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view test-data/Nodes_biogrid_from_Rattus_Hameza_dataset_geneID.tsv @ 5:ba96ca3496a2 draft default tip
"planemo upload commit c9a32e920aae2bc186183611bc0abb2040e106f3"
| author | proteore |
|---|---|
| date | Thu, 06 Feb 2020 08:28:04 -0500 |
| parents | 99f6a94c1ade |
| children |
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Entrez gene ID Official Symbol Interactor Present in user input ids ID present in Biogrid Rat Pathway 25 ABL1 False True NA 81 ACTN4 False True NA 142 PARP1 False True NA 156 NA False True NA 160 AP2A1 False True NA 176 NA False True NA 207 AKT1 False True NA 273 AMPH False True NA 310 NA False True NA 366 NA False True NA 627 NA False True NA 640 NA False True NA 657 NA False True NA 658 NA False True NA 661 NA False True NA 673 NA False True NA 695 NA False True NA 815 CAMK2A False True NA 818 NA False True NA 857 NA False True NA 921 NA False True NA 1020 NA False True NA 1048 CEACAM5 False True NA 1147 CHUK False True NA 1326 NA False True NA 1457 NA False True NA 1742 DLG4 False True NA 1759 DNM1 False True NA 1956 NA False True NA 1969 NA False True NA 1978 NA False True NA 1983 NA False True NA 2054 STX2 False True NA 2060 EPS15 False True NA 2257 NA False True NA 2287 NA False True NA 2321 NA False True NA 2534 NA False True NA 2569 NA False True NA 2997 NA False True NA 3005 NA False True NA 3053 NA False True NA 3091 HIF1A False True NA 3337 DNAJB1 False True NA 3551 IKBKB False True NA 3897 L1CAM False True NA 4133 NA False True NA 4137 MAPT False True NA 4155 NA False True NA 4215 NA False True NA 4430 NA False True NA 4690 NA False True NA 4692 NA False True NA 4792 NA False True NA 4908 NTF3 False True NA 4915 NA False True NA 5156 NA False True NA 5340 NA False True NA 5414 NA False True NA 5467 NA False True NA 5481 NA False True NA 5518 NA False True NA 5580 NA False True NA 5604 NA False True NA 5638 NA False True NA 5829 NA False True NA 5998 NA False True NA 6300 NA False True NA 6330 NA False True NA 6449 NA False True NA 6477 SIAH1 False True NA 6622 SNCA False True NA 6721 NA False True NA 6769 NA False True NA 6804 STX1A False True NA 6809 STX3 False True NA 6810 STX4 False True NA 6857 NA False True NA 6885 NA False True NA 7006 NA False True NA 7041 TGFB1I1 False True NA 7157 TP53 False True NA 7265 NA False True NA 7266 NA False True NA 7528 NA False True NA 7704 ZBTB16 False True NA 7867 NA False True NA 7874 NA False True NA 7881 NA False True NA 8416 NA False True NA 8514 NA False True NA 8550 NA False True NA 8573 NA False True NA 8576 NA False True NA 8894 EIF2S2 False True NA 9014 NA False True NA 9040 NA False True NA 9379 NA False True NA 9454 HOMER3 False True NA 9495 AKAP5 False True NA 9616 NA False True NA 9962 NA False True NA 10000 NA False True NA 10013 HDAC6 False True NA 10018 BCL2L11 False True NA 10110 NA False True NA 10116 NA False True NA 10152 NA False True NA 10243 NA False True NA 10278 NA False True NA 10572 NA False True NA 10963 NA False True NA 11651 NA False True NA 11674 NA False True NA 11740 NA False True NA 11747 NA False True NA 11758 NA False True NA 11792 NA False True NA 11842 NA False True NA 11843 NA False True NA 11946 NA False True NA 11950 NA False True NA 12034 Phb2 False True NA 12043 NA False True NA 12346 NA False True NA 12349 NA False True NA 12416 NA False True NA 12461 NA False True NA 12468 NA False True NA 12540 NA False True NA 12631 NA False True NA 12995 NA False True NA 13211 NA False True NA 13628 Eef1a2 False True NA 13644 Efs False True NA 13665 NA False True NA 13682 NA False True NA 14182 Fgfr1 False True NA 14265 NA False True NA 14400 NA False True NA 14406 NA False True NA 14751 NA False True NA 14811 NA False True NA 14812 NA False True NA 14813 NA False True NA 15288 NA False True NA 15289 NA False True NA 15354 NA False True NA 15381 NA False True NA 15382 NA False True NA 15384 NA False True NA 15387 NA False True NA 15441 NA False True NA 15526 NA False True NA 15568 NA False True NA 16211 Kpnb1 False True NA 16647 Kpna2 False True NA 16649 Kpna4 False True NA 16906 NA False True NA 17089 NA False True NA 17192 NA False True NA 17220 NA False True NA 17448 NA False True NA 17920 NA False True NA 17938 NA False True NA 17999 Nedd4 False True NA 18102 NA False True NA 18148 NA False True NA 18150 NA False True NA 18477 NA False True NA 18521 NA False True NA 18648 NA False True NA 18674 NA False True NA 18795 NA False True NA 19016 Pparg False True NA 19045 NA False True NA 19360 NA False True NA 19384 NA False True NA 19387 NA False True NA 19655 NA False True NA 19942 NA False True NA 19944 NA False True NA 19946 NA False True NA 19951 NA False True NA 20005 NA False True NA 20024 NA False True NA 20054 NA False True NA 20068 NA False True NA 20088 NA False True NA 20133 NA False True NA 20191 NA False True NA 20382 NA False True NA 20383 Srsf3 False True NA 20586 NA False True NA 20614 Snap25 False True NA 20641 NA False True NA 20740 NA False True NA 20823 NA False True NA 20832 NA False True NA 21672 NA False True NA 21894 NA False True NA 21917 NA False True NA 21937 NA False True NA 21991 NA False True NA 22070 NA False True NA 22129 Ttc3 False True NA 22273 NA False True NA 22334 NA False True NA 22335 NA False True NA 22608 NA False True NA 22791 NA False True NA 22849 CPEB3 False True NA 22888 NA False True NA 23024 NA False True NA 23558 NA False True NA 23983 NA False True NA 24061 NA False True NA 24158 NA False True Beta oxidation of octanoyl-CoA to hexanoyl-CoA 24159 NA True False ChREBP activates metabolic gene expression;Neutrophil degranulation;Fatty acyl-CoA biosynthesis 24161 NA True False NA 24170 NA True False NA 24171 NA True False Miscellaneous transport and binding events 24183 NA True False NA 24185 Akt1 False True PIP3 activates AKT signaling;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;mTOR signalling;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the nucleus;Negative regulation of the PI3K/AKT network;eNOS activation;Integrin alphaIIb beta3 signaling;Deactivation of the beta-catenin transactivating complex;CD28 dependent PI3K/Akt signaling;CTLA4 inhibitory signaling;G beta:gamma signalling through PI3Kgamma;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;VEGFR2 mediated vascular permeability;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 24186 NA True False Platelet degranulation ;Recycling of bile acids and salts;Scavenging of heme from plasma;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Transport of organic anions;Post-translational protein phosphorylation;HDL remodeling 24189 NA True False Platelet degranulation ;Neutrophil degranulation;Gluconeogenesis 24191 NA True False Neutrophil degranulation;Gluconeogenesis 24192 NA True False Pregnenolone biosynthesis 24205 Apc False True Apoptotic cleavage of cellular proteins;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;Deactivation of the beta-catenin transactivating complex;Ovarian tumor domain proteases 24211 Atp1a1 True True Ion homeostasis;Ion transport by P-type ATPases 24212 Atp1a2 True True Ion homeostasis;Ion transport by P-type ATPases 24213 Atp1a3 True True Ion homeostasis;Ion transport by P-type ATPases 24215 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases 24223 B2m False True ER-Phagosome pathway;Endosomal/Vacuolar pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 interactions;DAP12 signaling;Neutrophil degranulation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 24232 NA True False Alternative complement activation;Activation of C3 and C5;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (i) signalling events;Neutrophil degranulation;Post-translational protein phosphorylation;Regulation of Complement cascade 24233 NA False True NA 24242 Calm1 True True CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;Platelet degranulation ;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;eNOS activation;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;VEGFR2 mediated vascular permeability;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Glycogen breakdown (glycogenolysis);Protein methylation;Ion transport by P-type ATPases;Activation of RAC1 downstream of NMDARs;Long-term potentiation 24244 NA True False CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;Platelet degranulation ;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;eNOS activation;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;VEGFR2 mediated vascular permeability;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Glycogen breakdown (glycogenolysis);Protein methylation;Ion transport by P-type ATPases;Activation of RAC1 downstream of NMDARs;Long-term potentiation 24245 Camk2b True True HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Interferon gamma signaling;Ion transport by P-type ATPases 24248 NA False True Detoxification of Reactive Oxygen Species;Neutrophil degranulation;Peroxisomal protein import 24250 NA True False Cysteine formation from homocysteine 24264 NA True False Creatine metabolism 24265 NA False True Creatine metabolism 24316 Drd1 False True Dopamine receptors;G alpha (s) signalling events 24329 Egfr False True NA 24333 NA True False Gluconeogenesis 24334 NA True False Gluconeogenesis 24367 NA True False Platelet degranulation ;Common Pathway of Fibrin Clot Formation;Integrin cell surface interactions;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAP2K and MAPK activation;Post-translational protein phosphorylation 24368 NA True False Citric acid cycle (TCA cycle) 24377 NA True False TP53 Regulates Metabolic Genes;Pentose phosphate pathway 24380 NA True False GABA synthesis;GABA synthesis, release, reuptake and degradation 24383 Gapdh True True NA 24387 NA True False NA 24392 Gja1 True True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;Gap junction degradation;c-src mediated regulation of Cx43 function and closure of gap junctions;Formation of annular gap junctions;Transport of connexins along the secretory pathway 24398 Gls True True NA 24399 NA True False Transcriptional activation of mitochondrial biogenesis;Amino acid synthesis and interconversion (transamination) 24400 Gnb1 True True Activation of G protein gated Potassium channels;G-protein activation;Activation of the phototransduction cascade;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Olfactory Signaling Pathway;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 24401 NA True False Amino acid synthesis and interconversion (transamination) 24408 Grin1 True True EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade;Synaptic adhesion-like molecules 24409 Grin2a True True NA 24410 Grin2b True True EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade;Synaptic adhesion-like molecules 24414 Grm1 False True G alpha (q) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);Neurexins and neuroligins 24416 Grm3 True True G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors) 24417 Grm4 False True NA 24418 Grm5 True True NA 24421 NA True False NA 24423 Gstm1 True True NA 24424 NA False True Glutathione conjugation 24426 NA True False Glutathione conjugation;Detoxification of Reactive Oxygen Species;Neutrophil degranulation 24437 NA True False NA 24439 NA True False Pyruvate metabolism 24440 NA True False NA 24465 NA True False Purine salvage 24468 Hspa8 True True NA 24472 NA True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation 24479 NA True False NADPH regeneration;Neutrophil degranulation;Peroxisomal protein import 24511 Itgb1 False True Elastic fibre formation;Fibronectin matrix formation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;Basigin interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Laminin interactions;Syndecan interactions;ECM proteoglycans;Signal transduction by L1;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;MET activates PTK2 signaling;MET interacts with TNS proteins 24513 NA True False Branched-chain amino acid catabolism 24525 Kras True True Activation of RAS in B cells;SHC1 events in ERBB4 signaling;Signaling by SCF-KIT;p38MAPK events;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;Downstream signal transduction;GRB2 events in ERBB2 signaling;Tie2 Signaling;EGFR Transactivation by Gastrin;DAP12 signaling;FCERI mediated MAPK activation;NCAM signaling for neurite out-growth;VEGFR2 mediated cell proliferation;CD209 (DC-SIGN) signaling;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Regulation of RAS by GAPs;RAF activation;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative regulation of MAPK pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAS signaling;RUNX3 regulates p14-ARF 24533 NA True False Pyruvate metabolism 24534 NA True False Pyruvate metabolism 24547 NA True False NA 24551 NA True False Gluconeogenesis 24585 NA False True Striated Muscle Contraction 24586 Ncam1 True True NA 24588 NA True False NA 24592 Nf1 True True NA 24596 Ngfr False True Axonal growth inhibition (RHOA activation);Regulated proteolysis of p75NTR;NFG and proNGF binds to p75NTR;NADE modulates death signalling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Axonal growth stimulation 24598 Nos1 False True ROS, RNS production in phagocytes;Nitric oxide stimulates guanylate cyclase;Ion homeostasis 24642 NA True False Neutrophil degranulation;Gluconeogenesis 24644 NA True False Gluconeogenesis 24648 NA True False Platelet degranulation ;COPII-mediated vesicle transport;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Neutrophil degranulation;Post-translational protein phosphorylation 24653 NA False True phospho-PLA2 pathway;Acyl chain remodelling of PC;Acyl chain remodeling of CL;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC;Synthesis of PA;Arachidonic acid metabolism;ADP signalling through P2Y purinoceptor 1;Platelet sensitization by LDL;COPI-independent Golgi-to-ER retrograde traffic 24654 Plcb1 True True NA 24666 Ppm1a True True NA 24668 NA True False DARPP-32 events 24672 Ppp2ca True True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;CTLA4 inhibitory signaling;RHO GTPases Activate Formins;RAF activation;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 24674 Ppp3ca True True Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation 24675 Ppp3cb True True NA 24679 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;Hedgehog 'off' state;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2;Factors involved in megakaryocyte development and platelet production 24680 Prkca False True Calmodulin induced events;Disinhibition of SNARE formation;SHC1 events in ERBB2 signaling;Signaling by SCF-KIT;Regulation of KIT signaling;EGFR Transactivation by Gastrin;Syndecan interactions;Acetylcholine regulates insulin secretion;Depolymerisation of the Nuclear Lamina;HuR (ELAVL1) binds and stabilizes mRNA;WNT5A-dependent internalization of FZD4;VEGFR2 mediated cell proliferation;Response to elevated platelet cytosolic Ca2+;RET signaling;ROBO receptors bind AKAP5 24681 Prkcg True True Calmodulin induced events;Disinhibition of SNARE formation;WNT5A-dependent internalization of FZD4;Response to elevated platelet cytosolic Ca2+ 24686 Prnp True True NA 24688 NA False True NA 24691 NA False True Collagen degradation;Activation of Matrix Metalloproteinases;Cobalamin (Cbl, vitamin B12) transport and metabolism;Neutrophil degranulation;Antimicrobial peptides 24703 Raf1 False True Stimuli-sensing channels;Rap1 signalling;GP1b-IX-V activation signalling;CD209 (DC-SIGN) signaling;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway 24716 Ret True True RAF/MAP kinase cascade;RET signaling 24766 Scn2a True True NA 24767 Scnn1b False True Stimuli-sensing channels 24768 Scnn1g False True NA 24773 Sftpa1 False True Signal regulatory protein family interactions;Surfactant metabolism;Regulation of TLR by endogenous ligand 24778 Slc2a1 True True Cellular hexose transport;Vitamin C (ascorbate) metabolism;Regulation of insulin secretion;Lactose synthesis 24786 Sod1 True True Platelet degranulation ;Detoxification of Reactive Oxygen Species 24787 NA True False Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species 24799 NA True False NA 24803 Vamp2 True True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Clathrin derived vesicle budding;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Other interleukin signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;GABA synthesis, release, reuptake and degradation 24804 Syp True True NA 24818 NA True False Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 24825 NA True False Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation;Iron uptake and transport;Transferrin endocytosis and recycling 24826 Tg False True NA 24828 NA True False Metalloprotease DUBs 24832 NA True False Post-translational modification: synthesis of GPI-anchored proteins 24838 NA False True Striated Muscle Contraction 24849 NA True False Glycolysis 24851 NA True False NA 24854 NA True False Platelet degranulation ;Terminal pathway of complement;Antimicrobial peptides;Regulation of Complement cascade 24855 Tsc2 False True Macroautophagy;Inhibition of TSC complex formation by PKB;AKT phosphorylates targets in the cytosol;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;TBC/RABGAPs 24875 NA False True NA 24887 Bax False True Release of apoptotic factors from the mitochondria;Activation, translocation and oligomerization of BAX;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 24888 Bcl2l1 False True NA 24896 NA True False NA 24898 Slc6a3 False True Dopamine clearance from the synaptic cleft;Na+/Cl- dependent neurotransmitter transporters 24917 NA True False NA 24923 Stx1b True True LGI-ADAM interactions 24936 NA True False Platelet degranulation ;Sperm:Oocyte Membrane Binding 24943 NA True False NA 24949 NA True False Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle 24954 Insr False True PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;Insulin receptor signalling cascade;Signaling by Insulin receptor;Insulin receptor recycling 24957 NA True False Astrocytic Glutamate-Glutamine Uptake And Metabolism;Amino acid synthesis and interconversion (transamination) 24963 NA False True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation 25009 NA True False NA 25012 Snap25 True True NA 25014 NA True False Branched-chain amino acid catabolism 25017 NA True False NA 25023 Prkcb True True NA 25027 NA False True Basigin interactions;Proton-coupled monocarboxylate transport;Pyruvate metabolism 25035 NA True False Vitamin C (ascorbate) metabolism;Phase I - Functionalization of compounds;Neutrophil degranulation 25037 NA True False NA 25050 NA False True CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 25051 NA False True NA 25054 Ntrk2 True True Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through FRS2 and FRS3;NTRK2 activates RAC1 25058 NA True False NA 25059 Hk2 False True Glycolysis 25062 NA True False NA 25085 Th False True Catecholamine biosynthesis 25097 Pld2 False True NA 25101 NA False True Highly sodium permeable acetylcholine nicotinic receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly calcium permeable nicotinic acetylcholine receptors 25104 NA True False Biotin transport and metabolism;Gluconeogenesis 25122 Scnn1a False True Stimuli-sensing channels 25124 NA False True Interleukin-6 signaling;ISG15 antiviral mechanism;Signaling by SCF-KIT;Downstream signal transduction;Interleukin-4 and Interleukin-13 signaling;Interferon gamma signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-27 signaling;Interleukin-21 signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling 25130 Stx2 False True NA 25135 NA False True Major pathway of rRNA processing in the nucleolus and cytosol 25152 Map1a True True NA 25176 NA True False Regulation of insulin secretion 25177 NA False True NA 25181 NA False True A tetrasaccharide linker sequence is required for GAG synthesis;Chondroitin sulfate biosynthesis;Dermatan sulfate biosynthesis;CS/DS degradation;ECM proteoglycans 25183 NA True False Rho GTPase cycle;RAB GEFs exchange GTP for GDP on RABs 25218 NA False True Retrograde transport at the Trans-Golgi-Network 25230 NA True False Miscellaneous transport and binding events 25244 NA True False NA 25246 NA True False Degradation of the extracellular matrix;Basigin interactions;Integrin cell surface interactions;Proton-coupled monocarboxylate transport;Pyruvate metabolism 25248 Cnr1 True True Class A/1 (Rhodopsin-like receptors);G alpha (i) signalling events 25252 Dlg1 True True NA 25262 Itpr1 True True Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;cGMP effects;Ion homeostasis;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 25270 NA True False ABC transporters in lipid homeostasis 25272 NA True False Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors 25274 NA True False Degradation of cysteine and homocysteine 25275 Cnp True True NA 25282 NA True False NA 25287 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 25288 NA False True alpha-linolenic acid (ALA) metabolism;Synthesis of very long-chain fatty acyl-CoAs 25291 NA True False NA 25293 NA True False Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins 25303 Abcc2 False True ABC-family proteins mediated transport 25307 NA True False Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation 25309 NA True False NA 25316 Ms4a2 False True NA 25319 NA True False NA 25344 NA True False NA 25349 NA True False Phase 0 - rapid depolarisation 25353 Spp1 False True Degradation of the extracellular matrix;Signaling by PDGF;Integrin cell surface interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 25356 NA True False NA 25363 NA False True NA 25368 NA True False Purine salvage 25379 NA True False NA 25380 NA False True G alpha (q) signalling events;G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands 25388 Arrb2 False True G alpha (s) signalling events;Thrombin signalling through proteinase activated receptors (PARs);WNT5A-dependent internalization of FZD4;Activation of SMO;MAP2K and MAPK activation;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 25390 NA False True Basigin interactions;Ion homeostasis;Ion transport by P-type ATPases 25393 NA True False Degradation of the extracellular matrix;A tetrasaccharide linker sequence is required for GAG synthesis;Chondroitin sulfate biosynthesis;Dermatan sulfate biosynthesis;CS/DS degradation;ECM proteoglycans 25398 Cacna1a False True NA 25399 NA False True NA 25400 Camk2a True True NA 25413 NA False True NA 25414 Bcar1 False True NA 25415 NA True False CRMPs in Sema3A signaling 25416 Dpysl2 True True CRMPs in Sema3A signaling;Recycling pathway of L1 25417 NA True False CRMPs in Sema3A signaling 25418 NA True False CRMPs in Sema3A signaling 25420 NA True False HSF1-dependent transactivation 25434 NA True False NA 25438 NA False True Gluconeogenesis 25448 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase 25450 NA True False GABA A receptor activation 25456 Glrb False True Neurotransmitter receptors and postsynaptic signal transmission 25459 NA True False NA 25466 NA False True PIP3 activates AKT signaling;Receptor-type tyrosine-protein phosphatases;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-36 pathway;Interleukin-33 signaling;Interleukin-1 signaling 25467 Irs1 False True NA 25468 Kcna2 True True Voltage gated Potassium channels 25470 Kcna5 False True Voltage gated Potassium channels 25473 NA True False Laminin interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MET activates PTK2 signaling;Post-translational protein phosphorylation 25485 NA True False NA 25489 Nedd4 True True ISG15 antiviral mechanism;Downregulation of ERBB4 signaling;Regulation of PTEN localization;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation 25498 NA False True NA 25506 P4hb True True Collagen biosynthesis and modifying enzymes;Detoxification of Reactive Oxygen Species;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Hedgehog ligand biogenesis;Post-translational protein phosphorylation;Chylomicron assembly;Interleukin-12 signaling 25513 Pik3r1 False True PI3K Cascade;IRS-mediated signalling;GPVI-mediated activation cascade;PI3K events in ERBB4 signaling;PIP3 activates AKT signaling;Interleukin-7 signaling;Signaling by SCF-KIT;Synthesis of PIPs at the plasma membrane;GAB1 signalosome;Downstream signal transduction;PI3K events in ERBB2 signaling;PI3K/AKT activation;Downstream TCR signaling;Role of phospholipids in phagocytosis;Tie2 Signaling;DAP12 signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Costimulation by the CD28 family;CD28 dependent PI3K/Akt signaling;G alpha (q) signalling events;GP1b-IX-V activation signalling;VEGFA-VEGFR2 Pathway;Interleukin-3, Interleukin-5 and GM-CSF signaling;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates PI3K/AKT signaling;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Interleukin receptor SHC signaling;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 25518 NA True False NA 25522 Prkcz False True TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);VEGFR2 mediated cell proliferation 25528 NA True False Cell surface interactions at the vascular wall;DAP12 interactions;Signal regulatory protein family interactions;Neutrophil degranulation 25529 NA True False NA 25531 NA True False Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs;GABA synthesis, release, reuptake and degradation 25537 NA True False EPHB-mediated forward signaling;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases Activate ROCKs 25538 NA False True L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 25551 NA True False Cellular hexose transport;Vitamin C (ascorbate) metabolism;Neutrophil degranulation 25558 Stxbp1 True True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation 25562 Tceb3 False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation 25567 Tnr True True NA 25573 Ube2i False True SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Formation of Incision Complex in GG-NER;Negative regulation of activity of TFAP2 (AP-2) family transcription factors 25576 Ywhah True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 25577 NA True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors 25578 Ywhaz True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Deactivation of the beta-catenin transactivating complex;Rap1 signalling;GP1b-IX-V activation signalling;KSRP (KHSRP) binds and destabilizes mRNA;Interleukin-3, Interleukin-5 and GM-CSF signaling;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;NOTCH4 Activation and Transmission of Signal to the Nucleus;Regulation of localization of FOXO transcription factors 25581 Psmc2 True True NA 25594 NA True False Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate PAKs 25595 NA True False NA 25596 NA False True NA 25603 NA False True Acetylcholine regulates insulin secretion 25604 NA True False NA 25613 Ptprz1 True True Other interleukin signaling 25617 Hspa5 True True Regulation of HSF1-mediated heat shock response;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25622 Ptpn11 True True Interleukin-6 signaling;PI3K Cascade;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;GAB1 signalosome;Downstream signal transduction;Tie2 Signaling;Costimulation by the CD28 family;CTLA4 inhibitory signaling;PD-1 signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;FRS-mediated FGFR2 signaling;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;Interleukin-20 family signaling;MET activates PTPN11;Regulation of RUNX1 Expression and Activity;Interferon alpha/beta signaling;Regulation of IFNA signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 25630 NA True False Neutrophil degranulation;Glycolysis 25632 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma 25636 Prkaca False True PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;Regulation of insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;VEGFA-VEGFR2 Pathway;CREB1 phosphorylation through the activation of Adenylate Cyclase;Interleukin-3, Interleukin-5 and GM-CSF signaling;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'off' state;Anchoring of the basal body to the plasma membrane;CD209 (DC-SIGN) signaling;MAPK6/MAPK4 signaling;AURKA Activation by TPX2;HDL assembly;Factors involved in megakaryocyte development and platelet production 25639 NA True False TGF-beta receptor signaling activates SMADs 25650 NA True False Basigin interactions;Ion homeostasis;Ion transport by P-type ATPases 25663 NA False True Interleukin-1 signaling 25669 NA True False NA 25671 NA False True NA 25673 NA True False Platelet degranulation 25686 NA True False PLC beta mediated events;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 25697 NA False True Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 25716 NA True False Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;GABA synthesis, release, reuptake and degradation 25721 NA True False Glyoxylate metabolism and glycine degradation;Amino acid synthesis and interconversion (transamination) 25722 Scn4a False True Phase 0 - rapid depolarisation 25725 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;Hedgehog 'off' state;Factors involved in megakaryocyte development and platelet production 25728 NA True False Scavenging by Class A Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Chylomicron clearance;HDL remodeling;Retinoid metabolism and transport 25736 Kcnb1 False True Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 25738 Plcg1 False True NA 25739 NA True False NA 25740 NA True False PLC beta mediated events;G-protein activation;G alpha (z) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 25741 NA True False Neutrophil degranulation;Glycolysis 25742 S100b True True TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Advanced glycosylation endproduct receptor signaling;TRAF6 mediated NF-kB activation 25750 NA True False Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 25751 Dnm2 True True Gap junction degradation;Formation of annular gap junctions;NOSTRIN mediated eNOS trafficking;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Clathrin-mediated endocytosis 25897 NA False True NA 25932 NA False True NA 26192 NA False True NA 26193 NA True False Respiratory electron transport;Complex I biogenesis 26195 NA True False NA 26198 NA True False NA 26201 NA True False Respiratory electron transport;Complex I biogenesis 26202 NA True False Respiratory electron transport;Complex I biogenesis 26204 NA True False NA 26291 NA False True NA 26295 Ogt True True HATs acetylate histones;UCH proteinases 26409 NA False True NA 26519 NA False True NA 26574 AATF False True NA 26759 NA True False Mitochondrial Fatty Acid Beta-Oxidation 26900 NA False True NA 26955 NA True False NA 26956 NA True False NA 26962 NA True False NA 26989 Cadps True True NA 27041 NA False True NA 27139 NA True False NA 27367 NA False True NA 28298 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 29139 Dcn False True Degradation of the extracellular matrix;A tetrasaccharide linker sequence is required for GAG synthesis;Chondroitin sulfate biosynthesis;Dermatan sulfate biosynthesis;CS/DS degradation;ECM proteoglycans 29144 Canx True True MHC class II antigen presentation;Interleukin-35 Signalling;Calnexin/calreticulin cycle;Interleukin-27 signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 29149 NA True False NA 29150 NA True False NA 29154 Capn2 True True Degradation of the extracellular matrix 29158 NA False True Elastic fibre formation;Molecules associated with elastic fibres 29161 Cav3 False True Smooth Muscle Contraction 29167 NA True False NA 29177 NA True False NA 29179 NA True False NA 29205 NA True False Neutrophil degranulation 29209 NA False True NA 29213 NA False True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Kinesins 29214 Tubb5 True True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;AURKA Activation by TPX2 29219 Snca True True NA 29220 NA False True Signaling by PDGF 29221 NA False True Neutrophil degranulation;Urea cycle 29223 NA True False Interconversion of nucleotide di- and triphosphates 29224 NA True False NA 29236 NA True False NA 29254 NA True False Acyl chain remodeling of DAG and TAG;Arachidonate production from DAG 29258 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 29271 Cfl1 True True NA 29272 NA True False NA 29275 NA True False Striated Muscle Contraction 29276 NA True False NA 29278 NA True False NA 29282 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 29283 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 29284 NA True False NA 29286 NA True False NA 29287 NA True False NA 29288 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 29304 NA True False NA 29309 NA False True Ubiquinol biosynthesis 29318 NA True False NA 29331 NA True False ECM proteoglycans 29338 NA True False Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes 29340 Prkce True True NA 29366 NA False True Intrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Dissolution of Fibrin Clot 29374 NA True False Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 29376 Irs2 False True PI3K Cascade;IRS-mediated signalling;SOS-mediated signalling;PIP3 activates AKT signaling;Interleukin-7 signaling;PI3K/AKT activation;IRS-related events triggered by IGF1R;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates RAS 29382 Ctbp1 True True Deactivation of the beta-catenin transactivating complex;SUMOylation of transcription cofactors;Repression of WNT target genes 29383 NA True False NA 29384 NA True False NA 29409 NA True False Axonal growth inhibition (RHOA activation);Basigin interactions 29411 NA True False Fatty acyl-CoA biosynthesis 29423 Gap43 True True L1CAM interactions 29425 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 29428 NA True False NA 29431 Pak1 True True Generation of second messenger molecules;Regulation of actin dynamics for phagocytic cup formation;FCERI mediated MAPK activation;DSCAM interactions;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;Ephrin signaling;Sema3A PAK dependent Axon repulsion;Signal transduction by L1;Smooth Muscle Contraction;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling;G beta:gamma signalling through CDC42 29432 Pak2 False True Generation of second messenger molecules;FCERI mediated MAPK activation;CD28 dependent Vav1 pathway;Ephrin signaling;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling 29433 Pak3 True True Generation of second messenger molecules;CD28 dependent Vav1 pathway;Ephrin signaling;Sema3A PAK dependent Axon repulsion;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling 29437 NA False True Striated Muscle Contraction 29441 NA True False NA 29443 NA True False Methylation;Sulfur amino acid metabolism 29445 NA True False NA 29448 NA True False MHC class II antigen presentation;Neutrophil degranulation;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 29456 Map1b True True NA 29457 NA True False NA 29468 NA True False NA 29473 Aoc3 False True Phase I - Functionalization of compounds 29474 NA True False NA 29477 Mapt False True Caspase-mediated cleavage of cytoskeletal proteins 29482 NA True False NA 29483 NA True False Astrocytic Glutamate-Glutamine Uptake And Metabolism;Glutamate Neurotransmitter Release Cycle;Transport of inorganic cations/anions and amino acids/oligopeptides 29489 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2 29491 Itsn1 True True NRAGE signals death through JNK;Rho GTPase cycle;EPHB-mediated forward signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 29495 Dlg4 True True Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Activation of Ca-permeable Kainate Receptor;RHO GTPases activate CIT;RAF/MAP kinase cascade;LGI-ADAM interactions;Neurexins and neuroligins;Synaptic adhesion-like molecules 29507 NA True False NA 29511 NA True False NA 29521 NA True False NA 29525 NA True False NA 29527 Ptgs2 False True Nicotinamide salvaging;Synthesis of 15-eicosatetraenoic acid derivatives;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Biosynthesis of EPA-derived SPMs;Biosynthesis of DPAn-3 SPMs;Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives 29539 Aldh2 True True Ethanol oxidation 29542 Pebp1 True True MAP2K and MAPK activation;Negative regulation of MAPK pathway 29545 Uchl1 True True UCH proteinases 29546 Homer1 True True Neurexins and neuroligins 29547 Homer2 False True Neurexins and neuroligins 29548 Homer3 True True Neurexins and neuroligins 29555 NA False True G alpha (s) signalling events;Glucagon-type ligand receptors 29557 NA False True NA 29561 NA True False NA 29562 Prps1 True True 5-Phosphoribose 1-diphosphate biosynthesis 29564 Dync1i1 True True NA 29565 NA True False Peptide chain elongation;Synthesis of diphthamide-EEF2;Neutrophil degranulation;Protein methylation 29578 NA True False NA 29592 NA True False Branched-chain amino acid catabolism 29598 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases 29599 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases 29600 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases 29627 Gria2 True True NA 29628 NA True False Activation of AMPA receptors;Trafficking of AMPA receptors;Trafficking of GluR2-containing AMPA receptors;Synaptic adhesion-like molecules 29630 Psme1 False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 29635 NA False True NA 29637 NA True False Cholesterol biosynthesis 29647 Cask True True NA 29648 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Mitotic Telophase/Cytokinesis 29660 NA False True NA 29662 NA True False Rho GTPase cycle;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs 29663 NA True False MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis 29666 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 29668 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 29669 Psma2 True True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation 29670 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 29671 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 29673 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 29675 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 29677 Psmc3 True True NA 29681 NA True False Intrinsic Pathway of Fibrin Clot Formation 29682 Kcnq3 False True NA 29691 NA False True Cam-PDE 1 activation;cGMP effects;G alpha (s) signalling events 29693 NA True False Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases 29699 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;Hedgehog 'off' state;Factors involved in megakaryocyte development and platelet production 29704 NA True False NA 29705 NA True False GABA A receptor activation 29715 Slc8a1 True True Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis 29738 Kcnab2 True True Voltage gated Potassium channels;Neutrophil degranulation 29748 NA True False Activation of BAD and translocation to mitochondria ;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation 29752 NA False True NA 29753 NA True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Signaling by Hippo;NADE modulates death signalling;Regulation of PLK1 Activity at G2/M Transition;Regulation of HSF1-mediated heat shock response;HSF1 activation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;RAB GEFs exchange GTP for GDP on RABs 29757 NA True False ROS, RNS production in phagocytes;Neutrophil degranulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 50522 Ubc False True NA 50557 Pten False True Synthesis of PIPs at the plasma membrane;Synthesis of IP3 and IP4 in the cytosol;Negative regulation of the PI3K/AKT network;Downstream TCR signaling;Ub-specific processing proteases;Ovarian tumor domain proteases;Regulation of PTEN localization;Regulation of PTEN stability and activity 50567 NA True False Basigin interactions;Amino acid transport across the plasma membrane;Tryptophan catabolism 50592 Gria1 True True NA 50646 Ptk2b True True Signal regulatory protein family interactions;VEGFA-VEGFR2 Pathway;Interleukin-2 signaling 50655 NA True False NA 50663 NA True False CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;Platelet degranulation ;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;eNOS activation;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;VEGFR2 mediated vascular permeability;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Glycogen breakdown (glycogenolysis);Protein methylation;Ion transport by P-type ATPases;Activation of RAC1 downstream of NMDARs;Long-term potentiation 50664 Gnao1 True True PLC beta mediated events;G-protein activation;Ca2+ pathway;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 50671 NA True False ChREBP activates metabolic gene expression;Vitamin B5 (pantothenate) metabolism;Fatty acyl-CoA biosynthesis 50686 NA True False NA 50687 L1cam True True Basigin interactions;L1CAM interactions;Recycling pathway of L1;Interaction between L1 and Ankyrins;Signal transduction by L1 50689 Mapk3 True True MAPK3 (ERK1) activation;RAF-independent MAPK1/3 activation;ISG15 antiviral mechanism;Spry regulation of FGF signaling;Golgi Cisternae Pericentriolar Stack Reorganization;Frs2-mediated activation;ERK/MAPK targets;ERKs are inactivated;Regulation of actin dynamics for phagocytic cup formation;Senescence-Associated Secretory Phenotype (SASP);NCAM signaling for neurite out-growth;Signal transduction by L1;Activation of the AP-1 family of transcription factors;Thrombin signalling through proteinase activated receptors (PARs);Negative regulation of FGFR1 signaling;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RNA Polymerase I Promoter Opening;Signal attenuation;Gastrin-CREB signalling pathway via PKC and MAPK;Growth hormone receptor signaling 50693 NA True False Platelet degranulation 50719 NA True False Basigin interactions;Amino acid transport across the plasma membrane;Tryptophan catabolism 50818 NA False True NA 50861 NA False True NA 50864 NA True False NA 51776 NA False True NA 51788 NA False True NA 53319 NA False True NA 53356 NA False True NA 53381 NA False True NA 54226 App True True Platelet degranulation ;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;G alpha (i) signalling events;Lysosome Vesicle Biogenesis;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Advanced glycosylation endproduct receptor signaling;Post-translational protein phosphorylation;TRAF6 mediated NF-kB activation 54231 NA True False Erythrocytes take up carbon dioxide and release oxygen;Reversible hydration of carbon dioxide 54241 NA True False NA 54245 Crk True True ARMS-mediated activation;Downstream signal transduction;Regulation of actin dynamics for phagocytic cup formation;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;MET receptor recycling;Regulation of signaling by CBL 54248 NA True False NA 54257 Grik2 False True Activation of Na-permeable kainate receptors;Activation of Ca-permeable Kainate Receptor 54293 NA False True G alpha (q) signalling events;G alpha (i) signalling events 54296 NA True False NA 54308 NA True False NA 54318 NA False True L13a-mediated translational silencing of Ceruloplasmin expression;PERK regulates gene expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP 54319 NA True False Netrin-1 signaling;Recycling pathway of L1 54321 Cnn3 False True NA 54322 NA True False NA 54323 Arc False True NA 54348 NA True False NA 54709 NA False True NA 55172 NA False True NA 55651 NA False True NA 55803 NA False True NA 55810 NA False True NA 56003 NA True False NA 56010 NA True False Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Regulation of localization of FOXO transcription factors 56011 Ywhab True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;mTOR signalling;mTORC1-mediated signalling;Signaling by Hippo;Rap1 signalling;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors 56012 NA False True NA 56029 Srcin1 True True NA 56040 NA False True NA 56042 NA True False COPII-mediated vesicle transport;COPI-mediated anterograde transport 56064 NA True False NA 56084 Hgs True True NA 56086 NA False True NA 56227 Espn False True NA 56403 NA False True NA 56456 NA False True NA 56611 NA False True Neutrophil degranulation;Dissolution of Fibrin Clot 56646 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 56718 Mtor True True PIP3 activates AKT signaling;Macroautophagy;mTOR signalling;mTORC1-mediated signalling;HSF1-dependent transactivation;Energy dependent regulation of mTOR by LKB1-AMPK;CD28 dependent PI3K/Akt signaling;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription 56768 NA True False NA 56781 NA False True Striated Muscle Contraction 56783 Eif5 True True Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 56813 NA False True Class B/2 (Secretin family receptors);G alpha (s) signalling events 56816 Park2 False True NA 56941 NA False True NA 57048 NA False True NA 57118 NA False True NA 57120 GOPC False True NA 58814 NA True False Striated Muscle Contraction 58815 NA True False NA 58819 NA False True NA 58823 NA True False NA 58835 NA True False Serine biosynthesis 58857 NA True False Sphingolipid de novo biosynthesis;Neutrophil degranulation 58917 NA True False Scavenging of heme from plasma 58920 NA True False NA 58940 NA True False NA 58945 NA False True NA 58948 NA True False Unblocking of NMDA receptors, glutamate binding and activation;Activation of Ca-permeable Kainate Receptor;RAF/MAP kinase cascade;Neurexins and neuroligins;Synaptic adhesion-like molecules 58953 NA True False Cytosolic sulfonation of small molecules 58959 NA False True Class B/2 (Secretin family receptors);G alpha (s) signalling events 58974 Gabarap False True Macroautophagy;TBC/RABGAPs 59069 NA False True NA 59114 Slc9a3r1 True True NA 59312 Shank3 False True NA 59317 NA True False Trafficking of AMPA receptors;Neurexins and neuroligins 59322 NA True False MAP2K and MAPK activation 59323 Erbb4 False True NA 60324 NA True False NA 60331 Atxn3 False True Josephin domain DUBs;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 60335 NA False True Formation of the cornified envelope 60341 Camkk1 True True CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Activation of RAC1 downstream of NMDARs 60355 NA True False NA 60377 NA False True Dopamine Neurotransmitter Release Cycle;RHO GTPases Activate Rhotekin and Rhophilins 60383 Rbck1 False True Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Antigen processing: Ubiquitination & Proteasome degradation 60384 NA False True NA 60391 Nrxn1 True True NA 60416 NA True False NA 60431 NA True False Sphingolipid de novo biosynthesis 60432 NA False True G alpha (s) signalling events;Glucagon-type ligand receptors 60443 NA False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 60445 Tsc1 False True Macroautophagy;Inhibition of TSC complex formation by PKB;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;TBC/RABGAPs 60465 NA True False Clathrin-mediated endocytosis 60466 NA True False NA 60562 Stx6 True True Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network 60581 NA True False NA 60666 NA True False Synthesis of PA 60668 Amph True True NA 63836 NA True False Platelet degranulation 63837 NA True False NA 63839 NA False True NA 63864 NA True False Branched-chain amino acid catabolism 63868 Hspd1 True True NA 63879 Xiap False True SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;SMAC, XIAP-regulated apoptotic response;Deactivation of the beta-catenin transactivating complex;RIPK1-mediated regulated necrosis;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Regulation of necroptotic cell death;Regulation of PTEN localization;Regulation of PTEN stability and activity 63938 NA True False Branched-chain amino acid catabolism 64001 NA True False Vitamin C (ascorbate) metabolism 64040 NA True False Carnitine synthesis 64053 NA True False NA 64057 NA True False NA 64156 NA True False NA 64157 NA True False eNOS activation 64158 Tuba1a True True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Kinesins 64159 Sptan1 True True Caspase-mediated cleavage of cytoskeletal proteins;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;Neutrophil degranulation;COPI-mediated anterograde transport 64160 NA True False NA 64161 NA True False NA 64169 NA True False NA 64185 NA True False Neutrophil degranulation 64189 NA True False Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic 64192 NA True False Phenylalanine and tyrosine catabolism 64200 NA True False FGFR2 alternative splicing;mRNA Splicing - Major Pathway 64201 NA True False NA 64202 Calr True True ER-Phagosome pathway;Scavenging by Class A Receptors;Calnexin/calreticulin cycle;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 64204 NA False True Assembly of collagen fibrils and other multimeric structures;Caspase-mediated cleavage of cytoskeletal proteins;Type I hemidesmosome assembly 64205 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 64298 NA True False NA 64300 NA True False NA 64302 NA True False NA 64303 NA False True Signaling by ROBO receptors;PCP/CE pathway;RHO GTPases Activate Formins 64304 NA False True Beta oxidation of butanoyl-CoA to acetyl-CoA 64306 NA True False NA 64307 NA True False NA 64310 NA True False Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;MHC class II antigen presentation;Clathrin derived vesicle budding;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Intra-Golgi traffic 64313 NA True False Amino acid synthesis and interconversion (transamination) 64351 NA True False COPII-mediated vesicle transport;COPI-mediated anterograde transport;Intra-Golgi traffic 64352 NA True False Glutathione conjugation 64356 Nrgn True True Long-term potentiation 64363 NA False True RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway 64367 NA True False Collagen biosynthesis and modifying enzymes 64371 NA True False NA 64373 NA True False GPVI-mediated activation cascade;Rho GTPase cycle;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases Activate Formins 64392 NA True False NA 64465 Cdc42 True True GPVI-mediated activation cascade;EGFR downregulation;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;G beta:gamma signalling through CDC42;Factors involved in megakaryocyte development and platelet production 64473 NA True False Cytosolic sulfonation of small molecules 64507 NA False True NA 64515 Cdc20 False True Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;Inactivation of APC/C via direct inhibition of the APC/C complex;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;APC/C:Cdc20 mediated degradation of Cyclin B;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of Emi1;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Ub-specific processing proteases;Mitotic Prometaphase;Antigen processing: Ubiquitination & Proteasome degradation 64517 NA True False Antigen processing: Ubiquitination & Proteasome degradation 64524 NA True False NA 64525 NA True False Formation of RNA Pol II elongation complex ;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 64526 NA True False Peroxisomal protein import 64527 NA False True Neutrophil degranulation 64533 NA True False Vitamins B6 activation to pyridoxal phosphate 64547 Bcl2l11 False True Activation of BIM and translocation to mitochondria ;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;NRAGE signals death through JNK 64551 NA True False MAPK6/MAPK4 signaling 64553 NA True False NA 64627 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 64633 NA True False NA 64635 NA True False NA 64640 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 64646 NA True False NA 64647 NA True False NA 64664 NA True False NA 64665 NA True False Synaptic adhesion-like molecules 64667 Sgta True True NA 64672 NA False True Ion homeostasis;Ion transport by P-type ATPases 64681 NA False True Neutrophil degranulation 64701 NA True False NA 64829 NA True False NA 64845 Gphn True True NA 64862 Map1lc3b False True NA 65028 NA True False NA 65033 NA True False NA 65040 Dlgap1 False True Neurexins and neuroligins 65042 NA True False NA 65046 NA True False Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 65114 NA False True NA 65136 NA True False NA 65137 Ruvbl1 True True UCH proteinases;Ub-specific processing proteases;DNA Damage Recognition in GG-NER;Deposition of new CENPA-containing nucleosomes at the centromere 65138 NA False True UCH proteinases;Ub-specific processing proteases 65151 NA True False Threonine catabolism 65152 NA True False NA 65158 NA True False NA 65171 NA True False NA 65178 Snap91 True True NA 65179 NA True False Negative regulation of MAPK pathway;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;ESR-mediated signaling 65183 NA True False Sphingolipid de novo biosynthesis;Alpha-oxidation of phytanate 65208 NA True False CRMPs in Sema3A signaling 65218 Agap2 True True NA 65262 NA True False NA 65997 NA False True NA 66028 NA True False NA 66030 NA True False NA 66031 NA True False NA 66108 NA False True NA 66475 NA False True NA 66480 NA False True NA 66511 NA False True NA 66592 NA False True NA 66870 NA False True NA 67059 NA False True NA 67097 NA False True NA 67115 NA False True NA 67186 NA False True NA 67332 NA False True NA 67427 NA False True NA 67628 NA False True NA 67738 NA False True NA 67891 NA False True NA 67958 NA False True NA 67979 NA False True NA 68349 NA False True NA 71679 NA False True NA 72900 NA False True NA 73333 NA False True NA 73830 NA False True NA 75273 NA False True NA 75705 NA False True NA 76808 NA False True NA 78957 Shank1 True True Neurexins and neuroligins 78959 NA True False Glutathione conjugation;Formation of xylulose-5-phosphate 79011 NA True False NA 79039 NA False True NA 79117 NA True False COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 79130 NA True False Neutrophil degranulation;GABA synthesis, release, reuptake and degradation 79131 NA False True Triglyceride catabolism 79212 NA True False Na+/Cl- dependent neurotransmitter transporters;Reuptake of GABA 79213 NA True False Na+/Cl- dependent neurotransmitter transporters;Creatine metabolism;Reuptake of GABA 79239 NA True False Heme degradation;Neutrophil degranulation;Iron uptake and transport 79244 NA False True Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import 79249 NA True False Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs 79250 NA True False Citric acid cycle (TCA cycle) 79251 NA True False Amino acid synthesis and interconversion (transamination) 79256 NA True False AUF1 (hnRNP D0) binds and destabilizes mRNA;mRNA Splicing - Major Pathway 79257 Axin1 False True NA 79433 NA True False NA 79434 Rab11b True True TBC/RABGAPs;RAB geranylgeranylation 79449 NA False True NA 79451 NA False True NA 79559 NA True False NA 80773 NA True False Phase I - Functionalization of compounds 80841 NA True False Triglyceride catabolism 80846 NA True False mRNA Splicing - Major Pathway 80849 NA True False NA 81022 Stxbp5 True True NA 81504 Grb2 True True PI3K Cascade;SOS-mediated signalling;SHC1 events in ERBB4 signaling;PIP3 activates AKT signaling;Spry regulation of FGF signaling;Signaling by SCF-KIT;Regulation of KIT signaling;Signalling to RAS;GRB2 events in EGFR signaling;GAB1 signalosome;SHC1 events in EGFR signaling;EGFR downregulation;Downstream signal transduction;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Regulation of actin dynamics for phagocytic cup formation;Tie2 Signaling;EGFR Transactivation by Gastrin;DAP12 signaling;SHC-related events triggered by IGF1R;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;GRB2:SOS provides linkage to MAPK signaling for Integrins ;NCAM signaling for neurite out-growth;Costimulation by the CD28 family;CD28 dependent Vav1 pathway;Signal regulatory protein family interactions;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;Negative regulation of MET activity;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Insulin receptor signalling cascade;MET activates RAS signaling;MET activates PI3K/AKT signaling;RET signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;MET activates PTPN11;MET activates RAP1 and RAC1;MET receptor recycling;Interleukin-15 signaling;Erythropoietin activates RAS;Activated NTRK2 signals through FRS2 and FRS3;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 81515 Lyn False True GPVI-mediated activation cascade;Signaling by SCF-KIT;Regulation of KIT signaling;Cell surface interactions at the vascular wall;FCGR activation;Fc epsilon receptor (FCERI) signaling;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;CD28 co-stimulation;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;CD209 (DC-SIGN) signaling;CD22 mediated BCR regulation;Cyclin D associated events in G1;Platelet Adhesion to exposed collagen;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates RAS;Regulation of signaling by CBL;Growth hormone receptor signaling 81529 NA False True NA 81530 NA True False NA 81531 NA True False Signaling by ROBO receptors;RHO GTPases Activate Formins 81632 NA True False Degradation of GABA 81634 NA True False Platelet degranulation ;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 81637 Ap2a2 False True Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Neutrophil degranulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 81643 NA True False Purine ribonucleoside monophosphate biosynthesis 81650 Csnk2b True True WNT mediated activation of DVL;Signal transduction by L1;Neutrophil degranulation;Regulation of TP53 Activity through Phosphorylation;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity 81653 Dbn1 True True NA 81654 NA True False Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism 81661 NA True False NA 81662 NA True False NA 81664 NA True False PLC beta mediated events;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 81666 NA True False NA 81667 NA True False Activation of G protein gated Potassium channels;G-protein activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 81672 Grm7 False True NA 81677 NA True False Synthesis of IP3 and IP4 in the cytosol 81682 NA False True Keratan sulfate biosynthesis;Keratan sulfate degradation;Integrin cell surface interactions 81683 NA True False Cell surface interactions at the vascular wall;Neutrophil degranulation 81708 NA True False Branched-chain amino acid catabolism 81722 Ager False True TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Advanced glycosylation endproduct receptor signaling;TRAF6 mediated NF-kB activation 81728 NA True False Respiratory electron transport;Complex I biogenesis 81732 NA True False Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis 81743 NA True False cGMP effects;G alpha (s) signalling events 81753 NA False True NA 81754 NA True False Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 81757 Rala True True Translocation of SLC2A4 (GLUT4) to the plasma membrane 81761 NA True False NA 81763 NA True False NA 81764 NA True False NA 81765 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 81766 NA True False NA 81767 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 81768 NA False True NA 81772 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 81773 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 81774 NA False True NA 81779 NA False True NA 81783 NA False True NA 81800 NA True False NA 81802 Stx3 False True Other interleukin signaling 81804 Stxbp2 False True NA 81807 Tceb2 True True Formation of RNA Pol II elongation complex ;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 81815 NA True False Antigen processing: Ubiquitination & Proteasome degradation 81818 NA True False NA 81822 Actb True True Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Adherens junctions interactions;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;B-WICH complex positively regulates rRNA expression;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;MAP2K and MAPK activation;UCH proteinases;DNA Damage Recognition in GG-NER;Clathrin-mediated endocytosis 81824 NA True False NA 81827 Psmc5 True True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 81829 NA True False Citric acid cycle (TCA cycle) 81869 NA True False Glutathione conjugation 81898 NA False True NA 81921 NA True False EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 81922 Sh3gl1 True True EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 83422 NA False True NA 83427 NA True False Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production 83471 NA True False NA 83501 NA True False NA 83506 Camkk2 False True NA 83510 NA True False L1CAM interactions 83523 NA True False NA 83527 NA True False Caspase-mediated cleavage of cytoskeletal proteins;Neurexins and neuroligins;Neutrophil degranulation 83529 Vdac1 True True Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases;Pyruvate metabolism 83531 NA True False Ub-specific processing proteases 83532 NA True False NA 83533 NA False True NA 83534 NA True False NA 83572 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2 83576 NA True False Golgi Associated Vesicle Biogenesis 83578 NA True False NA 83579 NA True False NA 83589 Apba1 False True NA 83610 Apba2 False True NA 83612 NA True False Transport of inorganic cations/anions and amino acids/oligopeptides;GABA synthesis, release, reuptake and degradation 83613 Nefl True True Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade 83615 NA True False NA 83616 NA True False NA 83688 NA True False Pentose phosphate pathway 83707 NA False True NA 83709 Git1 True True NA 83712 NA True False PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;PKMTs methylate histone lysines;HATs acetylate histones;RMTs methylate histone arginines;Deposition of new CENPA-containing nucleosomes at the centromere;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Neddylation;Transcriptional Regulation by E2F6 83718 Clic4 True True NA 83725 Wfs1 False True NA 83731 Kcnma1 True True Ca2+ activated K+ channels 83764 NA True False Synaptic adhesion-like molecules 83765 Rtn4 True True Axonal growth inhibition (RHOA activation) 83782 Nme2 True True Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation 83788 NA True False NA 83789 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;RMTs methylate histone arginines;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Protein methylation;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 83800 Clta True True Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 83806 NA True False NA 83807 NA False True NA 83809 Nsfl1c True True NA 83823 NA True False NA 83824 Cxxc4 False True NA 83825 NA True False NA 83839 NA True False NA 83841 Sdcbp False True Ephrin signaling;Neurofascin interactions;Neutrophil degranulation 84008 NA True False NA 84013 NA False True Androgen biosynthesis;Synthesis of very long-chain fatty acyl-CoAs 84014 NA False True NA 84016 NA False True NA 84027 Gsk3b False True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;CRMPs in Sema3A signaling;Disassembly of the destruction complex and recruitment of AXIN to the membrane;B-WICH complex positively regulates rRNA expression 84309 NA False True NA 84310 NA False True NA 84353 Ctnnb1 True True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;TCF dependent signaling in response to WNT;Formation of the beta-catenin:TCF transactivating complex;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Apoptotic cleavage of cell adhesion proteins;CDO in myogenesis;Deactivation of the beta-catenin transactivating complex;Ca2+ pathway;Adherens junctions interactions;VEGFR2 mediated vascular permeability;RHO GTPases activate IQGAPs;RUNX3 regulates WNT signaling 84356 NA False True NA 84379 NA True False Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 84431 NA True False Glycosphingolipid metabolism;Neutrophil degranulation 84469 Maged1 False True NA 84471 NA True False NA 84472 NA True False NA 84474 NA True False NA 84478 Ufd1l False True Translesion Synthesis by POLH;Ub-specific processing proteases 84479 NA False True NA 84484 NA True False Bicarbonate transporters 84496 NA False True NA 84509 NA True False NA 84550 NA True False Sodium/Calcium exchangers 84556 NA True False Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation 84591 Pick1 False True NA 84685 Ppp1r9a True True NA 84686 NA True False NA 85238 Synj1 True True Synthesis of PIPs at the plasma membrane;Synthesis of IP2, IP, and Ins in the cytosol;Synthesis of IP3 and IP4 in the cytosol;Clathrin-mediated endocytosis 85252 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Deactivation of the beta-catenin transactivating complex;HuR (ELAVL1) binds and stabilizes mRNA;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;Mitotic Prometaphase;Cyclin A/B1/B2 associated events during G2/M transition 85254 NA True False Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Choline catabolism 85309 NA True False NA 85327 Lin7a True True NA 85333 NA True False NA 85492 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation 89789 NA False True NA 89791 NA True False NA 89841 NA True False Synthesis of PE 89953 NA False True NA 90933 NA False True NA 93646 NA True False COPII-mediated vesicle transport;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 94167 Prdx6 True True Detoxification of Reactive Oxygen Species;Neutrophil degranulation 94173 NA True False Citric acid cycle (TCA cycle) 94193 NA True False Regulation of TNFR1 signaling;RAB GEFs exchange GTP for GDP on RABs 94194 NA True False NA 94197 NA True False Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 94266 NA False True NA 97165 NA False True NA 98221 NA False True NA 98238 NA False True NA 101706 NA False True NA 107686 NA False True NA 107932 NA False True NA 108017 NA False True NA 108071 NA False True NA 108989 NA False True NA 110611 NA False True NA 110954 NA False True NA 110957 NA False True NA 112295 Lmb1 False True NA 113893 NA True False NA 113894 Sqstm1 False True NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Pink/Parkin Mediated Mitophagy;Interleukin-1 signaling 113898 NA True False NA 113965 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 113970 Magi2 False True NA 114005 NA False True Glycogen synthesis 114017 NA False True Mitochondrial translation elongation 114023 NA False True Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 114096 NA True False NA 114101 NA True False NA 114114 Dnm1l True True Apoptotic execution phase 114122 NA True False NA 114202 NA True False NA 114486 Braf False True NA 114513 NA True False NA 114514 NA True False Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 114515 NA True False NA 114520 NA True False NA 114562 NA True False NA 114591 NA True False NA 114597 NA True False NA 114612 NA True False Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing 114641 NA False True NA 114766 NA True False Processing of SMDT1 115769 NA False True Signaling by Hippo;Apoptotic cleavage of cell adhesion proteins 116463 NA True False Estrogen biosynthesis;Retinoid metabolism and transport 116470 Stx1a True True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Other interleukin signaling;LGI-ADAM interactions;GABA synthesis, release, reuptake and degradation 116482 NA True False Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the Golgi membrane 116483 NA True False NA 116484 NA True False NA 116493 NA True False NA 116506 NA False True G alpha (s) signalling events;Calcitonin-like ligand receptors 116508 Nrxn3 True True NA 116509 NA True False Na+/Cl- dependent neurotransmitter transporters 116549 Csnk2a1 True True WNT mediated activation of DVL;Signal transduction by L1;Regulation of TP53 Activity through Phosphorylation;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity 116561 NA True False Gap junction degradation;Formation of annular gap junctions;Lysosome Vesicle Biogenesis;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 116563 NA True False Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 116590 Mapk1 True True phospho-PLA2 pathway;RAF-independent MAPK1/3 activation;MAPK1 (ERK2) activation;Spry regulation of FGF signaling;Golgi Cisternae Pericentriolar Stack Reorganization;Frs2-mediated activation;ERK/MAPK targets;ERKs are inactivated;Regulation of actin dynamics for phagocytic cup formation;Senescence-Associated Secretory Phenotype (SASP);NCAM signaling for neurite out-growth;Recycling pathway of L1;Signal transduction by L1;Activation of the AP-1 family of transcription factors;Thrombin signalling through proteinase activated receptors (PARs);Negative regulation of FGFR1 signaling;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Neutrophil degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Gastrin-CREB signalling pathway via PKC and MAPK;Growth hormone receptor signaling 116595 Nrxn2 True True Neurexins and neuroligins 116597 NA True False NA 116598 Pdia4 False True NA 116599 NA True False Heme degradation 116636 NA False True mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 116638 NA True False Glutamate Neurotransmitter Release Cycle;Organic anion transporters 116643 Vcp True True Translesion Synthesis by POLH;HSF1 activation;ABC-family proteins mediated transport;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Hedgehog ligand biogenesis;Josephin domain DUBs;Ovarian tumor domain proteases;Neutrophil degranulation 116644 Rtn1 True True NA 116646 NA True False NA 116653 NA True False NA 116655 Hnrnpm True True FGFR2 alternative splicing;mRNA Splicing - Major Pathway 116657 NA True False NA 116673 NA False True A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG biosynthesis;HS-GAG degradation;Cell surface interactions at the vascular wall;Syndecan interactions;Retinoid metabolism and transport 116685 Lmnb1 True True NA 116690 Nfasc True True Neurofascin interactions;Neutrophil degranulation 116698 NA True False Generic Transcription Pathway 116723 NA True False NA 116725 NA True False ISG15 antiviral mechanism;NOD1/2 Signaling Pathway;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;CLEC7A (Dectin-1) signaling;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;E3 ubiquitin ligases ubiquitinate target proteins;Interleukin-1 signaling;IRAK1 recruits IKK complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation 116743 Sh3gl2 True True Retrograde neurotrophin signalling;EGFR downregulation;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 117024 NA True False NA 117028 Bin1 True True Clathrin-mediated endocytosis 117030 NA True False NA 117042 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 117044 NA True False Macroautophagy;mTOR signalling;mTORC1-mediated signalling;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;E3 ubiquitin ligases ubiquitinate target proteins;Regulation of PTEN gene transcription 117053 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 117056 H3f3b True True PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production 117099 NA False True Synthesis of Ketone Bodies 117104 NA True False Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 117152 Cand1 True True Neutrophil degranulation;Neddylation;Iron uptake and transport 117180 NA True False NA 117243 NA True False Synthesis of very long-chain fatty acyl-CoAs 117254 NA True False Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes 117258 NA True False NA 117262 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 117263 Psmc1 True True Autodegradation of Cdh1 by Cdh1:APC/C;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 117272 NA True False NA 117273 Rhoa True True GPVI-mediated activation cascade;Axonal growth inhibition (RHOA activation);Rho GTPase cycle;PI3K/AKT activation;Axonal growth stimulation;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);G beta:gamma signalling through PI3Kgamma;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;PCP/CE pathway;G alpha (12/13) signalling events;Sema4D mediated inhibition of cell attachment and migration;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases Activate ROCKs;RHO GTPases Activate Formins;RHO GTPases Activate Rhotekin and Rhophilins;Ovarian tumor domain proteases;ERBB2 Regulates Cell Motility;Neutrophil degranulation;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;SLIT2:ROBO1 increases RHOA activity 117277 Epn1 True True NA 117282 NA True False mRNA Splicing - Major Pathway 117284 Lrrc7 True True Unblocking of NMDA receptors, glutamate binding and activation;RAF/MAP kinase cascade;Neutrophil degranulation 117287 Park7 True True SUMOylation of transcription cofactors 117515 NA True False Anchoring of the basal body to the plasma membrane 117520 NA True False NA 117526 Tbp False True B-WICH complex positively regulates rRNA expression;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA polymerase II transcribes snRNA genes;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase I Transcription Termination;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;Estrogen-dependent gene expression 117533 NA True False NA 117542 Baiap2 True True Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs 117543 NA True False mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 117548 NA True False COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 117550 NA True False MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 117556 NA True False NA 117557 NA True False Striated Muscle Contraction;Smooth Muscle Contraction 117559 NA True False NA 117596 NA True False ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 122772 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 122799 NA True False NA 124323 NA True False NA 124461 NA True False Clathrin-mediated endocytosis 126308 NA False True NA 140290 NA False True NA 140447 NA True False NA 140448 NA True False Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis 140547 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 140593 Siah2 False True Netrin-1 signaling;Ub-specific processing proteases;Antigen processing: Ubiquitination & Proteasome degradation 140597 NA False True NA 140608 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation 140639 Nploc4 False True NA 140654 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 140655 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 140661 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 140662 NA False True NA 140667 NA True False NA 140670 Ap2b1 True True Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 140671 NA False True Glycogen breakdown (glycogenolysis) 140673 NA True False COPII-mediated vesicle transport;Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network 140694 Dnm1 True True Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;Recycling pathway of L1;Clathrin-mediated endocytosis 140722 Caskin1 True True NA 140729 NA True False NA 140734 NA True False Activation of BMF and translocation to mitochondria;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Macroautophagy;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Intraflagellar transport;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase 140868 NA True False Triglyceride catabolism;Signaling by Retinoic Acid;Neutrophil degranulation 140908 Cdk5 True True DARPP-32 events;CRMPs in Sema3A signaling;Regulation of TP53 Activity through Phosphorylation 140922 NA True False NA 140926 Daxx False True SUMOylation of transcription cofactors;Regulation of TP53 Degradation 140927 NA True False NA 140931 NA False True NA 140941 Siah1 False True Netrin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation 140945 NA True False Synaptic adhesion-like molecules 146227 NA False True NA 148252 NA False True NA 154968 NA True False NA 155151 NA True False NA 156275 NA True False Aflatoxin activation and detoxification 157074 NA True False Citric acid cycle (TCA cycle) 161475 Psmd9 True True NA 161477 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 170082 NA False True NA 170465 NA True False NA 170538 Prkcd False True NA 170587 NA True False NA 170667 NA True False ROS, RNS production in phagocytes;Neutrophil degranulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 170670 NA True False Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA 170673 NA True False NA 170724 NA True False NA 170751 NA True False NA 170821 Atxn10 False True NA 170840 Slc40a1 False True Metal ion SLC transporters;Iron uptake and transport 170848 Kcnq2 False True NA 170851 Map2k1 True True NA 170915 Ep300 False True NA 170916 NA True False NA 170923 NA True False Neutrophil degranulation 170930 NA False True NA 171026 NA False True Trafficking of AMPA receptors;ROBO receptors bind AKAP5 171039 NA True False NA 171041 Klc1 True True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 171050 Mob4 False True NA 171058 NA True False RAB geranylgeranylation 171082 NA False True Formation of ATP by chemiosmotic coupling;Cristae formation 171086 Trak2 False True NA 171093 NA True False NA 171102 Cdc25a False True NA 171103 Cdc25b False True NA 171114 NA True False NA 171116 NA True False Regulation of Apoptosis 171119 NA True False NA 171129 NA True False NA 171137 NA True False KSRP (KHSRP) binds and destabilizes mRNA 171140 NA True False HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Interferon gamma signaling;Ion transport by P-type ATPases 171155 NA True False Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA 171297 NA True False Neurexins and neuroligins 171337 NA True False NA 171350 Pabpc1 True True L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 171361 NA True False NA 171373 NA True False NA 171374 NA True False NA 171375 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation 171410 NA True False Synthesis of very long-chain fatty acyl-CoAs 171444 NA True False NA 171445 NA True False NA 171451 NA True False Phase I - Functionalization of compounds 171503 NA True False Activation of RAC1 downstream of NMDARs 171574 NA True False MHC class II antigen presentation;Recycling pathway of L1;Clathrin-mediated endocytosis 191575 NA True False Interconversion of nucleotide di- and triphosphates 191576 NA True False Synthesis of very long-chain fatty acyl-CoAs 191595 NA True False NA 192117 NA False True Regulation of RAS by GAPs 192152 Tgoln2 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Golgi Associated Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation 192172 NA True False Degradation of cysteine and homocysteine 192176 NA False True NA 192179 NA True False NA 192213 NA True False NA 192226 NA False True NA 192235 Hyou1 True True NA 192241 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation 192245 Hspb6 False True NA 192249 NA True False Factors involved in megakaryocyte development and platelet production 192253 NA True False NA 192254 Grasp False True NA 192255 NA False True NA 192260 NA True False Synthesis of PI 192268 NA True False Glutamate Neurotransmitter Release Cycle;TP53 Regulates Metabolic Genes;Amino acid synthesis and interconversion (transamination) 192277 NA True False HSP90 chaperone cycle for steroid hormone receptors (SHR) 192645 NA True False NA 192647 NA False True NA 201097 NA True False NA 208691 NA False True NA 217337 NA False True NA 217737 NA False True NA 218490 NA False True NA 223696 NA False True NA 228410 NA False True NA 229279 NA False True NA 230908 NA False True NA 231887 NA False True NA 234594 NA False True NA 245709 NA True False Insulin processing;VxPx cargo-targeting to cilium 245955 NA False True Platelet degranulation 245965 NA True False NA 245981 NA True False Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 246118 Tubb3 True True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins 246136 NA False True NA 246302 NA True False NA 246303 NA True False NA 246307 NA True False Phenylalanine and tyrosine catabolism 246310 Arfgap1 True True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Clathrin-mediated endocytosis 246755 NA True False NA 246757 Klhl17 False True NA 246772 NA True False NA 252881 NA True False Insulin processing;VxPx cargo-targeting to cilium 252892 NA True False LGI-ADAM interactions 252902 NA True False NA 252919 NA True False Amino acid transport across the plasma membrane 252921 NA False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 252922 NA True False NA 252934 NA True False NA 259242 NA True False Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs 259269 NA True False NA 259274 NA True False Inactivation, recovery and regulation of the phototransduction cascade;Activation, myristolyation of BID and translocation to mitochondria 260321 NA True False HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;ESR-mediated signaling;Estrogen-dependent gene expression 261736 NA True False DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation 261737 NA True False NA 266759 Hspa4 True True NA 266777 NA True False NA 266975 NA True False NA 267019 NA False True NA 268373 NA False True NA 269610 NA False True NA 276770 NA False True NA 281165 NA False True NA 281296 NA False True NA 282587 NA True False NA 282827 Aip False True Aryl hydrocarbon receptor signalling 282843 Sorbs3 False True Smooth Muscle Contraction 284273 NA False True NA 286761 NA True False Ovarian tumor domain proteases 286770 DNAJC3 False True NA 286906 NA True False Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 286911 NA False True NA 286928 NA False True NA 286930 NA True False NA 287061 NA True False NA 287069 NA True False NA 287115 NA True False NA 287155 Stub1 False True Downregulation of TGF-beta receptor signaling;Downregulation of ERBB2 signaling;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation 287156 NA True False Rho GTPase cycle 287191 NA True False NA 287276 NA True False COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Chylomicron assembly;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 287379 NA False True Carnitine synthesis 287417 NA False True Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 287444 NA True False Hypusine synthesis from eIF5A-lysine 287446 NA False True NA 287535 NA False True Retrograde transport at the Trans-Golgi-Network 287633 NA True False NA 287670 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation 287702 NA False True Keratinization;Formation of the cornified envelope 287716 Psme3 False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 287721 NA True False Neutrophil degranulation 287876 NA False True Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Adherens junctions interactions;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;MAP2K and MAPK activation;Clathrin-mediated endocytosis 287877 NA False True NA 287927 NA True False Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;E3 ubiquitin ligases ubiquitinate target proteins;Antigen processing: Ubiquitination & Proteasome degradation 287931 Ppm1f True True NA 287984 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation 287986 NA False True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;mTORC1-mediated signalling;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 288064 NA False True Activation of DNA fragmentation factor 288174 NA True False Neutrophil degranulation 288275 Hunk False True NA 288444 NA True False Regulation of HSF1-mediated heat shock response 288599 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 288620 NA False True Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 288666 NA True False WNT ligand biogenesis and trafficking 288707 NA True False Glycosphingolipid metabolism 288778 NA True False Neutrophil degranulation 288912 NA True False Methionine salvage pathway 289019 NA True False NA 289125 NA True False Mitochondrial Fatty Acid Beta-Oxidation 289144 NA True False NA 289218 NA True False Respiratory electron transport;Complex I biogenesis 289222 NA True False NA 289257 NA False True NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport 289668 NA True False NA 289820 NA True False Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis 289950 NA True False Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism 290029 NA True False Neutrophil degranulation;Purine catabolism 290356 NA True False NA 290364 Itm2b False True NA 290401 NA True False Glutathione conjugation 290408 NA True False The NLRP3 inflammasome 290640 NA True False NA 290641 NA True False NA 290651 NA True False Synthesis of IP2, IP, and Ins in the cytosol 290823 Erlin2 False True ABC-family proteins mediated transport 290868 NA False True NA 290880 NA False True NA 291075 NA True False Beta-oxidation of very long chain fatty acids;Peroxisomal protein import 291081 NA False True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins 291103 NA True False NA 291145 NA False True NA 291152 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 291180 NA True False NA 291394 NA True False Glutathione synthesis and recycling 291434 NA True False NA 291450 NA True False Choline catabolism;Lysine catabolism 291671 Hspa9 False True Regulation of HSF1-mediated heat shock response 291796 NA False True Ub-specific processing proteases 291874 Nup93 False True Transport of Mature mRNA derived from an Intron-Containing Transcript;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of DNA replication proteins 291877 NA False True Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs 291926 NA False True NA 291948 NA True False Neutrophil degranulation 292023 NA True False NA 292072 NA True False Neutrophil degranulation;Purine salvage 292148 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 292156 NA True False NA 292267 NA True False NA 292597 NA True False Stimuli-sensing channels 292732 Numbl True True NA 292804 NA True False Neutrophil degranulation;Glycolysis 292845 NA True False Respiratory electron transport;Protein methylation 292925 Tsg101 True True Endosomal Sorting Complex Required For Transport (ESCRT) 292994 NA False True NA 293448 NA True False NA 293481 NA True False NA 293484 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 293508 NA True False PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;Regulation of insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;VEGFA-VEGFR2 Pathway;CREB1 phosphorylation through the activation of Adenylate Cyclase;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'off' state;CD209 (DC-SIGN) signaling;MAPK6/MAPK4 signaling;HDL assembly;Factors involved in megakaryocyte development and platelet production 293621 Hras True True Activation of RAS in B cells;SHC1 events in ERBB4 signaling;Signaling by SCF-KIT;p38MAPK events;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;Downstream signal transduction;GRB2 events in ERBB2 signaling;Tie2 Signaling;EGFR Transactivation by Gastrin;DAP12 signaling;FCERI mediated MAPK activation;NCAM signaling for neurite out-growth;EPHB-mediated forward signaling;VEGFR2 mediated cell proliferation;CD209 (DC-SIGN) signaling;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Regulation of RAS by GAPs;RAF activation;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative regulation of MAPK pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAS signaling 293684 NA False True NA 293692 NA True False Factors involved in megakaryocyte development and platelet production 293705 Otub1 True True Ub-specific processing proteases;Ovarian tumor domain proteases 293719 NA False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle 293725 NA True False NA 293860 NA False True Platelet degranulation ;GP1b-IX-V activation signalling;Cell-extracellular matrix interactions;RHO GTPases activate PAKs 294010 NA True False MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2 294239 NA True False eNOS activation 294254 NA True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation 294282 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 294292 NA True False Synthesis of pyrophosphates in the cytosol 294320 NA True False Pyruvate metabolism 294326 NA True False NA 294362 NA True False NA 294568 Wasf1 True True Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs 294810 NA True False NA 294864 NA True False NA 294917 NA False True Oxidative Stress Induced Senescence 294930 NA True False LDL clearance 294972 NA False True NA 295230 NA True False Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 295277 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 295347 NA False True ARMS-mediated activation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;MAP2K and MAPK activation;Neutrophil degranulation;MET activates RAP1 and RAC1 295619 NA True False NA 295645 NA True False Bicarbonate transporters 295690 NA False True NA 295929 Mybpc3 False True Striated Muscle Contraction 296131 NA True False NA 296197 NA False True NA 296267 NA True False NA 296318 NA True False NA 296344 NA False True NA 296369 NA False True Striated Muscle Contraction 296480 NA True False NA 296488 NA True False Platelet degranulation 296554 NA True False NA 296570 NA False True NA 296596 NA True False NA 296709 NA True False NA 296710 NA True False NA 296758 NA True False NA 297113 NA False True NA 297428 NA False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 297436 NA True False NA 297518 NA False True Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis 297566 NA True False NA 297593 NA False True Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes 297699 NA True False Downregulation of TGF-beta receptor signaling 297994 Bag1 False True NA 298012 Rad23b True True N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Josephin domain DUBs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER 298079 NA True False NA 298101 NA True False Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;MET activates PTK2 signaling;Collagen chain trimerization 298203 NA True False Processing of SMDT1 298410 NA True False Interconversion of nucleotide di- and triphosphates 298584 NA True False MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Factors involved in megakaryocyte development and platelet production 298596 NA True False Citric acid cycle (TCA cycle) 298609 NA True False NA 298771 NA True False NA 298848 NA True False NA 298917 NA True False NA 298942 NA True False Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Glycine degradation;Pyruvate metabolism;Branched-chain amino acid catabolism;Lysine catabolism 299027 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP 299052 NA False True Platelet degranulation ;Neutrophil degranulation;Gluconeogenesis 299194 NA True False NA 299201 NA True False Glyoxylate metabolism and glycine degradation;Lysine catabolism 299331 Hsp90aa1 True True Signaling by ERBB2;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression 299809 NA True False Association of TriC/CCT with target proteins during biosynthesis;Neutrophil degranulation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 299850 NA True False MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2 299872 NA False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 299923 NA True False NA 299971 NA True False ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 300033 NA True False NA 300079 NA True False NA 300111 NA True False NA 300218 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins 300228 NA False True NA 300247 NA False True Keratinization;Formation of the cornified envelope 300250 NA False True Neutrophil degranulation;Keratinization;Formation of the cornified envelope 300677 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation 300724 NA False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 300726 NA True False Respiratory electron transport 300850 NA True False NA 300968 NA True False Antigen processing: Ubiquitination & Proteasome degradation 300981 NA True False Aflatoxin activation and detoxification 301011 NA True False NA 301252 NA True False Regulation of actin dynamics for phagocytic cup formation;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Sema3A PAK dependent Axon repulsion;Neutrophil degranulation;The NLRP3 inflammasome;The role of GTSE1 in G2/M progression after G2 checkpoint;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression 301384 NA True False Branched-chain amino acid catabolism 301442 Sumo1 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;Regulation of IFNG signaling;Negative regulation of activity of TFAP2 (AP-2) family transcription factors 301458 NA True False Respiratory electron transport;Complex I biogenesis 301555 Cul3 True True Degradation of DVL;Hedgehog 'on' state;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 301618 NA True False NA 302328 NA False True NA 302395 NA False True NA 302500 NA False True NA 302796 NA True False NA 302965 NA False True NA 303222 NA True False Rho GTPase cycle 303306 Srr True True Serine biosynthesis 303634 NA True False NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs) 303831 NA True False ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 304017 NA True False Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases 304469 Rilpl1 False True NA 304542 NA False True NA 304656 NA False True NA 304805 NA True False NA 305021 NA True False Platelet degranulation 305177 NA True False Methionine salvage pathway 305178 NA False True NA 305227 NA True False NA 305288 NA False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 305332 NA False True NA 305457 NA True False NA 305501 NA False True NA 305614 Sptbn1 False True NA 305679 NA True False Platelet degranulation ;Smooth Muscle Contraction;MAP2K and MAPK activation;Neutrophil degranulation 306327 NA False True NA 306332 Ap1m1 True True MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation 306439 NA True False NA 306626 NA False True NA 306840 NA True False NA 306934 NA True False NA 307039 NA True False Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 307309 Sncaip False True NA 307351 NA False True Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins 307503 NA False True Eukaryotic Translation Termination;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 307511 Cdc25c False True Polo-like kinase mediated events;RHO GTPases activate PKNs;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;Cyclin A/B1/B2 associated events during G2/M transition;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 307779 NA True False NA 307821 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation 308100 NA True False NA 308113 NA False True NA 308571 NA True False Receptor-type tyrosine-protein phosphatases 308578 Ap2a1 False True Retrograde neurotrophin signalling;MHC class II antigen presentation;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 308650 NA True False mRNA Splicing - Major Pathway 308690 Ndn False True NA 308709 NA False True NA 308759 NA False True NA 308901 Trim21 False True Regulation of innate immune responses to cytosolic DNA;Antigen processing: Ubiquitination & Proteasome degradation 309168 Map3k11 False True RAF activation 309557 NA False True Neurexins and neuroligins 309774 Gopc False True NA 309901 NA True False NA 310635 NA True False NRAGE signals death through JNK;Rho GTPase cycle 310820 NA True False NA 311020 NA True False NA 311078 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation 311328 NA True False NA 311422 NA True False Purine catabolism 311621 NA True False NA 311671 NA False True NA 311786 Traf2 False True Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;Ub-specific processing proteases;Dimerization of procaspase-8;TNF signaling 311848 NA True False NA 311849 NA False True Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import 311860 Abl1 False True Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;Role of ABL in ROBO-SLIT signaling;RHO GTPases Activate WASPs and WAVEs;HDR through Single Strand Annealing (SSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Cyclin D associated events in G1;RUNX1 regulates transcription of genes involved in differentiation of HSCs 311913 NA False True RAB GEFs exchange GTP for GDP on RABs 312083 NA False True NA 312444 NA True False NA 312694 Necap1 True True Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 312965 Ubxn2b False True NA 313047 NA True False NA 313052 NA False True Neurexins and neuroligins 313200 NA False True NA 313234 NA True False TBC/RABGAPs 313323 NA True False NA 313413 NA True False NA 313474 Eps15 False True NA 313647 NA True False NA 313658 NA True False NA 313867 NA True False NA 313934 NA False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 314140 NA True False 5-Phosphoribose 1-diphosphate biosynthesis 314432 NA True False Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation 314442 NA True False NA 314641 NA True False Synthesis of PIPs at the plasma membrane;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Clathrin-mediated endocytosis 314721 NA True False NA 314764 Eea1 False True NA 314856 Mdm2 False True AKT phosphorylates targets in the cytosol;Oxidative Stress Induced Senescence;Oncogene Induced Senescence;SUMOylation of ubiquitinylation proteins;Trafficking of AMPA receptors;Ub-specific processing proteases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Stabilization of p53;Regulation of RUNX3 expression and activity 314906 NA True False NA 315159 Tob2 False True NA 315265 NA True False NA 315509 NA True False Cell surface interactions at the vascular wall;Integrin cell surface interactions 315608 NA False True Antigen processing: Ubiquitination & Proteasome degradation 315648 NA True False Inhibition of replication initiation of damaged DNA by RB1/E2F1;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;CTLA4 inhibitory signaling;RHO GTPases Activate Formins;RAF activation;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition 315771 NA False True NA 315840 NA False True NA 315989 NA False True NA 316123 NA False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;Estrogen-dependent gene expression 316258 Cd2ap False True NA 316531 NA True False Platelet degranulation ;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Kinesins 316632 NA True False Respiratory electron transport;Complex I biogenesis 316740 NA False True NA 317259 NA True False NA 319177 NA False True NA 319184 NA False True NA 319189 NA False True NA 319190 NA False True NA 319195 NA False True NA 353227 Zbtb16 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 360471 Usp7 True True NA 360504 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma 360543 NA False True NA 360572 NA True False NA 360593 NA True False NA 360643 Cdc27 False True Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation 360678 NA True False Axonal growth inhibition (RHOA activation);Rho GTPase cycle;Axonal growth stimulation 360687 NA True False NA 360820 Pxn False True GAB1 signalosome;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 360853 NA False True UCH proteinases 360854 NA False True Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis 360882 NA True False Adherens junctions interactions;Nectin/Necl trans heterodimerization 360887 NA False True NA 360891 NA False True Signaling by ROBO receptors 360915 NA True False DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation 360921 NA True False NA 360950 NA True False Platelet degranulation 360975 NA True False Glyoxylate metabolism and glycine degradation;Lysine catabolism 361118 NA True False NA 361351 NA True False NA 361370 NA False True Neutrophil degranulation 361388 NA False True NA 361422 NA True False Neutrophil degranulation 361433 NA True False Glycerophospholipid biosynthesis 361503 NA False True NA 361527 NA True False Role of phospholipids in phagocytosis 361532 NA True False NA 361585 NA False True Antigen processing: Ubiquitination & Proteasome degradation 361596 NA True False Transcriptional activation of mitochondrial biogenesis;Citric acid cycle (TCA cycle) 361613 NA True False Cyclin A/B1/B2 associated events during G2/M transition 361663 NA True False Purine ribonucleoside monophosphate biosynthesis 361675 NA True False NA 361677 Tollip True True Neutrophil degranulation;Interleukin-1 signaling 361684 NA True False NA 361791 NA False True NA 361833 NA True False NA 361884 NA False True Biotin transport and metabolism;Branched-chain amino acid catabolism 361967 NA True False ESR-mediated signaling 361970 Trim2 True True NA 362013 NA True False Ion homeostasis 362015 NA True False Purine salvage 362036 Ank2 False True NA 362152 NA True False mRNA Splicing - Major Pathway 362182 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 362245 Map1lc3a True True Macroautophagy;Pink/Parkin Mediated Mitophagy;Receptor Mediated Mitophagy 362332 NA False True Cell-extracellular matrix interactions 362361 NA True False NA 362401 NA False True NA 362440 NA True False Respiratory electron transport;Complex I biogenesis 362479 NA False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation 362587 Macf1 True True NA 362595 NA False True NA 362631 NA True False NA 362634 NA False True Initial triggering of complement;Classical antibody-mediated complement activation;Regulation of Complement cascade 362721 Tssc1 True True NA 362738 NA False True NA 362750 NA True False NA 362809 NA True False Synthesis of Prostaglandins (PG) and Thromboxanes (TX);HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression 362816 NA True False NA 362817 Cdk2 False True G0 and Early G1;Activation of ATR in response to replication stress;Regulation of APC/C activators between G1/S and early anaphase;SCF(Skp2)-mediated degradation of p27/p21;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Processing of DNA double-strand break ends;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Degradation;G2 Phase;Orc1 removal from chromatin;Activation of the pre-replicative complex;CDK-mediated phosphorylation and removal of Cdc6;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates Cell Cycle 362826 Atcay True True NA 362849 March2 False True NA 362855 NA True False NA 362862 Hsp90b1 True True NA 362950 NA True False FGFR2 alternative splicing 362965 Rangap1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Mitotic Prometaphase 362969 NA False True NA 363024 NA True False Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Neutrophil degranulation 363113 NA True False NA 363150 NA False True NA 363465 NA True False Digestion 363644 NA True False NA 363875 Rac1 True True GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;NRAGE signals death through JNK;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;DAP12 signaling;FCERI mediated MAPK activation;DSCAM interactions;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Sema3A PAK dependent Axon repulsion;PCP/CE pathway;Sema4D mediated inhibition of cell attachment and migration;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;Signal transduction by L1;VEGFR2 mediated vascular permeability;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate NADPH Oxidases;MAPK6/MAPK4 signaling;Neutrophil degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;NTRK2 activates RAC1;Factors involved in megakaryocyte development and platelet production 363925 NA False True NA 363972 NA True False NA 364052 NA True False RAF-independent MAPK1/3 activation;RAF/MAP kinase cascade 364208 NA True False NA 364694 NA False True NA 364716 NA False True NA 364723 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 364838 NA True False Olfactory Signaling Pathway 365216 NA True False NA 365377 NA False True Smooth Muscle Contraction 365388 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Neddylation 365877 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 366189 NA False True NA 366448 NA False True NA 366568 NA True False NA 367171 NA True False NA 369016 NA True False NA 369017 NA False True NA 382522 NA False True NA 397785 NA False True NA 398985 NA False True NA 403728 NA False True NA 404093 NA False True NA 406167 NA True False NA 408248 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 432508 NA False True NA 445442 NA False True NA 450225 NA False True Keratinization;Formation of the cornified envelope 493810 NA True False MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Advanced glycosylation endproduct receptor signaling;Factors involved in megakaryocyte development and platelet production 494445 NA True False Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing 497198 NA True False NA 497794 NA True False NA 497902 NA True False NA 498174 NA False True NA 498407 NA True False NA 498433 NA False True UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 498736 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins 498909 NA True False NA 499417 Sumo3 False True SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription cofactors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of DNA replication proteins;SUMOylation of immune response proteins;Formation of Incision Complex in GG-NER 499529 NA True False Respiratory electron transport;Complex I biogenesis 499558 March11 False True NA 499782 NA True False NA 499913 NA True False Arachidonate production from DAG 500105 Cntnap2 False True NA 500282 NA True False NA 500351 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 500377 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins 500419 NA False True NA 500450 NA False True Striated Muscle Contraction;Smooth Muscle Contraction 500929 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins 500985 Cbl False True Interleukin-6 signaling;Spry regulation of FGF signaling;Regulation of KIT signaling;EGFR downregulation;TGF-beta receptor signaling activates SMADs;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Negative regulation of MET activity;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Regulation of signaling by CBL 501083 NA True False NA 501621 NA False True Transport of Mature mRNA derived from an Intron-Containing Transcript 501625 NA False True NA 502125 NA True False NA 502674 NA True False NA 502776 NA True False NA 502913 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 513971 NA False True NA 613226 NA True False NA 617095 NA False True NA 618164 NA False True NA 619561 NA False True Mitochondrial Fatty Acid Beta-Oxidation 641434 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation 678759 NA True False Respiratory electron transport;Complex I biogenesis 679221 NA True False NA 680102 NA False True NA 680423 NA False True NA 680522 NA False True NA 681896 NA True False Organic anion transporters 682507 Wasl False True Regulation of actin dynamics for phagocytic cup formation;NOSTRIN mediated eNOS trafficking;Nephrin family interactions;EPHB-mediated forward signaling;DCC mediated attractive signaling;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis 683313 NA False True NA 683788 NA True False NA 684097 NA True False NA 684988 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 685859 NA False True NA 686098 Sorbs1 False True NA 687008 NA True False NA 687090 NA True False NA 687506 NA False True NA 688288 NA True False Cleavage of Growing Transcript in the Termination Region ;ISG15 antiviral mechanism;Transport of Mature mRNA derived from an Intron-Containing Transcript;Deadenylation of mRNA;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 688386 NA True False NA 689064 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation 689560 Ryr2 True True NA 689852 NA False True Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 690131 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 690163 NA True False Utilization of Ketone Bodies 690244 NA False True NA 690441 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation 690660 NA True False NA 690795 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 690987 NA False True Glycogen synthesis 691149 NA True False NA 691974 NA False True NA 824261 NA False True NA 852088 NA False True NA 852107 NA False True NA 853358 NA False True NA 100134871 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation 100145871 NA True False Ethanol oxidation 100359951 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 100359982 NA True False NA 100360117 NA True False NA 100360180 NA True False NA 100360501 NA True False NA 100360508 NA True False NA 100360679 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 100360846 NA True False Autodegradation of Cdh1 by Cdh1:APC/C;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Neddylation 100360977 NA True False NA 100361558 NA True False PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production 100361891 NA True False NA 100361915 NA False True NA 100362149 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 100362640 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 100362684 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 100362830 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 100363439 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 100363502 NA True False NA 100364335 NA True False NA 100365810 NA True False NA 100909441 NA True False Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Kinesins 100909595 NA True False Cellular hexose transport;Vitamin C (ascorbate) metabolism;Neutrophil degranulation 100909840 NA True False Signaling by ROBO receptors;RHO GTPases Activate Formins 100911186 NA True False Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 100911372 NA True False NA 100911402 NA True False NA 100911417 NA True False Formation of ATP by chemiosmotic coupling;Cristae formation 100911625 NA True False Gluconeogenesis 100912489 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 100912564 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 102555453 NA True False NA 103689947 NA True False NA 103689983 NA True False Purine salvage 103689992 NA True False L13a-mediated translational silencing of Ceruloplasmin expression;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 103689999 NA True False Platelet degranulation 103690002 NA True False PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression 103690190 NA True False NA 103692716 NA True False Signaling by ERBB2;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression 103693564 NA True False NA 103693780 NA True False Glyoxylate metabolism and glycine degradation;Lysine catabolism 103694857 NA True False Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation 103694877 NA True False Cell surface interactions at the vascular wall;Neutrophil degranulation 103694903 NA True False Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;CTLA4 inhibitory signaling;RHO GTPases Activate Formins;RAF activation;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 108348061 NA True False NA 108348073 NA True False Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 108348108 NA True False Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation 108348115 NA True False NA 108348142 NA True False NA 108348148 NA True False Glutathione conjugation 108348161 NA True False NA 108351137 NA True False NA NA NA True False NA