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planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/bigscape/ commit 8a0f3092ca824856263328efe66941409f527ca4
author | iuc |
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date | Sun, 11 Aug 2024 21:09:00 +0000 |
parents | a9e5d237d7d4 |
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LOCUS NW_022985561 47632 bp DNA linear CON 21-APR-2020 DEFINITION Pseudovirgaria hyperparasitica strain CBS 121739 unplaced genomic scaffold EJ05scaffold_13, whole genome shotgun sequence. ACCESSION NW_022985561 VERSION NW_022985561.1 KEYWORDS . SOURCE Pseudovirgaria hyperparasitica ORGANISM Pseudovirgaria hyperparasitica Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes; Dothideomycetes incertae sedis; Acrospermales; Acrospermaceae; Pseudovirgaria. COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to ML996577. URL -- http://genome.jgi.doe.gov/Psehy1 JGI Project ID: 1032442 The DNA was provided by Pedro Crous (p.crous@westerdijkinstitute.nl) The strain is available from CBS collection Contacts: Pedro Crous (p.crous@westerdijkinstitute.nl) Assembly and annotation done by JGI. The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2023-11-19 23:27:26 NOTE: This is a single region extracted from a larger record! Orig. start :: 502828 Orig. end :: 550460 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..47632 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="False" /core_location="[20000:27632]" /cutoff="0" /detection_rule="cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS-like" /protocluster_number="1" /tool="antismash" proto_core 20001..27632 /aStool="rule-based-clusters" /tool="antismash" /cutoff="0" /detection_rule="cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS-like" /protocluster_number="1" protocluster 1..47632 /aStool="rule-based-clusters" /category="PKS" /contig_edge="False" /core_location="[20000:27632]" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="2" /tool="antismash" proto_core 20001..27632 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="2" cand_cluster 1..47632 /SMILES="NCC(=O)CC(O)C(=O)O" /candidate_cluster_number="1" /contig_edge="False" /detection_rules="cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))" /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /kind="chemical_hybrid" /product="NRPS-like" /product="T1PKS" /protoclusters="1" /protoclusters="2" /tool="antismash" region 1..47632 /candidate_cluster_numbers="1" /contig_edge="False" /product="NRPS-like" /product="T1PKS" /region_number="2" /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))" /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /tool="antismash" gene 767..>2002 /db_xref="GeneID:54490143" /locus_tag="EJ05DRAFT_532751" mRNA join(767..1166,1222..1358,1412..1889,1980..>2002) /db_xref="GeneID:54490143" /locus_tag="EJ05DRAFT_532751" /product="uncharacterized protein" /transcript_id="XM_033749089.1" CDS join(899..1166,1222..1358,1412..1889,1980..2002) /codon_start=1 /db_xref="GeneID:54490143" /db_xref="InterPro:IPR002529" /db_xref="JGIDB:Psehy1_532751" /locus_tag="EJ05DRAFT_532751" /product="uncharacterized protein" /protein_id="XP_033597916.1" /transl_table=1 /translation="MPAWTRLIRFVDEDDIERYGEPIVNSGDEVIPLYEAGRLEATVLS GTTFSESGLTPEKGVTKFVKELLSPLTPKDVPIVRCVGLNYMKHIKEGGRTAPPYPSIF IKGSPSIAQWNETIPIPPVAHTDSTDYEGELCFVVGRTAKDIPREDALSYIAGYLVGND ISNRAWQRDPAYAGSVPQWGFSKGFDKYAPLGPVIVSPSILKSADDLRLQTFVNGELRQ DTGTDDMLFDVTTILSFISQGTTIEAGTVVMTGTPSGVGFGFKPEPKYLTHEDEVEVRI TGLGSVRNKIRFEVYGFFFV" PFAM_domain join(1136..1166,1222..1358,1412..1879) /aSDomain="FAA_hydrolase" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01557.21" /db_xref="GO:0003824" /description="Fumarylacetoacetate (FAA) hydrolase family" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532751_0013" /evalue="1.70E-55" /gene_ontologies="GO:0003824: catalytic activity" /label="EJ05DRAFT_532751" /locus_tag="EJ05DRAFT_532751" /protein_end="291" /protein_start="79" /score="188.4" /tool="antismash" /translation="RCVGLNYMKHIKEGGRTAPPYPSIFIKGSPSIAQWNETIPIPPVA HTDSTDYEGELCFVVGRTAKDIPREDALSYIAGYLVGNDISNRAWQRDPAYAGSVPQWG FSKGFDKYAPLGPVIVSPSILKSADDLRLQTFVNGELRQDTGTDDMLFDVTTILSFISQ GTTIEAGTVVMTGTPSGVGFGFKPEPKYLTHEDEVEVRITGLGSVRNKI" CDS complement(join(2145..2926,2979..3504)) /codon_start=1 /db_xref="GeneID:54490636" /db_xref="InterPro:IPR008654" /db_xref="JGIDB:Psehy1_540195" /locus_tag="EJ05DRAFT_540195" /product="uncharacterized protein" /protein_id="XP_033597917.1" /transl_table=1 /translation="MDDIQTPPDDATVQTPVMPEGNADPGDPLGPDVEEENNPDAPEVF PQEDVELTGENEVDKDGEDSDNESVLSDVDEAQFEDFNPADIAIEDQPVALDDDLLGQI KVSKRKRGEDGEGGVQKKKKEGRREKPKNRKKRDEDHFSGGEELEGKRSRKKDRVRAAT PVEDDTNLTPEERRRRALDRAMDEAQRKPKVRRKKDGIDLEAMADAEIEDMRKRMTDAA ANDAEDRKHGRPAMRKLKLLPEVVSLLNKNTLQNSLVDPDLNLLQAVCFFLEPLHDGSL PAYNIQRELFDALGKLPITKDALTASGIGKVVYFYTKTKRAEPGIKRHAEKLVADWTRP ILRRNDDYRKKDVAQADYDPTRLPIRNSQSNSQAAIAAAARARALAAPARSNRARVETE HMSYTIAPRSNVVGSDVKQSRNPFTLKLNRGKGVKR" gene complement(<2145..3518) /db_xref="GeneID:54490636" /locus_tag="EJ05DRAFT_540195" mRNA complement(join(<2145..2926,2979..3518)) /db_xref="GeneID:54490636" /locus_tag="EJ05DRAFT_540195" /product="uncharacterized protein" /transcript_id="XM_033749582.1" PFAM_domain complement(2430..2579) /aSDomain="Med26" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF08711.14" /description="TFIIS helical bundle-like domain" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_540195_0014" /evalue="2.40E-11" /label="EJ05DRAFT_540195" /locus_tag="EJ05DRAFT_540195" /protein_end="341" /protein_start="291" /score="43.6" /tool="antismash" /translation="DALGKLPITKDALTASGIGKVVYFYTKTKRAEPGIKRHAEKLVAD WTRPI" PFAM_domain join(3778..3790,3839..3937,3991..4019) /aSDomain="Tom5" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF10642.12" /description="Mitochondrial import receptor subunit or translocase" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_502926_0015" /evalue="9.90E-20" /label="EJ05DRAFT_502926" /locus_tag="EJ05DRAFT_502926" /protein_end="47" /protein_start="0" /score="70.4" /tool="antismash" /translation="MFGGPPPAPSQAELKAQEEAASNELKFALSTCFALYLSPFVIDYV RK" gene <3778..>4028 /db_xref="GeneID:54488388" /locus_tag="EJ05DRAFT_502926" mRNA join(<3778..3790,3839..3937,3991..>4028) /db_xref="GeneID:54488388" /locus_tag="EJ05DRAFT_502926" /product="uncharacterized protein" /transcript_id="XM_033747334.1" CDS join(3778..3790,3839..3937,3991..4028) /codon_start=1 /db_xref="GeneID:54488388" /db_xref="JGIDB:Psehy1_502926" /locus_tag="EJ05DRAFT_502926" /product="uncharacterized protein" /protein_id="XP_033597918.1" /transl_table=1 /translation="MFGGPPPAPSQAELKAQEEAASNELKFALSTCFALYLSPFVIDYV RKLV" gene complement(4205..5630) /db_xref="GeneID:54485520" /locus_tag="EJ05DRAFT_478473" mRNA complement(join(4205..4341,4390..5042,5094..5630)) /db_xref="GeneID:54485520" /locus_tag="EJ05DRAFT_478473" /product="uncharacterized protein" /transcript_id="XM_033744466.1" CDS complement(join(4228..4341,4390..5042,5094..5472)) /codon_start=1 /db_xref="GeneID:54485520" /db_xref="JGIDB:Psehy1_478473" /locus_tag="EJ05DRAFT_478473" /note="expressed protein" /product="uncharacterized protein" /protein_id="XP_033597919.1" /transl_table=1 /translation="MFGASAAKPNPFGGFGASTQQQPAQQSTGLFGSLGASQQQNQQQP RPSLFGGLGQSQQQQQQQQQQQQQQQQQQQQQQQQQQQQPTPQQQASLYASQFGGSQLG NSTSQLPKLGQSAIWEPPQQGPREKSVPEQLSTILEKWHPESPNCLFQYYFYNNVDPRV VPFYTPGPGEDERKWEEALSKKPSEGSIPVLAKGFKEVGTRLSLQSSTVQALQVRLHEI NNSLNMMMQKHELEWTVKIAEAKRRHIALSQRALALATKVQVLRNRGYAMESSEEELRK KLIELEKKAFDPVASGRQEEIWARLSTLRQQAQWLQSESEKLGNQVSDGDNGVDPDKMK QVEKILKDYKSQLDHLEKEVGSLKLEFEDWQGKSQNSLNGR" PFAM_domain complement(join(4273..4341,4390..4398)) /aSDomain="Nup54_57_C" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF18570.4" /description="NUP57/Nup54 C-terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_478473_0017" /evalue="5.10E-06" /label="EJ05DRAFT_478473" /locus_tag="EJ05DRAFT_478473" /protein_end="367" /protein_start="341" /score="26.1" /tool="antismash" /translation="VEKILKDYKSQLDHLEKEVGSLKLEF" PFAM_domain complement(4504..4914) /aSDomain="Nup54" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF13874.9" /description="Nucleoporin complex subunit 54" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_478473_0016" /evalue="2.10E-40" /label="EJ05DRAFT_478473" /locus_tag="EJ05DRAFT_478473" /protein_end="306" /protein_start="169" /score="138.2" /tool="antismash" /translation="GPGEDERKWEEALSKKPSEGSIPVLAKGFKEVGTRLSLQSSTVQA LQVRLHEINNSLNMMMQKHELEWTVKIAEAKRRHIALSQRALALATKVQVLRNRGYAME SSEEELRKKLIELEKKAFDPVASGRQEEIWARL" gene <5805..>6432 /db_xref="GeneID:54488389" /locus_tag="EJ05DRAFT_502928" mRNA join(<5805..5824,5877..6104,6168..6300,6355..>6432) /db_xref="GeneID:54488389" /locus_tag="EJ05DRAFT_502928" /product="NADH-ubiquinone oxidoreductase-like protein 20.8 kDa subunit" /transcript_id="XM_033747335.1" CDS join(5805..5824,5877..6104,6168..6300,6355..6432) /codon_start=1 /db_xref="GeneID:54488389" /db_xref="InterPro:IPR010625" /db_xref="JGIDB:Psehy1_502928" /locus_tag="EJ05DRAFT_502928" /product="NADH-ubiquinone oxidoreductase-like protein 20.8 kDa subunit" /protein_id="XP_033597920.1" /transl_table=1 /translation="MSTRVPRFNKTSLYDTTPLPDDIPKVKEIGASSAPLMSAAFFIGA RCKAYNDDYMQCKTESNGRGELECMKEGRKVTRCAASVLEDINKNCLEEFKKHWDCLEN NNQQLWHCRAQERPFNKCVFDKLNLEKTIPGTPENVTPVHLRKYQKFS" PFAM_domain 6190..6291 /aSDomain="CHCH" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF06747.16" /description="CHCH domain" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_502928_0018" /evalue="9.80E-08" /label="EJ05DRAFT_502928" /locus_tag="EJ05DRAFT_502928" /protein_end="124" /protein_start="90" /score="32.1" /tool="antismash" /translation="CLEEFKKHWDCLENNNQQLWHCRAQERPFNKCVF" gene complement(<9295..>10154) /db_xref="GeneID:54487209" /locus_tag="EJ05DRAFT_493992" mRNA complement(join(<9295..9340,9406..>10154)) /db_xref="GeneID:54487209" /locus_tag="EJ05DRAFT_493992" /product="HET-domain-containing protein" /transcript_id="XM_033746155.1" CDS complement(join(9295..9340,9406..10154)) /codon_start=1 /db_xref="GeneID:54487209" /db_xref="InterPro:IPR010730" /db_xref="JGIDB:Psehy1_493992" /locus_tag="EJ05DRAFT_493992" /product="HET-domain-containing protein" /protein_id="XP_033597921.1" /transl_table=1 /translation="MRLLRVKDWLFEDGTPDRKYAILSHTWIQEASEEVYYPDIRDIAL RSDEENALLKGRRGWSKVSNTVAQAVRDGLEYVWIDTCCIDQKNPTELTTSINSMFEWY AKATVCYVYLEDVFKTATPSQIDFSKARWSTRGWTLQELIAPKSVIFFDATWDLLSTRA DSACDLSRVTSIDEEVLRDGPNNLSAYSVAKRMSWAAGRCTSRPEDRAYSLFGIFGITM PTHYGEGGKNAFVRLQEEIIKYSDDQSLKWYSFTPGSIARPL" PFAM_domain complement(9804..10097) /aSDomain="HET" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF06985.14" /description="Heterokaryon incompatibility protein (HET)" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_493992_0019" /evalue="6.30E-10" /label="EJ05DRAFT_493992" /locus_tag="EJ05DRAFT_493992" /protein_end="117" /protein_start="19" /score="39.7" /tool="antismash" /translation="YAILSHTWIQEASEEVYYPDIRDIALRSDEENALLKGRRGWSKVS NTVAQAVRDGLEYVWIDTCCIDQKNPTELTTSINSMFEWYAKATVCYVYLEDV" gene <10547..>11332 /db_xref="GeneID:54488390" /locus_tag="EJ05DRAFT_502930" mRNA join(<10547..10572,10624..>11332) /db_xref="GeneID:54488390" /locus_tag="EJ05DRAFT_502930" /product="uncharacterized protein" /transcript_id="XM_033747336.1" CDS join(10547..10572,10624..11332) /codon_start=1 /db_xref="GeneID:54488390" /db_xref="JGIDB:Psehy1_502930" /locus_tag="EJ05DRAFT_502930" /note="expressed protein" /product="uncharacterized protein" /protein_id="XP_033597922.1" /transl_table=1 /translation="MTDQADLQVVGRDALRSAESSRSPSPDHDNCATNTFRELLNKRFG AIEDIEILDTPPAFSAVDVGDDIEDTELRLFASQSAPTKIDLRSPSPPGGEPGFVQPER PLSYYLAESPSAQDQIRLALAAVSGEEVLDRSHARWAGCALPWRVHTVIPETILGTKIH MSELQRRRRPSKKARIALRAKQKAKLMKEEEAKRAAQEKEQYLREKKSAENRKKQLKKR AKERAKKAETGIAARDISMSAD" PFAM_domain 10811..11050 /aSDomain="DUF2011" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF09428.13" /description="Fungal protein of unknown function (DUF2011)" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_502930_0020" /evalue="8.40E-22" /label="EJ05DRAFT_502930" /locus_tag="EJ05DRAFT_502930" /protein_end="151" /protein_start="71" /score="77.4" /tool="antismash" /translation="ELRLFASQSAPTKIDLRSPSPPGGEPGFVQPERPLSYYLAESPSA QDQIRLALAAVSGEEVLDRSHARWAGCALPWRVHT" gene 11752..13547 /db_xref="GeneID:54480001" /locus_tag="EJ05DRAFT_102516" mRNA 11752..13547 /db_xref="GeneID:54480001" /locus_tag="EJ05DRAFT_102516" /product="uncharacterized protein" /transcript_id="XM_033738947.1" CDS 12172..13131 /codon_start=1 /db_xref="GeneID:54480001" /db_xref="JGIDB:Psehy1_102516" /locus_tag="EJ05DRAFT_102516" /note="expressed protein" /product="uncharacterized protein" /protein_id="XP_033597923.1" /transl_table=1 /translation="MFPARISQLALFIASATALFKQWCMAYRYPRTVSYADLCEDTCVV VSQILHHFFTAAAGFSIEAKGNLEHPVRVRLTKKHKKTTIPADQIYEYHIKHYNPSLVA PSWAGPSDISSFWALVLAIASPPQVRALWCPDTTDNELHAYTKRVMTEEGVRAGPVLII NNDKMEFFWFSAGASGAYCWLDRTSFGVPVDPSVQLAPGRLGHVELLMRGLLKQETWLG VGRGFSGVRVGEKGRVGTRSLDVRCPHPERTWALEVGGEERRGEAVLESPPMSPLTEVG EELVEERRGEEGGRKRKREVEVDGGPDGERAAKRVRWE" gene complement(13548..15265) /db_xref="GeneID:54480002" /locus_tag="EJ05DRAFT_102556" mRNA complement(join(13548..14499,14548..15265)) /db_xref="GeneID:54480002" /locus_tag="EJ05DRAFT_102556" /product="uncharacterized protein" /transcript_id="XM_033738948.1" CDS complement(join(13964..14499,14548..14992)) /codon_start=1 /db_xref="GeneID:54480002" /db_xref="JGIDB:Psehy1_102556" /locus_tag="EJ05DRAFT_102556" /note="expressed protein" /product="uncharacterized protein" /protein_id="XP_033597924.1" /transl_table=1 /translation="MSDRSSSTPPEWLMPSEERHSEWTSASLDVLEETIANLIERLTNK TQPDKIQKINRIQEEEDEFGQYHMPLSNPDDIPLQREINAQWDTVRTCLLPNGQDEGFL HERLQTILTKMRARGSDLLGDGTEIEQLIFIWYAVVCLLQDINAENYLHGRDGDDDINY DKASPFYKYPDVSLFSKIDGAWAALDRGIMNLLSGINAERSPAELPGWNRMATHFHRGS VLADLVYWNPDEEFDRDTHHMNIMAEPMNNTLGPRSRLCYELIVAYEWRGYYPDRKMNT IRLLEAKLDSGKDANSDKVSSLSSTPESLDLSEGSPPSVAEEEEE" gene complement(<16397..>17734) /db_xref="GeneID:54488391" /locus_tag="EJ05DRAFT_502933" mRNA complement(<16397..>17734) /db_xref="GeneID:54488391" /locus_tag="EJ05DRAFT_502933" /product="uncharacterized protein" /transcript_id="XM_033747337.1" CDS complement(16397..17734) /codon_start=1 /db_xref="GeneID:54488391" /db_xref="InterPro:IPR001138" /db_xref="JGIDB:Psehy1_502933" /locus_tag="EJ05DRAFT_502933" /note="expressed protein" /product="uncharacterized protein" /protein_id="XP_033597925.1" /transl_table=1 /translation="MSIGDNTRLRASCERCRGQKLRCLPTSDSTPGAPCQRCIKAKTAE SCVFIPRSRAPRPARSRASSSDISRCKDSTTETALPGTSVFALTPNPSPDCFEAYQSFT STPTHGTAQLFNSDEAYAAPPGSTDLVSTYWEANLGGLLAQDSWNESMLMDSDPSSLEC SQPAESPIEDPARAETSDSVGSPPKSWPLDGNSIDLESTTDNEQQDGSVDPLLHLTNLL AEMYRYEQQLARLPVKDALEYPVGDALYFSQLFRSILLPTGILSQESAISALSTPTILL VLSCFVTLYRIYTFIFRHFVTSLSQDPSLNQPLNRLAETRSYRGLRLAQLHKVCFCSHG ELIKSAALLLLESLGETEDLLEIPVDARATTVRGGSSTASPNSTRGTQNSGESLTTEQG SPFMAKSEVFYHAVGLHAKDLQRQVEQLMDMFKRMSVRAREHCRAL" gene complement(19613..>27632) /db_xref="GeneID:54490144" /locus_tag="EJ05DRAFT_532754" mRNA complement(join(19613..25793,25827..>27632)) /db_xref="GeneID:54490144" /locus_tag="EJ05DRAFT_532754" /product="nonribosomal peptide synthetase 7" /transcript_id="XM_033749090.1" CDS complement(join(20001..25793,25827..27632)) /NRPS_PKS="Domain: AMP-binding (35-427). E-value: 1.9e-109. Score: 357.8. Matches aSDomain: nrpspksdomains_EJ05DRAFT_532754_AMP-binding.1" /NRPS_PKS="Domain: PCP (540-602). E-value: 6.2e-14. Score: 43.9. Matches aSDomain: nrpspksdomains_EJ05DRAFT_532754_PCP.1" /NRPS_PKS="Domain: PKS_KS(Modular-KS) (617-1039). E-value: 2e-167. Score: 549.2. Matches aSDomain: nrpspksdomains_EJ05DRAFT_532754_PKS_KS.1" /NRPS_PKS="Domain: PKS_AT (1163-1460). E-value: 3.6e-96. Score: 313.9. Matches aSDomain: nrpspksdomains_EJ05DRAFT_532754_PKS_AT.1" /NRPS_PKS="Domain: PKS_KR (1755-1934). E-value: 4.9e-58. Score: 187.9. Matches aSDomain: nrpspksdomains_EJ05DRAFT_532754_PKS_KR.1" /NRPS_PKS="Domain: ACP (2043-2114). E-value: 2.8e-22. Score: 70.7. Matches aSDomain: nrpspksdomains_EJ05DRAFT_532754_ACP.1" /NRPS_PKS="Domain: NAD_binding_4 (2175-2405). E-value: 1.7e-51. Score: 166.6. Matches aSDomain: nrpspksdomains_EJ05DRAFT_532754_NAD_binding_4.1" /codon_start=1 /db_xref="GeneID:54490144" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR006163" /db_xref="InterPro:IPR013120" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR014043" /db_xref="JGIDB:Psehy1_532754" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: mod_KS" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_AT" /gene_functions="biosynthetic (rule-based-clusters) NRPS-like: PP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS-like: AMP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS-like: NAD_binding_4" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002:AMP-dependent synthetase and ligase (Score: 347.9; E-value: 1.3e-105)" /gene_kind="biosynthetic" /locus_tag="EJ05DRAFT_532754" /note="polyketide synthase" /product="nonribosomal peptide synthetase 7" /protein_id="XP_033597926.1" /sec_met_domain="AMP-binding (E-value: 1e-116, bitscore: 384.9, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="mod_KS (E-value: 3.2e-179, bitscore: 591.2, seeds: 217, tool: rule-based-clusters)" /sec_met_domain="PKS_AT (E-value: 3.3e-95, bitscore: 313.9, seeds: 1682, tool: rule-based-clusters)" /sec_met_domain="adh_short (E-value: 7e-54, bitscore: 177.4, seeds: 230, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 2.1e-12, bitscore: 42.4, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="NAD_binding_4 (E-value: 1.6e-50, bitscore: 166.6, seeds: 102, tool: rule-based-clusters)" /transl_table=1 /translation="MSDTCSSRAQEGVGDEFNATDDATTLGLCLHHLIDQVIKTNSENV AAICGDQKLSYAELGALVDRYASILEQHSVKRGDLVGIVLDRSLMLVVVLLAVLKAGAA YVPIDPTFPQDRIHHMLEDADPKLVVVEASTESSMSFWRGPALNIDTVEKKLPHSTTAS DSHVDPDDLAYVIYTSGSTGKPKGVEISHEALCNLLLGIKSTSGPGCRASDRLLAVTTI SFDIAMLEIFLPLICGATVVVAQKAETRDPRALMSMIKRHSITIMQATPATWQMILESG WHSDVHLSTIICGGEALPQKLANRLLSCAESVWNVYGPTEATVWASMWRVCPDQPVVIG RPINNYRLYVLDNNDLSRVPIGTEGELFIGGASLARGYHKKPEITQERFIHNPFHPGLM YRTGDLARFDSLDSLRVLGRADGQVKIRGFRIEVGDIEAAITDHDDIAEAVVNAQQGRL VAYCIRKQKTQTKNGCEDSRSIETFLRPFLKSRLPEYMMPAFYLELKEFPMTPNKKIDR KALPVHTEVVKPQAMSQQPQTGLESSIRLIWSEVLGHDRITTEANFFEIGGDSIRVIKV QKALEQLLDRILSPAILFEHFTIKALPDRGLSTNHITADESIAIVSMACQLPGGVTSPQ EFWDLLERGADVITSVPKDRWDAEELYSAGLSYCRRGGFLDSVDEFDAPFFGISPREAR SLDPTQRIGLETCWEGLERAGYTAGQLRGSNTGVYMGVCTISAHNSSVPSLGELDGYAI TGTAGSTLSGRVSYAFGLEGPNMTIDTACSSSLVTTHLACNALRQGECDLAISGGISLL LSPAMHVEFSRLNGMSIDGRCRAFANDNSGTGWSEGCTVVVLKRLSDAMRDKDHIHAVI RGTAVNHGGRSAPGLTVPSGKAQQRLIQTALQASRLSPGDIDLVEAHGTGTRLGDPIEG VALAGVYGGSRSVDDEPLWVGSCKSSFGHTQAAAGLAGVIKVVMAMKNNKIPQTLHATK PTQAVDWEGSRMALVQEAQPWHPRLKRARRAGVSAFGISGTNAHVVVEEPPRQIPDHQL DQDDGDSDVEATELPHYQSLESRRSVAMPFLLSGHTEVSLAQQAEKLKQHISAHGQGPN FRLRDIAFSLATTRTLFGRRDIVWAKNRTTLISGLDSIAQTSSASIPATSTSRLAMLFT GQGSQACGMGKGLYEAYPIFRVALDEIVARFSGLDVPLLEVMHAPSGSEAASLLQRTDY AQPALFSLGVALWSLWKSWGVVPDVLCGHSVGELVAAHVAGVLSLTDACILVEARGRLM QAVPMQGAMVSLQASWEEVEKAIDALELNGQIDIAGRNTPMQTVASGDISAVERIASYF AGYERKTKLLDVSKAFHSHHMDTILTAFRSVAENVEFKRPQLPIVSTLTGRLCEPGEME TPDYWVQQIRQAVRFTDAVQTLFLQDTTSFVELGPRPILAGMGAACLENEQTITWLPSI IHGKDEATTIQRSLTELHKKDISIDWTGYFGSIKGCQRVELPTYAFHKERYPPLRKNTL SPPDGHQGLSMNAIKAQDMNDPPDASIEPRATELAITWKESSSKGTITADPSKLTGTWG MIRSNYSGPLSMKIMDGLLQNGLSVRWVDLQDINTWTDLSGLLCVWEPQVENDVDHVEQ LTTEAFAQLQAIIRAQLAQPLLWVTLNAVDTGSGEIELPGLHSSTLWGLMRTARNEHTE LSLRLVDLDINLAADTSLVKALAMINEPECAVRHSGILLPRLENVNITSRGAQLLRTDG AVIITGGLGSLGRRVAMWLAISHNIRDIVLLSRRGTDTPGTDSFVKELADAGAQATVLS CDIASRESVDNAISLFTALRPLRGVVHTAGLLDDGALQDLTPERINRVLGPKVHGAWNL HQSTQGLDLDMFLIFSSISGIIGNPGQSSYAAANTFLDALAYFRRSQRLPGTSVAYGPW AGGGMAEKLSKLGLARWQRMGFNMIQSDESLQLTENAIRSGRPLAAVAVLDPGRLHRFL SNDLDERSTLLSLLQGQKGRKVPPKDLKNKKEDLRSMLKQSAVTEQGEIVLTTVKATVA RILGIAHSGDVDSDRALQDIGIDSLTAVQVRNHLEKSTGLKLNARIAFQYPNLRALSKF LLTSLQEDMMDSDDSSTGDISTPPTSVKSESIAPSIDIAAIKKGYLDPTLKFRSTEPTK PPNAVFVTGATGFVGAFIAAELLSMGISVHCLVRAGSDQAARQRLLDSLAAHDLWKPSF EPLLHAIVGDMSQPLFGLPDEQFQYLTETIDSICHSGGLVDWVRPLDDYLGPNIVSTHE ILRLASQGREKTVHFISTMSTLPVYMGLELVEGDGEYGYATSKYTAERMVAAARWRGAN ASVYRLPFVTASTESGCFRLDRGDFMHSFISGCLEMGFFPSLDGADLAAVLPVDYLATT IVTKMTQDFESVGKDYDFANANPLSFNAFWKLLSLASAGQEIVPFVEWRERAFAHVASH RESPLARIMALIDGVKDEKNAVAFVTGPMVGPEVLGGKIYPVPEIDERVARNYVTRITI NSRGFKTGV" aSDomain complement(20145..21080) /aSDomain="TIGR01746" /aSTool="tigrfam" /description="Thioester-redct: thioester reductase domain" /detection="hmmscan" /domain_id="TIGRFam_EJ05DRAFT_532754_0002" /evalue="3.10E-67" /identifier="TIGR01746" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="2485" /protein_start="2173" /score="225.3" /tool="antismash" /translation="VFVTGATGFVGAFIAAELLSMGISVHCLVRAGSDQAARQRLLDSL AAHDLWKPSFEPLLHAIVGDMSQPLFGLPDEQFQYLTETIDSICHSGGLVDWVRPLDDY LGPNIVSTHEILRLASQGREKTVHFISTMSTLPVYMGLELVEGDGEYGYATSKYTAERM VAAARWRGANASVYRLPFVTASTESGCFRLDRGDFMHSFISGCLEMGFFPSLDGADLAA VLPVDYLATTIVTKMTQDFESVGKDYDFANANPLSFNAFWKLLSLASAGQEIVPFVEWR ERAFAHVASHRESPLARIMALIDGVKDEKNA" PFAM_domain complement(20382..21074) /aSDomain="NAD_binding_4" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF07993.15" /description="Male sterility protein" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532754_0029" /evalue="4.10E-48" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="2406" /protein_start="2175" /score="163.9" /tool="antismash" /translation="VTGATGFVGAFIAAELLSMGISVHCLVRAGSDQAARQRLLDSLAA HDLWKPSFEPLLHAIVGDMSQPLFGLPDEQFQYLTETIDSICHSGGLVDWVRPLDDYLG PNIVSTHEILRLASQGREKTVHFISTMSTLPVYMGLELVEGDGEYGYATSKYTAERMVA AARWRGANASVYRLPFVTASTESGCFRLDRGDFMHSFISGCLEMGFFPSLDGADLAAVL PVDYLATTI" aSDomain complement(20385..21074) /aSDomain="NAD_binding_4" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EJ05DRAFT_532754_NAD_binding_4.1 " /evalue="1.70E-51" /label="EJ05DRAFT_532754_NAD_binding_4.1" /locus_tag="EJ05DRAFT_532754" /protein_end="2405" /protein_start="2175" /score="166.6" /tool="antismash" /translation="VTGATGFVGAFIAAELLSMGISVHCLVRAGSDQAARQRLLDSLAA HDLWKPSFEPLLHAIVGDMSQPLFGLPDEQFQYLTETIDSICHSGGLVDWVRPLDDYLG PNIVSTHEILRLASQGREKTVHFISTMSTLPVYMGLELVEGDGEYGYATSKYTAERMVA AARWRGANASVYRLPFVTASTESGCFRLDRGDFMHSFISGCLEMGFFPSLDGADLAAVL PVDYLATT" aSModule complement(20385..25748) /complete /domains="nrpspksdomains_EJ05DRAFT_532754_PKS_KS.1" /domains="nrpspksdomains_EJ05DRAFT_532754_PKS_AT.1" /domains="nrpspksdomains_EJ05DRAFT_532754_PKS_KR.1" /domains="nrpspksdomains_EJ05DRAFT_532754_ACP.1" /domains="nrpspksdomains_EJ05DRAFT_532754_NAD_binding_4.1" /locus_tags="EJ05DRAFT_532754" /monomer_pairings="mal -> ohmal" /tool="antismash" /type="pks" CDS_motif complement(21015..21077) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0015" /evalue="5.40E-01" /label="PKSI-KR_m1" /locus_tag="EJ05DRAFT_532754" /protein_end="2195" /protein_start="2174" /score="3.0" /tool="antismash" /translation="FVTGATGFVGAFIAAELLSMG" aSDomain complement(21258..21470) /ASF="found active site serine: True" /ASF="non-beta-branching ACP" /aSDomain="ACP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EJ05DRAFT_532754_ACP.1" /evalue="2.80E-22" /label="EJ05DRAFT_532754_ACP.1" /locus_tag="EJ05DRAFT_532754" /protein_end="2114" /protein_start="2043" /score="70.7" /tool="antismash" /translation="TTVKATVARILGIAHSGDVDSDRALQDIGIDSLTAVQVRNHLEKS TGLKLNARIAFQYPNLRALSKFLLTS" PFAM_domain complement(21267..21467) /aSDomain="PP-binding" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00550.28" /description="Phosphopantetheine attachment site" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532754_0028" /evalue="5.40E-11" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="2111" /protein_start="2044" /score="42.8" /tool="antismash" /translation="TVKATVARILGIAHSGDVDSDRALQDIGIDSLTAVQVRNHLEKST GLKLNARIAFQYPNLRALSKFL" aSDomain complement(21798..22334) /ASF="KR domain putatively catalyzing D-configuration product formation" /ASF="catalytic triad S,Y,N found: True" /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EJ05DRAFT_532754_PKS_KR.1" /evalue="4.90E-58" /label="EJ05DRAFT_532754_PKS_KR.1" /locus_tag="EJ05DRAFT_532754" /protein_end="1934" /protein_start="1755" /score="187.9" /specificity="KR activity: active" /specificity="KR stereochemistry: B1" /tool="antismash" /translation="GAVIITGGLGSLGRRVAMWLAISHNIRDIVLLSRRGTDTPGTDSF VKELADAGAQATVLSCDIASRESVDNAISLFTALRPLRGVVHTAGLLDDGALQDLTPER INRVLGPKVHGAWNLHQSTQGLDLDMFLIFSSISGIIGNPGQSSYAAANTFLDALAYFR RSQRLPGTSVAYGPWA" PFAM_domain complement(21798..22334) /aSDomain="KR" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF08659.13" /description="KR domain" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532754_0027" /evalue="1.50E-59" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="1934" /protein_start="1755" /score="201.0" /tool="antismash" /translation="GAVIITGGLGSLGRRVAMWLAISHNIRDIVLLSRRGTDTPGTDSF VKELADAGAQATVLSCDIASRESVDNAISLFTALRPLRGVVHTAGLLDDGALQDLTPER INRVLGPKVHGAWNLHQSTQGLDLDMFLIFSSISGIIGNPGQSSYAAANTFLDALAYFR RSQRLPGTSVAYGPWA" CDS_motif complement(21843..21953) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0014" /evalue="5.80E-21" /label="PKSI-KR_m4" /locus_tag="EJ05DRAFT_532754" /protein_end="1919" /protein_start="1882" /score="67.1" /tool="antismash" /translation="LDMFLIFSSISGIIGNPGQSSYAAANTFLDALAYFRR" CDS_motif complement(21975..22004) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0013" /evalue="1.40E-03" /label="PKSI-KR_m3" /locus_tag="EJ05DRAFT_532754" /protein_end="1875" /protein_start="1865" /score="12.0" /tool="antismash" /translation="PKVHGAWNLH" CDS_motif complement(22230..22328) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0012" /evalue="9.40E-08" /label="PKSI-KR_m1" /locus_tag="EJ05DRAFT_532754" /protein_end="1790" /protein_start="1757" /score="24.7" /tool="antismash" /translation="VIITGGLGSLGRRVAMWLAISHNIRDIVLLSRR" PFAM_domain complement(23160..24110) /aSDomain="Acyl_transf_1" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00698.24" /description="Acyl transferase domain" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532754_0026" /evalue="4.30E-45" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="1480" /protein_start="1163" /score="154.7" /tool="antismash" /translation="LFTGQGSQACGMGKGLYEAYPIFRVALDEIVARFSGLDVPLLEVM HAPSGSEAASLLQRTDYAQPALFSLGVALWSLWKSWGVVPDVLCGHSVGELVAAHVAGV LSLTDACILVEARGRLMQAVPMQGAMVSLQASWEEVEKAIDALELNGQIDIAGRNTPMQ TVASGDISAVERIASYFAGYERKTKLLDVSKAFHSHHMDTILTAFRSVAENVEFKRPQL PIVSTLTGRLCEPGEMETPDYWVQQIRQAVRFTDAVQTLFLQDTTSFVELGPRPILAGM GAACLENEQTITWLPSIIHGKDEATTIQRSLTELHK" aSDomain complement(23220..24110) /ASF="Neither malonyl-CoA or methylmalonyl-CoA specific" /ASF="found active site serine: True, scaffold matched GHGE: True" /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EJ05DRAFT_532754_PKS_AT.1" /evalue="3.60E-96" /label="EJ05DRAFT_532754_PKS_AT.1" /locus_tag="EJ05DRAFT_532754" /protein_end="1460" /protein_start="1163" /score="313.9" /specificity="substrate consensus: mal" /specificity="PKS signature: Malonyl-CoA" /specificity="Minowa: mal" /tool="antismash" /translation="LFTGQGSQACGMGKGLYEAYPIFRVALDEIVARFSGLDVPLLEVM HAPSGSEAASLLQRTDYAQPALFSLGVALWSLWKSWGVVPDVLCGHSVGELVAAHVAGV LSLTDACILVEARGRLMQAVPMQGAMVSLQASWEEVEKAIDALELNGQIDIAGRNTPMQ TVASGDISAVERIASYFAGYERKTKLLDVSKAFHSHHMDTILTAFRSVAENVEFKRPQL PIVSTLTGRLCEPGEMETPDYWVQQIRQAVRFTDAVQTLFLQDTTSFVELGPRPILAGM GAACLENEQTITWLPS" CDS_motif complement(23349..23384) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0011" /evalue="2.90E-04" /label="PKSI-AT-M_m8" /locus_tag="EJ05DRAFT_532754" /protein_end="1417" /protein_start="1405" /score="14.3" /tool="antismash" /translation="YWVQQIRQAVRF" CDS_motif complement(23745..23867) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0010" /evalue="1.50E-21" /label="PKSI-AT-M_m3" /locus_tag="EJ05DRAFT_532754" /protein_end="1285" /protein_start="1244" /score="68.7" /tool="antismash" /translation="GVVPDVLCGHSVGELVAAHVAGVLSLTDACILVEARGRLMQ" CDS_motif complement(23871..23942) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0009" /evalue="2.40E-04" /label="PKSI-AT-mM_m2" /locus_tag="EJ05DRAFT_532754" /protein_end="1243" /protein_start="1219" /score="14.3" /tool="antismash" /translation="LQRTDYAQPALFSLGVALWSLWKS" CDS_motif complement(24060..24107) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0008" /evalue="1.90E-04" /label="PKSI-AT-M_m1" /locus_tag="EJ05DRAFT_532754" /protein_end="1180" /protein_start="1164" /score="14.2" /tool="antismash" /translation="FTGQGSQACGMGKGLY" PFAM_domain complement(24297..24632) /aSDomain="KAsynt_C_assoc" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF16197.8" /description="Ketoacyl-synthetase C-terminal extension" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532754_0025" /evalue="5.20E-12" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="1101" /protein_start="989" /score="46.4" /tool="antismash" /translation="PTQAVDWEGSRMALVQEAQPWHPRLKRARRAGVSAFGISGTNAHV VVEEPPRQIPDHQLDQDDGDSDVEATELPHYQSLESRRSVAMPFLLSGHTEVSLAQQAE KLKQHISA" aSDomain complement(24483..25748) /ASF="found active site cysteine: True, scaffold matched GSSS: True" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EJ05DRAFT_532754_PKS_KS.1" /domain_subtypes="Modular-KS" /evalue="2.00E-167" /label="EJ05DRAFT_532754_PKS_KS.1" /locus_tag="EJ05DRAFT_532754" /protein_end="1039" /protein_start="617" /score="549.2" /tool="antismash" /translation="IAIVSMACQLPGGVTSPQEFWDLLERGADVITSVPKDRWDAEELY SAGLSYCRRGGFLDSVDEFDAPFFGISPREARSLDPTQRIGLETCWEGLERAGYTAGQL RGSNTGVYMGVCTISAHNSSVPSLGELDGYAITGTAGSTLSGRVSYAFGLEGPNMTIDT ACSSSLVTTHLACNALRQGECDLAISGGISLLLSPAMHVEFSRLNGMSIDGRCRAFAND NSGTGWSEGCTVVVLKRLSDAMRDKDHIHAVIRGTAVNHGGRSAPGLTVPSGKAQQRLI QTALQASRLSPGDIDLVEAHGTGTRLGDPIEGVALAGVYGGSRSVDDEPLWVGSCKSSF GHTQAAAGLAGVIKVVMAMKNNKIPQTLHATKPTQAVDWEGSRMALVQEAQPWHPRLKR ARRAGVSAFGISGTNAHVVVEEP" PFAM_domain complement(24639..24998) /aSDomain="Ketoacyl-synt_C" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF02801.25" /description="Beta-ketoacyl synthase, C-terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532754_0024" /evalue="1.60E-39" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="987" /protein_start="867" /score="134.7" /tool="antismash" /translation="HAVIRGTAVNHGGRSAPGLTVPSGKAQQRLIQTALQASRLSPGDI DLVEAHGTGTRLGDPIEGVALAGVYGGSRSVDDEPLWVGSCKSSFGHTQAAAGLAGVIK VVMAMKNNKIPQTLHA" CDS_motif complement(24672..24728) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0007" /evalue="9.50E+00" /label="PKSI-AT-mM_m3" /locus_tag="EJ05DRAFT_532754" /protein_end="976" /protein_start="957" /score="-0.4" /tool="antismash" /translation="GHTQAAAGLAGVIKVVMAM" CDS_motif complement(24813..24857) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0006" /evalue="5.20E-04" /label="PKSI-KS_m5" /locus_tag="EJ05DRAFT_532754" /protein_end="929" /protein_start="914" /score="12.3" /tool="antismash" /translation="VEAHGTGTRLGDPIE" PFAM_domain complement(25020..25754) /aSDomain="ketoacyl-synt" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00109.29" /description="Beta-ketoacyl synthase, N-terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532754_0023" /evalue="7.20E-80" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="860" /protein_start="615" /score="268.3" /tool="antismash" /translation="ESIAIVSMACQLPGGVTSPQEFWDLLERGADVITSVPKDRWDAEE LYSAGLSYCRRGGFLDSVDEFDAPFFGISPREARSLDPTQRIGLETCWEGLERAGYTAG QLRGSNTGVYMGVCTISAHNSSVPSLGELDGYAITGTAGSTLSGRVSYAFGLEGPNMTI DTACSSSLVTTHLACNALRQGECDLAISGGISLLLSPAMHVEFSRLNGMSIDGRCRAFA NDNSGTGWSEGCTVVVLKRLSDA" CDS_motif complement(25239..25283) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0005" /evalue="2.60E-06" /label="PKSI-KS_m3" /locus_tag="EJ05DRAFT_532754" /protein_end="787" /protein_start="772" /score="19.4" /tool="antismash" /translation="GPNMTIDTACSSSLV" PFAM_domain complement(25827..26006) /aSDomain="PP-binding" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00550.28" /description="Phosphopantetheine attachment site" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532754_0022" /evalue="2.20E-09" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="602" /protein_start="542" /score="37.6" /tool="antismash" /translation="SIRLIWSEVLGHDRITTEANFFEIGGDSIRVIKVQKALEQLLDRI LSPAILFEHFTIKAL" aSDomain complement(25827..26012) /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EJ05DRAFT_532754_PCP.1" /evalue="6.20E-14" /label="EJ05DRAFT_532754_PCP.1" /locus_tag="EJ05DRAFT_532754" /protein_end="602" /protein_start="540" /score="43.9" /tool="antismash" /translation="ESSIRLIWSEVLGHDRITTEANFFEIGGDSIRVIKVQKALEQLLD RILSPAILFEHFTIKAL" aSModule complement(25827..27527) /complete /domains="nrpspksdomains_EJ05DRAFT_532754_AMP-binding.1" /domains="nrpspksdomains_EJ05DRAFT_532754_PCP.1" /locus_tags="EJ05DRAFT_532754" /monomer_pairings="Gly -> Gly" /starter_module /tool="antismash" /type="nrps" aSDomain complement(26280..27470) /aSDomain="TIGR01733" /aSTool="tigrfam" /description="AA-adenyl-dom: amino acid adenylation domain" /detection="hmmscan" /domain_id="TIGRFam_EJ05DRAFT_532754_0001" /evalue="5.30E-126" /identifier="TIGR01733" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="451" /protein_start="54" /score="418.7" /tool="antismash" /translation="SYAELGALVDRYASILEQHSVKRGDLVGIVLDRSLMLVVVLLAVL KAGAAYVPIDPTFPQDRIHHMLEDADPKLVVVEASTESSMSFWRGPALNIDTVEKKLPH STTASDSHVDPDDLAYVIYTSGSTGKPKGVEISHEALCNLLLGIKSTSGPGCRASDRLL AVTTISFDIAMLEIFLPLICGATVVVAQKAETRDPRALMSMIKRHSITIMQATPATWQM ILESGWHSDVHLSTIICGGEALPQKLANRLLSCAESVWNVYGPTEATVWASMWRVCPDQ PVVIGRPINNYRLYVLDNNDLSRVPIGTEGELFIGGASLARGYHKKPEITQERFIHNPF HPGLMYRTGDLARFDSLDSLRVLGRADGQVKIRGFRIEVGDIEAAITDHDDIAEAVV" CDS_motif complement(26322..26384) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0004" /evalue="7.50E-10" /label="NRPS-A_a8" /locus_tag="EJ05DRAFT_532754" /protein_end="437" /protein_start="416" /score="31.0" /tool="antismash" /translation="LGRADGQVKIRGFRIEVGDIE" aSDomain complement(26352..27527) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EJ05DRAFT_532754_AMP-binding.1" /evalue="1.90E-109" /label="EJ05DRAFT_532754_AMP-binding.1" /locus_tag="EJ05DRAFT_532754" /protein_end="427" /protein_start="35" /score="357.8" /specificity="substrate consensus: Gly" /tool="antismash" /translation="QVIKTNSENVAAICGDQKLSYAELGALVDRYASILEQHSVKRGDL VGIVLDRSLMLVVVLLAVLKAGAAYVPIDPTFPQDRIHHMLEDADPKLVVVEASTESSM SFWRGPALNIDTVEKKLPHSTTASDSHVDPDDLAYVIYTSGSTGKPKGVEISHEALCNL LLGIKSTSGPGCRASDRLLAVTTISFDIAMLEIFLPLICGATVVVAQKAETRDPRALMS MIKRHSITIMQATPATWQMILESGWHSDVHLSTIICGGEALPQKLANRLLSCAESVWNV YGPTEATVWASMWRVCPDQPVVIGRPINNYRLYVLDNNDLSRVPIGTEGELFIGGASLA RGYHKKPEITQERFIHNPFHPGLMYRTGDLARFDSLDSLRVLGRADGQVKIR" PFAM_domain complement(26352..27527) /aSDomain="AMP-binding" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00501.31" /description="AMP-binding enzyme" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532754_0021" /evalue="7.50E-102" /label="EJ05DRAFT_532754" /locus_tag="EJ05DRAFT_532754" /protein_end="427" /protein_start="35" /score="341.2" /tool="antismash" /translation="QVIKTNSENVAAICGDQKLSYAELGALVDRYASILEQHSVKRGDL VGIVLDRSLMLVVVLLAVLKAGAAYVPIDPTFPQDRIHHMLEDADPKLVVVEASTESSM SFWRGPALNIDTVEKKLPHSTTASDSHVDPDDLAYVIYTSGSTGKPKGVEISHEALCNL LLGIKSTSGPGCRASDRLLAVTTISFDIAMLEIFLPLICGATVVVAQKAETRDPRALMS MIKRHSITIMQATPATWQMILESGWHSDVHLSTIICGGEALPQKLANRLLSCAESVWNV YGPTEATVWASMWRVCPDQPVVIGRPINNYRLYVLDNNDLSRVPIGTEGELFIGGASLA RGYHKKPEITQERFIHNPFHPGLMYRTGDLARFDSLDSLRVLGRADGQVKIR" CDS_motif complement(26466..26555) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0003" /evalue="6.80E-13" /label="NRPS-A_a6" /locus_tag="EJ05DRAFT_532754" /protein_end="389" /protein_start="359" /score="40.8" /tool="antismash" /translation="PIGTEGELFIGGASLARGYHKKPEITQERF" CDS_motif complement(27057..27116) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0002" /evalue="4.60E-10" /label="NRPS-A_a3" /locus_tag="EJ05DRAFT_532754" /protein_end="192" /protein_start="172" /score="31.4" /tool="antismash" /translation="AYVIYTSGSTGKPKGVEISH" CDS_motif complement(27306..27347) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_532754_0001" /evalue="5.40E-06" /label="NRPS-A_a2" /locus_tag="EJ05DRAFT_532754" /protein_end="109" /protein_start="95" /score="19.4" /tool="antismash" /translation="LAVLKAGAAYVPID" gene <28563..>29848 /db_xref="GeneID:54487210" /locus_tag="EJ05DRAFT_493994" mRNA join(<28563..28658,28731..28944,28995..>29848) /db_xref="GeneID:54487210" /locus_tag="EJ05DRAFT_493994" /product="l-allo-threonine aldolase" /transcript_id="XM_033746156.1" CDS join(28563..28658,28731..28944,28995..29848) /NRPS_PKS="Domain: Beta_elim_lyase (49-330). E-value: 3.9e-60. Score: 195.4. Matches aSDomain: nrpspksdomains_EJ05DRAFT_493994_Beta_elim_lyase.1" /codon_start=1 /db_xref="GeneID:54487210" /db_xref="InterPro:IPR001597" /db_xref="JGIDB:Psehy1_493994" /locus_tag="EJ05DRAFT_493994" /product="l-allo-threonine aldolase" /protein_id="XP_033597927.1" /transl_table=1 /translation="MAPGITLDNAVEDFVFTKTAGSEKNHATVTETLDLSSIAWAHCRE SSNNFISDFYTKPTLPMLEAIIRTTLDDGDNDEDATTNDLQDYVAGLLGHESALLVPTG TMGNQVSLRTALGNPPHSILCDYRGHIMHFEGGGPSGICGTLVRSVVPANEHHLTLADV QRFATLRNTMYDCPTRVIALENPMEGRILPLSDIQAISNWARERGIHMHLDGARLWEAV AAGAGSLEEIGKCFDSIQVCFTKGLGAPLGSMVIGKKDFIARAKWSRKLLGGGTRASGV IAAPARVAIDDVLFGGKMKAAQDKAQRASELWTELGGKLLERRETNMVWLDYEGSGVDM EGFFKLAKEEYGLKLGGVIPERLVFHYQISDESFEKLCALFRRALAK" aSDomain join(28782..28944,28995..29674) /aSDomain="Beta_elim_lyase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EJ05DRAFT_493994_Beta_elim_lyase .1" /evalue="3.90E-60" /label="EJ05DRAFT_493994_Beta_elim_lyase.1" /locus_tag="EJ05DRAFT_493994" /protein_end="330" /protein_start="49" /score="195.4" /tool="antismash" /translation="FISDFYTKPTLPMLEAIIRTTLDDGDNDEDATTNDLQDYVAGLLG HESALLVPTGTMGNQVSLRTALGNPPHSILCDYRGHIMHFEGGGPSGICGTLVRSVVPA NEHHLTLADVQRFATLRNTMYDCPTRVIALENPMEGRILPLSDIQAISNWARERGIHMH LDGARLWEAVAAGAGSLEEIGKCFDSIQVCFTKGLGAPLGSMVIGKKDFIARAKWSRKL LGGGTRASGVIAAPARVAIDDVLFGGKMKAAQDKAQRASELWTELGGKLLERRETNMVW " PFAM_domain join(28782..28944,28995..29674) /aSDomain="Beta_elim_lyase" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01212.24" /db_xref="GO:0006520" /db_xref="GO:0016829" /description="Beta-eliminating lyase" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_493994_0030" /evalue="1.40E-57" /gene_ontologies="GO:0006520: amino acid metabolic process" /gene_ontologies="GO:0016829: lyase activity" /label="EJ05DRAFT_493994" /locus_tag="EJ05DRAFT_493994" /protein_end="330" /protein_start="49" /score="195.4" /tool="antismash" /translation="FISDFYTKPTLPMLEAIIRTTLDDGDNDEDATTNDLQDYVAGLLG HESALLVPTGTMGNQVSLRTALGNPPHSILCDYRGHIMHFEGGGPSGICGTLVRSVVPA NEHHLTLADVQRFATLRNTMYDCPTRVIALENPMEGRILPLSDIQAISNWARERGIHMH LDGARLWEAVAAGAGSLEEIGKCFDSIQVCFTKGLGAPLGSMVIGKKDFIARAKWSRKL LGGGTRASGVIAAPARVAIDDVLFGGKMKAAQDKAQRASELWTELGGKLLERRETNMVW " CDS_motif 29150..29287 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EJ05DRAFT_493994_0001" /evalue="9.20E-02" /label="C67_DCL_14fromHMM" /locus_tag="EJ05DRAFT_493994" /protein_end="201" /protein_start="155" /score="5.1" /tool="antismash" /translation="HHLTLADVQRFATLRNTMYDCPTRVIALENPMEGRILPLSDIQAI S" gene 30607..32434 /db_xref="GeneID:54490145" /locus_tag="EJ05DRAFT_532756" mRNA join(30607..31024,31091..31191,31243..32434) /db_xref="GeneID:54490145" /locus_tag="EJ05DRAFT_532756" /product="MFS general substrate transporter" /transcript_id="XM_033749091.1" CDS join(30760..31024,31091..31191,31243..32307) /codon_start=1 /db_xref="GeneID:54490145" /db_xref="InterPro:IPR011701" /db_xref="JGIDB:Psehy1_532756" /gene_functions="transport (smcogs) SMCOG1137:Major facilitator superfamily MFS 1 (Score: 171.5; E-value: 3.9e-52)" /gene_kind="transport" /locus_tag="EJ05DRAFT_532756" /product="MFS general substrate transporter" /protein_id="XP_033597928.1" /transl_table=1 /translation="MVYRPSEDKSHSSIYLHDVRIASSTSTNNASKASQSTIVDAEHQF GESESVPNNGIEGFDYSTLPPVDTGKDAWLCLLAVFTIEVMILGYGFSYGVFQDFYAVN EPFASSSSNSSVIGVLTTGILFLTTPIFLPLCRHYPQWARWMATFGVFLALISNIASSF CTKIPQLIGTQGVILGLAGGLAFCPCLVYIDQWFDKRKGLAFGIFGSGAGFGGVFIPLM LRAMLNNVGFATTMRIWAGIHAGIGLTAAYFVKPRLPPAATLTRPFWNPRALRSRFFLM NQLANTIQGAGYYLPGIYLPTYAREILGASAWPATVSLMIFNISATIGLILMGHFTDRF TSRTCILVSSLGSTIAALIVWGLTTHIATLYTFSILFGLFSGSWPAVWPAVMRETARRG EERGFGYVDTLMVYSLLCVGRGVGNIVSGPLSEALTKDMPWKGAVIGGYGSGYGALILF SGLTSLVSGINTLWYQKL" PFAM_domain join(31123..31191,31243..32061) /aSDomain="MFS_1" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF07690.19" /db_xref="GO:0022857" /db_xref="GO:0055085" /description="Major Facilitator Superfamily" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532756_0031" /evalue="4.60E-16" /gene_ontologies="GO:0022857: transmembrane transporter activity" /gene_ontologies="GO:0055085: transmembrane transport" /label="EJ05DRAFT_532756" /locus_tag="EJ05DRAFT_532756" /protein_end="395" /protein_start="99" /score="58.8" /tool="antismash" /translation="FYAVNEPFASSSSNSSVIGVLTTGILFLTTPIFLPLCRHYPQWAR WMATFGVFLALISNIASSFCTKIPQLIGTQGVILGLAGGLAFCPCLVYIDQWFDKRKGL AFGIFGSGAGFGGVFIPLMLRAMLNNVGFATTMRIWAGIHAGIGLTAAYFVKPRLPPAA TLTRPFWNPRALRSRFFLMNQLANTIQGAGYYLPGIYLPTYAREILGASAWPATVSLMI FNISATIGLILMGHFTDRFTSRTCILVSSLGSTIAALIVWGLTTHIATLYTFSILFGLF SGSWPAVWPAVMRET" assembly_gap 35709..35718 /estimated_length=10 /gap_type="within scaffold" /linkage_evidence="paired-ends" CDS complement(join(36892..38052,38108..38374)) /codon_start=1 /db_xref="GeneID:54489439" /db_xref="JGIDB:Psehy1_512987" /locus_tag="EJ05DRAFT_512987" /product="uncharacterized protein" /protein_id="XP_033597929.1" /transl_table=1 /translation="MYRLATFAALAGSVLCKEKPKDFSIAADKYDSGTMHMEIMATKRG TFQRQRDSGAMNSEQYIELPFANCRDGKAQPFRNNATLAFRCNNLNLHHFLSHAALGSA TGEGSSSWGWTSDDGREFIAIAQADGAAFAQVTTAGKLEYLGRLPKTSAAEPEIWREIR GYNNYMIIGSEAEKHNIQIFDMTKLLDLDNRNPVTFNPDTDVTGIFTDLPIGRTHNVVA NPASGFAYSVGAAPRTDKCRSGLIAIDMSDPAHPTSPGCAAIDGYVHDAQCLMYKGPDA KYAGREICYGYNEDSLSIYDMSDKLDPHLVSVTSYDGAAYTHQGWVLDPDWQEYLIMDD EYDEFDRVGPAADGHPVTYIWDISELERPRQTGYYKSTAYSVDHNQYIAGKYAYQSNYG SGFRILDVSSIPADPTGAGVKEVAFFDVYPEDDAEPNGGVIDFVGTWSSYALFESGFIV VNTIERGAFVLKVQSLG" gene complement(<36892..38760) /db_xref="GeneID:54489439" /locus_tag="EJ05DRAFT_512987" mRNA complement(join(<36892..38052,38108..38760)) /db_xref="GeneID:54489439" /locus_tag="EJ05DRAFT_512987" /product="uncharacterized protein" /transcript_id="XM_033748385.1" aSDomain complement(join(36910..38052,38108..38140)) /aSDomain="TIGR04312" /aSTool="tigrfam" /description="choice_anch_B: choice-of-anchor B domain" /detection="hmmscan" /domain_id="TIGRFam_EJ05DRAFT_512987_0003" /evalue="3.70E-94" /identifier="TIGR04312" /label="EJ05DRAFT_512987" /locus_tag="EJ05DRAFT_512987" /protein_end="470" /protein_start="78" /score="313.9" /tool="antismash" /translation="NNATLAFRCNNLNLHHFLSHAALGSATGEGSSSWGWTSDDGREFI AIAQADGAAFAQVTTAGKLEYLGRLPKTSAAEPEIWREIRGYNNYMIIGSEAEKHNIQI FDMTKLLDLDNRNPVTFNPDTDVTGIFTDLPIGRTHNVVANPASGFAYSVGAAPRTDKC RSGLIAIDMSDPAHPTSPGCAAIDGYVHDAQCLMYKGPDAKYAGREICYGYNEDSLSIY DMSDKLDPHLVSVTSYDGAAYTHQGWVLDPDWQEYLIMDDEYDEFDRVGPAADGHPVTY IWDISELERPRQTGYYKSTAYSVDHNQYIAGKYAYQSNYGSGFRILDVSSIPADPTGAG VKEVAFFDVYPEDDAEPNGGVIDFVGTWSSYALFESGFIVVNTIERGAFVLK" gene complement(39218..41181) /db_xref="GeneID:54489440" /locus_tag="EJ05DRAFT_512988" mRNA complement(join(39218..40309,40364..41181)) /db_xref="GeneID:54489440" /locus_tag="EJ05DRAFT_512988" /product="proline oxidase" /transcript_id="XM_033748386.1" CDS complement(join(39469..40309,40364..40959)) /codon_start=1 /db_xref="GeneID:54489440" /db_xref="InterPro:IPR002872" /db_xref="JGIDB:Psehy1_512988" /locus_tag="EJ05DRAFT_512988" /product="proline oxidase" /protein_id="XP_033597930.1" /transl_table=1 /translation="MATMRSQMHAARHFRTLTPTYVLSFSRSVQSSKPRSVALPASPFP SIPPHHAVSKPPITSPLSRLPASDVLRSYVITAMSSSPILLDACLALLTRMLQSKSALL NVDKNPILSWLLKKTFYAQFCAGENRAEIQSTMARIKDLGYKGVILEYALEVLGEKGQS SLSADSAETKAAVEHWRKGALQTVEICAPGDFVGIKWSGLGPYALQLLKQNKPPTPLMH DAITQLCDRASAKGVMLLNDAEEHATNIGIDSWNRALQRKYNTKERGRAIVYTTYQAYD RSTPVNLARDLAEAQKHNYILGVKLVRGAYLNSEPRHLLWATIEETHKCYDELTESLLK RQYGDMLRPADPENTTFPEVELVIATHNAESVRKARAIRDAQAANGEPRIKLAYAQLLG MADEVSCNLLDKTRGVSRPADVDTPFAYKCVSWGTTRECLNYLLRRAAENKDAASRTVG TRRAMGAEILRRVRSVFGAA" PFAM_domain complement(join(39538..40309,40364..40560)) /aSDomain="Pro_dh" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01619.21" /description="Proline dehydrogenase" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_512988_0032" /evalue="3.10E-57" /label="EJ05DRAFT_512988" /locus_tag="EJ05DRAFT_512988" /protein_end="456" /protein_start="133" /score="194.4" /tool="antismash" /translation="QSTMARIKDLGYKGVILEYALEVLGEKGQSSLSADSAETKAAVEH WRKGALQTVEICAPGDFVGIKWSGLGPYALQLLKQNKPPTPLMHDAITQLCDRASAKGV MLLNDAEEHATNIGIDSWNRALQRKYNTKERGRAIVYTTYQAYDRSTPVNLARDLAEAQ KHNYILGVKLVRGAYLNSEPRHLLWATIEETHKCYDELTESLLKRQYGDMLRPADPENT TFPEVELVIATHNAESVRKARAIRDAQAANGEPRIKLAYAQLLGMADEVSCNLLDKTRG VSRPADVDTPFAYKCVSWGTTRECLNYLLRRAAENKDAASRT" gene 42831..>44894 /db_xref="GeneID:54490146" /locus_tag="EJ05DRAFT_532758" mRNA join(42831..43211,43267..43470,43523..43651,43728..>44894) /db_xref="GeneID:54490146" /locus_tag="EJ05DRAFT_532758" /product="uncharacterized protein" /transcript_id="XM_033749092.1" CDS join(42903..43211,43267..43470,43523..43651,43728..44894) /codon_start=1 /db_xref="GeneID:54490146" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="JGIDB:Psehy1_532758" /locus_tag="EJ05DRAFT_532758" /product="uncharacterized protein" /protein_id="XP_033597931.1" /transl_table=1 /translation="MGTESSDQKHPQFGHLPLATSGPQECALTGNALLRNPYFNKGSAF TAEERETFKLHGLLPSNVQTLEEQVERAYKQYCSRQDDLAKNTFMTSMKEQNEVLYYRL IQDHLKEMFPVIYTPTEGEAIANYSRLFRRPEGCFLNIYDMDRIDDNLAQWGAPDDIDL IVVSDGEQILGIGDQGVGGILISIAKLVIYTLCAGIHPTRTLPVVLDAGTNNKAFLQDP LYLGLPKPRAPTQQYNTFIDTFIRSARTHHPNAYIHFEDFGLANARTILDKYTPHIACF NDDIQGTGCVTLAALTAALHITRTPWAHLRVLVYGAGTAGTGIADQIRDAIAVETGREA SDAAAQIWCVDKHGLLLRSDGERLTSAQASYARRDEDWTHTPHTDLLSIVHAVKPHVLI GTSTQPGAFTEAVIRGMTSHVPRPVIFPLSNPTRLHEAQPSDIFKWTGGKALIATGSPF PPVEHDGETYEVAECNNSVCFPGIGLGAVLCRTRLLSPALLVAATRALAAQAPALRDPR RGLVPDVTEVREVSVRVAAAVIREAGREGLSRVGGIPEGEAELEGWIREQMWEARYRGL ELVGRERASRVARGEAGATGSRLARE" PFAM_domain join(43185..43211,43267..43470,43523..43651,43728..43907) /aSDomain="malic" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00390.22" /db_xref="GO:0004471" /description="Malic enzyme, N-terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532758_0033" /evalue="5.30E-64" /gene_ontologies="GO:0004471: malate dehydrogenase (decarboxylating) (NAD+) activity" /label="EJ05DRAFT_532758" /locus_tag="EJ05DRAFT_532758" /protein_end="274" /protein_start="94" /score="215.5" /tool="antismash" /translation="EQNEVLYYRLIQDHLKEMFPVIYTPTEGEAIANYSRLFRRPEGCF LNIYDMDRIDDNLAQWGAPDDIDLIVVSDGEQILGIGDQGVGGILISIAKLVIYTLCAG IHPTRTLPVVLDAGTNNKAFLQDPLYLGLPKPRAPTQQYNTFIDTFIRSARTHHPNAYI HFEDFGLANARTILDKY" PFAM_domain 43938..44711 /aSDomain="Malic_M" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF03949.18" /db_xref="GO:0051287" /description="Malic enzyme, NAD binding domain" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_532758_0034" /evalue="9.90E-88" /gene_ontologies="GO:0051287: NAD binding" /label="EJ05DRAFT_532758" /locus_tag="EJ05DRAFT_532758" /protein_end="542" /protein_start="284" /score="293.9" /tool="antismash" /translation="IQGTGCVTLAALTAALHITRTPWAHLRVLVYGAGTAGTGIADQIR DAIAVETGREASDAAAQIWCVDKHGLLLRSDGERLTSAQASYARRDEDWTHTPHTDLLS IVHAVKPHVLIGTSTQPGAFTEAVIRGMTSHVPRPVIFPLSNPTRLHEAQPSDIFKWTG GKALIATGSPFPPVEHDGETYEVAECNNSVCFPGIGLGAVLCRTRLLSPALLVAATRAL AAQAPALRDPRRGLVPDVTEVREVSVRVAAAVIREA" gene complement(<44970..>46301) /db_xref="GeneID:54487211" /locus_tag="EJ05DRAFT_493998" mRNA complement(join(<44970..46058,46113..>46301)) /db_xref="GeneID:54487211" /locus_tag="EJ05DRAFT_493998" /product="PLP-dependent transferase" /transcript_id="XM_033746157.1" CDS complement(join(44970..46058,46113..46301)) /codon_start=1 /db_xref="GeneID:54487211" /db_xref="InterPro:IPR000277" /db_xref="JGIDB:Psehy1_493998" /gene_functions="biosynthetic-additional (smcogs) SMCOG1168:O-succinylhomoserine sulfhydrylase (Score: 219.2; E-value: 1.2e-66)" /gene_kind="biosynthetic-additional" /locus_tag="EJ05DRAFT_493998" /product="PLP-dependent transferase" /protein_id="XP_033597932.1" /transl_table=1 /translation="MDPHVEEETTASLNSTTHALSTLALHADDILNSTTDVAPALHVST TFRYPENPDDLVPINGDENPTLANPTHIYSRVSAPTSTRLETILSALLHAPVLAYTSGL AAFHALLVYLHPKTVAISGGYHGCHGVLGIYRKLTGCKVVDLFADDEAWDAAGLGKGDL VHVETPVNPTGEARDLAFFVKRARERGAWVSVDATLGPPGLQEPFGAYGVDVVMHSGTK YIGGHSDLLLGVLAVRRREWVEGLGVERVFLGAVPGSMEAWLGIRGVRTLELRVRRQSE SAERLVGWLDGCLRGESQGVKGEDGKGEKEDEEEEAAIVRSCVHSVQHASLQKADMHWL KQQMPGGFGPVFAINMKTAGAARALPSKLTLFHHATSLGGVESLIEWRRMSDEGVDERL LRVSVGIEDWVDLKGDLVRGFRASTV" PFAM_domain complement(44988..45278) /aSDomain="Cys_Met_Meta_PP" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01053.23" /db_xref="GO:0019346" /db_xref="GO:0030170" /description="Cys/Met metabolism PLP-dependent enzyme" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_493998_0036" /evalue="1.50E-11" /gene_ontologies="GO:0019346: transsulfuration" /gene_ontologies="GO:0030170: pyridoxal phosphate binding" /label="EJ05DRAFT_493998" /locus_tag="EJ05DRAFT_493998" /protein_end="420" /protein_start="323" /score="43.6" /tool="antismash" /translation="VHSVQHASLQKADMHWLKQQMPGGFGPVFAINMKTAGAARALPSK LTLFHHATSLGGVESLIEWRRMSDEGVDERLLRVSVGIEDWVDLKGDLVRGF" PFAM_domain complement(join(45375..46058,46113..46238)) /aSDomain="Cys_Met_Meta_PP" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01053.23" /db_xref="GO:0019346" /db_xref="GO:0030170" /description="Cys/Met metabolism PLP-dependent enzyme" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_493998_0035" /evalue="5.00E-47" /gene_ontologies="GO:0019346: transsulfuration" /gene_ontologies="GO:0030170: pyridoxal phosphate binding" /label="EJ05DRAFT_493998" /locus_tag="EJ05DRAFT_493998" /protein_end="291" /protein_start="21" /score="160.4" /tool="antismash" /translation="TLALHADDILNSTTDVAPALHVSTTFRYPENPDDLVPINGDENPT LANPTHIYSRVSAPTSTRLETILSALLHAPVLAYTSGLAAFHALLVYLHPKTVAISGGY HGCHGVLGIYRKLTGCKVVDLFADDEAWDAAGLGKGDLVHVETPVNPTGEARDLAFFVK RARERGAWVSVDATLGPPGLQEPFGAYGVDVVMHSGTKYIGGHSDLLLGVLAVRRREWV EGLGVERVFLGAVPGSMEAWLGIRGVRTLELRVRRQSESAERLVGWLD" CDS complement(join(46751..46943,47001..47107,47164..47333, 47390..47609)) /codon_start=1 /db_xref="GeneID:54480003" /db_xref="InterPro:IPR002130" /db_xref="JGIDB:Psehy1_102858" /locus_tag="EJ05DRAFT_102858" /product="uncharacterized protein" /protein_id="XP_033597933.1" /transl_table=1 /translation="MKTFQSCPSILRNSFLPSSPSSSPFFHATPASKRFFHPSPSNMVV KVFFDVSWVGPEVEVDNAGNVTRKGDVKEQRGRINFDLFDDVTPKTAENFRALCTNEKG FGYAGSKFHRVIPKFMLQGGDFTRGNGTGGKSIYGEKFADENFKLKHQKPFLLSMANAG PNTNGSQFFITTVVTSWLDGKHVVFGEVPDGDVASYKVVRGIEAAGSDSGAVKYPKAPT IDKSGIL" PFAM_domain complement(join(46793..46943,47001..47107,47164..47333, 47390..47393)) /aSDomain="Pro_isomerase" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00160.24" /db_xref="GO:0000413" /db_xref="GO:0003755" /description="Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD" /detection="hmmscan" /domain_id="clusterhmmer_EJ05DRAFT_102858_0037" /evalue="3.80E-42" /gene_ontologies="GO:0000413: protein peptidyl-prolyl isomerization" /gene_ontologies="GO:0003755: peptidyl-prolyl cis-trans isomerase activity" /label="EJ05DRAFT_102858" /locus_tag="EJ05DRAFT_102858" /protein_end="216" /protein_start="72" /score="144.3" /tool="antismash" /translation="KEQRGRINFDLFDDVTPKTAENFRALCTNEKGFGYAGSKFHRVIP KFMLQGGDFTRGNGTGGKSIYGEKFADENFKLKHQKPFLLSMANAGPNTNGSQFFITTV VTSWLDGKHVVFGEVPDGDVASYKVVRGIEAAGSDSGAVK" ORIGIN 1 caccagacag tacaagaaag ggcgccacaa gagcagcgag tctagacagg tacttactag 61 atcttggact cacaatcaac gcttgttggc tatattttgt attacgttgt aacccaagag 121 cctgcgtttg aacttggatc ccatgaatat ggtaccatcc tttgtgtcaa ctggctgaac 181 ttccagtgcc acaggccacc actctggtgg gcagcacttg cacttcccgt acgccgccct 241 ttgcatacat atcgatccgt acagtcttgt ggccgcacct cactgtttca gcgactgcgc 301 tcttctgaga tccttggttt tgatctggaa gacatcaggg caaatcatcg tgggtttact 361 acttagttac taataggcgg cttgagacta cacaaatttg gtgccgccac cgaagcgctg 421 gtagttctct catgtttttg accgatgtgt agcgacgtgg ttgttgagtc caccaagttc 481 tcatgcgata gacaatcatg atacttgttt gtatacctgc cttaggcatc taaagccatc 541 tggcacctgc caagtgaaag aggtgcccaa aatagtttcc ggtgcctccc cgctctacac 601 ccgtaccaca aaaaagggac ctgtgtatat ccctaccaaa ccgcccacgc gacccgcttt 661 ccggactgta atacagctta taaaaggggc gtgagtattg gagttgataa tggtcgtgct 721 ggaaattcta ggtctgttga gcctgagtct gctgaggtgc gttgcaactt cgtgactcct 781 aaatttcctc acgtatatca atttcatttc cattacgaac attcatacga agtctcaatt 841 gcgaagagag taccctctca tcactcatcc cagcccagag aaaccagacg ttcctgctat 901 gcctgcgtgg acgcgtctga tacgcttcgt tgacgaagac gacatcgaac gctacggcga 961 gcccattgtt aactccggcg atgaagtcat cccgctgtac gaagccggta ggcttgaagc 1021 tacggttttg agtggaacta cattcagcga aagtggtctc acaccggaga aaggcgtcac 1081 gaagtttgtc aaagaactgc ttagtccact cacgccgaag gatgtaccaa ttgttagatg 1141 cgtcggtttg aattatatga agcacagtac agtgttgccc gtggacattt gatggtaagc 1201 ttgaactgac ggttgcaata gtcaaggagg gtggtcgaac ggcgcctcca tatccttcaa 1261 ttttcataaa aggatcaccg tctattgcgc agtggaacga gactatccca ataccgccag 1321 tggcgcacac tgatagcaca gattatgaag gtgaacttgt aagttttgct gcaagcacag 1381 atatcctcga tcccatcttc taacccttca gtgttttgtt gttggtcgca cggcaaaaga 1441 tattcctaga gaagacgcac tgtcatatat cgccggctat ctcgtgggga acgacatttc 1501 aaaccgtgca tggcaacgcg atcctgccta cgccggcagc gtaccccaat ggggtttcag 1561 caaaggcttt gataagtacg cgccgctcgg accggtaatc gtgtcaccct cgattctcaa 1621 gtctgcggat gacctgcgat tgcagacctt tgtgaacggt gagctacggc aagacacagg 1681 gacggacgat atgttattcg acgtgacgac tatcctcagc ttcatcagtc aaggtacgac 1741 aatcgaagct gggactgtgg taatgacggg aactccttcg ggcgttggat ttggtttcaa 1801 gcctgagccg aaatacctga cccatgagga cgaggtagaa gtgaggatca ctggtcttgg 1861 aagtgtgagg aacaagatac ggtttgaagg tgcaactatg gcgggagaga cgaggccgac 1921 gaaggtagat actacaccat tagccgagag tgagtgaact atacaataat aatgtgaagt 1981 atacgggttt ttctttgtct gaagtacacc cgaatgtagt tgatgaacgc tttagccccc 2041 cttaatgatg ttaacgccaa agatgatccg taatcattca atgcatcatt gccagtcgcg 2101 atacctttga atatgccggt attacttgag ccggtgtatt taaactatct tttgacacct 2161 tttcctcggt tcaatttcag cgtgaagggg ttgcgacttt gtttcacatc tgaaccgacg 2221 acattagacc taggtgcaat ggtatagctc atatgctctg tctctaccct ggcacggttc 2281 gagcgagcag gtgcggcgag agctctagct ctagctgcag cagcaatcgc ggcttgagag 2341 tttgattgtg agttccgaat aggtaggcgc gttgggtcat aatctgcctg agcaacatcc 2401 ttcttgcgat aatcatcgtt gcgtctcaag ataggtcttg tccaatcggc tacaagcttc 2461 tccgcgtgtc ttttaatacc aggttcggca cgcttggtct tagtgtagaa gtagaccact 2521 ttaccgattc cagaagcagt caaagcatcc tttgtgattg gaagcttgcc aagagcatca 2581 aagagctcgc gttgaatgtt atacgcaggg agactgccgt cgtgtagggg ttctaggaag 2641 aagcaaacag cttggagcaa attgaggtcc gggtcaacga gagagttctg caaagtattt 2701 ttgttaagga gagacaccac ctccggaagt agcttcaact tccgcattgc aggtctacca 2761 tgtttgcggt cctctgcatc attggcggca gcatcggtca ttctcttgcg catatcttcg 2821 atctcggcat ctgccatagc ttcaaggtcg atgccgtcct tcttcctgcg taccttcggt 2881 ttcctctgcg cttcgtccat ggctctgtcc aaagctctcc ggcgtcctgc ataagaactt 2941 agtcactatt gaaggcattt agtaaaggct atacgtacgc tcctctggcg tgagatttgt 3001 atcatcctcc actggtgtag cagcccgaac cctgtccttt ttcctggacc tcttcccttc 3061 aagctcctca ccgccactga agtggtcctc atctcttttc ttcctattct tgggcttctc 3121 tcgcctgccc tccttcttct tcttttgtac tccaccttcg ccatcttcac ctctcttcct 3181 tttactgacc ttgatctgac caagaaggtc gtcatcaaga gccaccggtt gatcctcgat 3241 agcaatgtct gcagggttga agtcttcaaa ctgtgcctcg tctacatcag aaagaacgga 3301 ctcgttgtca gaatcttcgc catccttgtc gacttcattc tctccagtaa gttcaacgtc 3361 ttcttgcggg aaaacctcag gtgcatcggg gttgttctcc tcctctacgt caggccccag 3421 agggtcgcca gggtccgcat tgccttctgg catgacagga gtttggactg tcgcgtcgtc 3481 gggaggtgtc tggatgtcat ccatgtttgc tatgttccgg ggtattttca gtactggaat 3541 caagatagtc gatagaaagt tggaacaagc gctcgggttg gtgagagctt gatgttctat 3601 cgcgaggaga gttgcttagg actactggct gtttgaaacc ttagaaggaa cgcgctggac 3661 atgcactatt gccgcggttt aaccgatcaa ctgctagacc ctggttgcca gcaccagaag 3721 atttcttgct gtcactgtat attcaaactc atcataacaa caacgtcaat actaaagatg 3781 ttcggaggac gtgagttata tgacaggctc ttctctgttg atctctaata tcttgtagca 3841 ccaccagcac caagccaggc ggagctcaaa gctcaagaag aagccgcctc gaatgaactc 3901 aagttcgccc tgagtacgtg cttcgctctc tacctctgta agttacactg ttgcgctctt 3961 gtctttcagt actaatcatg cttgtgaaag ccccgttcgt catcgactac gtccgaaaat 4021 tagtatagat gccacacgcg aacgcttctt acgtcgagca tcgatgaatc gcagtccaag 4081 gtccttccat gtatcataga cttcatgacc tcacttgtac tatataggat gcttcgagac 4141 actggaagca tttcaggttc ataattcccg caattgtaca ctgcagctat ttatacataa 4201 tagagcgcaa tcttagggcg atagtggcta cctgccattc agactgtttt gtgacttgcc 4261 ctgccaatcc tcaaactcta acttcaaaga tccaacctcc ttctccagat gatccagttg 4321 tgacttatag tctttcaata tctactgatg ttagtcagat tcggttgggg aaaacgaatt 4381 tggaccgacc ttctcgactt gcttcatctt atcagggtcc acaccattat ccccatctga 4441 gacctggttt cccaacttct ccgactctga ctggagccac tgggcttgtt gcctgagggt 4501 tgaaagtctt gcccagatct cttcttgacg accgctggct accggatcaa aggccttctt 4561 ctctagctca atcaatttct tcctcagctc ttcctcacta ctctccatag cgtatcctcg 4621 attgcgaaga acctgcacct tggtcgcaag ggccagtgca cgctgactca atgctatgtg 4681 cctcctcttc gcttcggcga tcttgaccgt ccattctagc tcatgcttct gcatcatcat 4741 attcaagcta ttgttgatct catggagacg tacttggagg gcttgaacag tcgatgactg 4801 cagagagaga cgcgtgccca cttccttaaa gcccttcgcg agtacgggta ttgaaccttc 4861 gcttggcttc ttcgaaagcg cctcctccca ttttcgctca tcttcaccag gacctggtgt 4921 atagaagggc actacacgcg gatctacgtt attgtaaaaa tagtattgaa ataggcaatt 4981 tggcgattct gggtgccatt tctccaagat tgtggacagc tgttctggta cagacttctc 5041 tcctgaaaca ctcattagca cgactctttc atatcattgt agactactct tacttgggcc 5101 ttgctgcggt ggctcccaaa tggcactttg tcctagtttt ggtaattgcg atgtcgagtt 5161 tccaagctgt gatccgccaa attgtgacgc atacaagctt gcttgttgct gtggggtagg 5221 ctgttgctgc tgctgctgct gctgttgttg ttgttgttgt tgttgttgtt gttgttgttg 5281 ttgttgttgt tgttgttgtt gttgcgattg cccaagaccg ccgaacaagc tgggacgagg 5341 ctgctgctgg ttttgttgct gtgaagctcc taatgatcca aagagaccag tggattgctg 5401 tgcaggctgc tgctgagtag aagccccaaa gccgccgaaa gggttcggct tcgccgcaga 5461 cgctccgaac attgtatagc tgaattatga ggtcgaacgc gaaggacttc gatgtatact 5521 tggcgatttt caggtccagt aacaacgagg caaatagcgt ccagagaaga acccttctgt 5581 gcgcatcagc gtggtgtcat tatgtggtgt cgatgcgtcg cgtgcagatg aatctgaaat 5641 gattgtttgt tctagctggc gatgttcctg atctgcgcga gcttgcagcg caccaatcac 5701 aagcaaggag atggatcctg cgtcttgttc aagctccatg tccaacctca cctctcgaga 5761 ctgccatcgg tctcccagga cgtaaatgcc caacgactac cacaatgtcg acacgcgtcc 5821 caaggtacgc gatcatattt atttcccaaa gtcaattgtt cgctaagccc caccaggttc 5881 aataaaacgt cactatatga caccacccct ctccccgatg atatccccaa ggtcaaagag 5941 atcggtgcga gctcggcacc attgatgtcg gctgccttct tcattggagc acgatgcaaa 6001 gcatacaatg atgactatat gcagtgcaag actgagtcaa acggccgcgg agagctcgaa 6061 tgcatgaaag agggaagaaa ggtcacaaga tgcgctgcga gcgtgtaagc aggcctgtac 6121 aaacatacaa ggagacgaac atcgatcgct gactgtgact cctgtagact ggaagatata 6181 aacaaaaact gcttggaaga gttcaaaaag cactgggact gcctagagaa caacaatcaa 6241 cagctatggc attgccgagc gcaagagagg ccattcaaca aatgtgtatt cgataagctg 6301 gtaagatcat gacattttcc ctactattaa catgcaaact gacgcaatgt atagaacctg 6361 gagaagacca ttccaggaac accggaaaat gtcacacctg tgcatctccg caaataccag 6421 aaattctctt agatcgagta gcaagaagaa tgtcacattt tgtacaacat cagactaata 6481 attcggcact ttgaccctac ccttgagtac ttacacagtt tctaggacac gtgaacagct 6541 ggaacttctc ccatagagca cctctgcagg atcagggcag aatgacgcgc agattccccg 6601 ggtgaccttc acctaacgac cagtggaatc atcatctgtg cccatgatat ctgccagcat 6661 aaacaaccag aacgactaga gctacgtgcg atactcgacg cccaattgca tcatccgaag 6721 cagagagttt atcgcactgt aggtttgcta gatatttagt gtctcttatc acgctagaaa 6781 cacaagcccc gacgcattct gtgcatctat gaatctcttg tgtctttcct tcattctatc 6841 cactagatct accaatacta tctcgtggaa gtttttatca gcgtcacgat atttcgaact 6901 accaggcgct atcaccttca tccgctactt cgtaatcatt tccactcagt ctcaacggtc 6961 atggcagaga ttagccacgc catttcttgt tacacctttc tttggggatg atatcattat 7021 tcagctgcaa ttcccagaat tttcgcgatg agcatcacca gaagtccacc caccatctct 7081 gaattggggt gaaaggttca tatgaaccat gctagagaat acgacatgca ggaacatgtc 7141 tcaggaagtt cctagttgta cgatgtgata tacatcagga ggggaagccg tgaaggacgt 7201 caagagctac actaagtata tgcaaacagc gtcaattata ccggaagggt aggtggagag 7261 gcttggccga gactctatag tcgttcctca gacttcgtgg cgtcaatttc cgctgaagcc 7321 tgaacacgca cttggtactt tcatgtcaga tcgctaatgg accttgacct gcctcactct 7381 tagtaagtgg ctgttgtcga aatgcacatg agctcgcttt gttggagttc gtgggactct 7441 gcttatagtg gaggcaattc ttgatggtga cgtctagcat ctagcatgca tgagattcca 7501 caggattatg tgtgaacata tgagtcattg gtatctagat catgtacgtc ttgtatacag 7561 catcagaaat cctggcgcgg acatggacgg cttgtgtgaa gagtctacag tgtagaaatg 7621 gatcataact acttcagccg ttctcttcct agcgcaccaa gtacgatccc gagaaaccaa 7681 gcgacgcata cgacgccgta gatatgatct ctgacccata tttgccattc aggacgctca 7741 taaaagctca ttagaagcca tgctaccaca atgcggcctg cacgcagcag cctaggctgc 7801 gcgacgacaa gtatgccgtc tcgtagaagc gtaacccata agacatcgat caacccttct 7861 ctccaggtca tgcttgtttg agagaaggcc atgacgtatg tgaaaaagct tgtaagctcc 7921 cattgtcggt acatgatgct ggtgccgaat gaggcacgaa tgtgtttgta gagcgggtcc 7981 acgccagcaa gggcttttgg tgtagtattc cacattcgat aatagattcg agtcgtatta 8041 ttgttgttta tgtgtgctgc cagtaaaggt gcactaatgt agaccaaaca acttcgaaac 8101 caaaccagag gagtgcgacc cacgggtagg ttgaagatgc catagagatt gaccattgac 8161 gttatagaat agttgaaatt cgaggagatg aatgagtccc agatggtgtc gttcatgagg 8221 atattggaaa tgtcccagcc aaagattacc aggaagcagc catgcatgag agggaccaaa 8281 agagtatacc atatgtacgg ccataatgtg ctgcaatcta tggtgtccac tttggccacc 8341 cagaatgact cgctaagtac atcgtcctta ttgagggtga ccctgaatgc caatttattg 8401 ttggcccata cgaattttgt caatggaaga ctgtgtatta aaggatcttc tttgaagcga 8461 atcatggtag caccagccgc attttcgtgg cctgtatccg gaggttcccc ttgatgttgc 8521 aacatttggg tgtctctgtc atcacatgca tgcgcagcga tacgcacggc aggaagaatc 8581 tgataattgc catccataga tgcttcaatc ccgtgaacat cagcaaaagt ctggcgcgta 8641 tctggaccat atttaaacat aacatgtaca tcatatgtgg atgctacgtt atttctatcg 8701 atgtgaggga ccctcaaatg tgcatccata cgtagggctc tgcgatcacc cggatccgaa 8761 acaggttgac agaatttcag ttctttgttc caaaatgctt gcgggtatgc tgagtgaatc 8821 caagcctccg gaggtggcgt acctgattgt gactgatgac gtcttgtcca cgaaggtagc 8881 tcaaggcgta attttgtgtg tcgcataggt ttcgtagccc caattagctg ttcaacttgt 8941 ccaagagctg gcgctagatc tgcctctcgt cgaattacga ttttgcgccg gggaggcttt 9001 tccactttct ccttctttcg gaactcggac caatcaactt cagtacagcg gccttcaggg 9061 gtaggaacaa cacaatattc ctctggaccg gatggttgaa gattcaaaag gaatactgaa 9121 aaaggactgt tgaccgaccg acagtccaga aggaccctat aacggtcatg cgctttggtc 9181 tcctgccaaa agtcaaacgt gcggtaaccg ggaagatcta tctctagccc acggttactc 9241 atatagaacg ccgtaggtgc tgaagacgta tttcggatga tgtgtcctct gccttcaaag 9301 tggtctggcg atggagccag gagtaaagct ataccacttc ctgggtatcc cagaagtccc 9361 tgtccacctg cttgcagcga gggcgacgcg tcgttccacg caaacaatga ttggtcgtct 9421 gaatacttga taatttcctc ctggagacgg acaaaagcgt tcttaccacc ctcaccataa 9481 tgtgtcggca tcgtgattcc aaagattcca aacaaagagt acgctcgatc ttctgggcga 9541 gaagtacacc tgccagctgc ccacgacatt ctcttggcta cactgtacgc agaaagatta 9601 tttgggccat cacgcaggac ttcctcgtct atacttgtta cccgagaaag atcacaggca 9661 gagtctgcac gtgtgctcag caggtcccat gtagcatcga agaagatgac tgatttcgga 9721 gcaatgagct cctgtagtgt ccagccccga gtggaccagc gggcttttga gaagtctatc 9781 tgactaggcg ttgccgtctt gaaaacgtct tcgagataga cgtaacagac ggttgctttg 9841 gcgtaccact cgaacatgga gttgatcgaa gtggtcagtt cggtaggatt cttctggtcg 9901 atgcagcatg tgtcgatcca gacgtactcg agcccatcac gtacggcttg agcgacggtg 9961 ttgctgacct tactccatcc tcgtcgacct ttgaggagag cattttcctc atcactgcgc 10021 agagctatat cacgtatatc tggatagtag acttcttcgc ttgcttcttg gatccatgtg 10081 tgtgatagaa ttgcatactt tcgatcaggt gtcccgtcct cgaatagcca gtccttaacg 10141 cgcaaaagtc tcatatttga cttggagact ttccgtgaga ggaaagctag ccgcgccaga 10201 cggcttgcag tgacctttca cgttatatct atacaagaat ttcaaagggc catggcacat 10261 agcgggcaga gtctagacct tcgttcaagt cgagattggc tcctcgtgac agccataggc 10321 tacttgagca agccacagca ccgacttctt cagccgcacg ctcatgttgt gcatggagtg 10381 ctcgagggct tccagaaggg ttccacctga gtgacctacc taagagacct ttgctgacta 10441 aaacttgcta agccactgac ctgacagacg atctcgacct aattaccgcg aaaaagtatc 10501 gcctgaatat gacaccccaa aacaatgtag gcgcagtgag gtaaagatga ctgatcaagc 10561 ggatctacaa gtgtatgagc agctactgca atcgtatgaa tagccaaagc taaacatttt 10621 cagcgttgga cgcgacgccc tgcgctccgc cgaatcctct cgatcgccgt ctccagatca 10681 cgataattgt gcaaccaaca cgtttcgaga actcttgaat aagcgattcg gtgccataga 10741 agatatagaa attctagata cacctcctgc attctcagcg gtagacgttg gtgatgacat 10801 cgaagacact gaattacgct tgttcgcatc gcaaagtgca cctacgaaaa ttgatctccg 10861 ctccccctca ccaccaggtg gggaaccagg gttcgtacaa cccgaaaggc ctttgagtta 10921 ctatcttgca gagtcaccgt cggcacaaga ccaaataagg ctggctctag cagctgtgtc 10981 tggagaggaa gttctcgatc gctcacatgc gagatgggcg ggttgcgcgc tgccctggag 11041 ggtccacact gtaatccccg aaactatact tggtaccaaa atacatatga gtgaattgca 11101 gaggaggaga cgtccatcca agaaggctcg cattgcgctt cgtgcaaaac aaaaggcgaa 11161 actaatgaag gaagaggaag ctaagagagc agcgcaagag aaagaacaat atttaaggga 11221 gaagaagagc gcggaaaata gaaagaaaca attgaagaag cgtgcaaaag agagagcgaa 11281 gaaagccgag actgggatcg ctgcacgaga tatatcaatg tcagcagatt gaagttctac 11341 tctcaatgtg gtcgacgacc tcgactctac ctagagatga tatccgctcc gacgaggtga 11401 ttaaatgcgg tcgaattctt aacttgaatt accagggccc aatttcatcc cgcttgattt 11461 ccatccaccg tcaggaggtg gccagaatca tcgcatgtga gctttgataa catggtcaga 11521 atagtggcac ccgcctcctg atttgtggca cactttactt tcacgtctac gtattggtac 11581 acaacactat tgtagtgcgc tctcccggcc tttcttcgtg cacataagct cgtaaggaga 11641 accagctcaa ttcaactaag agtcattgag acaacgttat cactgaaaag attgtcatat 11701 gcgaggcaat ctgccaagtg atagtcgccg agcttctgaa taggaaaatc tctattgaag 11761 gtgtgttttc gtctcgttta ggctactcga tacataccat ggagtctttc gcattgttca 11821 caaaattcac gcaatgaaat ccctgttcac ttcgtctccg tgaatacggt ttcacctcct 11881 aactcacacg agttctcaat agggcatcat gtcaatggaa attatataga attgagctgt 11941 ggtgaatagc gtaggcctct tgcttgcata taaatacagc ttcaccctgc ctctacacaa 12001 gtttttcttc tttgtctaca aacctgatcc gctgctgtca aacatcaact ttcatctcgc 12061 aagcttgcac tttttcacac ttcttgcctt catcaagtcg acatctctca tatccaacgc 12121 gccgaatcgt cagaacaaac aatcagcaag atcaaatcct tcactaccat catgttccca 12181 gcacgaatct cccagttggc cctcttcatt gcctccgcca ctgccctctt caagcagtgg 12241 tgcatggcct accggtaccc ccggacggtc tcatatgccg atctctgtga ggatacctgc 12301 gtggtcgtca gccagatcct ccaccacttc ttcaccgccg ccgccggctt cagtatcgag 12361 gccaagggaa accttgagca ccccgtccgg gtacgcctca ccaaaaagca caagaaaacg 12421 accattcccg ccgaccagat ctacgaatac cacatcaagc actacaaccc ctctctcgtt 12481 gcgccgtcct gggctggtcc cagcgacatt tcctccttct gggccctggt gctcgccatt 12541 gcctccccgc cgcaagtgcg cgctctgtgg tgccccgaca ccaccgacaa cgagctgcac 12601 gcgtatacca agcgcgtcat gacagaggag ggagtacggg ctggtcccgt actcatcatc 12661 aacaacgaca agatggagtt cttctggttt tctgctggcg ccagtggcgc atactgctgg 12721 ctcgaccgca ccagcttcgg cgtcccggtg gatccgtcgg tgcagctggc tcccggccgc 12781 ctcggccatg tggaactctt gatgcgcggc ttgctcaagc aggagacatg gttgggtgtc 12841 ggtcgggggt tcagtggggt gagggtgggg gagaagggta gggtggggac gaggagtctg 12901 gatgtcagat gtcctcatcc ggagaggacg tgggctttgg aggttggggg tgaggagaga 12961 aggggtgagg cggtgctgga gagcccgccg atgagcccgc tgacggaggt gggggaggag 13021 ttggtggaag agaggcgtgg tgaagagggg gggaggaaga ggaagagaga ggtggaagtg 13081 gatggaggcc ccgatgggga gagggcggcg aagagggtga ggtgggagtg aaggggtggg 13141 agaggtggac tctctacccc agtgaggggg gttcagcggt tggtaacgag aaaagttctt 13201 tgatttcgaa taccacaatg atgattcctt cgccagcgct gctggctata cccaaaatta 13261 aggtctcaac cttgtgtctt agtgattatg ttttgatcat ggtcttcgag tctaagctat 13321 catcttcctt tactactaat catgttaggt taagataact aaaggattga ctagactact 13381 caacgtacta tgacatcctt tgactagcag tatcatggaa acgacaccca gcacattatc 13441 gcatatttcc atgaactgga tatagcctga aaataactag agaatgtagc tttcacaaat 13501 tgttatcact atacatacct tatggttgac gcggcatcaa ggccttttac ggtcatatct 13561 tagtcaattg actgtcgaaa tcatgttata tttcatactt tgagcgttct aacctcctgg 13621 ctatgttatg aaatagagtg tcaatgtttt taggtgtcgt tctcccttgc gaaacagtcc 13681 gtgggaagaa actccactac gggactgcgg gattttgttc tgttggctac ctgccagata 13741 tagcttctag cacatacttt acgaagattc actccatgtt agctccaaga tgatgtgctc 13801 aagcatcgaa ttttgataac atcatgtctc ctcaaatagt atcgaaactc ctaaagctag 13861 ctttaggtct gagctagcag acgttcctcg tccattttga atatctgttt gtctgaaact 13921 ttgaccagca cagctttcag cagacagaga atgtcataca gcatcactcc tcctcctcct 13981 ctgctactga tggcggcgat ccttccgaga gatcaagaga ctctggtgtg ctactaagcg 14041 agctcacctt gtcagaattt gcatctttac cggagtcaag tttcgcttcc aggaggcgga 14101 tggtgttcat cttcctatct ggatagtagc cacgccactc ataggcaaca ataagttcgt 14161 agcatagacg agatcgtgga ccaagtgtgt tgttcatcgg ttccgccata atgttcatgt 14221 gatgggtgtc tcgatcaaac tcttcgtctg ggttccagta cacgaggtcc gccagtacag 14281 acccgcgatg gaaatgagta gccatgcggt tccagccggg gagttctgcc gggctcctct 14341 ctgcgtttat cccgctcaga agattcataa ttccgcgatc caaagccgcc catgcgccat 14401 cgatcttgct gaatagagaa acatctgggt atttgtaaaa tggtgaagcc ttgtcatagt 14461 taatgtcatc atcgccatct ctcccatgga gataattttc tagtaaggtg tgaggtaggg 14521 cttccgctga tatataagaa agcttaccag cattgatatc ttgcagtaga cagacaacag 14581 cataccatat gaagataagc tgctctattt cggtaccatc tcccagaaga tcgctacccc 14641 gcgcacgcat ctttgtcaga atggtctgca atctctcatg gagaaacccc tcgtcctgac 14701 cgttcggtag gagacaagtg cggaccgtat cccattgcgc gttgatctct cgctgtaggg 14761 gtatgtcgtc aggattggag agtggcatat gatactgtcc aaactcgtcc tcttcctcct 14821 gtatgcgatt gattttctgg atcttgtcag gctgggtttt gttggtaagt ctctcaatca 14881 aatttgcgat cgtttcttcg agaacgtcga gggacgccga cgtccactca ctgtgccttt 14941 cctctgaagg catcagccac tcaggcggtg tggatgagct tctgtctgac atggtccagg 15001 caggaagaga tacgaagata tgtagagtag cttgctaatg tcggcacaaa ctgttgaaga 15061 tgttaaggag acttgggatc cagcggtata gatcgttcaa ctcttctgac tgcattatat 15121 actgattcta gcaggtgtca taattttgtg atcttttgtt agatcataga ccgtatcaac 15181 cggtatcggg aagctcttcc attccaagat agcagtacaa gtatcgatcg ttcaatatca 15241 tcatattcga tattgcaact cctgctcgag aagcattcct taggtgatgt ccaacgttca 15301 gttccaatgt ggacaaagct cttagcttct tcgtgtcaca ttccggctct agtgtgcttc 15361 tgatggatgg aatgttaaaa aaagtcgcca catcggatca ggcttgtgtg tccgaccgct 15421 ttgtccctga gatatacaat cgtgttgaac agcgtaccgc acaggaccca acattcctga 15481 cacatcccaa cagcttactg ctggcattct tgtgaaacaa cctactattt cccagagctg 15541 cagtcagcga attcaaatat caagcgacag ctccagtctt cgccctgtag atgagagaat 15601 tatgttacgt tgttgcctag aaagccacag actttcggaa gggcctcata ccacgtactt 15661 aaaactggct gaatcgctcg ccaccctttg agatcctttt gtcgtcatca tgcgccataa 15721 gaaggaataa acttgtctgc gtaattgtta agagcgagcg aagcttgggc taatcgcgat 15781 agctgattga taagataatc aatattaata aacgttacct ggtaataatt agaagtattt 15841 agtgtgcttt cttacttact aatatattaa taagatactc caatcatcag agctttttct 15901 gtcatctatt tatcttatta ggcataagct atttatttag agaagggtct acatagctga 15961 tccggctagc ttagagaccg agtttaacat gattagctac ggtgaacttc aaggtgctac 16021 tggtcttcta gtgttagagg ctcggtcggc agctgtgatc ggataattaa tctccgcacg 16081 ctttcagacg gtccgttcca tagtcgcggg gtaatattag agcgaacggc cttgcctcat 16141 tgggacttgg tacggtagta acagtaagcc gcggtgcaac aagctggcca ctatttctga 16201 ggcgcctatg ttggctggaa aatatgaccg gagtctttgc atcaataaca tcaaccgaac 16261 atgcctagat ctgatgtcgg aaacactcgt gttttcacat actagttcgc cagatgtacg 16321 aaggtgtgta tacattcaga gcttgtacaa tgatagctgt agtcttaggc acattgatct 16381 ataaactttt gtaatcttag agagccctgc agtgctccct cgctcgcact gacatccttt 16441 tgaacatgtc catgagttgc tcaacttgcc tctgtaaatc ctttgcatgc aatccaacgg 16501 cgtgataaaa gacttcgctc ttcgccataa aaggcgatcc ctgctctgta gttaagcttt 16561 caccactatt ttgagtgcct cgtgtcgagt ttggagatgc tgtcgatgag ccgccccgca 16621 ctgtcgtggc tcgtgcgtcg acaggaatct ccaggaggtc ttccgtttcc ccaagtgatt 16681 caaggagcag aagggctgca cttttaatca actcgccgtg agagcagaaa catactttat 16741 gcagttgggc gaggcgaagt ccgcgataag aacgggtttc cgcaagacgg ttaagtggtt 16801 gattgaggct aggatcttgc gataacgaag tgacgaaatg gcgaaaaatg aatgtatata 16861 ttcgatagag cgtcacaaaa caggacagga ctagcagaat cgttggagtg cttagtgcgg 16921 atatagcact ttcttgagat agtattcccg tgggcaaaag gatacttcgg aacagctgag 16981 agaagtacag agcatcacca acggggtatt ccagcgcatc ctttactggg agtcgtgcaa 17041 gttgctgctc gtatcggtac atctcggcaa gaaggttggt gagatgcaga agaggatcca 17101 cgcttccgtc ttgttgctca ttgtcggttg tagattccag atcaattgag ttcccgtcca 17161 atggccatga tttcggcgga gaaccaacag agtcgcttgt ctctgccctc gcagggtctt 17221 caataggaga ttcggctggc tgggaacatt ctaacgatga agggtcgctg tccataagca 17281 ttgactcatt ccaggagtct tgtgccaata gacctcctaa attagcttcc caatatgttg 17341 acacaagatc ggtggagcct ggtggcgcgg cgtatgcttc gtccgagttg aacaactgcg 17401 ctgtcccgtg agtaggtgtt gatgtgaatg attgataagc ctcaaaacaa tctgggctgg 17461 ggttcggcgt caatgcgaac acactcgttc caggaagtgc cgtttctgtg gtcgaatcct 17521 tgcatcttga gatatcgctg gatgatgctc ttgagcgtgc gggccgtggt gcgcgcgagc 17581 gaggaatgaa gacacaggat tctgcagtct tggccttgat gcatcgttga caaggtgcgc 17641 ccggcgtaga gtcagatgta ggaagacacc ggagcttttg gcccctacag cgctcgcacg 17701 aggcgcgaag ccgagtgttg tcacctatgg acattgcgta tcgtgatgtt gattcttcgg 17761 gtaccggagt atatatcgtt cccaaagatg tgagtaattt gccatatcgg agccgtgatg 17821 tcgtcgagcg tgcagagggt aaaccctgtt ttctggttcg tccacagggg ctccgcggga 17881 ccctgcagca ctctttcgtt gcttgtttca atcttaccaa tcatggtatt tggtgaccat 17941 gctgtccctc caagcttcga acactatgcg ggatgtagcg gtgtggtatt gcacatattc 18001 agcataccat gcggtatacg tttctttggt ctttcgagca atgcacccat ggctacgccc 18061 atgtagggcg gcggtggcaa cttcggctta agtttgggca gcgaatgatt agtatcgacc 18121 ccctatcctt tgacattagt gattcaatgc gagcgatctt tgctgtggaa gacaattcgc 18181 tcatgcctgc tcggcgagta atcaggtaag cgctcttagg taaaatgctc ttaggtaagt 18241 gttttcagat gacgtgattg tcggcacctg tgtattggag tgatcagctt ctttgatgct 18301 ttttggaaag aggtgcagct gcatggcatg ggaattctga gcatctttca gcagcagact 18361 agtcaagcca cgagtggaga ggctggtagc gggacatgtt tccgctccaa taacaccttc 18421 ctcgccgcgt ctcatctgca cattcgcgtt gatgagccgc cgcagtgaag gatttgttga 18481 caagaagcta ttccgtgcgc gatcgctgcg atctgattta ataaggtagc agtgtgggcc 18541 ttgatgtctt cgtggcctac attgctctga atacaatacg ggttcaaatt cttcgcccga 18601 tgaaaatatg cagcgacacg tacctctgca gcagcaaact ctatggtttt agctggtcgg 18661 gtatggcgta aatgcatgta tggtctgacc ctggcccgtc gttgggaatt ggaccgactt 18721 gcagtgagac ttttcgttgg cccgctatgc tcaatgaggt aatgcgtttg agtaaccata 18781 gggccgatgc ataaacattc agtctcgctt ggttaatgat ctggtagagg acacgctcac 18841 gtcttcttag aatccaagac ttactttgaa ggttttcata cctgcgagtt tgtccgactc 18901 gttcggaaac gagcaggttt ctgccgcatt tagaacacgt cggcaagcgg cgattctgga 18961 atgctcagct ctttgtggca ctcggaattc cgtatcaccc actcggtaaa tgctaccaat 19021 atcgaagcca aatattacca tcaagaacac tttagctctt gccagtttga atcgtccgac 19081 ccaaccatta cgttctcgct tttgcaatga gtcaaagact tagcagctaa ggccgggaag 19141 atgacagtga cttgtttgac caaagctctt gttgatctgt aacataatag gaaccgttcg 19201 gaactgctac accatgttcg ctcagatgct tggttatgcc ttcctgccca tagcgagacg 19261 ttcgtgctag atgtcggtta ggcaaatgta acggcgtcta attttcagag agcctctcca 19321 tcttcggagt tctgaccaaa atctagatct gaacaggtct cgactagact atcattcaag 19381 ttccagcttg aacggctacc aaaagacatc atgccctcgt gtttctatta tacttttccc 19441 cttcctcagc ccctcaaggc aggtcatgaa ttcaacgttg aggctgttgg aggtactctc 19501 cgttattgat gattgtctga ccatatatga aaaggagacc cagcgcttga ttccaaggtc 19561 gagaagagtg ctcacgcacc actagtgacg ttcatgagct ttatacaatc taagctagtc 19621 gaatgagaat tagcgcggcg cgtctcagta gcttaagcta ctagtagaga cctccgacgc 19681 gtcttctgct tacataatcc atctaccccc ctctcagata tgcatcactc atagatgctt 19741 tcattctttc atttgtccgc ccgtttgtta aggacgtttg atttctatca cgggcttgtt 19801 gctctcccag ccttccatct gtcatttgca tgcccactat ctgttgcaac ctagatcctg 19861 gataaatttt cggccacgaa catgtattaa gttcttcgtc agtcgtttaa cttaattgca 19921 attacttgga aacggcgtac acttgcggtc tgacgtgata tcaaggtaaa gaaacttttt 19981 gatgaacaca ctaaacgctc tcagacgccc gttttgaacc ctcgactgtt gattgtaatc 20041 cgagtcacat aattcctggc cactcgctcg tctatctctg gcaccggata gattttgcct 20101 ccaagcactt ctgggccaac catggggcca gtgacgaatg ccactgcatt cttctcgtcc 20161 tttaccccat caatcaaagc cataatacga gcaagtgggg attctcgatg ggacgcaaca 20221 tgagcaaatg cccgttctcg ccactcaacg aatggcacga tttcttgccc agcactggcc 20281 agactcaata acttccagaa cgcattgaag ctaagaggat ttgcattcgc aaagtcgtaa 20341 tccttgccaa cgctttcaaa atcttgcgtc atctttgtga cgatggttgt agccaaatag 20401 tctacaggca ggactgctgc gagatctgct ccgtccagcg aggggaagaa tcccatttca 20461 agacaaccag agatgaagct gtgcataaaa tcaccccggt ccaaccgaaa gcagccgctt 20521 tcagtcgagg ctgtgacgaa cggcaaccgg tagacagatg cgttggctcc acgccagcgt 20581 gcagctgcaa ccatccgttc agctgtatac tttgaagtag catagccata ttctccgtcc 20641 ccttctacca gctcgaggcc catatacact ggcagagtag acatggtgga gatgaagtgc 20701 actgttttct cccgaccttg tgatgctaaa cgtagtatct catgggtact aacaatgttt 20761 ggaccgagat agtcgtcaag tggacgaacc cagtctacaa gaccacctga atggcagatt 20821 gaatcaatag tctctgtcaa atactggaat tgttcatctg gtaacccaaa cagtggttgt 20881 gacatatccc cgacaatcgc atgaagaagt ggctcaaaac tgggtttcca caaatcatgg 20941 gctgctaaag aatcgagtag ccgttgtcta gcagcctggt cggaaccagc gcgcacgaga 21001 caatgaacag aaatgcccat gctcaagagc tctgccgcaa tgaaagcacc cacgaaacct 21061 gtggcccctg tgacaaatac ggcattgggt ggcttagtgg gttccgtaga tctaaattta 21121 agagttgggt ccagatagcc ttttttgatt gcagctatat caatactcgg tgcaatcgac 21181 tcggatttca cggaagtcgg aggtgtcgaa atatcgccag tgctcgaatc gtctgaatcc 21241 atcatgtctt cttgtaggct ggtgagaaga aatttactca gggcccggag atttggatat 21301 tgaaaggcaa tcctggcatt caatttcaag cccgtcgact tctccagatg attccgcacc 21361 tgcactgctg tcaacgagtc tatgccaata tcttgcaagg cgcgatcgct gtccacatcc 21421 ccgctatgcg cgattcctaa tattctggca acggtcgcct tcaccgtagt gagaacaatc 21481 tccccttgct cagtgacagc actttgcttc agcatacttc gaagatcttc tttcttgttc 21541 ttgaggtctt ttggcgggac tttgcgtcct ttctggcctt ggagcaggct caaaagagtc 21601 gatctttcgt ccagatcatt ggagaggaac ctatgtaatc gacctggatc aagtacagcc 21661 accgccgcaa gtgggcgacc gctgcgtata gcgttctcgg taagctgcag gctttcgtcc 21721 gactggatca tattgaaacc catgcgttgc cagcgtgcga gacctaattt actgagtttt 21781 tctgccatac caccgcctgc ccaagggccg taagctactg aggttcctgg aagtctttga 21841 gaccggcgga agtacgctag cgcatcaagg aatgtgttgg ccgcggcgta agaagactgt 21901 ccgggatttc caatgatacc tgatatggaa gagaatatca aaaacatgtc caaatctagc 21961 ccttgagtag attggtgcag attccaggcg ccatgaactt tgggcccaag gactcgattg 22021 atacgttccg gagtcaagtc ttggagggct ccatcgtcca acagaccggc cgtatgaacc 22081 actccacgta atggtcgcag tgcagtgaac aaggagatgg cattatccac actttcacga 22141 gaagcgatgt cgcaagacaa taccgtggcc tgagcaccag catcggcaag ctctttgacg 22201 aagctgtctg ttcccggtgt gtccgttccc cgacgggata gcaacactat atctcgtata 22261 ttgtgggaga tggcaagcca catggcgaca cggcgaccaa gacttccaag acctccagtg 22321 ataatgaccg ctccatctgt gcggagcagt tgcgctcccc tggaagtgat attcacgttt 22381 tctaatcttg gtagcaagat cccgctgtgt cgtacagcgc attcaggctc gttgatcatg 22441 gctagtgctt tcaccaggct ggtatcagcc gccaagttga tgtctagatc taccaagcgg 22501 agactcagct cggtgtgttc gttccgtgca gttcgcatta gtccccagag agttgacgaa 22561 tgcaaacccg gaagctctat ttcacctgaa cctgtatcaa ccgcgttgag agtgacccat 22621 agtagaggct gtgctagctg cgctctgatg atcgcctgca actgagcgaa agcctctgtg 22681 gtgagttgtt ccacgtgatc aacgtcattt tcgacctgag gctcccatac gcatagaagc 22741 ccagataggt cggtccatgt gttgatatcc tgaaggtcaa cccagcgaac cgataggcca 22801 ttttgtagaa gaccatccat gatcttcatc gacagtgggc cgctgtagtt cgatcggatc 22861 atcccccaag tacctgtcaa ttttgacggg tctgcagtta tagttccctt gctactggac 22921 tccttccatg taattgcgag ctcggtcgca cgtggctcaa tgctcgcgtc tggagggtcg 22981 ttcatgtctt gcgccttgat ggcgttcatg cttagacctt gatgtccatc tggtggtgat 23041 agagtgttct tgcgtaaagg tggatatcgc tccttatgga aggcatacgt tggtaattct 23101 acacgctggc aaccttttat ggagccaaag tatccagtcc agtcaatgga tatgtctttc 23161 ttatgcaact cggtcagact acgttgtata gttgtggctt catccttgcc gtgtattatt 23221 gatggtaacc aggtgatggt ctgctcattc tcaaggcatg ctgcgcccat gccggctaag 23281 atcggtcgag gtcccagttc aacaaaactt gtcgtatcct gcaagaataa cgtctggacc 23341 gcatcagtga agcgaacagc ttggcggatt tgttggaccc agtagtcggg tgtctccatc 23401 tcgcctggct cgcaaagcct ccctgttaga gtgctgacaa tgggcaactg tggtctcttg 23461 aattccacat tctcagccac cgatcggaaa gcggtcagta ttgtatccat gtggtgcgaa 23521 tggaaggcct tcgatacgtc aagcagcttg gtcttccgtt cgtagccagc aaaatacgaa 23581 gcaatccgct cgacagcact aatatctcct gaagctaccg tttgcatcgg cgtatttcgt 23641 ccagcgatgt caatctgtcc attcaattcc agtgcatcga ttgccttctc cacctcctcc 23701 cagctggcct gaagagagac cattgctcct tgcatgggca cagcttgcat caagcggcca 23761 cgagcttcca ctaaaataca tgcgtcagtc aggctcagta ctccagcgac gtgtgctgca 23821 actagctcgc caaccgagtg gccacaaagt acgtctggaa ctacacccca gcttttccat 23881 aaggaccaca aggccactcc gagcgaaaac aatgctggtt gcgcatagtc agtacgctgc 23941 agcaaggatg ccgcttcact tccgcttgga gcgtgcataa cctcgagcaa cggcacatca 24001 agtccagaaa atcgagccac aatttcatcg agcgccactc ggaaaatggg gtaggcttcg 24061 tagaggccct tgcccatacc acaagcttga cttccttgac cggtgaagag cattgcaagg 24121 cgtgaggtcg aggttgctgg tatggatgcg gacgaagttt gtgctattga gtcaagtcca 24181 ctgatcagcg tggtccgatt tttagcccag actatatcgc gtctcccaaa cagcgtacgt 24241 gtagtagcga gggagaaagc aatgtctctc aagcggaaat tgggaccctg cccatgggca 24301 gagatatgtt gtttgagttt ttcagcctgt tgggccagcg atacttcagt atgtcctgat 24361 aggagaaaag gcattgctac gcttcgtctc gattccaatg actggtaatg tggcagctcc 24421 gtagcttcca catcactgtc tccatcatct tgatccaact gatgatcagg tatctgtcgt 24481 ggaggctcct ccaccacaac atgggcattg gtccctgata ttccaaaagc tgacactcct 24541 gctcgccggg cccgcttaag tcgaggatgc cagggctgtg cctcctgcac cagcgccatg 24601 cgggagccct cccagtcgac tgcttgagtg ggctttgtag cgtgtaaggt ttgagggatc 24661 ttattgttct tcatggccat aacgactttt attacaccag ccagaccagc tgcagcttgc 24721 gtatgaccaa acgagctttt acaactgccg acccagagcg gttcgtcgtc tactgatcga 24781 ctgccgccat agacacctgc cagagctacc ccttcaattg gatcgccgag tcgggtgccc 24841 gtcccatggg cttcgaccaa gtcaatatcg cctggtgata gccgtgacgc ctgtaaggct 24901 gtctgaataa gccgttgctg cgctttgcca cttggaactg tcaggccagg ggcacttcta 24961 ccgccatgat tgacagctgt tcctcgtatg actgcatgaa tatgatcctt atcacgcata 25021 gcatcgctga gtcttttcaa aacgacaact gtacaccctt cagaccagcc agtacccgag 25081 ttatcgttcg cgaatgcgcg gcacctgccg tctattgaca taccattaag tcggctgaac 25141 tcgacatgca tggctggact gagaagtaga cttatgccgc ctgatatcgc taagtcacat 25201 tctccttgtc gtagagcatt gcatgctaga tgcgttgtga caagcgacga agagcacgca 25261 gtatcaatag tcatgtttgg accttcgaga ccaaatgcgt acgaaactcg gccggaaagt 25321 gtactacccg cagtaccagt aatggcgtat ccatcgagct ctcctaagct tggcactgag 25381 gagttgtggg cggagatggt gcacactccc atatatacac ccgtgttact gccacgtagt 25441 tgacctgccg tatagcctgc acgctctagc ccttcccaac acgtctcgag gccaatgcgt 25501 tgagtaggat ctaaggatcg ggcctcacgc ggtgagatcc caaaaaaggg ggcgtcgaat 25561 tcgtctacgg aatcgagaaa cccgcctcgg cgacagtacg ataatccagc gctatatagt 25621 tcctcggcgt cccatcgatc cttcggaacg cttgtgatga cgtcagcgcc tcgctcaagg 25681 agatcccaga actcctgagg gctggtcact cctcccggga gctggcaagc catagaaact 25741 atggctatac tttcgtcggc tgttatgtga ttcgtcgaca gtccgcgatc tggctcaact 25801 actgaagtgc cgtgcagaaa ttccacaagc gctttgatag tgaagtgctc gaatagaatc 25861 gcgggagaca atattcgatc gagtagctgc tccagtgcct tctgaacctt gattacccga 25921 atgctatctc ctccgatttc gaagaaattc gcttccgtcg ttatgcgatc atggccgagg 25981 acttctgacc agatgagccg aatactactt tccaaccccg tctgtggttg ctgactcatt 26041 gcttgcggct taacaacttc ggtgtgtact gggagagctt tgcgatcgat ctttttgttc 26101 ggggtcatcg ggaattcctt cagttctaga tagaacgccg gcatcatgta ttctggcagt 26161 cgcgatttta ggaaaggtcg taagaaagtc tcaatgctcc gtgagtcttc gcacccgttc 26221 ttcgtttgtg ttttctgttt gcgaatacag taagccacga gtctcccctg ttgagcattc 26281 actacagctt ctgcaatgtc gtcatgatcg gtgatggcgg cttcgatatc tccaacctcg 26341 atcctgaaac cgcgaatctt gacttgacca tcggcacgcc ccaaaacgcg tagggaatcc 26401 aatgagtcga aacgtgctag gtctcctgta cgatacatca agcccgggtg gaacggatta 26461 tgtatgaacc gctcttgggt tatctcaggc tttttgtggt atcctctagc cagactagcg 26521 ccaccaatga acaattcgcc ctcggtacca ataggaaccc tagagaggtc attgttatcc 26581 aacacataaa gtcgataatt attgattggc cttccgatca ctacaggctg gtctggacac 26641 actcgccaca tgctggccca gacagtcgct tccgtagggc cgtaaacgtt ccatacagat 26701 tccgcgcacg agagcaatcg atttgcaagt ttttgaggca gtgcttcacc accacatatg 26761 atcgtggaaa gatggacatc gctatgccag ccagactcga ggatcatttg ccaagtagca 26821 ggcgtggcct gcattattgt aatactatgg cgcttgatca tactcattag cgcgcgtgga 26881 tccctcgttt ctgccttctg ggcaacaacc acagtcgcac cgcagatcaa cgggagaaag 26941 atttctagca tggcgatatc aaaagagatt gttgttacgg cgaggagtcg gtccgatgct 27001 cgacatccag gtccggacgt gctctttatc ccgagcaaca agttgcacaa tgcctcgtga 27061 ctgatctcga ccccttttgg ttttccggtc gaacctgacg tgtatatcac atacgcgaga 27121 tcatcagggt ccacatgact gtctgaagca gtagtagaat gcggaagctt cttttcaaca 27181 gtgtcgatat tcagggcagg tccgcgccag aaagacattg agctctctgt agatgcttca 27241 acgaccacga gttttgggtc tgcatcttcc agcatatgat gaatacgatc ctggggaaaa 27301 gttggatcga tggggacata tgcggcacca gctttcaaaa cagccagcag tacgacgaca 27361 agcataagag accgatcgag cacgatgccg acaagatcgc cacgcttgac actatgttgt 27421 tctagtatgc tagcatatcg gtccacgaga gccccgagct ccgcataaga taatttttgg 27481 tcgccacaaa ttgcggcgac attctctgaa ttcgtcttaa ttacctggtc tatcagatga 27541 tgaaggcaaa gccccagtgt ggttgcatca tctgtagcat tgaactcgtc tcctacgccc 27601 tcctgagctc tactagagca tgtatccgac attgagggta ggtcaaaact ttgtcatctg 27661 gagttgatgt gctatgaatg ttgaatatca gcacgaacca gcgtgatcag caccacttac 27721 aatagattac gctccaatta tgcggcaaat tttcgtatcc atcgatgccg ttcaaaatat 27781 aggagttacg agatcagcct gaggggcgtt ttaaaaaaaa actatagagt cagacgagta 27841 tcatgggggt atatgctaat atatggtgag taagacattc cgagaataag gttcaaggat 27901 atcggaggtc tgattttcca tttgtgtgct ttctttcggt tgtttagttc ctaaatctgg 27961 cattctgcga gcacgataac ggggcatatc tcggagtccg tcatcttgat ggggactctt 28021 ttctatttac tagtacgcaa acgatataga gtattatgct ggtcatagtg gaccaattcg 28081 ccctagtcat gccggctggt aagtattcga gtctggcgtt cttgtgacaa tcagttttca 28141 tttgatcacc aataggacgt gatacggtcc ccaagtaggt agtttagtgg cgtagaatct 28201 aacagcgcag ctttttcttt tctaagaatg acctcttctc aatgtataaa ttttctctta 28261 gcaagatctg cactgccagc tccactactt tcgatcgtcg ccaattataa tacatggcac 28321 gctgccacgt ggttgtgatg ccatattcgg aacccgactg ccataaaaaa caattccgag 28381 tcggaatttt gtctcatttt tacgaagttg gaaacccgat cctccacagg ccatcatcta 28441 tcaagcgccc ttctaaggtt ctgcaaccgc aaactaatat aactacgctt gtccccacac 28501 atggccatcc agttcgtgaa acactaccaa gccctattac gcttgctcat aaaaatctca 28561 caatggcacc cggaatcaca cttgacaacg cagtggaaga ctttgtcttc accaagacag 28621 ctggttccga gaagaaccat gcaactgtta cagaaacagt tcttgaggcc attgacaatg 28681 aaaaagcagc ccagccaaaa caggcaccac aacctgagcc ccaaaatcag ctagacctct 28741 cctctatcgc gtgggctcac tgtcgcgaga gctccaacaa tttcatatcc gatttttaca 28801 ccaaaccgac ccttcctatg ctagaagcca ttatccgtac gacactcgac gacggtgaca 28861 atgacgaaga cgctacaaca aacgacttgc aagactatgt tgcaggcctt ttaggacacg 28921 agagtgcttt gttagtcccg actggtacta tcacaattct taccatgttc gatcacgtgc 28981 ttacgaccct ctaggtacga tgggtaacca agtatcctta cggactgccc taggcaatcc 29041 accgcactcg attctgtgtg actatcgcgg ccacataatg cacttcgagg gcggtggacc 29101 gtctggaatc tgcggcacgc tcgtccgaag cgtagtacct gcgaatgagc accatctcac 29161 gcttgcagat gttcagagat ttgccacgct acggaatacc atgtacgact gtcctacgcg 29221 cgtaattgca cttgagaatc ccatggaagg acgcattctg ccgctgagcg acatccaggc 29281 catctcgaac tgggcacggg aacggggaat ccatatgcat ctggacgggg cccggctatg 29341 ggaggctgtt gcagcaggtg ccggatcact cgaagaaatc ggcaagtgtt ttgatagtat 29401 ccaggtgtgc tttaccaagg gtcttggcgc accactcggc agtatggtca ttggaaagaa 29461 agacttcatt gctagagcca aatggagccg aaaactactc ggtggtggga ccagggcatc 29521 gggtgttatt gcagcgccgg cacgagtcgc gattgatgat gttctatttg gcggcaagat 29581 gaaggctgcc caggacaaag cgcaacgggc atccgaatta tggaccgaac ttgggggtaa 29641 gcttttggag cgcagggaga caaatatggt atggctggac tacgaaggat caggggtaga 29701 catggaaggt ttctttaagt tagcaaagga ggaatatggg ctgaagttgg gtggtgtgat 29761 cccagagaga ctggtctttc attatcagat ctcggacgag tcgtttgaaa agttgtgtgc 29821 actgttccgg agggctttgg caaaatgaag ggcttcgtac agggggcagt gagtgattgg 29881 atacttaaag attagtccaa gtacaacagg cttgcgtaat tctgctaaac atttgtgatc 29941 acgccttgtg gggttacacc aagagccgtg tgtaagcgaa tgactgtctg cacaaacacg 30001 gcacatgcac atccatgcca ccgtgttgac tttttttatt gatactgcat gctcggcgaa 30061 aagaccgaaa attaaaactg ccgtctgacg ggttgttgag tttcgtcagc gagtctataa 30121 caggggcttg taaatgtccg taatcactct tttgagaagg ggcacacact aaatgattac 30181 ttcgccacgc ctgatatgtc tgatgatgtg agtttgagtt ttcaattttt gtttcccgca 30241 gctataaatc tcgtggtgat tttttgccta tacagtagtt ggttccactg gcgctattga 30301 tgacttgcgt taggcacccg ctatgtatgg cggcatatag gccgggagtg gggtgacgac 30361 ggcgtggctt tcttagggcg tcccgcggta cgcgttgggc ttctctaagc tagtactagc 30421 atgagcatcc ggacccactt ccgagtctgt ttactcccag ccgttcgggt catggtccga 30481 gtcttgagcc cgctagtccg tatgcaaatg ttttgctttc cgacttctcc gaatcacttg 30541 gtccactttt ggctcgtcta tttctcgtac tccttgtcag ccaatctgct ttgtcgagat 30601 gttgggggct tcacccgcac gcagctgctt tattacctgt tgaccgccct ttcttttgct 30661 tttccttagg atctgcattg catctgcatt gcattgcatt tgctttctgt agcgcctaca 30721 ctcatctaat acgcacgccg caaaaacgcc actctcacaa tggtgtaccg acctagcgag 30781 gataaatccc acagctcaat atacctgcat gatgtacgta ttgcctcaag cacgtcgacg 30841 aacaatgctt cgaaggcatc ccagtctact attgtggatg ctgagcatca gttcggggag 30901 agcgagagtg taccgaacaa tggcatcgag ggcttcgatt actccacttt accacctgtt 30961 gataccggaa aagatgcttg gttgtgcctc ctcgcggtct tcaccattga ggtcatgata 31021 ttaggtaagt tgatcctgtg tgatatcccg tcttttatgt gcgcagcacc gaacttgaca 31081 ttgcatgcag gctatggctt ctcgtatggt gttttccagg acttctacgc cgtaaatgag 31141 ccttttgcat catcctcatc caatagttct gtgattggtg tcctcacgac cgtaggcatt 31201 cttgcccagc atatctcaaa cttgcagcta aatttgtgaa agggcattct cttcctcact 31261 accccgatat tccttccatt atgccgccac tatccccaat gggcccgctg gatggcgacg 31321 ttcggtgtct ttctcgcgct aatatcgaac attgcatcct ctttctgtac caaaattccc 31381 caactgattg gtacacaagg tgtgatactc gggctcgctg gcggcctggc attctgtcca 31441 tgcctggtct atattgacca atggttcgac aaacgcaaag gcctcgcatt tggcatattc 31501 ggctctggcg ctggattcgg aggagtcttt attcccctca tgctacgtgc catgctcaat 31561 aacgtgggct tcgctaccac gatgcgcatc tgggcgggaa ttcatgcagg tatcggactc 31621 actgcagcct atttcgtcaa gccacgtcta cccccggcgg caactctcac aagaccattt 31681 tggaacccgc gtgctctgcg ctcccggttc tttctgatga accaactagc aaacacgatc 31741 cagggcgcgg gatactatct cccaggaatc tatctaccaa cctatgctcg cgagattctt 31801 ggtgcatcag cctggccagc cacggtatca ctcatgatat tcaacataag tgcaactatc 31861 ggcctcatac ttatgggcca cttcactgac cgtttcactt cgcgcacctg tatcttggta 31921 tcctcgcttg gcagcacgat tgcggccttg atagtatggg gtcttaccac tcatatagca 31981 acactatata cattcagcat cctctttggt ctattttcag gcagctggcc cgccgtatgg 32041 cctgcagtca tgcgagagac ggcccgtcgg ggcgaggagc gtggttttgg gtatgttgac 32101 acactaatgg tgtattcatt attgtgtgtc gggcgaggag ttggcaatat cgtttctgga 32161 ccactaagcg aagctctcac aaaggacatg ccgtggaaag gggcagtcat tggcgggtat 32221 ggaagtggct atggagcact gattttgttc tctgggctga cgagcttggt gagcggtatt 32281 aacaccttat ggtatcaaaa gctatagttg aagttttaaa agtattttgc tgatttatag 32341 aatacaaacg atagacatga tagacagttt tatatagagg atcaatatac ttatcaggct 32401 gctgtacata gctcatacaa agatatacaa caacactgct gctgttgata ctcgccccca 32461 ctgtcagaca agacagatct agatgcaatc ctacgagatc cagtagcccc tgagaagggc 32521 cgactcaatc catcgtatct agcaagttta acgagcggcc ctggagtacc gcattggcca 32581 acgccaagtc ttacgaattg cgggacttgc cgttattatc ataagcccta aacaaagcca 32641 gactattaga ataattaccc gtagtcgcat gagtcaaaat cccagtcact gcgtttgaaa 32701 tagctttgcc attcactgcc gtgttcgagg aggtagcatc cgacgttgcc ttgaaaaagg 32761 caggggtttc ttcccgggca agtagaggta ggcaataata cagtcatcag ctgtgaaccc 32821 gctaatcact taacttccaa tgatccaacc ggtaatcatt ggtacaatgt gacacaatta 32881 ttcatccgtc acacaatgat tgttcactta tacaatcgtt agtcatttat ggaatcagta 32941 atcaattact caattagtaa tgagccatca ctacttagca gagcctcgtc tagtaatatt 33001 cgtgctccac tactcaatgg aacaatgact ttctgacatt ttcatgtcga atatttatat 33061 agatgtcaat ctcataatat aattgtagcg tgtaaatcgt cgagtgctca tataagatgt 33121 ttagtctagt tctagtacta tcctaatagc agtcacggta gtatatctag atagaggtta 33181 tttgtgaatc taatagccgc ccaggccgtc atgtctgccg gtaagcctag acttacaatc 33241 gggaggtgcg tcagcgttgg aattaagcat gttcgttcag gcgaactcgc tgactatggg 33301 ggtcaatctc gagctgagtg ttaagaaagt acaatgaaag ataacaatct actgtcactt 33361 tagtagaatg atcatgcaat gatgagtgcg agaggatatg cggtcataca cgtcttagaa 33421 ttctcttaca aggactttgt acctggagtc ttgacgtagg cggaagacat gtgtagctct 33481 gattcgaaag tctaggggtt gacttgctgg caattcctac atcgtgaccc ccaaggaggc 33541 ctaccccata tgaatctaat agtactaagc ttacaacgga agtgctcgat attgacgatt 33601 tcaccgtcca tatctctatc atcaggagct cataatatca ggacgatatc attatttgcc 33661 tagtctacct actgtgagta gagtttactc ctgaaacgga tgctatcata gacaactgaa 33721 cttgctgaaa gcacaacccc tataacaatg tacacccctt tcggcagagt ctgtaccaaa 33781 cctccaagtt ttgaacattt cgtagacttc tctactggtg tgaaaacaca gaatatgctg 33841 ttcgagacat actttataga gctctacgtg ctgcttacat actattgtta gatatacgat 33901 gatacaaaac cctgtatgcc cctagtgtgt cagtaacatt aggataagag gaccatgtag 33961 cacgtgatat gttgtcatca atgttgattc tggatttctc tatgattatc agctatttaa 34021 tgagtgttct aagcatttag tcaagaatgc agagtatgtc aggctaagtc tacacgtata 34081 gccatgttcc ttcgatttcc tatttttcga aaagcttgtt ttcttccttt acattcgagt 34141 ttcttaagtc aattaaaata cttattagct attctattct cttattggga agaataggta 34201 gctttcaaag atcgtgtata caatactagc atatagttat tccaagtcta aatattttga 34261 atttagcaac ctacctagga tataatcttt tagtcccaat aggaataggc atgatactag 34321 atcgaacgtt tatttcgatt tatttagact tgaaaattgc tatatctagt attccgtgca 34381 cagctcttaa atgctactta gtttcctaac aagagcatat ctactaagtg actaggctgt 34441 ttgaaagtca ctagttgttt aagatttaat agcaaggata taggaacgga cacatcttat 34501 tgtcgactta gtctgtctgt catgcaacat tactagtgct atattacctc cctatgtgtc 34561 tccatcgtcc taccaggggt agtacttgtc cactacttgg ccttctctcc ttgctggtag 34621 cggtcgtcta tgatacgaaa ctcctaatag agatcttctc tcaagatcag acgcattatt 34681 atcacataca ttcctgctct cttatctcct aggcgtaaat taatcattta tcttaaacac 34741 cacccattgc acatctctct acaccttgaa cgtagtcaca atctccgcaa taaaatactc 34801 gcagaataca gcattacaat ccatagcccc tgttcccgct tccggcatca ataccagtcc 34861 acaccaaaat ctaattttct gcctattatc ttcgtatact cgcacattac tacttatgta 34921 gcttttaata aatccaccct ccgccttgca ccgcccgtag ctaacttcat acaataagcc 34981 acgcgcatgc ttagtcgatc tcaaaccgaa atcgcaccat attccagctt caatccccga 35041 acgataccca tctgctagag ggagtaatac ctacctacta gtacctagca acccctagtg 35101 acttctcgtg agacctttgg gcagtcctac gctaatacag tgcactaata tagggtaacg 35161 agacggatct tcgagagata gatatataaa atcctaggag atagcagcta cgtaggagga 35221 gagggggccg gagagtgctc tggagtatgg atttatgacg ttccggttta gtccattggc 35281 tagagcagca gcagcagcag tagcagcaat agcaccacct ctgctccctt ccatccctag 35341 tctatctact atagcctgcg agtcgcttgt attgtggggt aagctcctta cgttaatgtt 35401 gcatatcacc cgaccgaacc gctccttacc acgtccatgt tccacactac actgcaccgc 35461 atacgcttac ttgactatcc atctccgtac ctatgtctct atctacctcc ctagcaatct 35521 ccctagcccc tccctatccg tctcccgatc catctctcta tctatctccc tattgtaatc 35581 catgttaaca cccctatcaa caaccatacc acacaacacc acacaacacc acacaacacc 35641 acacaacacc acacaacacc acacaacacc acacaacacc acacaacacc acacaacacc 35701 acacaacann nnnnnnnnca acaccacaca acaccacaca acaccacaca acaccacaca 35761 acaccacaca acaccacaca acaccacaca acaccacaca acaccacaca acatcaacct 35821 cccaacgaac ctcccaatcc caacgcacat tcccatccct gttcaacctc tccatcgaca 35881 cgcacatcaa cattaccatc aaatctccac atcaacctcc cctagtcaac acccacacca 35941 acaaccttca caccttccaa tctgaaaaca gccaaagtag cgtattatac agtccagaca 36001 aaccagcaat tcaccatagc ataccgcact accactacca cactactata cactactacc 36061 attctgaata tctctctcta ttagcacatc ttccatttcc ttccattttt agcttagaac 36121 cccgtctacc ataaccccta ccaaccccaa acagcatacc cccaaccggt atcaatccca 36181 aacacattat tactaacaaa cccccctccc cctttctccc ctcataaacc tctcctaaac 36241 cccctccaaa ccccctccta aacaattcca taaaccataa accacaagca agatagatat 36301 acaaagagca tacaacaaaa caaacagatc taaaagaccg acaaagaccc acttggctaa 36361 acgattggaa gtcggtatat acatgttatt ctactatcat tactaccatc attattatta 36421 ctaccatatt tctttatgac tataactata actataacta caactacaac tatacctaca 36481 actctaatta ctagtattat tagcattatc agcagtctag acaaggtgtt tttcttcttt 36541 tctttttgga caaggggggg agggcggaca gttcggtgtt tagtaagaat ttggccaaaa 36601 ggtaaaaaaa aaacagaggg gggggggggg gggggctata agacggggtt tgggtaagtg 36661 gtagaatgga ttttttgtgt gaggttcgaa tggagcagta tatcgaggag atagatgggt 36721 tggatcgggt gactcgactg gatggatata taggtctaag agtaagaagt tggtataatc 36781 atttcaagta atcgagcaag cggacttttg taatgctgta tcataatctg aaccccccta 36841 tcccacgcca cgccacccac cacccaccct ccccctaaaa agaaaaaccc cctaccccaa 36901 actctgcacc ttcaacacaa acgccccccg ctcaatcgta ttaacaacaa taaaccccga 36961 ctcaaacaac gcatacgacg accacgtccc cacaaaatca ataaccccgc cattcggctc 37021 cgcatcatcc tccgggtaaa catcaaaaaa cgccacctcc ttcacccccg ccccggtcgg 37081 atccgcgggg atagacgaga catccaagat ccggaaccca gagccataat tactctgata 37141 cgcatacttg cccgcgatat actggttatg atcgaccgag taggcggtgc tcttgtagta 37201 gcccgtctgc ctgggtcgtt ccagctcgga gatatcccag atataggtga caggatggcc 37261 gtcggccgca gggccaacgc ggtcaaactc gtcgtattcg tcgtccatga tcaggtattc 37321 ctgccagtcc gggtcgagca cccagccctg gtgggtgtag gcggcgccgt cgtaggaggt 37381 gacggagacg aggtgcgggt cgagcttgtc ggacatgtcg tagatggaga gcgagtcttc 37441 gttgtagccg tagcagatct cgcggccggc gtacttggcg tcgggcccct tgtacatgag 37501 gcactgggcg tcgtggacgt agccgtcgat ggcggcgcag ccgggggagg tcgggtgagc 37561 ggggtcggac atgtcgattg cgatgaggcc ggagcggcat ttatctgtgc ggggggcggc 37621 gccgacggag tatgcgaagc ccgaggccgg gtttgcgacg acgttgtggg tgcggccgat 37681 ggggaggtcg gtgaagatgc cggtgacgtc ggtgtcgggg ttgaaggtga cggggttgcg 37741 gttgtcgagg tcgagcagct tggtcatgtc gaagatctgg atgttgtgct tttcggcctc 37801 ggagccgatg atcatgtagt tgttgtagcc gcggatttcg cgccagatct cgggctcggc 37861 ggcgctggtc ttgggcaggc ggccgaggta ttcgagcttg ccggctgtgg tgacttgggc 37921 gaaggctgcg ccgtcggctt gggcgatggc gatgaactct cggccgtcgt cggatgtcca 37981 gccccatgag gaggatccct cgccggttgc gctgcctaga gcggcgtggg agaggaagtg 38041 atggaggttg agctgggacg ttgttagtgc tgtctgtgat ggacatggag agggtgcttc 38101 gacatacgtt gttgcagcga aaggccagtg tagcattgtt cctgaacggc tgggcttttc 38161 catcccgaca attggcaaaa gggagctcga tgtattgctc cgagttcatg gcgccgctgt 38221 cacgctgacg ctggaatgtg cctcgcttgg tggccatgat ttccatgtgc atagtcccgc 38281 tgtcgtactt atcggctgca atgctaaagt cctttggctt ctccttgcac aacacactgc 38341 ctgccagggc ggcaaaggta gcgagacgat acatgatgag agtcacacaa acgaaagtcc 38401 actcgttgtc gtgtgagaga gtccagagga ggtccagggc agagatgatc gatcaagtag 38461 ttctacccag aggaaggctg gaaggagctg gtcaatcggt cccagagcat ctccttttgt 38521 aggcccccag gccgcagtat atggcaagac atgctgtcct tccttatcga catctttgta 38581 tacatggcat atcactgctc caaggagaag gtcacatacg acctaggtcg acccgatgat 38641 tgatgaaagg acgttactgg tccagggatc aagcattccg ccttgcccca gtctgccgag 38701 aaggctgatc tggagccaag acgagcagcg tgcttggcgt actccgcccg tttgtggatg 38761 gatgcagccg agcaccatcg atcagccact cgctttataa acacatacct attatgaatg 38821 taacgattct tcctgctgtc tatcagtctc tcatcgcctg ctgcccctct ctaattctga 38881 tgctctcaca cagcagatgt agccgtgtat caatcgaccc actggacatg ttgtttacct 38941 gacaagacag gagtcccctg tcatgggcat ctatctccgc gccaagtgta ctagtcggta 39001 gatggtatat gaatggatcg caagcatcga gtaggctacc ctgggcagat cgacatatca 39061 ggtaggtagt acgcaaacgg agccggagct cgcgacaggg ctgtggtcag cattcctccc 39121 ttttttgcct aatatgaaac attttcgatc gacgtttact ttcaaaacaa ttcgattgtt 39181 ggaattgttc aatgggagat aattcggaaa atatatcctc cctatcagtc actgcgcacg 39241 acaaccggct cgaacaagtg aattacacgc cagaatcttt attcttacta cccggtatca 39301 tacgtgcata acgttgatca tgaatgtgcc acccggagag tcctagtcct gtatggacaa 39361 acgcatgatg cccctcatca cgctcctata atgaaaactt gcctacgacg ccgttgctta 39421 tgcatgaccg caaaaaggga aatcataaca gtcatggctt ggagcctctt atgctgctcc 39481 gaaaacactt ctcacacggc ggagaatttc cgcacccata gctctccgtg tacccaccgt 39541 tcgagatgcc gcatccttgt tctctgctgc tcttctgagg agatagttca aacactcccg 39601 cgtcgtaccc caggacacac acttgtatgc gaacggcgta tcgacatctg caggccgtga 39661 tacacccctc gtcttgtcca gtaggttgca gctgacctca tctgccatgc ccagaagttg 39721 tgcgtatgca agcttgatcc gtggctcgcc atttgcagcc tgcgcatcgc gaatcgcgcg 39781 cgctttgcgt acagactctg cattatgcgt tgcgataacc agctcgacct ctggaaatgt 39841 ggtattttct ggatctgcgg gacggagcat gtcaccgtac tgccgcttga gcagggattc 39901 agtcagttcg tcgtagcatt tgtgcgtctc ctcaatggtg gcccagagaa gatgtcgcgg 39961 ttcggaattc agatatgcgc ctctgacgag cttcacacca aggatatagt tatgcttctg 40021 tgcttcggcc aggtcacgtg caagattcac gggtgtgctg cggtcgtagg cttgataggt 40081 ggtgtatact atggcacggc ctcgttcctt ggtgttgtat ttgcgctgca gagcgcggtt 40141 ccacgagtca atgccgatat ttgtggcgtg ttcctctgcg tcattgagaa gcatcacgcc 40201 tttcgcagag gctcggtcac agagctgcgt gattgcgtcg tgcataagcg gcgtgggtgg 40261 cttattctgt tttagaagct gtagggcata tgggcccagg cctgaccatc tattggcgag 40321 atcagtatac gctcacgaac tggcatgtat ggttttgact cacttgatgc cgacaaaatc 40381 gccgggcgcg caaatctcga ccgtttgtaa agcacccttt ctccaatgct caacggccgc 40441 cttggtctcg gcactatcag cactcaaaga cgactggcct ttctcaccaa ggacttccag 40501 agcatattcg agaataacgc ccttgtagcc caggtccttt attcgagcca tagtgctttg 40561 tatctctgcc ctattttctc ccgcacagaa ttgagcatag aatgtcttct tcagcagcca 40621 cgagagaatg ggattcttgt ccacattgag taaagccgac tttgactgta gcatgcgcgt 40681 caggagagcg agacatgcgt ctagcagtat gggcgacgag gacatggctg tgatgacata 40741 gcttcgtagg acatcggagg cagggagtcg ggatagggga ctggtaattg gaggtttgga 40801 tacggcatgg tgaggaggga ttgaaggaaa cggcgaagct ggaagggcga cactccgagg 40861 cttgctggat tggactgaac gagagaagct gaggacgtat gtcggcgtca aagtccggaa 40921 atgtctggca gcgtgcatct gagatctcat tgtggccata tgtagggaga gaacggaaaa 40981 tgagagcagg agatggagaa aagagagggg aagctggtga tgaagcggga ggggggactt 41041 gaaggtgaag ttgatataag aaaggtacga actggcaggc acggactggg gttacgcgac 41101 ttatcaggtc tcgtgcctac ttgggtactt actattaagt aacttgtctg cactgcagct 41161 gaggaggtta tctgttactc gaccgaccga tataaagcaa aagacgcgat ctattgcgaa 41221 gtggactggg aggcatcgaa cggctagcat cggcttgcat gacctgagta ccagagtcca 41281 gtaaccagta gcagtctgag aattgcctaa tcaatccatt aattagtggt atgaatgtca 41341 tgcccagagt cccaagtata aacatttccc cggcctctcc gatgacgtga gcggggagca 41401 ttctctcgtc gatggaagca gtgcaaacac gatgctacac tctatatacg ctgaacgctg 41461 ccagcactac ccatgagtat tccatcacca gaacaaagct gattgcttgt ctccctcact 41521 tcactttact tcacgtcgcg tcccatcacg gcaaaatgaa tagattcgag accgatataa 41581 gtccgtttga tctgtccaag agccgcatct aaccgatatc tgtgccccgc ccatgctccg 41641 ataccggatg gattggacga ttgataacgg agttttggca gtggaacttg gccttttatg 41701 gatcaccgat ggacaattaa cagtcagaag acagtaaaca cgtagaagta gacaaagtgt 41761 gatgatgatg atggtgatgt tgacagacga gacgagacga ggacttagta ctcactaatc 41821 aggtaggttt ccagtcgcct agcactaacc tgtatttgga gtgactcgca cgtgatctga 41881 gctagcgtgt caaccgccaa acttttctcc agtccttcac ttctgacttc tgctacgtgc 41941 caacgtcaac aacaccacca tcgccatctt cgacttctat tccaggcata tatctcgtgc 42001 atcgaccgaa gcaatgataa acctatgctg tcttgatcac ctgctcgtcg agtatatgac 42061 agtccagatg tcctggtgaa gtgtgacgct gtatcgtcac ttcatgcaca gtatcattgg 42121 acactcgcaa caaacatgcg cactatatcc tacgcacatg acagactcct catctgcagc 42181 agcatctcaa ttcagcacct ccaagcaacg caaacactca acccgccgct tcaaacccta 42241 taagctcctt cgggaatgtg cgcttgacgt cttgcgtttt gcttgaccca agccacaggc 42301 gggaaagctg agtctggact gggacgcctt atccgcgctc ctgtatccat ccctttgcaa 42361 gatcaagatt tacctacggc ccctcatagt tctcactact tgacctctcg cgggactctt 42421 ttataccgag agtgggactc cttgcgtgcc gacattctgc gggtctcttt acttcgttat 42481 cacagttccc ctcatttagg tcactgtttt gtgattgtga actttggtga atgctgggct 42541 agagcctggg gttagggtta gagttgaagt gcgtggttgc atgacggggt gtttgagaga 42601 gcattacgcg gatcggagtc atcttgagta tgttgtaggt ctgatggctt tgatatcaca 42661 taaatcctac gtcgacagca atagcaacat gcagctaaac atttcacata tccaaagatt 42721 ctgcgtactg ttgtatatgt gacgtcattg gactagactc ccactgcata catggttaag 42781 tagctgccat gccaccaaca acaacacata gccaacccac ttgcttacat ccgtatgcca 42841 atcaagcaaa ttgtatagac aagttacacg acacgcaatc tacacaatca acatccgcca 42901 gcatgggcac agagtcctcc gaccagaagc atccccagtt cggccatctc cccctggcaa 42961 catcgggacc acaggaatgc gcactcaccg gcaacgccct gctgcgcaac ccatacttca 43021 acaaaggctc cgccttcacg gccgaggaac gcgagacgtt caagctccac ggtctgctcc 43081 cgtcgaatgt gcagacgctc gaggagcagg tcgagcgcgc gtacaagcag tactgcagcc 43141 gccaggatga tctggcgaag aatacgttca tgactagcat gaaggagcag aacgaggtgc 43201 tttactaccg ggtatgtggc agtggatggc tacttttatg ggagggtgtg tgctaatatc 43261 tggtagctca tccaagatca tctcaaggag atgttcccgg tcatctacac gcccaccgag 43321 ggcgaggcga ttgccaatta ctcgcgcttg ttccgccgac cggagggctg ctttctgaac 43381 atctacgaca tggaccgtat agacgacaat ctcgcacagt ggggtgcccc tgacgatatc 43441 gatcttattg tggtatcgga cggagaacag gtgtgcagat agtcgatcat gtagccacca 43501 ccactgacac caacaaaccc agatcctcgg catcggcgac caaggcgtcg gcggaatcct 43561 catcagcatc gcaaagctcg tcatctacac cctctgcgcc ggcatccacc ccacacgcac 43621 cctccccgtc gtcctcgacg ccggcacaaa cgtatgcacc cccttcaccc cctattcccc 43681 aaacacaaac cccccttttc cacacccaaa ctcacacccc caaccagaac aaagccttcc 43741 tccaagaccc cctctacctc ggcctcccca aaccgcgcgc cccaacccaa caatacaaca 43801 ccttcatcga caccttcatc cgctccgccc gcacccacca cccaaacgcc tacatccact 43861 tcgaagactt cggcctcgca aacgcccgca caatcctaga caaatacacc ccccacatcg 43921 cctgcttcaa cgacgacatc caaggcaccg gctgcgtcac cctcgccgcc ctcaccgccg 43981 ccctgcacat cacccgcacc ccctgggccc acctacgcgt cctcgtctac ggcgccggca 44041 cagcaggcac cggcatcgca gaccagatcc gcgacgcgat agccgtggag acggggcgcg 44101 aggccagcga cgccgccgcg cagatctggt gcgtggacaa gcacgggctt ctcctccgct 44161 ccgacggcga gcggctgacc tccgcacaag caagctacgc ccgccgcgac gaggactgga 44221 cacacacacc ccacaccgac ctcctcagca tcgtccacgc cgtcaaaccg cacgtcctca 44281 tcggcacgtc cacccagccc ggcgcattca ccgaggccgt catccgcggc atgacctcgc 44341 acgtgccgcg ccccgtgatc ttcccgctca gcaaccccac acgactgcac gaggcgcagc 44401 caagcgacat tttcaaatgg acgggtggca aagcgctgat cgccaccggc agcccgttcc 44461 cacccgtcga gcacgacggc gagacgtacg aggtcgcgga gtgtaataac tcggtgtgtt 44521 tcccggggat cgggctcggg gcggtgctgt gtcggacgag gctgctttcg ccggcgttgt 44581 tggttgcggc gacgagggcg cttgcggcgc aggcgcctgc gctgagggat ccgaggaggg 44641 ggcttgtgcc tgatgttacg gaggtgaggg aggtgagtgt tagggttgcg gcggcggtga 44701 ttagggaggc gggtagggag ggactgagtc gggtgggggg gattccggag ggggaggcgg 44761 agttggaggg gtggattcgg gagcagatgt gggaggctcg gtatcggggt ttggagctgg 44821 ttgggcggga gagggcgagt agggttgcga ggggggaggc tggggcgacg gggagtcggt 44881 tggcgaggga gtagatggat ggggtgagaa agaggagtgg ttcatcggtc tacgtctata 44941 ttcgatatca tgtcacatct acatggtgtc tatacagtcg acgccctgaa cccacgcacc 45001 aagtccccct tcaaatcaac ccagtcctcg atccccacac tcacgcgcaa cagccgctcg 45061 tccacgcctt cgtcgctcat gcgccgccac tcgatcaggc tctccactcc gcccagactg 45121 gtggcatggt ggaacagcgt cagcttcgag ggcagggcgc gcgccgcgcc ggcagtcttc 45181 atgttgattg cgaagacggg gccgaagccg ccgggcattt gctgcttgag ccagtgcatg 45241 tctgctttct ggaggctggc gtgctggacg ctgtgcacgc atgaccttac gattgctgct 45301 tcttcttctt cgtcttcttt ctcccccttg ccatcctccc ctttgacccc ctgactctcc 45361 ccccttaaac acccatccaa ccaccccacc agcctctccg cactctcact ctgcctccgc 45421 acccgcaact ccagcgtcct cacccccctg atcccaagcc aagcctccat actccccggc 45481 acagccccca ggaaaaccct ctccacaccc aacccctcaa cccactccct ccgcctcacc 45541 gccagcaccc caagcaacaa atcgctgtgc cccccaatat acttcgtccc agaatgcatc 45601 accacatcaa ctccatacgc cccaaacggc tcctgcaatc ccggcgggcc gagcgtcgcg 45661 tcgacggaca cccatgcccc gcgctccctc gccctcttca caaagaacgc taaatcgcgt 45721 gcttcgccgg tgggattaac gggtgtttcg acgtgcacca agtccccctt ccccaagccc 45781 gctgcatccc aggcttcgtc gtcagcgaag aggtctacaa ccttgcagcc ggtgagtttg 45841 cggtatatgc ccagcacgcc gtggcagccg tggtagccgc cggagatggc gacggttttg 45901 gggtggaggt agacgagcaa ggcgtggaag gcggcgaggc cggaggtgta ggcgaggacc 45961 ggggcgtgca ggagggcgga gaggattgtt tcgaggcggg ttgaggttgg ggcggagacg 46021 cgggagtaga tgtgggttgg gtttgcgagg gtagggttct gtggttgtgg gttaggagtg 46081 gttgaacgga gaggggagga ggatgatggt acctcgtcgc cgttgatcgg gaccaggtcg 46141 tctgggttct ccgggtagcg gaaggtcgtg gagacgtgga gggctggggc gacgtctgtt 46201 gttgagttga ggatgtcgtc ggcgtggagg gcgagggtgg acagggcgtg ggttgtgctg 46261 ttcaggctgg cagtggtttc ttcttcgaca tggggatcca tgatgatggt gttggttgga 46321 caattactgt agtaaggtac gatgcgatga tggatgtttc taaccaagtg gcagccagct 46381 gcgtagtgag taggttcaat gtactattca caccatccaa cactacctac tgtctgccgt 46441 catgctagcg tggacgtggg tgaaatgcct gttcattagc gcggggtagt ggggtaagcg 46501 tgcctacggt ttccctagtt gagcgacggc gacgtccatt gatgcaggct aatcaccata 46561 aacaaagacg aaaagaaggc atgcagcaca tatacaggcg cggacagttt ggcagtattc 46621 aattggacgg tttcattgtc tgagagctgc tgctacaggt gtgcggttgc tggtttgtac 46681 cgagatgcta cagctcgtaa acagctcgct agtattgtat ctttagggac aagattcttt 46741 gggccgtcct ttatagtatt ccggacttgt cgatggtagg ggccttgggg tatttgacag 46801 cgccagagtc gcttcccgcg gcctcgatac cccggacaac cttgtatgaa gcaacgtcac 46861 cgtcagggac ttctccgaag acgacgtgct tgccatccaa ccagctcgtt acgacagtgg 46921 tgatgaagaa ttgagaaccg ttgctacgac acaccttaat gtcagctcac tctatcggga 46981 gtgtgataca tggcacgtac gtgttgggcc cagcgttggc catggacaga aggaatggct 47041 tttggtgctt tagcttgaag ttctcatcgg cgaacttttc accgtagatg gactttccgc 47101 cagtgcccta cgccaatgtc agtagttgta tctttggctg cacggtgttg agaagtcgca 47161 tacgttaccg cgagtgaagt caccgccctg gagcatgaac ttggggatga cacggtggaa 47221 cttggagcca gcatagccaa agcccttctc gtttgtgcat agggcgcgga aattctcggc 47281 agtctttggt gtaacatcgt cgaagaggtc gaagttgatg cgtccgcgtt gctctgaagg 47341 gattgatgat tagcactcga gcatcaacga agcgacggca acgacatacc cttgacgtcg 47401 cctttcctgg tcacgttgcc agcattgtca acctcgacct cggggccaac ccagctaacg 47461 tcgaaaaaca ccttgacaac catgtttgag ggtgatgggt ggaagaatct ctttgacgca 47521 ggagtggcgt gaaagaatgg agaagaggag ggggaggagg ggagaaaaga gtttctgagg 47581 atggaggggc agctctggaa agtcttcatg gtgggggtgg actgcggggt tc //