| Next changeset 1:3c3eb51a6414 (2017-02-06) |
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Commit message:
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added:
findDMR/.Rhistory findDMR/._.DS_Store findDMR/findDMR.R findDMR/findDMR.xml findDMR/test-data/._.DS_Store findDMR/test-data/._input.csv findDMR/test-data/DMR.bed findDMR/test-data/IlmnTable.csv findDMR/test-data/MetaTable.csv findDMR/test-data/gmTable.csv findDMR/test-data/input.csv findDMR/tool_dependencies.xml |
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| diff -r 000000000000 -r ca66a1487d4a findDMR/.Rhistory --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/findDMR/.Rhistory Mon Feb 06 06:10:47 2017 -0500 |
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| @@ -0,0 +1,3 @@ +clusterSize=2 +class(clusterSize) +type(clusterSize) |
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| diff -r 000000000000 -r ca66a1487d4a findDMR/findDMR.R --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/findDMR/findDMR.R Mon Feb 06 06:10:47 2017 -0500 |
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| @@ -0,0 +1,46 @@ +require("minfi", quietly = TRUE) +require("ChIPseeker", quietly = TRUE) +require("ChIPpeakAnno", quietly = TRUE) +require("data.table", quietly = TRUE) + + +args <- commandArgs(trailingOnly = TRUE) +GSMTable = args[1] +IlmnTable = args[2] +gmTable = args[3] +cutoff = as.numeric(args[4]) +clusterSize = as.numeric(args[5]) +DMR = args[6] + +#GSMTable<-("test-data/input.csv") +TAB = fread(GSMTable) +#IlmnTable <- ("test-data/IlmnTable.csv") +IlmnInfo = fread(IlmnTable) +#gmTable<-("test-data/gmTable.csv") +gmSet = fread(gmTable) + +# bumphunter Run with processed data +designMatrix <- model.matrix( ~ TAB$Phenotype) + +bumps <- bumphunter( + as.matrix(gmSet), + design = designMatrix, + pos = IlmnInfo$BP, + cutoff = cutoff, + chr = IlmnInfo$CHR +) + +# choose DMR's of a certain length threshold +DMRTable <- bumps$table[which(bumps$table$L >= clusterSize), ] +DMRInfo <- data.table(DMRTable$chr, DMRTable$start, DMRTable$end) + + +#DMR<-("test-data/DMR.bed") +write.table( + DMRInfo, + DMR, + quote = F, + sep = "\t", + row.names = F, + col.names = F +) |
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| diff -r 000000000000 -r ca66a1487d4a findDMR/findDMR.xml --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/findDMR/findDMR.xml Mon Feb 06 06:10:47 2017 -0500 |
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| @@ -0,0 +1,55 @@ +<tool id="DMR" name="findDMR" version="1.16.2"> + <requirements> + <package name="methyldata_1_16_2" version="1.16.2"> + <repository name="methyldata_1_16_2" owner="testtool" prior_installation_required="True" /> + </package> +</requirements> +<stdio> + <exit_code range="1:" /> +</stdio> + <command> Rscript $__tool_directory__/findDMR.R "$GSMTable" "$IlmnTable" "$gmTable" "$cutoff" "$clusterSize" "$DMR"</command> + <inputs> + <param optional="false" format="csv" name="GSMTable" type="data" value="" help="GSM ID and phenotype table." label="[required] GSMTable"> + <validator type="empty_field" message="This field is required."/> + </param> + <param optional="false" format="csv" name="IlmnTable" type="data" value="" help="CG, CHR, BP table." label="[required] IlmnTable"> + <validator type="empty_field" message="This field is required."/> + </param> + <param optional="false" format="csv" name="gmTable" type="data" value="" help="gmSet of data." label="[required] gmTable"> + <validator type="empty_field" message="This field is required."/> + </param> + <param name="cutoff" type="float" value="" + label="Enter cutoff size (number)" + help="e.g. '0.2'" > + </param> + <param name="clusterSize" type="float" value="" + label="Enter cluster size (number)" + help="e.g. '2'" > + </param> + </inputs> + <outputs> + <data format="bed" name="DMR" label="DMR.bed"/> + </outputs> + <tests> + <test> + <param name="test"> + <element name="test-data"> + <collection type="data"> + <element name="GSMTable" value="test-data/input.csv"/> + <element name="IlmnTable" value="test-data/IlmnTable.csv"/> + <element name="gmTable" value="test-data/gmTable.csv"/> + <element name="cutoff" value="0.2"/> + <element name="clusterSize" value="2"/> + </collection> + </element> + </param> + <output format="bed" name="DMR" label="test-data/DMR.bed"/> + </test> + </tests> + <help> +**Description** +</help> +<citations> +DMR +</citations> +</tool> |
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| diff -r 000000000000 -r ca66a1487d4a findDMR/test-data/._.DS_Store |
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| Binary file findDMR/test-data/._.DS_Store has changed |
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| diff -r 000000000000 -r ca66a1487d4a findDMR/test-data/._input.csv |
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| Binary file findDMR/test-data/._input.csv has changed |
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| diff -r 000000000000 -r ca66a1487d4a findDMR/test-data/DMR.bed --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/findDMR/test-data/DMR.bed Mon Feb 06 06:10:47 2017 -0500 |
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| b'@@ -0,0 +1,9881 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| diff -r 000000000000 -r ca66a1487d4a findDMR/test-data/IlmnTable.csv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/findDMR/test-data/IlmnTable.csv Mon Feb 06 06:10:47 2017 -0500 |
| b |
| b'@@ -0,0 +1,485578 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|
| b |
| diff -r 000000000000 -r ca66a1487d4a findDMR/test-data/MetaTable.csv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/findDMR/test-data/MetaTable.csv Mon Feb 06 06:10:47 2017 -0500 |
| b |
| @@ -0,0 +1,2 @@ +"channel_count","characteristics_ch1","contact_address","contact_city","contact_country","contact_department","contact_institute","contact_name","contact_zip.postal_code","data_processing","data_row_count","description","extract_protocol_ch1","geo_accession","hyb_protocol","label_ch1","label_protocol_ch1","last_update_date","molecule_ch1","organism_ch1","platform_id","scan_protocol","series_id","source_name_ch1","status","submission_date","supplementary_file","taxid_ch1","title","type" +"1","sample type: melanoma cell line","Barngatan 2B","Lund","Sweden","Dept of Oncology","Lund University","Martin,,Lauss","22185","Raw intensities for methylated (M) and unmethylated (U) signal were extracted from Illumina’s GenomeStudio. Beta-values were calculated as M/(M+U). A total of 496 missing values (melanomas) were imputed using k-nearest neighbor imputation (k=10). For each sample we performed a peak-based correction of Illumina I and II chemical assays. For both assays we smoothed the beta values (Epanechnikov smoothing kernel) to estimate unmethylated and methylated peaks, respectively; and the unmethylated peak was moved to 0 and the methylated peak to 1 using linear scaling, with beta-values in between stretched accordingly. Beta-values below 0 were set back to 0 and values above 1 were set to 1.","485577","melanoma cell line","Genomic DNA was extracted from the biopsies using QIAamp DNA Mini Kit (Qiagen). A total of 500 ng of DNA were used for bisulfite treatment, using the EZ DNA Methylation Kit (Zymo). We hybridized 200 ng in 4 μl to the Infinium Human Methylation450 BeadChip array.","GSM1247787","Bisulphite converted DNA was amplified, fragmented and hybridised to Illumina Infinium Human Methylation450 Beadchip using standard Illumina protocol","Cy5 and Cy3","Standard Illumina Protocol","May 17 2015","genomic DNA","Homo sapiens","GPL13534","Arrays were imaged using BeadArray Reader using standard recommended Illumina scanner setting","GSE51547","SKMEL3","Public on May 17 2015","Oct 22 2013","NONE","9606","genomic DNA from Sample SKMEL3","genomic" |
| b |
| diff -r 000000000000 -r ca66a1487d4a findDMR/test-data/gmTable.csv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/findDMR/test-data/gmTable.csv Mon Feb 06 06:10:47 2017 -0500 |
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|
| b |
| diff -r 000000000000 -r ca66a1487d4a findDMR/test-data/input.csv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/findDMR/test-data/input.csv Mon Feb 06 06:10:47 2017 -0500 |
| b |
| @@ -0,0 +1,4 @@ +ID,Phenotype +GSM1247787,melanoma +GSM1247784,melanoma +GSM1247733,healthy |
| b |
| diff -r 000000000000 -r ca66a1487d4a findDMR/tool_dependencies.xml --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/findDMR/tool_dependencies.xml Mon Feb 06 06:10:47 2017 -0500 |
| b |
| @@ -0,0 +1,6 @@ +<?xml version="1.0"?> +<tool_dependency> + <package name="methyldata_1_16_2" version="1.16.2"> + <repository changeset_revision="ea44a0861444" name="methyldata_1_16_2" owner="testtool" prior_installation_required="True" toolshed="https://toolshed.g2.bx.psu.edu" /> + </package> +</tool_dependency> |