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Closed-reference OTU picking (version 1.9.1.0)
It specifies changes to the default behavior

What it does

This script picks OTUs using a closed reference and constructs an OTU table. Taxonomy is assigned using a pre-defined taxonomy map of reference sequence OTU to taxonomy. If full-length genomes are provided as the reference sequences, this script applies the Shotgun UniFrac method.

More information about this tool is available on QIIME documentation.