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1 <html>
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3 <head>
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4 <meta http-equiv=Content-Type content="text/html; charset=windows-1252">
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5 <meta name=Generator content="Microsoft Word 14 (filtered)">
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6 <style>
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7 <!--
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8 /* Font Definitions */
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9 @font-face
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10 {font-family:Calibri;
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11 panose-1:2 15 5 2 2 2 4 3 2 4;}
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12 /* Style Definitions */
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13 p.MsoNormal, li.MsoNormal, div.MsoNormal
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14 {margin-top:0in;
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20 font-family:"Calibri","sans-serif";}
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24 font-size:11.0pt;
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25 font-family:"Calibri","sans-serif";}
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26 .MsoChpDefault
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27 {font-family:"Calibri","sans-serif";}
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28 .MsoPapDefault
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29 {margin-bottom:10.0pt;
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30 line-height:115%;}
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31 @page WordSection1
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32 {size:8.5in 11.0in;
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33 margin:1.0in 1.0in 1.0in 1.0in;}
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34 div.WordSection1
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35 {page:WordSection1;}
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36 -->
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37 </style>
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38
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39 </head>
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40
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41 <body lang=EN-US>
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42
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43 <div class=WordSection1>
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44
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45 <p class=MsoNormalCxSpFirst style='margin-bottom:0in;margin-bottom:.0001pt;
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46 text-align:justify;line-height:normal'><span lang=EN-GB style='font-size:12.0pt;
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47 font-family:"Times New Roman","serif"'>This tab gives information on the
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48 different characteristics of the CDR3.</span></p>
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49
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50 <p class=MsoNormalCxSpMiddle style='margin-bottom:0in;margin-bottom:.0001pt;
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51 text-align:justify;line-height:normal'><b><span lang=EN-GB style='font-size:
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52 12.0pt;font-family:"Times New Roman","serif"'>Graphs</span></b></p>
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53
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54 <p class=MsoNormalCxSpMiddle style='margin-bottom:0in;margin-bottom:.0001pt;
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55 text-align:justify;line-height:normal'><u><span style='font-size:12.0pt;
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56 font-family:"Times New Roman","serif"'>length distribution of CDR3</span></u></p>
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57
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58 <p class=MsoNormalCxSpMiddle style='margin-bottom:0in;margin-bottom:.0001pt;
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59 text-align:justify;line-height:normal'><span style='font-size:12.0pt;
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60 font-family:"Times New Roman","serif"'>Graph visualizing for each donor the
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61 distribution of the CDR3 length in amino acids between all sequences.</span></p>
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62
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63
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64 <p class=MsoNormalCxSpMiddle style='margin-bottom:0in;margin-bottom:.0001pt;
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65 text-align:justify;line-height:normal'><u><span style='font-size:12.0pt;
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66 font-family:"Times New Roman","serif"'>Amino acid composition of CDR3</span></u></p>
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67
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68 <p class=MsoNormalCxSpMiddle style='margin-bottom:0in;margin-bottom:.0001pt;
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69 text-align:justify;line-height:normal'><span lang=EN-GB style='font-size:12.0pt;
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70 font-family:"Times New Roman","serif"'>Bar graph visualizing for each donor how
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71 frequent each amino acid is used in the CDR3 of all sequences. The red colour
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72 in the background indicate positively charged amino acids, and the blue colour
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73 in the background indicate negatively charged amino acids. The amino acids are
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74 ordered from hydrophilic (left) to hydrophobic (right). </span></p>
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75
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76 <p class=MsoNormalCxSpMiddle style='margin-bottom:0in;margin-bottom:.0001pt;
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77 text-align:justify;line-height:normal'><u><span style='font-size:12.0pt;
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78 font-family:"Times New Roman","serif"'>D reading frame</span></u></p>
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79
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80 <p class=MsoNormalCxSpMiddle style='margin-bottom:0in;margin-bottom:.0001pt;
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81 text-align:justify;line-height:normal'><span lang=EN-GB style='font-size:12.0pt;
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82 font-family:"Times New Roman","serif"'>Bar graph visualizing the frequency by
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83 which each D reading frame is used in each donor.</span></p>
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84
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85 <p class=MsoNormalCxSpMiddle style='margin-bottom:0in;margin-bottom:.0001pt;
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86 text-align:justify;line-height:normal'><b><span lang=EN-GB style='font-size:
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87 12.0pt;font-family:"Times New Roman","serif"'>Table</span></b></p>
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88
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89 <p class=MsoNormalCxSpMiddle style='margin-bottom:0in;margin-bottom:.0001pt;
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90 text-align:justify;line-height:normal'><span lang=EN-GB style='font-size:12.0pt;
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91 font-family:"Times New Roman","serif"'>Table showing for each donor the median
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92 CDR3 length.</span></p>
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93
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94 <p class=MsoNormal><span lang=EN-GB> </span></p>
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95
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96 </div>
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97
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98 </body>
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99
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100 </html>
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