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Dr. Disco (detect) (version 0.14.0)
Larger numbers boost performance but result in suboptimal results. Values of 8 and below are considered to be very safe (this corresponds to initiate merging already from clusters that consist of 2 or 3 reads).

What it does

This tool detects junctions in ('dr-disco fix' prepared) Chimeric alignments and tries to reconstruct fusion genes and genomic breakpoints using a Graph data structure. This software is in particular designed for RNA-Seq data prepared with random hexamer priming because of the presence of intronic reads.

Attribution

This work is part of Youri Hoogstrate's PhD thesis.