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view test-data/Nodes_bioplex_from_Lacombe_geneID.tsv @ 2:99f6a94c1ade draft
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| author | proteore |
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| date | Fri, 28 Jun 2019 05:06:57 -0400 |
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UniProt-AC Present in user input ids ID present in Human Bioplex Pathway A8K2U0 True False NA E7EP37 False True NA O43707 True False Platelet degranulation ;Nephrin family interactions O60911 True True Endosomal/Vacuolar pathway;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes O75223 True False Glutathione synthesis and recycling O75342 True False Synthesis of 12-eicosatetraenoic acid derivatives O75369 True False ISG15 antiviral mechanism O75635 True False NA O95274 True False Post-translational modification: synthesis of GPI-anchored proteins P00338 True True Pyruvate metabolism P00441 True True Platelet degranulation ;Detoxification of Reactive Oxygen Species;Detoxification of Reactive Oxygen Species;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation P00491 True False Neutrophil degranulation;Purine salvage;Purine catabolism P00558 True False Glycolysis;Gluconeogenesis P00738 True False Scavenging of heme from plasma;Neutrophil degranulation P01009 True False Platelet degranulation ;COPII-mediated vesicle transport;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Neutrophil degranulation;Post-translational protein phosphorylation P01011 True False Platelet degranulation ;Neutrophil degranulation P01036 True False NA P01037 True True NA P01040 True False Formation of the cornified envelope P01213 False True Opioid Signalling;G-protein activation;Peptide ligand-binding receptors;G alpha (i) signalling events P01623 True False NA P01625 True False NA P01765 True False NA P01766 True False Initial triggering of complement;Classical antibody-mediated complement activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;FCGR activation;FCGR activation;Regulation of actin dynamics for phagocytic cup formation;Role of phospholipids in phagocytosis;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;CD22 mediated BCR regulation;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers P01833 True False Neutrophil degranulation P01834 True False Initial triggering of complement;Classical antibody-mediated complement activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;FCGR activation;FCGR activation;Regulation of actin dynamics for phagocytic cup formation;Role of phospholipids in phagocytosis;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;CD22 mediated BCR regulation;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers P01857 True False Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;FCGR activation;Regulation of actin dynamics for phagocytic cup formation;Role of phospholipids in phagocytosis;Interleukin-4 and Interleukin-13 signaling;Regulation of Complement cascade P01860 True False Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;FCGR activation;Regulation of actin dynamics for phagocytic cup formation;Role of phospholipids in phagocytosis;Regulation of Complement cascade P01871 True False Cell surface interactions at the vascular wall;CD22 mediated BCR regulation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers P01876 True False Cell surface interactions at the vascular wall;Scavenging of heme from plasma P01877 True False Cell surface interactions at the vascular wall;Scavenging of heme from plasma P02538 True False Keratinization;Formation of the cornified envelope P02545 True False XBP1(S) activates chaperone genes;Signaling by BRAF and RAF fusions P02763 True True Platelet degranulation ;Neutrophil degranulation P02768 True False Platelet degranulation ;Recycling of bile acids and salts;Scavenging of heme from plasma;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR);Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR);Transport of organic anions;Post-translational protein phosphorylation;HDL remodeling P02787 True False Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation;Iron uptake and transport;Transferrin endocytosis and recycling P02788 True False Mtb iron assimilation by chelation;Neutrophil degranulation;Metal sequestration by antimicrobial proteins;Antimicrobial peptides;Amyloid fiber formation P04040 True False Detoxification of Reactive Oxygen Species;Neutrophil degranulation;Peroxisomal protein import;Peroxisomal protein import;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes P04075 True True Platelet degranulation ;Neutrophil degranulation;Glycolysis;Gluconeogenesis P04080 True False Neutrophil degranulation P04083 True False G alpha (q) signalling events;G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Smooth Muscle Contraction;Interleukin-4 and Interleukin-13 signaling P04259 True False Keratinization;Formation of the cornified envelope P04264 True False Neutrophil degranulation;Keratinization;Formation of the cornified envelope P04406 True True Glycolysis;Gluconeogenesis P04745 True False Digestion of dietary carbohydrate P04792 True False VEGFA-VEGFR2 Pathway;AUF1 (hnRNP D0) binds and destabilizes mRNA;MAPK6/MAPK4 signaling P05089 True False Neutrophil degranulation;Urea cycle P05090 True True Transport of fatty acids P06396 True False Caspase-mediated cleavage of cytoskeletal proteins;Neutrophil degranulation;Amyloid fiber formation P06733 True False Glycolysis;Gluconeogenesis P06870 True False Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) P07339 True False Collagen degradation;Metabolism of Angiotensinogen to Angiotensins;MHC class II antigen presentation;Neutrophil degranulation;Estrogen-dependent gene expression P07355 True False Smooth Muscle Contraction;Neutrophil degranulation;Dissolution of Fibrin Clot;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation P07384 True True Degradation of the extracellular matrix;Degradation of the extracellular matrix;Neutrophil degranulation;Formation of the cornified envelope;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models P07711 False True Endosomal/Vacuolar pathway;Collagen degradation;Degradation of the extracellular matrix;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes P07858 True False Collagen degradation;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;Neutrophil degranulation P07864 False True Pyruvate metabolism P07900 True False Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;vRNP Assembly;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;Scavenging by Class F Receptors;Scavenging by Class F Receptors;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Uptake and function of diphtheria toxin;PIWI-interacting RNA (piRNA) biogenesis;Anchoring of the basal body to the plasma membrane;Constitutive Signaling by EGFRvIII;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression P08779 True False Keratinization;Formation of the cornified envelope P08865 True True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) P09211 True False Glutathione conjugation;Detoxification of Reactive Oxygen Species;Neutrophil degranulation P09228 True False NA P09668 False True MHC class II antigen presentation;Surfactant metabolism;Neutrophil degranulation P09972 True True Neutrophil degranulation;Glycolysis;Gluconeogenesis P0CG05 True False NA P0DMV9 True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;Neutrophil degranulation P10599 True False Oxidative Stress Induced Senescence;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;TP53 Regulates Metabolic Genes;Protein repair;The NLRP3 inflammasome;The NLRP3 inflammasome;Regulation of FOXO transcriptional activity by acetylation P11021 True False Platelet degranulation ;Regulation of HSF1-mediated heat shock response;ATF6 (ATF6-alpha) activates chaperones;PERK regulates gene expression;IRE1alpha activates chaperones;ATF6 (ATF6-alpha) activates chaperone genes;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC P11142 True True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;CHL1 interactions;AUF1 (hnRNP D0) binds and destabilizes mRNA;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;mRNA Splicing - Major Pathway;Clathrin-mediated endocytosis;Protein methylation;GABA synthesis, release, reuptake and degradation P11279 True True Neutrophil degranulation P12273 True False Miscellaneous transport and binding events P13473 True False Platelet degranulation ;Neutrophil degranulation P13639 True False Peptide chain elongation;Peptide chain elongation;Uptake and function of diphtheria toxin;Synthesis of diphthamide-EEF2;Synthesis of diphthamide-EEF2;Neutrophil degranulation;Protein methylation P13645 True False Keratinization;Formation of the cornified envelope P13646 True False Keratinization;Formation of the cornified envelope P14618 True False Neutrophil degranulation P14735 True False Ub-specific processing proteases;Peroxisomal protein import;Peroxisomal protein import P14923 True False Adherens junctions interactions;VEGFR2 mediated vascular permeability;Neutrophil degranulation;Keratinization;Formation of the cornified envelope P15924 True False Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope P18206 True False Platelet degranulation ;Smooth Muscle Contraction;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF P18510 True False Interleukin-10 signaling;Interleukin-1 signaling P19012 True False Keratinization;Formation of the cornified envelope P19013 True False Keratinization;Formation of the cornified envelope P19823 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation P19971 True False Pyrimidine salvage;Pyrimidine catabolism P20930 True False Formation of the cornified envelope P20933 True True Neutrophil degranulation P22528 True False Formation of the cornified envelope P22531 True False Formation of the cornified envelope P23284 True False Collagen biosynthesis and modifying enzymes P23396 True False L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) P25311 True False Miscellaneous transport and binding events P25705 True False Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Cristae formation P25788 True False Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation P26641 True True Eukaryotic Translation Elongation P27482 True False NA P29508 True True Neutrophil degranulation P30740 True False Neutrophil degranulation P31025 True True Transport of fatty acids P31151 True False Neutrophil degranulation;Metal sequestration by antimicrobial proteins P31944 True False Formation of the cornified envelope P31947 True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors P31949 True False Neutrophil degranulation P35579 True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs P35908 True False Keratinization;Formation of the cornified envelope P36952 True True NA P40121 True True NA P40926 True False Gluconeogenesis;Citric acid cycle (TCA cycle) P41222 False True Synthesis of Prostaglandins (PG) and Thromboxanes (TX) P42357 True True Histidine catabolism P47756 True False MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production P47929 True False NA P48594 True True NA P48637 True False Glutathione synthesis and recycling;Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) P49720 True True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation P50395 True True Rho GTPase cycle;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs P58107 True False NA P59666 True False Defensins;Alpha-defensins P59998 True False Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis P60174 True False Glycolysis;Gluconeogenesis P60842 True True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit P61160 True False Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis P61626 True False Neutrophil degranulation;Antimicrobial peptides;Amyloid fiber formation P61916 True True Neutrophil degranulation;LDL clearance P62258 True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Signaling by Hippo;NADE modulates death signalling;Regulation of PLK1 Activity at G2/M Transition;Regulation of HSF1-mediated heat shock response;HSF1 activation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;RAB GEFs exchange GTP for GDP on RABs P62937 True False Platelet degranulation ;Uncoating of the HIV Virion;Budding and maturation of HIV virion;Integration of provirus;Early Phase of HIV Life Cycle;Minus-strand DNA synthesis;Plus-strand DNA synthesis;Binding and entry of HIV virion;Assembly Of The HIV Virion;APOBEC3G mediated resistance to HIV-1 infection;Calcineurin activates NFAT;Basigin interactions;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation P62987 True False Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Viral mRNA Translation;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Selenocysteine synthesis;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Major pathway of rRNA processing in the nucleolus and cytosol;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation P63104 True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Deactivation of the beta-catenin transactivating complex;Rap1 signalling;GP1b-IX-V activation signalling;KSRP (KHSRP) binds and destabilizes mRNA;Interleukin-3, Interleukin-5 and GM-CSF signaling;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;NOTCH4 Activation and Transmission of Signal to the Nucleus;Negative regulation of NOTCH4 signaling;Regulation of localization of FOXO transcription factors P63261 True False Translocation of SLC2A4 (GLUT4) to the plasma membrane;Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;Adherens junctions interactions;Adherens junctions interactions;Recycling pathway of L1;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Clathrin-mediated endocytosis P68363 True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins P68371 True False Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins P68871 True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation;Factors involved in megakaryocyte development and platelet production P78386 True False Keratinization;Formation of the cornified envelope P80188 True False Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;Metal sequestration by antimicrobial proteins;Iron uptake and transport;Iron uptake and transport P81605 True False Antimicrobial peptides Q01469 True False Triglyceride catabolism;Signaling by Retinoic Acid;Neutrophil degranulation Q02413 True False Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope Q04695 True False Keratinization;Formation of the cornified envelope Q06830 True False Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Q08188 True True NA Q13867 True True Antigen processing: Ubiquitination & Proteasome degradation Q13951-2 False True NA Q14574 True False Keratinization;Formation of the cornified envelope Q15149 True False Assembly of collagen fibrils and other multimeric structures;Caspase-mediated cleavage of cytoskeletal proteins;Type I hemidesmosome assembly Q15828 True False NA Q5D862 True False Neutrophil degranulation Q5T749 True False NA Q5T750 True False NA Q5VWX1 False True PTK6 Regulates Proteins Involved in RNA Processing Q6KB66 True False Keratinization;Formation of the cornified envelope Q6P4A8 True False Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC Q6UWP8 True False NA Q6UXD5-2 False True NA Q7Z434 False True DDX58/IFIH1-mediated induction of interferon-alpha/beta;Ovarian tumor domain proteases;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Negative regulators of DDX58/IFIH1 signaling;Negative regulators of DDX58/IFIH1 signaling Q7Z7L7 False True NA Q86X55-1 False True NA Q86YZ3 True False Neutrophil degranulation Q8IW75 True True NA Q8N1N4 True False Keratinization;Formation of the cornified envelope Q8N5L8 False True NA Q8N6R0-1 False True NA Q8NB91 False True Fanconi Anemia Pathway Q8TA86 False True NA Q8TAX7 True False Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis Q8WVV4 True False NA Q8WZA9 False True NA Q92692-2 False True NA Q92820 True True Neutrophil degranulation Q96DA0 True True NA Q96FX8 True False TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Formation of the cornified envelope Q96P63 True False Neutrophil degranulation Q96SI1 False True Negative regulation of activity of TFAP2 (AP-2) family transcription factors Q9BPX6-2 False True NA Q9BQG2 False True Nicotinamide salvaging Q9BU70 False True NA Q9BZE9-2 False True NA Q9C075 True False Keratinization;Formation of the cornified envelope Q9H4Z2-2 False True NA Q9H8K7 False True NA Q9HB20 False True Synthesis of PIPs at the plasma membrane Q9HC84 True False Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis Q9HCY8 True False NA Q9NPJ1 False True BBSome-mediated cargo-targeting to cilium Q9NSI2-2 False True NA Q9NZH8 True False Interleukin-36 pathway Q9NZT1 True False Neutrophil degranulation Q9UGM3 True False Surfactant metabolism Q9UI42 True False NA Q9UIV8 True False RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Q9Y371-2 False True NA Q9Y570 False True Cyclin A/B1/B2 associated events during G2/M transition Q9Y6R7 True False NA