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"planemo upload commit c9a32e920aae2bc186183611bc0abb2040e106f3"
author proteore
date Thu, 06 Feb 2020 08:28:04 -0500
parents 99f6a94c1ade
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"-"], ["99890", "64960", "Prmt6", "MRPS15", "Affinity Capture-MS", "physical", "26496610", "-", "-"], ["99890", "84458", "Prmt6", "LCOR", "Affinity Capture-MS", "physical", "26496610", "-", "-"], ["99890", "284217", "Prmt6", "LAMA1", "Affinity Capture-MS", "physical", "26496610", "-", "-"]], "99982": [["99982", "71950", "Kdm1a", "Nanog", "Affinity Capture-Western", "physical", "18454139", "-", "-"], ["99982", "11835", "Kdm1a", "Ar", "Affinity Capture-Western", "physical", "16079795", "-", "-"], ["99982", "11835", "Kdm1a", "Ar", "Co-localization", "physical", "16079795", "-", "-"], ["99982", "76804", "Kdm1a", "Kdm4c", "Affinity Capture-Western", "physical", "17277772", "-", "-"], ["99982", "76804", "Kdm1a", "Kdm4c", "Co-purification", "physical", "17277772", "-", "-"], ["99982", "11835", "Kdm1a", "Ar", "Co-purification", "physical", "17277772", "-", "-"], ["99982", "76804", "Kdm1a", "Kdm4c", "Reconstituted Complex", "physical", "17277772", "-", "-"], ["99982", "17261", "Kdm1a", "Mef2d", "Affinity Capture-Western", "physical", "20833138", "-", "-"], ["99982", "17927", "Kdm1a", "Myod1", "Affinity Capture-Western", "physical", "20833138", "-", "-"], ["99982", "27221", "Kdm1a", "Chaf1a", "Affinity Capture-Western", "physical", "26365490", "-", "-"]], "Entrez Gene Interactor A": [["Entrez Gene Interactor A", "Entrez Gene Interactor B", "Official Symbol Interactor A", "Official Symbol Interactor B", "Experimental System", "Experimental System Type", "Pubmed ID", "Score", "Phenotypes"]]}, "nodes": {"100009614": ["Keratinization"], "100017": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Chylomicron clearance", "LDL clearance"], "100034361": ["Molecules associated with elastic fibres"], "100034684": ["Formation of the cornified envelope"], "100037258": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "100037283": ["Neutrophil degranulation"], "100038854": ["Formation of the cornified envelope"], "100038882": ["ISG15 antiviral mechanism", "Termination of translesion DNA synthesis"], "100038947": ["Cell surface interactions at the vascular wall", "DAP12 interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "100038993": ["IL-6-type cytokine receptor ligand interactions"], "100039053": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100039319": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "100039707": ["Metabolism of folate and pterines"], "100039863": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100039939": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100040048": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100040233": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "100040248": ["Keratinization"], "100040276": ["Keratinization"], "100040299": ["Keratinization"], "100040462": ["Neutrophil degranulation"], "100040531": ["Neutrophil degranulation"], "100040563": ["Neutrophil degranulation"], "100040608": ["Fanconi Anemia Pathway"], "100040843": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "100041085": ["Cellular hexose transport"], "100041230": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "100041250": ["Keratinization"], "100041261": ["Keratinization"], "100041273": ["Respiratory electron transport", "Complex I biogenesis"], "100041281": ["Keratinization"], "100041351": ["Keratinization"], "100041375": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "100041412": ["Keratinization"], "100041449": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "100041488": ["Keratinization"], "100041504": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100041581": ["Generic Transcription Pathway"], "100041585": ["Metabolism of polyamines"], "100041586": ["Intraflagellar transport"], "100041593": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100041639": ["Intraflagellar transport"], "100041953": ["HDACs deacetylate histones"], "100042150": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "100042165": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "100042295": ["Glutathione conjugation"], "100042314": ["Glutathione conjugation"], "100042493": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100042503": ["Respiratory electron transport", "Complex I biogenesis"], "100042555": ["IL-6-type cytokine receptor ligand interactions"], "100042690": ["Olfactory Signaling Pathway"], "100042761": ["Hedgehog 'on' state"], "100042807": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "100043039": ["XBP1(S) activates chaperone genes"], "100043108": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "100043123": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "100043125": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "100043188": ["Hedgehog 'on' state"], "100043254": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (s) signalling events"], "100043456": ["Mineralocorticoid biosynthesis"], "100043461": ["Mineralocorticoid biosynthesis"], "100043507": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "100043684": ["Digestion of dietary carbohydrate"], "100043686": ["Digestion of dietary carbohydrate"], "100043688": ["Digestion of dietary carbohydrate"], "100043771": ["Josephin domain DUBs"], "100043813": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "L13a-mediated translational silencing of Ceruloplasmin expression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Major pathway of rRNA processing in the nucleolus and cytosol", "Mitotic Prometaphase", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "100066": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "100073351": ["ATF6 (ATF6-alpha) activates chaperones"], "100102": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "VLDLR internalisation and degradation", "Post-translational protein phosphorylation", "LDL clearance"], "100126226": ["Keratinization", "Formation of the cornified envelope"], "100163": ["Platelet homeostasis"], "100191037": ["Keratinization"], "100206": ["POLB-Dependent Long Patch Base Excision Repair"], "100216474": ["Carboxyterminal post-translational modifications of tubulin"], "100273": ["Synthesis of bile acids and bile salts"], "100310872": ["Neutrophil degranulation"], "100328588": ["Phenylalanine and tyrosine catabolism"], "100415785": ["Keratinization"], "100416706": ["Generic Transcription Pathway"], "100417514": ["Ethanol oxidation"], "100434": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds", "Choline catabolism"], "100502766": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "100502803": ["Keratinization"], "100502831": ["Keratinization"], "100502865": ["Keratinization"], "100502876": ["Ca2+ activated K+ channels"], "100502887": ["Olfactory Signaling Pathway"], "100502921": ["Keratinization"], "100502953": ["Keratinization"], "100503085": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "100503388": ["Keratinization"], "100503486": ["Olfactory Signaling Pathway"], "100503605": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma", "Neutrophil degranulation"], "100504183": ["Keratinization"], "100504239": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100504346": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100504362": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100504663": ["Macroautophagy"], "100529082": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "100559": ["Glucuronidation"], "100561": ["Proton/oligopeptide cotransporters", "Neutrophil degranulation"], "100604": ["Miscellaneous transport and binding events"], "100608": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "100678": ["Serine biosynthesis"], "100683": ["Formation of the beta-catenin:TCF transactivating complex", "Ub-specific processing proteases"], "100689": ["O-glycosylation of TSR domain-containing proteins"], "100705": ["ChREBP activates metabolic gene expression", "Biotin transport and metabolism", "Import of palmitoyl-CoA into the mitochondrial matrix"], "100710": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "100727": ["Glucuronidation"], "100737": ["Neddylation"], "100756": ["Ub-specific processing proteases"], "100763": ["Antigen processing: Ubiquitination & Proteasome degradation"], "100855": ["TBC/RABGAPs"], "100861978": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100862175": ["Pre-NOTCH Processing in Golgi", "COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "100862177": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100862375": ["Phosphate bond hydrolysis by NTPDase proteins"], "100862446": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Iron uptake and transport"], "100862468": ["Major pathway of rRNA processing in the nucleolus and cytosol", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "100900": ["Mitochondrial protein import", "Mitochondrial iron-sulfur cluster biogenesis"], "100910": ["Chondroitin sulfate biosynthesis"], "100952": ["Molecules associated with elastic fibres"], "100986": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Phase 3 - rapid repolarisation", "Phase 2 - plateau phase", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "101055671": ["Formation of the cornified envelope"], "101095": ["Generic Transcription Pathway"], "101100": ["Carboxyterminal post-translational modifications of tubulin"], "101185": ["DNA Damage/Telomere Stress Induced Senescence"], "101206": ["Ub-specific processing proteases"], "101314": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "101358": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "101401": ["O-glycosylation of TSR domain-containing proteins"], "101476": ["Synthesis of PIPs at the plasma membrane"], "101488": ["Transport of organic anions"], "101488143": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma", "Neutrophil degranulation"], "101490": ["Synthesis of PIPs at the early endosome membrane"], "101497": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "101502": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "101540": ["Sphingolipid de novo biosynthesis"], "101543": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "101565": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Ub-specific processing proteases", "AURKA Activation by TPX2"], "101568": ["ERKs are inactivated"], "101604": ["Generic Transcription Pathway"], "101706": ["Recruitment of NuMA to mitotic centrosomes", "Mitotic Prophase"], "101772": ["Stimuli-sensing channels"], "101809": ["Regulation of RAS by GAPs"], "101831": ["Fanconi Anemia Pathway"], "101861": ["RNA polymerase II transcribes snRNA genes"], "101867": ["SIRT1 negatively regulates rRNA expression"], "101943": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "102022": ["Phase I - Functionalization of compounds"], "102058": ["Insulin processing", "VxPx cargo-targeting to cilium"], "102060": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "102093": ["Glycogen breakdown (glycogenolysis)"], "102098": ["NRAGE signals death through JNK", "Rho GTPase cycle", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "102115": ["Hypusine synthesis from eIF5A-lysine"], "102209": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "102216272": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "102247": ["Synthesis of PA"], "102278": ["Glycerophospholipid biosynthesis"], "102294": ["Endogenous sterols", "The canonical retinoid cycle in rods (twilight vision)"], "102323": ["Neddylation"], "102339": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "102442": ["RAB GEFs exchange GTP for GDP on RABs"], "102448": ["Formation of xylulose-5-phosphate"], "102462": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "102566": ["Stimuli-sensing channels"], "102570": ["Nicotinamide salvaging"], "102580": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "102595": ["Neutrophil degranulation"], "102614": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "102626": ["p38MAPK events", "Oxidative Stress Induced Senescence", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation"], "102632": ["Mitochondrial Fatty Acid Beta-Oxidation"], "102636558": ["SUMOylation of DNA damage response and repair proteins"], "102637269": ["XBP1(S) activates chaperone genes"], "102637366": ["Generic Transcription Pathway"], "102639995": ["Keratinization"], "102640500": ["Keratinization"], "102680": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "102774": ["BBSome-mediated cargo-targeting to cilium"], "102857": ["Creatine metabolism"], "102920": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "102954": ["Synthesis of pyrophosphates in the cytosol"], "103098": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "103135": ["Deadenylation of mRNA"], "103142": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "103149": ["Pyrimidine catabolism"], "103199": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "103236": ["Sphingolipid de novo biosynthesis"], "103468": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "103534": ["N-Glycan antennae elongation"], "103554": ["UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "103573": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Deactivation of the beta-catenin transactivating complex", "HuR (ELAVL1) binds and stabilizes mRNA", "RHO GTPases Activate Formins", "MAPK6/MAPK4 signaling", "Mitotic Prometaphase", "Cyclin A/B1/B2 associated events during G2/M transition"], "103583": ["Activation of NF-kappaB in B cells", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "103677": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "103711": ["Vitamins B6 activation to pyridoxal phosphate"], "103724": ["TBC/RABGAPs"], "103733": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "103737": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "103768": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "103806": ["NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling"], "103836": ["Generic Transcription Pathway"], "103850": ["Pyrimidine catabolism"], "103964": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "103967": ["Toll Like Receptor 4 (TLR4) Cascade", "MHC class II antigen presentation", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "103978": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Release of Hh-Np from the secreting cell", "Retinoid metabolism and transport"], "103988": ["Regulation of Glucokinase by Glucokinase Regulatory Protein", "Glycolysis"], "104002": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "104009": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "104015": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Clathrin-mediated endocytosis"], "104086": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "104099": ["Integrin cell surface interactions", "ECM proteoglycans", "Signal transduction by L1"], "104110": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "104111": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "104112": ["ChREBP activates metabolic gene expression", "Neutrophil degranulation", "Fatty acyl-CoA biosynthesis"], "104130": ["Respiratory electron transport", "Complex I biogenesis"], "104158": ["Metabolism of Angiotensinogen to Angiotensins", "Phase I - Functionalization of compounds"], "104174": ["Glycine degradation"], "104183": ["Digestion of dietary carbohydrate"], "104184": ["Antigen processing: Ubiquitination & Proteasome degradation"], "104215": ["Rho GTPase cycle", "RHO GTPases regulate CFTR trafficking"], "104245": ["Na+/Cl- dependent neurotransmitter transporters"], "104248": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "104252": ["MAPK6/MAPK4 signaling"], "104263": ["HDMs demethylate histones"], "104303": ["Retrograde transport at the Trans-Golgi-Network"], "104318": ["COPII-mediated vesicle transport", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Major pathway of rRNA processing in the nucleolus and cytosol", "AURKA Activation by TPX2"], "104346": ["Activation of SMO"], "104394": ["G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Cyclin D associated events in G1"], "104416": ["UCH proteinases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "104418": ["Effects of PIP2 hydrolysis"], "104443": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "104625": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "104662": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "104709": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma"], "104725": ["Sphingolipid de novo biosynthesis"], "104759": ["Synthesis of IP3 and IP4 in the cytosol", "Role of phospholipids in phagocytosis"], "104776": ["Branched-chain amino acid catabolism"], "104806": ["Fanconi Anemia Pathway"], "104816": ["Amino acid synthesis and interconversion (transamination)"], "104884": ["Nonhomologous End-Joining (NHEJ)"], "104886": ["RAB geranylgeranylation"], "104923": ["Methionine salvage pathway"], "105014": ["RA biosynthesis pathway"], "105193": ["Glycogen synthesis"], "105243": ["Sodium/Proton exchangers"], "105245": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation"], "105348": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "105349": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "105355": ["Stimuli-sensing channels"], "105372": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "105387": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "105445": ["Factors involved in megakaryocyte development and platelet production"], "105446": ["Purine salvage"], "105501": ["Acyl chain remodelling of PE"], "105504": ["Insulin processing", "VxPx cargo-targeting to cilium"], "105513": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "105522": ["COPII-mediated vesicle transport"], "105638": ["Synthesis of diphthamide-EEF2"], "105663": ["Vitamin B1 (thiamin) metabolism"], "105722": ["Stimuli-sensing channels", "Neutrophil degranulation"], "105727": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Amino acid transport across the plasma membrane"], "105785": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "105787": ["Macroautophagy", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "105841": ["RAB GEFs exchange GTP for GDP on RABs"], "105847": ["Assembly of active LPL and LIPC lipase complexes"], "105855": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation"], "105866": ["Keratinization", "Formation of the cornified envelope"], "105886299": ["Chylomicron assembly", "Chylomicron remodeling", "HDL remodeling", "Retinoid metabolism and transport"], "105887": ["Glucuronidation"], "105988": ["Separation of Sister Chromatids"], "106021": ["SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins"], "106025": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "106042": ["Asymmetric localization of PCP proteins"], "106052": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "106298": ["RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape"], "106344": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "106389": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "106512": ["G alpha (i) signalling events"], "106529": ["Synthesis of very long-chain fatty acyl-CoAs"], "106557": ["Pyruvate metabolism"], "106564": ["Coenzyme A biosynthesis"], "106572": ["Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "106628": ["Rho GTPase cycle", "Clathrin-mediated endocytosis"], "106633": ["Hedgehog 'off' state", "Intraflagellar transport"], "106722": ["GPVI-mediated activation cascade"], "106757": ["Sperm Motility And Taxes"], "106759": ["Caspase activation via Death Receptors in the presence of ligand", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "106766": ["PTK6 Activates STAT3"], "106840": ["Trafficking of myristoylated proteins to the cilium"], "106861": ["Synthesis of PC"], "106869": ["PI Metabolism"], "106931": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "106947": ["Zinc influx into cells by the SLC39 gene family"], "106952": ["Rho GTPase cycle"], "106957": ["Zinc influx into cells by the SLC39 gene family"], "107029": ["Citric acid cycle (TCA cycle)"], "107065": ["Neurexins and neuroligins"], "107146": ["Conjugation of benzoate with glycine"], "107221": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events"], "107239": ["Histidine catabolism"], "107260": ["Ub-specific processing proteases", "Ovarian tumor domain proteases"], "107272": ["Serine biosynthesis"], "107305": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "107338": ["Clathrin derived vesicle budding", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "107371": ["Insulin processing", "VxPx cargo-targeting to cilium"], "107392": ["HDACs deacetylate histones"], "107435": ["HATs acetylate histones"], "107448": ["Netrin-1 signaling"], "107476": ["ChREBP activates metabolic gene expression", "Biotin transport and metabolism", "Import of palmitoyl-CoA into the mitochondrial matrix", "Fatty acyl-CoA biosynthesis"], "107477": ["Inactivation, recovery and regulation of the phototransduction cascade"], "107515": ["Regulation of FZD by ubiquitination"], "107522": ["Peptide ligand-binding receptors"], "107527": ["Interleukin-38 signaling", "Interleukin-36 pathway"], "107568": ["Downregulation of ERBB4 signaling", "Stimuli-sensing channels", "Antigen processing: Ubiquitination & Proteasome degradation"], "107569": ["Pyrimidine catabolism"], "107581": ["Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions", "Collagen chain trimerization"], "107585": ["Regulation of thyroid hormone activity"], "107589": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs"], "107605": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "107607": ["NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "107626": ["Serotonin and melatonin biosynthesis"], "107650": ["Synthesis of PIPs at the Golgi membrane"], "107652": ["Synthesis of UDP-N-acetyl-glucosamine"], "107656": ["Keratinization", "Formation of the cornified envelope"], "107686": ["snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "107701": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "107723": ["Cation-coupled Chloride cotransporters"], "107732": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "107733": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "107734": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "107746": ["Frs2-mediated activation", "Downstream signal transduction", "MET activates RAP1 and RAC1", "Erythropoietin activates RAS", "Regulation of signaling by CBL"], "107747": ["Metabolism of folate and pterines"], "107766": ["Tryptophan catabolism"], "107767": ["Neutrophil degranulation"], "107771": ["Ub-specific processing proteases", "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "Estrogen-dependent gene expression"], "107817": ["HDMs demethylate histones"], "107823": ["PKMTs methylate histone lysines", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "107829": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "107869": ["Degradation of cysteine and homocysteine", "Cysteine formation from homocysteine"], "107885": ["Metabolism of folate and pterines"], "107895": ["N-Glycan antennae elongation"], "107932": ["HDACs deacetylate histones", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "107939": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "107951": ["Formation of RNA Pol II elongation complex ", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation", "Estrogen-dependent gene expression"], "107971": ["FRS-mediated FGFR1 signaling", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "RAF/MAP kinase cascade"], "107976": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "107986": ["Ub-specific processing proteases", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Neddylation"], "107995": ["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "APC/C:Cdc20 mediated degradation of Cyclin B", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of Emi1", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Ub-specific processing proteases", "Mitotic Prometaphase", "Antigen processing: Ubiquitination & Proteasome degradation"], "108000": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "108011": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "108012": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "108014": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "108015": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors", "Neutrophil degranulation"], "108017": ["Ion homeostasis", "Ion transport by P-type ATPases"], "108030": ["Dopamine Neurotransmitter Release Cycle"], "108037": ["Metabolism of folate and pterines"], "108043": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "108052": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "108058": ["HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Interferon gamma signaling", "Ion transport by P-type ATPases"], "108062": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "108067": ["Recycling of eIF2:GDP"], "108068": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "108069": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "108071": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "Neurexins and neuroligins"], "108072": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "108073": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "108075": ["Molecules associated with elastic fibres"], "108077": ["mRNA decay by 3' to 5' exoribonuclease"], "108078": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "108079": ["Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "108083": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "108096": ["Recycling of bile acids and salts", "Transport of organic anions"], "108097": ["Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "108099": ["Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "108100": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "108101": ["Platelet degranulation "], "108105": ["O-linked glycosylation of mucins"], "108114": ["Organic anion transport"], "108115": ["Transport of organic anions"], "108116": ["Transport of organic anions"], "108123": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "108124": ["COPII-mediated vesicle transport", "Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "108138": ["SUMOylation of DNA damage response and repair proteins", "Nonhomologous End-Joining (NHEJ)"], "108143": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "108147": ["Purine ribonucleoside monophosphate biosynthesis"], "108148": ["COPI-independent Golgi-to-ER retrograde traffic", "O-linked glycosylation of mucins"], "108150": ["O-linked glycosylation of mucins"], "108153": ["O-glycosylation of TSR domain-containing proteins"], "108154": ["O-glycosylation of TSR domain-containing proteins"], "108155": ["HATs acetylate histones", "UCH proteinases"], "108156": ["Metabolism of folate and pterines"], "108645": ["Methylation", "Ub-specific processing proteases"], "108652": ["Transport and synthesis of PAPS", "Transport of nucleotide sugars"], "108653": ["Amino acid synthesis and interconversion (transamination)"], "108664": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "108679": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "108682": ["Amino acid synthesis and interconversion (transamination)"], "108699": ["Rho GTPase cycle"], "108723": ["Activation of NF-kappaB in B cells", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling"], "108760": ["O-linked glycosylation of mucins"], "108800": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "108829": ["Factors involved in megakaryocyte development and platelet production"], "108841": ["RA biosynthesis pathway"], "108853": ["Mitochondrial translation termination"], "108888": ["Neutrophil degranulation"], "108902": ["Keratan sulfate biosynthesis", "O-linked glycosylation"], "108911": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "108956": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "108958": ["Synthesis of PA"], "108960": ["NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "108961": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "108989": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "108995": ["Neutrophil degranulation", "TBC/RABGAPs"], "109019": ["RNA polymerase II transcribes snRNA genes"], "109052": ["Keratinization", "Formation of the cornified envelope"], "109075": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "109077": ["RNA polymerase II transcribes snRNA genes"], "109113": ["SUMOylation of transcription cofactors"], "109129": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "109135": ["Synthesis of PIPs at the plasma membrane"], "109136": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Propionyl-CoA catabolism"], "109145": ["Unwinding of DNA"], "109151": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "109154": ["Neutrophil degranulation"], "109161": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "109181": ["Intraflagellar transport", "Intra-Golgi traffic"], "109232": ["Platelet degranulation "], "109241": ["UCH proteinases"], "109242": ["Anchoring of the basal body to the plasma membrane"], "109264": ["Citric acid cycle (TCA cycle)"], "109270": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "109272": ["Striated Muscle Contraction"], "109275": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "109294": ["Regulation of PTEN stability and activity"], "109331": ["E3 ubiquitin ligases ubiquitinate target proteins"], "109333": ["RHO GTPases activate PKNs"], "109342": ["Cellular hexose transport"], "109359": ["Metalloprotease DUBs"], "109552": ["Stimuli-sensing channels", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis", "Ion transport by P-type ATPases"], "109594": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "109620": ["Apoptotic cleavage of cell adhesion  proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "109624": ["Smooth Muscle Contraction"], "109648": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "109652": ["Aflatoxin activation and detoxification"], "109658": ["Other interleukin signaling"], "109672": ["Vitamin C (ascorbate) metabolism"], "109674": ["Purine salvage"], "109676": ["Interaction between L1 and Ankyrins", "COPI-mediated anterograde transport"], "109685": ["CS/DS degradation"], "109689": ["G alpha (s) signalling events", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Thrombin signalling through proteinase activated receptors (PARs)", "Activation of SMO", "MAP2K and MAPK activation", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "109700": ["Integrin cell surface interactions", "Smooth Muscle Contraction"], "109711": ["Platelet degranulation ", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "109731": ["Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "109754": ["Vitamin C (ascorbate) metabolism", "Phase I - Functionalization of compounds", "Neutrophil degranulation"], "109778": ["Heme degradation"], "109785": ["Synthesis of UDP-N-acetyl-glucosamine"], "109791": ["Digestion of dietary lipid", "Retinoid metabolism and transport"], "109801": ["Pyruvate metabolism"], "109821": ["Intrinsic Pathway of Fibrin Clot Formation"], "109828": ["Terminal pathway of complement", "Regulation of Complement cascade"], "109857": ["Phase I - Functionalization of compounds"], "109880": ["Spry regulation of FGF signaling", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway"], "109904": ["Axonal growth inhibition (RHOA activation)", "NRAGE signals death through JNK", "Rho GTPase cycle"], "109905": ["ARMS-mediated activation", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "MAP2K and MAPK activation", "Neutrophil degranulation", "MET activates RAP1 and RAC1"], "109934": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "109959": ["Digestion of dietary carbohydrate"], "109978": ["Post-translational modification: synthesis of GPI-anchored proteins"], "109979": ["Post-translational modification: synthesis of GPI-anchored proteins"], "110006": ["HS-GAG degradation", "Neutrophil degranulation"], "110033": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "110052": ["B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"], "110074": ["Interconversion of nucleotide di- and triphosphates"], "110078": ["Neutrophil degranulation"], "110094": ["Glycogen breakdown (glycogenolysis)"], "110095": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "110115": ["Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis", "Endogenous sterols"], "110119": ["Synthesis of GDP-mannose"], "110135": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "MAP2K and MAPK activation", "Regulation of TLR by endogenous ligand"], "110147": ["Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation", "RNA Polymerase I Transcription Initiation", "Transcriptional Regulation by E2F6"], "110157": ["Stimuli-sensing channels", "Rap1 signalling", "GP1b-IX-V activation signalling", "CD209 (DC-SIGN) signaling", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway"], "110168": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "110173": ["Neutrophil degranulation", "Lysosomal oligosaccharide catabolism"], "110175": ["Glutathione synthesis and recycling"], "110196": ["Cholesterol biosynthesis"], "110197": ["Effects of PIP2 hydrolysis"], "110198": ["Aflatoxin activation and detoxification"], "110208": ["Pentose phosphate pathway"], "110257": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma"], "110265": ["Protein repair"], "110279": ["Rho GTPase cycle"], "110304": ["Neurotransmitter receptors and postsynaptic signal transmission"], "110308": ["Type I hemidesmosome assembly", "Keratinization", "Formation of the cornified envelope"], "110310": ["Keratinization", "Formation of the cornified envelope"], "110312": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "110326": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "110351": ["Rap1 signalling", "RET signaling"], "110355": ["Calmodulin induced events", "G alpha (q) signalling events", "G alpha (s) signalling events", "Activation of SMO", "Cargo recognition for clathrin-mediated endocytosis"], "110379": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "110382": ["Terminal pathway of complement", "Regulation of Complement cascade"], "110385": ["DARPP-32 events", "G alpha (s) signalling events"], "110391": ["Phenylalanine and tyrosine catabolism"], "110417": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "110446": ["Branched-chain amino acid catabolism"], "110460": ["Cholesterol biosynthesis"], "110511": ["Olfactory Signaling Pathway"], "110524": ["Effects of PIP2 hydrolysis"], "110532": ["C6 deamination of adenosine", "Formation of editosomes by ADAR proteins"], "110542": ["Signaling by BMP"], "110557": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "110596": ["EPHB-mediated forward signaling"], "110599584": ["Peptide ligand-binding receptors"], "110606": ["Inactivation, recovery and regulation of the phototransduction cascade"], "110611": ["HDL clearance"], "110616": ["Josephin domain DUBs", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "110637": ["Activation of Ca-permeable Kainate Receptor"], "110639": ["5-Phosphoribose 1-diphosphate biosynthesis"], "110651": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "110695": ["Choline catabolism", "Lysine catabolism"], "110784": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "110809": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "110816": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "110821": ["Biotin transport and metabolism", "Propionyl-CoA catabolism"], "110826": ["Respiratory electron transport", "Protein methylation"], "110829": ["Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "110834": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "110835": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "110842": ["Respiratory electron transport"], "110862": ["Voltage gated Potassium channels"], "110876": ["Phase 0 - rapid depolarisation"], "110877": ["Na+/Cl- dependent neurotransmitter transporters"], "110880": ["Phase 0 - rapid depolarisation"], "110886": ["GABA A receptor activation"], "110891": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis"], "110893": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis"], "110895": ["Sodium/Proton exchangers"], "110902": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "110911": ["Synthesis of PG"], "110920": ["Regulation of HSF1-mediated heat shock response"], "110935": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "110948": ["Biotin transport and metabolism"], "110959": ["Peroxisomal lipid metabolism", "Peroxisomal protein import"], "110962": ["UCH proteinases"], "111174": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "111175": ["Alpha-oxidation of phytanate", "Peroxisomal protein import"], "111241": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "111368": ["Post-translational modification: synthesis of GPI-anchored proteins"], "112405": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "112406": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "112407": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "112408": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "112417": ["Glucuronidation"], "11298": ["Serotonin and melatonin biosynthesis"], "11303": ["HDL assembly"], "11304": ["The canonical retinoid cycle in rods (twilight vision)", "ABC-family proteins mediated transport"], "11305": ["ABC transporters in lipid homeostasis"], "11306": ["Mitochondrial ABC transporters"], "11307": ["ABC transporters in lipid homeostasis", "HDL remodeling"], "11308": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "11350": ["Regulation of actin dynamics for phagocytic cup formation", "CDO in myogenesis", "Role of ABL in ROBO-SLIT signaling", "RHO GTPases Activate WASPs and WAVEs", "HDR through Single Strand Annealing (SSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Cyclin D associated events in G1", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "11352": ["Role of ABL in ROBO-SLIT signaling"], "11363": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "11364": ["Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "11370": ["Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "113868": ["alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids", "Neutrophil degranulation", "Peroxisomal protein import"], "11409": ["Beta oxidation of butanoyl-CoA to acetyl-CoA"], "114143": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "11416": ["Transport of vitamins, nucleosides, and related molecules"], "11418": ["Stimuli-sensing channels"], "11419": ["Stimuli-sensing channels"], "11421": ["Metabolism of Angiotensinogen to Angiotensins"], "114228": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "114229": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "11423": ["Neurotransmitter clearance", "Synthesis of PC", "Synthesis, secretion, and deacylation of Ghrelin"], "11425": ["VLDL assembly", "VLDL clearance"], "114255": ["RET signaling"], "11428": ["Iron uptake and transport"], "11429": ["Citric acid cycle (TCA cycle)"], "11430": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "114304": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "11433": ["Vitamin B2 (riboflavin) metabolism"], "114332": ["Hyaluronan uptake and degradation"], "11434": ["Acrosome Reaction"], "11435": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "11438": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "11440": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "11441": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "11444": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "11447": ["Highly sodium permeable acetylcholine nicotinic receptors"], "114479": ["Thyroxine biosynthesis", "Organic anion transporters"], "11448": ["Highly sodium permeable acetylcholine nicotinic receptors"], "11449": ["Highly sodium permeable acetylcholine nicotinic receptors"], "11450": ["AMPK inhibits chREBP transcriptional activation activity"], "114566": ["Keratinization", "Formation of the cornified envelope"], "11459": ["Striated Muscle Contraction"], "11461": ["Gap junction degradation", "Formation of annular gap junctions", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "Adherens junctions interactions", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "Interaction between L1 and Ankyrins", "Cell-extracellular matrix interactions", "B-WICH complex positively regulates rRNA expression", "RHO GTPases activate IQGAPs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "MAP2K and MAPK activation", "UCH proteinases", "DNA Damage Recognition in GG-NER", "Clathrin-mediated endocytosis"], "11464": ["Striated Muscle Contraction"], "114640": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "114644": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "11465": ["Gap junction degradation", "Formation of annular gap junctions", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "Adherens junctions interactions", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "Interaction between L1 and Ankyrins", "Cell-extracellular matrix interactions", "RHO GTPases activate IQGAPs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "MAP2K and MAPK activation", "Clathrin-mediated endocytosis"], "114654": ["Post-translational modification: synthesis of GPI-anchored proteins"], "114663": ["Synthesis of IP2, IP, and Ins in the cytosol"], "114664": ["Estrogen biosynthesis"], "11468": ["Smooth Muscle Contraction"], "114713": ["Regulation of RAS by GAPs"], "114714": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Factors involved in megakaryocyte development and platelet production"], "114715": ["Regulation of RAS by GAPs", "FGFRL1 modulation of FGFR1 signaling"], "114716": ["Regulation of RAS by GAPs", "FGFRL1 modulation of FGFR1 signaling"], "11472": ["Platelet degranulation ", "Striated Muscle Contraction", "Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade"], "11474": ["Striated Muscle Contraction"], "114741": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Transcription Elongation"], "11475": ["Smooth Muscle Contraction"], "11479": ["Signaling by Activin"], "11480": ["Signaling by Activin", "Signaling by BMP"], "11481": ["Signaling by Activin", "Signaling by BMP"], "11482": ["Signaling by BMP"], "11484": ["Amino acid synthesis and interconversion (transamination)"], "11486": ["Purine salvage"], "11487": ["Degradation of the extracellular matrix", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "114873": ["DSCAM interactions"], "114874": ["Synthesis of PA"], "114875": ["Synthesis of IP3 and IP4 in the cytosol"], "11488": ["LGI-ADAM interactions"], "114886": ["eNOS activation", "Intracellular oxygen transport"], "11489": ["Invadopodia formation"], "11490": ["Degradation of the extracellular matrix", "Invadopodia formation"], "11491": ["Regulated proteolysis of p75NTR", "TNF signaling"], "11492": ["Invadopodia formation"], "11495": ["Interaction With The Zona Pellucida"], "11496": ["LGI-ADAM interactions"], "11501": ["Degradation of the extracellular matrix", "Neutrophil degranulation"], "11504": ["O-glycosylation of TSR domain-containing proteins"], "11512": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "11513": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "11514": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "G alpha (s) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "11515": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "11516": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "11517": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "11518": ["Caspase-mediated cleavage of cytoskeletal proteins", "Miscellaneous transport and binding events"], "11519": ["Miscellaneous transport and binding events"], "11522": ["Abacavir metabolism", "RA biosynthesis pathway", "Ethanol oxidation"], "11529": ["Ethanol oxidation"], "11532": ["Ethanol oxidation"], "11534": ["Purine salvage"], "11535": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "11537": ["Platelet degranulation ", "Alternative complement activation", "Neutrophil degranulation"], "11539": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "11540": ["Adenosine P1 receptors", "G alpha (s) signalling events", "Surfactant metabolism"], "11541": ["Adenosine P1 receptors", "G alpha (s) signalling events", "Surfactant metabolism"], "11542": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "11545": ["POLB-Dependent Long Patch Base Excision Repair", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SUMOylation of DNA damage response and repair proteins", "HDR through MMEJ (alt-NHEJ)", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "11546": ["POLB-Dependent Long Patch Base Excision Repair", "HDR through MMEJ (alt-NHEJ)", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "11548": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "11549": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "11550": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "11551": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "G alpha (z) signalling events", "Surfactant metabolism"], "11552": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "G alpha (i) signalling events", "G alpha (z) signalling events"], "11553": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "G alpha (z) signalling events", "Surfactant metabolism"], "11554": ["Adrenoceptors", "G alpha (s) signalling events"], "11555": ["Adrenoceptors", "G alpha (s) signalling events", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "11556": ["Adrenoceptors", "G alpha (s) signalling events"], "11564": ["Purine ribonucleoside monophosphate biosynthesis"], "11565": ["Purine ribonucleoside monophosphate biosynthesis"], "11566": ["Purine ribonucleoside monophosphate biosynthesis"], "11569": ["PRC2 methylates histones and DNA", "PKMTs methylate histone lysines"], "11571": ["Neutrophil degranulation"], "11572": ["Neutrophil degranulation"], "11576": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "11593": ["Neutrophil degranulation"], "11595": ["Degradation of the extracellular matrix", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "ECM proteoglycans"], "11596": ["TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "11600": ["Tie2 Signaling", "RAF/MAP kinase cascade"], "11601": ["Tie2 Signaling"], "11602": ["Tie2 Signaling"], "11603": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "ECM proteoglycans", "Retinoid metabolism and transport"], "11605": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "11606": ["Metabolism of Angiotensinogen to Angiotensins", "Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "11607": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "11608": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "11609": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "11611": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import"], "11614": ["Nuclear Receptor transcription pathway"], "11615": ["Methylation", "Sulfur amino acid metabolism"], "11622": ["Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "11624": ["Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "11625": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "11632": ["Aryl hydrocarbon receptor signalling"], "11636": ["Interconversion of nucleotide di- and triphosphates"], "11637": ["Interconversion of nucleotide di- and triphosphates"], "11639": ["Interconversion of nucleotide di- and triphosphates"], "11640": ["Factors involved in megakaryocyte development and platelet production"], "11647": ["Post-translational modification: synthesis of GPI-anchored proteins"], "11648": ["Synthesis of PA", "Post-translational modification: synthesis of GPI-anchored proteins", "Intra-Golgi traffic", "Digestion"], "11650": ["Synthesis of PA", "Post-translational modification: synthesis of GPI-anchored proteins", "Intra-Golgi traffic", "Digestion"], "11651": ["PIP3 activates AKT signaling", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "mTOR signalling", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "eNOS activation", "Integrin alphaIIb beta3 signaling", "Deactivation of the beta-catenin transactivating complex", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "VEGFR2 mediated vascular permeability", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "11652": ["PIP3 activates AKT signaling", "Activation of AKT2", "Inhibition of TSC complex formation by PKB", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "Deactivation of the beta-catenin transactivating complex", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "VEGFR2 mediated vascular permeability", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation"], "11655": ["Heme biosynthesis"], "11656": ["Heme biosynthesis"], "11657": ["Platelet degranulation ", "Recycling of bile acids and salts", "Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Transport of organic anions", "Post-translational protein phosphorylation", "HDL remodeling"], "11666": ["ABC transporters in lipid homeostasis", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids"], "11668": ["RA biosynthesis pathway", "Ethanol oxidation"], "11669": ["Ethanol oxidation"], "11670": ["Phase I - Functionalization of compounds"], "116701": ["FGFRL1 modulation of FGFR1 signaling"], "11671": ["Sphingolipid de novo biosynthesis", "Alpha-oxidation of phytanate"], "116733": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "11674": ["Platelet degranulation ", "Neutrophil degranulation", "Gluconeogenesis"], "116748": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "11676": ["Neutrophil degranulation", "Gluconeogenesis"], "11677": ["Pregnenolone biosynthesis"], "11684": ["Synthesis of Hepoxilins (HX) and Trioxilins (TrX)", "Synthesis of Lipoxins (LX)", "Synthesis of 12-eicosatetraenoic acid derivatives", "Biosynthesis of DHA-derived SPMs"], "116847": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "116849": ["Interleukin-20 family signaling"], "116852": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "11686": ["Synthesis of 12-eicosatetraenoic acid derivatives"], "11687": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Biosynthesis of E-series 18(R)-resolvins"], "116870": ["HDACs deacetylate histones", "SUMOylation of transcription factors", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "116871": ["HDACs deacetylate histones", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "11688": ["Synthesis of 15-eicosatetraenoic acid derivatives"], "11689": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)", "Neutrophil degranulation", "Biosynthesis of E-series 18(S)-resolvins"], "116891": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "ER Quality Control Compartment (ERQC)"], "11690": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)"], "116903": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "116905": ["Synthesis of diphthamide-EEF2"], "116914": ["Vitamin B1 (thiamin) metabolism"], "116939": ["Acyl chain remodeling of DAG and TAG"], "116940": ["snRNP Assembly", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "11698": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "11699": ["Scavenging of heme from plasma"], "117004": ["Olfactory Signaling Pathway"], "117005": ["Olfactory Signaling Pathway"], "11702": ["Metabolism of polyamines"], "11704": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "11705": ["Signaling by BMP"], "117066": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "117146": ["Antigen processing: Ubiquitination & Proteasome degradation"], "117147": ["Conjugation of benzoate with glycine"], "117149": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane"], "117150": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "117158": ["Scavenging by Class A Receptors"], "117160": ["Stimuli-sensing channels"], "11717": ["Neutrophil degranulation", "Purine salvage"], "117172": ["Keratinization"], "117197": ["Golgi Associated Vesicle Biogenesis"], "11720": ["Methylation", "Sulfur amino acid metabolism", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "11722": ["Digestion of dietary carbohydrate"], "11727": ["Adherens junctions interactions"], "11731": ["Adherens junctions interactions"], "11732": ["Miscellaneous transport and binding events"], "11733": ["Interaction between L1 and Ankyrins", "Neurofascin interactions", "COPI-mediated anterograde transport"], "11735": ["Interaction between L1 and Ankyrins", "COPI-mediated anterograde transport"], "11737": ["HuR (ELAVL1) binds and stabilizes mRNA"], "11740": ["Regulation of insulin secretion"], "11747": ["Platelet degranulation "], "11754": ["Phase I - Functionalization of compounds"], "11757": ["Detoxification of Reactive Oxygen Species"], "11758": ["Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "117586": ["Platelet degranulation ", "Neutrophil degranulation"], "117589": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "117590": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "117591": ["Cellular hexose transport"], "117592": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "117600": ["Rho GTPase cycle"], "117606": ["CDO in myogenesis", "Activation of SMO"], "11761": ["Vitamins B6 activation to pyridoxal phosphate"], "11764": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "11765": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "11766": ["Lysosome Vesicle Biogenesis"], "11767": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation"], "11768": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "11769": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "11770": ["Triglyceride catabolism"], "11771": ["Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "11772": ["Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Neutrophil degranulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "11773": ["Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "11774": ["Golgi Associated Vesicle Biogenesis"], "11777": ["Golgi Associated Vesicle Biogenesis"], "11781": ["Lysosome Vesicle Biogenesis"], "11782": ["Lysosome Vesicle Biogenesis"], "11783": ["Neutrophil degranulation", "Regulation of the apoptosome activity"], "11785": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "11789": ["Apoptotic cleavage of cellular proteins", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Deactivation of the beta-catenin transactivating complex", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Ovarian tumor domain proteases"], "11792": ["Displacement of DNA glycosylase by APEX1", "POLB-Dependent Long Patch Base Excision Repair", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "PCNA-Dependent Long Patch Base Excision Repair", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "Resolution of Abasic Sites (AP sites)"], "11793": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy"], "11796": ["NOD1/2 Signaling Pathway", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "IKK complex recruitment mediated by RIP1"], "11797": ["Apoptotic cleavage of cellular proteins", "NOD1/2 Signaling Pathway", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "IKK complex recruitment mediated by RIP1"], "11798": ["SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC, XIAP-regulated apoptotic response", "Deactivation of the beta-catenin transactivating complex", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Regulation of necroptotic cell death", "Regulation of PTEN localization", "Regulation of PTEN stability and activity"], "11799": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Neddylation"], "11804": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "11806": ["Platelet degranulation ", "ABC transporters in lipid homeostasis", "Scavenging of heme from plasma", "Scavenging by Class B Receptors", "Scavenging by Class A Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "HDL assembly", "Chylomicron remodeling", "HDL clearance", "HDL remodeling", "Retinoid metabolism and transport"], "11807": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Retinoid metabolism and transport"], "11808": ["Chylomicron assembly", "Chylomicron remodeling", "Retinoid metabolism and transport"], "11810": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "11811": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "11812": ["VLDL assembly", "VLDL clearance"], "11813": ["Chylomicron assembly", "Chylomicron remodeling", "HDL remodeling", "Retinoid metabolism and transport"], "11814": ["Chylomicron assembly", "Chylomicron remodeling", "HDL remodeling", "Retinoid metabolism and transport"], "11815": ["Transport of fatty acids"], "11816": ["Scavenging by Class A Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Chylomicron clearance", "HDL remodeling", "Retinoid metabolism and transport"], "11818": ["Platelet degranulation "], "11820": ["Platelet degranulation ", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosome Vesicle Biogenesis", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "Post-translational protein phosphorylation", "TRAF6 mediated NF-kB activation"], "11821": ["Neutrophil degranulation", "Purine salvage"], "11826": ["Erythrocytes take up carbon dioxide and release oxygen", "Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "11827": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "11828": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "11829": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "11830": ["Passive transport by Aquaporins"], "11832": ["Transport of glycerol from adipocytes to the liver by Aquaporins", "Passive transport by Aquaporins"], "11833": ["Passive transport by Aquaporins"], "11834": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "11835": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "RUNX2 regulates osteoblast differentiation"], "11836": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway"], "11839": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "COPII-mediated vesicle transport", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "Cargo concentration in the ER", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "11840": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "MHC class II antigen presentation", "Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic"], "11842": ["Synthesis of PIPs at the Golgi membrane", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "11843": ["VxPx cargo-targeting to cilium", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "11844": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "11845": ["TBC/RABGAPs", "Clathrin-mediated endocytosis", "MET receptor recycling"], "118451": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "118454": ["Gap junction assembly"], "11846": ["Neutrophil degranulation", "Urea cycle"], "11847": ["Urea cycle"], "11848": ["GPVI-mediated activation cascade", "Axonal growth inhibition (RHOA activation)", "Rho GTPase cycle", "PI3K/AKT activation", "Axonal growth stimulation", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "G beta:gamma signalling through PI3Kgamma", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "PCP/CE pathway", "G alpha (12/13) signalling events", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate KTN1", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins", "RHO GTPases Activate Rhotekin and Rhophilins", "Ovarian tumor domain proteases", "ERBB2 Regulates Cell Motility", "Neutrophil degranulation", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "SLIT2:ROBO1 increases RHOA activity"], "11852": ["GPVI-mediated activation cascade", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins"], "11853": ["Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins"], "11854": ["Rho GTPase cycle", "RHO GTPases Activate Formins"], "11855": ["Rho GTPase cycle"], "11856": ["Rho GTPase cycle"], "11857": ["Rho GTPase cycle"], "11863": ["Regulation of gene expression by Hypoxia-inducible Factor", "Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "11864": ["Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "11867": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs"], "11876": ["RAF/MAP kinase cascade", "RET signaling"], "11881": ["Glycosphingolipid metabolism", "The activation of arylsulfatases", "CS/DS degradation", "Neutrophil degranulation"], "11883": ["Glycosphingolipid metabolism", "The activation of arylsulfatases", "Neutrophil degranulation"], "11886": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "11889": ["Asparagine N-linked glycosylation"], "11890": ["Asparagine N-linked glycosylation"], "11891": ["Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "11898": ["Urea cycle"], "11905": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "11906": ["RUNX3 regulates CDKN1A transcription"], "11908": ["CREB phosphorylation"], "11909": ["HATs acetylate histones", "Activation of the AP-1 family of transcription factors", "Estrogen-dependent gene expression"], "11920": ["DNA Damage/Telomere Stress Induced Senescence", "Regulation of HSF1-mediated heat shock response", "Autodegradation of the E3 ubiquitin ligase COP1", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Degradation", "G2/M DNA damage checkpoint", "Stabilization of p53"], "11927": ["Ion influx/efflux at host-pathogen interface"], "11928": ["Ion homeostasis", "Ion transport by P-type ATPases"], "11931": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "11932": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "11933": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "11936": ["Ion homeostasis", "Ion transport by P-type ATPases"], "11937": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "11938": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "11941": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "11944": ["Ion transport by P-type ATPases"], "11945": ["Ion transport by P-type ATPases"], "11946": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "11947": ["Mitochondrial protein import", "Formation of ATP by chemiosmotic coupling", "Cristae formation"], "11949": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "11950": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "11957": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "11958": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "11964": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "11966": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "11972": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "11973": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "11974": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "11975": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "11977": ["Ion influx/efflux at host-pathogen interface", "Ion transport by P-type ATPases"], "11979": ["Ion transport by P-type ATPases"], "11980": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "11981": ["Ion transport by P-type ATPases"], "11982": ["Ion transport by P-type ATPases"], "11984": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "11987": ["Amino acid transport across the plasma membrane"], "11988": ["Amino acid transport across the plasma membrane"], "11989": ["Amino acid transport across the plasma membrane"], "11991": ["AUF1 (hnRNP D0) binds and destabilizes mRNA", "mRNA Splicing - Major Pathway"], "11992": ["Branched-chain amino acid catabolism"], "11997": ["Estrogen biosynthesis", "Retinoid metabolism and transport"], "11998": ["Vasopressin-like receptors", "G alpha (q) signalling events", "G alpha (s) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Transport of organic anions", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "12000": ["Vasopressin-like receptors", "G alpha (s) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "12005": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "TCF dependent signaling in response to WNT", "Degradation of AXIN", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Ub-specific processing proteases"], "12006": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "Ub-specific processing proteases"], "12007": ["Miscellaneous transport and binding events"], "12009": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "12010": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "12012": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Peroxisomal protein import"], "12015": ["Activation of BAD and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "NRAGE signals death through JNK"], "12017": ["Regulation of HSF1-mediated heat shock response"], "12018": ["Activation and oligomerization of BAK protein", "Release of apoptotic factors from the mitochondria"], "12021": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "UCH proteinases", "Metalloprotease DUBs", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "G2/M DNA damage checkpoint"], "12028": ["Release of apoptotic factors from the mitochondria", "Activation, translocation and oligomerization of BAX", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "12032": ["Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans"], "12034": ["Processing of SMDT1"], "12035": ["Branched-chain amino acid catabolism"], "12036": ["Branched-chain amino acid catabolism"], "12038": ["Neurotransmitter clearance", "Synthesis of PC", "Synthesis, secretion, and deacylation of Ghrelin"], "12039": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "12040": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "12041": ["Branched-chain amino acid catabolism"], "12042": ["Activation of NF-kappaB in B cells", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "E3 ubiquitin ligases ubiquitinate target proteins"], "12043": ["Activation of BAD and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "The NLRP1 inflammasome"], "12048": ["BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "The NLRP1 inflammasome"], "12057": ["The retinoid cycle in cones (daylight vision)", "G alpha (i) signalling events", "Opsins"], "12061": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "12062": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "12064": ["Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through FRS2 and FRS3", "NTRK2 activates RAC1"], "12068": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "12070": ["NADE modulates death signalling"], "12091": ["Glycosphingolipid metabolism", "Sialic acid metabolism", "Neutrophil degranulation"], "12095": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "12096": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "12097": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "121021": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation"], "121022": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "12111": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans"], "12116": ["Sulfur amino acid metabolism", "Choline catabolism"], "12121": ["COPI-independent Golgi-to-ER retrograde traffic"], "12122": ["Activation of BAD and translocation to mitochondria ", "Activation and oligomerization of BAK protein", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation, translocation and oligomerization of BAX", "Activation, myristolyation of BID and translocation to mitochondria"], "12125": ["Activation of BIM and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "NRAGE signals death through JNK"], "12140": ["Triglyceride catabolism"], "12144": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "12145": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12151": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "12153": ["Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation", "HDL assembly"], "12154": ["Signaling by BMP", "Molecules associated with elastic fibres"], "12155": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "12156": ["Signaling by BMP", "Molecules associated with elastic fibres"], "12159": ["Molecules associated with elastic fibres", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "12162": ["Molecules associated with elastic fibres"], "12165": ["Signaling by BMP"], "12166": ["Signaling by BMP"], "12167": ["Signaling by BMP"], "12168": ["Signaling by BMP"], "12169": ["Apoptotic cleavage of cellular proteins", "Synthesis of PIPs at the plasma membrane"], "12175": ["CDO in myogenesis"], "12177": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "12181": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "12182": ["Post-translational modification: synthesis of GPI-anchored proteins", "Nicotinate metabolism", "Neutrophil degranulation"], "12183": ["Glycolysis"], "12189": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Metalloprotease DUBs", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "G2/M DNA damage checkpoint"], "12190": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "12192": ["Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "12209": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "12215": ["Degradation of the extracellular matrix", "Basigin interactions", "Integrin cell surface interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "12223": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling"], "12227": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "12229": ["Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated Ca+2 mobilization", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "RHO GTPases Activate WASPs and WAVEs", "G beta:gamma signalling through BTK", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "12231": ["Butyrophilin (BTN) family interactions"], "12234": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Deactivation of the beta-catenin transactivating complex", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neddylation", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "12235": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "12236": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "12237": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "12238": ["Neutrophil degranulation", "Neddylation"], "12257": ["Pregnenolone biosynthesis"], "12258": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Regulation of Complement cascade"], "12259": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "12260": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "12261": ["Intrinsic Pathway of Fibrin Clot Formation"], "12262": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "12263": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Complement cascade"], "12266": ["Alternative complement activation", "Activation of C3 and C5", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (i) signalling events", "Neutrophil degranulation", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "12267": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation", "Regulation of Complement cascade"], "12268": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "12273": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation", "Regulation of Complement cascade"], "12274": ["Terminal pathway of complement", "Regulation of Complement cascade"], "12279": ["Terminal pathway of complement", "Regulation of Complement cascade"], "12283": ["Energy dependent regulation of mTOR by LKB1-AMPK", "Neutrophil degranulation"], "12286": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion"], "12287": ["Presynaptic depolarization and calcium channel opening"], "12288": ["Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "12289": ["Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "12290": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion"], "12292": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "12294": ["Presynaptic depolarization and calcium channel opening", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "12295": ["Presynaptic depolarization and calcium channel opening", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "12296": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "12297": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "12298": ["Presynaptic depolarization and calcium channel opening", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "12299": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "12300": ["Presynaptic depolarization and calcium channel opening", "Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "12305": ["Non-integrin membrane-ECM interactions"], "12306": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "12310": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "12311": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "12313": ["CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "Platelet degranulation ", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "eNOS activation", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "VEGFR2 mediated vascular permeability", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Ion transport by P-type ATPases", "Activation of RAC1 downstream of NMDARs", "Long-term potentiation"], "12314": ["CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "Platelet degranulation ", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "eNOS activation", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "VEGFR2 mediated vascular permeability", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Ion transport by P-type ATPases", "Activation of RAC1 downstream of NMDARs", "Long-term potentiation"], "12315": ["CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "Platelet degranulation ", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "eNOS activation", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "VEGFR2 mediated vascular permeability", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Ion transport by P-type ATPases", "Activation of RAC1 downstream of NMDARs", "Long-term potentiation"], "12317": ["ER-Phagosome pathway", "Scavenging by Class A Receptors", "Calnexin/calreticulin cycle", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "12321": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "12322": ["HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Ca2+ pathway", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Interferon gamma signaling", "Ion transport by P-type ATPases"], "12323": ["HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Interferon gamma signaling", "Ion transport by P-type ATPases"], "12325": ["HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Interferon gamma signaling", "Ion transport by P-type ATPases"], "12326": ["CaMK IV-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"], "12330": ["MHC class II antigen presentation", "Interleukin-35 Signalling", "Calnexin/calreticulin cycle", "Interleukin-27 signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "12331": ["Neutrophil degranulation"], "12333": ["Degradation of the extracellular matrix", "Neutrophil degranulation", "Formation of the cornified envelope"], "12334": ["Degradation of the extracellular matrix"], "12335": ["Degradation of the extracellular matrix"], "12336": ["Degradation of the extracellular matrix", "Formation of the cornified envelope"], "12337": ["Degradation of the extracellular matrix"], "12338": ["Degradation of the extracellular matrix"], "12339": ["Degradation of the extracellular matrix"], "12343": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Advanced glycosylation endproduct receptor signaling", "Factors involved in megakaryocyte development and platelet production"], "12344": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "12345": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Factors involved in megakaryocyte development and platelet production"], "12346": ["Erythrocytes take up carbon dioxide and release oxygen", "Reversible hydration of carbon dioxide"], "12349": ["Erythrocytes take up carbon dioxide and release oxygen", "Reversible hydration of carbon dioxide"], "12350": ["Reversible hydration of carbon dioxide"], "12351": ["Erythrocytes take up carbon dioxide and release oxygen", "Reversible hydration of carbon dioxide"], "12352": ["Reversible hydration of carbon dioxide"], "12353": ["Reversible hydration of carbon dioxide"], "12354": ["Reversible hydration of carbon dioxide"], "12355": ["Nuclear Receptor transcription pathway"], "12359": ["Detoxification of Reactive Oxygen Species", "Neutrophil degranulation", "Peroxisomal protein import"], "12361": ["Dopamine Neurotransmitter Release Cycle", "Neurexins and neuroligins"], "12362": ["NOD1/2 Signaling Pathway", "Interleukin-1 processing"], "12363": ["NOD1/2 Signaling Pathway"], "12365": ["Formation of the cornified envelope"], "12366": ["NOD1/2 Signaling Pathway", "NADE modulates death signalling", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "12367": ["SMAC, XIAP-regulated apoptotic response", "NADE modulates death signalling", "Activation of DNA fragmentation factor", "Caspase-mediated cleavage of cytoskeletal proteins", "Apoptotic cleavage of cell adhesion  proteins", "Caspase activation via Dependence Receptors in the absence of ligand", "Other interleukin signaling"], "12368": ["Caspase-mediated cleavage of cytoskeletal proteins", "Breakdown of the nuclear lamina"], "12369": ["SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Apoptotic cleavage of cellular proteins", "SMAC, XIAP-regulated apoptotic response", "Caspase-mediated cleavage of cytoskeletal proteins"], "12370": ["Apoptotic cleavage of cellular proteins", "Caspase activation via Death Receptors in the presence of ligand", "NOD1/2 Signaling Pathway", "TRIF-mediated programmed cell death", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "CLEC7A/inflammasome pathway", "Dimerization of procaspase-8", "Activation, myristolyation of BID and translocation to mitochondria", "Apoptotic execution phase", "FasL/ CD95L signaling", "TRAIL  signaling"], "12371": ["NOD1/2 Signaling Pathway", "AKT phosphorylates targets in the cytosol", "Caspase activation via Dependence Receptors in the absence of ligand"], "12372": ["Stimuli-sensing channels", "Ion homeostasis"], "12373": ["Stimuli-sensing channels", "Ion homeostasis"], "12374": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "12380": ["Degradation of the extracellular matrix"], "12385": ["CDO in myogenesis", "Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "RHO GTPases activate IQGAPs"], "12386": ["CDO in myogenesis"], "12387": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "TCF dependent signaling in response to WNT", "Formation of the beta-catenin:TCF transactivating complex", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Apoptotic cleavage of cell adhesion  proteins", "CDO in myogenesis", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Adherens junctions interactions", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "VEGFR2 mediated vascular permeability", "RHO GTPases activate IQGAPs", "RUNX3 regulates WNT signaling"], "12388": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability"], "12389": ["eNOS activation", "NOSTRIN mediated eNOS trafficking", "Basigin interactions", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "VEGFR2 mediated vascular permeability"], "12391": ["Smooth Muscle Contraction"], "12393": ["Transcriptional regulation by RUNX2", "Regulation of RUNX2 expression and activity", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates bone development"], "12394": ["Organic cation transport", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "RUNX1 regulates estrogen receptor mediated transcription", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX1 regulates transcription of genes involved in interleukin signaling", "Estrogen-dependent gene expression"], "12400": ["RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Transcriptional regulation by RUNX2", "RUNX1 regulates estrogen receptor mediated transcription", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX1 regulates transcription of genes involved in interleukin signaling", "Regulation of RUNX3 expression and activity", "RUNX3 regulates p14-ARF", "Estrogen-dependent gene expression"], "12402": ["Interleukin-6 signaling", "Spry regulation of FGF signaling", "Regulation of KIT signaling", "EGFR downregulation", "TGF-beta receptor signaling activates SMADs", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Negative regulation of MET activity", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Regulation of signaling by CBL"], "12406": ["Collagen biosynthesis and modifying enzymes"], "12408": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "12411": ["Cysteine formation from homocysteine"], "12416": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "12417": ["RNA Polymerase I Chain Elongation", "Transcriptional Regulation by E2F6"], "12418": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "12419": ["Factors involved in megakaryocyte development and platelet production"], "12421": ["Macroautophagy"], "12424": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "12425": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "12426": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Gastrin-CREB signalling pathway via PKC and MAPK"], "12427": ["G0 and Early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Ub-specific processing proteases", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry"], "12428": ["G0 and Early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Ub-specific processing proteases", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry"], "12442": ["Resolution of Sister Chromatid Cohesion", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "12443": ["SCF(Skp2)-mediated degradation of p27/p21", "RMTs methylate histone arginines", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "PTK6 Regulates Cell Cycle", "Transcriptional regulation by RUNX2", "Regulation of RUNX1 Expression and Activity", "RUNX3 regulates p14-ARF"], "12444": ["Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "12445": ["MAPK6/MAPK4 signaling", "Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "12447": ["G0 and Early G1", "SCF(Skp2)-mediated degradation of p27/p21", "DNA Damage/Telomere Stress Induced Senescence", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "p53-Dependent G1 DNA Damage Response", "PTK6 Regulates Cell Cycle"], "12448": ["G0 and Early G1", "SCF(Skp2)-mediated degradation of p27/p21", "DNA Damage/Telomere Stress Induced Senescence", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "p53-Dependent G1 DNA Damage Response"], "12449": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "12450": ["Regulation of TP53 Degradation"], "12454": ["Formation of RNA Pol II elongation complex ", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "12455": ["Formation of RNA Pol II elongation complex ", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation", "Estrogen-dependent gene expression"], "12458": ["Beta defensins", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12460": ["Detoxification of Reactive Oxygen Species"], "12461": ["Association of TriC/CCT with target proteins during biosynthesis", "Neutrophil degranulation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "12462": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "12464": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "12467": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "12468": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "12469": ["Association of TriC/CCT with target proteins during biosynthesis", "Neutrophil degranulation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "12475": ["Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "Transfer of LPS from LBP carrier to CD14", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "12476": ["Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly"], "12477": ["CTLA4 inhibitory signaling"], "12478": ["PIP3 activates AKT signaling", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "12479": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "12483": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "12487": ["PIP3 activates AKT signaling", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "12490": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "12491": ["Platelet degranulation ", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Scavenging by Class B Receptors", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation"], "12492": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "12494": ["Nicotinate metabolism"], "12495": ["Phosphate bond hydrolysis by NTPDase proteins"], "12496": ["Phosphate bond hydrolysis by NTPDase proteins"], "12497": ["Phosphate bond hydrolysis by NTPDase proteins"], "12499": ["Phosphate bond hydrolysis by NTPDase proteins"], "12500": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "12501": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "12502": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "PD-1 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "12503": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "PD-1 signaling"], "12504": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling", "Other interleukin signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "12505": ["Degradation of the extracellular matrix", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Hyaluronan uptake and degradation", "Neutrophil degranulation"], "12506": ["Cell surface interactions at the vascular wall"], "12508": ["Neutrophil degranulation"], "12509": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "12512": ["Platelet degranulation ", "Neutrophil degranulation"], "12514": ["Neutrophil degranulation"], "12517": ["Other semaphorin interactions"], "12518": ["CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "12519": ["PIP3 activates AKT signaling", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "12520": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Regulation of Complement cascade"], "12523": ["Cell surface interactions at the vascular wall"], "12524": ["PIP3 activates AKT signaling", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "12525": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "12526": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "12527": ["Platelet degranulation ", "Sperm:Oocyte Membrane Binding"], "12530": ["Activation of ATR in response to replication stress", "Ub-specific processing proteases", "Cyclin E associated events during G1/S transition ", "Cyclin A/B1/B2 associated events during G2/M transition", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Cyclin A:Cdk2-associated events at S phase entry"], "12531": ["Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A:Cdk2-associated events at S phase entry"], "12532": ["Polo-like kinase mediated events", "Activation of ATR in response to replication stress", "RHO GTPases activate PKNs", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Cyclin A/B1/B2 associated events during G2/M transition", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "12534": ["MAPK3 (ERK1) activation", "APC/C:Cdc20 mediated degradation of Cyclin B", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Phosphorylation of Emi1", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "MAPK6/MAPK4 signaling", "Ovarian tumor domain proteases", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Degradation", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2"], "12537": ["Recruitment of mitotic centrosome proteins and complexes"], "12539": ["Signaling by ERBB2", "Downregulation of ERBB2 signaling"], "12540": ["GPVI-mediated activation cascade", "EGFR downregulation", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "CDO in myogenesis", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "RHO GTPases activate KTN1", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "MAPK6/MAPK4 signaling", "G beta:gamma signalling through CDC42", "Factors involved in megakaryocyte development and platelet production"], "12544": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "12545": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "12549": ["Rho GTPase cycle"], "12550": ["Degradation of the extracellular matrix", "Integrin cell surface interactions", "Apoptotic cleavage of cell adhesion  proteins", "Adherens junctions interactions", "RHO GTPases activate IQGAPs"], "12552": ["Adherens junctions interactions"], "12554": ["Adherens junctions interactions"], "12555": ["CDO in myogenesis", "Adherens junctions interactions"], "12557": ["Adherens junctions interactions"], "12558": ["CDO in myogenesis", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Adherens junctions interactions", "Post-translational protein phosphorylation"], "12560": ["Adherens junctions interactions"], "12561": ["CDO in myogenesis", "Adherens junctions interactions"], "12562": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability"], "12563": ["Adherens junctions interactions"], "12564": ["Adherens junctions interactions"], "12565": ["Adherens junctions interactions"], "12566": ["G0 and Early G1", "Activation of ATR in response to replication stress", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates Cell Cycle"], "12567": ["SCF(Skp2)-mediated degradation of p27/p21", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "RMTs methylate histone arginines", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "PTK6 Regulates Cell Cycle", "Transcriptional regulation by RUNX2"], "12568": ["DARPP-32 events", "CRMPs in Sema3A signaling", "Regulation of TP53 Activity through Phosphorylation"], "12569": ["CRMPs in Sema3A signaling", "Regulation of TP53 Activity through Phosphorylation"], "12571": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "12572": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "Cyclin A/B1/B2 associated events during G2/M transition", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "12575": ["SCF(Skp2)-mediated degradation of p27/p21", "AKT phosphorylates targets in the cytosol", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "12576": ["SCF(Skp2)-mediated degradation of p27/p21", "AKT phosphorylates targets in the cytosol", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates Cell Cycle"], "12577": ["Cyclin D associated events in G1"], "12579": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "12580": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "12581": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "12583": ["Degradation of cysteine and homocysteine"], "12589": ["Intraflagellar transport"], "12608": ["Senescence-Associated Secretory Phenotype (SASP)"], "12615": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "12617": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "12622": ["Signaling by BMP"], "12623": ["Metabolism of Angiotensinogen to Angiotensins", "Phase I - Functionalization of compounds"], "12628": ["Regulation of Complement cascade"], "12630": ["Regulation of Complement cascade"], "12633": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "TRAIL  signaling"], "12638": ["ABC-family proteins mediated transport", "RHO GTPases regulate CFTR trafficking", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "12640": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glycoprotein hormones", "Thyroxine biosynthesis", "Hormone ligand-binding receptors", "G alpha (s) signalling events", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Reactions specific to the complex N-glycan synthesis pathway"], "12642": ["Synthesis of bile acids and bile salts"], "12647": ["Synthesis of PC", "Acetylcholine Neurotransmitter Release Cycle"], "12649": ["Signaling by SCF-KIT", "Activation of ATR in response to replication stress", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"], "12652": ["Antimicrobial peptides"], "12653": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "12654": ["Neutrophil degranulation"], "12655": ["Digestion of dietary carbohydrate"], "12659": ["Interaction With The Zona Pellucida"], "12660": ["Synthesis of PC", "Synthesis of PE"], "12662": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "12663": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "12669": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "12671": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "12672": ["Muscarinic acetylcholine receptors", "G alpha (i) signalling events"], "12675": ["Activation of NF-kappaB in B cells", "NOD1/2 Signaling Pathway", "RIP-mediated NFkB activation via ZBP1", "AKT phosphorylates targets in the cytosol", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "12683": ["Lipid particle organization"], "12686": ["Synthesis of very long-chain fatty acyl-CoAs"], "12695": ["Tight junction interactions"], "12700": ["Neddylation"], "12702": ["Interleukin-6 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "PTK6 Activates STAT3", "Neddylation", "Interferon alpha/beta signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "12703": ["Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interferon alpha/beta signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "12704": ["RHO GTPases activate CIT"], "12705": ["Activation of the TFAP2 (AP-2) family of transcription factors", "Estrogen-dependent gene expression"], "12709": ["Creatine metabolism"], "12715": ["Creatine metabolism"], "12716": ["Creatine metabolism"], "12723": ["Stimuli-sensing channels"], "12724": ["Stimuli-sensing channels"], "12727": ["Stimuli-sensing channels"], "12728": ["Stimuli-sensing channels"], "12733": ["Stimuli-sensing channels"], "12757": ["Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "12759": ["Platelet degranulation ", "Terminal pathway of complement", "Antimicrobial peptides", "Regulation of Complement cascade"], "12764": ["Sialic acid metabolism"], "12765": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "12766": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12767": ["Signaling by ROBO receptors", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12768": ["G alpha (i) signalling events"], "12769": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12770": ["G alpha (i) signalling events"], "12771": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12772": ["Beta defensins", "G alpha (i) signalling events"], "12773": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12774": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12775": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12776": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12777": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12778": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "12780": ["ABC-family proteins mediated transport"], "12788": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "12789": ["VxPx cargo-targeting to cilium"], "12793": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "12794": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "12795": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "12798": ["Neutrophil degranulation"], "12801": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "12802": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "12803": ["IL-6-type cytokine receptor ligand interactions"], "12804": ["IL-6-type cytokine receptor ligand interactions"], "12813": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "Collagen chain trimerization"], "12814": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "12815": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "12816": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "12817": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions", "Collagen chain trimerization"], "12818": ["Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "12819": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "12821": ["Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly", "Collagen chain trimerization"], "12822": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Laminin interactions", "Collagen chain trimerization"], "12823": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "12824": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "12825": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "12826": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Non-integrin membrane-ECM interactions", "NCAM1 interactions", "Collagen chain trimerization"], "12827": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Non-integrin membrane-ECM interactions", "NCAM1 interactions", "Collagen chain trimerization"], "12828": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Non-integrin membrane-ECM interactions", "NCAM1 interactions", "Collagen chain trimerization"], "12829": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Non-integrin membrane-ECM interactions", "NCAM1 interactions", "Collagen chain trimerization"], "12830": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Non-integrin membrane-ECM interactions", "NCAM1 interactions", "Collagen chain trimerization"], "12831": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "12832": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "12833": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "12834": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "12835": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "12836": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "COPII-mediated vesicle transport", "Integrin cell surface interactions", "Anchoring fibril formation", "Laminin interactions", "Cargo concentration in the ER", "Collagen chain trimerization"], "12837": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Collagen chain trimerization"], "12839": ["Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "12840": ["Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "12841": ["Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "12842": ["GPVI-mediated activation cascade", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "MET activates PTK2 signaling", "Collagen chain trimerization"], "12843": ["GPVI-mediated activation cascade", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "MET activates PTK2 signaling", "Collagen chain trimerization"], "12845": ["Integrin cell surface interactions", "ECM proteoglycans"], "12846": ["Methylation", "Enzymatic degradation of dopamine by COMT"], "12847": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "12848": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "12854": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "12870": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Metal ion SLC transporters", "Post-translational protein phosphorylation", "Iron uptake and transport"], "12873": ["Metabolism of Angiotensinogen to Angiotensins"], "12874": ["Golgi Associated Vesicle Biogenesis"], "12879": ["Trafficking of myristoylated proteins to the cilium"], "12889": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "12891": ["Glycerophospholipid biosynthesis"], "12892": ["Heme biosynthesis"], "12894": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Signaling by Retinoic Acid"], "12895": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Signaling by Retinoic Acid"], "12896": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "12902": ["Regulation of Complement cascade"], "12903": ["RA biosynthesis pathway"], "12904": ["Signaling by Retinoic Acid"], "12905": ["TP53 Regulates Transcription of Caspase Activators and Caspases"], "12908": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import"], "12909": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "12912": ["AKT phosphorylates targets in the nucleus", "CREB phosphorylation", "NCAM signaling for neurite out-growth", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "Gastrin-CREB signalling pathway via PKC and MAPK"], "12913": ["CREB3 factors activate genes"], "12914": ["Regulation of gene expression by Hypoxia-inducible Factor", "Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Attenuation phase", "Notch-HLH transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "CD209 (DC-SIGN) signaling", "Activation of the TFAP2 (AP-2) family of transcription factors", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX3 regulates NOTCH signaling", "Estrogen-dependent gene expression", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Regulation of FOXO transcriptional activity by acetylation"], "12918": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "12919": ["Class B/2 (Secretin family receptors)"], "12921": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "12922": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "12927": ["Downstream signal transduction", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "12928": ["ARMS-mediated activation", "Downstream signal transduction", "Regulation of actin dynamics for phagocytic cup formation", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAP1 and RAC1", "MET receptor recycling", "Regulation of signaling by CBL"], "12929": ["Frs2-mediated activation", "Downstream signal transduction", "MET activates RAP1 and RAC1", "MET receptor recycling", "Erythropoietin activates RAS", "Regulation of signaling by CBL"], "12931": ["IL-6-type cytokine receptor ligand interactions", "Interleukin-27 signaling"], "12933": ["CRMPs in Sema3A signaling"], "12934": ["CRMPs in Sema3A signaling", "Recycling pathway of L1"], "12944": ["Classical antibody-mediated complement activation"], "12950": ["ECM proteoglycans"], "12955": ["HSF1-dependent transactivation"], "12971": ["Lysine catabolism"], "12974": ["Citric acid cycle (TCA cycle)"], "12977": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Other interleukin signaling", "Post-translational protein phosphorylation"], "12978": ["Other interleukin signaling"], "12981": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "12982": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Surfactant metabolism", "Interleukin receptor SHC signaling"], "12983": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Surfactant metabolism", "Interleukin receptor SHC signaling"], "12984": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Surfactant metabolism", "Interleukin receptor SHC signaling"], "12985": ["Other interleukin signaling"], "12986": ["Other interleukin signaling"], "12988": ["GAB1 signalosome", "Phosphorylation of CD3 and TCR zeta chains", "Integrin alphaIIb beta3 signaling", "PD-1 signaling", "MAP2K and MAPK activation"], "12995": ["WNT mediated activation of DVL", "Signal transduction by L1", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "13000": ["WNT mediated activation of DVL", "Signal transduction by L1", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "13001": ["WNT mediated activation of DVL", "Signal transduction by L1", "Neutrophil degranulation", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "13002": ["Neutrophil degranulation", "GABA synthesis, release, reuptake and degradation"], "13003": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "13004": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans"], "13006": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins"], "13010": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "13014": ["Neutrophil degranulation"], "13016": ["Deactivation of the beta-catenin transactivating complex", "SUMOylation of transcription cofactors", "Repression of WNT target genes"], "13017": ["Repression of WNT target genes"], "13019": ["IL-6-type cytokine receptor ligand interactions"], "13026": ["Synthesis of PC"], "13030": ["Collagen degradation", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "Neutrophil degranulation"], "13032": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Neutrophil degranulation"], "13033": ["Collagen degradation", "Metabolism of Angiotensinogen to Angiotensins", "MHC class II antigen presentation", "Neutrophil degranulation"], "13034": ["MHC class II antigen presentation"], "13035": ["Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Antimicrobial peptides"], "13036": ["MHC class II antigen presentation", "Surfactant metabolism", "Neutrophil degranulation"], "13038": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Trafficking and processing of endosomal TLR", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "13039": ["Activation of Matrix Metalloproteinases", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "13040": ["Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "Neutrophil degranulation"], "13041": ["Platelet degranulation "], "13043": ["Clathrin-mediated endocytosis"], "13047": ["Intra-Golgi traffic"], "13051": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "13057": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation"], "13058": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation"], "13070": ["Pregnenolone biosynthesis", "Endogenous sterols"], "13072": ["Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis", "Endogenous sterols"], "13074": ["Androgen biosynthesis", "Glucocorticoid biosynthesis"], "13075": ["Estrogen biosynthesis", "Endogenous sterols"], "13076": ["Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of protectins"], "13077": ["Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Aflatoxin activation and detoxification", "Biosynthesis of protectins", "Biosynthesis of maresin-like SPMs"], "13078": ["Endogenous sterols", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "13079": ["Mineralocorticoid biosynthesis", "Endogenous sterols"], "13081": ["Vitamin D (calciferol) metabolism"], "13082": ["Vitamins"], "13086": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions", "Aflatoxin activation and detoxification"], "13087": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions", "Aflatoxin activation and detoxification"], "13088": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "13089": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "13090": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "13094": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "13095": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "13096": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "13097": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "13098": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "13099": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "13101": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "13105": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "13106": ["Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "13107": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "13109": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "13110": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "13112": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "13113": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "13114": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "13115": ["Vitamin D (calciferol) metabolism", "Vitamins"], "13116": ["Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Endogenous sterols"], "13117": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "13118": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "13119": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "13120": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "13121": ["Cholesterol biosynthesis", "Endogenous sterols"], "13122": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols"], "13123": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols"], "13124": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Nicotinamide salvaging", "Eicosanoids", "Sterols are 12-hydroxylated by CYP8B1", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "13131": ["Reelin signalling pathway"], "13132": ["Gap junction degradation", "Formation of annular gap junctions", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "13136": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "13137": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "13138": ["ECM proteoglycans", "O-linked glycosylation", "Regulation of expression of SLITs and ROBOs"], "13139": ["Effects of PIP2 hydrolysis"], "13142": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import"], "13162": ["Dopamine clearance from the synaptic cleft", "Na+/Cl- dependent neurotransmitter transporters"], "13163": ["SUMOylation of transcription cofactors", "Regulation of TP53 Degradation"], "13166": ["Catecholamine biosynthesis"], "13167": ["Mitochondrial Fatty Acid Beta-Oxidation"], "13169": ["Caspase-mediated cleavage of cytoskeletal proteins", "Neurexins and neuroligins", "Neutrophil degranulation"], "13171": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "13176": ["Netrin-1 signaling", "DCC mediated attractive signaling", "Caspase activation via Dependence Receptors in the absence of ligand"], "13177": ["mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "13178": ["Pyrimidine salvage"], "13179": ["Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans"], "13180": ["Phenylalanine and tyrosine catabolism"], "13190": ["Melanin biosynthesis"], "13191": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "13194": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "13195": ["Serotonin and melatonin biosynthesis"], "13196": ["VxPx cargo-targeting to cilium"], "13197": ["TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "13200": ["Neutrophil degranulation"], "13204": ["mRNA Splicing - Major Pathway"], "13205": ["Neutrophil degranulation"], "13207": ["SUMOylation of transcription cofactors", "mRNA Splicing - Major Pathway", "Estrogen-dependent gene expression"], "13209": ["mRNA decay by 5' to 3' exoribonuclease"], "13211": ["RIP-mediated NFkB activation via ZBP1", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "mRNA Splicing - Major Pathway"], "13214": ["Beta defensins", "Defensins"], "13244": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "13340": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "13346": ["Striated Muscle Contraction"], "13347": ["Activation of DNA fragmentation factor"], "13350": ["Acyl chain remodeling of DAG and TAG", "Neutrophil degranulation", "Triglyceride biosynthesis"], "13358": ["Fatty acyl-CoA biosynthesis"], "13360": ["Cholesterol biosynthesis via desmosterol"], "13361": ["Metabolism of folate and pterines"], "13363": ["Hedgehog ligand biogenesis", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Activation of SMO"], "13367": ["RHO GTPases Activate Formins", "ERBB2 Regulates Cell Motility", "Neutrophil degranulation"], "13368": ["Activation of DNA fragmentation factor"], "13371": ["Regulation of thyroid hormone activity"], "13380": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "13382": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Glycine degradation", "Pyruvate metabolism", "Branched-chain amino acid catabolism", "Lysine catabolism"], "13383": ["Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Activation of Ca-permeable Kainate Receptor", "RAF/MAP kinase cascade", "Synaptic adhesion-like molecules"], "13385": ["Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Activation of Ca-permeable Kainate Receptor", "RHO GTPases activate CIT", "RAF/MAP kinase cascade", "LGI-ADAM interactions", "Neurexins and neuroligins", "Synaptic adhesion-like molecules"], "13388": ["NOTCH3 Activation and Transmission of Signal to the Nucleus"], "13400": ["Ion homeostasis"], "13405": ["Striated Muscle Contraction"], "13406": ["ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "13423": ["Lysosome Vesicle Biogenesis"], "13424": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "13426": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "13427": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "13429": ["Toll Like Receptor 4 (TLR4) Cascade", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "13430": ["Toll Like Receptor 4 (TLR4) Cascade", "Gap junction degradation", "Formation of annular gap junctions", "NOSTRIN mediated eNOS trafficking", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "13433": ["PRC2 methylates histones and DNA", "SUMOylation of DNA methylation proteins"], "13435": ["PRC2 methylates histones and DNA", "RMTs methylate histone arginines"], "13436": ["PRC2 methylates histones and DNA", "SUMOylation of DNA methylation proteins"], "13448": ["PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "RET signaling"], "13449": ["Tie2 Signaling", "RET signaling"], "13476": ["Olfactory Signaling Pathway"], "13478": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "13479": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "13480": ["Synthesis of dolichyl-phosphate mannose"], "13481": ["Synthesis of dolichyl-phosphate mannose", "Synthesis of glycosylphosphatidylinositol (GPI)"], "13482": ["Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "13487": ["Multifunctional anion exchangers"], "13488": ["Dopamine receptors", "G alpha (s) signalling events"], "13489": ["Dopamine receptors", "G alpha (i) signalling events"], "13490": ["Dopamine receptors", "G alpha (i) signalling events"], "13491": ["Dopamine receptors", "G alpha (i) signalling events"], "13492": ["Dopamine receptors", "G alpha (s) signalling events"], "13505": ["Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "13506": ["Keratinization", "Formation of the cornified envelope"], "13507": ["Keratinization", "Formation of the cornified envelope"], "13508": ["DSCAM interactions"], "13510": ["Apoptotic cleavage of cell adhesion  proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "13511": ["Apoptotic cleavage of cell adhesion  proteins", "Keratinization", "Formation of the cornified envelope"], "13512": ["Apoptotic cleavage of cell adhesion  proteins", "Keratinization", "Formation of the cornified envelope"], "13518": ["Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly"], "13521": ["Transport and synthesis of PAPS", "Multifunctional anion exchangers"], "13531": ["Ub-specific processing proteases"], "13532": ["Ub-specific processing proteases"], "13537": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "13542": ["WNT mediated activation of DVL", "PCP/CE pathway", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins"], "13543": ["WNT mediated activation of DVL", "Signaling by Hippo", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "WNT5A-dependent internalization of FZD4", "RHO GTPases Activate Formins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "13544": ["WNT mediated activation of DVL", "PCP/CE pathway", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins"], "13548": ["G0 and Early G1"], "13555": ["CDC6 association with the ORC:origin complex", "G2 Phase", "Cyclin D associated events in G1"], "13557": ["CDC6 association with the ORC:origin complex", "G2 Phase", "Cyclin D associated events in G1"], "13559": ["G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Cyclin D associated events in G1"], "13586": ["Neutrophil degranulation", "Antimicrobial peptides"], "13587": ["Neutrophil degranulation", "Antimicrobial peptides"], "13589": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2"], "13590": ["Platelet degranulation "], "13595": ["Cholesterol biosynthesis via desmosterol"], "13601": ["Platelet degranulation "], "13602": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "13603": ["G alpha (i) signalling events", "Opsins"], "13605": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "13607": ["TNFs bind their physiological receptors"], "13608": ["TNFs bind their physiological receptors"], "13609": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "13610": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "13611": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "13614": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "13615": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "13616": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "13617": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "13618": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "13619": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "13626": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "13629": ["Peptide chain elongation", "Synthesis of diphthamide-EEF2", "Neutrophil degranulation", "Protein methylation"], "13631": ["mTORC1-mediated signalling"], "13636": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13637": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13638": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13639": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13640": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13641": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "13642": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "13643": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "13645": ["Platelet degranulation ", "Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "13649": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "EGFR Transactivation by Gastrin", "Signal transduction by L1", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "PTK6 promotes HIF1A stabilization", "Downregulation of ERBB2 signaling", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "13660": ["Factors involved in megakaryocyte development and platelet production"], "13665": ["L13a-mediated translational silencing of Ceruloplasmin expression", "PERK regulates gene expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "Recycling of eIF2:GDP"], "13666": ["PERK regulates gene expression"], "13667": ["Recycling of eIF2:GDP"], "13669": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "13682": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "Translation initiation complex formation", "Ribosomal scanning and start codon recognition"], "13684": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition"], "13685": ["mTORC1-mediated signalling", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "13706": ["Formation of the cornified envelope"], "13709": ["RUNX1 regulates transcription of genes involved in interleukin signaling"], "13710": ["Pre-NOTCH Transcription and Translation"], "13716": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "13717": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres"], "13723": ["Proton-coupled monocarboxylate transport"], "13726": ["Depolymerisation of the Nuclear Lamina"], "13733": ["Class B/2 (Secretin family receptors)"], "13800": ["Signaling by ROBO receptors"], "13801": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "13806": ["Gluconeogenesis"], "13807": ["Gluconeogenesis"], "13808": ["Gluconeogenesis"], "13809": ["Metabolism of Angiotensinogen to Angiotensins"], "13819": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Neddylation"], "13821": ["Trafficking of AMPA receptors", "Neurexins and neuroligins"], "13822": ["Neurexins and neuroligins"], "13823": ["Neurexins and neuroligins"], "13829": ["Miscellaneous transport and binding events"], "13830": ["Stimuli-sensing channels", "Neutrophil degranulation"], "13831": ["Transcriptional Regulation by E2F6"], "13835": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13836": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13837": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13838": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13839": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13840": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13841": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13842": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "13844": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "13845": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "13846": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "13849": ["Phase I - Functionalization of compounds"], "13850": ["Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Peroxisomal protein import"], "13853": ["Glycogen synthesis"], "13854": ["EGFR downregulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "13855": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "13856": ["Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS"], "13857": ["Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS"], "13858": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "13859": ["EGFR downregulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "13861": ["Neutrophil degranulation"], "13864": ["Nuclear Receptor transcription pathway"], "13865": ["Nuclear Receptor transcription pathway"], "13866": ["Signaling by ERBB2", "SHC1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Sema4D induced cell migration and growth-cone collapse", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "13867": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "PI3K events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "13869": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "Downregulation of ERBB4 signaling", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling", "Estrogen-dependent gene expression"], "13870": ["HDR through Single Strand Annealing (SSA)", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Fanconi Anemia Pathway"], "13871": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "13872": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "13874": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling"], "13875": ["Oncogene Induced Senescence"], "13885": ["Glutathione conjugation"], "13909": ["Phase I - Functionalization of compounds", "LDL clearance"], "13982": ["Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Ovarian tumor domain proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "RUNX1 regulates estrogen receptor mediated transcription", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "13983": ["PIP3 activates AKT signaling", "Nuclear Receptor transcription pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ESR-mediated signaling"], "13992": ["PTK6 Regulates Proteins Involved in RNA Processing"], "14013": ["PKMTs methylate histone lysines", "Regulation of PTEN gene transcription"], "14026": ["Signaling by ROBO receptors", "RHO GTPases Activate Formins"], "14027": ["Formation of the cornified envelope"], "14042": ["HS-GAG biosynthesis"], "14043": ["HS-GAG biosynthesis"], "140474": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "140475": ["Stimuli-sensing channels"], "14048": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "140481": ["Intra-Golgi traffic", "Reactions specific to the complex N-glycan synthesis pathway"], "140483": ["Histidine catabolism"], "14049": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "140492": ["Ca2+ activated K+ channels"], "140493": ["Ca2+ activated K+ channels"], "140494": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "140497": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "140498": ["G alpha (s) signalling events", "Relaxin receptors"], "140499": ["Antigen processing: Ubiquitination & Proteasome degradation"], "14050": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "14051": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "14056": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "140571": ["Other semaphorin interactions"], "140579": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "14058": ["Extrinsic Pathway of Fibrin Clot Formation", "Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "140580": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "14060": ["Common Pathway of Fibrin Clot Formation"], "14061": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Platelet Aggregation (Plug Formation)", "Regulation of Complement cascade"], "14062": ["Common Pathway of Fibrin Clot Formation", "Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)"], "140629": ["Antigen processing: Ubiquitination & Proteasome degradation"], "14063": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "140630": ["Antigen processing: Ubiquitination & Proteasome degradation"], "14064": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)"], "14065": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)"], "14066": ["Extrinsic Pathway of Fibrin Clot Formation"], "14067": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Post-translational protein phosphorylation"], "14068": ["Extrinsic Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "14069": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "COPII-mediated vesicle transport", "Cargo concentration in the ER"], "140709": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "14071": ["Extrinsic Pathway of Fibrin Clot Formation", "Intrinsic Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "140723": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "14073": ["Arachidonic acid metabolism"], "140740": ["XBP1(S) activates chaperone genes"], "140742": ["TP53 Regulates Metabolic Genes"], "14077": ["Triglyceride catabolism"], "14079": ["Triglyceride catabolism"], "140792": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Scavenging by Class A Receptors"], "140795": ["P2Y receptors", "G alpha (i) signalling events"], "14080": ["Triglyceride catabolism", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "140806": ["Interleukin-17 signaling"], "14081": ["alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "140810": ["Anchoring of the basal body to the plasma membrane"], "14082": ["Caspase activation via Death Receptors in the presence of ligand", "TRIF-mediated programmed cell death", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Dimerization of procaspase-8", "FasL/ CD95L signaling", "TRAIL  signaling"], "14083": ["Apoptotic cleavage of cellular proteins", "Regulation of actin dynamics for phagocytic cup formation", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "NCAM signaling for neurite out-growth", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "MET activates PTK2 signaling"], "14085": ["Phenylalanine and tyrosine catabolism"], "140858": ["PKMTs methylate histone lysines", "HATs acetylate histones", "RMTs methylate histone arginines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Neddylation"], "14087": ["Fanconi Anemia Pathway"], "14088": ["Fanconi Anemia Pathway"], "140917": ["Fanconi Anemia Pathway"], "140919": ["Organic anion transporters"], "14102": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "FasL/ CD95L signaling"], "14103": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "FasL/ CD95L signaling"], "14104": ["ChREBP activates metabolic gene expression", "Vitamin B5 (pantothenate) metabolism", "Fatty acyl-CoA biosynthesis"], "14106": ["Signaling by NODAL", "Signaling by Activin"], "14109": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "14113": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "14114": ["Molecules associated with elastic fibres"], "14115": ["Molecules associated with elastic fibres"], "14118": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "14119": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres"], "14120": ["Gluconeogenesis"], "14121": ["Gluconeogenesis"], "14125": ["Fc epsilon receptor (FCERI) signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation"], "14126": ["Fc epsilon receptor (FCERI) signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation"], "14127": ["GPVI-mediated activation cascade", "Cell surface interactions at the vascular wall", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Neutrophil degranulation", "Platelet Adhesion to exposed collagen"], "14129": ["Cross-presentation of soluble exogenous antigens (endosomes)", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis"], "14130": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "14131": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "14134": ["Neutrophil degranulation"], "14137": ["Cholesterol biosynthesis"], "14148": ["Mitochondrial iron-sulfur cluster biogenesis", "Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin"], "14149": ["Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin"], "14151": ["Heme biosynthesis"], "14154": ["Neddylation"], "14155": ["Neddylation"], "14156": ["POLB-Dependent Long Patch Base Excision Repair", "PCNA-Dependent Long Patch Base Excision Repair", "HDR through MMEJ (alt-NHEJ)", "Removal of the Flap Intermediate"], "14158": ["Signaling by SCF-KIT"], "14159": ["Signaling by SCF-KIT", "Sema3A PAK dependent Axon repulsion", "CRMPs in Sema3A signaling"], "14160": ["Regulation of FZD by ubiquitination"], "14161": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Regulation of TLR by endogenous ligand", "Post-translational protein phosphorylation"], "14163": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "14164": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR1b ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14165": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14166": ["Phase 0 - rapid depolarisation"], "14167": ["Phase 0 - rapid depolarisation"], "14168": ["Phase 0 - rapid depolarisation"], "14169": ["Phase 0 - rapid depolarisation"], "14170": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "FGFR4 ligand binding and activation", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14171": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14172": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14173": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR1b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14174": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14175": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14176": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14177": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14178": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14179": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14180": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14181": ["FGFR2b ligand binding and activation"], "14182": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR1c and Klotho ligand binding and activation", "Signal transduction by L1", "Phospholipase C-mediated cascade: FGFR1", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "Negative regulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14183": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14184": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "Phospholipase C-mediated cascade; FGFR3", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "Negative regulation of FGFR3 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14186": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "FGFR4 ligand binding and activation", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "14187": ["Estrogen biosynthesis", "Retinoid metabolism and transport"], "14190": ["Neutrophil degranulation"], "14191": ["FCGR activation", "Platelet sensitization by LDL", "Neutrophil degranulation"], "14194": ["Citric acid cycle (TCA cycle)"], "14204": ["Phenylalanine and tyrosine catabolism"], "14205": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "14211": ["Condensation of Prophase Chromosomes", "Condensation of Prometaphase Chromosomes"], "14218": ["Invadopodia formation"], "14225": ["TGF-beta receptor signaling activates SMADs"], "14226": ["Stimuli-sensing channels", "Ion homeostasis"], "14228": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "14229": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "ESR-mediated signaling"], "14232": ["Ub-specific processing proteases"], "14235": ["Polo-like kinase mediated events", "Cyclin A/B1/B2 associated events during G2/M transition"], "14245": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "14251": ["Synaptic adhesion-like molecules"], "14252": ["Synaptic adhesion-like molecules"], "14254": ["Neurophilin interactions with VEGF and VEGFR", "VEGF binds to VEGFR leading to receptor dimerization"], "14255": ["PI3K Cascade", "Other interleukin signaling", "RAF/MAP kinase cascade"], "14256": ["PI3K Cascade", "Other interleukin signaling", "RAF/MAP kinase cascade"], "14257": ["VEGF binds to VEGFR leading to receptor dimerization"], "14261": ["FMO oxidises nucleophiles"], "14262": ["FMO oxidises nucleophiles"], "14264": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "14268": ["Platelet degranulation ", "Degradation of the extracellular matrix", "Extracellular matrix organization", "Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "142681": ["Type II Na+/Pi cotransporters"], "142687": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "142688": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "14269": ["Clathrin-mediated endocytosis"], "14270": ["Rho GTPase cycle", "RHO GTPases Activate Formins"], "14272": ["Apoptotic cleavage of cellular proteins", "Inactivation, recovery and regulation of the phototransduction cascade"], "14275": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport"], "14276": ["Post-translational modification: synthesis of GPI-anchored proteins", "Metabolism of folate and pterines"], "14281": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "Activation of the AP-1 family of transcription factors", "Estrogen-dependent gene expression"], "14287": ["Metabolism of folate and pterines"], "14289": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "14290": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "14291": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "14293": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "Neutrophil degranulation"], "14294": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "14296": ["Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "14297": ["Mitochondrial protein import", "Mitochondrial iron-sulfur cluster biogenesis"], "142980": ["Trafficking and processing of endosomal TLR"], "14302": ["Neutrophil degranulation", "Regulation of PTEN stability and activity"], "14308": ["Glycoprotein hormones", "Hormone ligand-binding receptors", "G alpha (s) signalling events"], "14309": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "14311": ["Lipid particle organization"], "14312": ["RUNX3 regulates p14-ARF"], "14313": ["Antagonism of Activin by Follistatin"], "14314": ["Signaling by BMP", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "14317": ["Histidine catabolism"], "14325": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Iron uptake and transport"], "14357": ["Activated NOTCH1 Transmits Signal to the Nucleus"], "14360": ["GPVI-mediated activation cascade", "Signaling by ERBB2", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Cell surface interactions at the vascular wall", "FCGR activation", "PECAM1 interactions", "DAP12 signaling", "Nephrin family interactions", "NCAM signaling for neurite out-growth", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "CD209 (DC-SIGN) signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Platelet Adhesion to exposed collagen", "NTRK2 activates RAC1", "Regulation of signaling by CBL"], "14362": ["PCP/CE pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "14365": ["Ca2+ pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins"], "14366": ["Ca2+ pathway", "Asymmetric localization of PCP proteins", "Regulation of FZD by ubiquitination", "WNT5A-dependent internalization of FZD4", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "14367": ["Ca2+ pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "14368": ["Ca2+ pathway", "PCP/CE pathway", "Regulation of FZD by ubiquitination"], "14369": ["PCP/CE pathway", "Asymmetric localization of PCP proteins"], "14370": ["Asymmetric localization of PCP proteins", "Regulation of FZD by ubiquitination"], "14375": ["Nonhomologous End-Joining (NHEJ)", "Neutrophil degranulation"], "14377": ["Gluconeogenesis"], "14378": ["Gluconeogenesis"], "14380": ["TP53 Regulates Metabolic Genes", "Pentose phosphate pathway"], "14381": ["TP53 Regulates Metabolic Genes", "Pentose phosphate pathway"], "14387": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "14388": ["PI3K Cascade", "PIP3 activates AKT signaling", "GAB1 signalosome", "PI3K events in ERBB2 signaling", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "RET signaling", "MET activates PTPN11", "MET activates RAP1 and RAC1", "MET receptor recycling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "14390": ["Transcriptional activation of mitochondrial biogenesis"], "14391": ["Transcriptional activation of mitochondrial biogenesis"], "14394": ["GABA A receptor activation"], "14395": ["GABA A receptor activation"], "14396": ["GABA A receptor activation"], "14397": ["GABA A receptor activation"], "14399": ["GABA A receptor activation"], "14400": ["GABA A receptor activation"], "14401": ["GABA A receptor activation"], "14402": ["GABA A receptor activation"], "14406": ["GABA A receptor activation"], "14407": ["GABA A receptor activation"], "14408": ["GABA A (rho) receptor activation"], "14409": ["GABA A (rho) receptor activation"], "14411": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism", "Reuptake of GABA"], "14412": ["Na+/Cl- dependent neurotransmitter transporters", "Reuptake of GABA"], "14415": ["GABA synthesis", "GABA synthesis, release, reuptake and degradation"], "14417": ["GABA synthesis", "GABA synthesis, release, reuptake and degradation"], "14419": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "14420": ["Glycosphingolipid metabolism"], "14421": ["Glycosphingolipid metabolism"], "14422": ["Asparagine N-linked glycosylation"], "14423": ["COPI-independent Golgi-to-ER retrograde traffic", "O-linked glycosylation of mucins"], "14425": ["FGFR3c ligand binding and activation", "O-linked glycosylation of mucins"], "14426": ["O-linked glycosylation of mucins"], "14427": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "14428": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "14429": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "14430": ["Galactose catabolism"], "14431": ["Creatine metabolism"], "14432": ["L1CAM interactions"], "14447": ["Glycolysis"], "14450": ["Purine ribonucleoside monophosphate biosynthesis"], "14451": ["Ligand-receptor interactions", "Activation of SMO"], "14453": ["Caspase-mediated cleavage of cytoskeletal proteins"], "14456": ["Platelet degranulation ", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "14459": ["G alpha (q) signalling events", "Gastrin-CREB signalling pathway via PKC and MAPK"], "14460": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Factors involved in megakaryocyte development and platelet production"], "14461": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Factors involved in megakaryocyte development and platelet production"], "14462": ["Ub-specific processing proteases", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "14463": ["Factors involved in megakaryocyte development and platelet production"], "14464": ["Factors involved in megakaryocyte development and platelet production"], "14465": ["Surfactant metabolism", "Factors involved in megakaryocyte development and platelet production"], "14466": ["Glycosphingolipid metabolism"], "14473": ["Vitamin D (calciferol) metabolism"], "14479": ["Ub-specific processing proteases"], "14526": ["Glucagon signaling in metabolic regulation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events", "G alpha (s) signalling events", "Glucagon-type ligand receptors", "Synthesis, secretion, and deacylation of Ghrelin"], "14527": ["Glucagon signaling in metabolic regulation", "G alpha (q) signalling events", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "14528": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "14533": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "14534": ["NOTCH1 Intracellular Domain Regulates Transcription", "Notch-HLH transcription pathway", "B-WICH complex positively regulates rRNA expression", "Ub-specific processing proteases", "RUNX3 regulates NOTCH signaling"], "14536": ["Nuclear Receptor transcription pathway"], "14537": ["O-linked glycosylation of mucins"], "14539": ["The retinoid cycle in cones (daylight vision)", "G alpha (i) signalling events", "Opsins"], "14544": ["Purine catabolism"], "14548": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "14555": ["Synthesis of PA"], "14559": ["Sphingolipid de novo biosynthesis"], "14563": ["Molecules associated with elastic fibres"], "14567": ["Rho GTPase cycle", "RAB GEFs exchange GTP for GDP on RABs"], "14569": ["Rho GTPase cycle", "Neutrophil degranulation", "RAB GEFs exchange GTP for GDP on RABs"], "14570": ["Rho GTPase cycle"], "14571": ["Synthesis of PA", "Triglyceride catabolism"], "14573": ["RAF/MAP kinase cascade", "RET signaling"], "14583": ["Synthesis of UDP-N-acetyl-glucosamine"], "14584": ["Synthesis of UDP-N-acetyl-glucosamine"], "14585": ["RAF/MAP kinase cascade", "RET signaling"], "14586": ["RAF/MAP kinase cascade", "RET signaling"], "14587": ["RAF/MAP kinase cascade", "RET signaling"], "14588": ["RAF/MAP kinase cascade", "RET signaling"], "14590": ["Neutrophil degranulation"], "14593": ["Cholesterol biosynthesis"], "14595": ["Interaction With The Zona Pellucida", "Lactose synthesis", "Neutrophil degranulation", "N-Glycan antennae elongation"], "14598": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "14599": ["Prolactin receptor signaling", "Synthesis, secretion, and deacylation of Ghrelin", "Growth hormone receptor signaling"], "14600": ["Prolactin receptor signaling", "Growth hormone receptor signaling"], "14601": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "14602": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "14603": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "14605": ["Stimuli-sensing channels"], "14607": ["Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "14608": ["G alpha (s) signalling events"], "14609": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "Gap junction degradation", "c-src mediated regulation of Cx43 function and closure of gap junctions", "Formation of annular gap junctions"], "14610": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "14611": ["Gap junction assembly"], "14612": ["Gap junction assembly"], "14613": ["Gap junction assembly"], "14615": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "14616": ["Gap junction assembly"], "14617": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "14618": ["Oligomerization of connexins into connexons"], "14619": ["Transport of connexons to the plasma membrane"], "14620": ["Gap junction assembly"], "14621": ["Gap junction assembly"], "14622": ["Gap junction assembly"], "14623": ["Gap junction assembly"], "14626": ["Triglyceride biosynthesis"], "14628": ["Stimuli-sensing channels"], "14629": ["Glutathione synthesis and recycling"], "14630": ["Glutathione synthesis and recycling"], "14632": ["Degradation of GLI1 by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state"], "14633": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "14634": ["GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state"], "14635": ["Galactose catabolism"], "14645": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Amino acid synthesis and interconversion (transamination)"], "14651": ["Pyruvate metabolism"], "14652": ["Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "14654": ["Neurotransmitter receptors and postsynaptic signal transmission"], "14657": ["Neurotransmitter receptors and postsynaptic signal transmission"], "14658": ["Neurotransmitter receptors and postsynaptic signal transmission"], "14660": ["Glutamate Neurotransmitter Release Cycle", "TP53 Regulates Metabolic Genes", "Amino acid synthesis and interconversion (transamination)"], "14661": ["Transcriptional activation of mitochondrial biogenesis", "Amino acid synthesis and interconversion (transamination)"], "14664": ["Na+/Cl- dependent neurotransmitter transporters"], "14667": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "14672": ["Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "14673": ["G alpha (12/13) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)"], "14674": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Thromboxane signalling through TP receptor", "Thrombin signalling through proteinase activated receptors (PARs)"], "14675": ["Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "14676": ["Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "14677": ["PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "14678": ["PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "14679": ["PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "14680": ["Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Olfactory Signaling Pathway"], "14681": ["PLC beta mediated events", "G-protein activation", "Ca2+ pathway", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "14682": ["Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "14683": ["Glucagon signaling in metabolic regulation", "PKA activation in glucagon signalling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Prostacyclin signalling through prostacyclin receptor", "G alpha (s) signalling events", "Glucagon-type ligand receptors", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "14685": ["PLC beta mediated events", "G-protein activation", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "14686": ["PLC beta mediated events", "G-protein activation", "Ca2+ pathway", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "14687": ["PLC beta mediated events", "G-protein activation", "G alpha (z) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "14688": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Activation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Olfactory Signaling Pathway", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14693": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14694": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production"], "14695": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14696": ["Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "14697": ["G-protein activation", "Inactivation, recovery and regulation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "14699": ["Activation of G protein gated Potassium channels", "G-protein activation", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Olfactory Signaling Pathway", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14700": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14701": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14702": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14704": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14706": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14707": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14709": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14710": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "14711": ["Glyoxylate metabolism and glycine degradation"], "14712": ["Synthesis of PA", "Plasmalogen biosynthesis", "Peroxisomal protein import"], "14714": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "14715": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "14718": ["Amino acid synthesis and interconversion (transamination)"], "14719": ["Glyoxylate metabolism and glycine degradation", "Amino acid synthesis and interconversion (transamination)"], "14723": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "14724": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "14725": ["Vitamin D (calciferol) metabolism", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Retinoid metabolism and transport"], "14726": ["GPVI-mediated activation cascade"], "14727": ["Neutrophil degranulation"], "14728": ["Neutrophil degranulation"], "14729": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "14731": ["Attachment of GPI anchor to uPAR"], "14732": ["Synthesis of PA", "Triglyceride biosynthesis"], "14733": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Signaling by ROBO receptors", "Retinoid metabolism and transport"], "14734": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Retinoid metabolism and transport"], "14735": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Retinoid metabolism and transport"], "14739": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "14744": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "14745": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "14747": ["Class A/1 (Rhodopsin-like receptors)"], "14751": ["Neutrophil degranulation", "Glycolysis"], "14755": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "14756": ["Post-translational modification: synthesis of GPI-anchored proteins"], "14761": ["G alpha (s) signalling events"], "14763": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "14764": ["Prostanoid ligand receptors", "G alpha (i) signalling events"], "14767": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "14772": ["Inactivation, recovery and regulation of the phototransduction cascade"], "14773": ["G alpha (s) signalling events"], "14775": ["Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Detoxification of Reactive Oxygen Species", "Purine catabolism"], "14778": ["Detoxification of Reactive Oxygen Species"], "14780": ["Detoxification of Reactive Oxygen Species"], "14782": ["Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "TP53 Regulates Metabolic Genes"], "14783": ["Signaling by SCF-KIT", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "RET signaling"], "14784": ["PI3K Cascade", "SOS-mediated signalling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Spry regulation of FGF signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signalling to RAS", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Regulation of actin dynamics for phagocytic cup formation", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "NCAM signaling for neurite out-growth", "Costimulation by the CD28 family", "CD28 dependent Vav1 pathway", "Signal regulatory protein family interactions", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signal attenuation", "Insulin receptor signalling cascade", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "RET signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "MET activates PTPN11", "MET activates RAP1 and RAC1", "MET receptor recycling", "Interleukin-15 signaling", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "14786": ["GRB7 events in ERBB2 signaling", "Signaling by SCF-KIT", "Downstream signal transduction", "Tie2 Signaling", "RET signaling"], "14787": ["RHO GTPases Activate Rhotekin and Rhophilins"], "14789": ["Collagen biosynthesis and modifying enzymes"], "14791": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "14792": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE"], "14794": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "14799": ["COPII-mediated vesicle transport", "Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Cargo concentration in the ER", "Synaptic adhesion-like molecules"], "14802": ["Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Synaptic adhesion-like molecules"], "14805": ["Activation of Na-permeable kainate receptors", "Activation of Ca-permeable Kainate Receptor"], "14806": ["Activation of Na-permeable kainate receptors", "Activation of Ca-permeable Kainate Receptor"], "14807": ["Activation of Ca-permeable Kainate Receptor", "Presynaptic function of Kainate receptors"], "14809": ["Activation of Ca-permeable Kainate Receptor"], "14810": ["EPHB-mediated forward signaling", "Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade", "Synaptic adhesion-like molecules"], "14811": ["Unblocking of NMDA receptors, glutamate binding and activation", "Synaptic adhesion-like molecules"], "14812": ["EPHB-mediated forward signaling", "Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade", "Synaptic adhesion-like molecules"], "14813": ["Unblocking of NMDA receptors, glutamate binding and activation", "Synaptic adhesion-like molecules"], "14814": ["Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade", "Synaptic adhesion-like molecules"], "14815": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "14816": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "Neurexins and neuroligins"], "14823": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "14824": ["Neutrophil degranulation"], "14825": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "14827": ["ER-Phagosome pathway", "Calnexin/calreticulin cycle", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "14828": ["Regulation of HSF1-mediated heat shock response", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "14829": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "14852": ["Eukaryotic Translation Termination"], "14853": ["Eukaryotic Translation Termination"], "14854": ["Glutathione synthesis and recycling"], "14857": ["Glutathione conjugation"], "14858": ["Glutathione conjugation"], "14865": ["Glutathione conjugation", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "14866": ["Glutathione conjugation"], "14869": ["Glutathione conjugation", "Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "14870": ["Glutathione conjugation", "Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "14872": ["Glutathione conjugation"], "14873": ["Methylation", "Glutathione conjugation", "Vitamin C (ascorbate) metabolism"], "14874": ["Glutathione conjugation", "Regulation of pyruvate dehydrogenase (PDH) complex", "Phenylalanine and tyrosine catabolism"], "14884": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "14885": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "14897": ["Antigen processing: Ubiquitination & Proteasome degradation"], "14913": ["Inactivation, recovery and regulation of the phototransduction cascade"], "14915": ["Digestion"], "14916": ["Digestion"], "14917": ["Digestion"], "14919": ["Inactivation, recovery and regulation of the phototransduction cascade"], "14923": ["Interconversion of nucleotide di- and triphosphates"], "14933": ["Triglyceride biosynthesis"], "14936": ["Glycogen synthesis"], "14939": ["Activation, myristolyation of BID and translocation to mitochondria"], "14940": ["Activation, myristolyation of BID and translocation to mitochondria"], "14941": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "14942": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "14943": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "14944": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "14957": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "14958": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "14960": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling"], "14961": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling"], "14964": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "14969": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling"], "14972": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "14977": ["Zinc influx into cells by the SLC39 gene family"], "14979": ["Fatty acyl-CoA biosynthesis"], "14990": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "14991": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "14997": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "14998": ["MHC class II antigen presentation"], "14999": ["MHC class II antigen presentation"], "15000": ["MHC class II antigen presentation"], "15001": ["MHC class II antigen presentation"], "15002": ["MHC class II antigen presentation"], "15006": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "15007": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "15013": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "15015": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "15018": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "15040": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "15043": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "15077": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "15078": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "15081": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "15107": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "15108": ["Branched-chain amino acid catabolism"], "15109": ["Histidine catabolism"], "15112": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import"], "15116": ["Hyaluronan biosynthesis and export"], "15117": ["Hyaluronan biosynthesis and export"], "15118": ["Hyaluronan biosynthesis and export"], "15122": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma"], "15139": ["Terminal pathway of complement", "Activation of C3 and C5", "Peptide ligand-binding receptors", "G alpha (i) signalling events", "Regulation of Complement cascade"], "15160": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "15161": ["HATs acetylate histones", "UCH proteinases"], "15162": ["FCGR activation", "Regulation of signaling by CBL"], "15165": ["HCN channels"], "15166": ["HCN channels"], "15168": ["HCN channels"], "15170": ["GPVI-mediated activation cascade", "Regulation of KIT signaling", "PECAM1 interactions", "Costimulation by the CD28 family", "PD-1 signaling", "Platelet sensitization by LDL", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "CD22 mediated BCR regulation", "Neutrophil degranulation", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Interleukin receptor SHC signaling", "Regulation of IFNA signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "15171": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "15182": ["HDACs deacetylate histones", "SUMOylation of chromatin organization proteins", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of MECP2 expression and activity", "Factors involved in megakaryocyte development and platelet production"], "15183": ["HDACs deacetylate histones", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "15185": ["HSF1 activation", "Cilium Assembly"], "15186": ["Histidine catabolism"], "15199": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "15200": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "EGFR Transactivation by Gastrin", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "PTK6 promotes HIF1A stabilization", "Downregulation of ERBB2 signaling"], "15203": ["Metal ion SLC transporters", "Iron uptake and transport"], "15204": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "Antigen processing: Ubiquitination & Proteasome degradation"], "15211": ["Glycosphingolipid metabolism"], "15212": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "15216": ["Transferrin endocytosis and recycling"], "15228": ["FOXO-mediated transcription of cell cycle genes"], "15233": ["Phenylalanine and tyrosine catabolism"], "15234": ["Platelet degranulation ", "PIP3 activates AKT signaling", "RAF/MAP kinase cascade", "MET Receptor Activation", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "MET activates PTPN11", "MET activates PTK2 signaling", "MET interacts with TNS proteins", "MET activates RAP1 and RAC1", "MET receptor recycling", "MET activates STAT3"], "15239": ["EGFR downregulation", "Lysosome Vesicle Biogenesis", "Ub-specific processing proteases", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "15245": ["Ligand-receptor interactions"], "15248": ["SUMOylation of transcription factors"], "15251": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Ub-specific processing proteases", "PTK6 promotes HIF1A stabilization", "Neddylation"], "15257": ["Regulation of TP53 Activity through Phosphorylation"], "15258": ["SUMOylation of transcription cofactors", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "15260": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "15267": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "15270": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "15275": ["Glycolysis"], "15277": ["Glycolysis"], "15278": ["Mitochondrial transcription initiation"], "15288": ["Heme biosynthesis"], "15312": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "15353": ["HDACs deacetylate histones", "Factors involved in megakaryocyte development and platelet production"], "15356": ["Synthesis of Ketone Bodies", "Peroxisomal protein import"], "15357": ["Cholesterol biosynthesis"], "15360": ["Synthesis of Ketone Bodies"], "15361": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "15364": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "15366": ["Hyaluronan uptake and degradation", "AURKA Activation by TPX2"], "15368": ["Heme degradation", "Iron uptake and transport"], "15369": ["Heme degradation", "Neutrophil degranulation", "Iron uptake and transport"], "15370": ["AKT phosphorylates targets in the nucleus", "Nuclear Receptor transcription pathway"], "15375": ["Estrogen-dependent gene expression"], "15378": ["Nuclear Receptor transcription pathway"], "15381": ["SUMOylation of RNA binding proteins", "mRNA Splicing - Major Pathway"], "15387": ["SUMOylation of RNA binding proteins", "mRNA Splicing - Major Pathway"], "15388": ["mRNA Splicing - Major Pathway"], "15439": ["Scavenging of heme from plasma", "Neutrophil degranulation"], "15442": ["HS-GAG degradation", "Neutrophil degranulation"], "15445": ["Phenylalanine and tyrosine catabolism"], "15446": ["Synthesis of Lipoxins (LX)"], "15450": ["Assembly of active LPL and LIPC lipase complexes", "Chylomicron clearance"], "15451": ["MET Receptor Activation"], "15452": ["Purine salvage"], "15458": ["Scavenging of heme from plasma"], "15461": ["Activation of RAS in B cells", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "EPHB-mediated forward signaling", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling"], "15463": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "15464": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "15465": ["Histamine receptors", "G alpha (q) signalling events"], "15466": ["Histamine receptors", "G alpha (s) signalling events"], "15469": ["RMTs methylate histone arginines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "15473": ["Threonine catabolism"], "15476": ["HS-GAG biosynthesis"], "15478": ["HS-GAG biosynthesis"], "15482": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation"], "15483": ["Glucocorticoid biosynthesis"], "15484": ["Glucocorticoid biosynthesis"], "15485": ["Estrogen biosynthesis"], "15486": ["Estrogen biosynthesis"], "15487": ["Androgen biosynthesis", "Synthesis of very long-chain fatty acyl-CoAs"], "15488": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import"], "15490": ["Cholesterol biosynthesis"], "15492": ["Mineralocorticoid biosynthesis"], "15493": ["Mineralocorticoid biosynthesis"], "15494": ["Mineralocorticoid biosynthesis"], "15495": ["Mineralocorticoid biosynthesis"], "15496": ["Mineralocorticoid biosynthesis"], "15497": ["Mineralocorticoid biosynthesis"], "15499": ["Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation"], "15505": ["Regulation of HSF1-mediated heat shock response"], "15507": ["VEGFA-VEGFR2 Pathway", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "MAPK6/MAPK4 signaling"], "15511": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Neutrophil degranulation"], "15512": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase"], "15516": ["Regulation of actin dynamics for phagocytic cup formation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation", "Sema3A PAK dependent Axon repulsion", "Neutrophil degranulation", "The NLRP3 inflammasome", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Aryl hydrocarbon receptor signalling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "15519": ["Signaling by ERBB2", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "Regulation of actin dynamics for phagocytic cup formation", "eNOS activation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Sema3A PAK dependent Axon repulsion", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Downregulation of ERBB2 signaling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "15525": ["Regulation of HSF1-mediated heat shock response"], "15526": ["Regulation of HSF1-mediated heat shock response"], "15529": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "EPHB-mediated forward signaling", "Post-translational protein phosphorylation", "Retinoid metabolism and transport"], "15530": ["Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Integrin cell surface interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Retinoid metabolism and transport"], "15531": ["HS-GAG biosynthesis"], "15550": ["Serotonin receptors", "G alpha (i) signalling events"], "15551": ["Serotonin receptors", "G alpha (i) signalling events"], "15552": ["Serotonin receptors", "G alpha (i) signalling events"], "15557": ["Serotonin receptors", "G alpha (i) signalling events"], "15558": ["Serotonin receptors", "G alpha (q) signalling events"], "15559": ["Serotonin receptors", "G alpha (q) signalling events"], "15560": ["Serotonin receptors", "G alpha (q) signalling events"], "15561": ["Neurotransmitter receptors and postsynaptic signal transmission"], "15562": ["Serotonin receptors", "G alpha (s) signalling events"], "15563": ["Serotonin receptors", "G alpha (i) signalling events"], "15565": ["Serotonin receptors", "G alpha (s) signalling events"], "15566": ["Serotonin receptors", "G alpha (s) signalling events"], "15567": ["Serotonin clearance from the synaptic cleft"], "15568": ["HuR (ELAVL1) binds and stabilizes mRNA", "mRNA Splicing - Major Pathway"], "15569": ["mRNA Splicing - Major Pathway"], "15574": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "15586": ["CS/DS degradation"], "15587": ["Hyaluronan uptake and degradation"], "15874": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "15891": ["Integrin cell surface interactions"], "15894": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "15896": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "CD209 (DC-SIGN) signaling"], "15898": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "15926": ["NADPH regeneration", "Neutrophil degranulation", "Peroxisomal protein import"], "15929": ["Citric acid cycle (TCA cycle)"], "15930": ["Tryptophan catabolism"], "15931": ["HS-GAG degradation"], "15932": ["HS-GAG degradation"], "15937": ["PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "15945": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "15951": ["Neutrophil degranulation"], "15962": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15964": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15965": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15967": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15968": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15969": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15970": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15972": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15974": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15975": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15976": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15977": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "15978": ["Interferon gamma signaling", "Regulation of IFNG signaling"], "15979": ["Interferon gamma signaling", "Regulation of IFNG signaling"], "15980": ["Interferon gamma signaling", "Regulation of IFNG signaling"], "15985": ["CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "16000": ["Platelet degranulation ", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Synthesis, secretion, and deacylation of Ghrelin"], "16001": ["Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R"], "16002": ["Platelet degranulation ", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "16004": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "16005": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "16006": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "16007": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "16008": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "16009": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "TP53 Regulates Transcription of Death Receptors and Ligands", "Post-translational protein phosphorylation"], "16010": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "16011": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "16012": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "16068": ["Interleukin-18 signaling"], "16069": ["Cell surface interactions at the vascular wall", "Scavenging of heme from plasma"], "16136": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "16147": ["Hedgehog ligand biogenesis", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Activation of SMO"], "16149": ["Cell surface interactions at the vascular wall", "MHC class II antigen presentation"], "16150": ["Activation of NF-kappaB in B cells", "NOD1/2 Signaling Pathway", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "16151": ["Activation of NF-kappaB in B cells", "NOD1/2 Signaling Pathway", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "SUMOylation of immune response proteins", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "16153": ["Interleukin-10 signaling"], "16154": ["Interleukin-10 signaling"], "16155": ["Interleukin-10 signaling", "Interleukin-20 family signaling"], "16156": ["IL-6-type cytokine receptor ligand interactions"], "16157": ["IL-6-type cytokine receptor ligand interactions"], "16158": ["IL-6-type cytokine receptor ligand interactions"], "16159": ["Interleukin-35 Signalling", "Interleukin-12 signaling"], "16160": ["Interleukin-12 signaling", "Interleukin-23 signaling"], "16161": ["Interleukin-12 signaling", "Interleukin-23 signaling"], "16162": ["Interleukin-35 Signalling", "Interleukin-12 signaling"], "16163": ["Interleukin-4 and Interleukin-13 signaling"], "16164": ["Interleukin-4 and Interleukin-13 signaling"], "16165": ["Interleukin-4 and Interleukin-13 signaling"], "16168": ["Interleukin-15 signaling"], "16169": ["Interleukin-15 signaling"], "16170": ["Other interleukin signaling"], "16171": ["Interleukin-17 signaling"], "16172": ["Interleukin-17 signaling"], "16173": ["Interleukin-1 processing", "Interleukin-18 signaling"], "16174": ["Interleukin-18 signaling"], "16175": ["Interleukin-1 processing", "Interleukin-1 signaling"], "16176": ["Interleukin-1 processing", "CLEC7A/inflammasome pathway", "Interleukin-1 signaling"], "16177": ["Interleukin-1 signaling"], "16178": ["Interleukin-1 signaling"], "16179": ["PIP3 activates AKT signaling", "NOD1/2 Signaling Pathway", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "MyD88 dependent cascade initiated on endosome"], "16180": ["PIP3 activates AKT signaling", "Receptor-type tyrosine-protein phosphatases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-36 pathway", "Interleukin-33 signaling", "Interleukin-1 signaling"], "16181": ["Interleukin-1 signaling"], "16182": ["Interleukin-18 signaling"], "16183": ["RAF/MAP kinase cascade", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "16184": ["RAF/MAP kinase cascade", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "16185": ["RAF/MAP kinase cascade", "Interleukin-15 signaling", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "16186": ["Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Interleukin receptor SHC signaling"], "16188": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "16189": ["Interleukin-4 and Interleukin-13 signaling"], "16190": ["Interleukin-4 and Interleukin-13 signaling"], "16191": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "16192": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "16193": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "16194": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation"], "16195": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "IL-6-type cytokine receptor ligand interactions", "Interleukin-35 Signalling", "Interleukin-27 signaling"], "16196": ["Interleukin-7 signaling"], "16197": ["Interleukin-7 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "16198": ["Interleukin-9 signaling"], "16199": ["Interleukin-9 signaling"], "16202": ["Localization of the PINCH-ILK-PARVIN complex to focal adhesions"], "16204": ["Recycling of bile acids and salts", "Triglyceride catabolism"], "16206": ["Signaling by EGFR", "Negative regulation of MET activity"], "16211": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Activation of DNA fragmentation factor", "Neutrophil degranulation"], "16319": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "16322": ["Glycoprotein hormones"], "16323": ["Signaling by Activin", "Glycoprotein hormones", "Antagonism of Activin by Follistatin"], "16324": ["Signaling by Activin", "Glycoprotein hormones", "Antagonism of Activin by Follistatin"], "16325": ["Glycoprotein hormones"], "16326": ["Glycoprotein hormones"], "16328": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "16329": ["Synthesis of IP2, IP, and Ins in the cytosol"], "16330": ["Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Rho GTPase cycle"], "16331": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Downstream TCR signaling", "PECAM1 interactions", "Interleukin receptor SHC signaling"], "16332": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Interleukin receptor SHC signaling"], "16333": ["Insulin processing", "Synthesis, secretion, and deacylation of Ghrelin", "COPI-mediated anterograde transport", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling"], "16334": ["Insulin processing", "Synthesis, secretion, and deacylation of Ghrelin", "COPI-mediated anterograde transport", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling"], "16336": ["G alpha (s) signalling events", "Relaxin receptors"], "16337": ["PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling"], "16341": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "16367": ["PI3K Cascade", "IRS-mediated signalling", "SOS-mediated signalling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "PI3K/AKT activation", "IRS-related events triggered by IGF1R", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation"], "16370": ["IRS-related events triggered by IGF1R"], "16391": ["Interferon alpha/beta signaling"], "16396": ["Downregulation of ERBB4 signaling", "NOD1/2 Signaling Pathway", "Activated NOTCH1 Transmits Signal to the Nucleus", "Degradation of GLI1 by the proteasome", "Hedgehog 'on' state", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Antigen processing: Ubiquitination & Proteasome degradation"], "16398": ["Integrin cell surface interactions", "Laminin interactions", "Syndecan interactions", "ECM proteoglycans", "MET activates PTK2 signaling"], "16399": ["Platelet degranulation ", "Integrin cell surface interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Signal transduction by L1", "MAP2K and MAPK activation"], "16400": ["Basigin interactions", "Integrin cell surface interactions", "Laminin interactions", "MET activates PTK2 signaling"], "16401": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions"], "16402": ["Elastic fibre formation", "Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Signal transduction by L1"], "16403": ["Assembly of collagen fibrils and other multimeric structures", "Basigin interactions", "Integrin cell surface interactions", "Laminin interactions", "Syndecan interactions", "Type I hemidesmosome assembly"], "16404": ["Laminin interactions", "ECM proteoglycans"], "16407": ["Integrin cell surface interactions"], "16409": ["Toll Like Receptor 4 (TLR4) Cascade", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Neutrophil degranulation"], "16410": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Elastic fibre formation", "PECAM1 interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "ECM proteoglycans", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "Neutrophil degranulation"], "16411": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "ECM proteoglycans", "Neutrophil degranulation"], "16412": ["Elastic fibre formation", "Fibronectin matrix formation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Basigin interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Laminin interactions", "Syndecan interactions", "ECM proteoglycans", "Signal transduction by L1", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "MET activates PTK2 signaling", "MET interacts with TNS proteins"], "16414": ["Toll Like Receptor 4 (TLR4) Cascade", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Neutrophil degranulation"], "16415": ["Toll Like Receptor 4 (TLR4) Cascade", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Neutrophil degranulation"], "16416": ["Platelet degranulation ", "Elastic fibre formation", "PECAM1 interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "MAP2K and MAPK activation"], "16419": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "ECM proteoglycans", "Smooth Muscle Contraction"], "16420": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "ECM proteoglycans"], "16421": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "16423": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "16425": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "16426": ["Platelet degranulation "], "16427": ["Platelet degranulation "], "16428": ["Generation of second messenger molecules", "FCERI mediated Ca+2 mobilization"], "16429": ["Antimicrobial peptides"], "16434": ["Purine catabolism"], "16438": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "cGMP effects", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "16439": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "16440": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "16443": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "16447": ["Formation of the cornified envelope"], "16449": ["NOTCH3 Activation and Transmission of Signal to the Nucleus"], "16450": ["Activated NOTCH1 Transmits Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "16451": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "ISG15 antiviral mechanism", "Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-12 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling", "Interferon alpha/beta signaling", "Interleukin receptor SHC signaling", "Regulation of IFNA signaling"], "16452": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Prolactin receptor signaling", "Signaling by SCF-KIT", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF activation", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Cyclin D associated events in G1", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS", "Interleukin receptor SHC signaling", "Growth hormone receptor signaling", "Factors involved in megakaryocyte development and platelet production"], "16453": ["Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Interleukin receptor SHC signaling"], "16456": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions"], "16468": ["PRC2 methylates histones and DNA"], "16475": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Regulation of PLK1 Activity at G2/M Transition"], "16476": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "Activation of the AP-1 family of transcription factors", "Estrogen-dependent gene expression"], "16480": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "16485": ["Voltage gated Potassium channels"], "16490": ["Voltage gated Potassium channels"], "16491": ["Voltage gated Potassium channels"], "16492": ["Voltage gated Potassium channels"], "16493": ["Voltage gated Potassium channels"], "16494": ["Voltage gated Potassium channels"], "16495": ["Voltage gated Potassium channels"], "16497": ["Voltage gated Potassium channels"], "16498": ["Voltage gated Potassium channels", "Neutrophil degranulation"], "16499": ["Voltage gated Potassium channels"], "16500": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "16502": ["Voltage gated Potassium channels"], "16504": ["Voltage gated Potassium channels"], "16506": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "16508": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "16509": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "16510": ["Voltage gated Potassium channels"], "16511": ["Voltage gated Potassium channels", "Phase 3 - rapid repolarisation"], "16512": ["Voltage gated Potassium channels"], "16513": ["Activation of G protein gated Potassium channels", "Potassium transport channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16514": ["ATP sensitive Potassium channels", "ABC-family proteins mediated transport", "Regulation of insulin secretion", "Ion homeostasis"], "16515": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16516": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16517": ["Activation of G protein gated Potassium channels", "Potassium transport channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16518": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16519": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16520": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16521": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16522": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16523": ["ATP sensitive Potassium channels"], "16524": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "16525": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "16526": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "16527": ["TWIK-releated acid-sensitive K+ channel (TASK)", "Phase 4 - resting membrane potential"], "16528": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "16529": ["Phase 4 - resting membrane potential"], "16530": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "16531": ["Ca2+ activated K+ channels"], "16532": ["Sperm Motility And Taxes"], "16533": ["Ca2+ activated K+ channels"], "16534": ["Ca2+ activated K+ channels"], "16535": ["Voltage gated Potassium channels", "Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "16536": ["Voltage gated Potassium channels"], "16538": ["Voltage gated Potassium channels"], "16539": ["Voltage gated Potassium channels"], "16541": ["Surfactant metabolism"], "16542": ["Neurophilin interactions with VEGF and VEGFR", "VEGF binds to VEGFR leading to receptor dimerization", "Integrin cell surface interactions", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated cell proliferation"], "16545": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "16548": ["Fructose catabolism"], "16549": ["KSRP (KHSRP) binds and destabilizes mRNA"], "16551": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16552": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16554": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16558": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16559": ["Intraflagellar transport"], "16560": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16561": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16562": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16563": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "16564": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16565": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16568": ["MHC class II antigen presentation", "Hedgehog 'off' state", "Intraflagellar transport", "Activation of SMO", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16569": ["MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16570": ["MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16571": ["MHC class II antigen presentation", "Recycling pathway of L1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16572": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16573": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16576": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "16578": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16579": ["MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16580": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16581": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16588": ["Protein methylation"], "16590": ["PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "16591": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1c and Klotho ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "Negative regulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "16592": ["Triglyceride catabolism", "Signaling by Retinoic Acid", "Neutrophil degranulation"], "16593": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16594": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "16621": ["Intrinsic Pathway of Fibrin Clot Formation", "Activation of Matrix Metalloproteinases"], "16625": ["Platelet degranulation ", "Neutrophil degranulation"], "16641": ["DAP12 interactions", "DAP12 signaling"], "16642": ["DAP12 interactions", "DAP12 signaling"], "16643": ["DAP12 interactions", "DAP12 signaling"], "16644": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "G alpha (i) signalling events", "Post-translational protein phosphorylation"], "16646": ["Activation of DNA fragmentation factor"], "16647": ["Sensing of DNA Double Strand Breaks"], "16653": ["Activation of RAS in B cells", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling", "RUNX3 regulates p14-ARF"], "16660": ["Keratinization", "Formation of the cornified envelope"], "16661": ["Keratinization", "Formation of the cornified envelope"], "16663": ["Keratinization", "Formation of the cornified envelope"], "16664": ["Type I hemidesmosome assembly", "Keratinization", "Formation of the cornified envelope"], "16665": ["Keratinization", "Formation of the cornified envelope"], "16666": ["Keratinization", "Formation of the cornified envelope"], "16667": ["Keratinization", "Formation of the cornified envelope"], "16668": ["Keratinization", "Formation of the cornified envelope"], "16669": ["Keratinization", "Formation of the cornified envelope"], "16670": ["Keratinization", "Formation of the cornified envelope"], "16671": ["Keratinization", "Formation of the cornified envelope"], "16672": ["Keratinization", "Formation of the cornified envelope"], "16673": ["Keratinization", "Formation of the cornified envelope"], "16675": ["Keratinization", "Formation of the cornified envelope"], "16678": ["Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "16679": ["Keratinization", "Formation of the cornified envelope"], "16680": ["Keratinization", "Formation of the cornified envelope"], "16681": ["Keratinization", "Formation of the cornified envelope"], "16682": ["Keratinization", "Formation of the cornified envelope"], "16687": ["Keratinization", "Formation of the cornified envelope"], "16688": ["Keratinization", "Formation of the cornified envelope"], "16691": ["Keratinization", "Formation of the cornified envelope"], "16693": ["Keratinization"], "16694": ["Keratinization"], "16699": ["Keratinization"], "16703": ["Keratinization"], "16705": ["Keratinization"], "16706": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway"], "16709": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RHO GTPases activate KTN1", "Post-translational protein phosphorylation"], "16728": ["Basigin interactions", "L1CAM interactions", "Recycling pathway of L1", "Interaction between L1 and Ankyrins", "Signal transduction by L1"], "16768": ["MHC class II antigen presentation"], "16769": ["Keratinization", "Formation of the cornified envelope"], "16770": ["Lactose synthesis"], "16772": ["Laminin interactions", "MET activates PTK2 signaling"], "16773": ["Laminin interactions", "MET activates PTK2 signaling"], "16774": ["Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "16775": ["Laminin interactions", "MET activates PTK2 signaling"], "16776": ["Laminin interactions", "MET activates PTK2 signaling"], "16777": ["Laminin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "16779": ["Laminin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "16780": ["Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "16782": ["Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "16783": ["Neutrophil degranulation"], "16784": ["Platelet degranulation ", "Neutrophil degranulation"], "16790": ["Neutrophil degranulation"], "16795": ["O-linked glycosylation"], "16797": ["GPVI-mediated activation cascade", "Generation of second messenger molecules", "DAP12 signaling", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "RAF/MAP kinase cascade"], "16798": ["Signaling by Hippo"], "16800": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "16801": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "16803": ["Toll Like Receptor 4 (TLR4) Cascade", "Transfer of LPS from LBP carrier to CD14", "Regulation of TLR by endogenous ligand"], "16816": ["HDL remodeling"], "16818": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PECAM1 interactions", "DAP12 signaling", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "PD-1 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-2 signaling"], "16820": ["Transport of fatty acids"], "16822": ["GPVI-mediated activation cascade", "Generation of second messenger molecules", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization"], "16825": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "16828": ["Pyruvate metabolism"], "16832": ["Pyruvate metabolism"], "16833": ["Pyruvate metabolism"], "16834": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "16835": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Chylomicron clearance", "LDL clearance"], "16842": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "16846": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and deacylation of Ghrelin"], "16852": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "16854": ["Neutrophil degranulation"], "16866": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glycoprotein hormones", "Hormone ligand-binding receptors", "G alpha (s) signalling events", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Reactions specific to the complex N-glycan synthesis pathway"], "16867": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "16878": ["IL-6-type cytokine receptor ligand interactions"], "16880": ["IL-6-type cytokine receptor ligand interactions"], "16881": ["POLB-Dependent Long Patch Base Excision Repair", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Processive synthesis on the lagging strand"], "16882": ["Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "HDR through MMEJ (alt-NHEJ)", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "16885": ["Regulation of actin dynamics for phagocytic cup formation", "Sema3A PAK dependent Axon repulsion", "RHO GTPases activate PAKs"], "16889": ["LDL clearance"], "16891": ["HDL remodeling"], "16898": ["L13a-mediated translational silencing of Ceruloplasmin expression", "RMTs methylate histone arginines", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "Protein methylation"], "16904": ["Alternative complement activation"], "16905": ["Breakdown of the nuclear lamina", "Depolymerisation of the Nuclear Lamina"], "16906": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "Breakdown of the nuclear lamina", "Depolymerisation of the Nuclear Lamina"], "16909": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "16912": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "16913": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "16922": ["Alpha-oxidation of phytanate", "Peroxisomal protein import"], "16923": ["Regulation of KIT signaling", "Factors involved in megakaryocyte development and platelet production"], "16924": ["Antigen processing: Ubiquitination & Proteasome degradation"], "16948": ["Crosslinking of collagen fibrils"], "16949": ["Crosslinking of collagen fibrils"], "16950": ["Crosslinking of collagen fibrils"], "16952": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "16956": ["Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling"], "16963": ["Chemokine receptors bind chemokines", "G alpha (q) signalling events"], "16970": ["Neutrophil degranulation"], "16971": ["Scavenging of heme from plasma", "Retinoid metabolism and transport"], "16973": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination"], "16974": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination"], "16975": ["Platelet sensitization by LDL", "Retinoid metabolism and transport"], "16987": ["Cholesterol biosynthesis"], "16992": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "16993": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Neutrophil degranulation", "Biosynthesis of E-series 18(S)-resolvins"], "16994": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "16995": ["Leukotriene receptors", "G alpha (q) signalling events"], "16997": ["Molecules associated with elastic fibres"], "16998": ["Molecules associated with elastic fibres"], "17000": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "17001": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "17002": ["Neutrophil degranulation", "Metal sequestration by antimicrobial proteins", "Antimicrobial peptides"], "17022": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Integrin cell surface interactions"], "17025": ["Heme biosynthesis", "Neutrophil degranulation"], "170439": ["Synthesis of very long-chain fatty acyl-CoAs"], "170441": ["Cellular hexose transport"], "170442": ["Carnitine synthesis"], "170458": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "170459": ["Pregnenolone biosynthesis"], "170460": ["Recycling of bile acids and salts"], "170461": ["Pregnenolone biosynthesis"], "170484": ["Nephrin family interactions"], "17060": ["Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "170625": ["Clathrin-mediated endocytosis"], "17063": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "170639": ["Olfactory Signaling Pathway"], "17064": ["Neutrophil degranulation"], "170643": ["Nephrin family interactions"], "170644": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "17068": ["Post-translational modification: synthesis of GPI-anchored proteins"], "17069": ["Post-translational modification: synthesis of GPI-anchored proteins"], "170707": ["Ub-specific processing proteases"], "170711": ["Ovarian tumor domain proteases"], "170716": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "170718": ["Citric acid cycle (TCA cycle)"], "170722": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "170725": ["Degradation of the extracellular matrix"], "170731": ["Pink/Parkin Mediated Mitophagy", "Factors involved in megakaryocyte development and platelet production"], "170736": ["Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "170737": ["Antigen processing: Ubiquitination & Proteasome degradation"], "170738": ["Voltage gated Potassium channels"], "170740": ["Generic Transcription Pathway"], "170741": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "170743": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 7/8 (TLR7/8) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "170744": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 7/8 (TLR7/8) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "170745": ["Post-translational modification: synthesis of GPI-anchored proteins"], "170749": ["Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Downregulation of TGF-beta receptor signaling"], "17075": ["Cell surface interactions at the vascular wall"], "170752": ["Retinoid metabolism and transport"], "170753": ["Generic Transcription Pathway"], "170755": ["Stimuli-sensing channels"], "170756": ["Sodium/Calcium exchangers", "Mitochondrial calcium ion transport"], "170758": ["Rho GTPase cycle", "PCP/CE pathway"], "170759": ["Ion transport by P-type ATPases"], "170760": ["Golgi Associated Vesicle Biogenesis"], "170762": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "170768": ["Glycolysis"], "170771": ["PTK6 Regulates Proteins Involved in RNA Processing"], "170779": ["CD209 (DC-SIGN) signaling", "Butyrophilin (BTN) family interactions"], "170780": ["CD209 (DC-SIGN) signaling", "Butyrophilin (BTN) family interactions"], "170786": ["CD209 (DC-SIGN) signaling", "Butyrophilin (BTN) family interactions"], "170787": ["HDACs deacetylate histones"], "170789": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "17079": ["Toll Like Receptor 4 (TLR4) Cascade"], "170813": ["Neutrophil degranulation"], "17082": ["PIP3 activates AKT signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-33 signaling"], "170822": ["Ub-specific processing proteases", "Regulation of expression of SLITs and ROBOs"], "170823": ["Antigen processing: Ubiquitination & Proteasome degradation"], "170835": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol"], "17084": ["Toll Like Receptor 4 (TLR4) Cascade"], "17087": ["Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "Regulation of TLR by endogenous ligand", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "170930": ["Vitamin D (calciferol) metabolism", "SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER"], "170936": ["Generic Transcription Pathway"], "17096": ["GPVI-mediated activation cascade", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Cell surface interactions at the vascular wall", "FCGR activation", "PECAM1 interactions", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "CD209 (DC-SIGN) signaling", "CD22 mediated BCR regulation", "Cyclin D associated events in G1", "Platelet Adhesion to exposed collagen", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS", "Regulation of signaling by CBL", "Growth hormone receptor signaling"], "171095": ["Interleukin-17 signaling"], "17113": ["Lysosome Vesicle Biogenesis", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "171166": ["TRP channels"], "171168": ["Sphingolipid de novo biosynthesis"], "17117": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Peroxisomal protein import"], "171171": ["Post-translational modification: synthesis of GPI-anchored proteins"], "17118": ["Acetylcholine regulates insulin secretion"], "17120": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "171207": ["Rho GTPase cycle"], "171209": ["Stimuli-sensing channels"], "171210": ["Mitochondrial Fatty Acid Beta-Oxidation", "Peroxisomal protein import"], "171211": ["TNFs bind their physiological receptors"], "171212": ["O-linked glycosylation of mucins"], "17123": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "17126": ["Signaling by NODAL", "Signaling by Activin", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Ub-specific processing proteases", "FOXO-mediated transcription of cell cycle genes"], "17127": ["Signaling by NODAL", "Signaling by Activin", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Ub-specific processing proteases", "RUNX3 regulates CDKN1A transcription", "FOXO-mediated transcription of cell cycle genes"], "17128": ["Signaling by NODAL", "Signaling by Activin", "Signaling by BMP", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Ub-specific processing proteases", "RUNX3 regulates CDKN1A transcription", "FOXO-mediated transcription of cell cycle genes"], "171281": ["Mitochondrial Fatty Acid Beta-Oxidation", "Peroxisomal protein import"], "171282": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "17129": ["Signaling by BMP"], "17130": ["Signaling by BMP"], "17131": ["Signaling by BMP", "Downregulation of TGF-beta receptor signaling", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Ub-specific processing proteases"], "17133": ["Factors involved in megakaryocyte development and platelet production"], "17134": ["Factors involved in megakaryocyte development and platelet production"], "17135": ["Factors involved in megakaryocyte development and platelet production"], "17136": ["Axonal growth inhibition (RHOA activation)", "Basigin interactions"], "171382": ["TRP channels"], "171463": ["MAP2K and MAPK activation"], "171469": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "17149": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "17150": ["Elastic fibre formation", "Molecules associated with elastic fibres"], "171504": ["VLDL clearance"], "171530": ["Class B/2 (Secretin family receptors)"], "171543": ["BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation of BMF and translocation to mitochondria"], "17155": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "17156": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "171567": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "17158": ["Intra-Golgi traffic", "Reactions specific to the complex N-glycan synthesis pathway"], "171580": ["Factors involved in megakaryocyte development and platelet production"], "17159": ["Neutrophil degranulation", "Lysosomal oligosaccharide catabolism"], "17160": ["Lysosomal oligosaccharide catabolism"], "17161": ["Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "Metabolism of serotonin"], "17164": ["p38MAPK events", "CREB phosphorylation", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Oxidative Stress Induced Senescence", "Regulation of HSF1-mediated heat shock response", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation"], "17165": ["Oxidative Stress Induced Senescence", "MAPK6/MAPK4 signaling", "Regulation of TP53 Activity through Phosphorylation"], "17167": ["Scavenging by Class A Receptors"], "17169": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway"], "17175": ["Lectin pathway of complement activation", "Initial triggering of complement"], "17178": ["Ion homeostasis", "Ion transport by P-type ATPases"], "17179": ["Downregulation of ERBB2 signaling"], "17180": ["ECM proteoglycans"], "17182": ["ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "17183": ["ECM proteoglycans"], "17187": ["Transcriptional Regulation by E2F6"], "17189": ["Intracellular oxygen transport"], "17190": ["SUMOylation of transcription cofactors"], "17191": ["NoRC negatively regulates rRNA expression", "RNA Polymerase I Promoter Opening"], "17192": ["HDACs deacetylate histones", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "17193": ["Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "17200": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "17201": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "17202": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "17203": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "17207": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "17215": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "17216": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "17217": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "17218": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "17219": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "17220": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "17221": ["Regulation of Complement cascade"], "17222": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "17228": ["Signaling by SCF-KIT", "Activation of Matrix Metalloproteinases", "Metabolism of Angiotensinogen to Angiotensins"], "17229": ["Activation of Matrix Metalloproteinases"], "17237": ["Antigen processing: Ubiquitination & Proteasome degradation"], "17242": ["NOTCH2 Activation and Transmission of Signal to the Nucleus"], "17246": ["AKT phosphorylates targets in the cytosol", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "SUMOylation of ubiquitinylation proteins", "Trafficking of AMPA receptors", "Ub-specific processing proteases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Stabilization of p53", "Regulation of RUNX3 expression and activity"], "17248": ["Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ub-specific processing proteases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Stabilization of p53"], "17250": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "ABC-family proteins mediated transport"], "17252": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "17254": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "17257": ["Regulation of MECP2 expression and activity"], "17258": ["CDO in myogenesis"], "17260": ["CDO in myogenesis"], "17261": ["CDO in myogenesis"], "17274": ["Regulation of PLK1 Activity at G2/M Transition", "Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "17283": ["Formation of the beta-catenin:TCF transactivating complex", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Deactivation of the beta-catenin transactivating complex", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RHO GTPases activate IQGAPs", "Post-translational protein phosphorylation"], "17289": ["Cell surface interactions at the vascular wall"], "17295": ["PIP3 activates AKT signaling", "Sema4D mediated inhibition of cell attachment and migration", "RAF/MAP kinase cascade", "MET Receptor Activation", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "MET activates PTPN11", "MET activates PTK2 signaling", "MET interacts with TNS proteins", "MET activates RAP1 and RAC1", "MET receptor recycling", "MET activates STAT3"], "17304": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "17308": ["N-glycan trimming and elongation in the cis-Golgi"], "17309": ["Reactions specific to the hybrid N-glycan synthesis pathway"], "17311": ["PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "17319": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "17329": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "17330": ["Synthesis of IPs in the ER lumen"], "17339": ["Passive transport by Aquaporins"], "17342": ["SUMOylation of transcription factors"], "17344": ["SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins"], "17346": ["Spry regulation of FGF signaling"], "17350": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "17356": ["Adherens junctions interactions"], "17364": ["TRP channels"], "17380": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "17381": ["Collagen degradation", "Degradation of the extracellular matrix"], "17384": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "17385": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "17386": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures"], "17387": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "17388": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "17389": ["Activation of Matrix Metalloproteinases"], "17390": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "EPH-ephrin mediated repulsion of cells"], "17391": ["Activation of Matrix Metalloproteinases"], "17392": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures", "EGFR Transactivation by Gastrin"], "17393": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures"], "17394": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "17395": ["Signaling by SCF-KIT", "Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures", "EPH-ephrin mediated repulsion of cells", "Neutrophil degranulation"], "17420": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Cyclin A/B1/B2 associated events during G2/M transition", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "17423": ["HS-GAG biosynthesis"], "17425": ["UCH proteinases"], "17434": ["Molybdenum cofactor biosynthesis"], "17436": ["Pyruvate metabolism"], "17444": ["Signaling by SCF-KIT", "Generation of second messenger molecules", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "CD28 co-stimulation"], "17448": ["Citric acid cycle (TCA cycle)"], "17449": ["Gluconeogenesis"], "17463": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "17470": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "17474": ["Neutrophil degranulation"], "17523": ["Neutrophil degranulation", "Events associated with phagocytolytic activity of PMN cells"], "17527": ["Peroxisomal protein import"], "17533": ["Cross-presentation of soluble exogenous antigens (endosomes)"], "17534": ["Cross-presentation of soluble exogenous antigens (endosomes)"], "17535": ["Cytosolic sensors of pathogen-associated DNA ", "DNA Damage/Telomere Stress Induced Senescence", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "G2/M DNA damage checkpoint"], "17540": ["cGMP effects"], "17684": ["Regulation of gene expression by Hypoxia-inducible Factor", "Activation of the TFAP2 (AP-2) family of transcription factors"], "17685": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "17686": ["Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "17688": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "17692": ["HATs acetylate histones"], "17698": ["Recycling pathway of L1"], "17705": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "17706": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "17716": ["Respiratory electron transport", "Complex I biogenesis"], "17717": ["Respiratory electron transport", "Complex I biogenesis"], "17718": ["Respiratory electron transport", "Complex I biogenesis"], "17719": ["Respiratory electron transport", "Complex I biogenesis"], "17721": ["Respiratory electron transport", "Complex I biogenesis"], "17722": ["Respiratory electron transport", "Complex I biogenesis"], "17749": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "17751": ["Metallothioneins bind metals"], "17762": ["Caspase-mediated cleavage of cytoskeletal proteins"], "17765": ["PRC2 methylates histones and DNA"], "17766": ["Phosphate bond hydrolysis by NUDT proteins"], "17768": ["Metabolism of folate and pterines"], "17769": ["Metabolism of folate and pterines"], "17772": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "17773": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "17777": ["Chylomicron assembly"], "17829": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "17833": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "17846": ["Neddylation"], "17847": ["TCF dependent signaling in response to WNT", "Ub-specific processing proteases"], "17850": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Propionyl-CoA catabolism"], "17855": ["Cholesterol biosynthesis"], "17858": ["ISG15 antiviral mechanism"], "17868": ["Striated Muscle Contraction"], "17874": ["PIP3 activates AKT signaling", "RIP-mediated NFkB activation via ZBP1", "p75NTR recruits signalling complexes", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "17877": ["CDO in myogenesis"], "17878": ["CDO in myogenesis"], "17880": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs"], "17882": ["Regulation of actin dynamics for phagocytic cup formation"], "17885": ["Striated Muscle Contraction"], "17886": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases activate PAKs"], "17888": ["Striated Muscle Contraction"], "17896": ["Striated Muscle Contraction"], "17897": ["Striated Muscle Contraction"], "17898": ["Smooth Muscle Contraction"], "17901": ["Striated Muscle Contraction"], "17904": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs"], "17906": ["Striated Muscle Contraction"], "17907": ["Smooth Muscle Contraction"], "17909": ["Regulation of actin dynamics for phagocytic cup formation"], "17913": ["Regulation of actin dynamics for phagocytic cup formation", "B-WICH complex positively regulates rRNA expression"], "17918": ["Regulation of actin dynamics for phagocytic cup formation"], "17919": ["Vasopressin regulates renal water homeostasis via Aquaporins"], "17920": ["Gap junction degradation", "Trafficking of AMPA receptors"], "17921": ["The canonical retinoid cycle in rods (twilight vision)"], "17925": ["Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "SLIT2:ROBO1 increases RHOA activity"], "17927": ["CDO in myogenesis"], "17928": ["CDO in myogenesis"], "17931": ["Regulation of PLK1 Activity at G2/M Transition", "RHO GTPases activate PKNs", "RHO GTPases activate PAKs"], "17957": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "17960": ["Acetylation"], "17961": ["Acetylation"], "17962": ["Acetylation"], "17967": ["NCAM signaling for neurite out-growth", "NCAM1 interactions", "Signal transduction by L1", "RAF/MAP kinase cascade"], "17969": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "17970": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "17972": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "17973": ["Downstream signal transduction", "Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "Nephrin family interactions", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "17974": ["Downstream signal transduction", "Nephrin family interactions", "Ephrin signaling", "VEGFA-VEGFR2 Pathway"], "17975": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "17977": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "HATs acetylate histones", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Estrogen-dependent gene expression"], "17978": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "HATs acetylate histones", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Estrogen-dependent gene expression"], "17979": ["MAPK6/MAPK4 signaling", "Estrogen-dependent gene expression"], "17991": ["Respiratory electron transport", "Complex I biogenesis"], "17993": ["Respiratory electron transport", "Complex I biogenesis"], "17995": ["Respiratory electron transport", "Complex I biogenesis"], "17996": ["Striated Muscle Contraction"], "17997": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "17999": ["ISG15 antiviral mechanism", "Downregulation of ERBB4 signaling", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "18000": ["Anchoring of the basal body to the plasma membrane"], "18002": ["TGF-beta receptor signaling activates SMADs", "UCH proteinases", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation", "Iron uptake and transport"], "18005": ["APC-Cdc20 mediated degradation of Nek2A", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "18010": ["Glycosphingolipid metabolism", "Sialic acid metabolism", "Neutrophil degranulation"], "18015": ["Regulation of RAS by GAPs"], "18016": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases activate PAKs"], "18018": ["Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "18019": ["Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) induces NFAT activation"], "18021": ["Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) induces NFAT activation"], "18022": ["Factors involved in megakaryocyte development and platelet production"], "18033": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "CLEC7A (Dectin-1) signaling", "CD209 (DC-SIGN) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neutrophil degranulation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "18034": ["RIP-mediated NFkB activation via ZBP1", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "SUMOylation of immune response proteins", "Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "TRAF6 mediated NF-kB activation"], "18035": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "SUMOylation of immune response proteins", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "18036": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "18037": ["Activation of NF-kappaB in B cells"], "18039": ["Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade"], "18041": ["Mitochondrial iron-sulfur cluster biogenesis", "Molybdenum cofactor biosynthesis"], "18049": ["NGF processing", "Frs2-mediated activation", "ARMS-mediated activation", "Retrograde neurotrophin signalling", "TRKA activation by NGF", "PI3K/AKT activation", "NFG and proNGF binds to p75NTR", "NADE modulates death signalling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Axonal growth stimulation"], "18053": ["Axonal growth inhibition (RHOA activation)", "Regulated proteolysis of p75NTR", "NFG and proNGF binds to p75NTR", "NADE modulates death signalling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Axonal growth stimulation"], "18073": ["Degradation of the extracellular matrix", "Laminin interactions"], "18074": ["Laminin interactions"], "18099": ["Ca2+ pathway"], "18100": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "18101": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "18102": ["Interconversion of nucleotide di- and triphosphates"], "18103": ["Interconversion of nucleotide di- and triphosphates", "Neutrophil degranulation"], "18104": ["Regulation of ornithine decarboxylase (ODC)"], "18105": ["Phase I - Functionalization of compounds"], "18106": ["Cell surface interactions at the vascular wall"], "18107": ["Inactivation, recovery and regulation of the phototransduction cascade", "Activation, myristolyation of BID and translocation to mitochondria"], "18108": ["Inactivation, recovery and regulation of the phototransduction cascade"], "18113": ["Methylation", "Nicotinamide salvaging"], "18115": ["Citric acid cycle (TCA cycle)"], "18120": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "18121": ["Signaling by BMP"], "18124": ["Nuclear Receptor transcription pathway"], "18125": ["ROS, RNS production in phagocytes", "Nitric oxide stimulates guanylate cyclase", "Ion homeostasis"], "18126": ["ROS, RNS production in phagocytes", "Nitric oxide stimulates guanylate cyclase", "Peroxisomal protein import"], "18127": ["ROS, RNS production in phagocytes", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "eNOS activation", "NOSTRIN mediated eNOS trafficking", "NOSIP mediated eNOS trafficking", "Nitric oxide stimulates guanylate cyclase", "VEGFR2 mediated vascular permeability"], "18128": ["Pre-NOTCH Processing in Golgi", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling"], "18129": ["Pre-NOTCH Processing in Golgi", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Notch-HLH transcription pathway"], "18130": ["RNA polymerase II transcribes snRNA genes"], "18131": ["Pre-NOTCH Processing in Golgi", "Notch-HLH transcription pathway", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3"], "18132": ["Pre-NOTCH Processing in Golgi", "Notch-HLH transcription pathway", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Negative regulation of NOTCH4 signaling"], "18141": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "18145": ["LDL clearance"], "18146": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "18155": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "18159": ["Physiological factors"], "18160": ["Physiological factors"], "18166": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "18167": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "18168": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "18171": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "18173": ["ROS, RNS production in phagocytes", "Metal ion SLC transporters", "Neutrophil degranulation", "Ion influx/efflux at host-pathogen interface"], "18174": ["Metal ion SLC transporters", "Iron uptake and transport"], "18176": ["Activation of RAS in B cells", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Neutrophil degranulation", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling"], "18183": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "18186": ["Neurophilin interactions with VEGF and VEGFR", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "Signal transduction by L1"], "18187": ["Neurophilin interactions with VEGF and VEGFR"], "18188": ["RAF/MAP kinase cascade", "RET signaling"], "18189": ["Neurexins and neuroligins"], "18190": ["Neurexins and neuroligins"], "18191": ["Neurexins and neuroligins"], "18193": ["PKMTs methylate histone lysines"], "18194": ["Cholesterol biosynthesis"], "18195": ["COPII-mediated vesicle transport", "Trafficking of GluR2-containing AMPA receptors", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "18201": ["TNFR1-mediated ceramide production"], "18205": ["NTF3 activates NTRK3 signaling", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PI3K"], "18207": ["Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "18208": ["Netrin-1 signaling", "DCC mediated attractive signaling"], "18211": ["Frs2-mediated activation", "ARMS-mediated activation", "Retrograde neurotrophin signalling", "TRKA activation by NGF", "PI3K/AKT activation"], "18212": ["Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through FRS2 and FRS3", "NTRK2 activates RAC1"], "18213": ["Receptor-type tyrosine-protein phosphatases", "NTF3 activates NTRK3 signaling", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PI3K"], "18214": ["Non-integrin membrane-ECM interactions"], "18216": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "18217": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "18218": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "18220": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "18221": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Mitotic Telophase/Cytokinesis"], "18222": ["Recycling pathway of L1", "Degradation of GLI1 by the proteasome", "Hedgehog 'on' state"], "18226": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "18227": ["Nuclear Receptor transcription pathway"], "18241": ["Amine ligand-binding receptors", "G alpha (q) signalling events"], "18242": ["Amino acid synthesis and interconversion (transamination)"], "18245": ["Regulation of ornithine decarboxylase (ODC)"], "18247": ["Regulation of ornithine decarboxylase (ODC)"], "18260": ["Apoptotic cleavage of cell adhesion  proteins"], "18263": ["Regulation of ornithine decarboxylase (ODC)", "Metabolism of polyamines"], "18286": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "18293": ["Glyoxylate metabolism and glycine degradation", "Lysine catabolism"], "18294": ["Cleavage of the damaged pyrimidine ", "Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "18295": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "18310": ["Olfactory Signaling Pathway"], "18312": ["Olfactory Signaling Pathway"], "18313": ["Olfactory Signaling Pathway"], "18314": ["Olfactory Signaling Pathway"], "18316": ["Olfactory Signaling Pathway"], "18317": ["Olfactory Signaling Pathway"], "18321": ["Olfactory Signaling Pathway"], "18322": ["Olfactory Signaling Pathway"], "18324": ["Olfactory Signaling Pathway"], "18328": ["Olfactory Signaling Pathway"], "18330": ["Olfactory Signaling Pathway"], "18331": ["Olfactory Signaling Pathway"], "18341": ["Olfactory Signaling Pathway"], "18346": ["Olfactory Signaling Pathway"], "18351": ["Olfactory Signaling Pathway"], "18352": ["Olfactory Signaling Pathway"], "18357": ["Olfactory Signaling Pathway"], "18365": ["Olfactory Signaling Pathway"], "18367": ["Olfactory Signaling Pathway"], "18369": ["Olfactory Signaling Pathway"], "18370": ["Olfactory Signaling Pathway"], "18372": ["Olfactory Signaling Pathway"], "18377": ["Axonal growth inhibition (RHOA activation)"], "18383": ["TNFs bind their physiological receptors"], "18386": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "18387": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "18389": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "18390": ["Opioid Signalling", "G-protein activation", "Peptide ligand-binding receptors", "G alpha (i) signalling events"], "18392": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "18393": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "18399": ["Organic anion transport"], "18400": ["Organic cation transport"], "18405": ["Platelet degranulation ", "Neutrophil degranulation"], "18406": ["Platelet degranulation ", "Neutrophil degranulation"], "18407": ["Platelet degranulation ", "Neutrophil degranulation"], "18408": ["Urea cycle"], "18412": ["NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Pink/Parkin Mediated Mitophagy", "Interleukin-1 signaling"], "18413": ["IL-6-type cytokine receptor ligand interactions"], "18414": ["IL-6-type cytokine receptor ligand interactions"], "18415": ["Regulation of HSF1-mediated heat shock response"], "18416": ["Mitochondrial protein import", "Urea cycle"], "18429": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "18430": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "18431": ["Melanin biosynthesis"], "18432": ["B-WICH complex positively regulates rRNA expression"], "18436": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis", "Neutrophil degranulation"], "18438": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "18439": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis", "The NLRP3 inflammasome"], "18440": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "18441": ["G alpha (q) signalling events", "P2Y receptors", "ADP signalling through P2Y purinoceptor 1"], "18442": ["G alpha (q) signalling events", "P2Y receptors", "Surfactant metabolism"], "18451": ["Collagen biosynthesis and modifying enzymes"], "18452": ["Collagen biosynthesis and modifying enzymes"], "18453": ["Collagen biosynthesis and modifying enzymes", "Detoxification of Reactive Oxygen Species", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Hedgehog ligand biogenesis", "Post-translational protein phosphorylation", "Chylomicron assembly", "Interleukin-12 signaling"], "18457": ["Golgi Associated Vesicle Biogenesis"], "18458": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "18459": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "18472": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "18475": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic"], "18476": ["COPI-independent Golgi-to-ER retrograde traffic"], "18477": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes"], "18478": ["Phenylalanine and tyrosine catabolism"], "18479": ["Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "FCERI mediated MAPK activation", "DSCAM interactions", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "Signal transduction by L1", "Smooth Muscle Contraction", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling", "G beta:gamma signalling through CDC42"], "18481": ["Generation of second messenger molecules", "CD28 dependent Vav1 pathway", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling"], "18488": ["Post-translational modification: synthesis of GPI-anchored proteins"], "18489": ["Antimicrobial peptides"], "18491": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "18505": ["HATs acetylate histones"], "18507": ["RUNX1 regulates transcription of genes involved in BCR signaling"], "18519": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Notch-HLH transcription pathway", "B-WICH complex positively regulates rRNA expression", "Metalloprotease DUBs", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX3 regulates NOTCH signaling", "Estrogen-dependent gene expression", "Regulation of FOXO transcriptional activity by acetylation"], "18534": ["Gluconeogenesis"], "18536": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "18537": ["Protein repair"], "18538": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "SUMOylation of DNA replication proteins", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand", "E3 ubiquitin ligases ubiquitinate target proteins"], "18541": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "18542": ["Collagen biosynthesis and modifying enzymes"], "18545": ["G alpha (i) signalling events"], "18548": ["Peptide hormone biosynthesis"], "18550": ["Elastic fibre formation", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "NGF processing", "Formation of the cornified envelope", "Assembly of active LPL and LIPC lipase complexes"], "18552": ["NGF processing", "Assembly of active LPL and LIPC lipase complexes"], "18553": ["NGF processing", "Formation of the cornified envelope", "Assembly of active LPL and LIPC lipase complexes"], "18559": ["Synthesis of PC", "Mitochondrial Fatty Acid Beta-Oxidation"], "18563": ["Biotin transport and metabolism", "Gluconeogenesis"], "18566": ["PD-1 signaling"], "18572": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "18573": ["Cam-PDE 1 activation", "cGMP effects", "G alpha (s) signalling events"], "18574": ["Cam-PDE 1 activation", "cGMP effects", "G alpha (s) signalling events"], "18575": ["Cam-PDE 1 activation"], "18576": ["PDE3B signalling", "cGMP effects", "G alpha (s) signalling events"], "18577": ["DARPP-32 events", "G alpha (s) signalling events"], "18578": ["DARPP-32 events", "G alpha (s) signalling events"], "18582": ["ARL13B-mediated ciliary trafficking of INPP5E"], "18583": ["G alpha (s) signalling events"], "18584": ["G alpha (s) signalling events"], "18585": ["cGMP effects"], "18587": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway"], "18588": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway"], "18590": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Non-integrin membrane-ECM interactions", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "18591": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Non-integrin membrane-ECM interactions", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "18595": ["PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "18596": ["PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "18597": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "18598": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "18599": ["Chromatin modifying enzymes"], "18600": ["Chromatin modifying enzymes", "Neutrophil degranulation"], "18601": ["Chromatin modifying enzymes"], "18602": ["Chromatin modifying enzymes"], "18604": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "18605": ["Vitamin B2 (riboflavin) metabolism"], "18607": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Activation of AKT2", "Downstream TCR signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated NF-kB activation", "Integrin alphaIIb beta3 signaling", "CD28 dependent PI3K/Akt signaling", "G beta:gamma signalling through PI3Kgamma", "VEGFR2 mediated vascular permeability", "VEGFR2 mediated cell proliferation", "CLEC7A (Dectin-1) signaling", "RHO GTPases activate PKNs"], "18610": ["Opioid Signalling", "G-protein activation", "Peptide ligand-binding receptors", "G alpha (i) signalling events"], "18611": ["RAF-independent MAPK1/3 activation", "RAF/MAP kinase cascade"], "18612": ["MAPK6/MAPK4 signaling"], "18613": ["Platelet degranulation ", "Cell surface interactions at the vascular wall", "PECAM1 interactions", "Integrin cell surface interactions", "Platelet sensitization by LDL", "Neutrophil degranulation"], "18618": ["Synthesis of PC"], "18619": ["Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (i) signalling events", "Post-translational protein phosphorylation"], "18634": ["Peroxisomal protein import"], "18636": ["Alternative complement activation", "Activation of C3 and C5", "O-glycosylation of TSR domain-containing proteins", "Neutrophil degranulation", "Regulation of Complement cascade"], "18639": ["Glycolysis"], "18640": ["Glycolysis"], "18641": ["Neutrophil degranulation", "Glycolysis"], "18642": ["Glycolysis"], "18643": ["Signaling by ROBO receptors", "PCP/CE pathway", "RHO GTPases Activate Formins"], "18645": ["Signaling by ROBO receptors", "RHO GTPases Activate Formins"], "18648": ["Neutrophil degranulation", "Gluconeogenesis"], "18654": ["VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "18655": ["Gluconeogenesis"], "18663": ["Gluconeogenesis"], "18667": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Estrogen-dependent gene expression"], "18669": ["ABC-family proteins mediated transport"], "18670": ["ABC-family proteins mediated transport"], "18671": ["ABC-family proteins mediated transport"], "18673": ["RAF activation", "Processing of SMDT1"], "18676": ["HDMs demethylate histones"], "18679": ["Glycogen breakdown (glycogenolysis)"], "18682": ["Glycogen breakdown (glycogenolysis)"], "18693": ["Trafficking of GluR2-containing AMPA receptors"], "18700": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "18701": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "18703": ["Neutrophil degranulation"], "18704": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "18706": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PI3K events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "GAB1 signalosome", "Downstream signal transduction", "PI3K events in ERBB2 signaling", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL"], "18707": ["PIP3 activates AKT signaling", "Synthesis of PIPs at the plasma membrane", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "18708": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PI3K events in ERBB4 signaling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "GAB1 signalosome", "Downstream signal transduction", "PI3K events in ERBB2 signaling", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "GP1b-IX-V activation signalling", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "18709": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "Downstream signal transduction", "Rho GTPase cycle", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL"], "18710": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL"], "18711": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "18716": ["Miscellaneous transport and binding events"], "18717": ["Synthesis of PIPs at the plasma membrane", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Clathrin-mediated endocytosis"], "18718": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "18719": ["Synthesis of PIPs at the plasma membrane", "WNT mediated activation of DVL", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "18720": ["Synthesis of PIPs at the plasma membrane", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "18739": ["Synthesis of PI"], "18744": ["Antigen processing: Ubiquitination & Proteasome degradation"], "18746": ["Neutrophil degranulation", "Glycolysis"], "18747": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "AURKA Activation by TPX2", "HDL assembly", "Factors involved in megakaryocyte development and platelet production"], "18749": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "HDL assembly", "Factors involved in megakaryocyte development and platelet production"], "18750": ["Calmodulin induced events", "Disinhibition of SNARE formation", "SHC1 events in ERBB2 signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "EGFR Transactivation by Gastrin", "Syndecan interactions", "Acetylcholine regulates insulin secretion", "Depolymerisation of the Nuclear Lamina", "HuR (ELAVL1) binds and stabilizes mRNA", "WNT5A-dependent internalization of FZD4", "VEGFR2 mediated cell proliferation", "Response to elevated platelet cytosolic Ca2+", "RET signaling", "ROBO receptors bind AKAP5"], "18751": ["Disinhibition of SNARE formation", "Activation of NF-kappaB in B cells", "Depolymerisation of the Nuclear Lamina", "WNT5A-dependent internalization of FZD4", "VEGFR2 mediated cell proliferation", "Response to elevated platelet cytosolic Ca2+"], "18752": ["Calmodulin induced events", "Disinhibition of SNARE formation", "WNT5A-dependent internalization of FZD4", "Response to elevated platelet cytosolic Ca2+"], "18753": ["Apoptotic cleavage of cellular proteins", "Calmodulin induced events", "Effects of PIP2 hydrolysis", "SHC1 events in ERBB2 signaling", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "HuR (ELAVL1) binds and stabilizes mRNA", "VEGFR2 mediated cell proliferation", "CLEC7A (Dectin-1) signaling", "Neutrophil degranulation", "Interferon gamma signaling"], "18754": ["Effects of PIP2 hydrolysis", "SHC1 events in ERBB2 signaling", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis"], "18755": ["Effects of PIP2 hydrolysis"], "18759": ["Pre-NOTCH Transcription and Translation", "p75NTR recruits signalling complexes", "Tight junction interactions"], "18760": ["Sphingolipid de novo biosynthesis"], "18761": ["Apoptotic cleavage of cellular proteins", "Effects of PIP2 hydrolysis", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "Netrin-1 signaling"], "18762": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "VEGFR2 mediated cell proliferation"], "18763": ["VxPx cargo-targeting to cilium"], "18764": ["VxPx cargo-targeting to cilium"], "18770": ["Glycolysis"], "18772": ["Apoptotic cleavage of cell adhesion  proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "18777": ["eNOS activation"], "18778": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "18779": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "18782": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "18783": ["phospho-PLA2 pathway", "Acyl chain remodelling of PC", "Acyl chain remodeling of CL", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC", "Synthesis of PA", "Arachidonic acid metabolism", "ADP signalling through P2Y purinoceptor 1", "Platelet sensitization by LDL", "COPI-independent Golgi-to-ER retrograde traffic"], "18784": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "18787": ["Platelet degranulation ", "ECM proteoglycans", "Dissolution of Fibrin Clot"], "18788": ["Dissolution of Fibrin Clot"], "18789": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "18791": ["Signaling by PDGF", "Dissolution of Fibrin Clot"], "18792": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "18793": ["Attachment of GPI anchor to uPAR", "Neutrophil degranulation", "Dissolution of Fibrin Clot"], "18795": ["PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "18796": ["PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "18797": ["PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "18798": ["PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "G alpha (q) signalling events"], "18799": ["Synthesis of IP3 and IP4 in the cytosol"], "18802": ["Synthesis of IP3 and IP4 in the cytosol"], "18803": ["ISG15 antiviral mechanism", "Synthesis of IP3 and IP4 in the cytosol", "Downstream signal transduction", "Generation of second messenger molecules", "Role of phospholipids in phagocytosis", "PECAM1 interactions", "EGFR interacts with phospholipase C-gamma", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "VEGFR2 mediated cell proliferation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "RET signaling", "Activated NTRK2 signals through PLCG1", "Activated NTRK3 signals through PLCG1"], "18805": ["Synthesis of PA", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "18806": ["Synthesis of PA", "Role of phospholipids in phagocytosis"], "18807": ["Role of phospholipids in phagocytosis"], "18810": ["Assembly of collagen fibrils and other multimeric structures", "Caspase-mediated cleavage of cytoskeletal proteins", "Type I hemidesmosome assembly"], "18813": ["Neutrophil degranulation"], "18815": ["Platelet degranulation ", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Signaling by PDGF", "Dissolution of Fibrin Clot"], "18816": ["Platelet degranulation ", "Dissolution of Fibrin Clot"], "18817": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Polo-like kinase mediated events", "Golgi Cisternae Pericentriolar Stack Reorganization", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Condensation of Prophase Chromosomes", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Mitotic Telophase/Cytokinesis", "Cyclin A/B1/B2 associated events during G2/M transition", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2"], "18821": ["Ion homeostasis", "Ion transport by P-type ATPases"], "18822": ["Collagen biosynthesis and modifying enzymes"], "18829": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "18830": ["HDL remodeling"], "18843": ["Antimicrobial peptides"], "18844": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "Other semaphorin interactions"], "18845": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "18846": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "18854": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Regulation of TP53 Activity through Acetylation", "Regulation of RUNX1 Expression and Activity", "Regulation of PTEN localization"], "18861": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "18946": ["Digestion of dietary lipid"], "18947": ["Digestion of dietary lipid"], "18948": ["Catecholamine biosynthesis"], "18950": ["Neutrophil degranulation", "Purine catabolism"], "18952": ["Release of apoptotic factors from the mitochondria", "SMAC, XIAP-regulated apoptotic response"], "18968": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "18969": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "18970": ["POLB-Dependent Long Patch Base Excision Repair", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "PCNA-Dependent Long Patch Base Excision Repair", "Ub-specific processing proteases", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "18971": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "18972": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "18973": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "18974": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "18976": ["Opioid Signalling", "Androgen biosynthesis", "Glucocorticoid biosynthesis", "G-protein activation", "Peptide hormone biosynthesis", "Endogenous sterols", "Peptide ligand-binding receptors", "G alpha (s) signalling events", "G alpha (i) signalling events"], "18979": ["Synthesis of 5-eicosatetraenoic acids"], "18983": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "18986": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "Estrogen-dependent gene expression"], "18987": ["RNA polymerase II transcribes snRNA genes"], "18996": ["Regulation of TP53 Activity through Association with Co-factors"], "18997": ["Regulation of TP53 Activity through Association with Co-factors"], "19012": ["Sphingolipid de novo biosynthesis"], "19013": ["Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "SUMOylation of intracellular receptors"], "19014": ["Generic Transcription Pathway", "Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Estrogen-dependent gene expression"], "19015": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Regulation of pyruvate dehydrogenase (PDH) complex", "Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "19016": ["Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway"], "19024": ["Receptor-type tyrosine-protein phosphatases"], "19025": ["Glycosphingolipid metabolism", "MHC class II antigen presentation", "Sialic acid metabolism", "Neutrophil degranulation"], "19035": ["Collagen biosynthesis and modifying enzymes"], "19039": ["Platelet degranulation "], "19041": ["Formation of the cornified envelope", "Butyrophilin (BTN) family interactions"], "19042": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Energy dependent regulation of mTOR by LKB1-AMPK"], "19043": ["ISG15 antiviral mechanism"], "19044": ["Heme biosynthesis"], "19045": ["DARPP-32 events"], "19046": ["Regulation of PLK1 Activity at G2/M Transition", "RHO GTPases activate PKNs", "RHO GTPases activate PAKs"], "19047": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "19049": ["DARPP-32 events"], "19052": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "19053": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition"], "19055": ["Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "19056": ["Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "19057": ["Activation of BAD and translocation to mitochondria "], "19058": ["Activation of BAD and translocation to mitochondria ", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "19060": ["Negative regulation of MAPK pathway", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "ESR-mediated signaling"], "19062": ["Synthesis of PIPs at the plasma membrane"], "19063": ["Fatty acyl-CoA biosynthesis"], "19064": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "19065": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "19069": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "19073": ["Platelet degranulation "], "19074": ["Neutrophil degranulation"], "19075": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "19076": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "19079": ["Macroautophagy", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "19082": ["Macroautophagy", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "19084": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Factors involved in megakaryocyte development and platelet production"], "19085": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Factors involved in megakaryocyte development and platelet production"], "19087": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Factors involved in megakaryocyte development and platelet production"], "19088": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2", "Factors involved in megakaryocyte development and platelet production"], "19089": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "19090": ["Nonhomologous End-Joining (NHEJ)"], "19091": ["Rap1 signalling", "cGMP effects"], "19092": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "cGMP effects"], "19094": ["NOD1/2 Signaling Pathway", "p38MAPK events", "ERK/MAPK targets", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "DSCAM interactions", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Activation of the AP-1 family of transcription factors", "RHO GTPases Activate NADPH Oxidases", "Regulation of TP53 Activity through Phosphorylation"], "19106": ["ISG15 antiviral mechanism"], "19116": ["Prolactin receptor signaling", "Growth hormone receptor signaling"], "19123": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "19124": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "19125": ["Proline catabolism"], "19128": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall"], "19139": ["5-Phosphoribose 1-diphosphate biosynthesis"], "19141": ["Trafficking and processing of endosomal TLR", "Vitamin D (calciferol) metabolism"], "19143": ["Formation of the cornified envelope"], "19152": ["Common Pathway of Fibrin Clot Formation", "Neutrophil degranulation", "Antimicrobial peptides"], "19155": ["Antigen processing: Ubiquitination & Proteasome degradation"], "19156": ["Platelet degranulation ", "Glycosphingolipid metabolism", "Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation"], "19157": ["Intra-Golgi traffic"], "19158": ["Intra-Golgi traffic"], "19159": ["Intra-Golgi traffic"], "19164": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Neutrophil degranulation", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "19165": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "19166": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19167": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19170": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19171": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19172": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19173": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19175": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19177": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19179": ["Autodegradation of Cdh1 by Cdh1:APC/C", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19181": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19182": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19184": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19185": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19186": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19188": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19192": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "19193": ["Lysine catabolism", "Peroxisomal protein import"], "19194": ["Antimicrobial peptides"], "19197": ["RAF/MAP kinase cascade", "RET signaling"], "19200": ["The NLRP3 inflammasome"], "19204": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events", "Neutrophil degranulation"], "19205": ["mRNA Splicing - Major Pathway"], "19206": ["Hedgehog 'off' state", "Ligand-receptor interactions", "Hedgehog 'on' state", "Activation of SMO"], "19210": ["Synthesis of PS"], "19211": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Negative regulation of the PI3K/AKT network", "Downstream TCR signaling", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Regulation of PTEN localization", "Regulation of PTEN stability and activity"], "192113": ["Ion transport by P-type ATPases"], "192119": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "19214": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "19215": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "192156": ["Cholesterol biosynthesis", "Synthesis of Dolichyl-phosphate"], "192159": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "19216": ["Prostanoid ligand receptors", "G alpha (q) signalling events"], "192160": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "192166": ["Choline catabolism"], "192167": ["Neurexins and neuroligins"], "19217": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "192170": ["Cleavage of Growing Transcript in the Termination Region ", "ISG15 antiviral mechanism", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Deadenylation of mRNA", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "192176": ["Platelet degranulation ", "GP1b-IX-V activation signalling", "Cell-extracellular matrix interactions", "RHO GTPases activate PAKs"], "19218": ["Prostanoid ligand receptors", "G alpha (i) signalling events"], "192185": ["Nicotinate metabolism"], "192187": ["Scavenging by Class H Receptors"], "192188": ["Hyaluronan uptake and degradation", "Scavenging by Class H Receptors"], "19219": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "192194": ["Butyrophilin (BTN) family interactions"], "192195": ["PKMTs methylate histone lysines"], "192199": ["Regulation of FZD by ubiquitination"], "19220": ["Prostanoid ligand receptors", "G alpha (q) signalling events"], "19222": ["Prostanoid ligand receptors", "Prostacyclin signalling through prostacyclin receptor", "G alpha (s) signalling events"], "19223": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Nicotinamide salvaging", "Eicosanoids", "Sterols are 12-hydroxylated by CYP8B1", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "192232": ["RAB GEFs exchange GTP for GDP on RABs"], "192236": ["RAB GEFs exchange GTP for GDP on RABs"], "19224": ["COX reactions", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "19225": ["Nicotinamide salvaging", "Synthesis of 15-eicosatetraenoic acid derivatives", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Biosynthesis of EPA-derived SPMs", "Biosynthesis of DPAn-3 SPMs", "Biosynthesis of electrophilic \u03c9-3 PUFA oxo-derivatives"], "19226": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "19227": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "19228": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "192285": ["HDACs deacetylate histones", "Factors involved in megakaryocyte development and platelet production"], "192289": ["Carnitine synthesis"], "19229": ["Signal regulatory protein family interactions", "VEGFA-VEGFR2 Pathway", "Interleukin-2 signaling"], "192292": ["Nuclear Receptor transcription pathway"], "19241": ["Platelet degranulation "], "19244": ["RAB geranylgeranylation"], "19246": ["Integrin alphaIIb beta3 signaling", "Negative regulation of MET activity", "PTK6 Down-Regulation", "Growth hormone receptor signaling"], "19247": ["Interleukin-6 signaling", "PI3K Cascade", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "GAB1 signalosome", "Downstream signal transduction", "PECAM1 interactions", "Tie2 Signaling", "Costimulation by the CD28 family", "CTLA4 inhibitory signaling", "PD-1 signaling", "Platelet sensitization by LDL", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin-20 family signaling", "MET activates PTPN11", "Regulation of RUNX1 Expression and Activity", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "19248": ["SHC1 events in ERBB2 signaling", "Downregulation of ERBB2 signaling"], "19249": ["Synthesis of PIPs at the plasma membrane"], "19252": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "19253": ["Downregulation of ERBB2 signaling"], "19255": ["Negative regulation of MET activity", "Regulation of IFNG signaling"], "19258": ["Toll Like Receptor 4 (TLR4) Cascade"], "19260": ["Phosphorylation of CD3 and TCR zeta chains"], "19261": ["Cell surface interactions at the vascular wall", "DAP12 interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "19262": ["NCAM signaling for neurite out-growth", "RAF/MAP kinase cascade"], "19263": ["Neutrophil degranulation"], "19264": ["Phosphorylation of CD3 and TCR zeta chains", "Other semaphorin interactions", "Neutrophil degranulation"], "192651": ["Generic Transcription Pathway"], "192654": ["Hydrolysis of LPC"], "192656": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "p75NTR recruits signalling complexes", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "192657": ["RNA polymerase II transcribes snRNA genes"], "19266": ["Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules"], "192662": ["Axonal growth inhibition (RHOA activation)", "Rho GTPase cycle", "Axonal growth stimulation"], "192663": ["ABC transporters in lipid homeostasis"], "19268": ["Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules"], "19271": ["Phosphorylation of CD3 and TCR zeta chains", "Neutrophil degranulation", "Negative regulation of MET activity"], "19272": ["EGFR downregulation"], "19273": ["Signaling by SCF-KIT"], "19276": ["Neutrophil degranulation"], "192775": ["Voltage gated Potassium channels"], "19280": ["Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules"], "19283": ["Other interleukin signaling"], "19285": ["RNA Polymerase I Transcription Termination"], "19286": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "19288": ["Neutrophil degranulation"], "192897": ["Assembly of collagen fibrils and other multimeric structures", "Laminin interactions", "Syndecan interactions", "Type I hemidesmosome assembly"], "19294": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "19298": ["ABC transporters in lipid homeostasis"], "19299": ["ABC transporters in lipid homeostasis"], "19300": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "19302": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "19303": ["GAB1 signalosome", "VEGFA-VEGFR2 Pathway", "Smooth Muscle Contraction", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "193034": ["TRP channels"], "19305": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "193053": ["Olfactory Signaling Pathway"], "19309": ["Glycogen breakdown (glycogenolysis)"], "193116": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "19324": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "19325": ["Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "19326": ["TBC/RABGAPs", "RAB geranylgeranylation"], "19328": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "19329": ["RAB geranylgeranylation"], "19330": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "19331": ["RAB geranylgeranylation"], "19332": ["RAB geranylgeranylation"], "19334": ["RAB geranylgeranylation"], "19335": ["RAB geranylgeranylation"], "19336": ["Neutrophil degranulation", "RAB geranylgeranylation"], "19337": ["TBC/RABGAPs", "RAB geranylgeranylation"], "19338": ["Intra-Golgi traffic", "TBC/RABGAPs", "RAB geranylgeranylation"], "19339": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs", "GABA synthesis, release, reuptake and degradation"], "19340": ["Neutrophil degranulation", "RAB geranylgeranylation"], "19341": ["Synthesis of PIPs at the plasma membrane", "TBC/RABGAPs", "RAB geranylgeranylation", "MET receptor recycling"], "19342": ["Neutrophil degranulation", "RAB geranylgeranylation", "MET receptor recycling"], "19344": ["Neutrophil degranulation", "Clathrin-mediated endocytosis", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "19345": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Clathrin-mediated endocytosis", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "19346": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic", "Retrograde transport at the Trans-Golgi-Network", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "19347": ["RAB GEFs exchange GTP for GDP on RABs"], "19348": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Telophase/Cytokinesis", "Kinesins"], "19349": ["MHC class II antigen presentation", "Neutrophil degranulation", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "19352": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation"], "19353": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "DSCAM interactions", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "Sema3A PAK dependent Axon repulsion", "PCP/CE pathway", "Sema4D mediated inhibition of cell attachment and migration", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "VEGFR2 mediated vascular permeability", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate KTN1", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate NADPH Oxidases", "MAPK6/MAPK4 signaling", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAP1 and RAC1", "NTRK2 activates RAC1", "Factors involved in megakaryocyte development and platelet production"], "19354": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Rho GTPase cycle", "PCP/CE pathway", "RHO GTPases Activate NADPH Oxidases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "19355": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "19356": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "19357": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins"], "19358": ["Josephin domain DUBs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "19359": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Josephin domain DUBs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "19360": ["DNA Damage/Telomere Stress Induced Senescence", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "G2/M DNA damage checkpoint"], "19361": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "19362": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "19363": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Factors involved in megakaryocyte development and platelet production"], "19364": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "19365": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)"], "19367": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "193740": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Neutrophil degranulation"], "19376": ["RAB geranylgeranylation"], "19378": ["RA biosynthesis pathway"], "193796": ["HDMs demethylate histones", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Estrogen-dependent gene expression"], "193813": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "193838": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "19386": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "19387": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "19395": ["Integrin alphaIIb beta3 signaling", "Rap1 signalling"], "19401": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Signaling by Retinoic Acid"], "19411": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "19414": ["Regulation of RAS by GAPs"], "19415": ["Regulation of RAS by GAPs"], "19417": ["RAF/MAP kinase cascade"], "19419": ["Activation of RAS in B cells", "Integrin alphaIIb beta3 signaling", "Rap1 signalling", "RAF/MAP kinase cascade"], "194231": ["MAP2K and MAPK activation"], "194237": ["Amino acid synthesis and interconversion (transamination)"], "194309": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "194352": ["TRP channels"], "194590": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "194908": ["Synthesis of PA"], "195046": ["The NLRP1 inflammasome"], "195434": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "195522": ["Generic Transcription Pathway"], "195646": ["HS-GAG biosynthesis"], "19645": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Condensation of Prophase Chromosomes", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry"], "19647": ["Antigen processing: Ubiquitination & Proteasome degradation"], "19649": ["Regulation of commissural axon pathfinding by SLIT and ROBO", "ROBO receptors bind AKAP5"], "19650": ["G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Cyclin D associated events in G1"], "19651": ["G0 and Early G1", "Cyclin D associated events in G1"], "19659": ["The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism and transport"], "19660": ["Retinoid metabolism and transport"], "19661": ["The canonical retinoid cycle in rods (twilight vision)"], "19662": ["The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism and transport"], "19664": ["NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling"], "19671": ["Ub-specific processing proteases"], "19672": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "19674": ["Inactivation, recovery and regulation of the phototransduction cascade"], "19679": ["Synthesis of PI"], "19682": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "19683": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "19684": ["Recycling pathway of L1"], "19687": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "19694": ["Antimicrobial peptides"], "19695": ["Antimicrobial peptides"], "19696": ["Activation of NF-kappaB in B cells"], "19697": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "SUMOylation of immune response proteins", "CLEC7A (Dectin-1) signaling", "CD209 (DC-SIGN) signaling", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "19698": ["Dectin-1 mediated noncanonical NF-kB signaling", "CD209 (DC-SIGN) signaling", "NIK-->noncanonical NF-kB signaling"], "19699": ["Reelin signalling pathway"], "19701": ["Metabolism of Angiotensinogen to Angiotensins"], "19703": ["Synthesis of UDP-N-acetyl-glucosamine"], "19704": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "19707": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "19712": ["HDACs deacetylate histones"], "19713": ["RAF/MAP kinase cascade", "RET signaling"], "19714": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI"], "19718": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "19720": ["SUMOylation of ubiquitinylation proteins", "Regulation of PTEN stability and activity"], "19729": ["Cellular hexose transport"], "19730": ["p38MAPK events"], "19734": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "19735": ["G alpha (q) signalling events"], "19736": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "19737": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "19739": ["Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "19743": ["Erythrocytes take up carbon dioxide and release oxygen", "Rhesus glycoproteins mediate ammonium transport."], "19744": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "19763": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "19765": ["Rho GTPase cycle"], "19766": ["Caspase activation via Death Receptors in the presence of ligand", "TRIF-mediated programmed cell death", "TRP channels", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Dimerization of procaspase-8", "TNF signaling", "IKK complex recruitment mediated by RIP1"], "19771": ["The retinoid cycle in cones (daylight vision)", "The canonical retinoid cycle in rods (twilight vision)"], "19773": ["G alpha (s) signalling events", "Relaxin receptors"], "19820": ["Antigen processing: Ubiquitination & Proteasome degradation"], "19821": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "19822": ["Processing of DNA double-strand break ends", "Antigen processing: Ubiquitination & Proteasome degradation"], "19826": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "19876": ["Signaling by ROBO receptors", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Role of ABL in ROBO-SLIT signaling", "SLIT2:ROBO1 increases RHOA activity", "Regulation of expression of SLITs and ROBOs"], "19877": ["Apoptotic cleavage of cellular proteins", "EPHB-mediated forward signaling", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate ROCKs", "Neutrophil degranulation"], "19878": ["EPHB-mediated forward signaling", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate ROCKs"], "19879": ["Organic anion transport"], "19883": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "19885": ["Nuclear Receptor transcription pathway"], "19889": ["Trafficking of myristoylated proteins to the cilium"], "19891": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate"], "19892": ["The canonical retinoid cycle in rods (twilight vision)"], "19895": ["Pentose phosphate pathway"], "19935": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "20016": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "20017": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "20018": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "20019": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "20020": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "20021": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "20022": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "20042": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "20044": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "20054": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "20055": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "20084": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "20091": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "20102": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "20103": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "20111": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "20112": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "20115": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "20129": ["Formation of the cornified envelope"], "20130": ["Sema4D mediated inhibition of cell attachment and migration"], "20132": ["G alpha (i) signalling events", "Opsins"], "20133": ["Interconversion of nucleotide di- and triphosphates"], "20135": ["Interconversion of nucleotide di- and triphosphates"], "20148": ["The retinoid cycle in cones (daylight vision)", "RA biosynthesis pathway"], "20163": ["Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "20166": ["RHO GTPases Activate Rhotekin and Rhophilins"], "20168": ["Synaptic adhesion-like molecules"], "20181": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Import of palmitoyl-CoA into the mitochondrial matrix", "Regulation of pyruvate dehydrogenase (PDH) complex", "Endogenous sterols", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "SUMOylation of intracellular receptors", "Signaling by Retinoic Acid"], "20182": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "20183": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "20184": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "20185": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "HDACs deacetylate histones", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "20186": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "20187": ["TCF dependent signaling in response to WNT"], "20190": ["Stimuli-sensing channels", "Ion homeostasis"], "20191": ["Stimuli-sensing channels", "Ion homeostasis"], "20192": ["Stimuli-sensing channels", "Ion homeostasis"], "20193": ["Regulation of TLR by endogenous ligand"], "20194": ["Dissolution of Fibrin Clot"], "20195": ["Neutrophil degranulation"], "20201": ["RHO GTPases Activate NADPH Oxidases", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "20202": ["RHO GTPases Activate NADPH Oxidases", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "20203": ["TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "20215": ["Inactivation, recovery and regulation of the phototransduction cascade"], "20218": ["PTK6 Regulates Proteins Involved in RNA Processing"], "20220": ["HDACs deacetylate histones"], "20222": ["mRNA Splicing - Major Pathway"], "20227": ["mRNA Splicing - Major Pathway"], "20229": ["Interconversion of polyamines"], "20230": ["Apoptotic cleavage of cellular proteins", "SUMOylation of chromatin organization proteins"], "20248": ["Neutrophil degranulation"], "20249": ["Fatty acyl-CoA biosynthesis"], "20250": ["Fatty acyl-CoA biosynthesis"], "20254": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "20255": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "20264": ["Phase 0 - rapid depolarisation"], "20265": ["Phase 0 - rapid depolarisation"], "20266": ["Phase 0 - rapid depolarisation"], "20269": ["Phase 0 - rapid depolarisation"], "20271": ["Phase 0 - rapid depolarisation"], "20272": ["Phase 0 - rapid depolarisation"], "20273": ["Phase 0 - rapid depolarisation"], "20274": ["Phase 0 - rapid depolarisation"], "20276": ["Stimuli-sensing channels"], "20277": ["Stimuli-sensing channels"], "20278": ["Stimuli-sensing channels"], "20280": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "alpha-linolenic acid (ALA) metabolism", "Peroxisomal protein import"], "20287": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "20288": ["Scavenging by Class A Receptors"], "20290": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "20297": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "20300": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "20301": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "20303": ["G alpha (i) signalling events"], "20304": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "20305": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "20308": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "20310": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "20311": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "20312": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "20315": ["Signaling by ROBO receptors", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "20322": ["Fructose biosynthesis", "Formation of xylulose-5-phosphate"], "20333": ["ER-Phagosome pathway", "COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-dependent Golgi-to-ER retrograde traffic"], "20334": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "20335": ["XBP1(S) activates chaperone genes"], "20336": ["Insulin processing", "VxPx cargo-targeting to cilium"], "20338": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "ER Quality Control Compartment (ERQC)"], "20339": ["Cell surface interactions at the vascular wall"], "20340": ["Cell surface interactions at the vascular wall"], "20343": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "20344": ["Platelet degranulation ", "Cell surface interactions at the vascular wall"], "20345": ["Cell surface interactions at the vascular wall"], "20346": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "20349": ["Other semaphorin interactions"], "20351": ["Other semaphorin interactions"], "20354": ["Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse", "Other semaphorin interactions"], "20356": ["Other semaphorin interactions", "O-glycosylation of TSR domain-containing proteins"], "20357": ["O-glycosylation of TSR domain-containing proteins"], "20361": ["Other semaphorin interactions"], "20363": ["Platelet degranulation "], "20371": ["RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "20382": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "20383": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "20384": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "20387": ["Toll Like Receptor 4 (TLR4) Cascade", "Signal regulatory protein family interactions", "Surfactant metabolism", "Regulation of TLR by endogenous ligand"], "20388": ["Surfactant metabolism"], "20389": ["Surfactant metabolism"], "20390": ["Toll Like Receptor 4 (TLR4) Cascade", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Signal regulatory protein family interactions", "Surfactant metabolism", "Regulation of TLR by endogenous ligand"], "20393": ["Stimuli-sensing channels", "Regulation of TP53 Degradation"], "20397": ["Sphingolipid de novo biosynthesis"], "20399": ["Prolactin receptor signaling", "Growth hormone receptor signaling", "Factors involved in megakaryocyte development and platelet production"], "20400": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "20403": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "20404": ["Retrograde neurotrophin signalling", "EGFR downregulation", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "20405": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "20408": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "20409": ["Neutrophil degranulation"], "20410": ["Smooth Muscle Contraction"], "20411": ["Smooth Muscle Contraction"], "20416": ["SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signalling to RAS", "SHC1 events in EGFR signaling", "Tie2 Signaling", "DAP12 signaling", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "Integrin alphaIIb beta3 signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "SHC-mediated cascade:FGFR1", "SHC-mediated cascade:FGFR2", "SHC-mediated cascade:FGFR3", "SHC-mediated cascade:FGFR4", "RAF/MAP kinase cascade", "Signal attenuation", "Insulin receptor signalling cascade", "MET activates RAS signaling", "RET signaling", "Interleukin-15 signaling", "Interleukin-2 signaling", "Erythropoietin activates RAS", "Interleukin receptor SHC signaling"], "20418": ["Signalling to RAS", "RAF/MAP kinase cascade", "RET signaling"], "20423": ["Hedgehog ligand biogenesis", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Activation of SMO"], "20425": ["Carnitine synthesis"], "20430": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation"], "20437": ["Netrin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "20438": ["Netrin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "20439": ["Netrin-1 signaling", "Ub-specific processing proteases", "Antigen processing: Ubiquitination & Proteasome degradation"], "20440": ["Sialic acid metabolism", "N-Glycan antennae elongation", "Termination of O-glycan biosynthesis"], "20441": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "20442": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "20443": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "N-Glycan antennae elongation", "Termination of O-glycan biosynthesis"], "20444": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "20445": ["Sialic acid metabolism"], "20446": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "20447": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "20448": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "20449": ["Sialic acid metabolism"], "20450": ["Sialic acid metabolism", "NCAM1 interactions", "N-Glycan antennae elongation"], "20451": ["Sialic acid metabolism", "N-Glycan antennae elongation"], "20452": ["Sialic acid metabolism", "NCAM1 interactions"], "20454": ["Sialic acid metabolism"], "20459": ["SCF(Skp2)-mediated degradation of p27/p21", "Cyclin D associated events in G1", "ERBB2 Activates PTK6 Signaling", "PTK6 Regulates Proteins Involved in RNA Processing", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "PTK6 Regulates Cell Cycle", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "PTK6 Down-Regulation", "PTK6 Activates STAT3", "PTK6 promotes HIF1A stabilization"], "20462": ["mRNA Splicing - Major Pathway"], "20466": ["SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of MECP2 expression and activity"], "20467": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "20469": ["Rap1 signalling"], "20479": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "20481": ["Signaling by BMP", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "20482": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "20492": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "20493": ["Recycling of bile acids and salts"], "20494": ["Recycling of bile acids and salts"], "20496": ["Cation-coupled Chloride cotransporters"], "20497": ["Cation-coupled Chloride cotransporters"], "20498": ["Cation-coupled Chloride cotransporters"], "20499": ["Cation-coupled Chloride cotransporters"], "20500": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "20501": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "20502": ["Transport of organic anions"], "20503": ["Proton-coupled monocarboxylate transport"], "20504": ["Organic anion transporters"], "20505": ["Type II Na+/Pi cotransporters", "Surfactant metabolism"], "20508": ["Acetylcholine Neurotransmitter Release Cycle", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "20509": ["Metabolism of folate and pterines"], "20510": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "20511": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "20512": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "20513": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "20514": ["Amino acid transport across the plasma membrane"], "20515": ["Sodium-coupled phosphate cotransporters"], "20516": ["Sodium-coupled phosphate cotransporters"], "20517": ["Norepinephrine Neurotransmitter Release Cycle", "Abacavir transmembrane transport", "Na+/Cl- dependent neurotransmitter transporters", "Organic cation transport"], "20518": ["Norepinephrine Neurotransmitter Release Cycle", "Abacavir transmembrane transport", "Na+/Cl- dependent neurotransmitter transporters", "Organic cation transport"], "20519": ["Abacavir transmembrane transport", "Organic cation transport"], "20520": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Organic cation transport"], "20521": ["Organic anion transport"], "20522": ["Vitamin C (ascorbate) metabolism"], "20523": ["The fatty acid cycling model", "The proton buffering model"], "20524": ["Alpha-oxidation of phytanate"], "20525": ["Cellular hexose transport", "Vitamin C (ascorbate) metabolism", "Regulation of insulin secretion", "Lactose synthesis"], "20526": ["Cellular hexose transport", "Regulation of insulin secretion", "Intestinal hexose absorption"], "20527": ["Cellular hexose transport", "Vitamin C (ascorbate) metabolism", "Neutrophil degranulation"], "20528": ["Cellular hexose transport"], "20529": ["Metal ion SLC transporters"], "20531": ["Type II Na+/Pi cotransporters", "Surfactant metabolism"], "20532": ["Amino acid transport across the plasma membrane"], "20533": ["Erythrocytes take up carbon dioxide and release oxygen", "Bicarbonate transporters"], "20535": ["Bicarbonate transporters"], "20536": ["Bicarbonate transporters"], "20537": ["Cellular hexose transport", "Intestinal hexose absorption"], "20538": ["Na+/Cl- dependent neurotransmitter transporters"], "20539": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "20540": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "20541": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis"], "20544": ["Hyaluronan uptake and degradation", "Sodium/Proton exchangers"], "20563": ["Signaling by ROBO receptors", "Role of ABL in ROBO-SLIT signaling", "SLIT2:ROBO1 increases RHOA activity", "Regulation of expression of SLITs and ROBOs"], "20564": ["Signaling by ROBO receptors"], "20568": ["Neutrophil degranulation"], "20585": ["E3 ubiquitin ligases ubiquitinate target proteins"], "20586": ["Interleukin-7 signaling", "Formation of the beta-catenin:TCF transactivating complex", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "20587": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "20588": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "20591": ["HDMs demethylate histones"], "20592": ["HDMs demethylate histones"], "20595": ["snRNP Assembly"], "20597": ["Glycosphingolipid metabolism"], "20598": ["Glycosphingolipid metabolism", "TNFR1-mediated ceramide production"], "20602": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "HDACs deacetylate histones", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "20603": ["Metabolism of polyamines"], "20604": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "20605": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "20606": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "20607": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "BBSome-mediated cargo-targeting to cilium"], "20608": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "20609": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "20610": ["SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of DNA replication proteins", "SUMOylation of immune response proteins", "Formation of Incision Complex in GG-NER"], "20612": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "20614": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Other interleukin signaling", "Neutrophil degranulation", "GABA synthesis, release, reuptake and degradation"], "20615": ["Golgi Associated Vesicle Biogenesis"], "20616": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "20619": ["ER-Phagosome pathway", "Clathrin derived vesicle budding", "Neutrophil degranulation"], "20620": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "20624": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "20630": ["mRNA Splicing - Major Pathway"], "20637": ["mRNA Splicing - Major Pathway"], "20638": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "20639": ["mRNA Splicing - Major Pathway"], "20641": ["snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "20646": ["mRNA Splicing - Major Pathway"], "20652": ["LDL clearance"], "20655": ["Platelet degranulation ", "Detoxification of Reactive Oxygen Species"], "20656": ["Transcriptional activation of mitochondrial biogenesis", "Detoxification of Reactive Oxygen Species"], "20657": ["Detoxification of Reactive Oxygen Species"], "20661": ["Golgi Associated Vesicle Biogenesis"], "20662": ["SOS-mediated signalling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signalling to RAS", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "NRAGE signals death through JNK", "Rho GTPase cycle", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "NCAM signaling for neurite out-growth", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "RAF/MAP kinase cascade", "Signal attenuation", "Insulin receptor signalling cascade", "MET activates RAS signaling", "RET signaling", "Interleukin-15 signaling", "Activated NTRK2 signals through FRS2 and FRS3", "Interleukin receptor SHC signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "20663": ["NRAGE signals death through JNK", "Rho GTPase cycle", "Interleukin-15 signaling"], "20668": ["Deactivation of the beta-catenin transactivating complex"], "20671": ["Deactivation of the beta-catenin transactivating complex"], "20674": ["Deactivation of the beta-catenin transactivating complex"], "20675": ["Deactivation of the beta-catenin transactivating complex"], "20677": ["Deactivation of the beta-catenin transactivating complex"], "20679": ["Deactivation of the beta-catenin transactivating complex"], "20680": ["Deactivation of the beta-catenin transactivating complex"], "20682": ["Deactivation of the beta-catenin transactivating complex", "Transcriptional regulation by RUNX2"], "20683": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA polymerase II transcribes snRNA genes", "Estrogen-dependent gene expression"], "20684": ["SUMOylation of DNA damage response and repair proteins"], "20687": ["SUMOylation of transcription factors"], "20690": ["Interaction With Cumulus Cells"], "20692": ["Platelet degranulation ", "ECM proteoglycans", "Scavenging by Class H Receptors"], "20698": ["Sphingolipid de novo biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "VEGFR2 mediated cell proliferation"], "20700": ["Platelet degranulation ", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "20701": ["Platelet degranulation ", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "20702": ["Platelet degranulation ", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "20703": ["Platelet degranulation ", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "20704": ["Platelet degranulation ", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "20708": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "20714": ["Platelet degranulation ", "Neutrophil degranulation"], "20716": ["Platelet degranulation ", "Neutrophil degranulation"], "20717": ["Platelet degranulation ", "Neutrophil degranulation"], "207182": ["Aflatoxin activation and detoxification"], "20719": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "20720": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Dissolution of Fibrin Clot"], "207212": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "207213": ["Hedgehog 'on' state"], "207215": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "20725": ["Dissolution of Fibrin Clot"], "20732": ["MET Receptor Activation"], "20733": ["MET Receptor Activation"], "207352": ["COPII-mediated vesicle transport"], "20737": ["Cell surface interactions at the vascular wall", "Basigin interactions"], "20739": ["NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "20741": ["NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "20742": ["NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "20743": ["MHC class II antigen presentation", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "20747": ["Hedgehog 'on' state"], "20750": ["Degradation of the extracellular matrix", "Signaling by PDGF", "Integrin cell surface interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "20751": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "207521": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "207565": ["CaMK IV-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Activation of RAC1 downstream of NMDARs"], "207592": ["TBC/RABGAPs"], "207596": ["O-glycosylation of TSR domain-containing proteins"], "207618": ["Generic Transcription Pathway"], "20766": ["Formation of the cornified envelope"], "20768": ["Selenocysteine synthesis"], "207728": ["cGMP effects", "G alpha (s) signalling events"], "20773": ["Sphingolipid de novo biosynthesis"], "207742": ["Regulation of FZD by ubiquitination"], "20775": ["Cholesterol biosynthesis"], "207777": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Pregnenolone biosynthesis", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle"], "20778": ["Scavenging by Class B Receptors", "HDL clearance"], "20779": ["Signaling by ERBB2", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signaling by EGFR", "GAB1 signalosome", "Downstream signal transduction", "c-src mediated regulation of Cx43 function and closure of gap junctions", "FCGR activation", "PECAM1 interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "DCC mediated attractive signaling", "GP1b-IX-V activation signalling", "VEGFA-VEGFR2 Pathway", "Thrombin signalling through proteinase activated receptors (PARs)", "RHO GTPases Activate Formins", "RAF activation", "MAP2K and MAPK activation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cyclin D associated events in G1", "RET signaling", "MET activates PTK2 signaling", "Receptor Mediated Mitophagy", "Regulation of RUNX3 expression and activity", "Activated NTRK3 signals through PI3K"], "207839": ["O-linked glycosylation of mucins"], "20787": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "20788": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "207911": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events", "BBSome-mediated cargo-targeting to cilium"], "207920": ["FGFR2 alternative splicing"], "207952": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "207965": ["Protein methylation"], "208043": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "20807": ["RHO GTPases Activate Formins"], "208092": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "20810": ["Metabolism of polyamines"], "20811": ["PTK6 Down-Regulation"], "208117": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "20813": ["Neutrophil degranulation"], "208144": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "208154": ["Costimulation by the CD28 family"], "208188": ["G alpha (q) signalling events"], "20821": ["Regulation of innate immune responses to cytosolic DNA", "Antigen processing: Ubiquitination & Proteasome degradation"], "208211": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "20826": ["Major pathway of rRNA processing in the nucleolus and cytosol", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "208266": ["PKMTs methylate histone lysines"], "208285": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "20833": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Transcription Elongation"], "208366": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "208372": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "20841": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "20842": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins"], "20843": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins"], "20844": ["EGFR downregulation", "Metalloprotease DUBs", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "208449": ["Sphingolipid de novo biosynthesis"], "20845": ["Pregnenolone biosynthesis"], "20846": ["Interleukin-6 signaling", "ISG15 antiviral mechanism", "Signaling by SCF-KIT", "Downstream signal transduction", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "20847": ["Interleukin-20 family signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "20848": ["Interleukin-6 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Downstream signal transduction", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "PTK6 Activates STAT3", "Interleukin-20 family signaling", "MET activates STAT3", "Interleukin-15 signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-37 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling"], "20849": ["Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-21 signaling"], "20850": ["Nuclear signaling by ERBB4", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Downstream signal transduction", "Signaling by Leptin", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Growth hormone receptor signaling"], "20851": ["Interleukin-7 signaling", "Signaling by SCF-KIT", "Downstream signal transduction", "Signaling by Leptin", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Growth hormone receptor signaling"], "208518": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "20852": ["Downstream signal transduction", "STAT6-mediated induction of chemokines", "Interleukin-4 and Interleukin-13 signaling"], "20856": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "20859": ["Cytosolic sulfonation of small molecules"], "208595": ["Mitochondrial transcription termination"], "20860": ["Cytosolic sulfonation of small molecules"], "20861": ["Formation of the cornified envelope"], "20862": ["Formation of the cornified envelope"], "208624": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "208628": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "20863": ["Formation of the cornified envelope"], "208643": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Ribosomal scanning and start codon recognition", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "208650": ["Antigen processing: Ubiquitination & Proteasome degradation"], "208659": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "20866": ["Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "208665": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "20867": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "208677": ["CREB3 factors activate genes"], "20868": ["Neutrophil degranulation"], "20869": ["Energy dependent regulation of mTOR by LKB1-AMPK", "Regulation of TP53 Activity through Phosphorylation"], "208691": ["Hypusine synthesis from eIF5A-lysine"], "208715": ["Cholesterol biosynthesis"], "208727": ["SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "RUNX3 regulates p14-ARF"], "20873": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "208760": ["Passive transport by Aquaporins"], "20877": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Regulation of TP53 Activity through Phosphorylation", "Mitotic Prometaphase"], "20878": ["APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Regulation of PLK1 Activity at G2/M Transition", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "AURKA Activation by TPX2", "Interaction between PHLDA1 and AURKA"], "208795": ["Neutrophil degranulation"], "208836": ["Fanconi Anemia Pathway"], "208846": ["PCP/CE pathway", "RHO GTPases Activate Formins"], "208869": ["NTRK2 activates RAC1", "Factors involved in megakaryocyte development and platelet production"], "20887": ["Cytosolic sulfonation of small molecules"], "208890": ["Multifunctional anion exchangers"], "20890": ["WNT ligand biogenesis and trafficking", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "20892": ["Deposition of new CENPA-containing nucleosomes at the centromere", "Fanconi Anemia Pathway"], "208936": ["O-glycosylation of TSR domain-containing proteins"], "20897": ["The canonical retinoid cycle in rods (twilight vision)"], "208982": ["Synthesis of Ketone Bodies"], "208990": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "20901": ["Downregulation of TGF-beta receptor signaling"], "209027": ["Amino acid synthesis and interconversion (transamination)"], "20907": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Other interleukin signaling", "LGI-ADAM interactions", "GABA synthesis, release, reuptake and degradation"], "20908": ["Other interleukin signaling"], "20909": ["Disinhibition of SNARE formation", "ER-Phagosome pathway", "Clathrin derived vesicle budding", "Other interleukin signaling"], "20910": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "20911": ["Platelet degranulation ", "Other interleukin signaling"], "20912": ["Disinhibition of SNARE formation"], "20916": ["Citric acid cycle (TCA cycle)"], "20917": ["Citric acid cycle (TCA cycle)"], "209176": ["Tryptophan catabolism"], "209200": ["Antigen processing: Ubiquitination & Proteasome degradation"], "20922": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "209225": ["Generic Transcription Pathway"], "209239": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "20924": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "RNA Polymerase II Transcription Elongation", "RNA Pol II CTD phosphorylation and interaction with CE"], "20926": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "20927": ["ATP sensitive Potassium channels", "Regulation of insulin secretion"], "20928": ["ATP sensitive Potassium channels", "ABC-family proteins mediated transport", "Ion homeostasis"], "209294": ["Formation of the cornified envelope"], "209318": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "20932": ["Neutrophil degranulation", "COPI-dependent Golgi-to-ER retrograde traffic"], "209334": ["Resolution of D-loop Structures through Holliday Junction Intermediates"], "209354": ["Recycling of eIF2:GDP"], "209357": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "209361": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "20937": ["PKMTs methylate histone lysines", "SIRT1 negatively regulates rRNA expression"], "209416": ["mRNA Splicing - Major Pathway"], "209456": ["Regulation of TP53 Activity through Association with Co-factors"], "209462": ["Antigen processing: Ubiquitination & Proteasome degradation"], "209512": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "20955": ["Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Interleukin-12 signaling"], "209590": ["Interleukin-23 signaling"], "20963": ["GPVI-mediated activation cascade", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "DAP12 signaling", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated Ca+2 mobilization", "Integrin alphaIIb beta3 signaling", "Interleukin-2 signaling", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "20964": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "20965": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "20969": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Other interleukin signaling", "Retinoid metabolism and transport"], "209692": ["Glyoxylate metabolism and glycine degradation"], "20970": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Retinoid metabolism and transport"], "20971": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Retinoid metabolism and transport"], "20972": ["Neutrophil degranulation"], "209737": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "20975": ["Synthesis of PIPs at the plasma membrane", "Clathrin-mediated endocytosis"], "209773": ["RAB GEFs exchange GTP for GDP on RABs"], "20979": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "GABA synthesis, release, reuptake and degradation"], "20980": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "209815": ["TBC/RABGAPs"], "209837": ["Amino acid transport across the plasma membrane"], "210004": ["O-linked glycosylation of mucins"], "210009": ["Methylation", "Sulfur amino acid metabolism", "Cobalamin (Cbl, vitamin B12) transport and metabolism"], "210044": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "210045": ["Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "210104": ["Generic Transcription Pathway"], "210105": ["Generic Transcription Pathway"], "210108": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "210135": ["Generic Transcription Pathway"], "210148": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "210198": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "210274": ["Neurexins and neuroligins"], "210293": ["Factors involved in megakaryocyte development and platelet production"], "210376": ["Synthesis of PIPs at the plasma membrane"], "210417": ["O-glycosylation of TSR domain-containing proteins"], "210529": ["Processing of Capped Intron-Containing Pre-mRNA"], "210530": ["Collagen biosynthesis and modifying enzymes"], "210582": ["Respiratory electron transport"], "210741": ["Phase 4 - resting membrane potential"], "210766": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "210925": ["RNA polymerase II transcribes snRNA genes"], "210992": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PG", "Synthesis of PA", "Synthesis of PC", "Neutrophil degranulation"], "211007": ["Antigen processing: Ubiquitination & Proteasome degradation"], "211255": ["Regulation of RAS by GAPs", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "211305": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "211323": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "211347": ["Coenzyme A biosynthesis"], "211389": ["Sulfide oxidation to sulfate"], "211429": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA"], "211446": ["Insulin processing", "VxPx cargo-targeting to cilium"], "211468": ["Voltage gated Potassium channels"], "211480": ["Classical Kir channels", "Phase 4 - resting membrane potential"], "211488": ["Degradation of cysteine and homocysteine"], "211586": ["G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Cyclin D associated events in G1", "Transcriptional Regulation by E2F6"], "211651": ["Fanconi Anemia Pathway"], "211652": ["Signaling by Hippo"], "211666": ["Glutathione conjugation"], "211896": ["Rho GTPase cycle"], "211922": ["RAB GEFs exchange GTP for GDP on RABs"], "211924": ["Apoptotic cleavage of cell adhesion  proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "211948": ["OAS antiviral response"], "211949": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "212032": ["Neutrophil degranulation", "Glycolysis"], "212108": ["G alpha (s) signalling events", "G alpha (i) signalling events", "Relaxin receptors"], "212111": ["Synthesis of IP2, IP, and Ins in the cytosol"], "212114": ["Neutrophil degranulation"], "212281": ["Generic Transcription Pathway"], "212285": ["Rho GTPase cycle"], "212398": ["Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "212503": ["PAOs oxidise polyamines to amines", "Interconversion of polyamines", "Peroxisomal protein import"], "212518": ["Post-translational modification: synthesis of GPI-anchored proteins"], "212541": ["The canonical retinoid cycle in rods (twilight vision)", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Opsins", "VxPx cargo-targeting to cilium"], "212555": ["Miscellaneous transport and binding events"], "212647": ["Proline catabolism"], "212670": ["Sperm Motility And Taxes"], "212712": ["SUMOylation of chromatin organization proteins"], "212862": ["Synthesis of PC"], "212880": ["mRNA Splicing - Major Pathway"], "212898": ["Dermatan sulfate biosynthesis"], "212919": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "212980": ["Cellular hexose transport"], "212989": ["Stimuli-sensing channels"], "212996": ["O-linked glycosylation of mucins"], "213002": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "213011": ["Generic Transcription Pathway"], "213012": ["Glucuronidation"], "213053": ["Zinc influx into cells by the SLC39 gene family"], "213081": ["Hedgehog 'off' state", "Intraflagellar transport"], "213119": ["Integrin cell surface interactions"], "213208": ["Interleukin-20 family signaling"], "21333": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "21334": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "21336": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "21337": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "21338": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "21340": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "21341": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "21343": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "21346": ["Platelet degranulation "], "213464": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Neddylation"], "213469": ["LGI-ADAM interactions"], "213484": ["Phosphate bond hydrolysis by NUDT proteins"], "21349": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "213498": ["NRAGE signals death through JNK", "Rho GTPase cycle", "Sema4D induced cell migration and growth-cone collapse"], "21351": ["Pentose phosphate pathway"], "213527": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "21353": ["Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "213539": ["Regulation of HSF1-mediated heat shock response"], "21354": ["ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "21355": ["ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "21356": ["ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "21357": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "213575": ["Intraflagellar transport"], "213603": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "213649": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "21366": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "21372": ["HDACs deacetylate histones", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "21374": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "Estrogen-dependent gene expression"], "213773": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "213788": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "213827": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "21388": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression"], "213895": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "21390": ["Prostanoid ligand receptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "Thromboxane signalling through TP receptor"], "21391": ["Eicosanoids", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "21393": ["Striated Muscle Contraction"], "213945": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "213948": ["Macroautophagy"], "213988": ["Post-transcriptional silencing by small RNAs"], "21399": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "21402": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Iron uptake and transport", "Antigen processing: Ubiquitination & Proteasome degradation"], "21406": ["CDO in myogenesis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "21408": ["Generic Transcription Pathway"], "214084": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Na+/Cl- dependent neurotransmitter transporters"], "214111": ["Sodium/Calcium exchangers"], "214112": ["Miscellaneous transport and binding events"], "21413": ["CDO in myogenesis"], "214137": ["Rho GTPase cycle"], "21414": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "21415": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "214150": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs"], "21416": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "214162": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "21418": ["Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "21419": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "21420": ["SUMOylation of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "21423": ["CDO in myogenesis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "214240": ["Release of Hh-Np from the secreting cell"], "214253": ["Synthesis of PE"], "214254": ["Phosphate bond hydrolysis by NUDT proteins"], "21428": ["ChREBP activates metabolic gene expression"], "21429": ["RNA Polymerase I Promoter Opening", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "214290": ["Deadenylation of mRNA"], "214403": ["Regulation of Complement cascade"], "214424": ["Nicotinamide salvaging"], "214425": ["Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "214444": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "214459": ["Clathrin-mediated endocytosis"], "214498": ["Formation of RNA Pol II elongation complex ", "Formation of the beta-catenin:TCF transactivating complex", "Hedgehog 'on' state", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "21452": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "21454": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "214552": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "214572": ["RMTs methylate histone arginines"], "214579": ["Degradation of GABA"], "214593": ["Thyroxine biosynthesis"], "214639": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "214663": ["Amino acid transport across the plasma membrane"], "214669": ["SUMOylation of chromatin organization proteins", "Transcriptional Regulation by E2F6"], "214804": ["Rho GTPase cycle"], "214895": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "214899": ["HDMs demethylate histones"], "214922": ["Zinc influx into cells by the SLC39 gene family"], "214931": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "214952": ["Rho GTPase cycle"], "214968": ["Other semaphorin interactions"], "215061": ["Antigen processing: Ubiquitination & Proteasome degradation"], "215113": ["Amino acid transport across the plasma membrane"], "215114": ["Clathrin-mediated endocytosis"], "215193": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "215257": ["Interleukin-36 pathway"], "215274": ["Interleukin-38 signaling", "Interleukin-36 pathway"], "215280": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs"], "215335": ["Amino acid transport across the plasma membrane", "Proton-coupled neutral amino acid transporters"], "215387": ["Condensation of Prometaphase Chromosomes"], "215445": ["VxPx cargo-targeting to cilium"], "215446": ["Phosphate bond hydrolysis by NTPDase proteins"], "215456": ["Synthesis of PA", "Triglyceride biosynthesis"], "215474": ["COPII-mediated vesicle transport"], "215494": ["O-linked glycosylation"], "215654": ["Adherens junctions interactions"], "215708": ["Synthesis of PA"], "215789": ["Platelet degranulation "], "215854": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "215855": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "215859": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "215890": ["Lysosome Vesicle Biogenesis"], "215928": ["Cellular hexose transport"], "215929": ["Cellular hexose transport"], "215999": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "216001": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "216028": ["Neurexins and neuroligins"], "216080": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Downstream TCR signaling", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Ovarian tumor domain proteases", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "IKK complex recruitment mediated by RIP1", "Antigen processing: Ubiquitination & Proteasome degradation"], "216131": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "216134": ["Neutrophil degranulation", "Vitamins B6 activation to pyridoxal phosphate"], "216148": ["Signalling to RAS", "VEGFA-VEGFR2 Pathway", "RAF/MAP kinase cascade"], "216150": ["Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "216151": ["Mitochondrial transcription initiation"], "216152": ["Lysosphingolipid and LPA receptors"], "216154": ["Generic Transcription Pathway"], "216156": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "216188": ["Metabolism of folate and pterines"], "216197": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Surfactant metabolism", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "216225": ["Nicotinamide salvaging", "Organic anion transporters"], "216227": ["Organic anion transporters"], "216233": ["Neddylation"], "216238": ["Toll Like Receptor 9 (TLR9) Cascade"], "216274": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "AURKA Activation by TPX2"], "216343": ["Serotonin and melatonin biosynthesis"], "216344": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "216363": ["Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "BBSome-mediated cargo-targeting to cilium", "RAB GEFs exchange GTP for GDP on RABs"], "216440": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "ER Quality Control Compartment (ERQC)"], "216445": ["Rho GTPase cycle", "Neutrophil degranulation"], "216453": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "216454": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "216456": ["Glutamate Neurotransmitter Release Cycle", "TP53 Regulates Metabolic Genes", "Amino acid synthesis and interconversion (transamination)"], "216459": ["Smooth Muscle Contraction"], "21647": ["Intraflagellar transport"], "21648": ["Neutrophil degranulation"], "21652": ["PRC2 methylates histones and DNA"], "216558": ["Formation of the active cofactor, UDP-glucuronate", "Glycogen synthesis"], "216616": ["Molecules associated with elastic fibres"], "216622": ["Neddylation"], "21664": ["Interaction between PHLDA1 and AURKA"], "21665": ["Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1", "SUMOylation of DNA damage response and repair proteins", "TET1,2,3 and TDG demethylate DNA"], "216705": ["Golgi Associated Vesicle Biogenesis"], "21672": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes"], "216724": ["Synthesis of PIPs at the plasma membrane"], "216725": ["Collagen biosynthesis and modifying enzymes", "O-glycosylation of TSR domain-containing proteins"], "216739": ["Synthesis of very long-chain fatty acyl-CoAs"], "21674": ["Deactivation of the beta-catenin transactivating complex"], "216749": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "21676": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "216760": ["Molecules associated with elastic fibres"], "216766": ["snRNP Assembly"], "216767": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "21677": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "21678": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "216783": ["Olfactory Signaling Pathway"], "216795": ["WNT ligand biogenesis and trafficking"], "216799": ["Metalloprotease DUBs", "The NLRP3 inflammasome"], "21682": ["Signaling by SCF-KIT", "FCERI mediated Ca+2 mobilization", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "216825": ["Ub-specific processing proteases"], "21683": ["Post-translational modification: synthesis of GPI-anchored proteins"], "216831": ["Rho GTPase cycle"], "216835": ["Termination of translesion DNA synthesis"], "21684": ["Post-translational modification: synthesis of GPI-anchored proteins"], "216848": ["HDACs deacetylate histones", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "216850": ["Oxidative Stress Induced Senescence", "HDMs demethylate histones"], "216856": ["Neurexins and neuroligins"], "216869": ["G alpha (s) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "WNT5A-dependent internalization of FZD4", "Activation of SMO", "MAP2K and MAPK activation", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "21687": ["Tie2 Signaling", "RAF/MAP kinase cascade"], "216963": ["Ephrin signaling"], "216965": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "216987": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "217057": ["Ub-specific processing proteases"], "217069": ["ISG15 antiviral mechanism", "Termination of translesion DNA synthesis"], "217109": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "217119": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "217127": ["HATs acetylate histones"], "217166": ["Nuclear Receptor transcription pathway"], "217169": ["MET interacts with TNS proteins"], "217194": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "217212": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "217214": ["Urea cycle"], "217217": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "217232": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "217262": ["ABC transporters in lipid homeostasis"], "217265": ["ABC transporters in lipid homeostasis"], "217303": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "217304": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "217305": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "217306": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "217335": ["Anchoring of the basal body to the plasma membrane"], "217342": ["Antigen processing: Ubiquitination & Proteasome degradation"], "217351": ["Post-transcriptional silencing by small RNAs"], "217353": ["Neutrophil degranulation"], "217364": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "217365": ["Translesion Synthesis by POLH"], "217369": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "217371": ["RAB geranylgeranylation"], "217449": ["RAB GEFs exchange GTP for GDP on RABs"], "217480": ["Effects of PIP2 hydrolysis"], "21749": ["DNA Damage/Telomere Stress Induced Senescence"], "21750": ["DNA Damage/Telomere Stress Induced Senescence"], "21752": ["Telomere Extension By Telomerase", "Formation of the beta-catenin:TCF transactivating complex"], "217593": ["Lysine catabolism"], "21762": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "217653": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "217664": ["Reactions specific to the complex N-glycan synthesis pathway"], "217666": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "21767": ["Platelet degranulation "], "217674": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "217698": ["Mitochondrial Fatty Acid Beta-Oxidation", "Peroxisomal protein import"], "21770": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins", "RAF activation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "217700": ["Beta-oxidation of very long chain fatty acids"], "217708": ["G0 and Early G1"], "21771": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "217715": ["Recycling of eIF2:GDP"], "217718": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "217734": ["O-linked glycosylation"], "21780": ["Mitochondrial transcription initiation"], "21781": ["G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Cyclin D associated events in G1", "Transcriptional Regulation by E2F6"], "217826": ["Tandem pore domain halothane-inhibited K+ channel (THIK)", "Phase 4 - resting membrane potential"], "217835": ["RAB GEFs exchange GTP for GDP on RABs"], "217837": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Factors involved in megakaryocyte development and platelet production"], "217843": ["Stimuli-sensing channels"], "217847": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "217864": ["HDACs deacetylate histones", "Factors involved in megakaryocyte development and platelet production"], "217869": ["Ribosomal scanning and start codon recognition"], "21787": ["COPII-mediated vesicle transport"], "21788": ["Extrinsic Pathway of Fibrin Clot Formation"], "217935": ["Intraflagellar transport"], "217995": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "21802": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "COPII-mediated vesicle transport", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "Cargo concentration in the ER", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "21803": ["Platelet degranulation ", "Cell surface interactions at the vascular wall", "Molecules associated with elastic fibres", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Syndecan interactions", "RUNX3 regulates CDKN1A transcription", "Regulation of RUNX3 expression and activity", "RUNX3 regulates p14-ARF"], "218038": ["Clathrin-mediated endocytosis"], "218066": ["Olfactory Signaling Pathway"], "21808": ["Platelet degranulation ", "Molecules associated with elastic fibres"], "21809": ["Platelet degranulation ", "Molecules associated with elastic fibres"], "21812": ["Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Ub-specific processing proteases"], "218121": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PE"], "21813": ["Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "218138": ["GDP-fucose biosynthesis"], "21815": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "21816": ["Formation of the cornified envelope"], "218203": ["VLDLR internalisation and degradation", "Antigen processing: Ubiquitination & Proteasome degradation"], "21821": ["Hedgehog 'off' state", "Intraflagellar transport"], "218210": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "218214": ["HDMs demethylate histones", "UCH proteinases"], "218215": ["Antigen processing: Ubiquitination & Proteasome degradation"], "21823": ["Catecholamine biosynthesis"], "21824": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "21825": ["Platelet degranulation ", "Signaling by PDGF", "Integrin cell surface interactions", "O-glycosylation of TSR domain-containing proteins"], "21826": ["Signaling by PDGF", "O-glycosylation of TSR domain-containing proteins"], "21827": ["Signaling by PDGF"], "218271": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "218275": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "21828": ["Signaling by PDGF"], "218294": ["MAPK6/MAPK4 signaling"], "21833": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "218333": ["RNA polymerase II transcribes snRNA genes"], "21834": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "218343": ["mRNA decay by 3' to 5' exoribonuclease"], "21835": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "21838": ["Post-translational modification: synthesis of GPI-anchored proteins"], "218397": ["Downstream signal transduction", "EPHB-mediated forward signaling", "VEGFR2 mediated cell proliferation", "Regulation of RAS by GAPs", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "21841": ["FGFR2 alternative splicing"], "21843": ["FGFR2 alternative splicing"], "21844": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "EPH-ephrin mediated repulsion of cells"], "218441": ["Signaling by BMP"], "218442": ["Serine biosynthesis"], "218454": ["Platelet degranulation "], "218476": ["O-linked glycosylation of mucins"], "21849": ["Generic Transcription Pathway"], "218503": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "218506": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "21853": ["Processing of DNA double-strand break ends"], "21857": ["Platelet degranulation ", "Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "21858": ["Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "218581": ["Rho GTPase cycle"], "21859": ["Platelet degranulation "], "218624": ["IL-6-type cytokine receptor ligand interactions"], "218693": ["Deadenylation of mRNA"], "21871": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "21872": ["c-src mediated regulation of Cx43 function and closure of gap junctions", "Signaling by Hippo", "Apoptotic cleavage of cell adhesion  proteins"], "21873": ["Signaling by Hippo", "Apoptotic cleavage of cell adhesion  proteins"], "218756": ["Bicarbonate transporters"], "21877": ["Pyrimidine salvage"], "218772": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "218793": ["Antigen processing: Ubiquitination & Proteasome degradation"], "21881": ["Pentose phosphate pathway"], "218811": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "218832": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "21884": ["Triglyceride catabolism"], "21885": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes"], "21886": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes"], "218865": ["Choline catabolism"], "21887": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Estrogen-dependent gene expression"], "21888": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes"], "218914": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "21892": ["Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation"], "21894": ["Platelet degranulation ", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "Smooth Muscle Contraction", "MAP2K and MAPK activation"], "218952": ["Cell-extracellular matrix interactions"], "21897": ["Beta defensins", "Regulation of TLR by endogenous ligand"], "21898": ["Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "Regulation of TLR by endogenous ligand", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "21899": ["Regulation of TLR by endogenous ligand"], "219022": ["Regulation of TP53 Activity through Methylation"], "219024": ["PI5P Regulates TP53 Acetylation", "Synthesis of PIPs in the nucleus"], "219033": ["Adherens junctions interactions"], "21907": ["Nuclear Receptor transcription pathway"], "219072": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "219103": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "AURKA Activation by TPX2"], "21912": ["Trafficking of GluR2-containing AMPA receptors"], "219135": ["Synthesis of PIPs at the plasma membrane"], "21915": ["Interconversion of nucleotide di- and triphosphates"], "219158": ["Regulation of HSF1-mediated heat shock response"], "21916": ["Striated Muscle Contraction"], "21917": ["Depolymerisation of the Nuclear Lamina"], "21922": ["Platelet degranulation "], "21923": ["Integrin cell surface interactions", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "21924": ["Striated Muscle Contraction"], "21925": ["Striated Muscle Contraction"], "21926": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production", "TNFR2 non-canonical NF-kB pathway", "TNF signaling"], "21929": ["NOD1/2 Signaling Pathway", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ovarian tumor domain proteases", "Negative regulators of DDX58/IFIH1 signaling"], "21930": ["Neutrophil degranulation"], "21933": ["Cell surface interactions at the vascular wall", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "TRAIL  signaling"], "21934": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "21935": ["TNFs bind their physiological receptors"], "21936": ["TNFs bind their physiological receptors"], "21937": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production", "TNFs bind their physiological receptors", "TNF signaling"], "21938": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "Neutrophil degranulation"], "21939": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "21940": ["TNFs bind their physiological receptors"], "21941": ["TNFs bind their physiological receptors"], "21942": ["TNFs bind their physiological receptors"], "21943": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "21944": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "21946": ["Neutrophil degranulation", "Antimicrobial peptides"], "21947": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "21948": ["TNFs bind their physiological receptors"], "21949": ["TNFs bind their physiological receptors"], "21950": ["TNFs bind their physiological receptors"], "21951": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "21952": ["Striated Muscle Contraction"], "21953": ["Striated Muscle Contraction"], "21954": ["Striated Muscle Contraction", "Ion homeostasis"], "21955": ["Striated Muscle Contraction"], "21956": ["Striated Muscle Contraction"], "21957": ["Striated Muscle Contraction"], "21960": ["ECM proteoglycans"], "21968": ["Neutrophil degranulation"], "21969": ["SUMOylation of DNA replication proteins"], "21973": ["SUMOylation of DNA replication proteins"], "21974": ["SUMOylation of DNA replication proteins"], "21975": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "21981": ["Regulation of TP53 Activity through Association with Co-factors"], "21985": ["Golgi Associated Vesicle Biogenesis"], "21987": ["Golgi Associated Vesicle Biogenesis"], "21990": ["Serotonin and melatonin biosynthesis"], "21991": ["Glycolysis"], "22003": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "22004": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "22017": ["Methylation"], "22018": ["Thyroxine biosynthesis"], "22019": ["Antigen processing: Ubiquitination & Proteasome degradation"], "22021": ["Cytosolic sulfonation of small molecules"], "22022": ["Cytosolic sulfonation of small molecules"], "22025": ["Nuclear Receptor transcription pathway"], "22026": ["Nuclear Receptor transcription pathway"], "22027": ["Trafficking and processing of endosomal TLR", "Scavenging by Class A Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Interleukin-4 and Interleukin-13 signaling", "Post-translational protein phosphorylation"], "22029": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "22030": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "Dimerization of procaspase-8", "TNF signaling"], "22031": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ovarian tumor domain proteases", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "22034": ["PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "NOD1/2 Signaling Pathway", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "MyD88 dependent cascade initiated on endosome", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "MyD88 cascade initiated on plasma membrane"], "22035": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "TRAIL  signaling"], "22036": ["Antigen processing: Ubiquitination & Proteasome degradation"], "22041": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Post-translational protein phosphorylation", "Iron uptake and transport", "Transferrin endocytosis and recycling"], "22042": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Transferrin endocytosis and recycling"], "22044": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "22045": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "22059": ["Oxidative Stress Induced Senescence", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "Oncogene Induced Senescence", "DNA Damage/Telomere Stress Induced Senescence", "Autodegradation of the E3 ubiquitin ligase COP1", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Regulation of TP53 Expression", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Association with Co-factors", "Regulation of TP53 Activity through Methylation", "PI5P Regulates TP53 Acetylation", "G2/M DNA damage checkpoint", "G2/M Checkpoints", "Stabilization of p53", "Transcriptional  activation of  cell cycle inhibitor p21 ", "The role of GTSE1 in G2/M progression after G2 checkpoint", "RUNX3 regulates CDKN1A transcription"], "22061": ["Regulation of TP53 Activity through Association with Co-factors"], "22062": ["Regulation of TP53 Activity through Association with Co-factors", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "22063": ["TRP channels", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "22065": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels"], "22066": ["TRP channels"], "22067": ["TRP channels"], "22068": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels"], "22072": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "22073": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "22074": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "22083": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "22084": ["Macroautophagy", "Inhibition of TSC complex formation by PKB", "AKT phosphorylates targets in the cytosol", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "TBC/RABGAPs"], "22088": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "22094": ["Glycoprotein hormones", "Thyroxine biosynthesis", "Hormone ligand-binding receptors", "G alpha (s) signalling events"], "22095": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "22099": ["Small interfering RNA (siRNA) biogenesis"], "22117": ["Degradation of cysteine and homocysteine"], "22121": ["L13a-mediated translational silencing of Ceruloplasmin expression"], "22122": ["GDP-fucose biosynthesis"], "22123": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "22130": ["Surfactant metabolism", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Termination"], "22134": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Golgi Associated Vesicle Biogenesis", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Post-translational protein phosphorylation"], "22139": ["The canonical retinoid cycle in rods (twilight vision)", "Non-integrin membrane-ECM interactions", "Neutrophil degranulation", "Retinoid metabolism and transport"], "22142": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "22143": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "22145": ["Platelet degranulation ", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "22146": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "22151": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "22152": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "22153": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "22154": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "AURKA Activation by TPX2"], "22158": ["Hedgehog 'off' state"], "22163": ["TNFs bind their physiological receptors"], "22164": ["TNFs bind their physiological receptors"], "22165": ["FCERI mediated Ca+2 mobilization"], "22166": ["Oxidative Stress Induced Senescence", "Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "TP53 Regulates Metabolic Genes", "Protein repair", "The NLRP3 inflammasome"], "22171": ["Interconversion of nucleotide di- and triphosphates"], "22173": ["Melanin biosynthesis"], "22177": ["DAP12 interactions", "DAP12 signaling", "Signal regulatory protein family interactions", "Other semaphorin interactions", "Neutrophil degranulation"], "22178": ["Melanin biosynthesis"], "22183": ["mRNA Splicing - Minor Pathway"], "22184": ["mRNA Splicing - Minor Pathway"], "22185": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "22186": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "NOD1/2 Signaling Pathway", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC-Cdc20 mediated degradation of Nek2A", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Stimuli-sensing channels", "FCERI mediated NF-kB activation", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "ABC-family proteins mediated transport", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "Interleukin-1 signaling", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "22190": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "NOD1/2 Signaling Pathway", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC-Cdc20 mediated degradation of Nek2A", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Stimuli-sensing channels", "FCERI mediated NF-kB activation", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "ABC-family proteins mediated transport", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "Interleukin-1 signaling", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "22192": ["TGF-beta receptor signaling activates SMADs", "Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "22193": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "22194": ["ISG15 antiviral mechanism", "Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "22196": ["Vitamin D (calciferol) metabolism", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "22200": ["Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "22201": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "22209": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "22210": ["Recognition of DNA damage by PCNA-containing replication complex", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "22213": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "22214": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "22215": ["Antigen processing: Ubiquitination & Proteasome degradation"], "22217": ["Ub-specific processing proteases"], "22218": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "Regulation of IFNG signaling", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "22222": ["Antigen processing: Ubiquitination & Proteasome degradation"], "22223": ["UCH proteinases"], "22224": ["Termination of translesion DNA synthesis", "Ub-specific processing proteases"], "22225": ["Ub-specific processing proteases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "22226": ["Class B/2 (Secretin family receptors)"], "22227": ["The fatty acid cycling model", "The proton buffering model"], "22228": ["The fatty acid cycling model", "The proton buffering model"], "22229": ["The fatty acid cycling model", "The proton buffering model"], "22230": ["Translesion Synthesis by POLH", "Ub-specific processing proteases"], "22232": ["Transport of nucleotide sugars"], "22234": ["Glycosphingolipid metabolism"], "22235": ["Formation of the active cofactor, UDP-glucuronate"], "22236": ["Glucuronidation", "Heme degradation"], "22238": ["Glucuronidation"], "22239": ["Glycosphingolipid metabolism"], "22240": ["CRMPs in Sema3A signaling"], "22241": ["Macroautophagy", "TBC/RABGAPs", "RAB GEFs exchange GTP for GDP on RABs", "Receptor Mediated Mitophagy"], "22242": ["Asparagine N-linked glycosylation"], "22245": ["Pyrimidine salvage"], "22247": ["Pyrimidine biosynthesis"], "22249": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle"], "22256": ["Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "22258": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases"], "22259": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "VLDLR internalisation and degradation"], "22260": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "VLDLR internalisation and degradation"], "22271": ["Pyrimidine salvage"], "22275": ["Heme biosynthesis"], "22276": ["Heme biosynthesis"], "22278": ["Estrogen-dependent gene expression"], "22282": ["Estrogen-dependent gene expression"], "22284": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Ub-specific processing proteases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Peroxisomal protein import"], "22289": ["HDMs demethylate histones"], "22290": ["HDMs demethylate histones"], "22293": ["Melanin biosynthesis"], "22318": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Other interleukin signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "GABA synthesis, release, reuptake and degradation"], "22319": ["ER-Phagosome pathway", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "22320": ["ER-Phagosome pathway", "Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "22323": ["Signaling by ROBO receptors", "Cell-extracellular matrix interactions"], "22324": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "CD28 dependent Vav1 pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "VEGFR2 mediated vascular permeability", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Erythropoietin activates RAS", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "22325": ["GPVI-mediated activation cascade", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "EPH-ephrin mediated repulsion of cells", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability"], "223255": ["Apoptotic cleavage of cellular proteins", "Apoptotic execution phase"], "22330": ["Platelet degranulation ", "Smooth Muscle Contraction", "MAP2K and MAPK activation", "Neutrophil degranulation"], "22333": ["Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases", "Pyruvate metabolism"], "223337": ["Glucuronidation"], "22334": ["Ub-specific processing proteases"], "22335": ["Ub-specific processing proteases"], "22337": ["Vitamin D (calciferol) metabolism", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "22339": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated cell proliferation"], "22340": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "22341": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "22342": ["Dopamine Neurotransmitter Release Cycle", "RHO GTPases Activate Rhotekin and Rhophilins"], "22343": ["Dopamine Neurotransmitter Release Cycle"], "223435": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (q) signalling events", "DCC mediated attractive signaling"], "223455": ["ER Quality Control Compartment (ERQC)"], "22346": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "SUMOylation of ubiquitinylation proteins", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "223473": ["Miscellaneous transport and binding events"], "22348": ["Transport of inorganic cations/anions and amino acids/oligopeptides", "GABA synthesis, release, reuptake and degradation"], "223499": ["Major pathway of rRNA processing in the nucleolus and cytosol", "Neddylation"], "22350": ["Netrin-1 signaling", "Recycling pathway of L1"], "22352": ["Caspase-mediated cleavage of cytoskeletal proteins", "Striated Muscle Contraction"], "22353": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "22354": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "22355": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "22359": ["Reelin signalling pathway", "VLDLR internalisation and degradation", "VLDL clearance"], "223601": ["Platelet degranulation "], "223604": ["TWIK-releated acid-sensitive K+ channel (TASK)", "Phase 4 - resting membrane potential"], "22361": ["Post-translational modification: synthesis of GPI-anchored proteins", "Vitamin B5 (pantothenate) metabolism", "Neutrophil degranulation"], "22362": ["Cell surface interactions at the vascular wall"], "22363": ["Cell surface interactions at the vascular wall"], "22364": ["Cell surface interactions at the vascular wall"], "223646": ["Nicotinamide salvaging", "Neutrophil degranulation"], "22365": ["Intra-Golgi traffic", "Factors involved in megakaryocyte development and platelet production"], "223666": ["Rho GTPase cycle"], "22367": ["Initiation of Nuclear Envelope Reformation"], "223672": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "22368": ["TRP channels"], "223691": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "223696": ["Pink/Parkin Mediated Mitophagy"], "22370": ["Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "ECM proteoglycans", "Regulation of Complement cascade"], "223701": ["SUMOylation of transcription cofactors", "RHO GTPases Activate Formins"], "223706": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "22371": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "GP1b-IX-V activation signalling", "MAP2K and MAPK activation", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "223722": ["Mitochondrial Fatty Acid Beta-Oxidation"], "223723": ["Carboxyterminal post-translational modifications of tubulin"], "223753": ["Glycosphingolipid metabolism"], "22376": ["Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs"], "223770": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "223774": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "223780": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "22379": ["RHO GTPases Activate Formins"], "22380": ["mRNA Splicing - Major Pathway"], "223838": ["O-glycosylation of TSR domain-containing proteins"], "22384": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Ribosomal scanning and start codon recognition"], "22385": ["B-WICH complex positively regulates rRNA expression", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "223864": ["Integrin alphaIIb beta3 signaling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion"], "223870": ["SUMO is proteolytically processed"], "22388": ["Platelet degranulation "], "223881": ["Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse"], "22390": ["Polo-like kinase mediated events", "Cyclin E associated events during G1/S transition "], "223915": ["Keratinization", "Formation of the cornified envelope"], "223917": ["Keratinization", "Formation of the cornified envelope"], "223920": ["LDL clearance"], "223921": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "22393": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "223970": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "223978": ["Neutrophil degranulation"], "224008": ["Resolution of D-loop Structures through Holliday Junction Intermediates"], "224014": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "224020": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the Golgi membrane"], "224023": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "224045": ["Recycling of eIF2:GDP"], "224055": ["Olfactory Signaling Pathway"], "224065": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "224079": ["Ion transport by P-type ATPases"], "22408": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "PCP/CE pathway", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "22409": ["WNT ligand biogenesis and trafficking"], "22410": ["WNT ligand biogenesis and trafficking"], "224105": ["Generation of second messenger molecules", "FCERI mediated MAPK activation", "CD28 dependent Vav1 pathway", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "VEGFA-VEGFR2 Pathway", "Smooth Muscle Contraction", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling"], "22411": ["WNT ligand biogenesis and trafficking", "Ca2+ pathway", "PCP/CE pathway"], "224111": ["Neddylation"], "224116": ["MET activates RAS signaling", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "22412": ["WNT ligand biogenesis and trafficking"], "224129": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "22413": ["WNT ligand biogenesis and trafficking"], "224139": ["Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport"], "22414": ["WNT ligand biogenesis and trafficking"], "22415": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking"], "22416": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination"], "22417": ["WNT ligand biogenesis and trafficking", "PCP/CE pathway"], "224170": ["Antigen processing: Ubiquitination & Proteasome degradation"], "22418": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "Ca2+ pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "22419": ["WNT ligand biogenesis and trafficking", "PCP/CE pathway"], "22420": ["WNT ligand biogenesis and trafficking"], "22421": ["WNT ligand biogenesis and trafficking"], "22422": ["WNT ligand biogenesis and trafficking"], "22423": ["WNT ligand biogenesis and trafficking", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "22427": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "22428": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "22436": ["Purine catabolism", "Butyrophilin (BTN) family interactions"], "22439": ["Peptide ligand-binding receptors"], "224480": ["RHO GTPases Activate NADPH Oxidases"], "224530": ["Cholesterol biosynthesis"], "224585": ["Generic Transcription Pathway"], "224619": ["Antigen processing: Ubiquitination & Proteasome degradation"], "224624": ["RAB geranylgeranylation"], "224630": ["COPI-dependent Golgi-to-ER retrograde traffic"], "224640": ["Depolymerisation of the Nuclear Lamina"], "224674": ["Gluconeogenesis"], "224697": ["O-glycosylation of TSR domain-containing proteins"], "224705": ["Retrograde transport at the Trans-Golgi-Network"], "224742": ["ABC-family proteins mediated transport"], "224756": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "224792": ["Surfactant metabolism"], "224794": ["Neutrophil degranulation"], "224814": ["ABC-family proteins mediated transport"], "224823": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "224824": ["Peroxisomal protein import"], "224826": ["Antigen processing: Ubiquitination & Proteasome degradation"], "224840": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "224903": ["SUMOylation of transcription cofactors"], "224912": ["Tight junction interactions"], "224938": ["Antigen processing: Ubiquitination & Proteasome degradation"], "224997": ["Neurexins and neuroligins"], "225010": ["Acyl chain remodeling of CL", "Synthesis of PA"], "225027": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "225030": ["Voltage gated Potassium channels"], "225055": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "225131": ["E3 ubiquitin ligases ubiquitinate target proteins"], "225152": ["Gap junction assembly"], "225160": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "225182": ["HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "225192": ["Histamine receptors", "G alpha (i) signalling events"], "225256": ["Apoptotic cleavage of cell adhesion  proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "225280": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "225283": ["RNA polymerase II transcribes snRNA genes"], "225326": ["PI3K Cascade", "Macroautophagy", "Synthesis of PIPs at the early endosome membrane", "Toll Like Receptor 9 (TLR9) Cascade", "RHO GTPases Activate NADPH Oxidases"], "225348": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "225358": ["Rho GTPase cycle"], "225362": ["Olfactory Signaling Pathway"], "225363": ["Eukaryotic Translation Termination"], "225471": ["Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "Neutrophil degranulation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "225579": ["Transport of fatty acids"], "225600": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway"], "225642": ["Peptide ligand-binding receptors", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events"], "225655": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "225659": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "225724": ["MAPK6/MAPK4 signaling"], "225742": ["Sialic acid metabolism"], "225745": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "225825": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "225845": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI"], "225849": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins", "RAF activation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "225865": ["Sperm Motility And Taxes"], "225870": ["RAB GEFs exchange GTP for GDP on RABs"], "225875": ["Synaptic adhesion-like molecules"], "225876": ["HDMs demethylate histones"], "225887": ["Respiratory electron transport", "Complex I biogenesis"], "225888": ["PKMTs methylate histone lysines"], "225896": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "22590": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER"], "22591": ["SUMOylation of DNA damage response and repair proteins", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "225913": ["Fructose catabolism"], "22592": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER"], "225929": ["mRNA decay by 5' to 3' exoribonuclease"], "22594": ["Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "HDR through MMEJ (alt-NHEJ)", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "22596": ["Nonhomologous End-Joining (NHEJ)", "Neutrophil degranulation"], "22598": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "22599": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "225994": ["Nicotinate metabolism"], "225997": ["TRP channels"], "225998": ["Nuclear Receptor transcription pathway"], "22601": ["Nuclear signaling by ERBB4", "Signaling by Hippo", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX3 regulates YAP1-mediated transcription"], "226025": ["TRP channels"], "226026": ["SUMOylation of DNA damage response and repair proteins"], "22608": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Noncanonical activation of NOTCH3"], "226098": ["Antigen processing: Ubiquitination & Proteasome degradation"], "22612": ["Signaling by ERBB2", "Signaling by SCF-KIT", "Regulation of KIT signaling", "FCGR activation", "PECAM1 interactions", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "Regulation of signaling by CBL"], "226139": ["Heme biosynthesis"], "226144": ["ABC-family proteins mediated transport"], "226182": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "22627": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Signaling by Hippo", "NADE modulates death signalling", "Regulation of PLK1 Activity at G2/M Transition", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "AURKA Activation by TPX2", "RAB GEFs exchange GTP for GDP on RABs"], "226278": ["Peptide ligand-binding receptors"], "22628": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "AURKA Activation by TPX2", "Regulation of localization of FOXO transcription factors"], "22629": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "22630": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "226304": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "22631": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Deactivation of the beta-catenin transactivating complex", "Rap1 signalling", "GP1b-IX-V activation signalling", "KSRP (KHSRP) binds and destabilizes mRNA", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Regulation of localization of FOXO transcription factors"], "22632": ["UCH proteinases", "DNA Damage Recognition in GG-NER", "Estrogen-dependent gene expression"], "226352": ["Neurexins and neuroligins"], "22637": ["Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules"], "22640": ["Generic Transcription Pathway"], "226407": ["COPI-independent Golgi-to-ER retrograde traffic", "RAB GEFs exchange GTP for GDP on RABs"], "226413": ["Digestion of dietary carbohydrate"], "226418": ["Ovarian tumor domain proteases"], "226421": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "226422": ["RAB geranylgeranylation"], "22644": ["ER Quality Control Compartment (ERQC)"], "22648": ["Generic Transcription Pathway"], "226517": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "226518": ["Nicotinate metabolism"], "226519": ["Laminin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "226525": ["Regulation of RAS by GAPs"], "22654": ["Generic Transcription Pathway"], "226541": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "226548": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "22658": ["SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "Transcriptional Regulation by E2F6"], "226641": ["ATF6 (ATF6-alpha) activates chaperones"], "226646": ["Respiratory electron transport", "Complex I biogenesis"], "226652": ["Rho GTPase cycle"], "226654": ["Sulfide oxidation to sulfate"], "226695": ["Neutrophil degranulation"], "226747": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "22678": ["Generic Transcription Pathway"], "226781": ["Metal ion SLC transporters"], "226830": ["PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation"], "226844": ["Iron uptake and transport"], "226849": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins", "RAF activation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "226856": ["Acyl chain remodelling of PG"], "226861": ["Hedgehog ligand biogenesis"], "226866": ["O-glycosylation of TSR domain-containing proteins"], "22689": ["Generic Transcription Pathway"], "226896": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "22690": ["Generic Transcription Pathway"], "226922": ["Voltage gated Potassium channels"], "22693": ["Generic Transcription Pathway"], "22696": ["Generic Transcription Pathway"], "226970": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "226976": ["HATs acetylate histones"], "226977": ["MHC class II antigen presentation", "Neutrophil degranulation"], "226999": ["Sodium/Proton exchangers"], "22704": ["Generic Transcription Pathway"], "227095": ["Branched-chain amino acid catabolism"], "227102": ["Sphingolipid de novo biosynthesis"], "227154": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "227195": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "227197": ["Respiratory electron transport", "Complex I biogenesis"], "227231": ["Urea cycle"], "227289": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (s) signalling events"], "227326": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "227327": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "227333": ["Effects of PIP2 hydrolysis"], "227377": ["SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "227394": ["Neutrophil degranulation", "Transport of organic anions"], "227399": ["Synthesis of pyrophosphates in the cytosol"], "22750": ["Generic Transcription Pathway"], "22751": ["Generic Transcription Pathway"], "227522": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "227525": ["Nonhomologous End-Joining (NHEJ)"], "22755": ["Generic Transcription Pathway"], "22756": ["Generic Transcription Pathway"], "22757": ["Generic Transcription Pathway"], "22761": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Factors involved in megakaryocyte development and platelet production"], "227612": ["Platelet degranulation "], "227613": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "22762": ["Factors involved in megakaryocyte development and platelet production"], "227644": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "227648": ["COPII-mediated vesicle transport"], "227659": ["Cellular hexose transport"], "227697": ["Synthesis of Dolichyl-phosphate"], "227699": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "227715": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "227717": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "227720": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "HuR (ELAVL1) binds and stabilizes mRNA", "SUMOylation of DNA replication proteins"], "227738": ["Antigen processing: Ubiquitination & Proteasome degradation"], "227743": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "227746": ["Retrograde transport at the Trans-Golgi-Network"], "22775": ["Generic Transcription Pathway"], "227753": ["Caspase-mediated cleavage of cytoskeletal proteins", "Neutrophil degranulation"], "22776": ["Generic Transcription Pathway"], "227800": ["TBC/RABGAPs"], "227801": ["RAB GEFs exchange GTP for GDP on RABs"], "22782": ["Zinc efflux and compartmentalization by the SLC30 family"], "22786": ["Interaction With The Zona Pellucida"], "22787": ["Interaction With The Zona Pellucida"], "22788": ["Interaction With The Zona Pellucida"], "22791": ["Regulation of HSF1-mediated heat shock response"], "227937": ["Keratinization", "Formation of the cornified envelope"], "227960": ["Neutrophil degranulation"], "228003": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "228026": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "228033": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "228061": ["Plasmalogen biosynthesis", "Peroxisomal protein import"], "228139": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "228140": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "228355": ["Regulation of TNFR1 signaling", "RAB GEFs exchange GTP for GDP on RABs"], "228359": ["Rho GTPase cycle"], "228361": ["Macroautophagy"], "228366": ["O-linked glycosylation"], "228368": ["GDP-fucose biosynthesis", "Transport of nucleotide sugars"], "228410": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "228421": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "228432": ["Stimuli-sensing channels"], "228482": ["Rho GTPase cycle"], "228491": ["Generic Transcription Pathway"], "228543": ["Rho GTPase cycle"], "228550": ["Synthesis of IP3 and IP4 in the cytosol"], "228607": ["Negative regulators of DDX58/IFIH1 signaling"], "228608": ["PAOs oxidise polyamines to amines", "Interconversion of polyamines"], "228677": ["Sphingolipid de novo biosynthesis"], "228769": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "228770": ["Regulation of FZD by ubiquitination"], "228775": ["PIP3 activates AKT signaling", "Activation of AKT2", "Negative regulation of the PI3K/AKT network", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "228790": ["UCH proteinases"], "228796": ["Antimicrobial peptides"], "228801": ["Antimicrobial peptides"], "228829": ["HATs acetylate histones", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Association with Co-factors", "Stabilization of p53"], "228836": ["Neurexins and neuroligins"], "228839": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "228859": ["Lipid particle organization"], "228876": ["Generic Transcription Pathway"], "228913": ["Estrogen-dependent gene expression"], "228960": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "228980": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "228983": ["Synthesis of bile acids and bile salts"], "228998": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Clathrin-mediated endocytosis"], "229003": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "229211": ["Complex I biogenesis"], "229214": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "229277": ["Stimuli-sensing channels"], "229279": ["mRNA Splicing - Major Pathway"], "229363": ["Purine ribonucleoside monophosphate biosynthesis"], "229445": ["MHC class II antigen presentation"], "229512": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "229521": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "229541": ["RAB GEFs exchange GTP for GDP on RABs"], "229542": ["HDACs deacetylate histones", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "229543": ["RNA polymerase II transcribes snRNA genes"], "229571": ["Hedgehog 'on' state"], "229595": ["O-glycosylation of TSR domain-containing proteins"], "229603": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ovarian tumor domain proteases"], "229615": ["SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "Formation of Incision Complex in GG-NER"], "229665": ["Purine salvage"], "229687": ["Digestion of dietary carbohydrate"], "229688": ["Digestion of dietary carbohydrate"], "229709": ["Ion homeostasis"], "229776": ["Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "MAPK6/MAPK4 signaling"], "229782": ["Transport of nucleotide sugars"], "229791": ["Lysosphingolipid and LPA receptors"], "229841": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "229906": ["RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "229933": ["Stimuli-sensing channels"], "229949": ["Interconversion of nucleotide di- and triphosphates"], "230027": ["Ubiquinol biosynthesis"], "230073": ["ISG15 antiviral mechanism", "Ub-specific processing proteases", "OAS antiviral response", "Negative regulators of DDX58/IFIH1 signaling"], "230075": ["Respiratory electron transport", "Complex I biogenesis"], "230082": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "230098": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "230099": ["Reversible hydration of carbon dioxide"], "230101": ["Glycosphingolipid metabolism"], "230103": ["Physiological factors"], "230126": ["VEGFA-VEGFR2 Pathway"], "230145": ["O-linked glycosylation of mucins"], "230162": ["Generic Transcription Pathway"], "230163": ["Gluconeogenesis", "Fructose catabolism"], "230376": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "230379": ["Sphingolipid de novo biosynthesis"], "230396": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "230398": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "230459": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "230484": ["Recognition of DNA damage by PCNA-containing replication complex", "Fanconi Anemia Pathway"], "230558": ["Terminal pathway of complement", "Regulation of Complement cascade"], "230582": ["Erythrocytes take up carbon dioxide and release oxygen"], "230594": ["Deadenylation of mRNA"], "230596": ["mRNA Splicing - Major Pathway"], "230597": ["TGF-beta receptor signaling activates SMADs"], "230612": ["Cellular hexose transport"], "230639": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "230654": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "230674": ["HDMs demethylate histones", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "230718": ["Pyrimidine catabolism"], "230777": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "230779": ["Serine biosynthesis"], "230784": ["TP53 Regulates Metabolic Genes"], "230796": ["Neddylation"], "230801": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "230815": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "230828": ["Interleukin-20 family signaling"], "230857": ["Peptide ligand-binding receptors"], "230861": ["ISG15 antiviral mechanism"], "230899": ["Physiological factors"], "230903": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "230904": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "230972": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "230979": ["Costimulation by the CD28 family", "TNFs bind their physiological receptors"], "231042": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "231050": ["O-linked glycosylation of mucins"], "231051": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "231086": ["Acyl chain remodeling of CL", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "231103": ["Regulation of Glucokinase by Glucokinase Regulatory Protein"], "231123": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "231130": ["MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Ovarian tumor domain proteases"], "231151": ["Ub-specific processing proteases"], "231214": ["Anchoring of the basal body to the plasma membrane"], "231252": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "231327": ["Purine ribonucleoside monophosphate biosynthesis"], "231329": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "231380": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "231396": ["Glucuronidation"], "231464": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "231474": ["Negative regulation of MAPK pathway"], "231506": ["G0 and Early G1"], "231507": ["Neutrophil degranulation"], "231510": ["Synthesis of PA"], "231532": ["Rho GTPase cycle"], "231549": ["Miscellaneous transport and binding events"], "231571": ["RNA polymerase II transcribes snRNA genes"], "231580": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "231583": ["Transport and synthesis of PAPS", "Multifunctional anion exchangers"], "231602": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "231605": ["O-linked glycosylation of mucins"], "231655": ["OAS antiviral response"], "231670": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "231672": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "231691": ["Threonine catabolism"], "231724": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "231727": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "231805": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "231863": ["FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "231866": ["Generic Transcription Pathway"], "231871": ["Arachidonate production from DAG"], "231874": ["RAB GEFs exchange GTP for GDP on RABs"], "231887": ["Neutrophil degranulation"], "231889": ["mRNA Splicing - Major Pathway"], "231999": ["Synthesis of PIPs at the plasma membrane"], "232087": ["Methylation"], "232146": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "232156": ["Bicarbonate transporters"], "232157": ["Signaling by Hippo"], "232174": ["Vitamins"], "232201": ["Rho GTPase cycle"], "232286": ["Retrograde transport at the Trans-Golgi-Network"], "232314": ["Processing of DNA double-strand break ends"], "232333": ["Na+/Cl- dependent neurotransmitter transporters", "Reuptake of GABA"], "232341": ["Stimuli-sensing channels"], "232345": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Degradation of the extracellular matrix", "Rho GTPase cycle", "HDL assembly"], "232413": ["Neutrophil degranulation"], "232440": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "232449": ["Neutrophil degranulation", "Pentose phosphate pathway"], "232493": ["Glycogen synthesis"], "232536": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "232539": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "232714": ["Digestion of dietary carbohydrate", "Neutrophil degranulation"], "232784": ["Generic Transcription Pathway"], "232790": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "232791": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "232811": ["PKMTs methylate histone lysines"], "232854": ["Generic Transcription Pathway"], "232889": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PI", "Hydrolysis of LPE"], "232906": ["Rho GTPase cycle", "Sema4D mediated inhibition of cell attachment and migration", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "232910": ["Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "232943": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "232944": ["Anchoring of the basal body to the plasma membrane"], "232946": ["Golgi Associated Vesicle Biogenesis"], "232966": ["Generic Transcription Pathway"], "232973": ["Post-translational modification: synthesis of GPI-anchored proteins"], "232975": ["Ion homeostasis", "Ion transport by P-type ATPases"], "232984": ["O-linked glycosylation of mucins"], "232987": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "232989": ["mRNA Splicing - Major Pathway"], "233011": ["Synthesis of IP3 and IP4 in the cytosol"], "233016": ["Heme degradation"], "233040": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "233046": ["RAF/MAP kinase cascade"], "233056": ["Generic Transcription Pathway"], "233057": ["Generic Transcription Pathway"], "233058": ["Generic Transcription Pathway", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "233060": ["Generic Transcription Pathway"], "233067": ["Synaptic adhesion-like molecules"], "233071": ["Rho GTPase cycle"], "233073": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "233079": ["G alpha (q) signalling events", "Free fatty acid receptors"], "233080": ["G alpha (q) signalling events", "Free fatty acid receptors"], "233081": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "G alpha (q) signalling events", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Free fatty acid receptors"], "233199": ["Striated Muscle Contraction"], "233204": ["TBC/RABGAPs"], "233246": ["Stimuli-sensing channels"], "233274": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "233276": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "233280": ["Miscellaneous transport and binding events"], "233332": ["O-glycosylation of TSR domain-containing proteins"], "233406": ["RHO GTPases activate CIT"], "233489": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "233549": ["Triglyceride biosynthesis"], "233571": ["G alpha (q) signalling events", "P2Y receptors"], "233649": ["VxPx cargo-targeting to cilium"], "233733": ["O-linked glycosylation of mucins"], "233744": ["O-glycosylation of TSR domain-containing proteins"], "233781": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "233799": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine"], "233801": ["Conjugation of salicylate with glycine"], "233805": ["Neddylation"], "233824": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "233826": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "233833": ["Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs"], "233836": ["Inositol transporters"], "233863": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "233875": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "233893": ["Generic Transcription Pathway"], "233900": ["E3 ubiquitin ligases ubiquitinate target proteins"], "233902": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "233904": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "233908": ["mRNA Splicing - Major Pathway"], "233977": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "233979": ["Stimuli-sensing channels"], "234094": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "234129": ["Synthesis of PIPs at the Golgi membrane"], "234130": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "234135": ["PKMTs methylate histone lysines"], "234155": ["Synthesis, secretion, and deacylation of Ghrelin"], "234309": ["Fatty acyl-CoA biosynthesis"], "234356": ["Chondroitin sulfate biosynthesis"], "234366": ["HDACs deacetylate histones", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "234374": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "234407": ["Collagen biosynthesis and modifying enzymes"], "234515": ["Synthesis of PIPs at the early endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "234594": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "234663": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "234664": ["Neddylation"], "234669": ["Phase I - Functionalization of compounds"], "234671": ["Phase I - Functionalization of compounds"], "234673": ["Phase I - Functionalization of compounds"], "234699": ["mRNA decay by 5' to 3' exoribonuclease"], "234700": ["Post-translational modification: synthesis of GPI-anchored proteins"], "234724": ["Phenylalanine and tyrosine catabolism"], "234725": ["Generic Transcription Pathway"], "234729": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "234730": ["GDP-fucose biosynthesis"], "234779": ["GPVI-mediated activation cascade", "Toll Like Receptor 4 (TLR4) Cascade", "Synthesis of IP3 and IP4 in the cytosol", "Role of phospholipids in phagocytosis", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "234847": ["Processing of SMDT1"], "234865": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "234959": ["Generic Transcription Pathway"], "234967": ["Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "235028": ["Generic Transcription Pathway"], "235040": ["Macroautophagy"], "235044": ["Lysosphingolipid and LPA receptors"], "235072": ["MAPK6/MAPK4 signaling"], "235130": ["O-glycosylation of TSR domain-containing proteins"], "235134": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "235281": ["Phase 0 - rapid depolarisation"], "235293": ["Cholesterol biosynthesis via desmosterol"], "235320": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "235323": ["Ub-specific processing proteases"], "235339": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "235386": ["Lysine catabolism"], "235402": ["Axonal growth inhibition (RHOA activation)"], "235416": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "235439": ["Antigen processing: Ubiquitination & Proteasome degradation"], "235441": ["Ub-specific processing proteases"], "235442": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "235497": ["Formation of RNA Pol II elongation complex ", "Formation of the beta-catenin:TCF transactivating complex", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "235504": ["Sialic acid metabolism", "Organic anion transporters"], "235505": ["Platelet degranulation ", "Post-translational modification: synthesis of GPI-anchored proteins"], "235559": ["HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "235567": ["Neutrophil degranulation"], "235574": ["Ion transport by P-type ATPases"], "235582": ["Fructose catabolism"], "235584": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "235606": ["Neutrophil degranulation", "Eukaryotic Translation Termination"], "235610": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Fanconi Anemia Pathway", "G2/M DNA damage checkpoint"], "235611": ["G alpha (12/13) signalling events", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse"], "235612": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "235623": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "235626": ["PKMTs methylate histone lysines"], "235633": ["RAB GEFs exchange GTP for GDP on RABs"], "235636": ["Olfactory Signaling Pathway"], "235661": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "235674": ["alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids", "Neutrophil degranulation", "Peroxisomal protein import"], "235682": ["Generic Transcription Pathway"], "236266": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "236511": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs"], "236539": ["Serine biosynthesis"], "236727": ["Sodium/Proton exchangers"], "236733": ["Ub-specific processing proteases"], "236781": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "236794": ["Sodium/Proton exchangers"], "236899": ["Synthesis of PC"], "236900": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "236915": ["NRAGE signals death through JNK", "Rho GTPase cycle", "GABA A receptor activation"], "236920": ["Rho GTPase cycle"], "236930": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "237038": ["RHO GTPases Activate NADPH Oxidases"], "237178": ["Inactivation, recovery and regulation of the phototransduction cascade"], "237211": ["Fanconi Anemia Pathway"], "237213": ["Neurotransmitter receptors and postsynaptic signal transmission"], "237221": ["snRNP Assembly"], "237222": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "237310": ["Interleukin-20 family signaling"], "237313": ["Interleukin-20 family signaling"], "237320": ["RA biosynthesis pathway"], "237360": ["Collagen biosynthesis and modifying enzymes", "O-glycosylation of TSR domain-containing proteins"], "237362": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "237542": ["Acyl chain remodelling of PS"], "237625": ["Acyl chain remodelling of PG"], "237636": ["Intestinal lipid absorption"], "237754": ["Butyrophilin (BTN) family interactions"], "237758": ["Generic Transcription Pathway"], "237759": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "237775": ["Generic Transcription Pathway"], "237823": ["Purine ribonucleoside monophosphate biosynthesis"], "237831": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "237847": ["Post-translational modification: synthesis of GPI-anchored proteins"], "237868": ["MyD88-independent TLR4 cascade ", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "237911": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "23792": ["LGI-ADAM interactions"], "237928": ["Synthesis of PC", "Synthesis of PE"], "237930": ["Carboxyterminal post-translational modifications of tubulin"], "237934": ["Keratinization", "Formation of the cornified envelope"], "23794": ["Degradation of the extracellular matrix", "O-glycosylation of TSR domain-containing proteins"], "237940": ["Phase I - Functionalization of compounds"], "23796": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "23797": ["PIP3 activates AKT signaling", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "VEGFR2 mediated vascular permeability", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation"], "237979": ["SDK interactions"], "23801": ["Synthesis of 12-eicosatetraenoic acid derivatives"], "238011": ["Glycosphingolipid metabolism"], "23802": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "ER Quality Control Compartment (ERQC)"], "238024": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "238055": ["Cell surface interactions at the vascular wall", "Scavenging by Class B Receptors", "Scavenging by Class A Receptors", "Scavenging by Class H Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Platelet sensitization by LDL", "Regulation of TLR by endogenous ligand", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDL assembly", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Chylomicron clearance", "LDL clearance", "VLDL clearance", "Retinoid metabolism and transport"], "23806": ["ISG15 antiviral mechanism"], "23807": ["Antigen processing: Ubiquitination & Proteasome degradation"], "238076": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "23808": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "238123": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "238130": ["Factors involved in megakaryocyte development and platelet production"], "238247": ["HDACs deacetylate histones"], "23827": ["Cytosolic sulfonation of small molecules"], "238271": ["Voltage gated Potassium channels"], "238276": ["Trafficking of AMPA receptors", "ROBO receptors bind AKAP5"], "23830": ["Degradation of the extracellular matrix"], "23831": ["Reversible hydration of carbon dioxide"], "23832": ["Chemokine receptors bind chemokines", "G alpha (q) signalling events"], "23834": ["Activation of ATR in response to replication stress", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "CDK-mediated phosphorylation and removal of Cdc6"], "238377": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "238384": ["Sodium/Calcium exchangers"], "238393": ["Platelet degranulation ", "Neutrophil degranulation"], "238395": ["Platelet degranulation ", "Neutrophil degranulation"], "23844": ["Stimuli-sensing channels"], "23845": ["DAP12 interactions", "Neutrophil degranulation"], "238463": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "23850": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "238505": ["Methylation", "Sulfur amino acid metabolism", "Cobalamin (Cbl, vitamin B12) transport and metabolism"], "238555": ["Butyrophilin (BTN) family interactions"], "238568": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "23859": ["Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade", "Neurexins and neuroligins"], "23871": ["Oncogene Induced Senescence"], "23872": ["Oncogene Induced Senescence"], "238725": ["G alpha (s) signalling events"], "23876": ["Elastic fibre formation", "Molecules associated with elastic fibres"], "238799": ["Intraflagellar transport"], "23880": ["Generation of second messenger molecules", "Signal regulatory protein family interactions"], "238831": ["mRNA Splicing - Major Pathway"], "23887": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "238871": ["DARPP-32 events", "G alpha (s) signalling events"], "23888": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Retinoid metabolism and transport"], "23893": ["Signaling by BMP"], "23894": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "23900": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "239027": ["Rho GTPase cycle"], "23908": ["HS-GAG biosynthesis"], "239096": ["Adherens junctions interactions"], "23912": ["Rho GTPase cycle", "Neutrophil degranulation"], "23917": ["Neutrophil degranulation", "Purine ribonucleoside monophosphate biosynthesis"], "23918": ["Neutrophil degranulation", "Purine ribonucleoside monophosphate biosynthesis"], "23919": ["G alpha (i) signalling events", "Relaxin receptors"], "23921": ["Regulation of KIT signaling", "Factors involved in megakaryocyte development and platelet production"], "23923": ["Lysine catabolism", "Tryptophan catabolism"], "23925": ["Peptide ligand-binding receptors"], "239250": ["Receptor-type tyrosine-protein phosphatases"], "239273": ["Platelet degranulation ", "ABC-family proteins mediated transport"], "23928": ["Laminin interactions", "MET activates PTK2 signaling"], "239283": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "239336": ["G alpha (i) signalling events", "Relaxin receptors"], "239337": ["O-glycosylation of TSR domain-containing proteins"], "23934": ["Post-translational modification: synthesis of GPI-anchored proteins"], "23939": ["ERK/MAPK targets", "Signalling to ERK5", "ERKs are inactivated", "Senescence-Associated Secretory Phenotype (SASP)", "Gastrin-CREB signalling pathway via PKC and MAPK", "RET signaling"], "239393": ["Retinoid metabolism and transport"], "239405": ["Regulation of FZD by ubiquitination"], "23942": ["HDACs deacetylate histones", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "23943": ["Glycosphingolipid metabolism"], "239436": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "239447": ["Lectin pathway of complement activation", "Initial triggering of complement"], "23945": ["Acyl chain remodeling of DAG and TAG", "Arachidonate production from DAG"], "23948": ["Activation of Matrix Metalloproteinases"], "23950": ["Regulation of HSF1-mediated heat shock response"], "239528": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs"], "239530": ["G alpha (s) signalling events"], "239546": ["Generic Transcription Pathway"], "239552": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "23956": ["Glycosphingolipid metabolism"], "23957": ["Nuclear Receptor transcription pathway"], "23958": ["Nuclear Receptor transcription pathway"], "23959": ["Purine catabolism"], "239591": ["Carboxyterminal post-translational modifications of tubulin"], "239606": ["Inositol transporters"], "239652": ["Generic Transcription Pathway"], "23969": ["Clathrin-mediated endocytosis"], "23970": ["Clathrin-mediated endocytosis"], "239706": ["Protein methylation"], "23971": ["Transport and synthesis of PAPS"], "23972": ["Transport and synthesis of PAPS"], "239759": ["Synthesis of PA"], "23980": ["MAP2K and MAPK activation", "Negative regulation of MAPK pathway"], "239827": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "23983": ["mRNA Splicing - Major Pathway"], "23984": ["cGMP effects", "G alpha (s) signalling events"], "239849": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "23985": ["Multifunctional anion exchangers"], "239857": ["Adherens junctions interactions"], "23986": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "23988": ["RHO GTPases Activate NADPH Oxidases", "Regulation of TP53 Activity through Phosphorylation", "PI5P Regulates TP53 Acetylation", "Negative regulators of DDX58/IFIH1 signaling"], "23989": ["Generic Transcription Pathway"], "23992": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "23993": ["Degradation of the extracellular matrix"], "239932": ["Keratinization"], "239933": ["Keratinization"], "23996": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "23997": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "239985": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "24001": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "240028": ["Endosomal/Vacuolar pathway", "Antigen processing: Ubiquitination & Proteasome degradation"], "240047": ["Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "240057": ["Regulation of RAS by GAPs"], "240069": ["Fatty acyl-CoA biosynthesis"], "240087": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "240095": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "240119": ["Sialic acid metabolism"], "24012": ["G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "24013": ["Inactivation, recovery and regulation of the phototransduction cascade"], "24014": ["OAS antiviral response", "Interferon alpha/beta signaling"], "24015": ["OAS antiviral response", "Interferon alpha/beta signaling"], "240168": ["Activation of RAS in B cells", "RAF/MAP kinase cascade"], "24018": ["mRNA Capping", "RNA Pol II CTD phosphorylation and interaction with CE"], "240215": ["Bicarbonate transporters"], "240263": ["Neddylation"], "24030": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "240322": ["O-glycosylation of TSR domain-containing proteins"], "240332": ["Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism"], "240334": ["Platelet degranulation "], "240354": ["Activation of NF-kappaB in B cells", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "CLEC7A/inflammasome pathway"], "240396": ["Antigen processing: Ubiquitination & Proteasome degradation"], "240444": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "24046": ["Phase 0 - rapid depolarisation"], "24047": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "240518": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "24059": ["Transport of organic anions"], "240595": ["Voltage gated Potassium channels"], "24060": ["Sialic acid metabolism", "Transport of nucleotide sugars"], "24061": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins"], "24063": ["EGFR downregulation"], "240633": ["Formation of the cornified envelope"], "24064": ["Spry regulation of FGF signaling", "EGFR downregulation"], "240641": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "240672": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "24069": ["Degradation of GLI1 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state"], "24070": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "24074": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "24075": ["Ub-specific processing proteases", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "240752": ["Synthesis of PIPs at the plasma membrane"], "240753": ["Synthesis of PIPs at the plasma membrane"], "240756": ["Degradation of DVL"], "240816": ["G alpha (q) signalling events"], "24087": ["Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation"], "240873": ["TNFs bind their physiological receptors"], "24088": ["Beta defensins", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation"], "240888": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "240913": ["Degradation of the extracellular matrix", "O-glycosylation of TSR domain-containing proteins"], "24099": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "24105": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Antigen processing: Ubiquitination & Proteasome degradation"], "241062": ["Attachment of GPI anchor to uPAR"], "24108": ["Neddylation"], "24110": ["ISG15 antiviral mechanism", "Ub-specific processing proteases", "Regulation of IFNA signaling"], "24111": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "241113": ["Macroautophagy", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "241118": ["Stimuli-sensing channels"], "24115": ["Stimuli-sensing channels"], "241159": ["Glycosphingolipid metabolism", "Sialic acid metabolism"], "24116": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "241196": ["RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "241197": ["Neutrophil degranulation"], "241201": ["Adherens junctions interactions"], "241226": ["Molecules associated with elastic fibres", "Integrin cell surface interactions", "ECM proteoglycans"], "241230": ["Sialic acid metabolism", "N-Glycan antennae elongation"], "24127": ["Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "241275": ["RHO GTPases Activate NADPH Oxidases"], "24128": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "241296": ["Miscellaneous transport and binding events"], "241391": ["O-linked glycosylation of mucins"], "241447": ["Sphingolipid de novo biosynthesis"], "241452": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "241489": ["cGMP effects", "G alpha (s) signalling events"], "241593": ["RHO GTPases Activate NADPH Oxidases", "Regulation of TP53 Activity through Phosphorylation", "PI5P Regulates TP53 Acetylation", "Negative regulators of DDX58/IFIH1 signaling"], "241612": ["Multifunctional anion exchangers"], "241633": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "241764": ["Regulation of TP53 Activity through Methylation"], "241769": ["Phase 4 - resting membrane potential"], "241794": ["Voltage gated Potassium channels"], "241915": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "241944": ["Generic Transcription Pathway"], "242083": ["Sphingolipid de novo biosynthesis"], "242093": ["G alpha (i) signalling events", "Relaxin receptors"], "242100": ["Antimicrobial peptides"], "242109": ["Generic Transcription Pathway"], "242126": ["Organic cation transport"], "242151": ["Voltage gated Potassium channels"], "242202": ["cGMP effects"], "242259": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "242274": ["Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade", "Neutrophil degranulation"], "242285": ["RA biosynthesis pathway"], "242291": ["Cytosolic sulfonation of small molecules"], "242341": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "242362": ["N-glycan trimming and elongation in the cis-Golgi"], "242406": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network", "RAB GEFs exchange GTP for GDP on RABs"], "242418": ["Neddylation"], "242425": ["Activation of G protein gated Potassium channels", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "GABA B receptor activation", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "242517": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "242519": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "242521": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "242546": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "242557": ["Macroautophagy"], "242585": ["Formation of the active cofactor, UDP-glucuronate", "Transport of nucleotide sugars"], "242607": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "242667": ["Neurexins and neuroligins"], "242669": ["Agmatine biosynthesis"], "242681": ["RAB geranylgeranylation"], "242687": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "242700": ["Interleukin-20 family signaling"], "242705": ["CDC6 association with the ORC:origin complex", "Cyclin D associated events in G1"], "242726": ["Chromatin modifying enzymes"], "242785": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "242851": ["PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "G-protein activation", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "242960": ["Neddylation", "Iron uptake and transport", "Antigen processing: Ubiquitination & Proteasome degradation"], "243078": ["Synthesis of very long-chain fatty acyl-CoAs"], "243085": ["Glucuronidation"], "243168": ["Lipid particle organization"], "243270": ["Hydroxycarboxylic acid-binding receptors", "G alpha (i) signalling events"], "243328": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "243362": ["Rho GTPase cycle"], "243372": ["Generic Transcription Pathway"], "243376": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "243377": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "243382": ["Branched-chain amino acid catabolism"], "243407": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "243499": ["Neurexins and neuroligins"], "243537": ["Histidine catabolism"], "243547": ["Trafficking of GluR2-containing AMPA receptors"], "243574": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "243616": ["Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism", "Reuptake of GABA"], "243634": ["Stimuli-sensing channels"], "243743": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "243755": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "243764": ["Muscarinic acetylcholine receptors", "G alpha (i) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "243816": ["GPVI-mediated activation cascade", "Cell surface interactions at the vascular wall", "Platelet Adhesion to exposed collagen"], "243819": ["COPII-mediated vesicle transport"], "243834": ["Generic Transcription Pathway"], "243864": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "243880": ["Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "243881": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "243906": ["Generic Transcription Pathway"], "243911": ["Nephrin family interactions"], "243914": ["LGI-ADAM interactions"], "243923": ["Inactivation, recovery and regulation of the phototransduction cascade"], "243958": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "243961": ["Neurexins and neuroligins"], "243963": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Generic Transcription Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "244187": ["Olfactory Signaling Pathway"], "244209": ["Vitamin D (calciferol) metabolism", "Vitamins"], "244216": ["Generic Transcription Pathway"], "244219": ["Generic Transcription Pathway"], "244310": ["Neurexins and neuroligins"], "244329": ["Condensation of Prophase Chromosomes"], "244332": ["Beta defensins", "Defensins"], "244349": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "244373": ["ABC-family proteins mediated transport"], "244421": ["Antigen processing: Ubiquitination & Proteasome degradation"], "244495": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "244556": ["Generic Transcription Pathway"], "244585": ["Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane"], "244650": ["Negative regulation of the PI3K/AKT network"], "244666": ["Translesion Synthesis by POLH"], "244682": ["Post-translational modification: synthesis of GPI-anchored proteins"], "244694": ["HDMs demethylate histones"], "244713": ["Generic Transcription Pathway"], "244867": ["Rho GTPase cycle"], "244882": ["PI Metabolism"], "245000": ["Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Fanconi Anemia Pathway", "G2/M DNA damage checkpoint"], "245026": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "245126": ["Neutrophil degranulation"], "245282": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "245446": ["Receptor-type tyrosine-protein phosphatases"], "245450": ["Receptor-type tyrosine-protein phosphatases"], "245474": ["Telomere Extension By Telomerase"], "245527": ["TNFs bind their physiological receptors"], "245532": ["Acyl chain remodeling of DAG and TAG", "The retinoid cycle in cones (daylight vision)", "Wax biosynthesis"], "245533": ["Arachidonic acid metabolism", "Wax biosynthesis"], "245537": ["Neurexins and neuroligins"], "245595": ["Generic Transcription Pathway"], "245615": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "245616": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "245638": ["Golgi Associated Vesicle Biogenesis"], "245643": ["Neutrophil degranulation"], "245650": ["Inactivation, recovery and regulation of the phototransduction cascade"], "245670": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "245684": ["MAP2K and MAPK activation"], "245688": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HATs acetylate histones", "RMTs methylate histone arginines", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Neddylation", "Transcriptional Regulation by E2F6"], "245828": ["COPII-mediated vesicle transport", "Neutrophil degranulation", "RAB GEFs exchange GTP for GDP on RABs"], "245839": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "245841": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "245847": ["Synthesis of UDP-N-acetyl-glucosamine"], "245860": ["Macroautophagy"], "245866": ["Hedgehog 'off' state", "Intraflagellar transport"], "245880": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "245886": ["RAB GEFs exchange GTP for GDP on RABs"], "245944": ["Retrograde transport at the Trans-Golgi-Network"], "246049": ["Amino acid transport across the plasma membrane", "Proton-coupled neutral amino acid transporters"], "246082": ["Beta defensins", "Defensins"], "246083": ["Beta defensins", "Defensins"], "246084": ["Beta defensins", "Defensins"], "246103": ["Ub-specific processing proteases"], "246133": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "246190": ["Post-translational modification: synthesis of GPI-anchored proteins"], "246221": ["Degradation of cysteine and homocysteine"], "246228": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "246256": ["Post-translational modification: synthesis of GPI-anchored proteins", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "246278": ["Cross-presentation of soluble exogenous antigens (endosomes)"], "246313": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "246316": ["LGI-ADAM interactions"], "246691": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "246703": ["Nicotinamide salvaging"], "246707": ["Molecules associated with elastic fibres"], "246709": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "246710": ["Rho GTPase cycle"], "246746": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "246779": ["Interleukin-27 signaling"], "246787": ["Cellular hexose transport"], "246788": ["TRP channels"], "252837": ["Chemokine receptors bind chemokines"], "252870": ["Ub-specific processing proteases", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Degradation", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "252903": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "252972": ["Stimuli-sensing channels"], "257630": ["Interleukin-17 signaling"], "257633": ["Synthesis of very long-chain fatty acyl-CoAs"], "257635": ["Threonine catabolism"], "257665": ["Olfactory Signaling Pathway"], "257734": ["Olfactory Signaling Pathway"], "257872": ["Olfactory Signaling Pathway"], "257875": ["Olfactory Signaling Pathway"], "257880": ["Olfactory Signaling Pathway"], "257883": ["Olfactory Signaling Pathway"], "257898": ["Olfactory Signaling Pathway"], "257902": ["Olfactory Signaling Pathway"], "257904": ["Olfactory Signaling Pathway"], "257905": ["Olfactory Signaling Pathway"], "257906": ["Olfactory Signaling Pathway"], "257909": ["Olfactory Signaling Pathway"], "257910": ["Olfactory Signaling Pathway"], "257915": ["Olfactory Signaling Pathway"], "257916": ["Olfactory Signaling Pathway"], "257917": ["Olfactory Signaling Pathway"], "257921": ["Olfactory Signaling Pathway"], "257929": ["Olfactory Signaling Pathway"], "257931": ["Olfactory Signaling Pathway"], "257933": ["Olfactory Signaling Pathway"], "257936": ["Olfactory Signaling Pathway"], "257958": ["Olfactory Signaling Pathway"], "257962": ["Olfactory Signaling Pathway"], "257972": ["Olfactory Signaling Pathway"], "257974": ["Olfactory Signaling Pathway"], "257984": ["Olfactory Signaling Pathway"], "257985": ["Olfactory Signaling Pathway"], "258008": ["Olfactory Signaling Pathway"], "258016": ["Olfactory Signaling Pathway"], "258025": ["Olfactory Signaling Pathway"], "258035": ["Olfactory Signaling Pathway"], "258036": ["Olfactory Signaling Pathway"], "258039": ["Olfactory Signaling Pathway"], "258041": ["Olfactory Signaling Pathway"], "258042": ["Olfactory Signaling Pathway"], "258051": ["Olfactory Signaling Pathway"], "258064": ["Olfactory Signaling Pathway"], "258068": ["Olfactory Signaling Pathway"], "258074": ["Olfactory Signaling Pathway"], "258075": ["Olfactory 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["Olfactory Signaling Pathway"], "258720": ["Olfactory Signaling Pathway"], "258721": ["Olfactory Signaling Pathway"], "258727": ["Olfactory Signaling Pathway"], "258728": ["Olfactory Signaling Pathway"], "258729": ["Olfactory Signaling Pathway"], "258730": ["Olfactory Signaling Pathway"], "258732": ["Olfactory Signaling Pathway"], "258733": ["Olfactory Signaling Pathway"], "258734": ["Olfactory Signaling Pathway"], "258736": ["Olfactory Signaling Pathway"], "258738": ["Olfactory Signaling Pathway"], "258741": ["Olfactory Signaling Pathway"], "258742": ["Olfactory Signaling Pathway"], "258744": ["Olfactory Signaling Pathway"], "258745": ["Olfactory Signaling Pathway"], "258746": ["Olfactory Signaling Pathway"], "258748": ["Olfactory Signaling Pathway"], "258749": ["Olfactory Signaling Pathway"], "258752": ["Olfactory Signaling Pathway"], "258753": ["Olfactory Signaling Pathway"], "258756": ["Olfactory Signaling Pathway"], "258757": ["Olfactory Signaling Pathway"], "258763": ["Olfactory 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"258883": ["Olfactory Signaling Pathway"], "258893": ["Olfactory Signaling Pathway"], "258894": ["Olfactory Signaling Pathway"], "258895": ["Olfactory Signaling Pathway"], "258896": ["Olfactory Signaling Pathway"], "258897": ["Olfactory Signaling Pathway"], "258898": ["Olfactory Signaling Pathway"], "258899": ["Olfactory Signaling Pathway"], "258900": ["Olfactory Signaling Pathway"], "258901": ["Olfactory Signaling Pathway"], "258902": ["Olfactory Signaling Pathway"], "258903": ["Olfactory Signaling Pathway"], "258904": ["Olfactory Signaling Pathway"], "258912": ["Olfactory Signaling Pathway"], "258913": ["Olfactory Signaling Pathway"], "258914": ["Olfactory Signaling Pathway"], "258922": ["Olfactory Signaling Pathway"], "258923": ["Olfactory Signaling Pathway"], "258924": ["Olfactory Signaling Pathway"], "258925": ["Olfactory Signaling Pathway"], "258930": ["Olfactory Signaling Pathway"], "258932": ["Olfactory Signaling Pathway"], "258933": ["Olfactory Signaling Pathway"], "258934": ["Olfactory Signaling Pathway"], "258935": ["Olfactory Signaling Pathway"], "258937": ["Olfactory Signaling Pathway"], "258939": ["Olfactory Signaling Pathway"], "258941": ["Olfactory Signaling Pathway"], "258943": ["Olfactory Signaling Pathway"], "258944": ["Olfactory Signaling Pathway"], "258954": ["Olfactory Signaling Pathway"], "258959": ["Olfactory Signaling Pathway"], "258960": ["Olfactory Signaling Pathway"], "258961": ["Olfactory Signaling Pathway"], "258967": ["Olfactory Signaling Pathway"], "258968": ["Olfactory Signaling Pathway"], "258969": ["Olfactory Signaling Pathway"], "258970": ["Olfactory Signaling Pathway"], "258971": ["Olfactory Signaling Pathway"], "258973": ["Olfactory Signaling Pathway"], "258975": ["Olfactory Signaling Pathway"], "258977": ["Olfactory Signaling Pathway"], "258979": ["Olfactory Signaling Pathway"], "258980": ["Olfactory Signaling Pathway"], "258982": ["Olfactory Signaling Pathway"], "258983": ["Olfactory Signaling Pathway"], "258985": ["Olfactory Signaling Pathway"], "258987": ["Olfactory Signaling Pathway"], "258988": ["Olfactory Signaling Pathway"], "258990": ["Olfactory Signaling Pathway"], "258991": ["Olfactory Signaling Pathway"], "258992": ["Olfactory Signaling Pathway"], "258996": ["Olfactory Signaling Pathway"], "258997": ["Olfactory Signaling Pathway"], "258998": ["Olfactory Signaling Pathway"], "258999": ["Olfactory Signaling Pathway"], "259000": ["Olfactory Signaling Pathway"], "259001": ["Olfactory Signaling Pathway"], "259002": ["Olfactory Signaling Pathway"], "259003": ["Olfactory Signaling Pathway"], "259004": ["Olfactory Signaling Pathway"], "259007": ["Olfactory Signaling Pathway"], "259008": ["Olfactory Signaling Pathway"], "259009": ["Olfactory Signaling Pathway"], "259010": ["Olfactory Signaling Pathway"], "259011": ["Olfactory Signaling Pathway"], "259012": ["Olfactory Signaling Pathway"], "259014": ["Olfactory Signaling Pathway"], "259016": ["Olfactory Signaling Pathway"], "259017": ["Olfactory Signaling Pathway"], "259018": ["Olfactory Signaling Pathway"], "259019": ["Olfactory Signaling Pathway"], "259021": ["Olfactory Signaling Pathway"], "259022": ["Olfactory Signaling Pathway"], "259025": ["Olfactory Signaling Pathway"], "259026": ["Olfactory Signaling Pathway"], "259033": ["Olfactory Signaling Pathway"], "259034": ["Olfactory Signaling Pathway"], "259035": ["Olfactory Signaling Pathway"], "259036": ["Olfactory Signaling Pathway"], "259040": ["Olfactory Signaling Pathway"], "259041": ["Olfactory Signaling Pathway"], "259042": ["Olfactory Signaling Pathway"], "259044": ["Olfactory Signaling Pathway"], "259045": ["Olfactory Signaling Pathway"], "259046": ["Olfactory Signaling Pathway"], "259047": ["Olfactory Signaling Pathway"], "259052": ["Olfactory Signaling Pathway"], "259053": ["Olfactory Signaling Pathway"], "259054": ["Olfactory Signaling Pathway"], "259055": ["Olfactory Signaling Pathway"], "259056": ["Olfactory Signaling Pathway"], "259058": ["Olfactory Signaling Pathway"], "259061": ["Olfactory Signaling Pathway"], "259062": ["Olfactory Signaling Pathway"], "259063": ["Olfactory Signaling Pathway"], "259067": ["Olfactory Signaling Pathway"], "259069": ["Olfactory Signaling Pathway"], "259070": ["Olfactory Signaling Pathway"], "259071": ["Olfactory Signaling Pathway"], "259074": ["Olfactory Signaling Pathway"], "259075": ["Olfactory Signaling Pathway"], "259089": ["Olfactory Signaling Pathway"], "259091": ["Olfactory Signaling Pathway"], "259092": ["Olfactory Signaling Pathway"], "259095": ["Olfactory Signaling Pathway"], "259097": ["Olfactory Signaling Pathway"], "259100": ["Olfactory Signaling Pathway"], "259106": ["Olfactory Signaling Pathway"], "259109": ["Olfactory Signaling Pathway"], "259110": ["Olfactory Signaling Pathway"], "259112": ["Olfactory Signaling Pathway"], "259113": ["Olfactory Signaling Pathway"], "259119": ["Olfactory Signaling Pathway"], "259122": ["Olfactory Signaling Pathway"], "259124": ["Olfactory Signaling Pathway"], "259126": ["Olfactory Signaling Pathway"], "259145": ["Olfactory Signaling Pathway"], "259147": ["Olfactory Signaling Pathway"], "259148": ["Olfactory Signaling Pathway"], "259161": ["Olfactory Signaling Pathway"], "259163": ["Olfactory Signaling Pathway"], "259165": ["Olfactory Signaling Pathway"], "259277": ["Formation of the cornified envelope"], "259279": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "259300": ["Factors involved in megakaryocyte development and platelet production"], "259301": ["Antimicrobial peptides"], "259302": ["Rho GTPase cycle"], "260302": ["MET receptor recycling"], "260305": ["Signaling by Hippo", "Anchoring of the basal body to the plasma membrane"], "260409": ["MAPK6/MAPK4 signaling"], "260423": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "26357": ["Iron uptake and transport"], "26358": ["RA biosynthesis pathway", "Ethanol oxidation"], "26361": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "26362": ["VEGFA-VEGFR2 Pathway"], "26363": ["Biotin transport and metabolism"], "26364": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation"], "26365": ["Fibronectin matrix formation", "Post-translational modification: synthesis of GPI-anchored proteins", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "26366": ["Fibronectin matrix formation", "Post-translational modification: synthesis of GPI-anchored proteins", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "26367": ["Fibronectin matrix formation", "Post-translational modification: synthesis of GPI-anchored proteins", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "26370": ["Regulation of PLK1 Activity at G2/M Transition", "SUMOylation of DNA damage response and repair proteins", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "AURKA Activation by TPX2"], "26372": ["Stimuli-sensing channels"], "26373": ["Stimuli-sensing channels"], "26374": ["Autodegradation of the E3 ubiquitin ligase COP1", "Neddylation"], "26377": ["Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "26378": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "26379": ["Nuclear Receptor transcription pathway"], "26380": ["Nuclear Receptor transcription pathway"], "263803": ["RHO GTPases activate PKNs"], "26381": ["Nuclear Receptor transcription pathway"], "26382": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "26383": ["Reversal of alkylation damage by DNA dioxygenases"], "26384": ["Glycolysis"], "26385": ["G alpha (s) signalling events"], "26394": ["L1CAM interactions"], "26395": ["MAPK3 (ERK1) activation", "Signal transduction by L1", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway"], "26396": ["MAPK1 (ERK2) activation", "Signal transduction by L1", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway"], "26397": ["Oxidative Stress Induced Senescence", "activated TAK1 mediates p38 MAPK activation"], "26398": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1"], "26399": ["NOD1/2 Signaling Pathway", "Oxidative Stress Induced Senescence", "activated TAK1 mediates p38 MAPK activation", "PI5P Regulates TP53 Acetylation", "Interleukin-1 signaling"], "26400": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1"], "26401": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "FCERI mediated MAPK activation", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 cascade initiated on plasma membrane"], "26403": ["RAF activation"], "26406": ["Interleukin-1 signaling"], "264064": ["Generic Transcription Pathway", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "26408": ["Oxidative Stress Induced Senescence"], "26409": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "Ca2+ pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "26410": ["CD28 dependent PI3K/Akt signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "26413": ["phospho-PLA2 pathway", "RAF-independent MAPK1/3 activation", "MAPK1 (ERK2) activation", "Spry regulation of FGF signaling", "Golgi Cisternae Pericentriolar Stack Reorganization", "Frs2-mediated activation", "ERK/MAPK targets", "ERKs are inactivated", "Regulation of actin dynamics for phagocytic cup formation", "Senescence-Associated Secretory Phenotype (SASP)", "NCAM signaling for neurite out-growth", "Recycling pathway of L1", "Signal transduction by L1", "Activation of the AP-1 family of transcription factors", "Thrombin signalling through proteinase activated receptors (PARs)", "Negative regulation of FGFR1 signaling", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signal attenuation", "Gastrin-CREB signalling pathway via PKC and MAPK", "Growth hormone receptor signaling"], "264134": ["Intraflagellar transport"], "26414": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors"], "26415": ["NOD1/2 Signaling Pathway", "DSCAM interactions", "VEGFA-VEGFR2 Pathway"], "26416": ["NOD1/2 Signaling Pathway", "p38MAPK events", "ERK/MAPK targets", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "DSCAM interactions", "ADP signalling through P2Y purinoceptor 1", "Platelet sensitization by LDL", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Activation of the AP-1 family of transcription factors", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation", "Regulation of TP53 Activity through Phosphorylation"], "26417": ["MAPK3 (ERK1) activation", "RAF-independent MAPK1/3 activation", "ISG15 antiviral mechanism", "Spry regulation of FGF signaling", "Golgi Cisternae Pericentriolar Stack Reorganization", "Frs2-mediated activation", "ERK/MAPK targets", "ERKs are inactivated", "Regulation of actin dynamics for phagocytic cup formation", "Senescence-Associated Secretory Phenotype (SASP)", "NCAM signaling for neurite out-growth", "Signal transduction by L1", "Activation of the AP-1 family of transcription factors", "Thrombin signalling through proteinase activated receptors (PARs)", "Negative regulation of FGFR1 signaling", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RNA Polymerase I Promoter Opening", "Signal attenuation", "Gastrin-CREB signalling pathway via PKC and MAPK", "Growth hormone receptor signaling"], "26419": ["Activation of BMF and translocation to mitochondria", "NRAGE signals death through JNK", "Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "DSCAM interactions", "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Interleukin-38 signaling"], "26420": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors"], "26423": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "26424": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Estrogen-dependent gene expression"], "26428": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "26429": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "26432": ["Collagen biosynthesis and modifying enzymes"], "26433": ["Collagen biosynthesis and modifying enzymes"], "26434": ["Post-translational modification: synthesis of GPI-anchored proteins"], "26440": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "26441": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "26442": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "26443": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "26444": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "26445": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "26446": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "26447": ["Translesion synthesis by POLI", "Termination of translesion DNA synthesis"], "26457": ["Transport of fatty acids"], "26458": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Alpha-oxidation of phytanate", "Neutrophil degranulation", "Peroxisomal protein import"], "26459": ["Recycling of bile acids and salts"], "26464": ["Post-translational modification: synthesis of GPI-anchored proteins"], "264895": ["Mitochondrial Fatty Acid Beta-Oxidation"], "26554": ["Degradation of DVL", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26556": ["Neurexins and neuroligins"], "26557": ["Neurexins and neuroligins"], "26558": ["Neurexins and neuroligins"], "26560": ["Keratinization"], "26563": ["WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "26565": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "26569": ["Transport of fatty acids"], "26570": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "26572": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "266620": ["Beta defensins", "Defensins"], "266632": ["PIP3 activates AKT signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "266690": ["Erythrocytes take up carbon dioxide and release oxygen"], "266692": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "266815": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "267019": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "26754": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "26757": ["CRMPs in Sema3A signaling"], "268281": ["E3 ubiquitin ligases ubiquitinate target proteins"], "268291": ["Antigen processing: Ubiquitination & Proteasome degradation"], "268345": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "268379": ["Neutrophil degranulation"], "268395": ["Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1"], "268417": ["Generic Transcription Pathway"], "268420": ["Reversal of alkylation damage by DNA dioxygenases"], "268465": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "268470": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "268482": ["Keratinization", "Formation of the cornified envelope"], "268512": ["Multifunctional anion exchangers"], "268527": ["Estrogen-dependent gene expression"], "268566": ["Molybdenum cofactor biosynthesis"], "268591": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation"], "268656": ["Sphingolipid de novo biosynthesis"], "268697": ["APC/C:Cdc20 mediated degradation of Cyclin B", "Phosphorylation of Emi1", "Resolution of Sister Chromatid Cohesion", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "268706": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "268739": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "26874": ["ABC transporters in lipid homeostasis"], "268749": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "26876": ["RA biosynthesis pathway", "Ethanol oxidation"], "268782": ["Glyoxylate metabolism and glycine degradation"], "268783": ["Synthesis of PIPs at the early endosome membrane"], "26879": ["Glycosphingolipid metabolism"], "26886": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "268860": ["Degradation of GABA"], "26887": ["O-linked glycosylation of mucins"], "268878": ["Ion transport by P-type ATPases"], "268885": ["Formation of the cornified envelope"], "268890": ["Post-translational modification: synthesis of GPI-anchored proteins"], "268902": ["Signaling by ROBO receptors", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "268903": ["SUMOylation of transcription cofactors", "Estrogen-dependent gene expression"], "268905": ["Keratinization"], "26891": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "26893": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "268930": ["Polo-like kinase mediated events", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint"], "268934": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "268935": ["Degradation of the extracellular matrix"], "268936": ["Platelet degranulation ", "HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "26894": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "26895": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "268958": ["Degradation of the extracellular matrix"], "26896": ["Generic Transcription Pathway"], "26897": ["Mitochondrial Fatty Acid Beta-Oxidation", "Peroxisomal protein import"], "268970": ["Rho GTPase cycle"], "268977": ["Molecules associated with elastic fibres", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "26898": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "26903": ["Smooth Muscle Contraction"], "26904": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "26905": ["L13a-mediated translational silencing of Ceruloplasmin expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "Recycling of eIF2:GDP"], "269060": ["Arachidonate production from DAG"], "269061": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "26909": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "269113": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "269116": ["Neurofascin interactions", "Neutrophil degranulation"], "269120": ["Degradation of the extracellular matrix"], "269132": ["Collagen biosynthesis and modifying enzymes"], "269152": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "269180": ["Synthesis of PIPs at the early endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "269181": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "N-Glycan antennae elongation"], "26920": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "26921": ["Oxidative Stress Induced Senescence"], "26922": ["Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "269252": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "26927": ["SUMOylation of transcription factors"], "269275": ["Signaling by Activin"], "269295": ["Post-translational modification: synthesis of GPI-anchored proteins"], "26931": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "26932": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins", "RAF activation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "269328": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "26934": ["Rho GTPase cycle", "MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "269344": ["RNA polymerase II transcribes snRNA genes"], "269346": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "269378": ["Methylation", "Sulfur amino acid metabolism"], "26938": ["Sialic acid metabolism"], "26939": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "26940": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Complex I biogenesis", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 cascade initiated on plasma membrane"], "269400": ["Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"], "269424": ["HATs acetylate histones"], "26943": ["Serine biosynthesis"], "269437": ["Synthesis of IP3 and IP4 in the cytosol"], "26946": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels"], "269470": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "26949": ["Neutrophil degranulation"], "26951": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "269514": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "269523": ["Translesion Synthesis by POLH", "HSF1 activation", "ABC-family proteins mediated transport", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Hedgehog ligand biogenesis", "Josephin domain DUBs", "Ovarian tumor domain proteases", "Neutrophil degranulation", "Protein methylation"], "269529": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "269536": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "269582": ["Apoptotic cleavage of cellular proteins", "Activation of ATR in response to replication stress", "Ub-specific processing proteases", "Processing of DNA double-strand break ends"], "269587": ["Neurexins and neuroligins"], "269589": ["TBC/RABGAPs"], "269608": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "269614": ["Coenzyme A biosynthesis"], "269615": ["Synthesis of IP3 and IP4 in the cytosol"], "269642": ["Amino acid synthesis and interconversion (transamination)"], "26965": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Iron uptake and transport", "Antigen processing: Ubiquitination & Proteasome degradation"], "26968": ["Platelet degranulation "], "26970": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "269704": ["Generic Transcription Pathway"], "26971": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG", "Synthesis of PA"], "269774": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "269784": ["Post-translational modification: synthesis of GPI-anchored proteins"], "269823": ["Synthesis of 5-eicosatetraenoic acids"], "26987": ["ISG15 antiviral mechanism"], "269870": ["Generic Transcription Pathway"], "26992": ["Regulation of TP53 Activity through Acetylation"], "269941": ["Chondroitin sulfate biosynthesis"], "269951": ["Transcriptional activation of mitochondrial biogenesis", "Citric acid cycle (TCA cycle)"], "269954": ["Carboxyterminal post-translational modifications of tubulin"], "269959": ["O-glycosylation of TSR domain-containing proteins"], "269966": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "269997": ["Generic Transcription Pathway"], "270049": ["O-linked glycosylation of mucins"], "27007": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 signaling"], "270076": ["Lysine catabolism"], "270084": ["Acyl chain remodelling of PC"], "270096": ["RAB GEFs exchange GTP for GDP on RABs"], "270118": ["NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling"], "27015": ["Translesion synthesis by POLK", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "270151": ["Negative regulators of DDX58/IFIH1 signaling"], "270160": ["Intra-Golgi traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "270163": ["Rho GTPase cycle"], "270190": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "270192": ["COPI-independent Golgi-to-ER retrograde traffic", "Retrograde transport at the Trans-Golgi-Network", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "270198": ["Glycolysis"], "27029": ["HS-GAG degradation"], "27047": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "27050": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "27053": ["Amino acid synthesis and interconversion (transamination)"], "27059": ["Golgi Associated Vesicle Biogenesis"], "27060": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "27061": ["Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "270627": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "270669": ["ATF6 (ATF6-alpha) activates chaperones"], "270685": ["Metabolism of folate and pterines"], "27078": ["Anchoring of the basal body to the plasma membrane"], "27096": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "271036": ["Sperm Motility And Taxes"], "271047": ["Platelet degranulation ", "Neutrophil degranulation"], "271127": ["O-glycosylation of TSR domain-containing proteins"], "271375": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "271424": ["Synthesis of pyrophosphates in the cytosol"], "271457": ["Synthesis of PIPs at the plasma membrane", "Clathrin-mediated endocytosis", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs", "Factors involved in megakaryocyte development and platelet production"], "271639": ["Hedgehog 'off' state"], "271786": ["O-linked glycosylation of mucins"], "271844": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Hydrolysis of LPC"], "271970": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "272031": ["Lysosphingolipid and LPA receptors"], "27204": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "27207": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "27214": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "272158": ["Fanconi Anemia Pathway"], "27219": ["Stimuli-sensing channels"], "27222": ["Ion homeostasis", "Ion transport by P-type ATPases"], "27223": ["SUMOylation of transcription factors", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "27224": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "27226": ["Synthesis, secretion, and deacylation of Ghrelin"], "272347": ["Generic Transcription Pathway"], "272381": ["Receptor-type tyrosine-protein phosphatases"], "272411": ["O-linked glycosylation of mucins"], "272428": ["Conjugation of salicylate with glycine"], "272551": ["Unwinding of DNA"], "27261": ["Neutrophil degranulation"], "272636": ["Glycosphingolipid metabolism"], "27273": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "27274": ["Generic Transcription Pathway"], "27277": ["Intra-Golgi traffic"], "27279": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "27354": ["DNA Damage/Telomere Stress Induced Senescence", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "G2/M DNA damage checkpoint"], "27357": ["Glycogen synthesis", "Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "27359": ["Platelet degranulation "], "27360": ["Miscellaneous transport and binding events"], "27361": ["Protein repair"], "27364": ["Serine biosynthesis"], "27366": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "27369": ["Purine salvage"], "27370": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "27371": ["VEGFA-VEGFR2 Pathway"], "27373": ["WNT mediated activation of DVL", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Major pathway of rRNA processing in the nucleolus and cytosol", "AURKA Activation by TPX2"], "27374": ["RMTs methylate histone arginines", "Regulation of TP53 Activity through Methylation"], "27376": ["Organic anion transporters", "Gluconeogenesis"], "27377": ["Processing of SMDT1"], "27384": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "27388": ["Synthesis of PS"], "27392": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "27393": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "27395": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "27397": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "27398": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "27399": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IPs in the nucleus"], "27400": ["The canonical retinoid cycle in rods (twilight vision)"], "27401": ["APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "SCF(Skp2)-mediated degradation of p27/p21", "Ub-specific processing proteases", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "Regulation of RUNX2 expression and activity", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "27402": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "27403": ["ABC transporters in lipid homeostasis"], "27404": ["ABC-family proteins mediated transport"], "27405": ["Iron uptake and transport"], "27409": ["ABC transporters in lipid homeostasis"], "27410": ["ABC transporters in lipid homeostasis", "Surfactant metabolism"], "27411": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "27412": ["Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "27413": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "27419": ["HS-GAG degradation"], "27421": ["ABC-family proteins mediated transport"], "27425": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "27494": ["Signaling by Hippo"], "27632": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "276770": ["Hypusine synthesis from eIF5A-lysine"], "27681": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "276846": ["Attachment of GPI anchor to uPAR"], "276919": ["snRNP Assembly"], "277250": ["HDMs demethylate histones"], "277328": ["TRP channels"], "277360": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "27756": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "277753": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "27784": ["Neddylation"], "277935": ["Olfactory Signaling Pathway"], "277939": ["Anchoring of the basal body to the plasma membrane"], "277973": ["Sodium/Proton exchangers"], "27801": ["HDL assembly"], "278679": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "279028": ["O-glycosylation of TSR domain-containing proteins"], "279561": ["Stimuli-sensing channels"], "27966": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "27967": ["mRNA Splicing - Major Pathway"], "27979": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "27993": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "27998": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "27999": ["Platelet degranulation "], "28000": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "28019": ["HATs acetylate histones"], "28028": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "280287": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "28030": ["Mitochondrial translation elongation"], "28035": ["mRNA Splicing - Major Pathway"], "280408": ["MHC class II antigen presentation"], "28042": ["Synthesis of PE"], "280635": ["Molecules associated with elastic fibres"], "280645": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "28071": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "28077": ["Generic Transcription Pathway"], "28084": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "28105": ["Antigen processing: Ubiquitination & Proteasome degradation"], "28113": ["DNA Damage/Telomere Stress Induced Senescence"], "28135": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "28146": ["XBP1(S) activates chaperone genes"], "28169": ["Synthesis of PA", "COPI-independent Golgi-to-ER retrograde traffic"], "28185": ["Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases"], "28193": ["Olfactory Signaling Pathway"], "28199": ["Neddylation"], "28200": ["RA biosynthesis pathway", "Peroxisomal protein import"], "28240": ["TRP channels", "Neutrophil degranulation"], "28248": ["Recycling of bile acids and salts", "Transport of organic anions"], "28250": ["Recycling of bile acids and salts", "Transport of organic anions"], "28253": ["Recycling of bile acids and salts", "Transport of organic anions"], "28254": ["Recycling of bile acids and salts", "Transport of organic anions"], "282663": ["Neutrophil degranulation"], "286940": ["ISG15 antiviral mechanism"], "286942": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "29806": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "29807": ["Vitamin B1 (thiamin) metabolism"], "29808": ["Transcriptional Regulation by E2F6"], "29810": ["Regulation of HSF1-mediated heat shock response"], "29813": ["Regulation of TP53 Activity through Association with Co-factors", "Transcriptional  activation of  cell cycle inhibitor p21 "], "29816": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "29817": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "29857": ["NOD1/2 Signaling Pathway", "CDO in myogenesis", "DSCAM interactions", "VEGFA-VEGFR2 Pathway"], "29858": ["Synthesis of GDP-mannose"], "29859": ["Cytosolic sulfonation of small molecules"], "29863": ["G alpha (s) signalling events"], "29870": ["G2/M Checkpoints", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "29871": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "29873": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation"], "29875": ["Nephrin family interactions", "RHO GTPases activate IQGAPs", "MAP2K and MAPK activation", "Neutrophil degranulation"], "30044": ["G alpha (q) signalling events", "Opsins"], "30049": ["Fatty acyl-CoA biosynthesis"], "30050": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "30053": ["Antimicrobial peptides"], "30060": ["Post-translational modification: synthesis of GPI-anchored proteins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "30791": ["Zinc influx into cells by the SLC39 gene family"], "30800": ["Collagen degradation", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures"], "30805": ["Organic cation transport"], "30806": ["O-glycosylation of TSR domain-containing proteins"], "30838": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "30839": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "30841": ["HDMs demethylate histones"], "30843": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "30877": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "30878": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "30924": ["Assembly of active LPL and LIPC lipase complexes"], "30925": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "30930": ["WNT ligand biogenesis and trafficking"], "30931": ["Cargo recognition for clathrin-mediated endocytosis"], "30934": ["Cargo recognition for clathrin-mediated endocytosis"], "30937": ["Surfactant metabolism"], "30938": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "30939": ["APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Separation of Sister Chromatids"], "30940": ["Ub-specific processing proteases"], "30941": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases"], "30942": ["Nuclear Receptor transcription pathway"], "30944": ["Generic Transcription Pathway"], "30945": ["Antigen processing: Ubiquitination & Proteasome degradation"], "30948": ["Clathrin-mediated endocytosis"], "30949": ["Cyclin A/B1/B2 associated events during G2/M transition"], "30951": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "30955": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "30956": ["Lysine catabolism"], "30960": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "30962": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "30963": ["Synthesis of very long-chain fatty acyl-CoAs"], "317653": ["Formation of the cornified envelope"], "317677": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "317717": ["COPII-mediated vesicle transport"], "317750": ["Sodium/Calcium exchangers"], "319148": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "319149": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "319150": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "319151": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "319152": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "319153": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "319154": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "319155": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319156": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319157": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319158": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319159": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319160": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319161": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319162": ["HDACs deacetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "319163": ["HDACs deacetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "319164": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319165": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319166": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319167": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319170": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319171": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319172": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319176": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319177": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319178": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319179": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319181": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319184": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319186": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319189": ["HDACs deacetylate histones", "HATs acetylate histones"], "319190": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319191": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319192": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "319197": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "319229": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "319239": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (s) signalling events"], "319322": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "319352": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "319415": ["HS-GAG biosynthesis"], "319430": ["Peptide ligand-binding receptors", "Regulation of Complement cascade"], "319446": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "319480": ["Integrin cell surface interactions"], "319504": ["Neurofascin interactions"], "319518": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "319520": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "319530": ["Generic Transcription Pathway"], "319554": ["Cholesterol biosynthesis"], "319579": ["Beta defensins", "Defensins"], "319583": ["Nonhomologous End-Joining (NHEJ)"], "319594": ["Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha"], "319642": ["Neutrophil degranulation", "Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "319651": ["Ub-specific processing proteases"], "319655": ["Cytosolic sulfonation of small molecules"], "319660": ["Triglyceride biosynthesis"], "319734": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "319757": ["Hedgehog 'off' state", "BBSome-mediated cargo-targeting to cilium", "Hedgehog 'on' state", "Activation of SMO"], "319767": ["Ion transport by P-type ATPases"], "319801": ["TP53 Regulates Metabolic Genes"], "319845": ["BBSome-mediated cargo-targeting to cilium"], "319899": ["Factors involved in megakaryocyte development and platelet production"], "319901": ["Dermatan sulfate biosynthesis"], "319924": ["Dopamine Neurotransmitter Release Cycle"], "319934": ["RAB GEFs exchange GTP for GDP on RABs"], "319939": ["MET interacts with TNS proteins"], "319944": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "319945": ["Vitamin B2 (riboflavin) metabolism"], "319955": ["B-WICH complex positively regulates rRNA expression", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "RNA Polymerase I Transcription Initiation"], "319974": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "319991": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "320024": ["LDL clearance"], "320082": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "320083": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "320091": ["Stimuli-sensing channels"], "320118": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "320127": ["Effects of PIP2 hydrolysis"], "320129": ["G alpha (s) signalling events", "Cargo recognition for clathrin-mediated endocytosis"], "320183": ["Protein repair"], "320202": ["Platelet degranulation "], "320204": ["Protein methylation"], "320207": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "320213": ["SUMO is proteolytically processed"], "320225": ["Sperm Motility And Taxes"], "320244": ["Carboxyterminal post-translational modifications of tubulin"], "320271": ["RHO GTPases Activate Formins"], "320299": ["Anchoring of the basal body to the plasma membrane"], "320311": ["E3 ubiquitin ligases ubiquitinate target proteins"], "320332": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "320355": ["Synthesis of PA"], "320394": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "320404": ["Synthesis of IP3 and IP4 in the cytosol"], "320415": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "320435": ["RAB GEFs exchange GTP for GDP on RABs"], "320438": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "320452": ["Collagen biosynthesis and modifying enzymes"], "320484": ["Regulation of RAS by GAPs"], "320560": ["RAB GEFs exchange GTP for GDP on RABs"], "320581": ["Cholesterol biosynthesis"], "320632": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "320634": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Rho GTPase cycle", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "320635": ["Erythrocytes take up carbon dioxide and release oxygen"], "320685": ["Interconversion of nucleotide di- and triphosphates"], "320707": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "320713": ["Metalloprotease DUBs"], "320714": ["RAB GEFs exchange GTP for GDP on RABs"], "320718": ["Multifunctional anion exchangers"], "320727": ["Transcriptional regulation by small RNAs"], "320769": ["Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "320772": ["Post-translational modification: synthesis of GPI-anchored proteins"], "320795": ["RHO GTPases activate PKNs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "320806": ["Mitochondrial translation termination"], "320808": ["Neddylation"], "320832": ["Cell surface interactions at the vascular wall", "DAP12 interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "320840": ["Post-translational modification: synthesis of GPI-anchored proteins"], "320864": ["Keratinization", "Formation of the cornified envelope"], "320865": ["Adherens junctions interactions"], "320873": ["Adherens junctions interactions"], "320910": ["Molecules associated with elastic fibres", "Integrin cell surface interactions"], "320940": ["Ion transport by P-type ATPases"], "320981": ["Glycerophospholipid catabolism"], "320997": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "321006": ["Antigen processing: Ubiquitination & Proteasome degradation"], "321019": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "321020": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "326618": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "326619": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "326620": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "326623": ["TNFs bind their physiological receptors"], "327655": ["Synthesis of pyrophosphates in the cytosol"], "327762": ["Removal of the Flap Intermediate from the C-strand", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Removal of the Flap Intermediate"], "327799": ["Ub-specific processing proteases"], "327814": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "327826": ["PI3K Cascade", "PIP3 activates AKT signaling", "Frs2-mediated activation", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Activated NTRK2 signals through FRS2 and FRS3"], "327942": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "327958": ["Synthesis of PI"], "327987": ["Generic Transcription Pathway"], "328099": ["5-Phosphoribose 1-diphosphate biosynthesis"], "328234": ["Antigen processing: Ubiquitination & Proteasome degradation"], "328417": ["Nicotinamide salvaging"], "328561": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "328563": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "328572": ["Regulation of gene expression by Hypoxia-inducible Factor", "Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Attenuation phase", "SUMOylation of transcription cofactors", "B-WICH complex positively regulates rRNA expression", "CD209 (DC-SIGN) signaling", "Metalloprotease DUBs", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Methylation", "PI5P Regulates TP53 Acetylation", "Activation of the TFAP2 (AP-2) family of transcription factors", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX3 regulates NOTCH signaling", "Regulation of RUNX3 expression and activity", "RUNX3 regulates p14-ARF", "Estrogen-dependent gene expression", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Regulation of FOXO transcriptional activity by acetylation"], "328580": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "328699": ["GABA A (rho) receptor activation"], "328778": ["RAB geranylgeranylation"], "328779": ["HS-GAG biosynthesis"], "328833": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "328845": ["Synthesis of very long-chain fatty acyl-CoAs"], "328967": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "329065": ["Fatty acyl-CoA biosynthesis"], "329152": ["Antigen processing: Ubiquitination & Proteasome degradation"], "329165": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "329178": ["Stimuli-sensing channels"], "329244": ["Interleukin-20 family signaling"], "329251": ["Regulation of PLK1 Activity at G2/M Transition", "RHO GTPases activate PKNs", "RHO GTPases activate PAKs"], "329252": ["Regulation of FZD by ubiquitination"], "329260": ["RAB GEFs exchange GTP for GDP on RABs"], "329278": ["ECM proteoglycans"], "329416": ["NOSTRIN mediated eNOS trafficking"], "329460": ["Olfactory Signaling Pathway"], "329502": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC"], "329547": ["Toll Like Receptor 4 (TLR4) Cascade", "Neutrophil degranulation", "Antimicrobial peptides"], "329727": ["RAB GEFs exchange GTP for GDP on RABs"], "329777": ["Attachment of GPI anchor to uPAR"], "329795": ["Anchoring of the basal body to the plasma membrane"], "329877": ["RAB GEFs exchange GTP for GDP on RABs"], "329908": ["Ub-specific processing proteases"], "329910": ["Mitochondrial Fatty Acid Beta-Oxidation"], "329934": ["AKT phosphorylates targets in the nucleus", "Regulation of localization of FOXO transcription factors"], "329941": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Collagen chain trimerization"], "329954": ["Sperm Motility And Taxes"], "330010": ["Carboxyterminal post-translational modifications of tubulin"], "330064": ["Vitamin B5 (pantothenate) metabolism", "Transport of vitamins, nucleosides, and related molecules"], "330119": ["Collagen biosynthesis and modifying enzymes", "O-glycosylation of TSR domain-containing proteins"], "330122": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "330192": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "330222": ["SDK interactions"], "330260": ["Synthesis of 5-eicosatetraenoic acids"], "330267": ["O-glycosylation of TSR domain-containing proteins"], "330301": ["Generic Transcription Pathway"], "330319": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs"], "330369": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "330450": ["Wax biosynthesis"], "330463": ["Generic Transcription Pathway"], "330496": ["Interleukin-20 family signaling"], "330554": ["Fanconi Anemia Pathway"], "330662": ["Regulation of actin dynamics for phagocytic cup formation", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "Factors involved in megakaryocyte development and platelet production"], "330817": ["Hypusine synthesis from eIF5A-lysine"], "330836": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "330908": ["Post-translational modification: synthesis of GPI-anchored proteins"], "330914": ["Rho GTPase cycle"], "330953": ["HCN channels"], "330959": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "331004": ["Sodium/Proton exchangers"], "331374": ["Effects of PIP2 hydrolysis"], "331401": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "331461": ["Receptor-type tyrosine-protein phosphatases", "Interleukin-38 signaling"], "332131": ["Keratinization", "Formation of the cornified envelope"], "332396": ["TWIK-related spinal cord K+ channel (TRESK)", "Phase 4 - resting membrane potential"], "332579": ["CLEC7A (Dectin-1) signaling"], "332937": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "333050": ["MAP2K and MAPK activation"], "333329": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "VxPx cargo-targeting to cilium"], "333424": ["O-linked glycosylation of mucins"], "333433": ["Synthesis of PA"], "333639": ["NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling"], "333654": ["Regulation of TP53 Activity through Association with Co-factors"], "333883": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "3338896": ["Respiratory electron transport", "Complex I biogenesis"], "3338902": ["Respiratory electron transport", "Complex I biogenesis"], "337924": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "338320": ["Cargo concentration in the ER"], "338337": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "338350": ["Mitochondrial Fatty Acid Beta-Oxidation"], "338362": ["Dermatan sulfate biosynthesis"], "338365": ["Metal ion SLC transporters"], "338370": ["Stimuli-sensing channels"], "338374": ["Interleukin-20 family signaling"], "338375": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "338521": ["Sphingolipid de novo biosynthesis"], "338523": ["HDMs demethylate histones"], "353148": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "353155": ["Gap junction assembly"], "353165": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "353166": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "353167": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "353169": ["Cellular hexose transport"], "353187": ["Nuclear Receptor transcription pathway"], "353190": ["mRNA decay by 5' to 3' exoribonuclease"], "353204": ["Platelet degranulation ", "Neutrophil degranulation", "Gluconeogenesis"], "353242": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "353258": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "353310": ["Generic Transcription Pathway"], "353325": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "353328": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "353344": ["G alpha (i) signalling events", "Opsins"], "353371": ["Utilization of Ketone Bodies"], "360198": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "360211": ["Beta defensins", "Defensins"], "360216": ["Ovarian tumor domain proteases"], "368203": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "373864": ["Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "MET activates PTK2 signaling", "Collagen chain trimerization"], "380608": ["Rho GTPase cycle"], "380614": ["Hedgehog 'off' state"], "380660": ["Synthesis of Ketone Bodies"], "380664": ["Depolymerisation of the Nuclear Lamina"], "380698": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "380711": ["Rap1 signalling"], "380718": ["Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane"], "380728": ["Voltage gated Potassium channels"], "380836": ["Miscellaneous transport and binding events"], "380839": ["Neutrophil degranulation"], "380840": ["Mitochondrial iron-sulfur cluster biogenesis"], "380921": ["Effects of PIP2 hydrolysis"], "380928": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "380997": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "381038": ["Processing of SMDT1"], "381073": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "381091": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling"], "381101": ["Purine catabolism"], "381112": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "381122": ["Degradation of the extracellular matrix"], "381236": ["Formation of the cornified envelope"], "381286": ["Neutrophil degranulation"], "381290": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "381293": ["RHO GTPases activate CIT"], "381308": ["Neutrophil degranulation"], "381318": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "381399": ["Antimicrobial peptides"], "381406": ["Regulation of TP53 Activity through Phosphorylation"], "381413": ["G alpha (s) signalling events"], "381417": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "381484": ["Cell surface interactions at the vascular wall", "DAP12 interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "381489": ["G alpha (s) signalling events", "Relaxin receptors"], "381511": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "381534": ["Antigen processing: Ubiquitination & Proteasome degradation"], "381549": ["Generic Transcription Pathway"], "381605": ["TBC/RABGAPs"], "381644": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "381677": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "381694": ["O-glycosylation of TSR domain-containing proteins"], "381810": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "381812": ["Neutrophil degranulation"], "381853": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "381903": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "381925": ["Role of phospholipids in phagocytosis"], "381944": ["Ub-specific processing proteases"], "382014": ["Stimuli-sensing channels", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "382030": ["Depolymerisation of the Nuclear Lamina"], "382051": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "382053": ["Phase I - Functionalization of compounds", "LDL clearance"], "382090": ["Anchoring of the basal body to the plasma membrane"], "382105": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "382106": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "382109": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "382118": ["Generic Transcription Pathway"], "382156": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "382207": ["HATs acetylate histones"], "382348": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "382427": ["Stimuli-sensing channels"], "382551": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "382571": ["Voltage gated Potassium channels"], "382913": ["Cleavage of the damaged pyrimidine ", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "382985": ["Interconversion of nucleotide di- and triphosphates"], "383295": ["Neutrophil degranulation"], "383548": ["Neutrophil degranulation"], "383563": ["G alpha (s) signalling events"], "383619": ["The AIM2 inflammasome"], "384309": ["Regulation of innate immune responses to cytosolic DNA"], "384701": ["Ub-specific processing proteases"], "384732": ["Olfactory Signaling Pathway"], "384763": ["Generic Transcription Pathway"], "384783": ["PI3K Cascade", "IRS-mediated signalling", "SOS-mediated signalling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "PI3K/AKT activation", "IRS-related events triggered by IGF1R", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS"], "384997": ["Antimicrobial peptides"], "385643": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "G alpha (i) signalling events", "Post-translational protein phosphorylation"], "386612": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "386750": ["Receptor-type tyrosine-protein phosphatases"], "387285": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "387339": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387340": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387341": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387342": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387343": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387344": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387345": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387346": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387347": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387348": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387349": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387351": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387352": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387353": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387354": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387355": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387356": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387512": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387513": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387515": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "387524": ["Antigen processing: Ubiquitination & Proteasome degradation"], "387616": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "393082": ["Neutrophil degranulation"], "394252": ["Neutrophil degranulation"], "394430": ["Glucuronidation"], "394432": ["Glucuronidation"], "394433": ["Glucuronidation", "Heme degradation"], "394434": ["Glucuronidation"], "394435": ["Glucuronidation"], "394436": ["Glucuronidation", "Heme degradation"], "396184": ["Downstream signaling of activated FGFR1"], "399548": ["Phase 0 - rapid depolarisation"], "399558": ["Downstream signaling of activated FGFR1"], "399566": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "399673": ["Hedgehog 'on' state"], "399674": ["Hedgehog 'on' state"], "399675": ["Hedgehog 'on' state"], "399676": ["Hedgehog 'on' state"], "403172": ["Beta defensins", "Defensins"], "404195": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "404222": ["Olfactory Signaling Pathway"], "404310": ["Olfactory Signaling Pathway"], "404316": ["Olfactory Signaling Pathway"], "404317": ["Olfactory Signaling Pathway"], "404318": ["Olfactory Signaling Pathway"], "404319": ["Olfactory Signaling Pathway"], "404322": ["Olfactory Signaling Pathway"], "404324": ["Olfactory Signaling Pathway"], "404328": ["Olfactory Signaling Pathway"], "404329": ["Olfactory Signaling Pathway"], "404331": ["Olfactory Signaling Pathway"], "404346": ["Olfactory Signaling Pathway"], "404473": ["Olfactory Signaling Pathway"], "404545": ["Stimuli-sensing channels"], "404549": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "404710": ["RHO GTPases activate IQGAPs"], "406176": ["Olfactory Signaling Pathway"], "406186": ["Olfactory Signaling Pathway"], "406218": ["Electric Transmission Across Gap Junctions"], "406219": ["Keratinization", "Formation of the cornified envelope"], "406220": ["Keratinization", "Formation of the cornified envelope"], "406221": ["Keratinization", "Formation of the cornified envelope"], "406223": ["Keratinization", "Formation of the cornified envelope"], "407785": ["Respiratory electron transport", "Complex I biogenesis"], "407786": ["Ub-specific processing proteases", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "407821": ["Regulation of FZD by ubiquitination"], "408058": ["Activation of BIM and translocation to mitochondria ", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Macroautophagy", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "408068": ["Generic Transcription Pathway"], "408196": ["Formation of the cornified envelope"], "414084": ["Ovarian tumor domain proteases"], "415115": ["Neddylation"], "432530": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "432600": ["Keratinization"], "432720": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "432879": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "432940": ["Regulation of TNFR1 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "433016": ["Formation of the cornified envelope"], "433099": ["Platelet degranulation "], "433180": ["Formation of the cornified envelope"], "433182": ["Gluconeogenesis"], "433256": ["Synthesis of very long-chain fatty acyl-CoAs"], "433292": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "433323": ["Sphingolipid de novo biosynthesis"], "433375": ["Neutrophil degranulation"], "433586": ["NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling"], "433702": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "RNA Polymerase II Pre-transcription Events", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing", "Processing of Capped Intron-Containing Pre-mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "Processing of Intronless Pre-mRNAs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "433759": ["G0 and Early G1", "Formation of the beta-catenin:TCF transactivating complex", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "HDACs deacetylate histones", "Deactivation of the beta-catenin transactivating complex", "SUMOylation of chromatin organization proteins", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity", "Factors involved in megakaryocyte development and platelet production"], "433766": ["Antigen processing: Ubiquitination & Proteasome degradation"], "433926": ["Miscellaneous transport and binding events"], "433931": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "434121": ["Cytosolic sulfonation of small molecules"], "434130": ["Neddylation"], "434203": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "434233": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "434246": ["Smooth Muscle Contraction"], "434264": ["Cytosolic sulfonation of small molecules"], "434437": ["Glycine degradation"], "434440": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "435273": ["Keratinization"], "435285": ["Keratinization"], "435350": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "435528": ["Conjugation of benzoate with glycine"], "435802": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "435818": ["Cellular hexose transport"], "435927": ["Recycling of bile acids and salts", "Transport of organic anions"], "436059": ["Phase I - Functionalization of compounds"], "436440": ["G alpha (i) signalling events", "Free fatty acid receptors"], "436522": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "436523": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "442801": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "442835": ["Beta defensins", "Defensins"], "445007": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "446099": ["Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "448987": ["FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "449521": ["Generic Transcription Pathway"], "494124": ["Neutrophil degranulation"], "494448": ["Oxidative Stress Induced Senescence", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "494546": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "497652": ["DNA Damage/Telomere Stress Induced Senescence"], "503558": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "503844": ["Adherens junctions interactions"], "503847": ["Neutrophil degranulation", "Antimicrobial peptides"], "50490": ["Detoxification of Reactive Oxygen Species"], "50492": ["Antigen processing: Ubiquitination & Proteasome degradation"], "50493": ["Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "Metabolism of ingested MeSeO2H into MeSeH", "TP53 Regulates Metabolic Genes"], "50496": ["Transcriptional Regulation by E2F6"], "50497": ["Regulation of HSF1-mediated heat shock response"], "50498": ["Interleukin-35 Signalling", "Interleukin-27 signaling"], "50500": ["Vitamin E"], "50501": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "50505": ["HDR through Single Strand Annealing (SSA)", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Fanconi Anemia Pathway"], "50523": ["Signaling by Hippo"], "50527": ["Insulin processing", "Detoxification of Reactive Oxygen Species"], "50529": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "50530": ["Elastic fibre formation", "Molecules associated with elastic fibres"], "50701": ["Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Neutrophil degranulation", "Antimicrobial peptides", "Regulation of Complement cascade"], "50702": ["Regulation of Complement cascade"], "50708": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "50709": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "50721": ["Processing of DNA double-strand break ends"], "50723": ["Costimulation by the CD28 family"], "50724": ["HDACs deacetylate histones"], "50754": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "50757": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "50760": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "50762": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "50764": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "50765": ["Transferrin endocytosis and recycling"], "50767": ["Glycerophospholipid catabolism"], "50768": ["Rho GTPase cycle"], "50769": ["Ion transport by P-type ATPases"], "50770": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "50771": ["Ion transport by P-type ATPases"], "50772": ["MAPK6/MAPK4 signaling"], "50773": ["Purine catabolism"], "50778": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "50779": ["G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "50780": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "50782": ["G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "50783": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "50784": ["Sphingolipid de novo biosynthesis"], "50785": ["HS-GAG biosynthesis"], "50786": ["HS-GAG biosynthesis"], "50787": ["HS-GAG biosynthesis"], "50788": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "50789": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "50790": ["Synthesis of very long-chain fatty acyl-CoAs"], "50793": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "50797": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "50798": ["Sialic acid metabolism"], "50799": ["Gluconeogenesis"], "50817": ["Degradation of the extracellular matrix"], "50868": ["Ub-specific processing proteases", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "50873": ["Pink/Parkin Mediated Mitophagy", "Josephin domain DUBs", "Antigen processing: Ubiquitination & Proteasome degradation"], "50874": ["Striated Muscle Contraction"], "50875": ["Striated Muscle Contraction"], "50876": ["Striated Muscle Contraction"], "50877": ["Glycosphingolipid metabolism"], "50880": ["Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "50883": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "G2/M DNA damage checkpoint", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "50884": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "50905": ["Interleukin-17 signaling"], "50907": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "50908": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "50909": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "50911": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "50912": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "50915": ["Tie2 Signaling"], "50917": ["Keratan sulfate degradation", "Neutrophil degranulation"], "50929": ["Interleukin-20 family signaling"], "50930": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "50931": ["Interleukin-35 Signalling", "Interleukin-27 signaling"], "50932": ["Oxidative Stress Induced Senescence"], "50933": ["UCH proteinases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Neddylation"], "50934": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "50935": ["Sialic acid metabolism"], "50995": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "50996": ["mRNA Splicing - Minor Pathway"], "51786": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "51788": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "51791": ["G alpha (i) signalling events"], "51792": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "AURKA Activation by TPX2", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "51793": ["eNOS activation"], "51796": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "51797": ["Interconversion of nucleotide di- and triphosphates"], "51798": ["Peroxisomal protein import"], "51801": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "51810": ["mRNA Splicing - Major Pathway"], "51812": ["HATs acetylate histones", "UCH proteinases", "DNA Damage Recognition in GG-NER"], "51813": ["Generic Transcription Pathway", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "51869": ["Nonhomologous End-Joining (NHEJ)"], "51885": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "51897": ["Macroautophagy"], "52014": ["Synthesis of Dolichyl-phosphate"], "52028": ["BBSome-mediated cargo-targeting to cilium"], "52036": ["COPII-mediated vesicle transport"], "52118": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Nectin/Necl  trans heterodimerization"], "52120": ["HS-GAG degradation", "Neutrophil degranulation"], "52123": ["Synthesis of PA"], "52150": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "52163": ["Activation of RAC1 downstream of NMDARs"], "52187": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "52206": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "52245": ["Neddylation"], "52250": ["Olfactory Signaling Pathway"], "52276": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "52331": ["Neutrophil degranulation"], "52348": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "52428": ["RHO GTPases Activate Rhotekin and Rhophilins"], "52440": ["Regulation of TNFR1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "52443": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "52466": ["Metabolism of folate and pterines", "Iron uptake and transport"], "52504": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "52538": ["Mitochondrial Fatty Acid Beta-Oxidation"], "52563": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "52588": ["Neutrophil degranulation"], "52589": ["Activation of Ca-permeable Kainate Receptor"], "52615": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "SUMOylation of chromatin organization proteins", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "52633": ["Neutrophil degranulation"], "52635": ["Glycosphingolipid metabolism"], "52639": ["Macroautophagy"], "52666": ["G alpha (q) signalling events"], "52679": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "52683": ["Condensation of Prophase Chromosomes"], "52685": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "52690": ["PKMTs methylate histone lysines"], "52696": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "52705": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "52710": ["Vitamin B2 (riboflavin) metabolism"], "52712": ["Generic Transcription Pathway"], "52713": ["Surfactant metabolism"], "52717": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6"], "52815": ["Mitochondrial protein import"], "52846": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "52855": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "52858": ["Synthesis of PI"], "52864": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "52906": ["Anchoring of the basal body to the plasma membrane"], "53310": ["Unblocking of NMDA receptors, glutamate binding and activation", "Activation of Ca-permeable Kainate Receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Synaptic adhesion-like molecules"], "53312": ["Neddylation"], "53313": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "53317": ["mRNA Splicing - Major Pathway"], "53319": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "53320": ["Amino acid synthesis and interconversion (transamination)"], "53323": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "53325": ["Regulation of TP53 Activity through Association with Co-factors"], "53328": ["Neutrophil degranulation"], "53330": ["Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "53332": ["Synthesis of PIPs at the plasma membrane"], "53333": ["Pink/Parkin Mediated Mitophagy"], "53334": ["COPI-mediated anterograde transport", "Intra-Golgi traffic"], "53356": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "53357": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Role of phospholipids in phagocytosis", "COPI-independent Golgi-to-ER retrograde traffic"], "53374": ["Chondroitin sulfate biosynthesis"], "53376": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases", "Regulation of TP53 Degradation"], "53378": ["Ephrin signaling", "Neurofascin interactions", "Neutrophil degranulation"], "53379": ["mRNA Splicing - Major Pathway"], "53381": ["Neutrophil degranulation"], "53412": ["Glycogen synthesis"], "53413": ["Insulin processing", "VxPx cargo-targeting to cilium"], "53414": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "53417": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Neddylation"], "53418": ["N-Glycan antennae elongation"], "53419": ["Physiological factors"], "53421": ["XBP1(S) activates chaperone genes"], "53424": ["Small interfering RNA (siRNA) biogenesis"], "53598": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "53603": ["Interleukin-7 signaling"], "53607": ["mRNA Splicing - Major Pathway"], "53611": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "53614": ["Post-translational modification: synthesis of GPI-anchored proteins"], "53617": ["Keratinization", "Formation of the cornified envelope"], "53618": ["Reactions specific to the complex N-glycan synthesis pathway"], "53621": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "53623": ["Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Synaptic adhesion-like molecules"], "53625": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "53814": ["Regulation of ornithine decarboxylase (ODC)"], "53817": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "53856": ["Neutrophil degranulation"], "53857": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "53859": ["CD28 dependent PI3K/Akt signaling", "Dectin-1 mediated noncanonical NF-kB signaling", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "53867": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "53868": ["RAB geranylgeranylation"], "53869": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "TBC/RABGAPs", "RAB geranylgeranylation"], "53881": ["Inositol transporters"], "53885": ["Anchoring of the basal body to the plasma membrane"], "53892": ["Transcriptional regulation by RUNX2"], "53893": ["Phosphate bond hydrolysis by NUDT proteins"], "53896": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "53945": ["Metal ion SLC transporters", "Iron uptake and transport"], "53972": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHA-mediated growth cone collapse"], "53973": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "53975": ["snRNP Assembly"], "53978": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "54004": ["RHO GTPases Activate Formins"], "54123": ["DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "TICAM1-dependent activation of IRF3/IRF7", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"], "54125": ["Nonhomologous End-Joining (NHEJ)"], "54126": ["EGFR downregulation", "NRAGE signals death through JNK", "Rho GTPase cycle", "Ephrin signaling"], "54127": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "54128": ["Synthesis of GDP-mannose"], "54130": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "54131": ["ISG15 antiviral mechanism", "IRF3 mediated activation of type 1 IFN", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN", "TICAM1-dependent activation of IRF3/IRF7", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "54140": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "54150": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "54152": ["Retrograde neurotrophin signalling"], "54153": ["Regulation of RAS by GAPs"], "54159": ["Neutrophil degranulation", "Antimicrobial peptides"], "54160": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "54161": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "54167": ["PIP3 activates AKT signaling", "Costimulation by the CD28 family", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "54169": ["HATs acetylate histones"], "54170": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "54188": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "54197": ["ABC-family proteins mediated transport", "ER Quality Control Compartment (ERQC)"], "54198": ["WNT ligand biogenesis and trafficking", "Ub-specific processing proteases"], "54199": ["Chemokine receptors bind chemokines"], "54200": ["Cytosolic sulfonation of small molecules"], "54214": ["Retrograde transport at the Trans-Golgi-Network"], "54216": ["Platelet degranulation "], "54219": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "54324": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "54325": ["Synthesis of very long-chain fatty acyl-CoAs"], "54326": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "54338": ["Vitamin C (ascorbate) metabolism"], "54342": ["Synthesis of UDP-N-acetyl-glucosamine"], "54343": ["PKMTs methylate histone lysines"], "54353": ["Signal regulatory protein family interactions"], "54364": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "54368": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "54371": ["Keratan sulfate biosynthesis"], "54375": ["Regulation of ornithine decarboxylase (ODC)"], "54376": ["Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "54377": ["Presynaptic depolarization and calcium channel opening", "Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "54378": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "54383": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "54384": ["Synthesis of PIPs at the late endosome membrane"], "54391": ["Vitamin B2 (riboflavin) metabolism"], "54392": ["Condensation of Prometaphase Chromosomes"], "54393": ["Activation of G protein gated Potassium channels", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "GABA B receptor activation", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "54397": ["Fatty acyl-CoA biosynthesis"], "54399": ["COPI-mediated anterograde transport", "Intra-Golgi traffic"], "54401": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "mTOR signalling", "mTORC1-mediated signalling", "Signaling by Hippo", "Rap1 signalling", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "54403": ["Bicarbonate transporters"], "54405": ["Respiratory electron transport", "Complex I biogenesis"], "54409": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "54411": ["Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "54426": ["MET Receptor Activation"], "54445": ["Trafficking and processing of endosomal TLR"], "54447": ["Glycosphingolipid metabolism"], "54448": ["Interleukin-36 pathway"], "54450": ["Interleukin-36 pathway"], "54451": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "544710": ["Keratinization"], "54473": ["Neutrophil degranulation", "Interleukin-1 signaling"], "544748": ["Olfactory Signaling Pathway"], "544817": ["Rho GTPase cycle"], "54483": ["The NLRP3 inflammasome"], "54485": ["NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "54486": ["Glutathione conjugation", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "544922": ["Generic Transcription Pathway"], "544963": ["RHO GTPases activate IQGAPs", "Neutrophil degranulation"], "544971": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "545123": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "545140": ["Olfactory Signaling Pathway"], "545156": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "G alpha (q) signalling events", "MAPK6/MAPK4 signaling"], "54519": ["Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "MAP2K and MAPK activation"], "545205": ["Olfactory Signaling Pathway"], "545260": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "545288": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "545291": ["HS-GAG degradation"], "545366": ["Regulation of Complement cascade"], "545378": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "545475": ["Beta defensins", "Defensins"], "545481": ["Rho GTPase cycle"], "545486": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "545622": ["EGFR downregulation"], "54563": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "545725": ["Mitochondrial transcription termination"], "545812": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "545817": ["Miscellaneous substrates", "Xenobiotics"], "545975": ["Sphingolipid de novo biosynthesis"], "54598": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "54601": ["AKT phosphorylates targets in the nucleus", "Ub-specific processing proteases", "Regulation of localization of FOXO transcription factors", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of cell cycle genes"], "54607": ["Neddylation"], "54609": ["Cargo recognition for clathrin-mediated endocytosis"], "54611": ["cGMP effects", "G alpha (s) signalling events"], "54613": ["Keratan sulfate biosynthesis", "Sialic acid metabolism"], "54615": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "546161": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "54624": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "54631": ["Nephrin family interactions"], "54633": ["mRNA Splicing - Major Pathway"], "54635": ["Signaling by PDGF"], "54636": ["Macroautophagy"], "54638": ["Neddylation"], "54652": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "54667": ["Ion transport by P-type ATPases"], "54670": ["Ion transport by P-type ATPases"], "54672": ["Neutrophil degranulation"], "546726": ["Vitamins", "RA biosynthesis pathway"], "546747": ["Olfactory Signaling Pathway"], "54678": ["Generic Transcription Pathway"], "54683": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes"], "54698": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "54709": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "54710": ["HS-GAG biosynthesis"], "54712": ["Other semaphorin interactions"], "54721": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "54725": ["Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "547253": ["Nicotinamide salvaging"], "547431": ["Butyrophilin (BTN) family interactions"], "552899": ["Glucuronidation"], "554292": ["Neutrophil degranulation"], "55925": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "55936": ["Interconversion of nucleotide di- and triphosphates"], "55938": ["Retinoid metabolism and transport"], "55944": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "55947": ["Fanconi Anemia Pathway"], "55948": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "55950": ["Neutrophil degranulation"], "55961": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "55963": ["Amino acid transport across the plasma membrane"], "55978": ["Intraflagellar transport"], "55979": ["Synthesis of PA", "ChREBP activates metabolic gene expression"], "55980": ["Synthesis of IP2, IP, and Ins in the cytosol"], "55981": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "55982": ["Nonhomologous End-Joining (NHEJ)"], "55984": ["CaMK IV-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Activation of RAC1 downstream of NMDARs"], "55985": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "55989": ["SUMOylation of RNA binding proteins", "Major pathway of rRNA processing in the nucleolus and cytosol"], "55990": ["FMO oxidises nucleophiles"], "55991": ["Electric Transmission Across Gap Junctions", "The NLRP3 inflammasome"], "55994": ["Signaling by BMP"], "56012": ["Gluconeogenesis"], "56015": ["Olfactory Signaling Pathway"], "56016": ["Neutrophil degranulation"], "56017": ["Cellular hexose transport", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "56018": ["Synthesis of PC"], "56031": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neutrophil degranulation", "mRNA Splicing - Major Pathway"], "56041": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "56044": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "56045": ["Nucleobase catabolism"], "56047": ["Post-translational modification: synthesis of GPI-anchored proteins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "56050": ["Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Endogenous sterols"], "56055": ["Platelet degranulation "], "56075": ["Ubiquinol biosynthesis"], "56077": ["Effects of PIP2 hydrolysis"], "56078": ["Reversible hydration of carbon dioxide"], "56085": ["Cargo recognition for clathrin-mediated endocytosis"], "56086": ["Condensation of Prophase Chromosomes", "HuR (ELAVL1) binds and stabilizes mRNA"], "56089": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "56092": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "56094": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "56150": ["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "56174": ["Synthesis of UDP-N-acetyl-glucosamine"], "56176": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "56183": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "56185": ["Peroxisomal lipid metabolism", "Peroxisomal protein import"], "56187": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation"], "56188": ["Ion homeostasis", "Ion transport by P-type ATPases"], "56189": ["Glyoxylate metabolism and glycine degradation", "Proline catabolism"], "56193": ["Platelet degranulation "], "56194": ["mRNA Splicing - Major Pathway"], "56196": ["Nonhomologous End-Joining (NHEJ)"], "56199": ["Mitochondrial ABC transporters"], "56200": ["B-WICH complex positively regulates rRNA expression", "Major pathway of rRNA processing in the nucleolus and cytosol"], "56205": ["MASTL Facilitates Mitotic Progression"], "56207": ["UCH proteinases"], "56208": ["Macroautophagy", "Ub-specific processing proteases"], "56209": ["Glycerophospholipid catabolism"], "56210": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis"], "56212": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Rho GTPase cycle", "RHO GTPases activate KTN1", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "56213": ["Degradation of the extracellular matrix"], "56215": ["Apoptotic cleavage of cellular proteins"], "56216": ["LGI-ADAM interactions"], "56217": ["Tight junction interactions"], "56222": ["Activation of the TFAP2 (AP-2) family of transcription factors"], "56228": ["Antigen processing: Ubiquitination & Proteasome degradation"], "56229": ["O-glycosylation of TSR domain-containing proteins"], "56233": ["SUMOylation of DNA damage response and repair proteins"], "56248": ["Factors involved in megakaryocyte development and platelet production"], "56249": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "56258": ["mRNA Splicing - Major Pathway"], "56273": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "56274": ["Signaling by Hippo"], "56275": ["RUNX2 regulates bone development"], "56280": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "56282": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "56284": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "56297": ["BBSome-mediated cargo-targeting to cilium"], "56299": ["The role of GTSE1 in G2/M progression after G2 checkpoint"], "56305": ["PI and PC transport between ER and Golgi membranes"], "56307": ["Inactivation, recovery and regulation of the phototransduction cascade"], "56310": ["HDACs deacetylate histones"], "56314": ["Generic Transcription Pathway"], "56315": ["Rhesus glycoproteins mediate ammonium transport."], "56316": ["Gamma-carboxylation of protein precursors"], "56317": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "56318": ["Neutrophil degranulation"], "56324": ["EGFR downregulation", "Ub-specific processing proteases", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "56325": ["ABC-family proteins mediated transport"], "56332": ["Signaling by Hippo"], "56334": ["Pre-NOTCH Processing in Golgi", "COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "56335": ["Processing of Capped Intron-Containing Pre-mRNA"], "56336": ["O-linked glycosylation of mucins", "N-Glycan antennae elongation"], "56338": ["The NLRP3 inflammasome"], "56347": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "56348": ["Androgen biosynthesis", "Synthesis of very long-chain fatty acyl-CoAs"], "56349": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "56350": ["Trafficking of myristoylated proteins to the cilium"], "56351": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "Aryl hydrocarbon receptor signalling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "56353": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Transcriptional Regulation by E2F6"], "56354": ["Regulation of HSF1-mediated heat shock response"], "56356": ["Glycosphingolipid metabolism"], "56357": ["Branched-chain amino acid catabolism"], "56358": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "56360": ["Mitochondrial Fatty Acid Beta-Oxidation"], "56362": ["Cytosolic sulfonation of small molecules"], "56365": ["Stimuli-sensing channels"], "56367": ["Retrograde transport at the Trans-Golgi-Network"], "56371": ["Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of Emi1", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A:Cdk2-associated events at S phase entry", "Antigen processing: Ubiquitination & Proteasome degradation"], "56373": ["Metabolism of Angiotensinogen to Angiotensins", "Regulation of Complement cascade"], "56375": ["N-Glycan antennae elongation"], "56378": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "56379": ["Potassium transport channels"], "56382": ["Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "56386": ["O-linked glycosylation of mucins", "N-Glycan antennae elongation"], "56388": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "56389": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "56395": ["COPI-mediated anterograde transport"], "56398": ["Hyaluronan uptake and degradation"], "56401": ["Collagen biosynthesis and modifying enzymes"], "56406": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "56407": ["TRP channels"], "56409": ["Synthesis of pyrophosphates in the cytosol"], "56417": ["C6 deamination of adenosine", "Formation of editosomes by ADAR proteins"], "56418": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "56419": ["RHO GTPases Activate Formins"], "56420": ["Processing of DNA double-strand break ends"], "56421": ["Glycolysis"], "56422": ["mRNA decay by 3' to 5' exoribonuclease"], "56424": ["Downregulation of TGF-beta receptor signaling", "Downregulation of ERBB2 signaling", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "56430": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "56433": ["WNT ligand biogenesis and trafficking"], "56436": ["UCH proteinases", "Ub-specific processing proteases"], "56438": ["Recognition of DNA damage by PCNA-containing replication complex", "Prolactin receptor signaling", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Degradation of beta-catenin by the destruction complex", "Degradation of DVL", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Orc1 removal from chromatin", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56442": ["Serine biosynthesis"], "56444": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "56445": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "56447": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "56448": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "56451": ["Citric acid cycle (TCA cycle)"], "56452": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "56453": ["ATF6 (ATF6-alpha) activates chaperones", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "56454": ["Amino acid synthesis and interconversion (transamination)"], "56455": ["Activation of BIM and translocation to mitochondria ", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Macroautophagy", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "56456": ["RMTs methylate histone arginines", "UCH proteinases", "DNA Damage Recognition in GG-NER", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "56458": ["AKT phosphorylates targets in the nucleus", "AKT-mediated inactivation of FOXO1A", "MAPK6/MAPK4 signaling", "Regulation of localization of FOXO transcription factors", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes"], "56459": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "56460": ["Keratinization", "Formation of the cornified envelope"], "56461": ["Phase 1 - inactivation of fast Na+ channels"], "56464": ["MHC class II antigen presentation"], "56468": ["Interleukin-4 and Interleukin-13 signaling", "Neddylation"], "56469": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "Formation of Incision Complex in GG-NER", "Regulation of IFNG signaling"], "56470": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "56473": ["alpha-linolenic acid (ALA) metabolism"], "56480": ["Regulation of innate immune responses to cytosolic DNA", "STAT6-mediated induction of chemokines", "IRF3-mediated induction of type I IFN", "Interleukin-37 signaling", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "56484": ["Signaling by NODAL", "AKT phosphorylates targets in the nucleus", "MAPK6/MAPK4 signaling", "Regulation of localization of FOXO transcription factors", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes"], "56485": ["Neutrophil degranulation", "Intestinal hexose absorption"], "56486": ["Macroautophagy", "TBC/RABGAPs"], "56488": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "56489": ["SUMOylation of immune response proteins", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "56491": ["Sphingolipid de novo biosynthesis"], "56494": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "56495": ["XBP1(S) activates chaperone genes"], "56505": ["Formation of the beta-catenin:TCF transactivating complex", "UCH proteinases", "Ub-specific processing proteases", "DNA Damage Recognition in GG-NER"], "56508": ["Integrin alphaIIb beta3 signaling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion"], "56513": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions", "Asymmetric localization of PCP proteins"], "56515": ["Antigen processing: Ubiquitination & Proteasome degradation"], "56517": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Organic cation transport"], "56520": ["Interconversion of nucleotide di- and triphosphates"], "56525": ["Generic Transcription Pathway"], "56529": ["Synthesis, secretion, and deacylation of Ghrelin"], "56532": ["TRIF-mediated programmed cell death", "TRP channels", "RIPK1-mediated regulated necrosis", "IKK complex recruitment mediated by RIP1"], "56533": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "56535": ["ABC transporters in lipid homeostasis"], "56541": ["Platelet degranulation "], "56543": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "56550": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "IKK complex recruitment mediated by RIP1", "Antigen processing: Ubiquitination & Proteasome degradation"], "56551": ["Degradation of cysteine and homocysteine", "Detoxification of Reactive Oxygen Species"], "56615": ["Glutathione conjugation", "Neutrophil degranulation"], "56622": ["Interaction With The Zona Pellucida"], "56626": ["Nonhomologous End-Joining (NHEJ)"], "56632": ["Sphingolipid de novo biosynthesis"], "56636": ["Cellular hexose transport"], "56637": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "CRMPs in Sema3A signaling", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "B-WICH complex positively regulates rRNA expression"], "56643": ["Proton/oligopeptide cotransporters"], "56690": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "56692": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "MAP2K and MAPK activation", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "56693": ["Collagen biosynthesis and modifying enzymes"], "56696": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "56697": ["Factors involved in megakaryocyte development and platelet production"], "56698": ["RNA polymerase II transcribes snRNA genes"], "56702": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "56705": ["L1CAM interactions", "RAF/MAP kinase cascade", "MET activates RAS signaling"], "56708": ["IL-6-type cytokine receptor ligand interactions"], "56715": ["RAB GEFs exchange GTP for GDP on RABs"], "56716": ["PIP3 activates AKT signaling", "Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "56717": ["PIP3 activates AKT signaling", "Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "56720": ["Tryptophan catabolism"], "56727": ["Synthesis of IP2, IP, and Ins in the cytosol"], "56735": ["Keratinization", "Formation of the cornified envelope"], "56736": ["Antigen processing: Ubiquitination & Proteasome degradation"], "56737": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "56738": ["Molybdenum cofactor biosynthesis"], "56743": ["Role of LAT2/NTAL/LAB on calcium mobilization"], "56744": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "56746": ["Post-translational modification: synthesis of GPI-anchored proteins"], "56749": ["Pyrimidine biosynthesis"], "56752": ["Carnitine synthesis"], "56760": ["GPVI-mediated activation cascade"], "56771": ["Generic Transcription Pathway"], "56773": ["Keratan sulfate biosynthesis"], "56774": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "56791": ["ISG15 antiviral mechanism", "Termination of translesion DNA synthesis", "Antigen processing: Ubiquitination & Proteasome degradation"], "56794": ["Alpha-oxidation of phytanate", "Peroxisomal protein import"], "56808": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "56811": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "56835": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "56839": ["LGI-ADAM interactions"], "56843": ["TRP channels"], "56847": ["RA biosynthesis pathway"], "56857": ["Gluconeogenesis"], "56858": ["Olfactory Signaling Pathway"], "56861": ["Olfactory Signaling Pathway"], "56869": ["Generic Transcription Pathway"], "57014": ["Neurotransmitter receptors and postsynaptic signal transmission"], "57138": ["Cation-coupled Chloride cotransporters"], "57170": ["Synthesis of Dolichyl-phosphate"], "57249": ["GABA A receptor activation"], "57252": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "57253": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "57256": ["Post-translational modification: synthesis of GPI-anchored proteins"], "57257": ["GPVI-mediated activation cascade", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "EPH-ephrin mediated repulsion of cells", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability"], "57260": ["Leukotriene receptors", "G alpha (q) signalling events"], "57264": ["Neutrophil degranulation"], "57265": ["Ca2+ pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "57269": ["Olfactory Signaling Pathway"], "57270": ["Olfactory Signaling Pathway"], "57271": ["Olfactory Signaling Pathway"], "57274": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "57279": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "57294": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "L13a-mediated translational silencing of Ceruloplasmin expression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Major pathway of rRNA processing in the nucleolus and cytosol", "Mitotic Prometaphase", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "57295": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "57296": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "57312": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "57315": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "57316": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "57317": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "57320": ["SUMOylation of transcription cofactors"], "57321": ["DNA Damage/Telomere Stress Induced Senescence"], "57344": ["Methylation"], "57349": ["Platelet degranulation ", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "57357": ["Androgen biosynthesis", "Synthesis of Dolichyl-phosphate"], "57370": ["N-Glycan antennae elongation"], "57376": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "57385": ["P2Y receptors", "G alpha (i) signalling events"], "57423": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "57432": ["RNA polymerase II transcribes snRNA genes"], "57434": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "57436": ["Macroautophagy"], "57437": ["Neutrophil degranulation"], "57440": ["Factors involved in megakaryocyte development and platelet production"], "574402": ["Leukotriene receptors", "G alpha (q) signalling events", "P2Y receptors", "G alpha (i) signalling events"], "57441": ["CDT1 association with the CDC6:ORC:origin complex", "Activation of the pre-replicative complex"], "574417": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "574418": ["Serine biosynthesis"], "57442": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "57738": ["Proton/oligopeptide cotransporters"], "57741": ["Regulation of TP53 Activity through Phosphorylation"], "57743": ["XBP1(S) activates chaperone genes"], "57745": ["Generic Transcription Pathway"], "57748": ["Regulation of TP53 Activity through Methylation"], "57750": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "57751": ["Antigen processing: Ubiquitination & Proteasome degradation"], "57757": ["Antimicrobial peptides"], "57764": ["Netrin-1 signaling"], "57776": ["Stimuli-sensing channels"], "57778": ["RHO GTPases Activate Formins"], "57780": ["Ion homeostasis", "Ion transport by P-type ATPases"], "57781": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "57783": ["Ovarian tumor domain proteases"], "57785": ["Phase 0 - rapid depolarisation"], "57810": ["CDO in myogenesis", "Ligand-receptor interactions", "Activation of SMO"], "57811": ["G alpha (i) signalling events", "Opsins"], "57813": ["Pyrimidine salvage"], "57814": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "57837": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "57874": ["Synthesis of very long-chain fatty acyl-CoAs"], "57875": ["Assembly of active LPL and LIPC lipase complexes"], "57890": ["Interleukin-17 signaling"], "57905": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "57913": ["TP53 Regulates Transcription of Caspase Activators and Caspases"], "57914": ["Interleukin-7 signaling"], "57915": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "57916": ["TNFs bind their physiological receptors"], "58170": ["Stimuli-sensing channels"], "58175": ["G alpha (i) signalling events", "G alpha (z) signalling events"], "58176": ["Rhesus glycoproteins mediate ammonium transport."], "58179": ["DAP12 interactions", "DAP12 signaling"], "58181": ["Interleukin-20 family signaling"], "58182": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "58184": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "58186": ["Recognition of DNA damage by PCNA-containing replication complex", "E3 ubiquitin ligases ubiquitinate target proteins"], "58194": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Reelin signalling pathway", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "58205": ["PD-1 signaling"], "58206": ["Recognition of DNA damage by PCNA-containing replication complex"], "58217": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "DAP12 interactions"], "58220": ["Tight junction interactions"], "58222": ["Neutrophil degranulation", "RAB geranylgeranylation"], "58223": ["Degradation of the extracellular matrix"], "58230": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "58231": ["Signaling by Hippo"], "58233": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "58235": ["Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "58242": ["Synthesis of pyrophosphates in the cytosol"], "58244": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "58246": ["Transport of nucleotide sugars"], "58250": ["Chondroitin sulfate biosynthesis"], "58518": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "58800": ["TRP channels"], "58801": ["Activation of NOXA and translocation to mitochondria", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "58802": ["Ca2+ activated K+ channels"], "58804": ["MAPK6/MAPK4 signaling"], "58805": ["PKA-mediated phosphorylation of key metabolic factors", "ChREBP activates metabolic gene expression"], "58807": ["Transport of organic anions"], "58810": ["Glutathione conjugation", "Formation of xylulose-5-phosphate"], "58859": ["Molecules associated with elastic fibres"], "58861": ["Leukotriene receptors", "G alpha (q) signalling events"], "58875": ["Branched-chain amino acid catabolism"], "58909": ["Rho GTPase cycle"], "58911": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "58988": ["AKT phosphorylates targets in the nucleus"], "58991": ["G alpha (q) signalling events", "Synthesis, secretion, and deacylation of Ghrelin"], "58992": ["Intrinsic Pathway of Fibrin Clot Formation"], "58994": ["Glycosphingolipid metabolism", "TNFR1-mediated ceramide production"], "58996": ["Rho GTPase cycle"], "58998": ["Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "59001": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "59004": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "59005": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "59007": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "59008": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "59009": ["Antigen processing: Ubiquitination & Proteasome degradation"], "59010": ["Sulfide oxidation to sulfate"], "59013": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway"], "59015": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "59021": ["Golgi Cisternae Pericentriolar Stack Reorganization", "RAB geranylgeranylation"], "59024": ["Generic Transcription Pathway"], "59025": ["Ub-specific processing proteases"], "59026": ["Neutrophil degranulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "59027": ["Nicotinamide salvaging"], "59028": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "59029": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "59031": ["Chondroitin sulfate biosynthesis"], "59033": ["Bicarbonate transporters"], "59035": ["RMTs methylate histone arginines", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Estrogen-dependent gene expression"], "59036": ["Degradation of DVL"], "59040": ["Rho GTPase cycle", "Ub-specific processing proteases"], "59042": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "59043": ["Neddylation"], "59044": ["Antigen processing: Ubiquitination & Proteasome degradation"], "59045": ["Pregnenolone biosynthesis"], "59046": ["MASTL Facilitates Mitotic Progression"], "59047": ["APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "59048": ["O-linked glycosylation of mucins"], "59054": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "59056": ["Hedgehog 'on' state", "Activation of SMO"], "59079": ["Signaling by ERBB2", "Downregulation of ERBB2 signaling"], "59095": ["Ion homeostasis", "Ion transport by P-type ATPases"], "59125": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "59126": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "59287": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Neutrophil degranulation", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "59288": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "59310": ["Smooth Muscle Contraction"], "595136": ["Respiratory electron transport", "Complex I biogenesis"], "60321": ["mRNA Splicing - Major Pathway"], "60322": ["Chondroitin sulfate biosynthesis"], "60365": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "60367": ["Receptor-type tyrosine-protein phosphatases"], "60406": ["HDACs deacetylate histones"], "60409": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "60411": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "60441": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "60504": ["Interleukin-21 signaling"], "60505": ["Interleukin-21 signaling"], "60510": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "60525": ["Transcriptional activation of mitochondrial biogenesis", "Ethanol oxidation"], "60532": ["Processing of Capped Intron-Containing Pre-mRNA"], "60533": ["PD-1 signaling"], "60534": ["Fanconi Anemia Pathway"], "60594": ["Degradation of the extracellular matrix"], "60595": ["Platelet degranulation "], "60599": ["Regulation of TP53 Activity through Phosphorylation"], "60613": ["Voltage gated Potassium channels"], "619310": ["Generic Transcription Pathway"], "619326": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "619331": ["Generic Transcription Pathway"], "619332": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "619548": ["Beta defensins", "Defensins"], "620235": ["DAP12 interactions"], "620631": ["Intraflagellar transport"], "621603": ["Sphingolipid de novo biosynthesis"], "621823": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "621893": ["HDACs deacetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "622127": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "622402": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "622434": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "622629": ["Keratinization"], "623279": ["RET signaling"], "623503": ["Peptide ligand-binding receptors"], "623661": ["Glyoxylate metabolism and glycine degradation"], "624153": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "624219": ["Assembly of active LPL and LIPC lipase complexes"], "624855": ["SCF(Skp2)-mediated degradation of p27/p21", "Cyclin D associated events in G1"], "624910": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "624957": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "625249": ["Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Biosynthesis of E-series 18(S)-resolvins"], "625530": ["Ub-specific processing proteases"], "626615": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "626834": ["Formation of the cornified envelope"], "628779": ["HS-GAG biosynthesis"], "628900": ["Platelet degranulation ", "Neutrophil degranulation"], "629114": ["Beta defensins", "Defensins"], "629203": ["Cytosolic sulfonation of small molecules"], "629219": ["Cytosolic sulfonation of small molecules"], "629873": ["Keratinization"], "630146": ["Generation of second messenger molecules"], "630294": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "630952": ["Adherens junctions interactions"], "630994": ["Formation of the cornified envelope"], "634104": ["Olfactory Signaling Pathway"], "634504": ["Keratinization"], "636931": ["Antigen processing: Ubiquitination & Proteasome degradation"], "637515": ["The NLRP1 inflammasome"], "638251": ["Cytosolic sulfonation of small molecules"], "63828": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "63856": ["RNA polymerase II transcribes snRNA genes"], "63857": ["Retinoid metabolism and transport"], "63873": ["TRP channels"], "63953": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "63955": ["Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry"], "63959": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "63986": ["Neutrophil degranulation"], "63993": ["Acetylcholine Neurotransmitter Release Cycle", "Transport of bile salts and organic acids, metal ions and amine compounds"], "64008": ["Transport of glycerol from adipocytes to the liver by Aquaporins", "Passive transport by Aquaporins"], "64010": ["Signaling by Hippo"], "64011": ["Long-term potentiation"], "64050": ["Activation of the TFAP2 (AP-2) family of transcription factors"], "64058": ["Formation of the cornified envelope"], "64059": ["Utilization of Ketone Bodies"], "64095": ["Class A/1 (Rhodopsin-like receptors)"], "641340": ["Nuclear Receptor transcription pathway"], "64138": ["Metabolism of Angiotensinogen to Angiotensins", "COPII-mediated vesicle transport", "Lysosome Vesicle Biogenesis", "Cargo concentration in the ER", "Neutrophil degranulation"], "64139": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "64144": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "64177": ["TRP channels"], "64214": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "64242": ["Intracellular oxygen transport"], "64291": ["Synthesis of bile acids and bile salts", "MHC class II antigen presentation"], "64292": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "64337": ["Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "64340": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "64384": ["Transcriptional activation of mitochondrial biogenesis", "Regulation of FOXO transcriptional activity by acetylation"], "64424": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "64435": ["Cell surface interactions at the vascular wall"], "64436": ["Synthesis of PIPs at the Golgi membrane", "ARL13B-mediated ciliary trafficking of INPP5E"], "64452": ["Cellular hexose transport"], "64580": ["HS-GAG biosynthesis"], "64602": ["Iron uptake and transport"], "64654": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR1c and Klotho ligand binding and activation", "FGFR2c ligand binding and activation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Post-translational protein phosphorylation"], "64655": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "64656": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "64657": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "64658": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "64659": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "64660": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "64705": ["Pyrimidine catabolism"], "64706": ["Degradation of the extracellular matrix"], "64707": ["PKMTs methylate histone lysines"], "64818": ["Keratinization", "Formation of the cornified envelope"], "64833": ["Mitochondrial Fatty Acid Beta-Oxidation"], "64898": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "64899": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "64918": ["Sulfur amino acid metabolism"], "64930": ["Macroautophagy", "Inhibition of TSC complex formation by PKB", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "TBC/RABGAPs"], "64931": ["Post-translational modification: synthesis of GPI-anchored proteins"], "64934": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "65020": ["Generic Transcription Pathway"], "65079": ["Axonal growth inhibition (RHOA activation)"], "65086": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "65098": ["Peroxisomal protein import"], "65106": ["Glutamate Neurotransmitter Release Cycle"], "65107": ["Retinoid metabolism and transport"], "65111": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "65112": ["Downregulation of TGF-beta receptor signaling"], "65114": ["WNT ligand biogenesis and trafficking"], "65221": ["Proton/oligopeptide cotransporters"], "65247": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "65254": ["CRMPs in Sema3A signaling"], "65255": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "65256": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "65257": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "654457": ["Beta defensins", "Defensins"], "654458": ["Beta defensins", "Defensins"], "654459": ["Beta defensins", "Defensins"], "654460": ["Beta defensins", "Defensins"], "654465": ["Beta defensins", "Defensins"], "654470": ["Anchoring of the basal body to the plasma membrane"], "654821": ["O-linked glycosylation of mucins"], "65956": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "65961": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "65969": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Vitamin D (calciferol) metabolism", "HDL clearance"], "65973": ["Stimuli-sensing channels", "Ion homeostasis"], "66043": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "66046": ["Respiratory electron transport", "Complex I biogenesis"], "66047": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66050": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "66052": ["Citric acid cycle (TCA cycle)"], "66053": ["Basigin interactions"], "66054": ["Glutathione synthesis and recycling"], "66055": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "66061": ["Intraflagellar transport"], "66065": ["Estrogen biosynthesis"], "66066": ["Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "66069": ["snRNP Assembly"], "66070": ["mRNA Splicing - Major Pathway"], "66071": ["Sulfide oxidation to sulfate"], "66077": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66082": ["Arachidonate production from DAG"], "66083": ["PKMTs methylate histone lysines"], "66085": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "66091": ["Respiratory electron transport", "Complex I biogenesis"], "66094": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "66096": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "66101": ["mRNA Splicing - Major Pathway"], "66102": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "66105": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "IKK complex recruitment mediated by RIP1", "Antigen processing: Ubiquitination & Proteasome degradation"], "66108": ["Respiratory electron transport", "Complex I biogenesis"], "66111": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "66112": ["Phase I - Functionalization of compounds"], "66113": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron remodeling"], "66118": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "66119": ["Pink/Parkin Mediated Mitophagy"], "66121": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66124": ["Josephin domain DUBs"], "66125": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "66128": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66131": ["Processing of DNA double-strand break ends"], "66136": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "66138": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "66140": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "66141": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "66144": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "66147": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "66156": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "66163": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66169": ["Pink/Parkin Mediated Mitophagy"], "66171": ["Pentose phosphate pathway"], "66174": ["Synthesis of dolichyl-phosphate-glucose"], "66183": ["Sphingolipid de novo biosynthesis"], "66190": ["Sphingolipid de novo biosynthesis"], "66194": ["Amino acid synthesis and interconversion (transamination)"], "66198": ["Mitochondrial Fatty Acid Beta-Oxidation"], "66199": ["Neddylation"], "66200": ["Neddylation"], "66201": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "66212": ["XBP1(S) activates chaperone genes"], "66213": ["Generic Transcription Pathway"], "66218": ["Respiratory electron transport", "Complex I biogenesis"], "66222": ["Neutrophil degranulation"], "66223": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66226": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "66230": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66231": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "66234": ["Cholesterol biosynthesis"], "66235": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "66237": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "66240": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "66242": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66248": ["Synthesis of dolichyl-phosphate-glucose"], "66249": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "66251": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "66258": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66262": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "66268": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "66286": ["Synthesis, secretion, and deacylation of Ghrelin"], "66290": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "66292": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66296": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "66310": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "66311": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "66313": ["Signaling by BMP", "Downregulation of TGF-beta receptor signaling", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Hedgehog 'on' state", "Ub-specific processing proteases", "Regulation of RUNX3 expression and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "66317": ["Formation of RNA Pol II elongation complex ", "mRNA decay by 3' to 5' exoribonuclease", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "66333": ["Passive transport by Aquaporins"], "66335": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "66336": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "66340": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "66341": ["SUMOylation of DNA damage response and repair proteins"], "66346": ["Respiratory electron transport", "Complex I biogenesis"], "66350": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "66352": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "66354": ["NOTCH1 Intracellular Domain Regulates Transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Notch-HLH transcription pathway", "mRNA Splicing - Major Pathway", "RUNX3 regulates NOTCH signaling"], "66355": ["Purine salvage"], "66358": ["Phosphate bond hydrolysis by NUDT proteins"], "66362": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "66371": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "66373": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "66377": ["Respiratory electron transport", "Complex I biogenesis"], "66380": ["Keratinization"], "66383": ["Mitochondrial iron-sulfur cluster biogenesis"], "66394": ["NOSIP mediated eNOS trafficking"], "66397": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Chylomicron assembly", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "66398": ["Neddylation"], "66401": ["Detoxification of Reactive Oxygen Species"], "66402": ["Ion homeostasis", "Ion transport by P-type ATPases"], "66403": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "66407": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66410": ["Pink/Parkin Mediated Mitophagy"], "66413": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "66414": ["Respiratory electron transport", "Complex I biogenesis"], "66416": ["Respiratory electron transport", "Complex I biogenesis"], "66419": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66420": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "66423": ["RMTs methylate histone arginines"], "66427": ["Phase I - Functionalization of compounds"], "66440": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "66441": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "66442": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "66443": ["PI Metabolism"], "66446": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "66447": ["Glutathione conjugation"], "66448": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66454": ["Nicotinate metabolism"], "66464": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "66467": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "66468": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "66473": ["Activation of Matrix Metalloproteinases"], "66475": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "66481": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "66482": ["Insulin processing", "VxPx cargo-targeting to cilium"], "66491": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "66493": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66494": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "66495": ["Respiratory electron transport", "Complex I biogenesis"], "66498": ["Neddylation"], "665033": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "66508": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "665095": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "66510": ["E3 ubiquitin ligases ubiquitinate target proteins"], "66511": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "665113": ["Oxidative Stress Induced Senescence"], "66513": ["NOD1/2 Signaling Pathway", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "66514": ["Phenylalanine and tyrosine catabolism"], "66515": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "665270": ["Acyl chain remodelling of PC", "Retinoid metabolism and transport"], "66538": ["Regulation of HSF1-mediated heat shock response"], "665433": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "66552": ["Regulation of TNFR1 signaling"], "66556": ["Signaling by NODAL", "Signaling by Activin"], "665563": ["Metabolism of folate and pterines"], "66557": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Antimicrobial peptides", "Post-translational protein phosphorylation"], "66568": ["SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "66570": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "66573": ["Hedgehog 'on' state"], "66578": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "66583": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "66585": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "66586": ["Acyl chain remodelling of PG", "Synthesis of CL"], "66588": ["Interconversion of nucleotide di- and triphosphates"], "66589": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "665891": ["Keratinization"], "66592": ["Processing of SMDT1"], "66593": ["Release of apoptotic factors from the mitochondria", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC, XIAP-regulated apoptotic response"], "66597": ["ER Quality Control Compartment (ERQC)"], "665992": ["Keratinization"], "665998": ["Keratinization"], "66603": ["snRNP Assembly"], "66612": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "66615": ["Macroautophagy"], "66616": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "666168": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "66618": ["mRNA Splicing - Major Pathway"], "66624": ["Synthesis, secretion, and deacylation of Ghrelin"], "666279": ["ECM proteoglycans"], "666311": ["Generic Transcription Pathway"], "66632": ["Synthesis of diphthamide-EEF2"], "66634": ["Activation of ATR in response to replication stress", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "666348": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "66642": ["mRNA Splicing - Major Pathway"], "66646": ["Pentose phosphate pathway"], "666468": ["Macroautophagy"], "66647": ["SUMOylation of DNA damage response and repair proteins"], "66653": ["RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "66659": ["Synthesis of PA"], "66663": ["Antigen processing: Ubiquitination & Proteasome degradation"], "66671": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Cyclin A/B1/B2 associated events during G2/M transition", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "66676": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "66679": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "66681": ["Glycogen synthesis", "Neutrophil degranulation", "Pentose phosphate pathway"], "66682": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "66687": ["TBC/RABGAPs"], "66691": ["Clathrin-mediated endocytosis", "RAB GEFs exchange GTP for GDP on RABs"], "66700": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "667034": ["Neutrophil degranulation", "Purine catabolism"], "66706": ["Complex I biogenesis"], "66708": ["Keratinization"], "66713": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation", "Clathrin-mediated endocytosis"], "66724": ["NOD1/2 Signaling Pathway", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "66725": ["PTK6 promotes HIF1A stabilization"], "66727": ["Acyl chain remodelling of PE"], "667271": ["Olfactory Signaling Pathway"], "667277": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "66733": ["Voltage gated Potassium channels"], "66734": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy"], "66743": ["Antigen processing: Ubiquitination & Proteasome degradation"], "66753": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis"], "66772": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "66775": ["Synthesis of very long-chain fatty acyl-CoAs"], "66786": ["Olfactory Signaling Pathway"], "66789": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "66795": ["Macroautophagy"], "667977": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "66799": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "667992": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "66809": ["Keratinization", "Formation of the cornified envelope"], "66810": ["mRNA Splicing - Major Pathway"], "668101": ["Cell surface interactions at the vascular wall", "DAP12 interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "66812": ["Coenzyme A biosynthesis"], "668137": ["Cleavage of Growing Transcript in the Termination Region ", "ISG15 antiviral mechanism", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Deadenylation of mRNA", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "66815": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "668173": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "668178": ["Neutrophil degranulation"], "66824": ["CLEC7A/inflammasome pathway", "Neutrophil degranulation", "The NLRP3 inflammasome"], "668257": ["Acyl chain remodeling of DAG and TAG"], "66826": ["Acyl chain remodeling of CL"], "668303": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "66834": ["Mitochondrial Fatty Acid Beta-Oxidation"], "668359": ["Hedgehog 'on' state"], "66836": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "66840": ["Macroautophagy"], "66841": ["Respiratory electron transport"], "66844": ["Sphingolipid de novo biosynthesis"], "66845": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66848": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "66853": ["Acyl chain remodeling of DAG and TAG", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "66857": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC"], "66865": ["Processing of SMDT1"], "66866": ["Platelet degranulation "], "668758": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "66877": ["mRNA Splicing - Major Pathway"], "66878": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "66885": ["Branched-chain amino acid catabolism"], "66887": ["Peroxisomal protein import"], "66889": ["Ub-specific processing proteases", "Ovarian tumor domain proteases"], "66890": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "66894": ["Regulation of PTEN stability and activity", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "66899": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "66901": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "66902": ["Methionine salvage pathway"], "66904": ["Biotin transport and metabolism", "Propionyl-CoA catabolism"], "66905": ["Retrograde transport at the Trans-Golgi-Network"], "66913": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "66914": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "66916": ["Respiratory electron transport", "Complex I biogenesis"], "66925": ["Citric acid cycle (TCA cycle)"], "66934": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Neutrophil degranulation", "Mitotic Prometaphase"], "66940": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "66945": ["Citric acid cycle (TCA cycle)"], "66948": ["Branched-chain amino acid catabolism"], "66973": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "66975": ["RAB GEFs exchange GTP for GDP on RABs"], "66977": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "66979": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "66983": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "66993": ["RMTs methylate histone arginines", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "66997": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "66998": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "67005": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "67013": ["Regulation of Apoptosis"], "67014": ["HDMs demethylate histones"], "67023": ["COPI-dependent Golgi-to-ER retrograde traffic"], "67030": ["Fanconi Anemia Pathway"], "67037": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "67040": ["SUMOylation of transcription cofactors"], "67041": ["Utilization of Ketone Bodies"], "67042": ["Intraflagellar transport"], "67045": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "67046": ["TBC/RABGAPs"], "670464": ["Keratinization"], "670472": ["Keratinization"], "670482": ["Keratinization"], "670496": ["Keratinization"], "67052": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "67053": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "670533": ["Keratinization"], "67054": ["Purine ribonucleoside monophosphate biosynthesis"], "67057": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Transcriptional Regulation by E2F6"], "67059": ["Platelet degranulation "], "67065": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "67068": ["Intraflagellar transport"], "67071": ["CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation"], "67072": ["Platelet degranulation "], "67073": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane"], "67075": ["Miscellaneous transport and binding events", "Neutrophil degranulation"], "67087": ["Deactivation of the beta-catenin transactivating complex"], "67089": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "670895": ["Keratinization"], "67091": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "67092": ["Creatine metabolism"], "67096": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "67097": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "67111": ["Neurotransmitter release cycle"], "67112": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "67121": ["MASTL Facilitates Mitotic Progression"], "67123": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "67126": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "67128": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "67130": ["Respiratory electron transport", "Complex I biogenesis"], "67133": ["Post-translational modification: synthesis of GPI-anchored proteins"], "67134": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "67135": ["Antimicrobial peptides"], "67138": ["Antigen processing: Ubiquitination & Proteasome degradation"], "67139": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "67141": ["SCF-beta-TrCP mediated degradation of Emi1", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of Emi1", "Mitotic Metaphase/Anaphase Transition"], "67151": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "671535": ["Nicotinamide salvaging"], "67155": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "67161": ["Anchoring of the basal body to the plasma membrane"], "67164": ["Glyoxylate metabolism and glycine degradation"], "67168": ["G alpha (q) signalling events", "P2Y receptors"], "67177": ["CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "67178": ["mRNA Splicing - Minor Pathway"], "67181": ["Depolymerisation of the Nuclear Lamina"], "67184": ["Respiratory electron transport", "Complex I biogenesis"], "671878": ["Metabolism of polyamines"], "671917": ["SUMOylation of DNA damage response and repair proteins"], "67196": ["Fanconi Anemia Pathway", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "67197": ["mRNA Splicing - Minor Pathway"], "67203": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "67204": ["L13a-mediated translational silencing of Ceruloplasmin expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "Recycling of eIF2:GDP"], "67205": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "67207": ["mRNA decay by 5' to 3' exoribonuclease"], "67212": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "67213": ["Neutrophil degranulation"], "67216": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE"], "67225": ["mRNA Splicing - Minor Pathway"], "67231": ["COPII-mediated vesicle transport"], "67235": ["Generic Transcription Pathway"], "67241": ["SUMOylation of DNA damage response and repair proteins"], "67242": ["snRNP Assembly"], "67245": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "67247": ["Phase I - Functionalization of compounds"], "67260": ["Sphingolipid de novo biosynthesis"], "67264": ["Mitochondrial protein import", "Respiratory electron transport", "Complex I biogenesis"], "67268": ["Ephrin signaling", "Smooth Muscle Contraction"], "672682": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "67270": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "67273": ["Respiratory electron transport", "Complex I biogenesis"], "67279": ["Generic Transcription Pathway"], "67283": ["Vitamin B1 (thiamin) metabolism"], "67285": ["mRNA Splicing - Major Pathway"], "67286": ["Intraflagellar transport"], "67287": ["Nicotinamide salvaging"], "67292": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "67295": ["RAB geranylgeranylation"], "67299": ["MET activates RAP1 and RAC1", "Factors involved in megakaryocyte development and platelet production"], "67300": ["Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "67305": ["Detoxification of Reactive Oxygen Species"], "67308": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "67311": ["Sialic acid metabolism"], "67331": ["Ion transport by P-type ATPases"], "67332": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "67337": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "67338": ["Regulation of TP53 Degradation"], "67344": ["Intraflagellar transport"], "67345": ["Antigen processing: Ubiquitination & Proteasome degradation"], "67365": ["Pyrimidine salvage"], "67371": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "67374": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions"], "67375": ["Nicotinate metabolism"], "67378": ["BBSome-mediated cargo-targeting to cilium"], "67381": ["Generic Transcription Pathway"], "67383": ["Histidine catabolism"], "67384": ["Regulation of HSF1-mediated heat shock response", "TNF signaling"], "67399": ["RET signaling"], "67405": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "67414": ["Pink/Parkin Mediated Mitophagy", "Factors involved in megakaryocyte development and platelet production"], "67418": ["mRNA Splicing - Major Pathway"], "67420": ["Wax biosynthesis"], "67422": ["Synthesis of Dolichyl-phosphate"], "67427": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "67432": ["Glyoxylate metabolism and glycine degradation"], "67439": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "67443": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "TBC/RABGAPs", "Receptor Mediated Mitophagy"], "67451": ["Keratinization", "Formation of the cornified envelope"], "67452": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE"], "67455": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "67460": ["mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "67464": ["Phosphate bond hydrolysis by NTPDase proteins"], "67465": ["mRNA Splicing - Major Pathway"], "67466": ["Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "67470": ["ABC transporters in lipid homeostasis"], "67473": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "67474": ["Neutrophil degranulation", "Intra-Golgi traffic"], "67475": ["Insulin processing"], "67480": ["mRNA Splicing - Major Pathway"], "67486": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "67490": ["Antigen processing: Ubiquitination & Proteasome degradation"], "67498": ["Voltage gated Potassium channels"], "67500": ["mRNA Splicing - Major Pathway"], "67511": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "67512": ["Synthesis of PA", "Neutrophil degranulation"], "67526": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy"], "67528": ["Peroxisomal lipid metabolism", "Peroxisomal protein import"], "675294": ["Keratinization"], "67532": ["Molecules associated with elastic fibres"], "67533": ["Receptor-type tyrosine-protein phosphatases"], "67534": ["Carboxyterminal post-translational modifications of tubulin"], "67542": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "67543": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "67547": ["Zinc influx into cells by the SLC39 gene family"], "67556": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "67561": ["Recognition of DNA damage by PCNA-containing replication complex", "Ub-specific processing proteases", "Fanconi Anemia Pathway"], "67569": ["N-Glycan antennae elongation"], "67573": ["Crosslinking of collagen fibrils"], "675812": ["Generic Transcription Pathway"], "67582": ["Transport of inorganic cations/anions and amino acids/oligopeptides"], "67588": ["Downregulation of ERBB2:ERBB3 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "67590": ["Anchoring of the basal body to the plasma membrane"], "67602": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "67603": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "67605": ["mTOR signalling", "mTORC1-mediated signalling", "AKT phosphorylates targets in the cytosol", "HSF1-dependent transactivation"], "67615": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "67618": ["Vitamin B5 (pantothenate) metabolism"], "67619": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "67629": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "67630": ["Sphingolipid de novo biosynthesis"], "67634": ["Iron uptake and transport"], "67655": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "67661": ["Hedgehog 'off' state", "Intraflagellar transport"], "67665": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "67669": ["Regulation of HSF1-mediated heat shock response"], "67673": ["Formation of RNA Pol II elongation complex ", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "67674": ["Methylation", "Eukaryotic Translation Termination"], "67676": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "67678": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "67680": ["Citric acid cycle (TCA cycle)"], "67681": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "67689": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "67694": ["Intraflagellar transport"], "67703": ["Nephrin family interactions"], "67707": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "67710": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "67711": ["SUMOylation of DNA damage response and repair proteins"], "677156": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "67717": ["Digestion of dietary lipid"], "67725": ["Interconversion of nucleotide di- and triphosphates"], "67727": ["COPII-mediated vesicle transport"], "67728": ["Synthesis of diphthamide-EEF2"], "67731": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "67733": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "NRIF signals cell death from the nucleus", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "67738": ["ESR-mediated signaling"], "67755": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "67758": ["Phase I - Functionalization of compounds"], "67760": ["Glutamate Neurotransmitter Release Cycle", "Amino acid transport across the plasma membrane"], "67768": ["Methylation", "Eukaryotic Translation Termination"], "67771": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation", "Clathrin-mediated endocytosis"], "67772": ["Deactivation of the beta-catenin transactivating complex"], "67773": ["HATs acetylate histones"], "67775": ["Olfactory Signaling Pathway"], "67781": ["Neutrophil degranulation"], "67784": ["Other semaphorin interactions"], "67790": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "67792": ["G alpha (i) signalling events"], "67795": ["Nicotinamide salvaging"], "67797": ["mRNA Splicing - Minor Pathway"], "67800": ["Acyl chain remodeling of DAG and TAG", "Triglyceride biosynthesis"], "67804": ["Golgi Associated Vesicle Biogenesis"], "67819": ["ABC-family proteins mediated transport", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "67821": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "67824": ["Urea cycle"], "67834": ["Citric acid cycle (TCA cycle)"], "67836": ["MAP2K and MAPK activation"], "67839": ["G alpha (i) signalling events"], "67840": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "67841": ["Macroautophagy"], "67844": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "67845": ["Antigen processing: Ubiquitination & Proteasome degradation"], "67849": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Resolution of Sister Chromatid Cohesion"], "67857": ["COPII-mediated vesicle transport"], "67861": ["Estrogen biosynthesis", "Retinoid metabolism and transport"], "67862": ["Neutrophil degranulation"], "67863": ["Gluconeogenesis"], "67865": ["G alpha (i) signalling events"], "67870": ["Methionine salvage pathway"], "67871": ["Mitochondrial translation termination"], "67872": ["SUMOylation of DNA damage response and repair proteins"], "67873": ["Methionine salvage pathway"], "67876": ["Respiratory electron transport"], "67880": ["Formation of xylulose-5-phosphate"], "67895": ["Cytosolic tRNA aminoacylation", "Pyrophosphate hydrolysis"], "67897": ["mRNA Capping", "RNA Pol II CTD phosphorylation and interaction with CE"], "67902": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "67909": ["O-linked glycosylation of mucins"], "67911": ["Generic Transcription Pathway"], "67912": ["Neutrophil degranulation"], "67916": ["Sphingolipid de novo biosynthesis"], "67921": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "67923": ["Formation of RNA Pol II elongation complex ", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "67938": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs"], "67941": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "67942": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "67951": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "67952": ["Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases"], "67955": ["The NLRP3 inflammasome"], "67956": ["Condensation of Prophase Chromosomes", "PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation"], "67958": ["mRNA Splicing - Major Pathway"], "67959": ["mRNA Splicing - Major Pathway"], "67963": ["Neutrophil degranulation", "LDL clearance"], "67967": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "67972": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "67973": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "67980": ["Glycolysis"], "67988": ["Platelet degranulation "], "67993": ["Nicotinamide salvaging"], "67994": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "67996": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "68010": ["Downregulation of TGF-beta receptor signaling"], "68014": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "68018": ["Sphingolipid de novo biosynthesis"], "68021": ["Phase I - Functionalization of compounds"], "68024": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "68026": ["Termination of translesion DNA synthesis"], "68031": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "68036": ["Generic Transcription Pathway"], "68038": ["Platelet degranulation "], "68039": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "68041": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "68044": ["Glutathione synthesis and recycling"], "68052": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "68055": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "68058": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "68089": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "68092": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "RNA Polymerase II Pre-transcription Events", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing", "Processing of Capped Intron-Containing Pre-mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "Processing of Intronless Pre-mRNAs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "68094": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "68097": ["Activation of BMF and translocation to mitochondria", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Macroautophagy", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Intraflagellar transport", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "68098": ["Translesion Synthesis by POLH", "Antigen processing: Ubiquitination & Proteasome degradation"], "68106": ["mRNA decay by 3' to 5' exoribonuclease"], "68115": ["Processing of SMDT1"], "68117": ["Platelet degranulation "], "68118": ["Macroautophagy"], "68121": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "68133": ["Glyoxylate metabolism and glycine degradation", "Glycine degradation"], "68134": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "68135": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "68137": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "68142": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "68146": ["ARL13B-mediated ciliary trafficking of INPP5E"], "68149": ["Ovarian tumor domain proteases"], "68151": ["WNT ligand biogenesis and trafficking"], "68153": ["RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "68165": ["Mitochondrial iron-sulfur cluster biogenesis", "Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin"], "68183": ["mRNA Splicing - Major Pathway"], "68188": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "68194": ["Respiratory electron transport", "Complex I biogenesis"], "68195": ["Neutrophil degranulation"], "68196": ["Attenuation phase", "HSF1-dependent transactivation"], "68197": ["Respiratory electron transport", "Neutrophil degranulation", "Complex I biogenesis"], "68198": ["Respiratory electron transport", "Complex I biogenesis"], "68202": ["Respiratory electron transport", "Complex I biogenesis"], "68214": ["Glutathione conjugation", "Vitamin C (ascorbate) metabolism"], "68219": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "68240": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate"], "68251": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "68255": ["Acyl chain remodelling of PC"], "68259": ["Intraflagellar transport"], "68262": ["Synthesis of PA"], "68263": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "68267": ["Organic anion transporters"], "68268": ["eNOS activation"], "68273": ["O-linked glycosylation"], "68275": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "SUMOylation of DNA damage response and repair proteins", "Regulation of HSF1-mediated heat shock response", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate"], "68278": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "68279": ["TRP channels"], "68298": ["Condensation of Prometaphase Chromosomes"], "68299": ["Retrograde transport at the Trans-Golgi-Network"], "68311": ["Post-translational modification: synthesis of GPI-anchored proteins"], "68312": ["Glutathione conjugation"], "68318": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "68328": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "68342": ["Respiratory electron transport", "Complex I biogenesis"], "68349": ["Respiratory electron transport", "Complex I biogenesis"], "68350": ["Ub-specific processing proteases"], "68365": ["Synthesis of PIPs at the plasma membrane", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "68375": ["Respiratory electron transport", "Complex I biogenesis"], "68393": ["Triglyceride biosynthesis"], "68401": ["Gluconeogenesis"], "68404": ["Post-translational modification: synthesis of GPI-anchored proteins"], "68421": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "68428": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "Transferrin endocytosis and recycling"], "68431": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "68441": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "E3 ubiquitin ligases ubiquitinate target proteins", "Regulation of PTEN gene transcription"], "68449": ["TBC/RABGAPs"], "68453": ["Post-translational modification: synthesis of GPI-anchored proteins", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling"], "68458": ["RHO GTPases activate PKNs"], "68463": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "68465": ["AMPK inhibits chREBP transcriptional activation activity"], "68468": ["Post-translational modification: synthesis of GPI-anchored proteins"], "68472": ["Complex I biogenesis"], "68473": ["Signaling by Hippo"], "68475": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "68479": ["mRNA Splicing - Major Pathway"], "68493": ["Complex I biogenesis"], "68497": ["Antigen processing: Ubiquitination & Proteasome degradation"], "68499": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "68501": ["SUMOylation of DNA damage response and repair proteins"], "68505": ["Retrograde transport at the Trans-Golgi-Network"], "68507": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "68510": ["RNA polymerase II transcribes snRNA genes"], "68514": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "68524": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs"], "68525": ["Hedgehog 'on' state", "Activation of SMO"], "68533": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "68537": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "68549": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "68556": ["Pyrimidine salvage"], "68563": ["Synthesis of dolichyl-phosphate mannose"], "68565": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "68572": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "68576": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "68581": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "68585": ["Axonal growth inhibition (RHOA activation)"], "68591": ["Molybdenum cofactor biosynthesis"], "68592": ["mRNA Splicing - Major Pathway"], "68598": ["mRNA Splicing - Major Pathway"], "68603": ["Cholesterol biosynthesis"], "68611": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "68612": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "68628": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "68631": ["Formation of xylulose-5-phosphate"], "68636": ["Citric acid cycle (TCA cycle)"], "68642": ["Anchoring of the basal body to the plasma membrane"], "68646": ["Nicotinate metabolism"], "68652": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "68667": ["TRP channels"], "68668": ["Formation of the cornified envelope"], "68671": ["Synthesis of PE"], "68673": ["Keratinization"], "68680": ["Lipid particle organization"], "68682": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds", "Neutrophil degranulation"], "68705": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "68713": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "68723": ["Neutrophil degranulation"], "68724": ["Neutrophil degranulation"], "68729": ["Antigen processing: Ubiquitination & Proteasome degradation"], "68732": ["Factors involved in megakaryocyte development and platelet production"], "68735": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "68738": ["Ethanol oxidation"], "68742": ["TP53 Regulates Transcription of Death Receptors and Ligands"], "68744": ["Generic Transcription Pathway"], "68768": ["Keratinization"], "68775": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "68776": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "68794": ["Cell-extracellular matrix interactions"], "68801": ["Linoleic acid (LA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "68813": ["Factors involved in megakaryocyte development and platelet production"], "68816": ["mRNA Splicing - Major Pathway"], "68817": ["Organic cation transport", "Intestinal hexose absorption"], "68836": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "68837": ["UCH proteinases"], "68842": ["Neddylation"], "68854": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "68865": ["Cholesterol biosynthesis"], "68870": ["Interconversion of nucleotide di- and triphosphates"], "68877": ["Regulation of PTEN gene transcription"], "68879": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "68891": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "68911": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "68942": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "68943": ["Pink/Parkin Mediated Mitophagy"], "68947": ["Reactions specific to the complex N-glycan synthesis pathway"], "68953": ["Macroautophagy", "Lysosome Vesicle Biogenesis", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "68961": ["Glycogen breakdown (glycogenolysis)"], "68975": ["Generic Transcription Pathway"], "68979": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "68981": ["mRNA Splicing - Major Pathway"], "68988": ["mRNA Splicing - Major Pathway"], "68991": ["RNA polymerase II transcribes snRNA genes"], "68999": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "69008": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "69010": ["Antigen processing: Ubiquitination & Proteasome degradation"], "69019": ["Synthesis, secretion, and deacylation of Ghrelin"], "69020": ["Generic Transcription Pathway"], "69029": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "69046": ["Mitochondrial iron-sulfur cluster biogenesis"], "69047": ["Ion transport by P-type ATPases"], "69048": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "69051": ["Amino acid synthesis and interconversion (transamination)"], "69060": ["Digestion of dietary lipid", "Retinoid metabolism and transport"], "69064": ["GDP-fucose biosynthesis"], "69065": ["Glutathione synthesis and recycling"], "69072": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "69076": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "69077": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "69083": ["Cytosolic sulfonation of small molecules"], "69089": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "69116": ["Neutrophil degranulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "69117": ["Ethanol oxidation"], "69123": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "69125": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "69131": ["TP53 Regulates Transcription of DNA Repair Genes"], "69146": ["Neutrophil degranulation"], "69162": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "69163": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "69165": ["CD209 (DC-SIGN) signaling", "Butyrophilin (BTN) family interactions"], "69178": ["Golgi Associated Vesicle Biogenesis"], "69181": ["Regulation of TP53 Activity through Phosphorylation"], "69188": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "69192": ["mRNA Splicing - Major Pathway"], "69207": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "69217": ["Synthesis of PIPs at the plasma membrane"], "69219": ["eNOS activation"], "69225": ["Nicotinamide salvaging"], "69228": ["Generic Transcription Pathway"], "69234": ["Generic Transcription Pathway"], "69241": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "69257": ["RUNX1 regulates transcription of genes involved in BCR signaling"], "69260": ["SUMOylation of transcription cofactors", "PI5P Regulates TP53 Acetylation"], "69263": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "69270": ["Unwinding of DNA"], "69276": ["XBP1(S) activates chaperone genes"], "69288": ["Rho GTPase cycle"], "69296": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "69299": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "69305": ["mRNA decay by 3' to 5' exoribonuclease"], "69314": ["Sperm:Oocyte Membrane Binding"], "69332": ["Formation of the cornified envelope"], "69354": ["Amino acid transport across the plasma membrane"], "69363": ["Post-translational modification: synthesis of GPI-anchored proteins"], "69372": ["Molybdenum cofactor biosynthesis"], "69379": ["Terminal pathway of complement", "Regulation of Complement cascade"], "69386": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "69440": ["RAB GEFs exchange GTP for GDP on RABs"], "69456": ["Neddylation"], "69464": ["Keratinization"], "69473": ["Keratinization"], "69482": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "69487": ["Complex I biogenesis"], "69511": ["Formation of the cornified envelope"], "69514": ["Formation of the cornified envelope"], "69520": ["Formation of the cornified envelope"], "69524": ["Cell surface interactions at the vascular wall"], "69527": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "69533": ["Keratinization"], "69537": ["Neutrophil degranulation"], "69543": ["Degradation of the extracellular matrix"], "69550": ["Neutrophil degranulation"], "69562": ["TP53 Regulates Transcription of DNA Repair Genes", "Neutrophil degranulation"], "69564": ["Nicotinate metabolism"], "69573": ["Lipid particle organization"], "69574": ["Phase I - Functionalization of compounds"], "69581": ["Rho GTPase cycle"], "69583": ["HuR (ELAVL1) binds and stabilizes mRNA", "TNFs bind their physiological receptors"], "69590": ["Detoxification of Reactive Oxygen Species"], "69597": ["Processing of SMDT1"], "69601": ["Regulation of RAS by GAPs"], "69608": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "69612": ["HATs acetylate histones"], "69617": ["Mitochondrial protein import"], "69632": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse"], "69639": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "69641": ["Ub-specific processing proteases"], "69654": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "69656": ["Digestion"], "69660": ["Neutrophil degranulation"], "69661": ["Keratinization"], "69664": ["Keratinization"], "69675": ["Crosslinking of collagen fibrils"], "69677": ["Interleukin-36 pathway"], "69696": ["Keratinization"], "69698": ["Vitamin B2 (riboflavin) metabolism"], "69700": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "69702": ["Complex I biogenesis"], "69706": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "69710": ["Rho GTPase cycle", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "69714": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "69718": ["Synthesis of IPs in the nucleus"], "69719": ["Pyrimidine biosynthesis"], "69721": ["RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "69726": ["PKMTs methylate histone lysines"], "69731": ["snRNP Assembly"], "69736": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "69740": ["Synthesis of diphthamide-EEF2"], "69745": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "69754": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "69761": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "69769": ["PI Metabolism"], "69772": ["Synthesis of Ketone Bodies"], "69790": ["Generic Transcription Pathway"], "69792": ["Generic Transcription Pathway"], "69807": ["Regulation of innate immune responses to cytosolic DNA", "Antigen processing: Ubiquitination & Proteasome degradation"], "69823": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "69833": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "69834": ["Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation"], "69847": ["Stimuli-sensing channels"], "69865": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "69870": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "69875": ["Respiratory electron transport", "Complex I biogenesis"], "69878": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "69882": ["RNA polymerase II transcribes snRNA genes"], "69888": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "69906": ["Metabolism of folate and pterines"], "69908": ["RAB geranylgeranylation"], "69912": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "69917": ["RNA polymerase II transcribes snRNA genes"], "69920": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "69922": ["Initiation of Nuclear Envelope Reformation"], "69923": ["Glycerophospholipid biosynthesis"], "69928": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Fanconi Anemia Pathway", "Mitotic Prometaphase"], "69930": ["Generic Transcription Pathway"], "69940": ["Insulin processing", "VxPx cargo-targeting to cilium"], "69956": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "69957": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "69981": ["Neutrophil degranulation"], "69983": ["Digestion of dietary carbohydrate"], "69993": ["Rho GTPase cycle"], "69994": ["Organic cation transport", "Intestinal hexose absorption"], "70008": ["Metabolism of Angiotensinogen to Angiotensins"], "70020": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "70024": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "70025": ["Mitochondrial Fatty Acid Beta-Oxidation"], "70052": ["mRNA Splicing - Major Pathway"], "70059": ["Sphingolipid de novo biosynthesis"], "70061": ["The canonical retinoid cycle in rods (twilight vision)"], "70086": ["Leukotriene receptors", "G alpha (q) signalling events"], "70088": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "70093": ["Antigen processing: Ubiquitination & Proteasome degradation"], "70099": ["Condensation of Prophase Chromosomes", "Condensation of Prometaphase Chromosomes"], "70101": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "70122": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "70129": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "70152": ["Neutrophil degranulation"], "70160": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "70163": ["Post-translational modification: synthesis of GPI-anchored proteins"], "70166": ["Formation of the cornified envelope"], "70202": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "70208": ["Generic Transcription Pathway"], "70218": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "70225": ["mRNA Splicing - Major Pathway"], "70231": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "70233": ["mRNA Splicing - Major Pathway"], "70238": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "70239": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "70247": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "70266": ["Amino acid synthesis and interconversion (transamination)", "Phenylalanine and tyrosine catabolism", "Tryptophan catabolism"], "70294": ["Antigen processing: Ubiquitination & Proteasome degradation"], "70296": ["TBC/RABGAPs"], "70297": ["Retrograde transport at the Trans-Golgi-Network"], "70300": ["Hedgehog 'off' state"], "70315": ["Separation of Sister Chromatids", "HDACs deacetylate histones"], "70316": ["Glyoxylate metabolism and glycine degradation", "Respiratory electron transport", "Complex I biogenesis", "Mitochondrial Fatty Acid Beta-Oxidation"], "70325": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "70333": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "70335": ["Olfactory Signaling Pathway"], "70337": ["Thyroxine biosynthesis"], "70348": ["Antigen processing: Ubiquitination & Proteasome degradation"], "70349": ["Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "70357": ["Phase 1 - inactivation of fast Na+ channels"], "70361": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "70369": ["Regulation of HSF1-mediated heat shock response"], "70377": ["ABC-family proteins mediated transport"], "70383": ["Heme biosynthesis"], "70385": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "70392": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "70408": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "70415": ["Apoptotic cleavage of cellular proteins"], "70422": ["RNA polymerase II transcribes snRNA genes"], "70428": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "70439": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "70450": ["Neutrophil degranulation"], "70465": ["RMTs methylate histone arginines"], "70470": ["RNA polymerase II transcribes snRNA genes"], "70472": ["TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "70484": ["Transport of nucleotide sugars"], "70495": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "70497": ["Rho GTPase cycle"], "70503": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import"], "70511": ["Protein methylation"], "70527": ["Metalloprotease DUBs"], "70530": ["Synaptic adhesion-like molecules"], "70536": ["Neutrophil degranulation"], "70546": ["Surfactant metabolism"], "70568": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "70574": ["Post-translational modification: synthesis of GPI-anchored proteins"], "70579": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "70603": ["Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1"], "70616": ["mRNA Splicing - Major Pathway"], "70620": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "70625": ["Generic Transcription Pathway"], "70640": ["mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "70645": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "70673": ["PKMTs methylate histone lysines"], "70675": ["Ovarian tumor domain proteases"], "70681": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "70683": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "70686": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "70699": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "70701": ["Miscellaneous transport and binding events"], "70719": ["Rho GTPase cycle", "Neutrophil degranulation"], "70727": ["RAF/MAP kinase cascade"], "70737": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "70750": ["Sphingolipid de novo biosynthesis"], "70757": ["Synthesis of very long-chain fatty acyl-CoAs"], "70767": ["mRNA Splicing - Major Pathway"], "70785": ["RAB GEFs exchange GTP for GDP on RABs"], "70789": ["Tryptophan catabolism"], "70799": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "70810": ["Keratinization", "Formation of the cornified envelope"], "70834": ["CDO in myogenesis"], "70839": ["ADP signalling through P2Y purinoceptor 12", "P2Y receptors", "G alpha (i) signalling events"], "70840": ["Organic cation transport"], "70843": ["Keratinization", "Formation of the cornified envelope"], "70861": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "70881": ["Purine catabolism"], "70885": ["RNA polymerase II transcribes snRNA genes"], "70892": ["Carboxyterminal post-translational modifications of tubulin"], "70928": ["Antigen processing: Ubiquitination & Proteasome degradation"], "70945": ["Platelet degranulation "], "70948": ["Ub-specific processing proteases"], "70974": ["Glycogen synthesis", "Glycolysis"], "71003": ["Post-translational modification: synthesis of GPI-anchored proteins"], "71041": ["Transcriptional Regulation by E2F6"], "71063": ["Generic Transcription Pathway"], "71078": ["Interaction With The Zona Pellucida"], "71085": ["Rho GTPase cycle"], "71101": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "71111": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events", "G alpha (s) signalling events"], "71116": ["COPI-dependent Golgi-to-ER retrograde traffic"], "71131": ["Generic Transcription Pathway"], "71169": ["COPI-dependent Golgi-to-ER retrograde traffic"], "71175": ["Cohesin Loading onto Chromatin"], "71177": ["RNA polymerase II transcribes snRNA genes"], "71207": ["Synthesis of pyrophosphates in the cytosol"], "71223": ["G alpha (s) signalling events"], "71240": ["Synthesis of bile acids and bile salts"], "71279": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "71302": ["Rho GTPase cycle"], "71326": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "71336": ["Pentose phosphate pathway"], "71340": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "71345": ["Stimuli-sensing channels"], "71355": ["Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "MET activates PTK2 signaling", "Collagen chain trimerization"], "71365": ["Ubiquinol biosynthesis"], "71367": ["Chondroitin sulfate biosynthesis"], "71371": ["HDMs demethylate histones"], "71382": ["Peroxisomal protein import"], "71393": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "71409": ["RHO GTPases Activate Formins"], "71421": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "71435": ["Rho GTPase cycle"], "71436": ["Downstream signaling of activated FGFR1"], "71453": ["Keratinization"], "71472": ["Ub-specific processing proteases"], "71492": ["BBSome-mediated cargo-targeting to cilium"], "71514": ["PTK6 Regulates Proteins Involved in RNA Processing"], "71517": ["Neutrophil degranulation"], "71519": ["Miscellaneous substrates", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "71520": ["Signaling by SCF-KIT"], "71521": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "71522": ["Aflatoxin activation and detoxification"], "71529": ["Formation of the cornified envelope"], "71538": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "71544": ["Rho GTPase cycle"], "71564": ["Sperm:Oocyte Membrane Binding"], "71586": ["Ub-specific processing proteases"], "71599": ["UCH proteinases", "Neddylation"], "71609": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Dimerization of procaspase-8", "TNF signaling"], "71648": ["Regulation of PLK1 Activity at G2/M Transition", "TBC/RABGAPs"], "71660": ["Platelet degranulation "], "71665": ["Neutrophil degranulation", "Reactions specific to the complex N-glycan synthesis pathway"], "71670": ["Aflatoxin activation and detoxification"], "71679": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "71685": ["O-linked glycosylation of mucins"], "71693": ["Lectin pathway of complement activation", "Initial triggering of complement"], "71702": ["mRNA Splicing - Major Pathway"], "71704": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "71707": ["Metabolism of vitamin K"], "71709": ["Rho GTPase cycle"], "71711": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "71713": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "71720": ["Synthesis of bile acids and bile salts"], "71726": ["Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "71728": ["Neutrophil degranulation"], "71729": ["G alpha (i) signalling events"], "71740": ["Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "71742": ["Hedgehog 'on' state"], "71743": ["Coenzyme A biosynthesis"], "71745": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "71752": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "71753": ["Collagen degradation"], "71754": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "71756": ["Regulation of Complement cascade"], "71760": ["Synthesis of PE"], "71761": ["Histidine catabolism"], "71767": ["Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "71770": ["Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "71773": ["Glucuronidation"], "71778": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "71780": ["Synthesis of IP2, IP, and Ins in the cytosol"], "71782": ["Initiation of Nuclear Envelope Reformation"], "71785": ["Signaling by PDGF"], "71793": ["RNA polymerase II transcribes snRNA genes"], "71797": ["Chondroitin sulfate biosynthesis"], "71803": ["Organic anion transporters"], "71805": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "71819": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Telophase/Cytokinesis", "Kinesins"], "71820": ["Intraflagellar transport"], "71832": ["Citric acid cycle (TCA cycle)"], "71833": ["Neddylation"], "71841": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "71844": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "71853": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "71854": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "71865": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "71869": ["Neutrophil degranulation"], "71876": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "71883": ["Mitochondrial protein import", "Ubiquinol biosynthesis"], "71884": ["Digestion of dietary carbohydrate", "Neutrophil degranulation"], "71885": ["Fanconi Anemia Pathway"], "71888": ["Keratinization", "Formation of the cornified envelope"], "71890": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI"], "71893": ["RHO GTPases Activate NADPH Oxidases"], "71897": ["Post-translational modification: synthesis of GPI-anchored proteins"], "71898": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "71902": ["Neutrophil degranulation", "Neddylation", "Iron uptake and transport"], "71903": ["Phase I - Functionalization of compounds"], "71909": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "71910": ["Role of phospholipids in phagocytosis"], "71911": ["Synthesis of Ketone Bodies"], "71920": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "71934": ["Reversible hydration of carbon dioxide"], "71946": ["Platelet degranulation "], "71949": ["Sphingolipid de novo biosynthesis"], "71951": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Retinoid metabolism and transport"], "71954": ["HDACs deacetylate histones", "Ub-specific processing proteases"], "71955": ["Neutrophil degranulation"], "71957": ["RNA polymerase II transcribes snRNA genes"], "71960": ["RHO GTPases activate PAKs"], "71966": ["RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "71974": ["RMTs methylate histone arginines", "Protein methylation"], "71978": ["Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "71985": ["Mitochondrial Fatty Acid Beta-Oxidation"], "71988": ["Establishment of Sister Chromatid Cohesion"], "71991": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "71999": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "72017": ["Platelet degranulation ", "Erythrocytes take up carbon dioxide and release oxygen"], "72018": ["Receptor Mediated Mitophagy"], "72027": ["Zinc influx into cells by the SLC39 gene family"], "72029": ["Trafficking and processing of endosomal TLR"], "72039": ["Biotin transport and metabolism", "Branched-chain amino acid catabolism"], "72042": ["Neutrophil degranulation"], "72045": ["Cellular hexose transport"], "72047": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "72049": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "72054": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "72061": ["Metabolism of Angiotensinogen to Angiotensins"], "72065": ["Neutrophil degranulation"], "72068": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "72077": ["O-linked glycosylation of mucins"], "72083": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "72084": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "72090": ["Phosphate bond hydrolysis by NTPDase proteins"], "72094": ["Glucuronidation"], "72108": ["Synthesis of PA"], "72119": ["Regulation of TP53 Activity through Phosphorylation", "AURKA Activation by TPX2"], "72121": ["RAB GEFs exchange GTP for GDP on RABs"], "72124": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "72129": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "72135": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "72136": ["Dermatan sulfate biosynthesis"], "72140": ["Anchoring of the basal body to the plasma membrane"], "72141": ["Glycolysis"], "72149": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "72151": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "72155": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "72157": ["Glycogen synthesis", "Neutrophil degranulation"], "72162": ["DEx/H-box helicases activate type I IFN and inflammatory cytokines production "], "72180": ["Generic Transcription Pathway"], "72194": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "72198": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "72230": ["Generic Transcription Pathway"], "72258": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "72267": ["Miscellaneous transport and binding events"], "72269": ["Neutrophil degranulation", "Pyrimidine salvage"], "72290": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "72297": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "72303": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "72306": ["Generic Transcription Pathway"], "72308": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "72318": ["Intra-Golgi traffic"], "72323": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "72345": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "72349": ["ERKs are inactivated"], "72361": ["Phase I - Functionalization of compounds"], "72373": ["Post-translational modification: synthesis of GPI-anchored proteins"], "72399": ["RAF activation", "Negative regulation of MAPK pathway"], "72401": ["Amino acid transport across the plasma membrane"], "72413": ["Ca2+ activated K+ channels"], "72415": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "72421": ["Intraflagellar transport"], "72432": ["Formation of the cornified envelope"], "72433": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "72434": ["Post-translational modification: synthesis of GPI-anchored proteins"], "72440": ["HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "72461": ["Intrinsic Pathway of Fibrin Clot Formation", "Neutrophil degranulation"], "72465": ["SUMOylation of transcription cofactors"], "72469": ["Synthesis of IP3 and IP4 in the cytosol"], "72472": ["Amino acid transport across the plasma membrane"], "72482": ["Mitochondrial Fatty Acid Beta-Oxidation"], "72504": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "72508": ["mTORC1-mediated signalling"], "72512": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA", "STAT6-mediated induction of chemokines", "IRF3-mediated induction of type I IFN", "Neutrophil degranulation"], "72514": ["FGFR2b ligand binding and activation"], "72515": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "72535": ["Ethanol oxidation"], "72536": ["Rho GTPase cycle"], "72542": ["Receptor Mediated Mitophagy"], "72543": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "72544": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "72549": ["Olfactory Signaling Pathway"], "72554": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "72556": ["Generic Transcription Pathway"], "72560": ["Amino acid synthesis and interconversion (transamination)"], "72568": ["G0 and Early G1"], "72569": ["BBSome-mediated cargo-targeting to cilium"], "72584": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "72585": ["Post-translational modification: synthesis of GPI-anchored proteins"], "72587": ["Deadenylation of mRNA"], "72590": ["Cyclin A/B1/B2 associated events during G2/M transition"], "72607": ["Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "72611": ["Generic Transcription Pathway"], "72621": ["Vitamin B5 (pantothenate) metabolism", "Transport of vitamins, nucleosides, and related molecules", "Ion influx/efflux at host-pathogen interface", "Ion transport by P-type ATPases"], "72630": ["Regulation of HSF1-mediated heat shock response"], "72656": ["RNA polymerase II transcribes snRNA genes"], "72662": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "72674": ["AMPK inhibits chREBP transcriptional activation activity"], "72685": ["Clathrin-mediated endocytosis"], "72720": ["Generic Transcription Pathway"], "72723": ["Generic Transcription Pathway"], "72727": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "72739": ["Generic Transcription Pathway"], "72754": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "72772": ["COPI-dependent Golgi-to-ER retrograde traffic"], "72774": ["Cleavage of the damaged pyrimidine ", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "72780": ["Regulation of FZD by ubiquitination"], "72787": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "72805": ["Generic Transcription Pathway"], "72821": ["Phase 0 - rapid depolarisation"], "72825": ["RAB GEFs exchange GTP for GDP on RABs"], "72836": ["DNA Damage/Telomere Stress Induced Senescence"], "72900": ["Respiratory electron transport", "Complex I biogenesis"], "72902": ["Activation of Matrix Metalloproteinases"], "72935": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA"], "72938": ["Intraflagellar transport"], "72947": ["Collagen degradation", "Lysine catabolism"], "72949": ["Formation of RNA Pol II elongation complex ", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "72961": ["Glutamate Neurotransmitter Release Cycle", "Organic anion transporters"], "72962": ["Pyrimidine catabolism"], "72978": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "72993": ["Caspase activation via Dependence Receptors in the absence of ligand"], "73016": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "73046": ["Mitochondrial iron-sulfur cluster biogenesis"], "73075": ["mRNA Splicing - Major Pathway"], "73078": ["Processing of SMDT1"], "73086": ["ERK/MAPK targets", "CREB phosphorylation", "NCAM signaling for neurite out-growth", "CD209 (DC-SIGN) signaling"], "73094": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "73124": ["Intra-Golgi traffic"], "73130": ["WNT ligand biogenesis and trafficking"], "73132": ["Coenzyme A biosynthesis"], "73162": ["Ovarian tumor domain proteases", "Regulation of PTEN stability and activity"], "73166": ["Retrograde transport at the Trans-Golgi-Network"], "73167": ["Rho GTPase cycle"], "73178": ["Regulation of actin dynamics for phagocytic cup formation", "NOSTRIN mediated eNOS trafficking", "Nephrin family interactions", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "73218": ["Regulation of TNFR1 signaling"], "73242": ["Cilium Assembly"], "73251": ["PKMTs methylate histone lysines"], "73296": ["Retrograde transport at the Trans-Golgi-Network"], "73341": ["NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "G beta:gamma signalling through CDC42"], "73368": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "73390": ["HATs acetylate histones"], "73442": ["Regulation of HSF1-mediated heat shock response"], "73456": ["Sperm:Oocyte Membrane Binding"], "73458": ["Sphingolipid de novo biosynthesis"], "73470": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "73473": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "73532": ["Phosphate bond hydrolysis by NUDT proteins"], "73582": ["Inactivation, recovery and regulation of the phototransduction cascade", "Protein methylation"], "73647": ["Degradation of the extracellular matrix"], "73649": ["Iron uptake and transport"], "73666": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "73668": ["Hedgehog 'off' state", "Intraflagellar transport"], "73670": ["Beta defensins", "Defensins"], "73671": ["Cytosolic sulfonation of small molecules"], "73674": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "73677": ["UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "73690": ["Neutrophil degranulation"], "73694": ["Complex I biogenesis"], "73699": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition"], "73710": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "73711": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "73724": ["Propionyl-CoA catabolism"], "73729": ["Generic Transcription Pathway"], "73736": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "73738": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "73739": ["Deactivation of the beta-catenin transactivating complex"], "73744": ["Lysosomal oligosaccharide catabolism"], "73748": ["Amino acid synthesis and interconversion (transamination)"], "73804": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "73826": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "73828": ["Neddylation"], "73830": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "73834": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "73836": ["Transport and synthesis of PAPS", "Transport of nucleotide sugars"], "73902": ["UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "73910": ["Rho GTPase cycle"], "73914": ["Interleukin-1 signaling"], "73916": ["Hedgehog 'off' state", "Intraflagellar transport"], "73998": ["Antigen processing: Ubiquitination & Proteasome degradation"], "74006": ["Apoptotic execution phase"], "74008": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "74011": ["The fatty acid cycling model", "The proton buffering model"], "74012": ["Neutrophil degranulation"], "74015": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "74016": ["PRC2 methylates histones and DNA"], "74018": ["RAB GEFs exchange GTP for GDP on RABs"], "74019": ["Intraflagellar transport"], "74026": ["HATs acetylate histones"], "74030": ["RAB GEFs exchange GTP for GDP on RABs"], "74035": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "74039": ["Neutrophil degranulation"], "74042": ["Condensation of Prophase Chromosomes", "HDMs demethylate histones"], "74043": ["Peroxisomal protein import"], "74051": ["Transferrin endocytosis and recycling"], "74053": ["Trafficking of GluR2-containing AMPA receptors"], "74055": ["Synthesis of IP3 and IP4 in the cytosol"], "74069": ["Platelet degranulation ", "Neutrophil degranulation"], "74080": ["Nicotinate metabolism"], "74091": ["Sialic acid metabolism"], "74096": ["ROS, RNS production in phagocytes", "Sperm Motility And Taxes", "Neutrophil degranulation"], "74104": ["Mitochondrial ABC transporters"], "74106": ["Neddylation"], "74108": ["Deadenylation of mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "74112": ["Ub-specific processing proteases"], "74114": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import"], "74117": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "74120": ["Generic Transcription Pathway"], "74121": ["Beta-oxidation of pristanoyl-CoA"], "74125": ["Neutrophil degranulation"], "74126": ["Hedgehog ligand biogenesis", "ER Quality Control Compartment (ERQC)"], "74127": ["Keratinization", "Formation of the cornified envelope"], "74129": ["Choline catabolism"], "74132": ["Antigen processing: Ubiquitination & Proteasome degradation"], "74134": ["Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions"], "74143": ["Regulation of Apoptosis"], "74145": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation"], "74147": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "74153": ["ISG15 antiviral mechanism", "Termination of translesion DNA synthesis", "Antigen processing: Ubiquitination & Proteasome degradation"], "74154": ["Antigen processing: Ubiquitination & Proteasome degradation"], "74156": ["Mitochondrial Fatty Acid Beta-Oxidation"], "74158": ["Josephin domain DUBs"], "74159": ["Peroxisomal lipid metabolism"], "74165": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "74167": ["Phosphate bond hydrolysis by NUDT proteins"], "74176": ["Formation of the cornified envelope"], "74180": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "74185": ["Glycogen synthesis"], "74191": ["P2Y receptors", "G alpha (i) signalling events"], "74197": ["RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "74198": ["Activated NOTCH1 Transmits Signal to the Nucleus"], "74201": ["Anchoring of the basal body to the plasma membrane"], "74202": ["Cell-extracellular matrix interactions"], "74205": ["Synthesis of very long-chain fatty acyl-CoAs"], "74237": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "74239": ["Activation of SMO"], "74241": ["Chondroitin sulfate biosynthesis"], "74244": ["Macroautophagy", "Neutrophil degranulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "74246": ["Galactose catabolism"], "74251": ["Neddylation"], "74256": ["NOD1/2 Signaling Pathway", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases"], "74268": ["Regulation of the apoptosome activity"], "74270": ["Ub-specific processing proteases"], "74287": ["Neutrophil degranulation"], "74302": ["Macroautophagy", "Synthesis of PIPs at the plasma membrane"], "74316": ["Mitochondrial iron-sulfur cluster biogenesis"], "74320": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "74325": ["Gap junction degradation", "Formation of annular gap junctions", "Lysosome Vesicle Biogenesis", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "74326": ["mRNA Splicing - Major Pathway"], "74334": ["MET activates RAS signaling"], "74335": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "74338": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "74340": ["Bicarbonate transporters"], "74342": ["Neurexins and neuroligins"], "74351": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "74360": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "74370": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "74375": ["Retrograde transport at the Trans-Golgi-Network"], "74386": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "74400": ["Generic Transcription Pathway"], "74410": ["Carboxyterminal post-translational modifications of tubulin"], "74411": ["Cholesterol biosynthesis"], "74412": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "74414": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "74427": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "74438": ["Lysosome Vesicle Biogenesis"], "74442": ["Sphingolipid de novo biosynthesis"], "74446": ["Stimuli-sensing channels"], "74450": ["Coenzyme A biosynthesis"], "74468": ["Interaction With Cumulus Cells"], "74469": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "74470": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "74482": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "74486": ["Acyl chain remodelling of PS"], "74492": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "74493": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "74498": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "74499": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "74519": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "74522": ["Fatty acyl-CoA biosynthesis"], "74549": ["Cohesin Loading onto Chromatin"], "74551": ["Gluconeogenesis"], "74552": ["Miscellaneous transport and binding events"], "74559": ["Synthesis of very long-chain fatty acyl-CoAs"], "74568": ["TRP channels", "RIPK1-mediated regulated necrosis"], "74570": ["Generic Transcription Pathway"], "74571": ["TWIK-related alkaline pH activated K+ channel (TALK)", "Phase 4 - resting membrane potential"], "74577": ["Glycosphingolipid metabolism"], "74591": ["ABC transporters in lipid homeostasis"], "74596": ["Synthesis of PI"], "74600": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "74603": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "74610": ["Mitochondrial ABC transporters"], "74637": ["Pentose phosphate pathway"], "74646": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "74653": ["O-linked glycosylation"], "74682": ["Hedgehog 'off' state", "Intraflagellar transport"], "74711": ["Carboxyterminal post-translational modifications of tubulin"], "74734": ["Rho GTPase cycle"], "74737": ["Cleavage of Growing Transcript in the Termination Region ", "RNA polymerase II transcribes snRNA genes", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "74747": ["TP53 Regulates Metabolic Genes"], "74754": ["Cholesterol biosynthesis via desmosterol"], "74760": ["RAB GEFs exchange GTP for GDP on RABs"], "74761": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "74762": ["Post-translational modification: synthesis of GPI-anchored proteins"], "74764": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "74769": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Synthesis of PIPs at the plasma membrane", "Downstream signal transduction", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL"], "74772": ["Ion transport by P-type ATPases"], "74776": ["Mitochondrial tRNA aminoacylation", "Pyrophosphate hydrolysis"], "74778": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "74781": ["Macroautophagy"], "74915": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "74996": ["Ub-specific processing proteases"], "74998": ["Vasopressin regulates renal water homeostasis via Aquaporins"], "75050": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "75062": ["mRNA Splicing - Major Pathway"], "75137": ["RNA polymerase II transcribes snRNA genes"], "751864": ["Cell surface interactions at the vascular wall", "DAP12 interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "75234": ["Antigen processing: Ubiquitination & Proteasome degradation"], "75273": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "75292": ["Sphingolipid de novo biosynthesis"], "75296": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "75302": ["UCH proteinases"], "75316": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "75320": ["Synthesis of PE"], "75345": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "75387": ["Transcriptional activation of mitochondrial biogenesis"], "75396": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "75398": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "75400": ["Beta defensins", "Defensins"], "75404": ["Rho GTPase cycle"], "75406": ["Respiratory electron transport", "Complex I biogenesis"], "75409": ["Receptor-type tyrosine-protein phosphatases"], "75410": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "75415": ["Rho GTPase cycle"], "75416": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "75430": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6"], "75456": ["5-Phosphoribose 1-diphosphate biosynthesis"], "75465": ["Intraflagellar transport"], "75471": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Transcriptional regulation by small RNAs"], "75475": ["Glutathione synthesis and recycling"], "75497": ["Triglyceride catabolism"], "75510": ["Sperm:Oocyte Membrane Binding"], "75512": ["Detoxification of Reactive Oxygen Species"], "75526": ["Antimicrobial peptides"], "75540": ["GDP-fucose biosynthesis"], "75547": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "75555": ["SUMOylation of DNA damage response and repair proteins"], "75560": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "DNA Damage/Telomere Stress Induced Senescence"], "75586": ["Keratinization"], "75590": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "75597": ["Complex I biogenesis"], "75605": ["HDMs demethylate histones", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "75607": ["Stimuli-sensing channels"], "75608": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "75612": ["Keratan sulfate degradation", "Lysosome Vesicle Biogenesis", "Neutrophil degranulation"], "75613": ["Generic Transcription Pathway"], "75617": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "75624": ["Inactivation, recovery and regulation of the phototransduction cascade"], "75627": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "75660": ["G0 and Early G1"], "75669": ["PI3K Cascade", "Macroautophagy", "Synthesis of PIPs at the early endosome membrane", "Toll Like Receptor 9 (TLR9) Cascade", "RHO GTPases Activate NADPH Oxidases"], "75678": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IPs in the nucleus"], "75686": ["Phosphate bond hydrolysis by NUDT proteins"], "75692": ["Nuclear Receptor transcription pathway"], "75705": ["L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "Translation initiation complex formation", "Ribosomal scanning and start codon recognition"], "75706": ["Keratinization", "Formation of the cornified envelope"], "75717": ["Downregulation of ERBB2 signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "75723": ["Signaling by Hippo"], "75735": ["Coenzyme A biosynthesis"], "75744": ["Neutrophil degranulation"], "75747": ["TP53 Regulates Metabolic Genes"], "75750": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "75761": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "75763": ["Neddylation"], "75764": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "75769": ["Lysosphingolipid and LPA receptors"], "75772": ["Triglyceride catabolism"], "75778": ["PIP3 activates AKT signaling", "Activation of AKT2", "Negative regulation of the PI3K/AKT network", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Mitochondrial Fatty Acid Beta-Oxidation"], "75786": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "75788": ["Signaling by BMP", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Asymmetric localization of PCP proteins", "Hedgehog 'on' state", "Regulation of RUNX3 expression and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "75805": ["Peptide ligand-binding receptors"], "75826": ["SUMO is proteolytically processed"], "75841": ["ER Quality Control Compartment (ERQC)"], "75863": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "75894": ["Purine salvage"], "75901": ["mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "75956": ["mRNA Splicing - Major Pathway"], "75964": ["RAB GEFs exchange GTP for GDP on RABs"], "75974": ["Factors involved in megakaryocyte development and platelet production"], "75985": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "75986": ["Agmatine biosynthesis"], "76025": ["Neutrophil degranulation"], "76044": ["Condensation of Prophase Chromosomes"], "76073": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "76088": ["Factors involved in megakaryocyte development and platelet production"], "76089": ["RAF/MAP kinase cascade"], "76113": ["Events associated with phagocytolytic activity of PMN cells"], "76117": ["Rho GTPase cycle"], "76123": ["G alpha (i) signalling events"], "76130": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "76167": ["mRNA Splicing - Minor Pathway"], "76184": ["ABC transporters in lipid homeostasis"], "76187": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "76192": ["Arachidonate production from DAG"], "76205": ["Pregnenolone biosynthesis"], "76219": ["Synthesis, secretion, and deacylation of Ghrelin"], "76238": ["Glyoxylate metabolism and glycine degradation"], "76246": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "76252": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "76257": ["Amino acid transport across the plasma membrane"], "76260": ["BBSome-mediated cargo-targeting to cilium"], "76263": ["Glutathione conjugation", "Peroxisomal protein import"], "76267": ["alpha-linolenic acid (ALA) metabolism"], "76279": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "76281": ["RHO GTPases Activate Rhotekin and Rhophilins"], "76282": ["Amino acid synthesis and interconversion (transamination)"], "76293": ["Molecules associated with elastic fibres"], "76294": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "76295": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "76299": ["Neutrophil degranulation"], "76303": ["Sphingolipid de novo biosynthesis", "Synthesis of bile acids and bile salts"], "76308": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "76332": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "76338": ["RAB geranylgeranylation"], "76367": ["Regulation of TP53 Activity through Phosphorylation"], "76375": ["Antigen processing: Ubiquitination & Proteasome degradation"], "76376": ["Sodium/Calcium exchangers"], "76399": ["IL-6-type cytokine receptor ligand interactions"], "76400": ["MAP2K and MAPK activation", "Negative regulation of MAPK pathway"], "76408": ["Recycling of bile acids and salts", "ABC-family proteins mediated transport"], "76411": ["Intraflagellar transport"], "76429": ["Purine ribonucleoside monophosphate biosynthesis"], "76444": ["Keratinization"], "76453": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "76454": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "76459": ["Reversible hydration of carbon dioxide"], "76467": ["Protein repair"], "76477": ["Collagen biosynthesis and modifying enzymes"], "76478": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "76479": ["mRNA Splicing - Major Pathway"], "76483": ["Assembly of active LPL and LIPC lipase complexes"], "76486": ["Post-translational modification: synthesis of GPI-anchored proteins"], "76491": ["Cytosolic sulfonation of small molecules"], "76499": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "76500": ["Synthesis of IPs in the nucleus"], "76501": ["Neutrophil degranulation", "Neddylation"], "76507": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "76509": ["Post-translational modification: synthesis of GPI-anchored proteins"], "76510": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "76522": ["mRNA Splicing - Major Pathway"], "76527": ["Other interleukin signaling"], "76560": ["Formation of the cornified envelope"], "76568": ["Intraflagellar transport"], "76574": ["Synthesis of PC"], "76577": ["Neutrophil degranulation"], "76580": ["Antigen processing: Ubiquitination & Proteasome degradation"], "76608": ["Antigen processing: Ubiquitination & Proteasome degradation"], "76630": ["Metalloprotease DUBs"], "76654": ["Pyrimidine salvage"], "76686": ["Regulation of TNFR1 signaling"], "76688": ["Retrograde transport at the Trans-Golgi-Network"], "76703": ["Metabolism of Angiotensinogen to Angiotensins"], "76707": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "76709": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "76718": ["Sperm Motility And Taxes"], "76719": ["HATs acetylate histones"], "76722": ["Creatine metabolism"], "76757": ["Stimuli-sensing channels", "Ion homeostasis"], "76763": ["Neutrophil degranulation"], "76768": ["Synthesis of PA", "Post-translational modification: synthesis of GPI-anchored proteins", "Intra-Golgi traffic", "Digestion"], "76770": ["Formation of the cornified envelope"], "76779": ["Intraflagellar transport"], "76787": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "76789": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "76800": ["Ub-specific processing proteases"], "76804": ["HDMs demethylate histones", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "76816": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "76826": ["Complex I biogenesis"], "76829": ["RET signaling"], "76843": ["Recognition of DNA damage by PCNA-containing replication complex", "Neddylation"], "76846": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "76850": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs"], "76854": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "76856": ["Sperm Motility And Taxes"], "76857": ["Hedgehog 'on' state"], "76863": ["Neddylation"], "76877": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "76884": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "76890": ["ERBB2 Regulates Cell Motility"], "76893": ["Sphingolipid de novo biosynthesis"], "76895": ["COPI-independent Golgi-to-ER retrograde traffic"], "76898": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "76899": ["Retrograde transport at the Trans-Golgi-Network"], "76901": ["HATs acetylate histones"], "76905": ["Neutrophil degranulation"], "76916": ["Complex I biogenesis"], "76932": ["Retrograde transport at the Trans-Golgi-Network"], "76936": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway"], "76938": ["mRNA Splicing - Major Pathway"], "76942": ["Post-translational modification: synthesis of GPI-anchored proteins"], "76947": ["Complex I biogenesis"], "76952": ["Abacavir metabolism", "Purine catabolism"], "76954": ["RAB GEFs exchange GTP for GDP on RABs"], "76959": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "76965": ["Receptor-type tyrosine-protein phosphatases"], "76969": ["Keratan sulfate biosynthesis"], "76971": ["Cytosolic sulfonation of small molecules"], "76976": ["Synthesis, secretion, and deacylation of Ghrelin"], "76983": ["COPII-mediated vesicle transport"], "76998": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "77018": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "77031": ["Sodium/Proton exchangers"], "77035": ["HDMs demethylate histones"], "77038": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "77040": ["Macroautophagy"], "77041": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "77044": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "77048": ["Anchoring of the basal body to the plasma membrane"], "77055": ["Keratinization", "Formation of the cornified envelope"], "77057": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "77065": ["RNA polymerase II transcribes snRNA genes"], "77113": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "77116": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "77125": ["PIP3 activates AKT signaling", "Ub-specific processing proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-33 signaling"], "77128": ["CREB3 factors activate genes"], "77134": ["mRNA Splicing - Major Pathway"], "77337": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "77371": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "77397": ["Neutrophil degranulation", "Antimicrobial peptides"], "77407": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "77411": ["FGFR2 alternative splicing"], "77480": ["ARMS-mediated activation"], "77519": ["Generic Transcription Pathway"], "77559": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "77578": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "77582": ["Acyl chain remodelling of PI"], "77583": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Release of Hh-Np from the secreting cell", "Post-translational protein phosphorylation"], "77590": ["Chondroitin sulfate biosynthesis"], "77593": ["Formation of Incision Complex in GG-NER"], "77605": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "77626": ["Glycosphingolipid metabolism"], "77634": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "77669": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "77673": ["Beta defensins", "Defensins"], "77674": ["Beta defensins", "Defensins"], "77683": ["Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation", "Transcriptional Regulation by E2F6"], "77697": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "77701": ["Transport of fatty acids"], "77704": ["Transport of fatty acids"], "77706": ["ABC-family proteins mediated transport"], "77721": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "77739": ["O-glycosylation of TSR domain-containing proteins"], "77744": ["Regulation of PLK1 Activity at G2/M Transition"], "77777": ["Post-translational modification: synthesis of GPI-anchored proteins", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "77782": ["HDR through MMEJ (alt-NHEJ)"], "77794": ["O-glycosylation of TSR domain-containing proteins"], "77805": ["Establishment of Sister Chromatid Cohesion"], "77827": ["Generic Transcription Pathway"], "77853": ["HATs acetylate histones"], "77891": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "77929": ["Golgi Associated Vesicle Biogenesis"], "77974": ["The canonical retinoid cycle in rods (twilight vision)"], "77976": ["Regulation of TP53 Activity through Phosphorylation"], "77980": ["Synthesis of PIPs at the ER membrane", "RAB GEFs exchange GTP for GDP on RABs"], "78038": ["Biotin transport and metabolism", "Branched-chain amino acid catabolism"], "78134": ["G alpha (q) signalling events", "P2Y receptors"], "78177": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "78232": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "78245": ["Mitochondrial Fatty Acid Beta-Oxidation"], "78287": ["Toll Like Receptor 9 (TLR9) Cascade", "Factors involved in megakaryocyte development and platelet production"], "78309": ["Neddylation"], "78330": ["Respiratory electron transport", "Complex I biogenesis"], "78339": ["Stimuli-sensing channels"], "78369": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "78372": ["mRNA Splicing - Minor Pathway"], "78382": ["Formation of the cornified envelope"], "78388": ["Neutrophil degranulation"], "78390": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA"], "78394": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "78405": ["Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through FRS2 and FRS3"], "78416": ["Antimicrobial peptides"], "78506": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "78514": ["Rho GTPase cycle"], "78523": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "78541": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "78610": ["Macroautophagy"], "78651": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "78655": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "78658": ["Condensation of Prophase Chromosomes"], "78752": ["Chondroitin sulfate biosynthesis"], "78753": ["Formation of the cornified envelope"], "78754": ["O-linked glycosylation of mucins"], "78757": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "78783": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "78801": ["Interconversion of nucleotide di- and triphosphates"], "78802": ["Intraflagellar transport"], "78816": ["Rho GTPase cycle"], "78826": ["G alpha (q) signalling events", "P2Y receptors"], "78830": ["Gluconeogenesis"], "78833": ["Unwinding of DNA"], "78887": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "78889": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "78892": ["Neutrophil degranulation"], "78893": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "78894": ["Synthesis of Ketone Bodies"], "78910": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "78913": ["Antigen processing: Ubiquitination & Proteasome degradation"], "78914": ["Nicotinate metabolism"], "78920": ["Glyoxylate metabolism and glycine degradation", "Lysine catabolism"], "78921": ["Generic Transcription Pathway"], "78923": ["Chondroitin sulfate biosynthesis"], "78925": ["Androgen biosynthesis"], "78928": ["Attachment of GPI anchor to uPAR"], "78929": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "78943": ["IRE1alpha activates chaperones"], "79043": ["Neddylation"], "79044": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "79059": ["Interconversion of nucleotide di- and triphosphates"], "791260": ["Enzymatic degradation of dopamine by COMT"], "79196": ["Acyl chain remodelling of PS"], "79235": ["Retinoid metabolism and transport"], "79263": ["Antigen processing: Ubiquitination & Proteasome degradation"], "79459": ["Platelet degranulation ", "Neutrophil degranulation", "Gluconeogenesis"], "79464": ["Glyoxylate metabolism and glycine degradation"], "79554": ["Glycosphingolipid metabolism"], "80285": ["Nicotinamide salvaging"], "80286": ["Miscellaneous transport and binding events"], "80287": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "80288": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "80294": ["O-glycosylation of TSR domain-containing proteins"], "80297": ["NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "80334": ["Phase 1 - inactivation of fast Na+ channels"], "80509": ["Generic Transcription Pathway"], "80706": ["Olfactory Signaling Pathway"], "80707": ["Nuclear signaling by ERBB4", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "80708": ["Clathrin-mediated endocytosis"], "80718": ["Platelet degranulation ", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "80721": ["Vitamin B1 (thiamin) metabolism"], "80744": ["mRNA Splicing - Major Pathway"], "80749": ["Synaptic adhesion-like molecules"], "80751": ["Regulation of TP53 Degradation", "Antigen processing: Ubiquitination & Proteasome degradation"], "80752": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "80796": ["Neutrophil degranulation"], "80837": ["Rho GTPase cycle"], "80838": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "80857": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "80860": ["Neutrophil degranulation"], "80876": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "80879": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "80883": ["Post-translational modification: synthesis of GPI-anchored proteins"], "80884": ["Platelet degranulation "], "80885": ["Hydroxycarboxylic acid-binding receptors", "Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "80886": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "80888": ["HSF1-dependent transactivation"], "80898": ["Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "80901": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "80902": ["Generic Transcription Pathway"], "80903": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "80905": ["Translesion Synthesis by POLH", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)"], "80906": ["Phase 1 - inactivation of fast Na+ channels"], "80910": ["G alpha (s) signalling events", "Neutrophil degranulation"], "80911": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import"], "80912": ["Golgi Associated Vesicle Biogenesis"], "80914": ["Pyrimidine salvage"], "80982": ["Hyaluronan biosynthesis and export"], "80987": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs"], "81004": ["HDACs deacetylate histones", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "81018": ["Antigen processing: Ubiquitination & Proteasome degradation"], "81489": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "MAPK6/MAPK4 signaling"], "81535": ["Sphingolipid de novo biosynthesis"], "81600": ["Digestion of dietary carbohydrate"], "81601": ["Formation of the beta-catenin:TCF transactivating complex", "DNA Damage/Telomere Stress Induced Senescence", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "G2/M DNA damage checkpoint", "Estrogen-dependent gene expression"], "81877": ["ECM proteoglycans"], "81896": ["Hedgehog 'off' state", "Intraflagellar transport"], "81897": ["PI3K Cascade", "Trafficking and processing of endosomal TLR", "Toll Like Receptor 9 (TLR9) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "81898": ["B-WICH complex positively regulates rRNA expression", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "81904": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "83379": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "83382": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "83398": ["HS-GAG biosynthesis"], "83409": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "MAP2K and MAPK activation", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "83410": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "83428": ["Class B/2 (Secretin family receptors)"], "83429": ["Transport of inorganic cations/anions and amino acids/oligopeptides", "Miscellaneous transport and binding events"], "83430": ["Interleukin-23 signaling"], "83431": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "83433": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "Other semaphorin interactions"], "83435": ["Synthesis of PIPs at the plasma membrane"], "83453": ["Signaling by BMP", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "83454": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "83486": ["mRNA Splicing - Major Pathway"], "83490": ["PIP3 activates AKT signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "83493": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the Golgi membrane"], "83554": ["Antagonism of Activin by Follistatin", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "83563": ["Ub-specific processing proteases"], "83564": ["Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "83602": ["RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "Estrogen-dependent gene expression"], "83701": ["RNA polymerase II transcribes snRNA genes", "mRNA Splicing - Major Pathway"], "83702": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "83766": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "83767": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "83768": ["Neutrophil degranulation"], "83770": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "83771": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "83796": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "83797": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "83814": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Stimuli-sensing channels", "Antigen processing: Ubiquitination & Proteasome degradation"], "83815": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "83885": ["Urea cycle"], "83922": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "83961": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "83962": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "83964": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions"], "83996": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Basigin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "84035": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "84036": ["Ca2+ activated K+ channels"], "84092": ["Downregulation of ERBB2:ERBB3 signaling", "Regulation of FZD by ubiquitination", "Ub-specific processing proteases"], "84095": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane"], "84112": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "84505": ["PKMTs methylate histone lysines"], "84544": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "84585": ["Ub-specific processing proteases", "Antigen processing: Ubiquitination & Proteasome degradation"], "85030": ["TNFs bind their physiological receptors"], "85031": ["Acyl chain remodelling of PS"], "89867": ["COPII-mediated vesicle transport"], "93671": ["Scavenging of heme from plasma"], "93672": ["Interleukin-20 family signaling"], "93681": ["Generic Transcription Pathway"], "93685": ["Phosphate bond hydrolysis by NTPDase proteins"], "93686": ["FGFR2 alternative splicing"], "93687": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "GLI3 is processed to GLI3R by the proteasome", "Activation of SMO"], "93689": ["Smooth Muscle Contraction"], "93690": ["G alpha (s) signalling events"], "93692": ["Interconversion of nucleotide di- and triphosphates"], "93695": ["PTK6 promotes HIF1A stabilization"], "93697": ["RNA polymerase II transcribes snRNA genes"], "93719": ["Neutrophil degranulation", "Antimicrobial peptides"], "93721": ["Regulation of Complement cascade"], "93725": ["Neutrophil degranulation", "Antimicrobial peptides"], "93726": ["Neutrophil degranulation", "Antimicrobial peptides"], "93730": ["BBSome-mediated cargo-targeting to cilium"], "93732": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import"], "93735": ["WNT ligand biogenesis and trafficking"], "93736": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "93737": ["Tight junction interactions"], "93739": ["Macroautophagy", "TBC/RABGAPs"], "93742": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions"], "93747": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "93759": ["Regulation of HSF1-mediated heat shock response", "SIRT1 negatively regulates rRNA expression", "Regulation of FOXO transcriptional activity by acetylation"], "93760": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "93762": ["B-WICH complex positively regulates rRNA expression", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "93765": ["ISG15 antiviral mechanism", "NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "CLEC7A (Dectin-1) signaling", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "E3 ubiquitin ligases ubiquitinate target proteins", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "93790": ["Miscellaneous transport and binding events"], "93834": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "93835": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "HDL clearance"], "93836": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Formation of Incision Complex in GG-NER", "Antigen processing: Ubiquitination & Proteasome degradation"], "93841": ["UCH proteinases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Neddylation"], "93871": ["Interleukin-7 signaling", "Chromatin modifying enzymes"], "93896": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "93898": ["Sphingolipid de novo biosynthesis"], "94045": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "94060": ["Formation of the cornified envelope"], "94061": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "94062": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "94063": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "94064": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "94065": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "94066": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "94067": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "94090": ["Antigen processing: Ubiquitination & Proteasome degradation"], "94091": ["Antigen processing: Ubiquitination & Proteasome degradation"], "94093": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "94111": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "94112": ["Generic Transcription Pathway"], "94175": ["Platelet degranulation ", "Dissolution of Fibrin Clot"], "94176": ["Neutrophil degranulation", "Factors involved in megakaryocyte development and platelet production"], "94178": ["TRP channels", "Transferrin endocytosis and recycling"], "94179": ["Keratinization", "Formation of the cornified envelope"], "94180": ["Synthesis of very long-chain fatty acyl-CoAs"], "94181": ["Sialic acid metabolism"], "94190": ["Rho GTPase cycle"], "94192": ["O-linked glycosylation of mucins"], "94212": ["GAB1 signalosome", "Phosphorylation of CD3 and TCR zeta chains"], "94215": ["Glucuronidation"], "94216": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Non-integrin membrane-ECM interactions", "Collagen chain trimerization"], "94221": ["RHO GTPases regulate CFTR trafficking"], "94224": ["Androgen biosynthesis"], "94226": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "94229": ["Bicarbonate transporters"], "94230": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "94245": ["Golgi Associated Vesicle Biogenesis"], "94246": ["HDACs deacetylate histones"], "94253": ["Degradation of DVL"], "94284": ["Glucuronidation"], "94315": ["mRNA Splicing - Major Pathway"], "94332": ["Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "94352": ["Crosslinking of collagen fibrils"], "96979": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Neutrophil degranulation"], "97064": ["Signaling by Hippo", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "97086": ["Stimuli-sensing channels"], "97114": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "97122": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "97165": ["Activation of DNA fragmentation factor"], "97212": ["Acyl chain remodeling of CL", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "97287": ["Macroautophagy", "Synthesis of PIPs at the plasma membrane"], "97440": ["O-linked glycosylation of mucins"], "97484": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "97848": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "97884": ["O-linked glycosylation"], "97895": ["Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "97908": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "98053": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "98170": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "98193": ["Neddylation"], "98221": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition"], "98256": ["Tryptophan catabolism"], "98314": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "98386": ["Cholesterol biosynthesis", "Regulation of MECP2 expression and activity"], "98388": ["Reactions specific to the complex N-glycan synthesis pathway"], "98396": ["Metal ion SLC transporters"], "98432": ["Negative regulation of the PI3K/AKT network"], "98488": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "98660": ["Ion homeostasis", "Ion transport by P-type ATPases"], "98711": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "98732": ["COPI-independent Golgi-to-ER retrograde traffic", "RAB GEFs exchange GTP for GDP on RABs"], "98733": ["Neddylation"], "98741": ["Voltage gated Potassium channels"], "98758": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway"], "98766": ["Antigen processing: Ubiquitination & Proteasome degradation"], "98910": ["Retrograde transport at the Trans-Golgi-Network"], "98985": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "99010": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG", "Synthesis of PA"], "99011": ["O-linked glycosylation"], "99031": ["Synthesis of bile acids and bile salts"], "99045": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "99100": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "99138": ["Synthesis of PC"], "99152": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "99296": ["Histamine receptors", "G alpha (i) signalling events"], "99311": ["Neddylation"], "99375": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "99377": ["Regulation of PTEN gene transcription"], "99412": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "99439": ["Thyroxine biosynthesis"], "99571": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Regulation of TLR by endogenous ligand", "Post-translational protein phosphorylation"], "99586": ["Pyrimidine catabolism"], "99663": ["Stimuli-sensing channels"], "99681": ["Formation of the cornified envelope"], "99683": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "99709": ["Stimuli-sensing channels"], "99712": ["Synthesis of PC", "Synthesis of PE"], "99730": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "99738": ["Voltage gated Potassium channels"], "99890": ["RMTs methylate histone arginines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "99982": ["HDACs deacetylate histones", "HDMs demethylate histones", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"]}}