What it does

PyProphet: Semi-supervised learning and scoring of OpenSWATH results.

Merge function of PyProphet: Takes several osw input files and merges them. For large experiments, it is recommended to subsample first.

PyProphet is a Python re-implementation of the mProphet algorithm (Reiter 2010 Nature Methods) optimized for SWATH-MS data acquired by data-independent acquisition (DIA). The algorithm was originally published in (Telemann 2014 Bioinformatics) and has since been extended to support new data types and analysis modes (Rosenberger 2017, Nature biotechnology and Nature methods).

For more information, visit http://openswath.org/en/latest/docs/pyprophet.html