annotate test-data/hcv_rules.1.8.yaml @ 4:27d61a7f82f1 draft default tip

"planemo upload for repository https://github.com/public-health-bioinformatics/galaxy_tools/blob/master/tools/micall-lite commit e58e1a02d64c2771fadf006bdf8f3661d069b6f3"

- code: ASV
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS3
    region: NS3
    rules: SCORE FROM ( V36GLM => 4, V36!AGLMV => "Effect unknown", T54S => 4,
       V55A => 4, Q80KLR => 4, Q80!KLQR => "Effect unknown", S122GINT => 4,
       S122!GINRST => "Effect unknown", R155GQ => 4, R155K => 8,
       R155!GKQR => "Effect unknown", A156!A => "Effect unknown", D168AEGVY => 8,
       D168FHNT => 4, D168CIKLMPQRSW => "Effect unknown", I170T => 4 )
  - genotype: 1B
    reference: HCV1B-Con1-NS3
    region: NS3
    rules: SCORE FROM ( V36GM => 4, V36!AGLMV => "Effect unknown", T54S => 4,
       Y56HL => 4, Y56!HLY => "Effect unknown", N77S => 4, Q80K => 8, Q80LR => 4,
       Q80!KLQR => "Effect unknown", S122DGINT => 4,
       S122!DGINST => "Effect unknown", R155GQ => 4, R155K => 8,
       R155!GKQR => "Effect unknown", A156ST => 4, A156V => 8,
       A156!ASTV => "Effect unknown", D168ACEGHVY => 8, D168FNT => 4,
       D168IKLMPQRSW => "Effect unknown", V170A => 4 )
  - genotype: '2'
    reference: HCV2-JFH-1-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '3'
    reference: HCV3-S52-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '4'
    reference: HCV4-ED43-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '5'
    reference: HCV5-SA13-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  name: Asunaprevir
- code: DCV
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS5a
    region: NS5a
    rules: SCORE FROM ( K24R => 4, K24T => 8, M28AGT => 8, M28V => 4,
       M28!AGILMTV => "Effect unknown", Q30DEGHKNRY => 8, Q30T => 4,
       Q30AFMSW => "Effect unknown", L31IMV => 8, L31!ILMV => "Effect unknown",
       P32L => 8, P32!LP => "Effect unknown", H54RY => 4,
       H54!CHNRY => "Effect unknown", H58D => 8, H58PV => 4,
       H58AEFGIKMTW => "Effect unknown", A92K => 8, A92P => 4,
       A92!AKPTV => "Effect unknown", Y93CHNST => 8, Y93FR => 4,
       Y93!CFHNRSTY => "Effect unknown" )
  - genotype: 1B
    reference: HCV1B-Con1-NS5a
    region: NS5a
    rules: SCORE FROM ( L28AMT => 4, L28!AILMTV => "Effect unknown", P29S => 4,
       P29d => 8, R30G => 8, R30HKQ => 4, R30!GHKLPQRST => "Effect unknown",
       L31FIMW => 4, L31V => 8, L31!FILMVW => "Effect unknown", P32d => 8,
       P32!LP => "Effect unknown", Q54H => 4, P58LS => 4, Q62E => 4, A92E => 4,
       A92K => 8, A92!AEKPTV => "Effect unknown", Y93H => 8, Y93N => 4,
       Y93!CFHLNY => "Effect unknown" )
  - genotype: '2'
    reference: HCV2-JFH-1-NS5a
    region: NS5a
    rules: SCORE FROM ( F28CS => 8, F28!CFILS => "Effect unknown", L31M => 8,
       L31!LM => "Effect unknown", C92R => 8, C92!CR => "Effect unknown",
       Y93H => 8, Y93!HY => "Effect unknown" )
  - genotype: '3'
    reference: HCV3-S52-NS5a
    region: NS5a
    rules: SCORE FROM ( M28K => 8, M28T => 4, M28!IKMTV => "Effect unknown",
       A30EK => 8, A30SV => 4, A30!AEKRSTV => "Effect unknown", L31FIMV => 8,
       L31P => 4, L31!FILMPV => "Effect unknown", P58H => 4, S62AILPRT => 4,
       S62CEFGHMVWY => "Effect unknown", E92G => 4, Y93H => 8,
       Y93!HY => "Effect unknown" )
  - genotype: '4'
    reference: HCV4-ED43-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '5'
    reference: HCV5-SA13-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  name: Daclatasvir
- code: DAS
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS5b
    region: NS5b
    rules: SCORE FROM ( G307R => 4, L314H => 8, L314!HL => "Effect unknown",
       C316Y => 8, C316!CY => "Effect unknown", A395G => 8,
       A395!AG => "Effect unknown", M414ITV => 8, M414!IMTV => "Effect unknown",
       N444K => 8, N444!KN => "Effect unknown", E446KQ => 8,
       E446!EKQ => "Effect unknown", Y448CH => 8, Y448!CHY => "Effect unknown",
       A450V => 4, A553I => 4, A553TV => 8, A553!AITV => "Effect unknown",
       G554S => 8, G554!DGS => "Effect unknown", S556GR => 8,
       S556!GRS => "Effect unknown", G558R => 4, D559GINV => 4,
       D559!DGINV => "Effect unknown", Y561H => 8, Y561!HY => "Effect unknown",
       L588F => 4 )
  - genotype: 1B
    reference: HCV1B-Con1-NS5b
    region: NS5b
    rules: SCORE FROM ( C316HNY => 8, C316!CHNY => "Effect unknown", S368T => 8,
       A395!A => "Effect unknown", N411S => 8, M414ITV => 8,
       M414!IMTV => "Effect unknown", D444!D => "Effect unknown", C445F => 4,
       Y448CH => 8, Y448!CHY => "Effect unknown", A553V => 8,
       A553!AV => "Effect unknown", S556G => 8, S556R => 4,
       S556!GRS => "Effect unknown", D559G => 8, D559!DG => "Effect unknown" )
  - genotype: '2'
    reference: HCV2-JFH-1-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '3'
    reference: HCV3-S52-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '4'
    reference: HCV4-ED43-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '5'
    reference: HCV5-SA13-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  name: Dasabuvir
- code: EBV
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS5a
    region: NS5a
    rules: SCORE FROM ( K24R => 4, M28AGT => 8, M28V => 4,
       M28!AGMTV => "Effect unknown", Q30DEGHKR => 8, Q30LY => 4,
       Q30!DEGHKLQRY => "Effect unknown", L31FIMV => 8,
       L31!FILMV => "Effect unknown", H58D => 8, H58!DH => "Effect unknown",
       E62D => 4, Y93CHN => 8, Y93S => 4, Y93!CFHNSY => "Effect unknown",
       D427N => 4 )
  - genotype: 1B
    reference: HCV1B-Con1-NS5a
    region: NS5a
    rules: SCORE FROM ( L28M => 4, R30Q => 8, L31FMV => 8,
       L31!FLMV => "Effect unknown", P58S => 4, Y93H => 8,
       Y93!CHY => "Effect unknown" )
  - genotype: '2'
    reference: HCV2-JFH-1-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '3'
    reference: HCV3-S52-NS5a
    region: NS5a
    rules: SCORE FROM ( A30DK => 8, A30!ADK => "Effect unknown", L31FM => 8,
       L31!FLM => "Effect unknown", P58S => 4, P58!PS => "Effect unknown",
       S62APT => 4, S62!APST => "Effect unknown", Y93H => 8,
       Y93!HY => "Effect unknown" )
  - genotype: '4'
    reference: HCV4-ED43-NS5a
    region: NS5a
    rules: SCORE FROM ( L28MST => 4, L30FH => 8, L30RS => 4,
       L30!FHLPRS => "Effect unknown", M31I => 4, M31V => 8,
       M31!IMV => "Effect unknown", P32L => 4, H54Y => 4, P58D => 8, P58TY => 4,
       P58!DPTY => "Effect unknown", Y93C => 4, Y93H => 8,
       Y93!CHY => "Effect unknown" )
  - genotype: '5'
    reference: HCV5-SA13-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  name: Elbasvir
- code: GLP
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS3
    region: NS3
    rules: SCORE FROM ( V36AFM => 4, V36!AFLMV => "Effect unknown", V55AI => 4,
       V55!AIV => "Effect unknown", Y56H => 4, Q80KL => 4,
       Q80!KLQR => "Effect unknown", I132V => 4, R155KT => 4,
       R155!KMRSTV => "Effect unknown", A156GV => 4, A156T => 8,
       A156!AGTV => "Effect unknown", D168AFY => 8, D168EHTV => 4,
       D168!ADEFHNTVY => "Effect unknown" )
  - genotype: 1B
    reference: HCV1B-Con1-NS3
    region: NS3
    rules: SCORE FROM ( Y56F => 4, A156TV => 8, A156!ASTV => "Effect unknown",
       D168FTV => 4, D168K => 8, D168!ADEFHKTVY => "Effect unknown", E176G => 4 )
  - genotype: '2'
    reference: HCV2-JFH-1-NS3
    region: NS3
    rules: SCORE FROM ( I132L => 4, A156MTV => 8, A156!AMTV => "Effect unknown",
       D168EFHT => 4, D168!ADEFHSTVY => "Effect unknown" )
  - genotype: '3'
    reference: HCV3-S52-NS3
    region: NS3
    rules: SCORE FROM ( T54S => 4, Y56HN => 4, Y56!HNY => "Effect unknown",
       Q80KR => 8, Q80!KQR => "Effect unknown", V107I => 4, L132I => 4,
       A156G => 8, A156!AG => "Effect unknown", A166T => 8, A166SY => 4,
       A166!ASTY => "Effect unknown", Q168K => 4, Q168LR => 8,
       Q168!HKLQR => "Effect unknown", D186LR => 4, D186!DLR => "Effect unknown",
       I366V => 4 )
  - genotype: '4'
    reference: HCV4-ED43-NS3
    region: NS3
    rules: SCORE FROM ( Y56H => 4, G90R => 4, R155C => 4, A156TV => 8,
       A156!ATV => "Effect unknown", D168H => 8, D168V => 4,
       D168!DHV => "Effect unknown" )
  - genotype: '5'
    reference: HCV5-SA13-NS3
    region: NS3
    rules: SCORE FROM ( A156!A => "Effect unknown", D168E => 4,
       D168!DE => "Effect unknown" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS3
    region: NS3
    rules: SCORE FROM ( L80R => 8, L80!LR => "Effect unknown",
       A156M => 4, A156!AM => "Effect unknown", D168AGHVY => 8,
       D168!ADGHVY => "Effect unknown" )
  name: Glecaprevir
- code: GZR
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS3
    region: NS3
    rules: SCORE FROM ( V36ALM => 4, V36!AILMV => "Effect unknown", Q41R => 4,
       I48V => 4, V55A => 4, Y56F => 4, Y56H => 8, Y56!FHY => "Effect unknown",
       Q80KL => 8, Q80S => 4, Q80!KLQRS => "Effect unknown", V107I => 4,
       S122GT => 4, S122!AGRST => "Effect unknown", I132V => 4, R155GIS => 4,
       R155KQTW => 8, R155!GIKQRSTW => "Effect unknown", A156GLTV => 8,
       A156!AGLSTV => "Effect unknown", V158A => 4, D168!CDMPQRSW => 8,
       D168C => 4, D168MPQRW => "Effect unknown", I170V => 4, T185S => 4,
       E357GK => 4 )
  - genotype: 1B
    reference: HCV1B-Con1-NS3
    region: NS3
    rules: SCORE FROM ( T54S => 4, Y56H => 8, Y56F => 4,
       Y56!FHY => "Effect unknown", Q80L => 4, V107I => 4, S122NRT => 4,
       S122!AGNRST => "Effect unknown", V132IL => 4, V132!ILV => "Effect unknown",
       R155GTW => 8, R155Q => 4, R155!EGKNQRSTW => "Effect unknown", A156TV => 8,
       A156!AGSTV => "Effect unknown", D168AEFGHIKLTV => 8, D168NY => 4,
       D168CMPQRW => "Effect unknown", V170I => 4, T185S => 4, E357K => 4 )
  - genotype: '2'
    reference: HCV2-JFH-1-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '3'
    reference: HCV3-S52-NS3
    region: NS3
    rules: SCORE FROM ( Y56H => 4, A156TV => 8, A156!ATV => "Effect unknown",
       Q168!HQR => "Effect unknown", Q178R => 4 )
  - genotype: '4'
    reference: HCV4-ED43-NS3
    region: NS3
    rules: SCORE FROM ( V107I => 4, A156MTV => 4, A156!AMTV => "Effect unknown",
       D168AV => 8, D168EG => 4, D168!ADEGV => "Effect unknown", V170I => 4 )
  - genotype: '5'
    reference: HCV5-SA13-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS3
    region: NS3
    rules: SCORE FROM ( V36IL => 4, V36!ILV => "Effect unknown", Y56H => 4,
       L80KQ => 4, L80!KLQ => "Effect unknown", I132L => 4, A156MTV => 4,
       A156!AMTV => "Effect unknown", D168CEY => 4, D168!CDEY => "Effect unknown",
       I170V => 4 )
  name: Grazoprevir
- code: LDV
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS5a
    region: NS5a
    rules: SCORE FROM ( K24R => 4, M28AGT => 8, M28V => 4,
       M28!AGILMTV => "Effect unknown", Q30EGHKNRY => 8, Q30LT => 4,
       Q30ADFMPSW => "Effect unknown", L31IMV => 8, L31P => 4,
       L31!ILMPV => "Effect unknown", P32L => 8, P32!LP => "Effect unknown",
       S38F => 8, S38!FST => "Effect unknown", H58D => 8, H58PR => 4,
       H58!CDHPQRY => "Effect unknown", A92K => 8, A92!AKPTV => "Effect unknown",
       Y93CHLNRSTW => 8, Y93F => 4, Y93ADEGIKMPQV => "Effect unknown" )
  - genotype: 1B
    reference: HCV1B-Con1-NS5a
    region: NS5a
    rules: SCORE FROM ( L28M => 4, L31IMV => 4, L31!FILMV => "Effect unknown",
       P58D => 8, P58!DPQRST => "Effect unknown", A92K => 8, A92T => 4,
       A92!AEKTV => "Effect unknown", Y93CS => 4, Y93HN => 8,
       Y93!CFHLNSY => "Effect unknown" )
  - genotype: '2'
    reference: HCV2-JFH-1-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '3'
    reference: HCV3-S52-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '4'
    reference: HCV4-ED43-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '5'
    reference: HCV5-SA13-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  name: Ledipasvir
- code: OMB
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS5a
    region: NS5a
    rules: SCORE FROM ( K24R => 4, M28A => 4, M28TV => 8,
       M28!AMTV => "Effect unknown", Q30EKRY => 8,
       Q30!EHKLNQRTY => "Effect unknown", L31V => 8, L31!ILMV => "Effect unknown",
       P32L => 4, H54Y => 4, H58D => 8, H58PR => 4, H58!DHPR => "Effect unknown",
       E62D => 4, Y93CFHLNS => 8, Y93!CFHLNSY => "Effect unknown" )
  - genotype: 1B
    reference: HCV1B-Con1-NS5a
    region: NS5a
    rules: SCORE FROM ( L28M => 4, L28T => 8, L28!LMT => "Effect unknown",
       P29d => 8, P29!P => "Effect unknown", R30Q => 4, L31FMV => 4,
       L31!FILMTV => "Effect unknown", Q54Y => 4, P58S => 4, Y93HN => 8,
       Y93S => 4, Y93!HNSY => "Effect unknown" )
  - genotype: '2'
    reference: HCV2-JFH-1-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '3'
    reference: HCV3-S52-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '4'
    reference: HCV4-ED43-NS5a
    region: NS5a
    rules: SCORE FROM ( L28S => 4, L28V => 8, L28!LSV => "Effect unknown",
       M31I => 4, P58S => 4 )
  - genotype: '5'
    reference: HCV5-SA13-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => "Not indicated" )
  name: Ombitasvir
- code: PIB
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS5a
    region: NS5a
    rules: SCORE FROM ( K24EQR => 4, K24!EKQR => "Effect unknown", M28ATV => 4,
       M28G => 8, M28!AGMTV => "Effect unknown", P29QR => 4,
       P29!PQR => "Effect unknown", Q30Dd => 8, Q30EGHKLR => 4,
       Q30!DEGHKLQRY => "Effect unknown", L31M => 4, H58CDY => 4,
       H58!CDHPRY => "Effect unknown", E62A => 8, E62!ADE => "Effect unknown",
       Y93HN => 8, Y93!CFHLNSY => "Effect unknown" )
  - genotype: 1B
    reference: HCV1B-Con1-NS5a
    region: NS5a
    rules: SCORE FROM ( L28M => 4, P29d => 4, R30Q => 4, L31K => 4, P32KNRT => 4,
       P32d => 8, P32!KNPRT => "Effect unknown" )
  - genotype: '2'
    reference: HCV2-JFH-1-NS5a
    region: NS5a
    rules: SCORE FROM ( L31M => 4 )
  - genotype: '3'
    reference: HCV3-S52-NS5a
    region: NS5a
    rules: SCORE FROM ( S24FG => 4, S24!FGS => "Effect unknown", M28GK => 4,
       M28!GKMT => "Effect unknown", P29Q => 4, A30GK => 4,
       A30!AGK => "Effect unknown", L31FIM => 4, L31!FILM => "Effect unknown",
       E92!E => "Effect unknown", Y93H => 4, Y93!HY => "Effect unknown" )
  - genotype: '4'
    reference: HCV4-ED43-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => 0 )
  - genotype: '5'
    reference: HCV5-SA13-NS5a
    region: NS5a
    rules: SCORE FROM (  T93A => 4, T93!TA => "Effect unknown" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS5a
    region: NS5a
    rules: SCORE FROM ( TRUE => 0 )
  name: Pibrentasvir
- code: PAR
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS3
    region: NS3
    rules: SCORE FROM ( V36AMT => 4, V36!ALMTV => "Effect unknown", F43L => 8,
       F43!FL => "Effect unknown", V55I => 4, Y56H => 4, Q80KL => 4,
       Q80!KLQR => "Effect unknown", I132V => 4, R155GKTW => 8, R155SV => 4,
       R155!GKMRSTVW => "Effect unknown", A156G => 4, A156T => 8,
       A156!AGT => "Effect unknown", D168!CDGMPQRSW => 8,
       D168CGMPQRSW => "Effect unknown", P334S => 4, S342P => 4, E357K => 4,
       V406AI => 4, V406!AIV => "Effect unknown", T449I => 4, P470S => 4 )
  - genotype: 1B
    reference: HCV1B-Con1-NS3
    region: NS3
    rules: SCORE FROM ( Y56FH => 4, R155K => 8, R155!KR => "Effect unknown",
       A156T => 4, A156V => 8, A156!ASTV => "Effect unknown", D168AFHKTVY => 8,
       D168ILN => 4, D168CGMPQRSW => "Effect unknown", E357K => 4 )
  - genotype: '2'
    reference: HCV2-JFH-1-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '3'
    reference: HCV3-S52-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '4'
    reference: HCV4-ED43-NS3
    region: NS3
    rules: SCORE FROM ( Y56H => 8, Y56!HY => "Effect unknown", R155C => 8,
       R155!CR => "Effect unknown", A156TV => 8, A156!ATV => "Effect unknown",
       D168HV => 8, D168!DHV => "Effect unknown" )
  - genotype: '5'
    reference: HCV5-SA13-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  name: Paritaprevir
- code: SOF-EPC
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS5b
    region: NS5b
    rules: SCORE FROM ( D61G => 4, S62N => 4, D66G => 4, F101L => 4, A112T => 4,
       N142T => 4, L159F => 4, L159!FL => "Effect unknown", E202G => 4,
       E237G => 4, S282GRT => 8, S282!GRST => 4, C316HR => 4,
       C316!CHR => "Effect unknown", L320IV => 4, L320!ILV => "Effect unknown",
       V321AFI => 4, V321!AFIV => "Effect unknown", Q355H => 4, F415Y => 4,
       S473T => 4, N590d => 4 )
  - genotype: 1B
    reference: HCV1B-Con1-NS5b
    region: NS5b
    rules: SCORE FROM ( N142S => 4, L159!L => "Effect unknown", S282GRT => 8,
       S282!GRST => 4, C316!C => "Effect unknown",
       L320!L => "Effect unknown", V321!V => "Effect unknown", K355T => 4 )
  - genotype: '2'
    reference: HCV2-JFH-1-NS5b
    region: NS5b
    rules: SCORE FROM ( L159!L => "Effect unknown", S282GRT => 8,
       S282!GRST => 4, C316!C => "Effect unknown",
       M289I => 4, L320!L => "Effect unknown", V321!V => "Effect unknown" )
  - genotype: '3'
    reference: HCV3-S52-NS5b
    region: NS5b
    rules: SCORE FROM ( K100R => 4, R120C => 4, N142ST => 4, L159F => 4,
       L159!FL => "Effect unknown", E237G => 4, S282GRT => 8,
       S282!GRST => 4, L314FIP => 4, C316!C => "Effect unknown",
       L320FI => 4, L320!FIL => "Effect unknown", V321A => 4,
       V321!AV => "Effect unknown", Q355HR => 4 )
  - genotype: '4'
    reference: HCV4-ED43-NS5b
    region: NS5b
    rules: SCORE FROM ( L159!L => "Effect unknown", E237G => 4, S282GRT => 8,
       S282!GRST => 4, C316!C => "Effect unknown",
       L320!L => "Effect unknown", V321I => 4, V321!IV => "Effect unknown" )
  - genotype: '5'
    reference: HCV5-SA13-NS5b
    region: NS5b
    rules: SCORE FROM ( L159!L => "Effect unknown", S282GRT => 8,
       S282!GRST => 4, M289I => 4, C316!C => "Effect unknown",
       L320!L => "Effect unknown", V321!V => "Effect unknown" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS5b
    region: NS5b
    rules: SCORE FROM ( L159!L => "Effect unknown", S282GRT => 8,
       S282!GRST => 4, C316!C => "Effect unknown",
       L320!L => "Effect unknown", V321!V => "Effect unknown" )
  - genotype: 6E
    reference: HCV6-EUHK2-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Data not available" )
  name: Sofosbuvir in Epclusa
- code: SOF-HAR
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS5b
    region: NS5b
    rules: SCORE FROM ( D61G => 4, S62N => 4, D66G => 4, F101L => 4, A112T => 4,
       N142T => 4, L159F => 4, L159!FL => "Effect unknown", E202G => 4,
       E237G => 4, S282GRT => 8, S282!GRST => 4, C316HR => 4,
       C316!CHR => "Effect unknown", L320IV => 4, L320!ILV => "Effect unknown",
       V321AFI => 4, V321!AFIV => "Effect unknown", Q355H => 4, F415Y => 4,
       S473T => 4, N590d => 4 )
  - genotype: 1B
    reference: HCV1B-Con1-NS5b
    region: NS5b
    rules: SCORE FROM ( N142S => 4, L159!L => "Effect unknown", S282GRT => 8,
       S282!GRST => 4, C316!C => "Effect unknown",
       L320!L => "Effect unknown", V321!V => "Effect unknown", K355T => 4 )
  - genotype: '2'
    reference: HCV2-JFH-1-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '3'
    reference: HCV3-S52-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '4'
    reference: HCV4-ED43-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '5'
    reference: HCV5-SA13-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS5b
    region: NS5b
    rules: SCORE FROM ( TRUE => "Not indicated" )
  name: Sofosbuvir in Harvoni
- code: SIM
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS3
    region: NS3
    rules: SCORE FROM ( A5V => 4, V36L => 4, Q41R => 4, T54S => 4, V71A => 4,
       Q80KR => 8, Q80L => 4, Q80!KLQR => "Effect unknown", G120S => 4,
       S122ACGIT => 4, S122NR => 8, S122!ACGINRST => "Effect unknown", R123M => 4,
       I132L => 4, R155GQ => 4, R155KT => 8, R155!GKQRT => "Effect unknown",
       A156GTV => 8, A156!AGTV => "Effect unknown", D168AEHV => 8, D168FT => 4,
       D168!ADEFHTV => "Effect unknown", I170T => 8, I170V => 4,
       I170!ITV => "Effect unknown", N174RS => 4, T178I => 4, T343N => 4,
       T344I => 4, L356F => 4, A477T => 4, V511I => 4, G534S => 4, E555D => 4,
       V629I => 4 )
  - genotype: 1B
    reference: HCV1B-Con1-NS3
    region: NS3
    rules: SCORE FROM ( A39T => 4, F43ISV => 8, F43!FILSV => "Effect unknown",
       T46S => 4, V48I => 4, S61L => 4, Q80H => 4, Q80KR => 8,
       Q80!GHKLQR => "Effect unknown", Q86R => 4, R117C => 4, S122AGIT => 4,
       S122R => 8, S122!AGIRST => "Effect unknown", R155GKQTW => 8,
       R155!GIKMQRTW => "Effect unknown", A156GTV => 8, A156S => 4,
       A156!AGSTV => "Effect unknown", D168AEHINQTVY => 8, D168F => 4,
       D168CKLMPRSW => "Effect unknown", V170IT => 4,
       V170!AITV => "Effect unknown", S174F => 4, S280P => 4, T344A => 4,
       T358F => 4, G383S => 4, I426V => 4, T448A => 4, I472V => 4, V535A => 4,
       P574AS => 4, V629I => 4 )
  - genotype: '2'
    reference: HCV2-JFH-1-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '3'
    reference: HCV3-S52-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '4'
    reference: HCV4-ED43-NS3
    region: NS3
    rules: SCORE FROM ( Q80!Q => "Effect unknown", T122!T => "Effect unknown",
       R155K => 8, R155!KR => "Effect unknown", A156G => 8,
       A156!AGM => "Effect unknown", D168!D => "Effect unknown",
       V170!V => "Effect unknown" )
  - genotype: '5'
    reference: HCV5-SA13-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS3
    region: NS3
    rules: SCORE FROM ( TRUE => "Not indicated" )
  name: Simeprevir
- code: VEL
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS5a
    region: NS5a
    rules: SCORE FROM ( K24MT => 4, K24CDFHILPVWY => "Effect unknown", M28AV => 4,
       M28GT => 8, M28!AGILMTV => "Effect unknown", Q30EK => 8, Q30GHLRT => 4,
       Q30ADFMNPW => "Effect unknown", L31F => 4, L31IMV => 8,
       L31!FILMV => "Effect unknown", P32L => 8, P32!LP => "Effect unknown",
       S38Y => 4, H58D => 8, H58NPR => 4, H58!CDHLNPQRY => "Effect unknown",
       S85N => 4, A92K => 8, A92!AKPTV => "Effect unknown", Y93CHNRSW => 8,
       Y93LT => 4, Y93ADEGIKMPQV => "Effect unknown", L153V => 4 )
  - genotype: 1B
    reference: HCV1B-Con1-NS5a
    region: NS5a
    rules: SCORE FROM ( Q24K => 4, L31IMV => 4, L31!FILMV => "Effect unknown",
       P58T => 4, A92K => 8, A92!AEKPTV => "Effect unknown", Y93CRST => 4,
       Y93HN => 8, Y93!CFHLNRSTY => "Effect unknown" )
  - genotype: '2'
    reference: HCV2-JFH-1-NS5a
    region: NS5a
    rules: SCORE FROM ( F28C => 4, F28S => 8, F28!CFLSV => "Effect unknown",
       L31IM => 4, L31V => 8, L31!ILMV => "Effect unknown", P58A => 4, C92RS => 4,
       C92T => 8, C92!ACKNRST => "Effect unknown", Y93F => 4, Y93HN => 8,
       Y93!CFHLNSTY => "Effect unknown" )
  - genotype: '3'
    reference: HCV3-S52-NS5a
    region: NS5a
    rules: SCORE FROM ( S14E => 4, M28V => 4, M28T => 8,
       M28!LMTV => "Effect unknown", A30HRV => 4, A30K => 8,
       A30!AHKQRSV => "Effect unknown", L31FM => 8, L31PV => 4,
       L31!FLMPV => "Effect unknown", S38PY => 4, S38!PSY => "Effect unknown",
       V52M => 4, P58GLT => 4, P58!AGHLPST => "Effect unknown", H85Y => 4,
       E92K => 4, Y93HS => 8, Y93NR => 4, Y93!FHNRSY => "Effect unknown",
       S103DP => 4, A291P => 4, S379P => 4, S385Q => 4, R404K => 4, P407S => 4 )
  - genotype: '4'
    reference: HCV4-ED43-NS5a
    region: NS5a
    rules: SCORE FROM ( L28T => 8, L28!LMTV => "Effect unknown", L30R => 4,
       M31V => 4, P32L => 4, H54R => 4, Y93CW => 4, Y93HNS => 8,
       Y93!CHNSWY => "Effect unknown" )
  - genotype: '5'
    reference: HCV5-SA13-NS5a
    region: NS5a
    rules: SCORE FROM ( L31I => 4 )
  - genotype: '6'
    reference: HCV6-EUHK2-NS5a
    region: NS5a
    rules: SCORE FROM ( F28MV => 4, F28!AFMV => "Effect unknown", L31IM => 4,
       L31V => 8, L31!ILMV => "Effect unknown", P32ALQR => 8,
       P32!ALPQR => "Effect unknown", T58GH => 4, T58!AGHPST => "Effect unknown",
       A92T => 4, T93AHNS => 4, T93!ACFHLNSTY => "Effect unknown" )
  name: Velpatasvir
- code: VOX
  genotypes:
  - genotype: 1A
    reference: HCV1A-H77-NS3
    region: NS3
    rules: SCORE FROM ( V36AG => 4, V36!AGILMV => "Effect unknown", Q41R => 4,
       F43S => 4, Q80K => 4, R155G => 4, R155W => 8,
       R155!AGKRTW => "Effect unknown", A156GIMPDV => 4, A156LT => 8,
       A156!AGILMPSTV => "Effect unknown", D168AFITV => 4, D168KLR => 8,
       D168CMPQW => "Effect unknown" )
  - genotype: 1B
    reference: HCV1B-Con1-NS3
    region: NS3
    rules: SCORE FROM ( V36AM => 4, V36!AIMSV => "Effect unknown", S122D => 4,
       R155W => 8, R155!KRW => "Effect unknown", A156S => 4, A156TV => 8,
       A156!ASTV => "Effect unknown", D168VY => 4,
       D168!ADEGVY => "Effect unknown", V170A => 4 )
  - genotype: '2'
    reference: HCV2-JFH-1-NS3
    region: NS3
    rules: SCORE FROM ( F43V => 4, A156LTV => 8, A156!AGLTV => "Effect unknown" )
  - genotype: '3'
    reference: HCV3-S52-NS3
    region: NS3
    rules: SCORE FROM ( Q41K => 8, Q41R => 4, Q41!KQR => "Effect unknown",
       V55A => 4, Q80K => 8, Q80!KQR => "Effect unknown", A156TV => 8,
       A156!ATV => "Effect unknown", Q168R => 4, Q168!HKQR => "Effect unknown",
       L175M => 4, A294V => 4 )
  - genotype: '4'
    reference: HCV4-ED43-NS3
    region: NS3
    rules: SCORE FROM ( Q41R => 4, A156LTV => 8, A156!ALTV => "Effect unknown",
       D168ETV => 4, D168!DEKTV => "Effect unknown", T185S => 4, T382S => 4 )
  - genotype: '5'
    reference: HCV5-SA13-NS3
    region: NS3
    rules: SCORE FROM ( A156!A => "Effect unknown", D168AK => 4, D168HRY => 8,
       D168!ADEHKRVY => "Effect unknown" )
  - genotype: '6'
    reference: HCV6-EUHK2-NS3
    region: NS3
    rules: SCORE FROM ( Q41KR => 4, Q41!KQR => "Effect unknown", Y56H => 4,
       A156!A => "Effect unknown", D168AEH => 4,
       D168!ADEHVY => "Effect unknown" )
  name: Voxilaprevir