVLYTIDDLCLGGRA----------------------------- PVRHKEWFMVPVTDLPHVMETIDALCSGF------------------------------- FKIHMEWFLIPKEDIEEVYQLIDTICVKIG------------------------------ PTRHKEWFLVPVSQLPDVFKAIDALCVGK------------------------------- YNIHVEWFLIPKKDLDTVYQLIDMVCSKYYN----------------------------- FKIHMEWFLIPKEDIEKVYHLINTVCMKIG------------------------------ YKVHIEWFLIPKADLQSVYQTIDELCFTIGG----------------------------- YNVHVEWFLIPKRDIDQVYRLIDSICMNIG------------------------------ YNVHVEWFPIPKKQMMDVYRIIDSVCLKYAP----------------------------- YNIHVEWFLVPKSDLEYVYLVINSVCLKNRI----------------------------- ------------------------------------------------------------ NKHHTEWFCVPISELPNVLKTIDSICHRS------------------------------- MNRHVEWFCLDRRDVPVVYEIVGCLTNGGDP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MSAPSLRSTSVLTEHLEYPPVSLVDDI ---------------------------------MTTPTMQSTSLLTEHLGYPPISLVDDI --------------------------------------MRSTSILTEHLGYPPISLVDDI ---------------------------------MAAPSMQSTSVLTEHLEYPPVSLVDDI ---------------------------------MSAPTMRSTSILTEHLGYPPISLVDDI ---------------------------------MAAPTMRSTSILTEHLGYPPISLVDDI ---------------------------------MSAPTMRSTSILTEHLGYPPISLVDDI ---------------------------------MSAPTMRSTSILTEHLGYPPISLVDDI -------------------KRGKSLKERSWLSIMAAPTMKSTSILTEHLQYPAISLVDDI ---------------------------------MAAPTMSATSLLTEHLGYPPISLVDDL ---------------------------------MSAPTMRSTSLLTEHLEYPPISLIDDI -------------------------------MSDKTLDERTTAILTEHLEFAPLTLIDDV ---------------------------------MSAPTMRTTLLLTEHLGYPPISLIDDI ---------------------------------MSATDYRATALLTEHFGFPPLALIDDV ------------------------------------------------------------ -------------------------------MTSTYQDPRITALITEHLGYAPLKVIDEV ------------------------------------------------------------ ---------------------------------MNSSDYRATALLSEHLGFAPLTLIDEV ----------------------------MADVSGSSIDFRVTSLLTEHFGFPPLALVDDV ------------------------------------MDYRVNALVTEHLGFPATVVIDDV ---------------------------------MSAPTMRSTSILTEHLQYPPISLVDDI ---------------------------------MNDSFIRTTSILTEHFGYAPIAVVDDV INAVNETMYKCTSAMEKYLLDR------------SEVDGVS-----------------YE INAVNEIMYKCTNAMEKYLMQR------------NIIGKKD-----------------FS INAVNEIMYKCTAAMEKYLLSK------------SRIGEED-----------------YG INAVNEIMYRCTAAMEKYLMKK------------KIINGRD-----------------YT INAVNEIMYKCTAAMEKYLLSK------------SKIGEED-----------------YG INAVNEIMYKCTAAMEKYLLSK------------SKIGEED-----------------YG INAVNEIMYKCTAAMEKYLLSK------------SRIGEND-----------------YG INAVNEIMYKCTAAMEKYLLSK------------SKIGEED-----------------YG INAVNEVMYKCTAAMEKYLMEK------------SIVGGRD-----------------HS INSVNEIMYKCTQAMETYLRQR------------HQVGGED-----------------FT INAVNEIMYKCTHAMEKYLLER------------NEIDGVD-----------------YT INAVNEIMYKGTTAIETYLKEQ------------KQLMKNG------------IFTKVTE INAVNELMYKCTQAMEKYLLER------------HVLNGKD-----------------YQ INAVNDIMYKCTQAMETYLNERQQKRLE------ETMKEKNSDEDVVMEGPEDTPSAIPD ------------------------------------------------------------ INAMNSITIKGIEAFEKFLLDLHSE---------NKIPQSI-----------------SK ------------------------------------------------------------ INDVNQIMYNCTDALERFLLKRREVQVQAL----QNAKQGSGSNPNPMNGDYVSSSVFPL INAVNEIMYKCTLGVESYLQERKEH---------ALKAGKD---------SSDVFRLVTS INAVNEIMYKCVAAMDTFLSERT-----------DKFGAGD--------------KKIIS INAVNEIMYKCTSAMEKYLLNK------------NFIEGKD-----------------YT INAVNQVLYTVTDAMEDFLKTRQA----------RHLQKIEQTARDASDYQLRVAELPTT E---EIRVGVAKLESLMESAVDRNFDKLELYVLRNVLRVPEELLDAGVFRLKHQV-DLEV D---EIKIGTAKLESLLENSVDKNFDKLELYVLRNILSIPSDLLEENRFRLLHHE-KLVL E---EIKNGVAKLESLLENSVDKNFDKLELYVLRNVLRIPEEFLDANVFRLENQK-DLVI E---EIKIGMAKLETLLEHAVDRNFDKLELYALRNVLRIPQELLDAHVFRLPHQR-DLIV E---EIKSGVAKLESLLENSVDKNFDKLELYVLRNVLRIPEEYLDANVFRLENQK-DLVI E---EIKSGVAKLESLLENSVDKNFDKLELYVLRNVLRIPEEYLDANVFRLESQK-DLVI E---EIKSGVAKLESLLENSVDKNFDKLELYVLRNVLRIPEEYLDANVFRLENQK-DLVI E---EIKSGVAKLESLLENSVDKNFDKLELYVLRNVLRIPEEYLDANVFRLENQK-DLVI E---EIKIGIAKLESILEQSVDKNFDKLELYVLRNVLRIPQXSLDANVFRSAYQR-NLII E---EIKVGTAKLETLLENAVDKNLDKLELYVLRNVLSVPAELVEGGHFRLAHYD-KLVL T---EIKVGTAKLESLLENAVDKNFDKLELYVLRNVLNVPQNLLDSNAFRLKHHS-DLVL D---EIEIGMGKLESLLESTIDKNFDKFELYCLRNIFNIPKDLI--PYIQLSHQQ-GIEF E---EIKVGIAKLETLWENSVDRSFDKLELYILRNVLQIPQELIENGSFRLRHHD-SLSL D---EIQLGTAKLETLLESQVDKNFDKFELYALRNIFTVPSDLVRDGWVRLMHHE-GIEY ------------------------------------------------------------ D---DIYKGTSKLELLLQNNIDVSFDKYELYCLRNIFSIPPDLVQGGWIRLKHLE-NVDF ------------------------------------------------------------ E---EIKSGAAELETLLVSHVDKNFDKFELYTLRNILTIPRDLVEGGWIRLKHHE-GLDL D---EIKIGTAKLETLLESQVDRNFDKFELYTLRNIFTLPHDLVEDGWIKLKHHE-GIEF E---EIQIGTAKLETLLESNVDKNFDKFELYALRNIFTIPQTLVEQGYVRLKHHS-DVAV S---EIKVGIAKLETLLEHSVDKNFDKLELYILRNVLRIPQELLDNNVFRLKHQK-DLVI K---EIEIGTAKMETLLETKVDEKFDLFELDALRNVFNVPSELVEGGWFKLEHHTFDAKS -----------VDPKLQHQVEIELEDKVRELETAFETHAQLKKKVRDLKTVAQRLNRFED -----------TDSATRAHTDTSIEQKLQEIERQYQLNVMLRDRIQNTKELLTEVVQFKK -----------VDDKEIKRSEEELREKVNDVELAFKRNEMLLKRVAKVKKLLVSIRGFKQ -----------TTEKNEQKSEFELHDLMLKIEDEFKRNRELKLQITKTKRLQNQVRSFKI -----------VDENELKKSEEKLREKVNDVELAFKKNEMLLKRVTKVKRLLFTIRGFKQ -----------VNDTEIKRSEEELRGKVNDVELAFKRNEMLSKRVAKVKRLLVIIRGFKQ -----------VDDNELKRSEEELREKVNNVELAFKTNEALLKSVAKVKKLLVTIRGFKQ -----------VDENELKRSEEELREKVNDIELAFRRNEMLSKRVAKVKRLLFMIKGLKK -----------PSQSESELSRLQLEEKAKQVENALRINQELKTRITKAKTIKQRIGKFKE ----------------DTDPAPELRSRLEEIEAAFALHDILLKRVRETRRAHERIVSFKE -----------GDDLQRETQMQELSSTMEKIEEVFKLNQVLQSRLKETRKLQAKVVKFKQ ---------KSDNVEQKREFDQQIKNLQLKIMQELQLRKILKLQLVKVQKLIKVLIAIDN -----------EDSDHEQALAADLEAKMRRLQESVKLHKELRRQTKDVRRVLNRIKQYKL -----------QKDEDSLKLDEEIEKLIKFINMELSLRKILKLQITKANKLVRMLRLFRL ------------------------------------------------------------ T----NVK---NSHIVKWEYDQQIVNIYARIEEELLTRKVIKLQMIKAEKIIENLKYIKK ------------------------------------------------------------ --------GLSLESSDGSNANEVMKQLISNINLELQLRKILLLQKAKATKIIGLLRQCKL -----------TDKASLRKLDEKISSLVNNIRLEAQLRKILKLQIIKARKVIKILRLFRN -------V---SDDSEAAAADERIQNLIKKINQELTVRKIIRVQVVKAKKIIALLRKFQA -----------ANKDQIDDGVKELKDKVSEINKAFQVKYQLQHKLDRTKVLLNKTRKFKE V----------SKVNEDAELDREIARLEHELESLMRQQQRLKLELNRLKRIEATVARCGS LLVRFVK----EQGDD----------------------AEGVLRSLR------------P KVIDLLR----CDDNLTT-------------------ALHELWDDLK------------P KLSDLLK----CKDDE---------------------QLQKILESLK------------P LVLQLLK----CEDSQ---------------------KSQEIFKSLE------------P KLNELLK----CKDDV---------------------QLQKILESLK------------P KLCELLK----CKDDE---------------------QLQKILESLK------------P KLNELLK----CKDDE---------------------QLRTILGSLQ------------P KLNELLK----CKDDK---------------------QLQKVLESLK------------P LVLAAFK----THNDDSP-------------------EFQQIVESLT------------P QVRNLLENGAPSTKEEAE-------------------RLRALLGSLR------------P LMIQLLD----CKLNSEE-------------------STVQMLKSLK------------P DFKKIDF----ASGGGGNE------------------ESIRILKNLQ------------P LVLTTLK----GKDPKNN-------------------EISAILQSLS------------P CLSFLDH----DNNGEKLTA-----------------EARLAIKSLS------------P ------------------------------------------------------------ NLLPLTT----LTNQQWKLSDLVVDKKIDDKQSELSEPLRELYNSLQ------------P ------------------------------------------------------------ CIEKVIS----ANSGTLLPAD----------------VAKILKQHLQ------------P NLGNTDN----TNSSKPQLSP----------------KAREALKSLS------------P CISALEA----GPNNDLLSP-----------------EAKTALKSIS------------P MVITILE----CREDSD--------------------VIKETYNSLK------------P SFSFLTD----RSS-----------------------EASKLYRDVV------------P LDDTLKLLVLQLKRLYIESEENCSMDKVNTVVES--TRQNGYRPN--SSRTKYIDASADM LDVAVKLITTRLKQIYLENEEFYSIDQVNRLVKR--YNELRNTS---IVRNGYIDKKSQH IDDTMTLLSSSLRKLYVDSESTSSTEEVEALLQK--LKANGKHNK--DYRTRYIDIRTNN LDDTMKFLTSQLRQLYIASEENCSREKVNETLRL--AVANGLTNTRPNSRSDYIENGTQV IDDTMTLLTDSLRKLYVDSESTSSTEEVEALLQR--LKTNGKQNNK-DFRTRYIDIRTNN IDDTITLLSNSLRKLYVDSESTSSTEEVEALFQK--LKSNGKRNK--DFRTRYIDLRTNN IDDTVTLLTNSLRKLYVDSESTSSTEEVEALLQR--LKSNGKLNPK-DYRTRYLDSRTNS IDDTMTLLTNSLRKLYVDSESTSSTEEVEALLQR--LKTNGKQNNK-DYRTRYIDLRTNN LDD--------------------------------------------------------- VDETMKLLAVQLRALYTENEAFCSADSVEELLCK--YSALHHSG---ATRSGYIHNSART VDDTIKLLMSQLRGLYLENEEYCSLDQVRAITTR--YEQLKDTT---VSRTGYINRQSE- IDETLYFLISQIKNLINQIEQLSNKVNTN-------LKTQKFIP---NLRDKFIDGRTFR INESVKFLASQVRSIYLDSSDQCSMERVKDLVAR--QQVIESDV---LSRTRYLNNTTDI LDENLYFLLSQVDDLITQVLKMHNKFKNGVSQGG--INDMAFTP---SVRDRYIQGKSFK ------------------------------------------------------------ IEQTLAVLQNELNETIDSVANLSKRLDDDVT-----KQKIVMRP---SSRDKFIENRSRR ------------------------------------------------------------ INENVYYLLNQVDELLLQVLKLNDKFMKDKSLEG--VRDLRFTP---TNRDCYVHDKTVR IDETLYFLLQQVDDLISQTNRLSEKLKLSG------SNQIQFLP---NLRDRYIDSKSME VDQTFHFLITQVDDLIRQAHHLHDLFSGD-------IQSTEFPL---SSRDRYIQMKSSK IDDSMKLLTSQLRQLYIDSEEYASMETVNNII-K--MTLNEKNDELLNSRSDYIDSSVKV LAESVQFLVNSTRGLEPQVRTAKRR--------R--IDRVNLPA---SARDQYLDTVTNQ V-L----EKLLHP------------------TETDT----SHKN---------------- I-L----DELHIS------------------VNSTQ----NNEDS--------------- V-L----RRLGLL------------------DDGET----EGRSV--------------- I-L----ERLNLR------------------DHQDD----SKSSQ--------------- V-L----RKLGLL------------------GDKED----EKQSA--------------- V-L----RKLGLL------------------GDGEK----ENQPT--------------- V-L----RKLGLL------------------DDNKR----ENHSS--------------- V-L----RKLGLL------------------GDKEE----EKQPA--------------- ------------------------------------------------------------ L-L----RQLF--------------------GDAAE----DAAPD--------------- -------QTLGSL------------------FPGEP----STEDV--------------- V-L----QQTGIWKDLEKNDIKISVQG----NDNNN----NNNNN--------------- V-L----TNLLKE------------------NNNNS----SGPDV--------------- L-L----ESIGVL------------------EPDHL----QNSQS--------------- ------------------------------------------------------------ I-M----QRLNLVDGLINTTTTTTTTTTNVAGAGAGAGAGNGEKS--------------- ------------------------------------------------------------ I-L----EQIGIL------------------GPDAG----HNSSA--------------- I-L----Q---------------------------------------------------- L-L----ERVGLP-------------------SSPG----DTARA--------------- M-L----QEN--V------------------DKQKS----LSVPI--------------- A-I----LKAGLWSGLDDEQVSLAAEFAKRDEGQQE----EQQGTQEEHQQENNPQQENV ------------------------------------------------------------ -----------------------------TNTSIRSLQEDDPEIE--------------- -----------------------EPS-----IGVQGKETDKLDIE--------------- -----------------------DSS-----ANAIPNE---LIIE--------------- -----------------------KPD-----ARTQAGDIVSIDIE--------------- -----------------------ESG-----KKEQEEEIARLDIE--------------- -----------------------ELG-----VTKQEREITNLNIE--------------- -----------------------EPD-----VRKQERGIANLVIE--------------- ------------------------------------------------------------ -------------------------------HELSLADPEGGTID--------------- -----------------------DMN-----APVSTEEFTQPQIS--------------- -----------------------NNNTLTDLQNQDDIDMIIPEQD--------------- -----------------------NTD---TSSLSQTLESATPLIK--------------- -----------------DILHITDFTSGSDIDNVKQINETLQSVR--------------- ------------------------------------------------------------ ---------YGSGSGSRHGIDANTTGSTAKRLVLQNDVGLDMDIDSDIIMEEETTTGGVA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KIDNAISSTDLDIVNAIRESIE--------------- -----------------------ELEELELKVNDIPKE---LDIE--------------- ASREAQQPTTSLPSLSPPPDPPSELDPDEDKENKAPRNTNTQTVSMEDLAQPEPMAEPDG --------------------------------------TTPVIEILD------------- --HPDWSSMQKVI-------------------------EVNIIDINDEQSLVGNEGTANG --EPRLDLLDDVL-------------------------MRQVIEFIEDASIQILDGSSNV --DPQLSLLS----------------------------MNEVIELIQEGDLQIIEESCNT --EPQLDLLDDVL-------------------------MSQIVDFVEDASIQIIDGPSNV --EPQLDLLDNVL-------------------------MSRSDGFIEDASIQILGGSSNV --DPQLDLLDELL-------------------------MSPLIEFIDDTSIQIIDGPSNI --EPQLDLLDDVL-------------------------MSRLVDFIEDASIQILDGPSNV ------------------------------------------------------------ --HPNWDALQKHV-------------------------SIELIDIES-IASDRAGITRED --HPDWSSIQKFT-------------------------DIEVIEIEDKANRNVIEISSEI --DIDVDAIKNINAQI----------------------PTPLIELSD------------- --DPDWTSLKNST-------------------------SLEIIECNDEQLRNERPQSSNV --LPEPQPQPSSG-------------------------SIEIIDVLE----SPTVTKSNG ------------------------------------------------------------ KESSDGKALANLRDIAKAM-------------------YEKLNLVEQNNKLRQSHNNSQH --------------------------------------MTMMMT---------------- --TVLYSAYAHT------------------------------------------------ ------------------------------------------------------------ -K---------------------------------------------------------- --DPDLSVLE----------------------------DSSLILIED---------SDDI EVEPETDLLGSEVALSSDPLISSDSLVHSETEMELFEV---------------------- ----------------SSLLDDSLIEEIISDNNDNVIHPTEIDESIEISIP-------YV VVVLISSEGEREGPPAIHYSLARSLSDSVGQRNVEDDDVVLLENSVSVSFS-------LE EVIALSESVDQDELKRAYDEH--AIPSSPESKPLGLNDIEIIEQNKSI---ELSAPFYQD SVVIDLAMEESD----QQETPKKRYPSSP----VIHPDILVIDEIKTRENDELSVPFCDI EIIALSESMDQDECKRAHVSSAEMIPSSPQRKSVS-NDVENVDLNKSI---ELSAPFFQD EVIALSESVDQDECKRTHDCQANMMPSSPQRKPCGLSDIEIIEPNKSL---ELCAPFYHD EIIALSESIDQNECKMSRETSADVMPSSPQRRSCVSDDLQIIEPNKSI---ELSAPFFQD EIIALSESIDQDECEKLYESSADMIPSSPQGRSRVSNNVEIIDLNKSI---ELSAPFFQD ------------------------------------------------------------ GVIELLSEADEALGRR--YPSSPTIRSTEANIDESIGNRQLWLQSIELNGEEEVEETISD GLDNSMNRLDKSRV--YSSSPGAITRSKTCDKPFFENKRIGQEKSIEISASFSNWNSSKL ----------------DEDEIDFNVNITRKPISLTTNEPEVIELLSDS---TEDPPILTS DIIELTSGVEDATPARSMYPSSPRLCQVSSPIKKRTNSVDILDQSAELSAVLQSSPVLHE EIIEVLSDSDDA----NIHPHVNETRNKLIDKGLILSDISYDDPSQKSDNA-------EK ------------------------------------------------------------ SMLQQLSSPPMSSSPMQHNQHNQHAHHGIHSSSVYNHNGTIVSGARKENWNKERTQLLSS ----------------------------------------------------------SK ----------------MDLTLTNSLSEESNDNSVATKAADDNGYARRTYG--------KQ ------------------------------------------------------------ ------------------------------------------------------------ RIIEEDQRIRKAH---NNNEPVQLIITSSSQSSNKTKINQDCHNSEDIKINEVIAPF-IE ------------------------------------------------------------ NDKTAESNSTSLGNSQKESSLIVTQTA----SQRKRILDEILSDDLSISTD--------- VEGRFQNDTAIESDNEPASQPQTQTFKRSQSENSGLSISALSDDEEASPLVSNQRSVIHK ISTSKLDDFSATTNCIMDSSLKDDDRSG---EKTKRLLDDLINDEWSADVESSEKKQSKH SANSKVSNVISSHHSMSYIHDIDTHMPNEKFSKNKRLLDDLISDDLSPFTDIASGNSSNK ISISKLDDFSTTVNSIIDSSLRNENNAK---GNAKKLLDDLISDEWSADLESSGKKHNKS ISTSKLDDYLVTANCIVDSSLSNENNAK---GNAKTLLEDLINDEWSADVESSGKKQNEQ ISASKLDDYSATANFIAESSSRNENNSG---GNAKRLLDDLINDEWSADIESSGKKQKKH ISTGKLDDYSTTVNSSTASTLRNGNDAI---GNAKKLLDDLISDEWSADIESSGKKQNEH ------------------------------------------------------------ ACSAPDVSIQELLQTFTPPKPHAGRVMKAGALQTKDVLQDILDDNLSSWD-TPSTSGIRS EENEPVDPISLEPVNSNKSDIQNSKSQR---CLKENWLNEIVSDVPSSPEASGNSFKSRT IQSSQTKDFRSSPNPKPNQTFISTNNQTSISYTSTEQITDVESDEEETSI---------- ATPIPINDSSVDSVFLTHVTQKSSSPEKMASKRFKSSLDFLVSDEVSSSDIPDANPALRT IVKRRKRNIIILEQPSSPDRLANTS----------------ILDSSFSFV---------- -----------------------------------------MNDSIIDSS---------- SSSSSSSSSAPPSPSPLIEKQLINPIGSASLTDVENSLDESIESQGSIDKASDGERDRAH TVSLKQTSTTSVTNNFAKSSFKAATRTSSFLEEEIVVLDSDGEDSIETRDT----TDIKN DERRHSESLFEVGRTSSQIDVSSQSGAK---TQVSTSRNILDLNNWISSS---------- ---KRNRSIILLSSPPSTGQLFVTE-------------DETIEESSFSFL---------- ------------------------------------------------------------ DDLSELDSISSALDYSGITDESPKTVVKRNLFVMDTSLDDDPTNNSSSGIDISTRQATKK ------------------------------------------------------------ DFS-----------------LDAIPKQTSGRTRDSQKN----DSALYESSQEKASIASSP NIESEVKSGKYIIPLPQSSKMSQVFNYQLASSPTPNKSPSSRSTLPVKSPLQLSTTVANK QFNLKNVAEKWGVQPCKNSRQIPIAQTNNGEIESQKSQ-VEAANILFDFPLSPVNYDSPS KTNLKDLSSKWGIGLEKLPFEIIDDRAIQELKLSKTKGVQSSQNVLSDFPLS-----SPT QYNLRDIAEKWGVQSLKNPKTQGIGKTNSDISDSPKSQ-IGAADILFDFPLSPVKHENPT KFNLRNIAEKWGVQSPKKSEKEMIMETKYGTADSQKSQ-VGAADILFDFPLSPVKNEDSV QYNLKSIAKKWAVPSSNNLKEQEVVKPNNGATDNEKSL-IGTANILFDFPLSPVKYENSA QYNLKNIAEKWGVQSFKNPKAKKIEETNNDINGSPKSQ-VGAADILFDFPLSPVKYEDPT ------------------------------------------------------------ PETVATLAAKWANKTEKTSPRSSGNRGNILLKRTLANRNNILSSELGGESSPSLQALTTP PNKVAALAAKWSNIVVEPVGGRPTISRDSANNSSPFND--TPNNHSMGSPFSISPMVSPP ---VQKISGTSKIVASTRLPSSPVSIANQEPEKTMNDSIVDSFSFSMDNLVTTIRNGGPK ISSITAMGAKWSQIGRYT-GSPPACQQESKENKRSAKRPEENSGAEAENERDIKRARRLF --------------------TRENEPEPTNTAASSNTAILDVTNWLSDSGDESNLILRHA ------------------------------------------FSFLMDNVVTTIRNGGSR HNNIADLPHTKNVAASRALDNSILPASSPIHTRVVSTNFGQDSDSILDSSFSFLNSNPMA LFN---LVNEFV--------SKPISSSPVKLPSESNNSILNDSIVDSTFNFSIDGIIPP- --------------------DDDSFTRDLIKDVTPKRQGRGQ-----KSMMKNVLNSSPV -------------------QQNQKQRQDQNINKEPNTSILDVVHWLSDSSMISESDPKSA ------------------------------------------------------------ S--LQSLANRWGIKCDRVSKANQVQGSPRKNSSPKKKQKLFSSQQLNENATSSQASRNIF ------------------------------------------------------------ NRIK----------KSSSERHKKSQSIDSKDICIKSPTRKIN-------------LGVTE RSREVQPPKFDPYLTRKLKKPQNKATADVSSVALDLTKYMEDDLYGTLVSDTHIRQQRSL KEKPSSIANHASSSDHNPGALTKGNQDEVLKVAQNSIYQKDEGQLRYIPKKKKRTIALSR ARKNSSLVSRSQEALKPLDTDVSVENNPNEAAPSVKIRRELELELSRARREKNNKASLET EEKHNSIANENSSPDNSLKPAGKQNHGEDGTSMAKRVYNKGEDEQEHLPKGKKRTIALSR KEKHGSITNHDFSPGRSVEAPANQKHDEVLEVVKKRSHEQIEDDSRHLPKGKKRTIALSR EGKHASLVNHNSSPERNRETLVEQNHDEFLKVVEKRVHNKGEDDSEHLPREKKRTIALSK EKKHTSVANHNSSLDDSLAPVAKRSYDEVLKVVTKGTHEEAEDEQGHLPNKKKRTIALSR ------------------------------------------------------------ LPAKSNDGDKNQTTNVMTTGGFRLGTMEKQTLNGSACVDRIQ-----QVPVSSPESVSFL RKSRTIANKRPILFPESSLNALQPQILAQSEDILDTSSEKPNEKLSFTVCDKGKKKASQL LSSKSQPVSAGSGLSSGPNPVSSSFKMPPFVKWLSSDDDDDD------------------ VESSLTEADNSTRYEQPLRDDGEVGSVAPKYLGLDSDLQKST-------PNKSRRLSLPI TDKTTNALKSNTTSNRDTTRKINSSKVPSYTKKTSVATGHVT------------------ LKSKSQPVTTGLGPSSVSNSVSSSFKMPPFVKWLSSDDDDDD------------------ NPTRVQKIDSDVNYSNIENDDGNHNDGSNNDDNNKNNNDDDDEFGNLIRTNFSKPISDPL --KKAAPPPPPPPSRAPAPRQSNSTDIPANILWLDSDEDEDD------------------ IERYSQPLESIPESYSPVRPKETTRFGNELINKNPVARIEFS------------------ SPRAVDSHKNKTTSDTTISSKPVVTEISPPRSKTKTNEYSLS------------------ ------------------------------------------------------------ NQCPLSSPVSNSLIESSIRDGNNQDTHQTKDTNINEENVKSN-------SIIELSNESKN ------------------------------------------------------------ SMQTDVLFEDNNFNNIECTQETDLSFSTATADTP------TVGFKEITFKHKESTNEGLN DTKTNSYHSESNYEHDSIVIESDED--DDITNTRQEKPLFVQHSSQSTPVSSN-KLALRQ TQAGNIKSPDTVELNLSKFLDDSDSCSVDILSTPTKKLNILRTCSQPILGNSDRSQEAKR SELMNKDAPDIIELNLSKFLDEDDSTDLNLRSTPIKATRTASQPNPRLNKHVSVVLPIQR TLINSTKLPDTVELNLSKFLDSSDSITTDVLSTPAKGSNIVRTGSQPIFSNANCFQEAKR TLIKSTKSPDTVELNLSKFLDDSDSITMDILSTPSKKANIVRTGSQPILGTSNPPQAIRR TLMKSTKAPDTVELNLSRFLDYSDSISDNALSTPIKESNVVRTGSQPVFQNANHFQEARR TLINSIKPPDTVELNLSRFLDSSDSITTDVLSTPSKDANIVRTGSQPIFGHPNRCQEARR ------------------------------------------------------------ EGLSDIPISKPVQLTQRCIAATNTGYTDNCASTPDTDTSILSTAGEALPHYPVKPSKVSR ELIKVSKKPSMRGRNIKVSRAFKENENTQCKSRVNVSKSVSDTEDNRLHGHLDFPSSRDN ------------EKEEDPIVPTSQPVPETNFDAQ---------PAKRSRTMQEPPQSAPK GSQDDNLVRNKLWDMRTRRLKTSNNETTSSIEVTERRSGLAVSPPERLTTKASDTGSGNE ----------AVDLRIAELSD------PIESSSP------LQSSSKKFAQSHRKVVQPAK ------------DDELDPIVPTSQPVAETVLSAQ---------PAKRSRTVQEPPQQAVK RIFKNDTSNASTLKTGSSTLSSSHPLPKVVSMAPRAARAFASRSSASFRSASEPERSKRQ ----------------GPIIPSSQPAPAPVVAQP----------VKRSKSTQEPSTSVPA ---------------------------DPISSSP------IPSSFPKSVSQPTELSSGPG ----------------FQLKNTSVSPTGTNLEPK----------SKKVEGSPS------- ------------------------------------------------------------ SFMGEDLADSIIEATLTSILEDNEK--LPVLSTP--------SKSKRCYNAIQNESFNNE ------------------------------------------------------------ SHN--------FSDSIFERQRLKQYITNIRDITETESQELYNKLIHTEKG--LFNAVNQT PRH----------VEDEKIDKVKPMV-NARPFTDQEYSEMVKKCLGTSEMRKLYNECNKV SKTLATGNVRSAKSTAREISQLENYIIYGQYYSREESRSKIRHLLTENKN--AFKQVNQI SKTASEFNSDLFLHDNNYQDNLKAYIVNGKEFTHDESETMVRHWLKENKE--AFKQVNQI SKTLTAEDPKCTKNTAREVSQLENYIAYGQYYTREDSKNKIRHLLKENKN--AFKRVNQI LNTLANEDVQRTRSTAREISQLESYITYGQYYSREESRSKIRHLLKEKKG--AFRQVNQI TRTSANDDNKGTQNTAREVSQLESYIVYGQYFSREESKHKIRHLSKENKN--AFKRVNQI SKTFTAEDSQCTKNTAREVSQLESYIAYGQYYTREESRNKIRHLLKENKN--AFKRVNQI ------------------------------------------------------------ ERS------------------KRDYIVHSKAFTAEESKAKIRQLMSNTALKKQFNEVNKV ERLGAINDDSLKYSIDSTRLHMRNFVTHGKHYSEQESETTIKRLLQNPVTKKMYNEVNKV LVK---------------------------RSKTVDQVIDLPRIDNFQYTSKDLKEANRA RLI-----TKGSDNVSGTVDSLKNFIVFGKCFTPEESKKEISRSLSTAVGKKRFNAVNKL KRC--------------------------KDPHPAEPYSKK-----------ELNEANKV PVK---------------------------RSKTVDQVIDLPRIDNFQYTSKELKEVNRA ERPSTRDTPKLVQRSKTDVDVIPSFINKAKRAKTDSYISDLPKINNFLYSAKELQEVNKV KRT--------------------------KRPKTTDPVTHLPRIDDFQYTHKDLNEANRA SKR---------------------------RKTPSHNSKDGPSIK-------EWREANKV ------------------------------KSKSRKANVKVPAVLK------EMKDANRV ------------------------------------------------------------ KIRMPESFQNRVDSNNNDHCHLHGYIVRGSSYTRIESEQLIKRFLTEEKE--AFKRVNQT ------------------------------------------------------------ PRDNFKAREDIIVDFSPSLLSFLDKQTEILKSILAPATIQSIHDELPRIRFFRKCHSFYD SRTEETIYNEMILTVNNKVMELIHSKHISFEEELKPLTIIQNYEEFPIIRFKRKCRSIYD YRDNVKARSQIIIELSPNLFQLFQKIESNLQQQVAPAIIQSYDDSIPLIRFLRKCDSIYD YRDNQKARSQIIIEMTKELLSSFIKTQDDFETLLEPATIQSYDDSVPLIRFLRRCDSVYD YRDNIKARSQMIIEFSPSLLQLFKKGDSDLQQQLAPAVVQSYNDSMPLLRFLRKCDSIYD YRDNEKARSQIILEFSPSILQLFQKVEGNLQQQVAPAVIQSYDDSIPLLRFLRKCDSIYD YRDNVKARSEVIIEFSPSLFKLFQKVEGNLQQQIAPAVIQSYDDSIPLLRFLRKCDSIYD YRDNIKARSQIIVEFSPSLLQLFQKGMSDLQQQLAPAVVQSYNDSMPLLRFLRKCDSIYD ------------------------------------------------------------ TREKQSLLAEIVLSINEQVHQYLLEQKVPIAEVLGPTTVIHNFESVPIIRFKRKCTSMYD TRDPDSLRSEITLDISHNVYSGFKEQGIELEKELGPTLIKKNYESLPIINFKRKTASIYD TRKKEELLAEMELHMAESVYSRLE----YLVKDFQSRVI-KASYTLPVIFWKRNINAAYD AKDSAALREEIVLDMDESLYEAFKDEKIDLRERLHPTQILHTHTRKQLVKVRRNCQSIYD TRKKEDLLSEMVIQIPSLLYDRDF-EDEYMKQIFIEPKVEKTNSNLPIISWKRKVKARYD TRKKEELLAEMELHISESVYTRLE----DLVKDFQLRVI-KASYTLPVIFWKRNINAVYD NRKKEELHAEMEIHIGSKPFELLN----EYKEEFNLSIFQDLDSNLLIIFWKRRVRAEYI TRKKEEIFEEMELHMSSGVYEFFS----ETKEDFKSKIF-DGRYDLPLVLWKRNVKAMYD TRKKEDILQEMVIEIALKLKDKIE--SEYFKEVFTLPTVRTTYFELPMVSWKRRIKARYD TRSKEELLSEMIIMMAPCVKSMFK--QDYLETQFEKPHISDFISDLPMICWNRKVKALYN ----------MVVEISNSVSSKFF-ENEDIETEFAESEVRAVSDTYPTIAWKRKVQASYD YRDNEKARSEIILEIPCSILEEFESVCPNLRSLVAPATLQGDSGNIPLIRFLRKSDSVYD ------------------------------------------------------------ LQHDFFFPSNYKIVEENTTILYFDSKEFFVKYKEDK-----RSLFEKLKEIERDNYEIIL QTHGVFYPCDEVIANESICVLVYEALPFFHRYRTDK-----RGLWDEIRQFSKNGMKVIV FSNDFYYPCDAKIVEENVSILYYDAQDFFEQYTSQK-----KELYRKIRFFSKKGKHVIL FSHDYYYPCAPKIIEENICLLYFDAQDFFQRYTNDK-----KELYKMTRSFSKRNKYVIL FSNDFYYPCDPKIVEENVLILYYDAQEFFEQYTSQK-----KELYRKIRFFSKNGKHVIL FNNDFYYPCDPKIVEENISILYYDAQEFFEQYTSQK-----KKLYKKIRCFSKNGKHVIL FNNDFYYPCNHKIVEENVLILYYDAQEFFEQYTSQK-----KDLYGKIRFFSKNGKHVVL FNNDFYYPCDPKIVEENISILYYDAQEFFEEYTSQK-----KKLYRKIRFFSKNGKHVIL ------------------------------------------------------------ LNNDIYYPCETTMCNEPICLLFYNAVDFFTKYKNQK-----QRLYSEVQDLKRAGNKVII YKHDIFYPCEETIVEEPVCILFYQALDFFHLCRTTK-----SVLFHEIRMLTKNGRKVIL KERDIFIPCHPRRVLEKTFVLYYHASVFFEKLRNHTLKVDVSAAKQQALAITPNEYNVIL YTHGVFYPVKETLVNETISIFYYDALQFFHEYATKR-----SQLLHEIRSFREKNQCVLI AERDVFIPCEPTEINEKNIVIYYKAKDFVNSLIEGTISLLLDECKTEAKRHNSSGSHIII KERDIFIPCHPRRVLEKTFVLYYHASVFFEKLRSSTLKADVSAAKQQALSMTPNEYNVII LEKDFFIPCLPKKVTQRTFVIYLLAHDFITKLQNKTLQSDLTKARDFILAKCKKGYHVIL KERDLFIPCHPRKLLEKTFVMYYLAPDFLMKLKKGELKSDVAAALNHALAITPNEYHIII RDKDIFVPCEPTEVSERVVVIFYETEDLINAIREETLESDVKRIRQRVTMEDTLNYHLLV PETDLFVPCEETELQEKNIVLYYEAQEFFEKVHERTLKYQVNRALSLRKQDNTIMYKIII PQRDLFIPCELTEYRERILVVYYDAKEIVKHIQDRSLDTIIRRVIARAQTENSVEFHVII FNNDIYYPDQFKILDEKVYILYYDAFNFFKQYRENK-----RKLFKDIRFYIKSKKYIIL ------------------------------------------------------------ VLYDLAKFKRELEKIEETKYRSRVQSQIYDSQ-QSIQQNKVTTPQSDYGLKKFDVEQRLR VMYGLNALRKKLCNMENRQHEDRVLEQLSGSASKTRRRSTQETKMRELNIKSKNLDRIIN VLSDLNKLKRAIFQLEDKRYKARVEQRLSGTEETLRPQSKKSSQVGELGIKKFDLEQRLR VLSELNKLKKAIDNLEDKRYKERVNERLSGSPTQSKKAQTKMDEIRNLNMNKDDLEKRIR ILSDINKLKRAIFQLENEKYKARVEQRLSGTEEALRPRSKKSSQVGKLGIKKFDLEQRLR VLSDLNKLKRAIFQFENEKYKARVEQRLSGNEEAPRPRSKKSSQVGELGIKKFDLEQRLR VLSDLNKLKRAIFQIENENYKARVQQRLSGSEETSRPKSKKSSQVGELGIKKFDLEQRLR ILSDLNKLKRAIFQLENEKYKARVEQRLSGTEEALRPRSKKSSQVGKLGIKKFDLEQRLR ------------------------------------------------------------ ILNEYSRLEKSLAELENRCMRSRVEQQLTGDK-SPRRKTVKEVQLTALEMNSKDLGRKVN VLNGYDSLEKSLNNLENKEYRIRVQEEMGDTAKKSKKKTNLEQKLEGLKLLAKDLDCKID VVEGYDILLNKIKAYEQRLFKNQVLQGLNVEE---QRRRRKDDTEMSKYPSSSEIEHLVN VLGGRDSLARALQNNENKRFRQQITQDLSGSNVRSQSKGKHSQILEELNISAHDIEKEID IVEGYVQFLTKIRNMEDKRYKKAVLDKLNPND-GDTGNKRLKKQEDGVSLSPKEIDQLVN VVEGYDIILNKIKAYEQRLFKNQVLQGLNVEE---QRRRRKDDTEMSKYPSSSEVEHLVN MVEGYDQLVGKIKAHRQRLFKSQVLLSSGGTGKNSPSKKRKADETLASYPDPIDIEKMLN MVEGYDQQVNKIKAYEQRKFKKQVLHGLNTQE---QARTRTADLEMAEYPSSADIEILIN MVGGYREYLRKLQAAEHRMYKEQMLEKMSDVS-------KGKKATTKPNITASEVQRLVM MVEGYDVFINKLKRMEQNKYKSKVLDRLNEPDSQSQPKRRKNTIEPTLDITAKEAELLMN LVDGYDQYLAKIRNEENKRYKARVLGQPSLGT--------LNHQLGEKELTVKDVESMVQ VLYGLSQLKRDLDNLENNKYKARVNEHLSKSPSNQSNQSKKTEKLQNLNMRSNDIEQRLR ------------------------------------------------------------ YINREWGLKIHIVNSHNDFVHSLPNLCSIIGKQRMDPAIRYMRYAHL-NVKSASDRKDTL EVTIYANVDVFPIENLNEFSHWMKNLVWVVGKMRYDVSVKYKEWSHL-NVKSGKSPTDVL FIDREWNVKIHTANSHMEFINSLPNLVSLVGKQRMDPAIRYMKYAHL-NVKSAQDGTDTL FIDREWKVKIHTVNSYTEFIHSLPNLVSIIGKQRMDPAIRFMKYAHL-NVKSGQDKKDIL FIDREWHVKIHTVNSHMEFINSLPNLVSLIGKQRMDPAIRYMKYAHL-NVKSAQDSTETL FIDREWNVKIHTVNSHMEFINSLPNLVSLIGKQRMDPAIRYMKYAHL-NVKSANDRTEIL FIDREWHVKIHTVNSHMEFVNSLPNLVSLIGKQRMDPAIRYMKYAHL-NVKSAQDSTETL FIDREWHVKVHTVNSHMEFINSLPNLVSLIGKQRMDPAIRYMKYAHL-NVKSAQDSTETL ------------------------------------------------------------ EMIIKCDIDIFPINSAASFANWISNLVWVVAKMRYDPMMKNVNWSHI-NVKIGKTPTEVL EMIVQTGVHVFPISTHSEFITWARNLILVVSRVRYDPLMKNIEWSHI-NVKSGQDGKDVL KAQIDLKANIFMVRAKQESIMWLNSFTHMIGQSLYDKFERNQGLANLGNVKSGADTKSTF KIVVSTGTHFFIAESKEDFVTWISSLILVIARKRYDPLIRHQKWSHI-NLRSAQDSQDAL ESQVRLSVNIFPVKNNKDAINWLQSFTYTIAYALYDKFERNISLANLGTVKSGTDTKSTY RAQIDLKANIFMVRAKQESIMWLNSFTYMISQSLYDKFERNQGLANLGTVKSGADTKSTF QFQLDWQVNIFAVRSREESVNWLNVFTYTIASSLYDKYERNEQLANLGNVRSGSDAKTTF KAQIELGTNIFTVRGRSESVMWLNTFTNMIGHSLYDKFERNTSVANLGTVRSGADAKATF ETEVHMRINMFFPKSMEETVDWLHSFTYTIGASLYDKHERNSEFANLGSVKSGSDQKSTF SVQIELKVNIFTVRNSSEAVDWLLSYTYAISYSLYDKFERNSSLANIGVVRSGSDSKSTF ETQIRLEVNIFPVRNGKEALTWLNSFTYTIAGRIYDKYER-TSLGTLGTVRSGTGSRSTF LIDRLWNVKIHTVNSHIDFLNSLPNLVSLIAKQRNDPTIRFMRYAHL-NVRSSKDRVDAL ------------------------------------------------------------ KKTINEIGKVPDIKASAISDIYSSFQSLLHDFE-AGSLKASSDGNYLMSEALEKRLHKIF YSFLQQVAHVNEPKAKRVVTHYKSFQSMMNDMK-AGYVAQSHDNKPLMPKSLERALHTLY RKTLHQIGRMPELKANNAVGLYPSFQSLFEDMQ-KGRLQSDNEGKYLMTEAIERRLYKLF KKVFREIGKIPDLKANSILQAYPTFQTLLEDFE-NGQLKSGFDGRHLMTEMMEKKLHKLF KKTFHQIGRMPEMKANNVVSLYPSFQSLLEDIE-KGRLQSDNEGKYLMTEAVEKRLYKLF KKTFHQIGRMPELKANNAVSLYPSFQLLYEDIQ-KGRLQSDNEGKYLMTEAIERRLYKLF KKTFHQIGRMSELKAKNAVSLYPSFQSLFEDMQ-KGRLQSDNEGKYLMTEAVERRLYKLF KKTFHQIGRMPEMKANNVVSIYPSFQSLFEDIQ-KGRLQSDNEGKYLMTETVEKRLYKLF ------------------------------------------------------------ SKTLQQINGVTEIRAGRVTSTYPSFQQIFTDFE-KGYLVAGKDGNPLMTKVAEKAMNALL SKTLEQLNLMTRAKAQRVVNVYPSFQKIFDDVS-KGYLTSGNDGKPLMSETIEKAMTTLL SQSMKQFNLMTQAKADILYVSHQSLHSMYTKLRSHGTLGKDNLKRNIVPPSVDSSMKKFF SKTLEQLQNMTKLKAQRVVGVYQNFQRLYEDVS-KGYLTSGSDGNTLMGKGAETAMATLL FQTVKQFRLMTEPKIEKLYGFYTSIFALYSRFQTNDTLGKDNFGKNIVPPSTESAMKKLF LQSMKQFNLMTQAKADILYVLHQSLHLMYTKFRSQGTLGKDNLRRNIVPPSVDSSMNKFF LQSMQQFTRMTQSKAEILYLSHKSMHLVYSKLKAEATLGKDAIGNNIVPPTVDNAMFNFF MQSMQQFKLMTQSKADILYTSHQSIYSIYCAFRDKGTLGRDRLGRNIVPPTVDKSMMRLF IEMIKKFNLMTNQKAEKLYEFYTSVGAIYNRLSQHEDLGK-VSGKSIVPPTVNAAMKKLF IGGVRQFKLLTEAKAERLYSHYPSLQSIYQVLTRSGALERDGNGKNLIPPSAESAMLRFF VQSMRQFRFMTEPKAERLLEHYPSLSRICEQLNNHGTL-----GHRILT---EKTSFRLS KKVLNQIGRMPELKAESITREYKGFQTLLDDFK-KGELKSGPDGRHLMSEAMENRLYKLF ------------------------------------------------------------ TSTDPNEAVD-------------------------------------------------- TSDDPNELIF-------------------------------------------------- TSTDPNDAIE-------------------------------------------------- TCKNPNEAL--------------------------------------------------- TCTDPNDTIE-------------------------------------------------- TSTDPNDAIE-------------------------------------------------- TSTDPNDAIE-------------------------------------------------- TSTDPNDAIE-------------------------------------------------- ------------------------------------------------------------ MSEDPEEQIY-------------------------------------------------- TSDDPTELIY-------------------------------------------------- TADDPDTVSN-------------------------------------------------- TSENPDELIY-------------------------------------------------- TSEDPNDVVH-------------------------------------------------- TADDPDMVIN-------------------------------------------------- TSDDPDKAIT-------------------------------------------------- TANDPNSVIS-------------------------------------------------- RATDPNEVIV-------------------------------------------------- TSEDPHEAIN-------------------------------------------------- VNAANEGVVH-------------------------------------------------- LCRDPDASIE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MSRYFNLELKR ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MLAIMVRFYQSQSEKSAHNTKKI ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MSYYFKNIKPS-YDDDSDEVSDEQ-----------DLDAILASK ----------------MSFYFKNIKPD-LHSGNEDEEDDI---------------ASIIR ------------------------------------------------------------ ----------------MSYYFKNLKPG-LESESDDEDNLG-----------------AIL ----------------MSYYFKNLKPD-LNSDVEEDDGNL----------------LESI IAKKPERARQSPRRLKMSYYFKNLKPD-LNSDVEEDEENL----------------LGKI ----------------MSYYFKNLKPD-LDSDVGEDEENL----------------LEDI ----------------MSYYFKNLKPD-LNSDAEEDEENL----------------LETI ------------------------------------------------------------ ----------------MSYYFKNLQPG-VDESSSEDELEQ-------------------M ----------------MSYYFKNLKPQ-YNSEDDSELDDV-----------------TQA -----------------MSRGKTIRPS-YYDEEESSQDEL-----------------SHT ----------------MSYYFKNLKPG-YESEGELEDEEL-----------------LKV ------------MAKGTRGKPSVIRPS-YDDDSGSDGELA-------------------N -----------------MSRGKTIRPS-YYDEDESSQDEL-----------------EYT -----------------MPRRDRIKPS-FEDDESFENEFD------------------YR YSDNHQLLISFINSKALQTMAKTIRPS-YYDDDDISSEDD----------------FTYS ------------------MSTHRFKPS-YDESESEDD----------------------- -----------------------MRPS-YNDDGFSDDEFT-----------------NSI -------------------MNRRVRPQ-YDDSDESGVEYE-------------------- ----------------MSYYFKNLKPG-QESDSEEDDLGK-------------------V ---------------MKRDSNRNLVRK-RADDSDSDDYNT-------------------- MRGRAESDDESSEEEDDG------------------------------------------ INDTSDAEGSQSEDE--------------------------------------------- ------------------------------------------------------------ SRGNNNKIDNESSDDE-------------------------------------------- MANKSKREIDEQESSDDE------------------------------------------ LADRNKQEVEQQESSDDD------------------------------------------ MAERNKQKIEDQESSDDE------------------------------------------ MTNRSKREIEEQESSDDE------------------------------------------ ------------------------------------------------------------ LHGKQRADDASSEDDE-------------------------------------------- LAGRENGNYGEESSSEDE------------------------------------------ LSKGRSNIGSQSDDEE-------------------------------------------- LSRRKVEEDDEASSDDE------------------------------------------- VLQARDEPSDGDDDD--------------------------------------------- LNKGRSNIGSESDSDVDE------------------------------------------ YKRGKEQTSLNSDNENSESGSGSEQEEHENEHDVDDE----------------------- SKTNKKSRGDEEDDE--------------------------------------------- YLGSVLDNKDESDDD--------------------------------------------- LTKRDEQDDS-------------------------------------------------- ------SGHDE------------------------------------------------- LARNTQQEDESTDDE--------------------------------------------- FAGLEKDSGPEE------------------------------------------------ ---LSKLSF-----GSLKKAEDQLEEEERGELRKKR---KPQ----------HSKPINDE ---LKTLSF-----GSLKKADEMMDNEEQTSRKSKS---KANGEKKHLNKPKSRELTEKQ ------------------------------------------------------------ ---LKTLSF-----NSLKKADEQMMEEEEREL--AK---KPK----------SRKVVKPS ---LKTLSF-----GSLKKAETVIDEEDFKDT-------KPV----------HKKPITTT ---LKTLSF-----SSLKKAETLMDEEDLKDN-------KPV----------HKKQIATT ---LKTLSF-----GSLKKAESLMDEEDLKVK-------KPV----------YKKAVATT ---LKTLSF-----GSLKKAETLMDGEDSKDT-------KSV----------HDKPIATI ------------------------------------------------------------ ---LSSLTF-----GSLKKAEDALQREEAHEAVHNR---AR-----------AEARPRGS ---LETLSF-----GSLKKADAMLQDEETHEKIKGK---DKTL---------RKKKTNEE ---MSKISF-----GALNRAQSKLNKHNQKHK--TQ----------------EDNYKSSE ---LSKLSF-----DAIKRAEAQLEQETVKETPKVK---RKSGGLSRQQWIKDEVSEEEE ---MDSISF-----GALNAAQRKLDQKASKKKGGKA---QRR----------RSDGDRDN ---MSKISF-----GALNRAQTKLNKNNQKHKPSSW----------------KENINNSS ---MASISF-----GALNRAQARLKQEQLRRS--QR----------------DYESDSDS ---LSSISF-----GALNRAQAKLSKRDSDDDEEEE----------------EEEESADD ---FSSLSF-----GALNSAQKKLREQSETQR-------PPS----------RKSSKNQE ---LESMTF-----GALNSAQNELLGKKKKKKSIQT---ESK----------KRKYSESE ---MEEISF-----GALNSAQKKIKNEDEKKWSRRN----------------NSNNDSDG ---LKTLSF-----GSLKKADAILEDEDSEDSEEEA---DKKMVNER-----KRKQVQEE ---MSSLSF-----GAIRNAQKNLDKENEDDS-------DSD----------SDSGPEEN PEVRHKVYKEEEQEES-----------------------DSESGSDDGAFFEEDERD--- RKLDDGQRRQSGLQEE-----EAQQKSQSIKMFAEESFGEESDSDSDGGFFDEESN---- ------------------------------------------------------------ KSVKQKEYKEESFDEE--------DSSDVDS---------EEDSEEDGGFFEEENANSN- YREESFDEDEDSEDQS----------------------------DEDAGFFEEDSE---- YKEESFDEDESEDKSE-----------------------------EETGFFEEDSG---- YKEESFDEEDDSEDIS----------------------------DQEAGFFEEDSE---- YKEGSFDENNDSEDRS----------------------------DEDPGFFEEDSE---- ------------------------------------------------------------ ARSRQEASDSEDSSDS------------------------------EAGFFEED------ SFKSKKRQHEAVVDEP---------------KMFAEESLDDDTTSDEGTFFEEDSSDNDE EEFFDSGSDSDGPPEE-------------------------------------------- SSKAKSFAEESFDDQD------------------------SESSSEEEGLFEEEIASRPG SDDSDGDSDGSEEEGD-----------------------FFETSDDNDQGYNKGKS---- EEFFDSDSDSDGPPEE-------------------------------------------- DSAPEE------------------------------------------------------ GFFEDSDSDGPPEESS-------------------------------------------- SDDSDSDSDDQFFEDK-------------------------------------------- SEEDSEDSEEESDSDS-----------------------------------DAPPQENSS EEGDFFESDSDGPPEE-------------------------------------------- LKVSKKRYVEEEFEDD--------SSDSDS----------DSGSDNEGGFFEEDSGDE-- SGGYERSSYKGNNKGK-------------------------------------------- ---NHSRPKNK-NSKKRKHAPTEHSSKKRVSKIRDIPGLEIAR------QAKSGIYQDVR ---DEANQNGKKKKGKRKHAPTESSSKKKVRSMRKIPGLEDNK--------SKSIYQDVR ------------------------------------------------------------ ---KRRSNKMGSKKKRSKHAPTEQSSKKRVSKIRKIPGLETPK------TQNSNLYQDIR ---DETHHGQKVPKKKSKHAPVEQSSKKRVPRVRNIPGLEIPR------NKRSNLYQDIR ---DENNYNQKASKKRSKHAPTEQSSKKRASRVRDIPGLEIPR------NKRSNLYQDIR ---DGSHHGQKVSKKKRKHAPVEQSSKKRAPRVRNIPGLEIPR------NRRSNLYQDIR ---DESRHGQKVSKKKSKHAPVEQSSKKRVPRVRNIPGLEIPR------NKRSNLYQDIR ------------------------------------------------------------ ---DRRRASGA---RRHKHAPSEQSAKRPVSKVRQIPGLESAR--------REEPQPDIR QMGTSNKNGRR-KKKNSKHAPTEASAKRPVSKIRKIPGIEVPI------SRNSNLYQDIR ---TSSKDTKK---KKNKHAPSESSSKRPVSRIRDIPGLPSRK--------QQTLHTDIR K--VTARSNSEKNKKKKSHAPSEQSSKKRVPRIRKIPGLEIPQ------NMNENLYQDIR ---SGRNPRKQVQKKKSKHAPSESSSKRPVSKVRDIGGLESKS-----------MYRDIR ---TSSKDTKK---KKNKHAPSESSSKRPVSRIRDIPGLPSRK--------QQTLHTDIR ---TSSSSQPT-NKKRSKHAPAVSSTKKPVSRIRDIPGLPSRK--------SQTLHSDIR ---SSNRHGNNDKKKKNKHAPSESSSKRPVSRIRDIPGLPSRR--------EQTLHTDIR ---KSKKTKDK-KSKRSKHAPAEASFKRPVPKIREIPGLKSAK--------DSTLYTDIR RGKTSRFQKNGEKKKRSKHAPAETSSKKPVSRIREIPGLKSSK--------ESTLYTDIR ---SSSKTSDQ--KTRSKHAPAEASAKRPVSRIRQIPGLETKD---------NSKFGDIR ---IGVKSKKK-NKSRHKHAPTEHSSKKRVSKIRKIPGLETSR-------PKSNLYTDIR ---GNNKEDGG-PKKRLKHAPSEASSKKRVSVIRPIPGLTMTKSGADSASRDSKLYRDIR -FTK-----AT-------GE-ATDFSVIRRR-------YKFLDEYREKEIEEMERLL--- -FDK-----AM-------GK-SEDLAKIRQR-------YKFLDEYREKEINELDSML--- ------------------------------------------------------------ -FDK-----ST-------GE-STDLSVIRRR-------YQFLDEYREKEIQELEKML--- -FDK-----ST-------GK-ALDSSIIRKR-------YQFLDEYREKEIDELQKLL--- -FDK-----ST-------GK-AIDTSVIRKR-------YQFLDEYREGEIEELQKLL--- -FDK-----ST-------GK-AVDTSVIRKR-------YQFLDEYREKEIEELQKIL--- -FDK-----ST-------GK-ALDSSVIRKR-------YQFLDEYREKEIEELQKLL--- ------------------------------------------------------------ -FDK-----SL-------GR-AEDLAKVRSN-------YRFLDDYRQQEISELSALL--- -FDK-----SM-------GK-SEEYDKIRQR-------YKFLDEYRQREIDELGTML--- -FDA-----AY-------GK-A-DLAKARKD-------YAFLDEYRKQEIANMESLL--- -FDK-----SL-------GK-SEDYESIRKR-------YKFLDEYRQKEINELTTML--- -FDP-----AY-------GK-A-NLDEVRKN-------YSFLDDYRQQEVQEMEQVL--- -FDA-----AY-------GK-A-DLIKARKD-------YAFLDEYRKQEIASMESLL--- -FDA-----AY-------GK-A-DLNQARKN-------YAFLDEYRKQEIANMESIL--- -FDA-----AY-------GK-A-DLRKIRKD-------YAFLDDYRKQEISNMEGIL--- -FDA-----AY-------GK-A-DLNRVRKD-------YAFLDELRQKEIAEMKAVL--- -FDP-----AY-------GK-A-DLRKTRKD-------YAFLDEYRQLEVKSMETML--- -FDP-----AF-------GK-A-NEERIRKD-------YSFLNEYRQSELEQMQRML--- -FDK-----ST-------GD-DIDVNSIRKR-------YAFLDEYRQKEIDELEGML--- -FDA-----TY-------GK-A-NEDRVRED-------YAFLDEYRREEIAELQAKL--- NDKKFVNKAESREIENMKEKVRSMKSRLQSVKNRELEQQIVKDYEGK----LNEGNKNR- HDRKFLSKISDREKSEMEQQVRRMKSRLETVQVMEMEQKIVKDYEAE----INKNNKNK- ------------------------------------------------------------ HDRKFVQKITDEDRETMQERLTSMKSRLQTVKNKDLERNIVKEYEDK----INSNNSTR- QERKFLSKIDQGEREEMEQRLKSMKSRLQSMKNKDLEREILKEYEND----MNKNNNTR- KDRKFLSKIDAEDREEMEQKLKSMKSRLQSMKNKDLERNILKDYEND----LNKDNSTR- KDRKFLSKIDQEDREEMEQRLKSMKSRLQSMKNKDLERDILKEYEND----INKDNSTR- QDRKFLSKIDHTDREEMEQRLKSMKSRLQSMKNKDLEREILKEYEND----MNKNNSSR- ------------------------------------------------------------ ADKKFLRKASEREVQQLQQRLTSMRSRLQTVQNRDTERQVLRDYERS----INQGNKTK- HDRKFLNKISAREKDELESKFTSMKSKLQTIQNRDLERQIVKGYEGD----INKGNKTK- KDKK--SRLNDDEREEIKLQLQSLKSRMDTLKNRDLENNILSNYKKQQMESFKEGKVNKP KDRKFLSKISDHERDEMEKRLTSMRSRLQSLQNRDLDRKILKDYESE----INKGNKTK- KKDR---NLSHFNKQKLEFKVQSLKSRLDTLNNRDLENKILSEHKKEQLAKFKSGSQANP KDKK--NKLNDDEREEIKLQLQSLKSRMDTLKNRDLENNILSNYKKQQMESFKEGKVNKP KDKK--SKLNESEKEEIRLQLQSLKSRMDSLKNRDLENLILKEYKKKQYQNVKEGKSSQP RDKK--NRLNDDEREEIKLQLQSLKSRMDTLKNRDLEESILKNYKKQQMDDFKSGKVNKP KNDKLRRKMSQREIEDLELQVKSLQSRLDTLKNRDLSTKIISDHKKQQMEKMKKGEQVNP KDKKSGQMLSNRDREEIQLQLQSLKSRLDTMKNRDLEEKILADHKRNQIKGFKDGQQNNP KDKKLSRSMSPRERQELELQTQSLRSRLDSMKNKDLEAQVLAEHKKQQKEKWKSGQQAAP KDRKFVNKLGDREYEDMQGNLKSMKSRLQTVKNRDLESKVIKEYEEK----INMGNKNR- KKTE-----ESYIRSQIQTQIQSLQSKLKTLEKRDFRKKVLNEHRQQQREQAKDGK--NP FHLKKAEKRKVIQKWKFDHMKAKQR--EKVMERKRKKKLGKEFKQF-------------- YHLKDSEKRKVIQKWKFEHMKGKQR--EKVMDRKRKKRLGKEFKQF-------------- ------------------------------------------------------------ YHLKESEKRKVIQKWKFDHMKSKQR--EKVMERKRKKRLGKEFKQF-------------- YHLKKSEKRKVVQKWKFDHMKAKQR--EKVMERKRKKRLGKEFKQF-------------- YHLKESEKRKVVQKWKFDHMKTKQR--EKVMERKRKKRLGKEFKQF-------------- YHLRKSEKRKVVQKWKYDHMKTKQR--EKVMERKRKKRLGKEFKQF-------------- YHLKKSEKRKVVQKWKFDHMKTKQR--EKVMERKRKKRLGKEFKQF-------------- ------------------------------------------------------------ FHLKKSEQKKVVQKWKFDHMKARQR--DKVMERKRKKLRGKEFRSF-------------- YHLKESEKRKVIQKWKFDHMKAKQR--EKVMERKRKKRLGKEFTQF-------------- YFLKRSDKRKILQKAKFDSMKPKQR--EKAMERKRKKRLGKEFRQL-------------- YHLKESEKRKVIQKYKFDHMKAKQR--EKVMDRKRKKRRGKEFKQF-------------- YFLKKSDKRKLIQKAKFDNMKTSQR--EKVMERKRKRRLGKEFKEL-------------- YFLKRSDKRKILQKAKFDSMKPKQR--EKAMERKRKKRLGKEFRQL-------------- HFLKRSDKRKILQKAKFDSMKPKQR--ERAMERKRKKRLGKEFRQL-------------- YFLKRSDKRKVLQKAKFDSMKPKQR--EKAMERKRKKRLGKEFKQL-------------- YYLKKSEQRKMIQKAKFETMKASQR--EKVMERKRKRKLGREFRQL-------------- YFLKRSDKRKLIQKAKFDSMKASQR--EKVMERKRKKRLGKEFRQL-------------- YFLKKSEKRKLLQKAKFESMKAPQR--EKVMERKRKRRLGKEMRQL-------------- YHLKESEKRKVLQKWKFDHMKAKQR--EKVMERKRKKKLGKEFKQF-------------- YYLKRSDQRKLVLTEQFKTMKKKDI--DRAIERRRKKITGKEKKDM-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EFHNR------------- ------------------------------------------EFHKR------------- ------------------------------------------------------------ ------------------------------------------EFHKR------------- ------------------------------------------EFHNRR------------ ------------------------------------------EFHNPR------------ ------------------------------------------EFHNRR------------ ------------------------------------------EFHNRR------------ ------------------------------------------------------------ ------------------------------------------EFHRK------------- ------------------------------------------EFHKR------------- ------------------------------------------EFKPTNR----------- ------------------------------------------TFHDR------------- ------------------------------------------EFNRH------------- ------------------------------------------EFRPTNR----------- ------------------------------------------EFRPLN------------ ------------------------------------------EFRPNNR----------- ------------------------------------------EFREPQR----------- ------------------------------------------EFNQPRH----------- ------------------------------------------EFGRK------------- ------------------------------------------EFHKQR------------ -------------------------------------------FSGRD------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----------------MSWDD------AGNAVLMDSWDAEAGDEPILDSWDEEEAAKPKP ----------------MSWDDEDFAVPSGSKPVLNSWDDENDDEPVLESWEDEETAKPKP ---------------------------MGNTVLMDSWDAEGDDEPVMQSWDAAEEKQPAP ----------------SNWDDDALTGSMGNEVLLNSWDDEIGDEPILESWDAE--EEPKA ----------------MSWDDEAINGSMGNAVLMDSWDAEGDDEPVMQSWDAEEEKKPAP ----------------MSWDDDAINGSMGNTVLMDSWDAEGDDEPVMQSWDAEDEKKPSS ----------------MSWDDEAINGSMGNVVLMDSWDAEGDDEPVMQSWDAEEEKKPAP ----------------MSWDDEAINGSMGNVVLMDSWDAEGDDEPVMQSWDAEEEKKPTP ------------------------------------------------------------ ----------------MSWDDEEFEVRTSTQPMVVSWDDEDDDDALLESWDAEPKQKQKP ----------------MSWDDEDFDIPTTAEPVMASWDDEDDEEPILDSWDAE--EKPKP ----------------MSWDDEDFDIPSNSKTVAASWEDEEDDGPVLESWDVDKKKKEAK ----------------MSWDDEDFEVPTSAQPAVASWDDEDDDEALLESWDAEPQQKPAA ----------------MSWDDEDFDIPSNSKQAAASWEEEGNDEPLLDSWDIDRKKKEEE ----------------MSWDDEDFDIPSNNKTVSASWEDEEEDDPVLESWDIDKKKKEAK ----------------MAWDDEDFDIPSNSKTAVS-WEDEEDDDPVLESWDIDKKKKAEQ ----------------MAWDDEDFDIPSNNSAAVASWEDEEDDDPVLESWDVDRKKKAAK ----------------MSWDDEDFDIPTSSKPAANSWEEEVEDEPLMDSWDVDKKKKAEE ----------------MSWDDEDFDIPSKANVASASWEDEEDDDPILESWDIDEEAELKK ----------------MSWDDDDFDVPAT-KTAGVSWEDEDNDDPLLESWDIDRKKKEEE ----------------MSWNDDDFAGSANNVVLMDSWDAE---EPIMESWDAEKETSPKP ------------------------------------------------------------ KPKAGGKKNAKGEEKQVLAIDELDPQTRKELMKKAELESDLNNAADLLGDLEMAEERARA KAAAAAAAKAPKKASTMLDIDTLDDKTRKELLRKAELESDLNNAADLFGGLGVAEERARA KPKKAQPNKAKKGKEALLDIDSLDEKTRKELIKKAEIESDLNNAADLFAGLGVAEERARA KKETAPKKAAGKKKSVESALDHVDEKTRKLLLKKAELDSDLKNAADLLGGLELEE-RARA KPKKEQPKKVKKGKEALLDIDTLDEKTRKELIKKAEMESDLNNAADLFAGLGVAEERARA KQKKEQPKSAKKSKEVLLDIDTLDEKTRKELIKKAEIESDLNNAADLFAGLGVAEERARA KAKKEQPKKAKKTKEVLLDIDTLDEKTRKELIKKAEMESDLNNAADLFAGLGVAEERARA KPKKEQPKKAKKGKEVLLDIDTLDEKTRKELIKKAEMESDLNNAADLFAGLGVAEERARA ------------------------------------------------------------ KAAPKAAKKVDKKGE-LLEIDTLDEKTRKELLKKAELNSDLNNAAALFDGLGVAEERARA KAKPAAKKADPKKKKVLLEIDTLDEKTRKELLKKAELESDLNNAADLFGGLGVAEERARA LQEAKRKAELKAKEDELEQFDQLDERTRKELLKKAELNADLNNAADLFGGLGVADDRERI SKKPAAAKKPAAKKDVLLEIDTLDEATRKELLRKAEVESDLNNAADLFGGLGVAEERARA AKKKAEKEALKKKQEALLDIDLVDENTRQELLKKAELDADLNNAADLFGGLGVAGERERA LQEAKRKAELKAKEDELEQFDQLDERTRKELLKKAELNADLNNAADLFGGLGVANDRERI EAEAKKKAELKAKEDEMEEFDGLDERTRKELLKKAELNADLNNAADLFGGLGVAEDREKA AEEAKRKAELKAKEDELEEFDQLDEKTRKELLRKAELNADLNNAADLFGGLGVAGDRERA EKKKAELKKKQEEAKKLMEIDMVDEETRKELLRQAELEADLNNAADLFGGLGVADDREKL KQEEAKLKKLNAKKGGVLDVDELDDDVRKELMKEEALRADLNNTADLFGGLGVSADKERL AKKKAEKEALKQKQQKLLDIDLIDEETRQELLRKAQVTSDLNNAADLFGGLGVANDRERA DSKKNAKKDSKKDKKVLLEIDVLDEKTRKELLKKAELESDLNNAAELFGSLGVAEERARA ------------------------------------------------------------ MQKEQELAAQRPTKDTPIEDHPLFKAETKKEYQDLRKALATAIVTMHEKSYSSSLAIDLI EREREQLAAVQPTKDTPIQSHPLFDLETKKDYQELRKALATAITSTSNKSYSGGLAIDLI LQKEQEEIALRPTKDTPIETHPLFNAETKKEYQDLRKALSTAIAPMNNKSYSSSLAIDLI LRKEEEATASIPTKETPIETHPLFAAESKRDYQDLRKSLATAIVSMNDKSYSSNLAIDLI LQKEQEEQALRPTKDTPIETHPLFNAETKREYQDLRKALTAAITPMNKKSYSSSLAIDLI LQKEQEEQAIRPTKDTPIETHPLFNAETKREYQDLRKALSAAITPMNKKSYSSSLAIDLI LQKEQEEQALRPTKDTPIETHPLFNAETKREYQDLRKALSAAITPMNKKSYSSSLAIDLI LQKEQEEQALRPTKDTPIETHPLFNAESKREYQDLRKALSAAITPMNKKSYSSSLAIDLI ------------------------------------------------------------ LRQEEELAALRPTKQTPFESHPLFEAETKSDFQDLRKALSTAIAGMAEKSYSGALAIDLI LRKEQELSALKPTKDTPIESHPLFEGETKADYQELRKALSTAITSMHEKSYSSALAIDLI TKQQLAAAAARPTKDTPLEEHPLFQPTNKQEYEKLRKTVGTSLTRLNEDSYASSLAVDLI ARKQKELEALQPTIDTPLDSHPLFNVESKKQYQDLRKALTSAITPLNEKSYSSGLAIDLI AKAAAAAAAATPTKDTPIDTHPLFQPTDRQEYEKLRKALAPVLTNLAEDSYSSGLAIDLI TKQQLAAAASRPTKDTPLEEHPLFQPTNKQEYEKLRKTVGTSLTRLNEDSYASSLAVDLI RLAALQAARSKPTKDTPLEDHPLFQPTNKQEYERLRKTLGATLTALSEDSYASSLAIDLI NKQKLAAAAARPTKDTPLEEHPLFQPTNKAEYEKLRKTLGTTLTALSEDSYSSNLAIDLI TIPVKKSSGF--NKDTPLTEHPLFQPTNKQEFEKLRKTLGPILSGLAEDSYSSSLAIDLI NRAILAAQSKKPTKDTPLEEHPLFQPTNKQEYENLRKGVGSALTKLADDSYSSSLAIDLI AKLAAAKQAAAPTRDSPLEMHPLFQPTDKAEYEKLRKALATSLQQLAEDSYSSALGIDLI LRKEQEVADARPTKDTPIESHPLFNGESKKDYQDLRKALATAIVTMNEKSYSSSLAIDLI ------------------------------------------------------------ RDVSKPMSIENIRQTVATLNILIKDKEKAERQARGGTATGGAGKKKAKAKTNLQDFDVDI RDISKPMTVENIRQTIATLNVLMKDKEREERQARGGTATGGAGKKKAKTRANLNDFDLND RDVAKPMSIESIRQTVATLNVLIKEKEREERQARGGTATGGAGKKKAKGKTNLQDFDMTD RDISKPMSIESIRQTVATLNVLIKDKEREERQARGGTSTGGAGKKKAKAKTNLNDFDMDM RDVAKPMSIESIRQTVATLNVLIKDKEREERQARGGTATGGAGKKKVKGKTNLQDFDLPD RDVAKPMSIESIRQTVATLNVLIKDKEKKERQARSGTATGGARKKKGKSNTNLQDFDLTD RDVAKPMSIESIRQTVATLNVLIKDKEREERQARGGTATGGAGKKKVKGKTNLQDFDLPD RDVAKPMSIESIRQTVATLNVLIKDKEREERQARGGTATGGAGKKKVKGKTNLQDFDLAD ------------------------------------------------------------ RDVAKPLSIESIRQTVATLNVLIKEKERQERQARGGTATGGAGKKKAKARPNLQEFSLNS RDISKPMSIESIRQTVATLNVLIKEKERQERQARGGTATGGAGKKKAKARPNLQEFDMSA RDLSQPLSVENLRKVISTLNVVIKDKERQERQARGGTATGGAGKKKAKARPNVAFDDMDG RDVASPMSVESIRQTIATLNVLMKDKERQERQARGGTATGGAGKKKAKAKANLQEFDLNS RDLAQPLSIESIRKVVSTLNVILKEKEKAERQARGGTATGGAGKKKAKVKTNVVFDDIQS RDLSQPLSVENLRKVISTLNVVIKEKERQERQARGGTATGGAGKKKAKARPNVAFDDMDG RDLTQPLSVENTRKVVSTLNVVVKDKERQERTARGGTSTGGAGKKKAKARPNVEFDDM-G RDLSQPLSVEHLRKVISTLNVVIKEKEKQERQARGGTATGGAGKKKAKARPNVAFADLDG RDLVQPLSVENVRKVISTLNVTLKDKERQERQARGGTATGGAGKKKAKVKTNVVYDDMDA RDLSVPLSVENLRKVISTLNVAIKDKEKAERLARGGTATGGAGKKKAKARPNVGLDEM-D RDAAQPLSLENVRKVISTLNVIVKDKERAERQARGGTATGGAGKKKAKVKTNV-----GD RDVAKPMSIESIRQSIATLNVLMKDKEREERRARGGTATGGAGKKKAKAKTNLQEFDMVD ------------------------------------------------------------ NDFGADDFMLFRCAVTRISVQISRNLANSQNKRRLNTKSYFLQEQKKDDSILTDDLLFKA NDFGEDDFMIARVSLLRARMVPVHAMQMRVVRRSLHNGSLLLQKKNEKNSILDDDMLARA DDFADDDFMILRNSVRLLGIVPSAARTLAVSKRLLTNSSTLLQKETKDDSILTDDMLFKA NDFGDDDFMIARQLCRARMAAPAVLSAVSLKRNLHYSSTMLDAKKKKEGSILTDDLLAKA DEFGDDDFMILRNSVRLLRVVPSAANTLTASRRLLTSYSSFLQKETKDDSILTDDMLFKA DEFGDDDFMILRNSVRLLRTLPSTTGTLVVSKRLLTSSPAFLQKETKDESILTDDMLFKA DEFGDDDFMILRNSMRLFRTVPSVATKLAVSKRLLTSSTRLLQKETKDESILTEDMLFKA DEFGDDDFMVLRNSVRLLKIAPSVVSTLTVSKRLLTSSPSFLQKETKDDSILTDDMLFKA ------------------------------------------------------------ EAFGDDDFMVIRRSRATARQLPRVAGLLAAVRSRTYIGTRILHEEQKPKSILTEDMLARA DDFGEDDFM--------------------------------------------------- QDLDDDDFMMFRTQSRYHCVLPSTRMAVSNQSIKFYSSKDNATDKSQEKSILNDDMLARA NDFAEDDFMTLRRTV--CRKAQFHAQLSSVPLIRPFSSSIRVFEATKDESILTEDMLAKA KDFEEDDFMNTRLLTRTLRFAA-------TKNTRLPTQHKFYSKKTDKKSILTDDLLAKA QDLDDDDFMMFRNQSRHHRVLPSTHTAVSNQSIKFYSSKDNAADKSQGKSILNDDMLARA ADLDDDDFMALKNASKPRTSSTVLLPRLHSIKYYSTSKDQSAADQKRKESILNDDMLARA QDFDDDDFMMLRTQSRYVRASSTTRVALPVKFYSTKDNNNATDKKQQEESILNDEMLARA NDFGDDDFMILRA----LPLHGASQARLAPVVRSNFGGWRRFYAEKKDESILTDDMLAKA NDFGDDDFMSVRSLVARLAQMPSVYAVSAVSRTVSRIGPVSFYSTNKTESILTDDLLAKA DDFDDDDFMIRAVRASLVLSRQPVA---------RTNIVKYYSDKKVNESILTDDMLAKA TEFGDDDFMLLKSSTRIRPNVIQRHLSYSYDGKNKPDAEGDTSASKKGDSILTDDMLFKA ---------LLRAAQIARVARPGVKRAMTPAVRFYSDKKTEKSDQPFQSSLLNDDLLAQA GIDVEGKKEGGSENSSNKKRKRRMTSADKKKERYANYFYIFTFSSLAGLGLYMCRDWEEN GVEVGNEAGSGGDKGSGKKKRSRKSSTDIKRERYANWFYILSLLGLASGALSMARDWDSD GVDVDENGQAEPSSQGEKSKRRRQTSTDIKREKYANWFYIFSLSALAGGTIYMARNWEPQ GLDVEMNAKKSSGEAKTRKKRSRKTSTDIKREKYANWFYIFSFSGLAGGALYMTRDWDAS GVDVDEKGQGSPSSKSEKSRRKRQTSTDIKREKYANWFYIFSLSALTGTAIYMARDWEPQ GVDVDENGQGAPLSRTEKSRRKRQTTTDIKREKYANWFYIFSLSALTGSAIYMARDWEPQ GVDVDENGQGVTSSKGEKSRRKRQTSTDIKREKYANWFYIFSLSALTGTAIYMARDWEPQ GVDVDEKGQGAPSSKAEKSRRKRQTSTDIKREKYANWFYIFSLSALTGTAIYMARDWEPQ ------------------------------------------------------------ GVDARGPETESTGSGAGKKKRARKTTTEIKRERYANLFYLFSLTGLAGGAVYMSRDWDAD ------------------------------------------------------------ GFEDDPKEETA-----GRKRKRAQTSKDLQRERYANMFYLSALIFGVAGVGYMSRDWDSE GVDVEPSTGEKSNETGGKRKRKRQTSTDIKRERYANWFYVASFAALTGAGAYMARDWDEN GFEDNEPKEKGGQEQRSRRKRRAQTSKDIQRERYANMFYLATLVGGIAGVGYMCRDWDSE GFEDEPKEETQSTKQTGRKRKRAQTSKDLQREKYANMFYLSALLFGVAGIGYMSRDWDSE GFEDDSRNEQTETGSNKRKRRRAQTSKDRQRERYANIFYLTTFAGGIVGLGYMARDWDSE GFEDDPKEKSSSDKRSERKRKRAQTSKDLQREKYANFFYLSTFALGLGGLAYMSRDWDSE GFEDPKNEENE-----ARRRRKAQTSKDIQREKYANWFYISTLFGTFAGVGWMCRDWDSD GFEDPEK---GSEQGPRRRRKRAQTSKDLKRERMANYFYLLTFAGAILGVGYLCRDWDSE GFDDENGKKDGAERTRAKRRRRAQTSKDLQREKYANYFYGFTLFGALAGVGYMCRDWDSE GVDVEGTSGKASESGHTKKKRKRQSSTDIKREKYANWFYIFTFSSLAGVSLYMTRDWEEN GMDVESKGKSDARWAGTAKKSTDQTSKQESRERIAGYGYYAFFAGSAAFAAYLARDWDNE EDDEMKKDITPDLMYKRFRARFNSVFTYFQEPPFPDLLPPPPPAYQRPLTLVITLEDFLV ESEELKKEITPALMYKRMKRRWESIFTFFQEPPFPDLLPPPPPPYQRPLTLVLSLEDLLV EAEELKKDITLSLMYKRFKARFNSMFTYFQEPPFPDLLPPPPPAYQRPLTLVITLEDFLV EPEEIKKDISAGLMYQRFKARFNSMFTYFQEPPFPDLLPPPPPAYQRPLTLVITLEDFLV ESEELKKDITLSLMYKRFKARFNSMFTYFQEPPFPDLLPPPPPPYQRPLTLVITLEDFLV ESEELKKDISLSLMYKRFRARFNSMFTYFQEPPFPDLLPPPPPPYQRPLTLVITLEDFLV ESEELKKDITLSLMYKRFKARFNSMFTYFQEPPFPDLLPPPPPPYQRPLTLVITLEDFLV ESVELKKDITLSLMYKRFKARFNSMFTYFQDPPFPDLLPPPPPPYQRPLTLVITLEDFLV ------------------------------------------------------------ EPEEERKGITPGLMYRRFKARFDSLFTFFQEPPYPDLLPPPTSPYQRPLTLVLPLEDFFV ------------------------------------------------------------ KEEMDGKNVTPKLMYERLSKRLGSLFTFFSEPAFENLLPPPPPEYRRPLTLVVTLDDFLI EPEDLKKGATPGLMFQRLKLRFNSIFSYFQEPPFPDLLPPPPPPYQRPLTLVLTLEDLLV DEKLEGKDIAPNLMYGRLNKRLGSLFTFFSEPVFENLLPPPAPEYRRPLTLVVTLDDLLI KEDMDGKNVAPKLMYERLSKRLGSLFTFFSEPAFENLLPPPPPEYRRPLTLVVTLDDFLI KEDLDAKNITPGLMYERLSKRLGSLFTFFSEPAFENLLPPPAPEYRRPLTLVLTLDDLLI KEDMDGKNITPKLMYDRMSKRLASLFTFFSEPAFENLLPPPPPEYRRPLTLVLTLDDLLI EERLDASDITPKLMYDRFNKRFSSLFTFFSEPAFENLLPPPPPEYRRPLTLVLSLDDLLI EEALEAQEVTPGLMYARLNKRLSSLFTFFSEPAFEDLLPPPAPEYRRPLTLVLSLDDLLI EEALDGTDISPGLIYGRFNKRLSSFFSFFSEPVFENLLPPPPPEYRRPLTLVLTLDDLLI EPKELKDAVTPGLMYKRFKARFNNLFNYFQEPPFPDLLPPPPPPYQRPLTLVVSLEDLLV EDKKKHDTITPMLMWARLKARIGDTFSFYRDPVAPVLLPDPPAPYQRPLTLVIALDDLLV HSEWDQKHGWRTAKRPGADYFLGYLSQYYEIVLFSSNYMMYAEKIAEKMDPIHFISYNLF HSEWTQQSGWRTAKRPGVDYFLGYLSQYYEIVLFSSNYMMYAEKIAEKLDPIHFITYNLF HSEWSQKYGWRTAKRPGADYFLGYLSQYFEIVLFSSNYMMYSEKIAEKLDPIHFVSYNLF HSEWSQKYGWRTAKRPGVDYFLGYLSQYYEIVLFSSNYMMYGEKIAEKWDPLHFISYNLF HSEWSQKHGWRTAKRPGADYFLGYLSQYYEIVLFSSNYMMYSDKIAEKLDPIHFVSYNLF HSEWSQKYGWRTAKRPGAEYFLGYLSQYYEIVLFSSNYMMYSEKTAEKLDPIHFVSYNLF HSEWSQKYGWRTAKRPGADYFLGYLSQYFEIVLFSSNYMMYSDKIAEKLDPIHFVSYNLF HSEWSQKYGWRTAKRPGADYFLGYLSQYYEIVLFSSNYMMYSEKIAEKLDPIHFVSYNLF ------------------------------------------------------------ HFEWTQQYGWRTVIRPGADYLLGYLSDYYENVLFPSNYMVYSKKVVEKLDPIRFITYNLF ------------------------------------------------------------ HSNWDTQHGWRTGKRPGLDYFLGYLSQYYEIVVFSSNSQIYSDKTVNKLDPYHYISYALF HSEWTKDHGWRTAKRPGVDYFLGYLSQYYEIVLFSSNYMMYSDKVAEKLDPIHFITYNLF HSDWDTKHGWRTGKRPGLDYFLGYLSQYYEIVIFGSNYQMYSENTVGKLDPFHYVSYALF HSNWDTQHGWRTGKRPGLDYFLGYLSQYYEIVVFASNLQIYSDKTVNKLDPYHYISYALF HSEWDTKHGWRTGKRPGLDYFLGYLSQYYEIVLFCTNSQIYSEKAVSKLDPYHYISYALF HSNWDTQHGWRTGKRPGLDYFLGYLSQYYEIVVFSSNSQIYSDKTVNKLDPYHYISYALF HSEWDTKNGWRTAKRPGLDYFLGYLSQYYEIVIFGSNSQMYSEKTVAKLDPLRYIQYALF HSNWDTKNGWRTAKRPGLDYFLGYLSQYYEIVIFGSNYQMYSEKTVLKLDPMHYVSYALF HSEWDTKNGWRTAKRPGLDYFLGYLSQYYEIVIFGSNSQMFSEKVVAKLDRYHYISYALY HSEWTQKNGWRTAKRPGVDYFLGYLSQYYEVVLFSSNYMMYSEKIAEKLDPIHFISYNLY HQEWSREHGWRVAKRPGVDYFLGYLGQYYEIVLFSSQYMANCEKLIMKLDPYHWFSHVLT KEHCVYKDGVHIKDLSKLNRDLKKVMIIDTDENSYKLQPENAIPMDPWDGKADDKLLRLI KEHCLYKDGVHIKDLSKLNRDLGKVLIIDTDENSFKLQPENAIYLEPWDGKADDRLLRLI KEHCVYKDGVHIKDLSKLNRDLSKVIIIDTDPNSYKLQPENAIPMEPWNGEADDKLVRLI KEHCVYKDGVHIKDLSKLNRDVNKVLIIDTEPNNYKLQPENAIPVKPWDGKADDELLRLI KEHCVYKDGVHIKDLSKLNRDLSKVIIIDTDPNSYKLQPENAIPMEPWNGEADDKLVRLI KEHCVYKDGVHIKDLSKLKRDLSKVIIIDTDPNSYKLQPENAIPMDPWNGEADDKLVRLI KEHCVYKDGVHIKDLSKLNRDLSKVIIIDTEPNSYKLQPENAIPMDPWNGEADDKLVRLI KEHCVYKDGVHIKDLSKLNRDLSKVIIIDTDPNSYKLQPENAIPMDPWNGEADDKLVRLI ------------------------------------------------------------ KDHCVYKDGIHIKDLSHLNRDLGKTLIIDTDPNSVKLQMENAILAEPWDGKADDALLRYI ------------------------------------------------------------ REACRYKDGKLIKDLSLLNRDLGKTVMIDVDEDSAALQPENSIIVKKWEGQPDEYLISLI KEHCLYKDGVHIKDLSKLNRDLGKTVIIDCDPNAYKLQPENAIPMKPWDGKADDGLLKLI REACRYKDGKLVKDLSLLNRDLGKTVLIDVEEDSWSMQPDNAIPMKPWDGSYDDTLVKLI REACRYKDGKLIKDLSLLNRDLGKTVMIDVDEDSAALQPENSIIVKKWEGQPDEYLISLI REGCRYKDGKIIKDLSLLNRDLGKTVLIDVDEDSASMQPENSIILKHWDGKPDDYLIRMI REACRYKDGKLIKDLSLLNRDLGKTVMIDVDEDSASLQPENSIIVKKWEGQPDDYLVRLI REACRYKDGKLIKDLNLLNRDLAKTVAIDVNEESLCMNPENSIILKPWDGKPDDTLVKLI REACRYKDGKLIKDLSLLNRDLGKTVIIDVEPESVSAQPENALIVKPWDGKSDDYLIQMI REACRYKDGKLIKDLSLLNRDLGKTVLIDVNEESWAMQPDNAIPMKPWDGKPDDNLVKLI KEHCVYKEGDHIKDLSKLNRDLGKVIIVDTDPASYKLQPENAIPMQPWDGKADDKLMRLI REHTTYEDGKLVKDLSLMNRDMGKIIIIDPDTGCTMKQPENSIPIEPWKGTPGDKLVKLI PFLEYMATQQVEDVRPILKSYNKRELPAEFEQRVQKLKNKFEQDDSNWLLKLLGLAGGNK PFLEYLATQQVSDVRPILKSFDNKNIPEAFEKRVQVLKEKFERDDKNLFLKLLGIGGTPK PFLEYLATQQTKDVRPILDSFDKKNLATEFDHRVKKLKDKFHGENGNWALKVLGVK--QK PFLEYLATQQTEDVKPILNSFDKYELPEEFNNRVIKLREKFEKDDGNWALKALGVAG-SK PFLEYLATQQTKDVRPILNSFDKKNLAEEFDHRVKKLKDKFYDHGGNWAMTALGLGGSTK PFLEYLATQQTKDVRPILDSFDKKNLATEFDHRVKKLKDKFYDAGGNWAMKALGVGGSTK PFLEYLATQQTKDVRPILNSFDKKNLATEFDHRVKKLKDKFYDHGNNWARKALGVAGSTK PFLEYLATQQTKDVRPILNSFDKKNLATEFDHRVKKLKDKFYDNGGNWAMKALGIGGSTK ------------------------------------------------------------ PFLEYLVTQPINDVRPILNSFDRHHIPEEFAERVEKLRAKFNADGSGL--SFL---SKAK ------------------------------------------------------------ PFLEYLATQPVKDVRPILNSYDKSNIVAEFAERENKLREQWRKDAGNFIAKLLGIPVPPK PFLEYLATQQTEDVRPVLNSYDKFKIPEEFERRVAVLKSKFYKDNGSFFLRALGTGGQAK PFLEYLATQPVKDVRPILNSFDKSNIVQEFAEREAKLREQWKKDAGNFLASLMGVPNKPK PFLEYLATQPVKDVRPILNSYDKSNIVAEFTERENKLREQWKKDAGNFIAKLLGIPVPPK PFLEYLATQPVKDVRPILNSFDKSNIVDEFSERERKLREQWSRDAGNFLAKFLGMPVPQK PFLEYLATQPVKDVRPILNSFDKSNIVSEFEVREARLREQWKKDAGNFLAKLMGMPTSPK PLLEYLATQPIKDVRPILNSFDKSNIIAEYEKREAQLRARWREDAGSFFASLMGIPNRPK PFLEYLATQPVKDVRPILNSFDKSNIVEEFAQRERKLREQWAHDAGDFIGKLLGLPRKQK PLLEYLATQPVKDVRPILNSFDKNNIIEEFSEREAKLRQQWMKDAGTYLAKLMGVPNKPK PFLEYLATQQVSDVRPILESYDRNAIPEEFDERVRKLKEKFYNDDSNWMLNIAGVPTQTK PFLEWLVSQNVNDVRPILKAFDGTYLPDEFTRREAIAREKFEKDDGQWASKFLGVSKQKP FPLDMIREEGEKNYVRFMKLIEEEKEKMRIQQEQMSGQTFTLDYVEGNITPMVAKVWSRV FPLDLIREEGEKNYVRFMKLVEEEKEKIKLQQQAMGQQTFTLDYVEGNITPVNRAIYVLT FPLDLIHEEGQKNYLMFMKMIEEEKEKIRIQQEQMSGQTFTLDYVEGNLSPMVRVLPVVL FPLDLIREEGEKNYVRFMKLIEEEKEKMRIQQEQMSGQTFTLDYVEGNITPLISSFPLPL FPLDLIHEEGQKNYLMFMKMIEEEKEKIRIQQEQMGGQTFTLDYVEGNLSPMVRILPIIL FPLDLIHEEGQKNYLMFMKMIEEEKEKIRIQQEQMSGQTITLDYVEGNLSPMVRVLSVIL FPLDLIHEEGQKNYLMFMKMIEEEKEKIRIQQEQMSGQTFTLDYVEGNLSPMVRILPVIL FPLDLIHEEGQKNYLMFMKMIEEEKEKIRIQQEQMSGQTFTLDYVEGNLSPMVRILPIIL ------------------------------------------------------------ FPLDLIREEGEKNYVRFMKLIEEEKEKLKLQQEHMSAPTFTLDMAEGNMTPMYWKKLLFA ---------------------------------------------------MLWSLFLLP MPLDIIREHGQLQYEHFQKYLQENAHKFLEEEQKLKDEKVTLKLITEGANA---MKFSVL FPLDLLREEGEKNYVRFMQLIEEEKEKIRIQQEQMGGQTFTLDYVEGNLSPMYWFPLLVQ MPLDIIREHGQLQYEHFQKYLKENAPKFLEEEQKLKDEKVSLKLITEGASAMKLLKGVLS MPLDIIREHGQLQYEHFQKYLQENAHKFLEEEQKMKDEKVTLKLITEGANP---MKFSVL MPLDIIREHGQLQYQHFQKYLQENAKKFLEEEQKLKDEKMTLKLITEGANPMNKKLILVA MPLDIIREHGQMQYEHFQKYLQENAHKFMEEEQKMKEEKVTLKLITEGANPHTYMKFSVL MPLDIIREHGQMQYESLQKYLKENEAKFLEEERKMKEEKVTLKLMTEGMTAGSHFAFFPF MPLDIIREHGQFQYEQMQKYMRENAQIFLEEEKKNKEEKVSLQLLTEGAKPLMKIQWLLF MPLDIIREHGQKQYEHFQKYLQENGEKFIQEEEKLKEKKTSLKMITEGPSP--------- FPLDMIREEGEKNYVRFMKLIEEEKEKIKIQQEQMSGQTFTLDYVEGNITPMMNAKFWCC LPHDVMRREGQKQYQKFLEYLAVEGPKLKAEEERMIAEAMGPNLIGSLPVPMKFSKTLLL ILIFIATVM------------------------VFASSQQGDANKVNTASPPG------- VLLFSRLVVLTPSNSNADPKQHLVCNTKECYPIGFVPSTEWKEIRPGQRLPPGLDIRVSL AALSLELVAVSQSIIQPVYPRNSICSNGRCYPRIFEPRYDWQSILPGQELPGGLDIRINM LLVLSQVMALAPKSTPPTAHMTLICDDDKCYPRVFKPSKDWQIILPEQQLPGGLDIRLNL SALSSKLVAILHSSIHSVPSGNSICVDNRCYPKIFEPRHDWQPILPGQELPGGLDIRINM TALSLKLVTTSQGIIRSVSSRNSICGNSRCYPRIFEPEHDWQPILPGQELPGGLDIRINM SALSLRPVIVSPSPLNSETSRSSICVDGNCYPKIFVPAHDWKPILPGQDLPGGLSIRINM TALSLKVVAISHLPIPSVPSGNSICVNGRCYPKLFEPGHDWQPILPGQELPGGLNIRINM ------------------------------------------------------------ IASAAALAAVDPETEGSEL--QTICSGGECYPRLFKALQDWSTIKEGQQIPPGLDIRVDL VVIATELITLTPSSKPESSLHSLICNDKECYPKVFEAKEYWQEVRPSQLLPAGLDIRMNL VLLASYLVGVNSSIVDTSE--ELICNPLDCYPKLFVPTNEWQTIKPGQDIPPGLHVRLNI ATLAHELVTLAPSSQDPEVSQKLICNSQECYPKLFEPENYWKEIRPSQHIPGGLDVRMNL SILLTLLIKIESLIVNTDG--ELICNPTDCYPKIFEPTTEWQTIREGQDIPAGLHVRLNM VLLASYLVGVSSLIVDTSE--ELICNPLDCYPKLFVPTNEWQTIKRGQDIPLGLHVRLNI ISYLFTL--IHSSSTNNRGNKDIICNLDNCYPRIFEPTSEWQLIKPGQDIPPGLHVRLNM VIIAFQLLSIRASIVDTAE--ELICNPLDCYPKIFVPTKEWQVIKEGQEIPPGLHVRLNI LFNFASLSTISPLYAHTSPPDEVVCNVAHCYPKVFKPTDEWQTVREGQDIPPGLHVRLNM IAA------AAASIVDTET--DLICNPTDCYPRIFVPTSEWQNIREGQDIPAGLHVRLNI ------------------------------------------------------------ LLVCLSIVYISPNKVSQVVSESQICNQVTCYPKVFEPSNEWKEVKPHQIVPAGLHVRVDM ALVAGALAK------------DEICNSGKCYPKVFVPTEEWQVVWPDQVIPAGLHVRMDY ANGIAYASVVAGGSN--------------HVSAA-------------------------- EKGVREAKLPEPGSEVLGAEGSTLSESELKETSEDLEKLNNAEKESDILQQETDLKIAVS ETGSKEAKLNDDDSE------GDNGTHDLVVSSENME------------------PPTDN ETGLKEAKLLDENDKSSFNVSGTKSTANELVPRDNVESSTSSSTPIPSPTPLVEIDTTSP DTGLKEAKLNDEKNV------GDNGSHELIVSSEDMK------------------ASPGD ETGLKEAKLDSEES----------GSHDIIIYPGNMK------------------PSADD ETGLKEARINDEDIS-------NSSSNELVVSLEDVE------------------PSIDD ETGLKEAKLNDEESV------NNNDSHELVISSEDTK------------------ASPDD ------------------------------------------------------------ STGKKQARLPIPNEA-------SNMENGIQVVDDSSD----------------------- ETGSKEAKNGESNQL--------------SEVPSE------------------------- DTLEKEAKLMSADEKQEVVVGGELQDHSREAITENLQHESKHPEVKQEHAHRTKVSQGDL DTGLQEAKLGSSPEA--------------IPSAPAAT----------------------- ENLAREAKILDPSEEVNAEQNNDNGDNSHQMTNEDQAEIQQKIKEFKQTQGKSKVSTVDL DTLEKEAKLMSTDGKQEVVVGGELQDHSKEAISENLQHERKHPQVKQEHALRTKVSKGDL ETLEKEAKLMEREEEVELIVGENNGDNEAGETAKEQTIQQQILKAKTGYKPKSRVNAEDL DTLEKEAKLMDDDIKQELVVDGEVQDHSNEAIQENLQHERKHPEVKQDHSHRSRVNQDDL ETGEREAKLVSEEDSVPVLVEGAQVESE-VPIEQKIQETLKKYKQEQMNFRKSKVSESEL DTLQREAKLMEPEQAIVLVPGEEVHDVPEDLAQDEIQEFRQQKLQKQAEPYQDQINHDDL ------------------------------------------------------------ SSGLKEAKIDAEYGKSASASASTSASSSSISASSSASTSTSTSTPTSTSTLTKPEETKDD ENGVKEAKINDPNEEGEVVIEDLTEENGDEGISANEKKAIKEKRIKEGHKPNPNIPESDH GSVTGDGVQLPNAEV---DIDWLEEHLED----SHDYEKGYDLVEQHFNKLL-VGNNADA HEFSEDFAKIKSLMQDEKTWEEVETLLDDLVEFAHDYKKGFKILSNEFELLEYLSFNDTL YEFSSDFQGIRSILDSPHDISVLEDTFDRVMEFAHDYKHGYKIIVHEFPLLANVSLNEEL YEFSSDFNEIRELLSSSSSQDTIETIFDNVMEFAHDYKHGFKIMTHEFDLLKNITFNDRL YEFSSDFKEMRNIIDSSQDIARLEDSFDRIMEFAHDYKHGYKIITHEFALLANLSLNENL YEFSSDFNDIRSIINIPQDITILEDKFDKVMEFAHDYKHGYKIIVHEFSLLANVSLNEAL YEFSNDFQEIRGIIDSPHNVTILEDKFDKVMEFAHDYKHGYKIIVHEFALLTNVSFNENL YEFSSDFKEMRNIIDSSHDISILEDKFDRIMEFAHDYKHGYKIITHEFALLANVSLNENL ------------------------------------------------------------ YEFTKEFQLVRAQVAGAPDYNVVIKQLDDLVEYASDYTLGYKIITHEFTLLQELIFGQDV YEFSRDFNKIRTLLNTEKDYSDIESILDDLVEYSHDYKHGYKILTHEFKLLQQLAFDHTM SNFDAACSEIESFKPHESDVERLHLALDTLEELSHDIEFGVKLTSDKFQSLVNIANGAS- HEFSEKFEQIKDLTS-SGNFADAEIILDDLLEFSHDYKHGYKIVSHELPLLKQLALSPDY NDFQSSVDEVQHYRE-GGDANRLSTALDTLIDLSHDIEFGVKLTQDSFRSLVDVSKSVQ- SNFDAACLEVENFKPHESDLERLHLALDTLEELSHDIEFGVKLTSDKFQSLLNIANSVS- TNFDSALNEVEQYDAENNNKERFELALDTIQDYVHDIELGVKLTSSKTVLRKLIDLAESG NDFDSASLEVEGYKPNASDMDRLNTALDTLEELSHDIEFGEKLTTDKFQSLLNIADTAN- SDYASSVEELLHFGK-NADVSRLEKALDTLIDLSHDIDFGERLTRDPFSSLLDAAQLTSS TSFDSAVAEIISFSG---DNSRLSQALDTLIDLSHDIEFGVKLTASRFDSLLEIGQSHK- ------------------------------------------------------------ HEFSADFKIIQNVLQSDQDIETIEWKFDDLMEFAHDYKHGLKIIKNEFDLLSSISFNETL QTFSDAVAALRDYKV-NGQAAMLPIALSQLEELSHEIDFGIALSDVDLNALLQILEDAKV SFKVRELASRLILGTLRNNPPVKRLIWDQHPLFVSQVFDLYNALKQGSGNPLKYPLLKRY SIQIRELAARIIVSSLRNNPPSIDFVNEKYPQTTFKLCEHLSELQASQG---SKLLIKRF PPTLRELSTRVITSCVRNNPPVVEFISVNFPNFKSQIMAALSKLNDSNH-KFSNILIKRY SPNLRELSARMMTSCLRNNPPVSDFVVSYHPTFIDETFTQIDKLIKENNMKSKQFLLKRY PLTLRELSTRVITSCLRNNPPVVEFINESFPNFKSKIMAALSNLNDSNH-RSSNILIKRY PLTLRELSTRIITSCVRNNPPVVEFINENFPNFKGQIMAALSKLNDSNH-KVSNILMKRY PLTLRELSTRVITSCVRNNPPVVEFINENFASFKSKIMIALSNLNDSNH-KSSNILMKRY PLTLRELSTRVITSCLRNNPPVVEFISEKFVNFKSKIMAAVSNLNDSNN-RSSNILIKRY ------------------------------------------------------------ PISVKELSSRIIVACLRNNTPCLDFVNTRFPDFVRHLLQEAVDYGRQATAVEARTQIKRY PMSTREISSRILASCLRNNPPVIDFVNANYPSFIQELQSQMCLFPRKSPSQHEKTLIKRY DPKITEKVYRVMGSSLRNNPEAISNILTNFDSYVDNLFEQL--------ANENDVLQKRI PISTRKLSSAMLTGSLRNNPPAVAYILDADPRFVTEVFSAIHAILAEPRTAETGILVKRY DEDLQEKVYRIMGSSLRNNPDAVNHVLKNQDTFVECLFDKL--------TDASDVIKKRI DPKVTEKVYRVMGSSLRNNPEAISNILTNFDSYVDNLFEHL--------PNEDDVLQKRI DGELKSKVYNIIASSLRNNPEAVQNIIDGRSAFTKSLLGQL--------ELASDLVQKRI DAKVEEKAYRIMGSSLRNNPEAINNLLSNFDDFVTNLFSQL--------SKKDDVLQKRI ESQIPEKSFRIMGSSLRNNPAAVTNVFEKQDNFMVTLFATL--------PETSDVVRKRI DDEITEKVYRIMGASLRNNPDSVTNLLRNLDSFVAALFSNL--------STQKDVIQKRI ------------------------------------------------------------ PNSVRELSTRVITSCIRNNPPVIKHIIETYPSYIDELFGALKTMESQKT-VAAKTLIKRY DVESKIMAARTIGASLRNNPHALDKVINSKVDLVKSLLDDL----AQSSKEKADKLSSSL LSILLELIPFNRDFRFEEDYKLDKLYTESDVPSDIKIKVLELITLDYSN----------- LSILDVL-LSRTEYVSIKDDVLWRLYQ--IEDPSSKIKILEIIAKFYNEKNEQVITVQQD LSILNELPITSQDFPLYSTTVLQNIYDENSGDKQLQIKVLELISKIFKTDVKEDENAENW ITILDELIESVHSFTKERMETLQSIYLG-IQDRQIKVKVLELISKCFMA----SKDVDAK LSILNELPVTSEDLPIYSTVVLQNVYERNNKDKQLQIKVLELISKILKADMYENDNAENW LSILNELPATSQDFSIYSTTVLQNIYEQNSNDKQLQIKVLELISKILKADMSENENAENW LSILNELPLTSQEFSIYSPAVLQNIYEQNKNDKQLQIKVLELISKIFKAGIHENENAENW LSILNELPVTSQDFPIYSTVVLRNVYEGNNKDKQLQIKILELISKIFEADMYENDNAENW ------------------------------------------------------------ LSIVEPL-LINEPQPINEEA-LKQLYE--VNDQTVQLKVLLIMARLYKGRSHNDDSLE-- LSIMQAL-LTRTSVELDEDA-LLELY--HIDDKQIRVRVLEIVSKLYHNDVPTDPSLE-- LGIIQALVFVRQYFSFHSSGLLIAIFPKLGPNSKSRASNILEDLQLFPVTN-DRRSLED- LSITQAL-APQASWDLNQEVLLEACQ---WGDEQIKMKALDVVAHLYRDESSIGTSQE-- LGIIHALTFNAKYFNSANSAVLISVFPSLESQSQTRLMNILEDLKLLGGANSNEKAIEES LGIIQALVFARQYFSFHSSGLLIAIFPKLGSSSKARASNILEDLQLFPATN-DRRSIED- LGIVQALTFVESFFTFHNYGLLVENFTKLGPQAKTRAANILQDLDLVGKSN-DRRSLED- LGIIQALSFTREYFSFHSSGLLIEIFPNLGVESQTRASNILEDLQLFPVTN-DRRSLED- AGVIHALAFAYQFFNVKSLGFLLRIFPKADHETQERIAMLFEDLNLLPSSPDKRD--EDS LGIIQGLAFAYEYFSHKNHGILISVYPQLGPDSRERCVNILEDLNLLSRDDFDRRAVEEF ------------------------------------------------------------ LSILDVL-LDESDFKLTHAELLTNIYNS-LKDKQIRLKILEIITRFFNQDPAATSNSEKL VYALSAVLTVTRFVDL--HGGLRQLYETGSDDVKGRVSTLIEDVLATPDLHNDFSSANWW IKGASGWIDRITNVLTDSELDELHKRTFFNAMHALKSEDPKLKLPTNFLNWLAQETKERA MKTVQKWVNELTTIIQTPELDELHLRSFFHCISFIKTRKNRVKIDSDFLNWLIDEIEVRN SQNLQEWASAFQEMVQNKDIDELHTRTFFETLYNLKKVKNDIAINKDFLNWLAHQSEHRQ IPNVQDWVNEFAQVIQDKEIDEWHIRKFFDSLYNIKKSKKEIKIDSDFLNWLANQVEIRQ SSNLQEWANEFQEMVQNKSIDELHTRTFFDTLYNLKKIKSDITINKGFLNWLAQQCKARQ SSNLQEWASEFQEMVQNKDIDELHTRTFFDTLYNLKKTKNDIIINKVFLNWLAQQCEARQ SSNLQEWADEFQKMIQNKSIDELHTRTFFDTLYNLKKIKNDMTINRGFLNWLAQQCDERQ SPNLQEWANEFQEMVQNKSIDELHTRTFFDTLYNLKKTKNDITINKGFLNWLAQQCEARQ ------------------------------------------------------------ STDVQRWTTELSKAIQSKHLDDFHVRELFHGLYALKKEGRAVKTYPTFLGWLAEETEARK SKNVQKWFNEFATLIQDNEIDELHLREFFHSMYNIKEKGKSVKVDPTFLNWLSLQSENRQ QDPESQVSKFIQNSFVGNKLDEKNFKSYFDQLVNLHQSNKSLRPSGDFLNWLAEEVESRK PQEIQQWIDHFSSAIQTEDVDELHIRNFFNSLYNIKQQGKSVKVGSSFLNWLNKEASERE ADPKSQYSHFLQHLLADSGVASEQFKLYFNKLSEVHSQDKSLKPSKAFMEWLSKEAELR- QDPESQVSKFIQNSFVGNKLDEKNFKPYFDQLVSLHELNKSLRPSGDFLSWLAEEAESRK DDPSSNVSNFIQHALVENKVSTQEFEKYFDNLVTIHQQDETLKPTREFLNWLAREVEVRK QDPESRVSKFIQNSFVGNKLDQDNFKQYFNQLAKLHQDNKDLKPTNEFIEWLAKEAELRK PKPQERVSEMLQTLVPASQSEE-QLQNMFKSLVELHR-NHDLRPSKQFLQWLSKETEMR- NNADLQISRFLQESLSSNEITSPQFRTYFDNLVTLHERNKELKPTSDFLKWLATEVETRK ------------------------------------------------------------ STNIQNWVDEIAQAIQDSTIDEFHVRKFFTTLVNIKYNKKDIKTDNNFLNWLAVQSANRK EDELKEWSGVFQRSLPSK-LSSKVKSKVYTSLAAIRRNRESVDVSEEFLEWL-------- HNLDNDLKVRDLEQEEFDQRLVDSRHSVFGNPMAARMKDPVDEL--------MPSTAIDF EKSKDDIYKRDVDQLEFDNQLAKSRHAVFGNPNAARLKERADEL------------MEKL SNLENGLQERDVEQDSFDKKLIDSRHLIFGNPMAHRIKNFRDEL---------MNNVEDF KRLNNNLKPRDVDQDAFDEKLIESRHLIFGNPLAHGIKSFRDEL------MVPNKMEPDF SNLDNGLQERDTEQDSFDKKLIDSRHLIFGNPMAHRIKNFRDEL--MKEELSKVSSMQNF ASLDSGLRERDVEQDSFDKKLIDSRHLIFGNPMAHRIKNFRDELFFKSEKRTNMNSVHDF SHLDNGLRERDIEQDSFDKKLIDSRHLIFGNPMAHRIKNFNDEL---------------- SNLDNGLQDRDTEQDSFDKKLIDSRHLIFGNPMAHRIKNFRDEL---------------- ------------------------------------------------------------ QRMTQDKQPRDLEQMEFDRLLIESRHMVFGNPMAHRIKNMYDEL-----------METEE QSLRNKRQERDLEKDEFDEKLIESRHLVFGNPMAYRVKHFDDEL-----------METES ENKKRDDYSQE--DKDFDEYMLRARHEVFGNPMGLR-KAIADELPNSHYLSNLNNLNGTN LNTQNGVHERDLDQSAFDRKLIESRHLVFGNPMAHRIKRFEDEL------------MARP ---SKGNKERDEEDRQFDQDLLRARHVVFGNPMGLR-KALADELPNSHKLSNIDNLNMTN ENKKRNDYSQE--DQEFDEYMLRARHEVFGNPMGLR-KAIADEL---------------- EKKKRDDVSLE--ELKFDEEMLHARHEVFGNPMGLR-KAIADEL---------------- ENKKRDDYSQD--DKNFDEFMLTARHEIFGNPMGLR-KAIADELPNSHYLSNLNNLNGTN ---KNTKNVRDKTDADFDTFMLEARHLVFGNPNALR-KA--DEFPNAHYLANLNNLNLTN SYKKREDYPQQ--EKDYDEKMLHARHVVFGNPLGLR-KAIADELPNSHYLSNLNNPHGTN --------------------------------------------PNSHYLANINTLNGTN SELNNGLKQRDLEQDTFDQMLVDSRHLIFGNPMAHNMKHLDDEL---------MAQVTDF ---DHPKKAAAEIGDDLVKLIKQDRGELWGNAKARKYDA-RDEL----------MSLTRL DQIQHQRLPTLYEVFILKTEPPVDLWSFYTYLSQFPYAINYLDFWIDLMAHIRLCKDYVS PNSQRARLPTLYEVLNQQTAAPLDLWSFYTYLSQYPHAIVYLDFWTDVMAYLRLCKDYVK EKIQYERLPTLYEVLIQRTSRPVDLWTFYTFLSQFPYAINYLDFWVDLMAHTRLCQSYVK EKIQTERLPTLYEVLVQKTRAPVDLWSFYTFLSQFPYAINYLDFWMDLMTHLRLCKDYVD EMIQRERLPTLYEVLIQRTSQPVDLWTFYTFLSQFPYAINYLDFWVDLMTHTRLCKNYIE EELQRVRLPTLYEVLIQRTSQPVDLWTFYTFLSQFPYAINYLDFWIDLMAHTRLCQSYVE ------------------------------------------------------------ -------------MAMLRTSQPVDLWTFYTFLSQFPYAINYLDFWVDLMAHTRLCKSYVE ------------------------------------------------------------ WRLQSERLPTLFEVLNNQTAAPVDSWSFYTFLFQYPGALNYMDFWVDVMAHLRLCKDYVK TKLQSDRLPTLYEVLNQQTTTPVDLWSFYTYLSQFPHAINYLDFWIDIMAHLRLCKDYVK QSIHLNRLPTLGEILANKSKSPVDLFTFYQFMKDVEGKIDYLDFWFDLINHLNLCKHYVK PSEALSRLPTLFEVLNRQSAAPVDLWSFYIFLSQYPYAINFLDFWIDVMAHLRLCKDYVK QSVQRNRLPTLGEILANKTKPPVSLHNFYDYMKVTDHNSDYLDFWFDLVNHLNLCKHYIW -------------------------------MKDVEGKIDYLDFWFDLINHLNLCKHYVK ------------------------------------------------------------ QSIHLNRLPTLGEILANKSKSPVDLFTFYQFMKDVEGKVDYLDFWFDLINHLNLCKHYVK NSTQLGRLPTLGEILSNKTKSPINLYTFYLYMKHVEDSQDYLDFWFDLINHLNLCKHYVR QTVQLDRLPTLGEILANKTKSPVDISTFYQFMRDVENKLDYLDFWFEMINHLSLCRHYVK QAISLNRLPTLGEILANRTKTPVDLFTFYLFMRDVEYKVDYLDFWFDLVNHLNLCKHYVK DRIQQERLPTLYEVLIQKTDSPVDLWSFYTFLSQFPHALNYLEFWIDLMSHIRLCKDYIR PQDERKRLPTLFEVLNRKSLAPVDLWSFYVYTRDQHRGVDYLDFWLDVVQHLSLCRHYIR TVRQSVVQGSALEEFRNLDEHMNNDEDASVTTSILMNT--LLSEGYLDFENPEKVSQFLQ GIRESVLDVNKLETPTVLQEGNGDDKRESVSSAMLLEA--LMNDGYLDYNDSQRVSQFLK MVRKSLAN------------FPQEHQQKGDGSATTFNLLDLIEEGHLNLQSPENLLQNEP GIRESLVVNNERQGNSSLLNEADADDSASVRTSVLLNA--LLEEGHFDLTNPAGVSQLLQ LVRKSLIN------------FPQEQQQNGSTSTATFDLLNLIEEGHLDPEAPDKLLENSG LVRKSLVN------------YPQEQQENGGASVKTHDLLSLVEEGHLDPETPEKLLQNSG ------------------------------------------------------------ LVRKSLIN------------FPQEQEENGGTSTTTFDLVNLIEEGHLDLETPDKILENGS ------------------------------------------------------------ GIRESMMLLEVEEQQGRSRGRPAGSTEKSLSSSVLLDA--LLNDGYLDYHDNRRISQFLK GIRESVLVWEEANRPPRIPKDSGVSDNYSVSTSLLLEA--LMNDGVLDFQDSKRVSQFLQ GLRDSIIRQSSTFHQQQQQSMAVSEKSNSLSSSILLDL--IINDNILEENDSHRLSAFLR GIRESVIEWEDSLERS----GANRDSRDSLSSSLLLEA--LMNDGYLDYEDSKRVSRFLQ GLRESIVRQSYNGNRHS---MPILDRSKSVSSSILLDL--IVNDNFLQGNDSRRLSQFLR GLRDSIIRQSSTFHQQQQQQMAISEKSNSLSSSILLDL--IINDNILEENDSHRLSAFLR ------------------------------------------------------------ GLRDSIIRQSSTFQHNQTATQPLSDRSKSLSSSILLDL--IINDNILEENDSHRLSAFLR GLRDSIIRHSGNGQHRSSLAYPLSEKSKSLSSSMLLDM--IINDQILEDNDSNRLSEFLR GLRDSIMRQSTYTEKRASQPLPALESKHSLSSSILLDL--IASDNFLEDNDSHRLSQFLR GLRDSIVRHSYPDQRNS---IPISEKSKSLSSSILLDL--IINDHILEDNDSNRLSQFLR GIRESVLIPNEELKSRRQSEKENNGDQDSVTSSILIDA--LMDEGYLDFQNPQKVNRFLQ GLRQSILASEHTNLSISNI-TGQGLAEQSRESSILLET--LIHDHNLLEDGDHRLSEYLR GNTHTSPMVTRMIQDWKLHNERNSVAAT-SHLQSTQAGIDISRKESMQSVSAIVDEFLKR GETDS-PRLSQLLQDWKQVNND------------------------QIDFSDFVDGLVKS SDVPFSPKLNEMLGNWKHHSGISQDALQ------------------NEDMALILDEILKR GQVNHSPKLAQLIDDWNRHSQNVDDSNR-------NRSSNNNSNSNNNNLSSILDDILKR PDVPFSPKLNELLGDWKHQSGIGQEALR------------------NEDVALIVDEIMKR PDLPFSPKLNQLLEGWKRQSGISEDSLR------------------NEDMTLIVDEILKR ------------------------------------------------------------ TDLPFSPKLNQLLGDWKRQSGISQKVLR------------------SEDMALIVDEIMKR ------------------------------------------------------------ GDGES-ARLSQLFEG--RGGDSSGEKAP--------------TEEPHLSL--MLDEFLVR GQTDS-PRLSQLMENWKRQSALEDNDRL----------------------TEVLDDFLKQ GDINLDPKLKDLIEQYNAEIEPNSKHSSQDRKTSS-HSLLLHDDDENNHSPSLLEKLIKD GHTDS-PRLTRLLDNWQKHADQDSAGAP-----------------FKSPLTGLVDDFLKT GDLEVNPRLSELISIYDNNAGQTEQTGHADKSQVFSQPKYMPLEQPPRKRPSTIEKLINN GDINLDPKLKDLIEQYNAEAESNSKHSSQDRKTSSHSLLVHDEDDENNHSPSLLEKLIKD ------------------------------------------------------------ GDINLDPKLKDLIEQYNAEIEANSKHSSPQQTTQS-QDRHSSSHSYLDDAPNLLERLIKD GDINLNPKLKELINSYDADEPVVDNSFPEKRISSNSLLDDSPDSAGNKGSPSFVERLLQD GDINMDPKLRDLIQHYNDETNPDETNVSTTPNLSKKYSADMITQSPNPPFPSLLERLIKE GDINIDPKLQDLINQYNREEGGTSNAYSEKEKPSNYANRSLHDLTPPTPSPSLLERLIKH GDLEYSPQLSQLLDDWKRHSGYIDHSND----------DSYASSGKDNKIVSAVDGLLQN GENLLSSSAASRLSALLRESQISDDHAPSRASMTHSQTPQPQSALPQQPQPLTLEIIEKL QS-QLGEKGNITTKQLYNNAQQICNTYLMSQQHSPRYLANIPDDLKNQVIHNFKANRRHD NV-TKDHKPKLTTKQLISSAQDIVSTYLLSQEQSDRFLFEIPAYLRNDTIRLIMEEKRHD RS-QQDGVPQITTKQLLHSAMGLCTTYLVSPEQSERYLSNIPAETRTRILEDIQVDRKYD QS-QLEEKPKVTTKQLLNSALKICSLYLLSPEQSERYLTNIPDEVRLKAVNLIQRNSRHD RS-QQDGKPQITTKQLLHSAVGLCNTYLVSPEQSERYLSNIPMETRNRIIESVQIERKYD RS-QQDGVPQITTKQLLHSAMGLCTTYLASSEQRERYLSNIPTETRNRIVKDVQVKRRYD ------------------------------------------------------------ RS-QQDGKPQITTKQLLHSAVGLCNTYLVSPEQSERYMSNIPTETRNRIIENIQVERRYD ------------------------------------------------------------ QM-KESQRPKLTTKQLVASANTIVDRYLVSKDRSERLLTTVPEHMRLEVINLVKGEQRYD EM-KESQQPRITTKQLLNNALQIVNMYLSSPQQSPKFLVNVPEKIRLDAIHTVQVQQRHD SP-ASNGTHFITRENLRESSHQLLLKYFVE--DSEKNL-NLPSNLNSQIIKAIEVDGRDD QA-HDFHKARITSKELLNNAQNIVNTYLLSPETSVRYLINLPDHMRENTLRMVRDEKRHD SPGMSERSSFITRDNLKESSKNLLLKYFVE--DSEKDL-NLPGSLKNDIVRAIEVEGRDD SP-ASNGTHFITRENLRESSHQLLLKYFVE--DSEKNL-NLPSNLNSQIIKAIEVDGRDD ------------------------------------------------------------ SPASDNGGRFITRNNLRESSHQLLLKYFVE--DSEKNL-NLPSNINSHIIKAIEVDGRDD TT-AGSMNSFISRQNLRESSHNLLLKYFVE--DSEKNL-NLPEKLNRFIINSIEVDGRDD SPGSTNPNSFITRDRLRESSHNLLLKYFVE--DSEKNL-NLPSSLNSQIIKAIEVEGRDD SP-GGSETNFITRDNLKESTHSLLLKYFVE--DSEKNL-NLPPSLNQKIIRAIEVEGRDD YTKMHQERPQVTAKLLLQNAQTICSLYLISPEKSEKYLINVPEHIRNETLQLVEIGGRHD FPMSDVNSPFITRERIRESSQQILVTYFMP--GAEREL-ALPAPLMESVRTAIEQQGRDD PEVFRELKEVTYQFLETDCFPKFLKEVALHNIHDELSDWRSWSPFSTYTSLSRVLFGCMW PEVFEPIKEIVYQFLEVDCFPRFLGCVALHNLHDEIVLQRSNSPFSQWSTASRLTIGLAW VAIFDDVKALTYQFLEMDCFPKFLSRVALHNIHDEISDWRSRSPFSNHTSISRIGLGLLW PEVFDELKSVSYQFLEIDCFPKFLSTVALHNIHDEISDWRSKSPFSTYTTLSRIMFGLLW IEIFDDLKNLTYQFLEMDCFPKFLSRVALHNIHDEISDWRSRSPFSNHTSISRIGFGLLW IEVFDDVKNLAYQFLEMDCFPKFLSRVALHNIHDEISDWRSRSPFSNHTSISRIGFGLLW ------------------------------------------------------------ IEIFDDVKNLTYQFLEMDCFPKFLSRVALHNIHDEISDWRSRSPFSNHTSISRIGLGLLW ------------------------------------------------------------ PDVFEPLKIISFQFLEIYCFPKFLSSVALHNLHYDISLSQSRSPYSQCTTLARVATGFFF PDVFESLKSVAFQFLEMDCFPKFLGCVALHNLHDDMTDHSKSSLFSTYTILSRVFLGLLL PDVFNYVKNFVFNKLENEHLPKFLDFMATRNI--------------NHSNFWRIILGFFF PELFEQLKSLAFQFLEMDCFPKFLTSVALHNLHDDITTPPRHSPFAHHTTLSRVALGMLF PDAFSNVKIYVFNRLENYYLPNFLDLVAIKNI--------NRTSNNFLVSYGRIILGFFF PDVFNYVKNFVFNKLENEHLPKFLDFMATRNI--------------NHSNFWRIILGFFF ------------------------------------------------------------ PDVFNYVKNYVFNRLENDYLPKFLDFMATRNV--------------NHSNFWRIIFGFFF PDVFNGVKKFIFNRLENEHLPNFLNFVAIKNV--------------NHTINIRVIVGFFF PDVFINVKNYVFNRIENEHLPRFLNFVAIRNI--------------NHSNFIRIILGFFF PDIFNEVKAYVFNRIESEHLPRFLNYMAIRNV--------------NTSFITRVILGFFM PEVFESMRSLAYQFLEIDCFSKFLNRVALHNIHDQISDWKSRSPFSNYTTISRICFGTFW PEVFDECREYVFQILEREVFPGFLATKALGNL-------------VPLGALVRMVAGLVA MGIGFWIGYVLIFLHYSRAIRVTTVVPFGLGCYYIVCGIYQVDIIYSWFGLTQRLMYSHK WLVGLWIGYTLIFMNYSKGIRVVCIVPFFLGSYYIICGIYLVDIIYAFSGVTQTLVSKRK LGIGFWIGYVLIFLAYGRAIRVVTVVPFALGCYCVVCGMYQVDIVYSWFGVTQRLLHRHK LGVGFWIGYTLIFLKYDRGIRVVTIVPFCIGSYFVVCGLYQVDILYSWFGITQRLLYKDR LGIGFWIGYVLIFLAYSRAIRVVTVVPFTLGCYCIVCGMYQVDIVYSWFGVTQRLLHRHK LGIGFWIGYVLIFLAYSRAIRVVTVVPFALGCYCIVCGMYQVDIVYSWFGVTQRLLHRHK ------------------------------------------------------------ LGIGFWIGYVLIFLAYSRAIRVVTVVPFTLGCYCIVCGMYQVDIVYSWFGVTQRLLHRHK ------------------------------------------------------------ WAVGFWVGYSLIFLDYPRRVRTVTLVPFLIGSYYIVCGVYHLDIIYAVCGVTQTLISPRR LGIGFWIGYVLIFLDYSRGIRVVTIVPFFLGFYYVVCGIYQLDVVYALFGVTQNLVTNKD LFIGFWVSFIMVFLNYRKGLRPVIIIPYFLAFYFLISSIYLIDPVMAWMGISETFSKSNG LWMGLWLGYTLIFLDYSRGIRVTTIVPFFLGFYFICCGIYRIDILYALAGVTQTLVSNEQ LFIGFWMSYIFLFLNYSKGKRLYIIIPFIISAYCLISSIYFIDPILVWLGYSESFTSENY LFIGFWVSFIMVFLNYRKGLRPVIIIPYFLAFYFLISSIYLIDPVMAWMGISETFSKSNG ------------------------------------------------------------ LFIGFWVSFILVFLNYRKGLRPVIVVPYLFAFYFLVSSIYLIDPIMAWLGLSETFSKSNG AFISFWIAFSLIFLKEPKRYRAVIVFTFFVAFYNLVSAAYRIDPFLALCRRSESFIPGMT LFGGFWISYIFVFLNYRKSIRPIIVAPYLLAFYFLISSIYLIDPVLAWFGYSESFSRASG LLIGFWVGFIFIFLNYRKSLRPVVLVPFLIGFYCLVSSVYLIDPILVWFGLSESFSSKQS MGIGFWIGYVLIFLNYNRGIRVVTIVPFAIGSYFIVCGIYQVDVVYSWFGVTQELMFRHK VFGAVWTGFCLIFLNYSRTERVWVLLPFAIGWYLVIAGLFSLDPIQAVLGFSESSLTK-- KGNIEEGQVTYNDDVPLIFTLLGGKSRLIHIEHPFIKKILYKRGLWCLTLVVIFTAIFTV LDDLELSNNHSSNEVPWWLTIFGGRSRLCKVKHPFVNSIMIRRALWCLLLVLIMTAILTA NSNDDAGAATDADHVPGVLAVFGGKSRLTSVQHPFTRRLLRKRGWWCLLLVAGATAVLTV KVTEDGYGNESKDKIPFIFGILGGRNRLIEVKHPFIRKFLFQRGLWCCLLVLISTGVFTV NAGNDEGASSDTDHVPMILAVFGGRRRLTRIEHPFTRQLLRKRGLWCLLLVVGATAAFTV DGSDNEDSSEDFDHVPAILAVFGGKSRLTCVQHPFIRQLLRKRGLWCLLLVVGATAAFTV ------------------------------------------------------------ NTNSDEDASTSPYHVPALLAVFGGKRRLTRIDHPFTRQLLRKRGLWCLLLVVGATAAFTV ------------------------------------------------------------ YEEPELGDQNSATKVPFFFTFLGGRKRLTKVRHPFVLNIMRKRALWCLFLVIVTTAVLTV KRDLELGQRSNVRRLPVIFRVLGGRGRLVKVRHPFVDRILKRRSVWCWFLILLGTAIFTV R-------------------------SLMKIREKFIYRFIVKRSLWVLFLVLIFTAIFTV VKDLEIGNRRMSHNAPFVFRILGGTGRLVRIKHPFINKLLKKRGYWCLLLVLTLTGVFTV ---------------------------LIKIKEKFIHRLLIKRSLWVTALILLFTAVFTV R-------------------------LIMKIREKFIYRFIVKRSLWVLFLVLIFTAIFTV ------------------------------------------------------------ R-------------------------SIMKIREKFIYRFIVKRSIWVLFLILIFTAIFTV ---------------------------FIKLEDSFIHRLLLKRSTFVVILILLATAIFSV L-------------------------PLIKIRENFIYKLVFKRSLWVLFLILLCTAILTV Y--------------------------FIRIRENFIRRLLVKRSAWVMFLVLLLTAIFTI SSDEENGPMKNNKGVPGILKVLGGKSRLIRIDHQFIRNLLFKRGLWCCAIITISTAIFTV ---------------------------RVRIKEPFVRRLLLIRSSWVMLWVVIVTACFTV IFCCVPGRRLNSHMAPWVPMFTQSCKNAKQAPFQFATVAESDLPKCRTVVFRDFLFDERK IFAAVPGRRI-------------------------------------------------- IFSCVPGRRV---------MFIQSCKNNTEPPFQFATVDKLNKPRCRTVVFRDFLFHDKK VFSCVPGHRVHSQMAPWVPTFIQSCKNNEQPPLQFATIDNANLPRVRTVVFRDFLFHDKK IFSCVPGRRVSHQMAPWIPMFIQSCKNNTEPSFQFATVDELNKPRCRTVVFRDFLFHDKR IFSCVPGRRVSHQMAPWVPMFIQSCKNNTEPLFQFATVDKLNKPRCRTVVFRDFLFHEKK ----------SHQMAPWVPMFIQSCKNNTEPSFQFATVDKLNKPRCRTVVFRDFLFHDKK IFSCVPGRRVSHQMAPWVPMFIQSCKNNTEPSFQFATVDKLNKPRCRTVVFRDFLFHDKR ------------------------------------------------------------ IFTAVPSVRLIHQMAPWVPIFVQSVKNHPQPPFSFSTVDPDLRPRCRTVVFRDFLFHDRK IFSCVPGHRLIHQMAPWVPHFLQSLKNHTQPPFTFGTVDPVSKPRCRTVIFRDFLFHDKR LFSLVPGHRLQHFQSPWVAPFDESVKKNDPPSFQLATIDSEGYPQNRTLVYRGWLFDNKD IFSCVPGRRLIHQMAPWVPQFIQSWKNESQKPFYFATLDPQNQPKCRTVIFRDFLFHDKR LFSLVPGHRLFQYMAPWIPTFKSATEENDPPTFQFATVDSQGFPHVRTLVYRGFLFDDRN LFSLVPGHRLQHFQPPWVAPFDESVKKNDPPSFQLATIDSEGYPQNRTMVYRGWLFDNKE ----------FNYQAPWVPVLNNCIDDNKPPTFQIATIDSKGYPNSRTVIFRGWLFNNKS LFSLVPGHRL-----MWQYALQQCIKDNNPPTFQLATIDSKGYPSNRTVVYRGWLFDNIE IFCLVPGHRLFHYMAPWIPCFTSAIEDHKPPSFQFASVDTDGFPHNRTVVFRGFLFDNKS VFSLVPGVRLFHYMAPWVPGFTHAVEENKPPPFQLATIDSKGFPKNRTLVYRGFLFDDKS IFSLVPGKRLFHNMASWVPPFTNSIDGNSPPAFQLATIGNDGYPRTRTLIFRGFLFNDRN IFSCVPGRRVIHQMAPWVPTFIQACKNNSQPPFQLATVDKIGKPRCRTVVFRDFLFKDKN IFACVPGHRLMSNLPSWVPEFERVFNKHEGP-FTLATVDQQ-RPRARTCVCRGWLFNSRN TNVLTFNTDLRSNKVEESFGTCLFEACFYFHETWEQYRFTGECFLVSRKQLPAMVDSLKL ------------------------------------------------------------ TNVLTFNTDMRSSKITESFETPFFEVCVYFPETWEQYRFSGQSFILSRQFNDADDHNINN TNVLTFNSDLRSGKIDESFHTTTFETCVYFPQTWEQYRFSGQCFVISNKSNEEAGEYVHD TNVLTFNTDMRSSKITESFETPFFEACFYFPETWEQYRFSGQCFTISKQFNDADNNDINE TNVLTFNTDMRSSKITESYETPFFEACVYFPETWEQYRFSGQSFTLSRQFNDADNNDMND TNVLTFNTDMRSSKITESFETPFFEACVYFPETWEQYRFSGQSFTISRQFDNDKNNDIND TNVLTFNTDMRSSKITESFETPFFEACVYFPETWEQYRFSGQCFTISRQFNDADNNDINE ------------------------------------------------------------ TNILTFTTDLRGEKVKEIGTLAPFEGCFYFPQTGEQYRISGSCFVLSEGQADVREDHSAA SNVLTFTTDLRGEKVHEITQTAPFEACFYFPDTWEQYRFSGECFVISNKKTFSDEENVSP SSVLTFATDKRMSKYKELLHNDKCEAVFYFSRIKKQFRLRARARVIDEQNPPLDLINVLN SNVLTFTTDMRGDKVKEILETAPFEACFYFPGSWEQYRFSGKCFVVSRQKGAAEPRTARP SNVITCVTDKRTNKYKELLTNDKFEAVFYFPKIRKQFRFRGMARIIDNTYHSLLSPSLLS SSVITFTTDKRMSKYKELLHNDKCEAVFYFSRIKKQFRLRGRARIIDEQNPPLDLINVLN SNVITFTTDKRMDKYQELLQNDKVEAVFWFSNIRKQIRFRGRARILDDEHTPLLSPTYAA TSVITFTTDKRMQKYNELLQNDKFEAVFYFGHLKKQFRLRGRAQIIDEEHADLAQSFIPR NNVLTFCTDKRMGKYEELLHNDKFEAVFYFEKVKKQFRFRGRAKIIDDNHFPIISPSLLS NSTLTFTTDKRMDKYDELLHNDRFEAVFYFGRTKKQFRFSGRARIIDDAHLDLLSPSLLS TNVLIATTDKRMSKYSELLHNDRFEAVFYFAGIKRQFRFRGHAKIIDDDHSRMLPYTVLS SNILTFNTDIRSDKIKESIGSTDFEACFYFHQTWEQFRFSGDCFILSQNEYFEDNDVMID TGVLLFTTDRRMDKTSQLAENDAFEAVFYSEAHHAQFRIQGFAKLLSDDMKPDDFEAVKS DDSKYDNPTDEEWQQEIMRQWDTLSRATKSVYKKPAPGEPITEEMKKKIDIERGVDGSKA ------------------------------------------------------------ DNKLIETPQPQEWDAELLRQWSSLSRHTKSLYRKPAPGQKLTSETSKQLDLHRGVDGAKE EEEDFCCPDDEDWDNEVIRQWSSLSRSSKSLYRKPAPGSPLTKETSKALDIQRGVDGAKE DNKLIESPQPQEWEAELLRQWSSLSRHTKSLYRKPAPGQKLTSETSKQLDLHRGVDGAKE ENKLIETPQSQEWEAELLRQWTSLSRHTKSLYRKPAPGQKLTSETSKQLDLHRGVDGAKE DNKLIEIPKPEEWEAELLRQWSSLSRHTKSLYRKPAPGQKLTSETSKQLDLHRGVDGAKE DNKLIEIPQPQEWEAELLRQWSSLSRHTKSLYRKPAPGQKLTSETSKQLDLHRGVDGAKE ------------------------------------------------------------ QLSRISTPSAREWKLELSRQWGQLSRNMKSQFRRPHPGTPLTTTMAQKLDIQRGVDGAGE QLSRMSTPMSREWNMELMRQWVSLSRSTKSQYRKPDPGTPMTSETSSKLDIQRGVDGGKE QEEETERQISTDITQELNRQWSNLSKSLKKSFKKPPPKSVMSDENAKLISIHRGVDGKNI NLSRSSTPLAKEWDLELARQWANLSRSTKAQFRKPDPGTPVTSETSKQLDIQRGVDGAKE QVQKQKSPTEQEWETEHKRLWFNLSKPLKKSFRKPTPTTPINNENQKLIDINRGVDGKKD QEEETEHQISTDITQELNRQWSNLSKSLKKSFKKPTPKLIMSDENAKLISIHRGVDGKNI NNTAQEEPTDEEWDQELQRYWDGLSKPMKTSFRKPAPKSPMTEENQKLISIQRGVDGKKS NNSFDNLPSGDQWKDEIQRQWDSLSKHLKKSFIKPPPKEDLNGTNAKLISIHRGVDGKHE NIQQENSPTKEEWDGEIARVWNSLSKGLKSSFRRPAPMSPVTDENHNLMDISRGVDGKKE QFNNDSTPTDQEWSDEIERQWNGLSKGLKKSFRKPLPLTPLTDEHVKLMDINRGVDGKKD PSAVRSQPTRQEWNQEVRRQWDALSPALRSTFRKPPPGSEITDENRRVIDIRRGVDGKKE STEVLSDATNKDWNLEIKRQWSLLSRSTRSQYRKPQPGEPITTETSKKLDIQRGVDGTKE RLGNMSDPSSEEWNKEYHRVWDSLSPTTKSSFRKPQPRSLMSDDKKKQLDFARGVDGEHE DYGLDNFAIVCLCIDKVDYLNLKGGKRWIFERDETWEEQEVCPMSPTQLEIKVKALQRLV -------------------------------------------MAPTQLEIKERALKRLC DVGLENFGIICLCIDTVDYLNLKEGRRWIFQKDGKWEEQEVCPMAPTQLEIKVKALKRLV DAGLENFGIVCLCIDTVDYLNLKDGRRWIYRRDGTWDEQEVCPMAPTQLDIKCKALERLV DAGLENFGIVCLCVDSVDFLNLKEGRRWIFQKDGKWEEQEVCPMAPTQLDIKVKALKRLT DAGLENFGIVCLCVDSVDYLNLKEGRRWLFQKDSKWEEQEVCPMAPTQLDIKIKALKRLT DVGLENFGIVCLCVESVDFLNLKEGRRWVFQKDGKWEEQEVCPMAPTQLEIKVKALKRLT DAGLENFGIVCLCVESVDFLNLKEGRRWIFQKDGKWEEQEVCPMAPTQLDIKVKALKRLT ------------------------------------------------------------ DTGRENFGLVCLCVDQVDYLNLKNGSRWRFIREITWQEQEICPMAPTQLEIKVRALQRLI NTGLENFGVVCLCVDQVDYLNLKDGKRWMFRREETWEEEEVCPMAPTQLEIKVRALQRLV DYGLKNFALVGLFIDYVDYYDLEKDKRFIYQLDENWFEQEVCPMGPSPLQIKVNALKRLI NTGFDNFGVVCLCIDKVDFLTLKDGRRWKFHRPETWVEEEVCPMAPTQLEIKVRSLQRLV EDGLKNFAVVGLFIDYVDLYELDKDRRYIYAKDSTWSEAEVCPMSPSSLQIKVNSLKRLI DYGLKNFALVGLFIDYVDYYDLEKDKRYIYQLDENWFEQEVCPMGPSPLQIKVNALKRLI DDGLKNFAVVGIFVNYVDYFEQDKDKRFIYELEEEWTETEVCP-MPSQLQIKTNALKRLI DYGIKNFAVIGLFVEYVDYCDLDKDRRYIYQLDENWNEHEVCPMAPSPLQIKVNALKRLI ESGMKNFAVVAMFIDQVDYYEMEKERRYIYVKDDTWSEQEVCPMSPTPLEIKTKAVQRLL DHGKKNFAVVAMFIDRVDLVELDKDRRYIYVKDPHWSEEEVCP----------------- DSGLKNFAVIAMFVDKVDVVELDRDRRYVCERDGMWVETEICPMAPTKLEIKVNVVKRLL NAGLENFAVVCLCIEEVDYLNLKGPSRWKYKRDGQWEEKEVCPMAPTQLEIKVKALQRLV D--LSNFVVVLLCPNRVDFCTVDGA-RNIFTRLGEWREQEVCP-MPSQIKIKTSALGRLI KEEKYYLQELKDQKKHVDELKADSSDKYDLKKQEEVLADTERLLPTLYVKIKEFQDNLEE KEEHFYQEELEQQKLHVKKLQSDPSDPYDLKKQVEVQQDTERLLPELYKKIKQFRDDLDK KEEGYYQQELKDQEAHVAKLKEDKSDSYDLKKQEEVLDDTKRLLPTLYEKIKEFKEDLKQ KEESYYQQELKEQQQHVDTLKKDTKDPYDLKKQVEVLEDTERLLPTLYAKIREFKENLQQ KEEGYYQQELKDQEAHVAKLKEDKSDPYDLKKQEEVLDDTKRLLPTLYEKIREFKEDLEQ KEEGYYQQELKDQEAHVAKLKEDKLDPYDLKKQEEVLDDTKRLLPTLYKKIGEFKEDLAQ KEEGYYQQELKDREANVAKLKEDESDPYDLKKQEEVLDDTKRLLPTLFEKIKEFKEDLEK KEEGYYQQELKDQEAHVAKLKEDKSDPYDLKKQEEVLDDTKRLLPTLYEKIRQFKEDLEQ ------------------------------------------------------------ KEEKYYQDELREQRERVELLKRDASDPYELKKQIEVMQDTERLLPRFYEKVQQFYNDLKD KEETYYQQELKEQQQHIEKLKEDPSDPYDLKKQVEVLQDTEKLLPALYQKIGDFKENLEQ KEEKLSKQEVAEQEQHINQMKANNADEYELKKQIQVLEESQRMVPEVTKKVAEYRQALKE KEERYYQQELADQKTHVQGMKNDPEDSYDLKKQVEVLEDTQRLLPALYEKIGQFKDDLAH KEESLYQQEVAEQQHFVNQMKSNNADEYELKKQIQVLEESQRMVPEVSEKIKKHKQALIE KEEKLCKQEVAEQEQHVNQMKANNADEYELKKQIQVLEESQRMVPEVTKKITQYRQALRE KEEKLYKQEVVEQEQYVEQMKKNQADQYEIKKQIEVLHESQRMVPQVSEKIASMKESLRE KEEKLYQQEVSEQEQFVNQMKANNADEYELKKQIEVLQEAQRMVPEVTKKIKEHKESLKE KEEQLYLKEISEQEEQLQQMRASDTDEYEIKKYEKVLDESKRMVPELKKKIQEHAKGLKS ------------------------------------------------------------ KESKLYDEEASDQEKALSDMKERHEDPYLIHKQEVLLKEAQMMITEIRKKVEDQRTNLAK KEEGFYQQELKDQTDYVEKLRKDSSDPYDLKKQIEVQQDTERLLPTLYKKIGEFKENLEE KEEKLYKQETAEQAARVEKMKANGEDEYDIKKQIEVLKDTEQMVPVMRKKIDEMKASLEG YLNTYNGNEDTKEAKEAI-----------------------------------MKVLRFN YLSSYEGTEDLESAKAAL---------------------------------MALKLLGFN FLESYQGTEDVSEAKTVI-----------------------------------MKVLQFN YIDSYEGEEDLHEAKIAI-----------------------------------MKALNFN FLKTYQGTEDVSDARSAI-----------------------------------MKVLQFN FLETYQGTEDIGDAESAI------------------------------------------ FLETYQGTEDISDAKTAI-----------------------------------MKVLQFN FLKTYQGTEDVGDAKSAI-----------------------------------MKVLQFN ------------------------------------------------------------ FVNGYNGDEDTADAHNAL-----------------------------------MKVLRFN YLESYQGTDDLTGAREAV-----------------------------------MKVLRFN FLDSYKGDEDVTEAKELL--------------------------------MVTINDLSFN FSDNYSGSEDLSSAKAVL-----------------------------------MRALRFN YVENYKGDEDLSAAKELI--------------------------------MVIINNLTFN FLDSYKGDEDVTEAKELL--------------------------------MATINDLSFN FLNEYTGEEDVSEAKGLL----------------------------------MINDLSFN FLETYTGEEDTSAAKELL--------------------------------MITINDLSFN YIEDYKGDEDTSDSKALLVISYNPFPQIANASNSSKLPLWTHLQRKHKSRKMGINDLSFN --------------------------------------------------MTTINDLTFN YLDNYDGDEDTSEARALI----------------------------------MINDLCFN YLKTYQGNESLDDANKII-----------------------------------MGLSRFN ILVSMRGGRLGGKVTPPL------------------------------------------ QDASCCVVNSGANELTVYNCDP-FGKCFEF--NINGDS-----------------NDNGI QDATCFSVISSNKGVTIYNCDP-FGKCFELTSND-------------------------- QDATCCVVAASSHQISIYNCDP-FGKCFEI--DTKNSKRKNGNSNGSRDNGDAEEEEEDN QDATCCVVTTAPHSLTIYNCDP-FGKCFEL--DT-------------RTRNNTGSNDSLD QDATCCVVAASSHQISIFNCDP-FGKCFEI--DTKNSKKKTSNTNGSRDRTDAE-EEEDN ------------------------------------------------------------ QDATCCVVAASSHQISIYNCDP-FGKCFEI--DTKNSKNRNSNSNGSRDRGDIE-DEEDS QDATCCVVAASSHQISIYNCDP-FGKCFEI--DTKNSKKKNSNSNGSRGRTDVE-EEEDN ----VVMI-------EAY-----Y------------------------------------ QDASCFSAVSRPHSMTIYNCDP-FGKCFEL--EN------------------SVVTSESC QDASCCAVAFSGSSLSIYNCDP-FGKCFEL--EN------------------GSNSSRED PDYSSISV-STSDGFKIFNCEP-FGEFYSS--QE---------SPLRKSISNSLEDSAGC QDATCCSVSHSTSSVCIYNCDP-FGKCFEL--EN---------------------GSRTS QDYSCVSV-STTKYHKIFNCDP-FGEFYSSSSGT----------KGDKPNDNDKEIIIDK PDYSSISV-STSDGFKIFNCEP-FGEFYSS--QERKSISNSLE------------DSTGS TDNSSISV-STDEGHMIFNCEP-FGRIYSS--QDKRSLSNSLDNREEHEGEQDQTRDTAT PDYSSISV-STSEGFKIFNCEP-FGEFYSS--QERRSISNSLD------------TTTTP QNFTSLSM-STDEDHRIFNCDP-FGEFYVSDKEK-------------------------- QDYSCISI-STSNYHRIFNCEP-FGQFYSSNIKK---------TLSNSIETNTVNANVDN QDATCVSV-ATSTGYSIYNCDP-FGEFYSS--KG----------SARGPKNSSSTSNDHD QDATCFVTSSEGNSVTIYNCDP-FGKCFEMDTQN------------------------IG ------------------------------------------------------------ GYDSLEAGSSSIESQVIAEMLFSTSLLAVVDKG-QGINTGKKLKIVNIKKRSLICEIAFP -----------EELDFLVEMLFSTSLIAVVDKT-IGASKRKKLKIVNTKRKATICELTFP DDNALVSGNILKEGEFVIEMLFSTSLIAIADRG-QGLNKGKKLKIVNTKRKSTICEIVFP GTALDASVANEEDNGIIVQMLFSTSLVAIADRN-QGVKKGKKLKIVNTKRKSTICEIVFP EDNALVTGNILKEGEFVIEMLFSTSLIAIADRG-QGLNKGKKLKIVNTKRKCTICEIVFP ------------------------------------------------------------ EDNALVTGNILKEGEFVIEMLFSTSLIAIADRG-QGLNKGKKLKIVNTKRKSTICEIVFP EDNALVSGNILKEGEFVIEMLFSTSLIAIADRG-QGLNKGKKLKIVNTKRKSTICEIVFP ------------------------------------------------------------ DTECLTKAQGDQCSNFVTEMLFATSLIAVVNRD-QGLQKARKLRIVNTKRKTTICELTFP LRSYNAHTSSEDPPNFVIEMLFSTSLVVIVDKN-QGLQKSKKLKVVNTKRKSTICELTFP QNPTHSKTDSQDTPARFLKMLFSTSLTIVVPQT-QDNLGNRLLKIYNLKQNLKICELNFP SRDDLSGYQNPPEPDFIVEMLFSTSLIAVVDKN-KGSQKCRKLKIVNTKRKSTICELTFP GNGNEYNKIGEDSPTLYLKMLFSTSLTIIIPQ--NESVGNRLLKIYNLKQNMKICELTFP YNQIHSKNDFQDTPAKLLKMLFSTSLTIVVPQS-EDNLGSRLLKIYNLKQNLKICELNFP AKSDNNNVDQTHLPTLLLKMLFSTSLTIIVPKG----NDNCILTVYNLKQNLKIMDLKFI KGTIRNDDVSDNNATAFLKMLFSTSLTIVVPQS-QDNLGNRSLKIYNLKQHLKICDLDFP ------------CPTAFLRMLFSTSLTIIVPDT-QSSMGNRVLKVMNLKTNMKICELNFP NTRNSRASLETKCPTAYLKMLFSTSLTIIVPQS-QNKLGNRLLKIYNLKQNLKICELSFP NGVDSSSGASTSSPTASVKLLFSTSLTIIIPQS-GQPSGDRLMRIFNLKQRLKICELTFP DDDARGDDNSGGDDDLLVEMLFSTNLVAIVHRK-QGILKSKKLKIVNIKRKTIICELSFP ------------------------------------------------------------ SLIVDVVMNRKRICVLLDNDQIFIYDISCMKLMETLDLWESNNNLKNGNELDRIRSKSNN HEIMDVIMNRKIICVVLKSDQIFVYDISCMKLLRTIDVR----------GEKLKS----- HEIIDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYSANLNRTASNLLSNTTQ HEIVDVVMNRKRMCILLESDQIFIYDISCMKPMTTIDLWEDHI--KSNSMVANIA----- HEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYSANLNRVATNLLANATQ ------------------------------------------------------------ HEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYTANLNRTASNLLSNATH HEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYSANLNRAASNLLANATQ ---------------------------ALHRIVHR--------------GTISIA----- HEVVDIVMNRKRMCVLLSSDQIFIYDISCMKLLQTISVLEDKL-------KMAVSDQGHV HEIVDVVMNRKRMCILLSSDQIFIYDISCMKLLQTIDVL----------------EDKLK SSIIDIKLNRKRLLVVLDTGQLYIYDLSCVRLLKILQLSFNEH----DGDQKFIGDLSAD HEIEDVVMNRKRMCVLLASEQIFIYDISCMKLVQTIVLEGNTK------------PVQ-- SHIIDVKLNRKRLCVILESGQIYIYDLSCVRLIKVLEISSEEE----THQKLFVGDLGAE SSIIDIKLNRKRLLVVLDTGQLYIYDLSCVRLLKILQLLFNEH----NSNQKFIGDLGAD SSIVDVKLNRRRLLVMLVNGEVHIYDLSCIKLLKVLFLQKEEA----VRSGSFVGDLSVR SNIIDIKLNRKRLLVILDNGQLYIYDLSCVRLLKILQLQLNDD------CKEFIGDLSND SGIVDLMVNRKRLVVFLEVGQIYIYDLSSIRLVKVVEVNDDAM------PNPVIADLSAD SNIINIKLNRKRLLVFLEIGHIYIYDLSCVRLIKILEVNSYLNLTDSGQTARLIGDLSAD VGIVGVRLNRKRLCVLLSSGQLFIYDLGCVRLVKVLELDPDHS------FVGDLAP---- HPIQDVVMNRKRVCVLLNSDQIHIYDISCMKHLHTIDIWDSQVKSITGQGVDSLSNSGTS ------------------------------------------------------------ NNDQTNSDNGRSRTYS-----INGSHKI----KPQLTLSGNDN---------------SI ---TSKFRNSEAVGDI----------------GVRVSLSTDNN---------------SI KGPSSSNASVRSRRNS-------LRSRI----RPRMVLSNDDR---------------SI ENMRVQSDERNNTTRK-------RRNSVRSRLRPRIALSNDDR---------------SI KSVNGSNPSVRTRRNS-------LRSKI----RPRMVLSNDDR---------------SI ------------------------------------------------------------ KGVNGSNTGVRSRRNS-------LRSKI----RPRMVLSNDDR---------------SI KSVNGSNPSVRSRRNS-------LRSKI----RPRMVLSNDDR---------------SI ---FLL------------------------------------------------------ STSVVGRQLQGETSMV------------------RIALCSDDK---------------SI DVVRQALPPPSHTLPD-----------------VKLALSSDDR---------------SI DSSWLIIPVQSTNNQTDLLNAETGSQPSTPKLTPSDSVINTGS----------------- ---SSTSPTSPSVRMS---------------------LGSDDS---------------SI DKSLLVLPISNITDQTDLFNTENGVNVTRASDSNILTSLKPLI-----------EFTENK DNSWLIIPVISTSNQTDLLNAETGSQPSTPKLTPSDSVINTGS----------------- DDSWLVLPLSLVNEQILKDKGEIWEGDNESGQQTERSSKSAKH----QSKDTDSSEKDTG DKSWLILPISYTTNQT-----DLLNNENNNPSQPSTPRLKPSD------------SVVNT DSSYLILPISVLNDNSDILNADSTSSQNNSSQPGTPVLRPSDS--TVANSLDTLIELTQK DNSFLVLPLSAINDQTDLFNHEHSSASPLRKSDSTIIANSLDS--------LIEYTHKDT DDCYLVLPMSSVIKQTDLFNLTSAGTDAETKCDSTSNKSTPQL--------------ADL NMTSLRERSSTFSKSI----------------SPKICLSNDDR---------------SI ------------------------------------------------------------ LCYSKYSS--SKQNPA---RIL-----------------------NDIVVYDALNLKPIN LCYSSYSKSDKENAPL-----------------------------NDIVVFDALKCIQIN LCFTAYSSPKKNKPNS---EVL-----------------------HDVVIYDTLNVTPIN LCYTAY-SSNNNRPDS---FLL-----------------------NDIVVYDALNVKPLN LCFTAYSSPKKNKPNS---EAL-----------------------YDVVIYDTLNVTPVN ------------------------------------------------------------ LCFTAYSSPKKNKPNT---EAL-----------------------YDVVIYDTLNVTPIN LCFTAYSSPKKNKPNS---EAL-----------------------YDVVIYDTLNVTPIN ---------------------------------------------HDVVVYDTLNISPIN LCYTAYCRTNKNFIYI-----------------------------NDLVVYDALNMTPLN LCYTAYSHSTSDSYLL-----------------------------NDVVIFDALNVTPIN --YSQYLEFTRNSSLSNLKKKNKLITLEDIKNDSE----------GWVVVYDTINLAPVV LCYSTFSRTLNDTCVF-----------------------------NDIVVFDALNACPVN IDKDIITLEDLQKDSN-----------------------------GWVLIYDTIKLKPRL --YSQFIEFTRNSSLS---SLKKKNKLITLDDIKKDSE-------GWVIVYDTINLAPVV YCLQKYLAITPKNSQNKDFTAKRPITLKDLRKDGN----------GWVLVYDTIKLEPII ESYDKYIELTRKSSSS---TLHKSSTNIGLEDIKKDSE-------GWVVIYDTINLLPVL NSSSLLSSIEGITLEDLQKDSQ-----------------------GWVLVYDTLNLKPLL HHLHKKGSITLDDLKK---DSN-----------------------GWVIVYDTIELRPRL IDITSKNQSDKLKHPGLTLEEIHKDSP------------------GWIMVYDTLELRPRL LAFNCYSTSSKSVIL------------------------------NDVVIFDALNISPLN ------------------------------------------------------------ YLNSVHKGCVLKTSVSIDGKLLATASEKGTIIRIHKTGVDSDFASGPLLYKEFRRGSRPS VLPAVHQSNIVCIACSPDGMLMATASEKGTIIRVFKTIDTEN---EPILVNEFRRGSRPS YLNTVHKGNVACLAVSHDGRLLATASDKGTIIRVFHTGVDSDYTSSRSLFKEFRRGTRLC YLNTVHKGNIACLAVSHDGKLVTTASDKGTIVRVFNTGVDMQFDSSNSLVYEFRRGSRPC YLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLC ------------------------------------------------------------ YLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLC YLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLC YLNSVHKGDIVCIAISHDGKLVSTASEKGTIIRVFNTGADTDYEAGNLLMYEFRRGSRPC YLNTVHKGNVACLCISNDGKMVATASDKGTIVRIFSTGDENTLQSGNTLLHEFRRGTRPC YLNTVHKGNITCLTVNHDGKLVATASEKGTIVRVFHTGADSDFDSNDPLFHEFRRGTRPC IFEA-HHSTIARICISHRDNKVATASIKGTIIRIFDLKEFEK-------VKNLRRGHNLV YLNSVHKGCIHCLAVSHDGKLVATASERGTIIRVFHTGADSEYRTSEPLYREFRRGTRPT IYKA-HDSSLAKITISNDNKKIATASSKGTIIRVCHLESSDDEDVNISQIINLRRGHNIA IFEA-HHSAIARICISHRDNKIATASVKGTIIRVFDLK-EFEGKVKVHQVKNLRRGHNLV IFKA-HDSSIAKITISHKDRKIATASIKGTIVRVFQMEEQERGEKHRIELVKLRRGHNVS IFQA-HNSAIGRICVSPKDNKIATASVKGTIIRVFHLKDETDGNPKISMVTNLRRGHNPA VYKA-HDTAIARIAISSESKYIATASTKGTIIRVCHLNSDFK-------IAQLRRGHNVT IFKA-HNSSIGKITVSNDNSKIATASVKGTIIRVFLIDSNSK-------ISQLRRGHNLA IFKA-HDSPLAKIRVSNDGASIATASTKGTIVRVSRVAKNGDDLH----LHQLRRGHQPT YINSVHKGNVASLAISPDGKFIATASEKGTLVRIFNTGAETESELLTPLLYEFRRGNRPC ------------------------------------------------------------ HIHQLLFNKDSTLLVCVGDSDTIHIFRT-----------------------DDDGLALDG RISEMKFNHDNTLLACVGESDTIHIFAL-----------------------PVTTTEADA NLYQLVFDKSMTMIGCVGDTDTIHLFKI------------------------DEVSNSLA NLYQLIFDRKTTKIGCVGDSDTIHIFRL-----------------------------SLN NLYQLAFDKSMTMIGCVGDTDTIHLFKL------------------------DDASNSLP ------------------------------------------------------------ NLYQLAFDKSMTMIGCVGDTDTIHIFKL------------------------DEGSNSLV NLYQLAFDKSMTMIGCVGDTDTIHLFKL------------------------DDMSNSLT HLYQLTFDRHATMLGCVGDTDTIHIFDL-----------------------KHRQSESTN SIYEMKIDPTRRYLACVGHTDTIHIFDL---------------------------ERQGQ EIYGMKFDPQSSKLGVIGGTDTIHIFKL-----------------------------EKG KVNSLSFHNDNHILGCGSESNTIHLFKI-----------------------HEEESDICT SIYEMKFNLSNTLLGCVGDTDTVHIFKL------------------------PQNSNLKD KVNCLSFSLDNLILGCGSESNTIHFFRL-----------------------LKQPHESFE KVNSLSFHSDNHILGCGSESNTIHLFKI-----------------------HDEESELCA KIKSMSFSSDESILGCASESNTIHLFDL------------------------ISDGGIET RINALNFHNDNHILGCGSESNTIHLFKL-----------------------SGDGLDQHE RISTLRFNSSSTILGCASDSNTIHFFTV------------------------HENTQVGN RINTLSFNADNLILGCGSESNTIHFFRL-----------------------NEKAEATSP KITSLAFSADGTILGCGSKSGTVHLFSI---------------------GKSPMAGSSSN NINQLTFNSDSTLLGCVGDSDTIHIFKL------------------------DSTSRLLS ------------------------------------------------------------ IDGDIG------------------------------------------------------ NEDDTL------------------------------------------------------ GDTIGSGQWNE-EEE--------------------------------------------- QDTDTAPELDSAEEE--------------------------------------------- GDNSSNGHWNE-EEY--------------------------------------------- ------------------------------------------------------------ GDTSSNGQWNE-EEE--------------------------------------------- GDTSNNGHWNEEEDI--------------------------------------------- GELNEDELLQANEEN--------------------------------------------- QNKSLS------------------------------------------------------ RDIEDS------------------------------------------------------ NENSEDDYEDSDGDT------SKSSEDLNENLANL--------------------LISKP LNLDHDDGWLD------------------------------------------------- YEEDPANESDPDDED----R---SSEDLNQNLANLL-------------ISKTPDASAPD NENNEDDYEDSDGDT-------SKSSEDLNENLANL-------------------LISKP DSSGGHGFNDRGNDDSYYSDHDHSDTEAYRSSSEDLNESLANLLLSRPPPNTNEGDNSVN NDENDDQTSDYDDSDGETSRSSEDLNENLANLLIS-----------------------KP GDRSEQEDDADSTAE------EDENGRSSEDLNENL---------------------ANL GNSDEGNTEDYEAND-----HDSESSEDLNENLANL-----------------LVSNPAP GDGTDANPDSESEGSSSDLNDNLKSLLLTNPDQEQ------------------------- MSVNSEDNSHITSED--------------------------------------------- ------------------------------------------------------------ ---SDSGG---SLELIKNRIPHEQVKKFFSRKIKSHIPNQ--------N-LHRDFAHINM ---QQSSHSLSSSINGLQYISK-GLANRFGKIIVSKIPTQ--------S-QQRHVAYIKI -ILAANSNPSVGSPKETSITKP-RLADYFSKKIKSSIPNQ--------N-LSRNFAHISV ---LLEQNNDSSLKKVSKDHSK-QLKHFLSKKIRESIPNQ--------N-LRRDFAHISM -ILASNSNPSMGTPKEIPLSKP-RIANYFSKKIKSSIPNQ--------N-LSRNFAYITV ------------------------------------------------------------ -ILAANSNPSMSTAKEISLSKP-RIANYFSKKIKSSIPNQ--------N-LSRNFARITV --LASNSNPSMGTPKETPPSKP-RLANYFSKKIKSSIPNQ--------N-LSRNFAYITV -----------HRLSMQNSEPSKQIAHFISKRLGSSIASQ--------N-LRRNFAHITI ---DSQSTALLREGKLSKESTL-QFASFLSKKVISKIPNQ--------N-MERHFAHIKV ---PSASASSLMDNKFSRESSK-QLASFISKKVMSRIPSQ--------N-LTRDFAHIKV LDPVPMETEDKLSSSWFVKTKK-LINNQYTSSIIKKLPYKDYFENLIWEPPQRSFAYIKL -------------PRFAKDSPK-QLASFLSKKVISRIPSQ--------S-MARDFAYMKV QKDLAKSSYFGVLKKKVEGSSR-FMNNPYTQTIVRNLPYKNYFENLIWEPPRRAFAYVKL LDPISMEADDKLSNSWFDKTKK-LISNQYTNSIIKKLPYKGYLENLIWQPPRRSFAYIKL TAAVFNTTTTKSKKSWFGKTKDKLIDNHYTNSILKKIPYRDYLDNLIWEPPRRSYAYIKV PEPAAVEVEKKQSNSWFNKTKK-LINNQYTNSIIKKLPYKDYFENLIWEPPRRSFAYIKL LLSEREREEPASYFSALKKSAK-LLNNQYTKRIVKKLPYREYLGNLIWEAPRRSFAFIKL PVDHKQSKSYFSFSN-LKSTTK-LINNQYTKSIIKKLPYKDYFENLIWEPPRRSFAYIKL ---KENDENIYTHLKTLGKSSK-LINNHYTKTFMKKLPYKNYLENLIWEPPRRSFAFVKL ------------IKALRKDPNSKQFTKLISKTIKKSIPSQ--------A-LRRDFAHITI ------------------------------------------------------------ D------------R------I-VHTVVGFP------------------------------ P------------E------N-AKYRIGFP------------------------------ S------------E------S-NRNCLGFP------------------------------ K------------E------S-VRYCLGFP------------------------------ N------------E------S-NRSCLGFP------------------------------ ------------------------------------------------------------ N------------E------S-KRCCLGFP------------------------------ N------------E------S-NRSCLGFP------------------------------ H------------D------G-WGHCLGFP------------------------------ D------------D------S-VRHCLGFP------------------------------ K------------D------S-IQHFIGFP------------------------------ P------------ENEKDPRS-NKVEIGFN------------------------------ A------------E------D-IKHCIGFP------------------------------ PEYTPPQQ------------SKNKVAIGFA------------------------------ P------------ENEKDPRS-NKVEIGFN------------------------------ PEQSQSNCSKSPTQ--NKQKDSNKYSIGFS------------------------------ PEYIPHI------D------KELRSNVEIG------------------------------ P------------EYVPSANSRHKNVIGFG------------------------------ PEYTPP-------HTSESTSPENRVEIGFS------------------------------ AEHK----------------PDGAHMIGIT------------------------------ K------------N------TKTKHILGFP------------------------------ ------------------------------------------------------------ ---EEFDNKIYVASDDGSFKTYTIP-SKHG--QCVLNKTSHFI----------------- ---KDTTNTIHICGEDGNYLVYSIPRNEVG--PCTLVKSNTFD----------------- ---DEFPNQVYVASDDGTFSIYSIP-SRPG--ECVLTKNNKFM----------------- ---EEFPSQVYVAGDDGKFNVYSLP-STPG--ECVLMKTSIFN----------------- ---DEFPNQVYIASDDGTFSIYSIP-SKPG--ECVLTKNNKFT----------------- ------------------------------------------------------------ ---DEFPNQVYVASDDGTFSIYSIP-SRPG--ECVLTKNNKFT----------------- ---DEFPNQVYVASDDGTFSIYSIP-SRPG--ECVLTKNNKFT----------------- ---EEFPNQIYIASDDGKFRVYTLP-STTG--ECVLTKASTFA----------------- ---DEFSDRVYVASNNGEFQVWNIP-QSGG--ECILVKKSKF------------------ ---EEFPGQVYVASDDGQFQIFNLP-SMGG--ECMLVKSRIPPHGVQR------------ -----NDLVFIASYHTGNFYQYQIPKQRGPREECSLISQFNLI----------------- ---EEFPTQVYLAGNDGILHIYELP-TEHG--ECILLKNSTFST---------------- -NTNNNGHLIMLASQTGQFYHYQLPKPSDQRHECNLIAQYSLL----------------- -----NDLVFIASYHTGNFYQYQIPKQRGSREECLLISQFNLI----------------- ------ADSIFVASASGLFYQYQIPPKHGGREKCKLINEYSLV----------------- ----FNNDLVFIASHSGNFYQYQIPKHRGSREECLLVSQFNLL----------------- -----AQGVVMLASNTGTLYHYRLPKPSSEREECGLLSSNS-LCV--------------- ------NSLILLASQTGIFYHYQLPKPVGGREECYLINQYSLV----------------- -----NQFVFLASYQSGTMYQYKIPTEVDDRVECQLVNRYTLWKDK-------------- ---KEFMNQVYVLSNDGSFFIYSLP-STSG--SCVLSKQNDFK----------------- ------------------------------------------------------------ --MSDTEHSTFEPGDVYLAFVDTPVKEDEDTFIGGEPVWLADSLPPKDMLRCGACKGNFK SNIEEIHSAGEEKSDVYLGLVDAAIKEDEDTFIGGEPCWLADSPPSEEILRCDSCKSFMK SKIEELPPSDIEPGDVFLAVVDTPVKETEDSFIGGEPKWLHDSQPPVELLKCGACKSNMK SKSEENLTSDFEPGDVFLAFVDTPVKEEEDTFIGGQPIWLHDSVPSPEILRCGACKKNMK SKIEELPPSDTDPGDVFLAFVDAPVKETEDSFIGGEPKWLHDSEPPAELLKCGACKSNMK SRIEELPSSDYDPGDVFLAFVDAPVKETEDSFIGGEPKWLHDSLPPAELLKCGACKSNMK ------------------------------------------------------------ SKIEELQPSDTDPGDVFLAFVDAPVKENEDSFIGGEPKWLHDSEPSAELLKCGACKSNMK ------------------------------------------------------------ MSNVEEHASDNEPGAVYLGIVDTSIKESEDTFIGGEPVWLADSVPKKELLRCGACKSNLK SKIEELSPSDLDTSQVYLGFVDAAIKESEDTFIGGEPIWLHDSVPNMDLLKCGSCKSNMK NDEYSSDEESFDKSKVLLGFVDAPIISDEDTFIGGQPVWLHDSKPAEKSLTCDVCNGKLA SKIEEIEPESIERSQVYLGIVDAAIKQSEDTFIGGEPVWLHDSVPSQELLRCGACKSHMK HDEYSSDEEDIITSQVYLGFVDAPILSNEDTFIGGKPVWLHDSQPQDSQIKCDSCGGKMA NDEYSSDEESFDKSKVLLGFVDAPIISDEDTFIGGQPVWLHDSKPAEKSLTCDVCNGKLA NSNNDDEYFSSDNSKVVLGFVDAPITADEDTFIGGQPVWLHDSKPDEQYLICNHCNKKMA EDVYSSDEESFDKSQVLLGFVDAPIEENEDTFIGGQPVWLHESKPPQKLVTCDLCNQEMA HDEYSSDEEDVFKSNVYLGFTDVAFAEEEDTFIGGQPIWLHQSEPPAKMLQCDNCQQNMA HDEYSSDEEELVKSDVLLGFVDAPIVEEEDTFIGSKPLWLHESIPDEKLVTCDNCGKKMA MADYSSDEESILTSEVFLGFVDVPIEKDEDTFIGGEPIWLHESTPSESMVTCDNCNKKMA SKIEEVPISDVESNEVYLALIDAAVKETEDTFIGGTPLWLHESIPANDLLICGACKKNMK MDSDSDFEFDSD-TSTYLGFVDEPDSDDLDTRLGGQPIWLHESPAPQELMKCLSCHKQMP LLLQAFSPLDIAQDDRVLYVFICTKCQRKPNSVRCIRGIKKNTNRESVDKKMQLSEPKEF LLVQAFAPVDLGIYTRVLYVFYCTKCKRKNGSVKCIRGVKKTTSVDTLGQKMEL-QTTEF LLLQAFSPLDDEQDDRVLYVFLCTKCQRKGNSVRCIRGVKKNKNNDKLSEKMATSLGKNF LLLQAFSPLDYDQDDRVLYIFICTKCQRRGNSIRCIRGVKKNDHSEILSDKMAISMGKDF LLLQAFSPLDDEQDDRVLYVFLCTECQRKGNSVRCIRGVKKNKNVDSLSEKMATSLEKDF LLLQAFSPLDDEHDDRVLYVFLCTKCQRKKNSVRCIRGVKKSKNVDSLSEKMATSLEKDF ------------------------------------------------------------ LLLQAFSPLDDEQDDRVLYVFLCTKCQRKGNSVRCIRGLKKNKNVDSLSEKMATSLEKDF ------------------------------------------------------------ LLLQAFAPLDPEQDDRVIYVFYCTACPRKGNSVISIRGVRRKDAPNDLSAKMDASPGRDF LLLQAFAPLDPEQDDRVLYVFICTKCSRKANSIRCVRGVKKNSDVNNLSEKMEVDLGKNF LYLQAFAPIDGKLYDRVIYVFGCKNCSGKKGTVKVIRGIIKDALQKDMEAKLKLEKQKKF LLLQAFAPLDPEQDERVLYVFACTNCSKKPDSVRCIRGVKKCSNTDALNSKMQLGTEKDF LLSQVFAPFEGKSYDRVLYIFGCPKCSKKKGSIKCIRGISKDAARKEFDEKLRLDNTKKL LYLQAFAPIDGKLYDRVIYLFGCKNCSGKKGSIKVIRGIIKDALQRDMDAKLKLEKQKKF LLSQAFAPIDGILYDRVLYIFGCKNCSRQKGSVKVIRGIDKSAKAKELDEKLKLDNKKQL LYLQAFAPISGKLYDRVIYVFGCKNCSGRKGSIKAIRGIIKDALQKDLDAKLKLDKQKKL LLLQAFAPIESKPYDRVIYIFACKNCSRQKGSVKAIRAVNKDETQRLLSEKLQLEEKKKL LLLQAYSPLDGKLYDRVLYIFGCKNCSKKKGSIKAFRGISKDAVQKDLDEKLQLDNKKKF LLLQAFAPVDGQLYDRVLYLFGCKSCTKKKGSIKCIRGILKDAARKQLDEKLRLEDKKKM LLIQAFCPLDIDQNDRVLYVFLCTKCQRKGNSVRCIRGVKKNSTSDVVTNKINLDEGKKF MLLQAYSTLEDKYYDRVMYVFSCPECRRKPGSVRALRSIRRDREKKRDAELKKEEQQQKE KINPFDITKSDTSNPFSNPFGSQDNNPFSKSGEIDDIKEPQLSTKAQLKAAQSEHDKKKT QLNPFSANSNSNKNPFDNPFAVTGSNPFATENIKPEPKTGASNAPVSQKTLRKLHDQKKS L-NPFDIASDSTSNAFSNPFENASTNPFGGISQKEGEKREEESAKASAKAARKLHDSQKQ QINPFDLSKGEDQNPFGNPFQNSTSNPF-EVKKGPNETPKTVPSEMSTKALRKLHDSQKT QINPFDLSSDSKCNAFSNPFGGANANPFGNISQSKDEGKKKESATVSAKTARKLHDLQKG QINPFDLAPDSTSNAFSNPFGSVSTSPFGSIHSGITQKEEDESAKVSSKAARKLHELQKG ------------------------------------------------------------ QINPFDLSSESKYNAFSNPFGSASANPFGNVSQNKEEGKKKESANISAKAARKLHELQKE ------------------------------------------------------------ QLNPFGVGKNSSANPFSNPFASEAANPFS--AVDATSRDDSNKRELKPSTLRKLHEAQPA QINPFDLGNPFGSNPFADPTSSPAANPFGETKAEKEEPAQKQQQPSAKTVR-KLHDAKPK NDDLFKKKTPEASNPFGNPFSNPFGNPFSKEEEKEKEKETSKSKSYADVASKNAPKPKSD DINPFDLS-QTSTNPFAGPDDTPNANPFAPLSAPIKDNKKPVDEVVNAKAARKQHDALPS QIDLFNNSSEKSDNPFGNPFGATANNPFSKEAEDTKSHQQLTKESFAEAASKPKSHPKKQ NDDLFKKKTTQASNPFCNPFSNPFGNPFSPEEEKEEQKEAGKSKSYADVASQNAPKPRPD NQDLFKKPQGGGTNPFGNPFAKSGDNPFGQSMTTQQKKQEAAMEKVTKPVSKPKQVETKD NEDLFKKT-DTSSNPFGNPFSNPFGNPFDPKKPESTDKKTTKTPSYADVASTNAPKPKPT QIDLFDATPFGSANPFGNPFGSATPNPFAKQPERIEEPTTKVP-TYAEASKIPTVATEVK NIDLFSTDSSKASNPFGNPFASSTSNPFAGKKEEPKKEEKPAKQSYAEIASKPKKKGKSL KIDLFSSG--KSDNPFGNPFGASEN-PFAVSDTSPGAQSASIPVSYAEAVG-PAEQPSAK DINPFDLS-NGSQNPFDNPFQSSSSNPF-----ENANATEKDTKKESMKTSRKVHDSQKS KDEAMSNIGEKGSNPFANPFAAKGDNPFAEEAQEVSPSPPSPTDELISSLQKTQLAEFDC SKVFKSYLLEEESFKNKPDHLKLPKNLKIDKEALTDEDDLEKDPIKSKFDDTFQKFQEVV SKAFPGYFLEEETFKSTPDHLKLPKNLKIDKTALDAFDSLEENQMKSKFDDVFQKFQEVV TKCFKSYLLEEETFKNKPAHLQLPKNLKIDQEALDE--DLEKDPIKCKFDDVFQKFQEVV TKSFRNYLLEEETFKNKPDHLKLPKNLKIDKEALENETDLEKNPVKAKFDEVFQKFEEIV NKCFKSCLLEEETFKNKPAHLQLPKNLKIDKEALDE--DLEKDPIKSKFDDTFQKFQEVV SKCFKGYLLEEETFKNKPAHLQLPKNLKIDKEVLDE--DLEKDPIKSKFDDVFQKFQEVV ------------------------------------------------------------ SKCFKSYLLEEETFKNKPAHLQLPKNLKIDKEALDE--DLEKDPVKSKFDDTFQKFQEVV ------------------------------------------------------------ SKAFPGFFLEEESFKNRPDHLQLPKNLKIDKTAFPETDELESNPVKAKFDDVFQKFQEIV DKAFQGFFLEEESFSNKPDHLKLPANLKIEKTALDDEELLEKNPVKSKFDDVFQKFQEIV LPEYRGLFVDNEKFK-KQHDPELEKYKHLDKEEYKPSSSASASGLDSNMDKYFEMFSNTV G--FPGFFLEEESFKNKPDHLKLPKNLKIDKSAFDEEEAFEKSPVKSKFDDVFQKFQEIV LPSYPGYFVEQEKFKKVTVEPELEKYKHLVDLDDESTSRAEKKQSSSDMDKYFEAFTNTT LPEYRGSFVDNEKFK-KLGDPELEKYKHLEKEEYKLSSSASASGLDSNMDKYFEMFSNTV LPEYIGNFVEPEKFKKDTSDAELAKYKHLGDDDDLGGGSSSRRGSQSNMDKYFENFSSTV LPEYKGYFVENERFKKGKTDPDLEKYKHLEQEGDISEKVGTSMGFEANMDKCFEKFTNVV LPEYPGFFVEQEKFK--TTEPELEKYKHLIESAEDEPRERSMSSGSASMDKHFENFSSVV PA-YAGSFLDKETFKKEAADPELEKYKHLIDMDVSGSRRDSTSSVSSNMDKYFENFSNTV LPSYPGYFVDQEKFKKVTLEPELEKYKDIIEQAEGESSSGRRNSTSTNRDKYFEAFTNTV KVAFKSYLLEPESFKNKPDHLKLPKNLKIDKDALDIEEDLEKNPIKSKFDDVFQKFQEIV PKFQHGHYLEQEY--LTESQRELPQGIKIETEADETAEAVIDKEYEKLVDKHFHRFSDIV AYNPHQVLRYDLGGMPLLYAMKTEQPPRVPNPSYNQSCRVFEMQLMPKLIMDLEDETDVN SYNPGQVLRYDLGGLPLYYATPKEFEDLVAKPAYNSSRRVFEMQLMPKMILDLEEEVSLT GYNPLQVLRYDLGGKPLLYATKVDILSTLPRPGYNSSQRIFEMQLMPKMIFDLEETVSVE GYNPQQVLRYDLGGKPLFYASKIDIERTVPNPGFNSSKRVFEMQLMPKMILDLEETASLT GYNPLQVLRYDLGGKPLLYATKVDILSTVPRPGYNSSQRIFEMQLMPKMIFDLEEVVSVD GYNPLQILRYDLGGKPLLYATKVDIPSTVPRPGYNSSQRIFEMQLMPKMIYDLEEEVSVD ------------------------------------------------------------ GYNPLQVLRYDLGGKPLLYATKVDISSTVPVPGYNSSQRIFEMQLMPKMIFDLEEVVSVD ------------------------------------------------------------ GYNPYQVLRYDYGGKPLYYAAPNNFEDLVPRPSYNSSARIFELQLMPKMILDLEEEVSIE GYNPLQVLRYELGGKPLYYATKKDIVDTIPAPGFNSSSRLFEMQLMPKMIMDLEETVSLQ KHNPGQVLRYDLGGKPLLYSGKDDVAKNIPRPSFNSSERRFELQLMPKAIMDLEDLGDIL GYNPLQVLRYDFGGKPLLYSTRVDIEKVVPAPGWNSSKRVFEMQLMPKMILDLEDTVSVT KHNSSQVLRYDLGGKPLLYSGQDEIAANIPNPGYNSSNRQFECQLMPKAILDLENGDDIL KHNPGQVLRYDLGGKPLLYSGKDDVAKNIPRPSFNSSKRRFELQLMPKAIMDLEDLGDIL KHNPGQVLRYDLHGRPLLYNGKDDVAKNIPRPGYNSSERRFELQLMPKAIMDLEGLDDIL QENPGQVLRY--GGQPLWYS---------SKIGHPSGKK-YELQLMPKAIMDLEGLDDII GHNPSQVLRYDLGGKPLLYNGKDDVAKGIPDPAYNSSRRQFELQLMPKAIMDLEQSADIL KHNPGQVLRYNLGGTPLLYSGRDDIAKNVPKPGFNSSERQFEIQLMPKAIIDLENIKDIL SHNPGQVLRYSLGGRPLLYCGSDEIAPTVPNPGYNSSTRRFELQLMPKAIYDLETVGDIL GYNPFQVLRYDFGGKPLLYASKVDYDKAVPSPSYNSSKRVFEMQLMPKMILDLEETVSLE EHNPEQVVRYEFKGQPLYYA-DDEVSK--EVTELISDKKAFEFQVMPNAISQVSD--DII EGMEWGTILIYTDIQNFTPQDENDVAYVEEYVKVQWESMFGLNK----PSTGLFGNNNA- DGMDWGTIMVYTDIENYIPKDENQVGYVQEVVKVQWEP--------------MFGRSSS- NGMEWGTILVFTDVENYIPEDEHGVGYVEECVKVQWESMFGFNKASSTPAGGLFGQNGGA DGMEWGTILVFTDVENYIPTDDHDVGYVEECVKVQWESMFGSNFTKAGGSAGPFGQNNAG NGMEWGTILVFTDVENYMPEDEHGVGYVEECVKVQWESMFGLNKASSTPAGGLFGQASGA NGMEWGTILVFTDVENYVPEDDHGVGYVEDCVKVQWESMFGFSKASSTPAGGLFGQAGGP ------------------------------------------------------------ NGMEWGTILVFTDVENYIPEDEHGVGYVEECVKVQWESMFGLNKASSTPAGGLFGQASGA ------------------------------------------------------------ SGMDWGTIMVFTDIENYIPDDENGVGYVSECVRVQWEP----------MEGALHRHTGKT GGMEWGTIMVFTDAENYVPKDENGVGYVEECVRVQWEPMFNFGRSASATGGGLFGQNNNS NGMSWGTIIVCTDEEDFIPEDANQVGYIEEWCGVQWEEMFGSTTQSSTPSFGGFGSTNN- EGMEWGTILIFTDIENHIPVDEHGVGYVAECVRVQWESMFNLGRSASAPSGGLFGQSANS NGMSWGTIIVCTDAEDYMPADENHVAYIDEWCGVQWEEMFGSTTANSTPSFGGFGNTNNA NGMSWGTIIVCTDEEDFIPEDANQVGYIEEWCGVQWEEMFGSTTQSSAPSFGGFGSTNN- NGMSWGTIIVCTDVEDYIPDDENGVAYIEEWCGVQWEEMFGQASKPS-SSFGGFGSSNTA GGMSWGTIVVFTSEDDFIPEDKNDVGYVEESAFVQWE-MFGSTTQSSTPSFGAFGSNAT- NGMAWGTIVVATDVEDYMPKDEHHVGYVQEYCGVQWEEMFGATSNNTAFSFGGFGAASN- NGMSWGTIIVCTDVEDYVPEDSNRVAYIEEWCGVQWEEMFGTANNSQAPTSGGFGGANS- NGMSWGTIIVCTDEEDYMPEDRNHVGYVEEWVGVQWE-MFGSANSGFGTGGGPFGASNTN DSMEWGTILVYTDIGNCIPKDENGVGYVEEVVKVQWETMFNF---------GKTNTSFGG NGMEWGTIMVCVDPEDNLPEDKNNVGYAEEFVGVQWEKMFGSTGFGQ-KPGG-FGAANTG ---GANTGSGF-GSNAGQSSGGGLFGSTS-----NNNTGLFGGANSTTTGA-TGAGGGLF -----------TGPPVGPSTGGGLFGNT--GNQQSTSGGLFGNNNA----TSGNTGGGLF SSGNTNTGFSFGGNQAGQNTAGGLFGAKPAATMPGTTGGL-GASFGANAFG-STTGGGLF NVSGGATNTGLFGQSNNNTSTGGLFGAQNSANNANTTNSLFGGAKPSNATR-NTNTGGLF STGNANTGFSFGGTQTGQNTGGGLFGAKPA----GSTGGL-GASFGTNAFS-ATTGGGLF STGNTGTGFSFGGNQAGQNAAGGLFGAKPASTMPGSAGGL-GASFGGNAFG-NTTGGGLF ------------------------------------------------------------ STGNANTGFSFGGTQAGQNTGGGLFGARPA----GSAGGL-CASIGTNAFG-ATTGGGLF ------------------------------------------------------------ RALGPSKHMFSFGNQSGT---GGAQG----------SSGLFGQAAATGAGASGATTGTSF NSSQQQSGGGLFGQSNTNAGGGGLFGQQS-NNQLQSGGGLFGQNNSAGGGQPSAPTGGLF ----TNSSSLFGAKPNTTTAGGGLFGSSTNQQQQPASGGLFGAKPA----TGTTTGGGLF NNAPQQTLGGFGQANGTQSNNGGLFGQ---NNQQQPSGGLFGQNKPGGLFQPQQQSGGLF NKPPASSGGGLFGSSNNATNTGGLFGGNNANTNTQQSGGLFGNKPAATTGSNAPSGGGLF ----TNSGSLFGAKPNTTTTTGGLFGSSTTQQQQPTSGGLFGAKPA------TNSTGGLF SGGNGGGGGGLFGAKPATST-GGLFGQSN-TQQGNTSGGLFGSNPG----TNIGTGGGLF ------SASAFGSKPAGT-TGGGLFGSTTASTQPSTTGGLFGAKPA----TSTTTGGGLF -----NSTATFGSQQNKPA--TGLFGSSTATPAPSTGGGLFGNTATQNST---------F ------TGSGFGAKPS-----GGLFGA---NQTTNTGPGTFGS-------------GNAF NNTTNNSTGGLFGAKNTSAPSGGLFGGSNTQPQNNTQGGLFSQGNTTNQFGAPASSGGLF QPASSNTGFPFNNQQQQQQQPGGA-GCAPGASTA-TQGGGFGFNQGAAPGA-GQSTGGLF TTGNTGGGFSFGQNNNSNSTNGGGFG--------------FGQNNTSNTG--GNTGGGFF G-NSNSNTASSGGLFGNNNTNTATGTTTGGGLFGNNNAGSTSTGGGLFGTNFGASKPATG GNNNNTATQTGGGLFGAGTNNNT---QTAGGLFGSSNNTATGSTGGLFGN---SGAGSGG GSKLGNTTSTGGGLFGAGTNNVGQGANGGGGLFGS---NTAPTSGGLFGN-NSNTNSTSS GNNTANTNGTSGGLFGANANANS---NTGGGLFGNNTNTGAGSNGGLFGN-NASTNTAST GNKPNNTANTGGGLFGANSN------SNSGSLFGS---NNAQTSRGLFGNNSSGMNNASA GSKPTNIGSTGGGLFA-------AGANPGGGLFGN----------------SNSTGSANT ------------------------------------------------------------ GNKSNNTASTGGGLFGANSN------NNSGGLFGS---TTAPTSGSLFANNSSSMNSANT ------------------------------------------------------------ GQTGAGGAATGGGLFGQQGV------SNSGGLFGQ------NAGG------------SSG GQQNNNQQQQSGGLFGQNNNNNNNNNQQSGSLFGNSNATSNPAPGGLFGS-TNVTGTTSG GSQPSTNTTTGGGLFGSQNNQQQ---QQSGGLFGGTNQASNTSGGELFGGGNQTANTSGG GQSATTQ-QTGGGLFGQSSSTQQFGNSNNGGLFGQGNKPSVPGGGGLFGQNNNTSTNTSG GGNTNANTTTGGGLFGGNTNTNQQQQQQGGGLFGGNTNQQPQQGGGLFGGSSNTNQQQGG GSQPLTNTTTGGGLFGSQNNQQQ---QQSGGLFGGTNQTTNTSGGGLFGGANQTTNTSGG GQNQSGTTGTSGGLFGGQQNQQN---TTAGGLFGQQQLTGQGTGTGLFGA----NKPASS GSSQAQQQSQSGGLFGGQQQQQQ---PQSGGLFGS-SQPQQQQSGGLFGSSQPQQQQSGG G-APA---SSGGGLFGATTSAQSFGSSSSG--FGT-----AGSGGGLFGSANNATNTTGG GNNANNQQAGSGGLFGASGQNQQTQNQQGGGLFGSNSNTAGTSSGGLFGS-----KPAAG GNNNNTNQASGGGLFGNSSTTQN---ATSGGLFGSTQNQTGATGGGLFGSNTANNSSGQS GSNTSTNAGTGGGLFGSSNQTMNIGTTASGGLFGA--KPATGAPGGLFGSNIATNTTTGG GQNNNAGANTGGGLFG-------AKPTTGGGLFGQ--TGTTGTSGGFFGQNTSNTSTTGG GLFGNNSNNTGGGLFNSSNTMNATGGMGGLFGNKPAGTSLFGN-TTSGLGGGGLFGSKPT GLFGNKSAQ------PQTTGFGSSGTGGGLFGSKPAQTTGFGG----SATGGGLFGSKPT GLFGSKPAG-STSLFGNTGASTAPTQSQGLFGAKPAGTSLFGNNPANTTTGGGLFGSKPA GLFGNKTNTTGGGLFGNTGTTTATTTGGGLFGSNTS-GGLFGNNNAGSTTGGGLFGSKPL GLFGSKPAG-GTSLFGNTSTSSAPAQNQGMFGAKPAGTSLFGNNAGNTTTGGGLFGSKPT GLFAPKPAG-GSSLFGNTNTSSAPAQGQGLFGAKPTGASLFGNNTGNTATGGGLFGSKPA ------------------------------------------------------------ GLFDSKPVG-GSSLFGNTSTSSAPAQSQGMFGAKPAGASLFGNNAGNTTTGGGLFGSKPT ------------------------------------------------------------ GLFGRDTTG--------------TAKPGGLFGTQST--------------GGGAFGSKPA GLFGNKQAGNTGGLFGSNNNNTASASGGGLFGNKPSGTSLFGNNNNNNSSSGGLFGNKPT GLFGAKPANTGGGLFGQNNTANTTSTGGGLFGNKPSGGGLFGQNTANTGVGGGLFGSTTT GLFANKPAG-QGGLFGNNSSNNAVGGSSGLFGNKPASSSLFGNNNTSTGTGTGLFNNNSS GLFGSKPPASGGGLFGASNTNQQQSGGLGLFGGSSNGGGLFGGGNANQAQSGGLFGSPPA GLFGSKPASTGGGLFGQSNTSNTTSTGGGLFGNKPSGGGLFGQ-NTGSGVGGGLFGSTST GLFGNTGGTSGGGLFGNTQTGKPSS---GLFGGNSSSGGLFGN-TSNQSNSGGLFGSSNT GLFGAKPATSGGGLFGTQNNTTNTTTGGGLFGAKPAGGGLFGG-STTTTTGGGLFGGNQS GLFGSSTNNATGGLF---GSTNNTSTGGGLFGAKPAGGNLFGT-NSA---SGGLFGGNSG GLFGGSTGAATTGLFGGQNQTQNPQNQQGLFGSKPAGGGLFGA---------STSGQTPA SLFGSKPTTSTGGLFGGNSGTTNNTSSGGLFGGNSNGGGLFGNSNTSSAPKTGLFGGNNQ GLFGSKPAGIGGGLFPAGAAPSATATGGGLFGGANAGGGLFGAKPLGTTTGGGLFGNSAA GLFGAKPAAPGGGLFSNTANTGTTGTTGGLFGQNNNGGGLFGA-ATTTTSGGGLFGAKPA TGSSLFGGNSSFGSNTNGGLFGAVQQQQQP---QSALESINQLAITPLTRISDLPPQIRA T--GPFGNQQQQSQQSGLGMFGQTQNQFQQQTQQSAINFINQLAITPMTKISELPIQIRQ GTTSLFGGSNNNNMGTSGGLFGNQQQQQQQPQQQVALQSLSQLPITPMTRISELPPQIRQ GGTSLFGGNTNSNLSGGGNLFGSQQQQLQ-QQQQSALQYVSQLAITPMTKIADLPVPVRQ GATSLFGSSNNNIMSASGGLFGNQQQQLQQPQMQCALQNLSQLPITPMTRISELPPQIRQ GTTSLFGSSNNNSMNTSVGSLGNQQQQQQ-PQMQSALQNLFQLPITPMTRISELPPQIRQ ------------------------------------------------------------ GTTSLFGSSNSNNTSAPGGLFGNQQQQLQQPQVQCALQNLSQLPITPMTRISELPPQIRQ ------------------------------------------------------------ ATGGLFGGAGG---GAPGALFGTQAAPQPQ---PSALHSIAQLPITSMTRIGDLPPQVRQ G--SLFGNNNT---TSNTGFLSMQQQQQ-----QSALQSISQLPITPMTRIIDLPPQIRQ NGGGLFGNKPTTTTTIGGGLFGGGQQQQQQ-----QQQQIQTPQLTGMTRVGDLPPNIKN GFSSLFGGNNN---TASSGLFGNQQAQTQ-AQPQLALYSLSQLPINPMTRVIDLPPQIRQ SSGGLFGGSSNTSNQQSGGLFGGNTAGQQKNNQQQQQHQQQQQQLTAMTRVGDLPEPIKR NGGGLFGNKPA--TTTGGGLFGGQQQQQQQQQQQQQQQQIPTPQLTGMTRVGDLPQNIKN QGGGLFGNKPA---TSGGGLFGLQQQLQQQ--QQQQQQQQQQVQLTAMTRVGDLPPEIKN TGGGLFGSKPA--TTTGGGLFGNTQQQQ--PQLQQQQQQPQQPHLTAMTRVGDLPANIKN ANGNTFGQTKP-----SGGLFGTSNTGSTQQQQQQQQQQQQQTQLTAMTRVGDLPPQFKK ATGGLFGGNTAASSTMGGGLFGGSANQFQQ---QQQNQQQNQQQLTAMTRVGDLPPAIRQ SSGGLFGGSNQ----NSGGLFGNNNNTNQGASNNTNTSNSQQPQLTAMTRVSELSPQMKK GTLSLFGNTQSSTLGGGVGLFGGQQQQQQQSVQQSAIYSISQLPITPMTRIIDLPPALRQ TTGTGFGGGFGNTNTNTGGLFGQQQQQ-----QQQQQQQQQQLTVTPLTRPSDLPEHMQK EVEQLDQYIQKQVQISEHLKADDKDHDELVSSIPRDIAYLTKVQSMTMQSLQMDLKRISK EIEQLDQFIRTQVSLSKHLEADLQDQTELLDSIPRDIKYLQKLHFNATRSLSSDLKRIDA EIEQLDQYIQKQVQISHHLKADTKDHDELIDSIPRDVAYLLKSESATSQYLKQDLKKISS EIEQLDQYVQKQVQISAHLKADTKEHVELIESIPRDIAYLLKTESLTNQSLSQDLKKVGL EIEQLDQYIQKQVQISHHLKADTIDHDELIDSIPRDVAYLLKSESATSQYLKQDLKKISS EIEQLDQYIQKQVQISHHLKADTKDHDELIDSIPRDVAYLLKSESATSQYLKQDLKKISS ------------------------------------------------------------ EIEQLDQYIQKQVQISHHLKADTTDHDELIDSIPRDVAYLLKSESATSQYLKQDLKKISS ------------------------------------------------------------ EIEQLDQYIQRQVAISHHLRAEEDEHLELISSIPRDVQFIMKTYSLTTQSLQQDLKRIQA EIEQLDQYIQKQVSISYHLKADTEDHIELIQSIPRDIKFLLKNHSLTNQSLAQDLKKINS ELEQFDKYINTQHVIATTLNSDMSKHNNLINTIPKDINYLQNKVLSTKQALKFDINQLIN EIEQLDQYVQRQMAISQHLKADTSDHTELIQSIPRDIKYLQTIQSLTHQSLVQDLRKVTG ELQEFDKYINTQHLIATTLQSDLSKHDRLIKSIPKDTNYLYTKLSSTKQALKFDSNQLLN ELEQFDKYINTQHLIATTLNSDMSKHNHLINTIPKDINYLQNKVLSTKQALKFDINQLLN ELQQLDTYINTQHLIATTLNSDMSKHNELVETIPKDINYLQNKLLSTKQALKFDTSQLLA ELEQFDKYINTQHLIATTLNSDMSKHDDLINTIPKDINYLQNKVLSTKQALKSDLSQLLN ELEDLDKYISTQHLIATTLNGDLHKHDSLIKSIPTDVDYLHVKISSIKQALKFDIEHLKD ELEEFDRYINKQHLVATTLQADYGKHDQLINTIPKDINYLHNKLMSTKQALKFDSGQLVH ELEDFDQYINTQHLIASTLQADMEKHDHLITSIPKDTNYLHNKLTAVNQGLRFDFSQLQN EIEQLDQFIQKQVQISQHLKADEEEHMSLVQSIPRDITYLSKNQSITKQTLSQDLRKIAF EFEQIDEYIQQQARICDELSTNKLQHQEMIESIPRDAELISRKYITAYEALVHDSENMNE SKELTDNNLSDTQMFAIILQQILTPGSKI-SSLELEKFFQAKIAMYQSKLDDYFRVLSDI IKTLVDKDVKQLENFAIMLQQLVSKGFKI-SNVEIDKFFQEKLITYKHKLNDYNDTLSNI FKSLIDEDLLDTQTFSVLLQQLLTPGSKI-SSNELDKFFQKKVQLYEKKLDDYSRILSDI IKELTDQNLADTQLFTILFQQLLTPGSKI-SSLELEKFYQHKVQSYQTKLDDYFRVLSDI FKSLIDEDLLDTQTFSVLLQQLLTPGSKI-SSNDLDKFFQKKIHLYEKKLEDYCRILSDI FKSLIDEDLLDTQTFSVLLQQLLTPGSKI-SSNELDKFFQKKIQLYEKKLEDYSRILSDI ------------------------------------------------------------ FKSLIDEDLLDTQTFSVLLQQLLTPGSKI-SSNDLDRFFQKKIHLYEKKLEDYCRILSDI ------------------------------------------------------------ IKALTDDNIRDSECFSLILNQLLTPGTKV-SSAELQKFFQEKIQLYRVRLDEYFRVLSDI IKEITDQSIADSETFSTILQQLLTPGTKI-SSVELDKFFQEKIQLYKSKLDEYFRVLADI LKNMNNEITEDINKIMQLILQLSTPGTKLSSSFQLNEFFIKKIKKYYQMLTQYESMIKEL IKEITDQNIADSQTFSTILQQLITPGNKI-SSLELDRFFQEKIQHYKSKLDEYFYVMSDI LKEVNNELIEDINKIMQLIIQLSTPGTKLSSSFQLNEFFIKKIKKYHEVLNNYELIVNEA LKNMNNEITEDINKIMQLILQLSTPGTKLSSSFQLNEFFIKKIKKYYQMLTQYESMIKEL LKTMNNEVTEDINNIMQLIIQLSTPGTKLSSSYQLNEFFIKKIKNYHEMVRLYEETIAEL LKNLNNEVTEDINKIMQLILQLSTPGTKLSSSFQLNEFFIKKIKKYYELLNYYEGVIKDI IKSVNDELTEDINNIMQLIVQLSTPGSKFTSSFQLNDFFVKRIKKYRDLLDVYEGVINES LKELNNEITDDISKIMQLILQLSTPGTRLSSSFQLNEFFVKKIKKYYEILRQYEGVVAEL LKDINNELSEDLSKIMQLIIQLSTPGTKLSSSIQLNEFFVRKIKKYHEVIASYREILQEV IKETTDQSISNTQQFTILFQQLLTPDSKV-SSIELDKFFQQKIQLYQKKLDDYFRVLSDI IKTRSDIAAQEAQTCFNLLSYLTTPNSNRPNGDPLLNYFKTKCEEYEKRIEELAKVTAEV ESAVNGIHCDIFGGSHEISGSDKTGLNAIISTVIEEFKLFMSTADQIASLHQKVKLLTST DDAVSGLENDLFGNDSSEDDDTKVGVNIIVSVLIEEFKLFMDTAERIAELHQKCKEIIVK ETAVNGIDTDLFGAPNNGNATAKTGLGAIVSTVIEEFTLFMDIAERIAVLHQKTKTLASA ESAILGINNDVFGSSNSNGGESKTGLNTIVSTVIEEFGLFMDTAERIAELRQKVREITGS ETAVNGIDTDLFGAPNNPNSTAKTGLAAIVSTVIEEFTLFMDIAERIAVLHQKTKTLASL ETAVNGIDTDLFGAPSNPNATTKTGLGAIVSTVIEEFTLFMDIAERIAVLHQKMKSLASK ------------------------------------------------------------ ETAVNGIDTDLFGAPNNANSTAKTGIAAIVSTVIEEFTLFMDIAERIAVLHQKTKTLASL ------------------------------------------------------------ KSAVNGLDSDMFGSQENSTEYAKTGINSIVATVIEEFELFMDMAERVAQLHQRVKELNGS ESAVNGIDSDMFGSNPEHNPQEKTGINAIVSTVMEEFELFMDMAGRVAELHQKVREITGS EMILTGLETEGFG-----------NLFSIVQVIKSQYSLFMELTETMAQLHNEVNRLTK- ESAVRGIERDIIGATSSDG----------------------------------------- EQVISGLEVDGFG-----------GLFNIIEVIKSQFNLFMELCETMAQLHNEVNKVVK- EIILTGLETEGFG-----------NLFNIVQVIKSQYSLFMELTETMAQLHNEVNRLTK- EVVLNGLENEGFG-----------NLASIIQVIKTQYALFMELCETMAQLHNEVKRLQK- EGILSGLETEGFG-----------NLFNIVAVIKSQYKLFMELCETMAQLHNEINRLTR- NEAISGLENETYG-----------NIYNVVEVVKNQYALFMELCETLAEIHNEVDRYA-- DSILGGLETEGFG-----------NLFNIVEVIKSQYHLFMELCETMAQLHNEVNKLSK- EDVIGGLEAEGFG-----------GLFNIVAVIKSQYNLFMELCDNMAQIHNQVTKLK-- ESTVNGINDDLFGTGSNTHEASKNGLNALVATVIEEFKLFMDTAERVAELHQKVKEYTVG EAGVVGLEQSGPQNPSV-------VIDNFTISLEELYKLFMGLGNRVAELHHVVERLEQR K------------------------------------------------------MPPKV -------------------------------------------------------MSSSV A------------------------------------------MSSKPTKNQGSSGTPPT ---------------------------------------------MSSSSHNKATTKDEI S------------------------------------------------MSSRPANNQGP T------------------------------------------------MSSRPTKNQGP -------------------------------------------------MSSRPTNNQAP S------------------------------------------------MSSRPANNQGP ------------------------------------------------------------ P------------------------------------------MLRERLAASRRIFRQTP T------------------------------------------------------MPEAR -------------------------------------------MAEEKKAGGGDSAAAAP -----------------------------------------------------MAQSQGV -------------------------------------------------MSNQAKSAPNA ----------------------------------------------MTEEKKKVATAPSP -------------------------------MAAASTKSSASKSASSAGASSTPAAASAP -----------------------------------------------MSDDKKAAAAAGS ----------------------------------------------MSDAQQSTPKKATP -------------------------------------------------MSTPSNTAATP ------------------------------------------------------------ N------------------------------------------------------MSTAP ------------------------------------------------------------ -----PATT-----------------------------VKDRFLKVAKSLQFA------- -----GSTT-----------------------------ITSRFLALTKTTKFA------- -----TKDQ------------P----------------LVQRFMAVAKSLQFA------- -----AAKL------------NAAKNT-----------PYRRLTKLAKTLQFY------- ------PNL------------PARDKS-----------LVQRFMAVAKSLQFA------- -----PPTV------------PTRDKS-----------LVQRFMAVAKTLQFA------- ------PNL------------PSRDKS-----------LLQRFMAVAKSLQFA------- ------PNL------------PARDKS-----------LVQRFMAVARSLQFA------- ------------------------------------------------------------ VVYFSHPTQGANQYHMTSEARRNRSGASHTSAGEVGG-PLQRFAGLVKTLQFA------- -----PANI------------PRSS-------------PFTNLLDLAKTLQFA------- -----AIKF-----------------------------DQDKLLKTVQTLQFG------- -----PRHF-----------------------------QVSRLLQLIRTSQFA------- -----ATSK------------PATSASTTAGAPKSKGVNTSQLVETIQTLQFA------- -----AIKF-----------------------------DQEKLLQTVQTLQFG------- -----GFQI-----------------------------DQEKLLQTVQTLQFG------- -----KFKI------------DF---------------NQEKLLKTVQSLQFA------- -----TP-------------------------------PKQTLADLVKTLQFA------- -----ASSA------------KF---------------DQEKLLATVKTSQFA------- ------------------------------------------------------------ -----KVGK------------P----------------ISEKFVELAKTLQFS------- ---------------------------------------MLRIVSFTPT----------- ----------------WFAG------HFLVVVSSLLYLF---------RFCETLYRCAYV ----------------WFIG------HFAVVLCSIFYWLSLRST----SLTEIWYRIIFL ----------------WFTG------HSVVLVSSILYLF---------KMSEVYYRLVYL ----------------WFLG------HGVTLFASLCYFL---------SFNPKLYRLAYL ----------------WFTG------HSVVLISSILYLL---------KMSEFYYRSAYL ----------------WFTG------HAVVLISSILYLF---------KMSECYYRLVYL ----------------WFTG------HSIVLVSSILYLF---------KMSEFYYRLVYL ----------------WFTG------HSVVLISSIFYLF---------KMSEFYYRLAYL ------------------------------------------------------------ ----------------WFAG------HVVVLLTASMYLLGVRGS---SDFHQVVYSLLYL ----------------WFSG------HVVVLLTSLFYFGSFRSK---SQFHNGLYRLAYL ----------------WFVG------NVLTLLGFFLFTLSYFGI--LPDVGFVWYLISLL ----------------WFVG------HLVVLTCAFLFLITFRGG--ASGFHNTLYRVLYA ----------------WFVG------HVLTLWGIFLFTLTFIKS--GSRFHRFWYQLALF ----------------WFIG------NVLTLLGFFLFTLSYFGI--LPDIGFIWYLISLL ----------------WFAG------NLLTVLGFALYAFTYLGFLFYKKLYKPFWLLTLL ----------------WFVG------NVLTLLGFFIYTLSYFKVLP--DLGWIWYLVSLL ----------------WFVG------HVVTFVATLMYALTYLRV--FPSSYKFWYKLALA ----------------WFVG------HLVTLISVFFYVLTYIKFGV--GLYKFWFVLALV ------------------------------------------------------------ ----------------WFAG------HAVVILCSIFYIL---------TANEILYRLAII -----------------NSG------HLLVLVGCFFYVLATLPFFRVGKFSIFWYREIFL GVLASFGIITYQQGLH-----------------QQLSLSLLTNENVLYF--ALALVWFFT GAMESFGVLVYQTYGKALKKGDVRNGSG-----PVNFRQVIRDENVLYF--LLSATWLLS GVIESFGIIIYQQFFTRNEPLQTPGAAATKASVKSRISGLLKSEDVLYL--ILAVFWLFT GVLQSFGIIIYQQYFLKHTKN------------ASPALRVLQNEDILYF--ILASMWLLT GVIESFGIIIYQQFFTRNEPLQTQDAAATKASIKSRVAGLLKSEDVLYL--VLANFWLFT GVIESFGIIIYQQFFTRNEPLQTQDAAATKASVKSRIAGLLKSEDVLYL--VLAIFWLAT GVIESFGIIIYQQFFTRNEPLQTQDAATTKASITSRISGLLKSEDVLYL--VLANFWLFT GVIESFGIIIYQQFFTRNEPLQTQDAATTKASVKSRVAGLLKSEDVLYL--VLANFWLFT ------------------------------------------------------------ GVLESFGIIVYQQHFNLAGKQGR----------GRSLQEFVHDENFLYC--MLAAMWLLT GVLESFSIIIYQQHFKAKNQ-------------TLSIKALAQDENVMYF--AIALLWLLT GALISFGILLVQFIQKN----------------GFKVPLLIKDDNFHYF--LLAFFLIAM GVIESFGIIIYQQHFRRGSQTASAAGSGSAAK-PSFSQLLFRDDNALYV--ALAFVWLLT GIIESFGILLYQLITKK----------------ALKVNQILKDDNTQYF--LLGSVLLLI GALISFGILLVQFIQKN----------------GFKLPLLIKDDNFHYF--LLAIFLIAL GVLISFGILIFQLIQKN----------------GPRMGLIIKDDNTHYL--LLGGFLLFL GAIISFGILLVQFVQKH----------------GFKVPLLIKDDNFHYF--LLASFLIAL GVVESFGILVFQSVKKN----------------GAKLSVLLSDDNVHYL--LLGLGLFFF GVVESFGILVFQSIKKN----------------GFDFGQLIKDDNTFYF--LLGSLLLFV ------------------------------------------------------------ GVLQSFGIITYQHFHLKPKSNET----------TINLVNLLQNENVLYF--SLALVWLVT SVIATFGIIIFETYKGK----------------PLNPQALARDDNVTYL--LVAFLWLVS P----RFS-LSLVPYFMFSVFHVLVYLKTTLLPQVF--------------------NQTV P----RIA-IATIPFFIISLFHALTYIVTDIASNVLQV--------------------ED P----RFS-FSLIPFFAFAVFHVLIYVEKVFLPKVF-H--------------------LS P----VFS-LSLVPYILFSIFHYLTYLQNTLLPKVL-T--------------QTKDASGK P----RFS-FSLIPFFAFAVFHVLIYVEKVLLPKVFHL--------------------SS P----RFS-LSLIPFFAFAVFHVLIYVEKVIFPKVFLL--------------------SS P----RFS-FSLIPFFAFAVFHVLIYVEKVLLPKVFHL--------------------SS P----RFS-FSLIPFFAFAVFHVLIYVEKVILPKVFHL--------------------SS ------------------------------------------------------------ P----RFA-ATVPPFAIFSSFHALTYLKGVLLPVVF----------------------RA P----RFT-LTMIPFIIFSTFHFLTYMKSVLLPQVL----------------------QW R----AYVWITLVPFVIFTSFHVLNYVNTHLLPIVG-----------------------L P----RIN-LTMVPYVVFSFFHFLTYVKSVILPQVF----------------------DI R----PYVLIPLLPFALFSLFHVLAYTKGYLLPIFG-M---------------------- R----AYVWITLIPFVIFSSFHVLNYVNTHLLPIVG-L---------------------- R----PYVILTLVPFFVFSIFHVLAYLNGYILPIFG-L---------------------- R----CYSWITLVPFVIFSTFHVLNYANTHLLPIAG-L---------------------- S----PYVLLTLTVYILFSTFHVLSYAKHYLLPVLNIP---------------------- RS---RVL-LTLLPFGLFSFYHVLTYANGYILPIFN-L---------------------- ------------------------------------------------------------ P----RFT-YSLVPYVIFSLFHSINYMKNVLLPQVF---------------------GMT K----PTY-GTFLPFAIFSLFHVLTYVRGFILPALGYP---------------------- ESKSKVVMFIDKFVLDYNERCMYWVSTTEL-LMLFLLFV----------RAVLFFSRSWI VKKHPYLRFIDTLVSDNHETSLNAICNSEL-LCLLYNFI----------RLLTFRSRSFI SKDSSILRFIDKFVVQYNDLCMHWVGTAEL-LIFILILF----------RAILCFQRSWI IEENKIIGMIGRFNAKYNERCMFWVASTEL-LIEIILIL----------RAIAFYRRSWI KDSSKILSFIDKFVVQYNDLCMHWVGTAEL-LIFILVLF----------RAILCFQRSWI KDSSKILSFIDRFVVQYNDLCMHWVGTAEL-LIFILVLF----------RAILCFQRSWI KDSSKVLRFIDRFVVQYNDLCMHWVGTAEL-LIFIFVLF----------RAILCFRRSWI KDSSKILSFIDKFVVQYNDLCMHWVGTTEL-LIFILVLF----------RAILCFQRSWI ------------------------------------------------------------ EENNSYMRLISGFLRDNHDKSLSWSCNSEL-ACFLVVFL----------RALACRRRSWI NDENRYIALITKFIRENNDKSMVWSGSAEL-LCLIAVIF----------RALLWYPKSWL DGNNPISKHITAFVNKNNLASIQIASGIEL-LTVVWLFL----------RMITFRKRSLT GANSRLTATIDKFVRDNSDRSMVWSSFSEL-LCLVLVLL----------RALLWYRRSWI -ADRGISKQIENFISKNNTKSIQVASLLEI-YSFLWLTV----------RVILFRKRSLI -ENNPISKHITNFVNKNNLASIQIASGIEL-LTIIWLFL----------RVITFRKRSLT -EKSLASKYLTSFVSANNAKSIQVASGIEL-ITLVWLVL----------RMLAFRKRSLT -EHNPVSKHITAFINKNNLASIQIACGIEL-LILIWLFL----------RMITFRKRSLT -ETHPVSVKIGNFVAANNASSIQWAALLEV-ATLGWLFL----------RVLTFRSCSVI -ENSAISSKIGSFVANTNNKSIQLAALLEV-VTYGYLFL----------RVIAFRKRSLS ------------------------------------------------------------ SETSKVVARMDKFVTDYNDKCMHWVGSSEL-SLLVLVIL----------RTILFYPKSLI -GNAGLSLQIDNFVKTYNDKFMFTAANLEF-MMFLGLII----------KAITFQRGSWI -------VLVVFTL--FIKVKYETSKYMQAAFAQWRVRMDGVI----SHPSVPPQIKSLY -------AFVAVFL--FVRFKCYNSAHMKRSIAKWEVRLDGVI----AHPAVPHPVKTQY -------MLAVYAA--FIKLRYENSKYMKAAFAQWRVRMDGII----SHPAVPPYIKRAY -------MFALFSL--FIKIRYELSKYTKTAFAKWRVRMDGII----SHPSVPPKIKEIY -------ILVVYAI--FIKLRYENSKYMKAAFAQWRVRMDGII----SHPSIPPFVKRAY -------MLVVYAV--FIKLRYENSKYMKAAFAQWRVRMDGII----SHPSVPPYVKRAY -------ILVVYSI--FIKLRYENSKYMKAAFAQWRVRMDGII----SHPSVPPYVKRAY -------ILVVYAV--FIKLRYENSKYMKAAFAQWRVRMDGII----SHPSVPPYVKRAY ------------------------------------------------------------ -------VLALYSL--FIKARYEKSANMRAVVRKWEVRADGVV----SHPRIPAQLKRAY -------VLIIYST--FIKVRYEKSAYMRNCVKKWEVRADGIV----SSPSLPSSLKSGY -------PFLVFLV--FLKKRHEVSPFTRKYFDFFAAQGDSIV----STIN-NPVINDVW -------TAIVYCL--FIKIRYETSPYMKSGIKKWEVRLDGLV----SHPQVPGALKNGY -------PWAFYAV--FLKMRYEKSIFTRNYFKSLELQLDEAV----NKIN-NPAVKDVW -------PFLVFLI--FLKKRHEVSPFTRKYFDFFGTQGDSAV----AAIN-NPVVNDVW -------PVLVYLV--FLKKRYEVSPFTRNYLKVVKNTIDQFV----TDLN-QPILKQGW -------PFLVFLI--FLKKRSEVSPFTRKYFEHIGAQIGSVV----STIN-NPVATQVW -------PFLLYVV--FIKLRFEKSAFTRSAFKSLEMRVESSV----NSLG-NPKAKDIW -------PFLIYTV--FLKKKFETSVYTRNYFKAAEVQVDNVV----NQIG-QPQVKKVW ------------------------------------------------------------ -------MLIVYSL--FIKIRYENSKYMKTIFAQWRVRLDGVF----SHPSIPPQIKLWY -------KLIIFFV--FLRLRYAQSLFTRSVVGSWEVRVDGLL----SHPAVPPQVKQTW N-QLK-FQLVQLSKVTI-------------TRAAPGTHGSTSASTGSTGTSTSTSTSTSG T-NAKLLLRRAFITPTE----------------------------------KKGN----- N-AAK-TSLVRLSQIRL-------------SGAPPPQE-----------T-KKQN----- N-LIK-TKLIHLSGIPL-------------TSARAAT----------TEA-SKNQ----- N-AIK-MSLIRLSEYRL-------------SGAPQVT--------------KKQN----- N-AVK-MSLVHLSEFRL-------------SGTPQAT--------------KKQN----- N-AAK-TGLVHLSEYRL-------------SGVPQVA--------------KKQI----- N-AVK-MSLVRLSEFRL-------------SGAPQVT--------------KKQN----- ------------------------------------------------------------ A-KSK-MQINRLGSFSV-------------FAPFQKPSVAAGKKPMGSPA-SKHE----- V-KFK-ETIKQLNKYKL-------------LGGSTVP--------------EKKQ----- G-HVK-TAFRTIDSFKL-------------VHDRTKDE-------------DKAK----- V-LFK-NNIRELRKYNL-------------SGNAP----------------PKSM----- I-KAK-GVIRNAGGIYL-------------VNDYTK---------------EKLT----- G-HVK-TAFRTIDLFKL-------------VHDRTKDE-------------DKAK----- D-HIV-HAFAVIDQYKL-------------VHDYSAA--------------EKAE----- G-HVQ-TAFRTIDSFKL-------------VHDRTKDD-------------DKAK----- I-QVK-GVFHKVALVHV-------------AHDYTK---------------EKST----- I-QIK-DVFKKIGTVHL-------------VHDPTK---------------DKLI----- ------------------------------------------------------------ S-KGK-LALINLSKYSI-------------SKPIVQE--------------AKKN----- V-TVKHQLRKTLGG----------------AGAPVTQE-------------QRAQ----- ASASATATHSAKMD---------------------------------------------- --------------MALRD----------------------------------------- ------------------------------------------------------------ --------------MKPSS----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MSSKTNVGE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MSSKDVTKG-------------------------------EKPTSA ------------------------------------------------------------ --------------MDGTKSIK-------------------------------------- --------------MFTIEMMGL------------------------------------- ------------------------------------------------------------ -------MNNKYCTFVL---VVLLVATRLYIQPFYSLISDCDETFNYWEPLNLLLRGFGK -------GKCKLLNSSI---LLLLLITRIVIQPYYSLISDCDETFNYWEPLNLLVRGFGK -------MSCKAVSISL---LLLLFVTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGK -------CRPKVFTFGL---LTLLLTSRLYFQPFNSLISDCDETFNYWEPLNLLLRGFGK -------MNCKAVTISL---LLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGK ------------------------------------------------------------ -------MNCKAVTISL---LLLLLLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGK -------MNCKAVTISL---LLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGK ------------------------------------------------------------ ----------MPINVRAAGLLAALAVLRLYVQPLYSLISDCDETFNYWEPLNLLVRGFGK -------MYCKVISWFL---LSLLFVERLYLQPLYSLISDCDETFNYWEPLNVLVRGFGK -------MSLTPVQYGL---LFLNLLYRLY-SGLYMIIADCDETFNYWEPLNLLLRNFGK -------MAGPSWIFVIL--FSALLASRLYLQPVFSLISDCDETFNYWEPLNFLLRGFGK ------SQRLNGLQIGL---IALNVLLRVY-AAFFMIISDCDETFNYWEPLNLLIRGFGK -------MSLTPVQYGL---LILNLLYRLY-SGLFMIIADCDETFNYWEPLNLLLRNFGK ---------MTKLTRLQYALVLLNVIFRLY-SALYMIIGDCDETFNYWEPLNLLLRGFGK -------MKLSYIQYTL---LGLNVLYRLY-SGLFMIIADCDETFNYWEPLNLLLRGFGK KDSEPSTLQGESLGSQFLGTLALNIAVRVY-CGLYMIISDCDETFNYWEPLNLIFRGFGK -------VQCLL--------VGLNISIRIY-SALYMIIADCDETFNYWEPLNLLFRRFGK -------KGPSVLVYTL---LAFNLILRLY-STLFMIISDCDETFNYWEPLNLLVRGFGK -------KTFGSFIL-----IASLFISRVYIQPKYSLISDCDETFNYWEPLNLLVRGFGK ---M---ISTGDFAI-----LCLFIIARLV-SAKYSIIPDCDEVFNYWEPLHFLTHGFGA QTWEYSPEYSIRSWSFLLPFYSLLYPLNAVA---EIQANWNFYAVRIL-LGLFSLIQEWK QTWEYSPEYSIRSWAFLLPLYGILKPLNQVI---DS-KVLLFYTARAL-LGFVSFLFEYS QTWEYSPEYSIRSWAFLLPFYGILYPIDKFT---KLESHWNFFITRAC-LGFFSFIMEFK QTWEYSPEYSIRSWAFLSPFYLVLYPFNKLFIKYQWPSEWNFYLTRII-LGLVSCLLEWK QTWEYSPEYSIRSWAFLLPFYCILYPVNKFT---DLESHWNFFITRAC-LGFFSFIMEFK ------------------------------------------------------------ QTWEYSPEYSIRSWAFLLPFYCILYPINKFT---ELESQWNFFITRAC-LGFFSFIMEFK QTWEYSPEYSIRSWAFLLPFYCILYPVNKFT---ELESHWNFFITRAC-LGFFSFIMEFK ------------------------------------------------------------ QTWEYSPEYSIRSWAFLMPLQVLLLGVRRLVQAREWPTATLFYAGRAA-LGLLSLVFEKN QTWEYSPEYSIRSWAFLLPFYTILKPLGTILAKNNVPAYALFYVTRGL-LGLTSSVLEWS QTWEYSPEYKIRSYAYLIPYFILGKVCQLFD---FQ-PATVFFIIRTLGIVGFTCYCEWK QTWEYSPEYSIRSWAFLLPLFTLLSPINKIVQVFELPPSYVFYAARFF-LGLLSLVMEWS QTWEYSPDYAIRSYTYLIPYVIVTYPIKVFEKFVNIPSYYQFYWIRLIALCGFTCFTELR QTWEYSPEYKIRSYAYLVPYFILGKVCQFFQ---FQ-PATIFFIIRTLGIVGFTCYCEWK QTWEYSPEFSIRSYAYLIPYYIVGKACQFLA---GVSPVNIFYAVRIVALAGITSLCELK QTWEYSPEYKIRSYAYLFPYYILGRILQLLN---LS-PVMIFYSIRVLGIIGFTCYCEWK QTWEYSPAYAIRSYAFLIPYYILTFPLRDYIHLTGAPACAFFYYIRVVLLCGFTSFTEFR QTWEYSPEFALRDYVYLFIYYIVGSLPYHY-------SYYQFYAIRVLALCGFTSYTEIS ETWEYSPVYAIRSYAYLIPYYIVSLPITLLGQFVKFPPYVHFYWIRLIALNGFNVFAERK QTWEYSPEYSIRSWAFLLPFYFVLYPFKYYG-LLNS-EQDYFYITRGF-LGLVSFIFEIG QTWEYSPEYAIRSWAYLWAHGVAIKLSELILSATGLQKYFIFYGLRTV-FATVCVLCDFA LFKEITGTTTLEIANFWLFYQLFNPGWFHASVELLPSAIAMILQLGSINYALKYLSTSA- LSKEISSVMSLHVSIMWLLFQLFNPGWFHASVEFLPSAFAMITTLGYMKYTLRYLSTGN- LHREIASTLALQIANTWIIFQLFNPGWFHASVELLPSAVAMLLYVSATTHSLRYLSTGS- LFVEIKHTLSVQVANIWLFIQIFNPGWFHASMELLPSSIAMLLYLASMKFALRYLSTGS- LHREIAGSLALQIANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGS- ------------------------------------------------------------ LHREIAGTLTLQIANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATTHSLRYLSTGS- LHREIAGTLALQIANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATTHSLRYLSTGS- ------------------------------------------------------------ LYLELVKTTNTEVAEMWLAFQLLNPGWFHASVELLPSSLAMVLLLGYLKDSLRYLSTDK- LFNELEQCLSLQTANIWLFFQTLNPGWFHASEELLPSSFGMLMYLGSTKYCLRYLSTDS- LFCSLRRYSAS-IANWFLLLNTIAPGMSHAGVALLPSSLAMQTTMLANSFILEAIKSKNH LYNEISSTISAHGANLWLFFQIFNAGWFHASVELLPSSFAMITILGSTKYTLRYLSTGS- LFYSINSSLNRKVGNWFLFLSSIAPGMSHAGVALLPSSFAMNCVTMATANSLSAISENS- LFCSLRRYSAS-IANWFLLLSTIAPGMSHAGVALLPSSLAMQTTMLGNAFILEAIKSKNH FFVTMNQ-FSTSVANWFIFLSTISPGMSHGGVALLPSSLALQTTLLANSYLLSATKSVQN LFSSLRRYSST-LANWWLFFDTIAPGMSHAGVALLPSSLAMQTAMLANSYLLRAGTSKDA LFKSAKRNFGSHTANWFLLFSTVSTGMSHAGVALLPSSFAMNWVAWGISHALDAVTLENT LFNNIKQHIGSRVASWFLLFTSIAPGMSHAGVALLPSSFAMQCNTLAISYGISAFSGDG- LFASVSSSLGPQCANWFIFLSSIAPGMSHGAVALLPSSLALGCVSLATSYVLLYVTTPQ- LSKEIGSTLSENIGSIWLFLQLFNPGWFHASVELLPSSFAMILYLGSIKYALRYLSRDC- LYRSAKKNLSSSIAVGYAVISASSTGMFHASVAFLPSTFAMNCVTLAMSQFLNISPTGF- ---SSNFIGSLTFNMIAGILGWPFVLVLNLPLCIHYVWT---HRIISSVRTA-------- ---ELPFVKSISFVFLGGILGWPFSLILVVTNVIHYTAT---HRFMDTLRAG-------- ---TSNFTKSLAYNFLASILGWPFVLVLSVPLCLHYLFH---HRIISTIRTA-------- ---TPNFISSLTFNFVSAILGWPFVLVLSLPLCFHYLFT---HRIISTIRTV-------- ---TSNFTKSLAYNFLASILGWPFVLILSLPLCLHYLFN---HRIISTIRTA-------- ------------------------------------------------------------ ---TSNFTKSLAYNFLASILGWPFVLVLSLPLCLHYLFN---HRIISTIRTA-------- ---TSNFTKSLAYNFLASILGWPFVLVLSLPLCLHYLFN---HRIISTIRTA-------- ------------------------------------------------------------ ---EKPFVSALFYLFLAGLLGWPFVLVLGLPLVLHYVLS---HRMIVTLRTG-------- ---TKAFIISLLFNFIGGILGWPFVLILSVPLVLHYIFT---HRVTATIRTG-------- QEKQTSILRATFWYFIGGILGWPFALALGLPVGFYTIYQ---SVVIGNLPLT-------A ---QDAFVRCLLFVFVGGILGWPFVLVLGVPVVIHYVYS---HRIMSTMKAG-------- ---ANYSVQAIIWFLVGGIVGWPFALALGLPFGLFILIQ-----NIKRFNVL------FS QEKQTSILKATFWYFVGGILGWPFALALGLPLGLYTIYQ---SVFIGNFPLA-------I KSVERNLIKAAGCYFIGGILGWPFALALGLPIGLYILAR---IAKQSTSPSV-------- QNLGNNITKAIFWYFIGGIFGWPFALALGVPVGLYTMYH---TVFTGSLKFG-------I LTCVWPSVYAIACFLIAGLVGWPFALALGVPFGMFTASL---RFQSPPLVRI-------- ---IADFVIAILLFVTGGLIGWPFALALGLTFGLYTLFN---IKLWKDGKML------II ---LSSALYAVAFFSYGGIYGWPFALALAIPFGL-FIFA---SSIQNPENLL------SF ---TASFLASLTFNFVAGIMGWPFVLVLSVPLVIHYLFT---HKIMWTLRTA-------- ---VSSYCRGFVLIAVAGILGWPFALAVGAPFGLYYLLN---ITHPNAFAGL-------- -FDCSLIFLLISVIVIGIDSLFYGKFAPVAWNIFFYNVLNADEEAGPNIFGTEPFSYYIQ -VSSSFVFAIISSIVAAIDSFFYGKLSVVPFNIVMYNIISANEDSGPNIFGVEPWYYYIQ -FDCSLIFSLTAFAVIATDTIFYGKLAPVSWNILFYNVINASEETGPNIFGVEPWYYYPL -FDTSLVLFIITTIVIVVDSVFYGKFTPVSWNILFYNVINATNESGPNIFGVESWDYYIL -FDCCLIFSLTAFAVIVTDSIFYGKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPL ------------------------------------------------------------ -FDCCLIFSLTAFTVVVTDSIFYGKLAPVSWNILFYNVINANEETGPNIFGVEPWYYYPL -FDCCLIFSLTAFAVVVTDSIFYGKLAPVSWNILFYNVINANEETGPNIFGVEPWYYYPL ------------------------------------------------------------ -FSSVLVLSMILGCVFVVDSIFYRRLTLVPWNIVKYNVLGTSADSGPHIFGTEPWYYYVF -TLSLLVLAVVTVIVFSIDSIFYGKFSPVAWNIVMYNVIGANENSGPDIFGIEPWYYYVL LFRVLSVLLTVVVPIMIIDSFFYQKVSFIPINIVLYNVFG-GEGEGPEIFGVEPFSYYIM -FRALMALALVLGSVFAVDYIFYGRFTPVAWNIVMYNVIGADEKSGPNIFGVEPWYYYIL IIKGCIAGLVSTLISTAIDSWFYQKLDLVPLNIVLYNVFG-EQGEGPEIFGVEPFHYYIL LFRVLSVLLTVVIPIMVVDSVFYQKVLFIPINIVLYNVFG-GEGEGPEIFGVEPFSYYIM LVSVFVVAISIMVPVVLIDSYFLQKWVFIPANIVLYNVFG-GDGEGPEIFGVEPWTYYVL YFKILAVLSGIVGLVVLIDTIYYKQFMFIPINIVLYNVFG-GEGEGPEIFGVEPLSYYVL VIYCSIFAFALCGVLMTLDSFFYRKMLFVPMNIVLYNVFA-GEGEGPEIFGVEPFSYYAK IGGCASGTALILAVVGVVNSYLYCKYLLVPLNIVLYNVFG-GEGEGPEIFGVEPFSYYIL AIRALAIVGAMTALIVAIDSAFYKKLLLVPLNIITYNVFG-GEGEGPEIFGVEPFIYYVH -FDSTVIITVIASIIFTIDSYFYGKFAPVSWNILSYNVINADQNSGPDIFGVEPWSYYVL -LKALMAIGTIAGITLAIDSVSYRSLQLGTLNIVLYNVFG-GEGQGPEIFGVEDWKYYLH NLLLNFPITTLGFAVLGVS------------------------HWRLWPLWTSAIVWFTV NLLLNFPITTLFFGVIGFT------------------------QLSIWPLSGSLFIWLNV NLILNFPLPVLILAALGVF------------------------HLRLWPLWASLFTWIAI NLTINFPLPVLFASLIGIF------------------------HLSLWPLWTSLLTWMII NLLLNFPLPVLVLAILGIF------------------------HLRLWPLWASLFTWIAV ------------------------------------------------------------ NLMLNFPLPVLVLATFGIF------------------------HLRLWPLWASLFTWIAI NLLLNFPLPVLVLATLGIF------------------------HLRLWPLWASLFTWIAI ------------------------------------------------------------ SLLLNLPLPTLIFAIVALL------------------------HTNLWPVWCSLFAWLVV NLLLNFPLPVLIFSVIGLL------------------------HLQLWPVWGSLVVWMGI NLLLNFNA-IFPLAVIGVFWNPILTHV----------------KAFSSFVSLQLVIWFGI NLLLNFPLPVLLGSFLGIA------------------------NLRLWPIWGGLVTWMAI NLLVNFNV-VAILGYVGLVMNVVLFGEKNR-------------YKVLITVSLPLLIWSLI NLLLNFNA-IFPLAAVGIFLNPVLTQF----------------KVFSSFVSLQLIIWFAI NMALNFHA-IVPLSIAGTLFNPVFTNL----------------KKFSLLVSLQLIIWYAI NLALNFHV-IFPLGVAGMALNPMISQG----------------KEFSTLVSMQLIVWMGI NLFLNFNV-ISVAGYLGAALNPLLSKNQ---------------LKAALGVSLPLFVWSFI NLLLNFNV-VFPLAYAGSLMNPFLYSKS---------------KLSFVVASMPLLIWSFI NLLLNFNATLLLASAGCFLSFGLRSKQR---------------TKVIVTCTFPLAIWLSV NLILNFPLPVLIFSIMGIA------------------------NWRIWPLTVSKLSWLGV NLLLNFNI-AYPLSILAFATPVLFYLLPASSTSLRVH------PARLALTTSPLLLWSAI FALQPHKEERFLYPLYGYISLSASILTYKALK-----------VYKKYFSFAFVVK---- FLAQPHKEERFLYPIYGIISLLAAVGLFNITVW---------KKLRKLVR---------- FIQQPHKEERFLYPIYGLITLSASIAFYKFLSFFNKK-----TVLKKGIR---------- FINQPHKEERFLYPIYPLISLCGSVGLYHCFHFGKKSSHHSLRHIRRFFK---------- FTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRK-----PILKKGIK---------- ------------------------------------------------------------ FVQQPHKEERFLYPIYGLITLSASIAFYKVLTLFNRK-----QILKKGIK---------- FIQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRK-----RILKKGIK---------- ------------------------------------------------------------ FIAQPHKEERFMYPIYAFVTLASSIGFTKVSKLLWRS-----KLYRHSFK---------- FFSQPHKEERFLYPIYSTLTLSASVGLVNCLK----------KLPRWKSLLQLTK----- FFAQPHKEERFLYPVYSLITLSAAILLSKL--TIGSKNFASKPIYRVFQ----------- FFQQPHKEERFLYPVYALVTLAASVGFANIWK----------RLERLKAGRSLLL----- FGSQPHKEERFLYPVYPLLILSSSLLLTLIFPMVTFV-SKGIAANKINSKHIEKLVQ--- FFAQPHKEERFLYPVYSLITLLAAILLSKL--TIGLKNFALKPIYHVFQ----------- FFSQPHKEERFMYPIYPLVSILAAIFISKVFN----------VLKKISVARRLQFVAK-- FFSQPHKEERFLYPIYSLISLSAAIFLSKLAL----------GVKRFISKKVFTILQ--- FFSQPHKEERFLYPIYPLISLSGSIFASTVFG-----NAQVLLKSKWLVRFIS------- FFGQPHKEERFLYPIYPLICLNAALLTSKLFSIHSQIFGKVVQSPNYIRRVWSAFVQ--- FASQEHKEERFLYPIYPLIVLSASVFLSWFLTTSTSIIRSLTSSDKLTILYKQFFI---- FFLQPHKEERFLYPIYGLISLSAAIGFHQFSNFFGKM-----KVFKSIVK---------- FYMQPHKEERFFYVVYQLIALSAAISLEWISA----------VVHAVGLKGLKALTI--- -LIIVGTVILQSLLRIFALIENYRAPMTVYSELFSRESTSNST----------------- -GIVFFVTLLQAASRILALTNNYTSPIQVYSHLPESTEN--------------------- -LSVLLIVALQGMSRIVALVNNYTAPLAVYEQLSSLNQGGVKSPL--------------- -WVTMLLIALQATSRIVALIENYTAPIKLYEEFNKMDVTTDEK----------------- -LSVLLIVAGQAMSRIVALVNNYTAPIAVYEQFSSLNQGGVKAPV--------------- ------------------------------------------------------------ -SSVLLIVAGQAMSRIIALVNNYTAPIAVYEQFSSLNQGNVESPV--------------- -LSVLLIVAGQAISRIVALVNNYTAPIAVYEQFSSLNQGSMKTPV--------------- ------------------------------------------------------------ -GAVFAVLICQSVLRITALVNNYTAPLHVYSTLEPSDAP--------------------- -FGVIALVSIQSSMRILALINNYTAPLTVYSELPVSDDI--------------------- -LGFILSIVVVSSLRILNLVENYGAPLQTFNTVAQLEDLGQSLQSP-------------- -LGVCTLTLSQASLRIFALVQNYQAPLDVYAHIPNV-VGP-------------------- -LLFAFSVGMVSILRIINLVENYSTPLSVHREISTLPVSNIS------------------ -LGFILSVVAVSSLRILNLVENYGAPLQTFNALSQLEDLDQSLQSP-------------- -IATVLLLFTISVLRIFNLVENYAAPLQVFYKLAQLPIPGDL------------------ -AGFILSLITVSNLRILNLVENYAAPLKTFNTVARLEEATTTSP---------------- -FSSMVLIAVVSLLRTVNLVENYSAPLKASAVFFNESILNDTTEI--------------- -GGFALAIITVSILRIINLVENYSAPLVVFSSVAGLPQGNDI------------------ -VAFATVVGSISILRIMNLVENYSAPITIFRQVAELPPKTTI------------------ -VALLLIIALQSASRILALIFNYTAPITLYSELYTLGKDDKVLAQDSF------------ -ALALSGIASISVLRSVSLAQNYSAAIHVLKTPQLYE--GEG------------------ VNVCTGREWYHFPNSFYLPNAHRLRFVKSGFDGLLPGDFIEDE----SIFTAVRAVPKGM KVVCTGREWYHFPTSLILPDNYRLQFVQSGFDGLLPGDFLETG----TLNEKIRSVPNGM VNVCTGREWYHFPNSFLLPDNHRLKFVKSGFDGLLPGDFQENG----SIFKKIRTVPKGM INVCTGREWYHFPNSFFLPESHRLQFVKSGFDGLLPGDFMESE----SFTKNIRTIPQGM VNVCTGREWYHFPSSFLLPDNHRLKFVKSGFDGLLPGDFPESG----SIFKKIRTLPKGM ------------------------------------------------------------ VNVCTGREWYHFPNSFLLPDNHRLRFVKSGFDGLLPGDFPENG----SIFKKIRTTPKGM VNVCTGREWYHFPNSFLLPDNHRLKFVKSGFDGLLPGDFPESG----SIFKKVRTIPKGM ------------------------------------------------------------ VNVCTGREWYHFPASFFLPDSHRLRFVNSGFDGLLPGDFPEEM----PLLEVISQVPEGM VNVCTGREWFHFPASFFLPDNYRLKFVQSGFDGLLPGDFLETG----SLFENIRAIPSGM INVCMGKEWYHFPASFFLPDSYRLRFVDSGFDGLLPGDFFEST----NVIDSTTFIPKNM QTVCVGREWFHYPTSLFLPYNFRLGFVQSGFDGLLPGDFKETD----RILNSIRNTPGGM VNVCTGREWYHFPNSFFLPDNYRLKFIRSGFDGLLPGDFLEGA----SLKASTSSIPPNM VNVCMGKEWYHFPASFFLPDSYRLQFVDCGFDGLLPGDFFELT----NIIESTTFVPTNM VNICMGKEWYHFPNSFFLPDGYRLQFVESGFDGLLPGDFYELK----SIVDSTTFVPMNM VNVCMGKEWYHFPASFFLPDSYRLRFVECGFDGLLPGDFYESD----NIFESTTHIPANM QNVCIGREWYHFPTSFFLPDNYRLRFVSSGFDGLLPGDFPEDM----TLREAASAFPSGM QNVCIGREWYHYPNSFFLPDNYRLRFVKSGFNGLLPGDFNE---EFSTLREQTAFVPQHM TNVCVGREWYHFPASFFLPDNYRLRFLRSGFDGLLPGDFKESS----SILESTSTFPDDM TNVCTGREWYHFPNSFFLPENHRLRFIRSGFDGLLPGDFMEDV----SIFDAVRTLPKGM TTFCLGREWYRFPSSYFLAPHQRLRFVKSGFKGLLPTSFEESD-NMWWNLPGTSSIPLHM NNRNMFDESKIWPLEECDYFVDITLPTD-GEKDSFTGSNSANR--WNAVVCQKFID-GSD NNQNIFDPSKVVDIDSCDYYVDINVSSN-NQKDAVNP---ADTTAWVPLYCLPFVD-TSS NNKNIYDAGKEWPLDKCDYFVDIVAPID-LTKDVFNPLHLTDG--WNKLACAAFID-AEN NNLNKWDESKVSPLNQCHFFIDVVLPID-ITNDSFDPYS--ED--WTKLSCYNFVD-VDN NNKNIYDTGKEWPITRCDYFIDIVAPIN-LTKDVFNPLHLMDN--WNKLACAAFID-GEN ------------------------------------------------------------ NNKNIYDTGKEWPIAKCDYFIDIVTPIN-LTKDVFNPLHLMDN--WNKLACAAFID-GEN NNKNMYDTGKEWPIAKCDYFIDIVAPIN-LTKDVFNPLHLMDN--WNKLACATFID-SEN ------------------------------------------------------------ NQFNKFDPGKVVSIDMCDYYVDIMMQSD-PEQDVFDPTDMPLG--WEISTCAPFID-GAN NNENKFDPGKLTSVDQCGYYVDFLVPSD-YSKDSLDPINIGVE--WEKVYCTPFVD-APH NNKNQFEKDKVIDLEHCHYYVDNSQLNS--YPQLVYPNLSTTG-KWEVITCNKMLDPNEK NNQNLFDASKLVHVDQCDYFVDFMLPSD-NPRDVLVPSNLPEG--WSKIYSAPFVD-TVT NNKNQYSDDKVIDFDECSYYIDNSQAAN---LEVGEPNIVERSKGWSVVQCQNIINPSGT NNKNRFEKDKVIDLDDCHYYVDNSQLNS--YPQLIYPNLSTTD-KWEVIKCNKMLDPNEK NNKNKFEPDKVVDLATCDYYVDNSQSES--TPQLLNPDLSVDN-EWDVLQCDKLLNPHGS NNKNKFESDKVVSLTECDYFVDNSQFDS--IPQLLYPNLTTAP-GWEVMDCNKMLNPNGH NSKNIFSPEKLVHFSTCDYFIDNTAPVD---TTKGEKQIVSMENAWDVLDCQKIINPAGS NNKNQFEEDKVVTLETCDYYVDNTEPV-----AEGELQLVLKDLGWDILKCHKLLRPDGH NNKNMFSAGKVISLEQCDYYVDNTGPID---EESGEPFIFLNSAGWDIIGCEKIIDPAGK NSKNIFDEGKLWPVTNCDYFVDISIPTD-KSKDALNPSDMPRN--WNKISCTEFIN-VDD NNLNLEAPELYVEPSQCDFVVDIDIPAN---SEEGEISYF-TSPEWKKINCRKFLD-FES SKFLGRAFAVPEIIDCMMKEYIPELWTKLYHAKYIDYCLYEKLPSSEYQVNAD------M SKFLGRAFQVPAQLIAILPTRIRQIIKNYYDVQFINYCTFVRRHESDSLV---------S SKVLGRAFYVPEFVNQIMQTVLPKQWNQVYGVHYIDYCLFEKPTETIN-----------M SKLLGRVFYIPKCFNDLIKRIVPKSWESLYGVNYLDYCLFERIHYAPDEQS--------S SKILGRAFYVPEPINRIMQIVLPKQWNQVYGVRYIDYCLFEKPTETTN-----------M -----------------------------------------------------------M SKIFGRAFYMPELINQVMQRVAPKQWNKVYGVHYIDYCLFEKPTETIN------------ SKILGRAFYVPESINQIMQKVLPKQWNQLYGVRYIDYCLFEKPTETTN-----------M ------------------------------------------------------------ SSFLGRAFQIPASVLSRLPKSVRALVERYHKAKHLQYCVFKNSAAELA-----------S SRFFGRAFQIPNGLIEYIPRQLQNIWNTVYGVEFTEYCLFERKREVV------------S HSTIGKLLYVPT-------------WLRPYDVGYMEFCLLKKQDIEDTV----------S SKFLGRAFLLPERLIALIPSNLQSYWTRVYGVEYLEYCIFKREMEEV------------S SSGIGKLLWIPE---------YVRSLIP-YNVDYMDYCLVERKKNIV------------Q HSTIGKLLYIPR-------------CLRPYDVSYMEFCLLKKQDIKDTV----------S HNMLGKMLYIPT---------PLRKWIP-YNVEYMQFCILKNRVEKQHP----------R HSFIGKLLYIPY-----------------FRVERMDFCVLKKVVDV-------------N HHGLGRLLYIPE---------SLRTVVPN-SVEYMDFCVLRRKK---------------Q HDGIGRFIYIPM---------SLRLIVR-YNVEYMEFCVLKR----KNGMV--------Q SSGIGRILWVPV---------AIRKWVP-YNVDYMNLCLAEKRSQ--------------N SKILGRSFYIPSTIAKFVAKFSPKYWNKLYGVNYIDYCVYEKTEIVQDNTSI-------M SGP-GKLLWLPK---------SLHGLTK-TSLKHHEYCLFEKV--KNE------------ SLSNMLRASRLAQVYKSSKPLS-TLKIAPTHQVIETKPALLKFHEWGLKSAIPSKVKTQY HISNLLKNSRIAQVAKTDKPLFRPNSSHPTHQVIETKPSSLYRQEWGLKASIPSKIKTRY TLAELLGRSRIAQVANNHKPLTYTKKFHPTHQIIETKPSTLYRQEWGLKSAIPSKIKSRY RISNLLRSTRVAQVPKNNKPLNPIHKYFPTHQIIETKPSSHHRQEWGLKSSIPSKIKSRY TLAELLGRSRIAQVANNHKPLTYTKKFHPTHQIIETKPSTLYRQEWGLKSAIPSKIKSRY TLAELLGRSRIAQVANNHKPLSYTKKFHPTHQIIETKPSTLYRQEWGLKSAIPSKIKSRY ------------------------------------------------------------ TLAELLGRSRIAQVANNHKPLTYTKKFHPTHQIIETKPSTLYRQEWGLKSAIPSKIKSRY -------------------------------------------------SSIX------- NLSSILRNSRIAQVPKPKGPLFSPKKYVPTHQLIENKASTMHRQEWGMKSSIPSRSKSRY NLSHLLRNSRIAHVPKSKKPLNSAPRFHPTHQIIETKPSTLHRQEWGLKSSIPSKVQTRY ELFNLVKNSRLAQVAKPLSNNIRGNSKTPTHQVIFTPKSSALRSDYGLKSTLPNKIGSSH NLSHLLRNSRLAQVPKSKKPLTSAPKYAPTHQIIETRPSTLHRQEWGLKAALPSKTKTKY ELYNLFKNSKLAQVATPLHKTLRGRDNVPSHQIIYTPKSSAIRSNFGIKTALPKQIGFSH ELFNLVKNSRLAQVAKPLLNNIRGNSKTPTHQIIFTPKSSALRSDYGLKSTLPSKIGSSH ELFDLVKNSKLAQVSTPRSKLIRFSRTKPTHQTIYTPTTSALRSDYGMKRTLPAKYGKSH ELFNLVKNSRLSQVAQPLSKNMRAKSNIPTHQVIFTPKSSAARSNYGLKTTLPNKIGSSY EFYKLFKNSKLAQVATPLSKKLRGNTSAPTHQIIYTPTASAARSNFGIKTSLPKQIGQSH ELFNLVRNSKLAQVATPILKNIRGKSSVPTHQIIFTPKSSAVRSNFGIKTTLPKQIGYSH ELYGLLRNSRLAQVATPLSKKLRGESHIPTHQIIYTPKSSAIRSSFGIKTQLPKQVGQSH SVSQLLRKSKIAQVVNTKNP-LYVNKFHPTHQLITTKRTNFNQNDWGLKSPIPSRDNSRY ------------------------------------------------------------ LMYKELDTLERLTDFEPRGGANWNRIRVQEFGLSPRYNANTKNPLFNKEHYDFSSLNEVF LVYNDLDTQQRLTTFEPMGQYQWNRIRFQEMGLAPRYVEEESNPLFNGKTKRAGKYAPFS LVYNDLDTLERITTFEPRGGTQWNRLRFQEMGVPIVSNIGRQNPFFKDPSRSEDDSDAKL LVFNDMDTLERLTTFEPHGASQWNRIRFKEMNLAPTYNMGKLNPLFGNESVVHDQAYTLS LVYNDLDTLERITTFEPRGGTQWNRLRFQEMGVPIVSNIGRQNPFFKYISRPEDESHAKL LVYNDLDTLERITTFEPRGGTQWNRLRFQEMGVPIVSNIGRQNPFFKDISRSENDLDARL ------------------------------------------------------------ LVYNDLDTLERITTFEPRGGTQWNRLRFQEMGVPIVSNIGRQNPFFKDISRPEDESDARL ------------------------------------------------------------ LIFDELDTQQRLTSFEAIGQYQWNRIRIQELGVVPERATAGSNPLFSGFSSRLSARTPLS IIFNDLDTLERLTTFEPNAGSQWSRLRFQELGVAPSYNAGKSNPLFEGSSSSSNQLVPLS ISFNDIDNRQSMPDVEKNSGFHYKQLMFQELGLCIKTHFTNKNPLFYHENNKSNKPMKDG IVFNDLDTLERLTTFEPSGGAQWNRIRFQELGIAPKYNPGKANPLFETSGLAKTQLVPLS IVYNDIDNPKNMPDVESYSGPLYNRLKFQETGVAVKNYFNENNPLFPSKTTKSTSTSQLD ISFNDIDNRQSMPDVEKNSGFHYKQLMFQELGLCVKTHFTNKNPLFYHENNKSNRSMRDG IAFNDIDNAKEMPDVEKESSFHYTRLMFQELGKPLAQRYSTENPLFASASNKSNLLPPEY ISFNDIDNRQSMPDVEKNSGFYYKQLMFKELGLPVKTHYTGKNPLFPDELNKSDRPMRDG IVFNDIDNFKNMPDVEKHAGPHYTRLKFQESGIVLKKAYKKSNPLFAWNSSKTKEASTTD ISFNDIDNYKSMPDVEKNSGKMYNRLKFQETGLVVNNHYTDSNPLFPSGNNKSNSKQRDH IVFNDIDNPKNMPDVEKYSGKYYNRLKFQETGMVVKNYQNESNPLFPSSTTKSTTSNKVD LVYNDLDTLERIATYEKNNGQQWTRIRFNELNLTPTFNPGVANPLFKSNSVQTDNSSPLS ------------------------------------------------------------ TKFKQQHGSMKYGSESRKLFIKNVRQEFKEWLVAKYPEAILTKPDNMLTYGKEFLQSYSS NAVNIAHNTAPSEKTRKLKEIDQHRSEFKKWLLEKHPDSIAENTRPLKALATEFLHEKIN SLFDISPGAMEKRLEKTIRLIKSFQKEFKEWLVENYPEELRLNSNKLEDYVVKFLNKKLK SLLNIDPELNSKGKITKLNSLKKLRAEFKSWLLERDPEALKFSAKEMQSNVTDFLNERSS SLFDISPAAMKKRLKKITALIRSFQDEFKEWLVENHPDELKLNSNKLEDYVVKFLNKKLE SLFDISPAAMEKRLKKIITLIKTFQKDFKEWLVEKHPDELRLNSNKLEDYVVKFLNEKLE ------------------------------------------------------------ SLFDISPAAMEKRLKKITALIRSFQNEFKEWLVENHPDELKLNSNKLEDYVVKFLNKKLE ---NVNSGNATTQVNSRLPSVKAMRNEFKQWLLSKDPEASKFXPRDLHSFAVQFLSERDS SFFGLTSKSDAKQWKAAEKKVAALRPAFKKWLQDHHPHLIIMDPADFRKRAVEFITEIAT SLLNIDPTSSRTDVEKKLSQVKSLRKVFKKWLLSKDPEALKFSAKDMSDNAVEFLSESTN SLINLPTKVQISEINKILKKNPQIYKEFRQYLIENHPNILLTNLKQFLSTSSKISKKKTH SLLNVDPSTPKPEIERRFAQMKDLRSAFKKWLLEHDPEALVFNAKDMTDSAVEFLAEIYN SVLNLTNNATGADVKRLLQKNPDLYKKFQAWLVKNSPESVMSKLKEFLATTSDIKKQELS SLSNLPTKVQILEINKILKKNPQIYKEFRQYLVDTYPNILLSPLKNFLSTSSQISKKKTH KLANLPEKISTGKVLEILRQTPDIYRKFMDYMAKTHPEVVLFQ-GETKEYLMEFLKQSEA SLANLPTKVQVSEIVKILKKNPEIYDQFNKFLIKNHPKILLNQLKEFLLSSPEVVKKRQH SVLNLGQDSDISEVKDLIKRNPDLRAEFKKWLVVNSPESVMSKLKDFIASSPTLVKREMT SIANLHAKASAEEIRSILEQNPKLHQKFQKWLLVHHPQALVQSLRRFLSTDAAVIKKELA SILNLNDNATTADVTRLLSKNPELNKRFQQWLLKNSPRSLLRYLRRFLSSQSDIVRQELA SVLNLNSNASSNSNRLKIGNIKNLRSDFKKWLLDNDIDSLKFNVKYMNRSAINYLNDKHD ------------------------------------------------------------ SKLNSP-DTMIGTGGLTYALKGRLRNSPNGVIQKHIVPGRFVANKIAAIGGFVANAASSV TAANSE-WHIVGTGGLTYNLKGRLRQSPNGVKQKHVVPGRVLSDRAVAVGGFIAEAKSVG AKTSNKFSEIIGTGGLSYSLSGKLKNSPNGVIQRTVVPGRVLNNKLAAIGGFVADVVFFQ GQINNHSQKMIGSGGLSYALPGKLKTSPRGVVSKTIVPGRCLNSKTVAVGGFVTTALGDK TKTNKKFTEIIGTGGLSYSLPGKLKNSPNGVIQRTVVPGRILNNKLAAIGGFVADVVFFQ KKTSNKFSEIIGTGGLSYGLSGKLRNSPNGVIQRTVVPGRVLNNKLAAIGGFVADVVFFQ ------------------------------------------------------------ TKANNKFTEIIGTGGLSYSLSGKLKNSPNGVIQRTVVPGRVLNNKLAAIGGFVADVVFFQ KRLNKATKNVVGTGGLTYSLPGKSKNSPNGVVAKNIVPGRFLNDRLAAIGGFVANASSSS RSSGAGGWKVVGNGGLTYGLKGRLQQSPLGIKQNTVVEGRILQEKSVAAAGFVGNGMLGT TGLNSASNKVIGTGGLSYNIGGRLRQSPNGVVSKTVVPGRFLNDRLAAIGGFVANAGSSS KIDPKFQNQIQGTGGFSYNQKGRLRNTPNGIKYGTVVPGRIIANKEAAIMGFVASVTDRS SDLNSSSRRIVGTGGLTYNLHGRLRNSPNGVISKTVVPGRFLNDRLAAIGGFVANAGSSS KSTNRAPNKIQGTGGFSYTQKGRLANSPNGIRHGSIAPGRMVGDREAAIGGFIASVNDRT KIDPKFQQQIQGTGGFSYNQKGRLRNTPNGIKYGTVVPGRIIANKEAAITGFVASVTDRS VSTLSRHKNIEGTAGFSYNQRGRLQNTPNGIKYETIAPGRMVGTKEAAIAGLTASVAERS KINPKFERQIQGTGGFSYNQKGRLRNTPNGIQYGTVVPGRIIDNKEAAIAGFVSSVTDRS RVSSHAPSHIQGTAGLSYLQNGRLTNTPNGVKQGVIAPGRIVREREAAIGGIIAAVNERT KIGSSAITHIQGTGGFSYSQKGKLTNTPNGVKYGVVAPGRLVGNKEAAIGGFVVGVNERT RATSNAPTKIQGTGGFSYAQKGRLTNSPNGVKYGVIAPGRMVGDREAAIGGFVASVNDRT TNLPTNNTHVIGTGGLSYNLRGKLQNTPNGIKQKTIVPGRYLNSKLTGIGGMVGFENSSF ------------------------------------------------------------ ISAQPQKWVSN--RDKIYPFEVSNLSVNN-GQITLDAKMLNPEQKRRNHYPKPLYGNRYS RNPRAQYNMGDFVRQEVLPFAIEDPKVEG-GNVTLSASLVEPRNDRSHYTRSDSRNSRSV SPPNSFNSMGDFIRMKTFLFEILEASMEKNGSVSMHARLLEPQNDREFFNKRPIYKPSRR LKNQN-KNMDSSIRENVYPMEVQEASIDPNGRVNIKTDIILSHNQKTEYQMNPLWKKSSR SPPSSFNSMGDFIRMKTFLFEILEASMEKNGSVSMHARLLEPQNDREFFNKRPIYKPARR SPPNSFNSMGDFIRMKTFLFEILEASMEKNGSVSMHARLLEPQNDREFFNKRPIYKPARR ------------------------------------------------------------ SPPNSFNSMGDFIRMKTFLFEILEASMEKNGSVSMHARLLEPQNDREFFNKRPIYKPARR PMTSQDYNMGDFVRELTFPFEVQQASVEDNGRVMLRAKVVSARLQGRNYQQRPLRTGPAV NLRKVDYAMGDLVRTARFPFEVKQARLLENGRLLMDMSLIEPKNTKENKNRTYIFQRRKI PNTSQDYNMGDFIRELKFPFAVNRAFVQDNGKVVLRANVISARMQGKNYQQRPSRTTPAV ITLQSKNAPGKHHRQFTVPFKINEAELGEDGSIRFFAEGIKKANDNRYVPTKTNFASSSE VTTSQDYRMGDFVRQLQFPFAVNHATVQDNGKVVLRANVVSSRIQSRNQQRPPKRGARSA TLLQNKNYPGKHPRQFVMPFKINEAEITENGRVKVYADGIKQRTNSNYEASNPNFGSASE ITLQSKNAPGKHHRQFTVPFKINEAELAEDGSVRLFAEGIKEAND-RYVPTKTNFASSSE AMMQYSNAPGKHSRQFNAPYQINDAELAEDGSVRVFALGIKSENDRRYAEARKNMSFKTE IALQTKNYPGKHHRQFTVPFKISEAELSEDGSVRLFAEGIKETND-RFTPSRTNFAGSSE TLLQSKNAPGKHSRQFVMPFKVNEAELTPTGGVRLHADGVKQRSDSNYIASNPNFGTMSE TLLQHKNAPGKHSRQFVMPFKINEAEITETGSLKLYADGIKQRSSSRYTASNPNFGSASE TLLQHRNFPGKHSRQFVMPFKLNEAEITGNGSVKMYADGVKQRTNRNYEASNPNFASASM SPTRLDRMNAETAREKAYPFEVQRISVDHKGNIMMRSRVVN--DNREDFQRRPKSSRRAV ------------------------------------------------------------ TGERKSDVAESLKAILEFN----------------------------------------- TAEESRSQSEEFLNLLKTT----------------------------------------- PSVGNIQEANNLLNIIKGN----------------------------------------- MVSDNAKQAADLLEMIMKG-------------------------------MGRKGTTNSV PSVGNIQEANNLLNIIKGN----------------------------------------- PSVGNIQEANNLLNIIKGN----------------------------------------- ------------------------------------------------------------ PSVGNIQEANNLLNIIKGN----------------------------------------- RAEDSTKHAEELLSILTNF----------------------------------------- SSEESAQQAEELLNILTNF----------------------------------------- NPEDSTKYAEELLNILTNF-------------------------------------MALA RNKADGKSLESLLNLILPT----------------------------------------- SAEDSTKHAEELLNILTNF----------------------------------------- RNSKDNIPLESLLNLIGNS----------------------------------------- RNKADGKSLESLLNLILPT----------------------------------------- RNRVNDESLENLLNLILPK----------------------------------------- RNKADGQSLESLLNLILPT----------------------------------------- RNSKDSSALESLLGLVSKS---------------------------------------MT RNKTEGENLQRLLNLIIH------------------------------------------ RNRNENVKLETLLNLMGAG----------------------------------------- TKEESSLKANELLGIVQSF----------------------------------------- --------------------------------------------------MTFFDSDDDG -MDISGKSTPVRTPSRASSPVKISQLFRP------------------------------- ----------MSTPSLKRSISEISDRISR------------------------------- ----MDSTNLNKRPSLQYSLSSLGSQ---------------------------------- TDDMVTQPVLSKPPSLQYSLSSLSSQ---------------------------------- ----MDSTNLNKRPLLQYSLSSLGSQ---------------------------------- ----MDSTNLKKRPSLQYSLSSLGSQ---------------------------------- ------------------------------------------------------------ ----MDSLNLNKRPSLQYSLSSLGSQ---------------------------------- ------------------------------------------------------------ ----------MNKRIRQKGVRILGSQLD-------------------------------- NDSEGFNDSSQKKSTLKRSLSSLSSQ---------------------------------- -------MVPPRRKKPKYEPVEINSSF--------------------------------- --------MSSKRRDLQRGLSSLSSH---------------------------------- --------MYNKRNRERKDDENRLSKTE-------------------------------- -------MAPPRRKKPKYEPVDINSSF--------------------------------- ------------MPPRKKQCKQQDVSF--------------------------------- -MPPRRKKVKVEVIESSFDEEISSESQESEN----------------------------- VSCAQTLNRLLMGPRRKKTPIYVEDD---------------------------------- -------MVKRSRRTRKTTPNYKEVVPDE------------------------------- ------------------------------------------------------------ --------MERERPSIRRSSSALNLLSSQ------------------------------- LSDISETDLFDALDSAREKCLSRGVKTQ-------------------------------- ------------------------------------------------------------ ----------------ASPRKDKKVKRSS------------------------------- ----------------ITKWSSS------------------------------------- ----------------ISKWNAAS------------------------------------ ----------------ITKWSSS------------------------------------- ----------------ITKWSSS------------------------------------- ------------------------------------------------------------ ----------------ITKWNSS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------INEWNGSSNGNSSS------------------------------ ------------------------------------------------------------ ----------------INEWTEADKARKTDQPLKK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------FDHW-SVPKSQIQTQSI--------------------------- ------------------------------------------------------------ ----------------VVEVSEEEEEDLVEDDETE------------------------- ------------------------------------------------------------ ----------------FDKWKGKNI----------------------------------- ----------------PQPARPPPIQAMPPPRAQPLRK---------------------- ---------------------------------------------RSLRKTLEQLESTSN ---------------------------------------------TSVPSFPYTNLDHVD ---------------------------------------------RPTSPVRRARTTENE ---------------------------------------------RPTSPNR-------- ---------------------------------------------RPTSPVRKARSTEND ---------------------------------------------RPTSPVRKARTIEYE ------------------------------------------------------------ ---------------------------------------------RPTSPVRNARSTERE ------------------------------------------------------------ ---------------------------------------------SKISVKNRKIASING ---------------------------------------------TSPVKKKQQQIGIKR ---------------------------------------------DEISSDSQDSSSFEH ---------------------------------------------RQQIYDRSSRGTITE ---------------------------------------------DVSDESISEFEASEE ---------------------------------------------DEISSDSQGSSFFEH ---------------------------------------------ELVDSLSDDDDESQD ---------------------------------------------QSFSSFSSLDLPEHP ---------------------------------------------SLSEELDEISEDPIA ---------------------------------------------EEIRAFKKPKSQLKT ------------------------------------------------------------ ---------------------------------------------SPTKKRSNTTNSIKN ---------------------------------------------RSPPSFLPRSRDVNQ Y------------------NHVTQENTDGAWYITCSPRNIDEVALHKRKLADVKEAFLSM LTR--------------P-SGERTLPSELQWYDKFSPKRVDDIALHKKKIEEVRYYLEGM SNF---------KGEAVAESSGVNDYNDKQWYEKYQPTNLDQVAIHKRKLQDVREALEAM -------------SPTKI-TPNRKEEEYLPWYEQYQPRTLDEVVIHKRKLKDVTEALENM FLS--------KQDTSSI-LPSINDDGGEQWYEKFKPNCLEQVAIHKRKLKDVQEALDAM CIP--------KRNTVTA-SPNVNDNGDEQWYEKFKPTNLEQVAIHKKKLKDVREALDAM ------------------------------------------------------------ SLS---------KQDVVDTSPNIDENGGEQWQERFKPTCLEQVAIHKRKLKDVREALDAM ---------------------------------------XSQIS---------------- SSR----------------NQGADDTELGNWYDKYRPRRLDEVAIHRNKLEGVRKALEAM STR-----------SYTP-SKNSQSGKFQQWYQKYEPKAVPDIAIHNRKLKDVLGTLESM WSI----------QPSPVKKSQTTINNNQQWIDKYRPKTTSEICINPTKLKQVKESMMKM FSG------------------ANLPETHAEWYQAYEPTTSDELALHKRKLSDVKTILESM FIP-----------SKRQRKQTCTDTFQQQWIDKYTPTRSEDICINPRKLKEVKETLSNM WSI----------QPSPV-KKSETINNNQQWIDKYRPKTINDICINPTKLKQVKDSMMKM FFL------------VPP-SPEKLNKSQVPWLEKYAPQNASEICINPTKLQQVRQLLNNM YQP----------------SRQHQQVQQQQWIDKYRPKNVSDICINPTKLKQVKESLLGM FPP-----------PKKI-KLPPKPSEELQWTEKYRPTSSSQVCINPRKAKEIRDALGSM TTQVQPAKIINDLVPRVT-SNQVEQLQLLQWIDKYAPSKSNDICINPQKLRQVRQLLYDM ------------------------------------------------------------ ETQ--------------M-TVDDSSSDSLCWYEKYSPTNISEVAIHNKKLESVRNELTSM AHF--------NNKSESR-DLNLPLPGSLPWTAKYQPKNASEIAISPKKYTEIYNTILSV LQS----NSRP--RILLLTGPSGCSKSTVIKLLAEQYIPNIRKEYLTAGPYNYSTNRKVI VSG----KSDE--RILLLSGPAGCSKSTCVKLISDEIVPRYRATS----------GLTVS FLP----DAKH--RILLLSGPSGCSKSTVVKELSKVLVPKYRRESNIASLRGTSNPSVVT LNG----NSDS--RILLLTGPSGCSKSTVVTKLADFLIPKYRNSYGMRTTLRNREKTNVV FLP----NAKH--RILLLSGPSGCSKSTVIKELSKILVPKYRQNSNGTSFRSTPNEHKVT FLP----HAKH--RVLLLSGPSGCSKSTVIRELSKVLVPKYRKKSNVTSLRSNSSHSDLT ------------------------------------------------------------ FLP----DAKH--RILLLSGPSGCSKSTVIKELSKILVPKYRQKSNLMSLRGISNDHEVT ------------------RGPN-------LQCFNRGL----------------------- LSG----TSQT--RILLLTGPAGCSKSTVVKLLSAELVLQYRSAARE--------DMHLP ISG----KSDC--RILLLTGPAGCSKSTLIKLLAEELIPKYRTTSLHSLRSQP--AHDVI INK----TSNT--RVLVLSGPSGSSKSTTVKLLAEEL----------------------I IAG----KSET--RILLLIGPAGCSKSTSIKVLSNELVPLYRTNSNIRSELKSE-PAAVL ISG----IDPT--KLLILTGPSGSSKSTTIKVLANEIIPRS---ATSNNFESYMTESTLH INK----TSNT--RVLILSGPSGSSKSTTVKLLAEEL---------------------II LKG----RLPK--KLLVLTGPCGSSKSTTVKLLARELC-----------------GGDI- INH----TSRS--KILILSGPSGSSKSTTIKLLANELLP----------------HQDVF ING----ESRV--RFLALTGPSGSSKSTLVKCLSKELVGGKIGKRQSAQDFSETADSEVV ILN----KSHK--RLLVLTGPAGSSKSTTVKLLADEIIA-SLPDHQLDEYGLLGTSSADP ------------------------------------------------------------ LDG----TSNS--HILLLTGPSGSSKSSVIKHLAHSLIPMYRSSTVGLTGS----NPDLI TSA----VG----RVVILSGPAGSSKSTALNQAIIDVSKLLNK------------SPAKI NYNNNSNLI------------------GQSHMDSFAEYL-RHAKYLTG------------ GREVPNFTEYLTDMS------------SVSPSESFDDFLLQS-KYLIG------------ EYRGDCIVN------------------DVPQMESFSEFL-KSARYLVM------------ EYGNDSILN------------------GQPQTESFAEFL-RQAKYRIG------------ EFRGDCIVN------------------DLPQMESFSEFL-KGARYLVM------------ EFRGDSIVN------------------DLPQMESFSEFL-KSARYLVM------------ ------------------------------------------------------------ EFRGDCIVN------------------DLPQMESFSEFL-KGARYLVM------------ ------------------------------------------------------------ A-RANTYVEYSNDT-------------DAPPLEQFDEFLQQA-KYRIG------------ EYNSDVNVA------------------ETSSLYSFEDFLIQSR-YKVN------------ TVRDAFDSVVV----------------EYDESEDFLKFL-QDCRY--------------- EYDSSNLPV------------------SASKTDHFDNFLTES-KYRIG------------ DWIEYIDTIVT----------------DTPQSKQFSEFL-NDARYRIG------------ V-RDAFDSIVI----------------EYNELEDFGNFL-QDCRY--------------- -FNDSIV--------------------EYQESENFSVFL-QSCRYKNG------------ E---DSKII------------------EYNESEDFLKFL-QECKY--------------- EYSESELL-------------------NIPQPDHFSDFL-DGCRYRVG------------ HWIEYLDGNSVE---------------GTNQSDLFEEFLTDAK-YRVG------------ ------------------------------------------------------------ EYQVDFVPS------------------GSSSISHFKHFLNQA-KYRIG------------ EWSNPAHIY------------------QAPSAQAFHKAVSEYMFLRQD------------ ---------------RNLSLMLVEDLPNVTHKETRR--EFQKLLLQWLYSPEA------- ---------------RNLSVLLVEDLPNVFHESTLK--RFRESILSWLFASD-------- ---------------SNLSLILIEDLPNVFHVDTRN--RFQQLILQWLYSSEP------- ---------------SNLSLILVEDLPNVFHSGTRY--SFQNILLEWLYSSDE------- ---------------SNLSLILIEDLPNVFHIDTRR--RFQQLILQWLYSSEP------- ---------------SNLSLILIEDLPNVFHMGTRH--RFQQLILQWLYSSEP------- ------------------------------------------------------------ ---------------SNLSLILIEDLPNVFHIDTRR--RFQQLILQWLYSSEP------- --------------------------PNIFHTDTRH--AFQKSLLEWLYSPEX------- ---------------PNLAVALVEELPNVFHEETRH--RFNMSLLQWLSMER-------- ---------------NNLSLLLVEDLPNVFHSETRG--MFQKSLLRWLYSNES------- ---------------KSKNVILVEELPNIYHLETLK--KFRDAIRDWIYQDDNGF----- ---------------SNLSVLLVEDLPNVFHSSTRS--KFQKALLRWLFSSQE------- ---------------SNLSIILIEDLPNIFHADILS--KFRGNLNEWVNTDH-------- ---------------KSKNVILVEELPNIYHLETLK--KFRDAIKHWIYQDDNGF----- ---------------S---IVLLEDLPNVYHFETLQ--LFREALRHWINYDG-------- ---------------KKESIVLIEELPNVYHQDTLI--KFRQGLKNWIYQDIL------- ---------------SNLAVILIEELPNVFHPKTLE--SFRRSLASWIYSSA-------- ---------------SNMAVVLIEELPNVFHYETLL--KFRNKIREWIYCNE-------- ------------------------------------------------------------ ---------------QNLSIVMVEDLPNMFHNNTRS--EIRKALLQWLYDSES------- ---------------DCMRVILVEDLPNIMHEGTRM--WFRRAVEEYLNYLPEE------ -------LLPPLIICLTECEL-KPENDNKNFNYIGTDYLFTAETVLGQQILSHPLLKRIK -------RLPPLVICLTECQL---LDSNSTNSSFGIDSTFISETILGKDILMHPLLHRIK -------LLPPLVICLTECEI---PENDNNYRTYGIDYTFSAETVMNKEILIHPRLKRIK -------TLPPLVICLTECEL---ENDSNTFNTFNIDSTFTAETILGKQILSHPRLKRIK -------LLPPLVICITECEI---PENDNNYRKFGIDYTFSAETIMNKEILMHPRLKRIK -------LLPPLVICLTECEI---PESDSNYRTFGIDYTFSSETVMNKEILAHPRLKRIR ------------------------------------------------------------ -------LLPPLVICVTECEI---PENDSNYRRFGIDYTFSAETIMSKEILMHPRLKRIK -------VXPPLVICITECSL-----GNENSQGFGVDYNFTAESVLGREILAHPKSARIK -------ELPPLVICLTECEI------NESNRRFGIDTMFVAETLLTKEVLTHHLLSRIK -------KLPPLVICLTECEV---VTDSQGYNNFNIDTNFIAETVLGKELLSHPLLTRIK -------SLPPLIICLSEIEY----DSNDLRISYSIENNLTVDTLLGKEITGLTQVENIK -------RLPPLVISLTECEI---QSSENRGLAFSIDTHFIAETVIGRDILTHPRLKRLK -------QLPPLVLCLSEIEL---TQEQRNQDYFNIENNLTVDTLLGRELSQRGKVKQIK -------SLPPLIICLTEIEY----DSNDLRISYNIENNLTVDTLLGKEIIGLNQVEIIK -------QLPPLVLCLSEFEY----ETDDQRTGYNLENTMTAETLLGRDLLVSEQVEVIK -------NLPPLVICLSELEYNSNGDNEGFRNSYSIDNNLTVDTLLSKEISKLDQVENIK -------ELPPLVLCLTEVEI---QSEDRNKSFYNIENNLTLETLLGSELLRTTLVQRIK -------TLPPLVICLTDVEY--TSEQGTRDYSYTIDNNLTMDTLLGKELANLAQVEHIK ------------------------------------------------------------ -------NLPPLVICFTECDI-PSDDNITQNYQYSVDTTFTAETVFGKDILQHPKLKRIK -------KLAPLIVVVSENDN---------NEAQSFAESHTVESIFSRDLLDHPRIKRVK FNPINATLMKKHLNIVSHMNAGTLKNNGKWNDVSGYISDVAKNT-GDIRSGISNLQFWAC FNPINATLMTKHLKQIIQKVRREI-PSEKYQRSGTFIKNLASST-GDIRSGIAALQFWCT FNPINNTLLKKHLKLICVDNMALLKKNNKWSKREEVISHIAQET-GDIRSAITTLQFWVT FNPINMTLMKKHLMKLCSKNQSLLEQNKKWSHRTEFVTHLCSNC-GDIRSGISALEFWAK FNPINSTLLKKHLKFICVQNMKMLKEKNKWNKRQEVIDYIAQET-GDIRSAITTLQFWAT FNPINSTLLKKHLKLICVENMALLKENKIWSKREEAINHIAQGT-GDIRSAITTLQFWAT ------------------------------------------------------------ FNPINSTLLKKRLKLICVQNMKMLKEKNKWNKRQEVIDFIARET-GDIRSAITSLQFWAT FNPINTTLMKKHLRSKCQENRKLLIQNGKWNSKDLVIDQLASTT-GDIRSAIANLQYWAT FNAINATLLTKRLRYIAARETQFLPHSKRALVGSYIKELAGRS--GDIRSAIAALQFWCH FNPINKTLMTKYLRRIAMSERQSF-TTGKWSLINEYIGKLAQSC-GDIRSAISTLQFWAT FNSIANRFLKPTINKIIKQE-GIL-KIVNQQILMRFLDEIFQ--IGDIRSIIFNLEMWIK YNPVNKTLLRKHLNAICAQERSSF-APGKWNAKDVFINKITENC-GDLRSAISSLQLWAA FNSIAASFMKKSMNKIVNEERRAF-NGIAKTSINDFSSHIIES--GDIRSAISNLQFWSG FNSIANRFLKPTINKIIKQEGILKIINQQ--VLMRFLDEIFQ---GDIRSIIFNLEMWIK FNPLAHRFLSKTVKRVLKLESLA--------IDESFLNDIYKT--GDIRSVMFNLEMWSR FNKIANRFLKKTINKIIKDEHLIRSIGTTRL--NEFLDEIFK--IGDIRSIICNLEMWVK VLPVAKTFLKKTLGHIVASEKLRIPPS----LTDQVFQPMYES--GDIRSSICNLQFWAM FNSIANRFLKKTIGQLVKSERNVF-NKIPYKELTEFMDEIIK--IGDIRSVIFNLEMWAT ------------------------------------------------------------ FNPINATLLRKYLSQICIKNKHLLMQNNKWSIKDTFIRELSLNS-GDLRSAIATLEFWAT VSSVAKSFLRKPLLEIVLAEAGSKHVSVSSTAVPRKLPCLEVAYVGDIRSAINALEFFHR ----------------------------------SSSNNKISFLRENNVSYFHAIGKIIY ---------------------------------SSFDETNSIFTRESSTSYFHGIGKVIY -----------------------------------SSGELPISTRESTISYFHAIGKVIH -----------------------------------SRHSIPLETREQSISYFHAIGKIIY -----------------------------------SSGSLPISTRESTISYFHAIGKVIH -----------------------------------SSEALPISTRESTISYFHAIGKVIH ------------------------------------------------------------ -----------------------------------SSGNLPISTRESTISYFHAIGKVIH -----------------------------------SSVEVPLDTREESLTYFHTIGKILH ----------------------------------SAGSSGLALGRESSLNYFHAIGKVIY -------------------------------SSLDQEEITLIT-RESSVSYFHAIGKVVF ---------------------------NVKQ-SLTNRISIDSFMRENSINLFHAIGKIIY ---------------------------------SKEYDIPEGKIREQAVSYFQGLGRVLF -------------------------------LSKKGRGEIFNSLRENQLNLFHAIGKVIY ---------------------------NVKQFSSKQKISIDSFMRENSINLFHAIGKIIY ----------------------------------SRSHLSMI--RENSLNIFHALGKIIY ------------------------------NVKSNSSIGLDSYLRENSINLFHAIGKIIY ---------------------------------SPSFMKVSASVRENHISLFHAIGKVIH ----------------------------------NYLKEAKWYNRENQINLFHAIGKIIY ------------------------------------------------------------ ----------------------------------SHSYVTLFTRRE-SLSFFHIIGKIIY ------------------------------STVTSSGATSADYIRPDQVSFFRAMGRVFF GSREFD-------------------------------------NDNDMINNLIASNTGTI GSKDN--------------------------------------ENDRYMINELVDGGT-I GSHNTS-------------------------------------DDNEMINTLFSSANGLL GSHDIR-------------------------------------DDHEMINSLILGSKGLL GSHSTN-------------------------------------NDNEMINNLFENSNNLL GSHSTS-------------------------------------DDNETINTLFSNANGLL ------------------------------------------------------------ GSHSTK-------------------------------------NDNDMINNLFKNSNGLL GSRECD--------------------------------------DNEMXNQLTFNSKSHS GSKDTT-------------------------------------DDETITA---LTSTGHP GSKESE-------------------------------------DDNKMI-NNLLKSSSVV SSSKVN---KNRSKIG---------------NNDDDSDPLDKDDIDYQSIEQVLQSFPEK GSKEIP-------------------------------------NDNQMM-NQLMNSSHMG SSSKYR--------------------------------DLDEEESDYLSIKTVLDNYG-- SSSKVNINNNEEEEK----------------EEEEEGERLDKDDIDYQSIEQVLQLFPEK SSKEFE-----------------------------------GKSSNYNSIAKVIELYPEK STSTVN-------------------------------DQKGNDNIDLKSIEQVLNQYPDK SSSKFA--------------------------------GLDEDTNDYLSIQEVFDGYN-- LSSEFS--------------------------------ELSSDERDYNSVEQVLANY--T ------------------------------------------------------------ GSTEIP-------------------------------------DDNEMINSLFLTARDVL GTKK---------------------------------------DTSQIDHD--------- FNDNFKLGLFENYVTYNKGDI------PLTTALSITDTFSQNDK---------------- ANDTFKLGILENFSKLNKSQF------PLHYAADVVDTLSITDT---------------- SNQDYKMGILENYGTFNKGNF------NISDALTIVNCLSECET---------------- GNDTFKLGLLENYGSFNMGKF------DVKIAAQLTDAFSESDM---------------- SKEDFKLGILENYNTFNKGEF------SISDASSIVDCLSECDN---------------- SNQDFKLGILENYGTFNKGNF------SISDALSVVDCLSECDT---------------- ------------------------------------------------------------ SKQDFKLGILENYNTFNRGKF------SISDASSIVDCLSECDT---------------- ANDNFRLGLLENYSLVNGGQV------PLSNVCEIVDSLSQSDS---------------- GSETFKLGILENYAKFAKGNF------PVDTAATVVEALSTCDL---------------- IGESFKLGLLENYGKFNKQGV------TLEAACDIVSSLSESDL---------------- NMDLLNLSLLENYHIYQDSNY------DLKLASNIVDDLSVNDI---------------- LGDNLKLGILENYGTFNKQQF------PLKCAVDIVDSLSLSDTLHSS------------ NNSLLNLSILENYHIYNDLNY------GIEIASEITNNLSISDI---------------- NMDLLNLSLLENYHIYQDSNY------DLELASNIVDDLSVNDIL--------------- NSDLLNLGLLENYHIFQDSKF------PLQIGAAICDDLSNADI-CPF------------ NKDLLNLGVLENYHIYNDSQY------DISLASCIVDDLSINDLLSI------------- NIGLLHLALLENYAVYNDSQF------DISVAAKIVDKLSLNDT---------------- NNQLLNMAILENYLIYNDAHF------PVECGSAIVDALSLNDL---------------- ------------------------------------------------------------ MSQNFTLGLLENYGKFNSAKL------PIELGSKITDTLSECNS---------------- ----IIGGLLAQWGD------------DLGARNNIVDYL--------------------- -----------------LAYVLES---LEYLIRSVRDKLGAVKSGDGLLH---------G -----------------LRPLEEE---PLYYCLGKVRNISSDVKSSNHSVH--------G -----------------MNTLPES---NEYGLRKVRKTF-RNIAKESHNH---------G -----------------MNRSSES---FEYTVRKTRSLF-STLNDNNNRH---------G -----------------MNGLPES---NEYGLREVRKTF-RNISKQGHNH---------G -----------------MNSLSES---DEYALRKVRKTF-HSIAKESHNH---------G ------------------------------------------------------------ -----------------MNGLPEP---NEYSLREVRKIF-RNISKEGHNH---------G ------------------------------------------------------------ ----------------LHHRGECLEGYSEFALRSVRYSL-LKLKNDRDQH---------G --------INTGRNDGFSRDLPES---LEFGVRKVRETF-RNFGEADSNH---------G ----------IKLGDTGIRSTRIN---LSKAQKSTSRSTSMPPSK--------------L -----------------AQKEGEA---LEFPCRLVRDAF-SKLRDADTKA----ESFSHS -----------------LNNFDEG---KETGIRSTRNQL-RRVSGRQSQR---------M ---------------------------GDIGLRSTRINL-SKAKNLSSKRFKS-MPSSKL ---------------------------GELGLRSTRINL-SRVTQKPMVSK--------L ---------------------------GNVGIRSARVNL-RKVPK---------QGVNKM ------------------FPESIQ----DFGLRAVRSEL-RSVGETPGKT---------Q -----------------LTGEANR----EYAIRSTRQIL-QAIPASSSTRK--------S ------------------------------------------------------------ -----------------FGSNLEL---TEYSARSIRHSLVNHTLDAEKLH---------G ---------------------------FALAVRGITTDI-NFIYQLSETSSI-------G KTYFPREGKIRKLQHVFNFSMDDYNLINFKKY-QSYEQYKTIKLLMGYYGPYIRKKRNYK QANFPREYKMVQEQKRFQFQLQDFIAVEFYKY-HSLWSTKDAVLYGSYFGPEIRKFLSFK TVYFPREWKVRRLQNAFKVQAKDWINVNLYKY-NTVHPFRDVALQLGYYAPLIRKSQGYK GTNFPREWKIRKSINEFKIESSDYINVSLYKY-NESHHFKDIILEYGFYGPYIRSLRNYK TVYFPREWKVRKLQNSFKVQAEDWLNVSLYKY-NAVHSFRNITLEFGYYAPLIRKCQSYK TVYFPREWKVRKLQNSFKVQAEDWVNVSLYKY-NTVHSFRDVSLQFGYYAPYIRKLQSYK ------------------------------------------------------------ TVYFPREWKVRKLQNSFKVQSEDWLNVNLYKY-GAVHSFRNITMEFGYYAPLIRKFQSYK ------------------------------------------------------------ AAAFPREWAVKGHQARFKLQAEDFGLVEYHKY-GQVRRFRDIVLYYGYYTPAIRSLRSFN QTTFPREWKVRRSENNFKIQAGDYQDVTFHKY-HTVHSFKDTALFYGFYSPLIKKRRNFK KMKFPRHLKMIKMMNKTKNQISSYRRYL-----NPQTSFQDLNLIDGYYMPIIYNSQRKT RPNYPRESRVQSLSRGTLLDVNEFAVVELSKY-GNSHCFKDIVLDFAFFAPFIRRRQNFK NVKFPRHFKMIKEYNKTKREIGMYRSVVN----ECHTSFNDLNLIDGYYLPLIYNKQQHN KMKFPRHLKMIKIMNKTKNQINSYRRYL-----NPQISFEDLNLIDGYYMPIIYNTQKQT KMKFPRHFRAMKIRSKTHSQVESYRQYL-----APSNSFQTLNLIDGFYLPLIYNKTRGS KMKFPRHFKMNKMIKKTSNQINSYRKYI-----NPRNSFQDLNLIDGCLIPIIYNKRKTQ PMKFPRHFKMLREANKVQRDISDYVRYIGRPY----VSFQTANLYDGFLLPAIYNSFQYK KVKFPRQFKMVRQYNKTYAMIRSYQRY------IDHELFQNLNLLDGYYLPLIYNKRLKT ------------------------------------------------------------ KAAFPREWKIRKSQDEFKEQAIDYSNVSLYKY-KVSKEYNNIVLYDGYYGPYIRKLRNYK AMNASGKLS-------SADSIEYLLRQLHYLF-NQKNSPK-------------------- KKSLKYFLDSMEKNSSEYKAIINQNLETFMVNEDIDILERIGGELKTVETELELAGGDDE AKSLKYYIDSLKPTTEQYNDYMSKYRRLLTIDDLDIL-ERVGGEMRMMHATSELTTSLDD KNSILYYLKNLPTDSVELKQTLEKFHDTMQIEEDIDMMDRIGGPIESLSVEDGLAPLMDG KKALQHYIESLSNDLKKQTAIMDQNEDTLKVDDSIDILNRIGGNIKAVGTEHLATSEDDS KKYILYYLKNLPSGSSGPKQTMDKFSDIMKVENGIDVVDRIGGPIEALSVEDGLAPLMDN KKSILHFLRNLPSDSLDFKQTTAKLHDIMQIEDCIDIMNRIGGPIGRLSVEDGLASLMDN ------------------------------------------------------------ KKSMLYYLKNLPADSLELKQTMDKFSDLMKIENGIDMMDRIGGPIEALSVEDGLTPLMDN ------------------------------------------------------------ -GKSLRSYIKYLHDQKEIDKLLAMNKESLSIDPSIDFLERLGGDLGHVSLDSSLPPEPSA KKSIGYFLKGSNMDSKECQRLLSRNKDTLVVDETVDVLERLGGDIKTIDTDNEVATVDEG ----------------------------------RYRYNRLGGKFQEVYADDTIPIDEGE RKALEHYVRSL-TNSTERQKALSRIKDIGDLDDSVDFFDRLGGEMSIVGAVQDVIVDNTE ----------------------------------KLKYGRLGGLFKQIVSDGDLPVLEED ----------------------------------KFRYNRLGGKFQEVYADDKIPIDEGE ----------------------------------LLRYNRLGGRLQEVYAGEEVVADDDW ----------------------------------GFRYNRLGGKFQEIYADEDMPLKEEE ----------------------------LRYGTNRYNYNRLGGSFKPLYADGDLPVLESD ----------------------------------RFRYNRLGGRFHEIHADESMGTNEEE ------------------------------------------------------------ -KKSLIHFINSIKDEKRKNYILELNNDTFKIEDNIDFLKRIGDDLGTTETVDDITEVETE --------------------------------------QFGTGNLFKQGIDARRTALETR EREEL--TSINRLQQERQT----------------KMALLQKEEDGGDEILNTNFGFEEN SKSEN--LALTNER---------------------NLEKLKSLQKQSLLDEDPS---TLP DYSNS--DHIENQKKRRDT----------------RLRMLIERYEKNVMMTDGG---SEN EQQIR--RSLDHLMVQRDT----------------KLKRLIEAKEEQELHEEGL---IEG DSNNC--DHLEDQKKERDR----------------RLRMLIDQYERNVMMANDD---LED DISNS--GHIEDQKKQRDK----------------RLRILTERYENNVMMADDG---IED ------------------------------------------------------------ DSSNS--DHLEDQKRERDR----------------RLRVLIDQYEKNVMMVNDG---LED ------------------------------------------------------------ YSSRK--NIYMRAKQLITR----------------REESCPDVFQDNEEASPEGQEFVRD NKSPD-----LIFQRKKKE----------------KLMVLEQQQQQQQQQQYGMDYFDQG VT-----YEYDQFEIDIKN----------------KINLDSDMK-YSEVIDEDM---DNM SSPRR--INALRNKQHLIE----------------GTAEEDTFLDEDMLDPIID---SED IACL---YAQDQFQRDIDD----------------KMKTVQE---DEEILSDPI------ II-----YEYDQFEIDIKN----------------KINLDLDMK-YSQAINEDI---DNM PLMDA--YDQFQMDIGEAR----------------TKRKRKDNIDRSGIANGNV---NGN EGDGII-YEYDQFEIDIQN----------------RINEELEIDNSDDELSDPI---EDS KDAVS--GATDQFQVVIAE----------------KIGQEGDEEEDSMSEDIEN---SDD EESQF--YNRDQFEIDITE----------------KIAEEER---GDYSDQDEL---SEE ------------------------------------------------------------ DERTS--VKSINNKKYQKDY---------------RLVKLKELYDDDDELNDEAYEEEEL KKVDE-KMHANHWTSRQ------------------DIVLFEDFYTSKIRSKTKS---TKA IEDSSDNETENIELDDDASLIEFLSQQPPKVVERSQ------------------------ DNHDFKDDPIVDSDSEPA--IGLEVEEGDSELYEILSQ------------------RPKQ EDVSFNDDPIVDSDNDN---NKTGDDTFGRSDEDES--------------------LYEM DDELLLEDRIIDSDEEDD--EDDSLYDLLTQQEPRS------------------------ EETSFNDDPIVDSDSDNS--NNIGNETFGRSDEDESLC--------------------EI KDTSFKDDPIFDSDDSNI----VNNDIFGKIDEDESLY--------------------EI ------------------------------------------------------------ GEASFNDDPIVDSDDS----NNIGNETFGRSDEDES--------------------LYEM ------------------------------------------------------------ PIEESGEEDFTLDDDSIY--EIFSQKRPVPEQTEGI------------------------ EGNEFDDDPIIDSDQEEL---TLGEDSLYDLLASQP------------------------ SDPIESDDDLEDIGDIGD------------------------------------------ DSFSDDDDELYDLLASQS------------------------------------------ ETDIDSDDEIFNDSIDET-----QIHRLVTQSRSQTHK---------------------- SDPIETDDDLEDVRDITN------------------------------------------ DNYNYNYNDDDDDDDDTL------------------------------------------ QDDSNNNDDDDDVFSSDS------------------------------------------ ELNDDLDDMILKNQNRTFERHRIDKNVGVDQKVSTT-----------EKKMAIRNATTTI ISDSEIEGDQGDDDDEAG------------------------------------------ ------------------------------------------------------------ MNDPIVDSDMGNSDMDDD--DDDSIYEFLSQQKSQQPT--------------QATQATQA ETDTKEEGPIFELTGKPF--TSLASLGDKLDLEDDF------------------------ ---------DKIDDNLSDSDLDDL------------------------------------ TKFNGTQNSINEDVPLSDSDIENL------------------------------------ LSQRQPRNASVVNESLSDSDLEIL------------------------------------ --------SADINESLSDSDLEELDR---------------------------------- LSQRQPRKAPVISESLSDSDLEIL------------------------------------ LSQRKPRNAPAFSESLSDSDLEVL------------------------------------ ------------------------------------------------------------ LSQRQPRNAPVISESLSDSDLEVL------------------------------------ -------------MGLNSESIDLL------------------------------------ ----------LHDESLSDSDLEDL------------------------------------ --VAQSQLQNTHNESLSDSDLENL------------------------------------ ---------NESDAFSSDSELELLLTQGKV------------------------------ --------PRKPTVALTGL----------------------------------------- --------LESEDEFLSDPELDQLILAKNY------------------------------ ---------NESDAFLSDSELELLLTQGKV------------------------------ --SDEIENSTQSDLDFDDDDIDYLISQGKL------------------------------ ----------ELDLLLTQGNY--------------------------------------- DSEEKITDLDNSSDFSDDLQLEMLVSQGRL------------------------------ --------------FLSDPELDVLISQGRL------------------------------ ------------------------------------------------------------ TQATQVAPITNINESLSDSDLEDL------------------------------------ ----------DLMEAMNDSDDEWM------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MKTY-RAKRKYLSES--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EDDVFSSSP ----------------MAVNHVRSKSSN-------------------------------- ----------------MSKYRSPKTKKS-------------------------------- ----------------MKAKKSQRKTGK-------------------------------- ----------------MKPKSIGKKSLNER------------------------------ ----------------MKARKSQRKAGS-------------------------------- ----------------MRAGKSLRTTGN-------------------------------- ------------------------------------------------------------ ----------------MRARKSQRKTGS-------------------------------- -------------LWPMAVKSSKKNGGK-------------------------------- -------------------MAGVKKNRSPR------------------------------ --------------MGLSSRQKLSVNGKSP------------------------------ -------------------------MGSIN------------------------------ ------------------------------------------------------------ -MKRDITQLLSPELSQLSSRNDKKRKPTNL------------------------------ -------------------------MGSTN------------------------------ --------------------MISEGKGKPT------------------------------ ------------------------MTGVNK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MTAP------------------------------ ----------------MAIYRSRKVGKRNS------------------------------ TQSPETSPLQPPNESR------LNIKAAQA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------VSPC------------------ ---------------------GKRLVQSKLNI-----NNETILKCPKCEMKYSPNSIDDV -------------------------IQATLQFK----STPTLVKCPKCSITYSTNSPSDL ---------------------KSNLIQSTLQVNGGS-KSNKLVKCDKCEMSYSSTSIEDR ------------------RKSKPKYVQSVLQL------GSKVIKCPKCEMTYSSTSLTDV ---------------------KPNLIQSKLQVNNGS-KSNKIVKCDKCEMSYSSTSIEDR ---------------------KTNLIQSKLQVNGGS-KSRKLVKCDKCEMSYSCTSIEDR ------------------------------------------------------------ ---------------------KTNLIQSKLQVNGGS-KSNKLVKCDKCEMSYSSTSIEDR -----------------------KLLQSRLQIG----PTTNLTKCTKCGMTYSPSVIDDT --------------------KPTKLLQSRLKFAH---SSATLKKCTECQMSYIIDSPADC ------------------KQKKTRLVQSFFKVSD---KKQKLCRCPDCNMSYFTSIASDI -------------------SQKPQKIQSILALP----SNFKKITCSTCDMTYNPHISQDK ------------------------------------------------------------ ----------------------NKKVQTVLNFPSSSPNASQSTTCPTCGMTYYSHVSKDN -------------------SQKPPKIQSILALP----SNFKRITCPTCDMTYNPHIPQDK ---------------------RTRNVQSVLNIS----PTWTKKVCSTCHMTYNPLVSVDA --------------------PKPKMIQSILAIP----TSSKRITCSTCEMTYNPNIHEDK ---------------------MVKKIQGTLNV------APASTSCKLCGMTYTRNVAEDR -----------------------KKFQSTLNFPNRNNLVSKSTTCPECHMTYYEYISKEK -------------------KHPARKVQSTF-------TAKIPTKCKQCHMSYFSHIKNDV -------------------NNETKYVQSKLQFGK---KESKIVKCPKCEMTYTLGSIDDK -------QKRAKVVKKPAKTKAPV--QMTLSL-----GQTTSTTCKTCGMTYQVAYGPDI ATHKKYHDLHINGRNWSQTWGIPI---HDTTSST----------IIATP--SSSPFKTG- VQHKRYHDLHLNGKRWSQSWGDII---NRVEALKTEKQLKYSMVSEKDK--KVMSFQLP- AIHEKYHTLQLHGRKWSPNWGSIV---YTKRDHSSTVHLSRSTGTITPL--NSSPLKKS- SMHENFHDLHLRGRKWSNKWGSIL---EEESDSR----------LMTPP--LSSPSRSS- AIHEKYHTLQLHGRKWSPNWGSIV---YTERNHSRTVHLSRSTGTITPL--NSSPLKKS- AIHEKYHALQLHGRKWSPNWGSIV---YTKERHSGTVHLSRSTGTITPL--NSSPLKS-- ------------------------------------------------------------ AIHEKYHTLQLHGRKWSPNWGSII---YTERNHSRTVHQSRSTGTITPL--NSSPLKKG- TTHKNYHEMHLKGKKWPATWGLGI---SLPSSDG--------STALTPP--SSSSK---- AEHKKYHDLHLYGKKWLASWGTAI-QDTCSSQYI------------TPP--STSGGNASG AEHEKYHDLHLKGRKWSPNWGIIVSSGSVTDMFSGNATRTKSGPKVLSKGNNTDGSGSGK LLHNKYHTNFINGIPWNYKTDNDV---LIIENFT--------LVETPKL--NSTGKSLKS ------------------------------------------------------------ DVHNKYHFNFINGIPWPTSFCNNV-----LERFI--------VVDHTTG--KAKGTSKSK LLHNKYHTNFINGIPWNYKTDDDV---SIIENFT--------LVEKQSL--NPTGKLKL- SVHKKYHSDFMSGISWTATLGSKS-----LETVT--------LVLLKKS--SKLGQ-LKS TLHNKHHTKFINGVPWNTTNDKDI---SVLENFI--------IIDKTSAVRSTTGK---L AMHTKYHASFINGPPWVSSSDPVR---KIRVVKE-------------------------- ELHMRYHARYNSGIPWPPSLSTKV-----VREFM--------LHRVLEP--KQKGFKRVK NTHKKYHTNFLEGPSWSASSACKT----LKSIQL-------------------------- NAHDKYHDLHLKGRKWSNRWGSLV---RIPTLSN--------IAEITPP--SSSRASVLT SAHKSFHSTALNGPKWKPSVSAVV------------------------------------ KSVNNKNNERIVMIQENKPA-EVKAMLEIMDIVNQELNA-PQDENNFWRKPNAEH----- SQTLYEEDEYIVMISPKKAN-EVKAALDLMSIVNEELNA-PHDENAFWSEVDKSG----- SPSIIHQEEKIVSVRPDKSNGEVRAMMEIMTLVNNELNA-PHDENVIWNSTTEEK----- SDAFDNKNEYIVMIRPEYSN-EVRATLEIMEVVNNELNA-PHDENEFWSTQNGN------ SPSITHQEEKIVYVRPDKSNGEVRAMTEIMTLVNNELNA-PHDENVIWNSTTEEK----- SPSVAHQEENIVLVRPDKPNGEGRAMMEIMTLVNNELNA-PHDENDIWNSTTEER----- ------------------------------------------------------------ SPSITHQEEKIVCVRPDKSNGEVRAMMEIMTLVNNELNA-PHDENDIWNSTTEEK----- RGISNTKAERIVMVRSDHQP-EVRTTLHILDIVNDELHA-PHNENEFWCRPNSN------ NGAKADREDYIVYITPGKTA-EVKAMMEIMYIVNNELTA-PHDENDFWSEEGTSS----- SRTTTKSAEYVVMVSPSNKS-ETRAALEIMNIVNNELSA-PHNENYFWSGIDNDCIDDSR TKTRQTFKGSIICINKSNKR-HIQKVELLLNMVNQELNA--SQDSGQWKKPEFDR----- ------------------------------------------------------------ KSQAASKETLVMTIDRRASK-QVKRVEEILKVVNGELNA-ASDGKA-WQKDHKGP----- TRTRLTVKGSIICINKSNKR-HLLKVELLLNIVNQELNA--SQDSGQWKKLEFDK----- SVTRETKRVVIHTIDKQNKR-QVSKVEEILKMVNTELNA-ADDSKQ-WRLLAFDS----- RSNRNSIKCSIITINKTNKK-HIQKVDTVLAMVNQELNA--SQDSGQWKKSEFDK----- ---RKSISLCFYAVDVSSAR-QVARVETLLEMVNRELNA-PQPSSA-WKDPAKYE----- -SSTVSIKAEVVSVDKNSKR-QIQKAQTILDMVNRELNA-PSDSGS-WKKVECES----- RKGRKNTSVTLISVDKSDSN---DHLKSVMKVVNNELNA--VAEFEHWKYTNTGI----- --TGLPIGDKVVMIQPDNAN-EVKATLEILEIVNNELNA-PHDENDFWSLPNES------ ---VDKSKTYTVYKSRLLSH---PCVSQFLKLVNSELNA---PEPILSSQ---------- ---------QGKAIVYIK-DKKVVGAITVEVLKQ--------------HKCRWMIYETRT -------KSQGKAFIYVK-KNRAVGVITIEYIENT-------------NRGKWMVLDTKA ----------GKAFVYIR-NDRAIGVIIIENLYGGNGEAS--------DRGRWMIYDSRR ----------GKAFAYVK-NGRAVAVITMEIINS--------------NRSRWMIYDSKK ----------GKAFVYIR-NDRAVGIIIIENLYGGNGKTS--------SRGRWMVYDSRR ----------GRAFAYIR-NNRAVGVIIIENLYGCDGSVS--------NRGRWMVYDSRR ------------------------------------------------------------ ----------GKAFVYIR-NDRAIGIIIIESLYGGNGNVS--------GRGRWMVYDSRR ----------GKAFLYVK-EDRAVGVITVELLKP--------------ERCRWMIYEDRS ---------MGRAFVYIK-DGRAVGAISVEYLKEDD------------SRGRWMRVSTRE LSVQTDYKNQGKAFIYVK-NDRAIGVITVEYLAEEE------------KRGCWMILGTKD ----------SKAFVIII-DSKAIGLCTTDTIQP--------------DQGRWMIHKTQS ------------------------------------------------------------ --------IQGRAFIVVI-DGRAIGICTTEPIQDVD------------QQCRWIIHRTQA ----------SKAFVIII-ENKAIGLCTTDTIQP--------------DQGRWMIHKTQS ----------SKAFILVL-DNKAIGICTTDSI----------------NHAQWLILKNQK ----------SKAFILII-EGKAVGLCTTDTIGS--------------NQGRWMIHKSQT --------IPGKVFVAVV-NNRAVGFCVTEPI----------------NSAFWLVCRTQQ ----------SKAFVIVI-NGYAIAICNTDPITNVD------------RQARWMVHRLQT ---------EGKAYLAIA-ARRVVGVCTIEPIVNPE------------LQCRWMVFNTQE ----------GRAFVYIK-NDRAVGVITIETLEK--------------ERCRWMVYSSKS ----------AAVYVYVV-DQRAVGCVLVDRI----------------TKCRHVDIQTGT LVE--HVRPQFTLGISRIWVCRAQRGKGIAEKLLDAARISAIPGQNVDKMKLAWSQPSDS IVP--NVVPDVKLGISRIWVCRNQRQHGIATRLLEVARKKSIYGCIVNKWELAWSQPSQS LVQ--NVYPDFKIGISRIWVCRTARNLGIATKLIDIARENIIYGEVVPRCQMAWSQPTDS IID--HITPSFTLGISRIWVCRTQRSNGIATQLLEAARKNVIYGREVNKHSIAWSQPTES LVQ--NVYPDFKIGISRIWVCRTARKLGIATKLIDVARENIVYGEVIPRYQVAWSQPTDS LVQ--NVYPDFKIGISRIWVCRTARNLGIATKLIDIARENIIYGEVIPRCQIAWSQPTDS ------------------------------------------------------------ LVQ--NVYPDFKIGISRIWVCRTARNLGIATKLIDVARENIVYGEIIPRCQIAWSQPTDS IVD--GVEPRFILGVSRIWVCRTQRNKGIATKLLEAA----------------------- LVP--EVVPRVRLGISRIWVCRKQRGQGIATRLLECVRKYAILGNEVARWEMAWSQPSES IVP--QVSPIVKLGISRIWVCKNHRGEGIALRLLETARKYSIYGTEVAKWELAWSQPSES IVP-NQINKNVVIGISRIWISRKWRQYGLGKKLLNVVLKNSIYSVQLLKNQVAFSQPSFS ------------------------------------------------------------ LVP-NQVNRLIKLGISRIWIAPKWRRYGLARRLLDIVLVHSVYGIVLDKKEIGFSQPSFS IVP-NQINRKVVIGISRIWISLKWRQYGLGKKLLDVVLKNSIYSVQLSKNQVAFSQPSFS IVP--------------------DRK---------------------------------- VVP-KQINKNVIIGISRIWICNKWRQHGLAMKLLQCILKHSIYGVILSKNQIAFSQPSFS IVP-RQENKQAKIGISRIWVAPAWRRCGVALQLLDVTLRYTVYGMRLQKLQVAFSQPSFA VVP-NQVVKTAKVGISRIWVAPSWRRNHLAQILLEVVLTNSIFGTTLNRNEVAFSQPSHS LVP-EQTNSSIKIGISRIWVAPNWRRLGIAQTLLDAVREYTIYGVVLNKHELGFSQPSSS IVA--NIRPNFILGISRIWVCKTERCHGIASALLEAARNHTIYGKPVEKWEIAWSQPTES LGL--KEYPAVM-GVSRMYVSQLFRRTGIVTKLLDLAKSDFIYGMELEKNQVAFTQPSEG GGKLAKKYNGVKH-KSGHILIPCYL------SLMNKAVSRFRTAGWLEKAGYSPWLYLYR GSILAKSYNAAKH-RSGKLLIPCYI------MSKHLAITKFRPANWLQKAGYAPQVFLFR GGKLASKYNGVMH-KSGKLLLPVYI------MKANQAISRFRPASWFEKTKIPPQVYIFR GGKLASIYNGVKH-KSGKLLLPCYI------GRVNPATFKFHTAKWLEKTGYAPHVYMFR GGKLASKYNGIMH-KSGKLLLPVYI------MKVNHSISRFRPASWFEKTKIPPQVYIFR GGKLASKYNGIVH-KSGKLLLPVYI------MKINHSISRFRPASWFEKTKIPPQVYIFR -------------------------------MKVNHSISRFRPASWFEKTKIPPQVYIFR GGKLASKYNGIMH-KSGKLLLPVYI------MKMNHSISRFRPASWFEKTKIPPQVYIFR ------------------------------------------------------------ GGKLATRYNSVRH-KSGELLIPCYI------MSKTVGASRFRPAGWLQRAGYAPQVFVFR GGELAKKYNSVFHEKSGKLLIPCYI------KPCSTAASRFRTAKWLQKAGYAPQVFVFR GGMLAKSFNGVKH-KSGEMLLPVYIE-----TRAEKRMRKFKSEHELIKNNLGPQVFVFR ----------------------------------MVAPARFRTAQWLQKTGFAPQVFLFR GGLLAKSFNGVTH-KSGEILIPVYLEE----------MRKHKTEQDLINLNMAPQVFMFK GGMLAKSFNGVKH-KSGEMLLPVYIE-----TRAEKRMRKFKSEHELIKNNLGPQVFLFR -------------------------------LKSAKKMRKWKSPDELQSLELAPQVFLFK GGMLAKSFNGVVH-KSGEMLLPVYIE-----TRAEKRMRKFKSAEDLVKNDLGPQVFVFR GGLLAKQFNGVQH-KSGETLVPVYLED----LRAEKKMRKHKSEEDLARLNLAPQVFMFK GGLLAKKFNGVTH-KSGELLIPVYLE-----LRAEKKMRKHQSVEELQHEKNGPQVFLFK GGLLSKYYNGKMH-KSGEFLIPVYLELPQ--MRAEKRMRKFKSEADLQRLEMAPQVFMFK GGKLASKYNGVTH-KSGKLLLPCYI------KLKAIGPDRFRPTQWLKSAGYAPQVFIFR GLKVAENWAGTVR---------VYREGE-------------------------------- NLERGQVMYSQLPEYGERNIKTQFKRHQWENKTPSLRRDIWRVMCVVQMPNHQDSVQVYQ NLESGQVLYSQFPTFSWKQIDTNFQRPNWENKKPSTRRDIWKCMAVVDLPDYDKSVKVYQ NLEYGQVLYSQFPNFSQNQLDKLFVRPNWSNRKPSLRRDIWKCMCVVNLQNYQQSVQLYQ NLERGQVLYSQFPQISPVQIDKLFKKVNWDYKKPSKRRDLWKCMCVVNMMDYEKSVNLFQ NLEYGQVLYSQFPNFSQTQVDKLFVRPNWSNRKPSLRRDIWKCMCVVNLQNYKQSVHLYQ NLEFGQVLYSQFPNFSQKQVDKLFVRPNWSNRKPSLRRDIWKCMCVVNLQSYQQSVHLYQ NLEYGQVLYSQFPNFSQKQIEKLFMRPNWSNRKPSLRRDIWKCMCVVNLQNYQQSVQLYQ NLEYGQVLYSQFPNFSQKQVDKLFMRPNWSNRKPSLRRDIWKCMCVVNLQNYEQSVHLYQ ------------------------------------------------------------ NLESGQVIYSQLPTFTERQINKNFYRPNWENRKPSTRPDIWKCMAVVDLASHEESVRLYQ NLESGQVVYSQLPTFTQQQINKVVARPGWENEKPSTRRDIWRCMAVVDLPSCEESVKVYL NLFSGQVLYSQVPAYHENQINQQFLSPNWQNRKPSRRQDLWKIMCVVNFNNYEYAIAAYK NLESGQVIYSQLPVFNQHQIDTLFRRPDWANKKPSTRRDIWRCMAVVDLPNYEQGVQLYQ NLFSGQVLYSQVPAFHQDQIDEQFTRPNWENRKPSRRNDLWRIMCVANFENYEYAIAAYK NLFSGQVLYSQVPAYHENQINQQFLSPNWQNRKPSRRQDLWKIMCVVNFDNYEYAIAAYK NLFSGQVLLSQVPAYHQDQIDVQFPNPNWQDRRPSRRQDLWKIMCIANFNNYEYATAAYE NLFSGQVLYSPVPAYHNDQINQQFVNPNWQNRKPSRRQDLWKIMCVVNFDNYDYATAAYK NLFSGQVLYSQVPGFHQDQIDAQFLRPNWENRKPSRRSDLWRIMCVVNFGSYEYAVAAYN NMFSGQVLYSQVPAFHQDQIDQQFVRPNWENRKPSRRSDLWRIMCVASFKDYEHARAAFR NLFSGQVLYSQVPAYHQSQIDQQFPRPNWENRRPSRRNDLWRIMCVANFDNYEYAVAAYK NLESGQVLYSQLPNFSEKQIKLQFQRPNWANKQPSARRDIWKCMCVVDMPSYEASVQLYQ ------------------------------------------------------------ NLCRLRYMRDVLYREEAQKHRKLNDKGQVWYSGQYRPTYTQEAVADLKESIDKSGSAGPL NLCRLRYLRDVTFSKQAKDMRKKNESGHTWYSSQYRPTYSQEAVADLRECLLKLKDVQSV NLCRLRYLRDVAQHKDNDKLRKKDSNGHVWYSGQYRPTFCQEAVADLRESLLKMFEGNAI NLNRLRHLRDFTFLKQCNDMRRKNEDGHVWYSGMFRPTFSQEAVADLRESLIKMQESPRI NLCRLRYLRDVAQRKESDKLRKKDSNGHVWYSGQYRPTYCQEAVADLRESLLKVFENATI NLCRLRYLRDVTQRKESDKLRKKDSSGHVWYSGQYRPTYCQEAVADLRESLLRVFEGDAI NLCRLRYLRDVAQRKESDKLRKKDSNGHVWYSGQYRPTYCQEAVADLRESLLKVFEGSAI NLCRLRYLRDVAQRKKSDELRKKDSNGHVWYSGQYRPTYCQEAVADLRESLLKVFESSAI ------------------------------------------------------------ NLCRLRYLREVPQRKAAEQLRKRNEFGHIWYSAQYRPTYTQEAVADLRECLLRARGGATV NLCRLRYLRDVALQKQAQEMRKKNEFGHIWYSAQYRPTYTQEAVADLREALSKSTGNGTV GLVDLRKTRDVVQKKEANEMRKKNDDGNIWYSGQFRPTYTQEAVADLTHVIDEFELEGTI NLCRLRYLRDVSQAKHADALRKKNDDGHVWYSAQFRPTYAQEAVADLREALAKARVGRAI GLVQLRQVRDVVQKKEAKALRKKNDEGNVWFSGQYRPTYSQEAVADLSHVIDEFELEGTV GLVDLRKTRDVVQKKEANEMRKKNDEGNIWYSGQFRPTYTQEAVADLTHVIDEFELEGTI GLLQLKKLRQVS--KDANDMRRKNEEGNIWFSGQFRPTYSQEAVADLAHVIDEFELEGTL GLVDLRRVRDTYQRKEANSMRKKSEDGHIWHSGQYRPTYTQEAVADLTHVIDEFELEGTI GLVHLREARDIHLKKEAKAMRKKDDEGNTWYSGQYRPTHAQEAIADLAHVIDEFELENTA GLVQLRQARDVVQQKEAKALRKKNDDGNTWYAGQYRPTYSQEAVADLAHVIEEFNLEGTL GLVDLRRARDIHQKKELKQMRKLNDEGNLWYSGQYRPIYSQEAIADLAHVIEEFELENTL NLVRLRYLRDVTYVKQTNEMRKKNNDGNVWFSGQYRPTYTQEAVADLVESLTKIDSEDKI ------------------------------------------------------------ VWEDMWRMGES-VWEELDIKHRALPKLGIRDEHAMLKQLSLE------------------ HWEDEWRMGDEKYWNPVLLNHTTLERLGSREESAILKELAKEEFARVRQQE--------- YWEDPWRMGDEKYWSSSVLEHKLIDRVGAREESVVLKELAKLESQPADQTE--------- HWEDSWRMGDSKYWDPVLVKHEILKITGAREESTILKELTLEKYHRDSPLI--------- YWEDPWRMGDDKHWNYDVLEHKLIQRVGAREESVILKELAKLESHPTEQTE--------- YWEDPWRMGDDKYWNYGVLEHKLIERVGAREESVILKELARLESQPADQTE--------- YWEDPWRMGDDKRWKFKVLEHKLIERVGAREESVILKELAKLEANSTNQTG--------- YWEDPWRMGDDKHWNYNVLEHKLIERVGAREESVILKELAKLESHPTEQTE--------- ------------------------------------------------------------ HWEDPWRMGDAKHWA-ALVQHQFLPRMAAREESAILKQLAKRAFAAPAPPA--------- HWEDPWRMGDNKYWSPVLLKHTVMDRLGAREESALLKELAKQEFSKLRQQE--------- FWANEWHRGDDKHWRADLVEHDKLPVYDPRHQTVLLDIMAIEAFRENNTSE--------- HWEDPWRKGDEKHWTPLLLQHTVISRLGAREQSSILRELSKLEFAKLRAAE--------- MWESLWRKGEDTHWRSDLVEHDTLPPFNPRDQTILLDELAVEEFANLRQQA--------- FWANEWHRGEDKHWRADLVEHDKLPVYDPRHQTVLLDIMAVEAFRENNTSE--------- FWENEWRKGDEKYWNLDLVEHDKLPVHSPNQQTVLLDVMAMEEFKRQRESF--------- FWANEWHKGDEKYWRHDLVEHQKLPVHNPKHQSVLLDVMAIEAFREKTTET--------- FWESMWRKGEDEHWRADLVEHDSLPAFSPKFQSVMLDEMALAEFAKLRAQE--------- LWENAWRRGEDKHWRLDLVEHDTLPPFNPRDQSILLDEVAVEEFAKLRQAE--------- MWESLWRKGDDEHWPLGLVSHEALPPINPRDQTFLLDDLARQEFAKQREME--------- HWEDQWRMGDEKYWTPILVEHSLMSRVGSREESSILKELAKEAFSKGNVEK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ---------------------------------------------------------MPR ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SSRRGKKREPPAWKKAAGGKAPEGGKGGKGGKGGKGAPRVAMGKGVDVGRDREEERRVLA ---------------------MSRN-----TRRGKGIREQKRD----------DAG---- ---------------------MPRH-----GRRGKLPKGEKLPKK--------EET---- ---------------------MARI-----GRRGKGPKESAVRLD--------GDG---- ---------------------MPRH-----GRRGKLPKGEKLPKK--------EGG---- ------------------------------------------------------------ ---------------------MPRH-----GRRGKMPKGEKLPKK--------EGA---- ---------------------MPRH-----GRRGKLPKGEKLPKK--------EGA---- ------------------------------------------------------------ ---------------------MSRN-----TRRGKGIRDQSQVE---------DVA---- ---------------------MSRA-----NRRGKGPKDQIQL----------NEQ---- ---------------------MTDA----------------------------HSV---- ---------------------MASAEMSRTARRGKGIKDENLD----------DEL---- ---------------------MASSET--------------------------HSA---- ---------------------MTDA----------------------------HSV---- ---------------------MPD------------------------------------ -----------------------------------------------------MSD---- ---------------------MNS-----------------------------HSA---- ---------------------M-------------------------------SSD---- ---------------------M-------------------------------------- ---------------------MGRL-----GKRGKAPLTPF------------HER---- ---------------------MA-------SRRSRSHAVSSAEP---------ESK---- L-SSTPSTVLN--RILSV---------------------------LDLTFERDIGML--- --LHEPSNILN--SMLKS---------------------------LDLTFENDIGLL--- --DNTPSTLLS--SMLKTLD-------------------------L--SFERDIGML--- --DDTPSKLLS--SMLKT---------------------------LNLSFERDIGML--- --DNTPSKLLS--SMLKTLD-------------------------L--TFERDIGML--- ------------------------------------------------------------ --ESIPSKLLS--SMLKS---------------------------LDLTFERDIGML--- --DDTPSKLLS--SMLKT---------------------------LDLTFERDIGML--- ------------------------------------------------------------ --YPTPSHLLS--NVLKS---------------------------LELSFDKDNGVL--- --AHEPSRILS--SMLKTLD-------------------------L--TFERDIGML--- --STTLDDIINE---------------------------------LKLTYDSSVGLL--- --AHEPSRVLT--SILKD---------------------------LDLTFERDIGLL--- --STTLDDIINE---------------------------------LKLTYDSSVGVL--- --STTLDDIINE---------------------------------LKLTYDSSVGLL--- --THAATTTLD--DIINELK-------------------------L--TYDPSVGLL--- --VPLVSTTLD--DIVTELK-------------------------L--SYDSSVGLL--- --TTTLGDIIDE---------------------------------LRLKYDSSVGLL--- --KHSASTTLD--DIINELK-------------------------L--TYDSSVGLL--- --AHSASTILD--DIIDELK-------------------------L--SYDSSIGVL--- --LSTPSSILS--SVLNT---------------------------LELSYDTSTNTL--- --STSPPPTDA--LLLRR---------------------------LQNALTLPNSFLKT- -------------NGN--CVRKVPDYGTLVKLRDELQ-KLHHLFEHI--SQSDQASIDLV -------------NGK--YVRSVPEKPVLQTTKDQLE-NLGKCLEKI--AASDQENLDLI -------------NGK--SVRTIPSKKTLLELQAQLD-SLNEILGTI--AQSDRETIEAL -------------DGR--SVRTVPPRKTLVELQEQLD-GLNKLFGDI--VKSDQETIDAI -------------NGK--SVRSIPNKKTLLELQSQLD-SLNEILGTI--ARGDQETIEAL ------------------------------------------------------------ -------------NGK--SVRSIPSKKTLLELQTQLD-SLNEILGTI--ARSDQETIEAL -------------NGK--SVRSIPNKKTLLELQSQLD-SLNEILGTI--ARSDQETIDAL ------------------------------------------------------------ -------------AGK--HVRAAPDNAMLLNFRGKLE-KLDEVLARI--AIEDQEMVDMV -------------NGK--HVRSVPDKTSLSNLKASLE-KLDKNLESI--VKSDEETLNLI -------------DGD--SIRTIPNISTLTNLNKLLK-NLWNQLDEV--ESIDSDVLNKI -------------NGK--YVRSIPGLPALTSLQANLD-KLETTLERI--LNSDRATIATI -------------DGD--SIRSIPSVNILLNLSKLLT-KLSKDLVEV--EQTDSDILKKI -------------DGD--SIRTIPNINTLTNLNKLLK-NLWNQLDEV--ESIDNDVLKKI -------------DGD--SVRNMPNVNILTNLNKLFQ-NLRKQLSEV--EAVDETVLSKI -------------EGD--AIRAIPNINTLTNLNKLLK-NLWKQLNDV--EGIDDDVLKRI -------------DGA--AIRKIPNLNTLHNLSKLLA-KLAKNLQEI--ERKDNILLERL -------------DGD--SLRTIPNTNTLLNLSKLLN-KLSRELNDV--ELDDDLILAKI -------------EGP--SIGKVPSRNILLNLEKLLT-KLSNELDVV--SDADSMAIIAI -------------TGT--SVEKIPEKKTLIELQKQLD-NLYDVLENV--SNVDNRYIQRF -------------NGIDLSEDARVSVNGLVELQNELR-QIRQRTRGV--LENHKAVIRAI RQIREKRKQVRIKEEEEQEQQQKHKLKLKLKLKDVT--------------KKDASATDDK KE----MREDII--------------------------------------RLEDE----K RK----IRDSKDEKDADNKELKESITDDKDEKEIAE--------------KEKDE----S VKIRNSKNKERDSKKQKQFDLPKGPKAQQQRLKSLPTGPAALV-------KSETSKESSN RK----IRDSKNEKQANDEKQET---------------------------SNADG----Q ------------------------------------------------------------ RK----LRDGKNEKDTGDVK------------------------------QKISN----A RK----IRDSKNEKEANDEKQEI---------------------------PNADR----Q ------------------------------------------------------------ RDARDTARKVEH-SQPRTKETAG---------------------------KKARY----G RG----AKEARKQATELPSGTTN---------------------------VDAVA----S RT----IKESEIKSDSKTSENDK---------------------------KRKNEELTPE KEALEASRPPAV-NNLQEVQPVAVEAQEQA--------------------SEVAQ----S SKNHTLDDEDDDKIDEVDIDDEHQTTKNDRLRTSS---------------QNAAD----E RA------------------------------------------------IKESE----S NAIKSGNRKGDL-TKDNNRKRTI---ADVNKRIVQENGLE----------TLPSD----N EI----LKEKQK-KDDNAADTKD---KINDKK------------------RTADE----M NK----LKNSADGGDDISESSDA---------------------------RKREN----D NL-------GLN--------------------------------------KNEDE----D NK------------------------------------------------ALNID----G KNIDERRNKETL-ENQEEEDKE----------------------------NKGKQ----E DE--TVGRRERKGGKSGGKGVGK---------------------------GKGKG----P PELTEESAKAESPEAKEGPVEAEEDTLSRPKPDDVETVEINTQVEETKVESGKDEVEPSE QKEKEEAEAATNLAA-----------------------------------QNAENDSINK EQSEENLLETHPLET---------------------------IP------GTVE----ND DADQSVSSVGNLIESKPLLTNGNSNEKLNDISQDVQLKDNKEKELSTVISTPLESNDREA HESSTATEETNIIDK------------------GVQSPPKPPPS------NEISGTIEND ------------------------------------------------------------ DEQDKNATPIKEISG---------------EGKQVENLVEPQVF------DKIPDAIKDD DENTAVNKEKNINEK------------------GVQSPPKPPPS------DKIPDTIEND ------------------------------------------------------------ GVERIGTGRGGKGDV-------------------ASNIDEAAPR------LGAHELGKRP DEDAGVVPTKHLNRK-----------------------------------RSLKIEDEED HQDDEDEVPMSATKK-----------------------------------RKIVAAAKEA DDDVSETPRRQLTRK--------------------------------------RSLKVED DDEAVTLSKRRKLNT-------------------------------------LVKVKEEE KKDSKTSENDKKRKN----------------------EELTPPN------HGDEDEMPMS ESGIENLVKRRKPNVVEVKTERHEGEEDREGNASREEKNDNKDK------YMDEKNSNND EADTSEAPKIETDKEFNKE--------ESAKDEYEDEDDDVPIN------IAKKRKLNSD DNEEDESIPLAKRRK--------------------------------------KDTIKSE EEDNEKEIEDENKKR-----------------------------------SFSDAVSDQD PEP-------------------------------------EPEA------EGTSGVKHDL EESVKSEEPVGELIE-----------------------------------NESKENEKQE KQSSSSSSTSSKTAA-----------------------------------AASGGSSQTE EKDAEVKDP---------EATDETKAEEQIDETEKPDTVLKRTHSEISSDVENVGELKVE KLDESSEVV---------------------------SDKRSITEENEETDKRPQD----- VKSIKQAAD-------------------IMAKEEINEDKELQVSQDQPREKRPFD----- RIDLDVDPE-------------KQDELEREPNKVESLTVHDASEKSKKRSVSPTG----- VESIKQAAD-------------------NMAKEEINEDKDLQVHRDQPREKRPFD----- ------------------------------------------------------------ VENIKKAAD-------------------SMAKEEINDDKDLQIYKDRPREKRPLD----- VESIKQSAD-------------------SMAKEEINEDKDLQVHRDQPREKRPFD----- ------------------------------------------------------------ AGNGSGAGE------------QVYAEDVARSASEEDVTAPQRRVGTKKRLLKPDH----- QEELKQEK---------------------------------------------------- DAKEEKDLV-----------------------------------SEADGKVEDEL----- EEDDEGETR---------------------------KHAEKAVPQPRQNEAGELD----- EYENEGDDK----------------------------------NEQEEDTKNKVH----- ATKKRKIIA-------------------------AAKEADDKEEKDLVSEADEKG----- NTNTSFDNY---------------------------NGSDEKVRQHKLEATREEG----- VSSDKSESL------------------------------QESSEIKLKSEESTSE----- IEDLDKAPA-------------------------PSKNSSSGNLEEVVGSVGVVG----- DDDEDSVSL----------------------------AKRRKVSTGTKIKLEQDE----- SDDSENEPL-------------------------------------AKRRQLP------- SLENSADEV----------------------------EPEKEKIDSDNAPVTPIQ--EVE NKDIKMEDV---------------------------------DELPAEKKIEPVK----- DGQEEPVEGEAPPKKIKLNLTEETNDAQFGKPEENEGTEVSKD-----------VDIDKM ----------------------TIEEAEVLSSDGHISKKAK-------------LDIDKM --------SEIT---------NDGTENESMKEPENKKQK---------------VDIDKM --------ASSN---------EPNLKKPRSEEGAQKHT----------------LDTHIM --------SETE---------NRATENENTQRPDNKKQK---------------IDVDKM ------------------------------------------------------------ --------SETT---------HEDTENESTHEPDNKKQK---------------IDIEKM --------SETE---------NAATENERTQGPDGKKQK---------------IDVDKM ------------------------------------------------------------ ------RDGGGM---------EPGSTAADSKSASSSRKKSK-------------VDIERI --------PATP---------NRSHEHADKKAKI--MEKSE-------------TDIDKI ---------------------DEKEEKENLNSKDDPIPPVQ-------------TGNFTQ --------EAND---------NKKNEEGLGVSSKHIDKKSK-------------IEIDRI --------DEIE---------KPDDSNELVNSKDDPTPPVQ-------------IGSYTQ --------EDEI---------DEKEEKENLNSKDDPIPPVQ-------------TGNFTQ --------DMDP---------ENENKKELVNSKDDPVPPVQ-------------SGSFTS --------VKRE---------GEQEEKERLNSKDDPIPPVQ-------------SGNFTQ ---------GED---------EEADEKGKVNSKDDPIPPVQ-------------TGSFTP --------EQTK---------SLIDESEQVNSKDDPVPPEQ-------------SGSFTK --------RDEP---------EKVDGDQNLNSKDDDVPPVQ-------------NGSYTQ NGRSGKRSRRXX---------XNIEEDEKPKEEEDEKNKGD-------------IDVYRM --------LNID---------SDLTTIQTSPPGE--------------------GSPKEY E-----------NDPTVKN------PKSE-FVV---SQTLPL-AAKALGLFNE------E E-----------NDPNIRN------PKSE-FVV---SQTLPA-AAMRLGLFQE------E E-----------NDPSVKN------PKSE-FVV---SQTLPL-AAAALGLFNE------E E-----------NDPSVKN------PKSE-FVV---SQTLPL-AAAALGLFNE------E E-----------NDPTVKN------PKSE-FVV---SQTLPR-AAAALGLFNE------E ------------------------------------------------------------ E-----------NDPSVKN------PKSE-FVV---SQTLPR-AAAALGLFNE------E E-----------NDPTVKN------PKSE-FVV---SQTLPR-AAAALGLFNE------E ------------------------------------------------------------ E-----------NDPTVKN------PNSE-FVV---SQTLPV-AARQLGLFNE------E E-----------NDPSVKN------PKSE-FVV---SQTLPA-AAVSLGLFSE------H D-----------NDTRLKN------PKSE-YVE---PQTLSASAIAELGLFSEEN----N E-----------SDPSVKN------PKSE-FVV---SQTLPA-AAVTLGLFTN------Q D-----------NDTRLKN------PKSE-FVT---SQTLPVEAIAELGLFSEDN----K D-----------NDTRLKN------PKSE-YVE---PQTLSASAIAELGLFSEEN----N E-----------NDTRLKN------PKSE-YVE---PQTLSAEAIADLGLYSEDN----D D-----------NDTRLKN------PKSE-YVE---PQTLSASAIAELGLFSEDN----N S-----------NDTRLKN------PKSE-FVT---SQTLSAETIAELGLFSETN----H E-----------NDTRLKN------PKSE-FVS---SQTLSAAAIAELGLFSEDN----N E-----------NDTRLKN------PKSE-FIS---SQTLPAKAINELGLFSEES----N E-----------NDPSVKN------PKSE-FVV---SQTLPA-AAARLGLFNE------E E-----------KN-----------PKSE-FVD---SQTLPL-SVLKLYDEKTI-----P GLECTGEEFLK---KKYSVAS-YP---------------TTDLSDKL------PGELP-- GLEATGEEYLK---KKYGVVS-YP---------------TNDLKELL------PGELP-- GLESTGEDFLK---RKYNVAS-YP---------------TNDLKELL------PGELP-- GLKSTGEDFLK---KKYNVAS-YP---------------TNDLKELL------PGELP-- GLESTGEDFLK---KKYNVAS-YP---------------TNDLKDLL------PGELP-- ------------------------------------------------------------ GLESTGEDFLK---SKYNVAS-YP---------------TNDLKELL------PGELP-- GLESTGEDFLK---KKYNVAS-YP---------------TNDLKDLL------PGELP-- ------------------------------------------------------------ GLESTGDAYLK---NKYAVAS-YP---------------ANDLKDML------PGELP-- GLESTGEDYLK---KKYGVAS-YP---------------TSGLENLL------PGEIP-- GLETQGREYLK---KKYGVAS-YP---------------ERDLQDLL------PGEIP-- GLESTGEDYLK---KKYGVSS-YP---------------TSDLKEYL------AGELP-- GLETHGKEYLK---KKYGVAS-YP---------------ERDLLDML------PGKIP-- GLETQGREYLK---KKYGVAS-YP---------------EKDLQDLL------PGEIP-- GLETHGTEYLK---RKYGVAS-YP---------------ENDLLDLL------PGSIP-- GLETQGKDYLK---KKYGVAS-YP---------------ERDLQELL------PGEIP-- GLETQGKDYLK---RKYGVAS-YP---------------ENDLKDML------PGEIP-- GLETQGKEYLK---KKYGVAS-YP---------------ENDLLNLL------PGKIP-- GLETQGKEYLK---KKYGVSS-YP---------------EKDLLDLL------PGEIP-- GLESTGEDFLK---LKYSVAS-YP---------------TDDLKELL------PGVLP-- Y---TGEEALK---LKYGVAS-YP---------------TTDLKDQL------AGPIP-- ---------DMDFSCPK----PTNQIQFNTFLASVEKFYREFSDNDIGFLEGKYILPQNL ---------DMDFSKPK----PTNQIQFNTFLSSIEAFYREFNDDDIKFLQNKFIMPQNL ---------DTDFSHPK----PTNQIQFNTFLAFVENFFKDLSDENVKFLKTKYILPDSL ---------DMDFSCPK----PTNQIQYSTFLTSVENFLKYLTEEDAKILKEKYIIPNVL ---------DMDFSHPK----PTNQIQFNTFLAFVENFFKDLSDDNLKFLKMKYIIPDSL ------------------------------------------------------------ ---------DMDFSHPK----PTNQIQFNTFLAFVENFFKDLSDDNLKFLKTKYTIPDSL ---------DMDFSHPK----PTNQIQFNTFLAFVENFFKDLCDDNLKFLKMKYIIPDNL ------------------------------------------------------------ ---------DMDFSKPK----PTNQIQYSTFLSSIDNFFREFTEDDIKFLQTRHIIPQTL ---------DMDFSRPK----PTNQIQYSTFLSSIDNFFREFTEEDIKFLQNRHITPTSL ---------NIDFSKNKP---PSNQVQFTTFQSYIESYFRPYSTEDIKFLKERNVVPPGF ---------DMDFSRPK----PTNQIQYSTFLASIDNFFRELTDDDVKFLKKKYLVPPNV ---------DTDFSKNKP---PTNQVQFTTYQSYIESFFRLFLNDDIKFLSEKNVIPPGL ---------NIDFSKNKP---PSNQVQFTTFQSYIESYFRPYLTEDIKFLKERNVVPPGF ---------NIDFSKNKP---PTNQVQFTTFQSYIESYFRPFNNDDLTFLKERNIIPPGF ---------DIDFSKNKP---PTNQVQFTTFQSYIESYFRHYSNEDLKFLNERNVIPPGF ---------DMDFSKSKA---PSNQVQFSTYQSYIESYFRPFSNDDIKFCNEKFVIPPGF ---------NIDFSKNKP---PSNQVQFTTFQSYIESFFRPFLSEDLELLNERNIIPPGF ---------DIDFSKNKP---PSNQVQFTTFQSYIESFFRQFVPEDINFLNQKHIMPPDF ---------DMDFSCPK----PTNQIQFSTFLSSVDNYFKEYSDEDVKFMKAKNIMPPDL ---------DQDYTRAK----PPNQVQFSTFATAIEPYFRPFSEEDVSVLLQQSI-PLGA QVDSTY----DPEVTPYIIPKLG-QLYTEIWAKEDQEKNIGNT--------SPPSVTDP- QFVKSY----DPEVTPYTIPKLG-PLYTDVWLKEDNNQNIANL--------TPPPISDP- QFDKTY----DPEIKPFVIPKLG-PLYSDIWSKDENDKNSAFKK-------TPPHLNDA- QMDKTY----DPEVTPFVIPKLG-PLYSHVWFKEDDNKNIANT--------SPPPLNDP- QFDKTY----DPEVNPFIIPKLG-PLYTDVWFKDENDKNSAYKK-------PSPYSNDA- ------------------------------------------------------------ QFDKTY----DPEINPFIIPKLG-PLYTDVWFKDENDKNPGFKK-------TPSHLNDA- QFDKTY----DPEINPFIIPKLG-PLYTDVWFKDENDKNPAFKK-------TSPYSNDT- ------------------------------------------------------------ QIQKQY----DPEVTPYIIPKLG-HIYTDVWLKEDNNQNVANL--------SPPPVSDP- QVEKSY----DPEVTPYIIPRMG-PVYTDVWFKEDNNQNIANL--------SPPPLSNP- E-KQGY----DADVTPFIIPKLG-KFYADLWSEEDSTLGSKL---------NSPAFQQP- TVERSY----DPEVTPYIIPKLG-PLYTEIWAKEDNNQNIANL--------SPPPLNDP- D-KQSY----DPNVTPYITPKLG-PFYADVWAEEDASLGSKLNS-------PAFQQPSI- E-KQGY----DADVTPFIIPKLG-KFYADVWSEEDSTLGSKL---------NSPAFQQP- E-KLGY----DPDLSPFIIPKLG-KFYADVWTEEDATLAAKLTS-------TAHYQTGP- E-KQGY----DPDLTPFVIPKLG-RFYADVWTEEDSTLSSKL---------NTPGYQQS- E-KRDY----DPTTTPYLIPKLG-PFYADVWAEEDAALRSKL---------SSPAAPRP- E-KQEY----DPDVSPFLIPKLG-KFYADLWADEDSTLSSKL---------NSPAYQQA- D-FSNY----DPEVTPFLIPRLG-DFYADVWAEEDATLGAKL---------NSPALQHSQ QADKTY----DPDVTPYVIPKLG-PLYSHVWLKEDDNQNIGGT--------SPPSLSDP- TGAPLYATGKDAEISPYLVPPLG-PPYTDAWAAEDAEAGIAAGNAASASRFSPPPKTEL- SSI---LPKK------------------------------------GAAN---------- ISI---LPKK------------------------------------SGND---------- SAI---LPKK------------------------------------SANE---------- SSI---LPKK------------------------------------SAGD---------- STI---LPKK------------------------------------SANE---------- ------------------------------------------------------------ SAI---LPKK------------------------------------SANE---------- SAI---LPKK------------------------------------SANE---------- ------------------------------------------------------------ SSV---LPKK------------------------------------SASD---------- VSI---LPKK------------------------------------SSND---------- SSDSY-KPKG------------------------------------SIEG---------- SSI---LPKK------------------------------------SSAE---------- DSF---KPKG------------------------------------SIDD---------- SSDSY-KPKG------------------------------------SIEG---------- ESY---KAKG------------------------------------SLEE---------- PSDSY-LAKG------------------------------------SIDD---------- PLEAY-KAKG------------------------------------DFEN---------- APDSY-KPKG------------------------------------TFDN---------- HPDVF-KPRG------------------------------------SIEN---------- SVI---LPRK------------------------------------SGSF---------- AEI---EPKG------------------------------------KSED---------- -------------INDTILETE-----DVSCGPLVSRLISAIMKESTQNIDS-N--ME-- -------------ISDGVLDNE-----EVSCGPLVSRLLSAILKDDDIIAPK-EELPT-- -------------LDDNVLETE-----SVSCGPLLSRLLGAILKDDDDKPDL-Q--SS-- -------------INDDMLESE-----EISCGPLVSRLLSAILKEDNVSVHA-TPNSI-- -------------LDDNALESG-----SISCGPLLSRLLSAVLKDDNDKSEL-Q--SS-- ------------------------------------------------------------ -------------LDENVLETE-----SISCGPLLSRLLSAVLKDDNGKSEL-H--SS-- -------------LDDNVLETD-----SISCGPLLSRLLSAVLKDDNDKSEF-Q--SS-- ------------------------------------------------------------ -------------INDDTLETE-----SISCGPLVSRLLSAILKDDSGDSHT-S--KA-- -------------LSDDVLDTE-----EVSCGPLVSRLLSAILKDGYSETDSIKEEADT- -------------LTDEALFTE-----DISCGPLSNRLLSAILSNREGGLSD-E--ED-- -------------LSDDVLETE-----EVSCGPLVSRLLSAILKDELPPNGD-SNIKD-- -------------LDDDNLYTE-----EVSCGPLSNRLLSAILSTHEGRSIE-E--ED-- -------------LTDEALFTE-----NISCGPLSNRLLSAILSNREGGLSD-D--ED-- -------------LNDESLYTE-----NISCGPLSNRLLSAILSTHEAQASM-I--DD-- -------------LTEDRLYTE-----DISCGPLSNRLLSAILSTREGGISD----DE-- -------------LNDDKLLTE-----DISCGPLSSRLLSAVLSVHEAKDKI-QDEGE-- -------------LTDDTLFTE-----EISCGPLSSRLLSAILSNNDGSDDY-E--EK-- -------------LNDDKLYTE-----EISCGPLSNRLLSALLSIPEGRAHL-------- -------------ITDGALETE-----EVSCGPLLSRLLSAVFKGETEMDDI----QQ-- -------------LVDDALESS-----DISCGPLASRLLSALLPDPNKK----------- ----SGTPGHGLD-EIKSEPDHGLPADDKDISKDNDNAYSVEGNSSLAANADSVMTNGDT ----NPTLDSSVS-TPVSELEH-------------------------------------- ----KITRDNEPP-RIKEEDKVSSPINNRTD---GADMSLSQETGPSVRTPDSDIDEDAS ----KKEQEDGSDNEMKDMDDS---------------KSITSVQTPNTEAD--------- ----KIIRDGGLP-RTGGEDDI---QSFRNNNNDTVDMTLSQENGPSVQTPDNDIDEEAS ------------------------------------------------------------ ----KITGDNEVP-KVREEESISSPKDNIND---SIDMSLSQENGPSARTPESDIDEEGS ----KIIRDSEVP-RAGGEDDI---QSPRNNNNDSIDMTLSQ-NGPSVQTPDSDIDEEAS ------------------------------------------------------------ ----DQMDDSTVTFENKTEDIADTVGVKVEGANNTVGAAAGNKNNPSNNATAAGGHHGTN ----DGTSMGDED-AKSVTPAV-----------------AAIAPTPDSE----------- ----APAND-----SKSETKDA-------------------------------------- ----ENDLESAADNDTKASAPN----------------PGLSALTPSSEV---------- ----ENN----------------------------------------------------- ----APAHD-----SKSETKEA-------------------------------------- ----ENNNNNNNN-NNNNSNTNNNNNNDDDDGNKDGDQSVSAKGITNYNKKDKEGTNGKR ----DELSKDSTL-KTEVKDEN-------------------------------------- ----EKMADTEQN-DIKKEEAD-------------------------------------- ----EEGSNEEDP-SSN------------------------------------------- -------------------DDD-------------------------------------- ----EASNNTEVNIKIEGNTAA--------STPGQSKMDGLMEEIPTVEPQQKDETPGSV --------------EIKEEPKD-------------------------------------- VDNDDHNS------WDV--NPLSRSTTSTLPAG---NGW--KIEN-VNIDYPT-----FE -------------------VTPSSSSSYGIFKQ---HGA--IANN-SNIDYVS-----FE FQ------------AKSTGNRDGGSTTSTLPQQ---IGW--ITNG-INLDYPT-----FE --------------DEMLNRLIKNGTTSSLPNA---EDW--EINN-VNLDYPT-----FE FQAKL---------AEN--KGSNGGTTSTLPQQ---IGW--ITNG-INLDYPT-----FE ------------------------------------------------------------ FQTKP---------VAN--KDDNGGTTSTLPQQ---IGW--ITNG-IGLDYPT-----FE FQTKS---------VAN--KGSNGGTTSTLPQQ---IGW--ITNG-INLDYPT-----FE ------------------------------------------------------------ SVSAANNNVNI---FEE--IKLPTQSTSSLPQQ---QGW--KAQD-VSLDYTS-----FE --------------FDE--AKNLTSVTSALPQQ---QGW--RVNT-VNLDYPS-----FE --------------SKS--SLAEEEVATQLNSE---EDY--KLSA-EQNDFQT-----IE --------------DDN--KQALASSTSAIPQQ---QGR--KVNS-VNLDYPT-----FE --------------EEE--NPFEEDVATQLNTG---EDY--KLTT-EVSDFHS-----IE --------------SKS--SLTEEEVATQLNSE---EDY--KLST-EQNDFQT-----IE --LAEVKEEKGGTNSSN--ILLEDEVATQLNST---EDY--RLAT-EPSDYHT-----IE --------------KPS--IISEDEVATQLNSE---EDY--KVVT-EANDFQS-----VE --------------GEE--NLLAEDSATQLDSG---ETF--KVTS-EVSDYFS-----ME -------------------LNLDDEVATQLNSG---EDY--KLTA-EANDFHS-----IE --------------TEA--MLSDEEVATQLDTG---DDY--KLTT-EAPDFYS-----VE LDSAV---------TEEMEELKKSLSRVPEGVLPIQSGW--KAND-VSLDYPT-----FE --------------DENSATPAAAVSSSPPQSPLINPSW--KVAT-AKGDYLT-----LE ERLKRELKYVGIYMNL----------------------------PKDENNPNGEDP---- ERLKRELKYVGIYMNL----------------------------PREEGKT-REDP---- ERLKRELKYVGIYMNM----------------------------PKDENNPNSDDP---- ERLKRELKYVGIYMNM----------------------------PKDE-NSDKDDL---- ERLKRELKYVGIYMNL----------------------------PKDENNPNSDDP---- ------------------------------------------------------------ ERLKRELKYVGIYMNM----------------------------PKDENNPNSDDP---- ERLKRELKYVGIYMNL----------------------------PKDENNPNSDDP---- ------------------------------------------------------------ ERLKRELKYVGIYMSL----------------------------PKDENGT--DDP---- ERLKRELKYVGIYMNL----------------------------PRNEDSSGNDDP---- ERLKRELKYIGIFMNLPTTGESKPKAKQANGRA-----------AKKISASIIDND---- ERLKRELKYVGIYMNL----------------------------PRDDDNNYGDDP---- ERLKRELNYIGIFMNLPNCEEEAKNKLQINGRSV----------KKANNGSIIDSD---- ERLKRELKYIGIFMNLPTTGEPKPKAKQVNGRA-----------SKKISASIIDND---- ERLKRELKYIGIFMNLPTVDDSTKSKPKVQASGRAP--------KRSTQTSIIDND---- ERLKRELKYIGIFMNLPTGEEGKPKAKQTGGRA-----------SKKSTVSIIDND---- ERLKRELKYIGIFMNLQNDDEGK---------------------PKKPGNIIDTD----- ERLKRELKYIGIFMNLPLSKEDSKFKGKQNGR------------PKKAGISIIDND---- ERLKKELKYIGIFMNLPTTREETKLKINGRTL------------KGSNTGSILDTD---- ERLKRELKYVGIYINL----------------------------PKDENNPNGDDP---- QRLKREFTYVGIMDVNKKKQGKRFSKRDDEMDLMDD--------LDDDENNEDLEI---- ---------------------------------DW---LNGREDDEVSAELRQLQATLKQ ---------------------------------DW---LTGREDDEISAELRELQSTLRQ ---------------------------------DW---ITGREDDEISAELRELQTTLKQ ---------------------------------DW---ITGREDDEISAELRELQNSLKQ ---------------------------------DW---VTGREDDEISAELRELQGTLKQ ------------------------------------------------------------ ---------------------------------DW---ITGREDDEISAELRELQSTLKQ ---------------------------------DW---ITGREDDEISAELRELQGTLKQ ------------------------------------------------------------ ---------------------------------DW---LNGREDDEISVELRELQNVLRQ ---------------------------------DW---VTGREDDEISGELRELQNELRL ---------------------------------EW---IKNKEDDEVCAEIRKLQRELKE ---------------------------------DW---LAGREDDEISAELRELQSELKQ ---------------------------------EW---IKNKEDDEVCAEIRSLQKELKE ---------------------------------EW---IKNKEDDEVCAEIRKLQMELKE ---------------------------------DW---IKNREDDEVCAEIRTLQRELRE ---------------------------------EW---IKNKEDDEVCAEIRKLQKQLKE ---------------------------------DW---ILNREDDEICSEIRELQDELKG ---------------------------------EW---VKNKEDDEVCAEIRAHQKELRE ---------------------------------EW---ILSKEDDEVCAELRTLQKDLKE ---------------------------------DW---LTGREDDEISAELRELQNSLKI ---------------------------------DW---VHGREDDEICQQMRVLQKKLRQ VTKRNQLRKKNLIPLVERQLAWQEYSSILDDLNKQLDQAY--IKRIRVPK-----KRR-- VTTKNTKRKAMLLPLLERMLAWQEYCTILDNLDKQVDQAY--IKRIRAPK---NKKKR-- VTKKNQKRKALLIPLVERQLAWQEYSSILEDLDKQIDQAY--VKRIRVPK-----KRK-- VTARNQKRKHILIPLLERQLAWQEYSSILDDLDKQIDQAY--IKRIRVPK-----KRK-- VTKKNQKRKAQLIPLVERQLAWQEYSSILEDLDKQIDQAY--VKRIRVPK-----KRK-- ------------------------------------------------------------ VTKRNQKRKTLLISLVERQLAWQEYSSILEDLDKQIDQAY--VKRIRVPK-----KRK-- VTKKNQKRKALLIPLVERQLAWQEYSSILEDLDKQIDQAY--VKRIRVPK-----KRK-- ------------------------------------------------------------ VTKRNEKRKAVLVPLVEKQLAWQEYISILDDLDKQVDQAY--IKRIRVPK---N-KKK-- VTKKNIKRKAMLIPLVERQLAWQEYSSILDDLDKQVDQAY--IKRIRVPK---N-KKK-- VTSRNRANRKKLIPLVEEHIAYQEYCAILEDLDKQVDSAY--MKRLKGKG---K-KKR-- VTKRNIKRKALLVPLVERHLAWQEYASILDDLDKQVDQAY--IKRIRAPK---NKKKK-- ASVQNRKNKKRLRPIVEEQIAWQEYCTILDDLDKQVDQAY--MKRLKAKN-----KKK-- VVSRNRANRKKLIPLVEEHIAYQEYCAILEDLDKQVDLAY--MKRLKGRG---KKKRL-- VTSRNRANKKKLLPMVEEHIAYQEYCTILEELDKQVDQAY--MKRSKGRG---KKKKI-- VTSRNRANRKKLIPLVEEHIAYQEYCAILEDLDKQVDSSY--MKRLKGKG---KKRKT-- AVIRNRQRKKYLIPILEEQLAYQEYCTILEDLDKQVDQAY--MKRLKAKS-----KKK-- VVSRNRLNRKKLIPIIEEQIAYQEYCTILEDLDKQVDQAY--MKRLKGKS---KKKKV-- ASTRNKSNKKKLIPIIEEQLAWQEYCTILEDLDKQVDQAY--MKRLKAKN-----KKK-- VTKKNDKRKHIIGPLLERYLAWQEYMSILDDLDKQIDQAY--IKRIRVPK-----KKK-- VHKTNQARKRILLPIVKEQMAYQEFRQILEDLDKQVDQAY--LKRIRNPK---SKKKK-- -------------KHHGS--------ATSGS--------ASQ------------------ -------------QYTPG---------PDSLATGSTSQAAIQ------------------ -------------KHHTT--------TSSNVNTGT----TSQ------------------ -------------KHHGS--------GSVVGNSGS----ASQ------------------ -------------KHHTA--------ASNNVNTGT----TSQ------------------ ------------------------------------------------------------ -------------KHHTA--------ASTNVSTGT----TSQ------------------ -------------KHHTA--------ASTNVNTGT----TSQ------------------ ------------------------------------------------------------ -------------KHSAS--------TPVA-NPNSTSQAAIQ------------------ -------------KLNIS--------ATTGSTSQA----ALQ------------------ -------------S-------------------------DVV------------------ -------------QQALA--------SAQSSTSQA----AIQ------------------ -------------KVETA------------------------------------------ ---------------------------------------DVV------------------ ---------------------------------------DTT------------------ ---------------------------------------DAN------------------ --------------KTPE---------------------VTN------------------ ---------------------------------------DVT------------------ -------------KTEVT-----------------------T------------------ -------------KHHHG---------SLSSNVGS----ASQ------------------ -------------QQNNN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ --------------------------LAQ-------------------Q----------- --------------------------AAH-------------------Q----------- --------------------------IAQ-------------------Q----------- --------------------------LAQ-------------------Q----------- --------------------------IAQ-------------------Q----------- ------------------------------------------------------------ --------------------------IAQ-------------------Q----------- --------------------------IAQ-------------------Q----------- ------------------------------------------------------------ --------------------------AAH-------------------Q----------- --------------------------AAH-------------------Q----------- --------------------------TPQ-------------------Q----------- --------------------------AAH-------------------Q----------- --------------------------TPQ-------------------Q----------- --------------------------TPQ-------------------Q----------- --------------------------TPQ-------------------Q----------- --------------------------TPQ-------------------Q----------- --------------------------TAQ-------------------Q----------- --------------------------TPQ-------------------Q----------- --------------------------TPQ-------------------Q----------- --------------------------VAQ-------------------Q----------- --------------------------GTA-------------------V----------- ---------------------------KAANSSLKALLDKRQR----------------- ---------------------------QAANSSLKSLLDKRQR----------------- ---------------------------KAANSSLKSLLDKRQR----------------- ---------------------------KAANSSLKALLDKRQR----------------- ---------------------------KAANSSLKSLLDKRQR----------------- ------------------------------------------------------------ ---------------------------KAANSSLKSLLDKRQR----------------- ---------------------------KAANSSLKSLLDKRQR----------------- ------------------------------------------------------------ ---------------------------QAANSSLKSLLDKRQR----------------- ---------------------------QAANSSLKSLLDKRQR----------------- ---------------------------QALNSGLRALLEKRRR----------------- ---------------------------QAASSSLKSLLDKRRR----------------- ---------------------------QAVNSGLRALLDKRKR----------------- ---------------------------QALNSGLRALLEKRRR----------------- ---------------------------QAVNSGLRALLVKRRR----------------- ---------------------------QAINSGLRALLEKRKR----------------- ---------------------------QAANSGLKALLDKRSR----------------- ---------------------------QAVNSGLRALLEKRQR----------------- ---------------------------QAVNSGLKALLSKRKR----------------- ---------------------------KAANSSLKALLDKRQR----------------- ---------------------------PQERPGLRVLLDKRNR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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---------------------------------------------------WIDNIG--- ---------------------------------------------------WIDNIG--- ---------------------------------------------------WIDNIG--- ---------------------------------------------------WIDNIG--- ---------------------------------------------------WINSIG--- ---------------------------------------------------WINNIG--- ---------------------------------------------------WIENIG--- ---------------------------------------------------WINKIG--- ---------------------------------------------------WIDKIG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -----------------------------------------------PLFD-SPD----- -----------------------------------------------PLFD-KPE----- -----------------------------------------------PLFD-RPE----- -----------------------------------------------PLFD-KPE----- -----------------------------------------------PLFD-KPE----- ------------------------------------------------------------ -----------------------------------------------PLFD-KPE----- -----------------------------------------------PLFD-KPE----- ------------------------------------------------------------ -----------------------------------------------SLFD-KPE----- -----------------------------------------------PLFD-KPE----- -----------------------------------------------KLFP-VAE----- -----------------------------------------------PLFD-RPE----- -----------------------------------------------RLFK-ASE----- -----------------------------------------------KLFP-VAE----- -----------------------------------------------VLFP-PAE----- -----------------------------------------------KLFP-VAE----- -----------------------------------------------KLFP-PAH----- -----------------------------------------------NLFR-PGE----- -----------------------------------------------RLFK-SPE----- -----------------------------------------------PLFD-KPE----- -----------------------------------------------PVFSSSPH----- -----------LMLRIPK-------DSVFP------------------------------ -----------VMKRIPR-------DSVFK------------------------------ -----------LMKRIPA-------ESVFK------------------------------ -----------IMKRIPK-------DSVFK------------------------------ -----------IMKRIPN-------ESVFK------------------------------ ------------------------------------------------------------ -----------IMKRIPN-------ESVFK------------------------------ -----------IMKRIPN-------ESVFK------------------------------ ------------------------------------------------------------ -----------KMKRIPK-------ESVFR------------------------------ -----------VMKRLPK-------ESVFR------------------------------ -----------KMKRVPS-------ESILI------------------------------ -----------VMKRIPK-------ESVFR------------------------------ -----------IMKRVPS-------ESVLQ------------------------------ -----------KMKRVPD-------KSILI------------------------------ -----------IMKRVPG------------------------------------------ -----------KMKRIPS-------ESILI------------------------------ -----------IMKRIPK-------ESIFK------------------------------ -----------IMKRVPS-------ESILV------------------------------ -----------LMMRVPS-------ESVLN------------------------------ -----------GMKRIPK-------ESIFR------------------------------ -----------DMKRVPS-------VSVFK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -----------------------DMDQEED--------DDEAD----------------- -----------------------DMDQEED--------EDEAD----------------- ------------------------------------------------------------ -----------------------DLDQEEE--------EEEGD----------------- -----------------------DLDQEEE--------EEEGD----------------- -----------------------REGVVES------------E----------------- -----------------------DLDQEEE--------DEEAD----------------- -----------------------GESEIDE-------EGDDEE----------------- -----------------------REGAVES-------EQVDDD----------------- -----------------------ETIMIKE-------GEVEAE----------------- -----------------------KDGTVEA-------EQNDED----------------- -----------------------DNVVSEE-----KEAEEEVD----------------- -----------------------QEGTVEQ----ETIDDDNTD----------------- -----------------------GGVVDEG-------DEEDEE----------------- -----------------------DIDQPED-------EDEDAD----------------- -----------------------DLEGSDD--------ESDGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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---------------------------------------VF------------------- ---------------------------------------VF------------------- ---------------------------------------VF------------------- ---------------------------------------VF------------------- ------------------------------------------------------------ ---------------------------------------VF------------------- ---------------------------------------VF------------------- ------------------------------------------------------------ ---------------------------------------VF------------------- ---------------------------------------VF------------------- ---------------------------------------QV------------------- ---------------------------------------VF------------------- ---------------------------------------NV------------------- ---------------------------------------NN------------------- ---------------------------------------SI------------------- ---------------------------------------NA------------------- 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------------------------------------------------------------ -----A-----------QNNMNKEEGLED------------------ELNNKRVSWSKTG -----S-----------NNANGKEEELNETLQNKEE-----------SSTCSSASWSKIG -----G-----------QNTNKDVELN--------------------VLGEHLVSWSKTG -----D-----------QNGNNKDVELAENQ----------------LIGQHPISWSKTG -----A-----------QNTNKDVELN--------------------MLGEHLMSWSKTG -----------------------------------------------ILGEHLMSWSKTG -----A-----------QNTNKDVEFN--------------------------------- -----A-----------QNTNKDVELN--------------------MLGEHLMSWSKTG ------------------------------------------------------------ -----D-----------GNDNNKDEEDMGGLQK--------------MSSTTAVSWSKIG -----G-----------NNGNGKDDELTDSLQNKDE------------MNKGTASWSKTG -----D-----------DDNNENTSPAVDMLTQKSL-----------PKASNLISWSRNG -----E-----------SNGNNKDDELTDSLQNKEE-----------LPKADYASWSKSG -----D-----------AEEAIIQK----------------------PKMSNTISWSKNG -----E-----------STSPAVDMLTQKSL----------------PKASNLISWSRNG -----E-----------DQEPENGPLAAVSKLI--------------QGTTPLISWSKIG -----E-----------TGTSAVDILTQKSM----------------TRTSDLISWSRNG -----N-----------DEET---------------------------MSAGAVSWSKNG -----S-----------TAVDILADKS--------------------TRPSDLISWSRNG -----------------EEEE----------------------------MSDRVSWSKNG -----G-----------QTNTNKDDELTET-----------------ATGENLVSWSKTG -----D-----------DSMFVQ------------------------LGARESISWNRNG LIAYADEQSTYGNLCISFLETINGVNCRFHPPQRYVIHPQHQFFYDISSIHWFSLPGDLA LIAYPDNSTADGNLSITFLETINGTNWKFHKPYNYLIHPHGQFFYDIDFVKWSLLGGELA IIAYSDSQSQDANICLTFLESINGINWRFHTPQRYVLHPQPQFFYNISSIHWFSLPGDLA IIAYSNPNSKDSNLCITFLETVNGTNWRFHPPQKYILHPQPQFFYNISSIHWFSLIGDLA IIAYSDSQSSNANICLTFLESINGINWRFHTPQKYVLHPQPQFFYNISSIHWFSLPGDLA IIAYSDSQSPNANICLTFLESINGINWRFHTPQKYVLHPQPQFFYNISSIHWFSLPGDLA ------------------------------------------------------------ IIAYSDSQSPNANICLTFLESINGINWRFHTPQKYVLHPQPQFFYNISSIHWFSLPGDLA ------------------------------------------------------------ LIAYGDAQSQDGNLCITFLETVNGSNWRFHPPKKYVIHPQPLFFHDLRSMHWGLLNGELA LIAYGDNHSVDANLCITFLETVNGTNWRFHPPKKYVLHPQHHFFYSVTSVHWISLPGDLA FIAYIPPIITKSNLLLTYIKNSDGKKWQLASPEPINIKLENNFLPQLSLVSWGSLNTDLA LIAYADSESTYSNLCITFMETVNGTNWRLHPSRKYMIHPHQRFFHNLRSIFSASHSGELA FIAYAAPELNKHNLNLTYLENVDGKSWQLAKHQGINVRPLSNQTPELRLVSWSNLSTDLA FIAYIPPTITNSNLLLTYIKNSDGKNWQLASPEPINIKLENNFLPQLSLVSWGSLNTDLA FIVYVPPTRTQHNLLLTFLENVDGKTWRLAKPQPIDIKCDNKYLPEISLVSWSTLSTDLA SIAYIPPTSTNTNLLLTYIENVNGVTWQLAKPLPINIKIDNNFLPQLSLVSWSTLSTDLA FVCYVSRGP-AHNLALTYLENTNGRRWQLASSQRLCVKPSDSAMPSVELVSWSNLSTDLA FIAYACPVQHKDNLLLTYLENVNGNSWKLAEPQSISVKLENNFLSELALVEWSYLSTDLA FIAYSGA---GNSIHLTYLENINGREWQLAEPQKFKITGHSVAAGPLSAVSWSNLSTDLA LIAYADSTSQDGNLCITFLETINGTNWRFHPPKRYIIHPHNYFFYDIKSVYWFNLPGDLA IIASIG----DEGVETNLLVCTDGQDWVLTKPTLYAPKSITSFVTPHRAFCWSPSGSDLA VCDELGNMTMLIAGQSPDGPTTLDKLTMQDNVYKIHNHVMQLEPERENTDSKLERKKTKK VSDSVGNLTILAASLNDEGNTTYESLSMQDTIFKVHNKFLHLTPINSYTNSKLERKGTKK VCDELGNMTMLITGQRPDRATTYEKLTMQDNVYKIYNHVMPLKPVDKVKPMNIERKQTRK VCDELGNMTMLIAGQGPDGATTFDKLTMQDNVYKIYNHVMPLHQSTPSIVSRLERKQTKK VCDELGNMTMLITGQRPDRATTYEKLTMQDNVYKIYNHVMPLKPVDKLKPMNIERKQTRK VCDELGNMTMLITGQRPDRATTYEKLTMQDNVYKIYNHVMPLKPVDKLKPMNIERKQTRK ------------------------------------------------------------ VCDELGNMTMLITGQRPDRATTYEKLTMQDNVYKIYNHVMPLKPVDKLKPMNIERKQTRK ------------------------------------------------------------ VCDELGNMTVLAAGQGLNGNGAYDRLSVQDNIFKIHNQVLPLESVPKDATPKVERKHTKK VCDELGNMTMILAGYDKNGSSTLDKLTVQDNVYKFYNQTLPLEDKV---SMKVERKQTKK VSDIYGNFYILLAGVGLLDPNHIPSTITTTSTIKPSFELTSYNHMEIYRDIINPDINSAV VCDEIGNVTVMAAGQTSEGPSTLDNIVIQDNVYKIQNQMATLQTAS--PASKISRKHAKK VADIHGNFYVLLAGVGLLENKDANGSTSNGLSVPPSYELTSYNHMEIYRDIIDPQPTGRM VSDIYGNFYILLAGVGLLDPNHIPSTTTTTSITKPSFELTSYNHMEIYRDIINPDINSIV VSDVYGNFYILLAGVGLLESKDPS----------PSYELTSYNHMEIYRDVINQDMSSPV ICDIYGNFYILLAGVRLLESKDVMS---------PSFELTSFNHMEIYRDIINNDINSPV VFDENGHFYVLLAGVGLLSEENGGNSSNATNTAAPSYELTSYNHTEIFRDRTPGR----- ISDVYGNFYILLAGIGLLEPGS-EKLTVDSSGAAPSYELTSYNHMEIYRDIINQDPALPV VCDHQGSFYVLLAGVGVIDHDTNGTHNGNGQRNGTAYELTSYNQLVTYRDMVGERNE--- VCDELGNMTMLILGQSPNGPVTMDKLTMQDNVYKIHNKLIQLDES-VNSVLKIEKKRTKK IIDTLGSLY-------------------------IYSQYTTLSPITCLRKPPSEELTTPI EYNTTILDFHWLSSSKPVIVSQFCAFDSSINMYRNKAQQLSPHGIFHPPFMKYAGLAIRR EYMTRILDFQWCGNSKPILTPLGAMKQTEPPFYKNHIQNCTPIGVFHPASVKHAFTAIRT EYNTSILEFHWLTSSKSVIVSQFCAFDSSSNAYRSRAQQVPPYGVFHPPFIKYACLAIRK EYNTTILDFHWLSSTKSVVSAQFCALDNASNTYRTKAQQIPPYGIFHPPFMKYACLAIRK EYNTSILEFRWLTSSKSVIVSQFCAFDSSSNTYRSRAQQVPPYGVYHPPFIKYACLAIRK EYNTSILEFHWLTSSKSVIVSQFCAFDSSSNTYRSRAQQVPPYGVFHPPFIKYACLAIRK ------------------------------------------------------------ EYNTSILEFRWLTSSKSVIVSQFCAFDSSSNTYRSRAQQVPPYGVYHPPFIKYACLAIRK ------------------------------------------------------------ EYYSTILDFQWIGNQKPSVAQVAAQRDRTNNIFKNQMHQCPPYGVFHPASIKSACIAIRR EYNTTIMDFQWIGSQKPLIAVQNATRDSSTNTFKNQVQQCLPYGVFHPTSIKSACIAVRR NPGASIVAFKWLNIEKPQIVNKAATRNSSSSIYGYGINQYQPYGVCHPIPTKQACVALRK ESHTSVIEFMWIGTQKPSFAILGARKEPSTSTFKSQVQQCPPYGLYHPTSIKSACIALRR ISMSQIVSFKWLNIFKPQIINKPAVLSLPPFAYTYGVGQHHPHGTCHPISTKQACIALRQ NPGASIVAFKWLNIEKPQILNKAATRSSSSSIYGYGINQYQPYGVCHPIPTKQACVALRK NPEASIVAFKWLNIEKPQILNKPAALSTSSSMYAYGVNQYAPHGLSHPIATKQACVALRR NPGASVIAYKWLNIEKPQIWNKPATRDGNSFMYAYGVNQYQPHGVCHPIATKQAILVLRK -----CVAFRWLGVDKAQMRPKAAAR-SAAGEYSYDVGQHGPTHPAHPIASKQACVALRQ NPGAAIVSFSWLNIEKVQIINKPAALSNSPFVYTYGVNQFQPHGVTHPILTKQACVALRQ -----VVALKWLNVEKNQIIPKPAVLNESSAAYQYGVSSHQPSGLSHPISSKQACVVLRR EYQTAISDFFWLSSSKAVISSQFCVLDSTINTYRNKVQQIPPYGVFHPPFMKYACLAIRK DLNA-IVGFTWVAPEKPVILTNPGLKGYSGISVTYGVSQGLHLGPRIPQGFG-ACIGVTR NGQLDFWYQFSNSKDHKKITLQLFNRSKLQYAKITVNNDNSILITTYSRLTGKLSFYKLF NGMVDFWYQLSNSKDFKKISLPVNQRQNLENASIAMDEDQCFLIGTFSNVSQKINFYKLK NGQIDFWYQFSNSKDHKKITLQLLNRSKLEHAKITMNDDQCMLITTYSKLSKNVSFYKLH NGQIDFWYQFSNSKDHKKITLQLTNRTKLQFAKLTINEDQSMLISTYSKLTQKVSFYKLQ NGQIDFWYQFSNSKDHKKITLQLLDRFKLEFARITMNDDQCMLITTYSKLSKNISFYKLH NGQIDFWYQFSNSKDHKKITLQLLNRFKLEFAKITMNDDQCMLITTYSILSKKISFYKLH ------------------------------------------------------------ NGQIDFWYQFSNSKDHKKITLQLLNRFKLEFARITMNDDQCMLITTYSKLSKTISFYKLH ------------------------------------------------------------ NGYIDLWYQFSNTLDFKKISLQLS-KDKLQYAQIATDKEQCFLIGVFSNVAKSFAFYEVL NGQLDFWYQFSNSKDHKKITLQLSPRNNFQFAKIAMNEDQTLLISVYSNLTSKFSFYKLH NGQFILFYQGEHKVEYHKICCNLTDNISIEKASIGFNNDKQIIVTAWDSLSNDINVYSID GGQLDFWYQFSNSKEHKKITLQLSSQGKFQIGKFAMEDEQTLLVGAFSKLSRKISFYKIL NGECILYFQGEHKVEYHKISIKLQFVI-ITKSSIGFKNDKDVIISAFDAVSNSIKTFLIS NGQFILFYQGEHKVEYHKISCNLTDNISIEKASIGFNNSKQIIVTAWDSLSNDINVYSIE SGAFMLYYQGEHKVEYHKTMVNLNGQLQIDKAAIGFTNDKEIIISAWDSLTNTIFTYLVT NGQLMLYYQGEHKVEYHKISHNLTEEFQVDKAGIGFTNDKQVIITTWDSVTNNISTYSVE NGLFTLYYQGEHKVEYHKLSVSLGGGVHFSHASIGFC-DRRIVVAAYDALTRRVSVFVLA NGQFTLYFQGEHKVEYHKTSVALSDDIVITKASIGFTNDKQIVVTAYDSVTRNISTYSVT NGDLTLYYQGEHKVDYYKVSTKLEGTY-ITHGSLGLTKDKSLVVVSHNGLTGKISMHTIR NGQIDFWYQFSNSKNHKKITLQLNNQSKLEFSKITINEEQYLLLSCYSKIANRLSFHKLH SQVLKLWTQNGPSQPYNLVKLSLNQDI-ISHASFAGTKDHKMLLACYSP-AGAIYLYRIE VDWNVNTAKPVVLNDPSLKIKHILDATVDQTDDEGRILDFTHVHVLAKVAEKDAAPEVLL VDWNVNGST---VNDPSLQLTHIYEMLPETTYKASVLLKLTNMKILSRTPIPNSKPEILL VNWNLTTAKPNVLNDPSLKIQYILSTTLDPTDDEGHVLKLTNLHIVSKSIEKDPSPEILI VGWNVNTAKPSVLNDPTLQIHQVLETTIDQLDSAGNVLELINLHVVSKSLEKDSSPEVLL VNWNLNATKPNVLNDPSLKIQFILSTTLDPTDDEGHVLKLENLHVVSKSIEKDPSPEILV VNWNLNTAKPNILNDPSLKIQYILSTTLDPTDDEGHALKLANLHVVSKSIEKDPSPEILI ------------------------------------------------------------ VNWNLNATKPNVLNDPSLKIQFILSTTLDPTDDEGHVLKLENLHVVSKSIEKDSSPEILV ------------------------------------------------------------ INWNVNTTNQAMFHDPKLTLRHILRVRPDALGPNGELLKLENFHVISKTALPGTRPEILI VNWNVNTSNPNAVNDPSLNLQFLLNFSPDLISSQGEILELEDYQVISRTYDNDSQPEVLM INWGVESAKRQKLDQPRLTLKKLHQMKPIQDGESQSQSELSSIDIISSNPDPKSGLSILI VNWN--TSAQNAVGDPSVQLQHLMEMNPDYLGPHGERITLTDFALLSPTHDKSSRVELVI IDWGVESAQKQKVDPPSLILKTLHEMKPIAESEIGDDIDISSIDIISPSFDADLKLDILI INWGVESAKRQKLDQPRLTVKKLHQMKPNQFEESQSPLELSSIDIISSNPDPKSNLSILI IDWGTESAKRQKTDPPTMHLKLIHQMTPEQ--------GLTSIDIISANPEKSSQASILW INWGTESAKRQKVDAPKLTVKKIHQMKPQEEEQYGQSFELSSIDIISANPDSNSKLSILI VDWGVESAARQRSDPPRLSCTLVQEIRVPADTEHGQSGQFLQNTTTTDNPNMTTSPDVLV VDWGVESAKRQKVDPPKLNVTRILASIPVPAEEEGMDMSLASIDIISAGAEKDSSLDILI IDWGAESALKQKTDPPKLSVEHSYDMLPQPTNEQSQDGTLSSIDSISTSANSESNLDIFI VNWNVNTTNHNQLNDPSLTISHIYEINLDRVDEEGKVLEFVNLQVLSKSVEKDTAPEILL VEWS-------KEEEPKLRATRLLKETLMP--QSGAPADLKLFSIRSNQVSSETEAEMVC AYPESLIKRFKLGQVRDYLGILKPELNTSNENHNQASNRSNLRFLGVLNLHHKVASISSE TYARSIVKRYQITSTSTFLESLSIQVPSQR------ITHYCLKSMGTLELQNLLKEITAE LYSKTLVKRYRLAQTQEYLAILKPDLNIDRNNSTSQSRRYNLRHHTDIVLDKKVILITSE IYKKTLIKRFRLVQTQDFVSTLKPNWKQPPGENVTQSTRYNLQHHTDIKLENKAIYVTSE LYSKSLVKRYRLAPTQEYLVILKPDLNIDRNNSTNQSRRYNLRRHSDIVLDKKVTLITSE LYSKSLVKRYRLTKTQEYLVILKPDLNIDRSNPKNQSRRYNLRHHTDIVLDKKVTLITSE ------------------------------------------------------------ LYSKSLVKRYRLAPTQEYLVILKSDLNIDRNNTANQSRRYNLRRHSDILLDKKVTLITSE ------------------------------------------------------------ SYERSLVRRFQMVLSNVFLSSLGLAITALHNNHSVL--RYSMKHVQDLTFDSKIMDIQSH IYSKSLVKKFHINQSK--LSLSFTSIFSSLGNSNPESPLYSIKHTGDLSFDSKVVEVDSH TYGSSIIYRYALEKSDNPISQAFYNLGVEKKIDWKGSVR--LVFKDKLMRRGQIESIING CYSRSLVKRYELVKSTPQLTSAFGVLNVDSSPSAYE---YSFTGKEGIEFDSAILSVERY SYITTTIYRYILADSQDLVSETFADLGMRKNVSASLIKDYSLVLQDKLTRPGHIQRIETA TYGSSVIYRYALEKSNNPISQAFYNLGVEKKIDWKGESSVRLVYKDKLTRRGHIESVISG TY-GTTVYRYQITDTANLIHEAFVELGRRQGVTGELRSVKTIDLVDKITRLDPIQSIASG TYDSSVIYRYSLDH--AVVSDVFTGLGLQKNVQWQGRESRTITLRDRLIRSGEIESVTAG TYTSSAIHRYRLRHI-DPLHSLGPELNGIFSDSKMQ--FPELVLFDVLRVPGKINQITPC SYASSTIYRYSLSEELELILSAFGELGVRKNVTAPAPTVQTVTLQDKLIRSGTIQSITTA SYNSTHLYQYEVGYADDVISPEFAELGRKKGIQENQKTCPKLILVSRAVRPGVLLSVQAA IYNSSVVKRYRLNPIKNYLLVLNPELTSLGEKALNPPQRYTLKFSGDLLFNQRIRQVSTE VFKGATTNRYELQSHTPDLNSTFYSLGTNDSSASSTTHKTHIISLVETTTSNKIVNIGSQ VLDGFVSFYYRNGEIEIYNQNDWKLETERPQGKFSNIITSILSAGFKYPTINGTVEWIRV DLCISTAFKYDDGHIEIYSRNNWKLQIGTTGGYDKPFIQSMFSVGFKYQDITANVEWSII MFDGFVSFYFEDGTIESYNQNDWKLETERQLGKFKNIIASPLSAGFNYEKLLPSLEWMKV MLDGFVTFYFEDGSIASFNQNDWKLETERQQGKYSNIITSTLSANFQYPGINSTLEWIRV MFDAFVSFYFEDGTIESYNQNDWKLETERQLGKFKNIIASPLSAGFNYGKLLPSVEWMKV MFDGFVSFYFEDGTIQSYNQNDWKLETERQLGKFKNIIASPLSAGFNYGKLLSSLEWMQV ------------------------------------------------------------ MFDGFVSFYFEDGTIESYNQNDWKLETERQLGKFKNIIASPLSAGFNYGKLLPSVEWMKV ------------------------------------------------------------ SLDALVCFRLHNGRFQLYNRHTWAVESETIGGYTKDTIISIFGSGFNYPLLADAIEWCAI ILDSIVTFRLRNGTAPRHNNMTWE------------------------------------ FLDLSFLIIYKDGTVDVVDTTSWQIVNNSNNDYPPKLISNLFDQGFQFPKISKNRLVLAI TSEMLIAFRLRNGETKIYDRTTWKPEQVVSSIQHKDLITSPFSTGIKMSTPLYATEWSII VADSFIVLIYTRGEIDVIDRHNLQIVNNRKDGDTPLTVSTMFDVGFNFPIITRSPIVIAV FLDLSFSIIYKDGTVDVIDTTSWKIVNNKNNDYPPKLISNIFDQGFEFPTISRNRLVLAI PSDMYAVIYYRNGKIEILDAVEWEPVGSK--EYPPTTISTMFDLGYGFPSVEQNQLMMAV FLDYTFSILYKDGTIEVIDTRTLKIQNKITEDTKPSQISSIFDIGFEVPKLDTKPLIMAV LDDSLVLFFRSDGAVYMLREWNAPLVRIDSPFEPPSSVASALDCGYRVPCVN-----VAL LSDYFILLYYLDGHVDVVDRNLMKIVNNSDTNLPPKTISSIFDVGFNFPKIDSSNLIMAV FSDIFVVFNYNDGRVDIMDRRKMDIIDPTKSEMPPHTVSSIFDVGFSFQTPKIIPGMVAY IIDGFITFYLQDGSIQTYNQSDWSLENERRQGKFRDILTSVLSAGFTFPKLTSIVEWATV VYDSIFFAAHEDGILNFRYRGNVSSSTK---GTPFNMFS---DAGYAFTPLGDRPDYICV SPAMAGILYKYRHDDLPQFQPMNIDDVSDKSKDEINAATMAFGYVTSAHRQLSGEDIALA SPSMGGTLIKFLNEPLPVFKSVLNEVITDPIRDQIHATGLALVFVILSHRNFSGEDITIT SPSMCGVIIKQYNKKWPEFYAAAQSNYTDPEKDSINATSLAFGYVKSLHKQISAEDLTIA SPSLSGVLFKQIGKVTPDFLPIIQSNVADPTKDEVNATALAFGFVVSTHRQLANEDFSIA SPSMCGVIVKQYNKKWPQFYAAVQKNYADPEKDSINATALAFGYVKSLHKQISAEDLTIA SPSMCGVIVKQCNKKWPQFYAAAQSNYTDSEKDSINATALAFGYVKSLHQQISAEDLTIA ------------------------------------------------------------ SPSMCGVIVKQYNKKWPQFYAAVQENYADPEKDSINATALAFGYVKSLHKQISAEDLTIA ------------------------------------------------------------ SPSSGGIILKLKCKPQPTFYALEQSVLTDPSRDIVHATAFAFEFVRFNNMIHSGEDLAIA ------------------------------------------------------------ SPTMSSIVYTEIYGETVNLQLKPLERITNSHDLYYTSVAFAHRYAFALYTSTCSDDLLLL SPGLGGILSKLKSQDDLRFDPIAAAVTENADEDIAIAIAFAYAFVCANHQQISAEDLSIA SPNLTSIAYTKINNKDQQLNLQVLEKNISPKELFVTSVGFAFRHSYACYTNSSADDLLAL SPTMSSVVYTEIYGDTVNLQLKPMERITDPQDLYYTSVEIAHRYAFALYTSTCSDDLLVL SPNLTSIVYTEIYGENSHLILKTAEKVVSPKELLITSAGFAYRHAYACYSNTCSDDLVLL SPNSAAVVYTEVFADSPNLKLKPFERTNEQGELYTTAVGFAYCHALALYSSTGSDDLIIL SPNMAALVHLPPGADTVSFSLFQPAPNSEAIPTETTAVAIAHAHAHACYTNSCSDDVVAL SPNLTSVAYADFKGGSTRLNLKVFEKEISPKELFATSVGFAFRHAYACYTNTCSDDLVAL SPTLTARVYAFPGEDSPRLHLQTVSKIVNPKVLFLTSVGFAFCHSYACYSNICADDFIVM SPAMTGVIVKLVGKDEPKFLTVYQTDSSNEKNDSVNSTSFAFGFVAGIHRQLSAEDLSIA SPTCASYVYKTKDG----LKLRIIDNILTVAQMVDSAFVLSLRHSVSCISAVCNDDVMMV CKQHILKIAKIDEKRAKDFTTTLMFNLYNFFNFSPGAPKELMDKIISSRPLQKVMLLQLE IKTHVLRLQELDPKRALNFISMLISTIFGLYGLVLDGTKGTLDKALQSKAVQKILLLQME AKTHILKISSLDKNRAKEFITTLLKSLYAFFNISPDAPKEVMDKIITSRPLQKIMLLQLE CKTHILKILQLDEDRAKKFITTLMTRLFTFFNIVPDAPKEILDKIISLRSMQKVWLLQLE AKTHILRISFLDRKRAKEFITTLLKSLYSFFNISPDAPKEIMDKIITSRPLQKIMLLQLE AKTHILKISSFDKKRAKEFITTLLRSLYAFFNISPDAPKEVMDKIITSRPLQKIMLLQLE ------------------------------------------------------------ AKTHILKISSLDKKRAKEFITTLLKSLYAFFNISPDAPKEIMDKIITSRPLQKIMLLQLE ------------------------------------------------------------ AKTHVFRLQRLSEERAVNFIASVIGAILSLYGIHFDGPKEILEKLLQSKAIQKIFLLQME -------------------------------------SRKTMSTMPT------------- IQSEINRIKDAVDGLGKQLCDSVIIECHKAINFHLDTTKESLDKLLSNASLQKLLSLQLI IKTHLLFIKQRSEARAEAFLKQVISNVYHMFGLTSDASKELKDKLIMSRPIQRAMLLQLE IQSEIKRVSGLLHKILNKFIESIICESHKAINFQLDAGKESVDKLLSNPPLQKLLSLQLV IQSEISRIKKVVDGIGKQLCDLVIIECHKAINFHLDTTKESLDKLLSNASLQKLLSLQLI IEAEIDRVKQTLSKIVKKFIETIISESHRSINFQLDASKESVDKLLSNPPLQKLLSLQHI IQSEAERLRKLIGDEIRKFIGIVITECHKAINFQIDGSKDGIEKLLSNASLHKLLSLHFI ATAEVSRGT-----HNDDLIERTVVEAHKSISFHLNSSKESVDKLLSNPALQKLLSLQLA IQTEIVRLQILLQKIIKKFVESIVSESHKAINFQLDANKESVDKLLSNPPLQKLLSLQLV IQQDILRVTKILRKVVTKFIESIICESHKAINFQLDAGKESVDKLLSNPPLQKLLSLQMA CKTHLMNISKDNPERGKSFITSLISCIYSFFNITPDAPTEILDKMISSRPVQKAMLLQLE MRREIQRVSKLAPALETQFPLLLLAESHKAINFSLDLKDHQMDKIMINPSLQRLLTMQTV LGSIFTDENTCEMARVILYLKNVSFALQFAIEQMTNSTNSSNPPAFSKQDLVHSLIPVTK MGPHIINKNIYSVGYIAMKLRNMNIAVQAMIQHTSNISMLPN--AFSKQDLIYSVLPSAK LGSCFSHENIEEMARVILYLKNVLFAFHFAIEQISNNSNQQQNPIFSKQDLIHSLIPVAK LGNCFERSSIDEMARSIFYLKNVLFALHLAIEQMSNDSSIQQNSAFSKQDLIYSLIPAVK LGSCFSQENIEEMARVILYLKNVLFAFHFAIEQISNNSNQQQNPIFSKQDLIHSLIPVAK LGSCFEHENIEEMARVILYLKNVLFAFHFAIEQISNNSNQQQNPIFSKQDLIHSLIPVAK ------------------------------------------------------------ LGSCFSQENIEEMARVILYLKNVLFAFHFAIEQISNNSNQQQNPIFSKQDLIHSLIPVAK ------------------------------------------------------------ LGSHLKNKNVYSMAYASMKLRSINLAVHAMIQH--TAVVNSLPNAFSKQDLIYSLIPSVN ------------------------------------------------------------ LGEFQQNYVVPDIAWIVLNLRSASLGIMFTLSSIYRQVSKKKPSSITRGECIMSIIGNFK LGGTFENSNVYNMSRTAMSLRNILFAIQVLIHH-GATMNLQQPSAFSKQDLIYSLIPCAK LGELQNDHIISDIAWIVLNLRSTSFGIMFLLSSIYRQISKIETN---------------- LGEFQQNYIVSDIAWIVLNLRSASLGIMFTLSSIYRQVSKKKPSSITRGECIMSIIGNFK LGEAQGNTVMSDIAWLILNLRSTNFGIMFTLSSIYRQISKKKPSSITRGECILSLIGNIK LGEVQQNHQASDINMIILHLRSTSLGIMFSLSNIYRQISKKKPSSINRGECIISLLGSFK LGELHSNSTIRDVAWIVLNLRSTSFAIMFSLSSIYRQISRKKPASTVRAESIVSLVGSVK LGELQDNSIVSDIAWIVLNLRSTSFGIMFLLSSIYRQISK-------------------- LGELQDGKLISDLAWIVLNLRSTSFGIMFSLSSIYRQVSKKKPSSVARAECIVSLIGSVR LGSSFKNENIYEMARVVMSLRNVYFALQFAIEQLSGSNAAQLTNAFTKQDLVHSLIPIAK IGTQHGRNVTSRLSWCFLNLRLVSFSLTFTLRAIGQQKPGVAPNHAMRIHYLMSLSGLKR WFVKFITYLIQQILILTNDPENPDNRLVLGVFGAKIPRTLILTILKEIKNVTAIITKFPE WIITFISFVTQQLILKVNNVPDSDESLLISLFGSRIIRHLVSKVIRELTNIANLMIKFPE WFVKFVTYLIQEILILINDPTNEDYTLVHGIFGAKMSRTLILSILNEIKKVTQIVAKFPE WFVKFITYLIQEMLILINNPPTKPNTLVIGILCAKIPRVMILSVMDEIKKIIQIISKFPE WFVKFITYLTQEILILINDPTNKEYTLVHGIFGAKMSRTLILSILNEIKKVTQIVAKFPE WFVKFVTYLIQEILILINDPTNKEYTLVHGIFGAKMSRTLILSILNEIKKVTQIVAKFPE ------------------------------------------------------------ WFVKFVTYLTQEILILINDPTNKEYTLVHGIFGAKMSRTLILSILNEIKKVTQIVAKFPE ------------------------------------------------------------ WFVSFVTFLTQQLIMLVNNPMDNTHSLVLGILSCITTRHLMLKVILELKNMIGLITKFPE -------------------------------------RHYLTX----------------- WLIDLLVYLNQELLQLIYVKNNFLNSIVLPLILNKVSRLFLMYAISAMGRTHEILKKLHK WFVKLVTFLTQQMIVLINKPEDQENTLVLGILSSKMTRQLLLSVLSEIRKIIHLVTKFPE ------------------------------------------------------------ WLIDLLVYLNQELLQLIYVKNKFLNSIVLPLILNKVSRLFLMYAISAMGRTHEILKKLHK WLIDLMAYFNQELMQLTYFKNDSRSSIVLPVILSKVPRLFLMYAISSMGKTHEILKKLHK WLIDLLAYLNQELLQLTYMKNSNLSSLAIPIIMGKVPRLFLVYAITSMGRTHEILKKLHK WLIDLIVYLNQELLQISLSKDNPDNSVTLPLIMSKVPRLFLMYAISSIAKTHEILKKIHK ------------------------------------------------------------ WLIDLIIYLNQEFNQLANSKGDPSISVVLPIVLSKVPRLFLMYALSSIQKTHETLKKLHK WIVKFVTCLVQDLLILINNPGINDSKLVYGVLGARIPRALILSILTEIKRVTQLITKFPE WCLDFAAYLCQELLAASNEGPSYFQHVALPMVMARSSRMLLMYSWRGIRSLDTILMQKPG TNYPILNESSTYLKMLLIESPINFEKFETFLMDVNNKLSAFSEQQPSIMREPTLLVRSVP IAFPILNESSQFFRKVINDCTVNLDLFETFLSEFGSKINELDQNTVQQKYEAEFLIKTVP NSYPILNESSTFLKLVLSESPVDFEKFETFLVDVNNKFIALSEQQPSQEREFSLLVKAIP NSYPILNESSHFLKLVLDDSPVNFEKFETFLVDVNNKFTTFSEQQPSQGREPSLLVNAIP TSYPILNESSTFLKLVLSESPVDFEKFETFLVDVNNKFIALCEQQPSQEREFSLLVKAIP TSYPILNESSTFLKLVLSESPVDFEKFETFLVDVNNKFIALCEQQPSQEREFSLLVKAIP ------------------------------------------------------------ TSYPILNESSTFLKLVLSESPVDFEKFETFLVDVNNKFIALCEQQPSQEREFSLLVKAIP ------------------------------------------------------------ TTYTVLNESSRFLRKALGDSPVNLEKFEVFLNEINNKFLSLLDDHGSMDREPSFMVKAIP ------------------------------------------------------------ DLFAPMKESLNRYFSISNNSPITVNLFESYLRECDALLNKEVPQKIALKFEQKLLIKGIS TTFPILNESSIYLRKVLSDSPVNFEKFETFLADVNYKFTSLSEQQTSTIKDSYLIIDGIP ------------------------------------------------------------ DLFAPMKESLNRYFSISNNSPITVNLFENYLRECDALLNKEVPQKIALKFEQKLLIKGIS DLFKPMKESLNRYFTIFNNAPLTLNLFENYLRECDALVTKEMATKGSLKIEQSLVFGIIP DLFTPMKESLNRYFSIYNTAPITVNLFENFLRECDALCTKELSAKFALRCEQKLVCQGLP DLFTPMQEALMRFFGTCGSSPLNLNVFENFLRDCDTSTSKDLAARAPLQLEHQLFCIGIP ------------------------------------------------------------ DLFQPMKEALNRYFTTCANSPLQISLFESFLRDTDAVIAKEISQNPQLRVEQKLVFQGIS NTFPVLNESSAFLKMILNESPVSFERFETFMIDINNKFSSLNEQEPSTKREPSLLVKAIP TETQEAGLASQRQRELSHFTPISMTFFEQLFNVIDSHTKQVAENVERLGLEQQLLFQGIP NELNKITEFLLQYSSNVISHADASAIYFSDTSGLRISCDTYDRFSLSLKRCNRCGAVTIP DSLPEFDSILRATTMSLLPNINLSTVFFTDTSFLNLCWETSEHVDRSIKKCCRCGTFTVD PEFSKVGDFLLQYANNVISHANAAAVYFADTSGLKISNTTCDKLSISLKRCSRCGSVTIS LDSIKMYDFLLTYSNNVISHVDAAEIYFCDTSGLRISNMTCDQLSLSLKRCRRCGSVTVG PEYAKVGDFLLQYANNVISHANAAAVYFADTSGLKISNSTCDKLSISLKRCSRCGSVTIS LEYAKVGDFLLQYANNVISHANAAAVYFADTSGLKISNTTCDKLSISLKRCSRCGSVTIS ------------------------------------------------------------ PEYAKVGDFLLQYANNVISHANAAAVYFADTSGLKISNSTCDKLSISLKRCSRCGSVTIS ------------------------------------------------------------ PALGHVREFLLSFAGSLLAQTNLAEVFFASTHNLRIFDHSSEWVDLVIKRCVRCGCVTVA ------------------------------------------------------------ NTIIELSNMILDRYSIISRETKLSELMFYDTDWLNIGINSDSSTSAKLRVCTRCRAVSLV EQVSHLKDFLLSYSNTVISHIRPAEVYFSDTRGLRIFASSKEAISEKLKRCCRCGAVTVS ------------------------------------------------------------ NTIIELSNMILDRYSIISRETKLSELMFYDTDWLNIGINSDSPASPKLRVCTRCRAVSLV SEVQDLAKTLVERYSIIARESKVPDLFFYDTEWLNLGNEGVDALRIFVRRCTRCRSVSLV DEFIEVAQILLDRFTLSSREIKVAELISYPTEWLDIGVMYDEGEDLKLRQCTRCRAISSV SPLISVAITMTDHHYAISRDSKLSELFFYNTDWIDAGVGGVSTMGVSIRKCTRCRAVSLI ------------------------------------------------------------ EEYIPIATAVVGKYANISLDMKVSELFFYDVDWIGVGIQLRKVVIKGVRKCTRCRSVSLV PEYTKICDFILTCTKSILSHIDPAFVYFTDTSGLGISKESYDTFTLNLKRCCRCGCITIS QQFLPLAKRCVDEFDKFRKTNDLSPLYFYNVSWLGLDEHCLRKFIQELRVCQRCAGTSVF TNKTRRWPTMYTRMCICLGMLYEL GQNTKRWTALYYRNCHCTGLLYEI GDKTKRWPTMYTRLCICSGMLFEM KNKTRRWPTMYTRNCICSGMLYEL SDKTKRWPTMYTRLCICSGMLFEM SGKTKRWPTMYTRLCICSGMLFEM ------------------------ SDKTKRWPTMYTRLCICSGMLFEM ------------------------ KNNTKRWTALYSRYCQCTGLLYEL ------------------------ GDVTGLWTMVFQRTCMCGNAWVNV KDNTKRWTSLYSKICICSGFLYEL ------------------------ GDVTGLWTMVFQRTCMCGNPWVNV TDPLGLWTMVFQRTCICGNAWVNE TDISGLWTMLFQRNCNCGNPWITN ADPLSLWTMVFQRTCICGSAWVNC ------------------------ NDPLGLWTMVFQRSCICGSIWINT GDKTKRWPTMYARVCICSGYLYEL VDSSTHWTFAFQRNCWCGGMWIPE