changeset 3:64a48e3412f2 draft

Uploaded
author glogobyte
date Wed, 13 Oct 2021 11:18:47 +0000
parents 2ae5bf8c80a3
children 216888953a0a
files README.md
diffstat 1 files changed, 1572 insertions(+), 0 deletions(-) [+]
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--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/README.md	Wed Oct 13 11:18:47 2021 +0000
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+                  <div class="dropdown-menu flex-auto rounded px-0 pt-2 pb-0 mt-0 pb-4 p-lg-4 position-relative position-lg-absolute left-0 left-lg-n4">
+                    <ul class="list-style-none mb-3">
+                      <li class="edge-item-fix"><a href="/explore" class="py-2 lh-condensed-ultra d-block Link--primary no-underline h5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Explore">Explore GitHub <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                    </ul>
+
+                    <h4 class="color-fg-muted text-normal text-mono f5 mb-2 border-lg-top pt-lg-3">Learn and contribute</h4>
+                    <ul class="list-style-none mb-3">
+                      <li class="edge-item-fix"><a href="/topics" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Topics">Topics <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                        <li class="edge-item-fix"><a href="/collections" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Collections">Collections <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                      <li class="edge-item-fix"><a href="/trending" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Trending">Trending <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                      <li class="edge-item-fix"><a href="https://lab.github.com/" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Learning lab">Learning Lab <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                      <li class="edge-item-fix"><a href="https://opensource.guide" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Open source guides">Open source guides <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                    </ul>
+
+                    <h4 class="color-fg-muted text-normal text-mono f5 mb-2 border-lg-top pt-lg-3">Connect with others</h4>
+                    <ul class="list-style-none mb-0">
+                      <li class="edge-item-fix"><a href="https://github.com/readme" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover">The ReadME Project <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                      <li class="edge-item-fix"><a href="https://github.com/events" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Events">Events <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                      <li class="edge-item-fix"><a href="https://github.community" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Community forum">Community forum <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                      <li class="edge-item-fix"><a href="https://education.github.com" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to GitHub Education">GitHub Education <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                      <li class="edge-item-fix"><a href="https://stars.github.com" class="py-2 pb-0 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to GitHub Stars Program">GitHub Stars program <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                    </ul>
+                  </div>
+                </details>
+              </li>
+
+              <li class="border-bottom border-lg-bottom-0 mr-0 mr-lg-3">
+                <a href="/marketplace" class="HeaderMenu-link no-underline py-3 d-block d-lg-inline-block" data-ga-click="(Logged out) Header, go to Marketplace">Marketplace</a>
+              </li>
+
+              <li class="d-block d-lg-flex flex-lg-nowrap flex-lg-items-center border-bottom border-lg-bottom-0 mr-0 mr-lg-3 edge-item-fix position-relative flex-wrap flex-justify-between d-flex flex-items-center ">
+                <details class="HeaderMenu-details details-overlay details-reset width-full">
+                  <summary class="HeaderMenu-summary HeaderMenu-link px-0 py-3 border-0 no-wrap d-block d-lg-inline-block">
+                    Pricing
+                    <svg x="0px" y="0px" viewBox="0 0 14 8" xml:space="preserve" fill="none" class="icon-chevon-down-mktg position-absolute position-lg-relative">
+                       <path d="M1,1l6.2,6L13,1"></path>
+                    </svg>
+                  </summary>
+
+                  <div class="dropdown-menu flex-auto rounded px-0 pt-2 pb-4 mt-0 p-lg-4 position-relative position-lg-absolute left-0 left-lg-n4">
+                    <a href="/pricing" class="pb-2 lh-condensed-ultra d-block Link--primary no-underline h5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Pricing">Plans <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a>
+
+                    <ul class="list-style-none mb-3">
+                      <li class="edge-item-fix"><a href="/pricing#feature-comparison" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Compare plans">Compare plans <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                      <li class="edge-item-fix"><a href="https://github.com/enterprise/contact" class="py-2 lh-condensed-ultra d-block Link--secondary no-underline f5 Bump-link--hover" data-ga-click="(Logged out) Header, go to Contact Sales">Contact Sales <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                    </ul>
+
+                    <ul class="list-style-none mb-0 border-lg-top pt-lg-3">
+                      <li class="edge-item-fix"><a href="https://education.github.com" class="py-2 pb-0 lh-condensed-ultra d-block no-underline Link--primary no-underline h5 Bump-link--hover"  data-ga-click="(Logged out) Header, go to Education">Education <span class="Bump-link-symbol float-right text-normal color-fg-muted pr-3">&rarr;</span></a></li>
+                    </ul>
+                  </div>
+                </details>
+              </li>
+          </ul>
+        </nav>
+
+      <div class="d-lg-flex flex-items-center px-3 px-lg-0 text-center text-lg-left">
+          <div class="d-lg-flex min-width-0 mb-3 mb-lg-0">
+            
+
+
+
+<div class="header-search flex-auto js-site-search position-relative flex-self-stretch flex-md-self-auto mb-3 mb-md-0 mr-0 mr-md-3 scoped-search site-scoped-search js-jump-to"
+>
+  <div class="position-relative">
+    <!-- '"` --><!-- </textarea></xmp> --></option></form><form class="js-site-search-form" role="search" aria-label="Site" data-scope-type="Repository" data-scope-id="323269699" data-scoped-search-url="/Glogobyte/isomiR_tools/search" data-owner-scoped-search-url="/users/Glogobyte/search" data-unscoped-search-url="/search" action="/Glogobyte/isomiR_tools/search" accept-charset="UTF-8" method="get">
+      <label class="form-control input-sm header-search-wrapper p-0 js-chromeless-input-container header-search-wrapper-jump-to position-relative d-flex flex-justify-between flex-items-center">
+        <input type="text"
+          class="form-control input-sm header-search-input jump-to-field js-jump-to-field js-site-search-focus js-site-search-field is-clearable"
+          data-hotkey=s,/
+          name="q"
+          data-test-selector="nav-search-input"
+          placeholder="Search"
+          data-unscoped-placeholder="Search GitHub"
+          data-scoped-placeholder="Search"
+          autocapitalize="off"
+          role="combobox"
+          aria-haspopup="listbox"
+          aria-expanded="false"
+          aria-autocomplete="list"
+          aria-controls="jump-to-results"
+          aria-label="Search"
+          data-jump-to-suggestions-path="/_graphql/GetSuggestedNavigationDestinations"
+          spellcheck="false"
+          autocomplete="off"
+        >
+        <input type="hidden" data-csrf="true" class="js-data-jump-to-suggestions-path-csrf" value="DzB6IH6TeIu2fl/kDbJzKnrn9xKy5uu9z1L0rEt4vgQiSv4sYYXkGRJZ/AnL5IVvBN6ObdGtnIP/4bBd3jf5AA==" />
+        <input type="hidden" class="js-site-search-type-field" name="type" >
+            <svg xmlns="http://www.w3.org/2000/svg" width="22" height="20" aria-hidden="true" class="mr-1 header-search-key-slash"><path fill="none" stroke="#979A9C" opacity=".4" d="M3.5.5h12c1.7 0 3 1.3 3 3v13c0 1.7-1.3 3-3 3h-12c-1.7 0-3-1.3-3-3v-13c0-1.7 1.3-3 3-3z"></path><path fill="#979A9C" d="M11.8 6L8 15.1h-.9L10.8 6h1z"></path></svg>
+
+
+          <div class="Box position-absolute overflow-hidden d-none jump-to-suggestions js-jump-to-suggestions-container">
+            
+<ul class="d-none js-jump-to-suggestions-template-container">
+  
+
+<li class="d-flex flex-justify-start flex-items-center p-0 f5 navigation-item js-navigation-item js-jump-to-suggestion" role="option">
+  <a tabindex="-1" class="no-underline d-flex flex-auto flex-items-center jump-to-suggestions-path js-jump-to-suggestion-path js-navigation-open p-2" href="" data-item-type="suggestion">
+    <div class="jump-to-octicon js-jump-to-octicon flex-shrink-0 mr-2 text-center d-none">
+      <svg title="Repository" aria-label="Repository" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-repo js-jump-to-octicon-repo d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M2 2.5A2.5 2.5 0 014.5 0h8.75a.75.75 0 01.75.75v12.5a.75.75 0 01-.75.75h-2.5a.75.75 0 110-1.5h1.75v-2h-8a1 1 0 00-.714 1.7.75.75 0 01-1.072 1.05A2.495 2.495 0 012 11.5v-9zm10.5-1V9h-8c-.356 0-.694.074-1 .208V2.5a1 1 0 011-1h8zM5 12.25v3.25a.25.25 0 00.4.2l1.45-1.087a.25.25 0 01.3 0L8.6 15.7a.25.25 0 00.4-.2v-3.25a.25.25 0 00-.25-.25h-3.5a.25.25 0 00-.25.25z"></path>
+</svg>
+      <svg title="Project" aria-label="Project" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-project js-jump-to-octicon-project d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M1.75 0A1.75 1.75 0 000 1.75v12.5C0 15.216.784 16 1.75 16h12.5A1.75 1.75 0 0016 14.25V1.75A1.75 1.75 0 0014.25 0H1.75zM1.5 1.75a.25.25 0 01.25-.25h12.5a.25.25 0 01.25.25v12.5a.25.25 0 01-.25.25H1.75a.25.25 0 01-.25-.25V1.75zM11.75 3a.75.75 0 00-.75.75v7.5a.75.75 0 001.5 0v-7.5a.75.75 0 00-.75-.75zm-8.25.75a.75.75 0 011.5 0v5.5a.75.75 0 01-1.5 0v-5.5zM8 3a.75.75 0 00-.75.75v3.5a.75.75 0 001.5 0v-3.5A.75.75 0 008 3z"></path>
+</svg>
+      <svg title="Search" aria-label="Search" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-search js-jump-to-octicon-search d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M11.5 7a4.499 4.499 0 11-8.998 0A4.499 4.499 0 0111.5 7zm-.82 4.74a6 6 0 111.06-1.06l3.04 3.04a.75.75 0 11-1.06 1.06l-3.04-3.04z"></path>
+</svg>
+    </div>
+
+    <img class="avatar mr-2 flex-shrink-0 js-jump-to-suggestion-avatar d-none" alt="" aria-label="Team" src="" width="28" height="28">
+
+    <div class="jump-to-suggestion-name js-jump-to-suggestion-name flex-auto overflow-hidden text-left no-wrap css-truncate css-truncate-target">
+    </div>
+
+    <div class="border rounded-1 flex-shrink-0 color-bg-tertiary px-1 color-text-tertiary ml-1 f6 d-none js-jump-to-badge-search">
+      <span class="js-jump-to-badge-search-text-default d-none" aria-label="in this repository">
+        In this repository
+      </span>
+      <span class="js-jump-to-badge-search-text-global d-none" aria-label="in all of GitHub">
+        All GitHub
+      </span>
+      <span aria-hidden="true" class="d-inline-block ml-1 v-align-middle">↵</span>
+    </div>
+
+    <div aria-hidden="true" class="border rounded-1 flex-shrink-0 color-bg-tertiary px-1 color-text-tertiary ml-1 f6 d-none d-on-nav-focus js-jump-to-badge-jump">
+      Jump to
+      <span class="d-inline-block ml-1 v-align-middle">↵</span>
+    </div>
+  </a>
+</li>
+
+</ul>
+
+<ul class="d-none js-jump-to-no-results-template-container">
+  <li class="d-flex flex-justify-center flex-items-center f5 d-none js-jump-to-suggestion p-2">
+    <span class="color-text-secondary">No suggested jump to results</span>
+  </li>
+</ul>
+
+<ul id="jump-to-results" role="listbox" class="p-0 m-0 js-navigation-container jump-to-suggestions-results-container js-jump-to-suggestions-results-container">
+  
+
+<li class="d-flex flex-justify-start flex-items-center p-0 f5 navigation-item js-navigation-item js-jump-to-scoped-search d-none" role="option">
+  <a tabindex="-1" class="no-underline d-flex flex-auto flex-items-center jump-to-suggestions-path js-jump-to-suggestion-path js-navigation-open p-2" href="" data-item-type="scoped_search">
+    <div class="jump-to-octicon js-jump-to-octicon flex-shrink-0 mr-2 text-center d-none">
+      <svg title="Repository" aria-label="Repository" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-repo js-jump-to-octicon-repo d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M2 2.5A2.5 2.5 0 014.5 0h8.75a.75.75 0 01.75.75v12.5a.75.75 0 01-.75.75h-2.5a.75.75 0 110-1.5h1.75v-2h-8a1 1 0 00-.714 1.7.75.75 0 01-1.072 1.05A2.495 2.495 0 012 11.5v-9zm10.5-1V9h-8c-.356 0-.694.074-1 .208V2.5a1 1 0 011-1h8zM5 12.25v3.25a.25.25 0 00.4.2l1.45-1.087a.25.25 0 01.3 0L8.6 15.7a.25.25 0 00.4-.2v-3.25a.25.25 0 00-.25-.25h-3.5a.25.25 0 00-.25.25z"></path>
+</svg>
+      <svg title="Project" aria-label="Project" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-project js-jump-to-octicon-project d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M1.75 0A1.75 1.75 0 000 1.75v12.5C0 15.216.784 16 1.75 16h12.5A1.75 1.75 0 0016 14.25V1.75A1.75 1.75 0 0014.25 0H1.75zM1.5 1.75a.25.25 0 01.25-.25h12.5a.25.25 0 01.25.25v12.5a.25.25 0 01-.25.25H1.75a.25.25 0 01-.25-.25V1.75zM11.75 3a.75.75 0 00-.75.75v7.5a.75.75 0 001.5 0v-7.5a.75.75 0 00-.75-.75zm-8.25.75a.75.75 0 011.5 0v5.5a.75.75 0 01-1.5 0v-5.5zM8 3a.75.75 0 00-.75.75v3.5a.75.75 0 001.5 0v-3.5A.75.75 0 008 3z"></path>
+</svg>
+      <svg title="Search" aria-label="Search" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-search js-jump-to-octicon-search d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M11.5 7a4.499 4.499 0 11-8.998 0A4.499 4.499 0 0111.5 7zm-.82 4.74a6 6 0 111.06-1.06l3.04 3.04a.75.75 0 11-1.06 1.06l-3.04-3.04z"></path>
+</svg>
+    </div>
+
+    <img class="avatar mr-2 flex-shrink-0 js-jump-to-suggestion-avatar d-none" alt="" aria-label="Team" src="" width="28" height="28">
+
+    <div class="jump-to-suggestion-name js-jump-to-suggestion-name flex-auto overflow-hidden text-left no-wrap css-truncate css-truncate-target">
+    </div>
+
+    <div class="border rounded-1 flex-shrink-0 color-bg-tertiary px-1 color-text-tertiary ml-1 f6 d-none js-jump-to-badge-search">
+      <span class="js-jump-to-badge-search-text-default d-none" aria-label="in this repository">
+        In this repository
+      </span>
+      <span class="js-jump-to-badge-search-text-global d-none" aria-label="in all of GitHub">
+        All GitHub
+      </span>
+      <span aria-hidden="true" class="d-inline-block ml-1 v-align-middle">↵</span>
+    </div>
+
+    <div aria-hidden="true" class="border rounded-1 flex-shrink-0 color-bg-tertiary px-1 color-text-tertiary ml-1 f6 d-none d-on-nav-focus js-jump-to-badge-jump">
+      Jump to
+      <span class="d-inline-block ml-1 v-align-middle">↵</span>
+    </div>
+  </a>
+</li>
+
+  
+
+<li class="d-flex flex-justify-start flex-items-center p-0 f5 navigation-item js-navigation-item js-jump-to-owner-scoped-search d-none" role="option">
+  <a tabindex="-1" class="no-underline d-flex flex-auto flex-items-center jump-to-suggestions-path js-jump-to-suggestion-path js-navigation-open p-2" href="" data-item-type="owner_scoped_search">
+    <div class="jump-to-octicon js-jump-to-octicon flex-shrink-0 mr-2 text-center d-none">
+      <svg title="Repository" aria-label="Repository" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-repo js-jump-to-octicon-repo d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M2 2.5A2.5 2.5 0 014.5 0h8.75a.75.75 0 01.75.75v12.5a.75.75 0 01-.75.75h-2.5a.75.75 0 110-1.5h1.75v-2h-8a1 1 0 00-.714 1.7.75.75 0 01-1.072 1.05A2.495 2.495 0 012 11.5v-9zm10.5-1V9h-8c-.356 0-.694.074-1 .208V2.5a1 1 0 011-1h8zM5 12.25v3.25a.25.25 0 00.4.2l1.45-1.087a.25.25 0 01.3 0L8.6 15.7a.25.25 0 00.4-.2v-3.25a.25.25 0 00-.25-.25h-3.5a.25.25 0 00-.25.25z"></path>
+</svg>
+      <svg title="Project" aria-label="Project" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-project js-jump-to-octicon-project d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M1.75 0A1.75 1.75 0 000 1.75v12.5C0 15.216.784 16 1.75 16h12.5A1.75 1.75 0 0016 14.25V1.75A1.75 1.75 0 0014.25 0H1.75zM1.5 1.75a.25.25 0 01.25-.25h12.5a.25.25 0 01.25.25v12.5a.25.25 0 01-.25.25H1.75a.25.25 0 01-.25-.25V1.75zM11.75 3a.75.75 0 00-.75.75v7.5a.75.75 0 001.5 0v-7.5a.75.75 0 00-.75-.75zm-8.25.75a.75.75 0 011.5 0v5.5a.75.75 0 01-1.5 0v-5.5zM8 3a.75.75 0 00-.75.75v3.5a.75.75 0 001.5 0v-3.5A.75.75 0 008 3z"></path>
+</svg>
+      <svg title="Search" aria-label="Search" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-search js-jump-to-octicon-search d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M11.5 7a4.499 4.499 0 11-8.998 0A4.499 4.499 0 0111.5 7zm-.82 4.74a6 6 0 111.06-1.06l3.04 3.04a.75.75 0 11-1.06 1.06l-3.04-3.04z"></path>
+</svg>
+    </div>
+
+    <img class="avatar mr-2 flex-shrink-0 js-jump-to-suggestion-avatar d-none" alt="" aria-label="Team" src="" width="28" height="28">
+
+    <div class="jump-to-suggestion-name js-jump-to-suggestion-name flex-auto overflow-hidden text-left no-wrap css-truncate css-truncate-target">
+    </div>
+
+    <div class="border rounded-1 flex-shrink-0 color-bg-tertiary px-1 color-text-tertiary ml-1 f6 d-none js-jump-to-badge-search">
+      <span class="js-jump-to-badge-search-text-default d-none" aria-label="in this user">
+        In this user
+      </span>
+      <span class="js-jump-to-badge-search-text-global d-none" aria-label="in all of GitHub">
+        All GitHub
+      </span>
+      <span aria-hidden="true" class="d-inline-block ml-1 v-align-middle">↵</span>
+    </div>
+
+    <div aria-hidden="true" class="border rounded-1 flex-shrink-0 color-bg-tertiary px-1 color-text-tertiary ml-1 f6 d-none d-on-nav-focus js-jump-to-badge-jump">
+      Jump to
+      <span class="d-inline-block ml-1 v-align-middle">↵</span>
+    </div>
+  </a>
+</li>
+
+  
+
+<li class="d-flex flex-justify-start flex-items-center p-0 f5 navigation-item js-navigation-item js-jump-to-global-search d-none" role="option">
+  <a tabindex="-1" class="no-underline d-flex flex-auto flex-items-center jump-to-suggestions-path js-jump-to-suggestion-path js-navigation-open p-2" href="" data-item-type="global_search">
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+      <svg title="Repository" aria-label="Repository" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-repo js-jump-to-octicon-repo d-none flex-shrink-0">
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+</svg>
+      <svg title="Search" aria-label="Search" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-search js-jump-to-octicon-search d-none flex-shrink-0">
+    <path fill-rule="evenodd" d="M11.5 7a4.499 4.499 0 11-8.998 0A4.499 4.499 0 0111.5 7zm-.82 4.74a6 6 0 111.06-1.06l3.04 3.04a.75.75 0 11-1.06 1.06l-3.04-3.04z"></path>
+</svg>
+    </div>
+
+    <img class="avatar mr-2 flex-shrink-0 js-jump-to-suggestion-avatar d-none" alt="" aria-label="Team" src="" width="28" height="28">
+
+    <div class="jump-to-suggestion-name js-jump-to-suggestion-name flex-auto overflow-hidden text-left no-wrap css-truncate css-truncate-target">
+    </div>
+
+    <div class="border rounded-1 flex-shrink-0 color-bg-tertiary px-1 color-text-tertiary ml-1 f6 d-none js-jump-to-badge-search">
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+        In this repository
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+        All GitHub
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+      <span aria-hidden="true" class="d-inline-block ml-1 v-align-middle">↵</span>
+    </div>
+
+    <div aria-hidden="true" class="border rounded-1 flex-shrink-0 color-bg-tertiary px-1 color-text-tertiary ml-1 f6 d-none d-on-nav-focus js-jump-to-badge-jump">
+      Jump to
+      <span class="d-inline-block ml-1 v-align-middle">↵</span>
+    </div>
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+</ul>
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+          </div>
+      </label>
+</form>  </div>
+</div>
+
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+
+        <div class="position-relative mr-3 mb-4 mb-lg-0 d-inline-block">
+          <a href="/login?return_to=https%3A%2F%2Fgithub.com%2FGlogobyte%2FisomiR_tools%2Fblob%2Fmain%2FREADME.md"
+            class="HeaderMenu-link flex-shrink-0 no-underline"
+            data-hydro-click="{&quot;event_type&quot;:&quot;authentication.click&quot;,&quot;payload&quot;:{&quot;location_in_page&quot;:&quot;site header menu&quot;,&quot;repository_id&quot;:null,&quot;auth_type&quot;:&quot;SIGN_UP&quot;,&quot;originating_url&quot;:&quot;https://github.com/Glogobyte/isomiR_tools/blob/main/README.md&quot;,&quot;user_id&quot;:null}}" data-hydro-click-hmac="8b29456fe52d52060d3773bc1ef662577aa2a485ec748664cc6a54d9c6f917cf"
+            data-ga-click="(Logged out) Header, clicked Sign in, text:sign-in">
+            Sign in
+          </a>
+        </div>
+
+            <a href="/signup?ref_cta=Sign+up&amp;ref_loc=header+logged+out&amp;ref_page=%2F%3Cuser-name%3E%2F%3Crepo-name%3E%2Fblob%2Fshow&amp;source=header-repo&amp;source_repo=Glogobyte%2FisomiR_tools"
+              class="HeaderMenu-link flex-shrink-0 d-inline-block no-underline border color-border-default rounded px-2 py-1"
+              data-hydro-click="{&quot;event_type&quot;:&quot;authentication.click&quot;,&quot;payload&quot;:{&quot;location_in_page&quot;:&quot;site header menu&quot;,&quot;repository_id&quot;:null,&quot;auth_type&quot;:&quot;SIGN_UP&quot;,&quot;originating_url&quot;:&quot;https://github.com/Glogobyte/isomiR_tools/blob/main/README.md&quot;,&quot;user_id&quot;:null}}" data-hydro-click-hmac="8b29456fe52d52060d3773bc1ef662577aa2a485ec748664cc6a54d9c6f917cf"
+              data-hydro-click="{&quot;event_type&quot;:&quot;analytics.event&quot;,&quot;payload&quot;:{&quot;category&quot;:&quot;Sign up&quot;,&quot;action&quot;:&quot;click to sign up for account&quot;,&quot;label&quot;:&quot;ref_page:/&lt;user-name&gt;/&lt;repo-name&gt;/blob/show;ref_cta:Sign up;ref_loc:header logged out&quot;,&quot;originating_url&quot;:&quot;https://github.com/Glogobyte/isomiR_tools/blob/main/README.md&quot;,&quot;user_id&quot;:null}}" data-hydro-click-hmac="10b5589e3d935965ad52ca5d4bf93859e37d170f4f71e7efd5ec52c09a6e8b19"
+            >
+              Sign up
+            </a>
+      </div>
+    </div>
+  </div>
+</header>
+
+    </div>
+
+  <div id="start-of-content" class="show-on-focus"></div>
+
+
+
+
+
+
+    <div data-pjax-replace id="js-flash-container">
+
+
+  <template class="js-flash-template">
+    <div class="flash flash-full  {{ className }}">
+  <div class=" px-2" >
+    <button class="flash-close js-flash-close" type="button" aria-label="Dismiss this message">
+      <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-x">
+    <path fill-rule="evenodd" d="M3.72 3.72a.75.75 0 011.06 0L8 6.94l3.22-3.22a.75.75 0 111.06 1.06L9.06 8l3.22 3.22a.75.75 0 11-1.06 1.06L8 9.06l-3.22 3.22a.75.75 0 01-1.06-1.06L6.94 8 3.72 4.78a.75.75 0 010-1.06z"></path>
+</svg>
+    </button>
+    
+      <div>{{ message }}</div>
+
+  </div>
+</div>
+  </template>
+</div>
+
+
+    
+
+  <include-fragment class="js-notification-shelf-include-fragment" data-base-src="https://github.com/notifications/beta/shelf"></include-fragment>
+
+
+
+
+
+  <div
+    class="application-main "
+    data-commit-hovercards-enabled
+    data-discussion-hovercards-enabled
+    data-issue-and-pr-hovercards-enabled
+  >
+        <div itemscope itemtype="http://schema.org/SoftwareSourceCode" class="">
+    <main id="js-repo-pjax-container" data-pjax-container >
+      
+
+    
+
+
+
+
+      <include-fragment src="/orgs/Glogobyte/survey_banner">
+    </include-fragment>
+
+
+
+  <div id="repository-container-header" class="pt-3 hide-full-screen mb-5" style="background-color: var(--color-page-header-bg);" data-pjax-replace>
+
+      <div class="d-flex mb-3 px-3 px-md-4 px-lg-5">
+
+        <div class="flex-auto min-width-0 width-fit mr-3">
+            <h1 class=" d-flex flex-wrap flex-items-center wb-break-word f3 text-normal">
+    <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-repo color-icon-secondary mr-2">
+    <path fill-rule="evenodd" d="M2 2.5A2.5 2.5 0 014.5 0h8.75a.75.75 0 01.75.75v12.5a.75.75 0 01-.75.75h-2.5a.75.75 0 110-1.5h1.75v-2h-8a1 1 0 00-.714 1.7.75.75 0 01-1.072 1.05A2.495 2.495 0 012 11.5v-9zm10.5-1V9h-8c-.356 0-.694.074-1 .208V2.5a1 1 0 011-1h8zM5 12.25v3.25a.25.25 0 00.4.2l1.45-1.087a.25.25 0 01.3 0L8.6 15.7a.25.25 0 00.4-.2v-3.25a.25.25 0 00-.25-.25h-3.5a.25.25 0 00-.25.25z"></path>
+</svg>
+  <span class="author flex-self-stretch" itemprop="author">
+    <a class="url fn" rel="author" data-hovercard-type="user" data-hovercard-url="/users/Glogobyte/hovercard" data-octo-click="hovercard-link-click" data-octo-dimensions="link_type:self" href="/Glogobyte">Glogobyte</a>
+  </span>
+  <span class="mx-1 flex-self-stretch color-text-secondary">/</span>
+  <strong itemprop="name" class="mr-2 flex-self-stretch">
+    <a data-pjax="#js-repo-pjax-container" href="/Glogobyte/isomiR_tools">isomiR_tools</a>
+  </strong>
+
+  <span></span><span class="Label Label--secondary v-align-middle mr-1">Public</span>
+</h1>
+
+        </div>
+
+          <ul class="pagehead-actions flex-shrink-0 d-none d-md-inline" style="padding: 2px 0;">
+
+  <li>
+      <a class="tooltipped tooltipped-s btn btn-sm" aria-label="You must be signed in to change notification settings" rel="nofollow" data-hydro-click="{&quot;event_type&quot;:&quot;authentication.click&quot;,&quot;payload&quot;:{&quot;location_in_page&quot;:&quot;notification subscription menu watch&quot;,&quot;repository_id&quot;:null,&quot;auth_type&quot;:&quot;LOG_IN&quot;,&quot;originating_url&quot;:&quot;https://github.com/Glogobyte/isomiR_tools/blob/main/README.md&quot;,&quot;user_id&quot;:null}}" data-hydro-click-hmac="8a1427e0c2e588020f78dcdc1c627d9b968cf8dcc1784c2b6debe73f693bcba6" href="/login?return_to=%2FGlogobyte%2FisomiR_tools">
+    <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-bell">
+    <path d="M8 16a2 2 0 001.985-1.75c.017-.137-.097-.25-.235-.25h-3.5c-.138 0-.252.113-.235.25A2 2 0 008 16z"></path><path fill-rule="evenodd" d="M8 1.5A3.5 3.5 0 004.5 5v2.947c0 .346-.102.683-.294.97l-1.703 2.556a.018.018 0 00-.003.01l.001.006c0 .002.002.004.004.006a.017.017 0 00.006.004l.007.001h10.964l.007-.001a.016.016 0 00.006-.004.016.016 0 00.004-.006l.001-.007a.017.017 0 00-.003-.01l-1.703-2.554a1.75 1.75 0 01-.294-.97V5A3.5 3.5 0 008 1.5zM3 5a5 5 0 0110 0v2.947c0 .05.015.098.042.139l1.703 2.555A1.518 1.518 0 0113.482 13H2.518a1.518 1.518 0 01-1.263-2.36l1.703-2.554A.25.25 0 003 7.947V5z"></path>
+</svg>
+    Notifications
+</a>
+  </li>
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+          <a class="btn btn-sm btn-with-count  tooltipped tooltipped-s" aria-label="You must be signed in to star a repository" rel="nofollow" data-hydro-click="{&quot;event_type&quot;:&quot;authentication.click&quot;,&quot;payload&quot;:{&quot;location_in_page&quot;:&quot;star button&quot;,&quot;repository_id&quot;:323269699,&quot;auth_type&quot;:&quot;LOG_IN&quot;,&quot;originating_url&quot;:&quot;https://github.com/Glogobyte/isomiR_tools/blob/main/README.md&quot;,&quot;user_id&quot;:null}}" data-hydro-click-hmac="8d7d6b826a32ef126a9e4d10300085e838ff2bfef122bb94d954537f5a83f4df" href="/login?return_to=%2FGlogobyte%2FisomiR_tools">
+      <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-star v-align-text-bottom mr-1">
+    <path fill-rule="evenodd" d="M8 .25a.75.75 0 01.673.418l1.882 3.815 4.21.612a.75.75 0 01.416 1.279l-3.046 2.97.719 4.192a.75.75 0 01-1.088.791L8 12.347l-3.766 1.98a.75.75 0 01-1.088-.79l.72-4.194L.818 6.374a.75.75 0 01.416-1.28l4.21-.611L7.327.668A.75.75 0 018 .25zm0 2.445L6.615 5.5a.75.75 0 01-.564.41l-3.097.45 2.24 2.184a.75.75 0 01.216.664l-.528 3.084 2.769-1.456a.75.75 0 01.698 0l2.77 1.456-.53-3.084a.75.75 0 01.216-.664l2.24-2.183-3.096-.45a.75.75 0 01-.564-.41L8 2.694v.001z"></path>
+</svg>
+      <span data-view-component="true">
+        Star
+</span></a>
+    <a class="social-count js-social-count" href="/Glogobyte/isomiR_tools/stargazers"
+      aria-label="0 users starred this repository">
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+        <a class="btn btn-sm btn-with-count tooltipped tooltipped-s" aria-label="You must be signed in to fork a repository" rel="nofollow" data-hydro-click="{&quot;event_type&quot;:&quot;authentication.click&quot;,&quot;payload&quot;:{&quot;location_in_page&quot;:&quot;repo details fork button&quot;,&quot;repository_id&quot;:323269699,&quot;auth_type&quot;:&quot;LOG_IN&quot;,&quot;originating_url&quot;:&quot;https://github.com/Glogobyte/isomiR_tools/blob/main/README.md&quot;,&quot;user_id&quot;:null}}" data-hydro-click-hmac="0da1214ca99b40c2ec3035e5eb2bb1b466a0fb2832eaa130300f6566d504e451" href="/login?return_to=%2FGlogobyte%2FisomiR_tools">
+          <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-repo-forked">
+    <path fill-rule="evenodd" d="M5 3.25a.75.75 0 11-1.5 0 .75.75 0 011.5 0zm0 2.122a2.25 2.25 0 10-1.5 0v.878A2.25 2.25 0 005.75 8.5h1.5v2.128a2.251 2.251 0 101.5 0V8.5h1.5a2.25 2.25 0 002.25-2.25v-.878a2.25 2.25 0 10-1.5 0v.878a.75.75 0 01-.75.75h-4.5A.75.75 0 015 6.25v-.878zm3.75 7.378a.75.75 0 11-1.5 0 .75.75 0 011.5 0zm3-8.75a.75.75 0 100-1.5.75.75 0 000 1.5z"></path>
+</svg>
+          Fork
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+      <a href="/Glogobyte/isomiR_tools/network/members" class="social-count"
+         aria-label="0 users forked this repository">
+        0
+      </a>
+  </li>
+
+  <li>
+    
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+</ul>
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+      <div id="responsive-meta-container" data-pjax-replace>
+</div>
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+<nav data-pjax="#js-repo-pjax-container" aria-label="Repository" data-view-component="true" class="js-repo-nav js-sidenav-container-pjax js-responsive-underlinenav overflow-hidden UnderlineNav px-3 px-md-4 px-lg-5">
+
+  <ul data-view-component="true" class="UnderlineNav-body list-style-none">
+      <li data-view-component="true" class="d-inline-flex">
+  <a id="code-tab" href="/Glogobyte/isomiR_tools" data-tab-item="i0code-tab" data-selected-links="repo_source repo_downloads repo_commits repo_releases repo_tags repo_branches repo_packages repo_deployments /Glogobyte/isomiR_tools" data-hotkey="g c" data-ga-click="Repository, Navigation click, Code tab" data-pjax="#repo-content-pjax-container" aria-current="page" data-view-component="true" class="UnderlineNav-item hx_underlinenav-item no-wrap js-responsive-underlinenav-item js-selected-navigation-item selected">
+    
+                  <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-code UnderlineNav-octicon d-none d-sm-inline">
+    <path fill-rule="evenodd" d="M4.72 3.22a.75.75 0 011.06 1.06L2.06 8l3.72 3.72a.75.75 0 11-1.06 1.06L.47 8.53a.75.75 0 010-1.06l4.25-4.25zm6.56 0a.75.75 0 10-1.06 1.06L13.94 8l-3.72 3.72a.75.75 0 101.06 1.06l4.25-4.25a.75.75 0 000-1.06l-4.25-4.25z"></path>
+</svg>
+          <span data-content="Code">Code</span>
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+
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+      <li data-view-component="true" class="d-inline-flex">
+  <a id="issues-tab" href="/Glogobyte/isomiR_tools/issues" data-tab-item="i1issues-tab" data-selected-links="repo_issues repo_labels repo_milestones /Glogobyte/isomiR_tools/issues" data-hotkey="g i" data-ga-click="Repository, Navigation click, Issues tab" data-pjax="#repo-content-pjax-container" data-view-component="true" class="UnderlineNav-item hx_underlinenav-item no-wrap js-responsive-underlinenav-item js-selected-navigation-item">
+    
+                  <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-issue-opened UnderlineNav-octicon d-none d-sm-inline">
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+</svg>
+          <span data-content="Issues">Issues</span>
+            <span title="1" data-view-component="true" class="Counter">1</span>
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+      <li data-view-component="true" class="d-inline-flex">
+  <a id="pull-requests-tab" href="/Glogobyte/isomiR_tools/pulls" data-tab-item="i2pull-requests-tab" data-selected-links="repo_pulls checks /Glogobyte/isomiR_tools/pulls" data-hotkey="g p" data-ga-click="Repository, Navigation click, Pull requests tab" data-pjax="#repo-content-pjax-container" data-view-component="true" class="UnderlineNav-item hx_underlinenav-item no-wrap js-responsive-underlinenav-item js-selected-navigation-item">
+    
+                  <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-git-pull-request UnderlineNav-octicon d-none d-sm-inline">
+    <path fill-rule="evenodd" d="M7.177 3.073L9.573.677A.25.25 0 0110 .854v4.792a.25.25 0 01-.427.177L7.177 3.427a.25.25 0 010-.354zM3.75 2.5a.75.75 0 100 1.5.75.75 0 000-1.5zm-2.25.75a2.25 2.25 0 113 2.122v5.256a2.251 2.251 0 11-1.5 0V5.372A2.25 2.25 0 011.5 3.25zM11 2.5h-1V4h1a1 1 0 011 1v5.628a2.251 2.251 0 101.5 0V5A2.5 2.5 0 0011 2.5zm1 10.25a.75.75 0 111.5 0 .75.75 0 01-1.5 0zM3.75 12a.75.75 0 100 1.5.75.75 0 000-1.5z"></path>
+</svg>
+          <span data-content="Pull requests">Pull requests</span>
+            <span title="0" hidden="hidden" data-view-component="true" class="Counter">0</span>
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+      <li data-view-component="true" class="d-inline-flex">
+  <a id="actions-tab" href="/Glogobyte/isomiR_tools/actions" data-tab-item="i3actions-tab" data-selected-links="repo_actions /Glogobyte/isomiR_tools/actions" data-hotkey="g a" data-ga-click="Repository, Navigation click, Actions tab" data-pjax="#repo-content-pjax-container" data-view-component="true" class="UnderlineNav-item hx_underlinenav-item no-wrap js-responsive-underlinenav-item js-selected-navigation-item">
+    
+                  <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-play UnderlineNav-octicon d-none d-sm-inline">
+    <path fill-rule="evenodd" d="M1.5 8a6.5 6.5 0 1113 0 6.5 6.5 0 01-13 0zM8 0a8 8 0 100 16A8 8 0 008 0zM6.379 5.227A.25.25 0 006 5.442v5.117a.25.25 0 00.379.214l4.264-2.559a.25.25 0 000-.428L6.379 5.227z"></path>
+</svg>
+          <span data-content="Actions">Actions</span>
+            <span title="Not available" data-view-component="true" class="Counter"></span>
+
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+      <li data-view-component="true" class="d-inline-flex">
+  <a id="projects-tab" href="/Glogobyte/isomiR_tools/projects" data-tab-item="i4projects-tab" data-selected-links="repo_projects new_repo_project repo_project /Glogobyte/isomiR_tools/projects" data-hotkey="g b" data-ga-click="Repository, Navigation click, Projects tab" data-view-component="true" class="UnderlineNav-item hx_underlinenav-item no-wrap js-responsive-underlinenav-item js-selected-navigation-item">
+    
+                  <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-project UnderlineNav-octicon d-none d-sm-inline">
+    <path fill-rule="evenodd" d="M1.75 0A1.75 1.75 0 000 1.75v12.5C0 15.216.784 16 1.75 16h12.5A1.75 1.75 0 0016 14.25V1.75A1.75 1.75 0 0014.25 0H1.75zM1.5 1.75a.25.25 0 01.25-.25h12.5a.25.25 0 01.25.25v12.5a.25.25 0 01-.25.25H1.75a.25.25 0 01-.25-.25V1.75zM11.75 3a.75.75 0 00-.75.75v7.5a.75.75 0 001.5 0v-7.5a.75.75 0 00-.75-.75zm-8.25.75a.75.75 0 011.5 0v5.5a.75.75 0 01-1.5 0v-5.5zM8 3a.75.75 0 00-.75.75v3.5a.75.75 0 001.5 0v-3.5A.75.75 0 008 3z"></path>
+</svg>
+          <span data-content="Projects">Projects</span>
+            <span title="0" hidden="hidden" data-view-component="true" class="Counter">0</span>
+
+    
+</a></li>
+      <li data-view-component="true" class="d-inline-flex">
+  <a id="wiki-tab" href="/Glogobyte/isomiR_tools/wiki" data-tab-item="i5wiki-tab" data-selected-links="repo_wiki /Glogobyte/isomiR_tools/wiki" data-hotkey="g w" data-ga-click="Repository, Navigation click, Wikis tab" data-view-component="true" class="UnderlineNav-item hx_underlinenav-item no-wrap js-responsive-underlinenav-item js-selected-navigation-item">
+    
+                  <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-book UnderlineNav-octicon d-none d-sm-inline">
+    <path fill-rule="evenodd" d="M0 1.75A.75.75 0 01.75 1h4.253c1.227 0 2.317.59 3 1.501A3.744 3.744 0 0111.006 1h4.245a.75.75 0 01.75.75v10.5a.75.75 0 01-.75.75h-4.507a2.25 2.25 0 00-1.591.659l-.622.621a.75.75 0 01-1.06 0l-.622-.621A2.25 2.25 0 005.258 13H.75a.75.75 0 01-.75-.75V1.75zm8.755 3a2.25 2.25 0 012.25-2.25H14.5v9h-3.757c-.71 0-1.4.201-1.992.572l.004-7.322zm-1.504 7.324l.004-5.073-.002-2.253A2.25 2.25 0 005.003 2.5H1.5v9h3.757a3.75 3.75 0 011.994.574z"></path>
+</svg>
+          <span data-content="Wiki">Wiki</span>
+            <span title="Not available" data-view-component="true" class="Counter"></span>
+
+    
+</a></li>
+      <li data-view-component="true" class="d-inline-flex">
+  <a id="security-tab" href="/Glogobyte/isomiR_tools/security" data-tab-item="i6security-tab" data-selected-links="security overview alerts policy token_scanning code_scanning /Glogobyte/isomiR_tools/security" data-hotkey="g s" data-ga-click="Repository, Navigation click, Security tab" data-pjax="#repo-content-pjax-container" data-view-component="true" class="UnderlineNav-item hx_underlinenav-item no-wrap js-responsive-underlinenav-item js-selected-navigation-item">
+    
+                  <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-shield UnderlineNav-octicon d-none d-sm-inline">
+    <path fill-rule="evenodd" d="M7.467.133a1.75 1.75 0 011.066 0l5.25 1.68A1.75 1.75 0 0115 3.48V7c0 1.566-.32 3.182-1.303 4.682-.983 1.498-2.585 2.813-5.032 3.855a1.7 1.7 0 01-1.33 0c-2.447-1.042-4.049-2.357-5.032-3.855C1.32 10.182 1 8.566 1 7V3.48a1.75 1.75 0 011.217-1.667l5.25-1.68zm.61 1.429a.25.25 0 00-.153 0l-5.25 1.68a.25.25 0 00-.174.238V7c0 1.358.275 2.666 1.057 3.86.784 1.194 2.121 2.34 4.366 3.297a.2.2 0 00.154 0c2.245-.956 3.582-2.104 4.366-3.298C13.225 9.666 13.5 8.36 13.5 7V3.48a.25.25 0 00-.174-.237l-5.25-1.68zM9 10.5a1 1 0 11-2 0 1 1 0 012 0zm-.25-5.75a.75.75 0 10-1.5 0v3a.75.75 0 001.5 0v-3z"></path>
+</svg>
+          <span data-content="Security">Security</span>
+            <include-fragment src="/Glogobyte/isomiR_tools/security/overall-count" accept="text/fragment+html"></include-fragment>
+
+    
+</a></li>
+      <li data-view-component="true" class="d-inline-flex">
+  <a id="insights-tab" href="/Glogobyte/isomiR_tools/pulse" data-tab-item="i7insights-tab" data-selected-links="repo_graphs repo_contributors dependency_graph dependabot_updates pulse people community /Glogobyte/isomiR_tools/pulse" data-ga-click="Repository, Navigation click, Insights tab" data-view-component="true" class="UnderlineNav-item hx_underlinenav-item no-wrap js-responsive-underlinenav-item js-selected-navigation-item">
+    
+                  <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-graph UnderlineNav-octicon d-none d-sm-inline">
+    <path fill-rule="evenodd" d="M1.5 1.75a.75.75 0 00-1.5 0v12.5c0 .414.336.75.75.75h14.5a.75.75 0 000-1.5H1.5V1.75zm14.28 2.53a.75.75 0 00-1.06-1.06L10 7.94 7.53 5.47a.75.75 0 00-1.06 0L3.22 8.72a.75.75 0 001.06 1.06L7 7.06l2.47 2.47a.75.75 0 001.06 0l5.25-5.25z"></path>
+</svg>
+          <span data-content="Insights">Insights</span>
+            <span title="Not available" data-view-component="true" class="Counter"></span>
+
+    
+</a></li>
+</ul>
+    <div style="visibility:hidden;" data-view-component="true" class="UnderlineNav-actions js-responsive-underlinenav-overflow position-absolute pr-3 pr-md-4 pr-lg-5 right-0">      <details data-view-component="true" class="details-overlay details-reset position-relative">
+  <summary role="button" data-view-component="true">          <div class="UnderlineNav-item mr-0 border-0">
+            <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-kebab-horizontal">
+    <path d="M8 9a1.5 1.5 0 100-3 1.5 1.5 0 000 3zM1.5 9a1.5 1.5 0 100-3 1.5 1.5 0 000 3zm13 0a1.5 1.5 0 100-3 1.5 1.5 0 000 3z"></path>
+</svg>
+            <span class="sr-only">More</span>
+          </div>
+</summary>
+  <div data-view-component="true">          <details-menu role="menu" data-view-component="true" class="dropdown-menu dropdown-menu-sw">
+  
+            <ul>
+                <li data-menu-item="i0code-tab" hidden>
+                  <a role="menuitem" class="js-selected-navigation-item selected dropdown-item" aria-current="page" data-selected-links="repo_source repo_downloads repo_commits repo_releases repo_tags repo_branches repo_packages repo_deployments /Glogobyte/isomiR_tools" href="/Glogobyte/isomiR_tools">
+                    Code
+</a>                </li>
+                <li data-menu-item="i1issues-tab" hidden>
+                  <a role="menuitem" class="js-selected-navigation-item dropdown-item" data-selected-links="repo_issues repo_labels repo_milestones /Glogobyte/isomiR_tools/issues" href="/Glogobyte/isomiR_tools/issues">
+                    Issues
+</a>                </li>
+                <li data-menu-item="i2pull-requests-tab" hidden>
+                  <a role="menuitem" class="js-selected-navigation-item dropdown-item" data-selected-links="repo_pulls checks /Glogobyte/isomiR_tools/pulls" href="/Glogobyte/isomiR_tools/pulls">
+                    Pull requests
+</a>                </li>
+                <li data-menu-item="i3actions-tab" hidden>
+                  <a role="menuitem" class="js-selected-navigation-item dropdown-item" data-selected-links="repo_actions /Glogobyte/isomiR_tools/actions" href="/Glogobyte/isomiR_tools/actions">
+                    Actions
+</a>                </li>
+                <li data-menu-item="i4projects-tab" hidden>
+                  <a role="menuitem" class="js-selected-navigation-item dropdown-item" data-selected-links="repo_projects new_repo_project repo_project /Glogobyte/isomiR_tools/projects" href="/Glogobyte/isomiR_tools/projects">
+                    Projects
+</a>                </li>
+                <li data-menu-item="i5wiki-tab" hidden>
+                  <a role="menuitem" class="js-selected-navigation-item dropdown-item" data-selected-links="repo_wiki /Glogobyte/isomiR_tools/wiki" href="/Glogobyte/isomiR_tools/wiki">
+                    Wiki
+</a>                </li>
+                <li data-menu-item="i6security-tab" hidden>
+                  <a role="menuitem" class="js-selected-navigation-item dropdown-item" data-selected-links="security overview alerts policy token_scanning code_scanning /Glogobyte/isomiR_tools/security" href="/Glogobyte/isomiR_tools/security">
+                    Security
+</a>                </li>
+                <li data-menu-item="i7insights-tab" hidden>
+                  <a role="menuitem" class="js-selected-navigation-item dropdown-item" data-selected-links="repo_graphs repo_contributors dependency_graph dependabot_updates pulse people community /Glogobyte/isomiR_tools/pulse" href="/Glogobyte/isomiR_tools/pulse">
+                    Insights
+</a>                </li>
+            </ul>
+
+</details-menu></div>
+</details></div>
+</nav>
+  </div>
+
+
+
+<div class="clearfix new-discussion-timeline container-xl px-3 px-md-4 px-lg-5">
+  <div id="repo-content-pjax-container" class="repository-content " >
+
+    
+
+
+    
+      
+  
+  
+<div>
+  
+
+
+    <a class="d-none js-permalink-shortcut" data-hotkey="y" href="/Glogobyte/isomiR_tools/blob/9a13fbd2e9b9f2cfaa39d2d3ddd7b2adf56423b7/README.md">Permalink</a>
+
+    <!-- blob contrib key: blob_contributors:v22:c4cbefb7ca27cf1a82546757c5d7de2981dd87d89247bf82ea33cf3ecbd8367c -->
+
+    <div class="d-flex flex-items-start flex-shrink-0 pb-3 flex-wrap flex-md-nowrap flex-justify-between flex-md-justify-start">
+      
+<div class="position-relative">
+  <details class="details-reset details-overlay mr-0 mb-0 " id="branch-select-menu">
+    <summary class="btn css-truncate"
+            data-hotkey="w"
+            title="Switch branches or tags">
+      <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-git-branch">
+    <path fill-rule="evenodd" d="M11.75 2.5a.75.75 0 100 1.5.75.75 0 000-1.5zm-2.25.75a2.25 2.25 0 113 2.122V6A2.5 2.5 0 0110 8.5H6a1 1 0 00-1 1v1.128a2.251 2.251 0 11-1.5 0V5.372a2.25 2.25 0 111.5 0v1.836A2.492 2.492 0 016 7h4a1 1 0 001-1v-.628A2.25 2.25 0 019.5 3.25zM4.25 12a.75.75 0 100 1.5.75.75 0 000-1.5zM3.5 3.25a.75.75 0 111.5 0 .75.75 0 01-1.5 0z"></path>
+</svg>
+      <span class="css-truncate-target" data-menu-button>main</span>
+      <span class="dropdown-caret"></span>
+    </summary>
+
+      
+<div class="SelectMenu">
+  <div class="SelectMenu-modal">
+    <header class="SelectMenu-header">
+      <span class="SelectMenu-title">Switch branches/tags</span>
+      <button class="SelectMenu-closeButton" type="button" data-toggle-for="branch-select-menu"><svg aria-label="Close menu" aria-hidden="false" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-x">
+    <path fill-rule="evenodd" d="M3.72 3.72a.75.75 0 011.06 0L8 6.94l3.22-3.22a.75.75 0 111.06 1.06L9.06 8l3.22 3.22a.75.75 0 11-1.06 1.06L8 9.06l-3.22 3.22a.75.75 0 01-1.06-1.06L6.94 8 3.72 4.78a.75.75 0 010-1.06z"></path>
+</svg></button>
+    </header>
+
+    <input-demux data-action="tab-container-change:input-demux#storeInput tab-container-changed:input-demux#updateInput">
+      <tab-container class="d-flex flex-column js-branches-tags-tabs" style="min-height: 0;">
+        <div class="SelectMenu-filter">
+          <input data-target="input-demux.source"
+                 id="context-commitish-filter-field"
+                 class="SelectMenu-input form-control"
+                 aria-owns="ref-list-branches"
+                 data-controls-ref-menu-id="ref-list-branches"
+                 autofocus
+                 autocomplete="off"
+                 aria-label="Filter branches/tags"
+                 placeholder="Filter branches/tags"
+                 type="text"
+          >
+        </div>
+
+        <div class="SelectMenu-tabs" role="tablist" data-target="input-demux.control" >
+          <button class="SelectMenu-tab" type="button" role="tab" aria-selected="true">Branches</button>
+          <button class="SelectMenu-tab" type="button" role="tab">Tags</button>
+        </div>
+
+        <div role="tabpanel" id="ref-list-branches" data-filter-placeholder="Filter branches/tags" class="d-flex flex-column flex-auto overflow-auto" tabindex="">
+          <ref-selector
+            type="branch"
+            data-targets="input-demux.sinks"
+            data-action="
+              input-entered:ref-selector#inputEntered
+              tab-selected:ref-selector#tabSelected
+              focus-list:ref-selector#focusFirstListMember
+            "
+            query-endpoint="/Glogobyte/isomiR_tools/refs"
+            
+            cache-key="v0:1608537841.0"
+            current-committish="bWFpbg=="
+            default-branch="bWFpbg=="
+            name-with-owner="R2xvZ29ieXRlL2lzb21pUl90b29scw=="
+            prefetch-on-mouseover
+          >
+
+            <template data-target="ref-selector.fetchFailedTemplate">
+              <div class="SelectMenu-message" data-index="{{ index }}">Could not load branches</div>
+            </template>
+
+              <template data-target="ref-selector.noMatchTemplate">
+    <div class="SelectMenu-message">Nothing to show</div>
+</template>
+
+
+            <!-- TODO: this max-height is necessary or else the branch list won't scroll.  why? -->
+            <div data-target="ref-selector.listContainer" role="menu" class="SelectMenu-list " style="max-height: 330px" data-pjax="#repo-content-pjax-container">
+              <div class="SelectMenu-loading pt-3 pb-0" aria-label="Menu is loading">
+                <svg style="box-sizing: content-box; color: var(--color-icon-primary);" width="32" height="32" viewBox="0 0 16 16" fill="none" data-view-component="true" class="anim-rotate">
+  <circle cx="8" cy="8" r="7" stroke="currentColor" stroke-opacity="0.25" stroke-width="2" vector-effect="non-scaling-stroke" />
+  <path d="M15 8a7.002 7.002 0 00-7-7" stroke="currentColor" stroke-width="2" stroke-linecap="round" vector-effect="non-scaling-stroke" />
+</svg>
+              </div>
+            </div>
+
+              <template data-target="ref-selector.itemTemplate">
+  <a href="https://github.com/Glogobyte/isomiR_tools/blob/{{ urlEncodedRefName }}/README.md" class="SelectMenu-item" role="menuitemradio" rel="nofollow" aria-checked="{{ isCurrent }}" data-index="{{ index }}">
+    <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-check SelectMenu-icon SelectMenu-icon--check">
+    <path fill-rule="evenodd" d="M13.78 4.22a.75.75 0 010 1.06l-7.25 7.25a.75.75 0 01-1.06 0L2.22 9.28a.75.75 0 011.06-1.06L6 10.94l6.72-6.72a.75.75 0 011.06 0z"></path>
+</svg>
+    <span class="flex-1 css-truncate css-truncate-overflow {{ isFilteringClass }}">{{ refName }}</span>
+    <span hidden="{{ isNotDefault }}" class="Label Label--secondary flex-self-start">default</span>
+  </a>
+</template>
+
+
+              <footer class="SelectMenu-footer"><a href="/Glogobyte/isomiR_tools/branches">View all branches</a></footer>
+          </ref-selector>
+
+        </div>
+
+        <div role="tabpanel" id="tags-menu" data-filter-placeholder="Find a tag" class="d-flex flex-column flex-auto overflow-auto" tabindex="" hidden>
+          <ref-selector
+            type="tag"
+            data-action="
+              input-entered:ref-selector#inputEntered
+              tab-selected:ref-selector#tabSelected
+              focus-list:ref-selector#focusFirstListMember
+            "
+            data-targets="input-demux.sinks"
+            query-endpoint="/Glogobyte/isomiR_tools/refs"
+            cache-key="v0:1608537841.0"
+            current-committish="bWFpbg=="
+            default-branch="bWFpbg=="
+            name-with-owner="R2xvZ29ieXRlL2lzb21pUl90b29scw=="
+          >
+
+            <template data-target="ref-selector.fetchFailedTemplate">
+              <div class="SelectMenu-message" data-index="{{ index }}">Could not load tags</div>
+            </template>
+
+            <template data-target="ref-selector.noMatchTemplate">
+              <div class="SelectMenu-message" data-index="{{ index }}">Nothing to show</div>
+            </template>
+
+              <template data-target="ref-selector.itemTemplate">
+  <a href="https://github.com/Glogobyte/isomiR_tools/blob/{{ urlEncodedRefName }}/README.md" class="SelectMenu-item" role="menuitemradio" rel="nofollow" aria-checked="{{ isCurrent }}" data-index="{{ index }}">
+    <svg aria-hidden="true" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-check SelectMenu-icon SelectMenu-icon--check">
+    <path fill-rule="evenodd" d="M13.78 4.22a.75.75 0 010 1.06l-7.25 7.25a.75.75 0 01-1.06 0L2.22 9.28a.75.75 0 011.06-1.06L6 10.94l6.72-6.72a.75.75 0 011.06 0z"></path>
+</svg>
+    <span class="flex-1 css-truncate css-truncate-overflow {{ isFilteringClass }}">{{ refName }}</span>
+    <span hidden="{{ isNotDefault }}" class="Label Label--secondary flex-self-start">default</span>
+  </a>
+</template>
+
+
+            <div data-target="ref-selector.listContainer" role="menu" class="SelectMenu-list" style="max-height: 330px" data-pjax="#repo-content-pjax-container">
+              <div class="SelectMenu-loading pt-3 pb-0" aria-label="Menu is loading">
+                <svg style="box-sizing: content-box; color: var(--color-icon-primary);" width="32" height="32" viewBox="0 0 16 16" fill="none" data-view-component="true" class="anim-rotate">
+  <circle cx="8" cy="8" r="7" stroke="currentColor" stroke-opacity="0.25" stroke-width="2" vector-effect="non-scaling-stroke" />
+  <path d="M15 8a7.002 7.002 0 00-7-7" stroke="currentColor" stroke-width="2" stroke-linecap="round" vector-effect="non-scaling-stroke" />
+</svg>
+              </div>
+            </div>
+              <footer class="SelectMenu-footer"><a href="/Glogobyte/isomiR_tools/tags">View all tags</a></footer>
+          </ref-selector>
+        </div>
+      </tab-container>
+    </input-demux>
+  </div>
+</div>
+
+  </details>
+
+</div>
+
+      <h2 id="blob-path" class="breadcrumb flex-auto flex-self-center min-width-0 text-normal mx-2 width-full width-md-auto flex-order-1 flex-md-order-none mt-3 mt-md-0">
+        <span class="js-repo-root text-bold"><span class="js-path-segment d-inline-block wb-break-all"><a data-pjax="#repo-content-pjax-container" href="/Glogobyte/isomiR_tools"><span>isomiR_tools</span></a></span></span><span class="separator">/</span><strong class="final-path">README.md</strong>
+      </h2>
+      <a href="/Glogobyte/isomiR_tools/find/main"
+            class="js-pjax-capture-input btn mr-2 d-none d-md-block"
+            data-pjax
+            data-hotkey="t">
+        Go to file
+      </a>
+
+      <details id="blob-more-options-details" data-view-component="true" class="details-overlay details-reset position-relative">
+  <summary role="button" data-view-component="true" class="btn">
+  
+            <svg aria-label="More options" role="img" height="16" viewBox="0 0 16 16" version="1.1" width="16" data-view-component="true" class="octicon octicon-kebab-horizontal">
+    <path d="M8 9a1.5 1.5 0 100-3 1.5 1.5 0 000 3zM1.5 9a1.5 1.5 0 100-3 1.5 1.5 0 000 3zm13 0a1.5 1.5 0 100-3 1.5 1.5 0 000 3z"></path>
+</svg>
+
+  
+
+</summary>
+  <div data-view-component="true">          <ul class="dropdown-menu dropdown-menu-sw">
+            <li class="d-block d-md-none">
+              <a class="dropdown-item d-flex flex-items-baseline" data-hydro-click="{&quot;event_type&quot;:&quot;repository.click&quot;,&quot;payload&quot;:{&quot;target&quot;:&quot;FIND_FILE_BUTTON&quot;,&quot;repository_id&quot;:323269699,&quot;originating_url&quot;:&quot;https://github.com/Glogobyte/isomiR_tools/blob/main/README.md&quot;,&quot;user_id&quot;:null}}" data-hydro-click-hmac="0967f838d23804cca91cf836ae397b8423828a55f6669275f803f1964c55889b" data-ga-click="Repository, find file, location:repo overview" data-hotkey="t" data-pjax="true" href="/Glogobyte/isomiR_tools/find/main">
+                <span class="flex-auto">Go to file</span>
+                <span class="text-small color-text-secondary" aria-hidden="true">T</span>
+</a>            </li>
+            <li data-toggle-for="blob-more-options-details">
+              <button data-toggle-for="jumpto-line-details-dialog" type="button" data-view-component="true" class="dropdown-item btn-link">
+  
+  
+                <span class="d-flex flex-items-baseline">
+                  <span class="flex-auto">Go to line</span>
+                  <span class="text-small color-text-secondary" aria-hidden="true">L</span>
+                </span>
+
+  
+
+</button>            </li>
+            <li class="dropdown-divider" role="none"></li>
+            <li>
+              <clipboard-copy data-toggle-for="blob-more-options-details" aria-label="Copy path" value="README.md" data-view-component="true" class="dropdown-item cursor-pointer">
+    
+                Copy path
+
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+    <article class="markdown-body entry-content container-lg" itemprop="text"><h2><a id="user-content-isomir-tools" class="anchor" aria-hidden="true" href="#isomir-tools"><svg class="octicon octicon-link" viewBox="0 0 16 16" version="1.1" width="16" height="16" aria-hidden="true"><path fill-rule="evenodd" d="M7.775 3.275a.75.75 0 001.06 1.06l1.25-1.25a2 2 0 112.83 2.83l-2.5 2.5a2 2 0 01-2.83 0 .75.75 0 00-1.06 1.06 3.5 3.5 0 004.95 0l2.5-2.5a3.5 3.5 0 00-4.95-4.95l-1.25 1.25zm-4.69 9.64a2 2 0 010-2.83l2.5-2.5a2 2 0 012.83 0 .75.75 0 001.06-1.06 3.5 3.5 0 00-4.95 0l-2.5 2.5a3.5 3.5 0 004.95 4.95l1.25-1.25a.75.75 0 00-1.06-1.06l-1.25 1.25a2 2 0 01-2.83 0z"></path></svg></a>isomiR tools</h2>
+<p>List of tools updated 01.01.2021</p>
+<table>
+<thead>
+<tr>
+<th align="center">Tool name</th>
+<th align="center">Type</th>
+<th>Tool Features</th>
+<th align="center">Year</th>
+<th align="center">Authors</th>
+<th align="center">Journal<br>URL<br>Reference<br>(DOI number)</th>
+</tr>
+</thead>
+<tbody>
+<tr>
+<td align="center">miRMaster</td>
+<td align="center">Web</td>
+<td>● Quantification of miRNAs and non-coding RNAs<br>● Discovering of new miRNAs and isomiRs<br>● Discovering of new miRNAs and isomiRs<br>● Quantification on known and novel miRNA with miRDeep2<br>● Preprocessing (adapter trimming, quality filtering, read collapsing)<br>● Mapping with Bowtie to various ncRNA (rRNAs, snRNAs, snoRNAs, scaRNAs, lincRNAs, piRNAs, tRNAs)<br>● Exogenous miRNAs mapping with bacteria and viruses<br>● Used for validation used samples from lung and blood samples from PAX blood RNA pool</td>
+<td align="center">2017</td>
+<td align="center">Tobias Fehlmann et all.</td>
+<td align="center">Nucleic Acids Research<br><br>Open Access<br><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587802/" rel="nofollow">[URL]</a><br><br>10.1093/nar/ gkx595</td>
+</tr>
+<tr>
+<td align="center">QuickMIRSeq</td>
+<td align="center">Linux</td>
+<td>● Quantify miRNAs and isomiRs<br>● Avoid of multiple mapping issue of reads of identical sequences<br>● Clustering and grouping of identical and similar sequences<br>● Trimming adapters, collapsing, joint mapping with Bowtie<br>● Remapping reads with mismatches to a reference genome to further reduce the number of false hits</td>
+<td align="center">2017</td>
+<td align="center">Shanrong Zhao et all.</td>
+<td align="center">BMC Bioinformatics<br><br>Open Access<br><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359966/" rel="nofollow">[URL]</a><br><br>10.1186/s12859 -017-1601-4</td>
+</tr>
+<tr>
+<td align="center">iMir</td>
+<td align="center">Linux<br>Mac</td>
+<td>● Identification of miRNAs and other sncRNAs, such as piRNAs<br>● Adapter trimming, quality filtering, differential expression analysis<br>● Analysis of sncRNAs and novel miRNAs<br>● Identification of isomirs using miRanalyzer<br>● Using miRAnalyzer and miRDeep2<br>● Statistical analysis to remove low expressed sncRNAs<br>● Differential Expression using Deseq Quantile normalization<br>● Target Prediction using TargetScan and miRanda</td>
+<td align="center">2013</td>
+<td align="center">Giorgio Giurato et all.</td>
+<td align="center">BMC<br>Bioinformatics<br><br>Open access<br><br><a href="https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-14-362" rel="nofollow">[URL]</a><br><br>10.1186/1471 -2105-14-362</td>
+</tr>
+<tr>
+<td align="center">MIR-isomiRExp</td>
+<td align="center">Web</td>
+<td>● Analyze the expression patterns or miRNA/isomer levels<br>● miRNA maturation and processing mechanism at isomiRs levels<br>● Using MirBase DB, mapping with Bowtie<br>● Differential expression using Deseq<br>● Analysis at the isomiR levels based/independent on miRNA locus<br>● Arm-switching analysis</td>
+<td align="center">2016</td>
+<td align="center">Li Guo et all.</td>
+<td align="center">Nature<br><br>Open Access<br><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806314/" rel="nofollow">[URL]</a><br><br>10.1038/ srep23700</td>
+</tr>
+<tr>
+<td align="center">miRNAgFree</td>
+<td align="center">Linux<br>Windows</td>
+<td>● miRNA prediction based on biogenesis features (known 5’ homogeneity) and isomiR duplex forming<br>● Uses the sRNAbench preprocessing</td>
+<td align="center">2017</td>
+<td align="center">EL Aparicio et all.</td>
+<td align="center">BioRxiv<br><br><a href="https://www.biorxiv.org/content/10.1101/193094v1.full" rel="nofollow">[URL]</a><br><br>10.1101/193094</td>
+</tr>
+<tr>
+<td align="center">isomiRID</td>
+<td align="center">Linux<br>Mac</td>
+<td>● Identification of 5’, 3’ and polymorphic isomiRs<br>● Identification of non-templated 5’ or 3’ end and variations<br>● It could be applied to every organism (plants + animals)<br>● Detection of isomiRs with one mismatch<br>● Mapping in pre-miRNAs with Bowtie</td>
+<td align="center">2013</td>
+<td align="center">Luiz Felipe Valter de Oliveira et all.</td>
+<td align="center">Bioinformatics<br><br><a href="https://academic.oup.com/bioinformatics/article/29/20/2521/276800" rel="nofollow">[URL]</a><br><br>10.1093/ bioinformatics/ btt424</td>
+</tr>
+<tr>
+<td align="center">MIRPIPE</td>
+<td align="center">Web</td>
+<td>● Rapid and simple browser-based miRNA homology detection and quantification of miRNAs<br>● Read counts from isomiRs of the same miRNA are combined. <br>● Using FASTX-tollkit, Cutadapt, BLASTN</td>
+<td align="center">2014</td>
+<td align="center">Carsten Kuenne et all.</td>
+<td align="center">Bioinformatics<br><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816158/" rel="nofollow">[URL]</a><br><br>10.1093/ bioinformatics/ btu573</td>
+</tr>
+<tr>
+<td align="center">CASMIR</td>
+<td align="center">Standalone<br>Linux</td>
+<td>● Sequence-oriented isomiR annotation which allows unbiased identification of global isomiRs from small sequencing data<br>● Alignment against canonical and precursors from miRBase<br>● Discovering of canonical, 5’, 3’, polymorphic, mixed type, non-templated isomiRs, quantification using miRDeep2<br>● In-house trimming and size filtering<br>● BLAST with in house custom isomiR-BLAST alignment tool<br>● Differential expression performed with a Poisson regression model combined with a quasi-likelihood approach and AUC based on methods of DeLong and Clarke-Pearson</td>
+<td align="center">2018</td>
+<td align="center">Chung Wah Wu et all.</td>
+<td align="center">BMC Genomics<br><br>Open Access<br><br><a href="https://www.ncbi.nlm.nih.gov/pubmed/29801434" rel="nofollow">[URL]</a><br><br>10.1186/s1286 4-018-4794-7</td>
+</tr>
+<tr>
+<td align="center">IsomiR-SEA</td>
+<td align="center">Linux<br>Windows<br>Mac</td>
+<td>● Provide users with a complete and accurate picture of the miRNAs, isomiRs and conserved miRNA:mRNA interaction sites <br>● Provide accurate miRNA and isomiRs expression levels<br>● Use a specialized algorithm for alignment<br>● Evaluates the positions of the encountered mismatches in analyzed tags</td>
+<td align="center">2016</td>
+<td align="center">Gianvito Urgese et all.</td>
+<td align="center">BMC Bioinformatics<br><br><a href="https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-016-0958-0" rel="nofollow">[URL]</a><br><br>10.1186/s12859 -016-0958-0</td>
+</tr>
+<tr>
+<td align="center">DeAnnIso</td>
+<td align="center">Web</td>
+<td>● Detection and Annotation of IsomiRs from sRNA se- quencing data<br>● Еxtract the differentially expressing isomiRs with isomiRs expression, isomiRs classification  from paired or multiple samples<br>● Tissue specific isomiR expression<br>● Using Bowtie and BLAST with miRBase<br>● Normalization with RPM<br>● isomiRs’ classification, 5’ isomiRs, 3’ isomiRs, isomiRs with internal modifications, templated and non-templated <br>● Target analysis and enrichment analysis of isomiRs with miRanda or RNA hybrid</td>
+<td align="center">2016</td>
+<td align="center">Yuanwei Zhang et all.</td>
+<td align="center">Nucleic Acids Research<br><br><a href="https://www.ncbi.nlm.nih.gov/pubmed/27179030" rel="nofollow">[URL]</a><br><br>10.1093/nar/ gkw427</td>
+</tr>
+<tr>
+<td align="center">IsomiRage</td>
+<td align="center">Windows<br>Mac</td>
+<td>● Identification of miRNA variants (canonical miRNAs, templated and non-templated isomiRs)<br>● Detects and groups all 3’-,5’- and trimmed variants <br>● Uses reference sequences from miRBase<br>● Classification of isomiRs according to the type of modification (uridylation, adenylation,etc)<br>● Mapping performed with Bowtie with no mismatches to reference and custom genome<br>● Normalization with RPM and read counts that can be used for comparisons of fold changes and other downstream analyses</td>
+<td align="center">2014</td>
+<td align="center">Muller Heiko et all.</td>
+<td align="center">Frontiers in Bioengineering and Biotechnology<br><br><a href="https://www.frontiersin.org/articles/10.3389/fbioe.2014.00038/full" rel="nofollow">[URL]</a><br><br>10.3389/fbioe. 2014.00038</td>
+</tr>
+<tr>
+<td align="center">QuagmiR</td>
+<td align="center">Standalone<br>Web</td>
+<td>● Designed for the detection and annotation of heterogeneous isomiRs<br>● Provide extensive customization of the process and reference databases according to user’s diverse research needs<br>● Can be used to analyze both private datasets and the public datasets that are available to authorized researchers through the CGC</td>
+<td align="center">2018</td>
+<td align="center">Xavier Bofill-De Ros et all.</td>
+<td align="center">Bioimformatics<br><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499244/" rel="nofollow">[URL]</a><br><br>10.1093/ bioinformatics/ bty843</td>
+</tr>
+<tr>
+<td align="center">Jasmine</td>
+<td align="center">R + Java</td>
+<td>● Identification of isomiR populations.<br>● Propose a comprehensive isomiR nomenclature<br>● Uses curated miRBase annotation.<br>● Adapter trimming (trimmomatic, cutadapt)<br>● Collapsing trimmed reads (fastx_collapser, fastq _to_fasta from FASTX-toolkit), Quality control (FastQC)<br>● Mapping with Bowtie with at least one mismatch<br>● Uses miRBase database</td>
+<td align="center">2019</td>
+<td align="center">Xiangfu Zhong et all.</td>
+<td align="center">Bioinformatics<br><br><a href="https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btz806/5612093" rel="nofollow">[URL]</a><br><br>10.1093/ bioinformatics/ btz806</td>
+</tr>
+<tr>
+<td align="center">CBS-miRSeq</td>
+<td align="center">Linux<br>Docker<br>VM</td>
+<td>● Color-spaced raw reads<br>● Read length distribution, summary of adapter removal, mapping statistics, and raw expression count matrix of known miRNAs.<br>● Using Bowtie with reference genome<br>● Differential expression analysis using Deseq2, EdgeR<br>● Identifies isomiRs using miRspring<br>● Predicts novel miRNA candidates using miRDeep2<br>● Predicts the most consistent miRNA:mRNA unique pairs, using RNAhybrid, miRanda</td>
+<td align="center">2019</td>
+<td align="center">Rupesh K. Kesharwani et all.</td>
+<td align="center">Computers in Biology and Medicine<br><br><a href="https://www.sciencedirect.com/science/article/pii/S001048251930188X" rel="nofollow">[URL]</a><br><br>10.1016/ j.compbiomed. 2019.05.019.</td>
+</tr>
+<tr>
+<td align="center">sRNAtoolbox</td>
+<td align="center">Web</td>
+<td>●Expression profiling of small RNAs, prediction of novel microRNAs, analysis of isomiRs<br>● Differential expression using DESeq, edgeR, and NOISeq<br>● Target prediction onuser-provided input data based on Miranda, PITA and TargetSpy<br>● Visualization of sRNA expression data in a genome context using jBrowse</td>
+<td align="center">2015</td>
+<td align="center">Antonio Rueda et all.</td>
+<td align="center">Nucleic Acids Research<br><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489306/pdf/gkv555.pdf" rel="nofollow">[URL]</a><br><br>10.1093/nar/ gkv555</td>
+</tr>
+<tr>
+<td align="center">sRNAnalyzer</td>
+<td align="center">Web</td>
+<td>● miRNA profiling strategies for isomiRs<br>● Detection of potential SNPs in miRNAs<br>● Uses Cutadapt, Printseq, FastX for preprocessing and Bowtie for mapping; MirBase and MirGen DB<br>● Use of LPM (local probability mapping) strategy to increase mapping specificity<br>● Extensive rRNA and tRNA filtering steps to enhance the accuracy of exogenous RNA mapping<br>● Exogenous RNA mapping process using sRNAnalyzer</td>
+<td align="center">2017</td>
+<td align="center">Xiaogang Wu et all.</td>
+<td align="center">Nucleic Acids Research<br><br>Open Access<br><br><a href="https://www.ncbi.nlm.nih.gov/pubmed/29069500" rel="nofollow">[URL]</a><br><br>10.1093/nar/ gkx999</td>
+</tr>
+<tr>
+<td align="center">mirPRo</td>
+<td align="center">Linux</td>
+<td>● Quantify known miRNAs<br>● Predict novel miRNAs and miRNA family expression quantification<br>● IsomiRs identification and categorization<br>● Arm switching detection<br>● Using Novoalign, HTSeq and pre-miRNAs from miRBase<br>● Using DESeq to perform differential expression profile analysis for known and novel mature miRNAs</td>
+<td align="center">2015</td>
+<td align="center">Jieming Shi et all.</td>
+<td align="center">Nature<br><br>Open Access<br><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592965/" rel="nofollow">[URL]</a><br><br>10.1038/ srep14617</td>
+</tr>
+<tr>
+<td align="center">miRge</td>
+<td align="center">Standalone</td>
+<td>● MirGeneDB miRNAs were used to assemble positive clusters (known miRNAs and  tRNA, snoRNA, rRNA or mRNA were used to assemble negative clusters (known non-miRNAs)<br>● Identification of isomiRs<br>● Novel miRNA detection <br>● Preprocessing with Cutadapt and mapping (Bowtie)<br>● Using miRbase and miRGen DB<br>● Detection of A-to-I editing</td>
+<td align="center">2015</td>
+<td align="center">Alexander S. Baras et all.</td>
+<td align="center">Plos one<br><br>Open Access<br><br><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143066" rel="nofollow">[URL]</a><br><br>10.1371/journal. pone.0143066</td>
+</tr>
+<tr>
+<td align="center">miRDis</td>
+<td align="center">Web</td>
+<td>● Systematic annotation of known miRNAs and other noncoding RNAs based on read mapped regions <br>● Prediction of novel miRNAs and noncoding RNAs through assigning ambiguous reads to unique genome region with well-predicted RNA structure <br>● Detection of candidate exogenous miRNAs transported from dietary species<br>● Using FASTQC, Cutadapt, Bowtie and EdgeR</td>
+<td align="center">2017</td>
+<td align="center">Hanyuan Zhang et all.</td>
+<td align="center">Briefings in Bioinformatics<br><br>Open Access<br><br><a href="https://www.ncbi.nlm.nih.gov/pubmed/28073746" rel="nofollow">[URL]</a><br><br>10.1093/bib/ bbw140</td>
+</tr>
+<tr>
+<td align="center">miRMOD</td>
+<td align="center">Windows</td>
+<td>● Identifies and analyzes miRNA 3’ and 5’ modifications (non-templated additions as well as trimming)<br>● Using Bowtie with reference genome/pre-miRNA<br>● Provides useful statistics about various types of miRNA modifications along with its frequencies.<br>● Target alteration analysis</td>
+<td align="center">2015</td>
+<td align="center">Abhinav Kaushik et all.</td>
+<td align="center">PeerJ<br><br>Open Access<br><br><a href="https://www.ncbi.nlm.nih.gov/pubmed/26623179" rel="nofollow">[URL]</a><br><br>10.7717/ peerj.1332</td>
+</tr>
+<tr>
+<td align="center">mirTools 2.0</td>
+<td align="center">Web</td>
+<td>● Detection of various types of ncRNAs (miRNA, tRNA, snRNA, snoRNA, rRNA and piRNA)<br>● Identify miRNA-targeted genes<br>● Performs functional annotation or miRNA targets (GO, KEGG, PPI)<br>● Detect differentially expressed ncRNAs with RPM and the Bayesian method<br>● Detect novel miRNAs using miRDeep</td>
+<td align="center">2013</td>
+<td align="center">Jinyu Wu et all.</td>
+<td align="center">RNA Biology<br><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849156/" rel="nofollow">[URL]</a><br><br>10.4161/ rna.25193</td>
+</tr>
+<tr>
+<td align="center">Chimira</td>
+<td align="center">Web</td>
+<td>● Sequences are automatically cleaned, trimmed, size selected and mapped directly to miRNA hairpin sequences<br>● Identifies epi-transcriptomic modifications in the input sequences. <br>● Alignment with BLAST to miRbase and differential Expression of miRNAs using Deseq2<br>● Modification profiles of 3’ and 5’ and internal modifications, uridylation, adenylation and internal modifications or variations of the miRNAs.</td>
+<td align="center">2015</td>
+<td align="center">Dimitrios M. Vitsios et all.</td>
+<td align="center">Bioinformatics<br><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595902/" rel="nofollow">[URL]</a><br><br>10.1093/ bioinformatics/ btv380</td>
+</tr>
+<tr>
+<td align="center">miRTOP</td>
+<td align="center">Standalone<br>Linux</td>
+<td>● Generation of a new file format mirGFF3.<br>● It is compatible with the commonly used tools output files (sRNAbench, Prost!, isomiR-SEA, OptimiR e.g.).<br>● Converts mirGFF3 file into several different types such as count matrix, FASTA and VCF formats.<br>● Open source and community-based project.</td>
+<td align="center">2019</td>
+<td align="center">Thomas Desvignes et all.</td>
+<td align="center">Bioinformatics<br><br>Open Access<br><br><a href="https://academic.oup.com/bioinformatics/article/36/3/698/5556118" rel="nofollow">[URL]</a><br><br>10.1093/ bioinformatics/ btz675</td>
+</tr>
+<tr>
+<td align="center">Prost!</td>
+<td align="center">Standalone<br>Linux</td>
+<td>● Aligns reads to a user-defined genomic dataset.<br>● Groups reads based on their potential genomic origins, seed sequence and annotation.<br>● Reports frequencies of individual sequence variations with respect to reference genome and the most expressed sequence. <br>● Uses Cutadapt and FASTX-toolkit for preprocessing, BBMap suite for alignment, MirBase for annotation and Deseq2 for differential expression.</td>
+<td align="center">2019</td>
+<td align="center">Thomas Desvignes et all.</td>
+<td align="center">Nature<br><br>Open Access<br><br><a href="https://www.nature.com/articles/s41598-019-40361-8" rel="nofollow">[URL]</a><br><br>10.1038/ s41598-019- 40361-8</td>
+</tr>
+<tr>
+<td align="center">OptimiR</td>
+<td align="center">Standalone<br>Linux</td>
+<td>● Detect genotyping errors<br>● Suggested the existence of novel miRNAs and highlighted the allelic imbalance expression of polymiRs in heterozygous carriers.<br>● Uses Cutadapt for preprocessing, Bowtie2 for alignment and miRBase for annotation.<br>● Uses a scoring algorithm to identify the most plausible alignments.<br>● Produces a comparison analysis of genotype data provided by the user and the genotype data that could be inferred from the sequenced reads aligned to polymiRs</td>
+<td align="center">2019</td>
+<td align="center">Florian Thibord et all.</td>
+<td align="center">Bioinformatics<br><br>Open Access<br><br><a href="https://rnajournal.cshlp.org/content/early/2019/02/28/rna.069708.118" rel="nofollow">[URL]</a><br><br>10.1261/ rna.069708.118</td>
+</tr>
+<tr>
+<td align="center">isomiRs: Analyze isomiRs and miRNAs from small RNA-seq</td>
+<td align="center">R library</td>
+<td>● Uses as input file the count matrix<br>● Includes various functions for characterization of miRNAs and isomiRs, clustering, differential expression and visualizations.<br>● Designed to analyze the output of SeqBuster tool or any other tool after converting to the desire format<br>● user can control the analysis step by step.</td>
+<td align="center">2020</td>
+<td align="center">Pantano L, Escaramis G</td>
+<td align="center">Bioconductor<br><br><a href="http://bioconductor.org/packages/release/bioc/html/isomiRs.html" rel="nofollow">[URL]</a><br><br>10.18129/ B9.bioc.isomiRs</td>
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