This tool takes two Kinamine outputs (substrates and substrate background frequency files) and finds the two halves of the symmetrical difference. https://en.wikipedia.org/wiki/Symmetric_difference

Let us call the two INPUT substrate files 'A' and 'B'. Let us call the two OUTPUT substrate files 'Y' and 'Z'. 'Y' consists of all 'A' that are not in 'B'. 'Z' consists of all 'B' that are not in 'A'. In symbolic logic:

Y ⇔ A ∧ ¬B

Z ⇔ B ∧ ¬A

The associated Substrate Background Frequency files for each consists of all the proteins associated with that substrate file.