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1 FastTree Version 2.1.7 SSE3
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2 Alignment: standard input
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3 Nucleotide distances: Jukes-Cantor Joins: balanced Support: SH-like 1000
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4 Search: Normal +NNI +SPR (2 rounds range 10) +ML-NNI opt-each=1
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5 TopHits: 1.00*sqrtN close=default refresh=0.80
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6 ML Model: Jukes-Cantor, CAT approximation with 20 rate categories
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7 Ignored unknown character K (seen 1 times)
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8 Ignored unknown character R (seen 4 times)
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9 Ignored unknown character S (seen 5 times)
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10 Ignored unknown character X (seen 240 times)
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11 Ignored unknown character Y (seen 2 times)
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12 1.46 seconds: Top hits for 399 of 533 seqs (at seed 200)
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13 1.69 seconds: Top hits for 459 of 533 seqs (at seed 300)
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14 1.87 seconds: Top hits for 498 of 533 seqs (at seed 400)
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15 2.06 seconds: Top hits for 526 of 533 seqs (at seed 500)
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16 3.31 seconds: Joined 100 of 530
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17 4.88 seconds: Joined 200 of 530
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18 6.11 seconds: Joined 300 of 530
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19 7.43 seconds: Joined 400 of 530
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20 8.67 seconds: Joined 500 of 530
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21 Initial topology in 8.86 seconds
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22 Refining topology: 36 rounds ME-NNIs, 2 rounds ME-SPRs, 18 rounds ML-NNIs
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23 8.86 seconds: ME NNI round 1 of 36, 1 of 531 splits
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24 9.05 seconds: ME NNI round 1 of 36, 201 of 531 splits, 40 changes (max delta 0.029)
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25 9.23 seconds: ME NNI round 1 of 36, 401 of 531 splits, 71 changes (max delta 0.029)
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26 9.36 seconds: ME NNI round 2 of 36, 1 of 531 splits
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27 9.54 seconds: ME NNI round 2 of 36, 201 of 531 splits, 19 changes (max delta 0.013)
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28 9.73 seconds: ME NNI round 2 of 36, 401 of 531 splits, 40 changes (max delta 0.016)
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29 9.85 seconds: ME NNI round 3 of 36, 1 of 531 splits
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30 10.04 seconds: ME NNI round 3 of 36, 201 of 531 splits, 17 changes (max delta 0.003)
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31 10.19 seconds: ME NNI round 4 of 36, 1 of 531 splits
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32 10.38 seconds: ME NNI round 4 of 36, 201 of 531 splits, 10 changes (max delta 0.005)
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33 10.52 seconds: ME NNI round 5 of 36, 101 of 531 splits, 5 changes (max delta 0.003)
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34 10.65 seconds: SPR round 1 of 2, 1 of 1064 nodes
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35 12.20 seconds: SPR round 1 of 2, 101 of 1064 nodes
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36 13.72 seconds: SPR round 1 of 2, 201 of 1064 nodes
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37 15.33 seconds: SPR round 1 of 2, 301 of 1064 nodes
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38 16.82 seconds: SPR round 1 of 2, 401 of 1064 nodes
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39 18.48 seconds: SPR round 1 of 2, 501 of 1064 nodes
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40 19.91 seconds: SPR round 1 of 2, 601 of 1064 nodes
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41 21.36 seconds: SPR round 1 of 2, 701 of 1064 nodes
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42 23.06 seconds: SPR round 1 of 2, 801 of 1064 nodes
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43 24.59 seconds: SPR round 1 of 2, 901 of 1064 nodes
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44 26.04 seconds: SPR round 1 of 2, 1001 of 1064 nodes
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45 27.28 seconds: ME NNI round 13 of 36, 1 of 531 splits
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46 27.46 seconds: ME NNI round 13 of 36, 201 of 531 splits, 1 changes (max delta 0.007)
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47 27.64 seconds: ME NNI round 13 of 36, 401 of 531 splits, 2 changes (max delta 0.007)
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48 27.76 seconds: ME NNI round 14 of 36, 1 of 531 splits
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49 27.94 seconds: ME NNI round 14 of 36, 201 of 531 splits, 1 changes (max delta 0.003)
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50 28.11 seconds: ME NNI round 14 of 36, 401 of 531 splits, 1 changes (max delta 0.003)
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51 28.23 seconds: ME NNI round 15 of 36, 1 of 531 splits
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52 29.84 seconds: SPR round 2 of 2, 101 of 1064 nodes
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53 31.44 seconds: SPR round 2 of 2, 201 of 1064 nodes
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54 33.04 seconds: SPR round 2 of 2, 301 of 1064 nodes
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55 34.51 seconds: SPR round 2 of 2, 401 of 1064 nodes
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56 36.07 seconds: SPR round 2 of 2, 501 of 1064 nodes
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57 37.52 seconds: SPR round 2 of 2, 601 of 1064 nodes
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58 38.98 seconds: SPR round 2 of 2, 701 of 1064 nodes
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59 40.71 seconds: SPR round 2 of 2, 801 of 1064 nodes
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60 42.29 seconds: SPR round 2 of 2, 901 of 1064 nodes
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61 43.91 seconds: SPR round 2 of 2, 1001 of 1064 nodes
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62 45.04 seconds: ME NNI round 25 of 36, 1 of 531 splits
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63 45.22 seconds: ME NNI round 25 of 36, 201 of 531 splits, 1 changes (max delta 0.000)
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64 45.40 seconds: ME NNI round 25 of 36, 401 of 531 splits, 1 changes (max delta 0.000)
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65 45.51 seconds: ME NNI round 26 of 36, 1 of 531 splits
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66 45.70 seconds: ME NNI round 26 of 36, 201 of 531 splits, 0 changes
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67 45.88 seconds: ME NNI round 26 of 36, 401 of 531 splits, 0 changes
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68 Total branch-length 34.168 after 46.56 sec
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69 46.66 seconds: ML Lengths 1 of 531 splits
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70 47.64 seconds: ML Lengths 101 of 531 splits
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71 48.63 seconds: ML Lengths 201 of 531 splits
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72 49.59 seconds: ML Lengths 301 of 531 splits
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73 50.54 seconds: ML Lengths 401 of 531 splits
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74 51.50 seconds: ML Lengths 501 of 531 splits
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75 51.81 seconds: ML NNI round 1 of 18, 1 of 531 splits
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76 54.77 seconds: ML NNI round 1 of 18, 101 of 531 splits, 15 changes (max delta 19.328)
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77 57.67 seconds: ML NNI round 1 of 18, 201 of 531 splits, 36 changes (max delta 19.328)
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78 60.58 seconds: ML NNI round 1 of 18, 301 of 531 splits, 52 changes (max delta 19.328)
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79 63.61 seconds: ML NNI round 1 of 18, 401 of 531 splits, 72 changes (max delta 28.170)
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80 66.61 seconds: ML NNI round 1 of 18, 501 of 531 splits, 83 changes (max delta 28.170)
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81 ML-NNI round 1: LogLk = -287815.653 NNIs 89 max delta 28.17 Time 67.75
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82 68.12 seconds: Site likelihoods with rate category 1 of 20
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83 68.50 seconds: Site likelihoods with rate category 2 of 20
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84 68.87 seconds: Site likelihoods with rate category 3 of 20
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85 69.25 seconds: Site likelihoods with rate category 4 of 20
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86 69.62 seconds: Site likelihoods with rate category 5 of 20
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87 70.00 seconds: Site likelihoods with rate category 6 of 20
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88 70.37 seconds: Site likelihoods with rate category 7 of 20
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89 70.75 seconds: Site likelihoods with rate category 8 of 20
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90 71.12 seconds: Site likelihoods with rate category 9 of 20
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91 71.50 seconds: Site likelihoods with rate category 10 of 20
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92 71.87 seconds: Site likelihoods with rate category 11 of 20
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93 72.25 seconds: Site likelihoods with rate category 12 of 20
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94 72.62 seconds: Site likelihoods with rate category 13 of 20
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95 72.99 seconds: Site likelihoods with rate category 14 of 20
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96 73.36 seconds: Site likelihoods with rate category 15 of 20
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97 73.74 seconds: Site likelihoods with rate category 16 of 20
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98 74.11 seconds: Site likelihoods with rate category 17 of 20
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99 74.49 seconds: Site likelihoods with rate category 18 of 20
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100 74.86 seconds: Site likelihoods with rate category 19 of 20
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101 75.24 seconds: Site likelihoods with rate category 20 of 20
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102 Switched to using 20 rate categories (CAT approximation)
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103 Rate categories were divided by 0.780 so that average rate = 1.0
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104 CAT-based log-likelihoods may not be comparable across runs
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105 Use -gamma for approximate but comparable Gamma(20) log-likelihoods
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106 75.44 seconds: ML NNI round 2 of 18, 1 of 531 splits
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107 77.30 seconds: ML NNI round 2 of 18, 101 of 531 splits, 6 changes (max delta 8.408)
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108 79.63 seconds: ML NNI round 2 of 18, 201 of 531 splits, 16 changes (max delta 11.916)
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109 81.66 seconds: ML NNI round 2 of 18, 301 of 531 splits, 26 changes (max delta 12.582)
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110 83.77 seconds: ML NNI round 2 of 18, 401 of 531 splits, 37 changes (max delta 12.582)
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111 85.45 seconds: ML NNI round 2 of 18, 501 of 531 splits, 45 changes (max delta 12.582)
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112 ML-NNI round 2: LogLk = -243521.538 NNIs 47 max delta 12.58 Time 86.22
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113 86.22 seconds: ML NNI round 3 of 18, 1 of 531 splits
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114 87.60 seconds: ML NNI round 3 of 18, 101 of 531 splits, 2 changes (max delta 2.600)
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115 89.51 seconds: ML NNI round 3 of 18, 201 of 531 splits, 10 changes (max delta 3.628)
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116 90.90 seconds: ML NNI round 3 of 18, 301 of 531 splits, 12 changes (max delta 3.628)
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117 ML-NNI round 3: LogLk = -243454.047 NNIs 17 max delta 4.33 Time 92.41
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118 92.40 seconds: ML NNI round 4 of 18, 1 of 531 splits
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119 93.59 seconds: ML NNI round 4 of 18, 101 of 531 splits, 0 changes
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120 94.89 seconds: ML NNI round 4 of 18, 201 of 531 splits, 4 changes (max delta 8.267)
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121 ML-NNI round 4: LogLk = -243401.668 NNIs 8 max delta 15.05 Time 95.80
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122 95.79 seconds: ML NNI round 5 of 18, 1 of 531 splits
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123 97.12 seconds: ML NNI round 5 of 18, 101 of 531 splits, 1 changes (max delta 5.470)
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124 ML-NNI round 5: LogLk = -243385.290 NNIs 5 max delta 5.47 Time 97.70
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125 97.69 seconds: ML NNI round 6 of 18, 1 of 531 splits
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126 ML-NNI round 6: LogLk = -243379.465 NNIs 0 max delta 0.00 Time 98.56
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127 Turning off heuristics for final round of ML NNIs (converged)
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128 98.55 seconds: ML NNI round 7 of 18, 1 of 531 splits
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129 101.64 seconds: ML NNI round 7 of 18, 101 of 531 splits, 3 changes (max delta 5.543)
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130 104.85 seconds: ML NNI round 7 of 18, 201 of 531 splits, 4 changes (max delta 5.543)
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131 107.89 seconds: ML NNI round 7 of 18, 301 of 531 splits, 8 changes (max delta 5.543)
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132 111.07 seconds: ML NNI round 7 of 18, 401 of 531 splits, 9 changes (max delta 5.543)
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133 114.20 seconds: ML NNI round 7 of 18, 501 of 531 splits, 12 changes (max delta 20.657)
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134 ML-NNI round 7: LogLk = -243045.843 NNIs 13 max delta 20.66 Time 115.43 (final)
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135 115.43 seconds: ML Lengths 1 of 531 splits
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136 116.25 seconds: ML Lengths 101 of 531 splits
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137 117.06 seconds: ML Lengths 201 of 531 splits
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138 117.84 seconds: ML Lengths 301 of 531 splits
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139 118.68 seconds: ML Lengths 401 of 531 splits
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140 119.49 seconds: ML Lengths 501 of 531 splits
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141 Optimize all lengths: LogLk = -243039.348 Time 120.01
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142 129.12 seconds: ML split tests for 100 of 530 internal splits
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143 138.49 seconds: ML split tests for 200 of 530 internal splits
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144 148.16 seconds: ML split tests for 300 of 530 internal splits
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145 156.37 seconds: ML split tests for 400 of 530 internal splits
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146 165.18 seconds: ML split tests for 500 of 530 internal splits
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147 Total time: 167.98 seconds Unique: 533/533 Bad splits: 5/530 Worst delta-LogLk 10.254
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