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diff shm_transition.htm @ 81:b6f9a640e098 draft

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author davidvanzessen
date Fri, 19 Feb 2021 15:10:54 +0000
parents a24f8c93583a
children ba33b94637ca
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--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/shm_transition.htm	Fri Feb 19 15:10:54 2021 +0000
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+<html>
+
+<head>
+<meta http-equiv=Content-Type content="text/html; charset=windows-1252">
+<meta name=Generator content="Microsoft Word 14 (filtered)">
+<style>
+<!--
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+<body lang=EN-US link=blue vlink=purple>
+
+<div class=WordSection1>
+
+<p class=MsoNormalCxSpFirst style='text-align:justify'><span style='font-size:
+12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These graphs and
+tables give insight into the targeting and patterns of SHM. This can give
+insight into the DNA repair pathways used to solve the U:G mismatches
+introduced by AID. More information on the values found in healthy individuals
+of different ages can be found in IJspeert and van Schouwenburg et al, PMID:
+27799928.</span></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs
+</span></b></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK93"></a><a
+name="OLE_LINK92"></a><a name="OLE_LINK91"><u><span style='font-size:12.0pt;
+line-height:115%;font-family:"Times New Roman","serif"'>Heatmap transition
+information</span></u></a></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK98"></a><a
+name="OLE_LINK97"><span style='font-size:12.0pt;line-height:115%;font-family:
+"Times New Roman","serif"'>Heatmaps visualizing for each subclass the frequency
+of all possible substitutions. On the x-axes the original base is shown, while
+the y-axes shows the new base. The darker the shade of blue, the more frequent
+this type of substitution is occurring.  </span></a></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bargraph
+transition information</span></u></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size:
+12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Bar graph
+visualizing for each original base the distribution of substitutions into the other
+bases. A graph is included for each (sub)class. </span></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><b><span
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Tables</span></b></p>
+
+<p class=MsoNormalCxSpMiddle style='text-align:justify'><span style='font-size:
+12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Transition
+tables are shown for each (sub)class. All the original bases are listed
+horizontally, while the new bases are listed vertically. </span></p>
+
+<p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%;
+font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van
+Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen,
+Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span
+style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation
+of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and
+Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a
+href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
+style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a
+href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
+style='color:windowtext'>Link</span></a>]</span></p>
+
+</div>
+
+</body>
+
+</html>