Mercurial > repos > proteore > proteore_build_protein_interaction_maps

comparison test-data/Nodes_biogrid_from_Rattus_Hameza_dataset_geneID.tsv @ 2:99f6a94c1ade draft

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planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
author proteore
date Fri, 28 Jun 2019 05:06:57 -0400
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1:0a85d709c4ae 2:99f6a94c1ade
1 Entrez gene ID Official Symbol Interactor Present in user input ids ID present in Biogrid Rat Pathway
2 25 ABL1 False True NA
3 81 ACTN4 False True NA
4 142 PARP1 False True NA
5 156 NA False True NA
6 160 AP2A1 False True NA
7 176 NA False True NA
8 207 AKT1 False True NA
9 273 AMPH False True NA
10 310 NA False True NA
11 366 NA False True NA
12 627 NA False True NA
13 640 NA False True NA
14 657 NA False True NA
15 658 NA False True NA
16 661 NA False True NA
17 673 NA False True NA
18 695 NA False True NA
19 815 CAMK2A False True NA
20 818 NA False True NA
21 857 NA False True NA
22 921 NA False True NA
23 1020 NA False True NA
24 1048 CEACAM5 False True NA
25 1147 CHUK False True NA
26 1326 NA False True NA
27 1457 NA False True NA
28 1742 DLG4 False True NA
29 1759 DNM1 False True NA
30 1956 NA False True NA
31 1969 NA False True NA
32 1978 NA False True NA
33 1983 NA False True NA
34 2054 STX2 False True NA
35 2060 EPS15 False True NA
36 2257 NA False True NA
37 2287 NA False True NA
38 2321 NA False True NA
39 2534 NA False True NA
40 2569 NA False True NA
41 2997 NA False True NA
42 3005 NA False True NA
43 3053 NA False True NA
44 3091 HIF1A False True NA
45 3337 DNAJB1 False True NA
46 3551 IKBKB False True NA
47 3897 L1CAM False True NA
48 4133 NA False True NA
49 4137 MAPT False True NA
50 4155 NA False True NA
51 4215 NA False True NA
52 4430 NA False True NA
53 4690 NA False True NA
54 4692 NA False True NA
55 4792 NA False True NA
56 4908 NTF3 False True NA
57 4915 NA False True NA
58 5156 NA False True NA
59 5340 NA False True NA
60 5414 NA False True NA
61 5467 NA False True NA
62 5481 NA False True NA
63 5518 NA False True NA
64 5580 NA False True NA
65 5604 NA False True NA
66 5638 NA False True NA
67 5829 NA False True NA
68 5998 NA False True NA
69 6300 NA False True NA
70 6330 NA False True NA
71 6449 NA False True NA
72 6477 SIAH1 False True NA
73 6622 SNCA False True NA
74 6721 NA False True NA
75 6769 NA False True NA
76 6804 STX1A False True NA
77 6809 STX3 False True NA
78 6810 STX4 False True NA
79 6857 NA False True NA
80 6885 NA False True NA
81 7006 NA False True NA
82 7041 TGFB1I1 False True NA
83 7157 TP53 False True NA
84 7265 NA False True NA
85 7266 NA False True NA
86 7528 NA False True NA
87 7704 ZBTB16 False True NA
88 7867 NA False True NA
89 7874 NA False True NA
90 7881 NA False True NA
91 8416 NA False True NA
92 8514 NA False True NA
93 8550 NA False True NA
94 8573 NA False True NA
95 8576 NA False True NA
96 8894 EIF2S2 False True NA
97 9014 NA False True NA
98 9040 NA False True NA
99 9379 NA False True NA
100 9454 HOMER3 False True NA
101 9495 AKAP5 False True NA
102 9616 NA False True NA
103 9962 NA False True NA
104 10000 NA False True NA
105 10013 HDAC6 False True NA
106 10018 BCL2L11 False True NA
107 10110 NA False True NA
108 10116 NA False True NA
109 10152 NA False True NA
110 10243 NA False True NA
111 10278 NA False True NA
112 10572 NA False True NA
113 10963 NA False True NA
114 11651 NA False True NA
115 11674 NA False True NA
116 11740 NA False True NA
117 11747 NA False True NA
118 11758 NA False True NA
119 11792 NA False True NA
120 11842 NA False True NA
121 11843 NA False True NA
122 11946 NA False True NA
123 11950 NA False True NA
124 12034 Phb2 False True NA
125 12043 NA False True NA
126 12346 NA False True NA
127 12349 NA False True NA
128 12416 NA False True NA
129 12461 NA False True NA
130 12468 NA False True NA
131 12540 NA False True NA
132 12631 NA False True NA
133 12995 NA False True NA
134 13211 NA False True NA
135 13628 Eef1a2 False True NA
136 13644 Efs False True NA
137 13665 NA False True NA
138 13682 NA False True NA
139 14182 Fgfr1 False True NA
140 14265 NA False True NA
141 14400 NA False True NA
142 14406 NA False True NA
143 14751 NA False True NA
144 14811 NA False True NA
145 14812 NA False True NA
146 14813 NA False True NA
147 15288 NA False True NA
148 15289 NA False True NA
149 15354 NA False True NA
150 15381 NA False True NA
151 15382 NA False True NA
152 15384 NA False True NA
153 15387 NA False True NA
154 15441 NA False True NA
155 15526 NA False True NA
156 15568 NA False True NA
157 16211 Kpnb1 False True NA
158 16647 Kpna2 False True NA
159 16649 Kpna4 False True NA
160 16906 NA False True NA
161 17089 NA False True NA
162 17192 NA False True NA
163 17220 NA False True NA
164 17448 NA False True NA
165 17920 NA False True NA
166 17938 NA False True NA
167 17999 Nedd4 False True NA
168 18102 NA False True NA
169 18148 NA False True NA
170 18150 NA False True NA
171 18477 NA False True NA
172 18521 NA False True NA
173 18648 NA False True NA
174 18674 NA False True NA
175 18795 NA False True NA
176 19016 Pparg False True NA
177 19045 NA False True NA
178 19360 NA False True NA
179 19384 NA False True NA
180 19387 NA False True NA
181 19655 NA False True NA
182 19942 NA False True NA
183 19944 NA False True NA
184 19946 NA False True NA
185 19951 NA False True NA
186 20005 NA False True NA
187 20024 NA False True NA
188 20054 NA False True NA
189 20068 NA False True NA
190 20088 NA False True NA
191 20133 NA False True NA
192 20191 NA False True NA
193 20382 NA False True NA
194 20383 Srsf3 False True NA
195 20586 NA False True NA
196 20614 Snap25 False True NA
197 20641 NA False True NA
198 20740 NA False True NA
199 20823 NA False True NA
200 20832 NA False True NA
201 21672 NA False True NA
202 21894 NA False True NA
203 21917 NA False True NA
204 21937 NA False True NA
205 21991 NA False True NA
206 22070 NA False True NA
207 22129 Ttc3 False True NA
208 22273 NA False True NA
209 22334 NA False True NA
210 22335 NA False True NA
211 22608 NA False True NA
212 22791 NA False True NA
213 22849 CPEB3 False True NA
214 22888 NA False True NA
215 23024 NA False True NA
216 23558 NA False True NA
217 23983 NA False True NA
218 24061 NA False True NA
219 24158 NA False True Beta oxidation of octanoyl-CoA to hexanoyl-CoA
220 24159 NA True False ChREBP activates metabolic gene expression;Neutrophil degranulation;Fatty acyl-CoA biosynthesis
221 24161 NA True False NA
222 24170 NA True False NA
223 24171 NA True False Miscellaneous transport and binding events
224 24183 NA True False NA
225 24185 Akt1 False True PIP3 activates AKT signaling;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;mTOR signalling;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the nucleus;Negative regulation of the PI3K/AKT network;eNOS activation;Integrin alphaIIb beta3 signaling;Deactivation of the beta-catenin transactivating complex;CD28 dependent PI3K/Akt signaling;CTLA4 inhibitory signaling;G beta:gamma signalling through PI3Kgamma;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;VEGFR2 mediated vascular permeability;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
226 24186 NA True False Platelet degranulation ;Recycling of bile acids and salts;Scavenging of heme from plasma;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Transport of organic anions;Post-translational protein phosphorylation;HDL remodeling
227 24189 NA True False Platelet degranulation ;Neutrophil degranulation;Gluconeogenesis
228 24191 NA True False Neutrophil degranulation;Gluconeogenesis
229 24192 NA True False Pregnenolone biosynthesis
230 24205 Apc False True Apoptotic cleavage of cellular proteins;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;Deactivation of the beta-catenin transactivating complex;Ovarian tumor domain proteases
231 24211 Atp1a1 True True Ion homeostasis;Ion transport by P-type ATPases
232 24212 Atp1a2 True True Ion homeostasis;Ion transport by P-type ATPases
233 24213 Atp1a3 True True Ion homeostasis;Ion transport by P-type ATPases
234 24215 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases
235 24223 B2m False True ER-Phagosome pathway;Endosomal/Vacuolar pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 interactions;DAP12 signaling;Neutrophil degranulation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
236 24232 NA True False Alternative complement activation;Activation of C3 and C5;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (i) signalling events;Neutrophil degranulation;Post-translational protein phosphorylation;Regulation of Complement cascade
237 24233 NA False True NA
238 24242 Calm1 True True CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;Platelet degranulation ;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;eNOS activation;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;VEGFR2 mediated vascular permeability;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Glycogen breakdown (glycogenolysis);Protein methylation;Ion transport by P-type ATPases;Activation of RAC1 downstream of NMDARs;Long-term potentiation
239 24244 NA True False CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;Platelet degranulation ;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;eNOS activation;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;VEGFR2 mediated vascular permeability;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Glycogen breakdown (glycogenolysis);Protein methylation;Ion transport by P-type ATPases;Activation of RAC1 downstream of NMDARs;Long-term potentiation
240 24245 Camk2b True True HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Interferon gamma signaling;Ion transport by P-type ATPases
241 24248 NA False True Detoxification of Reactive Oxygen Species;Neutrophil degranulation;Peroxisomal protein import
242 24250 NA True False Cysteine formation from homocysteine
243 24264 NA True False Creatine metabolism
244 24265 NA False True Creatine metabolism
245 24316 Drd1 False True Dopamine receptors;G alpha (s) signalling events
246 24329 Egfr False True NA
247 24333 NA True False Gluconeogenesis
248 24334 NA True False Gluconeogenesis
249 24367 NA True False Platelet degranulation ;Common Pathway of Fibrin Clot Formation;Integrin cell surface interactions;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAP2K and MAPK activation;Post-translational protein phosphorylation
250 24368 NA True False Citric acid cycle (TCA cycle)
251 24377 NA True False TP53 Regulates Metabolic Genes;Pentose phosphate pathway
252 24380 NA True False GABA synthesis;GABA synthesis, release, reuptake and degradation
253 24383 Gapdh True True NA
254 24387 NA True False NA
255 24392 Gja1 True True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;Gap junction degradation;c-src mediated regulation of Cx43 function and closure of gap junctions;Formation of annular gap junctions;Transport of connexins along the secretory pathway
256 24398 Gls True True NA
257 24399 NA True False Transcriptional activation of mitochondrial biogenesis;Amino acid synthesis and interconversion (transamination)
258 24400 Gnb1 True True Activation of G protein gated Potassium channels;G-protein activation;Activation of the phototransduction cascade;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Olfactory Signaling Pathway;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
259 24401 NA True False Amino acid synthesis and interconversion (transamination)
260 24408 Grin1 True True EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade;Synaptic adhesion-like molecules
261 24409 Grin2a True True NA
262 24410 Grin2b True True EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade;Synaptic adhesion-like molecules
263 24414 Grm1 False True G alpha (q) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);Neurexins and neuroligins
264 24416 Grm3 True True G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)
265 24417 Grm4 False True NA
266 24418 Grm5 True True NA
267 24421 NA True False NA
268 24423 Gstm1 True True NA
269 24424 NA False True Glutathione conjugation
270 24426 NA True False Glutathione conjugation;Detoxification of Reactive Oxygen Species;Neutrophil degranulation
271 24437 NA True False NA
272 24439 NA True False Pyruvate metabolism
273 24440 NA True False NA
274 24465 NA True False Purine salvage
275 24468 Hspa8 True True NA
276 24472 NA True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation
277 24479 NA True False NADPH regeneration;Neutrophil degranulation;Peroxisomal protein import
278 24511 Itgb1 False True Elastic fibre formation;Fibronectin matrix formation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;Basigin interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Laminin interactions;Syndecan interactions;ECM proteoglycans;Signal transduction by L1;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;MET activates PTK2 signaling;MET interacts with TNS proteins
279 24513 NA True False Branched-chain amino acid catabolism
280 24525 Kras True True Activation of RAS in B cells;SHC1 events in ERBB4 signaling;Signaling by SCF-KIT;p38MAPK events;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;Downstream signal transduction;GRB2 events in ERBB2 signaling;Tie2 Signaling;EGFR Transactivation by Gastrin;DAP12 signaling;FCERI mediated MAPK activation;NCAM signaling for neurite out-growth;VEGFR2 mediated cell proliferation;CD209 (DC-SIGN) signaling;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Regulation of RAS by GAPs;RAF activation;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative regulation of MAPK pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAS signaling;RUNX3 regulates p14-ARF
281 24533 NA True False Pyruvate metabolism
282 24534 NA True False Pyruvate metabolism
283 24547 NA True False NA
284 24551 NA True False Gluconeogenesis
285 24585 NA False True Striated Muscle Contraction
286 24586 Ncam1 True True NA
287 24588 NA True False NA
288 24592 Nf1 True True NA
289 24596 Ngfr False True Axonal growth inhibition (RHOA activation);Regulated proteolysis of p75NTR;NFG and proNGF binds to p75NTR;NADE modulates death signalling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Axonal growth stimulation
290 24598 Nos1 False True ROS, RNS production in phagocytes;Nitric oxide stimulates guanylate cyclase;Ion homeostasis
291 24642 NA True False Neutrophil degranulation;Gluconeogenesis
292 24644 NA True False Gluconeogenesis
293 24648 NA True False Platelet degranulation ;COPII-mediated vesicle transport;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Neutrophil degranulation;Post-translational protein phosphorylation
294 24653 NA False True phospho-PLA2 pathway;Acyl chain remodelling of PC;Acyl chain remodeling of CL;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC;Synthesis of PA;Arachidonic acid metabolism;ADP signalling through P2Y purinoceptor 1;Platelet sensitization by LDL;COPI-independent Golgi-to-ER retrograde traffic
295 24654 Plcb1 True True NA
296 24666 Ppm1a True True NA
297 24668 NA True False DARPP-32 events
298 24672 Ppp2ca True True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;CTLA4 inhibitory signaling;RHO GTPases Activate Formins;RAF activation;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
299 24674 Ppp3ca True True Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation
300 24675 Ppp3cb True True NA
301 24679 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;Hedgehog 'off' state;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2;Factors involved in megakaryocyte development and platelet production
302 24680 Prkca False True Calmodulin induced events;Disinhibition of SNARE formation;SHC1 events in ERBB2 signaling;Signaling by SCF-KIT;Regulation of KIT signaling;EGFR Transactivation by Gastrin;Syndecan interactions;Acetylcholine regulates insulin secretion;Depolymerisation of the Nuclear Lamina;HuR (ELAVL1) binds and stabilizes mRNA;WNT5A-dependent internalization of FZD4;VEGFR2 mediated cell proliferation;Response to elevated platelet cytosolic Ca2+;RET signaling;ROBO receptors bind AKAP5
303 24681 Prkcg True True Calmodulin induced events;Disinhibition of SNARE formation;WNT5A-dependent internalization of FZD4;Response to elevated platelet cytosolic Ca2+
304 24686 Prnp True True NA
305 24688 NA False True NA
306 24691 NA False True Collagen degradation;Activation of Matrix Metalloproteinases;Cobalamin (Cbl, vitamin B12) transport and metabolism;Neutrophil degranulation;Antimicrobial peptides
307 24703 Raf1 False True Stimuli-sensing channels;Rap1 signalling;GP1b-IX-V activation signalling;CD209 (DC-SIGN) signaling;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway
308 24716 Ret True True RAF/MAP kinase cascade;RET signaling
309 24766 Scn2a True True NA
310 24767 Scnn1b False True Stimuli-sensing channels
311 24768 Scnn1g False True NA
312 24773 Sftpa1 False True Signal regulatory protein family interactions;Surfactant metabolism;Regulation of TLR by endogenous ligand
313 24778 Slc2a1 True True Cellular hexose transport;Vitamin C (ascorbate) metabolism;Regulation of insulin secretion;Lactose synthesis
314 24786 Sod1 True True Platelet degranulation ;Detoxification of Reactive Oxygen Species
315 24787 NA True False Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species
316 24799 NA True False NA
317 24803 Vamp2 True True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Clathrin derived vesicle budding;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Other interleukin signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;GABA synthesis, release, reuptake and degradation
318 24804 Syp True True NA
319 24818 NA True False Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
320 24825 NA True False Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation;Iron uptake and transport;Transferrin endocytosis and recycling
321 24826 Tg False True NA
322 24828 NA True False Metalloprotease DUBs
323 24832 NA True False Post-translational modification: synthesis of GPI-anchored proteins
324 24838 NA False True Striated Muscle Contraction
325 24849 NA True False Glycolysis
326 24851 NA True False NA
327 24854 NA True False Platelet degranulation ;Terminal pathway of complement;Antimicrobial peptides;Regulation of Complement cascade
328 24855 Tsc2 False True Macroautophagy;Inhibition of TSC complex formation by PKB;AKT phosphorylates targets in the cytosol;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;TBC/RABGAPs
329 24875 NA False True NA
330 24887 Bax False True Release of apoptotic factors from the mitochondria;Activation, translocation and oligomerization of BAX;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
331 24888 Bcl2l1 False True NA
332 24896 NA True False NA
333 24898 Slc6a3 False True Dopamine clearance from the synaptic cleft;Na+/Cl- dependent neurotransmitter transporters
334 24917 NA True False NA
335 24923 Stx1b True True LGI-ADAM interactions
336 24936 NA True False Platelet degranulation ;Sperm:Oocyte Membrane Binding
337 24943 NA True False NA
338 24949 NA True False Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle
339 24954 Insr False True PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;Insulin receptor signalling cascade;Signaling by Insulin receptor;Insulin receptor recycling
340 24957 NA True False Astrocytic Glutamate-Glutamine Uptake And Metabolism;Amino acid synthesis and interconversion (transamination)
341 24963 NA False True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation
342 25009 NA True False NA
343 25012 Snap25 True True NA
344 25014 NA True False Branched-chain amino acid catabolism
345 25017 NA True False NA
346 25023 Prkcb True True NA
347 25027 NA False True Basigin interactions;Proton-coupled monocarboxylate transport;Pyruvate metabolism
348 25035 NA True False Vitamin C (ascorbate) metabolism;Phase I - Functionalization of compounds;Neutrophil degranulation
349 25037 NA True False NA
350 25050 NA False True CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
351 25051 NA False True NA
352 25054 Ntrk2 True True Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through FRS2 and FRS3;NTRK2 activates RAC1
353 25058 NA True False NA
354 25059 Hk2 False True Glycolysis
355 25062 NA True False NA
356 25085 Th False True Catecholamine biosynthesis
357 25097 Pld2 False True NA
358 25101 NA False True Highly sodium permeable acetylcholine nicotinic receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly calcium permeable nicotinic acetylcholine receptors
359 25104 NA True False Biotin transport and metabolism;Gluconeogenesis
360 25122 Scnn1a False True Stimuli-sensing channels
361 25124 NA False True Interleukin-6 signaling;ISG15 antiviral mechanism;Signaling by SCF-KIT;Downstream signal transduction;Interleukin-4 and Interleukin-13 signaling;Interferon gamma signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-27 signaling;Interleukin-21 signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling
362 25130 Stx2 False True NA
363 25135 NA False True Major pathway of rRNA processing in the nucleolus and cytosol
364 25152 Map1a True True NA
365 25176 NA True False Regulation of insulin secretion
366 25177 NA False True NA
367 25181 NA False True A tetrasaccharide linker sequence is required for GAG synthesis;Chondroitin sulfate biosynthesis;Dermatan sulfate biosynthesis;CS/DS degradation;ECM proteoglycans
368 25183 NA True False Rho GTPase cycle;RAB GEFs exchange GTP for GDP on RABs
369 25218 NA False True Retrograde transport at the Trans-Golgi-Network
370 25230 NA True False Miscellaneous transport and binding events
371 25244 NA True False NA
372 25246 NA True False Degradation of the extracellular matrix;Basigin interactions;Integrin cell surface interactions;Proton-coupled monocarboxylate transport;Pyruvate metabolism
373 25248 Cnr1 True True Class A/1 (Rhodopsin-like receptors);G alpha (i) signalling events
374 25252 Dlg1 True True NA
375 25262 Itpr1 True True Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;cGMP effects;Ion homeostasis;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
376 25270 NA True False ABC transporters in lipid homeostasis
377 25272 NA True False Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors
378 25274 NA True False Degradation of cysteine and homocysteine
379 25275 Cnp True True NA
380 25282 NA True False NA
381 25287 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
382 25288 NA False True alpha-linolenic acid (ALA) metabolism;Synthesis of very long-chain fatty acyl-CoAs
383 25291 NA True False NA
384 25293 NA True False Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins
385 25303 Abcc2 False True ABC-family proteins mediated transport
386 25307 NA True False Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation
387 25309 NA True False NA
388 25316 Ms4a2 False True NA
389 25319 NA True False NA
390 25344 NA True False NA
391 25349 NA True False Phase 0 - rapid depolarisation
392 25353 Spp1 False True Degradation of the extracellular matrix;Signaling by PDGF;Integrin cell surface interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
393 25356 NA True False NA
394 25363 NA False True NA
395 25368 NA True False Purine salvage
396 25379 NA True False NA
397 25380 NA False True G alpha (q) signalling events;G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands
398 25388 Arrb2 False True G alpha (s) signalling events;Thrombin signalling through proteinase activated receptors (PARs);WNT5A-dependent internalization of FZD4;Activation of SMO;MAP2K and MAPK activation;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
399 25390 NA False True Basigin interactions;Ion homeostasis;Ion transport by P-type ATPases
400 25393 NA True False Degradation of the extracellular matrix;A tetrasaccharide linker sequence is required for GAG synthesis;Chondroitin sulfate biosynthesis;Dermatan sulfate biosynthesis;CS/DS degradation;ECM proteoglycans
401 25398 Cacna1a False True NA
402 25399 NA False True NA
403 25400 Camk2a True True NA
404 25413 NA False True NA
405 25414 Bcar1 False True NA
406 25415 NA True False CRMPs in Sema3A signaling
407 25416 Dpysl2 True True CRMPs in Sema3A signaling;Recycling pathway of L1
408 25417 NA True False CRMPs in Sema3A signaling
409 25418 NA True False CRMPs in Sema3A signaling
410 25420 NA True False HSF1-dependent transactivation
411 25434 NA True False NA
412 25438 NA False True Gluconeogenesis
413 25448 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase
414 25450 NA True False GABA A receptor activation
415 25456 Glrb False True Neurotransmitter receptors and postsynaptic signal transmission
416 25459 NA True False NA
417 25466 NA False True PIP3 activates AKT signaling;Receptor-type tyrosine-protein phosphatases;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-36 pathway;Interleukin-33 signaling;Interleukin-1 signaling
418 25467 Irs1 False True NA
419 25468 Kcna2 True True Voltage gated Potassium channels
420 25470 Kcna5 False True Voltage gated Potassium channels
421 25473 NA True False Laminin interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MET activates PTK2 signaling;Post-translational protein phosphorylation
422 25485 NA True False NA
423 25489 Nedd4 True True ISG15 antiviral mechanism;Downregulation of ERBB4 signaling;Regulation of PTEN localization;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation
424 25498 NA False True NA
425 25506 P4hb True True Collagen biosynthesis and modifying enzymes;Detoxification of Reactive Oxygen Species;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Hedgehog ligand biogenesis;Post-translational protein phosphorylation;Chylomicron assembly;Interleukin-12 signaling
426 25513 Pik3r1 False True PI3K Cascade;IRS-mediated signalling;GPVI-mediated activation cascade;PI3K events in ERBB4 signaling;PIP3 activates AKT signaling;Interleukin-7 signaling;Signaling by SCF-KIT;Synthesis of PIPs at the plasma membrane;GAB1 signalosome;Downstream signal transduction;PI3K events in ERBB2 signaling;PI3K/AKT activation;Downstream TCR signaling;Role of phospholipids in phagocytosis;Tie2 Signaling;DAP12 signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Costimulation by the CD28 family;CD28 dependent PI3K/Akt signaling;G alpha (q) signalling events;GP1b-IX-V activation signalling;VEGFA-VEGFR2 Pathway;Interleukin-3, Interleukin-5 and GM-CSF signaling;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates PI3K/AKT signaling;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Interleukin receptor SHC signaling;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
427 25518 NA True False NA
428 25522 Prkcz False True TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);VEGFR2 mediated cell proliferation
429 25528 NA True False Cell surface interactions at the vascular wall;DAP12 interactions;Signal regulatory protein family interactions;Neutrophil degranulation
430 25529 NA True False NA
431 25531 NA True False Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs;GABA synthesis, release, reuptake and degradation
432 25537 NA True False EPHB-mediated forward signaling;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases Activate ROCKs
433 25538 NA False True L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
434 25551 NA True False Cellular hexose transport;Vitamin C (ascorbate) metabolism;Neutrophil degranulation
435 25558 Stxbp1 True True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation
436 25562 Tceb3 False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation
437 25567 Tnr True True NA
438 25573 Ube2i False True SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Formation of Incision Complex in GG-NER;Negative regulation of activity of TFAP2 (AP-2) family transcription factors
439 25576 Ywhah True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
440 25577 NA True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors
441 25578 Ywhaz True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Deactivation of the beta-catenin transactivating complex;Rap1 signalling;GP1b-IX-V activation signalling;KSRP (KHSRP) binds and destabilizes mRNA;Interleukin-3, Interleukin-5 and GM-CSF signaling;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;NOTCH4 Activation and Transmission of Signal to the Nucleus;Regulation of localization of FOXO transcription factors
442 25581 Psmc2 True True NA
443 25594 NA True False Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate PAKs
444 25595 NA True False NA
445 25596 NA False True NA
446 25603 NA False True Acetylcholine regulates insulin secretion
447 25604 NA True False NA
448 25613 Ptprz1 True True Other interleukin signaling
449 25617 Hspa5 True True Regulation of HSF1-mediated heat shock response;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
450 25622 Ptpn11 True True Interleukin-6 signaling;PI3K Cascade;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;GAB1 signalosome;Downstream signal transduction;Tie2 Signaling;Costimulation by the CD28 family;CTLA4 inhibitory signaling;PD-1 signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;FRS-mediated FGFR2 signaling;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;Interleukin-20 family signaling;MET activates PTPN11;Regulation of RUNX1 Expression and Activity;Interferon alpha/beta signaling;Regulation of IFNA signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
451 25630 NA True False Neutrophil degranulation;Glycolysis
452 25632 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma
453 25636 Prkaca False True PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;Regulation of insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;VEGFA-VEGFR2 Pathway;CREB1 phosphorylation through the activation of Adenylate Cyclase;Interleukin-3, Interleukin-5 and GM-CSF signaling;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'off' state;Anchoring of the basal body to the plasma membrane;CD209 (DC-SIGN) signaling;MAPK6/MAPK4 signaling;AURKA Activation by TPX2;HDL assembly;Factors involved in megakaryocyte development and platelet production
454 25639 NA True False TGF-beta receptor signaling activates SMADs
455 25650 NA True False Basigin interactions;Ion homeostasis;Ion transport by P-type ATPases
456 25663 NA False True Interleukin-1 signaling
457 25669 NA True False NA
458 25671 NA False True NA
459 25673 NA True False Platelet degranulation
460 25686 NA True False PLC beta mediated events;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
461 25697 NA False True Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
462 25716 NA True False Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;GABA synthesis, release, reuptake and degradation
463 25721 NA True False Glyoxylate metabolism and glycine degradation;Amino acid synthesis and interconversion (transamination)
464 25722 Scn4a False True Phase 0 - rapid depolarisation
465 25725 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;Hedgehog 'off' state;Factors involved in megakaryocyte development and platelet production
466 25728 NA True False Scavenging by Class A Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Chylomicron clearance;HDL remodeling;Retinoid metabolism and transport
467 25736 Kcnb1 False True Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
468 25738 Plcg1 False True NA
469 25739 NA True False NA
470 25740 NA True False PLC beta mediated events;G-protein activation;G alpha (z) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
471 25741 NA True False Neutrophil degranulation;Glycolysis
472 25742 S100b True True TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Advanced glycosylation endproduct receptor signaling;TRAF6 mediated NF-kB activation
473 25750 NA True False Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
474 25751 Dnm2 True True Gap junction degradation;Formation of annular gap junctions;NOSTRIN mediated eNOS trafficking;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Clathrin-mediated endocytosis
475 25897 NA False True NA
476 25932 NA False True NA
477 26192 NA False True NA
478 26193 NA True False Respiratory electron transport;Complex I biogenesis
479 26195 NA True False NA
480 26198 NA True False NA
481 26201 NA True False Respiratory electron transport;Complex I biogenesis
482 26202 NA True False Respiratory electron transport;Complex I biogenesis
483 26204 NA True False NA
484 26291 NA False True NA
485 26295 Ogt True True HATs acetylate histones;UCH proteinases
486 26409 NA False True NA
487 26519 NA False True NA
488 26574 AATF False True NA
489 26759 NA True False Mitochondrial Fatty Acid Beta-Oxidation
490 26900 NA False True NA
491 26955 NA True False NA
492 26956 NA True False NA
493 26962 NA True False NA
494 26989 Cadps True True NA
495 27041 NA False True NA
496 27139 NA True False NA
497 27367 NA False True NA
498 28298 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
499 29139 Dcn False True Degradation of the extracellular matrix;A tetrasaccharide linker sequence is required for GAG synthesis;Chondroitin sulfate biosynthesis;Dermatan sulfate biosynthesis;CS/DS degradation;ECM proteoglycans
500 29144 Canx True True MHC class II antigen presentation;Interleukin-35 Signalling;Calnexin/calreticulin cycle;Interleukin-27 signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
501 29149 NA True False NA
502 29150 NA True False NA
503 29154 Capn2 True True Degradation of the extracellular matrix
504 29158 NA False True Elastic fibre formation;Molecules associated with elastic fibres
505 29161 Cav3 False True Smooth Muscle Contraction
506 29167 NA True False NA
507 29177 NA True False NA
508 29179 NA True False NA
509 29205 NA True False Neutrophil degranulation
510 29209 NA False True NA
511 29213 NA False True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Kinesins
512 29214 Tubb5 True True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;AURKA Activation by TPX2
513 29219 Snca True True NA
514 29220 NA False True Signaling by PDGF
515 29221 NA False True Neutrophil degranulation;Urea cycle
516 29223 NA True False Interconversion of nucleotide di- and triphosphates
517 29224 NA True False NA
518 29236 NA True False NA
519 29254 NA True False Acyl chain remodeling of DAG and TAG;Arachidonate production from DAG
520 29258 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
521 29271 Cfl1 True True NA
522 29272 NA True False NA
523 29275 NA True False Striated Muscle Contraction
524 29276 NA True False NA
525 29278 NA True False NA
526 29282 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
527 29283 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
528 29284 NA True False NA
529 29286 NA True False NA
530 29287 NA True False NA
531 29288 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
532 29304 NA True False NA
533 29309 NA False True Ubiquinol biosynthesis
534 29318 NA True False NA
535 29331 NA True False ECM proteoglycans
536 29338 NA True False Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes
537 29340 Prkce True True NA
538 29366 NA False True Intrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Dissolution of Fibrin Clot
539 29374 NA True False Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
540 29376 Irs2 False True PI3K Cascade;IRS-mediated signalling;SOS-mediated signalling;PIP3 activates AKT signaling;Interleukin-7 signaling;PI3K/AKT activation;IRS-related events triggered by IGF1R;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates RAS
541 29382 Ctbp1 True True Deactivation of the beta-catenin transactivating complex;SUMOylation of transcription cofactors;Repression of WNT target genes
542 29383 NA True False NA
543 29384 NA True False NA
544 29409 NA True False Axonal growth inhibition (RHOA activation);Basigin interactions
545 29411 NA True False Fatty acyl-CoA biosynthesis
546 29423 Gap43 True True L1CAM interactions
547 29425 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
548 29428 NA True False NA
549 29431 Pak1 True True Generation of second messenger molecules;Regulation of actin dynamics for phagocytic cup formation;FCERI mediated MAPK activation;DSCAM interactions;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;Ephrin signaling;Sema3A PAK dependent Axon repulsion;Signal transduction by L1;Smooth Muscle Contraction;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling;G beta:gamma signalling through CDC42
550 29432 Pak2 False True Generation of second messenger molecules;FCERI mediated MAPK activation;CD28 dependent Vav1 pathway;Ephrin signaling;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling
551 29433 Pak3 True True Generation of second messenger molecules;CD28 dependent Vav1 pathway;Ephrin signaling;Sema3A PAK dependent Axon repulsion;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling
552 29437 NA False True Striated Muscle Contraction
553 29441 NA True False NA
554 29443 NA True False Methylation;Sulfur amino acid metabolism
555 29445 NA True False NA
556 29448 NA True False MHC class II antigen presentation;Neutrophil degranulation;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
557 29456 Map1b True True NA
558 29457 NA True False NA
559 29468 NA True False NA
560 29473 Aoc3 False True Phase I - Functionalization of compounds
561 29474 NA True False NA
562 29477 Mapt False True Caspase-mediated cleavage of cytoskeletal proteins
563 29482 NA True False NA
564 29483 NA True False Astrocytic Glutamate-Glutamine Uptake And Metabolism;Glutamate Neurotransmitter Release Cycle;Transport of inorganic cations/anions and amino acids/oligopeptides
565 29489 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2
566 29491 Itsn1 True True NRAGE signals death through JNK;Rho GTPase cycle;EPHB-mediated forward signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
567 29495 Dlg4 True True Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Activation of Ca-permeable Kainate Receptor;RHO GTPases activate CIT;RAF/MAP kinase cascade;LGI-ADAM interactions;Neurexins and neuroligins;Synaptic adhesion-like molecules
568 29507 NA True False NA
569 29511 NA True False NA
570 29521 NA True False NA
571 29525 NA True False NA
572 29527 Ptgs2 False True Nicotinamide salvaging;Synthesis of 15-eicosatetraenoic acid derivatives;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Biosynthesis of EPA-derived SPMs;Biosynthesis of DPAn-3 SPMs;Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
573 29539 Aldh2 True True Ethanol oxidation
574 29542 Pebp1 True True MAP2K and MAPK activation;Negative regulation of MAPK pathway
575 29545 Uchl1 True True UCH proteinases
576 29546 Homer1 True True Neurexins and neuroligins
577 29547 Homer2 False True Neurexins and neuroligins
578 29548 Homer3 True True Neurexins and neuroligins
579 29555 NA False True G alpha (s) signalling events;Glucagon-type ligand receptors
580 29557 NA False True NA
581 29561 NA True False NA
582 29562 Prps1 True True 5-Phosphoribose 1-diphosphate biosynthesis
583 29564 Dync1i1 True True NA
584 29565 NA True False Peptide chain elongation;Synthesis of diphthamide-EEF2;Neutrophil degranulation;Protein methylation
585 29578 NA True False NA
586 29592 NA True False Branched-chain amino acid catabolism
587 29598 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases
588 29599 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases
589 29600 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases
590 29627 Gria2 True True NA
591 29628 NA True False Activation of AMPA receptors;Trafficking of AMPA receptors;Trafficking of GluR2-containing AMPA receptors;Synaptic adhesion-like molecules
592 29630 Psme1 False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
593 29635 NA False True NA
594 29637 NA True False Cholesterol biosynthesis
595 29647 Cask True True NA
596 29648 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Mitotic Telophase/Cytokinesis
597 29660 NA False True NA
598 29662 NA True False Rho GTPase cycle;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs
599 29663 NA True False MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis
600 29666 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
601 29668 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
602 29669 Psma2 True True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation
603 29670 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
604 29671 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
605 29673 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
606 29675 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
607 29677 Psmc3 True True NA
608 29681 NA True False Intrinsic Pathway of Fibrin Clot Formation
609 29682 Kcnq3 False True NA
610 29691 NA False True Cam-PDE 1 activation;cGMP effects;G alpha (s) signalling events
611 29693 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases
612 29699 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;Hedgehog 'off' state;Factors involved in megakaryocyte development and platelet production
613 29704 NA True False NA
614 29705 NA True False GABA A receptor activation
615 29715 Slc8a1 True True Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis
616 29738 Kcnab2 True True Voltage gated Potassium channels;Neutrophil degranulation
617 29748 NA True False Activation of BAD and translocation to mitochondria ;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation
618 29752 NA False True NA
619 29753 NA True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Signaling by Hippo;NADE modulates death signalling;Regulation of PLK1 Activity at G2/M Transition;Regulation of HSF1-mediated heat shock response;HSF1 activation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;RAB GEFs exchange GTP for GDP on RABs
620 29757 NA True False ROS, RNS production in phagocytes;Neutrophil degranulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
621 50522 Ubc False True NA
622 50557 Pten False True Synthesis of PIPs at the plasma membrane;Synthesis of IP3 and IP4 in the cytosol;Negative regulation of the PI3K/AKT network;Downstream TCR signaling;Ub-specific processing proteases;Ovarian tumor domain proteases;Regulation of PTEN localization;Regulation of PTEN stability and activity
623 50567 NA True False Basigin interactions;Amino acid transport across the plasma membrane;Tryptophan catabolism
624 50592 Gria1 True True NA
625 50646 Ptk2b True True Signal regulatory protein family interactions;VEGFA-VEGFR2 Pathway;Interleukin-2 signaling
626 50655 NA True False NA
627 50663 NA True False CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;Platelet degranulation ;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;eNOS activation;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;VEGFR2 mediated vascular permeability;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Glycogen breakdown (glycogenolysis);Protein methylation;Ion transport by P-type ATPases;Activation of RAC1 downstream of NMDARs;Long-term potentiation
628 50664 Gnao1 True True PLC beta mediated events;G-protein activation;Ca2+ pathway;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
629 50671 NA True False ChREBP activates metabolic gene expression;Vitamin B5 (pantothenate) metabolism;Fatty acyl-CoA biosynthesis
630 50686 NA True False NA
631 50687 L1cam True True Basigin interactions;L1CAM interactions;Recycling pathway of L1;Interaction between L1 and Ankyrins;Signal transduction by L1
632 50689 Mapk3 True True MAPK3 (ERK1) activation;RAF-independent MAPK1/3 activation;ISG15 antiviral mechanism;Spry regulation of FGF signaling;Golgi Cisternae Pericentriolar Stack Reorganization;Frs2-mediated activation;ERK/MAPK targets;ERKs are inactivated;Regulation of actin dynamics for phagocytic cup formation;Senescence-Associated Secretory Phenotype (SASP);NCAM signaling for neurite out-growth;Signal transduction by L1;Activation of the AP-1 family of transcription factors;Thrombin signalling through proteinase activated receptors (PARs);Negative regulation of FGFR1 signaling;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RNA Polymerase I Promoter Opening;Signal attenuation;Gastrin-CREB signalling pathway via PKC and MAPK;Growth hormone receptor signaling
633 50693 NA True False Platelet degranulation
634 50719 NA True False Basigin interactions;Amino acid transport across the plasma membrane;Tryptophan catabolism
635 50818 NA False True NA
636 50861 NA False True NA
637 50864 NA True False NA
638 51776 NA False True NA
639 51788 NA False True NA
640 53319 NA False True NA
641 53356 NA False True NA
642 53381 NA False True NA
643 54226 App True True Platelet degranulation ;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;G alpha (i) signalling events;Lysosome Vesicle Biogenesis;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Advanced glycosylation endproduct receptor signaling;Post-translational protein phosphorylation;TRAF6 mediated NF-kB activation
644 54231 NA True False Erythrocytes take up carbon dioxide and release oxygen;Reversible hydration of carbon dioxide
645 54241 NA True False NA
646 54245 Crk True True ARMS-mediated activation;Downstream signal transduction;Regulation of actin dynamics for phagocytic cup formation;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;MET receptor recycling;Regulation of signaling by CBL
647 54248 NA True False NA
648 54257 Grik2 False True Activation of Na-permeable kainate receptors;Activation of Ca-permeable Kainate Receptor
649 54293 NA False True G alpha (q) signalling events;G alpha (i) signalling events
650 54296 NA True False NA
651 54308 NA True False NA
652 54318 NA False True L13a-mediated translational silencing of Ceruloplasmin expression;PERK regulates gene expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP
653 54319 NA True False Netrin-1 signaling;Recycling pathway of L1
654 54321 Cnn3 False True NA
655 54322 NA True False NA
656 54323 Arc False True NA
657 54348 NA True False NA
658 54709 NA False True NA
659 55172 NA False True NA
660 55651 NA False True NA
661 55803 NA False True NA
662 55810 NA False True NA
663 56003 NA True False NA
664 56010 NA True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Regulation of localization of FOXO transcription factors
665 56011 Ywhab True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;mTOR signalling;mTORC1-mediated signalling;Signaling by Hippo;Rap1 signalling;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors
666 56012 NA False True NA
667 56029 Srcin1 True True NA
668 56040 NA False True NA
669 56042 NA True False COPII-mediated vesicle transport;COPI-mediated anterograde transport
670 56064 NA True False NA
671 56084 Hgs True True NA
672 56086 NA False True NA
673 56227 Espn False True NA
674 56403 NA False True NA
675 56456 NA False True NA
676 56611 NA False True Neutrophil degranulation;Dissolution of Fibrin Clot
677 56646 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
678 56718 Mtor True True PIP3 activates AKT signaling;Macroautophagy;mTOR signalling;mTORC1-mediated signalling;HSF1-dependent transactivation;Energy dependent regulation of mTOR by LKB1-AMPK;CD28 dependent PI3K/Akt signaling;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription
679 56768 NA True False NA
680 56781 NA False True Striated Muscle Contraction
681 56783 Eif5 True True Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
682 56813 NA False True Class B/2 (Secretin family receptors);G alpha (s) signalling events
683 56816 Park2 False True NA
684 56941 NA False True NA
685 57048 NA False True NA
686 57118 NA False True NA
687 57120 GOPC False True NA
688 58814 NA True False Striated Muscle Contraction
689 58815 NA True False NA
690 58819 NA False True NA
691 58823 NA True False NA
692 58835 NA True False Serine biosynthesis
693 58857 NA True False Sphingolipid de novo biosynthesis;Neutrophil degranulation
694 58917 NA True False Scavenging of heme from plasma
695 58920 NA True False NA
696 58940 NA True False NA
697 58945 NA False True NA
698 58948 NA True False Unblocking of NMDA receptors, glutamate binding and activation;Activation of Ca-permeable Kainate Receptor;RAF/MAP kinase cascade;Neurexins and neuroligins;Synaptic adhesion-like molecules
699 58953 NA True False Cytosolic sulfonation of small molecules
700 58959 NA False True Class B/2 (Secretin family receptors);G alpha (s) signalling events
701 58974 Gabarap False True Macroautophagy;TBC/RABGAPs
702 59069 NA False True NA
703 59114 Slc9a3r1 True True NA
704 59312 Shank3 False True NA
705 59317 NA True False Trafficking of AMPA receptors;Neurexins and neuroligins
706 59322 NA True False MAP2K and MAPK activation
707 59323 Erbb4 False True NA
708 60324 NA True False NA
709 60331 Atxn3 False True Josephin domain DUBs;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
710 60335 NA False True Formation of the cornified envelope
711 60341 Camkk1 True True CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Activation of RAC1 downstream of NMDARs
712 60355 NA True False NA
713 60377 NA False True Dopamine Neurotransmitter Release Cycle;RHO GTPases Activate Rhotekin and Rhophilins
714 60383 Rbck1 False True Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Antigen processing: Ubiquitination & Proteasome degradation
715 60384 NA False True NA
716 60391 Nrxn1 True True NA
717 60416 NA True False NA
718 60431 NA True False Sphingolipid de novo biosynthesis
719 60432 NA False True G alpha (s) signalling events;Glucagon-type ligand receptors
720 60443 NA False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
721 60445 Tsc1 False True Macroautophagy;Inhibition of TSC complex formation by PKB;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;TBC/RABGAPs
722 60465 NA True False Clathrin-mediated endocytosis
723 60466 NA True False NA
724 60562 Stx6 True True Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network
725 60581 NA True False NA
726 60666 NA True False Synthesis of PA
727 60668 Amph True True NA
728 63836 NA True False Platelet degranulation
729 63837 NA True False NA
730 63839 NA False True NA
731 63864 NA True False Branched-chain amino acid catabolism
732 63868 Hspd1 True True NA
733 63879 Xiap False True SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;SMAC, XIAP-regulated apoptotic response;Deactivation of the beta-catenin transactivating complex;RIPK1-mediated regulated necrosis;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Regulation of necroptotic cell death;Regulation of PTEN localization;Regulation of PTEN stability and activity
734 63938 NA True False Branched-chain amino acid catabolism
735 64001 NA True False Vitamin C (ascorbate) metabolism
736 64040 NA True False Carnitine synthesis
737 64053 NA True False NA
738 64057 NA True False NA
739 64156 NA True False NA
740 64157 NA True False eNOS activation
741 64158 Tuba1a True True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Kinesins
742 64159 Sptan1 True True Caspase-mediated cleavage of cytoskeletal proteins;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;Neutrophil degranulation;COPI-mediated anterograde transport
743 64160 NA True False NA
744 64161 NA True False NA
745 64169 NA True False NA
746 64185 NA True False Neutrophil degranulation
747 64189 NA True False Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic
748 64192 NA True False Phenylalanine and tyrosine catabolism
749 64200 NA True False FGFR2 alternative splicing;mRNA Splicing - Major Pathway
750 64201 NA True False NA
751 64202 Calr True True ER-Phagosome pathway;Scavenging by Class A Receptors;Calnexin/calreticulin cycle;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
752 64204 NA False True Assembly of collagen fibrils and other multimeric structures;Caspase-mediated cleavage of cytoskeletal proteins;Type I hemidesmosome assembly
753 64205 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
754 64298 NA True False NA
755 64300 NA True False NA
756 64302 NA True False NA
757 64303 NA False True Signaling by ROBO receptors;PCP/CE pathway;RHO GTPases Activate Formins
758 64304 NA False True Beta oxidation of butanoyl-CoA to acetyl-CoA
759 64306 NA True False NA
760 64307 NA True False NA
761 64310 NA True False Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;MHC class II antigen presentation;Clathrin derived vesicle budding;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Intra-Golgi traffic
762 64313 NA True False Amino acid synthesis and interconversion (transamination)
763 64351 NA True False COPII-mediated vesicle transport;COPI-mediated anterograde transport;Intra-Golgi traffic
764 64352 NA True False Glutathione conjugation
765 64356 Nrgn True True Long-term potentiation
766 64363 NA False True RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway
767 64367 NA True False Collagen biosynthesis and modifying enzymes
768 64371 NA True False NA
769 64373 NA True False GPVI-mediated activation cascade;Rho GTPase cycle;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases Activate Formins
770 64392 NA True False NA
771 64465 Cdc42 True True GPVI-mediated activation cascade;EGFR downregulation;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;G beta:gamma signalling through CDC42;Factors involved in megakaryocyte development and platelet production
772 64473 NA True False Cytosolic sulfonation of small molecules
773 64507 NA False True NA
774 64515 Cdc20 False True Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;Inactivation of APC/C via direct inhibition of the APC/C complex;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;APC/C:Cdc20 mediated degradation of Cyclin B;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of Emi1;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Ub-specific processing proteases;Mitotic Prometaphase;Antigen processing: Ubiquitination & Proteasome degradation
775 64517 NA True False Antigen processing: Ubiquitination & Proteasome degradation
776 64524 NA True False NA
777 64525 NA True False Formation of RNA Pol II elongation complex ;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
778 64526 NA True False Peroxisomal protein import
779 64527 NA False True Neutrophil degranulation
780 64533 NA True False Vitamins B6 activation to pyridoxal phosphate
781 64547 Bcl2l11 False True Activation of BIM and translocation to mitochondria ;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;NRAGE signals death through JNK
782 64551 NA True False MAPK6/MAPK4 signaling
783 64553 NA True False NA
784 64627 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
785 64633 NA True False NA
786 64635 NA True False NA
787 64640 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
788 64646 NA True False NA
789 64647 NA True False NA
790 64664 NA True False NA
791 64665 NA True False Synaptic adhesion-like molecules
792 64667 Sgta True True NA
793 64672 NA False True Ion homeostasis;Ion transport by P-type ATPases
794 64681 NA False True Neutrophil degranulation
795 64701 NA True False NA
796 64829 NA True False NA
797 64845 Gphn True True NA
798 64862 Map1lc3b False True NA
799 65028 NA True False NA
800 65033 NA True False NA
801 65040 Dlgap1 False True Neurexins and neuroligins
802 65042 NA True False NA
803 65046 NA True False Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
804 65114 NA False True NA
805 65136 NA True False NA
806 65137 Ruvbl1 True True UCH proteinases;Ub-specific processing proteases;DNA Damage Recognition in GG-NER;Deposition of new CENPA-containing nucleosomes at the centromere
807 65138 NA False True UCH proteinases;Ub-specific processing proteases
808 65151 NA True False Threonine catabolism
809 65152 NA True False NA
810 65158 NA True False NA
811 65171 NA True False NA
812 65178 Snap91 True True NA
813 65179 NA True False Negative regulation of MAPK pathway;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;ESR-mediated signaling
814 65183 NA True False Sphingolipid de novo biosynthesis;Alpha-oxidation of phytanate
815 65208 NA True False CRMPs in Sema3A signaling
816 65218 Agap2 True True NA
817 65262 NA True False NA
818 65997 NA False True NA
819 66028 NA True False NA
820 66030 NA True False NA
821 66031 NA True False NA
822 66108 NA False True NA
823 66475 NA False True NA
824 66480 NA False True NA
825 66511 NA False True NA
826 66592 NA False True NA
827 66870 NA False True NA
828 67059 NA False True NA
829 67097 NA False True NA
830 67115 NA False True NA
831 67186 NA False True NA
832 67332 NA False True NA
833 67427 NA False True NA
834 67628 NA False True NA
835 67738 NA False True NA
836 67891 NA False True NA
837 67958 NA False True NA
838 67979 NA False True NA
839 68349 NA False True NA
840 71679 NA False True NA
841 72900 NA False True NA
842 73333 NA False True NA
843 73830 NA False True NA
844 75273 NA False True NA
845 75705 NA False True NA
846 76808 NA False True NA
847 78957 Shank1 True True Neurexins and neuroligins
848 78959 NA True False Glutathione conjugation;Formation of xylulose-5-phosphate
849 79011 NA True False NA
850 79039 NA False True NA
851 79117 NA True False COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
852 79130 NA True False Neutrophil degranulation;GABA synthesis, release, reuptake and degradation
853 79131 NA False True Triglyceride catabolism
854 79212 NA True False Na+/Cl- dependent neurotransmitter transporters;Reuptake of GABA
855 79213 NA True False Na+/Cl- dependent neurotransmitter transporters;Creatine metabolism;Reuptake of GABA
856 79239 NA True False Heme degradation;Neutrophil degranulation;Iron uptake and transport
857 79244 NA False True Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import
858 79249 NA True False Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs
859 79250 NA True False Citric acid cycle (TCA cycle)
860 79251 NA True False Amino acid synthesis and interconversion (transamination)
861 79256 NA True False AUF1 (hnRNP D0) binds and destabilizes mRNA;mRNA Splicing - Major Pathway
862 79257 Axin1 False True NA
863 79433 NA True False NA
864 79434 Rab11b True True TBC/RABGAPs;RAB geranylgeranylation
865 79449 NA False True NA
866 79451 NA False True NA
867 79559 NA True False NA
868 80773 NA True False Phase I - Functionalization of compounds
869 80841 NA True False Triglyceride catabolism
870 80846 NA True False mRNA Splicing - Major Pathway
871 80849 NA True False NA
872 81022 Stxbp5 True True NA
873 81504 Grb2 True True PI3K Cascade;SOS-mediated signalling;SHC1 events in ERBB4 signaling;PIP3 activates AKT signaling;Spry regulation of FGF signaling;Signaling by SCF-KIT;Regulation of KIT signaling;Signalling to RAS;GRB2 events in EGFR signaling;GAB1 signalosome;SHC1 events in EGFR signaling;EGFR downregulation;Downstream signal transduction;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Regulation of actin dynamics for phagocytic cup formation;Tie2 Signaling;EGFR Transactivation by Gastrin;DAP12 signaling;SHC-related events triggered by IGF1R;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;GRB2:SOS provides linkage to MAPK signaling for Integrins ;NCAM signaling for neurite out-growth;Costimulation by the CD28 family;CD28 dependent Vav1 pathway;Signal regulatory protein family interactions;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;Negative regulation of MET activity;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Insulin receptor signalling cascade;MET activates RAS signaling;MET activates PI3K/AKT signaling;RET signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;MET activates PTPN11;MET activates RAP1 and RAC1;MET receptor recycling;Interleukin-15 signaling;Erythropoietin activates RAS;Activated NTRK2 signals through FRS2 and FRS3;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
874 81515 Lyn False True GPVI-mediated activation cascade;Signaling by SCF-KIT;Regulation of KIT signaling;Cell surface interactions at the vascular wall;FCGR activation;Fc epsilon receptor (FCERI) signaling;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;CD28 co-stimulation;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;CD209 (DC-SIGN) signaling;CD22 mediated BCR regulation;Cyclin D associated events in G1;Platelet Adhesion to exposed collagen;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates RAS;Regulation of signaling by CBL;Growth hormone receptor signaling
875 81529 NA False True NA
876 81530 NA True False NA
877 81531 NA True False Signaling by ROBO receptors;RHO GTPases Activate Formins
878 81632 NA True False Degradation of GABA
879 81634 NA True False Platelet degranulation ;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
880 81637 Ap2a2 False True Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Neutrophil degranulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
881 81643 NA True False Purine ribonucleoside monophosphate biosynthesis
882 81650 Csnk2b True True WNT mediated activation of DVL;Signal transduction by L1;Neutrophil degranulation;Regulation of TP53 Activity through Phosphorylation;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity
883 81653 Dbn1 True True NA
884 81654 NA True False Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism
885 81661 NA True False NA
886 81662 NA True False NA
887 81664 NA True False PLC beta mediated events;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
888 81666 NA True False NA
889 81667 NA True False Activation of G protein gated Potassium channels;G-protein activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
890 81672 Grm7 False True NA
891 81677 NA True False Synthesis of IP3 and IP4 in the cytosol
892 81682 NA False True Keratan sulfate biosynthesis;Keratan sulfate degradation;Integrin cell surface interactions
893 81683 NA True False Cell surface interactions at the vascular wall;Neutrophil degranulation
894 81708 NA True False Branched-chain amino acid catabolism
895 81722 Ager False True TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Advanced glycosylation endproduct receptor signaling;TRAF6 mediated NF-kB activation
896 81728 NA True False Respiratory electron transport;Complex I biogenesis
897 81732 NA True False Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis
898 81743 NA True False cGMP effects;G alpha (s) signalling events
899 81753 NA False True NA
900 81754 NA True False Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
901 81757 Rala True True Translocation of SLC2A4 (GLUT4) to the plasma membrane
902 81761 NA True False NA
903 81763 NA True False NA
904 81764 NA True False NA
905 81765 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
906 81766 NA True False NA
907 81767 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
908 81768 NA False True NA
909 81772 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
910 81773 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
911 81774 NA False True NA
912 81779 NA False True NA
913 81783 NA False True NA
914 81800 NA True False NA
915 81802 Stx3 False True Other interleukin signaling
916 81804 Stxbp2 False True NA
917 81807 Tceb2 True True Formation of RNA Pol II elongation complex ;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
918 81815 NA True False Antigen processing: Ubiquitination & Proteasome degradation
919 81818 NA True False NA
920 81822 Actb True True Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Adherens junctions interactions;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;B-WICH complex positively regulates rRNA expression;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;MAP2K and MAPK activation;UCH proteinases;DNA Damage Recognition in GG-NER;Clathrin-mediated endocytosis
921 81824 NA True False NA
922 81827 Psmc5 True True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
923 81829 NA True False Citric acid cycle (TCA cycle)
924 81869 NA True False Glutathione conjugation
925 81898 NA False True NA
926 81921 NA True False EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
927 81922 Sh3gl1 True True EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
928 83422 NA False True NA
929 83427 NA True False Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production
930 83471 NA True False NA
931 83501 NA True False NA
932 83506 Camkk2 False True NA
933 83510 NA True False L1CAM interactions
934 83523 NA True False NA
935 83527 NA True False Caspase-mediated cleavage of cytoskeletal proteins;Neurexins and neuroligins;Neutrophil degranulation
936 83529 Vdac1 True True Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases;Pyruvate metabolism
937 83531 NA True False Ub-specific processing proteases
938 83532 NA True False NA
939 83533 NA False True NA
940 83534 NA True False NA
941 83572 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2
942 83576 NA True False Golgi Associated Vesicle Biogenesis
943 83578 NA True False NA
944 83579 NA True False NA
945 83589 Apba1 False True NA
946 83610 Apba2 False True NA
947 83612 NA True False Transport of inorganic cations/anions and amino acids/oligopeptides;GABA synthesis, release, reuptake and degradation
948 83613 Nefl True True Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade
949 83615 NA True False NA
950 83616 NA True False NA
951 83688 NA True False Pentose phosphate pathway
952 83707 NA False True NA
953 83709 Git1 True True NA
954 83712 NA True False PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;PKMTs methylate histone lysines;HATs acetylate histones;RMTs methylate histone arginines;Deposition of new CENPA-containing nucleosomes at the centromere;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Neddylation;Transcriptional Regulation by E2F6
955 83718 Clic4 True True NA
956 83725 Wfs1 False True NA
957 83731 Kcnma1 True True Ca2+ activated K+ channels
958 83764 NA True False Synaptic adhesion-like molecules
959 83765 Rtn4 True True Axonal growth inhibition (RHOA activation)
960 83782 Nme2 True True Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation
961 83788 NA True False NA
962 83789 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;RMTs methylate histone arginines;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Protein methylation;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
963 83800 Clta True True Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
964 83806 NA True False NA
965 83807 NA False True NA
966 83809 Nsfl1c True True NA
967 83823 NA True False NA
968 83824 Cxxc4 False True NA
969 83825 NA True False NA
970 83839 NA True False NA
971 83841 Sdcbp False True Ephrin signaling;Neurofascin interactions;Neutrophil degranulation
972 84008 NA True False NA
973 84013 NA False True Androgen biosynthesis;Synthesis of very long-chain fatty acyl-CoAs
974 84014 NA False True NA
975 84016 NA False True NA
976 84027 Gsk3b False True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;CRMPs in Sema3A signaling;Disassembly of the destruction complex and recruitment of AXIN to the membrane;B-WICH complex positively regulates rRNA expression
977 84309 NA False True NA
978 84310 NA False True NA
979 84353 Ctnnb1 True True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;TCF dependent signaling in response to WNT;Formation of the beta-catenin:TCF transactivating complex;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Apoptotic cleavage of cell adhesion proteins;CDO in myogenesis;Deactivation of the beta-catenin transactivating complex;Ca2+ pathway;Adherens junctions interactions;VEGFR2 mediated vascular permeability;RHO GTPases activate IQGAPs;RUNX3 regulates WNT signaling
980 84356 NA False True NA
981 84379 NA True False Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
982 84431 NA True False Glycosphingolipid metabolism;Neutrophil degranulation
983 84469 Maged1 False True NA
984 84471 NA True False NA
985 84472 NA True False NA
986 84474 NA True False NA
987 84478 Ufd1l False True Translesion Synthesis by POLH;Ub-specific processing proteases
988 84479 NA False True NA
989 84484 NA True False Bicarbonate transporters
990 84496 NA False True NA
991 84509 NA True False NA
992 84550 NA True False Sodium/Calcium exchangers
993 84556 NA True False Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation
994 84591 Pick1 False True NA
995 84685 Ppp1r9a True True NA
996 84686 NA True False NA
997 85238 Synj1 True True Synthesis of PIPs at the plasma membrane;Synthesis of IP2, IP, and Ins in the cytosol;Synthesis of IP3 and IP4 in the cytosol;Clathrin-mediated endocytosis
998 85252 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Deactivation of the beta-catenin transactivating complex;HuR (ELAVL1) binds and stabilizes mRNA;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;Mitotic Prometaphase;Cyclin A/B1/B2 associated events during G2/M transition
999 85254 NA True False Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Choline catabolism
1000 85309 NA True False NA
1001 85327 Lin7a True True NA
1002 85333 NA True False NA
1003 85492 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1004 89789 NA False True NA
1005 89791 NA True False NA
1006 89841 NA True False Synthesis of PE
1007 89953 NA False True NA
1008 90933 NA False True NA
1009 93646 NA True False COPII-mediated vesicle transport;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1010 94167 Prdx6 True True Detoxification of Reactive Oxygen Species;Neutrophil degranulation
1011 94173 NA True False Citric acid cycle (TCA cycle)
1012 94193 NA True False Regulation of TNFR1 signaling;RAB GEFs exchange GTP for GDP on RABs
1013 94194 NA True False NA
1014 94197 NA True False Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
1015 94266 NA False True NA
1016 97165 NA False True NA
1017 98221 NA False True NA
1018 98238 NA False True NA
1019 101706 NA False True NA
1020 107686 NA False True NA
1021 107932 NA False True NA
1022 108017 NA False True NA
1023 108071 NA False True NA
1024 108989 NA False True NA
1025 110611 NA False True NA
1026 110954 NA False True NA
1027 110957 NA False True NA
1028 112295 Lmb1 False True NA
1029 113893 NA True False NA
1030 113894 Sqstm1 False True NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Pink/Parkin Mediated Mitophagy;Interleukin-1 signaling
1031 113898 NA True False NA
1032 113965 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
1033 113970 Magi2 False True NA
1034 114005 NA False True Glycogen synthesis
1035 114017 NA False True Mitochondrial translation elongation
1036 114023 NA False True Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
1037 114096 NA True False NA
1038 114101 NA True False NA
1039 114114 Dnm1l True True Apoptotic execution phase
1040 114122 NA True False NA
1041 114202 NA True False NA
1042 114486 Braf False True NA
1043 114513 NA True False NA
1044 114514 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
1045 114515 NA True False NA
1046 114520 NA True False NA
1047 114562 NA True False NA
1048 114591 NA True False NA
1049 114597 NA True False NA
1050 114612 NA True False Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing
1051 114641 NA False True NA
1052 114766 NA True False Processing of SMDT1
1053 115769 NA False True Signaling by Hippo;Apoptotic cleavage of cell adhesion proteins
1054 116463 NA True False Estrogen biosynthesis;Retinoid metabolism and transport
1055 116470 Stx1a True True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Other interleukin signaling;LGI-ADAM interactions;GABA synthesis, release, reuptake and degradation
1056 116482 NA True False Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the Golgi membrane
1057 116483 NA True False NA
1058 116484 NA True False NA
1059 116493 NA True False NA
1060 116506 NA False True G alpha (s) signalling events;Calcitonin-like ligand receptors
1061 116508 Nrxn3 True True NA
1062 116509 NA True False Na+/Cl- dependent neurotransmitter transporters
1063 116549 Csnk2a1 True True WNT mediated activation of DVL;Signal transduction by L1;Regulation of TP53 Activity through Phosphorylation;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity
1064 116561 NA True False Gap junction degradation;Formation of annular gap junctions;Lysosome Vesicle Biogenesis;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
1065 116563 NA True False Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
1066 116590 Mapk1 True True phospho-PLA2 pathway;RAF-independent MAPK1/3 activation;MAPK1 (ERK2) activation;Spry regulation of FGF signaling;Golgi Cisternae Pericentriolar Stack Reorganization;Frs2-mediated activation;ERK/MAPK targets;ERKs are inactivated;Regulation of actin dynamics for phagocytic cup formation;Senescence-Associated Secretory Phenotype (SASP);NCAM signaling for neurite out-growth;Recycling pathway of L1;Signal transduction by L1;Activation of the AP-1 family of transcription factors;Thrombin signalling through proteinase activated receptors (PARs);Negative regulation of FGFR1 signaling;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Neutrophil degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Gastrin-CREB signalling pathway via PKC and MAPK;Growth hormone receptor signaling
1067 116595 Nrxn2 True True Neurexins and neuroligins
1068 116597 NA True False NA
1069 116598 Pdia4 False True NA
1070 116599 NA True False Heme degradation
1071 116636 NA False True mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1072 116638 NA True False Glutamate Neurotransmitter Release Cycle;Organic anion transporters
1073 116643 Vcp True True Translesion Synthesis by POLH;HSF1 activation;ABC-family proteins mediated transport;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Hedgehog ligand biogenesis;Josephin domain DUBs;Ovarian tumor domain proteases;Neutrophil degranulation
1074 116644 Rtn1 True True NA
1075 116646 NA True False NA
1076 116653 NA True False NA
1077 116655 Hnrnpm True True FGFR2 alternative splicing;mRNA Splicing - Major Pathway
1078 116657 NA True False NA
1079 116673 NA False True A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG biosynthesis;HS-GAG degradation;Cell surface interactions at the vascular wall;Syndecan interactions;Retinoid metabolism and transport
1080 116685 Lmnb1 True True NA
1081 116690 Nfasc True True Neurofascin interactions;Neutrophil degranulation
1082 116698 NA True False Generic Transcription Pathway
1083 116723 NA True False NA
1084 116725 NA True False ISG15 antiviral mechanism;NOD1/2 Signaling Pathway;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;CLEC7A (Dectin-1) signaling;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;E3 ubiquitin ligases ubiquitinate target proteins;Interleukin-1 signaling;IRAK1 recruits IKK complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation
1085 116743 Sh3gl2 True True Retrograde neurotrophin signalling;EGFR downregulation;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
1086 117024 NA True False NA
1087 117028 Bin1 True True Clathrin-mediated endocytosis
1088 117030 NA True False NA
1089 117042 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1090 117044 NA True False Macroautophagy;mTOR signalling;mTORC1-mediated signalling;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;E3 ubiquitin ligases ubiquitinate target proteins;Regulation of PTEN gene transcription
1091 117053 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1092 117056 H3f3b True True PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production
1093 117099 NA False True Synthesis of Ketone Bodies
1094 117104 NA True False Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1095 117152 Cand1 True True Neutrophil degranulation;Neddylation;Iron uptake and transport
1096 117180 NA True False NA
1097 117243 NA True False Synthesis of very long-chain fatty acyl-CoAs
1098 117254 NA True False Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes
1099 117258 NA True False NA
1100 117262 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1101 117263 Psmc1 True True Autodegradation of Cdh1 by Cdh1:APC/C;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1102 117272 NA True False NA
1103 117273 Rhoa True True GPVI-mediated activation cascade;Axonal growth inhibition (RHOA activation);Rho GTPase cycle;PI3K/AKT activation;Axonal growth stimulation;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);G beta:gamma signalling through PI3Kgamma;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;PCP/CE pathway;G alpha (12/13) signalling events;Sema4D mediated inhibition of cell attachment and migration;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases Activate ROCKs;RHO GTPases Activate Formins;RHO GTPases Activate Rhotekin and Rhophilins;Ovarian tumor domain proteases;ERBB2 Regulates Cell Motility;Neutrophil degranulation;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;SLIT2:ROBO1 increases RHOA activity
1104 117277 Epn1 True True NA
1105 117282 NA True False mRNA Splicing - Major Pathway
1106 117284 Lrrc7 True True Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade;Neutrophil degranulation
1107 117287 Park7 True True SUMOylation of transcription cofactors
1108 117515 NA True False Anchoring of the basal body to the plasma membrane
1109 117520 NA True False NA
1110 117526 Tbp False True B-WICH complex positively regulates rRNA expression;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA polymerase II transcribes snRNA genes;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase I Transcription Termination;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;Estrogen-dependent gene expression
1111 117533 NA True False NA
1112 117542 Baiap2 True True Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs
1113 117543 NA True False mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
1114 117548 NA True False COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
1115 117550 NA True False MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
1116 117556 NA True False NA
1117 117557 NA True False Striated Muscle Contraction;Smooth Muscle Contraction
1118 117559 NA True False NA
1119 117596 NA True False ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
1120 122772 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1121 122799 NA True False NA
1122 124323 NA True False NA
1123 124461 NA True False Clathrin-mediated endocytosis
1124 126308 NA False True NA
1125 140290 NA False True NA
1126 140447 NA True False NA
1127 140448 NA True False Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis
1128 140547 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
1129 140593 Siah2 False True Netrin-1 signaling;Ub-specific processing proteases;Antigen processing: Ubiquitination & Proteasome degradation
1130 140597 NA False True NA
1131 140608 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation
1132 140639 Nploc4 False True NA
1133 140654 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1134 140655 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1135 140661 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1136 140662 NA False True NA
1137 140667 NA True False NA
1138 140670 Ap2b1 True True Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
1139 140671 NA False True Glycogen breakdown (glycogenolysis)
1140 140673 NA True False COPII-mediated vesicle transport;Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network
1141 140694 Dnm1 True True Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;Recycling pathway of L1;Clathrin-mediated endocytosis
1142 140722 Caskin1 True True NA
1143 140729 NA True False NA
1144 140734 NA True False Activation of BMF and translocation to mitochondria;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Macroautophagy;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Intraflagellar transport;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase
1145 140868 NA True False Triglyceride catabolism;Signaling by Retinoic Acid;Neutrophil degranulation
1146 140908 Cdk5 True True DARPP-32 events;CRMPs in Sema3A signaling;Regulation of TP53 Activity through Phosphorylation
1147 140922 NA True False NA
1148 140926 Daxx False True SUMOylation of transcription cofactors;Regulation of TP53 Degradation
1149 140927 NA True False NA
1150 140931 NA False True NA
1151 140941 Siah1 False True Netrin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation
1152 140945 NA True False Synaptic adhesion-like molecules
1153 146227 NA False True NA
1154 148252 NA False True NA
1155 154968 NA True False NA
1156 155151 NA True False NA
1157 156275 NA True False Aflatoxin activation and detoxification
1158 157074 NA True False Citric acid cycle (TCA cycle)
1159 161475 Psmd9 True True NA
1160 161477 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1161 170082 NA False True NA
1162 170465 NA True False NA
1163 170538 Prkcd False True NA
1164 170587 NA True False NA
1165 170667 NA True False ROS, RNS production in phagocytes;Neutrophil degranulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
1166 170670 NA True False Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA
1167 170673 NA True False NA
1168 170724 NA True False NA
1169 170751 NA True False NA
1170 170821 Atxn10 False True NA
1171 170840 Slc40a1 False True Metal ion SLC transporters;Iron uptake and transport
1172 170848 Kcnq2 False True NA
1173 170851 Map2k1 True True NA
1174 170915 Ep300 False True NA
1175 170916 NA True False NA
1176 170923 NA True False Neutrophil degranulation
1177 170930 NA False True NA
1178 171026 NA False True Trafficking of AMPA receptors;ROBO receptors bind AKAP5
1179 171039 NA True False NA
1180 171041 Klc1 True True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
1181 171050 Mob4 False True NA
1182 171058 NA True False RAB geranylgeranylation
1183 171082 NA False True Formation of ATP by chemiosmotic coupling;Cristae formation
1184 171086 Trak2 False True NA
1185 171093 NA True False NA
1186 171102 Cdc25a False True NA
1187 171103 Cdc25b False True NA
1188 171114 NA True False NA
1189 171116 NA True False Regulation of Apoptosis
1190 171119 NA True False NA
1191 171129 NA True False NA
1192 171137 NA True False KSRP (KHSRP) binds and destabilizes mRNA
1193 171140 NA True False HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Interferon gamma signaling;Ion transport by P-type ATPases
1194 171155 NA True False Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA
1195 171297 NA True False Neurexins and neuroligins
1196 171337 NA True False NA
1197 171350 Pabpc1 True True L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1198 171361 NA True False NA
1199 171373 NA True False NA
1200 171374 NA True False NA
1201 171375 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation
1202 171410 NA True False Synthesis of very long-chain fatty acyl-CoAs
1203 171444 NA True False NA
1204 171445 NA True False NA
1205 171451 NA True False Phase I - Functionalization of compounds
1206 171503 NA True False Activation of RAC1 downstream of NMDARs
1207 171574 NA True False MHC class II antigen presentation;Recycling pathway of L1;Clathrin-mediated endocytosis
1208 191575 NA True False Interconversion of nucleotide di- and triphosphates
1209 191576 NA True False Synthesis of very long-chain fatty acyl-CoAs
1210 191595 NA True False NA
1211 192117 NA False True Regulation of RAS by GAPs
1212 192152 Tgoln2 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Golgi Associated Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation
1213 192172 NA True False Degradation of cysteine and homocysteine
1214 192176 NA False True NA
1215 192179 NA True False NA
1216 192213 NA True False NA
1217 192226 NA False True NA
1218 192235 Hyou1 True True NA
1219 192241 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation
1220 192245 Hspb6 False True NA
1221 192249 NA True False Factors involved in megakaryocyte development and platelet production
1222 192253 NA True False NA
1223 192254 Grasp False True NA
1224 192255 NA False True NA
1225 192260 NA True False Synthesis of PI
1226 192268 NA True False Glutamate Neurotransmitter Release Cycle;TP53 Regulates Metabolic Genes;Amino acid synthesis and interconversion (transamination)
1227 192277 NA True False HSP90 chaperone cycle for steroid hormone receptors (SHR)
1228 192645 NA True False NA
1229 192647 NA False True NA
1230 201097 NA True False NA
1231 208691 NA False True NA
1232 217337 NA False True NA
1233 217737 NA False True NA
1234 218490 NA False True NA
1235 223696 NA False True NA
1236 228410 NA False True NA
1237 229279 NA False True NA
1238 230908 NA False True NA
1239 231887 NA False True NA
1240 234594 NA False True NA
1241 245709 NA True False Insulin processing;VxPx cargo-targeting to cilium
1242 245955 NA False True Platelet degranulation
1243 245965 NA True False NA
1244 245981 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1245 246118 Tubb3 True True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins
1246 246136 NA False True NA
1247 246302 NA True False NA
1248 246303 NA True False NA
1249 246307 NA True False Phenylalanine and tyrosine catabolism
1250 246310 Arfgap1 True True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Clathrin-mediated endocytosis
1251 246755 NA True False NA
1252 246757 Klhl17 False True NA
1253 246772 NA True False NA
1254 252881 NA True False Insulin processing;VxPx cargo-targeting to cilium
1255 252892 NA True False LGI-ADAM interactions
1256 252902 NA True False NA
1257 252919 NA True False Amino acid transport across the plasma membrane
1258 252921 NA False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
1259 252922 NA True False NA
1260 252934 NA True False NA
1261 259242 NA True False Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs
1262 259269 NA True False NA
1263 259274 NA True False Inactivation, recovery and regulation of the phototransduction cascade;Activation, myristolyation of BID and translocation to mitochondria
1264 260321 NA True False HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;ESR-mediated signaling;Estrogen-dependent gene expression
1265 261736 NA True False DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation
1266 261737 NA True False NA
1267 266759 Hspa4 True True NA
1268 266777 NA True False NA
1269 266975 NA True False NA
1270 267019 NA False True NA
1271 268373 NA False True NA
1272 269610 NA False True NA
1273 276770 NA False True NA
1274 281165 NA False True NA
1275 281296 NA False True NA
1276 282587 NA True False NA
1277 282827 Aip False True Aryl hydrocarbon receptor signalling
1278 282843 Sorbs3 False True Smooth Muscle Contraction
1279 284273 NA False True NA
1280 286761 NA True False Ovarian tumor domain proteases
1281 286770 DNAJC3 False True NA
1282 286906 NA True False Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
1283 286911 NA False True NA
1284 286928 NA False True NA
1285 286930 NA True False NA
1286 287061 NA True False NA
1287 287069 NA True False NA
1288 287115 NA True False NA
1289 287155 Stub1 False True Downregulation of TGF-beta receptor signaling;Downregulation of ERBB2 signaling;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation
1290 287156 NA True False Rho GTPase cycle
1291 287191 NA True False NA
1292 287276 NA True False COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Chylomicron assembly;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1293 287379 NA False True Carnitine synthesis
1294 287417 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1295 287444 NA True False Hypusine synthesis from eIF5A-lysine
1296 287446 NA False True NA
1297 287535 NA False True Retrograde transport at the Trans-Golgi-Network
1298 287633 NA True False NA
1299 287670 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1300 287702 NA False True Keratinization;Formation of the cornified envelope
1301 287716 Psme3 False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1302 287721 NA True False Neutrophil degranulation
1303 287876 NA False True Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Adherens junctions interactions;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;MAP2K and MAPK activation;Clathrin-mediated endocytosis
1304 287877 NA False True NA
1305 287927 NA True False Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;E3 ubiquitin ligases ubiquitinate target proteins;Antigen processing: Ubiquitination & Proteasome degradation
1306 287931 Ppm1f True True NA
1307 287984 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1308 287986 NA False True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;mTORC1-mediated signalling;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1309 288064 NA False True Activation of DNA fragmentation factor
1310 288174 NA True False Neutrophil degranulation
1311 288275 Hunk False True NA
1312 288444 NA True False Regulation of HSF1-mediated heat shock response
1313 288599 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1314 288620 NA False True Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
1315 288666 NA True False WNT ligand biogenesis and trafficking
1316 288707 NA True False Glycosphingolipid metabolism
1317 288778 NA True False Neutrophil degranulation
1318 288912 NA True False Methionine salvage pathway
1319 289019 NA True False NA
1320 289125 NA True False Mitochondrial Fatty Acid Beta-Oxidation
1321 289144 NA True False NA
1322 289218 NA True False Respiratory electron transport;Complex I biogenesis
1323 289222 NA True False NA
1324 289257 NA False True NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport
1325 289668 NA True False NA
1326 289820 NA True False Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis
1327 289950 NA True False Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism
1328 290029 NA True False Neutrophil degranulation;Purine catabolism
1329 290356 NA True False NA
1330 290364 Itm2b False True NA
1331 290401 NA True False Glutathione conjugation
1332 290408 NA True False The NLRP3 inflammasome
1333 290640 NA True False NA
1334 290641 NA True False NA
1335 290651 NA True False Synthesis of IP2, IP, and Ins in the cytosol
1336 290823 Erlin2 False True ABC-family proteins mediated transport
1337 290868 NA False True NA
1338 290880 NA False True NA
1339 291075 NA True False Beta-oxidation of very long chain fatty acids;Peroxisomal protein import
1340 291081 NA False True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins
1341 291103 NA True False NA
1342 291145 NA False True NA
1343 291152 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1344 291180 NA True False NA
1345 291394 NA True False Glutathione synthesis and recycling
1346 291434 NA True False NA
1347 291450 NA True False Choline catabolism;Lysine catabolism
1348 291671 Hspa9 False True Regulation of HSF1-mediated heat shock response
1349 291796 NA False True Ub-specific processing proteases
1350 291874 Nup93 False True Transport of Mature mRNA derived from an Intron-Containing Transcript;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of DNA replication proteins
1351 291877 NA False True Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs
1352 291926 NA False True NA
1353 291948 NA True False Neutrophil degranulation
1354 292023 NA True False NA
1355 292072 NA True False Neutrophil degranulation;Purine salvage
1356 292148 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1357 292156 NA True False NA
1358 292267 NA True False NA
1359 292597 NA True False Stimuli-sensing channels
1360 292732 Numbl True True NA
1361 292804 NA True False Neutrophil degranulation;Glycolysis
1362 292845 NA True False Respiratory electron transport;Protein methylation
1363 292925 Tsg101 True True Endosomal Sorting Complex Required For Transport (ESCRT)
1364 292994 NA False True NA
1365 293448 NA True False NA
1366 293481 NA True False NA
1367 293484 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1368 293508 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;Regulation of insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;VEGFA-VEGFR2 Pathway;CREB1 phosphorylation through the activation of Adenylate Cyclase;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'off' state;CD209 (DC-SIGN) signaling;MAPK6/MAPK4 signaling;HDL assembly;Factors involved in megakaryocyte development and platelet production
1369 293621 Hras True True Activation of RAS in B cells;SHC1 events in ERBB4 signaling;Signaling by SCF-KIT;p38MAPK events;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;Downstream signal transduction;GRB2 events in ERBB2 signaling;Tie2 Signaling;EGFR Transactivation by Gastrin;DAP12 signaling;FCERI mediated MAPK activation;NCAM signaling for neurite out-growth;EPHB-mediated forward signaling;VEGFR2 mediated cell proliferation;CD209 (DC-SIGN) signaling;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Regulation of RAS by GAPs;RAF activation;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative regulation of MAPK pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAS signaling
1370 293684 NA False True NA
1371 293692 NA True False Factors involved in megakaryocyte development and platelet production
1372 293705 Otub1 True True Ub-specific processing proteases;Ovarian tumor domain proteases
1373 293719 NA False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle
1374 293725 NA True False NA
1375 293860 NA False True Platelet degranulation ;GP1b-IX-V activation signalling;Cell-extracellular matrix interactions;RHO GTPases activate PAKs
1376 294010 NA True False MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2
1377 294239 NA True False eNOS activation
1378 294254 NA True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation
1379 294282 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1380 294292 NA True False Synthesis of pyrophosphates in the cytosol
1381 294320 NA True False Pyruvate metabolism
1382 294326 NA True False NA
1383 294362 NA True False NA
1384 294568 Wasf1 True True Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs
1385 294810 NA True False NA
1386 294864 NA True False NA
1387 294917 NA False True Oxidative Stress Induced Senescence
1388 294930 NA True False LDL clearance
1389 294972 NA False True NA
1390 295230 NA True False Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
1391 295277 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1392 295347 NA False True ARMS-mediated activation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;MAP2K and MAPK activation;Neutrophil degranulation;MET activates RAP1 and RAC1
1393 295619 NA True False NA
1394 295645 NA True False Bicarbonate transporters
1395 295690 NA False True NA
1396 295929 Mybpc3 False True Striated Muscle Contraction
1397 296131 NA True False NA
1398 296197 NA False True NA
1399 296267 NA True False NA
1400 296318 NA True False NA
1401 296344 NA False True NA
1402 296369 NA False True Striated Muscle Contraction
1403 296480 NA True False NA
1404 296488 NA True False Platelet degranulation
1405 296554 NA True False NA
1406 296570 NA False True NA
1407 296596 NA True False NA
1408 296709 NA True False NA
1409 296710 NA True False NA
1410 296758 NA True False NA
1411 297113 NA False True NA
1412 297428 NA False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
1413 297436 NA True False NA
1414 297518 NA False True Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis
1415 297566 NA True False NA
1416 297593 NA False True Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes
1417 297699 NA True False Downregulation of TGF-beta receptor signaling
1418 297994 Bag1 False True NA
1419 298012 Rad23b True True N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Josephin domain DUBs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER
1420 298079 NA True False NA
1421 298101 NA True False Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;MET activates PTK2 signaling;Collagen chain trimerization
1422 298203 NA True False Processing of SMDT1
1423 298410 NA True False Interconversion of nucleotide di- and triphosphates
1424 298584 NA True False MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Factors involved in megakaryocyte development and platelet production
1425 298596 NA True False Citric acid cycle (TCA cycle)
1426 298609 NA True False NA
1427 298771 NA True False NA
1428 298848 NA True False NA
1429 298917 NA True False NA
1430 298942 NA True False Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Glycine degradation;Pyruvate metabolism;Branched-chain amino acid catabolism;Lysine catabolism
1431 299027 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP
1432 299052 NA False True Platelet degranulation ;Neutrophil degranulation;Gluconeogenesis
1433 299194 NA True False NA
1434 299201 NA True False Glyoxylate metabolism and glycine degradation;Lysine catabolism
1435 299331 Hsp90aa1 True True Signaling by ERBB2;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression
1436 299809 NA True False Association of TriC/CCT with target proteins during biosynthesis;Neutrophil degranulation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
1437 299850 NA True False MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2
1438 299872 NA False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1439 299923 NA True False NA
1440 299971 NA True False ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
1441 300033 NA True False NA
1442 300079 NA True False NA
1443 300111 NA True False NA
1444 300218 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins
1445 300228 NA False True NA
1446 300247 NA False True Keratinization;Formation of the cornified envelope
1447 300250 NA False True Neutrophil degranulation;Keratinization;Formation of the cornified envelope
1448 300677 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation
1449 300724 NA False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
1450 300726 NA True False Respiratory electron transport
1451 300850 NA True False NA
1452 300968 NA True False Antigen processing: Ubiquitination & Proteasome degradation
1453 300981 NA True False Aflatoxin activation and detoxification
1454 301011 NA True False NA
1455 301252 NA True False Regulation of actin dynamics for phagocytic cup formation;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Sema3A PAK dependent Axon repulsion;Neutrophil degranulation;The NLRP3 inflammasome;The role of GTSE1 in G2/M progression after G2 checkpoint;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression
1456 301384 NA True False Branched-chain amino acid catabolism
1457 301442 Sumo1 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;Regulation of IFNG signaling;Negative regulation of activity of TFAP2 (AP-2) family transcription factors
1458 301458 NA True False Respiratory electron transport;Complex I biogenesis
1459 301555 Cul3 True True Degradation of DVL;Hedgehog 'on' state;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
1460 301618 NA True False NA
1461 302328 NA False True NA
1462 302395 NA False True NA
1463 302500 NA False True NA
1464 302796 NA True False NA
1465 302965 NA False True NA
1466 303222 NA True False Rho GTPase cycle
1467 303306 Srr True True Serine biosynthesis
1468 303634 NA True False NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs)
1469 303831 NA True False ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1470 304017 NA True False Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases
1471 304469 Rilpl1 False True NA
1472 304542 NA False True NA
1473 304656 NA False True NA
1474 304805 NA True False NA
1475 305021 NA True False Platelet degranulation
1476 305177 NA True False Methionine salvage pathway
1477 305178 NA False True NA
1478 305227 NA True False NA
1479 305288 NA False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
1480 305332 NA False True NA
1481 305457 NA True False NA
1482 305501 NA False True NA
1483 305614 Sptbn1 False True NA
1484 305679 NA True False Platelet degranulation ;Smooth Muscle Contraction;MAP2K and MAPK activation;Neutrophil degranulation
1485 306327 NA False True NA
1486 306332 Ap1m1 True True MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation
1487 306439 NA True False NA
1488 306626 NA False True NA
1489 306840 NA True False NA
1490 306934 NA True False NA
1491 307039 NA True False Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
1492 307309 Sncaip False True NA
1493 307351 NA False True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins
1494 307503 NA False True Eukaryotic Translation Termination;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1495 307511 Cdc25c False True Polo-like kinase mediated events;RHO GTPases activate PKNs;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;Cyclin A/B1/B2 associated events during G2/M transition;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
1496 307779 NA True False NA
1497 307821 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1498 308100 NA True False NA
1499 308113 NA False True NA
1500 308571 NA True False Receptor-type tyrosine-protein phosphatases
1501 308578 Ap2a1 False True Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
1502 308650 NA True False mRNA Splicing - Major Pathway
1503 308690 Ndn False True NA
1504 308709 NA False True NA
1505 308759 NA False True NA
1506 308901 Trim21 False True Regulation of innate immune responses to cytosolic DNA;Antigen processing: Ubiquitination & Proteasome degradation
1507 309168 Map3k11 False True RAF activation
1508 309557 NA False True Neurexins and neuroligins
1509 309774 Gopc False True NA
1510 309901 NA True False NA
1511 310635 NA True False NRAGE signals death through JNK;Rho GTPase cycle
1512 310820 NA True False NA
1513 311020 NA True False NA
1514 311078 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1515 311328 NA True False NA
1516 311422 NA True False Purine catabolism
1517 311621 NA True False NA
1518 311671 NA False True NA
1519 311786 Traf2 False True Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;Ub-specific processing proteases;Dimerization of procaspase-8;TNF signaling
1520 311848 NA True False NA
1521 311849 NA False True Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import
1522 311860 Abl1 False True Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;Role of ABL in ROBO-SLIT signaling;RHO GTPases Activate WASPs and WAVEs;HDR through Single Strand Annealing (SSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Cyclin D associated events in G1;RUNX1 regulates transcription of genes involved in differentiation of HSCs
1523 311913 NA False True RAB GEFs exchange GTP for GDP on RABs
1524 312083 NA False True NA
1525 312444 NA True False NA
1526 312694 Necap1 True True Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
1527 312965 Ubxn2b False True NA
1528 313047 NA True False NA
1529 313052 NA False True Neurexins and neuroligins
1530 313200 NA False True NA
1531 313234 NA True False TBC/RABGAPs
1532 313323 NA True False NA
1533 313413 NA True False NA
1534 313474 Eps15 False True NA
1535 313647 NA True False NA
1536 313658 NA True False NA
1537 313867 NA True False NA
1538 313934 NA False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
1539 314140 NA True False 5-Phosphoribose 1-diphosphate biosynthesis
1540 314432 NA True False Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation
1541 314442 NA True False NA
1542 314641 NA True False Synthesis of PIPs at the plasma membrane;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Clathrin-mediated endocytosis
1543 314721 NA True False NA
1544 314764 Eea1 False True NA
1545 314856 Mdm2 False True AKT phosphorylates targets in the cytosol;Oxidative Stress Induced Senescence;Oncogene Induced Senescence;SUMOylation of ubiquitinylation proteins;Trafficking of AMPA receptors;Ub-specific processing proteases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Stabilization of p53;Regulation of RUNX3 expression and activity
1546 314906 NA True False NA
1547 315159 Tob2 False True NA
1548 315265 NA True False NA
1549 315509 NA True False Cell surface interactions at the vascular wall;Integrin cell surface interactions
1550 315608 NA False True Antigen processing: Ubiquitination & Proteasome degradation
1551 315648 NA True False Inhibition of replication initiation of damaged DNA by RB1/E2F1;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;CTLA4 inhibitory signaling;RHO GTPases Activate Formins;RAF activation;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition
1552 315771 NA False True NA
1553 315840 NA False True NA
1554 315989 NA False True NA
1555 316123 NA False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;Estrogen-dependent gene expression
1556 316258 Cd2ap False True NA
1557 316531 NA True False Platelet degranulation ;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Kinesins
1558 316632 NA True False Respiratory electron transport;Complex I biogenesis
1559 316740 NA False True NA
1560 317259 NA True False NA
1561 319177 NA False True NA
1562 319184 NA False True NA
1563 319189 NA False True NA
1564 319190 NA False True NA
1565 319195 NA False True NA
1566 353227 Zbtb16 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
1567 360471 Usp7 True True NA
1568 360504 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma
1569 360543 NA False True NA
1570 360572 NA True False NA
1571 360593 NA True False NA
1572 360643 Cdc27 False True Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation
1573 360678 NA True False Axonal growth inhibition (RHOA activation);Rho GTPase cycle;Axonal growth stimulation
1574 360687 NA True False NA
1575 360820 Pxn False True GAB1 signalosome;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
1576 360853 NA False True UCH proteinases
1577 360854 NA False True Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis
1578 360882 NA True False Adherens junctions interactions;Nectin/Necl trans heterodimerization
1579 360887 NA False True NA
1580 360891 NA False True Signaling by ROBO receptors
1581 360915 NA True False DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation
1582 360921 NA True False NA
1583 360950 NA True False Platelet degranulation
1584 360975 NA True False Glyoxylate metabolism and glycine degradation;Lysine catabolism
1585 361118 NA True False NA
1586 361351 NA True False NA
1587 361370 NA False True Neutrophil degranulation
1588 361388 NA False True NA
1589 361422 NA True False Neutrophil degranulation
1590 361433 NA True False Glycerophospholipid biosynthesis
1591 361503 NA False True NA
1592 361527 NA True False Role of phospholipids in phagocytosis
1593 361532 NA True False NA
1594 361585 NA False True Antigen processing: Ubiquitination & Proteasome degradation
1595 361596 NA True False Transcriptional activation of mitochondrial biogenesis;Citric acid cycle (TCA cycle)
1596 361613 NA True False Cyclin A/B1/B2 associated events during G2/M transition
1597 361663 NA True False Purine ribonucleoside monophosphate biosynthesis
1598 361675 NA True False NA
1599 361677 Tollip True True Neutrophil degranulation;Interleukin-1 signaling
1600 361684 NA True False NA
1601 361791 NA False True NA
1602 361833 NA True False NA
1603 361884 NA False True Biotin transport and metabolism;Branched-chain amino acid catabolism
1604 361967 NA True False ESR-mediated signaling
1605 361970 Trim2 True True NA
1606 362013 NA True False Ion homeostasis
1607 362015 NA True False Purine salvage
1608 362036 Ank2 False True NA
1609 362152 NA True False mRNA Splicing - Major Pathway
1610 362182 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
1611 362245 Map1lc3a True True Macroautophagy;Pink/Parkin Mediated Mitophagy;Receptor Mediated Mitophagy
1612 362332 NA False True Cell-extracellular matrix interactions
1613 362361 NA True False NA
1614 362401 NA False True NA
1615 362440 NA True False Respiratory electron transport;Complex I biogenesis
1616 362479 NA False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation
1617 362587 Macf1 True True NA
1618 362595 NA False True NA
1619 362631 NA True False NA
1620 362634 NA False True Initial triggering of complement;Classical antibody-mediated complement activation;Regulation of Complement cascade
1621 362721 Tssc1 True True NA
1622 362738 NA False True NA
1623 362750 NA True False NA
1624 362809 NA True False Synthesis of Prostaglandins (PG) and Thromboxanes (TX);HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression
1625 362816 NA True False NA
1626 362817 Cdk2 False True G0 and Early G1;Activation of ATR in response to replication stress;Regulation of APC/C activators between G1/S and early anaphase;SCF(Skp2)-mediated degradation of p27/p21;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Processing of DNA double-strand break ends;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Degradation;G2 Phase;Orc1 removal from chromatin;Activation of the pre-replicative complex;CDK-mediated phosphorylation and removal of Cdc6;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates Cell Cycle
1627 362826 Atcay True True NA
1628 362849 March2 False True NA
1629 362855 NA True False NA
1630 362862 Hsp90b1 True True NA
1631 362950 NA True False FGFR2 alternative splicing
1632 362965 Rangap1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Mitotic Prometaphase
1633 362969 NA False True NA
1634 363024 NA True False Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Neutrophil degranulation
1635 363113 NA True False NA
1636 363150 NA False True NA
1637 363465 NA True False Digestion
1638 363644 NA True False NA
1639 363875 Rac1 True True GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;NRAGE signals death through JNK;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;DAP12 signaling;FCERI mediated MAPK activation;DSCAM interactions;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Sema3A PAK dependent Axon repulsion;PCP/CE pathway;Sema4D mediated inhibition of cell attachment and migration;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;Signal transduction by L1;VEGFR2 mediated vascular permeability;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate NADPH Oxidases;MAPK6/MAPK4 signaling;Neutrophil degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;NTRK2 activates RAC1;Factors involved in megakaryocyte development and platelet production
1640 363925 NA False True NA
1641 363972 NA True False NA
1642 364052 NA True False RAF-independent MAPK1/3 activation;RAF/MAP kinase cascade
1643 364208 NA True False NA
1644 364694 NA False True NA
1645 364716 NA False True NA
1646 364723 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1647 364838 NA True False Olfactory Signaling Pathway
1648 365216 NA True False NA
1649 365377 NA False True Smooth Muscle Contraction
1650 365388 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1651 365877 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1652 366189 NA False True NA
1653 366448 NA False True NA
1654 366568 NA True False NA
1655 367171 NA True False NA
1656 369016 NA True False NA
1657 369017 NA False True NA
1658 382522 NA False True NA
1659 397785 NA False True NA
1660 398985 NA False True NA
1661 403728 NA False True NA
1662 404093 NA False True NA
1663 406167 NA True False NA
1664 408248 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1665 432508 NA False True NA
1666 445442 NA False True NA
1667 450225 NA False True Keratinization;Formation of the cornified envelope
1668 493810 NA True False MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Advanced glycosylation endproduct receptor signaling;Factors involved in megakaryocyte development and platelet production
1669 494445 NA True False Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing
1670 497198 NA True False NA
1671 497794 NA True False NA
1672 497902 NA True False NA
1673 498174 NA False True NA
1674 498407 NA True False NA
1675 498433 NA False True UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1676 498736 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins
1677 498909 NA True False NA
1678 499417 Sumo3 False True SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription cofactors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of DNA replication proteins;SUMOylation of immune response proteins;Formation of Incision Complex in GG-NER
1679 499529 NA True False Respiratory electron transport;Complex I biogenesis
1680 499558 March11 False True NA
1681 499782 NA True False NA
1682 499913 NA True False Arachidonate production from DAG
1683 500105 Cntnap2 False True NA
1684 500282 NA True False NA
1685 500351 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1686 500377 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins
1687 500419 NA False True NA
1688 500450 NA False True Striated Muscle Contraction;Smooth Muscle Contraction
1689 500929 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins
1690 500985 Cbl False True Interleukin-6 signaling;Spry regulation of FGF signaling;Regulation of KIT signaling;EGFR downregulation;TGF-beta receptor signaling activates SMADs;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Negative regulation of MET activity;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Regulation of signaling by CBL
1691 501083 NA True False NA
1692 501621 NA False True Transport of Mature mRNA derived from an Intron-Containing Transcript
1693 501625 NA False True NA
1694 502125 NA True False NA
1695 502674 NA True False NA
1696 502776 NA True False NA
1697 502913 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1698 513971 NA False True NA
1699 613226 NA True False NA
1700 617095 NA False True NA
1701 618164 NA False True NA
1702 619561 NA False True Mitochondrial Fatty Acid Beta-Oxidation
1703 641434 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation
1704 678759 NA True False Respiratory electron transport;Complex I biogenesis
1705 679221 NA True False NA
1706 680102 NA False True NA
1707 680423 NA False True NA
1708 680522 NA False True NA
1709 681896 NA True False Organic anion transporters
1710 682507 Wasl False True Regulation of actin dynamics for phagocytic cup formation;NOSTRIN mediated eNOS trafficking;Nephrin family interactions;EPHB-mediated forward signaling;DCC mediated attractive signaling;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis
1711 683313 NA False True NA
1712 683788 NA True False NA
1713 684097 NA True False NA
1714 684988 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1715 685859 NA False True NA
1716 686098 Sorbs1 False True NA
1717 687008 NA True False NA
1718 687090 NA True False NA
1719 687506 NA False True NA
1720 688288 NA True False Cleavage of Growing Transcript in the Termination Region ;ISG15 antiviral mechanism;Transport of Mature mRNA derived from an Intron-Containing Transcript;Deadenylation of mRNA;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1721 688386 NA True False NA
1722 689064 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation
1723 689560 Ryr2 True True NA
1724 689852 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1725 690131 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1726 690163 NA True False Utilization of Ketone Bodies
1727 690244 NA False True NA
1728 690441 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation
1729 690660 NA True False NA
1730 690795 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1731 690987 NA False True Glycogen synthesis
1732 691149 NA True False NA
1733 691974 NA False True NA
1734 824261 NA False True NA
1735 852088 NA False True NA
1736 852107 NA False True NA
1737 853358 NA False True NA
1738 100134871 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation
1739 100145871 NA True False Ethanol oxidation
1740 100359951 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1741 100359982 NA True False NA
1742 100360117 NA True False NA
1743 100360180 NA True False NA
1744 100360501 NA True False NA
1745 100360508 NA True False NA
1746 100360679 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1747 100360846 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation
1748 100360977 NA True False NA
1749 100361558 NA True False PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production
1750 100361891 NA True False NA
1751 100361915 NA False True NA
1752 100362149 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1753 100362640 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1754 100362684 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1755 100362830 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1756 100363439 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1757 100363502 NA True False NA
1758 100364335 NA True False NA
1759 100365810 NA True False NA
1760 100909441 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins
1761 100909595 NA True False Cellular hexose transport;Vitamin C (ascorbate) metabolism;Neutrophil degranulation
1762 100909840 NA True False Signaling by ROBO receptors;RHO GTPases Activate Formins
1763 100911186 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
1764 100911372 NA True False NA
1765 100911402 NA True False NA
1766 100911417 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation
1767 100911625 NA True False Gluconeogenesis
1768 100912489 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1769 100912564 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1770 102555453 NA True False NA
1771 103689947 NA True False NA
1772 103689983 NA True False Purine salvage
1773 103689992 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1774 103689999 NA True False Platelet degranulation
1775 103690002 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression
1776 103690190 NA True False NA
1777 103692716 NA True False Signaling by ERBB2;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression
1778 103693564 NA True False NA
1779 103693780 NA True False Glyoxylate metabolism and glycine degradation;Lysine catabolism
1780 103694857 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation
1781 103694877 NA True False Cell surface interactions at the vascular wall;Neutrophil degranulation
1782 103694903 NA True False Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;CTLA4 inhibitory signaling;RHO GTPases Activate Formins;RAF activation;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1783 108348061 NA True False NA
1784 108348073 NA True False Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1785 108348108 NA True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation
1786 108348115 NA True False NA
1787 108348142 NA True False NA
1788 108348148 NA True False Glutathione conjugation
1789 108348161 NA True False NA
1790 108351137 NA True False NA
1791 NA NA True False NA