ART_SOLiD is a simulation program to generate sequence read data of SOLiD sequencing reads. ART generates reads according to a SOLiD read error profile. The built-in error profile is an empiricial error profile summarized from large SOLiD sequencing data. ART has been using for testing or benchmarking a variety of method or tools for next-generation sequencing data analysis, including read alignment, de novo assembly, detection of SNP, CNV, or other structure variation.
art_SOLiD can generate both single-end, matepair, and paired-end of SOLiD sequencing platform. art_SOLiD also support amplicon sequencing simulation with RNA references.