Mercurial > repos > artbio > mutational_patterns
changeset 3:e332cf9dfa06 draft
"planemo upload for repository https://github.com/ARTbio/tools-artbio/tree/master/tools/mutational_patterns commit 0f7593f703ba0dfd12aea1c0460e371f08b57d2f"
| author | artbio |
|---|---|
| date | Thu, 24 Sep 2020 01:32:52 +0000 |
| parents | aea952be68cb |
| children | 7ba08c826888 |
| files | mutational_patterns.R mutational_patterns.xml sigProfiler_SBS_signatures_2019_05_22.tsv test-data/cosmic_output1.pdf test-data/denovo_1.RData test-data/denovo_output1.pdf test-data/sigmatrix.tab test-data/spectrum_output1.pdf |
| diffstat | 8 files changed, 388 insertions(+), 95 deletions(-) [+] |
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--- a/mutational_patterns.R Wed Sep 16 22:58:28 2020 +0000 +++ b/mutational_patterns.R Thu Sep 24 01:32:52 2020 +0000 @@ -29,6 +29,12 @@ help = "path to the tab separated file describing the levels in function of datasets" ), make_option( + "--cosmic_version", + default = "v2", + type = 'character', + help = "Version of the Cosmic Signature set to be used to express mutational patterns" + ), + make_option( "--signum", default = 2, type = 'integer', @@ -52,7 +58,6 @@ type = 'integer', help = "Number of new signatures to be captured" ), - make_option( "--output_spectrum", default = NA, @@ -66,11 +71,22 @@ help = "path to output dataset" ), make_option( + "--sigmatrix", + default = NA, + type = 'character', + help = "path to signature matrix" + ), + make_option( "--output_cosmic", default = NA, type = 'character', help = "path to output dataset" - ) + ), + make_option( + c("-r", "--rdata"), + type="character", + default=NULL, + help="Path to RData output file") ) opt = parse_args(OptionParser(option_list = option_list), @@ -81,28 +97,27 @@ parser <- newJSONParser() parser$addData(json_dict) fileslist <- parser$getObject() -vcf_files <- attr(fileslist, "names") -sample_names <- unname(unlist(fileslist)) +vcf_paths <- attr(fileslist, "names") +element_identifiers <- unname(unlist(fileslist)) ref_genome <- opt$genome -vcf_table <- data.frame(sample_name=sample_names, path=vcf_files) +vcf_table <- data.frame(element_identifier=element_identifiers, path=vcf_paths) library(MutationalPatterns) library(ref_genome, character.only = TRUE) +library(ggplot2) # Load the VCF files into a GRangesList: -vcfs <- read_vcfs_as_granges(vcf_files, sample_names, ref_genome) +vcfs <- read_vcfs_as_granges(vcf_paths, element_identifiers, ref_genome) if (!is.na(opt$levels)[1]) { # manage levels if there are - levels_table <- read.delim(opt$levels, header=FALSE, col.names=c("sample_name","level")) - library(dplyr) - metadata_table <- left_join(vcf_table, levels_table, by = "sample_name") -# detach("package:dplyr", unload=TRUE) - tissue <- metadata_table$level + levels_table <- read.delim(opt$levels, header=FALSE, col.names=c("element_identifier","level")) + library(plyr) + metadata_table <- join(vcf_table, levels_table, by = "element_identifier") + tissue <- as.vector(metadata_table$level) } ##### This is done for any section ###### mut_mat <- mut_matrix(vcf_list = vcfs, ref_genome = ref_genome) - ###### Section 1 Mutation characteristics and spectrums ############# if (!is.na(opt$output_spectrum)[1]) { pdf(opt$output_spectrum, paper = "special", width = 11.69, height = 11.69) @@ -114,34 +129,41 @@ p1 <- plot_spectrum(type_occurrences, CT = TRUE, legend=TRUE) plot(p1) } else { - p2 <- plot_spectrum(type_occurrences, by = tissue, CT=TRUE, legend=TRUE) # by sample + p2 <- plot_spectrum(type_occurrences, by = tissue, CT=TRUE) # by levels p3 <- plot_spectrum(type_occurrences, CT=TRUE, legend=TRUE) # total grid.arrange(p2, p3, ncol=2, widths=c(4,2.3), heights=c(4,1)) - } + } plot_96_profile(mut_mat, condensed = TRUE) dev.off() } ###### Section 2: De novo mutational signature extraction using NMF ####### if (!is.na(opt$output_denovo)[1]) { - mut_mat <- mut_mat + 0.0001 # First add a small psuedocount to the mutation count matrix + # opt$rank cannot be higher than the number of samples + if (opt$rank > length(element_identifiers)) {opt$rank <-length(element_identifiers)} + # likewise, opt$signum cannot be higher thant the number of samples + if (opt$signum > length(element_identifiers)) {opt$signum <-length(element_identifiers)} + pseudo_mut_mat <- mut_mat + 0.0001 # First add a small pseudocount to the mutation count matrix # Use the NMF package to generate an estimate rank plot library("NMF") - estimate <- nmf(mut_mat, rank=1:opt$rank+1, method="brunet", nrun=opt$nrun, seed=123456) + estimate <- nmf(pseudo_mut_mat, rank=1:opt$rank, method="brunet", nrun=opt$nrun, seed=123456) # And plot it pdf(opt$output_denovo, paper = "special", width = 11.69, height = 11.69) - p.trans <- plot(estimate) - grid.arrange(p.trans) + p4 <- plot(estimate) + grid.arrange(p4) # Extract 4 (PARAMETIZE) mutational signatures from the mutation count matrix with extract_signatures # (For larger datasets it is wise to perform more iterations by changing the nrun parameter # to achieve stability and avoid local minima) - nmf_res <- extract_signatures(mut_mat, rank=opt$rank, nrun=opt$nrun) + nmf_res <- extract_signatures(pseudo_mut_mat, rank=opt$newsignum, nrun=opt$nrun) # Assign signature names - colnames(nmf_res$signatures) <- paste0("NewSig_", 1:opt$rank) - rownames(nmf_res$contribution) <- paste0("NewSig_", 1:opt$rank) + colnames(nmf_res$signatures) <- paste0("NewSig_", 1:opt$newsignum) + rownames(nmf_res$contribution) <- paste0("NewSig_", 1:opt$newsignum) # Plot the 96-profile of the signatures: - p.trans <- plot_96_profile(nmf_res$signatures, condensed = TRUE) - grid.arrange(p.trans) + p5 <- plot_96_profile(nmf_res$signatures, condensed = TRUE) + new_sig_matrix <- reshape2::dcast(p5$data, substitution + context ~ variable, value.var = "value") + new_sig_matrix = format(new_sig_matrix, scientific=TRUE) + write.table(new_sig_matrix, file=opt$sigmatrix, quote = FALSE, row.names = FALSE, sep="\t") + grid.arrange(p5) # Visualize the contribution of the signatures in a barplot pc1 <- plot_contribution(nmf_res$contribution, nmf_res$signature, mode="relative", coord_flip = TRUE) # Visualize the contribution of the signatures in absolute number of mutations @@ -155,14 +177,14 @@ # can be plotted in a user-specified order. # Plot signature contribution as a heatmap with sample clustering dendrogram and a specified signature order: pch1 <- plot_contribution_heatmap(nmf_res$contribution, - sig_order = paste0("NewSig_", 1:opt$rank)) + sig_order = paste0("NewSig_", 1:opt$newsignum)) # Plot signature contribution as a heatmap without sample clustering: pch2 <- plot_contribution_heatmap(nmf_res$contribution, cluster_samples=FALSE) #Combine the plots into one figure: grid.arrange(pch1, pch2, ncol = 2, widths = c(2,1.6)) # Compare the reconstructed mutational profile with the original mutational profile: - plot_compare_profiles(mut_mat[,1], + plot_compare_profiles(pseudo_mut_mat[,1], nmf_res$reconstructed[,1], profile_names = c("Original", "Reconstructed"), condensed = TRUE) @@ -172,18 +194,38 @@ if (!is.na(opt$output_cosmic)[1]) { pdf(opt$output_cosmic, paper = "special", width = 11.69, height = 11.69) - sp_url <- paste("https://cancer.sanger.ac.uk/cancergenome/assets/", "signatures_probabilities.txt", sep = "") - cancer_signatures = read.table(sp_url, sep = "\t", header = TRUE) - mut_mat <- mut_mat + 0.0001 # First add a small psuedocount to the mutation count matrix - new_order = match(row.names(mut_mat), cancer_signatures$Somatic.Mutation.Type) - cancer_signatures = cancer_signatures[as.vector(new_order),] - row.names(cancer_signatures) = cancer_signatures$Somatic.Mutation.Type - cancer_signatures = as.matrix(cancer_signatures[,4:33]) + pseudo_mut_mat <- mut_mat + 0.0001 # First add a small psuedocount to the mutation count matrix + if (opt$cosmic_version == "v2") { + sp_url <- paste("https://cancer.sanger.ac.uk/cancergenome/assets/", "signatures_probabilities.txt", sep = "") + cancer_signatures = read.table(sp_url, sep = "\t", header = TRUE) + new_order = match(row.names(pseudo_mut_mat), cancer_signatures$Somatic.Mutation.Type) + cancer_signatures = cancer_signatures[as.vector(new_order),] + row.names(cancer_signatures) = cancer_signatures$Somatic.Mutation.Type + cancer_signatures = as.matrix(cancer_signatures[,4:33]) + colnames(cancer_signatures) <- gsub("Signature.", "", colnames(cancer_signatures)) # shorten signature labels + cosmic_tag <- "Signatures (Cosmic v2, March 2015)" + } else { + sp_url <- "https://raw.githubusercontent.com/ARTbio/startbio/master/sigProfiler_SBS_signatures_2019_05_22.tsv" + cancer_signatures = read.table(sp_url, sep = "\t", header = TRUE) + new_order = match(row.names(pseudo_mut_mat), cancer_signatures$Somatic.Mutation.Type) + cancer_signatures = cancer_signatures[as.vector(new_order),] + row.names(cancer_signatures) = cancer_signatures$Somatic.Mutation.Type + cancer_signatures = as.matrix(cancer_signatures[,4:70]) + colnames(cancer_signatures) <- gsub("SBS", "", colnames(cancer_signatures)) # shorten signature labels + cosmic_tag <- "Signatures (Cosmic v3, May 2019)" + } # Plot mutational profiles of the COSMIC signatures - colnames(cancer_signatures) <- gsub("Signature.", "", colnames(cancer_signatures)) # shorten signature labels - p.trans <- plot_96_profile(cancer_signatures, condensed = TRUE, ymax = 0.3) - grid.arrange(p.trans, top = textGrob("COSMIC signature profiles",gp=gpar(fontsize=12,font=3))) + if (opt$cosmic_version == "v2") { + p6 <- plot_96_profile(cancer_signatures, condensed = TRUE, ymax = 0.3) + grid.arrange(p6, top = textGrob("COSMIC signature profiles",gp=gpar(fontsize=12,font=3))) + } else { + print(length(cancer_signatures)) + p6 <- plot_96_profile(cancer_signatures[,1:33], condensed = TRUE, ymax = 0.3) + p6bis <- plot_96_profile(cancer_signatures[,34:67], condensed = TRUE, ymax = 0.3) + grid.arrange(p6, top = textGrob("COSMIC signature profiles (on two pages)",gp=gpar(fontsize=12,font=3))) + grid.arrange(p6bis, top = textGrob("COSMIC signature profiles (continued)",gp=gpar(fontsize=12,font=3))) + } # Hierarchically cluster the COSMIC signatures based on their similarity with average linkage # hclust_cosmic = cluster_signatures(cancer_signatures, method = "average") @@ -211,16 +253,37 @@ # grid.arrange(p.trans) # Find optimal contribution of COSMIC signatures to reconstruct 96 mutational profiles - fit_res <- fit_to_signatures(mut_mat, cancer_signatures) + fit_res <- fit_to_signatures(pseudo_mut_mat, cancer_signatures) # Select signatures with some contribution (above a threshold) threshold <- tail(sort(unlist(rowSums(fit_res$contribution), use.names = FALSE)), opt$signum)[1] select <- which(rowSums(fit_res$contribution) >= threshold) # ensure opt$signum best signatures in samples are retained, the others discarded # Plot contribution barplots - pc1 <- plot_contribution(fit_res$contribution[select,], cancer_signatures[,select], coord_flip = T, mode = "absolute") - pc2 <- plot_contribution(fit_res$contribution[select,], cancer_signatures[,select], coord_flip = T, mode = "relative") + pc3 <- plot_contribution(fit_res$contribution[select,], cancer_signatures[,select], coord_flip = T, mode = "absolute") + pc4 <- plot_contribution(fit_res$contribution[select,], cancer_signatures[,select], coord_flip = T, mode = "relative") + ##### + # ggplot2 alternative + if (!is.na(opt$levels)[1]) { # if there are levels to display in graphs + pc3_data <- pc3$data + pc3_data <- merge (pc3_data, metadata_table[,c(1,3)], by.x="Sample", by.y="element_identifier") + pc3 <- ggplot(pc3_data, aes(x=Sample, y=Contribution, fill=as.factor(Signature))) + + geom_bar(stat="identity", position='stack') + + scale_fill_discrete(name="Cosmic\nSignature") + + labs(x = "Samples", y = "Absolute contribution") + theme_bw() + + theme(panel.grid.minor.x = element_blank(), panel.grid.major.x = element_blank()) + + facet_grid(~level, scales = "free_x") + pc4_data <- pc4$data + pc4_data <- merge (pc4_data, metadata_table[,c(1,3)], by.x="Sample", by.y="element_identifier") + pc4 <- ggplot(pc4_data, aes(x=Sample, y=Contribution, fill=as.factor(Signature))) + + geom_bar(stat="identity", position='fill') + + scale_fill_discrete(name="Cosmic\nSignature") + + scale_y_continuous(labels = scales::percent_format(accuracy = 1)) + + labs(x = "Samples", y = "Relative contribution") + theme_bw() + + theme(panel.grid.minor.x = element_blank(), panel.grid.major.x = element_blank()) + + facet_grid(~level, scales = "free_x") + } # Combine the two plots: - grid.arrange(pc1, pc2) + grid.arrange(pc3, pc4, top = textGrob("Absolute and Relative Contributions of Cosmic signatures to mutational patterns",gp=gpar(fontsize=12,font=3))) ## pie charts of comic signatures contributions in samples sig_data_pie <- as.data.frame(t(head(fit_res$contribution[select,]))) @@ -231,20 +294,19 @@ melted_sig_data_pie_percents <-melt(data=sig_data_pie_percents) melted_sig_data_pie_percents$label <- sub("Sig.", "", melted_sig_data_pie_percents$variable) melted_sig_data_pie_percents$pos <- cumsum(melted_sig_data_pie_percents$value) - melted_sig_data_pie_percents$value/2 - library(ggplot2) - p.trans <- ggplot(melted_sig_data_pie_percents, aes(x="", y=value, group=variable, fill=variable)) + + p7 <- ggplot(melted_sig_data_pie_percents, aes(x="", y=value, group=variable, fill=variable)) + geom_bar(width = 1, stat = "identity") + geom_text(aes(label = label), position = position_stack(vjust = 0.5), color="black", size=3) + coord_polar("y", start=0) + facet_wrap(~ sample) + - labs(x="", y="Samples", fill = "Signatures (Cosmic_v2,March 2015)") + + labs(x="", y="Samples", fill = cosmic_tag) + theme(axis.text = element_blank(), axis.ticks = element_blank(), panel.grid = element_blank()) - grid.arrange(p.trans) + grid.arrange(p7) # Plot relative contribution of the cancer signatures in each sample as a heatmap with sample clustering - p.trans <- plot_contribution_heatmap(fit_res$contribution, cluster_samples = TRUE, method = "complete") - grid.arrange(p.trans) + p8 <- plot_contribution_heatmap(fit_res$contribution, cluster_samples = TRUE, method = "complete") + grid.arrange(p8) # Compare the reconstructed mutational profile of sample 1 with its original mutational profile # plot_compare_profiles(mut_mat[,1], fit_res$reconstructed[,1], @@ -255,7 +317,7 @@ # `cos_sim_matrix` # calculate all pairwise cosine similarities - cos_sim_ori_rec <- cos_sim_matrix(mut_mat, fit_res$reconstructed) + cos_sim_ori_rec <- cos_sim_matrix(pseudo_mut_mat, fit_res$reconstructed) # extract cosine similarities per sample between original and reconstructed cos_sim_ori_rec <- as.data.frame(diag(cos_sim_ori_rec)) @@ -270,7 +332,7 @@ colnames(cos_sim_ori_rec) = "cos_sim" cos_sim_ori_rec$sample = row.names(cos_sim_ori_rec) # Make barplot - p.trans <- ggplot(cos_sim_ori_rec, aes(y=cos_sim, x=sample)) + + p9 <- ggplot(cos_sim_ori_rec, aes(y=cos_sim, x=sample)) + geom_bar(stat="identity", fill = "skyblue4") + coord_cartesian(ylim=c(0.8, 1)) + # coord_flip(ylim=c(0.8,1)) + @@ -283,7 +345,12 @@ panel.grid.major.y=element_blank()) + # Add cut.off line geom_hline(aes(yintercept=.95)) - grid.arrange(p.trans, top = textGrob("Similarity between true and reconstructed profiles (with all Cosmic sig.)",gp=gpar(fontsize=12,font=3))) - + grid.arrange(p9, top = textGrob("Similarity between true and reconstructed profiles (with all Cosmic sig.)",gp=gpar(fontsize=12,font=3))) dev.off() } + + +# Output RData file +if (!is.null(opt$rdata)) { + save.image(file=opt$rdata) +}
--- a/mutational_patterns.xml Wed Sep 16 22:58:28 2020 +0000 +++ b/mutational_patterns.xml Thu Sep 24 01:32:52 2020 +0000 @@ -1,4 +1,4 @@ -<tool id="mutational_patterns" name="Analyse Mutational Patters/Signatures" version="2.0.0+galaxy3"> +<tool id="mutational_patterns" name="Analyse Mutational Patterns/Signatures" version="2.0.0+galaxy4"> <description>from genomic variations in vcf files</description> <requirements> <requirement type="package" version="2.0.0=r40_0">bioconductor-mutationalpatterns</requirement> @@ -43,13 +43,19 @@ --rank $set_denovo.rank --newsignum $set_denovo.newsignum --output_denovo $denovo + --sigmatrix $sigmatrix #end if #if $set_cosmic.choices == 'yes': + --cosmic_version $set_cosmic.cosmic_version --signum '$set_cosmic.signum' --output_cosmic $cosmic #end if + #if $rdata_out + --rdata '$rdata' + #end if + ]]></command> <inputs> <param name="vcfs" type="data_collection" format="vcf" label="VCF file(s) collection" multiple="true"/> @@ -90,6 +96,7 @@ <when value="yes" /> <when value="no" /> </conditional> + <conditional name="set_denovo"> <param name="choices" type="select" label="Extract de novo signatures with MutationalPatterns" display="radio"> <option value="yes" selected="true">Yes</option> @@ -101,10 +108,10 @@ help="High values extend the computational time"/> <param name="rank" type="integer" value="4" min="3" max="30" label="Number of ranks to be displayed for control of optimal number of signature" - help="High values extend the computational time"/> + help="High values extend the computational time. In addition the number of ranks cannot be greater than the number of available samples in the study"/> <param name="newsignum" type="integer" value="4" min="2" max="30" label="Number of de novo signatures to capture" - help="High values extend the computational time"/> + help="High values extend the computational time. Note also that you cannot extract more signature than the number of available samples in the study"/> </when> <when value="no" /> </conditional> @@ -118,9 +125,14 @@ <param name="signum" type="integer" value="3" min="2" max="30" label="selects the N most significant signatures in samples to express mutational patterns" help="an integer between 2 and 30 signature types from cosmic"/> + <param name="cosmic_version" type="select" label="Version of the Cosmic signature set"> + <option value="v2" selected="true">Cosmic v2, March 2015</option> + <option value="v3">Cosmic v3, May 2019</option> + </param> </when> <when value="no" /> - </conditional> + </conditional> + <param name="rdata_out" type="boolean" checked="false" label="Output RData file?" help="Output all the data used by R to construct the tables and plots, can be loaded into R" /> </inputs> <outputs> <data name="spectrum" format="pdf" label="Mutational Spectrum"> @@ -129,53 +141,19 @@ <data name="denovo" format="pdf" label="De novo signatures"> <filter>set_denovo['choices'] == "yes"</filter> </data> + <data name="sigmatrix" format="tabular" label="De novo signatures probability matrix"> + <filter>set_denovo['choices'] == "yes"</filter> + </data> <data name="cosmic" format="pdf" label="Cosmic signatures"> <filter>set_cosmic['choices'] == "yes"</filter> </data> + <data name="rdata" format="rdata" label="${tool.name}: RData file"> + <filter>rdata_out</filter> + </data> + </outputs> <tests> - <test> - <param name="vcfs"> - <collection type="list"> - <element name="1" ftype="vcf" value="G.vcf"/> - <element name="2" ftype="vcf" value="H.vcf"/> - </collection> - </param> - <param name="genome" value="BSgenome.Hsapiens.UCSC.hg38"/> - <param name="levels" value="GH_levels.tab" ftype="tabular"/> - <conditional name="set_spectrum"> - <param name="choices" value="no"/> - </conditional> - <conditional name="set_denovo"> - <param name="choices" value="no"/> - </conditional> - <conditional name="set_cosmic"> - <param name="choices" value="yes"/> - </conditional> - <param name="signum" value="3" /> - <output name="cosmic" file="cosmic_output1.pdf" compare="sim_size" ftype="pdf"/> - </test> - <test> - <param name="vcfs"> - <collection type="list"> - <element name="6" value="F.vcf"/> - <element name="7" value="G.vcf"/> - <element name="8" value="H.vcf"/> - <element name="9" value="I.vcf"/> - </collection> - </param> - <param name="genome" value="BSgenome.Hsapiens.UCSC.hg38"/> - <conditional name="set_spectrum"> - <param name="choices" value="no"/> - </conditional> - <conditional name="set_denovo"> - <param name="choices" value="yes"/> - </conditional> - <conditional name="set_cosmic"> - <param name="choices" value="no"/> - </conditional> - <output name="denovo" file="denovo_output1.pdf" compare="sim_size" ftype="pdf"/> - </test> + <!-- simple profile --> <test> <param name="vcfs"> <collection type="list"> @@ -199,6 +177,60 @@ </conditional> <output name="spectrum" file="spectrum_output1.pdf" compare="sim_size" ftype="pdf"/> </test> + + <!-- de novo signatures --> + <test> + <param name="vcfs"> + <collection type="list"> + <element name="6" value="F.vcf"/> + <element name="7" value="G.vcf"/> + <element name="8" value="H.vcf"/> + <element name="9" value="I.vcf"/> + </collection> + </param> + <param name="genome" value="BSgenome.Hsapiens.UCSC.hg38"/> + <conditional name="set_spectrum"> + <param name="choices" value="no"/> + </conditional> + <conditional name="set_denovo"> + <param name="choices" value="yes"/> + </conditional> + <conditional name="set_cosmic"> + <param name="choices" value="no"/> + </conditional> + <param name="nrun" value="10" /> + <param name="rank" value="4" /> + <param name="newsignum" value="4" /> + <param name="rdata_out" value="true" /> + <output name="denovo" file="denovo_output1.pdf" compare="sim_size" ftype="pdf"/> + <output name="sigmatrix" file="sigmatrix.tab" ftype="tabular" compare="sim_size"/> + <output name="rdata" file="denovo_1.RData" compare="sim_size" delta="400000"/> <!-- delta="170000" --> + </test> + + <!-- cosmic signatures --> + <test> + <param name="vcfs"> + <collection type="list"> + <element name="6" value="F.vcf"/> + <element name="7" value="G.vcf"/> + <element name="8" value="H.vcf"/> + <element name="9" value="I.vcf"/> + </collection> + </param> + <param name="genome" value="BSgenome.Hsapiens.UCSC.hg38"/> + <param name="levels" value="GH_levels.tab" ftype="tabular"/> + <conditional name="set_spectrum"> + <param name="choices" value="no"/> + </conditional> + <conditional name="set_denovo"> + <param name="choices" value="no"/> + </conditional> + <conditional name="set_cosmic"> + <param name="choices" value="yes"/> + </conditional> + <param name="signum" value="3" /> + <output name="cosmic" file="cosmic_output1.pdf" compare="sim_size" ftype="pdf"/> + </test> </tests> <help>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/sigProfiler_SBS_signatures_2019_05_22.tsv Thu Sep 24 01:32:52 2020 +0000 @@ -0,0 +1,97 @@ +Type SubType Somatic Mutation Type SBS1 SBS2 SBS3 SBS4 SBS5 SBS6 SBS7a SBS7b SBS7c SBS7d SBS8 SBS9 SBS10a SBS10b SBS11 SBS12 SBS13 SBS14 SBS15 SBS16 SBS17a SBS17b SBS18 SBS19 SBS20 SBS21 SBS22 SBS23 SBS24 SBS25 SBS26 SBS27 SBS28 SBS29 SBS30 SBS31 SBS32 SBS33 SBS34 SBS35 SBS36 SBS37 SBS38 SBS39 SBS40 SBS41 SBS42 SBS43 SBS44 SBS45 SBS46 SBS47 SBS48 SBS49 SBS50 SBS51 SBS52 SBS53 SBS54 SBS55 SBS56 SBS57 SBS58 SBS59 SBS60 SBS84 SBS85 +C>A ACA A[C>A]A 8.86E-04 5.80E-07 2.08E-02 4.22E-02 1.20E-02 4.25E-04 6.70E-05 2.33E-03 4.83E-03 4.04E-05 4.41E-02 5.58E-04 2.19E-03 1.82E-04 1.46E-04 4.52E-03 1.82E-03 1.12E-03 9.44E-04 1.60E-02 2.07E-03 6.08E-04 5.15E-02 1.27E-03 6.19E-04 1.57E-04 6.01E-03 8.35E-04 3.64E-02 9.90E-03 8.73E-04 5.21E-03 7.84E-04 6.32E-02 1.80E-03 9.54E-03 2.23E-02 3.11E-03 4.87E-03 8.83E-03 2.52E-02 3.95E-03 1.28E-02 1.17E-02 2.82E-02 2.11E-03 1.16E-03 2.95E-02 7.68E-18 9.11E-03 4.40E-03 6.78E-02 8.55E-04 2.51E-02 1.19E-01 1.41E-01 1.52E-02 5.38E-03 2.16E-03 5.88E-03 1.26E-02 1.23E-02 5.89E-02 3.59E-03 6.15E-03 0.003471994832 0.006080257390 +C>A ACC A[C>A]C 2.28E-03 1.48E-04 1.65E-02 3.33E-02 9.44E-03 5.24E-04 1.79E-04 4.61E-04 1.15E-03 7.65E-04 4.78E-02 4.09E-03 1.77E-03 6.54E-03 5.52E-04 1.13E-03 7.21E-04 1.31E-02 4.97E-04 2.90E-03 9.18E-04 1.29E-04 1.58E-02 6.41E-04 1.39E-03 2.36E-03 9.54E-05 3.99E-04 2.65E-02 7.00E-03 5.28E-04 4.74E-03 2.53E-03 5.12E-02 5.06E-04 1.85E-02 1.88E-02 2.23E-03 6.96E-03 4.62E-02 8.32E-03 1.45E-03 1.01E-02 7.15E-03 1.34E-02 1.22E-03 2.06E-02 5.90E-03 1.50E-04 2.85E-03 4.70E-03 2.97E-02 8.41E-04 7.03E-03 1.27E-01 1.69E-03 6.54E-03 1.96E-03 7.96E-04 2.05E-03 1.57E-02 1.43E-03 6.75E-03 2.37E-03 7.79E-04 0.005007308997 0.000879936873 +C>A ACG A[C>A]G 1.77E-04 5.23E-05 1.75E-03 1.56E-02 1.85E-03 5.20E-05 7.12E-05 1.86E-04 3.77E-04 2.50E-04 4.62E-03 4.26E-04 1.50E-04 5.35E-05 9.41E-05 5.40E-04 2.64E-04 4.13E-04 4.61E-05 1.02E-03 4.76E-05 5.82E-05 2.43E-03 2.46E-04 2.18E-05 2.94E-04 7.65E-04 9.85E-08 1.48E-02 1.45E-03 1.14E-04 7.83E-04 3.53E-04 1.92E-02 9.13E-05 1.66E-03 4.46E-03 4.14E-04 5.20E-05 1.39E-03 2.24E-03 1.06E-03 1.90E-03 2.67E-03 2.92E-03 6.14E-05 3.34E-05 6.26E-04 9.16E-07 1.66E-03 3.00E-04 1.38E-03 2.58E-04 7.11E-03 5.77E-03 4.80E-03 4.14E-03 3.81E-02 1.64E-03 4.49E-05 2.06E-04 3.33E-03 8.25E-04 1.42E-04 2.23E-16 0.000452641972 0.000306011349 +C>A ACT A[C>A]T 1.28E-03 9.78E-05 1.22E-02 2.95E-02 6.61E-03 1.80E-04 2.48E-04 7.10E-04 1.96E-03 4.05E-03 4.70E-02 3.05E-03 1.70E-02 1.63E-05 2.66E-04 1.22E-03 3.48E-04 8.26E-02 1.11E-03 1.06E-02 6.18E-05 4.56E-04 2.14E-02 5.71E-04 1.24E-03 6.21E-04 1.72E-03 5.61E-18 2.20E-02 4.97E-03 6.19E-04 2.72E-03 3.97E-03 3.56E-02 5.56E-04 6.28E-03 1.46E-02 1.90E-03 1.23E-03 2.16E-02 1.79E-02 1.85E-03 8.85E-03 7.40E-03 1.48E-02 1.33E-03 7.97E-03 2.07E-03 5.78E-03 9.64E-03 3.40E-03 1.19E-02 3.89E-05 7.97E-03 8.32E-02 2.12E-02 9.24E-03 1.71E-05 4.14E-04 1.17E-03 2.30E-02 8.64E-03 5.58E-03 1.45E-02 4.44E-04 0.009295948365 0.002717279233 +C>A CCA C[C>A]A 3.12E-04 2.08E-04 2.25E-02 8.07E-02 7.43E-03 1.82E-03 4.55E-04 1.14E-03 1.09E-04 1.45E-02 4.01E-02 4.80E-03 3.18E-03 5.21E-04 6.18E-04 5.42E-03 1.40E-03 1.63E-02 4.18E-02 1.04E-02 2.95E-04 2.71E-04 7.40E-02 1.32E-03 3.76E-02 2.22E-16 1.83E-03 1.51E-04 2.54E-02 1.48E-02 1.41E-03 5.07E-03 2.03E-03 5.42E-02 7.68E-04 1.07E-02 1.24E-03 2.70E-03 1.95E-03 2.99E-02 5.58E-02 3.22E-03 3.81E-01 1.01E-02 2.08E-02 2.38E-03 1.16E-02 6.63E-03 2.84E-05 2.38E-01 1.56E-02 2.46E-02 1.18E-03 2.29E-01 2.25E-02 6.98E-03 5.74E-02 3.34E-01 6.32E-05 6.25E-03 2.48E-03 8.70E-03 6.18E-03 2.23E-03 1.18E-03 0.000000000000 0.004264235123 +C>A CCC C[C>A]C 1.79E-03 9.53E-05 2.53E-02 7.97E-02 6.14E-03 4.09E-03 2.40E-04 1.55E-03 3.09E-03 3.22E-03 3.88E-02 1.92E-03 2.02E-04 3.18E-03 9.86E-04 4.28E-03 9.68E-04 1.97E-02 5.05E-03 9.03E-03 1.16E-03 4.11E-05 1.96E-02 7.67E-04 9.89E-02 2.60E-03 4.43E-03 6.30E-04 3.49E-02 7.82E-03 1.51E-03 2.23E-03 1.09E-04 3.69E-02 3.88E-04 1.16E-02 4.92E-03 1.91E-03 3.67E-05 3.30E-02 2.02E-02 8.14E-04 6.95E-02 9.06E-03 1.47E-02 9.19E-04 3.28E-02 8.20E-05 3.03E-02 1.51E-01 7.20E-03 5.27E-03 3.57E-05 2.86E-02 2.89E-03 3.17E-03 1.90E-02 3.55E-03 2.57E-03 3.75E-03 6.68E-03 3.94E-03 1.83E-03 5.93E-03 2.53E-04 0.005218571801 0.000306234865 +C>A CCG C[C>A]G 9.32E-05 2.23E-16 2.51E-03 2.45E-02 3.46E-03 1.65E-03 2.23E-16 4.08E-04 1.91E-03 8.51E-05 3.41E-03 1.37E-03 4.64E-05 8.38E-05 9.20E-06 1.17E-03 4.33E-06 1.38E-03 6.62E-05 1.74E-03 2.22E-16 2.23E-16 1.20E-02 2.36E-04 7.43E-03 1.98E-03 1.36E-04 1.30E-04 1.60E-02 1.28E-03 3.62E-04 2.66E-04 2.22E-16 1.48E-02 4.07E-04 3.29E-04 1.66E-05 3.71E-04 2.98E-04 2.20E-03 7.10E-03 7.47E-04 5.10E-02 5.74E-03 2.54E-03 2.61E-04 1.88E-03 2.56E-05 3.74E-03 6.79E-02 4.50E-03 2.71E-04 1.37E-01 5.15E-01 5.18E-18 4.30E-03 1.36E-02 6.77E-02 5.93E-03 6.41E-04 6.72E-18 1.07E-03 1.46E-03 8.15E-04 3.79E-04 0.000069231298 0.000157256840 +C>A CCT C[C>A]T 2.23E-16 4.21E-04 1.54E-02 6.90E-02 6.49E-03 9.60E-03 3.72E-04 1.49E-03 1.35E-02 1.17E-04 3.30E-02 3.06E-03 1.73E-02 8.33E-03 1.50E-04 1.10E-03 2.22E-16 2.60E-01 2.87E-02 2.49E-03 1.37E-04 1.82E-04 3.63E-02 3.44E-05 2.52E-01 1.91E-02 1.10E-04 5.80E-04 1.71E-02 1.26E-02 7.14E-03 3.10E-03 2.03E-04 5.19E-02 2.97E-04 2.79E-02 2.67E-03 2.53E-03 6.20E-04 8.25E-02 6.05E-02 1.77E-03 1.84E-01 6.03E-03 1.47E-02 2.65E-03 2.11E-02 5.22E-18 8.67E-02 1.94E-01 8.30E-03 6.82E-04 8.45E-04 4.90E-02 1.15E-03 5.07E-03 1.88E-02 4.92E-03 5.53E-03 2.84E-05 7.13E-02 8.21E-03 1.96E-03 2.02E-03 5.41E-05 0.005640381180 0.000860850681 +C>A GCA G[C>A]A 1.58E-03 8.62E-05 7.13E-03 3.16E-02 1.02E-02 4.27E-04 4.06E-05 7.46E-04 1.05E-03 1.68E-04 2.42E-02 7.72E-03 1.21E-03 7.31E-04 1.65E-04 1.98E-03 9.49E-04 2.08E-03 2.29E-03 8.61E-03 1.78E-03 9.98E-04 1.09E-01 8.14E-04 1.08E-02 2.14E-03 2.23E-03 3.37E-04 6.22E-02 1.35E-02 4.96E-04 1.08E-02 1.56E-04 9.71E-02 9.43E-04 1.31E-02 4.51E-03 4.41E-03 2.81E-03 9.87E-03 6.77E-02 2.04E-03 1.20E-02 6.88E-03 1.42E-02 3.09E-03 7.71E-03 9.30E-03 7.68E-18 7.55E-03 7.20E-03 1.11E-02 7.52E-04 7.88E-03 1.42E-02 3.94E-03 8.24E-03 4.32E-04 5.19E-03 8.55E-04 2.17E-04 1.89E-03 2.74E-03 1.03E-01 5.17E-04 0.002703472389 0.001439703098 +C>A GCC G[C>A]C 3.39E-04 2.23E-16 1.09E-02 3.48E-02 7.65E-03 9.13E-04 1.38E-04 2.15E-04 7.42E-04 2.22E-16 2.62E-02 6.68E-03 4.41E-04 2.55E-03 4.05E-04 4.17E-04 4.51E-04 2.24E-02 2.49E-03 4.25E-03 1.28E-03 2.78E-06 1.73E-02 2.72E-04 5.65E-03 7.07E-03 1.73E-03 5.41E-04 1.28E-01 6.47E-03 6.66E-04 1.24E-02 1.02E-03 9.03E-02 4.94E-04 2.15E-02 3.62E-03 9.68E-04 4.68E-04 5.02E-02 1.92E-02 6.29E-04 6.28E-03 6.95E-03 1.02E-02 7.23E-04 2.68E-02 1.69E-03 4.67E-03 5.73E-03 3.00E-03 3.48E-03 3.46E-04 2.48E-03 7.58E-03 3.28E-03 7.32E-03 3.44E-03 9.13E-03 1.92E-04 7.34E-03 7.52E-04 1.08E-03 1.29E-01 8.66E-04 0.010228858800 0.000504268015 +C>A GCG G[C>A]G 5.87E-04 1.39E-05 1.43E-03 1.53E-02 2.34E-03 3.57E-04 4.25E-05 7.29E-05 2.22E-16 1.82E-05 2.74E-03 1.71E-04 1.05E-05 8.52E-05 1.39E-05 4.47E-04 1.64E-04 1.11E-03 4.04E-04 1.36E-03 1.06E-04 9.24E-05 7.56E-03 2.05E-04 1.57E-03 1.69E-03 5.15E-04 1.19E-04 6.59E-02 6.58E-04 1.29E-04 1.63E-03 3.95E-05 2.30E-02 2.22E-16 9.72E-04 8.77E-04 3.42E-04 2.27E-04 5.07E-04 4.83E-03 5.06E-04 1.37E-03 4.53E-03 2.55E-03 2.20E-04 1.06E-03 1.77E-04 6.05E-04 2.09E-03 4.00E-04 7.83E-04 7.39E-04 6.83E-03 2.44E-04 4.28E-03 4.04E-03 5.08E-02 5.64E-03 7.72E-05 9.79E-06 6.57E-18 2.73E-03 1.21E-02 3.90E-04 0.000763601342 0.000362282705 +C>A GCT G[C>A]T 2.23E-16 5.12E-05 1.00E-02 2.12E-02 6.82E-03 1.23E-03 2.23E-16 1.47E-04 3.63E-04 7.40E-05 2.69E-02 8.56E-03 1.11E-02 2.80E-03 2.22E-16 2.75E-05 6.15E-05 1.26E-01 1.82E-02 5.80E-03 4.70E-05 5.34E-04 6.23E-02 2.73E-04 2.49E-03 8.90E-03 5.51E-04 3.09E-05 5.44E-02 1.05E-02 8.17E-04 7.41E-03 1.58E-04 8.46E-02 8.62E-04 3.51E-03 3.27E-03 3.19E-03 1.35E-05 2.29E-02 6.90E-02 1.29E-03 9.09E-03 5.89E-03 1.08E-02 1.95E-03 1.81E-02 1.39E-03 1.13E-02 6.99E-03 2.40E-03 1.41E-03 1.99E-05 5.84E-03 2.04E-03 3.45E-03 4.21E-03 1.14E-03 6.73E-03 7.38E-04 1.57E-02 1.95E-03 3.50E-04 4.99E-01 1.33E-04 0.010179165989 0.000762947056 +C>A TCA T[C>A]A 6.58E-05 6.39E-04 8.41E-03 3.98E-02 7.86E-03 3.56E-04 3.90E-04 2.90E-03 2.52E-03 1.14E-02 2.98E-02 1.70E-02 9.40E-02 4.46E-04 1.80E-04 3.48E-03 7.90E-02 3.47E-04 1.72E-02 1.08E-02 1.90E-04 1.24E-05 7.38E-02 1.38E-03 1.71E-03 1.46E-03 7.84E-04 2.13E-03 2.98E-02 6.94E-03 9.38E-04 7.08E-03 1.43E-02 4.52E-02 6.96E-04 1.86E-03 9.73E-03 1.19E-02 4.27E-03 5.27E-03 1.41E-01 2.00E-03 1.77E-02 5.98E-03 2.60E-02 3.31E-03 5.10E-03 6.30E-03 8.53E-04 6.40E-02 1.23E-02 1.69E-02 1.24E-01 3.29E-02 1.90E-02 3.57E-02 4.64E-01 2.67E-03 6.69E-04 1.74E-03 2.19E-01 1.43E-02 7.37E-03 2.37E-05 2.02E-03 0.002083564327 0.001944387330 +C>A TCC T[C>A]C 2.53E-03 1.70E-04 1.68E-02 4.69E-02 9.17E-03 4.98E-04 6.36E-04 3.52E-03 1.42E-02 7.76E-03 2.51E-02 2.46E-03 9.97E-03 3.80E-03 9.38E-04 2.88E-03 2.94E-02 2.43E-02 5.81E-03 5.87E-03 2.59E-05 2.23E-16 4.36E-02 1.13E-03 3.37E-03 2.36E-04 1.74E-03 6.64E-04 5.19E-02 1.02E-02 6.30E-04 6.27E-03 4.52E-04 4.11E-02 2.43E-04 9.38E-03 9.29E-03 5.11E-03 1.22E-03 2.31E-02 7.72E-02 1.59E-03 1.15E-02 7.86E-03 2.10E-02 1.72E-03 5.40E-02 5.37E-06 2.22E-03 6.42E-02 7.10E-03 8.11E-05 3.79E-03 5.11E-03 8.86E-04 2.86E-03 4.68E-02 3.64E-03 4.05E-05 8.28E-18 1.32E-02 7.09E-04 4.29E-04 2.02E-02 1.63E-04 0.000009064386 0.000169427568 +C>A TCG T[C>A]G 2.23E-16 8.53E-05 1.41E-03 1.09E-02 2.30E-03 2.00E-04 3.44E-05 3.00E-04 2.22E-16 2.22E-16 1.90E-03 4.45E-04 1.16E-03 5.73E-04 2.22E-16 5.05E-04 1.21E-02 7.08E-06 7.69E-05 1.49E-03 2.22E-16 9.51E-05 1.27E-02 2.85E-04 2.22E-16 6.83E-05 2.22E-16 9.12E-05 9.79E-03 0.00E+00 1.23E-04 1.45E-03 1.29E-04 1.74E-02 8.26E-05 9.55E-04 2.38E-03 1.37E-03 2.22E-16 9.47E-05 1.47E-02 1.12E-03 2.38E-03 3.01E-03 3.17E-03 2.07E-04 9.04E-04 3.07E-18 3.15E-07 1.83E-02 2.50E-03 2.39E-05 7.09E-01 4.05E-02 4.19E-05 4.54E-03 1.34E-01 4.47E-04 8.28E-04 9.91E-05 5.46E-03 2.23E-04 2.73E-03 6.34E-04 2.05E-04 0.000000000000 0.000000003989 +C>A TCT T[C>A]T 5.88E-06 4.40E-04 9.97E-03 4.13E-02 1.27E-02 7.47E-04 6.13E-04 1.41E-03 3.73E-03 1.91E-04 3.19E-02 2.73E-02 6.70E-01 8.16E-02 4.73E-05 2.35E-03 3.55E-02 1.51E-01 8.05E-03 9.25E-03 2.88E-04 2.57E-03 1.22E-01 1.38E-03 9.04E-04 2.22E-16 3.96E-04 2.40E-04 2.28E-02 2.46E-02 1.40E-03 9.81E-03 5.57E-04 4.11E-02 6.65E-04 4.49E-03 9.64E-03 1.28E-02 3.20E-05 1.53E-02 2.08E-01 2.44E-03 2.78E-02 6.55E-03 2.41E-02 5.90E-03 2.73E-02 6.52E-18 1.66E-02 6.20E-02 3.00E-03 1.92E-04 1.87E-04 8.75E-03 1.85E-03 3.70E-04 6.10E-02 8.71E-04 7.20E-03 4.06E-03 4.02E-01 6.19E-03 1.47E-02 3.83E-03 4.06E-04 0.001203779266 0.002057492391 +C>G ACA A[C>G]A 1.86E-03 2.23E-16 1.97E-02 6.89E-03 1.01E-02 4.71E-04 6.49E-05 8.56E-06 1.12E-03 1.18E-03 4.33E-03 4.84E-03 2.23E-16 3.05E-04 1.70E-04 1.22E-03 3.87E-03 2.22E-16 1.13E-04 1.74E-03 1.01E-03 1.46E-04 1.73E-03 3.19E-03 8.77E-03 1.69E-05 1.66E-03 5.74E-18 3.34E-03 8.03E-03 4.27E-04 1.32E-03 1.54E-04 3.14E-03 1.07E-03 8.32E-03 1.99E-03 1.41E-03 7.62E-04 3.58E-03 1.84E-03 3.43E-02 2.69E-03 4.73E-02 1.22E-02 5.33E-03 4.06E-04 3.61E-04 3.18E-03 3.11E-03 1.20E-03 1.03E-03 1.98E-04 2.88E-04 3.85E-03 3.96E-03 1.73E-03 7.03E-03 1.55E-03 2.85E-03 4.18E-04 1.54E-02 2.06E-02 2.94E-03 3.77E-04 0.006758077485 0.007234927130 +C>G ACC A[C>G]C 1.22E-03 1.33E-04 1.17E-02 2.84E-03 5.70E-03 2.89E-04 2.16E-05 1.89E-04 3.19E-04 2.55E-03 2.95E-03 1.96E-03 2.43E-05 1.34E-04 2.90E-04 6.42E-04 9.51E-04 5.78E-06 2.69E-04 2.01E-03 5.69E-04 4.34E-05 2.59E-03 1.79E-03 1.51E-03 7.19E-04 1.95E-04 4.08E-05 3.67E-03 1.64E-03 3.78E-04 1.77E-03 2.24E-04 2.63E-03 4.67E-04 3.16E-03 2.03E-03 1.30E-03 1.13E-03 4.55E-03 1.67E-03 1.12E-02 1.58E-03 2.25E-02 8.68E-03 3.16E-03 5.06E-04 3.13E-05 2.33E-04 1.93E-03 1.50E-03 6.17E-04 1.14E-04 1.35E-04 1.10E-03 4.54E-03 1.52E-03 5.46E-03 4.96E-04 1.68E-04 1.66E-04 3.13E-03 1.74E-03 2.44E-03 5.88E-04 0.010811956859 0.002551355408 +C>G ACG A[C>G]G 1.15E-04 1.52E-05 2.53E-04 1.28E-03 1.72E-03 2.22E-16 5.08E-05 5.05E-04 2.22E-16 9.06E-04 2.86E-04 1.36E-03 2.23E-16 2.22E-16 5.96E-05 7.51E-05 2.64E-04 3.91E-05 3.07E-05 8.47E-04 1.52E-04 2.23E-16 1.92E-03 6.16E-04 4.69E-04 2.22E-16 2.31E-04 2.86E-18 9.20E-04 0.00E+00 6.83E-05 0.00E+00 2.22E-16 8.96E-04 1.31E-04 3.00E-03 1.13E-03 2.53E-04 2.22E-16 3.46E-04 5.00E-04 5.35E-03 6.36E-04 1.36E-02 2.25E-03 1.21E-03 1.77E-05 4.43E-03 3.14E-05 2.70E-04 0.00E+00 3.28E-04 8.03E-05 2.04E-04 8.27E-04 1.97E-03 8.18E-04 2.51E-03 1.70E-03 5.10E-04 4.28E-04 2.77E-03 1.69E-03 8.30E-04 2.76E-04 0.000045986523 0.000422196736 +C>G ACT A[C>G]T 1.14E-03 9.12E-05 1.74E-02 3.55E-03 1.01E-02 2.54E-04 9.56E-05 2.85E-04 1.93E-03 2.91E-03 5.71E-03 6.41E-03 2.23E-16 2.22E-16 5.35E-04 1.44E-03 4.00E-03 2.04E-04 3.25E-04 1.15E-02 1.96E-05 3.19E-04 4.08E-03 2.14E-03 4.42E-03 6.19E-05 6.20E-05 5.61E-18 2.85E-03 3.43E-03 7.28E-04 1.32E-03 8.33E-05 2.49E-03 7.31E-04 3.78E-03 1.75E-03 1.30E-03 2.03E-03 9.48E-03 1.91E-03 1.88E-02 2.44E-03 4.34E-02 1.46E-02 8.27E-03 4.31E-04 3.54E-04 3.29E-03 1.43E-03 2.20E-03 1.72E-03 6.86E-04 1.76E-04 1.97E-03 9.00E-04 1.71E-03 3.04E-03 5.18E-03 1.27E-03 1.23E-04 5.07E-03 2.03E-03 3.83E-03 2.50E-04 0.029594216358 0.013019760586 +C>G CCA C[C>G]A 2.41E-05 2.23E-16 1.93E-02 7.83E-03 6.96E-03 4.11E-05 2.23E-16 4.58E-04 2.06E-04 1.32E-03 5.00E-03 8.93E-04 4.57E-05 2.99E-05 2.61E-04 1.34E-03 5.61E-03 8.55E-05 8.36E-05 3.55E-03 5.53E-04 1.94E-04 6.13E-04 1.77E-03 7.69E-05 1.97E-05 1.05E-03 1.74E-04 2.61E-03 7.20E-03 3.64E-04 4.73E-03 1.44E-05 3.29E-03 1.27E-03 2.05E-03 1.15E-03 1.50E-03 1.19E-04 3.86E-03 1.24E-03 4.42E-04 1.69E-03 2.88E-02 7.56E-03 2.08E-03 4.26E-03 2.09E-05 5.36E-05 1.43E-03 5.00E-04 9.56E-04 9.93E-05 2.16E-04 6.56E-05 2.85E-03 1.18E-03 2.72E-03 1.13E-03 2.94E-03 2.04E-04 8.88E-04 7.94E-04 2.08E-03 4.71E-05 0.000007117033 0.001223945047 +C>G CCC C[C>G]C 7.68E-05 3.51E-04 1.41E-02 6.87E-03 9.07E-03 3.72E-05 1.31E-04 9.60E-04 2.26E-03 2.86E-04 5.46E-03 1.54E-03 2.23E-16 2.22E-16 1.77E-04 8.91E-04 6.48E-04 7.86E-05 1.70E-05 4.54E-03 2.35E-04 4.66E-05 2.26E-03 1.81E-03 4.38E-06 2.73E-04 7.85E-04 2.55E-04 5.22E-03 4.60E-03 3.22E-04 1.26E-03 7.55E-05 6.34E-03 7.93E-04 1.86E-03 8.24E-04 4.10E-04 1.18E-04 6.30E-03 1.37E-03 3.13E-04 1.26E-03 3.77E-02 9.35E-03 1.20E-03 6.62E-03 2.12E-04 2.49E-05 8.00E-04 3.00E-04 2.37E-04 1.22E-04 2.56E-04 2.89E-04 1.20E-04 8.35E-04 6.03E-03 8.83E-04 2.86E-03 2.25E-04 2.87E-03 1.28E-03 1.73E-03 1.42E-04 0.003440786012 0.000210178860 +C>G CCG C[C>G]G 3.52E-04 4.87E-05 1.50E-03 3.40E-03 2.49E-03 8.43E-05 7.75E-05 7.91E-04 2.62E-04 1.32E-03 1.05E-05 4.37E-04 2.01E-05 2.22E-16 1.12E-05 1.73E-04 4.88E-04 1.91E-05 5.02E-05 1.46E-03 2.32E-04 2.23E-16 3.58E-03 4.81E-05 1.88E-04 1.01E-05 2.39E-04 1.86E-18 9.45E-04 8.24E-04 4.17E-05 3.61E-04 2.22E-16 1.30E-03 1.20E-04 8.54E-04 5.37E-04 3.18E-04 1.90E-04 8.70E-04 4.19E-04 3.21E-04 9.57E-04 1.23E-02 1.68E-03 4.11E-04 4.70E-04 2.54E-03 7.68E-18 6.43E-04 1.00E-04 6.70E-04 3.63E-05 2.38E-04 1.42E-03 2.03E-03 5.68E-04 1.62E-03 4.34E-04 2.64E-04 6.66E-05 7.63E-04 5.11E-05 6.90E-04 3.37E-04 0.000002195949 0.000040247509 +C>G CCT C[C>G]T 2.23E-16 6.36E-05 2.23E-02 6.82E-03 9.53E-03 1.44E-05 9.56E-05 8.90E-04 4.24E-03 2.22E-16 5.49E-03 3.03E-03 3.01E-05 2.22E-16 9.64E-06 1.56E-03 6.40E-03 1.78E-04 8.45E-05 9.62E-03 3.90E-05 1.93E-04 3.79E-03 3.22E-03 1.01E-05 1.73E-04 3.20E-04 2.27E-04 4.71E-03 1.96E-04 6.25E-04 2.68E-04 2.22E-16 6.69E-03 1.02E-03 3.42E-03 4.95E-04 6.62E-04 7.36E-05 1.62E-02 2.09E-03 5.81E-04 1.27E-03 4.02E-02 1.39E-02 5.03E-03 6.84E-03 8.53E-04 8.64E-05 1.91E-03 1.50E-03 1.37E-04 2.45E-04 1.91E-04 5.12E-04 2.61E-03 1.20E-03 5.08E-04 1.33E-03 3.31E-03 7.69E-04 2.87E-03 1.25E-03 3.46E-03 1.46E-04 0.013308248775 0.000484083725 +C>G GCA G[C>G]A 9.59E-06 6.54E-05 1.27E-02 5.29E-03 4.68E-03 1.94E-05 1.96E-05 5.11E-05 1.82E-04 1.96E-04 2.58E-03 1.36E-03 1.50E-05 1.72E-05 4.67E-05 5.64E-04 1.50E-03 2.22E-16 9.94E-04 1.05E-03 8.78E-04 5.99E-05 6.35E-04 1.31E-03 6.69E-04 3.88E-04 1.40E-03 4.32E-18 2.72E-03 4.17E-03 3.95E-04 1.42E-03 1.83E-04 2.27E-03 5.15E-04 1.83E-03 8.76E-04 7.71E-04 3.34E-05 3.38E-03 8.86E-04 1.32E-03 1.20E-03 2.40E-02 5.06E-03 2.04E-03 2.40E-03 1.36E-02 2.19E-04 3.33E-04 1.00E-04 1.68E-03 7.84E-05 1.52E-04 2.67E-02 3.41E-03 1.38E-03 1.38E-03 2.19E-03 8.51E-04 1.87E-04 3.79E-03 2.12E-03 1.44E-03 1.63E-04 0.011151059622 0.001595924101 +C>G GCC G[C>G]C 1.64E-04 2.61E-04 8.63E-03 5.75E-03 5.08E-03 6.85E-04 3.32E-05 4.52E-04 4.73E-04 2.22E-16 2.39E-03 2.83E-03 8.31E-05 1.36E-04 1.14E-04 2.89E-04 4.79E-04 4.33E-05 6.08E-04 3.09E-03 8.35E-04 5.55E-05 1.34E-03 1.29E-03 2.86E-03 1.42E-03 9.30E-04 1.27E-04 5.79E-03 2.39E-03 5.79E-04 1.35E-03 2.22E-16 1.64E-03 2.56E-04 7.51E-03 9.00E-04 7.76E-04 1.93E-04 2.14E-02 1.08E-03 9.38E-04 1.08E-03 2.13E-02 5.37E-03 2.69E-03 1.42E-03 1.52E-02 1.19E-03 1.01E-03 8.00E-04 2.28E-03 2.17E-04 1.10E-04 3.30E-02 1.14E-03 1.45E-03 8.47E-02 2.20E-04 1.41E-03 9.83E-05 2.57E-03 1.49E-03 1.72E-03 1.35E-04 0.015758341831 0.005060362002 +C>G GCG G[C>G]G 1.66E-04 2.23E-16 2.42E-03 3.30E-03 1.51E-03 2.22E-16 4.51E-05 3.37E-04 1.80E-04 5.45E-04 4.88E-04 5.21E-04 2.23E-16 2.22E-16 3.24E-06 9.54E-05 2.41E-04 2.22E-16 1.01E-05 8.13E-05 2.37E-05 2.23E-16 6.39E-04 5.97E-04 6.92E-04 1.17E-04 2.11E-04 1.83E-18 3.14E-03 4.18E-04 7.38E-05 0.00E+00 2.22E-16 6.88E-06 1.17E-04 4.57E-04 6.86E-05 4.66E-05 2.22E-16 5.91E-04 1.72E-04 5.77E-04 1.02E-03 9.86E-03 1.19E-03 1.56E-04 2.23E-04 1.28E-02 7.68E-18 6.95E-04 0.00E+00 4.65E-04 4.31E-05 3.67E-05 2.80E-03 2.67E-04 1.01E-03 3.00E-03 1.59E-03 5.72E-03 5.62E-06 1.86E-03 1.71E-03 3.59E-04 2.02E-04 0.001697967239 0.000026827588 +C>G GCT G[C>G]T 2.23E-16 1.34E-04 1.47E-02 3.04E-03 6.72E-03 3.21E-04 4.20E-05 2.77E-04 1.28E-03 8.82E-04 4.86E-03 8.57E-03 3.54E-05 1.13E-04 1.86E-04 5.04E-04 2.70E-03 8.03E-05 4.51E-04 3.23E-03 7.87E-04 2.23E-16 1.23E-03 3.20E-04 3.02E-03 2.07E-04 4.55E-04 4.04E-18 3.38E-03 1.99E-03 3.05E-04 4.56E-03 2.22E-16 3.21E-03 3.99E-04 3.36E-03 2.28E-04 9.31E-04 2.69E-05 8.74E-03 1.05E-03 1.27E-03 9.17E-04 3.24E-02 6.98E-03 3.56E-03 2.77E-03 1.80E-02 1.85E-03 9.32E-04 6.00E-04 2.22E-03 6.53E-05 2.08E-04 1.43E-02 2.85E-03 1.02E-03 5.73E-04 4.94E-03 6.82E-05 1.75E-06 4.36E-04 1.08E-03 2.26E-03 6.43E-05 0.076057560709 0.003186103940 +C>G TCA T[C>G]A 2.23E-16 2.23E-16 1.33E-02 3.58E-03 7.81E-03 4.97E-05 2.23E-16 2.54E-04 1.94E-03 3.74E-03 1.47E-03 2.69E-03 5.55E-05 2.22E-16 1.56E-05 9.69E-04 3.17E-01 1.97E-05 2.14E-04 2.51E-03 3.75E-03 1.60E-04 2.14E-03 1.75E-03 1.29E-04 6.54E-04 3.56E-03 2.11E-04 3.75E-03 9.80E-03 1.31E-03 2.87E-03 1.15E-04 1.07E-04 1.27E-04 3.96E-04 4.71E-18 1.30E-02 6.18E-07 6.63E-03 3.98E-03 1.79E-03 2.66E-03 3.47E-02 1.25E-02 1.99E-02 5.59E-04 4.42E-06 6.73E-04 3.30E-03 2.80E-03 1.38E-04 1.37E-04 4.80E-05 9.32E-04 2.05E-03 1.98E-03 3.74E-03 4.69E-03 7.06E-03 1.13E-03 2.28E-03 2.13E-03 2.35E-06 5.29E-04 0.000000000000 0.000947995470 +C>G TCC T[C>G]C 2.03E-04 9.87E-05 2.03E-02 5.95E-03 7.60E-03 1.13E-04 5.09E-05 1.62E-03 4.61E-03 5.88E-04 1.34E-03 2.00E-03 2.23E-16 2.22E-16 2.24E-04 1.55E-03 6.35E-02 1.50E-04 6.12E-05 5.23E-03 7.23E-04 6.18E-05 4.64E-03 3.12E-03 2.82E-05 6.31E-04 1.52E-03 2.66E-04 5.58E-03 3.27E-03 7.45E-04 3.11E-03 1.36E-04 6.83E-03 9.86E-04 2.92E-03 1.10E-03 2.51E-03 1.40E-04 5.63E-03 2.41E-03 1.11E-03 2.18E-03 3.67E-02 1.41E-02 1.42E-02 1.87E-03 1.03E-03 9.40E-06 2.01E-03 2.40E-03 1.19E-03 3.50E-04 1.53E-04 4.93E-04 3.61E-03 1.44E-03 4.99E-03 5.17E-04 3.28E-03 2.94E-04 2.80E-03 1.80E-03 2.09E-03 3.48E-04 0.000113943392 0.001869404519 +C>G TCG T[C>G]G 6.94E-05 4.12E-05 5.20E-04 1.83E-03 1.71E-03 1.95E-06 6.35E-06 3.64E-04 8.75E-06 8.73E-04 7.82E-05 4.04E-04 2.23E-16 2.22E-16 2.22E-16 2.14E-04 1.38E-02 1.83E-05 5.84E-05 4.39E-04 3.80E-04 1.55E-05 8.99E-04 4.41E-04 1.24E-04 6.27E-05 3.81E-04 2.56E-18 1.35E-03 2.06E-03 9.41E-05 1.28E-05 2.46E-05 8.97E-04 1.06E-04 4.16E-04 9.97E-04 8.04E-05 2.22E-16 1.55E-04 3.02E-04 8.60E-04 1.10E-03 9.62E-03 1.74E-03 1.93E-03 2.07E-04 1.47E-03 7.68E-18 1.78E-04 1.00E-04 0.00E+00 2.82E-05 6.33E-05 1.03E-04 2.16E-03 5.81E-04 1.87E-03 1.23E-03 2.29E-04 8.39E-05 1.33E-03 6.30E-04 4.05E-04 6.59E-05 0.000000720571 0.000169996975 +C>G TCT T[C>G]T 1.56E-03 1.18E-03 2.35E-02 3.38E-03 1.25E-02 1.28E-04 2.81E-04 7.14E-04 1.23E-02 8.53E-05 2.49E-04 5.63E-03 5.45E-05 4.34E-05 1.85E-04 3.05E-03 3.69E-01 3.21E-04 1.74E-04 2.85E-02 2.83E-04 1.50E-03 3.18E-03 1.61E-03 1.12E-03 6.87E-04 3.88E-04 4.66E-04 4.07E-03 1.64E-02 2.21E-03 2.13E-03 1.43E-04 3.36E-04 1.09E-04 4.24E-03 6.92E-04 2.01E-02 2.15E-03 2.12E-02 7.59E-03 2.55E-03 3.95E-03 5.07E-02 2.37E-02 4.46E-02 3.81E-04 2.51E-04 2.59E-03 3.29E-03 4.90E-03 9.24E-04 1.48E-04 5.44E-04 4.21E-04 3.33E-03 2.42E-03 3.74E-03 3.11E-04 2.11E-03 4.11E-04 1.29E-02 1.81E-02 1.52E-03 7.61E-04 0.004953383455 0.006244142553 +C>T ACA A[C>T]A 2.50E-02 6.11E-05 1.42E-02 8.70E-03 3.26E-02 6.41E-02 1.22E-04 1.41E-03 1.33E-03 3.33E-03 6.81E-03 8.10E-03 1.04E-03 5.49E-04 2.58E-02 5.51E-03 7.18E-03 1.24E-02 5.05E-03 1.76E-03 1.22E-03 5.71E-04 9.20E-03 2.80E-02 4.93E-02 2.17E-03 1.76E-03 2.26E-02 1.18E-02 2.10E-02 2.66E-03 1.37E-02 7.77E-04 5.09E-03 1.06E-01 1.77E-02 8.64E-02 5.31E-03 3.52E-03 2.21E-03 5.96E-03 6.24E-03 3.45E-03 9.60E-03 1.97E-02 9.88E-03 2.24E-02 2.90E-05 8.99E-02 1.33E-03 1.52E-02 4.27E-03 2.87E-04 5.75E-04 3.52E-03 3.58E-02 2.69E-03 7.22E-03 1.48E-03 5.11E-03 7.40E-03 3.26E-02 8.05E-02 3.92E-03 2.76E-03 0.053885768706 0.001374780580 +C>T ACC A[C>T]C 6.32E-03 1.38E-03 1.24E-02 4.18E-03 1.79E-02 2.29E-02 1.77E-02 3.81E-02 7.68E-03 1.40E-03 2.82E-03 5.42E-03 8.34E-04 5.25E-03 1.47E-01 2.12E-03 2.22E-16 1.01E-02 6.91E-03 3.73E-03 1.71E-03 7.03E-05 4.65E-03 1.41E-02 1.30E-02 3.92E-03 2.20E-04 8.09E-02 1.12E-02 1.31E-02 2.54E-03 5.42E-03 3.38E-03 4.31E-03 9.04E-02 9.28E-03 1.23E-01 2.13E-03 3.71E-03 3.99E-03 3.28E-03 3.06E-03 2.15E-03 4.04E-03 1.21E-02 3.36E-03 3.98E-02 1.28E-04 1.69E-02 6.01E-04 8.90E-03 9.40E-04 4.38E-04 3.03E-04 1.80E-03 5.65E-03 2.10E-03 1.96E-03 5.29E-04 2.33E-04 9.82E-04 1.29E-02 6.76E-03 2.86E-03 1.34E-03 0.042106831614 0.001478441742 +C>T ACG A[C>T]G 3.65E-01 3.27E-05 2.57E-03 7.83E-04 6.18E-03 1.20E-01 2.23E-16 5.43E-04 9.27E-04 1.21E-03 3.23E-03 4.38E-03 5.57E-03 4.14E-04 7.58E-03 1.18E-04 3.03E-04 2.65E-02 7.45E-02 3.27E-03 3.95E-05 2.87E-04 1.22E-02 1.55E-03 1.33E-02 7.40E-03 1.36E-03 8.72E-03 5.14E-04 1.97E-02 5.33E-03 6.71E-03 7.05E-03 2.01E-02 1.44E-02 7.59E-03 3.66E-02 7.16E-03 1.18E-04 5.80E-04 7.07E-03 6.33E-03 5.18E-03 6.00E-03 2.67E-04 3.43E-03 4.40E-04 1.22E-03 1.43E-02 5.41E-03 4.60E-03 3.05E-03 1.21E-03 2.01E-03 1.39E-02 5.65E-03 4.08E-03 6.95E-03 3.43E-04 5.32E-03 1.52E-03 1.76E-02 8.63E-03 2.56E-03 4.21E-03 0.002540673114 0.000443775624 +C>T ACT A[C>T]T 9.58E-03 1.86E-03 1.21E-02 4.25E-03 2.20E-02 2.13E-02 7.42E-03 1.08E-02 7.48E-03 3.29E-02 1.25E-02 6.49E-03 2.99E-03 7.93E-03 1.09E-01 2.38E-03 3.18E-04 1.61E-02 1.78E-03 6.00E-03 7.37E-04 1.47E-04 7.97E-03 3.68E-02 1.30E-02 4.17E-05 6.16E-04 3.50E-02 9.15E-03 5.73E-03 2.79E-03 4.48E-03 5.06E-03 1.83E-03 2.93E-02 1.01E-02 1.52E-01 3.07E-03 3.87E-03 9.00E-04 4.31E-03 5.65E-03 2.44E-03 1.28E-02 1.69E-02 6.35E-03 3.52E-02 9.10E-04 3.03E-02 1.22E-03 6.80E-03 2.49E-03 2.35E-04 4.15E-04 6.92E-03 3.20E-03 1.76E-03 1.94E-03 4.99E-03 7.76E-04 2.84E-03 1.54E-02 7.31E-03 3.39E-03 2.98E-04 0.054345874146 0.004563583260 +C>T CCA C[C>T]A 2.00E-03 4.32E-03 1.61E-02 1.27E-02 1.94E-02 1.36E-02 5.00E-02 1.07E-01 2.71E-03 3.56E-02 2.67E-03 7.24E-03 3.68E-05 1.51E-04 4.07E-03 6.59E-03 1.93E-05 2.73E-03 1.08E-02 7.17E-03 8.21E-04 4.57E-04 1.17E-02 1.19E-01 1.06E-02 1.35E-03 1.21E-03 6.22E-02 5.38E-03 1.43E-02 1.69E-03 1.74E-02 2.92E-04 7.61E-03 1.10E-01 4.12E-02 1.69E-02 4.59E-03 4.75E-03 5.10E-03 6.75E-03 3.61E-03 4.24E-03 9.11E-03 1.96E-02 6.91E-03 1.87E-02 7.62E-06 3.57E-03 2.14E-03 2.84E-02 8.64E-04 1.82E-05 4.70E-04 3.84E-03 3.23E-03 3.27E-03 1.46E-02 3.37E-03 7.25E-03 2.98E-04 1.49E-02 8.09E-03 2.87E-03 1.52E-03 0.018028129532 0.001636999066 +C>T CCC C[C>T]C 2.70E-04 1.70E-04 2.02E-02 1.15E-02 1.90E-02 1.48E-02 5.53E-02 1.82E-01 5.97E-03 2.60E-03 4.02E-03 8.76E-03 2.23E-16 8.44E-05 1.26E-01 2.54E-04 1.35E-03 1.38E-03 1.11E-02 2.84E-03 1.72E-03 5.89E-05 6.76E-03 9.20E-02 1.30E-02 5.16E-03 3.19E-03 1.89E-01 8.85E-03 5.94E-03 2.83E-03 7.14E-03 2.10E-04 1.64E-03 1.03E-01 1.64E-01 2.84E-02 1.53E-03 5.14E-04 8.32E-02 6.68E-03 2.10E-03 4.73E-03 3.86E-03 1.73E-02 1.85E-03 4.81E-02 4.35E-18 2.86E-03 5.07E-05 1.33E-02 4.61E-03 3.01E-04 4.93E-04 4.25E-03 4.70E-03 1.82E-03 4.60E-03 2.26E-04 4.00E-03 5.31E-04 1.21E-02 9.92E-03 4.09E-04 1.88E-03 0.040621303139 0.000369373076 +C>T CCG C[C>T]G 1.96E-01 2.77E-03 2.24E-03 3.31E-03 1.75E-02 1.22E-01 6.71E-03 2.21E-02 8.94E-03 2.64E-03 1.49E-03 6.51E-03 2.23E-16 3.70E-03 9.20E-04 4.09E-05 1.99E-03 1.16E-02 2.48E-02 6.91E-04 1.90E-03 5.43E-04 1.68E-02 1.57E-02 1.65E-02 6.22E-03 4.26E-04 1.42E-02 6.35E-03 1.16E-02 3.34E-03 7.50E-03 2.55E-03 1.53E-02 1.68E-02 8.20E-03 1.12E-02 5.88E-03 9.45E-03 2.67E-03 5.33E-03 3.27E-03 3.50E-03 7.57E-03 2.36E-03 1.01E-02 1.92E-03 9.72E-05 1.55E-02 2.20E-03 8.30E-03 1.52E-03 1.87E-05 1.38E-03 1.08E-03 2.07E-02 2.38E-03 1.37E-02 2.83E-02 6.59E-05 7.95E-03 6.40E-03 7.99E-03 1.10E-03 4.06E-03 0.000000000000 0.000024057242 +C>T CCT C[C>T]T 1.96E-04 1.45E-03 2.30E-02 1.60E-02 2.31E-02 1.38E-02 5.66E-02 1.26E-01 2.06E-02 1.38E-04 1.45E-02 1.11E-02 1.03E-04 5.95E-04 6.51E-02 3.38E-03 1.45E-03 1.36E-03 1.56E-02 1.93E-02 1.74E-03 1.36E-04 6.65E-03 2.58E-01 1.17E-02 3.25E-04 1.60E-03 1.56E-01 4.29E-03 1.36E-02 1.65E-03 7.15E-03 3.32E-03 6.73E-04 4.62E-02 1.45E-01 4.28E-02 2.70E-03 3.53E-05 4.70E-02 5.75E-03 6.06E-03 4.10E-03 6.99E-03 2.16E-02 7.73E-03 3.29E-02 7.44E-04 5.04E-03 2.73E-03 6.40E-03 3.00E-03 4.79E-04 5.19E-04 1.19E-02 4.06E-03 2.57E-03 1.60E-02 3.71E-03 7.19E-04 5.08E-04 3.20E-02 2.77E-02 2.42E-03 2.51E-03 0.042237294613 0.002350306147 +C>T GCA G[C>T]A 4.44E-03 2.23E-16 1.64E-02 4.09E-03 1.94E-02 9.36E-02 8.49E-05 8.55E-04 1.57E-04 3.65E-04 2.76E-04 6.98E-03 4.22E-05 3.63E-04 1.97E-02 4.48E-03 7.18E-03 1.71E-02 7.37E-02 6.50E-03 1.64E-03 6.11E-05 9.68E-03 6.10E-02 4.22E-02 9.32E-03 2.38E-03 5.37E-02 2.99E-02 1.00E-02 2.75E-03 1.42E-02 3.25E-03 1.04E-02 4.97E-02 6.80E-03 2.26E-02 5.35E-03 2.33E-04 7.29E-03 3.72E-03 2.55E-03 2.37E-03 8.03E-03 1.43E-02 6.01E-03 3.36E-02 7.66E-04 9.55E-02 1.00E-03 1.26E-02 1.06E-03 3.45E-04 1.84E-04 2.42E-03 4.47E-03 1.78E-03 9.18E-03 2.22E-04 6.50E-03 9.49E-06 5.14E-03 6.78E-03 2.44E-03 1.24E-03 0.089177561445 0.000887033367 +C>T GCC G[C>T]C 9.28E-05 1.29E-07 1.34E-02 4.46E-03 2.16E-02 1.11E-01 1.17E-02 2.63E-02 9.51E-06 1.81E-04 2.45E-04 6.53E-03 1.25E-02 1.51E-02 1.15E-01 1.82E-03 9.21E-04 8.16E-03 1.29E-01 5.29E-03 2.22E-16 1.57E-04 8.17E-03 3.97E-02 5.32E-02 1.96E-02 1.87E-03 1.54E-01 4.37E-02 6.95E-03 5.45E-03 2.01E-02 1.88E-04 7.96E-03 6.10E-02 1.14E-02 3.79E-02 5.14E-03 2.22E-16 1.78E-02 3.40E-03 2.31E-03 2.96E-03 4.50E-03 1.16E-02 8.64E-03 1.52E-01 4.10E-18 8.14E-02 9.33E-04 4.50E-03 1.71E-03 7.39E-06 1.18E-04 1.58E-03 3.09E-03 1.22E-03 1.19E-02 1.31E-02 1.51E-03 5.06E-04 6.93E-03 3.15E-03 2.35E-03 1.44E-03 0.111629551116 0.000484366313 +C>T GCG G[C>T]G 2.18E-01 2.23E-16 5.28E-04 4.82E-04 1.23E-02 1.78E-01 5.52E-06 1.76E-04 3.43E-05 1.57E-04 1.91E-03 4.76E-03 1.49E-02 1.26E-02 1.78E-03 7.46E-05 1.78E-04 1.92E-05 2.77E-01 1.17E-03 1.61E-03 8.55E-04 1.48E-02 3.21E-03 2.05E-02 4.34E-05 2.22E-16 1.23E-02 2.54E-02 1.05E-02 6.68E-03 9.37E-03 2.15E-04 1.83E-02 5.24E-03 1.97E-03 1.04E-02 5.84E-03 1.67E-02 2.53E-03 5.70E-03 4.32E-03 4.48E-03 5.48E-03 3.93E-18 1.71E-02 4.55E-03 9.66E-06 4.96E-02 1.51E-03 1.50E-03 1.72E-03 3.03E-04 1.04E-03 5.50E-03 4.28E-03 2.83E-03 5.99E-03 1.91E-02 1.19E-02 2.06E-03 8.44E-03 7.36E-03 3.24E-18 3.36E-03 0.009223925314 0.000116423626 +C>T GCT G[C>T]T 3.84E-05 5.04E-05 1.13E-02 3.81E-03 1.86E-02 7.44E-02 1.61E-02 5.39E-03 7.58E-04 4.21E-02 4.61E-03 1.07E-02 1.35E-02 3.19E-02 6.96E-02 2.67E-03 1.27E-03 1.05E-02 7.72E-02 6.72E-03 6.60E-05 2.23E-16 6.69E-03 1.09E-01 3.31E-02 8.05E-03 1.76E-03 1.07E-01 2.03E-02 9.82E-03 4.98E-03 7.59E-03 1.02E-04 5.12E-03 1.77E-02 5.70E-03 5.32E-02 3.93E-03 5.17E-04 6.03E-03 3.63E-03 2.32E-03 3.20E-03 8.61E-03 1.27E-02 8.41E-03 8.65E-02 1.86E-03 6.66E-02 1.99E-03 4.00E-03 4.04E-03 1.10E-04 3.08E-04 1.63E-02 5.95E-03 1.02E-03 3.10E-03 2.48E-04 5.29E-03 8.30E-04 6.18E-03 5.03E-03 2.96E-03 8.94E-04 0.180440456121 0.004167105016 +C>T TCA T[C>T]A 1.11E-03 5.36E-01 5.76E-03 3.74E-03 2.03E-02 1.20E-02 2.38E-01 6.61E-03 1.73E-02 2.07E-04 5.04E-03 4.27E-03 3.66E-04 2.73E-03 9.78E-03 5.52E-03 6.93E-03 3.54E-03 2.65E-02 6.36E-03 5.32E-04 1.08E-04 1.14E-02 4.39E-02 8.07E-03 3.60E-03 1.59E-03 1.53E-02 2.40E-03 1.11E-02 3.29E-03 1.88E-02 4.84E-03 6.39E-03 9.80E-02 7.48E-03 2.48E-02 1.47E-02 1.86E-03 2.96E-03 1.07E-02 4.02E-03 6.45E-03 3.88E-03 3.00E-02 1.17E-02 4.82E-03 3.72E-05 1.40E-03 2.40E-03 1.85E-02 7.24E-03 2.14E-04 1.87E-04 1.94E-02 1.70E-03 1.47E-03 5.73E-03 7.45E-18 5.82E-11 2.00E-04 8.14E-03 4.29E-03 1.61E-04 4.07E-05 0.000070752091 0.003823610731 +C>T TCC T[C>T]C 3.73E-05 9.73E-02 1.33E-02 6.99E-03 2.30E-02 1.05E-02 3.31E-01 2.11E-01 1.37E-02 5.65E-03 2.52E-04 7.33E-03 2.76E-03 4.85E-02 1.58E-01 2.64E-03 4.48E-03 1.37E-04 9.56E-03 3.68E-03 9.06E-05 6.04E-04 1.14E-02 2.50E-02 9.19E-03 8.07E-05 1.32E-03 4.36E-02 1.22E-02 6.45E-03 2.53E-03 7.99E-03 4.13E-03 3.61E-18 1.34E-01 2.46E-02 3.87E-02 3.17E-03 2.89E-04 1.26E-02 6.86E-03 2.50E-03 7.23E-03 5.28E-03 2.31E-02 6.47E-03 3.27E-02 5.06E-18 2.25E-03 2.02E-03 1.26E-02 3.71E-02 3.17E-04 5.82E-04 1.04E-01 1.77E-03 1.53E-03 5.77E-03 6.61E-04 4.11E-03 1.84E-04 1.73E-02 1.53E-02 2.80E-04 9.58E-04 0.026909334242 0.002998120759 +C>T TCG T[C>T]G 1.10E-01 4.42E-02 9.89E-04 2.81E-04 1.59E-02 5.20E-02 7.41E-02 5.74E-02 4.64E-05 1.75E-03 4.17E-05 3.26E-03 2.79E-03 4.37E-01 2.94E-07 8.85E-05 1.19E-03 5.32E-03 2.12E-02 3.02E-03 1.77E-04 6.24E-05 1.18E-02 4.32E-03 2.64E-03 3.17E-04 3.77E-05 2.87E-03 2.69E-03 1.41E-02 2.63E-03 4.61E-03 1.74E-03 1.44E-02 1.47E-02 8.41E-03 9.85E-03 3.85E-03 3.00E-04 7.65E-04 3.89E-03 3.43E-03 3.47E-03 4.86E-03 2.12E-03 4.92E-03 3.64E-04 3.07E-18 7.68E-18 1.75E-03 3.70E-03 1.94E-03 4.02E-04 9.34E-04 3.97E-03 6.49E-03 2.19E-03 1.02E-02 1.19E-13 4.81E-03 1.54E-04 4.60E-03 3.34E-03 4.54E-18 1.73E-03 0.000006923779 0.000157958968 +C>T TCT T[C>T]T 2.23E-16 3.00E-01 8.17E-03 7.22E-03 2.10E-02 6.99E-03 1.07E-01 1.02E-01 2.32E-03 5.00E-02 5.27E-03 5.46E-03 2.28E-02 1.28E-01 1.19E-01 6.12E-03 1.42E-03 3.59E-04 1.74E-03 2.21E-02 3.48E-04 8.95E-04 3.75E-03 6.29E-02 5.00E-05 7.31E-05 2.22E-16 2.63E-02 4.71E-03 1.24E-02 2.13E-03 1.19E-02 1.99E-03 4.28E-03 5.25E-02 1.95E-02 6.70E-02 9.04E-03 8.08E-04 8.04E-03 8.33E-03 5.84E-03 6.58E-03 4.23E-03 2.24E-02 1.15E-02 1.51E-02 8.36E-04 3.02E-03 2.95E-03 4.40E-03 8.09E-02 5.85E-06 3.12E-04 8.18E-02 4.24E-02 1.65E-03 7.71E-03 2.36E-04 3.14E-02 8.20E-05 3.72E-02 1.79E-01 2.09E-03 3.91E-03 0.016839668838 0.038650889984 +T>A ATA A[T>A]A 8.00E-04 9.59E-05 5.49E-03 9.42E-03 7.38E-03 9.82E-05 1.94E-03 2.49E-03 1.24E-02 8.89E-05 1.95E-02 1.27E-02 5.07E-05 1.82E-03 4.17E-04 5.17E-03 2.22E-16 6.13E-04 2.04E-03 2.31E-02 1.01E-03 6.26E-05 2.49E-03 7.86E-04 5.11E-04 3.46E-03 6.39E-02 8.28E-18 1.58E-03 2.04E-02 1.52E-03 1.43E-01 1.72E-04 6.19E-04 3.63E-04 7.86E-03 7.13E-04 8.68E-04 1.03E-01 4.89E-03 2.44E-03 2.25E-03 1.99E-03 5.31E-03 6.10E-03 7.46E-03 1.33E-02 1.53E-02 4.78E-03 5.25E-04 2.70E-03 1.38E-01 6.60E-04 1.29E-04 5.36E-03 1.13E-01 1.77E-03 5.89E-03 9.56E-04 4.26E-03 5.05E-06 3.28E-03 2.45E-02 2.00E-03 3.97E-03 0.001562338887 0.111858717410 +T>A ATC A[T>A]C 2.23E-03 8.78E-04 7.21E-03 3.53E-03 6.93E-03 5.46E-04 6.70E-04 4.67E-04 3.42E-03 1.08E-03 2.13E-02 2.82E-03 1.94E-04 3.37E-04 4.41E-04 2.71E-03 6.52E-05 3.72E-04 8.41E-04 7.74E-03 9.97E-04 2.89E-04 8.78E-04 2.55E-04 5.19E-03 5.65E-03 7.01E-03 5.56E-18 2.25E-03 8.89E-03 3.52E-03 1.46E-03 4.78E-04 2.00E-03 3.93E-04 6.07E-03 8.87E-04 1.14E-03 4.44E-02 7.36E-03 1.43E-03 1.66E-03 1.94E-03 2.88E-03 4.44E-03 4.30E-03 4.01E-03 3.78E-03 2.60E-03 4.97E-04 1.80E-03 7.16E-03 2.66E-04 7.78E-05 3.94E-03 1.35E-03 1.18E-03 2.59E-03 3.19E-03 6.18E-04 4.29E-03 6.43E-03 1.46E-03 2.50E-03 2.23E-04 0.000397461148 0.013051252824 +T>A ATG A[T>A]G 1.14E-03 2.55E-05 9.64E-03 1.24E-02 9.12E-03 2.22E-16 5.87E-04 1.56E-03 2.11E-04 3.70E-03 2.28E-02 2.76E-03 2.23E-16 2.34E-05 3.93E-05 3.12E-03 5.90E-04 3.54E-04 5.40E-04 8.81E-03 2.00E-04 6.57E-05 2.60E-03 9.52E-04 3.03E-04 2.48E-04 6.06E-02 3.54E-04 2.00E-03 6.24E-03 6.25E-04 1.23E-03 1.52E-04 2.48E-03 6.38E-04 5.03E-03 7.12E-04 6.96E-04 3.46E-02 1.33E-03 2.53E-03 2.49E-03 1.08E-03 6.94E-03 6.93E-03 3.03E-03 5.01E-03 1.43E-03 1.08E-06 2.13E-03 5.00E-04 7.45E-03 4.65E-04 2.41E-04 5.73E-04 3.68E-02 1.19E-03 2.87E-03 4.23E-03 8.10E-03 5.13E-04 5.80E-03 4.69E-03 2.19E-03 3.52E-04 0.000070829550 0.021107255813 +T>A ATT A[T>A]T 1.83E-04 2.23E-16 6.11E-03 4.21E-03 6.20E-03 1.66E-03 3.71E-03 8.29E-03 5.07E-02 4.11E-02 2.50E-02 1.89E-02 6.66E-03 2.85E-03 3.40E-06 2.82E-03 6.06E-04 1.85E-03 9.54E-03 1.10E-02 1.46E-03 6.33E-04 7.84E-03 6.54E-04 2.56E-02 1.60E-03 2.51E-03 1.61E-04 1.80E-03 1.49E-02 3.07E-03 2.54E-03 1.70E-03 1.96E-03 4.90E-04 4.16E-03 8.44E-04 5.07E-03 3.16E-01 7.37E-03 3.07E-03 2.77E-03 2.72E-03 6.12E-03 1.07E-02 6.96E-02 6.85E-03 4.28E-03 3.08E-02 6.05E-04 2.00E-03 6.76E-02 6.75E-04 3.54E-04 2.41E-03 2.95E-02 1.19E-03 4.63E-03 3.01E-04 3.92E-03 2.90E-02 6.31E-03 8.77E-03 2.80E-03 7.28E-04 0.010652827921 0.070288409275 +T>A CTA C[T>A]A 4.30E-05 2.43E-04 7.94E-03 1.44E-02 3.54E-03 6.66E-05 1.77E-04 1.12E-03 3.47E-03 1.61E-03 1.90E-02 4.79E-03 2.23E-16 7.09E-05 1.84E-04 5.46E-04 2.09E-04 1.55E-04 3.48E-04 3.21E-03 4.34E-04 9.36E-05 5.42E-04 9.60E-05 1.44E-04 6.19E-06 1.28E-01 4.62E-04 1.32E-03 2.63E-02 9.44E-04 3.31E-01 1.40E-04 1.95E-03 2.14E-04 2.06E-02 3.25E-04 7.46E-04 2.37E-02 5.26E-02 1.26E-03 1.57E-03 8.97E-04 4.94E-03 1.09E-03 3.62E-03 1.26E-02 1.36E-03 1.24E-05 6.97E-04 4.20E-03 1.40E-02 8.62E-05 7.41E-05 1.93E-04 6.11E-03 1.22E-03 3.69E-03 7.45E-18 7.39E-05 1.19E-03 6.39E-03 2.48E-03 7.03E-05 6.64E-05 0.000136550096 0.009896320186 +T>A CTC C[T>A]C 3.93E-04 2.44E-04 1.78E-02 1.22E-02 5.19E-03 5.51E-04 2.61E-04 9.58E-04 1.34E-02 8.13E-05 2.92E-02 3.13E-03 2.23E-16 1.06E-04 2.12E-04 5.60E-03 3.42E-04 2.95E-03 2.44E-04 5.70E-03 4.05E-02 2.24E-03 3.06E-03 4.03E-04 6.48E-03 6.88E-04 5.51E-02 4.47E-18 1.87E-03 1.58E-02 1.45E-03 2.81E-03 1.35E-03 1.41E-03 7.77E-04 2.11E-02 6.50E-04 9.92E-04 4.09E-04 3.30E-02 1.46E-03 1.16E-03 2.02E-03 6.44E-03 7.62E-03 3.19E-03 1.72E-03 1.21E-05 3.25E-03 1.04E-03 3.30E-03 5.71E-04 1.02E-04 5.14E-05 5.35E-04 1.49E-03 2.31E-04 4.50E-03 7.32E-04 1.10E-06 9.74E-04 6.59E-03 2.23E-02 1.64E-03 5.14E-04 0.000000000000 0.001136017362 +T>A CTG C[T>A]G 3.24E-04 1.49E-04 1.32E-02 3.25E-02 5.01E-03 1.15E-04 1.12E-04 8.83E-04 9.61E-04 1.20E-03 2.76E-02 5.31E-03 2.23E-16 2.22E-16 3.05E-04 1.41E-03 2.26E-04 3.17E-04 8.20E-05 1.03E-03 1.24E-02 7.17E-04 3.21E-03 2.94E-04 1.23E-04 1.25E-04 1.68E-01 1.32E-04 5.03E-03 6.29E-02 1.14E-03 4.40E-03 8.06E-04 1.98E-03 5.87E-04 1.87E-02 1.41E-03 4.79E-04 1.17E-03 5.82E-02 2.14E-03 1.60E-03 1.78E-03 6.80E-03 3.46E-03 3.12E-03 1.49E-02 2.96E-04 5.82E-04 3.41E-03 4.30E-03 5.82E-05 3.10E-04 2.32E-04 5.16E-04 6.52E-03 1.23E-03 3.30E-03 1.92E-03 1.60E-02 1.59E-03 1.29E-03 8.58E-04 1.39E-04 3.81E-07 0.000125175761 0.000178582568 +T>A CTT C[T>A]T 2.60E-04 2.23E-16 1.27E-02 1.18E-02 4.30E-03 1.79E-04 3.71E-04 1.12E-04 4.87E-02 1.15E-03 4.18E-02 4.44E-03 3.76E-04 2.34E-04 1.62E-04 1.50E-03 5.23E-04 1.38E-03 1.05E-03 6.53E-03 7.23E-02 7.79E-03 2.26E-03 2.18E-04 1.02E-04 2.22E-16 6.03E-02 3.75E-04 4.80E-03 3.66E-02 6.42E-04 5.43E-03 1.03E-03 1.98E-03 6.12E-04 3.10E-02 6.63E-04 1.12E-03 2.68E-04 6.64E-02 1.96E-03 2.06E-03 2.36E-03 8.27E-03 9.28E-03 9.01E-03 7.57E-03 2.03E-04 1.38E-05 1.34E-03 3.60E-03 7.60E-05 3.62E-04 1.06E-04 2.09E-04 3.62E-03 8.56E-04 8.61E-03 6.66E-05 5.23E-03 6.09E-06 1.07E-02 1.30E-03 3.71E-03 1.32E-04 0.000000000000 0.010551155388 +T>A GTA G[T>A]A 8.12E-05 2.23E-16 7.06E-03 9.22E-03 3.67E-03 5.10E-05 4.01E-04 5.26E-04 1.73E-03 2.37E-05 1.28E-02 2.65E-03 3.31E-06 2.22E-16 1.54E-06 8.26E-04 6.70E-06 5.77E-05 5.11E-04 9.40E-04 6.46E-05 9.73E-05 1.60E-03 1.89E-04 5.56E-05 1.17E-03 5.37E-02 6.26E-18 1.57E-03 3.62E-02 7.83E-04 1.10E-01 1.16E-04 3.43E-03 3.29E-04 1.90E-03 8.79E-03 8.10E-04 1.90E-02 7.17E-04 8.80E-04 1.15E-03 8.93E-04 4.96E-03 2.65E-03 2.33E-03 1.20E-02 6.18E-03 1.16E-03 3.00E-04 6.10E-03 1.60E-02 1.30E-04 5.04E-05 7.32E-04 2.04E-02 5.24E-04 4.45E-03 2.33E-03 2.43E-03 4.20E-04 3.33E-03 2.07E-03 2.55E-04 1.09E-04 0.001098638590 0.017239232975 +T>A GTC G[T>A]C 1.29E-04 1.31E-04 7.48E-03 3.60E-03 2.91E-03 4.89E-04 2.24E-04 2.56E-04 2.27E-03 1.12E-04 1.35E-02 2.12E-03 2.23E-16 1.23E-04 3.75E-04 1.81E-03 1.30E-04 2.73E-03 5.89E-04 6.08E-04 3.40E-03 3.47E-04 1.95E-03 7.78E-05 2.56E-03 3.26E-03 1.02E-02 1.40E-04 2.35E-03 5.85E-03 1.15E-03 2.35E-05 1.18E-04 7.89E-04 1.82E-04 2.91E-03 8.22E-03 3.62E-04 2.42E-03 5.56E-03 6.31E-04 7.74E-04 1.12E-03 3.52E-03 3.43E-03 2.29E-03 1.84E-03 1.33E-03 2.36E-03 6.38E-04 1.00E-03 2.28E-04 1.24E-04 9.10E-05 1.05E-03 3.85E-03 3.99E-04 2.70E-03 8.99E-03 1.85E-04 2.37E-03 5.97E-04 6.26E-04 1.98E-03 1.10E-04 0.000065576983 0.001005109264 +T>A GTG G[T>A]G 2.46E-04 6.38E-05 1.16E-02 1.31E-02 4.11E-03 1.95E-04 2.90E-04 6.56E-04 2.22E-16 1.35E-03 1.56E-02 7.88E-04 7.30E-05 2.22E-16 1.19E-04 2.51E-03 4.70E-05 1.20E-04 1.87E-04 5.55E-03 6.95E-04 2.41E-04 1.83E-03 4.86E-04 2.13E-03 7.42E-04 3.75E-02 4.68E-18 2.49E-03 3.82E-02 6.08E-04 1.57E-03 7.17E-05 3.66E-03 9.86E-05 5.77E-03 1.31E-02 8.27E-04 6.53E-03 1.12E-03 1.17E-03 1.08E-03 1.21E-03 6.67E-03 4.41E-03 1.43E-03 7.77E-03 4.50E-03 2.21E-03 1.03E-03 2.40E-03 1.31E-05 1.43E-04 1.10E-04 1.99E-04 4.29E-03 1.29E-03 3.96E-03 2.64E-03 1.25E-02 4.36E-04 2.46E-03 2.04E-02 5.05E-04 3.60E-04 0.000337380913 0.003520166086 +T>A GTT G[T>A]T 2.58E-04 6.28E-05 1.23E-02 5.52E-03 3.22E-03 2.48E-04 3.06E-04 5.59E-05 2.03E-02 8.76E-03 2.81E-02 2.56E-03 4.26E-04 1.08E-04 1.64E-04 9.15E-04 3.58E-04 8.57E-04 8.40E-04 9.66E-04 4.80E-03 1.58E-03 3.46E-03 2.83E-04 4.30E-03 9.37E-04 9.32E-03 5.78E-18 1.31E-03 2.02E-02 8.34E-04 0.00E+00 3.24E-04 1.07E-03 1.91E-04 7.89E-04 6.16E-03 1.76E-03 7.48E-03 2.86E-03 1.12E-03 1.68E-03 1.84E-03 4.09E-03 5.77E-03 4.52E-03 3.25E-03 1.31E-03 3.18E-03 5.10E-04 1.20E-03 3.28E-06 2.31E-04 1.31E-04 7.86E-04 1.46E-04 8.11E-04 3.11E-03 1.85E-03 5.12E-03 5.37E-03 7.93E-03 2.77E-03 1.51E-03 6.37E-04 0.000135756563 0.011658501206 +T>A TTA T[T>A]A 6.72E-03 4.22E-04 6.51E-03 8.88E-03 6.31E-03 4.54E-04 3.56E-04 3.24E-03 1.54E-02 1.67E-02 1.15E-02 2.60E-02 2.04E-03 3.06E-03 1.86E-04 3.75E-03 2.96E-04 2.00E-04 1.09E-03 1.23E-02 1.19E-04 1.19E-03 1.08E-02 4.94E-04 1.20E-02 2.57E-04 7.18E-02 7.77E-18 4.12E-03 2.18E-02 1.13E-03 5.28E-02 1.88E-04 7.64E-04 2.82E-04 6.70E-03 5.12E-04 4.10E-03 2.72E-01 4.30E-03 2.46E-03 2.45E-03 2.44E-03 6.69E-03 7.13E-03 8.06E-02 8.50E-03 7.63E-05 6.96E-03 4.07E-04 4.50E-03 1.56E-01 2.35E-05 4.20E-04 1.69E-03 2.01E-02 1.05E-03 3.10E-03 1.55E-03 3.61E-03 9.42E-03 3.02E-03 1.19E-02 2.09E-03 1.13E-03 0.006569907486 0.060179901809 +T>A TTC T[T>A]C 2.23E-16 1.92E-04 1.05E-02 4.31E-03 4.14E-03 1.14E-04 3.89E-04 2.24E-03 3.42E-02 1.23E-03 1.95E-02 1.85E-03 3.60E-04 6.65E-04 2.02E-04 6.45E-03 2.32E-04 1.73E-03 1.57E-04 4.67E-03 5.70E-03 2.42E-04 2.73E-03 4.75E-04 3.18E-04 7.95E-04 2.36E-02 5.27E-18 3.27E-03 3.41E-03 1.26E-03 4.71E-05 1.25E-03 1.93E-03 2.41E-04 3.75E-03 2.45E-03 2.17E-04 2.22E-16 5.30E-03 1.02E-03 1.13E-03 9.28E-04 3.69E-03 1.03E-02 1.43E-02 2.26E-03 9.38E-04 2.07E-05 2.62E-04 4.30E-03 1.23E-05 7.64E-06 5.70E-05 6.64E-04 2.58E-03 4.69E-04 3.56E-03 1.79E-04 6.95E-05 8.05E-04 9.23E-03 8.98E-04 1.86E-03 2.23E-16 0.000864507132 0.007794895232 +T>A TTG T[T>A]G 2.80E-05 5.01E-05 6.71E-03 9.54E-03 4.79E-03 2.95E-05 2.23E-16 1.70E-03 1.22E-02 5.60E-03 1.29E-02 1.67E-02 6.93E-04 7.06E-05 2.01E-04 2.77E-03 1.88E-04 3.57E-04 1.49E-04 5.18E-03 1.83E-03 2.23E-16 1.79E-03 3.73E-04 1.76E-04 9.85E-05 7.32E-02 1.85E-04 1.99E-03 1.02E-02 2.78E-04 0.00E+00 3.21E-04 9.24E-04 1.90E-04 3.27E-03 1.76E-03 6.60E-04 7.77E-03 1.38E-03 8.72E-04 1.28E-03 8.04E-04 5.46E-03 5.02E-03 9.29E-03 5.33E-03 5.14E-05 5.02E-06 6.54E-04 5.00E-04 4.52E-04 8.32E-06 7.53E-05 7.54E-05 4.03E-03 7.78E-04 1.60E-03 3.29E-04 9.48E-03 6.36E-03 4.40E-03 8.29E-04 4.53E-04 4.24E-05 0.000784032307 0.006733400083 +T>A TTT T[T>A]T 2.25E-03 2.05E-04 1.30E-02 5.62E-03 8.75E-03 4.26E-04 7.98E-04 2.22E-16 2.79E-01 2.73E-02 3.79E-02 1.70E-02 5.29E-03 1.52E-03 6.74E-04 5.25E-03 6.20E-05 1.82E-03 4.75E-04 7.16E-03 1.98E-03 1.31E-03 7.10E-03 6.73E-04 6.71E-03 7.64E-05 3.01E-02 7.32E-18 2.19E-03 1.45E-02 1.31E-03 1.93E-03 5.72E-03 1.20E-03 7.01E-04 8.88E-03 7.11E-04 2.72E-03 4.60E-02 5.41E-03 2.70E-03 1.95E-03 2.50E-03 1.07E-02 2.10E-02 5.35E-02 3.52E-03 8.77E-18 1.39E-02 1.39E-03 3.40E-03 4.35E-03 4.26E-04 3.31E-04 2.95E-03 6.38E-03 1.34E-03 5.08E-03 7.45E-18 2.10E-03 7.44E-04 2.89E-02 1.46E-02 2.99E-03 5.30E-04 0.007059955557 0.062798279518 +T>C ATA A[T>C]A 1.09E-03 6.17E-05 1.65E-02 7.95E-03 4.62E-02 2.21E-03 4.90E-04 1.02E-03 2.88E-04 4.36E-03 9.77E-03 2.03E-02 7.45E-04 9.35E-03 1.14E-03 7.36E-02 1.91E-03 1.26E-02 3.89E-03 2.42E-01 9.65E-05 9.73E-05 2.02E-03 2.59E-03 1.07E-02 1.67E-02 2.50E-02 8.86E-04 6.40E-03 2.07E-02 8.48E-02 5.05E-03 5.49E-04 1.96E-03 6.11E-04 2.04E-02 9.36E-04 1.25E-02 4.62E-03 2.04E-03 5.25E-03 7.33E-02 2.79E-03 1.12E-02 1.87E-02 1.44E-02 1.16E-02 8.88E-06 1.93E-02 1.37E-03 1.85E-02 2.83E-03 1.10E-03 6.13E-04 2.63E-03 2.59E-03 3.75E-03 1.13E-02 2.92E-02 4.35E-03 1.25E-02 2.66E-02 8.05E-02 9.95E-03 1.29E-03 0.000000000000 0.029567020575 +T>C ATC A[T>C]C 3.04E-03 2.15E-05 7.76E-03 7.15E-04 1.34E-02 1.13E-03 2.27E-04 4.56E-04 5.33E-04 3.93E-03 5.01E-03 1.05E-02 3.62E-03 5.10E-04 9.38E-04 4.03E-02 1.42E-04 6.30E-03 1.96E-03 1.29E-02 1.27E-02 2.52E-04 2.09E-03 5.94E-04 4.55E-03 1.00E-02 8.99E-04 1.78E-04 2.18E-03 9.50E-03 2.61E-02 1.85E-03 4.41E-04 2.29E-03 4.58E-04 7.40E-03 7.01E-04 3.75E-03 1.23E-03 8.21E-04 1.69E-03 3.84E-02 1.64E-03 5.64E-03 7.34E-03 5.79E-03 3.51E-03 3.13E-02 3.24E-03 4.18E-04 4.78E-02 5.67E-03 1.89E-04 8.14E-05 9.28E-03 1.93E-02 1.88E-03 3.70E-03 7.75E-03 3.36E-06 6.16E-03 9.66E-03 4.93E-03 2.61E-03 2.77E-04 0.000323133451 0.020410486307 +T>C ATG A[T>C]G 1.06E-04 1.32E-05 1.23E-02 5.00E-03 3.82E-02 4.24E-03 1.87E-04 1.50E-03 1.07E-03 9.19E-03 6.98E-03 1.43E-02 2.14E-03 5.31E-04 3.20E-04 7.05E-02 4.28E-04 1.24E-02 2.40E-04 6.39E-02 3.76E-04 2.23E-16 2.08E-03 2.31E-03 1.86E-02 3.88E-03 7.75E-03 4.70E-04 1.76E-03 1.99E-02 7.85E-02 5.69E-03 4.05E-04 2.75E-03 2.77E-04 8.12E-03 1.09E-03 7.34E-02 1.95E-05 9.20E-04 3.84E-03 1.68E-02 2.17E-03 9.64E-03 1.55E-02 8.04E-03 8.56E-03 5.86E-04 2.72E-02 2.07E-03 3.29E-02 2.09E-03 2.85E-04 2.00E-04 1.13E-03 3.95E-03 2.62E-03 8.25E-03 2.02E-01 4.02E-03 9.55E-03 1.03E-02 6.75E-03 3.52E-03 3.52E-06 0.000011504801 0.005070940432 +T>C ATT A[T>C]T 5.74E-03 1.55E-04 1.73E-02 1.56E-03 3.83E-02 5.02E-04 6.15E-04 2.15E-03 2.65E-03 5.10E-02 1.49E-02 2.90E-02 3.36E-03 1.50E-04 1.19E-03 6.38E-02 9.59E-04 5.97E-03 9.29E-04 1.36E-01 7.79E-03 5.44E-04 4.24E-03 1.74E-03 1.03E-04 2.56E-02 7.55E-04 2.61E-04 2.44E-03 1.45E-02 3.72E-02 2.59E-03 5.95E-04 1.15E-03 5.45E-04 8.47E-03 6.10E-04 9.21E-03 2.34E-03 2.03E-03 5.12E-03 4.80E-02 3.49E-03 1.36E-02 1.94E-02 1.77E-02 2.70E-03 8.80E-03 2.67E-04 1.46E-03 3.06E-02 1.30E-03 1.11E-03 4.82E-04 4.92E-03 1.87E-03 4.92E-03 7.18E-03 7.83E-03 1.37E-02 1.24E-02 1.79E-02 8.16E-03 1.08E-02 3.63E-05 0.009382160052 0.059234079950 +T>C CTA C[T>C]A 2.23E-16 3.02E-04 8.83E-03 5.18E-03 1.33E-02 1.66E-03 4.51E-04 1.53E-03 7.57E-03 1.02E-02 2.39E-03 1.37E-02 1.22E-04 1.32E-03 3.28E-04 4.54E-02 4.74E-05 3.16E-03 7.50E-04 1.07E-02 1.11E-02 6.47E-04 3.86E-04 4.52E-04 1.17E-02 1.15E-02 6.74E-03 6.86E-18 2.27E-03 9.03E-03 5.20E-02 4.90E-03 1.32E-03 1.18E-03 1.27E-03 8.15E-03 5.93E-04 1.51E-02 5.94E-04 1.33E-03 1.50E-03 5.00E-02 1.95E-03 7.34E-03 1.09E-02 1.03E-02 3.54E-03 2.72E-03 1.46E-02 1.11E-03 2.23E-02 1.91E-03 1.45E-04 1.21E-04 8.39E-04 4.18E-03 2.39E-03 1.01E-02 1.14E-02 4.18E-03 3.37E-03 1.20E-02 3.92E-03 2.20E-03 8.79E-04 0.002269665991 0.007184033893 +T>C CTC C[T>C]C 2.50E-03 2.85E-05 1.45E-02 2.36E-03 1.04E-02 1.03E-03 2.59E-04 8.40E-04 3.58E-03 8.89E-05 7.00E-03 1.53E-02 4.12E-05 1.24E-04 7.13E-04 4.97E-02 1.22E-04 5.34E-03 2.15E-03 3.17E-03 1.73E-01 6.46E-03 2.46E-03 8.14E-05 4.83E-03 2.82E-03 1.34E-03 4.47E-18 2.24E-03 1.08E-02 3.12E-02 5.72E-03 2.62E-03 1.84E-03 1.38E-03 9.91E-03 9.27E-04 3.01E-02 4.04E-05 2.02E-03 1.88E-03 2.18E-02 2.32E-03 7.91E-03 9.87E-03 5.25E-03 3.13E-03 1.05E-01 3.20E-03 2.87E-03 8.34E-02 6.28E-03 4.50E-04 1.78E-04 1.77E-02 7.11E-02 1.31E-03 4.07E-03 1.70E-02 4.98E-03 2.64E-03 4.56E-03 9.50E-03 5.73E-03 2.79E-03 0.000003247249 0.006209066076 +T>C CTG C[T>C]G 3.60E-04 2.23E-16 1.01E-02 5.50E-03 2.08E-02 5.32E-03 1.04E-04 7.30E-04 2.17E-03 9.35E-04 1.26E-03 1.54E-02 1.05E-03 2.53E-05 1.31E-04 3.74E-02 2.22E-16 4.47E-03 1.39E-03 9.61E-03 8.73E-02 3.92E-03 1.62E-03 4.98E-04 2.61E-02 1.44E-02 2.03E-03 3.89E-04 4.22E-03 1.34E-02 7.87E-02 5.66E-03 2.49E-03 3.91E-03 1.27E-03 4.46E-03 1.84E-03 4.00E-02 8.11E-04 1.56E-03 1.85E-03 9.95E-03 2.54E-03 7.77E-03 1.05E-02 5.57E-03 3.56E-03 9.25E-03 3.38E-02 1.56E-03 5.04E-02 3.10E-03 3.21E-05 1.08E-04 2.42E-03 2.93E-03 1.23E-03 8.49E-03 1.93E-01 9.49E-04 4.81E-04 8.30E-03 5.93E-03 1.64E-03 5.80E-04 0.003628314755 0.000839951905 +T>C CTT C[T>C]T 4.26E-05 1.86E-04 1.58E-02 2.56E-03 1.49E-02 1.27E-03 1.82E-03 5.73E-03 4.31E-02 3.97E-02 6.46E-03 3.29E-02 2.44E-06 8.15E-04 8.45E-05 4.59E-02 1.12E-04 2.06E-03 1.75E-03 1.55E-02 4.26E-01 1.83E-02 2.56E-03 3.91E-04 6.90E-03 2.17E-02 5.36E-04 4.71E-05 3.63E-03 8.96E-03 5.55E-02 3.90E-03 3.67E-04 1.78E-03 4.10E-03 1.38E-02 1.09E-03 3.07E-03 1.59E-03 3.18E-03 2.16E-03 5.04E-02 4.27E-03 8.59E-03 1.36E-02 7.87E-03 3.24E-03 9.45E-03 7.71E-03 6.02E-04 9.58E-02 5.45E-03 6.77E-05 9.74E-05 1.38E-03 6.64E-03 2.34E-03 5.42E-03 2.69E-02 6.84E-04 2.06E-04 2.43E-02 2.82E-02 1.22E-02 2.10E-03 0.000918581801 0.016913140039 +T>C GTA G[T>C]A 1.05E-03 2.23E-16 9.98E-03 2.90E-03 1.41E-02 2.57E-03 1.01E-04 2.66E-04 2.22E-16 8.00E-04 2.60E-03 9.52E-03 2.20E-03 1.47E-02 8.09E-04 7.11E-02 2.87E-04 1.10E-02 1.29E-02 2.06E-03 1.23E-04 5.95E-05 7.08E-04 9.54E-04 2.76E-03 2.23E-01 7.21E-04 2.18E-04 3.70E-03 1.75E-02 8.35E-02 4.78E-03 4.91E-04 1.08E-03 9.35E-04 4.53E-03 9.14E-03 1.22E-02 1.09E-04 5.65E-04 2.34E-03 3.07E-02 1.70E-03 7.47E-03 6.01E-03 6.06E-03 5.82E-03 7.50E-18 2.70E-02 6.54E-04 2.21E-02 4.17E-04 1.57E-04 6.59E-05 1.38E-03 1.18E-03 2.42E-03 5.61E-03 1.14E-02 2.61E-03 7.30E-04 3.86E-03 2.18E-03 7.10E-04 7.61E-04 0.000000000000 0.021590706956 +T>C GTC G[T>C]C 1.90E-03 2.74E-05 5.64E-03 1.18E-03 7.94E-03 1.11E-03 7.41E-05 2.22E-16 4.23E-04 2.32E-03 2.62E-03 9.78E-03 6.28E-03 5.33E-03 8.60E-04 3.04E-02 1.82E-04 6.54E-03 1.16E-02 1.19E-03 1.49E-02 1.50E-03 2.26E-03 3.71E-04 2.26E-03 6.63E-02 1.24E-03 4.18E-04 3.65E-03 4.05E-03 2.48E-02 1.96E-03 5.87E-04 3.59E-03 5.55E-04 6.57E-03 7.67E-03 7.94E-03 6.46E-04 2.03E-03 1.40E-03 1.82E-02 2.16E-03 6.89E-03 4.58E-03 3.74E-03 3.31E-03 2.19E-02 1.16E-03 5.70E-04 5.76E-02 1.09E-03 1.29E-04 1.51E-04 5.38E-03 2.27E-03 2.05E-03 6.68E-03 4.43E-03 3.17E-03 2.73E-05 2.29E-03 7.80E-04 3.18E-03 6.35E-04 0.000865945066 0.011606134984 +T>C GTG G[T>C]G 1.17E-03 1.07E-04 1.09E-02 2.37E-03 1.50E-02 2.45E-03 7.25E-05 5.29E-04 2.32E-04 2.57E-03 2.81E-03 6.31E-03 2.23E-16 1.38E-03 5.61E-04 4.15E-02 1.95E-04 1.10E-02 5.95E-03 4.28E-03 3.57E-03 1.01E-03 3.98E-03 9.53E-04 4.06E-03 1.17E-01 5.81E-04 4.68E-18 2.67E-03 1.34E-02 7.12E-02 1.23E-03 7.31E-04 2.99E-03 5.01E-04 5.13E-03 9.62E-03 2.07E-01 4.40E-04 1.91E-04 1.84E-03 9.83E-03 1.87E-03 5.74E-03 5.65E-03 3.51E-03 3.21E-03 1.20E-03 1.73E-02 9.07E-04 3.53E-02 3.10E-03 4.67E-05 6.53E-05 3.71E-03 4.56E-03 9.14E-04 2.56E-03 1.21E-01 6.01E-03 1.65E-03 4.72E-03 1.11E-02 9.86E-04 5.00E-04 0.000197907041 0.006462687955 +T>C GTT G[T>C]T 7.13E-05 1.25E-05 1.02E-02 7.55E-04 1.37E-02 9.06E-04 8.11E-04 6.85E-03 7.07E-03 3.18E-01 6.29E-03 9.86E-03 5.29E-03 1.15E-02 2.37E-04 4.63E-02 2.22E-16 1.12E-02 5.86E-03 2.40E-03 5.24E-03 1.47E-03 3.15E-03 2.36E-03 9.28E-04 1.33E-01 8.34E-04 7.99E-04 3.99E-03 1.42E-02 5.52E-02 3.75E-03 8.51E-04 1.55E-03 4.45E-04 4.69E-03 1.29E-02 9.71E-03 2.22E-16 4.21E-04 2.65E-03 4.00E-02 3.05E-03 7.51E-03 7.31E-03 3.89E-03 2.39E-03 5.18E-04 1.11E-02 1.39E-03 6.07E-02 3.19E-03 1.10E-04 1.75E-04 1.17E-03 4.01E-03 3.11E-03 6.99E-03 5.41E-03 1.26E-02 2.58E-03 5.36E-03 2.02E-03 1.19E-03 6.96E-04 0.003662473198 0.054089001127 +T>C TTA T[T>C]A 2.55E-04 2.23E-16 1.52E-02 2.41E-03 1.80E-02 1.48E-03 2.15E-03 6.00E-03 3.02E-02 8.12E-02 2.08E-03 1.40E-02 7.30E-04 8.86E-03 1.13E-04 8.61E-02 2.21E-05 6.27E-03 3.42E-03 1.30E-02 2.09E-03 1.06E-03 1.80E-03 1.24E-03 1.38E-02 8.42E-02 4.63E-03 7.77E-18 1.46E-03 1.45E-02 4.23E-02 1.72E-03 1.31E-03 2.59E-03 5.44E-04 4.59E-03 8.97E-04 1.10E-02 1.40E-03 3.68E-04 2.97E-03 4.77E-02 2.11E-03 5.94E-03 1.02E-02 6.36E-02 6.82E-03 1.37E-04 1.99E-02 1.28E-03 9.30E-03 1.37E-03 6.05E-04 1.73E-04 1.09E-03 4.46E-03 2.77E-03 7.11E-03 4.73E-03 4.88E-03 5.68E-04 4.90E-03 3.31E-03 2.05E-03 2.40E-04 0.000432939443 0.012963549217 +T>C TTC T[T>C]C 3.39E-03 4.35E-05 8.99E-03 5.03E-04 9.71E-03 1.09E-03 5.96E-04 1.73E-03 2.09E-02 1.43E-02 2.64E-03 1.36E-02 5.17E-03 8.10E-05 4.67E-04 4.63E-02 2.49E-05 2.88E-03 5.92E-03 3.67E-03 1.53E-02 1.10E-03 6.18E-03 5.53E-04 1.66E-02 5.48E-02 2.22E-16 1.90E-04 3.00E-03 7.41E-03 3.14E-02 3.49E-03 2.05E-03 1.50E-03 2.86E-04 1.03E-02 1.22E-03 1.25E-02 6.24E-03 8.22E-04 2.28E-03 4.51E-02 2.19E-03 6.44E-03 7.55E-03 2.68E-02 3.03E-03 3.59E-02 1.05E-02 1.10E-03 5.43E-02 1.75E-02 4.04E-04 8.47E-05 2.90E-02 3.93E-03 2.18E-03 5.03E-03 8.19E-03 9.80E-04 1.32E-03 2.67E-02 1.96E-02 2.24E-03 1.09E-03 0.000538464673 0.023324448028 +T>C TTG T[T>C]G 4.16E-04 1.17E-04 6.93E-03 1.74E-03 1.27E-02 2.13E-03 3.19E-04 3.81E-03 1.29E-02 2.28E-02 2.22E-16 9.31E-03 3.63E-04 6.68E-04 1.55E-04 4.00E-02 9.98E-05 4.31E-03 1.32E-03 7.23E-03 2.35E-03 1.21E-03 3.26E-03 1.08E-03 1.20E-02 2.76E-02 1.22E-03 3.02E-04 2.03E-03 4.89E-03 3.03E-02 1.15E-03 1.41E-03 3.79E-04 2.03E-04 4.01E-03 1.69E-03 3.20E-01 1.10E-03 4.38E-04 1.38E-03 1.00E-02 1.92E-03 4.98E-03 6.01E-03 2.05E-02 3.41E-03 2.78E-05 1.91E-02 1.24E-03 2.37E-02 1.58E-03 2.97E-04 6.31E-05 1.02E-03 2.47E-03 1.07E-03 4.72E-03 8.84E-02 4.16E-03 1.85E-03 2.96E-03 2.16E-03 1.35E-03 1.09E-04 0.000022365153 0.003823534542 +T>C TTT T[T>C]T 4.33E-03 3.58E-05 1.39E-02 6.36E-04 1.85E-02 1.74E-03 8.12E-04 2.97E-03 8.81E-02 4.31E-02 4.57E-03 3.84E-02 3.25E-03 2.51E-05 1.06E-04 5.97E-02 5.31E-04 2.92E-03 1.35E-03 8.39E-03 2.10E-02 1.00E-03 3.37E-03 1.47E-03 1.93E-02 4.07E-02 2.22E-16 7.32E-18 3.67E-03 1.70E-02 5.74E-02 1.53E-03 2.06E-03 8.22E-04 4.45E-04 1.21E-02 6.84E-04 9.12E-03 7.08E-03 1.06E-03 2.80E-03 6.14E-02 3.06E-03 9.48E-03 1.02E-02 4.61E-02 2.36E-03 1.84E-03 3.71E-02 5.45E-04 3.65E-02 1.15E-02 5.32E-04 2.08E-04 5.11E-03 2.13E-02 2.00E-03 2.19E-03 1.25E-02 8.87E-04 2.85E-04 1.95E-01 3.20E-02 2.61E-03 1.32E-03 0.009820763708 0.094054377313 +T>G ATA A[T>G]A 1.72E-04 2.38E-04 3.95E-03 1.05E-03 3.86E-03 2.57E-05 4.73E-04 8.44E-05 1.19E-02 3.70E-03 1.64E-03 4.51E-02 1.92E-03 3.47E-05 2.18E-04 2.01E-03 6.14E-05 2.12E-04 4.68E-04 1.12E-02 8.51E-04 1.41E-03 7.21E-04 2.33E-03 1.05E-05 3.92E-04 2.33E-03 8.28E-18 3.21E-03 5.28E-03 2.92E-03 1.14E-03 9.87E-03 4.07E-04 3.90E-05 3.68E-03 3.86E-04 9.79E-04 2.82E-03 3.05E-03 1.09E-03 2.17E-02 1.15E-03 3.88E-03 7.23E-03 7.53E-03 1.20E-03 2.63E-03 2.40E-08 1.17E-04 1.00E-04 1.71E-04 5.17E-04 1.96E-04 7.43E-04 7.23E-04 1.73E-03 4.59E-03 3.87E-05 2.62E-04 1.21E-04 7.06E-03 1.35E-02 1.79E-03 2.50E-02 0.000127137772 0.023838221813 +T>G ATC A[T>G]C 2.07E-04 7.46E-05 2.60E-03 1.59E-04 2.60E-03 2.04E-04 2.47E-04 9.32E-04 1.05E-03 2.66E-03 6.68E-04 6.93E-03 1.24E-03 5.33E-05 4.67E-05 6.64E-04 2.22E-16 2.97E-03 4.15E-04 4.41E-03 7.00E-04 4.48E-03 8.58E-04 1.89E-03 2.13E-05 4.37E-04 5.09E-05 5.43E-18 1.40E-03 0.00E+00 2.53E-03 9.59E-04 1.73E-02 8.17E-04 1.10E-04 2.48E-03 4.29E-04 3.02E-04 4.62E-04 9.66E-04 6.23E-04 1.06E-02 1.07E-03 2.97E-03 7.05E-03 1.64E-03 4.05E-04 4.07E-03 3.26E-05 5.84E-04 8.00E-04 1.72E-03 4.10E-05 8.28E-05 6.07E-04 4.09E-03 5.29E-04 2.90E-03 1.58E-03 9.20E-04 7.99E-18 7.89E-04 7.88E-04 1.56E-03 1.05E-02 0.001270955861 0.003434920439 +T>G ATG A[T>G]G 2.68E-04 2.05E-06 6.30E-03 1.42E-03 7.94E-03 1.07E-04 2.76E-04 1.47E-03 6.04E-04 1.06E-02 4.77E-03 5.33E-03 3.20E-04 5.23E-04 1.79E-04 8.08E-04 8.25E-05 7.09E-04 1.85E-04 4.62E-03 7.19E-04 9.90E-04 1.99E-03 1.77E-03 2.69E-05 1.87E-04 2.95E-03 5.68E-18 2.06E-03 7.14E-03 2.29E-03 6.77E-05 7.68E-03 4.20E-04 4.10E-04 4.02E-03 1.27E-03 4.75E-04 1.97E-04 4.48E-03 9.36E-04 1.68E-02 2.07E-03 7.66E-03 8.06E-03 2.70E-03 6.37E-04 3.49E-02 7.47E-06 9.84E-04 1.60E-03 3.68E-03 3.51E-04 1.26E-04 3.94E-03 2.78E-02 1.19E-03 5.06E-03 1.15E-03 1.45E-01 1.27E-05 1.23E-03 2.71E-03 1.70E-03 2.61E-02 0.000952698782 0.004485500819 +T>G ATT A[T>G]T 1.12E-04 3.76E-06 3.97E-03 2.16E-04 4.83E-03 3.86E-04 3.09E-04 7.33E-04 2.22E-16 1.43E-02 7.40E-04 2.39E-02 9.22E-03 2.22E-16 2.85E-04 1.28E-03 3.20E-04 1.11E-02 3.63E-03 7.96E-03 1.25E-02 6.91E-02 1.84E-03 1.62E-03 5.82E-05 6.95E-05 4.18E-05 7.43E-18 4.71E-03 0.00E+00 5.93E-03 2.56E-04 1.15E-01 8.10E-04 7.94E-04 7.83E-04 6.45E-18 7.58E-04 1.15E-03 2.63E-03 9.84E-04 2.47E-02 2.86E-03 6.42E-03 1.80E-02 7.61E-03 9.11E-04 5.64E-03 1.42E-03 1.66E-04 6.00E-04 8.08E-03 1.99E-04 1.26E-04 1.03E-04 2.13E-03 1.86E-03 2.06E-03 3.40E-04 2.28E-03 5.75E-03 5.97E-03 2.08E-03 3.44E-03 1.64E-02 0.001764975843 0.003178596391 +T>G CTA C[T>G]A 3.55E-05 1.53E-04 4.37E-03 8.70E-04 2.59E-03 4.95E-05 8.42E-05 3.59E-04 3.28E-03 1.48E-03 1.22E-03 2.60E-02 1.55E-04 2.27E-04 2.22E-16 8.93E-04 4.14E-05 4.85E-05 2.06E-04 3.96E-03 3.10E-04 2.05E-03 1.11E-04 7.14E-04 9.63E-04 4.35E-06 4.91E-03 6.85E-18 1.43E-03 0.00E+00 1.42E-03 0.00E+00 1.46E-02 7.81E-04 1.98E-04 1.97E-03 5.81E-05 7.28E-04 1.06E-03 3.71E-03 4.78E-04 2.60E-03 9.83E-04 5.30E-03 3.35E-03 3.47E-03 8.70E-04 2.73E-03 2.34E-04 1.02E-04 0.00E+00 1.37E-04 1.34E-04 1.06E-04 8.94E-04 2.78E-03 8.03E-04 1.49E-03 4.36E-03 1.65E-03 5.82E-03 1.40E-04 5.03E-04 1.01E-03 3.23E-03 0.000897193499 0.003736474707 +T>G CTC C[T>G]C 2.12E-04 1.55E-04 7.04E-03 4.41E-04 4.61E-03 7.84E-04 1.72E-04 7.92E-04 5.58E-03 4.98E-05 1.95E-03 7.41E-03 2.23E-16 1.15E-03 2.22E-16 1.14E-03 2.82E-06 1.21E-03 1.57E-04 1.08E-03 1.04E-03 3.14E-02 1.99E-03 2.09E-03 1.60E-03 5.44E-05 8.80E-04 1.48E-04 8.80E-04 2.89E-03 4.94E-03 3.81E-04 2.21E-02 5.69E-06 2.15E-04 1.43E-03 4.50E-04 9.49E-04 2.22E-16 5.18E-04 5.66E-04 2.38E-03 1.41E-03 7.39E-03 5.67E-03 2.41E-03 7.53E-04 7.26E-03 2.53E-03 2.81E-04 1.80E-03 5.15E-05 9.28E-05 2.67E-05 6.18E-05 2.56E-03 7.75E-04 4.24E-03 1.89E-02 4.66E-04 3.93E-07 8.47E-04 1.04E-03 2.62E-03 4.16E-03 0.002148873221 0.002478170057 +T>G CTG C[T>G]G 1.28E-04 1.21E-04 1.07E-02 3.79E-03 6.13E-03 9.24E-04 2.23E-16 1.29E-03 1.19E-03 2.58E-05 4.70E-03 1.42E-02 5.35E-05 4.79E-04 2.22E-16 5.93E-04 2.22E-16 4.35E-04 2.72E-04 2.24E-03 1.94E-06 1.37E-02 2.93E-03 1.33E-03 2.71E-03 2.01E-05 8.03E-03 6.52E-05 3.04E-03 1.18E-02 5.56E-03 4.03E-04 1.55E-02 3.32E-04 7.85E-05 1.50E-03 1.09E-03 1.07E-03 4.36E-04 6.36E-03 8.87E-04 3.77E-03 1.59E-03 9.83E-03 5.59E-03 3.04E-03 5.68E-03 4.65E-02 3.47E-03 6.49E-04 1.60E-03 3.67E-03 1.04E-04 1.12E-04 3.66E-03 5.93E-03 7.96E-04 2.98E-03 2.21E-02 1.13E-01 4.45E-03 2.19E-03 6.99E-04 2.02E-03 7.11E-03 0.000788671403 0.001120299176 +T>G CTT C[T>G]T 1.71E-04 2.03E-04 7.03E-03 1.20E-03 7.30E-03 1.30E-03 2.65E-05 3.68E-06 3.40E-03 1.56E-04 5.74E-04 5.65E-02 1.30E-03 5.23E-03 1.33E-04 3.44E-04 5.55E-05 9.62E-04 2.49E-03 2.54E-03 5.31E-03 5.50E-01 4.14E-03 2.20E-03 5.11E-03 1.85E-04 1.19E-03 2.47E-04 4.71E-03 8.55E-03 7.80E-03 1.44E-03 1.01E-01 7.67E-04 2.65E-04 9.49E-04 6.76E-04 1.92E-04 6.55E-07 2.71E-03 1.07E-03 4.11E-03 6.88E-03 4.94E-03 1.31E-02 1.05E-02 3.48E-03 6.26E-18 3.84E-04 7.28E-04 2.00E-03 1.07E-04 6.57E-05 9.29E-05 4.71E-04 2.30E-03 8.63E-04 2.72E-03 8.86E-04 1.18E-03 6.78E-18 5.16E-03 4.73E-04 2.12E-02 1.80E-05 0.000000000000 0.001756870383 +T>G GTA G[T>G]A 2.23E-16 2.09E-04 4.42E-03 5.98E-04 2.52E-03 4.35E-05 9.06E-05 3.23E-04 2.48E-03 7.48E-05 1.31E-03 8.30E-03 2.04E-04 4.81E-04 9.57E-05 4.12E-04 8.77E-05 7.79E-05 2.03E-04 9.02E-04 4.95E-04 2.81E-04 8.70E-04 6.36E-04 2.22E-16 2.86E-04 1.59E-03 6.26E-18 1.07E-03 5.55E-03 1.37E-03 0.00E+00 1.16E-03 4.49E-05 1.88E-04 3.04E-04 1.15E-03 5.81E-04 3.65E-04 1.76E-03 1.85E-04 1.18E-02 5.04E-04 3.33E-03 2.49E-03 1.80E-03 1.14E-03 6.11E-02 7.68E-18 4.40E-04 0.00E+00 2.20E-02 7.64E-06 6.61E-05 8.67E-03 2.19E-03 1.13E-03 4.38E-03 1.70E-04 5.67E-03 6.72E-18 1.40E-03 8.07E-03 1.23E-03 2.82E-02 0.000018879250 0.007699623603 +T>G GTC G[T>G]C 2.23E-16 1.33E-04 2.34E-03 2.53E-04 1.71E-03 2.13E-04 1.21E-04 3.21E-04 1.66E-03 2.23E-05 6.56E-04 5.85E-03 8.33E-04 9.42E-04 2.22E-16 2.13E-04 2.22E-16 2.10E-03 5.80E-04 9.01E-04 2.04E-04 6.25E-03 3.70E-05 7.03E-04 6.65E-05 5.33E-04 2.36E-04 8.69E-05 1.53E-03 0.00E+00 1.21E-03 5.08E-05 1.93E-03 9.17E-05 3.53E-04 8.72E-04 7.40E-04 6.37E-04 2.22E-16 5.07E-03 3.13E-04 6.86E-03 9.39E-04 5.80E-03 2.24E-03 9.50E-04 7.05E-05 7.56E-02 1.83E-05 5.20E-04 1.00E-04 1.04E-02 1.35E-04 4.37E-05 9.59E-03 5.30E-03 5.61E-04 1.74E-03 1.53E-03 3.20E-03 9.19E-07 1.71E-04 2.69E-03 1.65E-03 2.88E-02 0.001229435537 0.000800067973 +T>G GTG G[T>G]G 3.48E-04 3.71E-05 1.09E-02 2.43E-03 5.30E-03 2.74E-04 3.25E-04 2.41E-03 6.03E-03 3.80E-03 3.97E-03 3.97E-03 2.23E-16 1.73E-03 1.30E-04 4.96E-04 4.26E-04 7.81E-04 3.47E-04 6.75E-04 8.35E-04 1.48E-03 5.83E-03 5.10E-04 8.70E-05 2.13E-04 4.50E-04 1.57E-04 3.13E-03 8.69E-03 2.35E-03 4.74E-03 3.13E-03 7.70E-04 1.38E-03 2.55E-03 3.01E-03 5.42E-03 5.65E-05 4.04E-03 1.53E-03 9.83E-03 2.16E-03 7.72E-03 4.45E-03 1.20E-03 4.10E-04 2.41E-01 1.03E-04 1.79E-04 1.20E-03 2.72E-02 6.63E-05 1.47E-04 3.51E-02 7.62E-02 1.37E-03 4.73E-03 7.45E-18 2.99E-01 6.72E-18 8.61E-04 2.34E-02 2.29E-03 6.62E-01 0.000212751233 0.001946513805 +T>G GTT G[T>G]T 1.46E-05 2.23E-16 5.83E-03 2.52E-04 2.35E-03 7.87E-04 8.35E-04 1.83E-03 6.75E-03 6.84E-03 1.29E-03 1.94E-02 2.21E-03 5.16E-03 1.54E-04 1.65E-04 2.89E-06 2.25E-03 1.39E-03 2.39E-03 7.24E-03 1.14E-01 2.14E-03 3.41E-04 3.56E-03 2.59E-03 1.96E-05 5.78E-18 2.68E-03 2.77E-03 6.05E-03 2.30E-03 2.06E-02 1.15E-03 1.60E-04 2.81E-03 7.85E-04 4.51E-04 4.17E-04 3.35E-03 4.89E-04 1.71E-02 3.34E-03 5.94E-03 5.48E-03 3.47E-03 9.20E-04 7.46E-02 2.80E-03 4.96E-04 6.00E-04 8.84E-02 1.15E-05 1.02E-04 3.65E-02 2.09E-03 8.64E-04 2.03E-03 1.21E-05 1.44E-03 1.14E-04 2.83E-03 1.69E-02 7.45E-03 4.74E-02 0.001340078646 0.002927905616 +T>G TTA T[T>G]A 2.23E-16 1.67E-05 7.25E-03 3.77E-04 5.22E-03 1.05E-04 1.28E-04 9.55E-04 1.93E-02 2.11E-04 2.22E-16 6.57E-02 2.69E-03 1.13E-02 8.51E-05 1.63E-03 1.84E-04 9.92E-05 2.31E-04 9.78E-03 2.22E-16 1.22E-05 6.96E-04 1.66E-03 2.22E-16 4.65E-04 5.06E-03 1.86E-04 1.23E-04 2.08E-03 1.43E-03 1.19E-03 4.23E-02 4.67E-04 1.18E-04 2.25E-03 2.26E-05 4.68E-04 2.22E-16 4.29E-03 7.88E-04 1.83E-02 1.17E-03 8.39E-03 8.46E-03 4.19E-02 1.15E-03 2.04E-04 7.68E-18 2.85E-04 7.00E-04 2.41E-03 2.50E-04 1.50E-04 3.27E-04 2.55E-03 1.43E-03 1.30E-03 3.24E-05 6.06E-03 9.46E-03 3.22E-03 7.98E-04 1.60E-03 1.61E-03 0.001875698241 0.007106411217 +T>G TTC T[T>G]C 5.51E-05 7.04E-05 6.28E-03 1.74E-04 6.56E-03 2.87E-04 1.16E-04 1.55E-03 1.74E-02 1.15E-04 1.14E-03 8.62E-03 2.23E-16 5.55E-03 6.73E-05 1.13E-03 2.22E-16 1.20E-03 2.94E-04 5.51E-03 1.16E-04 8.75E-03 2.10E-03 2.02E-03 2.22E-16 3.79E-04 7.52E-04 5.27E-18 2.64E-03 5.79E-04 1.72E-03 2.80E-04 3.57E-02 9.93E-05 9.64E-05 2.38E-03 2.24E-04 1.64E-04 2.22E-16 1.94E-03 7.44E-04 1.95E-02 9.03E-04 5.08E-03 1.14E-02 1.55E-02 2.74E-04 8.25E-03 7.68E-18 1.35E-04 1.00E-03 2.25E-05 2.22E-04 1.38E-04 6.55E-04 3.47E-03 1.12E-03 4.36E-03 7.06E-04 5.65E-03 1.00E-06 3.96E-03 1.59E-03 2.33E-03 1.06E-02 0.000737916543 0.006404453857 +T>G TTG T[T>G]G 5.83E-04 9.54E-05 8.05E-03 2.32E-03 6.94E-03 3.24E-04 2.23E-16 1.35E-03 7.64E-03 1.25E-04 3.09E-03 1.09E-02 2.16E-05 2.76E-03 1.01E-04 8.75E-04 3.67E-05 1.14E-04 1.48E-04 5.24E-03 9.20E-04 4.78E-03 1.45E-03 2.07E-03 2.79E-03 1.31E-04 5.57E-03 1.82E-04 3.04E-03 9.43E-03 2.84E-03 2.35E-03 1.40E-02 1.80E-04 8.13E-04 5.35E-03 8.18E-04 9.59E-04 1.52E-03 4.82E-03 9.02E-04 3.02E-02 1.90E-03 7.28E-03 8.66E-03 1.94E-02 2.93E-03 2.28E-02 9.17E-04 7.08E-04 9.00E-04 1.54E-03 3.50E-04 1.12E-04 8.72E-03 2.76E-03 1.48E-03 6.15E-03 7.69E-03 7.95E-02 1.01E-04 5.40E-03 6.74E-03 1.96E-03 2.39E-02 0.000000000000 0.003409999931 +T>G TTT T[T>G]T 2.23E-16 2.23E-16 1.05E-02 5.68E-04 1.35E-02 1.01E-03 8.29E-05 1.77E-03 2.17E-02 1.66E-04 9.96E-04 6.39E-02 1.89E-02 9.09E-02 5.55E-05 2.21E-03 1.89E-05 6.05E-04 5.99E-03 1.58E-02 4.58E-03 1.22E-01 5.16E-03 4.23E-03 1.51E-03 2.22E-16 5.95E-04 7.32E-18 3.96E-03 7.87E-03 9.45E-03 1.40E-04 4.79E-01 9.28E-04 8.89E-03 7.30E-03 6.35E-04 2.25E-03 2.32E-04 3.62E-03 1.81E-03 2.91E-02 5.29E-03 1.09E-02 2.50E-02 8.79E-02 1.74E-03 1.32E-03 9.00E-03 7.24E-04 1.00E-03 3.62E-03 3.20E-07 3.64E-04 1.60E-03 2.91E-03 2.53E-03 7.05E-03 4.99E-04 4.12E-02 2.90E-02 1.19E-01 2.17E-02 1.30E-17 3.18E-02 0.006603134330 0.012708761755
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/sigmatrix.tab Thu Sep 24 01:32:52 2020 +0000 @@ -0,0 +1,97 @@ +substitution context NewSig_1 NewSig_2 NewSig_3 NewSig_4 +C>A A.A 2.012349e-02 2.099063e-02 1.788529e-02 2.529973e-02 +C>A A.C 1.232623e-02 5.099845e-05 2.019020e-02 8.344265e-03 +C>A A.G 2.056317e-03 5.061512e-03 5.110667e-03 5.598599e-04 +C>A A.T 4.276274e-03 7.030586e-03 1.433976e-02 9.044799e-03 +C>A C.A 9.858499e-03 6.774294e-03 1.254817e-02 1.109854e-02 +C>A C.C 7.182083e-03 5.137412e-03 1.754580e-02 7.871756e-03 +C>A C.G 3.071657e-03 7.744685e-04 3.478215e-03 3.033573e-03 +C>A C.T 9.805120e-04 1.022892e-02 8.612445e-03 1.089991e-02 +C>A G.A 1.295094e-02 5.191677e-03 2.838657e-03 1.229298e-02 +C>A G.C 4.262714e-03 5.183579e-03 8.941540e-03 5.390685e-03 +C>A G.G 3.769228e-03 1.557726e-03 1.699600e-03 3.945304e-03 +C>A G.T 6.573060e-03 1.031818e-04 1.059791e-02 7.185424e-03 +C>A T.A 3.862713e-03 1.624881e-02 5.519485e-03 1.246359e-02 +C>A T.C 8.824563e-03 6.792814e-03 4.042968e-03 1.212436e-02 +C>A T.G 1.024188e-03 9.815808e-04 2.029646e-03 1.087012e-03 +C>A T.T 1.181704e-02 9.618044e-03 1.665114e-02 1.307952e-02 +C>G A.A 1.983228e-02 1.270519e-02 1.655687e-02 1.398506e-02 +C>G A.C 4.742892e-11 1.043116e-02 9.102239e-03 2.314023e-20 +C>G A.G 2.906055e-03 1.687383e-03 5.265593e-03 2.218107e-03 +C>G A.T 6.407465e-03 8.581278e-03 1.079483e-02 9.668306e-03 +C>G C.A 3.411641e-03 6.888991e-03 7.212837e-03 7.949635e-03 +C>G C.C 1.962245e-04 9.715947e-03 1.158418e-12 7.156965e-03 +C>G C.G 3.300401e-20 1.855024e-03 4.346525e-03 6.200559e-03 +C>G C.T 9.865314e-03 1.922285e-03 6.273441e-03 6.226190e-03 +C>G G.A 1.351834e-19 2.119713e-03 1.072168e-02 8.229779e-03 +C>G G.C 2.379848e-03 4.610717e-03 8.965747e-04 6.505033e-03 +C>G G.G 6.979718e-04 1.181697e-03 4.111756e-03 2.523959e-03 +C>G G.T 2.220903e-03 5.934769e-03 8.611327e-03 6.739344e-03 +C>G T.A 3.709345e-03 8.786940e-03 7.620791e-03 8.983741e-03 +C>G T.C 3.827093e-03 8.865683e-03 6.057793e-03 6.240498e-03 +C>G T.G 1.899263e-04 4.938065e-03 3.040335e-03 1.626378e-03 +C>G T.T 3.860261e-03 2.446381e-02 2.353559e-02 1.511199e-02 +C>T A.A 3.499419e-02 3.714546e-02 4.085734e-02 3.151538e-02 +C>T A.C 1.719840e-02 1.389005e-02 5.154001e-03 1.603745e-02 +C>T A.G 7.482535e-02 1.348050e-02 3.052063e-02 1.592390e-02 +C>T A.T 1.607143e-02 1.438585e-02 1.967215e-02 1.741898e-02 +C>T C.A 1.606874e-02 1.435234e-02 1.105389e-02 1.125796e-02 +C>T C.C 1.700219e-02 9.214402e-03 1.282668e-02 1.377429e-02 +C>T C.G 4.356691e-02 1.624586e-02 1.169686e-02 1.963077e-02 +C>T C.T 2.301602e-02 3.266347e-02 1.574218e-02 2.039183e-02 +C>T G.A 1.970589e-02 7.742080e-03 1.178227e-02 1.297792e-02 +C>T G.C 1.466426e-02 1.914382e-02 6.909098e-03 1.355502e-02 +C>T G.G 3.701827e-02 2.542796e-02 1.262381e-02 3.190790e-02 +C>T G.T 1.382222e-02 2.392818e-02 6.174897e-03 1.508942e-02 +C>T T.A 1.143013e-02 1.914536e-02 1.002998e-02 7.458921e-03 +C>T T.C 1.879514e-02 2.009898e-02 1.421423e-02 1.556176e-02 +C>T T.G 3.061491e-02 4.743450e-03 1.167740e-02 7.144683e-03 +C>T T.T 3.133938e-02 2.219653e-02 3.807693e-02 3.192865e-02 +T>A A.A 1.841481e-02 8.914346e-03 1.741295e-02 1.361688e-02 +T>A A.C 3.425691e-03 8.698638e-03 3.992626e-03 5.443164e-03 +T>A A.G 9.072656e-03 1.149533e-02 1.354019e-03 8.223373e-03 +T>A A.T 9.659453e-03 1.830189e-02 1.174139e-02 1.710128e-02 +T>A C.A 2.727069e-03 7.915424e-03 5.772823e-03 4.530720e-03 +T>A C.C 1.215316e-02 3.470147e-03 7.886743e-03 1.369393e-02 +T>A C.G 3.791221e-03 6.605963e-03 3.294232e-03 8.818173e-03 +T>A C.T 6.289729e-03 1.435186e-02 3.597548e-03 1.211551e-02 +T>A G.A 6.615841e-04 4.146662e-03 4.933783e-03 4.863214e-03 +T>A G.C 1.515807e-03 4.210462e-03 3.382936e-03 9.183128e-04 +T>A G.G 1.070023e-02 1.089710e-02 5.492536e-03 8.802992e-03 +T>A G.T 8.128051e-03 4.233917e-03 9.103699e-03 1.259684e-02 +T>A T.A 1.476324e-02 6.549494e-03 1.579044e-02 7.620545e-03 +T>A T.C 6.738527e-03 8.767946e-04 7.353978e-03 5.436410e-03 +T>A T.G 2.186518e-03 5.445354e-03 2.568144e-03 7.932364e-03 +T>A T.T 1.942541e-02 1.590353e-02 2.306069e-02 3.009347e-02 +T>C A.A 3.011297e-02 3.375076e-02 4.906885e-02 3.383597e-02 +T>C A.C 9.041893e-03 8.933211e-03 8.243474e-03 6.303632e-03 +T>C A.G 2.247578e-02 9.001629e-03 1.950973e-02 8.972544e-03 +T>C A.T 1.210116e-02 1.578255e-02 1.360358e-02 9.528566e-03 +T>C C.A 6.835997e-03 6.652934e-03 1.036887e-02 7.994706e-03 +T>C C.C 9.462334e-03 6.392714e-03 8.437885e-03 1.653238e-02 +T>C C.G 7.156018e-03 1.612832e-02 1.225799e-02 9.579249e-03 +T>C C.T 1.040136e-02 2.530647e-02 1.208573e-02 1.371705e-02 +T>C G.A 8.743261e-03 1.074754e-02 5.087249e-03 1.090594e-02 +T>C G.C 6.111817e-03 6.456267e-03 3.668932e-20 6.346677e-03 +T>C G.G 1.768834e-02 1.377477e-02 1.512171e-02 1.240640e-02 +T>C G.T 3.605052e-03 1.397132e-02 1.282818e-02 1.036663e-02 +T>C T.A 5.577357e-03 1.122841e-02 7.516272e-03 9.852123e-03 +T>C T.C 2.142753e-02 1.003311e-02 1.311934e-02 1.883301e-02 +T>C T.G 3.231084e-03 7.639140e-03 1.374439e-02 6.010940e-03 +T>C T.T 1.771125e-02 5.247659e-02 2.430165e-02 3.016747e-02 +T>G A.A 1.331124e-02 1.426333e-02 7.805243e-05 7.473665e-03 +T>G A.C 3.887921e-03 1.684454e-03 1.435130e-04 6.445063e-04 +T>G A.G 2.394241e-03 5.040173e-03 6.853239e-03 6.994037e-03 +T>G A.T 6.066623e-03 7.374853e-03 2.079215e-10 5.136694e-03 +T>G C.A 5.000218e-10 8.218020e-03 3.668932e-20 2.314023e-20 +T>G C.C 3.300401e-20 1.904378e-03 4.043369e-03 4.672135e-03 +T>G C.G 4.310666e-03 2.256883e-03 8.181657e-03 1.928646e-03 +T>G C.T 2.128603e-03 9.425709e-04 8.787753e-03 6.815812e-04 +T>G G.A 2.012235e-03 4.628783e-04 4.459546e-03 1.814827e-03 +T>G G.C 3.997247e-03 1.335924e-03 1.270853e-03 3.568581e-03 +T>G G.G 7.790802e-03 1.175435e-02 8.700500e-03 8.985015e-03 +T>G G.T 6.538479e-03 1.329525e-02 4.903674e-03 1.074729e-02 +T>G T.A 2.781217e-03 4.774228e-03 2.965653e-03 7.301491e-03 +T>G T.C 5.182071e-03 5.200467e-03 5.617300e-03 2.629881e-03 +T>G T.G 5.245736e-03 1.345072e-02 1.698469e-02 9.832179e-03 +T>G T.T 2.041928e-02 1.752970e-02 3.978473e-02 1.976735e-02