Mercurial > repos > proteore > proteore_build_protein_interaction_maps
diff test-data/Nodes_biogrid_from_Rattus_Hameza_dataset_geneID.tsv @ 2:99f6a94c1ade draft
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
| author | proteore |
|---|---|
| date | Fri, 28 Jun 2019 05:06:57 -0400 |
| parents | |
| children |
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/Nodes_biogrid_from_Rattus_Hameza_dataset_geneID.tsv Fri Jun 28 05:06:57 2019 -0400 @@ -0,0 +1,1791 @@ +Entrez gene ID Official Symbol Interactor Present in user input ids ID present in Biogrid Rat Pathway +25 ABL1 False True NA +81 ACTN4 False True NA +142 PARP1 False True NA +156 NA False True NA +160 AP2A1 False True NA +176 NA False True NA +207 AKT1 False True NA +273 AMPH False True NA +310 NA False True NA +366 NA False True NA +627 NA False True NA +640 NA False True NA +657 NA False True NA +658 NA False True NA +661 NA False True NA +673 NA False True NA +695 NA False True NA +815 CAMK2A False True NA +818 NA False True NA +857 NA False True NA +921 NA False True NA +1020 NA False True NA +1048 CEACAM5 False True NA +1147 CHUK False True NA +1326 NA False True NA +1457 NA False True NA +1742 DLG4 False True NA +1759 DNM1 False True NA +1956 NA False True NA +1969 NA False True NA +1978 NA False True NA +1983 NA False True NA +2054 STX2 False True NA +2060 EPS15 False True NA +2257 NA False True NA +2287 NA False True NA +2321 NA False True NA +2534 NA False True NA +2569 NA False True NA +2997 NA False True NA +3005 NA False True NA +3053 NA False True NA +3091 HIF1A False True NA +3337 DNAJB1 False True NA +3551 IKBKB False True NA +3897 L1CAM False True NA +4133 NA False True NA +4137 MAPT False True NA +4155 NA False True NA +4215 NA False True NA +4430 NA False True NA +4690 NA False True NA +4692 NA False True NA +4792 NA False True NA +4908 NTF3 False True NA +4915 NA False True NA +5156 NA False True NA +5340 NA False True NA +5414 NA False True NA +5467 NA False True NA +5481 NA False True NA +5518 NA False True NA +5580 NA False True NA +5604 NA False True NA +5638 NA False True NA +5829 NA False True NA +5998 NA False True NA +6300 NA False True NA +6330 NA False True NA +6449 NA False True NA +6477 SIAH1 False True NA +6622 SNCA False True NA +6721 NA False True NA +6769 NA False True NA +6804 STX1A False True NA +6809 STX3 False True NA +6810 STX4 False True NA +6857 NA False True NA +6885 NA False True NA +7006 NA False True NA +7041 TGFB1I1 False True NA +7157 TP53 False True NA +7265 NA False True NA +7266 NA False True NA +7528 NA False True NA +7704 ZBTB16 False True NA +7867 NA False True NA +7874 NA False True NA +7881 NA False True NA +8416 NA False True NA +8514 NA False True NA +8550 NA False True NA +8573 NA False True NA +8576 NA False True NA +8894 EIF2S2 False True NA +9014 NA False True NA +9040 NA False True NA +9379 NA False True NA +9454 HOMER3 False True NA +9495 AKAP5 False True NA +9616 NA False True NA +9962 NA False True NA +10000 NA False True NA +10013 HDAC6 False True NA +10018 BCL2L11 False True NA +10110 NA False True NA +10116 NA False True NA +10152 NA False True NA +10243 NA False True NA +10278 NA False True NA +10572 NA False True NA +10963 NA False True NA +11651 NA False True NA +11674 NA False True NA +11740 NA False True NA +11747 NA False True NA +11758 NA False True NA +11792 NA False True NA +11842 NA False True NA +11843 NA False True NA +11946 NA False True NA +11950 NA False True NA +12034 Phb2 False True NA +12043 NA False True NA +12346 NA False True NA +12349 NA False True NA +12416 NA False True NA +12461 NA False True NA +12468 NA False True NA +12540 NA False True NA +12631 NA False True NA +12995 NA False True NA +13211 NA False True NA +13628 Eef1a2 False True NA +13644 Efs False True NA +13665 NA False True NA +13682 NA False True NA +14182 Fgfr1 False True NA +14265 NA False True NA +14400 NA False True NA +14406 NA False True NA +14751 NA False True NA +14811 NA False True NA +14812 NA False True NA +14813 NA False True NA +15288 NA False True NA +15289 NA False True NA +15354 NA False True NA +15381 NA False True NA +15382 NA False True NA +15384 NA False True NA +15387 NA False True NA +15441 NA False True NA +15526 NA False True NA +15568 NA False True NA +16211 Kpnb1 False True NA +16647 Kpna2 False True NA +16649 Kpna4 False True NA +16906 NA False True NA +17089 NA False True NA +17192 NA False True NA +17220 NA False True NA +17448 NA False True NA +17920 NA False True NA +17938 NA False True NA +17999 Nedd4 False True NA +18102 NA False True NA +18148 NA False True NA +18150 NA False True NA +18477 NA False True NA +18521 NA False True NA +18648 NA False True NA +18674 NA False True NA +18795 NA False True NA +19016 Pparg False True NA +19045 NA False True NA +19360 NA False True NA +19384 NA False True NA +19387 NA False True NA +19655 NA False True NA +19942 NA False True NA +19944 NA False True NA +19946 NA False True NA +19951 NA False True NA +20005 NA False True NA +20024 NA False True NA +20054 NA False True NA +20068 NA False True NA +20088 NA False True NA +20133 NA False True NA +20191 NA False True NA +20382 NA False True NA +20383 Srsf3 False True NA +20586 NA False True NA +20614 Snap25 False True NA +20641 NA False True NA +20740 NA False True NA +20823 NA False True NA +20832 NA False True NA +21672 NA False True NA +21894 NA False True NA +21917 NA False True NA +21937 NA False True NA +21991 NA False True NA +22070 NA False True NA +22129 Ttc3 False True NA +22273 NA False True NA +22334 NA False True NA +22335 NA False True NA +22608 NA False True NA +22791 NA False True NA +22849 CPEB3 False True NA +22888 NA False True NA +23024 NA False True NA +23558 NA False True NA +23983 NA False True NA +24061 NA False True NA +24158 NA False True Beta oxidation of octanoyl-CoA to hexanoyl-CoA +24159 NA True False ChREBP activates metabolic gene expression;Neutrophil degranulation;Fatty acyl-CoA biosynthesis +24161 NA True False NA +24170 NA True False NA +24171 NA True False Miscellaneous transport and binding events +24183 NA True False NA +24185 Akt1 False True PIP3 activates AKT signaling;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;mTOR signalling;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the nucleus;Negative regulation of the PI3K/AKT network;eNOS activation;Integrin alphaIIb beta3 signaling;Deactivation of the beta-catenin transactivating complex;CD28 dependent PI3K/Akt signaling;CTLA4 inhibitory signaling;G beta:gamma signalling through PI3Kgamma;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;VEGFR2 mediated vascular permeability;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 +24186 NA True False Platelet degranulation ;Recycling of bile acids and salts;Scavenging of heme from plasma;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Transport of organic anions;Post-translational protein phosphorylation;HDL remodeling +24189 NA True False Platelet degranulation ;Neutrophil degranulation;Gluconeogenesis +24191 NA True False Neutrophil degranulation;Gluconeogenesis +24192 NA True False Pregnenolone biosynthesis +24205 Apc False True Apoptotic cleavage of cellular proteins;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;Deactivation of the beta-catenin transactivating complex;Ovarian tumor domain proteases +24211 Atp1a1 True True Ion homeostasis;Ion transport by P-type ATPases +24212 Atp1a2 True True Ion homeostasis;Ion transport by P-type ATPases +24213 Atp1a3 True True Ion homeostasis;Ion transport by P-type ATPases +24215 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases +24223 B2m False True ER-Phagosome pathway;Endosomal/Vacuolar pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 interactions;DAP12 signaling;Neutrophil degranulation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC +24232 NA True False Alternative complement activation;Activation of C3 and C5;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (i) signalling events;Neutrophil degranulation;Post-translational protein phosphorylation;Regulation of Complement cascade +24233 NA False True NA +24242 Calm1 True True CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;Platelet degranulation ;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;eNOS activation;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;VEGFR2 mediated vascular permeability;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Glycogen breakdown (glycogenolysis);Protein methylation;Ion transport by P-type ATPases;Activation of RAC1 downstream of NMDARs;Long-term potentiation +24244 NA True False CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;Platelet degranulation ;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;eNOS activation;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;VEGFR2 mediated vascular permeability;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Glycogen breakdown (glycogenolysis);Protein methylation;Ion transport by P-type ATPases;Activation of RAC1 downstream of NMDARs;Long-term potentiation +24245 Camk2b True True HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Interferon gamma signaling;Ion transport by P-type ATPases +24248 NA False True Detoxification of Reactive Oxygen Species;Neutrophil degranulation;Peroxisomal protein import +24250 NA True False Cysteine formation from homocysteine +24264 NA True False Creatine metabolism +24265 NA False True Creatine metabolism +24316 Drd1 False True Dopamine receptors;G alpha (s) signalling events +24329 Egfr False True NA +24333 NA True False Gluconeogenesis +24334 NA True False Gluconeogenesis +24367 NA True False Platelet degranulation ;Common Pathway of Fibrin Clot Formation;Integrin cell surface interactions;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAP2K and MAPK activation;Post-translational protein phosphorylation +24368 NA True False Citric acid cycle (TCA cycle) +24377 NA True False TP53 Regulates Metabolic Genes;Pentose phosphate pathway +24380 NA True False GABA synthesis;GABA synthesis, release, reuptake and degradation +24383 Gapdh True True NA +24387 NA True False NA +24392 Gja1 True True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;Gap junction degradation;c-src mediated regulation of Cx43 function and closure of gap junctions;Formation of annular gap junctions;Transport of connexins along the secretory pathway +24398 Gls True True NA +24399 NA True False Transcriptional activation of mitochondrial biogenesis;Amino acid synthesis and interconversion (transamination) +24400 Gnb1 True True Activation of G protein gated Potassium channels;G-protein activation;Activation of the phototransduction cascade;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Olfactory Signaling Pathway;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +24401 NA True False Amino acid synthesis and interconversion (transamination) +24408 Grin1 True True EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade;Synaptic adhesion-like molecules +24409 Grin2a True True NA +24410 Grin2b True True EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade;Synaptic adhesion-like molecules +24414 Grm1 False True G alpha (q) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);Neurexins and neuroligins +24416 Grm3 True True G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors) +24417 Grm4 False True NA +24418 Grm5 True True NA +24421 NA True False NA +24423 Gstm1 True True NA +24424 NA False True Glutathione conjugation +24426 NA True False Glutathione conjugation;Detoxification of Reactive Oxygen Species;Neutrophil degranulation +24437 NA True False NA +24439 NA True False Pyruvate metabolism +24440 NA True False NA +24465 NA True False Purine salvage +24468 Hspa8 True True NA +24472 NA True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation +24479 NA True False NADPH regeneration;Neutrophil degranulation;Peroxisomal protein import +24511 Itgb1 False True Elastic fibre formation;Fibronectin matrix formation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;Basigin interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Laminin interactions;Syndecan interactions;ECM proteoglycans;Signal transduction by L1;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;MET activates PTK2 signaling;MET interacts with TNS proteins +24513 NA True False Branched-chain amino acid catabolism +24525 Kras True True Activation of RAS in B cells;SHC1 events in ERBB4 signaling;Signaling by SCF-KIT;p38MAPK events;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;Downstream signal transduction;GRB2 events in ERBB2 signaling;Tie2 Signaling;EGFR Transactivation by Gastrin;DAP12 signaling;FCERI mediated MAPK activation;NCAM signaling for neurite out-growth;VEGFR2 mediated cell proliferation;CD209 (DC-SIGN) signaling;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Regulation of RAS by GAPs;RAF activation;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative regulation of MAPK pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAS signaling;RUNX3 regulates p14-ARF +24533 NA True False Pyruvate metabolism +24534 NA True False Pyruvate metabolism +24547 NA True False NA +24551 NA True False Gluconeogenesis +24585 NA False True Striated Muscle Contraction +24586 Ncam1 True True NA +24588 NA True False NA +24592 Nf1 True True NA +24596 Ngfr False True Axonal growth inhibition (RHOA activation);Regulated proteolysis of p75NTR;NFG and proNGF binds to p75NTR;NADE modulates death signalling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Axonal growth stimulation +24598 Nos1 False True ROS, RNS production in phagocytes;Nitric oxide stimulates guanylate cyclase;Ion homeostasis +24642 NA True False Neutrophil degranulation;Gluconeogenesis +24644 NA True False Gluconeogenesis +24648 NA True False Platelet degranulation ;COPII-mediated vesicle transport;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Neutrophil degranulation;Post-translational protein phosphorylation +24653 NA False True phospho-PLA2 pathway;Acyl chain remodelling of PC;Acyl chain remodeling of CL;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC;Synthesis of PA;Arachidonic acid metabolism;ADP signalling through P2Y purinoceptor 1;Platelet sensitization by LDL;COPI-independent Golgi-to-ER retrograde traffic +24654 Plcb1 True True NA +24666 Ppm1a True True NA +24668 NA True False DARPP-32 events +24672 Ppp2ca True True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;CTLA4 inhibitory signaling;RHO GTPases Activate Formins;RAF activation;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +24674 Ppp3ca True True Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation +24675 Ppp3cb True True NA +24679 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;Hedgehog 'off' state;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2;Factors involved in megakaryocyte development and platelet production +24680 Prkca False True Calmodulin induced events;Disinhibition of SNARE formation;SHC1 events in ERBB2 signaling;Signaling by SCF-KIT;Regulation of KIT signaling;EGFR Transactivation by Gastrin;Syndecan interactions;Acetylcholine regulates insulin secretion;Depolymerisation of the Nuclear Lamina;HuR (ELAVL1) binds and stabilizes mRNA;WNT5A-dependent internalization of FZD4;VEGFR2 mediated cell proliferation;Response to elevated platelet cytosolic Ca2+;RET signaling;ROBO receptors bind AKAP5 +24681 Prkcg True True Calmodulin induced events;Disinhibition of SNARE formation;WNT5A-dependent internalization of FZD4;Response to elevated platelet cytosolic Ca2+ +24686 Prnp True True NA +24688 NA False True NA +24691 NA False True Collagen degradation;Activation of Matrix Metalloproteinases;Cobalamin (Cbl, vitamin B12) transport and metabolism;Neutrophil degranulation;Antimicrobial peptides +24703 Raf1 False True Stimuli-sensing channels;Rap1 signalling;GP1b-IX-V activation signalling;CD209 (DC-SIGN) signaling;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway +24716 Ret True True RAF/MAP kinase cascade;RET signaling +24766 Scn2a True True NA +24767 Scnn1b False True Stimuli-sensing channels +24768 Scnn1g False True NA +24773 Sftpa1 False True Signal regulatory protein family interactions;Surfactant metabolism;Regulation of TLR by endogenous ligand +24778 Slc2a1 True True Cellular hexose transport;Vitamin C (ascorbate) metabolism;Regulation of insulin secretion;Lactose synthesis +24786 Sod1 True True Platelet degranulation ;Detoxification of Reactive Oxygen Species +24787 NA True False Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species +24799 NA True False NA +24803 Vamp2 True True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Clathrin derived vesicle budding;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Other interleukin signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;GABA synthesis, release, reuptake and degradation +24804 Syp True True NA +24818 NA True False Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +24825 NA True False Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation;Iron uptake and transport;Transferrin endocytosis and recycling +24826 Tg False True NA +24828 NA True False Metalloprotease DUBs +24832 NA True False Post-translational modification: synthesis of GPI-anchored proteins +24838 NA False True Striated Muscle Contraction +24849 NA True False Glycolysis +24851 NA True False NA +24854 NA True False Platelet degranulation ;Terminal pathway of complement;Antimicrobial peptides;Regulation of Complement cascade +24855 Tsc2 False True Macroautophagy;Inhibition of TSC complex formation by PKB;AKT phosphorylates targets in the cytosol;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;TBC/RABGAPs +24875 NA False True NA +24887 Bax False True Release of apoptotic factors from the mitochondria;Activation, translocation and oligomerization of BAX;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest +24888 Bcl2l1 False True NA +24896 NA True False NA +24898 Slc6a3 False True Dopamine clearance from the synaptic cleft;Na+/Cl- dependent neurotransmitter transporters +24917 NA True False NA +24923 Stx1b True True LGI-ADAM interactions +24936 NA True False Platelet degranulation ;Sperm:Oocyte Membrane Binding +24943 NA True False NA +24949 NA True False Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle +24954 Insr False True PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;Insulin receptor signalling cascade;Signaling by Insulin receptor;Insulin receptor recycling +24957 NA True False Astrocytic Glutamate-Glutamine Uptake And Metabolism;Amino acid synthesis and interconversion (transamination) +24963 NA False True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation +25009 NA True False NA +25012 Snap25 True True NA +25014 NA True False Branched-chain amino acid catabolism +25017 NA True False NA +25023 Prkcb True True NA +25027 NA False True Basigin interactions;Proton-coupled monocarboxylate transport;Pyruvate metabolism +25035 NA True False Vitamin C (ascorbate) metabolism;Phase I - Functionalization of compounds;Neutrophil degranulation +25037 NA True False NA +25050 NA False True CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde +25051 NA False True NA +25054 Ntrk2 True True Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through FRS2 and FRS3;NTRK2 activates RAC1 +25058 NA True False NA +25059 Hk2 False True Glycolysis +25062 NA True False NA +25085 Th False True Catecholamine biosynthesis +25097 Pld2 False True NA +25101 NA False True Highly sodium permeable acetylcholine nicotinic receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly calcium permeable nicotinic acetylcholine receptors +25104 NA True False Biotin transport and metabolism;Gluconeogenesis +25122 Scnn1a False True Stimuli-sensing channels +25124 NA False True Interleukin-6 signaling;ISG15 antiviral mechanism;Signaling by SCF-KIT;Downstream signal transduction;Interleukin-4 and Interleukin-13 signaling;Interferon gamma signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-27 signaling;Interleukin-21 signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling +25130 Stx2 False True NA +25135 NA False True Major pathway of rRNA processing in the nucleolus and cytosol +25152 Map1a True True NA +25176 NA True False Regulation of insulin secretion +25177 NA False True NA +25181 NA False True A tetrasaccharide linker sequence is required for GAG synthesis;Chondroitin sulfate biosynthesis;Dermatan sulfate biosynthesis;CS/DS degradation;ECM proteoglycans +25183 NA True False Rho GTPase cycle;RAB GEFs exchange GTP for GDP on RABs +25218 NA False True Retrograde transport at the Trans-Golgi-Network +25230 NA True False Miscellaneous transport and binding events +25244 NA True False NA +25246 NA True False Degradation of the extracellular matrix;Basigin interactions;Integrin cell surface interactions;Proton-coupled monocarboxylate transport;Pyruvate metabolism +25248 Cnr1 True True Class A/1 (Rhodopsin-like receptors);G alpha (i) signalling events +25252 Dlg1 True True NA +25262 Itpr1 True True Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;cGMP effects;Ion homeostasis;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +25270 NA True False ABC transporters in lipid homeostasis +25272 NA True False Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors +25274 NA True False Degradation of cysteine and homocysteine +25275 Cnp True True NA +25282 NA True False NA +25287 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA +25288 NA False True alpha-linolenic acid (ALA) metabolism;Synthesis of very long-chain fatty acyl-CoAs +25291 NA True False NA +25293 NA True False Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins +25303 Abcc2 False True ABC-family proteins mediated transport +25307 NA True False Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation +25309 NA True False NA +25316 Ms4a2 False True NA +25319 NA True False NA +25344 NA True False NA +25349 NA True False Phase 0 - rapid depolarisation +25353 Spp1 False True Degradation of the extracellular matrix;Signaling by PDGF;Integrin cell surface interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation +25356 NA True False NA +25363 NA False True NA +25368 NA True False Purine salvage +25379 NA True False NA +25380 NA False True G alpha (q) signalling events;G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands +25388 Arrb2 False True G alpha (s) signalling events;Thrombin signalling through proteinase activated receptors (PARs);WNT5A-dependent internalization of FZD4;Activation of SMO;MAP2K and MAPK activation;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis +25390 NA False True Basigin interactions;Ion homeostasis;Ion transport by P-type ATPases +25393 NA True False Degradation of the extracellular matrix;A tetrasaccharide linker sequence is required for GAG synthesis;Chondroitin sulfate biosynthesis;Dermatan sulfate biosynthesis;CS/DS degradation;ECM proteoglycans +25398 Cacna1a False True NA +25399 NA False True NA +25400 Camk2a True True NA +25413 NA False True NA +25414 Bcar1 False True NA +25415 NA True False CRMPs in Sema3A signaling +25416 Dpysl2 True True CRMPs in Sema3A signaling;Recycling pathway of L1 +25417 NA True False CRMPs in Sema3A signaling +25418 NA True False CRMPs in Sema3A signaling +25420 NA True False HSF1-dependent transactivation +25434 NA True False NA +25438 NA False True Gluconeogenesis +25448 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase +25450 NA True False GABA A receptor activation +25456 Glrb False True Neurotransmitter receptors and postsynaptic signal transmission +25459 NA True False NA +25466 NA False True PIP3 activates AKT signaling;Receptor-type tyrosine-protein phosphatases;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-36 pathway;Interleukin-33 signaling;Interleukin-1 signaling +25467 Irs1 False True NA +25468 Kcna2 True True Voltage gated Potassium channels +25470 Kcna5 False True Voltage gated Potassium channels +25473 NA True False Laminin interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MET activates PTK2 signaling;Post-translational protein phosphorylation +25485 NA True False NA +25489 Nedd4 True True ISG15 antiviral mechanism;Downregulation of ERBB4 signaling;Regulation of PTEN localization;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation +25498 NA False True NA +25506 P4hb True True Collagen biosynthesis and modifying enzymes;Detoxification of Reactive Oxygen Species;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Hedgehog ligand biogenesis;Post-translational protein phosphorylation;Chylomicron assembly;Interleukin-12 signaling +25513 Pik3r1 False True PI3K Cascade;IRS-mediated signalling;GPVI-mediated activation cascade;PI3K events in ERBB4 signaling;PIP3 activates AKT signaling;Interleukin-7 signaling;Signaling by SCF-KIT;Synthesis of PIPs at the plasma membrane;GAB1 signalosome;Downstream signal transduction;PI3K events in ERBB2 signaling;PI3K/AKT activation;Downstream TCR signaling;Role of phospholipids in phagocytosis;Tie2 Signaling;DAP12 signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Costimulation by the CD28 family;CD28 dependent PI3K/Akt signaling;G alpha (q) signalling events;GP1b-IX-V activation signalling;VEGFA-VEGFR2 Pathway;Interleukin-3, Interleukin-5 and GM-CSF signaling;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates PI3K/AKT signaling;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Interleukin receptor SHC signaling;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +25518 NA True False NA +25522 Prkcz False True TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);VEGFR2 mediated cell proliferation +25528 NA True False Cell surface interactions at the vascular wall;DAP12 interactions;Signal regulatory protein family interactions;Neutrophil degranulation +25529 NA True False NA +25531 NA True False Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs;GABA synthesis, release, reuptake and degradation +25537 NA True False EPHB-mediated forward signaling;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases Activate ROCKs +25538 NA False True L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +25551 NA True False Cellular hexose transport;Vitamin C (ascorbate) metabolism;Neutrophil degranulation +25558 Stxbp1 True True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation +25562 Tceb3 False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation +25567 Tnr True True NA +25573 Ube2i False True SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Formation of Incision Complex in GG-NER;Negative regulation of activity of TFAP2 (AP-2) family transcription factors +25576 Ywhah True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex +25577 NA True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors +25578 Ywhaz True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Deactivation of the beta-catenin transactivating complex;Rap1 signalling;GP1b-IX-V activation signalling;KSRP (KHSRP) binds and destabilizes mRNA;Interleukin-3, Interleukin-5 and GM-CSF signaling;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;NOTCH4 Activation and Transmission of Signal to the Nucleus;Regulation of localization of FOXO transcription factors +25581 Psmc2 True True NA +25594 NA True False Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate PAKs +25595 NA True False NA +25596 NA False True NA +25603 NA False True Acetylcholine regulates insulin secretion +25604 NA True False NA +25613 Ptprz1 True True Other interleukin signaling +25617 Hspa5 True True Regulation of HSF1-mediated heat shock response;Antigen Presentation: Folding, assembly and peptide loading of class I MHC +25622 Ptpn11 True True Interleukin-6 signaling;PI3K Cascade;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;GAB1 signalosome;Downstream signal transduction;Tie2 Signaling;Costimulation by the CD28 family;CTLA4 inhibitory signaling;PD-1 signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;FRS-mediated FGFR2 signaling;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;Interleukin-20 family signaling;MET activates PTPN11;Regulation of RUNX1 Expression and Activity;Interferon alpha/beta signaling;Regulation of IFNA signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon +25630 NA True False Neutrophil degranulation;Glycolysis +25632 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma +25636 Prkaca False True PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;Regulation of insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;VEGFA-VEGFR2 Pathway;CREB1 phosphorylation through the activation of Adenylate Cyclase;Interleukin-3, Interleukin-5 and GM-CSF signaling;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'off' state;Anchoring of the basal body to the plasma membrane;CD209 (DC-SIGN) signaling;MAPK6/MAPK4 signaling;AURKA Activation by TPX2;HDL assembly;Factors involved in megakaryocyte development and platelet production +25639 NA True False TGF-beta receptor signaling activates SMADs +25650 NA True False Basigin interactions;Ion homeostasis;Ion transport by P-type ATPases +25663 NA False True Interleukin-1 signaling +25669 NA True False NA +25671 NA False True NA +25673 NA True False Platelet degranulation +25686 NA True False PLC beta mediated events;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +25697 NA False True Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes +25716 NA True False Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;GABA synthesis, release, reuptake and degradation +25721 NA True False Glyoxylate metabolism and glycine degradation;Amino acid synthesis and interconversion (transamination) +25722 Scn4a False True Phase 0 - rapid depolarisation +25725 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;Hedgehog 'off' state;Factors involved in megakaryocyte development and platelet production +25728 NA True False Scavenging by Class A Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Chylomicron clearance;HDL remodeling;Retinoid metabolism and transport +25736 Kcnb1 False True Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion +25738 Plcg1 False True NA +25739 NA True False NA +25740 NA True False PLC beta mediated events;G-protein activation;G alpha (z) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +25741 NA True False Neutrophil degranulation;Glycolysis +25742 S100b True True TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Advanced glycosylation endproduct receptor signaling;TRAF6 mediated NF-kB activation +25750 NA True False Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB +25751 Dnm2 True True Gap junction degradation;Formation of annular gap junctions;NOSTRIN mediated eNOS trafficking;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Clathrin-mediated endocytosis +25897 NA False True NA +25932 NA False True NA +26192 NA False True NA +26193 NA True False Respiratory electron transport;Complex I biogenesis +26195 NA True False NA +26198 NA True False NA +26201 NA True False Respiratory electron transport;Complex I biogenesis +26202 NA True False Respiratory electron transport;Complex I biogenesis +26204 NA True False NA +26291 NA False True NA +26295 Ogt True True HATs acetylate histones;UCH proteinases +26409 NA False True NA +26519 NA False True NA +26574 AATF False True NA +26759 NA True False Mitochondrial Fatty Acid Beta-Oxidation +26900 NA False True NA +26955 NA True False NA +26956 NA True False NA +26962 NA True False NA +26989 Cadps True True NA +27041 NA False True NA +27139 NA True False NA +27367 NA False True NA +28298 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +29139 Dcn False True Degradation of the extracellular matrix;A tetrasaccharide linker sequence is required for GAG synthesis;Chondroitin sulfate biosynthesis;Dermatan sulfate biosynthesis;CS/DS degradation;ECM proteoglycans +29144 Canx True True MHC class II antigen presentation;Interleukin-35 Signalling;Calnexin/calreticulin cycle;Interleukin-27 signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC +29149 NA True False NA +29150 NA True False NA +29154 Capn2 True True Degradation of the extracellular matrix +29158 NA False True Elastic fibre formation;Molecules associated with elastic fibres +29161 Cav3 False True Smooth Muscle Contraction +29167 NA True False NA +29177 NA True False NA +29179 NA True False NA +29205 NA True False Neutrophil degranulation +29209 NA False True NA +29213 NA False True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Kinesins +29214 Tubb5 True True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;AURKA Activation by TPX2 +29219 Snca True True NA +29220 NA False True Signaling by PDGF +29221 NA False True Neutrophil degranulation;Urea cycle +29223 NA True False Interconversion of nucleotide di- and triphosphates +29224 NA True False NA +29236 NA True False NA +29254 NA True False Acyl chain remodeling of DAG and TAG;Arachidonate production from DAG +29258 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +29271 Cfl1 True True NA +29272 NA True False NA +29275 NA True False Striated Muscle Contraction +29276 NA True False NA +29278 NA True False NA +29282 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +29283 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +29284 NA True False NA +29286 NA True False NA +29287 NA True False NA +29288 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +29304 NA True False NA +29309 NA False True Ubiquinol biosynthesis +29318 NA True False NA +29331 NA True False ECM proteoglycans +29338 NA True False Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes +29340 Prkce True True NA +29366 NA False True Intrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Dissolution of Fibrin Clot +29374 NA True False Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +29376 Irs2 False True PI3K Cascade;IRS-mediated signalling;SOS-mediated signalling;PIP3 activates AKT signaling;Interleukin-7 signaling;PI3K/AKT activation;IRS-related events triggered by IGF1R;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates RAS +29382 Ctbp1 True True Deactivation of the beta-catenin transactivating complex;SUMOylation of transcription cofactors;Repression of WNT target genes +29383 NA True False NA +29384 NA True False NA +29409 NA True False Axonal growth inhibition (RHOA activation);Basigin interactions +29411 NA True False Fatty acyl-CoA biosynthesis +29423 Gap43 True True L1CAM interactions +29425 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +29428 NA True False NA +29431 Pak1 True True Generation of second messenger molecules;Regulation of actin dynamics for phagocytic cup formation;FCERI mediated MAPK activation;DSCAM interactions;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;Ephrin signaling;Sema3A PAK dependent Axon repulsion;Signal transduction by L1;Smooth Muscle Contraction;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling;G beta:gamma signalling through CDC42 +29432 Pak2 False True Generation of second messenger molecules;FCERI mediated MAPK activation;CD28 dependent Vav1 pathway;Ephrin signaling;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling +29433 Pak3 True True Generation of second messenger molecules;CD28 dependent Vav1 pathway;Ephrin signaling;Sema3A PAK dependent Axon repulsion;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling +29437 NA False True Striated Muscle Contraction +29441 NA True False NA +29443 NA True False Methylation;Sulfur amino acid metabolism +29445 NA True False NA +29448 NA True False MHC class II antigen presentation;Neutrophil degranulation;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs +29456 Map1b True True NA +29457 NA True False NA +29468 NA True False NA +29473 Aoc3 False True Phase I - Functionalization of compounds +29474 NA True False NA +29477 Mapt False True Caspase-mediated cleavage of cytoskeletal proteins +29482 NA True False NA +29483 NA True False Astrocytic Glutamate-Glutamine Uptake And Metabolism;Glutamate Neurotransmitter Release Cycle;Transport of inorganic cations/anions and amino acids/oligopeptides +29489 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2 +29491 Itsn1 True True NRAGE signals death through JNK;Rho GTPase cycle;EPHB-mediated forward signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis +29495 Dlg4 True True Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Activation of Ca-permeable Kainate Receptor;RHO GTPases activate CIT;RAF/MAP kinase cascade;LGI-ADAM interactions;Neurexins and neuroligins;Synaptic adhesion-like molecules +29507 NA True False NA +29511 NA True False NA +29521 NA True False NA +29525 NA True False NA +29527 Ptgs2 False True Nicotinamide salvaging;Synthesis of 15-eicosatetraenoic acid derivatives;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Biosynthesis of EPA-derived SPMs;Biosynthesis of DPAn-3 SPMs;Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives +29539 Aldh2 True True Ethanol oxidation +29542 Pebp1 True True MAP2K and MAPK activation;Negative regulation of MAPK pathway +29545 Uchl1 True True UCH proteinases +29546 Homer1 True True Neurexins and neuroligins +29547 Homer2 False True Neurexins and neuroligins +29548 Homer3 True True Neurexins and neuroligins +29555 NA False True G alpha (s) signalling events;Glucagon-type ligand receptors +29557 NA False True NA +29561 NA True False NA +29562 Prps1 True True 5-Phosphoribose 1-diphosphate biosynthesis +29564 Dync1i1 True True NA +29565 NA True False Peptide chain elongation;Synthesis of diphthamide-EEF2;Neutrophil degranulation;Protein methylation +29578 NA True False NA +29592 NA True False Branched-chain amino acid catabolism +29598 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases +29599 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases +29600 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases +29627 Gria2 True True NA +29628 NA True False Activation of AMPA receptors;Trafficking of AMPA receptors;Trafficking of GluR2-containing AMPA receptors;Synaptic adhesion-like molecules +29630 Psme1 False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +29635 NA False True NA +29637 NA True False Cholesterol biosynthesis +29647 Cask True True NA +29648 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Mitotic Telophase/Cytokinesis +29660 NA False True NA +29662 NA True False Rho GTPase cycle;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs +29663 NA True False MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis +29666 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +29668 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +29669 Psma2 True True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation +29670 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +29671 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +29673 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +29675 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +29677 Psmc3 True True NA +29681 NA True False Intrinsic Pathway of Fibrin Clot Formation +29682 Kcnq3 False True NA +29691 NA False True Cam-PDE 1 activation;cGMP effects;G alpha (s) signalling events +29693 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases +29699 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;Hedgehog 'off' state;Factors involved in megakaryocyte development and platelet production +29704 NA True False NA +29705 NA True False GABA A receptor activation +29715 Slc8a1 True True Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis +29738 Kcnab2 True True Voltage gated Potassium channels;Neutrophil degranulation +29748 NA True False Activation of BAD and translocation to mitochondria ;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation +29752 NA False True NA +29753 NA True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Signaling by Hippo;NADE modulates death signalling;Regulation of PLK1 Activity at G2/M Transition;Regulation of HSF1-mediated heat shock response;HSF1 activation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;RAB GEFs exchange GTP for GDP on RABs +29757 NA True False ROS, RNS production in phagocytes;Neutrophil degranulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport +50522 Ubc False True NA +50557 Pten False True Synthesis of PIPs at the plasma membrane;Synthesis of IP3 and IP4 in the cytosol;Negative regulation of the PI3K/AKT network;Downstream TCR signaling;Ub-specific processing proteases;Ovarian tumor domain proteases;Regulation of PTEN localization;Regulation of PTEN stability and activity +50567 NA True False Basigin interactions;Amino acid transport across the plasma membrane;Tryptophan catabolism +50592 Gria1 True True NA +50646 Ptk2b True True Signal regulatory protein family interactions;VEGFA-VEGFR2 Pathway;Interleukin-2 signaling +50655 NA True False NA +50663 NA True False CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;Platelet degranulation ;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;eNOS activation;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;VEGFR2 mediated vascular permeability;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Glycogen breakdown (glycogenolysis);Protein methylation;Ion transport by P-type ATPases;Activation of RAC1 downstream of NMDARs;Long-term potentiation +50664 Gnao1 True True PLC beta mediated events;G-protein activation;Ca2+ pathway;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +50671 NA True False ChREBP activates metabolic gene expression;Vitamin B5 (pantothenate) metabolism;Fatty acyl-CoA biosynthesis +50686 NA True False NA +50687 L1cam True True Basigin interactions;L1CAM interactions;Recycling pathway of L1;Interaction between L1 and Ankyrins;Signal transduction by L1 +50689 Mapk3 True True MAPK3 (ERK1) activation;RAF-independent MAPK1/3 activation;ISG15 antiviral mechanism;Spry regulation of FGF signaling;Golgi Cisternae Pericentriolar Stack Reorganization;Frs2-mediated activation;ERK/MAPK targets;ERKs are inactivated;Regulation of actin dynamics for phagocytic cup formation;Senescence-Associated Secretory Phenotype (SASP);NCAM signaling for neurite out-growth;Signal transduction by L1;Activation of the AP-1 family of transcription factors;Thrombin signalling through proteinase activated receptors (PARs);Negative regulation of FGFR1 signaling;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RNA Polymerase I Promoter Opening;Signal attenuation;Gastrin-CREB signalling pathway via PKC and MAPK;Growth hormone receptor signaling +50693 NA True False Platelet degranulation +50719 NA True False Basigin interactions;Amino acid transport across the plasma membrane;Tryptophan catabolism +50818 NA False True NA +50861 NA False True NA +50864 NA True False NA +51776 NA False True NA +51788 NA False True NA +53319 NA False True NA +53356 NA False True NA +53381 NA False True NA +54226 App True True Platelet degranulation ;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;G alpha (i) signalling events;Lysosome Vesicle Biogenesis;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Advanced glycosylation endproduct receptor signaling;Post-translational protein phosphorylation;TRAF6 mediated NF-kB activation +54231 NA True False Erythrocytes take up carbon dioxide and release oxygen;Reversible hydration of carbon dioxide +54241 NA True False NA +54245 Crk True True ARMS-mediated activation;Downstream signal transduction;Regulation of actin dynamics for phagocytic cup formation;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;MET receptor recycling;Regulation of signaling by CBL +54248 NA True False NA +54257 Grik2 False True Activation of Na-permeable kainate receptors;Activation of Ca-permeable Kainate Receptor +54293 NA False True G alpha (q) signalling events;G alpha (i) signalling events +54296 NA True False NA +54308 NA True False NA +54318 NA False True L13a-mediated translational silencing of Ceruloplasmin expression;PERK regulates gene expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP +54319 NA True False Netrin-1 signaling;Recycling pathway of L1 +54321 Cnn3 False True NA +54322 NA True False NA +54323 Arc False True NA +54348 NA True False NA +54709 NA False True NA +55172 NA False True NA +55651 NA False True NA +55803 NA False True NA +55810 NA False True NA +56003 NA True False NA +56010 NA True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Regulation of localization of FOXO transcription factors +56011 Ywhab True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;mTOR signalling;mTORC1-mediated signalling;Signaling by Hippo;Rap1 signalling;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors +56012 NA False True NA +56029 Srcin1 True True NA +56040 NA False True NA +56042 NA True False COPII-mediated vesicle transport;COPI-mediated anterograde transport +56064 NA True False NA +56084 Hgs True True NA +56086 NA False True NA +56227 Espn False True NA +56403 NA False True NA +56456 NA False True NA +56611 NA False True Neutrophil degranulation;Dissolution of Fibrin Clot +56646 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation +56718 Mtor True True PIP3 activates AKT signaling;Macroautophagy;mTOR signalling;mTORC1-mediated signalling;HSF1-dependent transactivation;Energy dependent regulation of mTOR by LKB1-AMPK;CD28 dependent PI3K/Akt signaling;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription +56768 NA True False NA +56781 NA False True Striated Muscle Contraction +56783 Eif5 True True Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit +56813 NA False True Class B/2 (Secretin family receptors);G alpha (s) signalling events +56816 Park2 False True NA +56941 NA False True NA +57048 NA False True NA +57118 NA False True NA +57120 GOPC False True NA +58814 NA True False Striated Muscle Contraction +58815 NA True False NA +58819 NA False True NA +58823 NA True False NA +58835 NA True False Serine biosynthesis +58857 NA True False Sphingolipid de novo biosynthesis;Neutrophil degranulation +58917 NA True False Scavenging of heme from plasma +58920 NA True False NA +58940 NA True False NA +58945 NA False True NA +58948 NA True False Unblocking of NMDA receptors, glutamate binding and activation;Activation of Ca-permeable Kainate Receptor;RAF/MAP kinase cascade;Neurexins and neuroligins;Synaptic adhesion-like molecules +58953 NA True False Cytosolic sulfonation of small molecules +58959 NA False True Class B/2 (Secretin family receptors);G alpha (s) signalling events +58974 Gabarap False True Macroautophagy;TBC/RABGAPs +59069 NA False True NA +59114 Slc9a3r1 True True NA +59312 Shank3 False True NA +59317 NA True False Trafficking of AMPA receptors;Neurexins and neuroligins +59322 NA True False MAP2K and MAPK activation +59323 Erbb4 False True NA +60324 NA True False NA +60331 Atxn3 False True Josephin domain DUBs;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +60335 NA False True Formation of the cornified envelope +60341 Camkk1 True True CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Activation of RAC1 downstream of NMDARs +60355 NA True False NA +60377 NA False True Dopamine Neurotransmitter Release Cycle;RHO GTPases Activate Rhotekin and Rhophilins +60383 Rbck1 False True Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Antigen processing: Ubiquitination & Proteasome degradation +60384 NA False True NA +60391 Nrxn1 True True NA +60416 NA True False NA +60431 NA True False Sphingolipid de novo biosynthesis +60432 NA False True G alpha (s) signalling events;Glucagon-type ligand receptors +60443 NA False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis +60445 Tsc1 False True Macroautophagy;Inhibition of TSC complex formation by PKB;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;TBC/RABGAPs +60465 NA True False Clathrin-mediated endocytosis +60466 NA True False NA +60562 Stx6 True True Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network +60581 NA True False NA +60666 NA True False Synthesis of PA +60668 Amph True True NA +63836 NA True False Platelet degranulation +63837 NA True False NA +63839 NA False True NA +63864 NA True False Branched-chain amino acid catabolism +63868 Hspd1 True True NA +63879 Xiap False True SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;SMAC, XIAP-regulated apoptotic response;Deactivation of the beta-catenin transactivating complex;RIPK1-mediated regulated necrosis;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Regulation of necroptotic cell death;Regulation of PTEN localization;Regulation of PTEN stability and activity +63938 NA True False Branched-chain amino acid catabolism +64001 NA True False Vitamin C (ascorbate) metabolism +64040 NA True False Carnitine synthesis +64053 NA True False NA +64057 NA True False NA +64156 NA True False NA +64157 NA True False eNOS activation +64158 Tuba1a True True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Kinesins +64159 Sptan1 True True Caspase-mediated cleavage of cytoskeletal proteins;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;Neutrophil degranulation;COPI-mediated anterograde transport +64160 NA True False NA +64161 NA True False NA +64169 NA True False NA +64185 NA True False Neutrophil degranulation +64189 NA True False Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic +64192 NA True False Phenylalanine and tyrosine catabolism +64200 NA True False FGFR2 alternative splicing;mRNA Splicing - Major Pathway +64201 NA True False NA +64202 Calr True True ER-Phagosome pathway;Scavenging by Class A Receptors;Calnexin/calreticulin cycle;Antigen Presentation: Folding, assembly and peptide loading of class I MHC +64204 NA False True Assembly of collagen fibrils and other multimeric structures;Caspase-mediated cleavage of cytoskeletal proteins;Type I hemidesmosome assembly +64205 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +64298 NA True False NA +64300 NA True False NA +64302 NA True False NA +64303 NA False True Signaling by ROBO receptors;PCP/CE pathway;RHO GTPases Activate Formins +64304 NA False True Beta oxidation of butanoyl-CoA to acetyl-CoA +64306 NA True False NA +64307 NA True False NA +64310 NA True False Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;MHC class II antigen presentation;Clathrin derived vesicle budding;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Intra-Golgi traffic +64313 NA True False Amino acid synthesis and interconversion (transamination) +64351 NA True False COPII-mediated vesicle transport;COPI-mediated anterograde transport;Intra-Golgi traffic +64352 NA True False Glutathione conjugation +64356 Nrgn True True Long-term potentiation +64363 NA False True RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway +64367 NA True False Collagen biosynthesis and modifying enzymes +64371 NA True False NA +64373 NA True False GPVI-mediated activation cascade;Rho GTPase cycle;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases Activate Formins +64392 NA True False NA +64465 Cdc42 True True GPVI-mediated activation cascade;EGFR downregulation;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;G beta:gamma signalling through CDC42;Factors involved in megakaryocyte development and platelet production +64473 NA True False Cytosolic sulfonation of small molecules +64507 NA False True NA +64515 Cdc20 False True Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;Inactivation of APC/C via direct inhibition of the APC/C complex;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;APC/C:Cdc20 mediated degradation of Cyclin B;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of Emi1;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Ub-specific processing proteases;Mitotic Prometaphase;Antigen processing: Ubiquitination & Proteasome degradation +64517 NA True False Antigen processing: Ubiquitination & Proteasome degradation +64524 NA True False NA +64525 NA True False Formation of RNA Pol II elongation complex ;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation +64526 NA True False Peroxisomal protein import +64527 NA False True Neutrophil degranulation +64533 NA True False Vitamins B6 activation to pyridoxal phosphate +64547 Bcl2l11 False True Activation of BIM and translocation to mitochondria ;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;NRAGE signals death through JNK +64551 NA True False MAPK6/MAPK4 signaling +64553 NA True False NA +64627 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +64633 NA True False NA +64635 NA True False NA +64640 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +64646 NA True False NA +64647 NA True False NA +64664 NA True False NA +64665 NA True False Synaptic adhesion-like molecules +64667 Sgta True True NA +64672 NA False True Ion homeostasis;Ion transport by P-type ATPases +64681 NA False True Neutrophil degranulation +64701 NA True False NA +64829 NA True False NA +64845 Gphn True True NA +64862 Map1lc3b False True NA +65028 NA True False NA +65033 NA True False NA +65040 Dlgap1 False True Neurexins and neuroligins +65042 NA True False NA +65046 NA True False Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance +65114 NA False True NA +65136 NA True False NA +65137 Ruvbl1 True True UCH proteinases;Ub-specific processing proteases;DNA Damage Recognition in GG-NER;Deposition of new CENPA-containing nucleosomes at the centromere +65138 NA False True UCH proteinases;Ub-specific processing proteases +65151 NA True False Threonine catabolism +65152 NA True False NA +65158 NA True False NA +65171 NA True False NA +65178 Snap91 True True NA +65179 NA True False Negative regulation of MAPK pathway;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;ESR-mediated signaling +65183 NA True False Sphingolipid de novo biosynthesis;Alpha-oxidation of phytanate +65208 NA True False CRMPs in Sema3A signaling +65218 Agap2 True True NA +65262 NA True False NA +65997 NA False True NA +66028 NA True False NA +66030 NA True False NA +66031 NA True False NA +66108 NA False True NA +66475 NA False True NA +66480 NA False True NA +66511 NA False True NA +66592 NA False True NA +66870 NA False True NA +67059 NA False True NA +67097 NA False True NA +67115 NA False True NA +67186 NA False True NA +67332 NA False True NA +67427 NA False True NA +67628 NA False True NA +67738 NA False True NA +67891 NA False True NA +67958 NA False True NA +67979 NA False True NA +68349 NA False True NA +71679 NA False True NA +72900 NA False True NA +73333 NA False True NA +73830 NA False True NA +75273 NA False True NA +75705 NA False True NA +76808 NA False True NA +78957 Shank1 True True Neurexins and neuroligins +78959 NA True False Glutathione conjugation;Formation of xylulose-5-phosphate +79011 NA True False NA +79039 NA False True NA +79117 NA True False COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic +79130 NA True False Neutrophil degranulation;GABA synthesis, release, reuptake and degradation +79131 NA False True Triglyceride catabolism +79212 NA True False Na+/Cl- dependent neurotransmitter transporters;Reuptake of GABA +79213 NA True False Na+/Cl- dependent neurotransmitter transporters;Creatine metabolism;Reuptake of GABA +79239 NA True False Heme degradation;Neutrophil degranulation;Iron uptake and transport +79244 NA False True Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import +79249 NA True False Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs +79250 NA True False Citric acid cycle (TCA cycle) +79251 NA True False Amino acid synthesis and interconversion (transamination) +79256 NA True False AUF1 (hnRNP D0) binds and destabilizes mRNA;mRNA Splicing - Major Pathway +79257 Axin1 False True NA +79433 NA True False NA +79434 Rab11b True True TBC/RABGAPs;RAB geranylgeranylation +79449 NA False True NA +79451 NA False True NA +79559 NA True False NA +80773 NA True False Phase I - Functionalization of compounds +80841 NA True False Triglyceride catabolism +80846 NA True False mRNA Splicing - Major Pathway +80849 NA True False NA +81022 Stxbp5 True True NA +81504 Grb2 True True PI3K Cascade;SOS-mediated signalling;SHC1 events in ERBB4 signaling;PIP3 activates AKT signaling;Spry regulation of FGF signaling;Signaling by SCF-KIT;Regulation of KIT signaling;Signalling to RAS;GRB2 events in EGFR signaling;GAB1 signalosome;SHC1 events in EGFR signaling;EGFR downregulation;Downstream signal transduction;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Regulation of actin dynamics for phagocytic cup formation;Tie2 Signaling;EGFR Transactivation by Gastrin;DAP12 signaling;SHC-related events triggered by IGF1R;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;GRB2:SOS provides linkage to MAPK signaling for Integrins ;NCAM signaling for neurite out-growth;Costimulation by the CD28 family;CD28 dependent Vav1 pathway;Signal regulatory protein family interactions;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;Negative regulation of MET activity;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Insulin receptor signalling cascade;MET activates RAS signaling;MET activates PI3K/AKT signaling;RET signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;MET activates PTPN11;MET activates RAP1 and RAC1;MET receptor recycling;Interleukin-15 signaling;Erythropoietin activates RAS;Activated NTRK2 signals through FRS2 and FRS3;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +81515 Lyn False True GPVI-mediated activation cascade;Signaling by SCF-KIT;Regulation of KIT signaling;Cell surface interactions at the vascular wall;FCGR activation;Fc epsilon receptor (FCERI) signaling;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;CD28 co-stimulation;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;CD209 (DC-SIGN) signaling;CD22 mediated BCR regulation;Cyclin D associated events in G1;Platelet Adhesion to exposed collagen;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates RAS;Regulation of signaling by CBL;Growth hormone receptor signaling +81529 NA False True NA +81530 NA True False NA +81531 NA True False Signaling by ROBO receptors;RHO GTPases Activate Formins +81632 NA True False Degradation of GABA +81634 NA True False Platelet degranulation ;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components +81637 Ap2a2 False True Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Neutrophil degranulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance +81643 NA True False Purine ribonucleoside monophosphate biosynthesis +81650 Csnk2b True True WNT mediated activation of DVL;Signal transduction by L1;Neutrophil degranulation;Regulation of TP53 Activity through Phosphorylation;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity +81653 Dbn1 True True NA +81654 NA True False Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism +81661 NA True False NA +81662 NA True False NA +81664 NA True False PLC beta mediated events;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +81666 NA True False NA +81667 NA True False Activation of G protein gated Potassium channels;G-protein activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +81672 Grm7 False True NA +81677 NA True False Synthesis of IP3 and IP4 in the cytosol +81682 NA False True Keratan sulfate biosynthesis;Keratan sulfate degradation;Integrin cell surface interactions +81683 NA True False Cell surface interactions at the vascular wall;Neutrophil degranulation +81708 NA True False Branched-chain amino acid catabolism +81722 Ager False True TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Advanced glycosylation endproduct receptor signaling;TRAF6 mediated NF-kB activation +81728 NA True False Respiratory electron transport;Complex I biogenesis +81732 NA True False Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis +81743 NA True False cGMP effects;G alpha (s) signalling events +81753 NA False True NA +81754 NA True False Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs +81757 Rala True True Translocation of SLC2A4 (GLUT4) to the plasma membrane +81761 NA True False NA +81763 NA True False NA +81764 NA True False NA +81765 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +81766 NA True False NA +81767 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +81768 NA False True NA +81772 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +81773 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +81774 NA False True NA +81779 NA False True NA +81783 NA False True NA +81800 NA True False NA +81802 Stx3 False True Other interleukin signaling +81804 Stxbp2 False True NA +81807 Tceb2 True True Formation of RNA Pol II elongation complex ;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation +81815 NA True False Antigen processing: Ubiquitination & Proteasome degradation +81818 NA True False NA +81822 Actb True True Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Adherens junctions interactions;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;B-WICH complex positively regulates rRNA expression;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;MAP2K and MAPK activation;UCH proteinases;DNA Damage Recognition in GG-NER;Clathrin-mediated endocytosis +81824 NA True False NA +81827 Psmc5 True True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +81829 NA True False Citric acid cycle (TCA cycle) +81869 NA True False Glutathione conjugation +81898 NA False True NA +81921 NA True False EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis +81922 Sh3gl1 True True EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis +83422 NA False True NA +83427 NA True False Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production +83471 NA True False NA +83501 NA True False NA +83506 Camkk2 False True NA +83510 NA True False L1CAM interactions +83523 NA True False NA +83527 NA True False Caspase-mediated cleavage of cytoskeletal proteins;Neurexins and neuroligins;Neutrophil degranulation +83529 Vdac1 True True Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases;Pyruvate metabolism +83531 NA True False Ub-specific processing proteases +83532 NA True False NA +83533 NA False True NA +83534 NA True False NA +83572 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2 +83576 NA True False Golgi Associated Vesicle Biogenesis +83578 NA True False NA +83579 NA True False NA +83589 Apba1 False True NA +83610 Apba2 False True NA +83612 NA True False Transport of inorganic cations/anions and amino acids/oligopeptides;GABA synthesis, release, reuptake and degradation +83613 Nefl True True Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade +83615 NA True False NA +83616 NA True False NA +83688 NA True False Pentose phosphate pathway +83707 NA False True NA +83709 Git1 True True NA +83712 NA True False PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;PKMTs methylate histone lysines;HATs acetylate histones;RMTs methylate histone arginines;Deposition of new CENPA-containing nucleosomes at the centromere;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Neddylation;Transcriptional Regulation by E2F6 +83718 Clic4 True True NA +83725 Wfs1 False True NA +83731 Kcnma1 True True Ca2+ activated K+ channels +83764 NA True False Synaptic adhesion-like molecules +83765 Rtn4 True True Axonal growth inhibition (RHOA activation) +83782 Nme2 True True Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation +83788 NA True False NA +83789 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;RMTs methylate histone arginines;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Protein methylation;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +83800 Clta True True Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance +83806 NA True False NA +83807 NA False True NA +83809 Nsfl1c True True NA +83823 NA True False NA +83824 Cxxc4 False True NA +83825 NA True False NA +83839 NA True False NA +83841 Sdcbp False True Ephrin signaling;Neurofascin interactions;Neutrophil degranulation +84008 NA True False NA +84013 NA False True Androgen biosynthesis;Synthesis of very long-chain fatty acyl-CoAs +84014 NA False True NA +84016 NA False True NA +84027 Gsk3b False True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;CRMPs in Sema3A signaling;Disassembly of the destruction complex and recruitment of AXIN to the membrane;B-WICH complex positively regulates rRNA expression +84309 NA False True NA +84310 NA False True NA +84353 Ctnnb1 True True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;TCF dependent signaling in response to WNT;Formation of the beta-catenin:TCF transactivating complex;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Apoptotic cleavage of cell adhesion proteins;CDO in myogenesis;Deactivation of the beta-catenin transactivating complex;Ca2+ pathway;Adherens junctions interactions;VEGFR2 mediated vascular permeability;RHO GTPases activate IQGAPs;RUNX3 regulates WNT signaling +84356 NA False True NA +84379 NA True False Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs +84431 NA True False Glycosphingolipid metabolism;Neutrophil degranulation +84469 Maged1 False True NA +84471 NA True False NA +84472 NA True False NA +84474 NA True False NA +84478 Ufd1l False True Translesion Synthesis by POLH;Ub-specific processing proteases +84479 NA False True NA +84484 NA True False Bicarbonate transporters +84496 NA False True NA +84509 NA True False NA +84550 NA True False Sodium/Calcium exchangers +84556 NA True False Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation +84591 Pick1 False True NA +84685 Ppp1r9a True True NA +84686 NA True False NA +85238 Synj1 True True Synthesis of PIPs at the plasma membrane;Synthesis of IP2, IP, and Ins in the cytosol;Synthesis of IP3 and IP4 in the cytosol;Clathrin-mediated endocytosis +85252 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Deactivation of the beta-catenin transactivating complex;HuR (ELAVL1) binds and stabilizes mRNA;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;Mitotic Prometaphase;Cyclin A/B1/B2 associated events during G2/M transition +85254 NA True False Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Choline catabolism +85309 NA True False NA +85327 Lin7a True True NA +85333 NA True False NA +85492 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation +89789 NA False True NA +89791 NA True False NA +89841 NA True False Synthesis of PE +89953 NA False True NA +90933 NA False True NA +93646 NA True False COPII-mediated vesicle transport;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC +94167 Prdx6 True True Detoxification of Reactive Oxygen Species;Neutrophil degranulation +94173 NA True False Citric acid cycle (TCA cycle) +94193 NA True False Regulation of TNFR1 signaling;RAB GEFs exchange GTP for GDP on RABs +94194 NA True False NA +94197 NA True False Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs +94266 NA False True NA +97165 NA False True NA +98221 NA False True NA +98238 NA False True NA +101706 NA False True NA +107686 NA False True NA +107932 NA False True NA +108017 NA False True NA +108071 NA False True NA +108989 NA False True NA +110611 NA False True NA +110954 NA False True NA +110957 NA False True NA +112295 Lmb1 False True NA +113893 NA True False NA +113894 Sqstm1 False True NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Pink/Parkin Mediated Mitophagy;Interleukin-1 signaling +113898 NA True False NA +113965 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA +113970 Magi2 False True NA +114005 NA False True Glycogen synthesis +114017 NA False True Mitochondrial translation elongation +114023 NA False True Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic +114096 NA True False NA +114101 NA True False NA +114114 Dnm1l True True Apoptotic execution phase +114122 NA True False NA +114202 NA True False NA +114486 Braf False True NA +114513 NA True False NA +114514 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase +114515 NA True False NA +114520 NA True False NA +114562 NA True False NA +114591 NA True False NA +114597 NA True False NA +114612 NA True False Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing +114641 NA False True NA +114766 NA True False Processing of SMDT1 +115769 NA False True Signaling by Hippo;Apoptotic cleavage of cell adhesion proteins +116463 NA True False Estrogen biosynthesis;Retinoid metabolism and transport +116470 Stx1a True True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Other interleukin signaling;LGI-ADAM interactions;GABA synthesis, release, reuptake and degradation +116482 NA True False Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the Golgi membrane +116483 NA True False NA +116484 NA True False NA +116493 NA True False NA +116506 NA False True G alpha (s) signalling events;Calcitonin-like ligand receptors +116508 Nrxn3 True True NA +116509 NA True False Na+/Cl- dependent neurotransmitter transporters +116549 Csnk2a1 True True WNT mediated activation of DVL;Signal transduction by L1;Regulation of TP53 Activity through Phosphorylation;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity +116561 NA True False Gap junction degradation;Formation of annular gap junctions;Lysosome Vesicle Biogenesis;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis +116563 NA True False Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance +116590 Mapk1 True True phospho-PLA2 pathway;RAF-independent MAPK1/3 activation;MAPK1 (ERK2) activation;Spry regulation of FGF signaling;Golgi Cisternae Pericentriolar Stack Reorganization;Frs2-mediated activation;ERK/MAPK targets;ERKs are inactivated;Regulation of actin dynamics for phagocytic cup formation;Senescence-Associated Secretory Phenotype (SASP);NCAM signaling for neurite out-growth;Recycling pathway of L1;Signal transduction by L1;Activation of the AP-1 family of transcription factors;Thrombin signalling through proteinase activated receptors (PARs);Negative regulation of FGFR1 signaling;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Neutrophil degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Gastrin-CREB signalling pathway via PKC and MAPK;Growth hormone receptor signaling +116595 Nrxn2 True True Neurexins and neuroligins +116597 NA True False NA +116598 Pdia4 False True NA +116599 NA True False Heme degradation +116636 NA False True mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S +116638 NA True False Glutamate Neurotransmitter Release Cycle;Organic anion transporters +116643 Vcp True True Translesion Synthesis by POLH;HSF1 activation;ABC-family proteins mediated transport;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Hedgehog ligand biogenesis;Josephin domain DUBs;Ovarian tumor domain proteases;Neutrophil degranulation +116644 Rtn1 True True NA +116646 NA True False NA +116653 NA True False NA +116655 Hnrnpm True True FGFR2 alternative splicing;mRNA Splicing - Major Pathway +116657 NA True False NA +116673 NA False True A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG biosynthesis;HS-GAG degradation;Cell surface interactions at the vascular wall;Syndecan interactions;Retinoid metabolism and transport +116685 Lmnb1 True True NA +116690 Nfasc True True Neurofascin interactions;Neutrophil degranulation +116698 NA True False Generic Transcription Pathway +116723 NA True False NA +116725 NA True False ISG15 antiviral mechanism;NOD1/2 Signaling Pathway;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;CLEC7A (Dectin-1) signaling;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;E3 ubiquitin ligases ubiquitinate target proteins;Interleukin-1 signaling;IRAK1 recruits IKK complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation +116743 Sh3gl2 True True Retrograde neurotrophin signalling;EGFR downregulation;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis +117024 NA True False NA +117028 Bin1 True True Clathrin-mediated endocytosis +117030 NA True False NA +117042 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +117044 NA True False Macroautophagy;mTOR signalling;mTORC1-mediated signalling;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;E3 ubiquitin ligases ubiquitinate target proteins;Regulation of PTEN gene transcription +117053 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +117056 H3f3b True True PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production +117099 NA False True Synthesis of Ketone Bodies +117104 NA True False Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +117152 Cand1 True True Neutrophil degranulation;Neddylation;Iron uptake and transport +117180 NA True False NA +117243 NA True False Synthesis of very long-chain fatty acyl-CoAs +117254 NA True False Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes +117258 NA True False NA +117262 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +117263 Psmc1 True True Autodegradation of Cdh1 by Cdh1:APC/C;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +117272 NA True False NA +117273 Rhoa True True GPVI-mediated activation cascade;Axonal growth inhibition (RHOA activation);Rho GTPase cycle;PI3K/AKT activation;Axonal growth stimulation;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);G beta:gamma signalling through PI3Kgamma;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;PCP/CE pathway;G alpha (12/13) signalling events;Sema4D mediated inhibition of cell attachment and migration;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases Activate ROCKs;RHO GTPases Activate Formins;RHO GTPases Activate Rhotekin and Rhophilins;Ovarian tumor domain proteases;ERBB2 Regulates Cell Motility;Neutrophil degranulation;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;SLIT2:ROBO1 increases RHOA activity +117277 Epn1 True True NA +117282 NA True False mRNA Splicing - Major Pathway +117284 Lrrc7 True True Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade;Neutrophil degranulation +117287 Park7 True True SUMOylation of transcription cofactors +117515 NA True False Anchoring of the basal body to the plasma membrane +117520 NA True False NA +117526 Tbp False True B-WICH complex positively regulates rRNA expression;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA polymerase II transcribes snRNA genes;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase I Transcription Termination;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;Estrogen-dependent gene expression +117533 NA True False NA +117542 Baiap2 True True Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs +117543 NA True False mitochondrial fatty acid beta-oxidation of unsaturated fatty acids +117548 NA True False COPI-dependent Golgi-to-ER retrograde traffic;Kinesins +117550 NA True False MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins +117556 NA True False NA +117557 NA True False Striated Muscle Contraction;Smooth Muscle Contraction +117559 NA True False NA +117596 NA True False ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport +122772 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +122799 NA True False NA +124323 NA True False NA +124461 NA True False Clathrin-mediated endocytosis +126308 NA False True NA +140290 NA False True NA +140447 NA True False NA +140448 NA True False Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis +140547 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA +140593 Siah2 False True Netrin-1 signaling;Ub-specific processing proteases;Antigen processing: Ubiquitination & Proteasome degradation +140597 NA False True NA +140608 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation +140639 Nploc4 False True NA +140654 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +140655 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +140661 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +140662 NA False True NA +140667 NA True False NA +140670 Ap2b1 True True Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance +140671 NA False True Glycogen breakdown (glycogenolysis) +140673 NA True False COPII-mediated vesicle transport;Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network +140694 Dnm1 True True Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;Recycling pathway of L1;Clathrin-mediated endocytosis +140722 Caskin1 True True NA +140729 NA True False NA +140734 NA True False Activation of BMF and translocation to mitochondria;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Macroautophagy;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Intraflagellar transport;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase +140868 NA True False Triglyceride catabolism;Signaling by Retinoic Acid;Neutrophil degranulation +140908 Cdk5 True True DARPP-32 events;CRMPs in Sema3A signaling;Regulation of TP53 Activity through Phosphorylation +140922 NA True False NA +140926 Daxx False True SUMOylation of transcription cofactors;Regulation of TP53 Degradation +140927 NA True False NA +140931 NA False True NA +140941 Siah1 False True Netrin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation +140945 NA True False Synaptic adhesion-like molecules +146227 NA False True NA +148252 NA False True NA +154968 NA True False NA +155151 NA True False NA +156275 NA True False Aflatoxin activation and detoxification +157074 NA True False Citric acid cycle (TCA cycle) +161475 Psmd9 True True NA +161477 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +170082 NA False True NA +170465 NA True False NA +170538 Prkcd False True NA +170587 NA True False NA +170667 NA True False ROS, RNS production in phagocytes;Neutrophil degranulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport +170670 NA True False Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA +170673 NA True False NA +170724 NA True False NA +170751 NA True False NA +170821 Atxn10 False True NA +170840 Slc40a1 False True Metal ion SLC transporters;Iron uptake and transport +170848 Kcnq2 False True NA +170851 Map2k1 True True NA +170915 Ep300 False True NA +170916 NA True False NA +170923 NA True False Neutrophil degranulation +170930 NA False True NA +171026 NA False True Trafficking of AMPA receptors;ROBO receptors bind AKAP5 +171039 NA True False NA +171041 Klc1 True True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins +171050 Mob4 False True NA +171058 NA True False RAB geranylgeranylation +171082 NA False True Formation of ATP by chemiosmotic coupling;Cristae formation +171086 Trak2 False True NA +171093 NA True False NA +171102 Cdc25a False True NA +171103 Cdc25b False True NA +171114 NA True False NA +171116 NA True False Regulation of Apoptosis +171119 NA True False NA +171129 NA True False NA +171137 NA True False KSRP (KHSRP) binds and destabilizes mRNA +171140 NA True False HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Interferon gamma signaling;Ion transport by P-type ATPases +171155 NA True False Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA +171297 NA True False Neurexins and neuroligins +171337 NA True False NA +171350 Pabpc1 True True L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +171361 NA True False NA +171373 NA True False NA +171374 NA True False NA +171375 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation +171410 NA True False Synthesis of very long-chain fatty acyl-CoAs +171444 NA True False NA +171445 NA True False NA +171451 NA True False Phase I - Functionalization of compounds +171503 NA True False Activation of RAC1 downstream of NMDARs +171574 NA True False MHC class II antigen presentation;Recycling pathway of L1;Clathrin-mediated endocytosis +191575 NA True False Interconversion of nucleotide di- and triphosphates +191576 NA True False Synthesis of very long-chain fatty acyl-CoAs +191595 NA True False NA +192117 NA False True Regulation of RAS by GAPs +192152 Tgoln2 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Golgi Associated Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation +192172 NA True False Degradation of cysteine and homocysteine +192176 NA False True NA +192179 NA True False NA +192213 NA True False NA +192226 NA False True NA +192235 Hyou1 True True NA +192241 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation +192245 Hspb6 False True NA +192249 NA True False Factors involved in megakaryocyte development and platelet production +192253 NA True False NA +192254 Grasp False True NA +192255 NA False True NA +192260 NA True False Synthesis of PI +192268 NA True False Glutamate Neurotransmitter Release Cycle;TP53 Regulates Metabolic Genes;Amino acid synthesis and interconversion (transamination) +192277 NA True False HSP90 chaperone cycle for steroid hormone receptors (SHR) +192645 NA True False NA +192647 NA False True NA +201097 NA True False NA +208691 NA False True NA +217337 NA False True NA +217737 NA False True NA +218490 NA False True NA +223696 NA False True NA +228410 NA False True NA +229279 NA False True NA +230908 NA False True NA +231887 NA False True NA +234594 NA False True NA +245709 NA True False Insulin processing;VxPx cargo-targeting to cilium +245955 NA False True Platelet degranulation +245965 NA True False NA +245981 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +246118 Tubb3 True True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins +246136 NA False True NA +246302 NA True False NA +246303 NA True False NA +246307 NA True False Phenylalanine and tyrosine catabolism +246310 Arfgap1 True True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Clathrin-mediated endocytosis +246755 NA True False NA +246757 Klhl17 False True NA +246772 NA True False NA +252881 NA True False Insulin processing;VxPx cargo-targeting to cilium +252892 NA True False LGI-ADAM interactions +252902 NA True False NA +252919 NA True False Amino acid transport across the plasma membrane +252921 NA False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 +252922 NA True False NA +252934 NA True False NA +259242 NA True False Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs +259269 NA True False NA +259274 NA True False Inactivation, recovery and regulation of the phototransduction cascade;Activation, myristolyation of BID and translocation to mitochondria +260321 NA True False HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;ESR-mediated signaling;Estrogen-dependent gene expression +261736 NA True False DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation +261737 NA True False NA +266759 Hspa4 True True NA +266777 NA True False NA +266975 NA True False NA +267019 NA False True NA +268373 NA False True NA +269610 NA False True NA +276770 NA False True NA +281165 NA False True NA +281296 NA False True NA +282587 NA True False NA +282827 Aip False True Aryl hydrocarbon receptor signalling +282843 Sorbs3 False True Smooth Muscle Contraction +284273 NA False True NA +286761 NA True False Ovarian tumor domain proteases +286770 DNAJC3 False True NA +286906 NA True False Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation +286911 NA False True NA +286928 NA False True NA +286930 NA True False NA +287061 NA True False NA +287069 NA True False NA +287115 NA True False NA +287155 Stub1 False True Downregulation of TGF-beta receptor signaling;Downregulation of ERBB2 signaling;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation +287156 NA True False Rho GTPase cycle +287191 NA True False NA +287276 NA True False COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Chylomicron assembly;Antigen Presentation: Folding, assembly and peptide loading of class I MHC +287379 NA False True Carnitine synthesis +287417 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +287444 NA True False Hypusine synthesis from eIF5A-lysine +287446 NA False True NA +287535 NA False True Retrograde transport at the Trans-Golgi-Network +287633 NA True False NA +287670 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation +287702 NA False True Keratinization;Formation of the cornified envelope +287716 Psme3 False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +287721 NA True False Neutrophil degranulation +287876 NA False True Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Adherens junctions interactions;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;MAP2K and MAPK activation;Clathrin-mediated endocytosis +287877 NA False True NA +287927 NA True False Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;E3 ubiquitin ligases ubiquitinate target proteins;Antigen processing: Ubiquitination & Proteasome degradation +287931 Ppm1f True True NA +287984 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation +287986 NA False True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;mTORC1-mediated signalling;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +288064 NA False True Activation of DNA fragmentation factor +288174 NA True False Neutrophil degranulation +288275 Hunk False True NA +288444 NA True False Regulation of HSF1-mediated heat shock response +288599 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit +288620 NA False True Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +288666 NA True False WNT ligand biogenesis and trafficking +288707 NA True False Glycosphingolipid metabolism +288778 NA True False Neutrophil degranulation +288912 NA True False Methionine salvage pathway +289019 NA True False NA +289125 NA True False Mitochondrial Fatty Acid Beta-Oxidation +289144 NA True False NA +289218 NA True False Respiratory electron transport;Complex I biogenesis +289222 NA True False NA +289257 NA False True NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport +289668 NA True False NA +289820 NA True False Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis +289950 NA True False Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism +290029 NA True False Neutrophil degranulation;Purine catabolism +290356 NA True False NA +290364 Itm2b False True NA +290401 NA True False Glutathione conjugation +290408 NA True False The NLRP3 inflammasome +290640 NA True False NA +290641 NA True False NA +290651 NA True False Synthesis of IP2, IP, and Ins in the cytosol +290823 Erlin2 False True ABC-family proteins mediated transport +290868 NA False True NA +290880 NA False True NA +291075 NA True False Beta-oxidation of very long chain fatty acids;Peroxisomal protein import +291081 NA False True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins +291103 NA True False NA +291145 NA False True NA +291152 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +291180 NA True False NA +291394 NA True False Glutathione synthesis and recycling +291434 NA True False NA +291450 NA True False Choline catabolism;Lysine catabolism +291671 Hspa9 False True Regulation of HSF1-mediated heat shock response +291796 NA False True Ub-specific processing proteases +291874 Nup93 False True Transport of Mature mRNA derived from an Intron-Containing Transcript;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of DNA replication proteins +291877 NA False True Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs +291926 NA False True NA +291948 NA True False Neutrophil degranulation +292023 NA True False NA +292072 NA True False Neutrophil degranulation;Purine salvage +292148 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit +292156 NA True False NA +292267 NA True False NA +292597 NA True False Stimuli-sensing channels +292732 Numbl True True NA +292804 NA True False Neutrophil degranulation;Glycolysis +292845 NA True False Respiratory electron transport;Protein methylation +292925 Tsg101 True True Endosomal Sorting Complex Required For Transport (ESCRT) +292994 NA False True NA +293448 NA True False NA +293481 NA True False NA +293484 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit +293508 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;Regulation of insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;VEGFA-VEGFR2 Pathway;CREB1 phosphorylation through the activation of Adenylate Cyclase;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'off' state;CD209 (DC-SIGN) signaling;MAPK6/MAPK4 signaling;HDL assembly;Factors involved in megakaryocyte development and platelet production +293621 Hras True True Activation of RAS in B cells;SHC1 events in ERBB4 signaling;Signaling by SCF-KIT;p38MAPK events;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;Downstream signal transduction;GRB2 events in ERBB2 signaling;Tie2 Signaling;EGFR Transactivation by Gastrin;DAP12 signaling;FCERI mediated MAPK activation;NCAM signaling for neurite out-growth;EPHB-mediated forward signaling;VEGFR2 mediated cell proliferation;CD209 (DC-SIGN) signaling;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Regulation of RAS by GAPs;RAF activation;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative regulation of MAPK pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAS signaling +293684 NA False True NA +293692 NA True False Factors involved in megakaryocyte development and platelet production +293705 Otub1 True True Ub-specific processing proteases;Ovarian tumor domain proteases +293719 NA False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle +293725 NA True False NA +293860 NA False True Platelet degranulation ;GP1b-IX-V activation signalling;Cell-extracellular matrix interactions;RHO GTPases activate PAKs +294010 NA True False MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2 +294239 NA True False eNOS activation +294254 NA True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation +294282 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +294292 NA True False Synthesis of pyrophosphates in the cytosol +294320 NA True False Pyruvate metabolism +294326 NA True False NA +294362 NA True False NA +294568 Wasf1 True True Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs +294810 NA True False NA +294864 NA True False NA +294917 NA False True Oxidative Stress Induced Senescence +294930 NA True False LDL clearance +294972 NA False True NA +295230 NA True False Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +295277 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +295347 NA False True ARMS-mediated activation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;MAP2K and MAPK activation;Neutrophil degranulation;MET activates RAP1 and RAC1 +295619 NA True False NA +295645 NA True False Bicarbonate transporters +295690 NA False True NA +295929 Mybpc3 False True Striated Muscle Contraction +296131 NA True False NA +296197 NA False True NA +296267 NA True False NA +296318 NA True False NA +296344 NA False True NA +296369 NA False True Striated Muscle Contraction +296480 NA True False NA +296488 NA True False Platelet degranulation +296554 NA True False NA +296570 NA False True NA +296596 NA True False NA +296709 NA True False NA +296710 NA True False NA +296758 NA True False NA +297113 NA False True NA +297428 NA False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic +297436 NA True False NA +297518 NA False True Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis +297566 NA True False NA +297593 NA False True Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes +297699 NA True False Downregulation of TGF-beta receptor signaling +297994 Bag1 False True NA +298012 Rad23b True True N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Josephin domain DUBs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER +298079 NA True False NA +298101 NA True False Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;MET activates PTK2 signaling;Collagen chain trimerization +298203 NA True False Processing of SMDT1 +298410 NA True False Interconversion of nucleotide di- and triphosphates +298584 NA True False MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Factors involved in megakaryocyte development and platelet production +298596 NA True False Citric acid cycle (TCA cycle) +298609 NA True False NA +298771 NA True False NA +298848 NA True False NA +298917 NA True False NA +298942 NA True False Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Glycine degradation;Pyruvate metabolism;Branched-chain amino acid catabolism;Lysine catabolism +299027 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP +299052 NA False True Platelet degranulation ;Neutrophil degranulation;Gluconeogenesis +299194 NA True False NA +299201 NA True False Glyoxylate metabolism and glycine degradation;Lysine catabolism +299331 Hsp90aa1 True True Signaling by ERBB2;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression +299809 NA True False Association of TriC/CCT with target proteins during biosynthesis;Neutrophil degranulation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +299850 NA True False MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2 +299872 NA False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit +299923 NA True False NA +299971 NA True False ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport +300033 NA True False NA +300079 NA True False NA +300111 NA True False NA +300218 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins +300228 NA False True NA +300247 NA False True Keratinization;Formation of the cornified envelope +300250 NA False True Neutrophil degranulation;Keratinization;Formation of the cornified envelope +300677 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation +300724 NA False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation +300726 NA True False Respiratory electron transport +300850 NA True False NA +300968 NA True False Antigen processing: Ubiquitination & Proteasome degradation +300981 NA True False Aflatoxin activation and detoxification +301011 NA True False NA +301252 NA True False Regulation of actin dynamics for phagocytic cup formation;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Sema3A PAK dependent Axon repulsion;Neutrophil degranulation;The NLRP3 inflammasome;The role of GTSE1 in G2/M progression after G2 checkpoint;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression +301384 NA True False Branched-chain amino acid catabolism +301442 Sumo1 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;Regulation of IFNG signaling;Negative regulation of activity of TFAP2 (AP-2) family transcription factors +301458 NA True False Respiratory electron transport;Complex I biogenesis +301555 Cul3 True True Degradation of DVL;Hedgehog 'on' state;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation +301618 NA True False NA +302328 NA False True NA +302395 NA False True NA +302500 NA False True NA +302796 NA True False NA +302965 NA False True NA +303222 NA True False Rho GTPase cycle +303306 Srr True True Serine biosynthesis +303634 NA True False NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs) +303831 NA True False ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit +304017 NA True False Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases +304469 Rilpl1 False True NA +304542 NA False True NA +304656 NA False True NA +304805 NA True False NA +305021 NA True False Platelet degranulation +305177 NA True False Methionine salvage pathway +305178 NA False True NA +305227 NA True False NA +305288 NA False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 +305332 NA False True NA +305457 NA True False NA +305501 NA False True NA +305614 Sptbn1 False True NA +305679 NA True False Platelet degranulation ;Smooth Muscle Contraction;MAP2K and MAPK activation;Neutrophil degranulation +306327 NA False True NA +306332 Ap1m1 True True MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation +306439 NA True False NA +306626 NA False True NA +306840 NA True False NA +306934 NA True False NA +307039 NA True False Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs +307309 Sncaip False True NA +307351 NA False True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins +307503 NA False True Eukaryotic Translation Termination;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +307511 Cdc25c False True Polo-like kinase mediated events;RHO GTPases activate PKNs;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;Cyclin A/B1/B2 associated events during G2/M transition;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex +307779 NA True False NA +307821 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation +308100 NA True False NA +308113 NA False True NA +308571 NA True False Receptor-type tyrosine-protein phosphatases +308578 Ap2a1 False True Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance +308650 NA True False mRNA Splicing - Major Pathway +308690 Ndn False True NA +308709 NA False True NA +308759 NA False True NA +308901 Trim21 False True Regulation of innate immune responses to cytosolic DNA;Antigen processing: Ubiquitination & Proteasome degradation +309168 Map3k11 False True RAF activation +309557 NA False True Neurexins and neuroligins +309774 Gopc False True NA +309901 NA True False NA +310635 NA True False NRAGE signals death through JNK;Rho GTPase cycle +310820 NA True False NA +311020 NA True False NA +311078 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation +311328 NA True False NA +311422 NA True False Purine catabolism +311621 NA True False NA +311671 NA False True NA +311786 Traf2 False True Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;Ub-specific processing proteases;Dimerization of procaspase-8;TNF signaling +311848 NA True False NA +311849 NA False True Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import +311860 Abl1 False True Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;Role of ABL in ROBO-SLIT signaling;RHO GTPases Activate WASPs and WAVEs;HDR through Single Strand Annealing (SSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Cyclin D associated events in G1;RUNX1 regulates transcription of genes involved in differentiation of HSCs +311913 NA False True RAB GEFs exchange GTP for GDP on RABs +312083 NA False True NA +312444 NA True False NA +312694 Necap1 True True Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis +312965 Ubxn2b False True NA +313047 NA True False NA +313052 NA False True Neurexins and neuroligins +313200 NA False True NA +313234 NA True False TBC/RABGAPs +313323 NA True False NA +313413 NA True False NA +313474 Eps15 False True NA +313647 NA True False NA +313658 NA True False NA +313867 NA True False NA +313934 NA False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis +314140 NA True False 5-Phosphoribose 1-diphosphate biosynthesis +314432 NA True False Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation +314442 NA True False NA +314641 NA True False Synthesis of PIPs at the plasma membrane;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Clathrin-mediated endocytosis +314721 NA True False NA +314764 Eea1 False True NA +314856 Mdm2 False True AKT phosphorylates targets in the cytosol;Oxidative Stress Induced Senescence;Oncogene Induced Senescence;SUMOylation of ubiquitinylation proteins;Trafficking of AMPA receptors;Ub-specific processing proteases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Stabilization of p53;Regulation of RUNX3 expression and activity +314906 NA True False NA +315159 Tob2 False True NA +315265 NA True False NA +315509 NA True False Cell surface interactions at the vascular wall;Integrin cell surface interactions +315608 NA False True Antigen processing: Ubiquitination & Proteasome degradation +315648 NA True False Inhibition of replication initiation of damaged DNA by RB1/E2F1;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;CTLA4 inhibitory signaling;RHO GTPases Activate Formins;RAF activation;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition +315771 NA False True NA +315840 NA False True NA +315989 NA False True NA +316123 NA False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;Estrogen-dependent gene expression +316258 Cd2ap False True NA +316531 NA True False Platelet degranulation ;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Kinesins +316632 NA True False Respiratory electron transport;Complex I biogenesis +316740 NA False True NA +317259 NA True False NA +319177 NA False True NA +319184 NA False True NA +319189 NA False True NA +319190 NA False True NA +319195 NA False True NA +353227 Zbtb16 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation +360471 Usp7 True True NA +360504 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma +360543 NA False True NA +360572 NA True False NA +360593 NA True False NA +360643 Cdc27 False True Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation +360678 NA True False Axonal growth inhibition (RHOA activation);Rho GTPase cycle;Axonal growth stimulation +360687 NA True False NA +360820 Pxn False True GAB1 signalosome;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases +360853 NA False True UCH proteinases +360854 NA False True Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis +360882 NA True False Adherens junctions interactions;Nectin/Necl trans heterodimerization +360887 NA False True NA +360891 NA False True Signaling by ROBO receptors +360915 NA True False DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation +360921 NA True False NA +360950 NA True False Platelet degranulation +360975 NA True False Glyoxylate metabolism and glycine degradation;Lysine catabolism +361118 NA True False NA +361351 NA True False NA +361370 NA False True Neutrophil degranulation +361388 NA False True NA +361422 NA True False Neutrophil degranulation +361433 NA True False Glycerophospholipid biosynthesis +361503 NA False True NA +361527 NA True False Role of phospholipids in phagocytosis +361532 NA True False NA +361585 NA False True Antigen processing: Ubiquitination & Proteasome degradation +361596 NA True False Transcriptional activation of mitochondrial biogenesis;Citric acid cycle (TCA cycle) +361613 NA True False Cyclin A/B1/B2 associated events during G2/M transition +361663 NA True False Purine ribonucleoside monophosphate biosynthesis +361675 NA True False NA +361677 Tollip True True Neutrophil degranulation;Interleukin-1 signaling +361684 NA True False NA +361791 NA False True NA +361833 NA True False NA +361884 NA False True Biotin transport and metabolism;Branched-chain amino acid catabolism +361967 NA True False ESR-mediated signaling +361970 Trim2 True True NA +362013 NA True False Ion homeostasis +362015 NA True False Purine salvage +362036 Ank2 False True NA +362152 NA True False mRNA Splicing - Major Pathway +362182 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation +362245 Map1lc3a True True Macroautophagy;Pink/Parkin Mediated Mitophagy;Receptor Mediated Mitophagy +362332 NA False True Cell-extracellular matrix interactions +362361 NA True False NA +362401 NA False True NA +362440 NA True False Respiratory electron transport;Complex I biogenesis +362479 NA False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation +362587 Macf1 True True NA +362595 NA False True NA +362631 NA True False NA +362634 NA False True Initial triggering of complement;Classical antibody-mediated complement activation;Regulation of Complement cascade +362721 Tssc1 True True NA +362738 NA False True NA +362750 NA True False NA +362809 NA True False Synthesis of Prostaglandins (PG) and Thromboxanes (TX);HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression +362816 NA True False NA +362817 Cdk2 False True G0 and Early G1;Activation of ATR in response to replication stress;Regulation of APC/C activators between G1/S and early anaphase;SCF(Skp2)-mediated degradation of p27/p21;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Processing of DNA double-strand break ends;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Degradation;G2 Phase;Orc1 removal from chromatin;Activation of the pre-replicative complex;CDK-mediated phosphorylation and removal of Cdc6;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates Cell Cycle +362826 Atcay True True NA +362849 March2 False True NA +362855 NA True False NA +362862 Hsp90b1 True True NA +362950 NA True False FGFR2 alternative splicing +362965 Rangap1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Mitotic Prometaphase +362969 NA False True NA +363024 NA True False Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Neutrophil degranulation +363113 NA True False NA +363150 NA False True NA +363465 NA True False Digestion +363644 NA True False NA +363875 Rac1 True True GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;NRAGE signals death through JNK;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;DAP12 signaling;FCERI mediated MAPK activation;DSCAM interactions;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Sema3A PAK dependent Axon repulsion;PCP/CE pathway;Sema4D mediated inhibition of cell attachment and migration;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;Signal transduction by L1;VEGFR2 mediated vascular permeability;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate NADPH Oxidases;MAPK6/MAPK4 signaling;Neutrophil degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;NTRK2 activates RAC1;Factors involved in megakaryocyte development and platelet production +363925 NA False True NA +363972 NA True False NA +364052 NA True False RAF-independent MAPK1/3 activation;RAF/MAP kinase cascade +364208 NA True False NA +364694 NA False True NA +364716 NA False True NA +364723 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +364838 NA True False Olfactory Signaling Pathway +365216 NA True False NA +365377 NA False True Smooth Muscle Contraction +365388 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation +365877 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +366189 NA False True NA +366448 NA False True NA +366568 NA True False NA +367171 NA True False NA +369016 NA True False NA +369017 NA False True NA +382522 NA False True NA +397785 NA False True NA +398985 NA False True NA +403728 NA False True NA +404093 NA False True NA +406167 NA True False NA +408248 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +432508 NA False True NA +445442 NA False True NA +450225 NA False True Keratinization;Formation of the cornified envelope +493810 NA True False MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Advanced glycosylation endproduct receptor signaling;Factors involved in megakaryocyte development and platelet production +494445 NA True False Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing +497198 NA True False NA +497794 NA True False NA +497902 NA True False NA +498174 NA False True NA +498407 NA True False NA +498433 NA False True UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +498736 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins +498909 NA True False NA +499417 Sumo3 False True SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription cofactors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of DNA replication proteins;SUMOylation of immune response proteins;Formation of Incision Complex in GG-NER +499529 NA True False Respiratory electron transport;Complex I biogenesis +499558 March11 False True NA +499782 NA True False NA +499913 NA True False Arachidonate production from DAG +500105 Cntnap2 False True NA +500282 NA True False NA +500351 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +500377 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins +500419 NA False True NA +500450 NA False True Striated Muscle Contraction;Smooth Muscle Contraction +500929 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins +500985 Cbl False True Interleukin-6 signaling;Spry regulation of FGF signaling;Regulation of KIT signaling;EGFR downregulation;TGF-beta receptor signaling activates SMADs;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Negative regulation of MET activity;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Regulation of signaling by CBL +501083 NA True False NA +501621 NA False True Transport of Mature mRNA derived from an Intron-Containing Transcript +501625 NA False True NA +502125 NA True False NA +502674 NA True False NA +502776 NA True False NA +502913 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +513971 NA False True NA +613226 NA True False NA +617095 NA False True NA +618164 NA False True NA +619561 NA False True Mitochondrial Fatty Acid Beta-Oxidation +641434 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation +678759 NA True False Respiratory electron transport;Complex I biogenesis +679221 NA True False NA +680102 NA False True NA +680423 NA False True NA +680522 NA False True NA +681896 NA True False Organic anion transporters +682507 Wasl False True Regulation of actin dynamics for phagocytic cup formation;NOSTRIN mediated eNOS trafficking;Nephrin family interactions;EPHB-mediated forward signaling;DCC mediated attractive signaling;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis +683313 NA False True NA +683788 NA True False NA +684097 NA True False NA +684988 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +685859 NA False True NA +686098 Sorbs1 False True NA +687008 NA True False NA +687090 NA True False NA +687506 NA False True NA +688288 NA True False Cleavage of Growing Transcript in the Termination Region ;ISG15 antiviral mechanism;Transport of Mature mRNA derived from an Intron-Containing Transcript;Deadenylation of mRNA;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +688386 NA True False NA +689064 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation +689560 Ryr2 True True NA +689852 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +690131 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +690163 NA True False Utilization of Ketone Bodies +690244 NA False True NA +690441 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation +690660 NA True False NA +690795 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +690987 NA False True Glycogen synthesis +691149 NA True False NA +691974 NA False True NA +824261 NA False True NA +852088 NA False True NA +852107 NA False True NA +853358 NA False True NA +100134871 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation +100145871 NA True False Ethanol oxidation +100359951 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +100359982 NA True False NA +100360117 NA True False NA +100360180 NA True False NA +100360501 NA True False NA +100360508 NA True False NA +100360679 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +100360846 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation +100360977 NA True False NA +100361558 NA True False PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production +100361891 NA True False NA +100361915 NA False True NA +100362149 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +100362640 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +100362684 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +100362830 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +100363439 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +100363502 NA True False NA +100364335 NA True False NA +100365810 NA True False NA +100909441 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins +100909595 NA True False Cellular hexose transport;Vitamin C (ascorbate) metabolism;Neutrophil degranulation +100909840 NA True False Signaling by ROBO receptors;RHO GTPases Activate Formins +100911186 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA +100911372 NA True False NA +100911402 NA True False NA +100911417 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation +100911625 NA True False Gluconeogenesis +100912489 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +100912564 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +102555453 NA True False NA +103689947 NA True False NA +103689983 NA True False Purine salvage +103689992 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +103689999 NA True False Platelet degranulation +103690002 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression +103690190 NA True False NA +103692716 NA True False Signaling by ERBB2;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression +103693564 NA True False NA +103693780 NA True False Glyoxylate metabolism and glycine degradation;Lysine catabolism +103694857 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation +103694877 NA True False Cell surface interactions at the vascular wall;Neutrophil degranulation +103694903 NA True False Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;CTLA4 inhibitory signaling;RHO GTPases Activate Formins;RAF activation;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +108348061 NA True False NA +108348073 NA True False Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit +108348108 NA True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation +108348115 NA True False NA +108348142 NA True False NA +108348148 NA True False Glutathione conjugation +108348161 NA True False NA +108351137 NA True False NA +NA NA True False NA