Mercurial > repos > earlhaminst > t_coffee_to_cigar
view test-data/input.fasta @ 0:304d1a82708f draft default tip
planemo upload for repository https://github.com/TGAC/earlham-galaxytools/tree/master/tools/t_coffee_to_cigar commit e24b91d3051c422ee2a20caf8bb12f0896e2c84a-dirty
| author | earlhaminst |
|---|---|
| date | Fri, 11 Nov 2016 06:57:26 -0500 |
| parents | |
| children |
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MSKYWWGDEDL---------------KKHMHWFSWWKMCVP-------KE K-----GGMGFRDLHCFNLAL-LAKQCWRLLCEPESLCARALKAKYFPNG DLLNSFDRDT-----GIGGTGAVLRDEAGF--FVAASCS----------- --DIPF--VEDAATAEA-RGLRDDLLLANE-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------VGCNK-IYVEADCL-ET-MA-- ---TG-NCTAKA-DD---FS----KHIDGQ----LLRVNALLVASTIMIG VMVGMG-------AYGQRYRHHPLTGFLFLGANIVFLPL--LSYVVST-- -----IG-NED-PV--AL------YS--SD----LDIITGRCDPQ-DHII SVLMWASLVQIAAVNTTAVVAG--DDDKKG---RNI-GPPATVLLIQAIW TSYLTIDFLGKGYY-----------SM---------Q-KWSLKA--VAP- -EDVLILLPPFALTV----AK--LLIKYYAWYSARG-------------- SLAFGRNSHLIVGYMEQLKDESPH---------------AE-LA--LPPL --IVT---GEDTTL--VQK-E-PHGYSLKWLSNQADRTR--IDNNGLVTI DKVW-RLEDDIF-LKSSVKQL----KDLCFSFALFK-LLRCRFASHTI-- -AETSFIKAHNLLPHVLLQ-D--GDDERA-----IEVIADELCFLHDYYY SSLPTSY------SRSWLPILS-IS-ISLLSMGWSLFYILEITFAN---- -VGY--ASWDSWEWN-----D-HRQI-HCY-MYCDTWIW----------- ------------LKYGSTYFDDAPVFLLAALVVLAEA----CFFLAT--- -I-----------------T------LEEEVTGRLLRCKCR-LLKHWEDK MNQC-SVFALHPST--TPV------AL--LRRLIPLL---Y----R--KK ----VPRA-----------VKTAI-----LK-PLRSP-SYR-PSNG-VA- SLCTSLHLQAGNNPLSASSGVKGVASTMLVVHIATSILEERSE------- ---P-H----QP--ES---AHETVATH-------LSHYCA-----YLVAY APELLPDDNQWCKSLYKAVQKEAKHAIV-VAC----RVG-VALNPEG--L TQALSAGSEVQHDLLKNGVELG-RKLLKN-GAELGKKLVELA-EGEG-E- EVAWEVLANFWSEMILYAAP-S-DNV--DA-HA---EAVARGGE--L--I --TL------------IWALLTHL---------G-V-------------- -------------V--SRPEAAPGMP------N-----APSD-------- -------------------------------------------------- -------------------------V--- >72 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--GATGSDQVVAVEFDTFRDEW-D---PS----------DH-HI--GVDL NNISS-S-GNYTTL--PNDSF-V-GQVMSARI---------DYNSGTGQL DVMLH-NGS--------SD--G-ATHDLSVNVDLRSFLPEKVIVGFSA-- -ATNSERVALHYVLSWSFSS---SLPLVSNSSPK--SQA---------RR TAVPLVA------GVTVATVLA-LL-LST-AVGVLLWRSRRQERSA---- -DD--ED------------DDHDPW--AID-EDLESGSGPR---PFQLS- ------KLTAATRNFSEETKLGQGASGSVYRGRVDEL-----DVAIK--- -VFSRGGSAQGKREYTAE-VTVISRLRHRNLVHLIGWCDGREKLLLVYEL VPNG-SLDRHLYSA--AAV--LPWPAR--YKIILGLG---AAVLYL--HE -E--WGQP-----------PRPPDDR------------------------ -------------------------------------------------- -------------------------------------------------- ---SICRLVEWAWGMYGRG-----AVLDA-ADEALCGQLDAREVELV--L VIGLWC--AHP-------------------DARARPSIREAV-EVLRSG- MAARVPALPPRMPVAMYVQP-DHP-T--EKFVA---DDASKANS--RMSS HDYG------------RQPPAA--DDYQTLSTTS-S-------------- -------------IP-P-VGSKQSV------------------------- --------------R--------------LLSGR---------------- ----------------------------- >78 MPTI---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---YK-YCPRKLLRY---FTEKVGERLRGQ----IFRVNALMVVMGILMG FMVGIG-------TYGHRYRHIPLIRFLFLAATTLFLPI--VSYIVSS-- -----SD-LDNYKS--TT------IL--------IETTVVYCRAR-AHIM FVLIWTALVLNVGINTTALVAA--DA-REG---RSI--PPNMTLLIQAMW TSYLGVYICIVSGP---------------------------------PP- -QMILFLLGPFGVIF----AK--LVLKCYAWYIATQ-------------- SLAFGRNARLIVGYMEQLAS--------------------E-H---MPPL --IVT---GEHTMQ--IQE-K-PCGYQLKSMSYRL-RDD--MYNKGLVTF DKVW-QLNDTLL--RSKSPQL----KELCFSFALFK-LLRCRIARFNI-- -FWK----------YILA-------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------ALVILAEV----RDIAFY--- -IRSNWIKVALICQYVK-HGSWRQSATIQRCVGCVLRSKGK-LIRNWEDK MGQS-SVLVLHPSK--TPM------AL--LRHLIPLS---G----Q--NT -K--TPSA-----------VKSAI-----VG-ALRKGYER-GQINGDVP- SFQRILHLQDDDEIIWTFGE-R-----------------ARLP------- ---THQ----PP-SDT---DHISAANH-------ISQYCA-----YLVAH YPELLPEDDEWCKSLYKAVEKDAKRVLI-G-N----DSMSEVEYRRR--L IQLLSA--ERN----------H-E-VLKD-GARLAEQLAE----E-G-E- EVAWKALAAFWSDMILYVAP-S-DNI--DG-HM---EAIARGGE--L--I --TL------------LWALVTHL---------G-I-------------- -------------V--GRSDNTTDA-------------ATVD-------- -------------------------------------------------- -------------------------V--- >74 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------MDNFFNSVFSAAAA--GEHEEE-EG EEEEREG-EQA-AERD----------GGGDS--G----GGWSFGGLMKTL AEEIEGQ------------------------------------------- -------------------------------------------------- ---------------------REEQDG----------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------GG---- -------------------------------------------------- ----------------QGGLL------S--HANEALRSVDADGEDA---- -T--GD------------GS-SQLSE--SA-SGASWRSSLP---SKKYTR FEAQVLALRADPTTFTEEPEDAEGL--SRWQEAFSVQE--RKDEIEG--- -VLRESPGLES----------FVERLVPSVVAYDMFWCRYF---FAVD-K LRQAEDVRTKLVSR---------------AMSKEDEE---ELSWEV--DD ----DE------------DDIQGDHKQGTVT-IPDKKE-EHIGES----- VSHEAQVEGKQE-------------------------------------- -------------------------------------------------- ------------VAVNEKYAAEDKEMIL-VAPKDNNGESSGEASTPKLSN G---TG--QEV-----------KTEA-GDSCKESDLSLVSR-PSVQE-E- DLSWEEIEDV----------------------------GDQDEKKAG--S --PR------------SSPSSK--VEDIRKRLNS---------------- -------------V--EDDEDLSW---------------DV--------- --------------------------------DE---------------- ----------------------------- >66 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------MG-- ---AG-NCSGQAISD---FS----KHIDGQ----LMRVNALLVASTIVIG VMVGIG-------AYGQRYRHHPLTSFFFLGASTLFLPI--LSYVVST-- -----IS-GNQ-GP--VA------VL--SD----TQIITAWCNTW-KHIT LVLVWASLVQIAAVNTSAIVAG--DD-KKG---RNIASPPAMVLLVQAIW TSYLVVNFIGKAYD-----------A-----------------D--FGN- -VFIPILVPPFAVLV----AK--LLVKYHAWYGARG-------------- SLAFGRNPNLIVGYMEQLKAELAS---------------EQ-HS--LPPL --IVT---GEDTTL--VHK-E-PHGYSLNQA----NGTG--IDNNGLVTI DRVW-QLEDDIF-LTCSTKQL----KDLCYSFALFK-LLRCRFARHTI-- -AETGSMKAHTLLPHVLLQ-V--NDDERA-----LGVIADELSFLHDYYY SSLPALY------SRSWFPILS-IF-ISLLSMGWSLFCILATTFVI---- -VML--ASK---GG--------AGQM-HCS-IDCHPMYDKN--------- --------------YGSLFFDFAPVFLLAALVVLAEV----RETACY--- -ICSNWTKVSLICRYVRHASSWQQSPWKKKLIGRLLRCQCK-LLKHWEDK MNQC-SVLALNRRT--TPV------AL--LHRLIPLL---D----R--KK ----VPRA-----------VKIAV-----LK-PLRSP-SWKNRSNG-VA- SLCTRLQLQANNNPFSASSGVKAIADTMLVAHIATSILEVRRS------- --EPPR----QA--DS---AHKIAATH-------LSRYCA-----YLVAY VPELLPDDDEWCKSLYKAVQKKGKRALG-AAG----GARAAASNPEA--L VQALNARPETAHY------------VLKN-GAELGKKLVELA-AEEG-E- EAAWEVLADFWSEMILYAAP-S-DNV--DA-HA---EAIARGGE--L--I --TL------------LWALLTHL---------G-V-------------- -------------V--SRPEPA--TP-----DD-----APGD-------- -------------------------------------------------- -------------------------V--- >82 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAS------- ------------------------------------------------R- --------------------QSLLPSFLYA-----AS------------- -------------------------------------------------- -----------SGAAM------P-DG--R--------------------- -------------------------------------------------- -GA-----P----VVARAPS--EPPFGKIDMFSPAYY------------A ACGFGGAA---------------A---CG----------LT--------- ---------HAAVT--PLD-V-IKCNIQIDPA---------KYKSISSSF SIVLK-EQG---------V----RGF-------FRGWAP--TFLGYSA-- -QGAFKYGLYEVFKKEYTDM---AGPEYAAK------------------Y KTLIYLA------GSATAEVVA-DVALCP-MEAVKVRVQTQPGYAR---- -G-----L--------RDGF-PKIVR--AE-GYAGLFRGMV---PLWGR- ------QIPYTMMKFATYENIVE----MAYRHLIPTP----KEQCSK--- -PLQLG-------------------------------------------- -----------------------------------VS---FGSGYI--AG -V--FCAA-----------ISH----PAD--------------------- ---------------------------------------NLVSF------ ---------------L---N-------N-------AKGAT-----VG--- ---DAVKNL-GLWG-----------------------LFTRGLPLRI--V MIGTLT-------------------------------------------- -----------------------------G-------------------- ---T------------QWVIYDSFKVMAGLPTTG-G-------------- --------------A-------PAA------------------------- ----------------------------APREEA---------------- ----------------------------- >57 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------MEG- W-----DCDSASES----FS----KHVSGQ----MLRVNALLVVNAILMG VMVGTG-------AYGHRYRHHPLTRYIFLGATALFIPI--ISYVLSA-- -----IG-NQN-GI--IL------FA--AG----E-IIIGQCDPS-RHMN LVLLWTGLVQMVGISTTLVVVS--DP-REG---RNI--GPSGVLLVQAMW TSYLVIYNIGLNYDVS---SYNNTRSY---------L-KWSLVY--AFS- -LEGLKVIPPFALTF----AK--LLFKCFAWYKARK-------------- SLAIGCNPRLIVGYMEELQDTDMT----N-----S----YW-DI--PPPL --I------------------------LCLMP----------NIGGLVTI DKVW-QLDDMHD--LKLTSRL----KDVCLSFALSK-LLRCRFTRYTN-- -DEIGFTKASNFLRHMLLG-D--SYDDRL-----LRLVEHELSFLHDIYY SSLAISY------SKIWMPLLS-IL-ISLSGIGYCLVLSILIVYVQ---- -IDY-LNDT---SDG-----Q-LPLI-RCN-YQCRRFISEV---QGKIP- ------A--VHRQFFGSAIFDLVPVVVLIALVVLAEI----REVASY--- -ICSNWTKVTLICHYINH-ASWQKSHMMKKCIRRVLQCRCK-ILKHFEDK RNQC-SILVLHQTK--TPM------RL--LHLLK--P---G----Q--KV -K--VPRE-----------VKAAI-----MN-ALRSY-EGSRDNNR-IP- CLITRPQFKTGDNLLWVVDGTKGIANTILVCHIATSILELRSA------- ---GSC----QP--LT---DHKTAAIH-------MSRYC----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------A--- >68 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------MA--PSP- -------------------------------------------------- -------------------------------------------------- --------------G----------------------------------- -------------------------------------------------- ---------------------------------APWCHALPTWQVTADSR FEAQLRALQSDPATFTADPEDAEDF--AAWGAGFSLQE--RQDEIEA--- -LRYESDAVEG----------MVDRLVPDAVDGEVFWARYF---YRVH-K LKQQEDARAKLVKR---------------VIAQEEEE---DLSWEV--DD ----EVEEEEPAKEEAIKQAPIKEEPKPEVQERENEKL-EAEGRV----- NAVEEAGALDKE-------------------------WKKAD-------- -------------------------------------------------S ---PQPDVFGSSMVVVDKEEKEDASKLN-VEESSDKKTAAEEPHSTTGDA A---VK--EGT-----------KHET-SDSSKDSDYSMVSRQRTATE-E- DLEWDEIEDL----------------------------GEHEE-KKG--S --AH------------GSSSAP--KEELRKRLSV---------------- -------------A--EDDEDLSW---------------DI--------- --------------------------------ED---------------- -----------------------DDDDKA >84 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAELKLCL-- -------------------------------------------------- ---CFL-------LLCVHVHHATAISFSYN-----SFRS--GDFREE-DD A--M-VT-DGR-IE--LV----------GDE--A----GGRARGRVLYKQ AVQLWDGVKGETASFTTSFNFSI-QS-LPG---RSS-------------- -------------------------------------------T--PGH- -GMTFFVAPY----MPEMPQE--SYDGCLGLFDEKHAPK---NGT--TII SANASGSASFVAVEFDTHRDAW-D---PS----------SR-HI--GVDV NNVDS-R-GNFRIL--PEGSL-VDAGVMSSTV---------TYDNATSWL DVVLR-VSG--------------AKYALGATVDLRSLLPEQVALGFSA-- -ATGDAFGSSHTLLSWSFHS---TLPTRNYTA-LPSTSS--------TKK ATLPLIA------GVAAAAVVA-LL-LAV-TVAVLLRRASRRNRQT---- -DD--KDM------LAGDMTPDSLD--ADG-DELGSSTGPR---PIPYA- ------SLAAAARNFAEGGKLGQGGSGA--RGTSRRK------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------GSWGR----------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------A---------------- -------------DPGR-CTG----------------------------- --------------------------------AT---------------- ----------------------------- >86 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------MAQG- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------EARE--- -FLVVG-----------------------------------ASYLDIVDV CGNE-TV------------------GR--YQIILGLA---SAVLYL--HQ -E--WDQC-----------VVHGDIKPSNIM-LDESF-NT----KL-GDF GLSRLIDHGMSLQTMTAMAGTPGYLDPECVITGKASTESDMYSF------ ----GV----TLLEIV---CGRRPMAP-P------SAGAR-----AG--- ---RVFRLLEWVWDLYGRG-----AALDA-ADERLGGVFDRWEMERV--V AVGLWS--AHP-------------------NPKMRPAMRQAA-EALQS-- RKFRMPVLPPKMPVAVYLQP-FGDSA--MEY-G---DSTTTVGS--GVTT --QL------------QYSSTS--CTTATQSSNT-S-------------- -------------MP-A-AAS---S---------------RE-------- ----------LGAYELVYVHAIVLQSKNRDAEKT---------------- ----------------------------- >31 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------MDHLPLCS--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------NATLER-CW---CQL-------- ---HP-NCSDNLVAR---LH----KRLKEE----IWQVDVLLFISAIFAG VIVGIG-------AYGHRHRYHALARHLYLGATTLVLPI--ISVLLSA-- -----DS-STR-TY--FNITLER-HI--FP----QETLTAQCSTNDHHLY MVILCACLVPLSAINTSSIVAG--DY-REA---RDI--APPFELLVWGIW IFYLVVTNNVFDEW--------------------------LPNN------ -FFFYFQYTPFAIIY----TK--MAYKYYAFERAMR-------------- SLALGHNPRLIVGYMRQLREAPP-A-D-----------QDH---HVPPPL --IVM---GEEGLRQVVDA-EHRRGHLVFNS------DR--AGNGCLVTI DR--------------------------------------------KS-- -ADTYSMETLNTLRSVLLK-D-----EST-----FVVIADELSFLRDYYY SSHPISY------SACWLPVLS-IS-ISLFSIGFCMLVGVAIN------- -KC--YGEA---DEY-----G--YQI-TCISWCTVGYLKTA---D----- ---------SREYKLGSLYVALVPVVLLCALVMLSEA----RDIASF--- -ICSNWTKVARTCRSMS--HTSLQK---KWYVGLLLRCRCN-LLKHWNGR MSQC-SILMLHPSR--TPQLLLRL-GLL-LRCLLRLPDQK-M---K--SV -E--VSAA-----------VKVSI-----IN-TLRSS-CCNNNN----G- GLCLLIRQQVGESSLQAAFGCEGTSDTILIWHVATSILEVKHPFNQHDDD LQQQQH----SP--DS---SSRSVATH-------LSRYCT-----YLVAF CLELHPDDDAWSKGLYRDVKKDTERTLG--------SLFGLGLGYQQ--L VDKLQT--AES----------KYG-VLKD-AAKLVKELAELP--G-G-E- E---------------------------------------------T--V --GV------------AYQVLVRD---------D-L-------------- -------------V--HRALGQ---------------------------- -------------------------------------------------- -------------------------S--- >24 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------MGSTV-HGP-S-- ---AH-SKSEEFWLN---HI----TRGENNERSPTARPPNLSPDATASKS SLESPD-------PNPNPSLQARAPMDNFFNSVFAAAAA--GEEEEE--- --EREGE-EEQ-AASAAE------RDGGGDF--G----GGWSFGGLIKTF ADEMEAQRGDHEEGEQEAAAAA-VEA-EEEG--G-G-------------- ------------------------------------------SG--GGW- -SFGGLIKTL----AEELPQREEEEAVEEEEEEER--------------- ---------------------------------------EQ-ET--EAAA AEEDLGE-----GD--FSGGG-WSFGGLMKT------------------- ----------------------------------FASRSESVLEGYRRDL QDLGTGLRLETTVLRQAAVR---AAAALPGALEA-GAS---------VAS DRLESVGQAVDDLGAAAAGLL------S--HANEALRSVDAEGEEG---- -D--GD------------RS-SQPSD--SA-SGASWRSSLP---SKKYTR FEAQVLALRADPTTFTEEPEDAEGF--TRWQEAFNLDE--RKEEIDG--- -VLRESPGLES----------FVERLVPSVVAYDTFWCRYF---FAVD-K LRQAEDVRTKLVSR---------------AMSKEDEE---ELSWEV--DD ----EE------------EDSNGDRKEDADT-TVDKKE-EQIDQP----- VSHEAKGHGKQT-------------------------------------- -------------------------------------------------- ------------A-VDGEIVVEDKETPL-AARNDDSGEHNGEALIPTPSS V---TG--REE-----------KTEP-SDSSKESDLSVVSQ-PSMLE-E- DISWEEIEDV----------------------------GDQDEKKGA--S --PR------------SSSTSK--AEDIRKRLNS---------------- -------------V--EDDEELSW---------------DV--------- --------------------------------DE---------------- ----------------------------- >29 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------MSEFGNQV-DI-MS-- ---SI-ACTTDGSEL---FS----KHVNGL----LLHVDTLLVANAILMG VIVGLG-------AYRHRYRHHPLIRFIYLGATTLFLPI--VSYVTST-- -----LE-NPY-TP--IV------YV--AG----NRFVTANCYTD-DHVT LVVLWIGLVQIVGTNATAIVAS--DS-REG---RSI--APPAVQLVQAIW TSYLAYITIESGLQPSG-------Y-----------V-NWSPNGGAMHT- -HDDVFLALPYALIL----AK--LLFKYYAWYKARR-------------- SLVLGQNPRLIVGYMEQLQDGVHHA-E-L-----A----SE-HA--PPPL --IVM---KEDTIL--VEKLQ-PRGYSLTTTG----ISN--NNNNGLVTI DRVW-QLDDTLL--PRPMEQH----KDLCLSFELFK-LLRCRFARYTI-- -SEVGFMKASNFMRHGLLK-D--SDHERV-----LGVIAHELSFLHDYYY TSLPISY------SESWLPILS-VS-ISLSSIGYCLYVIIYLSVID---- -GG--Y------PG------A-DPQI-HCY-AVMRR-DPDT---YDIPS- ------TLLNNEENFGRLYPELVSVYLLVALAVLVEV----RDIASY--- -ICSNWTKVALICGH----------------------------------- ------------------------------------------------KK -K--VPRA-----------VKVGV-----VD-MMRNN-E----------- -------------LLWTFHGGKGAAEAILVCHVATSILEARRYSRLP--- --NPNQ----QP--LSGSDHNKIAATH-------LSRYCA-----YLVAC LPELLPDDDVWCKNLYTAVKKEAALVLK-LKG-KEVECCL------R--L VELLSE--QSK----------H-Q-VLKD-GAELGKRLAQ----G-A-E- EAAWKALADFWSEMVVCVAAAC-DNL--DE-HA---KAVARGGE--L--V --TQ------------LWALLLHV---------G-S-------------- -------------V--DDEDTAAATA-----HD-----APDA-------- -------------------------------------------------- -------------------------V--- >21 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAAALSCS-- -----LRCWTITG---------------------------H----HRLLR VV-V-F-------LLLSLHHQASSLNFHYD--YINTTNK--ADFGSLGDD C--N-IS-DHR-AE--LT----------SHS--DQ--NYINNLGRLVFPN AMQLWDPATGDTASFSTAFSFGI-EA-LPG---MEV-------------- -----------------------------------------------GH- -GMAFFLTGAPVGTASNVPTN--SFGGFLA----LFGPD---ILTSRGNA TGSGGDDYRIVAVEFDTVKDDW-D---PS----------AR-HI--GVDL NNISSSL-GNYMVL--PDDSL-V-GRVMSARI---------DYNGSTGRL DVVLR-NGS--------SSDDGNTTYAHSTIVDLRSVLPPQVVVGFSA-- -ATSKDRVALQYVLSWSFST---TSPVGNGTSAQPQQRR--------RHT GSTQVLV------GVTVAAVLA-LL-LGT-FVGALLWRSRRRRSDD---- -DD--ESSD---EVSSGEEDDDGSW--AME-EDLESGAGPR---PFRLR- ------KLRAATGNFSEEEKLGQGASGSVYRGRVDDL-----DVAIK--- -VFSRGGSAQGKREYTAE-VTAISRLRHRNLVHLIGWCHGRKKLLLVYEL AADE-AL--------------------------------------L--R- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------GEMGFDAREMERV--L VVGLWC--AHP-------------------DAAARPSIREAV-EALRSG- EAAKLPALPPRMPVAMYVQP-YYDPAESERYVV---YDTTTLTA--TTSV TAEY------------NYRTSS--RDYSTLYSTS-G-------------- -------------IP-P-VGSKQSV------------------------- --------------R--------------LLRGR---------------- ----------------------------- >12 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAP------- ------------------------------------------------R- --------------------QPLLPSFLYA-----PS------------- -------------------------------------------------- -----------SSGG---------AG--F--------------------- -------------------------------------------------- -GSAQ-EAA----VVAGAPS--EPPFGKIEMFSPAYY------------A ACGFGGAA---------------A---CG----------LT--------- ---------HAAVT--PLD-V-IKCNIQIDPA---------KYKSTSSAF SVVLK-EQG---------V----RGF-------YRGWAP--TFLGYSA-- -QGAFKYGLYEVFKKEYSDM---AGPEYAAK------------------Y KTLIYLA------GSATAEVVA-DVALCP-MEAVKVRVQTQPGYAR---- -G-----L--------RDGF-PKIVR--AE-GYAGLFRGMV---PLWGR- ------QIPYTMMKFATYENIVE----MAYKHVIPTP----KDQCSK--- -PLQLG-------------------------------------------- -----------------------------------VS---FGSGYI--AG -V--FCAA-----------ISH----PAD--------------------- ---------------------------------------NLVSF------ ---------------L---N-------N-------AKGAT-----VG--- ---DAVKNL-GLWG-----------------------LFTRGLPLRI--L MIGTLT-------------------------------------------- -----------------------------G-------------------- ---T------------QWVIYDSFKVMAGLPTTG-G-------------- --------------A-------PAP------------------------- ----------------------------AAVPKE---------------- ----------------------------- >10 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAVLKLVA-- -------------------------------------------------- ---MAV-------LICVHVHHSAAVSFSYS-----SFSS--VDFREE-DD A--R-ITAAGR-IE--LL----------GDE--S----GGRARGRVVYKK PVQLWDGVTGEATNFTATFNVNI-TS-LPG---RSS-------------- ------------------------------------------SA--VGH- -GMAFFLAPY----MPDLPQE--SYDGCLGLFDESLIQPAQQNGTTAPIP SANATGGARFVAVELDTHRDAW-D---PS----------GR-HV--GVDV NSVDS-R-GNYVIL--PDASL-VDAGVMSVTV---------SYDSAMTSL DVALV-VGA------------TGATYRLAAVVDLRSLLPEQVAVGFSA-- -ATGDMFASDHAVLSCSFHS---TLATRNNNTST-SS-S--------SKK ATVLLHV------GVTAAAVLV-LL-LGL-TVGLLLRRASRRPPDN---- -E--KKDM------LAGDED-DDSL---DD-DEFGSSTGPR---SIPYA- ------QLAASTEDFAEERKLGQGGSGSVYRGHMEELDDGRRDVAIK--- -VFLRGASLEGRKEYRTE-VTVISRLRHRNLVQLIGWCHGRRRLLLVYEL VHHG-SLDRYLYGSK-QET--LTWQLR--YQIILGLA---SAVLYL--HQ -E--WDQC-----------VVHGDIKPSNIM-LDESF-NT----KL-GDF GLSRLIDHGMSLQTMTAMAGTPGYLDPECVISGKASTESDVYSF------ ----GI----TLLEIA---CGRRPMAP-P------SADG-------K--- ---QVFRLLEWVWDLYGRG-----AALDA-ADQRLGGTFDRWEMERV--V AIGLWS--AHP-------------------DPKMRPAIRQAA-EALQS-- RKFRMPVLPPRMLVAVYLQP-FGAST--MEY-GYGGDSNTTVGS--SVT- ---M------------QCSLTS--QTTATQSSNS-S-------------- -------------VP-A-GDS----------------------------- --------------------------------SQ---------------- ----------------------------- >19 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MDERSYICAL LYNILLCPVETSSQV----------------------TT-A----MAGL- -K-LYLFSSRAACFLLLCVHHATAISFNYD--N--SFSS--DDFREE-DD A--S-IT-NGR-IE--LL----------GDE--A----NARARGRVLYKQ AVQLWDGVTGEAASFTASFNFSI-QS-LPG---RSS-------------- -------------------------------------------T--PGH- -GMTFFIAHY----MPQLPQD--SYDGCLGLFDERHAPK---DGT--TAI STNASGSASFVAVEFDTHRDAW-D---PS----------SR-HI--GVDV NNVDS-R-GNFEIL--PEGSL-VDAGVMSSTV---------NYDNATARL DVDLR-VIG------------TGARYTLSATVDLRSLLPEQVAVGFSA-- -ATGDAFFSYHTILSCSFKS---TLPTRNDAP-FPSTSS--------TKK ATLQLSA------GVGAAAVLV-LL-LAV-TVAVLLRRASRRNRQE---- -PEVDKDM-----LAGDMTP-DSLDA-AAD-DEFGSSTGPR---PIPYA- ------NLAAATGNFAEEGKLGQGGSGSVYRGHMKEVG--GRDVAIK--- -VFLRGASLEGRKEYRSE-VTIISRLRHRNLVQLIGWCHGRRRLLLVYEL VRNG-SLDGYLYSK-DDLI--LTWQLR--YQIIVGLA---SAVLYL--HQ -E--WDQC-----------VVHGDIKPSNIM-LDESF-NT----KL-GDF GLSRLIDHGMSLQTMTAMAGTPGYLDPECVITGKASTESDMYSF------ ----GV----TLLEIV---CGRRPMAP-P------TGGAR-----DG--- ---QVFRLLEWVWELYGRG-----AALDA-VDERLGGVFDRWEMERV--V AVGLWS--AHP-------------------NPKMRPAIRQAA-EALQS-- RKFRMPVLPPKMPVAVYLQP-FGDST--MEY-G---DSTTTVGS--GFT- --TQ------------HYSSTS--RTTATQSSDTTS-------------- -------------MP-A-TVS---E------------------------- --------------E--------------LNSNI---------------- ----------------------------- >39 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAS------- ------------------------------------------------R- --------------------QSMLPSFLYT-----SS------------- -------------------------------------------------- -----------SGAGM------P-GG--W--------------------- -------------------------------------------------- -GAAQ-EAPV---VVAGAPS--EPPFGKIDMFSPAYY------------A ACGFGGAA---------------A---CG----------LT--------- ---------HAAVT--PLD-V-IKCNIQIDPA---------KYKSISSSF SIVLK-EQG---------V----RGF-------FRGWAP--TFLGYSA-- -QGAFKYGLYEVFKKEYTDM---AGPEYAAK------------------Y KTLIYLA------GSATAEVVA-DVALCP-MEAVKVRVQTQPGYAR---- -G-----L--------RDGF-PKIVR--AE-GYAGLFRGMV---PLWGR- ------QIPYTMMKFATYENIVE----MAYKHLIPTP----KEQCSK--- -PLQLG-------------------------------------------- -----------------------------------VS---FGSGYI--AG -V--FCAA-----------ISH----PAD--------------------- ---------------------------------------NLVSF------ ---------------L---N-------N-------AKGAT-----VG--- ---DAVKNL-GLLG-----------------------LFTRGLPLRI--V MIGTLT-------------------------------------------- -----------------------------G-------------------- ---T------------QWVIYDSFKVMVGLPTTG-G-------------- --------------T-------PAA------------------------- ----------------------------APREEA---------------- ----------------------------- >33 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----M--LTLQHSIIG-RMVVFFLRVCQH-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------LQLVL-MFEFDMCVKQI-MG-- ---VG-NCSDQAITD---FS----KHIDGQ----LMRVNALLVASTIVIG VIVGIG-------AYGQRYRHHPLTSFLFLGATTLFVPI--LSYVVST-- -----VD-SNL-GV--VT------IS--SD----AHIIPGWCSTR-SHIY TVFVWASLVQIAGANTTTIVAG--DD-NKG---RNI-TLPGTVLLVQAIW TSYIVVYYLGGGYY-----------ST---------R-QWSIKH--MDL- -ANGLPVLPLFSLLI----AK--LLLKYYAWYGASR-------------- SLAFGRNPHFIVGYMEQLKAKLTS----------------E-HS--LPPL --IVT---GEDTTL--VQK-E-PHGYSIKWLFNQADGTG--IDNNNLVTT DKVW-RLEDDIF-PRYSTKQL----KDICFSFALFK-LLRCRFTRHTI-- -AEFGFIKAHNLLSHVLLQ-D--VDDERP-----LGMIAHELSFLHDYYY SSLPTSY------SSSWLPILS-IS-ISLLTMGLSLLYLLLITVVI---- -LLY--AFM---GWP-----H-HGQM-QCF-LNFHPSFQNE---HEDFF- ------YSSSNQIQYGNIFFDLAPVGLLAALVVLSEV----REIACY--- -ICSNWTKVFLICSYVRHASSWQKSHWKKKMLSLVLRRKCK-LLNHWVDK MNQC-SVLALHPST--TPV------PL--LGRLIPLL---H----R--KK ----VPRA-----------VKAAL-----LK-PLRSP-NWKNRSNG-VA- SLCTRLQLQADNNPLSTSNGVKGVADTMLVAHIATSILEVRTS------- --EPLR----QA--DS---ANEIAATH-------LSRYCA-----YLVAY VPDLLPDNNEWCKSLYKGIKKKAKRALA-ASG----NTGQASLSPEA--L VQALSAGSEEAHD------------LLKN-GAELGKKLVELA-GNEG-E- EVAWELLAEFWSEMILYAAP-S-DNV--AA-HA---EAIARGGE--L--I --TL------------LWALLTHL---------G-F-------------- -------------I--SRPEAA--MP------N-----TPGD-------- -------------------------------------------------- -------------------------V--- >53 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MLLAPALL-- -----LCRSQSSSEL---------------------RAT-A----MAVL- ---KLC-------LCLMLVHHAAAV----------SFSP--GDFRAE-DD A--R-IT-DGR-ID--LL----------GDKNFP----GCRARGRVLYKQ PVQLWDA-TGEAASFTASFNFTI-QS-LDG---GKG-------------- -------------------------------------------G--PGH- -GMAFFLAPY----MPEMPQE--SYEGCLGLFDETAN------------- MASASGSARFVAVEFDTHRDPW-D---PS----------SR-HI--GVDV NSIDS-R-GNFLIL--PDDSL-VDAGVMSSTV---------KYDNSTTRL DVVLS-VGD--------------TTYNLSATIDLRSLLPDQVSIGFSA-- -ATGAAFGSNHTVLSCSFQS---TLPTVTTS--T--PL---------PST WSTKLIA------GVAAAAVLV-LL-LGV-TVAVLLRRASRRNGQP---- -D--DKDM-----MLAGDMT-PDSLD-MDD-DEFGSSAGPR---PIPYA- ------NLAAATRNFAEEGKLGQGGSGSVYRGHMKELG--GRDVAIK--- -VFSRGASSEGRKEYRSE-VTIISRLRHRNLVQLIGWCHCRRRLLLVYEL VHNG-SLDGYLYSKSKEEV--LTWQVR--YQITLGLA---SAVLYL--HQ -E--WDQC-----------VVHGDIKPSNIM-LDESF-NT----KL-GDF GLSRLIDHGMSLQTMTGMAGTPGYLDPECVITGKASTESDMYSF------ ----GV----TLLEIV---CGRRPMAP-P------RDGAK-----DG--- ---QVFRLLEWAWDLYGRG-----AALDA-ADEHLGGVFDRWEVERV--V AVGLWA--AHP-------------------DPKMRPAIRQAV-EALQS-- RKFRMPVLPPKMPVAVYIQP-FAAST--MEY-S---DTTTTVGS--S--- --------------------NS--RTTATQSSNT-S-------------- -------------MP-A-AVS---E------------------------- --------------E-----------------LV---------------- ----------------------------- >58 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------MDNFFNSVFSAAAA--GEHEEE-E- -GEEEER-EGE-AAER---------DGGGDS--G----GGWSFGGLMKTL AEEIEGQREEQEEGGQGGKAAA--EE-VQGEEAG-G-------------- ------------------------------------------SG--GGW- -SFAGLIKTL----AEDLPQRDEQEAAEDEDDE----------------- ----------------------------------------R-EA--EAPE EEEVG-E-----DG--VSGGG-WSFGGLVKT------------------- ----------------------------------FTSRSESVLEGYRRDL QDLGSGLRVETTALRAAAAR---AAAALPGALEA-GAS---------VAS DRLESVGQAVDDLGAAAAGLL------S--HANEALRSVDADGEDG---- -T--GD------------GS-SQLSE--SA-SGASWRSSLP---SKKYTR FEAQVLALRADPTTFTEEPEDVEGF--SRWQETFSVEE--RKDEIEG--- -VLRESPGLES----------FVERLVPSVVAYDMFWCRYF---FAVD-K LRQAEDVRTKLVSR---------------AMSKEDEE---ELSWEV--DD ----DE------------DDNQGDHKQGTVT-IPEKKE-EQIDDS----- VSHEAEVEGKQE-------------------------------------- -------------------------------------------------- ------------V-VNEKCAAEDQAMIF-AATKDDNGESSGEASPPKSSN G---IG--QEE-----------NTEA-GDLCKESDLSLMSR-PSVQE-E- DLSWEEIEDV----------------------------DDQGEKKGG--S --PW------------SSPSSK--VEDIRKRFNS---------------- -------------V--EDDEDLSW---------------DV--------- --------------------------------DE---------------- ----------------------------- >2 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------MNFFSSVLSAAGV--GGDEHE-E- ---ERGE-GEE-AAAEQG------EEGEAES--G----GGWSFGGLIKTL AEEIDVRPRDEQEAEEGGEEVAEGKG-EVEEEA--D-------------- ------------------------------------------AG--GGW- -IFGGLIKTL----AEEIEEQRKVNSQLEAEEEAA--------------- ---------------------------------------AA-AA--AAAA AAAEEEG-GETAGS--GDGGE-WSFGGLIQT------------------- ----------------------------------FATRSESVLEGYRRDI QDLGSGLRLETATLRAAAAR---AAAAFPGALEA-GAS---------AAS NRLESVGQAVDDLGAAAAVLL------S--HANEALRSVDADGEDG---- -A--GD------------GS-SHPSDSASA-SGASWRASLP---SKKYTR FEAQVLALRADPATFTEEPEDADGF--AKWRDAFRIDE--RKEEIEG--- -VLKESPGLES----------FVERLVPSVVDYDMFWCRYF---FAVD-K LRQAEDVRTKLVTR---------------AMSKEDEE---ELSWDV--DD ----DDE-----------DDDNGDHKEGANT-VVNKKE-EQIEEP----- VSHKTEDD-KQ--------------------------------------- -------------------------------------------------- ------------G-ADTPDVSEDKKTTL-AAEKDGNGESKDEVAAPKSSN D---MG--REE-----------KI----DSSKESEFSAASP-PSAQE-E- DLSWEEIEDV----------------------------GDEDEKKKP--I --PR------------SSPPSK--AEDIRKRFSS---------------- -------------V--EDDEELSW---------------DI--------- --------------------------------DE---------------- ----------------------------- >4 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------MSMS-GP----- ---RE-ACDVTGLDE---FY----KRMQAR----VWRTRGQLIFAAAVVT ILVGSG-------VYSRRHRRHGFARFVFLGASTLYLPV--VSYLVSD-- -----IG-GEN-CG--LP-------K-----------DVKECK-D-MSAF FLEAWAILALIFGANSFVIAAA--DD-HGG---QNV-HRPVAELLVRAIW TSYISVHHFRIIF--P---------------------------------- -LDRVFISMSCGFVL----VR--IVVKLYAFLKAQR-------------- SFAHGRNPRLIAGYMDQLKQDIMSS-S-SSSHHAQ----AV-NV--ALPL --LVM---GEDEQQ--VEEG--PHGYRFRDRK----------GNESLVTI GKVQ-IMSST-DGVLSSWPPL----KDLCLSFSLFK-LLRRRFARCVV-- -VEEGSEIGPNMVCTLFDSD---TEPERI-----VSIVADELSFACDFYH SSLPVSC------SVFWLFVLN-IL-FSFAGTACCLFIAIRTIQHVVSVA QVG--P-MS---SDP-----F-YHQI-TCV--LIC--GKN---------- -------DQAKQ--FGSILFFMVLSFLFVIVLIFDEV----WEIVSY--- -MCSNWTKVTLICYYITK-PTWQQSPRMRRLIRCVLQFRCNLLG-YWSDK MGQT-SLMDTNMNI--GPI------V--RIKQLLGLP---V----QTKQV -K--IPTE-----------VKAAI-----IN-TLKSQ-NW----RP-TD- CITSLQQSHIGKSFSWACKGD-GTSDVILVWHIATCIFEIRHS------- --TEPL----IA--DS-I-SNKITATY-------LSQYCA-----YLLSS ASELLPDDKAWSKKSYESVKKIVDPIFS--------GRNDKPLEYEY--I LLLLVE--KSR----------SDM-ILNK-GLTLGKQLVEGI--E-D-E- EMGWTVLAGFWSEMILYIAP-S-DNI--DA-HR---RAIARGEC--S--Y --SIPTTTPKKIDVRFIVVVISYA---------T-LLVIDVRFIVLAVFP FIALAFIAALCVAL--IRAEADNGGE-----PGASSSSASSAAATDREGN KNTTTTAAEEAEQLTAMSVVPYWALCVTGHGPRHGPRRHPVSPLPQRHTG RAGPDADEAQLAVRRRRGSGRRAGVA--- >6 -------------------------------------------------- ---------------------------MAGLGMLVE-------------- --ALRD-------------------------------------------- ----------------NFGAFIGS-LVDF--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------WSDCHNKVARSIKAI-MS----- ---ST-TCGFRS-ND---LI----ERINKD----VLTTNALFVANAFLVV ILVGAG-------SYGRRYRHIALNRYLFLGASTLVLPI--LSYVVSY-- -----VG-RDK-YY--NL-------F-----------HGLECV-D-NRAF CLLLWAALLPMVGMNTSSILTA--VH-NGN---E-E--LP---------- -------------------------------------------------- ---DIIISTLLGLGF----IK--IILKFVAYGRARR-------------- SFAMGQNPSLIAGYMEELYRLQVSE-V--AE---V----TI-QR--LLAL --VVM---GEDKQQ--IEKG--PHGYHFKRSTFSQNGTSAMTSNGNLVTI DKVW-HLAEMNDALLGPRPAL----KHLCMSFSLFK-LLRRRFARYPL-- -VEAGSEKAFHFVRGILLTDGADADPEAV-----FRVITDELSFAWDFYY SSHPISH------LGKWLPIMS-IM-TSLFTMAFCIFIVITLAWKILP-- -------EY---KD--------YRVM-SCE--LTC--GEQ--------D- ------NDRFHD--IGSILFVLVPTISLLLVVLLGEV----WEIISY--- -VCSNWTKVTLVCAYTAK-PSWQKSRIMRRLIACFLWCRCKLMN-YWGDK MGMT-SLLDPCKRK--GH-----------IRHLFRLS---K----AMKPT -K--IPKP-----------VKAAL-----IN-SLKGS-NG----QL-SN- GIASLQKCHLRDDIRWACNGE-GTSDIILVWHIATCIFEIRHM------- --HDPSERHSSP--DE-N-DDMITAIH-------LSKYCA-----YLLAS CPELLPDDTPWSKELYKSAKKITDSVLG--------STDMRCFEFDR--M MQLLSE--KSK----------SNE-VVCK-GVQLGKQLVDGI--Q-N-E- NKGWNMLAEFWSEMMLYVAP-S-DNT--KA-HA---KAIARGGE--L--I --TI------------LWALLTHA---------G-I-------------- -------------I--RRPEHDN--------------------------- -------------------------------------------------- ------------------------VV--- >9 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALSDRS--- ------------------------------------------------R- --------------------ESLLPSFLYT-----SS------------- -------------------------------------------------- -----------AARSF------A-TG-ATR---FPS-------------- ------------------------------------------PV--S-P- -ASPA-PGA----VGGGAPISIQAPREKIEMYSPAFY------------A ACTAGGIA---------------S---CG----------LT--------- ---------HMAVT--PLD-L-VKCNMQIDPA---------KYKSITSGF GVLLK-EQG---------P----RGF-------FRGWVP--TLLGYSA-- -QGACKFGFYEFFKKYYSDI---AGPEYAQK------------------Y KTLIYLA------GSASAEVIA-DVALCP-FEAVKVRVQTQPGFAR---- -G-----L--------SDGL-PKFVR--SE-GALGLYKGIV---PLWGR- ------QIPYTMMKFASFETIVE----MIYKHAVPVP----KSECSK--- -SFQLG-------------------------------------------- -----------------------------------IS---FAGGYI--AG -V--FCAI-----------VSH----PAD--------------------- ---------------------------------------NLVSF------ ---------------L---N-------N-------AKGAT-----VG--- ---DAVKKL-GLWG-----------------------LFTRGLPLRI--V MIGTLT-------------------------------------------- -----------------------------G-------------------- ---A------------QWGIYDAFKVMVGLPTTG-G-------------- -------------VT-PAPGAAEKA------------------------- ----------------------------LQAS-A---------------- ----------------------------- >14 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAVLLNPS-- -----SSSSSKATPR---------------------PPQ-Q----QQLL- -L-LLL-------HLLLVAVPATSLTFSYD--A-DSFVS--EDFRQE-DD A--M-VT-AGR-IE--LL----------GEE--F----AARARGRALYKR PVQLWDGATGEEASFAASFNFTI-RS-VAG---RGN-------------- ------------------------------------------AL--AGH- -GMTFFLAPF----MPDMPQE--CYEGCLGLFDQSLTRN----TA--SAT MGNASGAASFVAVEFDTHMDGW-D---PS----------GR-HV--GVDI NNVDS-RRGNYVVL--PEDSL-VDAGVMSATV---------SYDSGARRL DVALA-IGG--------GA--ATATYNLSAAVHLRSVLPEQVAVGFSA-- -ATGDQFASNHTVLSFTFSS---TLPTRTTNPPQ-PST---------SSA KTAHLSA------AVAAAGIAL-QL-LVL-AITILIRRARKRRRRD---- -D--GVS-----------YD-DSIDD-DDE-EDMESGTGPR---RIPYA- ------HLAAATGGFAEIGKLGEGGSGSVYGGHVRELG---RNVAIK--- -VFTRGASMEGRKEYRSE-VTVISRLRHRNLVQLMGWCHGRRRLLLVYEL VRNG-SLDGHLYSN--KET--LTWPLR--YQIINGLA---SAVLYL--HQ -E--WDQC-----------VVHGDIKPSNIM-LDESF-NA----KL-GDF GLARLIDHGMSLQTMTAVAGTPGYLDPECVITGKASTESDMYSF------ ----GI----VLLEVA---SGRRPMVVTPRAAAATAGGGKDDDDGGG--- ---QVFRLVEWAWELYGRGDDDQ-SSLDAIADTRLGGAFDRWEMERV--V GVGLWC--AHP-------------------DPKARPAIRQAA-EALQS-- RKFRMPVLPPRMPVAVYLQP-FAAST--MKYYG---DSMTSVGS--EVV- ---G-------------YSSTS--LATATLSSSS-S-------------- -------------LP-S-AMA-N-N------------------------- --------------DSLSP-------------RE---------------- ----------------------------- >18 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALSDRS--- ------------------------------------------------R- --------------------ESLLPSFLYS-----TA------------- -------------------------------------------------- -----------GARPY------T-AG-GGG---AAF-------------- ------------------------------------------RL----P- -AAAA-PGG----VGGGAPIEIQAPREKIEMYSPAFY------------A ACTAGGIA---------------S---CG----------LT--------- ---------HMAVT--PLD-L-VKCNMQIDPA---------KYKSITSGF GILAK-EQG---------V----RGF-------FRGWVP--TLLGYSA-- -QGACKFGFYEFFKKYYSDI---AGPEYAQK------------------Y KTLIYLA------GSASAEVIA-DVALCP-FEAVKVRVQTQPGFAR---- -G-----L--------GDGL-PKFIK--SE-GALGLYKGIV---PLWGR- ------QIPYTMMKFASFETIVE----QIYKHAVPVP----KSECSK--- -SFQLG-------------------------------------------- -----------------------------------IS---FAGGYI--AG -V--FCAI-----------VSH----PAD--------------------- ---------------------------------------NLVSF------ ---------------L---N-------N-------AKGAT-----VG--- ---DAVKKL-GLWG-----------------------LFTRGLPLRI--V MIGTLT-------------------------------------------- -----------------------------G-------------------- ---A------------QWGIYDAFKVMVGLPTTG-G-------------- -------------VT-PAPSTSDAG------------------------- ----------------------------LKAVSA---------------- ----------------------------- >26 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAAGVLMT-- -----KPFM-AAA---------------------------A----AALVS -L-LVM-------LRCLPSVVATTVSFNYS-----SFSNASKNITLQGSA A--L-AG-AEW-IE--LT----------KGK--GNNLSSGGTMGRMVYTP PVQLWDAATGEVASFTTRFSFNI-TP-KNK---SNK-------------- -----------------------------------------------GD- -GMTFFLVSY----PSRMPYM--GYGGALGLTSQT--------------- FDNATAGDRFVAVEFDTYNNSFLDP-DAT----------YD-HI--GIDV NALRS--V-KTESL--PSYIL---IGNMTAIV---------DYNSNSSIM SVKLWANGS------------T-TPYNLSSKVDLKSALPEKVAVGFSA-- -ATGSSFE-QHQLRSWYFNL---TLEQKQPT-----GQ-----------H SRGGVVA------GATVGAILFIVL-LFT-MVAILVRRRQRKKMRE---- -E--EED-----------DS-EG----DPI-VEIEMGTGPR---RFPYH- ------ILVNATKSFAAEEKLGQGGFGAVYRGNLREL---GLDVAIK--- -RFAKDSSKQGRKEYKSE-IKVISRLRHRNLVQLIGWCHGRDELLLVYEL VPNR-SLDVHLHGN--GTF--LTWPMR--INIVLGLG---NALLYL--HE -E--WEQC-----------VVHRDIKPSNIM-LDESF-NA----KL-GDF GLARLIDHNVGVQTMTHPSGTPGYLDPECVITGKASAESDVYSF------ ----GV----VLLEVA---CGRRPMSL-L------DNQN-------N--- ---SLFRLVEWVWDLYGQGV-----VLKA-ADERLNNDYDATSMECV--M AVGLWC--AHP-------------------DRYARPSIRAAM-TVLQS-- N-GPLPVLPSKMPVPIYAPP-MASSE--GQL-S---SSTGMSSS--S--- ------------------------LTI----------------------- ----------------T-SIT----------------------------- --------------------------------PR---------------- -----------------------------