Mercurial > repos > ebi-gxa > decoupler_pathway_inference
changeset 10:97c2c52a7ab4 draft default tip
planemo upload for repository https://github.com/ebi-gene-expression-group/container-galaxy-sc-tertiary/ commit b581a5b4ba88c5bf06f6223ba9aec51a8564796c
| author | ebi-gxa |
|---|---|
| date | Fri, 29 Nov 2024 11:34:09 +0000 |
| parents | 81ccee273bc6 |
| children | |
| files | decoupler_pathway_inference.py decoupler_pathway_inference.xml test-data/diff_exp_result.tab |
| diffstat | 3 files changed, 16684 insertions(+), 137 deletions(-) [+] |
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--- a/decoupler_pathway_inference.py Wed Oct 30 14:26:33 2024 +0000 +++ b/decoupler_pathway_inference.py Fri Nov 29 11:34:09 2024 +0000 @@ -10,9 +10,13 @@ # add AnnData input file option parser.add_argument( - "-i", "--input_anndata", help="AnnData input file", required=True + "-i", "--input", + help=( + "AnnData or table input file. Table input is meant for a single " + "comparison, not gene x cells" + ), + required=True ) - # add network input file option parser.add_argument( "-n", "--input_network", help="Network input file", required=True @@ -34,6 +38,28 @@ default=None, ) +# Column for stat to use when providing a table +parser.add_argument( + "--stat", + help="Stat to use when providing a table. Default is 'log2FC'.", + default="log2FC", +) +# Optional column for p-value or FDR in the table +parser.add_argument( + "--p_value_column", + required=False, + help="Column name in the table with p-values or FDRs.", + default=None, +) +# Optional column for FDR threshold when given a table +parser.add_argument( + "--p_value_threshold", + required=False, + type=float, + help="Column name in the table with FDRs.", + default=0.05 +) + # Column name in net with source nodes parser.add_argument( "-s", @@ -93,8 +119,15 @@ if args.output is None: raise ValueError("Please specify either -o or --output") -# read in the AnnData input file -adata = ad.read_h5ad(args.input_anndata) +# detect based on input file extension if the input file is AnnData or matrix +if args.input.endswith(".h5ad"): + input_type = "AnnData" +elif args.input.endswith(".tsv") or args.input.endswith(".csv"): + input_type = "matrix" +else: + raise ValueError( + "Invalid input file. Please provide a valid AnnData or matrix file." + ) # read in the input file network input file network = pd.read_csv(args.input_network, sep="\t") @@ -108,17 +141,32 @@ "Source, target, and weight columns are not present in the network" ) - print(type(args.min_n)) -if args.var_gene_symbols_field and args.var_gene_symbols_field in adata.var.columns: - # Storing index in a column called 'index_bak' - adata.var['index_bak'] = adata.var.index - adata.var.set_index(args.var_gene_symbols_field, inplace=True) +if input_type == "AnnData": + # read in the AnnData input file + adata = ad.read_h5ad(args.input) + if args.var_gene_symbols_field and args.var_gene_symbols_field in adata.var.columns: + # Storing index in a column called 'index_bak' + adata.var['index_bak'] = adata.var.index + adata.var.set_index(args.var_gene_symbols_field, inplace=True) +else: + # read in the matrix input file, genes in rows and columns for stats + adata = pd.read_csv(args.input, sep="\t", index_col=0) + if args.stat not in adata.columns: + raise ValueError(f"Stat column {args.stat} not found in input table header.") + if args.p_value_column and args.p_value_column not in adata.columns: + raise ValueError( + f"P-value column {args.p_value_column} not found in input table header." + ) + if args.p_value_column and args.p_value_threshold is not None: + adata = adata[adata[args.p_value_column] <= args.p_value_threshold] + + adata = adata[[args.stat]].T if args.method == "mlm": - dc.run_mlm( + res = dc.run_mlm( mat=adata, net=network, source=args.source, @@ -129,24 +177,19 @@ use_raw=args.use_raw, ) - if args.output is not None: - # write adata.obsm[mlm_key] and adata.obsm[mlm_pvals_key] to the - # output network files - combined_df = pd.concat( - [adata.obsm["mlm_estimate"], adata.obsm["mlm_pvals"]], axis=1 - ) - - # Save the combined dataframe to a file - combined_df.to_csv(args.output + ".tsv", sep="\t") - - # if args.activities_path is specified, generate the activities AnnData - # and save the AnnData object to the specified path - if args.activities_path is not None: - acts = dc.get_acts(adata, obsm_key="mlm_estimate") - acts.write_h5ad(args.activities_path) - elif args.method == "ulm": - dc.run_ulm( + res = dc.run_ulm( + mat=adata, + net=network, + source=args.source, + target=args.target, + weight=args.weight, + verbose=True, + min_n=args.min_n, + use_raw=args.use_raw, + ) +elif args.method == "consensus": + res = dc.run_consensus( mat=adata, net=network, source=args.source, @@ -157,18 +200,31 @@ use_raw=args.use_raw, ) - if args.output is not None: - # write adata.obsm[mlm_key] and adata.obsm[mlm_pvals_key] to the - # output network files +if args.output is not None: + # write adata.obsm[mlm_key] and adata.obsm[mlm_pvals_key] to the + # output network files + if input_type == "AnnData": combined_df = pd.concat( - [adata.obsm["ulm_estimate"], adata.obsm["ulm_pvals"]], axis=1 + [adata.obsm[f"{args.method}_estimate"], + adata.obsm[f"{args.method}_pvals"]], axis=1 ) + else: + tf_est, tf_pvals = res + combined_df = pd.DataFrame( + { + # index is written, so no need for the set names + f"{args.method}_estimate": tf_est.iloc[0], + f"{args.method}_pvals": tf_pvals.iloc[0], + } + ) + # sort ascending on the p-values + combined_df.sort_values(by=f"{args.method}_pvals", inplace=True) - # Save the combined dataframe to a file - combined_df.to_csv(args.output + ".tsv", sep="\t") + # Save the combined dataframe to a file + combined_df.to_csv(args.output + ".tsv", sep="\t") - # if args.activities_path is specified, generate the activities AnnData - # and save the AnnData object to the specified path - if args.activities_path is not None: - acts = dc.get_acts(adata, obsm_key="ulm_estimate") - acts.write_h5ad(args.activities_path) +# if args.activities_path is specified, generate the activities AnnData +# and save the AnnData object to the specified path +if args.activities_path is not None and input_type == "AnnData": + acts = dc.get_acts(adata, obsm_key=f"{args.method}_estimate") + acts.write_h5ad(args.activities_path)
--- a/decoupler_pathway_inference.xml Wed Oct 30 14:26:33 2024 +0000 +++ b/decoupler_pathway_inference.xml Fri Nov 29 11:34:09 2024 +0000 @@ -1,4 +1,4 @@ -<tool id="decoupler_pathway_inference" name="Decoupler Pathway Inference" version="1.4.0+galaxy2" profile="20.05" license="MIT"> +<tool id="decoupler_pathway_inference" name="Decoupler Pathway Inference" version="1.4.0+galaxy3" profile="20.05" license="MIT"> <description> of functional genesets/pathways for scRNA-seq data. </description> @@ -6,109 +6,165 @@ <requirement type="package" version="1.4.0">decoupler</requirement> </requirements> <command> + #if $inp.format == 'h5ad': + #set $input_fname = "input.h5ad" + #else: + #set $input_fname = "input.tsv" + #end if + ln -s '$input' '$input_fname'; + python '$__tool_directory__/decoupler_pathway_inference.py' - -i '$input_anndata' + -i '$input_fname' -n '$input_network_file' --min_n "$min_n" --method '$method' - $use_raw + --source '$source' --target '$target' --weight '$weight' - #if $gene_symbols_field: - --var_gene_symbols_field '$gene_symbols_field' + #if str($inp.format) == "tabular": + #if $inp.stat_field: + --stat "${inp.stat_field}" + #end if + #if $inp.p_value_column: + --p_value_column "${inp.p_value_column}" + --p_value_threshold "${inp.p_value_threshold}" + #end if + #else: + #if $inp.gene_symbols_field: + --var_gene_symbols_field "${inp.gene_symbols_field}" + #end if + #if $inp.use_raw: + ${inp.use_raw} + #end if + #if $inp.write_activities_path: + ${inp.write_activities_path} + #end if #end if --output "inference" - $write_activities_path + </command> <inputs> - <param name="input_anndata" type="data" format="h5ad" label="Input AnnData file" /> - <param name="input_network_file" type="data" format="tabular" label="Input Network file" help="Tabular file with columns Source, Target and Weight. A source gene/pathway regulates/contains a target gene, weights can be either positive or negative. The source element needs to be part of the network, the target is a gene in the network and in the dataset" /> - <param name="min_n" type="integer" min="0" value="5" label="Minimum targets per source." help="If targets are less than minimum, sources are removed" /> + <param name="input" type="data" format="h5ad,tabular" label="Input AnnData/Expression file"/> + <param name="input_network_file" type="data" format="tabular" label="Input Network file" help="Tabular file with columns Source, Target and Weight. A source gene/pathway regulates/contains a target gene, weights can be either positive or negative. The source element needs to be part of the network, the target is a gene in the network and in the dataset"/> + <param name="min_n" type="integer" min="0" value="5" label="Minimum targets per source." help="If targets are less than minimum, sources are removed"/> + <conditional name="inp"> + <param name="format" type="select" label="Input Format" help="Whether the provided file is AnnData or a Table of differential expression results (usually from bulk)."> + <option value="h5ad">AnnData</option> + <option value="tabular">Differential Expression Table</option> + </param> + <when value="h5ad"> + <param name="use_raw" type="boolean" truevalue="--use_raw" falsevalue="" checked="false" label="Use the raw part of the AnnData object"/> + <param name="write_activities_path" type="boolean" truevalue="--activities_path anndata_activities_path.h5ad" falsevalue="" checked="true" label="Write the activities AnnData object." help="Contains the MLM/ULM/Consensus activity results for each pathway and each cell in the main matrix, it is not a replacement of the original AnnData provided as input."/> + <param name="gene_symbols_field" type="text" optional="true" label="Gene symbols field" help="The field in the AnnData var table where gene symbols are stored."/> + </when> + <when value="tabular"> + <param name="stat_field" type="text" label="Statistic column name" optional="false" help="Defines which column will be passed to the decoupler method, usually you want something like the log2FC or the t-stat (this must be a column in your table)"/> + <param argument="--p_value_column" type="text" label="P-value/FDR column name" help="Defines which column will be passed to the decoupler method as p-value, usually you want something like the log2FC or the t-stat (this must be a column in your table)"/> + <param argument="--p_value_threshold" value="0.05" type="float" label="P-value/FDR thresholds" help="Will filter out any rows in the file that are above the value (in the set P-value/FDR column)"/> + </when> + </conditional> <param name="method" type="select" label="Activity inference method"> <option value="mlm" selected="true">Multivariate linear model (MLM)</option> <option value="ulm">Univariate linear model (ULM)</option> + <option value="consensus">Consensus (use for TFs with CollecTri)</option> </param> - <param name="use_raw" type="boolean" truevalue="--use_raw" falsevalue="" checked="false" label="Use the raw part of the AnnData object" /> - <param name="write_activities_path" type="boolean" truevalue="--activities_path anndata_activities_path.h5ad" falsevalue="" checked="true" label="Write the activities AnnData object." help="Contains the MLM/ULM activity results for each pathway and each cell in the main matrix, it is not a replacement of the original AnnData provided as input."/> - <param name="source" type="text" value='source' label="Column name in network with source nodes." help="Usually the regulators. If empty then default is 'source' is used." /> - <param name="target" type="text" value='target' label="Column name in network with target nodes." help="Usually the regulated genes. If empty then default is 'target' is used." /> - <param name="weight" type="text" value='weight' label="Column name in network with weight." help="If empty then default is 'weight' is used." /> - <param name="gene_symbols_field" type="text" optional="true" label="Gene symbols field" help="The field in the AnnData var table where gene symbols are stored."/> + <param name="source" type="text" value="source" label="Column name in network with source nodes." help="Usually the regulators. If empty then default is 'source' is used."/> + <param name="target" type="text" value="target" label="Column name in network with target nodes." help="Usually the regulated genes. If empty then default is 'target' is used."/> + <param name="weight" type="text" value="weight" label="Column name in network with weight." help="If empty then default is 'weight' is used."/> </inputs> <outputs> <data name="output_ad" format="h5ad" from_work_dir="anndata_activities_path.h5ad" label="${tool.name} on ${on_string}: Regulators/Pathways activity AnnData file"> - <filter>write_activities_path</filter> + <filter>inp['format'] == "h5ad" and inp['write_activities_path'] is True</filter> </data> - <data name="output_table" format="tabular" from_work_dir="inference.tsv" label="${tool.name} on ${on_string}: Output estimate table" /> + <data name="output_table" format="tabular" from_work_dir="inference.tsv" label="${tool.name} on ${on_string}: Output estimate table"/> </outputs> <tests> <!-- Hint: You can use [ctrl+alt+t] after defining the inputs/outputs to auto-scaffold some basic test cases. --> - - <test expect_num_outputs="2"> - <param name="input_anndata" value="pbmc3k_processed.h5ad"/> - <param name="input_network_file" value="progeny_test.tsv"/> - <param name="min_n" value="0"/> - <param name="method" value="mlm"/> - <param name="use_raw" value="false"/> - <param name="write_activities_path" value="true"/> - <param name="source" value="source"/> - <param name="target" value="target"/> - <param name="weight" value="weight"/> - <output name="output_ad"> - <assert_contents> - <has_h5_keys keys="obsm/mlm_estimate"/> - </assert_contents> - </output> - <output name="output_table"> - <assert_contents> - <has_n_columns n="5"/> - </assert_contents> - </output> - </test> - <test> - <param name="input_anndata" value="pbmc3k_processed.h5ad"/> - <param name="input_network_file" value="progeny_test_2.tsv"/> - <param name="min_n" value="0"/> - <param name="method" value="ulm"/> - <param name="use_raw" value="false"/> - <param name="write_activities_path" value="true"/> - <param name="source" value="source"/> - <param name="target" value="target"/> - <param name="weight" value="weight"/> - <output name="output_ad"> - <assert_contents> - <has_h5_keys keys="obsm/ulm_estimate"/> - </assert_contents> - </output> - <output name="output_table"> - <assert_contents> - <has_n_columns n="5"/> - </assert_contents> - </output> - </test> - <test> - <param name="input_anndata" value="mito_counted_anndata.h5ad"/> - <param name="input_network_file" value="mouse_progeny.tsv"/> - <param name="min_n" value="0"/> - <param name="method" value="ulm"/> - <param name="use_raw" value="false"/> - <param name="write_activities_path" value="true"/> - <param name="source" value="source"/> - <param name="target" value="target"/> - <param name="weight" value="weight"/> - <param name="gene_symbols_field" value="Symbol"/> - <output name="output_ad"> - <assert_contents> - <has_h5_keys keys="obsm/ulm_estimate"/> - </assert_contents> - </output> - <output name="output_table"> - <assert_contents> - <has_n_columns n="29"/> - </assert_contents> - </output> - </test> + <test expect_num_outputs="2"> + <param name="input" value="pbmc3k_processed.h5ad"/> + <param name="inp|format" value="h5ad"/> + <param name="input_network_file" value="progeny_test.tsv"/> + <param name="min_n" value="0"/> + <param name="method" value="mlm"/> + <param name="inp|use_raw" value="false"/> + <param name="inp|write_activities_path" value="true"/> + <param name="source" value="source"/> + <param name="target" value="target"/> + <param name="weight" value="weight"/> + <output name="output_ad"> + <assert_contents> + <has_h5_keys keys="obsm/mlm_estimate"/> + </assert_contents> + </output> + <output name="output_table"> + <assert_contents> + <has_n_columns n="5"/> + </assert_contents> + </output> + </test> + <test expect_num_outputs="2"> + <param name="input" value="pbmc3k_processed.h5ad"/> + <param name="inp|format" value="h5ad"/> + <param name="input_network_file" value="progeny_test_2.tsv"/> + <param name="min_n" value="0"/> + <param name="method" value="ulm"/> + <param name="inp|use_raw" value="false"/> + <param name="inp|write_activities_path" value="true"/> + <param name="source" value="source"/> + <param name="target" value="target"/> + <param name="weight" value="weight"/> + <output name="output_ad"> + <assert_contents> + <has_h5_keys keys="obsm/ulm_estimate"/> + </assert_contents> + </output> + <output name="output_table"> + <assert_contents> + <has_n_columns n="5"/> + </assert_contents> + </output> + </test> + <test expect_num_outputs="2"> + <param name="input" value="mito_counted_anndata.h5ad"/> + <param name="inp|format" value="h5ad"/> + <param name="input_network_file" value="mouse_progeny.tsv"/> + <param name="min_n" value="0"/> + <param name="method" value="ulm"/> + <param name="inp|use_raw" value="false"/> + <param name="inp|write_activities_path" value="true"/> + <param name="source" value="source"/> + <param name="target" value="target"/> + <param name="weight" value="weight"/> + <param name="inp|gene_symbols_field" value="Symbol"/> + <output name="output_ad"> + <assert_contents> + <has_h5_keys keys="obsm/ulm_estimate"/> + </assert_contents> + </output> + <output name="output_table"> + <assert_contents> + <has_n_columns n="29"/> + </assert_contents> + </output> + </test> + <test expect_num_outputs="1"> + <param name="input" value="diff_exp_result.tab"/> + <param name="inp|format" value="tabular"/> + <param name="input_network_file" value="progeny_test.tsv"/> + <param name="min_n" value="0"/> + <param name="method" value="mlm"/> + <param name="inp|stat_field" value="log2FoldChange"/> + <param name="inp|write_activities_path" value="false"/> + <param name="source" value="source"/> + <param name="target" value="target"/> + <param name="weight" value="weight"/> + <output name="output_table"> + <assert_contents> + <has_n_columns n="3"/> + </assert_contents> + </output> + </test> </tests> <help> **What it does** @@ -119,34 +175,62 @@ **Description** -This tool extracts pathway activity inference using decoupler. +This tool extracts pathway activity inference using decoupler. For more information on the underlying algorithms, +the `decoupler documentation`_ , in particular the Pathway Activity +and Transcription factor activity inference sections. + +.. _`decoupler documentation`: https://decoupler-py.readthedocs.io/en/latest/ + +**Input** -**Input** +The tool accepts two types of input files: + +1. An AnnData object in H5AD format: -The input file should be an AnnData object in H5AD format. The tool accepts an H5AD file containing raw or normalized data. + - The H5AD file can contain raw or normalized data. + - You can specify whether to use the raw data in the AnnData object instead of the X matrix using the "use_raw" parameter. + - Minimum of targets per source can be specified using "min_n". + +2. A tabular file with differential expression data: -The tool also takes network file containing a collection of pathways and their target genes, with weights for each interaction. - Example: - ``` - source target weight - 0 T1 G01 1.0 - 1 T1 G02 1.0 - 2 T1 G03 0.7 - 3 T2 G04 1.0 - 4 T2 G06 -0.5 - ``` + - The file should have genes in rows (and the first column by the gene symbols). + - The file needs a header, that is, columns names for every column. + - Columns must include at least fields similar to log2FC and a p-value or FDR field. + - If this file is provided, the tool will score each source in the network file according to the differential expression of the provided genes. + +The tool also requires a network file containing a collection of pathways and their target genes, with weights for each interaction. + +Example of a network file: -You can also specify whether to use the raw data in the AnnData object instead of the X matrix using the "use_raw" parameter and Minimum of targets per source using "min_n". ++---------+--------+--------+ +| source | target | weight | ++=========+========+========+ +| T1 | G01 | 1.0 | ++---------+--------+--------+ +| T1 | G02 | 1.0 | ++---------+--------+--------+ +| T1 | G03 | 0.7 | ++---------+--------+--------+ +| T2 | G04 | 1.0 | ++---------+--------+--------+ +| T2 | G06 | -0.5 | ++---------+--------+--------+ **Output** -The tool outputs an AnnData object containing the scores in the "obs" field, and tab-separated text files containing the scores for each cell. +Depending on the input file type, the tool outputs: + +- If an AnnData file is used: -If the "write_activities_path" parameter is set to "true", the tool will write the modified AnnData object to an H5AD file. -If the "write_inference" parameter is set to "true", the tool will output a tab-separated text file containing the scores for each cell. + - An AnnData object containing the scores in the "obs" field. + - Tab-separated text files containing the scores for each cell. + - If the "write_activities_path" parameter is set to "true", the tool will write the modified AnnData object to an H5AD file. + - If the "write_inference" parameter is set to "true", the tool will output a tab-separated text file containing the scores for each cell. +- If a tabular differential expression file is used: + - A tab-separated text file where each source in the network file is scored according to the differential expression of the provided genes. </help> <citations>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/diff_exp_result.tab Fri Nov 29 11:34:09 2024 +0000 @@ -0,0 +1,16407 @@ +Gene log2FoldChange pvalue padj +DOK6 0.51 1.861e-08 0.0003053 +TBX5 -2.129 5.655e-08 0.0004191 +SLC32A1 0.9003 7.664e-08 0.0004191 +IFITM1 -1.687 3.735e-06 0.006809 +NUP93 0.3659 3.373e-06 0.006809 +EMILIN2 1.534 2.976e-06 0.006809 +TPX2 -0.9974 2.097e-06 0.006809 +LAMA2 -1.425 2.39e-06 0.006809 +CAV2 -1.052 3.213e-06 0.006809 +TNN -1.658 8.973e-06 0.01472 +POU3F4 1.181 1.062e-05 0.01584 +COL13A1 -1.647 1.394e-05 0.01592 +IFITM3 -1.61 1.202e-05 0.01592 +SHISA3 -1.477 1.31e-05 0.01592 +LOC285954 1.05 1.456e-05 0.01592 +VEPH1 1.137 2.211e-05 0.02267 +ARHGAP29 -1.526 3.675e-05 0.03547 +KIAA1755 -1.562 3.972e-05 0.0362 +LAMC3 -1.563 4.29e-05 0.03704 +ITM2A -1.398 4.972e-05 0.04078 +DTHD1 1.54 5.594e-05 0.04371 +RBMS1 -0.9139 6.688e-05 0.04988 +CEBPD -1.202 7.859e-05 0.05606 +DMBX1 -1.425 9.529e-05 0.06486 +PAPLN -1.253 9.883e-05 0.06486 +ADM -1.357 0.0001089 0.06872 +COL2A1 -1.187 0.0001424 0.07794 +HS3ST3A1 -1.004 0.0001388 0.07794 +DYSF -1.03 0.0001425 0.07794 +PI16 1.495 0.0001297 0.07794 +CDC42EP5 -1.355 0.0001581 0.08146 +SLC12A8 -0.9425 0.0001589 0.08146 +ZNF391 -1.024 0.0001913 0.09512 +GALNTL2 1.075 0.0002298 0.1109 +C4orf45 1.288 0.0002472 0.1159 +KIF18B -0.8849 0.0002551 0.1162 +KIF20A -0.9505 0.0002972 0.1318 +PDE1B 1.053 0.0003356 0.1449 +BCAN 1.117 0.0003698 0.1477 +APLNR -1.365 0.000378 0.1477 +CILP -1.11 0.0003582 0.1477 +TEC -1.373 0.0003701 0.1477 +KLF5 -0.8177 0.0004159 0.1578 +ACSS2 -0.5578 0.0004232 0.1578 +RAPGEF2 0.3371 0.0004513 0.1645 +C1orf51 -0.6451 0.0005237 0.1665 +IGF2-AS1 -1.235 0.0005835 0.1665 +RPLP0P2 -1.096 0.0005689 0.1665 +COTL1 -0.7376 0.0005886 0.1665 +MYO1D -0.8454 0.0005529 0.1665 +CIAO1 0.2695 0.000522 0.1665 +POU3F3 0.6857 0.000588 0.1665 +CFLAR -0.9694 0.0005598 0.1665 +BHLHE40 -1.127 0.0004785 0.1665 +PLSCR4 -1.317 0.0004978 0.1665 +HECW1 0.5135 0.0005373 0.1665 +KCNQ3 1.147 0.000483 0.1665 +TIMP1 -1.15 0.0005267 0.1665 +CAV1 -1.115 0.0006722 0.1869 +LTBP4 -0.8186 0.0006991 0.1912 +HDAC1 -0.4542 0.0007203 0.1937 +HSPG2 -1.218 0.0007963 0.1947 +CYR61 -1.102 0.0008071 0.1947 +MYOF -1.194 0.0007397 0.1947 +COL4A1 -1.252 0.0007866 0.1947 +NMB 0.8677 0.0007872 0.1947 +ICAM1 -1.144 0.0007795 0.1947 +NOTCH3 -0.7585 0.0007529 0.1947 +MPPED2 0.5135 0.0008344 0.1984 +COL9A1 -0.9755 0.0008905 0.2087 +ACSF2 -1.142 0.0009448 0.2183 +KTN1 -0.3119 0.0009652 0.2199 +ITPR1 -1.118 0.00102 0.226 +PRPS2 -0.722 0.00101 0.226 +FAM180B 1.249 0.001146 0.2399 +POU2F3 -1.273 0.001114 0.2399 +COL5A2 -1.262 0.001155 0.2399 +ZSWIM3 0.438 0.001143 0.2399 +CADM2 0.643 0.001102 0.2399 +ARHGEF17 -0.5462 0.001214 0.2453 +SSC5D -1.126 0.001229 0.2453 +NRN1 0.8605 0.001241 0.2453 +PLAT -1.103 0.001226 0.2453 +SFXN2 -0.8373 0.00126 0.2456 +FMNL2 -0.2466 0.001276 0.2456 +ADAMTS3 -0.6153 0.001288 0.2456 +ADAMTS19 -1.199 0.001348 0.2543 +SH3BP1 -0.9641 0.001367 0.2548 +LEFTY2 -1.225 0.001414 0.2578 +EHBP1 0.3191 0.001414 0.2578 +UAP1L1 -1.113 0.001454 0.2622 +RAB27A -1.073 0.001516 0.2702 +ZNF213 0.3028 0.001604 0.28 +TOMM34 -0.4213 0.001596 0.28 +PERP -0.914 0.001672 0.2888 +OSMR -1.226 0.001749 0.2988 +CDCA3 -0.7986 0.001911 0.3119 +GPR179 0.8394 0.001972 0.3119 +TMC6 -1.078 0.001977 0.3119 +STXBP5L 0.6711 0.001936 0.3119 +HSPA1L 0.8842 0.001851 0.3119 +PLIN2 -0.604 0.001866 0.3119 +GSN -1.117 0.001977 0.3119 +F8A1 0.9911 0.00191 0.3119 +SLC27A6 -1.196 0.001998 0.3121 +COL4A2 -1.013 0.002192 0.3157 +WFDC1 -1.162 0.002149 0.3157 +DSEL 0.6867 0.002194 0.3157 +DOCK6 -0.8158 0.002172 0.3157 +MAN2B1 -0.4688 0.002099 0.3157 +NFKBIZ -0.888 0.002132 0.3157 +OCIAD2 0.7605 0.002108 0.3157 +REST -0.5478 0.002073 0.3157 +ANXA5 -0.8639 0.002075 0.3157 +TRIM13 0.3688 0.002254 0.3216 +ANLN -0.7229 0.002306 0.3261 +AP1S3 -0.8107 0.002352 0.3271 +LOC100859930 0.9008 0.002343 0.3271 +STK17B -0.887 0.00238 0.3281 +BHLHB9 0.4738 0.002441 0.3337 +IL1R1 -1.185 0.00248 0.3362 +CSDA -0.7633 0.002833 0.35 +POSTN -1.176 0.002706 0.35 +HHIPL1 0.8127 0.002742 0.35 +APBA2 0.4314 0.002752 0.35 +CBLN1 1.066 0.002768 0.35 +ALPK2 -1.108 0.002789 0.35 +NFATC2 -1.108 0.002726 0.35 +CN5H6.4 0.7852 0.002792 0.35 +ABHD14B -1.03 0.002859 0.35 +COL8A1 -1.171 0.002841 0.35 +HCG11 -0.8357 0.002844 0.35 +RUNX2 -0.88 0.002632 0.35 +EPB41L2 -0.9145 0.002832 0.35 +COL11A1 -1.145 0.002903 0.3528 +PODN -1.155 0.003085 0.3722 +NET1 -1.015 0.00311 0.3724 +IL13RA1 -1.106 0.003139 0.3731 +RNF207 -0.7995 0.003239 0.3798 +TRPM2 1.05 0.003246 0.3798 +SDF2L1 -0.4649 0.003298 0.3798 +SLCO2A1 -1.094 0.003293 0.3798 +DACT2 -1.06 0.00331 0.3798 +DCXR -0.4101 0.003335 0.38 +BCAM -0.8227 0.003423 0.3873 +FAM46B -1.002 0.00347 0.39 +FOXL1 -1.136 0.003579 0.3965 +SMTN -0.7131 0.003625 0.3965 +SLC6A1 0.7104 0.003616 0.3965 +YY2 -0.5988 0.003612 0.3965 +DEPDC1 -0.755 0.003704 0.3999 +HEPACAM2 1.116 0.003727 0.3999 +WBP5 -0.8485 0.003729 0.3999 +SPSB1 -1.05 0.003878 0.4105 +KIF23 -0.7154 0.003953 0.4105 +C1QL1 -1.072 0.003907 0.4105 +CBLN2 1.072 0.003934 0.4105 +LOC100505806 -1.069 0.003912 0.4105 +POU3F1 0.7912 0.004163 0.4116 +RGS8 0.9341 0.0043 0.4116 +GAD2 0.7494 0.004273 0.4116 +PKP2 -0.9689 0.004316 0.4116 +KIAA0564 -0.4253 0.004323 0.4116 +PIF1 -0.9292 0.004484 0.4116 +OR1F1 0.8391 0.004052 0.4116 +RRN3 0.3764 0.00431 0.4116 +CORO1A 0.4844 0.004098 0.4116 +CRISPLD2 -1.115 0.004242 0.4116 +TOP2A -0.7962 0.004366 0.4116 +ANKRD12 0.3062 0.004161 0.4116 +DHDH -0.811 0.004357 0.4116 +ZNF274 0.3354 0.004118 0.4116 +DPP4 -1.127 0.004023 0.4116 +TMEM169 0.7379 0.004108 0.4116 +CMTM8 -0.7701 0.004417 0.4116 +LAMP3 -0.9384 0.004515 0.4116 +SYNJ2 -0.9266 0.004504 0.4116 +DPY19L2P3 1.061 0.00448 0.4116 +TSC22D4 -0.5131 0.00443 0.4116 +AR -0.5979 0.00436 0.4116 +LOC339862 -1.109 0.004578 0.415 +CCDC152 0.9749 0.004621 0.4165 +NQO2 -0.6663 0.004716 0.4228 +CMTM5 1.096 0.004868 0.4341 +SERPING1 -0.8202 0.004974 0.4411 +TLCD2 -0.9392 0.005095 0.4494 +ATXN7L3B 0.3532 0.005133 0.4503 +APOE -0.9273 0.005183 0.4523 +GPC3 -1.073 0.005233 0.4542 +IRF1 -0.8166 0.00527 0.455 +GNG2 0.3508 0.005368 0.4611 +EPHX1 -0.5381 0.005794 0.4656 +CLEC2D -0.8191 0.005714 0.4656 +PTPRB -1.079 0.005753 0.4656 +NFATC4 -0.93 0.005692 0.4656 +LGALS3 -0.9472 0.005809 0.4656 +OTX2 0.8839 0.005746 0.4656 +UACA -1.058 0.005562 0.4656 +HAPLN3 -0.9001 0.005753 0.4656 +MYO5B -0.982 0.005461 0.4656 +PVRL3 -0.4554 0.005817 0.4656 +PRDM6 -1.068 0.005688 0.4656 +PDLIM7 -0.7154 0.005623 0.4656 +TSPYL4 0.3561 0.005811 0.4656 +CHRM2 0.9253 0.005564 0.4656 +PMEL -1.007 0.005987 0.4666 +GLIPR1 -1.05 0.006001 0.4666 +NLRC5 -0.9957 0.005976 0.4666 +FAM117A -0.4496 0.005934 0.4666 +FAM83D -0.7423 0.006 0.4666 +C7 -1.072 0.005919 0.4666 +SERPINF1 -1.026 0.006158 0.4721 +PLEKHH2 -1.032 0.006134 0.4721 +GYPC -1.042 0.006102 0.4721 +LAMB2 -0.5626 0.006196 0.4728 +SYNPO2 -1.065 0.006232 0.4734 +SLCO4C1 0.9821 0.006278 0.4746 +TNFAIP6 -1.011 0.006348 0.4777 +FKBP10 -0.7909 0.006391 0.4788 +LAMC1 -0.9224 0.006516 0.4827 +FAM150B -1.066 0.006477 0.4827 +TM4SF1 -1.051 0.006532 0.4827 +PCK2 -0.9537 0.006608 0.4832 +ZNF732 -0.949 0.006608 0.4832 +SLC35D2 -0.8576 0.006626 0.4832 +NOTCH2NL -0.517 0.006761 0.4867 +KRT19 -1.027 0.006764 0.4867 +PCDHGB7 1.014 0.006713 0.4867 +LOC100128787 0.9828 0.006919 0.4872 +PLXDC2 -0.554 0.00689 0.4872 +SLFN11 -1.06 0.006835 0.4872 +NEDD4L 0.3903 0.006904 0.4872 +SPATA2 0.3181 0.006851 0.4872 +CDCP1 -1.047 0.007063 0.4931 +USP53 -0.4552 0.007063 0.4931 +TRAF5 -0.9501 0.007369 0.4935 +PHYHIPL 0.4773 0.007331 0.4935 +A2M -1.048 0.00719 0.4935 +C12orf34 0.596 0.007283 0.4935 +LOC255480 -0.9411 0.007153 0.4935 +LOC150622 0.9708 0.007286 0.4935 +LOC100130451 0.9622 0.007342 0.4935 +SNAI1 -1.023 0.00725 0.4935 +BCL2L13 0.1979 0.007251 0.4935 +DSP -0.9805 0.007197 0.4935 +CERS2 -0.484 0.007538 0.4946 +SEMA6C 0.5278 0.007425 0.4946 +LRRC8E -0.8766 0.007533 0.4946 +RRAS -0.8278 0.007486 0.4946 +MASP1 0.6165 0.007535 0.4946 +RHBDF1 -0.6514 0.00761 0.4974 +UBQLN2 0.2471 0.007667 0.4991 +DOCK1 -0.7425 0.007715 0.5003 +DSCAML1 0.6893 0.007823 0.5033 +ZNF197 0.417 0.0078 0.5033 +LRIG3 -0.9736 0.008134 0.5161 +CUX2 0.6015 0.008177 0.5161 +UGGT2 -0.5188 0.008106 0.5161 +HSDL1 0.2664 0.008179 0.5161 +RBPMS -0.7992 0.008079 0.5161 +CD164 -0.757 0.00828 0.5205 +L1TD1 -1.033 0.008321 0.5206 +PRDX6 -0.5123 0.008346 0.5206 +FAM46C -0.9537 0.008391 0.5215 +ADAM33 -0.9939 0.008549 0.5293 +TLK1 -0.2367 0.00876 0.5403 +KCNK2 0.6097 0.008794 0.5404 +POLR3A 0.2868 0.009062 0.5426 +GANAB -0.3036 0.009048 0.5426 +CPOX -0.3403 0.009023 0.5426 +MICA -0.859 0.008998 0.5426 +POU3F2 0.4784 0.008894 0.5426 +AUTS2 0.39 0.009006 0.5426 +SYPL1 -0.4891 0.008937 0.5426 +MSN -0.3958 0.009132 0.5448 +ZCCHC24 -0.9672 0.009169 0.545 +GSTO1 -0.4109 0.009215 0.5458 +XDH 0.954 0.00933 0.5486 +PABPC1L2B 0.8795 0.009309 0.5486 +POGK 0.2803 0.009736 0.5624 +EFEMP2 -0.9948 0.009655 0.5624 +MYADM -0.7661 0.009726 0.5624 +ORC4 0.3291 0.009609 0.5624 +INSM1 0.5511 0.009701 0.5624 +C14orf149 -0.5111 0.01024 0.5647 +MFGE8 -0.6672 0.01011 0.5647 +CEACAM1 -0.981 0.01007 0.5647 +PLEKHA4 -0.8802 0.01021 0.5647 +MERTK -0.7662 0.009946 0.5647 +MARCH4 0.6728 0.0103 0.5647 +GBX2 0.8828 0.01022 0.5647 +SDC4 -0.6983 0.009882 0.5647 +ITGA9 -0.944 0.01008 0.5647 +SCN5A -0.9351 0.01019 0.5647 +MFI2 -0.8345 0.01026 0.5647 +RAB11FIP1 -0.7027 0.01033 0.5647 +TPD52 -0.7816 0.01023 0.5647 +KIAA2022 0.5636 0.01014 0.5647 +TCEAL6 0.8956 0.01016 0.5647 +MORC4 -0.9271 0.0103 0.5647 +POC1B -0.3673 0.01042 0.5659 +MRC2 -0.6332 0.01039 0.5659 +KCTD6 -0.3616 0.01053 0.57 +MEX3A 0.3088 0.01065 0.5708 +ACTN1 -0.7487 0.01061 0.5708 +TICAM1 -0.8589 0.01061 0.5708 +NPC2 -0.6069 0.01078 0.5721 +COL6A6 -0.969 0.01076 0.5721 +ZC3HAV1 -0.6569 0.01073 0.5721 +OAF -0.7698 0.01096 0.5782 +RNASE4 -0.9059 0.01096 0.5782 +CYBASC3 -0.4846 0.011 0.5784 +CSRNP1 -0.5808 0.01106 0.5795 +HLA-B -0.868 0.01116 0.5831 +ZNF689 0.2551 0.01125 0.5858 +SP9 0.9371 0.01128 0.5858 +WASF2 -0.6745 0.0114 0.5886 +SLFN12 -0.9886 0.01141 0.5886 +FLNA -0.614 0.01146 0.5896 +FREM2 -0.9473 0.01154 0.5914 +PDIA3P -0.3457 0.01185 0.5983 +GAS2L2 0.9302 0.01185 0.5983 +FERMT1 -0.9868 0.01187 0.5983 +SEC14L6 -0.9848 0.01193 0.5983 +CSPG5 0.6937 0.01186 0.5983 +C7orf41 0.3768 0.0119 0.5983 +MYBL1 -0.5962 0.01188 0.5983 +HJURP -0.8059 0.01202 0.6014 +SH3BP5L 0.2129 0.01241 0.6059 +DDN 0.7147 0.01244 0.6059 +RAB35 0.2403 0.0124 0.6059 +RBPMS2 -0.6679 0.01232 0.6059 +MYLK3 0.8447 0.01234 0.6059 +ZFYVE20 0.2118 0.01226 0.6059 +ACSL6 0.6116 0.01224 0.6059 +PCDHGB1 -0.8347 0.01224 0.6059 +SYNPO -0.9788 0.01241 0.6059 +ARHGAP17 -0.3736 0.01264 0.6065 +ETFB 0.505 0.01264 0.6065 +CRYBA4 -0.9657 0.01264 0.6065 +F2RL2 -0.9768 0.01251 0.6065 +STOM -0.743 0.01264 0.6065 +C15orf59 0.6647 0.01277 0.6072 +NCAN 0.5804 0.01274 0.6072 +GPC4 -0.7703 0.01277 0.6072 +DES -0.9714 0.01286 0.6096 +LEPREL2 -0.7969 0.01293 0.6112 +GRIN2A 0.6614 0.01302 0.6122 +FAM84B 0.6649 0.01301 0.6122 +CCND1 -0.5753 0.01313 0.6154 +SEPN1 -0.3657 0.01325 0.6177 +CGN -0.7533 0.01333 0.6177 +BAG5 0.2349 0.01328 0.6177 +WWC2 -0.4373 0.01333 0.6177 +ANO6 -0.5992 0.01349 0.6233 +FZD4 -0.8521 0.01357 0.6255 +DIAPH3 -0.7778 0.01367 0.6284 +RUNX1 -0.9599 0.01374 0.6298 +NTS 0.8462 0.01385 0.631 +TBC1D8B -0.9647 0.01381 0.631 +GP5 -0.9553 0.01392 0.6324 +ZNF547 0.5118 0.01398 0.6336 +B2M -0.7496 0.01412 0.6364 +GPANK1 0.3544 0.01412 0.6364 +MYCL1 0.564 0.01419 0.6377 +C15orf42 -0.7478 0.01427 0.6397 +PTP4A3 -0.6072 0.01435 0.6417 +TGFB1I1 -0.8773 0.01443 0.6434 +PTGDR2 -0.9554 0.0147 0.6467 +RARG -0.9358 0.01459 0.6467 +RAB34 -0.8674 0.01459 0.6467 +DSC2 -0.6871 0.0147 0.6467 +FZD5 -0.654 0.01478 0.6467 +KLHL18 0.249 0.01466 0.6467 +PCDHGB5 -0.956 0.01477 0.6467 +EFNA1 -0.7949 0.01488 0.6476 +KIAA0087 0.9528 0.01488 0.6476 +AURKA -0.652 0.01506 0.6535 +GAL3ST3 0.4134 0.01511 0.654 +WNT7A 0.7548 0.01515 0.6543 +C10orf105 0.8882 0.01528 0.6553 +TUBA1C -0.6215 0.01531 0.6553 +ADAMTS9 -0.8947 0.01534 0.6553 +PNMA2 0.4278 0.01524 0.6553 +MAN1C1 -0.5596 0.01579 0.6597 +CDC20 -0.7767 0.01562 0.6597 +PACSIN3 -0.8907 0.01553 0.6597 +PTHLH -0.9265 0.01572 0.6597 +DAZL -0.9135 0.01572 0.6597 +SRA1 0.3041 0.01559 0.6597 +ARPC1B -0.6737 0.0158 0.6597 +IMMP2L -0.4426 0.01559 0.6597 +ROR2 -0.9148 0.01578 0.6597 +PIEZO1 -0.7733 0.0159 0.6621 +SOCS3 -0.9404 0.01601 0.6634 +LOC150568 0.8026 0.01601 0.6634 +RASL12 -0.8837 0.01609 0.665 +SATL1 0.8447 0.01618 0.6671 +C1orf27 -0.3158 0.01624 0.6679 +TMEM198 0.4547 0.01647 0.6739 +MYOT -0.928 0.01645 0.6739 +PLAU -0.8276 0.01655 0.6749 +GPC6 -0.5345 0.01662 0.6749 +COPZ2 -0.9194 0.01661 0.6749 +MTHFR 0.2998 0.01729 0.6753 +PARD3 -0.3704 0.01726 0.6753 +PDIA3 -0.3509 0.01708 0.6753 +TPM1 -0.7177 0.01711 0.6753 +PRC1 -0.5474 0.01718 0.6753 +PLK1 -0.6854 0.01672 0.6753 +PIEZO2 -0.8503 0.01699 0.6753 +ZNF90 -0.7327 0.0169 0.6753 +GALP 0.8155 0.01693 0.6753 +LOC440905 -0.8935 0.01671 0.6753 +RFTN1 -0.8999 0.01677 0.6753 +TMEM196 0.7006 0.01701 0.6753 +NOD1 -0.5152 0.01707 0.6753 +GLI3 -0.8242 0.01696 0.6753 +WBSCR27 -0.9343 0.01718 0.6753 +C7orf34 0.9318 0.01721 0.6753 +FRRS1 -0.8998 0.01774 0.676 +FAM19A3 -0.8923 0.01788 0.676 +CNIH3 -0.4817 0.01784 0.676 +MDK -0.7156 0.01749 0.676 +GXYLT1 -0.6944 0.01783 0.676 +CTDSP2 -0.5123 0.01765 0.676 +SIX4 -0.8657 0.01784 0.676 +SLCO3A1 0.4415 0.01784 0.676 +PTBP1 -0.4376 0.0178 0.676 +ZNF324 0.3139 0.01754 0.676 +COLEC11 -0.9194 0.01776 0.676 +APOBEC3B -0.9292 0.01771 0.676 +MAGEF1 0.3826 0.01768 0.676 +SHROOM2 0.5668 0.01763 0.676 +KIAA1217 -0.7442 0.01871 0.69 +ST8SIA1 0.3806 0.01869 0.69 +LOC338758 0.6997 0.01834 0.69 +LOC283731 -0.4064 0.01872 0.69 +LYSMD4 0.4181 0.01859 0.69 +CYP1B1 -0.9248 0.01834 0.69 +PDGFRB -0.9184 0.01853 0.69 +FKBP5 -0.7347 0.01841 0.69 +AGBL3 0.5843 0.01861 0.69 +MNX1 0.921 0.01864 0.69 +PHKA2 -0.4551 0.01855 0.69 +CCBL2 -0.3365 0.01892 0.6925 +CLIC5 -0.9123 0.01883 0.6925 +WDR67 -0.3832 0.01887 0.6925 +SLC38A5 -0.7194 0.01895 0.6925 +KLF4 -0.8767 0.01907 0.6951 +HSD17B11 -0.6032 0.0192 0.6985 +SLC2A3 -0.5111 0.0193 0.7005 +CSDAP1 -0.7114 0.01946 0.7046 +SBNO2 -0.3452 0.01955 0.7064 +LRRC4C 0.5704 0.01962 0.7074 +ATL3 -0.5278 0.01975 0.7074 +C1S -0.9056 0.01966 0.7074 +PLAUR -0.8162 0.01974 0.7074 +LOC256021 0.6774 0.01988 0.709 +EID2B 0.4332 0.01987 0.709 +MTA3 -0.4227 0.02009 0.7151 +BSG -0.2869 0.02023 0.7167 +LAMP2 -0.2974 0.02022 0.7167 +ATHL1 -0.9069 0.02033 0.7179 +AHNAK -0.7987 0.02044 0.7179 +IGFBP5 -0.9055 0.02035 0.7179 +MBOAT1 -0.7067 0.02044 0.7179 +EGFR -0.6912 0.02048 0.7179 +FRAT1 0.4904 0.02073 0.7201 +TBX10 -0.9015 0.02084 0.7201 +KCNA6 0.4245 0.02068 0.7201 +MATN3 -0.8883 0.02079 0.7201 +LTBP1 -0.8212 0.02081 0.7201 +SCARF2 -0.7426 0.02064 0.7201 +BAI3 0.3512 0.02085 0.7201 +LOC654433 0.828 0.02096 0.7226 +GTSE1 -0.5797 0.02106 0.7229 +SCRG1 -0.9048 0.02106 0.7229 +AHCY -0.5073 0.02111 0.7231 +LRRTM3 0.609 0.02122 0.7239 +MYO1C -0.7078 0.02121 0.7239 +AKR1E2 0.7441 0.02134 0.7264 +PCDHGB4 -0.8844 0.02142 0.7277 +P2RX4 -0.3807 0.02159 0.7309 +LINC00574 0.7267 0.02161 0.7309 +BPI -0.8613 0.02171 0.7313 +ATP2B2 0.751 0.02167 0.7313 +CDCA2 -0.6352 0.0218 0.7328 +FGF8 -0.8835 0.02191 0.7338 +FAM198A -0.8977 0.02192 0.7338 +FMO2 -0.8029 0.0222 0.7401 +LOC642852 0.5471 0.02215 0.7401 +IGF2R -0.5322 0.02227 0.741 +TIGD3 0.6643 0.02236 0.7426 +GFPT2 -0.6006 0.02241 0.7429 +BCAS2 0.3073 0.02266 0.7431 +IQGAP3 -0.7145 0.02274 0.7431 +ZDHHC20 -0.3828 0.02266 0.7431 +ARID4A 0.2039 0.02278 0.7431 +SPHK1 -0.8455 0.02253 0.7431 +FAM110C -0.7952 0.02259 0.7431 +PXDN -0.7352 0.02275 0.7431 +THSD7B -0.5467 0.02268 0.7431 +PRUNE 0.2438 0.02292 0.7459 +ECE1 -0.7102 0.02311 0.7477 +CECR7 0.8781 0.02308 0.7477 +HTRA3 -0.8843 0.02303 0.7477 +WDR47 0.4054 0.0234 0.7537 +SLITRK5 0.4093 0.02345 0.7537 +AURKB -0.6811 0.02349 0.7537 +IGFBP4 -0.8858 0.02352 0.7537 +CDC25C -0.6363 0.02348 0.7537 +GPM6A 0.649 0.02357 0.7538 +BTBD19 -0.7584 0.02376 0.755 +GPR26 0.7615 0.02388 0.755 +SIAH3 0.7351 0.02393 0.755 +PLCB2 -0.8363 0.02385 0.755 +DNM1P35 0.6404 0.02389 0.755 +RRBP1 -0.8115 0.0238 0.755 +ACOT8 0.3293 0.02375 0.755 +OLFML2B -0.8708 0.02414 0.7572 +TROAP -0.7143 0.02411 0.7572 +WIPI1 -0.6362 0.02411 0.7572 +VOPP1 0.2574 0.02422 0.7584 +HES1 -0.5633 0.02436 0.7611 +FIBIN -0.8826 0.02444 0.7624 +KDELC2 -0.8298 0.02449 0.7625 +ERRFI1 -0.5181 0.02486 0.767 +ZNF26 0.2525 0.0249 0.767 +RAB20 -0.7225 0.02495 0.767 +CEP112 -0.5528 0.02496 0.767 +PDYN 0.8461 0.02487 0.767 +SEL1L3 -0.794 0.0249 0.767 +CENPE -0.581 0.02474 0.767 +LOC100505695 -0.8418 0.02506 0.7684 +ST3GAL6 0.3335 0.02515 0.7698 +PPPDE1 -0.3884 0.02552 0.7705 +CYFIP1 -0.4708 0.02549 0.7705 +SPAG5 -0.6341 0.02525 0.7705 +FSTL3 -0.3936 0.02544 0.7705 +DKKL1 -0.5961 0.02555 0.7705 +PLA2R1 -0.8383 0.02533 0.7705 +SH3RF2 -0.8594 0.02543 0.7705 +NEDD9 -0.5615 0.02537 0.7705 +LOC400940 0.7406 0.02573 0.7737 +NPR2 -0.6064 0.02575 0.7737 +CKS1B -0.6537 0.02617 0.778 +RNASEL 0.8586 0.02631 0.778 +KIAA1462 -0.8624 0.02641 0.778 +C10orf2 0.3805 0.02618 0.778 +PRKCDBP -0.8186 0.02624 0.778 +ZNF564 0.3025 0.02598 0.778 +LOC100506421 0.6526 0.02601 0.778 +SNED1 -0.8004 0.02611 0.778 +SGMS2 -0.8683 0.02638 0.778 +TMEM151B 0.4716 0.02635 0.778 +LOC100507341 0.6623 0.02622 0.778 +KIF2C -0.6374 0.02666 0.7837 +PRX -0.6445 0.02676 0.7854 +LOXL4 -0.8597 0.02686 0.7864 +STXBP6 0.6668 0.02689 0.7864 +FAM13A -0.4611 0.02712 0.7917 +IFITM10 0.6685 0.02744 0.7925 +CBFB -0.3576 0.02735 0.7925 +DKFZp566F0947 -0.8205 0.02736 0.7925 +MAGI2 0.4314 0.02741 0.7925 +NIPAL2 -0.7441 0.0274 0.7925 +GPRASP2 0.4453 0.02732 0.7925 +DPH3P1 -0.5664 0.02774 0.7999 +C1orf54 -0.5484 0.02801 0.8025 +LIG4 0.3168 0.02811 0.8025 +GREM1 -0.8574 0.02807 0.8025 +TPM4 -0.6659 0.028 0.8025 +OSBPL10 -0.7943 0.02789 0.8025 +HPS3 -0.3542 0.02812 0.8025 +ANP32B -0.4906 0.02825 0.8047 +FAM176B -0.6818 0.02966 0.8067 +HPCAL4 0.5034 0.02927 0.8067 +LEPRE1 -0.7027 0.03137 0.8067 +MCOLN3 -0.7816 0.02861 0.8067 +GBP3 -0.8426 0.03082 0.8067 +SELENBP1 -0.7428 0.03013 0.8067 +LMNA -0.499 0.03161 0.8067 +KCNJ9 0.7358 0.02904 0.8067 +CENPL -0.3831 0.02874 0.8067 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0.03105 0.8067 +ZNF703 -0.6856 0.03162 0.8067 +ST18 0.5283 0.03123 0.8067 +LOC100132891 -0.7824 0.03111 0.8067 +C8orf84 -0.7652 0.03183 0.8067 +ZFHX4 0.4288 0.03044 0.8067 +GDF6 -0.8041 0.03241 0.8067 +RANBP6 0.3012 0.03171 0.8067 +FAM189A2 -0.8114 0.0328 0.8067 +TNC -0.8197 0.03225 0.8067 +ZBTB6 0.3295 0.02968 0.8067 +RPL12 -0.5342 0.02943 0.8067 +GBGT1 -0.8343 0.03067 0.8067 +ARHGAP6 -0.8167 0.03244 0.8067 +SHROOM4 -0.645 0.03263 0.8067 +HDX 0.4208 0.03269 0.8067 +COL4A5 -0.7708 0.03259 0.8067 +GAB3 -0.7788 0.03107 0.8067 +B3GALNT2 -0.5213 0.03322 0.809 +ZNF142 0.2381 0.03314 0.809 +HEXB -0.4081 0.03323 0.809 +PPP1R3G -0.8344 0.03314 0.809 +MDFIC -0.6575 0.03324 0.809 +RXFP3 0.832 0.03336 0.8098 +PTTG3P -0.6051 0.03333 0.8098 +C1orf133 -0.7152 0.03375 0.8176 +TP53I13 -0.422 0.03379 0.8176 +SLC44A3 -0.7081 0.03438 0.8264 +C1orf115 -0.6315 0.03446 0.8264 +ANO4 -0.7486 0.03437 0.8264 +FNIP2 0.2913 0.03444 0.8264 +CRHBP -0.8231 0.03437 0.8264 +KIAA0368 -0.3228 0.0344 0.8264 +PLCE1 -0.7467 0.03491 0.8277 +PARPBP -0.5436 0.0348 0.8277 +FRMD6 -0.7527 0.03488 0.8277 +LIN7B 0.5171 0.03464 0.8277 +COL4A3BP -0.5851 0.03462 0.8277 +SCML4 0.7487 0.03473 0.8277 +ZNF815 0.3814 0.03489 0.8277 +DIRAS2 0.4271 0.03474 0.8277 +SULT1A1 -0.7929 0.03504 0.8292 +ADAMTS9-AS2 -0.7074 0.03508 0.8292 +CHTOP 0.2474 0.03521 0.8311 +DKK2 -0.8042 0.03534 0.8331 +HIST1H1D -0.8219 0.03541 0.8335 +CDK1 -0.5524 0.03609 0.8345 +SHISA2 -0.8216 0.03606 0.8345 +GJD2 0.6358 0.03608 0.8345 +CCNB2 -0.6054 0.0358 0.8345 +OMG 0.805 0.03565 0.8345 +MYL4 -0.7755 0.03625 0.8345 +LOC100131096 -0.7581 0.03632 0.8345 +HSPB6 -0.8208 0.03557 0.8345 +STEAP3 -0.5503 0.0359 0.8345 +OSGEPL1 0.2775 0.03631 0.8345 +APOL4 -0.8187 0.03588 0.8345 +BAP1 0.1786 0.03614 0.8345 +PHLDB2 -0.8077 0.03626 0.8345 +NAP1L5 0.4839 0.03554 0.8345 +CFI -0.7104 0.0361 0.8345 +SORBS3 -0.6631 0.03587 0.8345 +TOP1MT -0.4407 0.03585 0.8345 +OPLAH -0.4763 0.03653 0.8383 +ASAP3 -0.2714 0.03787 0.8394 +TSG101 0.2283 0.03752 0.8394 +CPT1A -0.3581 0.0378 0.8394 +GALNT6 -0.7937 0.03784 0.8394 +KCNK10 0.5243 0.03782 0.8394 +ISL2 0.8166 0.03724 0.8394 +GOLGA6L10 0.8026 0.03693 0.8394 +TMEM100 -0.8097 0.03759 0.8394 +TBC1D16 0.2885 0.03692 0.8394 +JUNB -0.5495 0.03735 0.8394 +ZNF614 0.2666 0.03762 0.8394 +ZNF600 -0.742 0.0372 0.8394 +TCF7L1 -0.5031 0.03767 0.8394 +ACOX2 -0.7993 0.03678 0.8394 +FAM107A 0.8057 0.03704 0.8394 +FGFBP2 -0.7944 0.03791 0.8394 +LOC644100 0.8085 0.03748 0.8394 +CPEB4 0.477 0.03704 0.8394 +GUCA1A 0.4614 0.03744 0.8394 +CALD1 -0.7359 0.03704 0.8394 +EPHB6 0.6366 0.03748 0.8394 +PENK -0.8034 0.03669 0.8394 +TMEM74 0.5734 0.03704 0.8394 +RPS6 -0.5392 0.03785 0.8394 +OLFML2A -0.6171 0.03745 0.8394 +PLP2 -0.6977 0.03664 0.8394 +VASH1 0.3249 0.03799 0.8399 +GRIP1 0.4312 0.03808 0.8408 +PDE1A 0.6831 0.03824 0.8421 +PKD2 -0.5166 0.03824 0.8421 +C14orf39 -0.7682 0.03839 0.8434 +SCPEP1 -0.6581 0.0384 0.8434 +CTNNA3 -0.8021 0.03904 0.8447 +LTBP3 -0.6738 0.03908 0.8447 +TRAFD1 0.1378 0.0388 0.8447 +HAUS4 -0.5229 0.03918 0.8447 +ADSSL1 -0.5 0.03864 0.8447 +ZKSCAN2 0.3948 0.03912 0.8447 +SLC39A3 0.3176 0.03887 0.8447 +NTF4 -0.8096 0.03852 0.8447 +MORC2 0.1997 0.03885 0.8447 +GNL1 0.262 0.03901 0.8447 +ANKS1A 0.4512 0.03879 0.8447 +BMP1 -0.4547 0.03914 0.8447 +TCEAL8 -0.6073 0.03858 0.8447 +MBNL3 -0.7198 0.03893 0.8447 +RND1 0.5434 0.0393 0.8462 +DNAJC3 -0.3772 0.03952 0.8475 +TMEM121 0.7264 0.03957 0.8475 +CHEK2 -0.5046 0.03945 0.8475 +PALLD -0.4758 0.03954 0.8475 +SPOCD1 -0.7888 0.03989 0.8487 +NCDN 0.3799 0.03986 0.8487 +CHD1L -0.3283 0.03979 0.8487 +RPP25 0.6103 0.03981 0.8487 +IMPA2 -0.5937 0.03978 0.8487 +CHRNB2 0.6312 0.04002 0.8493 +LAYN -0.8004 0.04001 0.8493 +PKNOX2 0.4366 0.04012 0.8503 +ANXA2 -0.6618 0.04034 0.852 +VGLL3 -0.7837 0.04032 0.852 +RASL11B -0.7901 0.04035 0.852 +C3orf58 -0.5738 0.04046 0.8531 +HIRIP3 0.2689 0.04051 0.8532 +ZNF696 0.2746 0.04063 0.8546 +DDX12P -0.7561 0.04101 0.8551 +TANC1 -0.7275 0.04096 0.8551 +CDH10 0.3894 0.04102 0.8551 +VCAN -0.4669 0.04076 0.8551 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0.9251 +PRR7 0.1904 0.06493 0.9251 +LOC729678 0.6278 0.06551 0.9251 +HIST1H3J -0.6119 0.06763 0.9251 +ZBTB22 0.2669 0.06404 0.9251 +KIFC1 -0.549 0.06264 0.9251 +TBP 0.2407 0.0661 0.9251 +PMS2CL 0.3408 0.06648 0.9251 +FKBP14 -0.6002 0.06604 0.9251 +FKBP9 -0.4174 0.06186 0.9251 +GRM3 0.6129 0.06304 0.9251 +EPHB4 -0.6453 0.06787 0.9251 +LRRN3 0.5473 0.068 0.9251 +KIAA1147 0.257 0.06708 0.9251 +FAM115A 0.2185 0.06468 0.9251 +PDIA4 -0.4169 0.06375 0.9251 +ZNF775 0.2417 0.06198 0.9251 +FAM110B 0.2576 0.0615 0.9251 +DMRT3 0.7178 0.06674 0.9251 +CDKN2B -0.7039 0.06592 0.9251 +TSTD2 0.2954 0.06597 0.9251 +PTGES -0.7016 0.06267 0.9251 +FIBCD1 -0.6829 0.06516 0.9251 +STARD8 -0.7074 0.06244 0.9251 +KLHL4 -0.6903 0.0657 0.9251 +SH2D1A -0.6782 0.06569 0.9251 +HLX -0.6728 0.06837 0.927 +FOSB -0.6318 0.06832 0.927 +AKR1C3 -0.7137 0.06854 0.9278 +NFE2L2 -0.3512 0.06853 0.9278 +TRIP10 -0.5324 0.06872 0.9279 +ZNF14 0.3806 0.06869 0.9279 +DAB2 -0.5142 0.06862 0.9279 +CCNE1 -0.4662 0.06905 0.9309 +CRTAP -0.5294 0.06906 0.9309 +MYBPHL -0.6574 0.06967 0.9317 +RAB13 -0.5093 0.07021 0.9317 +IFITM2 -0.7098 0.06986 0.9317 +WEE1 -0.349 0.07071 0.9317 +LIN7C 0.3113 0.07001 0.9317 +NEAT1 -0.5604 0.06935 0.9317 +PRICKLE1 -0.6021 0.06958 0.9317 +TNFRSF12A -0.525 0.07083 0.9317 +ROGDI 0.3456 0.06977 0.9317 +CLEC16A 0.197 0.06923 0.9317 +TRADD -0.6894 0.0708 0.9317 +ATXN7L3 0.2479 0.07036 0.9317 +COIL 0.2361 0.06995 0.9317 +SPAST 0.3323 0.07065 0.9317 +RQCD1 0.2386 0.07059 0.9317 +HDLBP -0.3856 0.07093 0.9317 +ZNF502 0.7101 0.06932 0.9317 +LRRC58 -0.3642 0.07076 0.9317 +C4orf48 0.2925 0.07013 0.9317 +HMX1 -0.702 0.07093 0.9317 +SLC39A8 -0.3564 0.06976 0.9317 +PARP8 0.26 0.07093 0.9317 +AGXT2L2 -0.4154 0.07086 0.9317 +HIST1H4K -0.6587 0.07053 0.9317 +MDFI -0.4686 0.0692 0.9317 +TFEB -0.5835 0.07031 0.9317 +SOBP 0.2902 0.0707 0.9317 +EPM2A 0.3081 0.0706 0.9317 +RASEF -0.7099 0.07028 0.9317 +TOR2A 0.1958 0.07037 0.9317 +EFNB1 -0.4579 0.07022 0.9317 +IRS4 -0.6417 0.07016 0.9317 +FMNL1 0.5174 0.07107 0.9322 +CABLES2 0.1954 0.07108 0.9322 +PALMD -0.7062 0.07154 0.933 +ARHGAP30 0.4733 0.07142 0.933 +SLC6A12 -0.6354 0.0716 0.933 +FBXL8 -0.669 0.0716 0.933 +MPP4 -0.6609 0.07149 0.933 +FAM169A 0.2892 0.07155 0.933 +POPDC3 -0.6543 0.07148 0.933 +PRKDC -0.3408 0.07144 0.933 +MTCP1NB -0.3672 0.07166 0.9331 +KLHL35 0.547 0.07195 0.9361 +LOC388630 -0.6851 0.07216 0.9373 +TERF2 0.2403 0.07216 0.9373 +PDIK1L 0.3225 0.07438 0.9393 +CDKN2C -0.5881 0.07417 0.9393 +STAM 0.2146 0.07258 0.9393 +CEP55 -0.5626 0.07374 0.9393 +OAT -0.3282 0.07472 0.9393 +DPYSL4 0.3403 0.07368 0.9393 +INCENP -0.4533 0.07294 0.9393 +FLJ39051 0.4429 0.07465 0.9393 +TNFRSF1A -0.5017 0.07441 0.9393 +EMP1 -0.6983 0.07371 0.9393 +LRRK2 -0.638 0.07436 0.9393 +HMGA2 -0.6418 0.07437 0.9393 +PAWR -0.4633 0.07481 0.9393 +KDELC1 -0.4797 0.07463 0.9393 +STOML1 0.44 0.073 0.9393 +CPLX3 0.5793 0.07442 0.9393 +IQGAP1 -0.5202 0.07443 0.9393 +UNC45A -0.399 0.07369 0.9393 +QPRT -0.459 0.07395 0.9393 +FHOD1 -0.5817 0.07342 0.9393 +PMFBP1 -0.6728 0.07513 0.9393 +VPS53 0.2412 0.07388 0.9393 +GSG2 -0.5565 0.07526 0.9393 +DNAH2 0.5147 0.0737 0.9393 +MRM1 0.4208 0.07515 0.9393 +MPP2 0.354 0.07332 0.9393 +ITGB4 -0.6953 0.07405 0.9393 +CCDC68 -0.696 0.07529 0.9393 +SALL3 0.49 0.07403 0.9393 +TMC4 -0.5552 0.0751 0.9393 +ZNF329 0.2676 0.07305 0.9393 +ZNF324B 0.4072 0.07329 0.9393 +MAT2A 0.3537 0.0727 0.9393 +RND3 0.4659 0.07447 0.9393 +IL5RA 0.6958 0.07526 0.9393 +TUSC2 0.3129 0.07499 0.9393 +TACC3 -0.4554 0.07503 0.9393 +RGS12 0.2794 0.07467 0.9393 +KLHL8 0.2803 0.07494 0.9393 +CXXC4 0.3722 0.07323 0.9393 +RAB33B -0.3195 0.07345 0.9393 +LRP2BP 0.5095 0.0735 0.9393 +RIOK1 0.2755 0.07471 0.9393 +GUSB -0.289 0.07272 0.9393 +WNT16 -0.6902 0.07499 0.9393 +MTMR9 0.4022 0.07321 0.9393 +RB1CC1 0.1851 0.07324 0.9393 +LOC100130301 -0.6884 0.07526 0.9393 +ZHX2 -0.1906 0.07262 0.9393 +C8orf31 0.662 0.07311 0.9393 +PTPLAD2 -0.6807 0.07516 0.9393 +ANGPTL2 -0.6812 0.0727 0.9393 +XKR9 0.6838 0.07538 0.9397 +NPM3 -0.43 0.07558 0.9414 +NGF -0.6824 0.07589 0.9417 +WDR37 0.2218 0.076 0.9417 +NPFFR1 0.6156 0.07579 0.9417 +GIPC3 -0.696 0.07581 0.9417 +ERBB4 0.5386 0.07567 0.9417 +GHR -0.6939 0.07599 0.9417 +VWDE -0.6838 0.07595 0.9417 +RPS4X -0.5797 0.0761 0.9423 +CDK2AP2 -0.3551 0.07631 0.9432 +LOC146336 0.693 0.07658 0.9432 +UBE2C -0.6278 0.07624 0.9432 +C22orf39 0.2448 0.07654 0.9432 +MFSD7 -0.6817 0.07645 0.9432 +CANX -0.2312 0.07664 0.9432 +VIPR2 0.6908 0.07663 0.9432 +PPP1R3B -0.5682 0.07643 0.9432 +TMEM229B 0.5479 0.0767 0.9433 +PCDH17 0.2916 0.07683 0.9434 +HOXA10 -0.6931 0.0768 0.9434 +SYT12 0.5719 0.077 0.9434 +FLJ44054 -0.6519 0.07698 0.9434 +BASP1 0.4201 0.07695 0.9434 +NCAPH2 0.2371 0.07719 0.9445 +PLA1A -0.5791 0.07721 0.9445 +EGFLAM -0.6643 0.07726 0.9445 +CD151 -0.3897 0.0774 0.9449 +STX11 -0.677 0.07738 0.9449 +APRT -0.3698 0.07756 0.9456 +PTPN2 -0.342 0.07763 0.9456 +PRRT4 0.5432 0.07763 0.9456 +ARRDC2 -0.5913 0.0778 0.9469 +POLD4 -0.613 0.07788 0.9471 +LDLRAP1 -0.6823 0.07828 0.9475 +SYDE2 -0.558 0.07807 0.9475 +TP53BP2 -0.3194 0.07848 0.9475 +ADAM12 -0.5572 0.07815 0.9475 +GAL3ST2 0.6873 0.07821 0.9475 +CTNND2 0.2648 0.07819 0.9475 +TSPAN13 0.4076 0.0783 0.9475 +RPS2P32 0.6489 0.0784 0.9475 +SLC26A7 -0.6902 0.07843 0.9475 +C9orf7 0.2083 0.07848 0.9475 +CDCA8 -0.5135 0.0788 0.9479 +MKNK1 -0.2483 0.07956 0.9479 +TOMM40L 0.3821 0.0791 0.9479 +PTGS2 -0.6878 0.07897 0.9479 +DNAJC1 -0.4755 0.07904 0.9479 +TLL2 0.5684 0.07932 0.9479 +PSD 0.5206 0.07953 0.9479 +LIMA1 -0.4947 0.07919 0.9479 +RBMS2 -0.4759 0.07932 0.9479 +CKAP4 -0.3698 0.07866 0.9479 +EEF1DP3 0.6545 0.07897 0.9479 +TAX1BP3 -0.4054 0.07874 0.9479 +LOC653653 -0.4477 0.0791 0.9479 +ZNF512 0.2908 0.07935 0.9479 +SNHG11 0.2322 0.07955 0.9479 +CDH22 0.6411 0.07954 0.9479 +PTK7 -0.5221 0.07951 0.9479 +ZP3 -0.6679 0.07931 0.9479 +TMEM53 0.3107 0.08059 0.9479 +LRRC7 0.3219 0.08033 0.9479 +GSTM2 -0.5028 0.08061 0.9479 +CASP7 -0.4341 0.08068 0.9479 +PPFIBP2 -0.6376 0.08024 0.9479 +THAP2 0.2884 0.07976 0.9479 +HSP90AB4P -0.6784 0.08068 0.9479 +DET1 0.2051 0.08049 0.9479 +CYLD 0.319 0.08012 0.9479 +BCL3 -0.6233 0.0806 0.9479 +VWC2L 0.6372 0.07974 0.9479 +RNF25 0.1676 0.08019 0.9479 +CNTN4 0.504 0.07976 0.9479 +CISH -0.5241 0.08075 0.9479 +HADH -0.4319 0.08056 0.9479 +PCDHB11 0.4955 0.07996 0.9479 +GSR -0.1539 0.08022 0.9479 +GAS1 -0.6786 0.08036 0.9479 +RALGPS1 0.3386 0.08055 0.9479 +ASS1 -0.5933 0.07979 0.9479 +MAGT1 -0.483 0.08078 0.9479 +FOXRED1 0.2663 0.08087 0.9484 +APOBEC3F -0.6398 0.08099 0.9486 +PNMA6C 0.6833 0.08101 0.9486 +NYNRIN -0.5606 0.08159 0.9534 +PAFAH1B1 0.2687 0.08149 0.9534 +HLA-DPB1 -0.6257 0.08158 0.9534 +ACADL -0.6423 0.08166 0.9535 +TMCO4 -0.68 0.08216 0.9575 +STX12 0.2526 0.08372 0.9575 +LPPR5 0.4957 0.08319 0.9575 +SLC16A1 -0.3904 0.08384 0.9575 +HIST2H2AC -0.6177 0.08331 0.9575 +UNC5B -0.655 0.08316 0.9575 +DLG2 0.4321 0.08343 0.9575 +EPS8 -0.5223 0.0829 0.9575 +TMED10 -0.2748 0.08272 0.9575 +ZNF668 0.2764 0.08363 0.9575 +CDH5 -0.6796 0.08264 0.9575 +SERPINF2 -0.6734 0.08263 0.9575 +CCL2 -0.6794 0.08289 0.9575 +NSF 0.2745 0.08307 0.9575 +TBX2 -0.5658 0.0821 0.9575 +NANP -0.3152 0.08238 0.9575 +LAMA5 -0.4893 0.08354 0.9575 +APOL1 -0.6811 0.08247 0.9575 +RPL14 -0.537 0.08355 0.9575 +TXNRD3 -0.5488 0.08316 0.9575 +PEX5L 0.623 0.08268 0.9575 +LOC152217 0.4514 0.08238 0.9575 +TMEM171 -0.6135 0.08386 0.9575 +LRRC1 -0.3878 0.08257 0.9575 +SIM1 0.6275 0.0826 0.9575 +BVES -0.249 0.08263 0.9575 +LINC00242 0.5716 0.08302 0.9575 +PHF14 0.1599 0.08393 0.9575 +PLOD3 -0.4068 0.08346 0.9575 +XKR5 -0.6356 0.08384 0.9575 +RHOBTB2 0.4079 0.08357 0.9575 +ANXA1 -0.6786 0.08292 0.9575 +ATP2B3 0.5396 0.0839 0.9575 +SMAP2 0.2954 0.08422 0.9598 +MELK -0.5682 0.08424 0.9598 +IFI16 -0.6473 0.0848 0.9611 +LRRC52 0.6609 0.08565 0.9611 +HHAT -0.4914 0.08442 0.9611 +INPPL1 -0.3374 0.08545 0.9611 +TUBA1B -0.2308 0.08554 0.9611 +AACS -0.4244 0.08516 0.9611 +IGDCC4 -0.6063 0.08495 0.9611 +CD276 -0.2418 0.08544 0.9611 +ACAN -0.675 0.08512 0.9611 +LINC00526 0.4174 0.08504 0.9611 +ZNF675 0.2529 0.08507 0.9611 +IRF2BP1 0.189 0.08564 0.9611 +NEU4 0.6273 0.0854 0.9611 +CXADR 0.2793 0.08566 0.9611 +PDCD6IP -0.3005 0.08529 0.9611 +CHSY3 -0.6706 0.08494 0.9611 +PPP1R10 0.4539 0.08556 0.9611 +AMPH 0.4514 0.08561 0.9611 +MEGF9 0.3088 0.08556 0.9611 +MIR181A2HG 0.4623 0.0857 0.9611 +RPL7A -0.4194 0.08505 0.9611 +KIF4A -0.4928 0.08548 0.9611 +MORF4L2 -0.4217 0.0847 0.9611 +CORO1B -0.275 0.08577 0.9611 +IL34 -0.6733 0.08602 0.9627 +WNT5A -0.604 0.08596 0.9627 +PABPC3 -0.4561 0.08631 0.9632 +MCF2L 0.4215 0.08624 0.9632 +SAMD14 0.2885 0.08656 0.9632 +ZFP28 0.6693 0.08651 0.9632 +ZNF300 0.6722 0.08654 0.9632 +GTF2E2 -0.3225 0.0862 0.9632 +FNBP1 -0.3116 0.08656 0.9632 +PTGDS -0.6437 0.08661 0.9632 +ARSE -0.6553 0.08666 0.9632 +TMSB15B -0.449 0.08644 0.9632 +ROBO3 0.6583 0.08676 0.9637 +PPP1R26 0.2834 0.08692 0.9649 +SLC25A45 -0.6618 0.08698 0.9649 +ZSCAN2 0.2606 0.08722 0.9659 +WDR73 0.2182 0.08726 0.9659 +CCDC8 -0.5492 0.08734 0.9659 +KPNA4 0.1613 0.08735 0.9659 +GPSM1 0.3101 0.08737 0.9659 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-0.4586 0.08997 0.9724 +LOC100289178 -0.5336 0.09209 0.9726 +CSF1 -0.5422 0.0909 0.9726 +ATP1A4 0.6566 0.09242 0.9726 +ASPM -0.5813 0.09211 0.9726 +VIM -0.3059 0.09239 0.9726 +FGFBP3 0.5134 0.09256 0.9726 +TMEM180 0.3082 0.09306 0.9726 +LRFN4 0.2951 0.09052 0.9726 +CLPB 0.2353 0.09255 0.9726 +CCDC82 0.2191 0.09305 0.9726 +EXPH5 -0.6385 0.09019 0.9726 +SHMT2 -0.4061 0.09325 0.9726 +STARD13 -0.5916 0.09152 0.9726 +NDRG2 -0.3444 0.09292 0.9726 +DIO3 -0.6516 0.0904 0.9726 +CATSPER2 -0.5356 0.09049 0.9726 +KIAA1024 0.4764 0.09062 0.9726 +SYT17 0.5178 0.09162 0.9726 +SLC6A2 -0.6315 0.09254 0.9726 +MT1F -0.5865 0.092 0.9726 +SREBF1 -0.2865 0.09019 0.9726 +FAM18B1 0.2447 0.09048 0.9726 +SLFN5 -0.6274 0.09319 0.9726 +PECAM1 -0.5699 0.09272 0.9726 +RIT2 0.6243 0.09292 0.9726 +SKA1 -0.5624 0.09233 0.9726 +ZNF132 0.6444 0.09192 0.9726 +PQLC3 -0.6393 0.09059 0.9726 +CCDC85A 0.5345 0.09219 0.9726 +ITGA4 -0.6476 0.09164 0.9726 +PP14571 0.4537 0.09165 0.9726 +COL6A1 -0.6322 0.09046 0.9726 +S100B -0.6302 0.09097 0.9726 +IFT27 0.2014 0.09252 0.9726 +NPTXR 0.4734 0.09322 0.9726 +TMEM108 0.4143 0.09141 0.9726 +JAKMIP1 0.5669 0.0922 0.9726 +PRDM8 0.4432 0.09296 0.9726 +MANBA -0.4409 0.09101 0.9726 +BBS7 0.1647 0.09211 0.9726 +CLCN3 0.2052 0.0931 0.9726 +LOC100505738 0.6572 0.09096 0.9726 +NLN 0.236 0.09043 0.9726 +PCDHB7 0.6516 0.09285 0.9726 +RGS14 -0.4462 0.09072 0.9726 +CBY3 0.5688 0.09162 0.9726 +HIST1H2AM -0.6372 0.09291 0.9726 +HLA-C -0.5912 0.09104 0.9726 +ELOVL5 -0.2373 0.09108 0.9726 +FAM46A -0.3156 0.09168 0.9726 +RPS12 -0.5287 0.09263 0.9726 +CCDC136 0.4087 0.09176 0.9726 +TRPS1 -0.3614 0.09141 0.9726 +ANXA2P2 -0.5766 0.09133 0.9726 +SRPK3 -0.6556 0.09069 0.9726 +CSRNP3 0.2731 0.09361 0.9757 +ZC3H12A -0.5278 0.09392 0.976 +C10orf88 0.2803 0.09416 0.976 +GPC5 0.4252 0.09386 0.976 +F7 -0.6455 0.09405 0.976 +SSTR2 0.4515 0.09396 0.976 +CDH7 0.4489 0.09399 0.976 +BCR 0.1753 0.09415 0.976 +RGS20 -0.4782 0.09417 0.976 +ERCC6L -0.527 0.09376 0.976 +ZNF674 0.269 0.09424 0.9761 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