Uses Tracy-Widom theory on random matrices to estimate the optimal number of clusters k.

It creates and populates the k_estimation item of the sc3 slot of the metadata(object).

Documentation can be found at http://bioconductor.org/packages/release/bioc/vignettes/SC3/inst/doc/SC3.html

Version history

1.8.0+galaxy0: Initial contribution. Ni Huang and Carlos Talavera-Lopez, Expression Atlas team https://www.ebi.ac.uk/gxa/home at EMBL-EBI https://www.ebi.ac.uk/ and Teichmann Lab at Wellcome Sanger Institute.