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comparison shm_transition.htm @ 81:b6f9a640e098 draft

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author davidvanzessen
date Fri, 19 Feb 2021 15:10:54 +0000
parents a24f8c93583a
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80:a4617f1d1d89 81:b6f9a640e098
1 <html>
2
3 <head>
4 <meta http-equiv=Content-Type content="text/html; charset=windows-1252">
5 <meta name=Generator content="Microsoft Word 14 (filtered)">
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59 <body lang=EN-US link=blue vlink=purple>
60
61 <div class=WordSection1>
62
63 <p class=MsoNormalCxSpFirst style='text-align:justify'><span style='font-size:
64 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These graphs and
65 tables give insight into the targeting and patterns of SHM. This can give
66 insight into the DNA repair pathways used to solve the U:G mismatches
67 introduced by AID. More information on the values found in healthy individuals
68 of different ages can be found in IJspeert and van Schouwenburg et al, PMID:
69 27799928.</span></p>
70
71 <p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span
72 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs
73 </span></b></p>
74
75 <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK93"></a><a
76 name="OLE_LINK92"></a><a name="OLE_LINK91"><u><span style='font-size:12.0pt;
77 line-height:115%;font-family:"Times New Roman","serif"'>Heatmap transition
78 information</span></u></a></p>
79
80 <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK98"></a><a
81 name="OLE_LINK97"><span style='font-size:12.0pt;line-height:115%;font-family:
82 "Times New Roman","serif"'>Heatmaps visualizing for each subclass the frequency
83 of all possible substitutions. On the x-axes the original base is shown, while
84 the y-axes shows the new base. The darker the shade of blue, the more frequent
85 this type of substitution is occurring.  </span></a></p>
86
87 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span
88 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bargraph
89 transition information</span></u></p>
90
91 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size:
92 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bar graph
93 visualizing for each original base the distribution of substitutions into the other
94 bases. A graph is included for each (sub)class. </span></p>
95
96 <p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span
97 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Tables</span></b></p>
98
99 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size:
100 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Transition
101 tables are shown for each (sub)class. All the original bases are listed
102 horizontally, while the new bases are listed vertically. </span></p>
103
104 <p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%;
105 font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van
106 Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen,
107 Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span
108 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation
109 of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and
110 Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a
111 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
112 style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a
113 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
114 style='color:windowtext'>Link</span></a>]</span></p>
115
116 </div>
117
118 </body>
119
120 </html>