CONTRA is a tool for copy number variation (CNV) detection for targeted resequencing data such as those from whole-exome capture data. CONTRA calls copy number gains and losses for each target region with key strategies include the use of base-level log-ratios to remove GC-content bias, correction for an imbalanced library size effect on log-ratios, and the estimation of log-ratio variations via binning and interpolation. It takes standard alignment formats (BAM/SAM) and output in variant call format (VCF 4.0) for easy integration with other next generation sequencing analysis package. |
hg clone https://toolshed.g2.bx.psu.edu/repos/fcaramia/contra
Name | Version | Type | |
---|---|---|---|
R | 3.0.3 | package | |
bedtools | 2.17.0 | package | |
contra | 2.0.4 | package | |
samtools | 0.1.18 | package |
Name | Description | Version | Minimum Galaxy Version |
---|---|---|---|
: Copy Number Analysis for Targeted Resequencing | 1.0.0 | any | |
: Control files for Contra | 1.0.0 | any |