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date | Mon, 08 Jan 2024 08:50:07 +0000 |
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<html> <head> <meta http-equiv=Content-Type content="text/html; charset=UTF-8"> <meta name=Generator content="Microsoft Word 14 (filtered)"> <style> <!-- /* Font Definitions */ @font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {margin-top:0in; margin-right:0in; margin-bottom:10.0pt; margin-left:0in; line-height:115%; font-size:11.0pt; font-family:"Calibri","sans-serif";} a:link, span.MsoHyperlink {color:blue; text-decoration:underline;} a:visited, span.MsoHyperlinkFollowed {color:purple; text-decoration:underline;} p.MsoNoSpacing, li.MsoNoSpacing, div.MsoNoSpacing {margin:0in; margin-bottom:.0001pt; font-size:11.0pt; font-family:"Calibri","sans-serif";} .MsoChpDefault {font-family:"Calibri","sans-serif";} .MsoPapDefault {margin-bottom:10.0pt; line-height:115%;} @page WordSection1 {size:8.5in 11.0in; margin:1.0in 1.0in 1.0in 1.0in;} div.WordSection1 {page:WordSection1;} --> </style> </head> <body lang=EN-US link=blue vlink=purple> <div class=WordSection1> <p class=MsoNoSpacing style='text-align:justify'><b><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Info</span></b></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The complete dataset:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Allows downloading of the complete parsed data set.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The filtered dataset:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Allows downloading of all parsed IMGT information of all transcripts that passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The alignment info on the unmatched sequences:</span></u><span lang=EN-GB style='font-size: 12.0pt;font-family:"Times New Roman","serif"'> Provides information of the subclass alignment of all unmatched sequences. For each sequence the chunck hit percentage and the nt hit percentage is shown together with the best matched subclass.</span></p> <p class=MsoNoSpacing style='text-align:justify'><b><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>SHM Overview</span></b></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The SHM Overview table as a dataset:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Allows downloading of the SHM Overview table as a data set. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Motif data per sequence ID:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family: "Times New Roman","serif"'> Provides a file that contains information for each transcript on the number of mutations present in WA/TW and RGYW/WRCY motives.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Mutation data per sequence ID: </span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'>Provides a file containing information on the number of sequences bases, the number and location of mutations and the type of mutations found in each transcript. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Base count for every sequence:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family: "Times New Roman","serif"'> links to a page showing for each transcript the sequence of the analysed region (as dependent on the sequence starts at filter), the assigned subclass and the number of sequenced A,C,G and T’s.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data used to generate the percentage of mutations in AID and pol eta motives plot:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Provides a file containing the values used to generate the percentage of mutations in AID and pol eta motives plot in the SHM overview tab.</span></p> <p class=MsoNormalCxSpFirst style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>The data used to generate the relative mutation patterns plot:</span></u><span lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'> Provides a download with the data used to generate the relative mutation patterns plot in the SHM overview tab.</span></p> <p class=MsoNormalCxSpLast style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>The data used to generate the absolute mutation patterns plot:</span></u><span lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'> Provides a download with the data used to generate the absolute mutation patterns plot in the SHM overview tab. </span></p> <p class=MsoNoSpacing style='text-align:justify'><b><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>SHM Frequency</span></b></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data generate the frequency scatter plot:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Allows downloading the data used to generate the frequency scatter plot in the SHM frequency tab. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data used to generate the frequency by class plot:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Allows downloading the data used to generate frequency by class plot included in the SHM frequency tab. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for frequency by subclass:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Provides information of the number and percentage of sequences that have 0%, 0-2%, 2-5%, 5-10%, 10-15%, 15-20%, >20% SHM. Information is provided for each subclass.</span></p> <p class=MsoNoSpacing style='text-align:justify'><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> </span></p> <p class=MsoNoSpacing style='text-align:justify'><b><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Transition Tables</span></b></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'all' transition plot:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGA' transition plot:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGA sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGA1' transition plot:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGA1 sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGA2' transition plot:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGA2 sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGG' transition plot :</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGG sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGG1' transition plot:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGG1 sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGG2' transition plot:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGG2 sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGG3' transition plot:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGG3 sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGG4' transition plot:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGG4 sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGM' transition plot :</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGM sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the 'IGE' transition plot:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Contains the information used to generate the transition table for all IGE sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><b><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Antigen selection</span></b></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>AA mutation data per sequence ID:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family: "Times New Roman","serif"'> Provides for each transcript information on whether there is replacement mutation at each amino acid location (as defined by IMGT). For all amino acids outside of the analysed region the value 0 is given.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Presence of AA per sequence ID:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family: "Times New Roman","serif"'> Provides for each transcript information on which amino acid location (as defined by IMGT) is present. </span><span lang=NL style='font-size:12.0pt;font-family:"Times New Roman","serif"'>0 is absent, 1 is present. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data used to generate the aa mutation frequency plot:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Provides the data used to generate the aa mutation frequency plot for all sequences in the antigen selection tab.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data used to generate the aa mutation frequency plot for IGA:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Provides the data used to generate the aa mutation frequency plot for all IGA sequences in the antigen selection tab.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data used to generate the aa mutation frequency plot for IGG:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Provides the data used to generate the aa mutation frequency plot for all IGG sequences in the antigen selection tab.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data used to generate the aa mutation frequency plot for IGM:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Provides the data used to generate the aa mutation frequency plot for all IGM sequences in the antigen selection tab.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data used to generate the aa mutation frequency plot for IGE:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Provides the data used to generate the aa mutation frequency plot for all IGE sequences in the antigen selection tab.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline PDF (</span></u><span lang=EN-GB><a href="http://selection.med.yale.edu/baseline/"><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>http://selection.med.yale.edu/baseline/</span></a></span><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>):</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> PDF containing the </span><span lang=EN-GB style='font-size:12.0pt;font-family: "Times New Roman","serif"'>Antigen selection (BASELINe) graph for all sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline data:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Table output of the BASELINe analysis. Calculation of antigen selection as performed by BASELINe are shown for each individual sequence and the sum of all sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline IGA PDF:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> PDF containing the </span><span lang=EN-GB style='font-size:12.0pt;font-family: "Times New Roman","serif"'>Antigen selection (BASELINe) graph for all sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline IGA data:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Table output of the BASELINe analysis. Calculation of antigen selection as performed by BASELINe are shown for each individual IGA sequence and the sum of all IGA sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline IGG PDF:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> PDF containing the </span><span lang=EN-GB style='font-size:12.0pt;font-family: "Times New Roman","serif"'>Antigen selection (BASELINe) graph for all IGG sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline IGG data:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Table output of the BASELINe analysis. Calculation of antigen selection as performed by BASELINe are shown for each individual IGG sequence and the sum of all IGG sequences. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline IGM PDF:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> PDF containing the </span><span lang=EN-GB style='font-size:12.0pt;font-family: "Times New Roman","serif"'>Antigen selection (BASELINe) graph for all IGM sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline IGM data:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Table output of the BASELINe analysis. Calculation of antigen selection as performed by BASELINe are shown for each individual IGM sequence and the sum of all IGM sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline IGE PDF:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> PDF containing the </span><span lang=EN-GB style='font-size:12.0pt;font-family: "Times New Roman","serif"'>Antigen selection (BASELINe) graph for all IGE sequences.</span><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Baseline IGE data:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Table output of the BASELINe analysis. Calculation of antigen selection as performed by BASELINe are shown for each individual IGE sequence and the sum of all IGE sequences.</span></p> <p class=MsoNoSpacing style='text-align:justify'><b><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>CSR</span></b></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the </span></u><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>IGA subclass distribution plot :</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> </span><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Data used for the generation of the </span><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'>IGA subclass distribution plot provided in the CSR tab. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The data for the </span></u><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>IGA subclass distribution plot :</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Data used for the generation of the </span><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>IGG subclass distribution plot provided in the CSR tab. </span></p> <p class=MsoNoSpacing style='text-align:justify'><b><span lang=NL style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Clonal relation</span></b></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Sequence overlap between subclasses:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Link to the overlap table as provided under the clonality overlap tab. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB file with defined clones and subclass annotation:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a table with the calculation of clonal relation between all sequences. For each individual transcript the results of the clonal assignment as provided by Change-O are provided. Sequences with the same number in the CLONE column are considered clonally related. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB defined clones summary file:</span></u><span lang=EN-GB style='font-size:12.0pt; font-family:"Times New Roman","serif"'> Gives a summary of the total number of clones in all sequences and their clone size. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB file with defined clones of IGA:</span></u><span lang=EN-GB style='font-size: 12.0pt;font-family:"Times New Roman","serif"'> Downloads a table with the calculation of clonal relation between all IGA sequences. For each individual transcript the results of the clonal assignment as provided by Change-O are provided. Sequences with the same number in the CLONE column are considered clonally related. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB defined clones summary file of IGA:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Gives a summary of the total number of clones in all IGA sequences and their clone size.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB file with defined clones of IGG:</span></u><span lang=EN-GB style='font-size: 12.0pt;font-family:"Times New Roman","serif"'> Downloads a table with the calculation of clonal relation between all IGG sequences. For each individual transcript the results of the clonal assignment as provided by Change-O are provided. Sequences with the same number in the CLONE column are considered clonally related. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB defined clones summary file of IGG:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Gives a summary of the total number of clones in all IGG sequences and their clone size.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB file with defined clones of IGM:</span></u><span lang=EN-GB style='font-size: 12.0pt;font-family:"Times New Roman","serif"'> Downloads a table with the calculation of clonal relation between all IGM sequences. For each individual transcript the results of the clonal assignment as provided by Change-O are provided. Sequences with the same number in the CLONE column are considered clonally related. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB defined clones summary file of IGM:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Gives a summary of the total number of clones in all IGM sequences and their clone size.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB file with defined clones of IGE:</span></u><span lang=EN-GB style='font-size: 12.0pt;font-family:"Times New Roman","serif"'> Downloads a table with the calculation of clonal relation between all IGE sequences. For each individual transcript the results of the clonal assignment as provided by Change-O are provided. Sequences with the same number in the CLONE column are considered clonally related. </span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>The Change-O DB defined clones summary file of IGE:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Gives a summary of the total number of clones in all IGE sequences and their clone size.</span></p> <p class=MsoNoSpacing style='text-align:justify'><b><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Filtered IMGT output files</span></b></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGA sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGA sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGA1 sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGA1 sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGA2 sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGA2 sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGG sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGG sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGG1 sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGG1 sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGG2 sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGG2 sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGG3 sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGG3 sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGG4 sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGG4 sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGM sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGM sequences that have passed the chosen filter settings.</span></p> <p class=MsoNoSpacing style='text-align:justify'><u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An IMGT archive with just the matched and filtered IGE sequences:</span></u><span lang=EN-GB style='font-size:12.0pt;font-family:"Times New Roman","serif"'> Downloads a .txz file with the same format as downloaded IMGT files that contains all IGE sequences that have passed the chosen filter settings.</span></p> </div> </body> </html>