Single-nucleotide polymorphisms (SNPs) are often linked to critical phenotypes such as diseases or responses to vaccines, medications and environmental factors. However, the specific molecular mechanisms by which a causal SNP acts is usually not obvious. Changes in RNA secondary structure emerge as a possible explanation necessitating the development of methods to measure the impact of single-nucleotide variation on RNA structure. To answer this need, remuRNA commutes the relative entropy between the Boltzmann ensembles of the native and a mutant structure. |
hg clone https://toolshed.g2.bx.psu.edu/repos/rnateam/remurna
Name | Description | Version | Minimum Galaxy Version |
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Measurement of Single Nucleotide Polymorphism induced Changes of RNA Conformation | 1.0.0 | any |