Mercurial > repos > iuc > gem_flux_variability_analysis
changeset 0:dfeabe31d865 draft default tip
planemo upload for repository https://github.com/AlmaasLab/elixir-galaxy-tools-systemsbiology commit 3f7bec1264a86e1488ee1315dbac0f44675f5171
| author | iuc |
|---|---|
| date | Fri, 13 Dec 2024 21:34:04 +0000 |
| parents | |
| children | |
| files | gem_escher_visualization.py gem_extract_exchange.py gem_flux_distribution.py gem_flux_variability_analysis.py gem_flux_variability_analysis.xml gem_knockout.py gem_macros.xml gem_phenotype_phase_plane.py test-data/e_coli_core_test_map.json test-data/expected_single_knockout.csv test-data/invalid_format.txt test-data/textbook_model_cobrapy.xml test-data/textbook_model_cobrapy_exchange.csv |
| diffstat | 13 files changed, 19489 insertions(+), 0 deletions(-) [+] |
line wrap: on
line diff
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/gem_escher_visualization.py Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,233 @@ +import argparse + +import cobra +import pandas as pd +from escher import Builder + + +def __main__(): + parser = argparse.ArgumentParser( + prog="EscherVisualization", + description="This program visualizes an Escher map", + epilog="Adding an epilog, but doubt it's needed.", + ) + parser.add_argument( + "-m", + "--cb_model_location", + dest="cb_model_location", + action="store", + type=str, + default=None, + required=False, + help="The model to use." + ) + parser.add_argument( + "-f", + "--flux_distribution_location", + dest="flux_distribution_location", + action="store", + type=str, + default=None, + required=False, + help="The flux distribution to visualize." + ) + parser.add_argument( + "-e", + "--expect_map", + dest="expect_map", + action="store", + type=str, + default=None, + required=True, + help="Is a map expected to be uploaded?" + ) + parser.add_argument( + "-l", + "--model_to_download", + dest="model_to_download", + action="store", + type=str, + default=None, + required=False, + help="The model to download." + ) + parser.add_argument( + "--map_load_name", + dest="map_load_name", + action="store", + type=str, + default=None, + required=False, + help="The name of the map to use." + ) + parser.add_argument( + "--map_upload_name", + dest="map_upload_name", + action="store", + type=str, + default=None, + required=False, + help="The name of the map to use." + ) + parser.add_argument( + "-u", + "--uptake_constraints_file", + dest="uptake_constraints_file", + action="store", + type=str, + default=None, + required=False, + help="File containing new uptake constraits." + ) + parser.add_argument( + "-output", + "--output", + dest="out_file", + action="store", + type=str, + default=None, + required=True, + help="The output file." + ) + + args = parser.parse_args() + + if args.expect_map not in ["True", "False"]: + raise Exception("The expect_map argument must be either True or False.") + if args.expect_map == "True" and args.map_load_name is None and \ + args.map_upload_name is None: + raise Exception( + "You must specify a map name if a map is expected to be uploaded." + ) + + cb_model = None + model_name = None + if args.model_to_download is not None and args.model_to_download != "None": + if args.cb_model_location is not None \ + and args.cb_model_location != "None": + raise Exception( + "You cannot specify both a model to " + "download and a model to use." + ) + model_name = args.model_to_download + elif args.cb_model_location is not None\ + and args.cb_model_location != "None": + try: + cb_model = cobra.io.read_sbml_model(args.cb_model_location) + except Exception as e: + raise Exception( + "The model could not be read. " + "Ensure it is in correct SBML format." + ) from e + + map_name = None + map_location = None + if args.map_upload_name is not None and args.map_upload_name != "None": + if args.map_load_name is not None and args.map_load_name != "None": + raise Exception( + "You cannot specify both a map to upload and a map to load." + ) + map_location = args.map_upload_name + elif args.map_load_name is not None and args.map_load_name != "None": + map_name = args.map_load_name + + if args.uptake_constraints_file is not None and \ + args.uptake_constraints_file != "None": + if cb_model is None: + raise Exception( + "You cannot specify uptake constraints " + "without uploading a model." + ) + else: + constraints_df = pd.read_csv( + args.uptake_constraints_file, + sep=";", + header=0, + index_col=False + ) + for index, row in constraints_df.iterrows(): + rxn_id = row["reaction_id"] + cb_model.reactions.get_by_id(rxn_id).lower_bound = \ + row["lower_bound"] + cb_model.reactions.get_by_id(rxn_id).upper_bound = \ + row["upper_bound"] + + flux_dict = None + if args.flux_distribution_location is not None and \ + args.flux_distribution_location != "None": + if cb_model is None: + raise Exception( + "You cannot specify a flux distribution " + "without uploading a model." + ) + if args.uptake_constraints_file is not None and \ + args.uptake_constraints_file != "None": + raise Exception( + "You cannot specify both uptake constraints and a flux " + "distribution." + ) + try: + flux_df = pd.read_csv( + args.flux_distribution_location, + sep=";", + header=0, + index_col=False + ) + flux_dict = { + key: value for key, value in zip( + flux_df['reaction_name'], + flux_df['flux'] + ) + } + except Exception as e: + raise Exception( + "The flux distribution file could not be read. " + "Ensure the file has semicolon-separated " + "columns and a header row." + ) from e + + if cb_model is not None and flux_dict is None: + solution = cobra.flux_analysis.pfba(cb_model) + + # make a dataframe with the reaction names, reaction ids, and flux + flux_distribution = pd.DataFrame( + columns=["reaction_name", "reaction_id", "flux"] + ) + flux_distribution["reaction_name"] = [ + reaction.name for reaction in cb_model.reactions + ] + flux_distribution["reaction_id"] = [ + reaction.id for reaction in cb_model.reactions + ] + flux_distribution["flux"] = [ + solution.fluxes[reaction.id] for reaction in cb_model.reactions + ] + flux_dict = { + key: value for key, value in zip( + flux_distribution['reaction_name'], + flux_distribution['flux'] + ) + } + + builder = Builder() + if map_name is not None: + builder.map_name = map_name + print("Downloading map...") + if map_location is not None: + builder.map_json = map_location + print("Uploading map...") + if model_name is not None: + builder.model_name = model_name + print("Downloading model...") + if cb_model is not None: + builder.model = cb_model + print("Uploading model...") + + if flux_dict is not None: + builder.reaction_data = flux_dict + + builder.save_html(args.out_file) + + +if __name__ == "__main__": + __main__()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/gem_extract_exchange.py Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,80 @@ +import argparse + +import cobra + + +def read_model(model_location): + model = cobra.io.read_sbml_model(model_location) + return model + + +def get_exchange_reactions_info(model): + exchange_reactions = model.exchanges + exchange_reactions_info = [] + for reaction in exchange_reactions: + exchange_reactions_info.append( + [ + reaction.id, + reaction.name, + reaction.reaction, + reaction.lower_bound, + reaction.upper_bound + ]) + txt_object = ( + "reaction_id;reaction_name;reaction_stoichiometry;" + "lower_bound;upper_bound\n" + ) + for reaction in exchange_reactions_info: + txt_object += ";".join([str(x) for x in reaction]) + "\n" + return txt_object + + +def __main__(): + + # Parsing arguments + parser = argparse.ArgumentParser( + prog="GEM ", + description="This program retrieves the exchange fluxes " + "of a GEM model to be used in Galaxy.", + epilog="Adding an epilog, but doubt it's needed.", + ) + parser.add_argument( + "-m", + "--cb_model_location", + dest="cb_model_location", + action="store", + type=str, + default=None, + required=True, + help="The model to use." + ) + parser.add_argument( + "-output", + "--output", + dest="out_file", + action="store", + type=str, + default=None, + required=True, + help="The output file." + ) + args = parser.parse_args() + + # Reading model from file + try: + cb_model = read_model(args.cb_model_location) + except Exception as e: + raise Exception( + "The model could not be read. Ensure it is in correct SBML format." + ) from e + + # Getting exchange reactions info + answer = get_exchange_reactions_info(cb_model) + + # Writing exchange reactions info to file + with open(args.out_file, "w") as outfile: + outfile.write(str(answer)) + + +if __name__ == "__main__": + __main__()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/gem_flux_distribution.py Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,90 @@ +import argparse + +import cobra +import pandas as pd + + +def __main__(): + parser = argparse.ArgumentParser( + prog="FluxDistribution", + description="This program calculates the flux distribution of a GEM", + epilog="Adding an epilog, but doubt it's needed.", + ) + parser.add_argument( + "-m", + "--cb_model_location", + dest="cb_model_location", + action="store", + type=str, + default=None, + required=True, + help="The model to use." + ) + parser.add_argument( + "-output", + "--output", + dest="out_file", + action="store", + type=str, + default=None, + required=True, + help="The output file." + ) + parser.add_argument( + "-u", + "--uptake_constraints_file", + dest="uptake_constraints_file", + action="store", + type=str, + default=None, + required=False, + help="File containing new uptake constraits." + ) + + args = parser.parse_args() + + try: + cb_model = cobra.io.read_sbml_model(args.cb_model_location) + except Exception as e: + raise Exception( + "The model could not be read. Ensure " + "it is in correct SBML format." + ) from e + + if args.uptake_constraints_file is not None\ + and args.uptake_constraints_file != "None": + constraints_df = pd.read_csv( + args.uptake_constraints_file, + sep=";", + header=0, + index_col=False + ) + for _, row in constraints_df.iterrows(): + cb_model.reactions.get_by_id( + row["reaction_id"] + ).lower_bound = row["lower_bound"] + cb_model.reactions.get_by_id( + row["reaction_id"] + ).upper_bound = row["upper_bound"] + + # do pFBA + solution = cobra.flux_analysis.pfba(cb_model) + + # make a dataframe with the reaction names, + # reaction ids, and flux distribution + flux_distribution = pd.DataFrame( + columns=["reaction_name", "reaction_id", "flux"] + ) + + flux_distribution["reaction_name"] = \ + [reaction.name for reaction in cb_model.reactions] + flux_distribution["reaction_id"] = \ + [reaction.id for reaction in cb_model.reactions] + flux_distribution["flux"] = \ + [solution.fluxes[reaction.id] for reaction in cb_model.reactions] + + flux_distribution.to_csv(args.out_file, sep=";", index=False) + + +if __name__ == "__main__": + __main__()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/gem_flux_variability_analysis.py Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,121 @@ +import argparse + +import cobra +import pandas as pd + + +def __main__(): + parser = argparse.ArgumentParser( + prog="FluxVariabilityAnalysis", + description="This program performs flux variability " + "analysis on a GEM", + epilog="Adding an epilog, but doubt it's needed.", + ) + parser.add_argument( + "-m", "--cb_model_location", + dest="cb_model_location", + action="store", + type=str, + default=None, + required=True, + help="The model to use." + ) + parser.add_argument( + "-output", + "--output", + dest="out_file", + action="store", + type=str, + default=None, + required=True, + help="The output file." + ) + parser.add_argument( + "-f", + "--fraction", + dest="fraction_of_optimum", + action="store", + type=float, + default=None, + required=True, + help="The fraction of optimum the FVA solutions should come within." + ) + parser.add_argument( + "-u", + "--uptake_constraints_file", + dest="uptake_constraints_file", + action="store", + type=str, + default=None, + required=False, + help="File containing new uptake constraits." + ) + + args = parser.parse_args() + + # Validate constraints file first if provided + constraints_df = None + if args.uptake_constraints_file is not None\ + and args.uptake_constraints_file != "None": + try: + constraints_df = pd.read_csv( + args.uptake_constraints_file, + sep=";", + header=0, + index_col=False + ) + + required_columns = ['reaction_id', 'lower_bound', 'upper_bound'] + missing_columns = [col for col in required_columns if + col not in constraints_df.columns] + + if missing_columns: + raise ValueError( + f"Constraints file is missing required columns: " + f"{', '.join(missing_columns)}. " + f"Required columns are: {', '.join(required_columns)}" + ) + except FileNotFoundError: + raise FileNotFoundError( + f"Constraints file not found: {args.uptake_constraints_file}" + ) + except pd.errors.EmptyDataError: + raise ValueError("Constraints file is empty") + except Exception as e: + raise ValueError(f"Error processing constraints file: {str(e)}") + + # Load model + cb_model = cobra.io.read_sbml_model(args.cb_model_location) + + # Apply constraints if they were loaded successfully + if constraints_df is not None: + for index, row in constraints_df.iterrows(): + cb_model.reactions.get_by_id( + row["reaction_id"]).lower_bound = float(row["lower_bound"]) + cb_model.reactions.get_by_id( + row["reaction_id"]).upper_bound = float(row["upper_bound"]) + + fraction_of_optimum = args.fraction_of_optimum + + # perform fva + fva_result = cobra.flux_analysis.flux_variability_analysis( + cb_model, + fraction_of_optimum=fraction_of_optimum + ) + + # add reaction names and ids to the dataframe + fva_result["reaction_id"] = fva_result.index + fva_result["reaction_name"] = fva_result["reaction_id"].apply( + lambda x: cb_model.reactions.get_by_id(x).name + ) + + # reorder the columns + fva_result = fva_result[[ + "reaction_id", "reaction_name", "minimum", "maximum" + ]] + + fva_result.to_csv(args.out_file, sep=";", index=False, header=True) + + +if __name__ == "__main__": + __main__()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/gem_flux_variability_analysis.xml Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,81 @@ +<tool id="gem_flux_variability_analysis" name="Flux variability analysis (FVA)" version="@VERSION@" profile="@PROFILE@"> + <description> + on a GEM + </description> + <macros> + <import>gem_macros.xml</import> + </macros> + <expand macro="requirements"/> + <expand macro="version_command_cobra"/> + <command> + python '$__tool_directory__/gem_flux_variability_analysis.py' + --cb_model_location '${cb_model_location}' + --output '${output}' + --fraction '${fraction_of_optimum}' + --uptake_constraints_file '${uptake_constraints_file}' + </command> + <inputs> + <expand macro="input_model"/> + <param name="fraction_of_optimum" min="0" max="1" type="float" value="0.99" label="Fraction of optimum required in FVA solutions"/> + <expand macro="input_uptake_constraints"/> + </inputs> + <outputs> + <expand macro="output"/> + </outputs> + <tests> + <test> + <param name="cb_model_location" value="textbook_model_cobrapy.xml"/> + <param name="fraction_of_optimum" value="0.99"/> + <output name="output"> + <assert_contents> + <has_line line="reaction_id;reaction_name;minimum;maximum"/> + </assert_contents> + </output> + </test> + <test> + <param name="cb_model_location" value="textbook_model_cobrapy.xml"/> + <param name="fraction_of_optimum" value="0.99"/> + <param name="uptake_constraints_file" value="textbook_model_cobrapy_exchange.csv"/> + <output name="output"> + <assert_contents> + <has_line line="reaction_id;reaction_name;minimum;maximum"/> + </assert_contents> + </output> + </test> + </tests> + <help><![CDATA[ + Flux Variability Analysis (FVA) + + This tool performs Flux Variability Analysis (FVA) on a Genome-scale Metabolic Model (GEM). FVA is a method used to determine the minimum and maximum flux values that each reaction in the network can carry while maintaining a specific objective value. + + Input Parameters + + **Model File**: A GEM in SBML format (.xml) that will be analyzed. + + **Fraction of Optimum**: A value between 0 and 1 that determines how much the objective function can deviate from its optimal value. For example: + - 1.0: Only solutions achieving 100% of optimal objective value + - 0.9: Solutions achieving at least 90% of optimal objective value + - 0.5: Solutions achieving at least 50% of optimal objective value + + **Uptake Constraints File** (optional): A CSV file specifying constraints for exchange reactions. The file should contain columns for exchange reaction IDs and their corresponding bounds. + + Output + + The tool generates a CSV file containing: + - Reaction IDs + - Minimum flux values + - Maximum flux values + for each reaction in the model. + + Common Issues + + - Ensure your model is well-formatted and contains no structural errors + - Check that exchange reactions are properly defined + - Verify that the model is feasible under the given constraints + - Large models may require significant computation time + ]]></help> + <citations> + <expand macro="citation_pandas"/> + <expand macro="citation_cobrapy"/> + </citations> +</tool>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/gem_knockout.py Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,152 @@ +import argparse + +import cobra +import pandas as pd + + +def __main__(): + parser = argparse.ArgumentParser( + prog="FluxDistribution", + description="Performs FBA knockout analysis on a GEM.", + epilog="Adding an epilog, but doubt it's needed.", + ) + parser.add_argument( + "-m", + "--cb_model_location", + dest="cb_model_location", + action="store", + type=str, + default=None, + required=True, + help="The model to use." + ) + parser.add_argument( + "-output", + "--output", + dest="out_file", + action="store", + type=str, + default=None, + required=True, + help="The output file." + ) + parser.add_argument( + "-k", + "--knockout_type", + dest="knockout_type", + action="store", + type=str, + default="single", + required=False, + help="Type of knockout to perform, single or double" + ) + parser.add_argument( + "-g", + "--gene_knockouts", + dest="gene_knockouts", + action="store", + type=str, default=None, + required=False, + help="List of genes to knock out. Defaults to all." + ) + parser.add_argument( + "-u", + "--uptake_constraints_file", + dest="uptake_constraints_file", + action="store", + type=str, + default=None, + required=False, + help="File containing new uptake constraits." + ) + + args = parser.parse_args() + + # Reading the model + try: + cb_model = cobra.io.read_sbml_model(args.cb_model_location) + except Exception as e: + raise Exception( + "The model could not be read. " + "Ensure it is in correct SBML format." + ) from e + + # Verifying the genes are present in the model + gene_ids = [gene.id for gene in cb_model.genes] + + genes_to_knockout_1 = args.gene_knockouts.split(',')\ + if args.gene_knockouts is not None else [] + gene_bool = [ + True if gene in gene_ids else False for gene in genes_to_knockout_1 + ] + if not all(gene_bool): + print( + f'Found {sum(gene_bool)} of {len(genes_to_knockout_1)} genes ' + 'in the model.' + ) + raise Exception( + "One or more of the genes to knockout are not present " + "in the model." + ) + + # Adding all genes to knockout if none are specified + if genes_to_knockout_1 is None or len(genes_to_knockout_1) == 0: + genes_to_knockout_1 = [gene.id for gene in cb_model.genes] + # Applying uptake constraints + if (args.uptake_constraints_file is not None + and args.uptake_constraints_file != "None"): + constraints_df = pd.read_csv( + args.uptake_constraints_file, + sep=";", + header=0, + index_col=False + ) + for index, row in constraints_df.iterrows(): + reaction = cb_model.reactions.get_by_id(row["reaction_id"]) + reaction.lower_bound = row["lower_bound"] + reaction.upper_bound = row["upper_bound"] + + result = pd.DataFrame(columns=[ + "reaction_id", "ko_gene_id_1", "ko_gene_id_2", + "reaction", "wildtype_flux", "knockout_flux" + ]) + + if args.knockout_type == "single": + genes_to_knockout_2 = [0] + elif args.knockout_type == "double": + genes_to_knockout_2 = genes_to_knockout_1.copy() + else: + raise Exception( + f"Invalid knockout type {args.knockout_type}. " + "Only single and double are allowed." + ) + + # Wildtype pFBA + with cb_model as model: + wildtype_solution = model.optimize() + + # Performing gene knockouts + for gene1 in genes_to_knockout_1: + for gene2 in genes_to_knockout_2: + with cb_model as model: + model.genes.get_by_id(gene1).knock_out() + if args.knockout_type == "double": + model.genes.get_by_id(gene2).knock_out() + solution = model.optimize() + for reaction in model.reactions: + result = pd.concat([result, pd.DataFrame([{ + "reaction_id": reaction.id, + "ko_gene_id_1": gene1, + "ko_gene_id_2": gene2 + if args.knockout_type == "double" else None, + "reaction": reaction.reaction, + "wildtype_flux": wildtype_solution.fluxes[reaction.id], + "knockout_flux": solution.fluxes[reaction.id], + }])], ignore_index=True) + + # Writing the results to file + result.to_csv(args.out_file, sep=";", index=False) + + +if __name__ == "__main__": + __main__()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/gem_macros.xml Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,75 @@ +<macros> + <!-- Tokens --> + <token name="@VERSION@">0.29.1</token> + <token name="@PROFILE@">23.0</token> + + <!-- Add version commands for different tools --> + <xml name="version_command_cobra"> + <version_command>echo '@VERSION@'</version_command> + </xml> + + <xml name="version_command_escher"> + <version_command>python -c 'from escher import __version__; print(__version__)'</version_command> + </xml> + + <xml name="version_command_memote"> + <version_command>python -c 'from memote import __version__; print(__version__)'</version_command> + </xml> + + <!-- Version command uses cobra requirement version --> + <xml name="version_command"> + <version_command>echo '@VERSION@'</version_command> + </xml> + + <!-- Setting cobra requirement to use version token --> + <xml name="requirements"> + <requirements> + <requirement type="package" version="@VERSION@">cobra</requirement> + <requirement type="package" version="2.2.3">pandas</requirement> + <requirement type="package" version="0.17.0">memote</requirement> + <requirement type="package" version="1.7.3">escher</requirement> + </requirements> + </xml> + + <!-- Common inputs --> + <xml name="input_model"> + <param format="sbml" name="cb_model_location" type="data" label="Model to analyze"/> + </xml> + + <xml name="input_uptake_constraints"> + <param format="csv" name="uptake_constraints_file" type="data" label="Uptake constraints CSV file" optional="true"/> + </xml> + + <!-- Common outputs --> + <xml name="output"> + <data name="output" format="csv" label="${tool.name} on ${on_string}"/> + </xml> + + <!-- Common test elements --> + <xml name="test_invalid_model"> + <test expect_failure="true"> + <param name="cb_model_location" value="invalid_format.txt"/> + <assert_stderr> + <has_text text="The model could not be read"/> + </assert_stderr> + </test> + </xml> + + <!-- Citations --> + <xml name="citation_cobrapy"> + <citation type="doi">10.1186/1752-0509-7-74</citation> + </xml> + + <xml name="citation_pandas"> + <citation type="doi">10.5281/zenodo.3509134</citation> + </xml> + + <xml name="citation_escher"> + <citation type="doi">10.1371/journal.pcbi.1004321</citation> + </xml> + + <xml name="citation_memote"> + <citation type="doi">10.1038/s41587-020-0446-y</citation> + </xml> + +</macros>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/gem_phenotype_phase_plane.py Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,151 @@ +import argparse + +import cobra +import pandas as pd + + +def __main__(): + parser = argparse.ArgumentParser( + prog="ExpectedGrowthRate", + description="This program calculates the production envelope of a GEM", + epilog="Adding an epilog, but doubt it's needed.", + ) + parser.add_argument( + "-m", + "--cb_model_location", + dest="cb_model_location", + action="store", + type=str, + default=None, + required=True, + help="The model to use." + ) + parser.add_argument( + "-output_csv", + "--output_csv", + dest="out_file_csv", + action="store", + type=str, + default=None, + required=True, + help="The output csv file name." + ) + parser.add_argument( + "-r1", + "--reaction1", + dest="reaction1", + action="store", + type=str, + default=None, + required=True, + help="The first reaction to scan." + ) + parser.add_argument( + "-r2", + "--reaction2", + dest="reaction2", + action="store", + type=str, + default=None, + required=True, + help="The second reaction to scan." + ) + parser.add_argument( + "-p", + "--points", + dest="points", + action="store", + type=int, + default=10, + required=False, + help="The number of points to scan." + ) + parser.add_argument( + "-c", + "--objective", + dest="objective", + action="store", + type=str, + default=None, + required=False, + help="The reaction to use as objective." + ) + parser.add_argument( + "-u", + "--uptake_constraints_file", + dest="uptake_constraints_file", + action="store", + type=str, + default=None, + required=False, + help="The file containing the uptake constraints." + ) + + args = parser.parse_args() + try: + assert len(vars(args)) == 7 + except AssertionError: + raise Exception( + f"{len(vars(args))} arguments were received. 7 were expected." + ) + + try: + cb_model = cobra.io.read_sbml_model(args.cb_model_location) + except Exception as e: + raise Exception( + "The model could not be read. Ensure it is in correct SBML format." + ) from e + + # set the uptake constraints if provided + if (args.uptake_constraints_file is not None + and args.uptake_constraints_file != "None"): + constraints_df = pd.read_csv( + args.uptake_constraints_file, + sep=";", + header=0, + index_col=False + ) + for index, row in constraints_df.iterrows(): + cb_model.reactions.get_by_id(row["reaction_id"])\ + .lower_bound = row["lower_bound"] + cb_model.reactions.get_by_id(row["reaction_id"])\ + .upper_bound = row["upper_bound"] + + # get the reactions + reactions = [args.reaction1, args.reaction2] + + # checking if reactions are in model + for reaction in reactions: + if reaction not in cb_model.reactions: + raise Exception( + f"Reaction {reaction} not found in model " + f"{args.cb_model_location.split('/')[-1]}" + ) + + # get the points + points = args.points + if not isinstance(points, int): + raise Exception("Points must be an integer") + if points < 1: + raise Exception("Must have at least one point in the phase plane") + + # perform phenotype phase plane analysis + if args.objective is not None and args.objective != "None" \ + and args.objective != '': + obj = args.objective + else: + obj = None + + results = cobra.flux_analysis.phenotype_phase_plane.production_envelope( + model=cb_model, + reactions=reactions, + points=points, + objective=obj, + ) + + # save the results + results.to_csv(args.out_file_csv, sep=";", header=True, index=False) + + +if __name__ == "__main__": + __main__()
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/e_coli_core_test_map.json Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,1 @@ +[{"map_name":"e_coli_core.Core metabolism","map_id":"0df3827fde8464e80f455a773a52c274","map_description":"E. coli core metabolic network\nLast Modified Thu Dec 12 2024 23:15:48 GMT+0100 (Central European Standard Time)","homepage":"https://escher.github.io","schema":"https://escher.github.io/escher/jsonschema/1-0-0#"},{"reactions":{"1576693":{"name":"Phosphoglycerate kinase","bigg_id":"PGK","reversibility":true,"label_x":1065,"label_y":2715,"gene_reaction_rule":"b2926","genes":[{"bigg_id":"b2926","name":"pgk"}],"metabolites":[{"coefficient":-1,"bigg_id":"3pg_c"},{"coefficient":1,"bigg_id":"13dpg_c"},{"coefficient":-1,"bigg_id":"atp_c"},{"coefficient":1,"bigg_id":"adp_c"}],"segments":{"291":{"from_node_id":"1576835","to_node_id":"1576836","b1":null,"b2":null},"292":{"from_node_id":"1576836","to_node_id":"1576834","b1":null,"b2":null},"293":{"from_node_id":"1576485","to_node_id":"1576835","b1":{"y":2822.4341649025255,"x":1055},"b2":{"y":2789.230249470758,"x":1055}},"294":{"from_node_id":"1576486","to_node_id":"1576835","b1":{"y":2825,"x":1055},"b2":{"y":2790,"x":1055}},"295":{"from_node_id":"1576834","to_node_id":"1576487","b1":{"y":2650,"x":1055},"b2":{"y":2615,"x":1055}},"296":{"from_node_id":"1576834","to_node_id":"1576488","b1":{"y":2650.769750529242,"x":1055},"b2":{"y":2617.5658350974745,"x":1055}}}},"1576694":{"name":"Phosphogluconate dehydrogenase","bigg_id":"GND","reversibility":false,"label_x":1930.5045166015625,"label_y":1313.710205078125,"gene_reaction_rule":"b2029","genes":[{"bigg_id":"b2029","name":"gnd"}],"metabolites":[{"coefficient":1,"bigg_id":"ru5p__D_c"},{"coefficient":1,"bigg_id":"nadph_c"},{"coefficient":1,"bigg_id":"co2_c"},{"coefficient":-1,"bigg_id":"nadp_c"},{"coefficient":-1,"bigg_id":"6pgc_c"}],"segments":{"297":{"from_node_id":"1576838","to_node_id":"1576837","b1":null,"b2":null},"298":{"from_node_id":"1576837","to_node_id":"1576839","b1":null,"b2":null},"299":{"from_node_id":"1576489","to_node_id":"1576838","b1":{"y":1265,"x":1884.7984674554473},"b2":{"y":1265,"x":1921.339540236634}},"300":{"from_node_id":"1576490","to_node_id":"1576838","b1":{"y":1265,"x":1882},"b2":{"y":1265,"x":1920.5}},"301":{"from_node_id":"1576839","to_node_id":"1576491","b1":{"y":1265,"x":1992.660459763366},"b2":{"y":1265,"x":2029.2015325445527}},"302":{"from_node_id":"1576839","to_node_id":"1576492","b1":{"y":1265,"x":1996.2093727122985},"b2":{"y":1265,"x":2041.0312423743285}},"303":{"from_node_id":"1576839","to_node_id":"1576493","b1":{"y":1265,"x":2003.7},"b2":{"y":1265,"x":2066}}}},"1576695":{"name":"O2 transport diffusion ","bigg_id":"O2t","reversibility":true,"label_x":4557.1943359375,"label_y":1635.4964599609375,"gene_reaction_rule":"s0001","genes":[{"bigg_id":"s0001","name":"None"}],"metabolites":[{"coefficient":1,"bigg_id":"o2_c"},{"coefficient":-1,"bigg_id":"o2_e"}],"segments":{"304":{"from_node_id":"1576494","to_node_id":"1576840","b1":{"y":1660,"x":4821.5},"b2":{"y":1660,"x":4755}},"305":{"from_node_id":"1576840","to_node_id":"1576495","b1":{"y":1660,"x":4610.5},"b2":{"y":1660,"x":4495}}}},"1576696":{"name":"NAD P transhydrogenase","bigg_id":"THD2","reversibility":false,"label_x":3532.891845703125,"label_y":872.8489990234375,"gene_reaction_rule":"b1602 and b1603","genes":[{"bigg_id":"b1602","name":"pntB"},{"bigg_id":"b1603","name":"pntA"}],"metabolites":[{"coefficient":-2,"bigg_id":"h_e"},{"coefficient":-1,"bigg_id":"nadp_c"},{"coefficient":-1,"bigg_id":"nadh_c"},{"coefficient":1,"bigg_id":"nadph_c"},{"coefficient":2,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"nad_c"}],"segments":{"306":{"from_node_id":"1576842","to_node_id":"1576841","b1":null,"b2":null},"307":{"from_node_id":"1576841","to_node_id":"1576843","b1":null,"b2":null},"308":{"from_node_id":"1576496","to_node_id":"1576842","b1":{"y":580.5856339661426,"x":3331.1220703125},"b2":{"y":724.5066228070302,"x":3510}},"309":{"from_node_id":"1576497","to_node_id":"1576842","b1":{"y":654.7419446101471,"x":3418.143798828125},"b2":{"y":750.137689584216,"x":3510}},"310":{"from_node_id":"1576498","to_node_id":"1576842","b1":{"y":725,"x":3510},"b2":{"y":777.5,"x":3510}},"311":{"from_node_id":"1576843","to_node_id":"1576499","b1":{"y":921.2841796875,"x":3510},"b2":{"y":995.287841796875,"x":3510}},"312":{"from_node_id":"1576843","to_node_id":"1576500","b1":{"y":1061.6865465211372,"x":3508.388671875},"b2":{"y":1078.144282674624,"x":3740.4462890625}},"313":{"from_node_id":"1576843","to_node_id":"1576501","b1":{"y":1038.7769502394156,"x":3506.777099609375},"b2":{"y":1081.817596989458,"x":3624.41748046875}}}},"1576697":{"name":"Fumarase","bigg_id":"FUM","reversibility":true,"label_x":2759.057373046875,"label_y":3066,"gene_reaction_rule":"b1612 or b4122 or b1611","genes":[{"bigg_id":"b4122","name":"fumB"},{"bigg_id":"b1611","name":"fumC"},{"bigg_id":"b1612","name":"fumA"}],"metabolites":[{"coefficient":-1,"bigg_id":"fum_c"},{"coefficient":-1,"bigg_id":"h2o_c"},{"coefficient":1,"bigg_id":"mal__L_c"}],"segments":{"314":{"from_node_id":"1576844","to_node_id":"1576845","b1":null,"b2":null},"315":{"from_node_id":"1576845","to_node_id":"1576504","b1":{"y":3093.4,"x":2674.55},"b2":{"y":3134,"x":2652.5}},"316":{"from_node_id":"1576502","to_node_id":"1576844","b1":{"y":2982.216997307231,"x":2758.679057699798},"b2":{"y":3010.0650991921693,"x":2736.5037173099395}},"317":{"from_node_id":"1576503","to_node_id":"1576844","b1":{"y":2961.5818349379524,"x":2775.110761067927},"b2":{"y":3003.8745504813855,"x":2741.433228320378}}}},"1576698":{"name":"Isocitrate dehydrogenase (NADP)","bigg_id":"ICDHyr","reversibility":true,"label_x":3616,"label_y":3836,"gene_reaction_rule":"b1136","genes":[{"bigg_id":"b1136","name":"icd"}],"metabolites":[{"coefficient":1,"bigg_id":"nadph_c"},{"coefficient":1,"bigg_id":"akg_c"},{"coefficient":1,"bigg_id":"co2_c"},{"coefficient":-1,"bigg_id":"nadp_c"},{"coefficient":-1,"bigg_id":"icit_c"}],"segments":{"318":{"from_node_id":"1576847","to_node_id":"1576846","b1":null,"b2":null},"319":{"from_node_id":"1576846","to_node_id":"1576848","b1":null,"b2":null},"320":{"from_node_id":"1576505","to_node_id":"1576847","b1":{"y":3958.5796398057905,"x":3468.565115042282},"b2":{"y":3933.673891941737,"x":3498.9695345126847}},"321":{"from_node_id":"1576506","to_node_id":"1576847","b1":{"y":3968.312968378653,"x":3456.6828697715146},"b2":{"y":3936.593890513596,"x":3495.4048609314546}},"322":{"from_node_id":"1576848","to_node_id":"1576507","b1":{"y":3767.3462919329904,"x":3674.9732516895315},"b2":{"y":3735.4876397766343,"x":3702.9108389651055}},"323":{"from_node_id":"1576848","to_node_id":"1576508","b1":{"y":3771.6386673078805,"x":3671.209168668474},"b2":{"y":3749.7955576929353,"x":3690.36389556158}},"324":{"from_node_id":"1576848","to_node_id":"1576509","b1":{"y":3761.2701283117613,"x":3680.3015797881476},"b2":{"y":3715.2337610392046,"x":3720.671932627159}}}},"1576699":{"name":"Pyruvate dehydrogenase","bigg_id":"PDH","reversibility":false,"label_x":1417.72802734375,"label_y":3920.71923828125,"gene_reaction_rule":"b0114 and b0115 and b0116","genes":[{"bigg_id":"b0114","name":"aceE"},{"bigg_id":"b0115","name":"aceF"},{"bigg_id":"b0116","name":"lpd"}],"metabolites":[{"coefficient":1,"bigg_id":"nadh_c"},{"coefficient":-1,"bigg_id":"coa_c"},{"coefficient":-1,"bigg_id":"pyr_c"},{"coefficient":1,"bigg_id":"accoa_c"},{"coefficient":-1,"bigg_id":"nad_c"},{"coefficient":1,"bigg_id":"co2_c"}],"segments":{"325":{"from_node_id":"1576849","to_node_id":"1576850","b1":null,"b2":null},"326":{"from_node_id":"1576850","to_node_id":"1576851","b1":null,"b2":null},"327":{"from_node_id":"1576510","to_node_id":"1576849","b1":{"y":3945,"x":1374.4909917220637},"b2":{"y":3945,"x":1413.3472975166192}},"328":{"from_node_id":"1576511","to_node_id":"1576849","b1":{"y":3945,"x":1242.5},"b2":{"y":3945,"x":1373.75}},"329":{"from_node_id":"1576512","to_node_id":"1576849","b1":{"y":3945,"x":1369.1210216905704},"b2":{"y":3945,"x":1411.736306507171}},"330":{"from_node_id":"1576851","to_node_id":"1576513","b1":{"y":3945,"x":1570.4434452114806},"b2":{"y":3945,"x":1606.478150704935}},"331":{"from_node_id":"1576851","to_node_id":"1576514","b1":{"y":3945,"x":1579},"b2":{"y":3945,"x":1635}},"332":{"from_node_id":"1576851","to_node_id":"1576515","b1":{"y":3945,"x":1572.492855684536},"b2":{"y":3945,"x":1613.309518948453}}}},"1576700":{"name":"Phosphoenolpyruvate carboxylase","bigg_id":"PPC","reversibility":false,"label_x":1490.0008544921875,"label_y":3479.666748046875,"gene_reaction_rule":"b3956","genes":[{"bigg_id":"b3956","name":"ppc"}],"metabolites":[{"coefficient":-1,"bigg_id":"h2o_c"},{"coefficient":1,"bigg_id":"oaa_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"pep_c"},{"coefficient":1,"bigg_id":"pi_c"},{"coefficient":-1,"bigg_id":"co2_c"}],"segments":{"333":{"from_node_id":"1576854","to_node_id":"1576852","b1":null,"b2":null},"334":{"from_node_id":"1576852","to_node_id":"1576853","b1":null,"b2":null},"335":{"from_node_id":"1576516","to_node_id":"1576854","b1":{"y":3438.769633287661,"x":1302.6712784637714},"b2":{"y":3452.2308899862983,"x":1334.4013835391315}},"336":{"from_node_id":"1576517","to_node_id":"1576854","b1":{"y":3398.5330945780183,"x":1207.828008648186},"b2":{"y":3440.1599283734054,"x":1305.9484025944557}},"337":{"from_node_id":"1576518","to_node_id":"1576854","b1":{"y":3422.409571522363,"x":1264.1082757312843},"b2":{"y":3447.322871456709,"x":1322.8324827193853}},"338":{"from_node_id":"1576853","to_node_id":"1576519","b1":{"y":3526.498358619846,"x":1510.9506160899336},"b2":{"y":3543.994528732819,"x":1552.8353869664456}},"339":{"from_node_id":"1576853","to_node_id":"1576520","b1":{"y":3528.947159164474,"x":1516.81289618162},"b2":{"y":3552.157197214914,"x":1572.3763206054002}},"340":{"from_node_id":"1576853","to_node_id":"1576521","b1":{"y":3708.0419942097856,"x":1966.279649431665},"b2":{"y":3691.624192938869,"x":2580.289220436279}}}},"1576701":{"name":"Enolase","bigg_id":"ENO","reversibility":true,"label_x":1065,"label_y":3215,"gene_reaction_rule":"b2779","genes":[{"bigg_id":"b2779","name":"eno"}],"metabolites":[{"coefficient":1,"bigg_id":"pep_c"},{"coefficient":1,"bigg_id":"h2o_c"},{"coefficient":-1,"bigg_id":"2pg_c"}],"segments":{"341":{"from_node_id":"1576522","to_node_id":"1576856","b1":{"y":3173.322021484375,"x":1055},"b2":{"y":3175,"x":1055}},"342":{"from_node_id":"1576856","to_node_id":"1576855","b1":null,"b2":null},"343":{"from_node_id":"1576855","to_node_id":"1576517","b1":{"y":3281.5,"x":1055},"b2":{"y":3320,"x":1055}},"344":{"from_node_id":"1576855","to_node_id":"1576523","b1":{"y":3281.224980739588,"x":1055},"b2":{"y":3319.0832691319597,"x":1055}}}},"1576702":{"name":"Glucose-6-phosphate isomerase","bigg_id":"PGI","reversibility":true,"label_x":1065,"label_y":1385,"gene_reaction_rule":"b4025","genes":[{"bigg_id":"b4025","name":"pgi"}],"metabolites":[{"coefficient":-1,"bigg_id":"g6p_c"},{"coefficient":1,"bigg_id":"f6p_c"}],"segments":{"345":{"from_node_id":"1576524","to_node_id":"1576857","b1":{"y":1284.5,"x":1055},"b2":{"y":1330,"x":1055}},"346":{"from_node_id":"1576857","to_node_id":"1576525","b1":{"y":1417.5,"x":1055},"b2":{"y":1470,"x":1055}}}},"1576703":{"name":"Ammonia reversible transport","bigg_id":"NH4t","reversibility":true,"label_x":3999,"label_y":4588,"gene_reaction_rule":"s0001 or b0451","genes":[{"bigg_id":"b0451","name":"amtB"},{"bigg_id":"s0001","name":"None"}],"metabolites":[{"coefficient":-1,"bigg_id":"nh4_e"},{"coefficient":1,"bigg_id":"nh4_c"}],"segments":{"347":{"from_node_id":"1576526","to_node_id":"1576858","b1":{"y":4733.15,"x":3989},"b2":{"y":4677.5,"x":3989}},"348":{"from_node_id":"1576858","to_node_id":"1576527","b1":{"y":4574.45,"x":3989},"b2":{"y":4519.5,"x":3989}}}},"1576704":{"name":"Fructose-bisphosphatase","bigg_id":"FBP","reversibility":false,"label_x":751.3809814453125,"label_y":1733.561767578125,"gene_reaction_rule":"b3925 or b4232","genes":[{"bigg_id":"b4232","name":"fbp"},{"bigg_id":"b3925","name":"glpX"}],"metabolites":[{"coefficient":-1,"bigg_id":"fdp_c"},{"coefficient":-1,"bigg_id":"h2o_c"},{"coefficient":1,"bigg_id":"pi_c"},{"coefficient":1,"bigg_id":"f6p_c"}],"segments":{"349":{"from_node_id":"1576861","to_node_id":"1576859","b1":null,"b2":null},"350":{"from_node_id":"1576859","to_node_id":"1576860","b1":null,"b2":null},"351":{"from_node_id":"1576528","to_node_id":"1576861","b1":{"y":1822.0087712549569,"x":835},"b2":{"y":1782.1026313764871,"x":835}},"352":{"from_node_id":"1576529","to_node_id":"1576861","b1":{"y":1901.0147050873545,"x":835},"b2":{"y":1805.8044115262064,"x":835}},"353":{"from_node_id":"1576860","to_node_id":"1576525","b1":{"y":1627.410107741575,"x":835},"b2":{"y":1539.7003591385833,"x":835}},"354":{"from_node_id":"1576860","to_node_id":"1576530","b1":{"y":1645.7906272877015,"x":835},"b2":{"y":1600.9687576256715,"x":835}}}},"1576705":{"name":"Succinate exchange","bigg_id":"EX_succ_e","reversibility":false,"label_x":4968.927734375,"label_y":2845.8271484375,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"succ_e"}],"segments":{"355":{"from_node_id":"1576531","to_node_id":"1576863","b1":{"y":2880,"x":4945.95},"b2":{"y":2880,"x":4978.5}}}},"1576706":{"name":"Isocitrate lyase","bigg_id":"ICL","reversibility":false,"label_x":3427,"label_y":3847,"gene_reaction_rule":"b4015","genes":[{"bigg_id":"b4015","name":"aceA"}],"metabolites":[{"coefficient":1,"bigg_id":"succ_c"},{"coefficient":1,"bigg_id":"glx_c"},{"coefficient":-1,"bigg_id":"icit_c"}],"segments":{"357":{"from_node_id":"1576505","to_node_id":"1576865","b1":{"y":3958.15,"x":3413.6},"b2":{"y":3916.5,"x":3415}},"358":{"from_node_id":"1576865","to_node_id":"1576864","b1":null,"b2":null},"359":{"from_node_id":"1576864","to_node_id":"1576532","b1":{"y":3719.8679883378145,"x":3417},"b2":{"y":3612.2266277927156,"x":3417}},"360":{"from_node_id":"1576864","to_node_id":"1576533","b1":{"y":3631.14924916783,"x":3417},"b2":{"y":3316.4974972260998,"x":3417}}}},"1576707":{"name":"Adenylate kinase","bigg_id":"ADK1","reversibility":true,"label_x":3997.07177734375,"label_y":1251.6114501953125,"gene_reaction_rule":"b0474","genes":[{"bigg_id":"b0474","name":"adk"}],"metabolites":[{"coefficient":-1,"bigg_id":"amp_c"},{"coefficient":-1,"bigg_id":"atp_c"},{"coefficient":2,"bigg_id":"adp_c"}],"segments":{"361":{"from_node_id":"1576867","to_node_id":"1576866","b1":null,"b2":null},"362":{"from_node_id":"1576866","to_node_id":"1576536","b1":{"y":1352.2913818359375,"x":4145.83056640625},"b2":{"y":1441.4029541015625,"x":4146.15869140625}},"363":{"from_node_id":"1576534","to_node_id":"1576867","b1":{"y":1112.6787540171351,"x":4145},"b2":{"y":1173.8036262051405,"x":4145}},"364":{"from_node_id":"1576535","to_node_id":"1576867","b1":{"y":1123.6783123876312,"x":4145},"b2":{"y":1177.1034937162894,"x":4145}}}},"1576708":{"name":"L-Glutamine exchange","bigg_id":"EX_gln__L_e","reversibility":false,"label_x":4933.3095703125,"label_y":4131.884765625,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"gln__L_e"}],"segments":{"365":{"from_node_id":"1576537","to_node_id":"1576868","b1":{"y":4158,"x":4902.7},"b2":{"y":4158,"x":4951}}}},"1576710":{"name":"CO2 exchange","bigg_id":"EX_co2_e","reversibility":true,"label_x":3631,"label_y":4904,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"co2_e"}],"segments":{"367":{"from_node_id":"1576544","to_node_id":"1576871","b1":{"y":4778,"x":3621},"b2":{"y":4834,"x":3621}}}},"1576711":{"name":"Transaldolase","bigg_id":"TALA","reversibility":true,"label_x":2197.5205078125,"label_y":2008.8013916015625,"gene_reaction_rule":"b2464 or b0008","genes":[{"bigg_id":"b2464","name":"talA"},{"bigg_id":"b0008","name":"talB"}],"metabolites":[{"coefficient":-1,"bigg_id":"s7p_c"},{"coefficient":-1,"bigg_id":"g3p_c"},{"coefficient":1,"bigg_id":"f6p_c"},{"coefficient":1,"bigg_id":"e4p_c"}],"segments":{"369":{"from_node_id":"1576873","to_node_id":"1576872","b1":null,"b2":null},"370":{"from_node_id":"1576872","to_node_id":"1576874","b1":null,"b2":null},"371":{"from_node_id":"1576545","to_node_id":"1576873","b1":{"y":1892.1518443631908,"x":2283.184776999114},"b2":{"y":1856.1727017464573,"x":2173.815906732547}},"372":{"from_node_id":"1576546","to_node_id":"1576873","b1":{"y":1890.5651744413158,"x":2064.2112662569266},"b2":{"y":1856.1728238167698,"x":2175.402576654422}},"373":{"from_node_id":"1576874","to_node_id":"1576547","b1":{"y":2076.976957965055,"x":2178},"b2":{"y":2171.7496092324754,"x":2178}},"374":{"from_node_id":"1576874","to_node_id":"1576548","b1":{"y":2077.4778177405574,"x":2178},"b2":{"y":2170.2455578331073,"x":2178.000244140625}}}},"1576712":{"name":"Pyruvate kinase","bigg_id":"PYK","reversibility":false,"label_x":1065,"label_y":3695,"gene_reaction_rule":"b1854 or b1676","genes":[{"bigg_id":"b1854","name":"pykA"},{"bigg_id":"b1676","name":"pykF"}],"metabolites":[{"coefficient":-1,"bigg_id":"pep_c"},{"coefficient":-1,"bigg_id":"adp_c"},{"coefficient":1,"bigg_id":"pyr_c"},{"coefficient":1,"bigg_id":"atp_c"},{"coefficient":-1,"bigg_id":"h_c"}],"segments":{"375":{"from_node_id":"1576875","to_node_id":"1576876","b1":null,"b2":null},"376":{"from_node_id":"1576876","to_node_id":"1576877","b1":null,"b2":null},"377":{"from_node_id":"1576549","to_node_id":"1576875","b1":{"y":3607.5658350974745,"x":1055},"b2":{"y":3640.769750529242,"x":1055}},"378":{"from_node_id":"1576550","to_node_id":"1576875","b1":{"y":3587.7318797646312,"x":1055},"b2":{"y":3634.8195639293895,"x":1055}},"379":{"from_node_id":"1576517","to_node_id":"1576875","b1":{"y":3515,"x":1055},"b2":{"y":3613,"x":1055}},"380":{"from_node_id":"1576877","to_node_id":"1576511","b1":{"y":3775,"x":1055},"b2":{"y":3845,"x":1055}},"381":{"from_node_id":"1576877","to_node_id":"1576551","b1":{"y":3762.102631376487,"x":1055},"b2":{"y":3802.008771254957,"x":1055}}}},"1576713":{"name":"L glutamate transport via proton symport reversible","bigg_id":"GLUt2r","reversibility":true,"label_x":4655,"label_y":3625,"gene_reaction_rule":"b4077","genes":[{"bigg_id":"b4077","name":"gltP"}],"metabolites":[{"coefficient":1,"bigg_id":"glu__L_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"glu__L_e"},{"coefficient":-1,"bigg_id":"h_e"}],"segments":{"382":{"from_node_id":"1576880","to_node_id":"1576878","b1":null,"b2":null},"383":{"from_node_id":"1576878","to_node_id":"1576879","b1":null,"b2":null},"384":{"from_node_id":"1576552","to_node_id":"1576880","b1":{"y":3635,"x":4831.002403790594},"b2":{"y":3635,"x":4794.600721137178}},"385":{"from_node_id":"1576553","to_node_id":"1576880","b1":{"y":3635,"x":4820.0487515035475},"b2":{"y":3635,"x":4791.314625451064}},"386":{"from_node_id":"1576879","to_node_id":"1576554","b1":{"y":3635,"x":4497.047696306109},"b2":{"y":3635,"x":4394.492321020364}},"387":{"from_node_id":"1576879","to_node_id":"1576555","b1":{"y":3635,"x":4528.650708522348},"b2":{"y":3635,"x":4499.835695074495}}}},"1576714":{"name":"D-lactate exchange","bigg_id":"EX_lac__D_e","reversibility":false,"label_x":1065,"label_y":4915,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"lac__D_e"}],"segments":{"388":{"from_node_id":"1576556","to_node_id":"1576881","b1":{"y":4861.19384765625,"x":1055},"b2":{"y":4880,"x":1055}}}},"1576715":{"name":"Pyruvate exchange","bigg_id":"EX_pyr_e","reversibility":false,"label_x":96.76921081542969,"label_y":3904.851318359375,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"pyr_e"}],"segments":{"390":{"from_node_id":"1576557","to_node_id":"1576884","b1":{"y":3945,"x":257},"b2":{"y":3945,"x":215}}}},"1576716":{"name":"Ribulose 5-phosphate 3-epimerase","bigg_id":"RPE","reversibility":true,"label_x":1937.57958984375,"label_y":1422.4544677734375,"gene_reaction_rule":"b3386 or b4301","genes":[{"bigg_id":"b4301","name":"sgcE"},{"bigg_id":"b3386","name":"rpe"}],"metabolites":[{"coefficient":1,"bigg_id":"xu5p__D_c"},{"coefficient":-1,"bigg_id":"ru5p__D_c"}],"segments":{"392":{"from_node_id":"1576493","to_node_id":"1576885","b1":{"y":1287.5,"x":2138.5},"b2":{"y":1340,"x":2100}},"393":{"from_node_id":"1576885","to_node_id":"1576558","b1":{"y":1436,"x":2030},"b2":{"y":1485,"x":1995}}}},"1576717":{"name":"H+ exchange","bigg_id":"EX_h_e","reversibility":true,"label_x":4920.2587890625,"label_y":2195.827392578125,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"h_e"}],"segments":{"394":{"from_node_id":"1576559","to_node_id":"1576887","b1":{"y":2229.15,"x":4870.4},"b2":{"y":2229.5,"x":4918}}}},"1576720":{"name":"Succinyl-CoA synthetase (ADP-forming)","bigg_id":"SUCOAS","reversibility":true,"label_x":3641,"label_y":3010,"gene_reaction_rule":"b0728 and b0729","genes":[{"bigg_id":"b0729","name":"sucD"},{"bigg_id":"b0728","name":"sucC"}],"metabolites":[{"coefficient":-1,"bigg_id":"coa_c"},{"coefficient":1,"bigg_id":"adp_c"},{"coefficient":-1,"bigg_id":"succ_c"},{"coefficient":-1,"bigg_id":"atp_c"},{"coefficient":1,"bigg_id":"succoa_c"},{"coefficient":1,"bigg_id":"pi_c"}],"segments":{"396":{"from_node_id":"1576889","to_node_id":"1576888","b1":null,"b2":null},"397":{"from_node_id":"1576888","to_node_id":"1576890","b1":null,"b2":null},"398":{"from_node_id":"1576567","to_node_id":"1576889","b1":{"y":2929.871811487667,"x":3542.920179408402},"b2":{"y":2962.1615434463,"x":3574.4760538225205}},"399":{"from_node_id":"1576568","to_node_id":"1576889","b1":{"y":2939.079434763476,"x":3551.9185385188516},"b2":{"y":2964.923830429043,"x":3577.1755615556553}},"400":{"from_node_id":"1576533","to_node_id":"1576889","b1":{"y":2904.387472959949,"x":3518.015030392677},"b2":{"y":2954.5162418879845,"x":3567.004509117803}},"401":{"from_node_id":"1576890","to_node_id":"1576569","b1":{"y":3077.95608535897,"x":3678.1735578503244},"b2":{"y":3112.853617863234,"x":3706.5785261677484}},"402":{"from_node_id":"1576890","to_node_id":"1576570","b1":{"y":3080.344738078292,"x":3680.117810063726},"b2":{"y":3120.815793594307,"x":3713.059366879087}},"403":{"from_node_id":"1576890","to_node_id":"1576571","b1":{"y":3076.3723735708613,"x":3676.8844901158172},"b2":{"y":3107.574578569538,"x":3702.2816337193913}}}},"1576721":{"name":"Phosphofructokinase","bigg_id":"PFK","reversibility":false,"label_x":1065,"label_y":1725,"gene_reaction_rule":"b3916 or b1723","genes":[{"bigg_id":"b1723","name":"pfkB"},{"bigg_id":"b3916","name":"pfkA"}],"metabolites":[{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"adp_c"},{"coefficient":-1,"bigg_id":"f6p_c"},{"coefficient":-1,"bigg_id":"atp_c"},{"coefficient":1,"bigg_id":"fdp_c"}],"segments":{"404":{"from_node_id":"1576893","to_node_id":"1576891","b1":null,"b2":null},"405":{"from_node_id":"1576891","to_node_id":"1576892","b1":null,"b2":null},"406":{"from_node_id":"1576525","to_node_id":"1576893","b1":{"y":1617.5,"x":1055},"b2":{"y":1668.25,"x":1055}},"407":{"from_node_id":"1576572","to_node_id":"1576893","b1":{"y":1639.6884705062548,"x":1055},"b2":{"y":1674.9065411518764,"x":1055}},"408":{"from_node_id":"1576892","to_node_id":"1576573","b1":{"y":1789.2302494707578,"x":1055},"b2":{"y":1822.4341649025257,"x":1055}},"409":{"from_node_id":"1576892","to_node_id":"1576529","b1":{"y":1797.5,"x":1055},"b2":{"y":1850,"x":1055}},"410":{"from_node_id":"1576892","to_node_id":"1576574","b1":{"y":1793.0623918681883,"x":1055},"b2":{"y":1835.2079728939614,"x":1055}}}},"1576722":{"name":"L-Glutamate exchange","bigg_id":"EX_glu__L_e","reversibility":false,"label_x":4936.36669921875,"label_y":3680.79150390625,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"glu__L_e"}],"segments":{"411":{"from_node_id":"1576552","to_node_id":"1576895","b1":{"y":3634.3,"x":4902.8},"b2":{"y":3635,"x":4949}}}},"1576723":{"name":"Transketolase","bigg_id":"TKT2","reversibility":true,"label_x":1520.71923828125,"label_y":1702.785400390625,"gene_reaction_rule":"b2935 or b2465","genes":[{"bigg_id":"b2465","name":"tktB"},{"bigg_id":"b2935","name":"tktA"}],"metabolites":[{"coefficient":-1,"bigg_id":"xu5p__D_c"},{"coefficient":-1,"bigg_id":"e4p_c"},{"coefficient":1,"bigg_id":"g3p_c"},{"coefficient":1,"bigg_id":"f6p_c"}],"segments":{"413":{"from_node_id":"1576897","to_node_id":"1576896","b1":null,"b2":null},"414":{"from_node_id":"1576896","to_node_id":"1576898","b1":null,"b2":null},"415":{"from_node_id":"1576547","to_node_id":"1576897","b1":{"y":1735,"x":1954.5789860524153},"b2":{"y":1735,"x":1772.8736958157247}},"416":{"from_node_id":"1576558","to_node_id":"1576897","b1":{"y":1735,"x":1849.0292180074937},"b2":{"y":1735,"x":1741.208765402248}},"417":{"from_node_id":"1576898","to_node_id":"1576525","b1":{"y":1741.3470458984375,"x":1235.776382408843},"b2":{"y":1587.43115234375,"x":1280.4546812716637}},"418":{"from_node_id":"1576898","to_node_id":"1576575","b1":{"y":1735,"x":1318.2979239002893},"b2":{"y":1735,"x":1312.7516245895065}}}},"1576724":{"name":"Glutamine synthetase","bigg_id":"GLNS","reversibility":false,"label_x":4377.22314453125,"label_y":3875.114990234375,"gene_reaction_rule":"b3870 or b1297","genes":[{"bigg_id":"b3870","name":"glnA"},{"bigg_id":"b1297","name":"puuA"}],"metabolites":[{"coefficient":-1,"bigg_id":"glu__L_c"},{"coefficient":-1,"bigg_id":"atp_c"},{"coefficient":-1,"bigg_id":"nh4_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"adp_c"},{"coefficient":1,"bigg_id":"pi_c"},{"coefficient":1,"bigg_id":"gln__L_c"}],"segments":{"419":{"from_node_id":"1576901","to_node_id":"1576900","b1":null,"b2":null},"420":{"from_node_id":"1576900","to_node_id":"1576899","b1":null,"b2":null},"421":{"from_node_id":"1576554","to_node_id":"1576901","b1":{"y":3725.970531985219,"x":4364},"b2":{"y":3812.091159595566,"x":4364}},"422":{"from_node_id":"1576576","to_node_id":"1576901","b1":{"y":3788.5599470549537,"x":4364},"b2":{"y":3830.8679841164862,"x":4364}},"423":{"from_node_id":"1576577","to_node_id":"1576901","b1":{"y":3805.0910031997996,"x":4364},"b2":{"y":3835.8273009599397,"x":4364}},"424":{"from_node_id":"1576899","to_node_id":"1576578","b1":{"y":3924.4803114416995,"x":4364},"b2":{"y":4007.2677048056653,"x":4364}},"425":{"from_node_id":"1576899","to_node_id":"1576579","b1":{"y":3903.3287298809073,"x":4364},"b2":{"y":3936.762432936357,"x":4364}},"426":{"from_node_id":"1576899","to_node_id":"1576580","b1":{"y":3909.1943680267545,"x":4364},"b2":{"y":3956.314560089181,"x":4364}},"427":{"from_node_id":"1576899","to_node_id":"1576581","b1":{"y":3915.8851724934025,"x":4364},"b2":{"y":3978.617241644675,"x":4364}}}},"1576726":{"name":"NAD transhydrogenase","bigg_id":"NADTRHD","reversibility":false,"label_x":3478.431396484375,"label_y":1319.6259765625,"gene_reaction_rule":"b3962 or (b1602 and b1603)","genes":[{"bigg_id":"b1602","name":"pntB"},{"bigg_id":"b3962","name":"sthA"},{"bigg_id":"b1603","name":"pntA"}],"metabolites":[{"coefficient":1,"bigg_id":"nadh_c"},{"coefficient":1,"bigg_id":"nadp_c"},{"coefficient":-1,"bigg_id":"nad_c"},{"coefficient":-1,"bigg_id":"nadph_c"}],"segments":{"434":{"from_node_id":"1576906","to_node_id":"1576907","b1":null,"b2":null},"435":{"from_node_id":"1576907","to_node_id":"1576905","b1":null,"b2":null},"436":{"from_node_id":"1576501","to_node_id":"1576906","b1":{"y":1270.0001220703125,"x":3627.146913797642},"b2":{"y":1270,"x":3592.9455878111676}},"437":{"from_node_id":"1576500","to_node_id":"1576906","b1":{"y":1270,"x":3655},"b2":{"y":1270,"x":3595.5}},"438":{"from_node_id":"1576905","to_node_id":"1576496","b1":{"y":1270,"x":3449},"b2":{"y":1270,"x":3400}},"439":{"from_node_id":"1576905","to_node_id":"1576497","b1":{"y":1270,"x":3446.2829175487373},"b2":{"y":1270,"x":3418.3388104489154}}}},"1576727":{"name":"2-Oxogluterate dehydrogenase","bigg_id":"AKGDH","reversibility":false,"label_x":3793,"label_y":3392,"gene_reaction_rule":"b0116 and b0726 and b0727","genes":[{"bigg_id":"b0116","name":"lpd"},{"bigg_id":"b0726","name":"sucA"},{"bigg_id":"b0727","name":"sucB"}],"metabolites":[{"coefficient":1,"bigg_id":"nadh_c"},{"coefficient":-1,"bigg_id":"coa_c"},{"coefficient":-1,"bigg_id":"nad_c"},{"coefficient":1,"bigg_id":"co2_c"},{"coefficient":1,"bigg_id":"succoa_c"},{"coefficient":-1,"bigg_id":"akg_c"}],"segments":{"440":{"from_node_id":"1576908","to_node_id":"1576909","b1":null,"b2":null},"441":{"from_node_id":"1576909","to_node_id":"1576910","b1":null,"b2":null},"442":{"from_node_id":"1576509","to_node_id":"1576908","b1":{"y":3555.384636544082,"x":3777.1005909021505},"b2":{"y":3502.6153909632244,"x":3779.130177270645}},"443":{"from_node_id":"1576585","to_node_id":"1576908","b1":{"y":3529.6925257925727,"x":3778.088749007978},"b2":{"y":3494.907757737772,"x":3779.4266247023934}},"444":{"from_node_id":"1576586","to_node_id":"1576908","b1":{"y":3541.8008905587553,"x":3777.623042670817},"b2":{"y":3498.5402671676266,"x":3779.2869128012453}},"445":{"from_node_id":"1576910","to_node_id":"1576570","b1":{"y":3308.813629813628,"x":3773.940214009658},"b2":{"y":3259.378766045427,"x":3769.134046698861}},"446":{"from_node_id":"1576910","to_node_id":"1576587","b1":{"y":3314.1710953857196,"x":3774.4610787180563},"b2":{"y":3277.236984619066,"x":3770.8702623935205}},"447":{"from_node_id":"1576910","to_node_id":"1576588","b1":{"y":3314.098040676123,"x":3774.453976176845},"b2":{"y":3276.99346892041,"x":3770.846587256151}}}},"1576728":{"name":"Pyruvate formate lyase","bigg_id":"PFL","reversibility":false,"label_x":1310.09130859375,"label_y":4046.8837890625,"gene_reaction_rule":"((b0902 and b0903) and b2579) or (b0902 and b0903) or (b0902 and b3114) or (b3951 and b3952)","genes":[{"bigg_id":"b3114","name":"tdcE"},{"bigg_id":"b3951","name":"pflD"},{"bigg_id":"b3952","name":"pflC"},{"bigg_id":"b0903","name":"pflB"},{"bigg_id":"b0902","name":"pflA"},{"bigg_id":"b2579","name":"grcA"}],"metabolites":[{"coefficient":-1,"bigg_id":"pyr_c"},{"coefficient":-1,"bigg_id":"coa_c"},{"coefficient":1,"bigg_id":"accoa_c"},{"coefficient":1,"bigg_id":"for_c"}],"segments":{"448":{"from_node_id":"1576912","to_node_id":"1576911","b1":null,"b2":null},"449":{"from_node_id":"1576911","to_node_id":"1576913","b1":null,"b2":null},"450":{"from_node_id":"1576589","to_node_id":"1576912","b1":{"y":3995,"x":1203.521849295065},"b2":{"y":3995,"x":1239.5565547885194}},"451":{"from_node_id":"1576511","to_node_id":"1576912","b1":{"y":3995,"x":1151.9223593595584},"b2":{"y":3995,"x":1224.0767078078675}},"452":{"from_node_id":"1576913","to_node_id":"1576514","b1":{"y":3995,"x":1460.6207189772367},"b2":{"y":3995,"x":1567.0690632574556}},"453":{"from_node_id":"1576913","to_node_id":"1576590","b1":{"y":3995,"x":1431.4487841495961},"b2":{"y":3995,"x":1469.8292804986534}}}},"1576729":{"name":"O2 exchange","bigg_id":"EX_o2_e","reversibility":true,"label_x":4894.58984375,"label_y":1633.8848876953125,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"o2_e"}],"segments":{"454":{"from_node_id":"1576494","to_node_id":"1576914","b1":{"y":1660,"x":4868},"b2":{"y":1660,"x":4910}}}},"1576730":{"name":"Phosphoenolpyruvate carboxykinase","bigg_id":"PPCK","reversibility":false,"label_x":1377.3328857421875,"label_y":3600.33447265625,"gene_reaction_rule":"b3403","genes":[{"bigg_id":"b3403","name":"pck"}],"metabolites":[{"coefficient":1,"bigg_id":"pep_c"},{"coefficient":-1,"bigg_id":"atp_c"},{"coefficient":-1,"bigg_id":"oaa_c"},{"coefficient":1,"bigg_id":"co2_c"},{"coefficient":1,"bigg_id":"adp_c"}],"segments":{"456":{"from_node_id":"1576917","to_node_id":"1576916","b1":null,"b2":null},"457":{"from_node_id":"1576916","to_node_id":"1576918","b1":null,"b2":null},"458":{"from_node_id":"1576591","to_node_id":"1576917","b1":{"y":3566.049568601064,"x":1519.8576805959353},"b2":{"y":3557.6148705803193,"x":1495.4573041787805}},"459":{"from_node_id":"1576521","to_node_id":"1576917","b1":{"y":3758.886258987647,"x":2521.6033016696215},"b2":{"y":3678.777694102544,"x":1757.8986662821364}},"460":{"from_node_id":"1576918","to_node_id":"1576592","b1":{"y":3499.9025817202064,"x":1325.707745160619},"b2":{"y":3492.675272400688,"x":1304.0258172020633}},"461":{"from_node_id":"1576918","to_node_id":"1576593","b1":{"y":3497.2795105104547,"x":1317.8385315313635},"b2":{"y":3483.931701701515,"x":1277.7951051045454}},"462":{"from_node_id":"1576918","to_node_id":"1576517","b1":{"y":3488.3964387904866,"x":1291.1893163714603},"b2":{"y":3454.321462634956,"x":1188.9643879048676}}}},"1576731":{"name":"Phosphate reversible transport via symport","bigg_id":"PIt2r","reversibility":true,"label_x":2916.97509765625,"label_y":4649.33837890625,"gene_reaction_rule":"b2987 or b3493","genes":[{"bigg_id":"b3493","name":"pitA"},{"bigg_id":"b2987","name":"pitB"}],"metabolites":[{"coefficient":-1,"bigg_id":"h_e"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"pi_c"},{"coefficient":-1,"bigg_id":"pi_e"}],"segments":{"463":{"from_node_id":"1576921","to_node_id":"1576920","b1":null,"b2":null},"464":{"from_node_id":"1576920","to_node_id":"1576919","b1":null,"b2":null},"465":{"from_node_id":"1576594","to_node_id":"1576921","b1":{"y":4782,"x":2880},"b2":{"y":4742.1,"x":2880}},"466":{"from_node_id":"1576595","to_node_id":"1576921","b1":{"y":4775.936234646861,"x":2880},"b2":{"y":4740.280870394058,"x":2880}},"467":{"from_node_id":"1576919","to_node_id":"1576596","b1":{"y":4503.436712282883,"x":2880},"b2":{"y":4464.789040942943,"x":2880}},"468":{"from_node_id":"1576919","to_node_id":"1576597","b1":{"y":4506.5,"x":2880},"b2":{"y":4475,"x":2880}}}},"1576732":{"name":"2 oxoglutarate reversible transport via symport","bigg_id":"AKGt2r","reversibility":true,"label_x":4594.6474609375,"label_y":3197.05029296875,"gene_reaction_rule":"b2587","genes":[{"bigg_id":"b2587","name":"kgtP"}],"metabolites":[{"coefficient":-1,"bigg_id":"h_e"},{"coefficient":1,"bigg_id":"akg_c"},{"coefficient":-1,"bigg_id":"akg_e"},{"coefficient":1,"bigg_id":"h_c"}],"segments":{"469":{"from_node_id":"1576923","to_node_id":"1576924","b1":null,"b2":null},"470":{"from_node_id":"1576924","to_node_id":"1576922","b1":null,"b2":null},"471":{"from_node_id":"1576598","to_node_id":"1576923","b1":{"y":3228,"x":4857},"b2":{"y":3228,"x":4811.5}},"472":{"from_node_id":"1576599","to_node_id":"1576923","b1":{"y":3228,"x":4843.0220540550845},"b2":{"y":3228,"x":4807.306616216525}},"473":{"from_node_id":"1576922","to_node_id":"1576509","b1":{"y":3228,"x":4373.7752656466},"b2":{"y":3228,"x":4074.584218822}},"474":{"from_node_id":"1576922","to_node_id":"1576600","b1":{"y":3228,"x":4486.339540236634},"b2":{"y":3228,"x":4449.798467455447}}}},"1576733":{"name":"Fructose-bisphosphate aldolase","bigg_id":"FBA","reversibility":true,"label_x":969.7942504882812,"label_y":2031.01611328125,"gene_reaction_rule":"b2097 or b1773 or b2925","genes":[{"bigg_id":"b2097","name":"fbaB"},{"bigg_id":"b2925","name":"fbaA"},{"bigg_id":"b1773","name":"ydjI"}],"metabolites":[{"coefficient":1,"bigg_id":"dhap_c"},{"coefficient":1,"bigg_id":"g3p_c"},{"coefficient":-1,"bigg_id":"fdp_c"}],"segments":{"53":{"from_node_id":"1576926","to_node_id":"1576925","b1":null,"b2":null},"54":{"from_node_id":"1576925","to_node_id":"1576575","b1":{"y":2067.5,"x":1055},"b2":{"y":2120,"x":1055}},"55":{"from_node_id":"1576925","to_node_id":"1576601","b1":{"y":2082.5,"x":1055},"b2":{"y":2081.141357421875,"x":929.645751953125}},"475":{"from_node_id":"1576529","to_node_id":"1576926","b1":{"y":1970.4088134765625,"x":1055},"b2":{"y":1974.28076171875,"x":1055}}}},"1576734":{"name":"Triose-phosphate isomerase","bigg_id":"TPI","reversibility":true,"label_x":936.438232421875,"label_y":2245.297119140625,"gene_reaction_rule":"b3919","genes":[{"bigg_id":"b3919","name":"tpiA"}],"metabolites":[{"coefficient":-1,"bigg_id":"dhap_c"},{"coefficient":1,"bigg_id":"g3p_c"}],"segments":{"56":{"from_node_id":"1576601","to_node_id":"1576927","b1":{"y":2195,"x":911.255859375},"b2":{"y":2195,"x":911.3470458984375}},"57":{"from_node_id":"1576927","to_node_id":"1576575","b1":{"y":2195,"x":970},"b2":{"y":2195,"x":1005}}}},"1576735":{"name":"Cytochrome oxidase bd (ubiquinol-8: 2 protons)","bigg_id":"CYTBD","reversibility":false,"label_x":4560.4169921875,"label_y":1954.46044921875,"gene_reaction_rule":"(b0978 and b0979) or (b0733 and b0734)","genes":[{"bigg_id":"b0978","name":"cbdA"},{"bigg_id":"b0734","name":"cydB"},{"bigg_id":"b0979","name":"cbdB"},{"bigg_id":"b0733","name":"cydA"}],"metabolites":[{"coefficient":-0.5,"bigg_id":"o2_c"},{"coefficient":1,"bigg_id":"q8_c"},{"coefficient":2,"bigg_id":"h_e"},{"coefficient":-1,"bigg_id":"q8h2_c"},{"coefficient":-2,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"h2o_c"}],"segments":{"58":{"from_node_id":"1576930","to_node_id":"1576928","b1":null,"b2":null},"59":{"from_node_id":"1576928","to_node_id":"1576929","b1":null,"b2":null},"60":{"from_node_id":"1576602","to_node_id":"1576930","b1":{"y":1895.1654052734375,"x":4416.69775390625},"b2":{"y":1900,"x":4595.5}},"61":{"from_node_id":"1576495","to_node_id":"1576930","b1":{"y":1900,"x":4437.906272877015},"b2":{"y":1900,"x":4572.371881863104}},"62":{"from_node_id":"1576542","to_node_id":"1576930","b1":{"y":1890.3310546875,"x":4368.162902237436},"b2":{"y":1900,"x":4581.906341374356}},"63":{"from_node_id":"1576929","to_node_id":"1576539","b1":{"y":1900,"x":4715.894014752448},"b2":{"y":1903.22314453125,"x":4842.38515985191}},"64":{"from_node_id":"1576929","to_node_id":"1576603","b1":{"y":1900,"x":4715.5},"b2":{"y":1900,"x":4775}},"65":{"from_node_id":"1576929","to_node_id":"1576604","b1":{"y":1901.611572265625,"x":4821.203885298877},"b2":{"y":1758.1868896484375,"x":4884.545828600423}}}},"1576736":{"name":"Ribose-5-phosphate isomerase","bigg_id":"RPI","reversibility":true,"label_x":2315,"label_y":1415,"gene_reaction_rule":"b2914 or b4090","genes":[{"bigg_id":"b2914","name":"rpiA"},{"bigg_id":"b4090","name":"rpiB"}],"metabolites":[{"coefficient":1,"bigg_id":"ru5p__D_c"},{"coefficient":-1,"bigg_id":"r5p_c"}],"segments":{"66":{"from_node_id":"1576605","to_node_id":"1576931","b1":{"y":1535.5,"x":2401.9},"b2":{"y":1490,"x":2362}},"67":{"from_node_id":"1576931","to_node_id":"1576493","b1":{"y":1401,"x":2282.5},"b2":{"y":1345,"x":2230}}}},"1576737":{"name":"Malate synthase","bigg_id":"MALS","reversibility":false,"label_x":2921,"label_y":3378,"gene_reaction_rule":"b4014 or b2976","genes":[{"bigg_id":"b2976","name":"glcB"},{"bigg_id":"b4014","name":"aceB"}],"metabolites":[{"coefficient":1,"bigg_id":"coa_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"mal__L_c"},{"coefficient":-1,"bigg_id":"accoa_c"},{"coefficient":-1,"bigg_id":"h2o_c"},{"coefficient":-1,"bigg_id":"glx_c"}],"segments":{"68":{"from_node_id":"1576933","to_node_id":"1576934","b1":null,"b2":null},"69":{"from_node_id":"1576934","to_node_id":"1576932","b1":null,"b2":null},"70":{"from_node_id":"1576532","to_node_id":"1576933","b1":{"y":3508.4324366824735,"x":3086.3665306078124},"b2":{"y":3464.029731004742,"x":3021.7099591823435}},"71":{"from_node_id":"1576606","to_node_id":"1576933","b1":{"y":3478.694083026728,"x":3043.063313881025},"b2":{"y":3455.108224908018,"x":3008.7189941643073}},"72":{"from_node_id":"1576607","to_node_id":"1576933","b1":{"y":3495.7929452157005,"x":3067.961657068476},"b2":{"y":3460.23788356471,"x":3016.1884971205427}},"73":{"from_node_id":"1576932","to_node_id":"1576608","b1":{"y":3330.4075604798036,"x":2827.674768353758},"b2":{"y":3305.691868266011,"x":2791.915894512527}},"74":{"from_node_id":"1576932","to_node_id":"1576609","b1":{"y":3325.297440622825,"x":2820.2814034543},"b2":{"y":3288.6581354094164,"x":2767.2713448476666}},"75":{"from_node_id":"1576932","to_node_id":"1576504","b1":{"y":3318.197058799434,"x":2810.0085106034367},"b2":{"y":3264.9901959981144,"x":2733.0283686781227}}}},"1576739":{"name":"Phosphotransacetylase","bigg_id":"PTAr","reversibility":true,"label_x":1725,"label_y":4075,"gene_reaction_rule":"b2297 or b2458","genes":[{"bigg_id":"b2297","name":"pta"},{"bigg_id":"b2458","name":"eutD"}],"metabolites":[{"coefficient":-1,"bigg_id":"accoa_c"},{"coefficient":1,"bigg_id":"actp_c"},{"coefficient":-1,"bigg_id":"pi_c"},{"coefficient":1,"bigg_id":"coa_c"}],"segments":{"76":{"from_node_id":"1576935","to_node_id":"1576937","b1":null,"b2":null},"77":{"from_node_id":"1576937","to_node_id":"1576936","b1":null,"b2":null},"78":{"from_node_id":"1576514","to_node_id":"1576935","b1":{"y":4005,"x":1715},"b2":{"y":4047,"x":1715}},"79":{"from_node_id":"1576612","to_node_id":"1576935","b1":{"y":4012.7984674554473,"x":1715},"b2":{"y":4049.339540236634,"x":1715}},"80":{"from_node_id":"1576936","to_node_id":"1576613","b1":{"y":4115.5,"x":1715},"b2":{"y":4140,"x":1715}},"81":{"from_node_id":"1576936","to_node_id":"1576614","b1":{"y":4120.660459763366,"x":1715},"b2":{"y":4157.201532544553,"x":1715}}}},"1576741":{"name":"GLNabc","bigg_id":"GLNabc","reversibility":false,"label_x":4535.24462890625,"label_y":4133.49658203125,"gene_reaction_rule":"b0811 and b0810 and b0809","genes":[{"bigg_id":"b0811","name":"glnH"},{"bigg_id":"b0810","name":"glnP"},{"bigg_id":"b0809","name":"glnQ"}],"metabolites":[{"coefficient":-1,"bigg_id":"h2o_c"},{"coefficient":-1,"bigg_id":"atp_c"},{"coefficient":-1,"bigg_id":"gln__L_e"},{"coefficient":1,"bigg_id":"adp_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"pi_c"},{"coefficient":1,"bigg_id":"gln__L_c"}],"segments":{"82":{"from_node_id":"1576940","to_node_id":"1576939","b1":null,"b2":null},"83":{"from_node_id":"1576939","to_node_id":"1576938","b1":null,"b2":null},"84":{"from_node_id":"1576537","to_node_id":"1576940","b1":{"y":4158,"x":4668.5},"b2":{"y":4158,"x":4519.05}},"85":{"from_node_id":"1576615","to_node_id":"1576940","b1":{"y":4158,"x":4519.031242374329},"b2":{"y":4158,"x":4474.209372712298}},"86":{"from_node_id":"1576616","to_node_id":"1576940","b1":{"y":4158,"x":4507.201532544553},"b2":{"y":4158,"x":4470.660459763366}},"87":{"from_node_id":"1576938","to_node_id":"1576578","b1":{"y":4158,"x":4387.893128177527},"b2":{"y":4158,"x":4324.643760591755}},"88":{"from_node_id":"1576938","to_node_id":"1576617","b1":{"y":4158,"x":4390.398170799715},"b2":{"y":4158,"x":4332.993902665717}},"89":{"from_node_id":"1576938","to_node_id":"1576618","b1":{"y":4158,"x":4399.339540236634},"b2":{"y":4158,"x":4362.798467455447}},"90":{"from_node_id":"1576938","to_node_id":"1576619","b1":{"y":4158,"x":4395.790627287702},"b2":{"y":4158,"x":4350.968757625671}}}},"1576742":{"name":"Malic enzyme (NAD)","bigg_id":"ME1","reversibility":false,"label_x":2188.595703125,"label_y":3321.438232421875,"gene_reaction_rule":"b1479","genes":[{"bigg_id":"b1479","name":"maeA"}],"metabolites":[{"coefficient":-1,"bigg_id":"mal__L_c"},{"coefficient":1,"bigg_id":"pyr_c"},{"coefficient":1,"bigg_id":"co2_c"},{"coefficient":-1,"bigg_id":"nad_c"},{"coefficient":1,"bigg_id":"nadh_c"}],"segments":{"91":{"from_node_id":"1576941","to_node_id":"1576942","b1":null,"b2":null},"92":{"from_node_id":"1576942","to_node_id":"1576943","b1":null,"b2":null},"93":{"from_node_id":"1576504","to_node_id":"1576941","b1":{"y":3253.9194505803225,"x":2462.161098839355},"b2":{"y":3307.175835174097,"x":2355.6483296518063}},"94":{"from_node_id":"1576620","to_node_id":"1576941","b1":{"y":3302.9814878277875,"x":2364.0370243444254},"b2":{"y":3321.8944463483363,"x":2326.2111073033275}},"95":{"from_node_id":"1576943","to_node_id":"1576511","b1":{"y":3474.7533185191,"x":2020.4933629618001},"b2":{"y":3870.856276574083,"x":1117.2138384533964}},"96":{"from_node_id":"1576943","to_node_id":"1576621","b1":{"y":3398.949860334106,"x":2172.1002793317884},"b2":{"y":3419.8328677803524,"x":2130.3342644392947}},"97":{"from_node_id":"1576943","to_node_id":"1576622","b1":{"y":3397.5,"x":2175},"b2":{"y":3415,"x":2140}}}},"1576743":{"name":"Glucose 6-phosphate dehydrogenase","bigg_id":"G6PDH2r","reversibility":true,"label_x":1261.46337890625,"label_y":1320.0572509765625,"gene_reaction_rule":"b1852","genes":[{"bigg_id":"b1852","name":"zwf"}],"metabolites":[{"coefficient":-1,"bigg_id":"g6p_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"nadp_c"},{"coefficient":1,"bigg_id":"nadph_c"},{"coefficient":1,"bigg_id":"6pgl_c"}],"segments":{"98":{"from_node_id":"1576946","to_node_id":"1576945","b1":null,"b2":null},"99":{"from_node_id":"1576945","to_node_id":"1576944","b1":null,"b2":null},"100":{"from_node_id":"1576623","to_node_id":"1576946","b1":{"y":1265,"x":1232.3991758303962},"b2":{"y":1265,"x":1270.6197527491188}},"101":{"from_node_id":"1576524","to_node_id":"1576946","b1":{"y":1265,"x":1171},"b2":{"y":1265,"x":1252.2}},"102":{"from_node_id":"1576944","to_node_id":"1576624","b1":{"y":1265,"x":1346.800568173666},"b2":{"y":1265,"x":1393.0018939122203}},"103":{"from_node_id":"1576944","to_node_id":"1576625","b1":{"y":1265,"x":1343.3802472508812},"b2":{"y":1265,"x":1381.6008241696038}},"104":{"from_node_id":"1576944","to_node_id":"1576626","b1":{"y":1265,"x":1354},"b2":{"y":1265,"x":1417}}}},"1576744":{"name":"Acetate exchange","bigg_id":"EX_ac_e","reversibility":false,"label_x":1742.4544677734375,"label_y":4917.06640625,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"ac_e"}],"segments":{"105":{"from_node_id":"1576627","to_node_id":"1576947","b1":{"y":4888.64794921875,"x":1715},"b2":{"y":4890,"x":1715}}}},"1576745":{"name":"Glutaminase","bigg_id":"GLUN","reversibility":false,"label_x":4253.77685546875,"label_y":3866.338134765625,"gene_reaction_rule":"b1812 or b0485 or b1524","genes":[{"bigg_id":"b1524","name":"glsB"},{"bigg_id":"b0485","name":"glsA"},{"bigg_id":"b1812","name":"pabB"}],"metabolites":[{"coefficient":1,"bigg_id":"glu__L_c"},{"coefficient":-1,"bigg_id":"gln__L_c"},{"coefficient":1,"bigg_id":"nh4_c"},{"coefficient":-1,"bigg_id":"h2o_c"}],"segments":{"107":{"from_node_id":"1576950","to_node_id":"1576951","b1":null,"b2":null},"108":{"from_node_id":"1576951","to_node_id":"1576949","b1":null,"b2":null},"109":{"from_node_id":"1576628","to_node_id":"1576950","b1":{"y":3916.003204996513,"x":4247},"b2":{"y":3888.700961498954,"x":4247}},"110":{"from_node_id":"1576578","to_node_id":"1576950","b1":{"y":3985.501152067616,"x":4247},"b2":{"y":3909.550345620285,"x":4247}},"111":{"from_node_id":"1576949","to_node_id":"1576629","b1":{"y":3803.650440537184,"x":4247},"b2":{"y":3777.1681351239463,"x":4247}},"112":{"from_node_id":"1576949","to_node_id":"1576554","b1":{"y":3787.5495901669938,"x":4247},"b2":{"y":3723.4986338899794,"x":4247}}}},"1576746":{"name":"ATP maintenance requirement","bigg_id":"ATPM","reversibility":false,"label_x":4241.11474609375,"label_y":1266.1151123046875,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":1,"bigg_id":"adp_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"atp_c"},{"coefficient":-1,"bigg_id":"h2o_c"},{"coefficient":1,"bigg_id":"pi_c"}],"segments":{"113":{"from_node_id":"1576952","to_node_id":"1576953","b1":null,"b2":null},"114":{"from_node_id":"1576953","to_node_id":"1576954","b1":null,"b2":null},"115":{"from_node_id":"1576534","to_node_id":"1576952","b1":{"y":1120,"x":4215},"b2":{"y":1176,"x":4215}},"116":{"from_node_id":"1576630","to_node_id":"1576952","b1":{"y":1157.5735931288073,"x":4215},"b2":{"y":1187.2720779386423,"x":4215}},"117":{"from_node_id":"1576954","to_node_id":"1576631","b1":{"y":1368.3098334236006,"x":4215},"b2":{"y":1411.0327780786686,"x":4215}},"118":{"from_node_id":"1576954","to_node_id":"1576632","b1":{"y":1361.423659658796,"x":4215},"b2":{"y":1388.0788655293195,"x":4215}},"119":{"from_node_id":"1576954","to_node_id":"1576536","b1":{"y":1374,"x":4215},"b2":{"y":1430,"x":4215}}}},"1576747":{"name":"D-lactate dehydrogenase","bigg_id":"LDH_D","reversibility":true,"label_x":1065,"label_y":4165,"gene_reaction_rule":"b2133 or b1380","genes":[{"bigg_id":"b1380","name":"ldhA"},{"bigg_id":"b2133","name":"dld"}],"metabolites":[{"coefficient":1,"bigg_id":"pyr_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"lac__D_c"},{"coefficient":-1,"bigg_id":"nad_c"},{"coefficient":1,"bigg_id":"nadh_c"}],"segments":{"120":{"from_node_id":"1576956","to_node_id":"1576957","b1":null,"b2":null},"121":{"from_node_id":"1576957","to_node_id":"1576955","b1":null,"b2":null},"122":{"from_node_id":"1576633","to_node_id":"1576956","b1":{"y":4277.201532544553,"x":1055},"b2":{"y":4240.660459763366,"x":1055}},"123":{"from_node_id":"1576584","to_node_id":"1576956","b1":{"y":4285,"x":1055},"b2":{"y":4243,"x":1055}},"124":{"from_node_id":"1576955","to_node_id":"1576634","b1":{"y":4105.790627287702,"x":1055},"b2":{"y":4060.9687576256715,"x":1055}},"125":{"from_node_id":"1576955","to_node_id":"1576511","b1":{"y":4098,"x":1055},"b2":{"y":4035,"x":1055}},"126":{"from_node_id":"1576955","to_node_id":"1576635","b1":{"y":4109.339540236634,"x":1055},"b2":{"y":4072.7984674554473,"x":1055}}}},"1576748":{"name":"Malate dehydrogenase","bigg_id":"MDH","reversibility":true,"label_x":2587,"label_y":3394,"gene_reaction_rule":"b3236","genes":[{"bigg_id":"b3236","name":"mdh"}],"metabolites":[{"coefficient":-1,"bigg_id":"mal__L_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"oaa_c"},{"coefficient":-1,"bigg_id":"nad_c"},{"coefficient":1,"bigg_id":"nadh_c"}],"segments":{"127":{"from_node_id":"1576960","to_node_id":"1576959","b1":null,"b2":null},"128":{"from_node_id":"1576959","to_node_id":"1576958","b1":null,"b2":null},"129":{"from_node_id":"1576504","to_node_id":"1576960","b1":{"y":3264.23165565782,"x":2588.092725741443},"b2":{"y":3317.969496697346,"x":2583.827817722433}},"130":{"from_node_id":"1576636","to_node_id":"1576960","b1":{"y":3294.4959356130375,"x":2585.69079876087},"b2":{"y":3327.0487806839114,"x":2583.107239628261}},"131":{"from_node_id":"1576958","to_node_id":"1576637","b1":{"y":3480.6634859983265,"x":2578.47429780766},"b2":{"y":3538.2116199944217,"x":2579.5809926922}},"132":{"from_node_id":"1576958","to_node_id":"1576638","b1":{"y":3470.7248027204823,"x":2578.2831692830864},"b2":{"y":3505.0826757349405,"x":2578.9438976102874}},"133":{"from_node_id":"1576958","to_node_id":"1576521","b1":{"y":3497.9882185746883,"x":2578.807465741821},"b2":{"y":3595.960728582294,"x":2580.6915524727365}}}},"1576749":{"name":"H2O transport via diffusion","bigg_id":"H2Ot","reversibility":true,"label_x":3267,"label_y":4604,"gene_reaction_rule":"b0875 or s0001","genes":[{"bigg_id":"s0001","name":"None"},{"bigg_id":"b0875","name":"aqpZ"}],"metabolites":[{"coefficient":1,"bigg_id":"h2o_c"},{"coefficient":-1,"bigg_id":"h2o_e"}],"segments":{"134":{"from_node_id":"1576639","to_node_id":"1576961","b1":{"y":4733,"x":3257},"b2":{"y":4684,"x":3257}},"135":{"from_node_id":"1576961","to_node_id":"1576640","b1":{"y":4587,"x":3257},"b2":{"y":4524,"x":3257}}}},"1576750":{"name":"H2O exchange","bigg_id":"EX_h2o_e","reversibility":true,"label_x":3267,"label_y":4914,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"h2o_e"}],"segments":{"136":{"from_node_id":"1576639","to_node_id":"1576962","b1":{"y":4779.5,"x":3257},"b2":{"y":4839,"x":3257}}}},"1576751":{"name":"Transketolase","bigg_id":"TKT1","reversibility":true,"label_x":2185,"label_y":1685,"gene_reaction_rule":"b2935 or b2465","genes":[{"bigg_id":"b2465","name":"tktB"},{"bigg_id":"b2935","name":"tktA"}],"metabolites":[{"coefficient":-1,"bigg_id":"xu5p__D_c"},{"coefficient":-1,"bigg_id":"r5p_c"},{"coefficient":1,"bigg_id":"g3p_c"},{"coefficient":1,"bigg_id":"s7p_c"}],"segments":{"138":{"from_node_id":"1576964","to_node_id":"1576965","b1":null,"b2":null},"139":{"from_node_id":"1576965","to_node_id":"1576966","b1":null,"b2":null},"140":{"from_node_id":"1576605","to_node_id":"1576964","b1":{"y":1557.80791851959,"x":2171.826416015625},"b2":{"y":1605.9896167668144,"x":2175}},"141":{"from_node_id":"1576558","to_node_id":"1576964","b1":{"y":1558.0047151164654,"x":2171.82666015625},"b2":{"y":1607.9527328943145,"x":2175}},"142":{"from_node_id":"1576966","to_node_id":"1576546","b1":{"y":1823.819109636181,"x":2173.413330078125},"b2":{"y":1816.322080948729,"x":2070.2734375}},"143":{"from_node_id":"1576966","to_node_id":"1576545","b1":{"y":1822.232439714306,"x":2175},"b2":{"y":1821.0824569252916,"x":2297.1806640625}}}},"1576752":{"name":"CO2 transporter via diffusion","bigg_id":"CO2t","reversibility":true,"label_x":3631,"label_y":4594,"gene_reaction_rule":"s0001","genes":[{"bigg_id":"s0001","name":"None"}],"metabolites":[{"coefficient":-1,"bigg_id":"co2_e"},{"coefficient":1,"bigg_id":"co2_c"}],"segments":{"144":{"from_node_id":"1576544","to_node_id":"1576967","b1":{"y":4731.5,"x":3621},"b2":{"y":4679,"x":3621}},"145":{"from_node_id":"1576967","to_node_id":"1576641","b1":{"y":4578.5,"x":3621},"b2":{"y":4519,"x":3621}}}},"1576753":{"name":"2-Oxoglutarate exchange","bigg_id":"EX_akg_e","reversibility":false,"label_x":5042,"label_y":3218,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"akg_e"}],"segments":{"146":{"from_node_id":"1576598","to_node_id":"1576969","b1":{"y":3228,"x":4938.5},"b2":{"y":3228,"x":4977}}}},"1576754":{"name":"Phosphoenolpyruvate synthase","bigg_id":"PPS","reversibility":false,"label_x":741.8604125976562,"label_y":3669.90869140625,"gene_reaction_rule":"b1702","genes":[{"bigg_id":"b1702","name":"ppsA"}],"metabolites":[{"coefficient":-1,"bigg_id":"pyr_c"},{"coefficient":-1,"bigg_id":"atp_c"},{"coefficient":1,"bigg_id":"amp_c"},{"coefficient":1,"bigg_id":"pep_c"},{"coefficient":2,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"pi_c"},{"coefficient":-1,"bigg_id":"h2o_c"}],"segments":{"148":{"from_node_id":"1576970","to_node_id":"1576972","b1":null,"b2":null},"149":{"from_node_id":"1576972","to_node_id":"1576971","b1":null,"b2":null},"150":{"from_node_id":"1576642","to_node_id":"1576970","b1":{"y":3860.9016994374947,"x":835},"b2":{"y":3821.7705098312485,"x":835}},"151":{"from_node_id":"1576511","to_node_id":"1576970","b1":{"y":3935.384048104053,"x":835},"b2":{"y":3844.115214431216,"x":835}},"152":{"from_node_id":"1576643","to_node_id":"1576970","b1":{"y":3855,"x":835},"b2":{"y":3820,"x":835}},"153":{"from_node_id":"1576971","to_node_id":"1576517","b1":{"y":3485.059419132917,"x":835},"b2":{"y":3391.8647304430565,"x":835}},"154":{"from_node_id":"1576971","to_node_id":"1576644","b1":{"y":3508.2294901687515,"x":835},"b2":{"y":3469.0983005625053,"x":835}},"155":{"from_node_id":"1576971","to_node_id":"1576645","b1":{"y":3510,"x":835},"b2":{"y":3475,"x":835}},"156":{"from_node_id":"1576971","to_node_id":"1576646","b1":{"y":3503.7867965644036,"x":835},"b2":{"y":3454.289321881345,"x":835}}}},"1576755":{"name":"D-Glucose exchange","bigg_id":"EX_glc__D_e","reversibility":true,"label_x":1082.5206298828125,"label_y":598.4705200195312,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"glc__D_e"}],"segments":{"157":{"from_node_id":"1576647","to_node_id":"1576974","b1":{"y":625.4632568359375,"x":1055.066162109375},"b2":{"y":623.4132690429688,"x":1056.6529541015625}}}},"1576756":{"name":"ETOHt2r","bigg_id":"ETOHt2r","reversibility":true,"label_x":2530.6279296875,"label_y":4611.404296875,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"h_e"},{"coefficient":1,"bigg_id":"etoh_c"},{"coefficient":-1,"bigg_id":"etoh_e"},{"coefficient":1,"bigg_id":"h_c"}],"segments":{"159":{"from_node_id":"1576977","to_node_id":"1576976","b1":null,"b2":null},"160":{"from_node_id":"1576976","to_node_id":"1576975","b1":null,"b2":null},"161":{"from_node_id":"1576648","to_node_id":"1576977","b1":{"y":4782.201532544553,"x":2500},"b2":{"y":4745.660459763366,"x":2500}},"162":{"from_node_id":"1576649","to_node_id":"1576977","b1":{"y":4780,"x":2500},"b2":{"y":4745,"x":2500}},"163":{"from_node_id":"1576975","to_node_id":"1576650","b1":{"y":4414.339540236634,"x":2500},"b2":{"y":4377.798467455447,"x":2500}},"164":{"from_node_id":"1576975","to_node_id":"1576829","b1":{"y":4399.699628715146,"x":2500},"b2":{"y":4328.998762383821,"x":2500}}}},"1576757":{"name":"Phosphoglycerate mutase","bigg_id":"PGM","reversibility":true,"label_x":1065,"label_y":2985,"gene_reaction_rule":"b3612 or b4395 or b0755","genes":[{"bigg_id":"b3612","name":"gpmM"},{"bigg_id":"b4395","name":"ytjC"},{"bigg_id":"b0755","name":"gpmA"}],"metabolites":[{"coefficient":1,"bigg_id":"3pg_c"},{"coefficient":-1,"bigg_id":"2pg_c"}],"segments":{"165":{"from_node_id":"1576522","to_node_id":"1576978","b1":{"y":3105.5,"x":1055},"b2":{"y":3060,"x":1055}},"166":{"from_node_id":"1576978","to_node_id":"1576486","b1":{"y":2977,"x":1055},"b2":{"y":2935,"x":1055}}}},"1576758":{"name":"Ethanol exchange","bigg_id":"EX_etoh_e","reversibility":false,"label_x":2519.520751953125,"label_y":4934.28076171875,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"etoh_e"}],"segments":{"167":{"from_node_id":"1576649","to_node_id":"1576980","b1":{"y":4875.1484375,"x":2500},"b2":{"y":4887.93359375,"x":2500}}}},"1576759":{"name":"Acetate kinase","bigg_id":"ACKr","reversibility":true,"label_x":1737.694091796875,"label_y":4293.5615234375,"gene_reaction_rule":"b3115 or b2296 or b1849","genes":[{"bigg_id":"b2296","name":"ackA"},{"bigg_id":"b3115","name":"tdcD"},{"bigg_id":"b1849","name":"purT"}],"metabolites":[{"coefficient":1,"bigg_id":"adp_c"},{"coefficient":-1,"bigg_id":"ac_c"},{"coefficient":1,"bigg_id":"actp_c"},{"coefficient":-1,"bigg_id":"atp_c"}],"segments":{"169":{"from_node_id":"1576981","to_node_id":"1576982","b1":null,"b2":null},"170":{"from_node_id":"1576982","to_node_id":"1576983","b1":null,"b2":null},"171":{"from_node_id":"1576651","to_node_id":"1576981","b1":{"y":4357.201532544553,"x":1715},"b2":{"y":4320.660459763366,"x":1715}},"172":{"from_node_id":"1576652","to_node_id":"1576981","b1":{"y":4345,"x":1715},"b2":{"y":4317,"x":1715}},"173":{"from_node_id":"1576983","to_node_id":"1576653","b1":{"y":4239.339540236634,"x":1715},"b2":{"y":4202.798467455447,"x":1715}},"174":{"from_node_id":"1576983","to_node_id":"1576613","b1":{"y":4243,"x":1715},"b2":{"y":4215,"x":1715}}}},"1576760":{"name":"Ammonia exchange","bigg_id":"EX_nh4_e","reversibility":true,"label_x":4001,"label_y":4908,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"nh4_e"}],"segments":{"175":{"from_node_id":"1576526","to_node_id":"1576985","b1":{"y":4781.15,"x":3989.3},"b2":{"y":4837.5,"x":3990}}}},"1576761":{"name":"Glutamate synthase (NADPH)","bigg_id":"GLUSy","reversibility":false,"label_x":3984.18701171875,"label_y":3851.553955078125,"gene_reaction_rule":"b3212 and b3213","genes":[{"bigg_id":"b3212","name":"gltB"},{"bigg_id":"b3213","name":"gltD"}],"metabolites":[{"coefficient":2,"bigg_id":"glu__L_c"},{"coefficient":1,"bigg_id":"nadp_c"},{"coefficient":-1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"nadph_c"},{"coefficient":-1,"bigg_id":"gln__L_c"},{"coefficient":-1,"bigg_id":"akg_c"}],"segments":{"177":{"from_node_id":"1576986","to_node_id":"1576988","b1":null,"b2":null},"178":{"from_node_id":"1576988","to_node_id":"1576987","b1":null,"b2":null},"179":{"from_node_id":"1576509","to_node_id":"1576986","b1":{"y":4145.014875810485,"x":3943.568359375},"b2":{"y":4155.746259618145,"x":4119.22314453125}},"180":{"from_node_id":"1576654","to_node_id":"1576986","b1":{"y":3936.7467947664254,"x":4116},"b2":{"y":3902.6240384299276,"x":4116}},"181":{"from_node_id":"1576578","to_node_id":"1576986","b1":{"y":4009.7949095816407,"x":4116},"b2":{"y":3924.538472874492,"x":4116}},"182":{"from_node_id":"1576655","to_node_id":"1576986","b1":{"y":3952.041002490592,"x":4116},"b2":{"y":3907.2123007471773,"x":4116}},"183":{"from_node_id":"1576987","to_node_id":"1576656","b1":{"y":3830.733703350168,"x":4116},"b2":{"y":3790.445677833893,"x":4116}},"184":{"from_node_id":"1576987","to_node_id":"1576554","b1":{"y":3810.0289584024877,"x":4116},"b2":{"y":3721.4298613416263,"x":4116}}}},"1576762":{"name":"Phosphate exchange","bigg_id":"EX_pi_e","reversibility":true,"label_x":2902.694091796875,"label_y":4926.21484375,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"pi_e"}],"segments":{"185":{"from_node_id":"1576594","to_node_id":"1576989","b1":{"y":4896.2666015625,"x":2879.999755859375},"b2":{"y":4909.82177734375,"x":2880}}}},"1576763":{"name":"Fumarate transport via proton symport 2 H ","bigg_id":"FUMt2_2","reversibility":false,"label_x":2851.586669921875,"label_y":845.8676147460938,"gene_reaction_rule":"b3528","genes":[{"bigg_id":"b3528","name":"dctA"}],"metabolites":[{"coefficient":1,"bigg_id":"fum_c"},{"coefficient":2,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"fum_e"},{"coefficient":-2,"bigg_id":"h_e"}],"segments":{"187":{"from_node_id":"1576991","to_node_id":"1576993","b1":null,"b2":null},"188":{"from_node_id":"1576993","to_node_id":"1576992","b1":null,"b2":null},"189":{"from_node_id":"1576657","to_node_id":"1576991","b1":{"y":690,"x":2840},"b2":{"y":718,"x":2840}},"190":{"from_node_id":"1576658","to_node_id":"1576991","b1":{"y":677.7984674554473,"x":2840},"b2":{"y":714.3395402366342,"x":2840}},"191":{"from_node_id":"1576992","to_node_id":"1576659","b1":{"y":995.6604597633658,"x":2840},"b2":{"y":1032.2015325445527,"x":2840}},"192":{"from_node_id":"1576992","to_node_id":"1576503","b1":{"y":1271.0003479379363,"x":2840},"b2":{"y":1950.0011597931211,"x":2840}}}},"1576764":{"name":"Acetate reversible transport via proton symport","bigg_id":"ACt2r","reversibility":true,"label_x":1740.8675537109375,"label_y":4638.470703125,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"h_e"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"ac_e"},{"coefficient":1,"bigg_id":"ac_c"}],"segments":{"193":{"from_node_id":"1576994","to_node_id":"1576995","b1":null,"b2":null},"194":{"from_node_id":"1576995","to_node_id":"1576996","b1":null,"b2":null},"195":{"from_node_id":"1576627","to_node_id":"1576994","b1":{"y":4779.13232421875,"x":1716.5867919921875},"b2":{"y":4760,"x":1715}},"196":{"from_node_id":"1576660","to_node_id":"1576994","b1":{"y":4787.680536450803,"x":1715},"b2":{"y":4760.660459763366,"x":1715}},"197":{"from_node_id":"1576996","to_node_id":"1576652","b1":{"y":4489.49560546875,"x":1715},"b2":{"y":4450.38818359375,"x":1715}},"198":{"from_node_id":"1576996","to_node_id":"1576661","b1":{"y":4485.835145705384,"x":1715},"b2":{"y":4430.253057299197,"x":1719.76025390625}}}},"1576765":{"name":"D-glucose transport via PEP:Pyr PTS","bigg_id":"GLCpts","reversibility":false,"label_x":1074.520263671875,"label_y":929.0499877929688,"gene_reaction_rule":"(b2417 and b1101 and b2415 and b2416) or (b1817 and b1818 and b1819 and b2415 and b2416) or (b2417 and b1621 and b2415 and b2416)","genes":[{"bigg_id":"b1621","name":"malX"},{"bigg_id":"b2416","name":"ptsI"},{"bigg_id":"b1817","name":"manX"},{"bigg_id":"b1101","name":"ptsG"},{"bigg_id":"b1818","name":"manY"},{"bigg_id":"b1819","name":"manZ"},{"bigg_id":"b2415","name":"ptsH"},{"bigg_id":"b2417","name":"crr"}],"metabolites":[{"coefficient":-1,"bigg_id":"pep_c"},{"coefficient":1,"bigg_id":"pyr_c"},{"coefficient":-1,"bigg_id":"glc__D_e"},{"coefficient":1,"bigg_id":"g6p_c"}],"segments":{"199":{"from_node_id":"1576998","to_node_id":"1576997","b1":null,"b2":null},"200":{"from_node_id":"1576997","to_node_id":"1576999","b1":null,"b2":null},"201":{"from_node_id":"1576662","to_node_id":"1576998","b1":{"y":817.6128620109578,"x":962.100078544998},"b2":{"y":830.8607140720374,"x":1056.2982974892807}},"202":{"from_node_id":"1576647","to_node_id":"1576998","b1":{"y":841.218336226978,"x":1054.4691636917553},"b2":{"y":852.0646158583277,"x":1054.6540059434642}},"203":{"from_node_id":"1576999","to_node_id":"1576663","b1":{"y":1155.6497636747395,"x":1056.5867919921875},"b2":{"y":1091.99109457335,"x":1162.89990234375}},"204":{"from_node_id":"1576999","to_node_id":"1576524","b1":{"y":1156.4998046875,"x":1056.5867919921875},"b2":{"y":1159.3526000976562,"x":1055}}}},"1576766":{"name":"Succinate transport out via proton antiport","bigg_id":"SUCCt3","reversibility":false,"label_x":4451.38818359375,"label_y":2819.884765625,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"succ_c"},{"coefficient":1,"bigg_id":"succ_e"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"h_e"}],"segments":{"205":{"from_node_id":"1577002","to_node_id":"1577000","b1":null,"b2":null},"206":{"from_node_id":"1577000","to_node_id":"1577001","b1":null,"b2":null},"207":{"from_node_id":"1576664","to_node_id":"1577002","b1":{"y":2928.186767578125,"x":4395.992900114855},"b2":{"y":2844.388427734375,"x":4392.512762612581}},"208":{"from_node_id":"1576533","to_node_id":"1577002","b1":{"y":2846,"x":3989.9032976766134},"b2":{"y":2846,"x":4388.970989302984}},"209":{"from_node_id":"1577001","to_node_id":"1576531","b1":{"y":2844.388427734375,"x":4830.28303131712},"b2":{"y":2846,"x":4852.764726786234}},"210":{"from_node_id":"1577001","to_node_id":"1576665","b1":{"y":2844.388427734375,"x":4895.4172094976175},"b2":{"y":2757.366943359375,"x":4896.373608481642}}}},"1576768":{"name":"6-phosphogluconolactonase","bigg_id":"PGL","reversibility":false,"label_x":1599.3970947265625,"label_y":1312.1234130859375,"gene_reaction_rule":"b0767","genes":[{"bigg_id":"b0767","name":"pgl"}],"metabolites":[{"coefficient":-1,"bigg_id":"6pgl_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"h2o_c"},{"coefficient":1,"bigg_id":"6pgc_c"}],"segments":{"211":{"from_node_id":"1577005","to_node_id":"1577003","b1":null,"b2":null},"212":{"from_node_id":"1577003","to_node_id":"1577004","b1":null,"b2":null},"213":{"from_node_id":"1576626","to_node_id":"1577005","b1":{"y":1265,"x":1562},"b2":{"y":1265,"x":1600.5}},"214":{"from_node_id":"1576667","to_node_id":"1577005","b1":{"y":1265,"x":1562.3991758303962},"b2":{"y":1265,"x":1600.6197527491188}},"215":{"from_node_id":"1577004","to_node_id":"1576668","b1":{"y":1265,"x":1673.3802472508812},"b2":{"y":1265,"x":1711.6008241696038}},"216":{"from_node_id":"1577004","to_node_id":"1576490","b1":{"y":1265,"x":1682.5},"b2":{"y":1265,"x":1742}}}},"1576769":{"name":"Glyceraldehyde-3-phosphate dehydrogenase","bigg_id":"GAPD","reversibility":true,"label_x":1065,"label_y":2385,"gene_reaction_rule":"b1779","genes":[{"bigg_id":"b1779","name":"gapA"}],"metabolites":[{"coefficient":1,"bigg_id":"13dpg_c"},{"coefficient":-1,"bigg_id":"g3p_c"},{"coefficient":1,"bigg_id":"nadh_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"nad_c"},{"coefficient":-1,"bigg_id":"pi_c"}],"segments":{"217":{"from_node_id":"1577006","to_node_id":"1577008","b1":null,"b2":null},"218":{"from_node_id":"1577008","to_node_id":"1577007","b1":null,"b2":null},"219":{"from_node_id":"1576575","to_node_id":"1577006","b1":{"y":2270,"x":1055},"b2":{"y":2322.5,"x":1055}},"220":{"from_node_id":"1576669","to_node_id":"1577006","b1":{"y":2284.7920271060384,"x":1055},"b2":{"y":2326.9376081318114,"x":1055}},"221":{"from_node_id":"1576670","to_node_id":"1577006","b1":{"y":2297.5658350974745,"x":1055},"b2":{"y":2330.769750529242,"x":1055}},"222":{"from_node_id":"1577007","to_node_id":"1576487","b1":{"y":2454.5,"x":1055},"b2":{"y":2500,"x":1055}},"223":{"from_node_id":"1577007","to_node_id":"1576671","b1":{"y":2453.0623918681886,"x":1055},"b2":{"y":2495.2079728939616,"x":1055}},"224":{"from_node_id":"1577007","to_node_id":"1576672","b1":{"y":2449.230249470758,"x":1055},"b2":{"y":2482.4341649025255,"x":1055}}}},"1576770":{"name":"Fumarate exchange","bigg_id":"EX_fum_e","reversibility":false,"label_x":2915.057373046875,"label_y":529.8175659179688,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"fum_e"}],"segments":{"225":{"from_node_id":"1576657","to_node_id":"1577009","b1":{"y":623,"x":2840},"b2":{"y":560,"x":2840}}}},"1576771":{"name":"Succinate transport via proton symport 2 H ","bigg_id":"SUCCt2_2","reversibility":false,"label_x":4501.95703125,"label_y":2997.661865234375,"gene_reaction_rule":"b3528","genes":[{"bigg_id":"b3528","name":"dctA"}],"metabolites":[{"coefficient":1,"bigg_id":"succ_c"},{"coefficient":-1,"bigg_id":"succ_e"},{"coefficient":2,"bigg_id":"h_c"},{"coefficient":-2,"bigg_id":"h_e"}],"segments":{"227":{"from_node_id":"1577013","to_node_id":"1577011","b1":null,"b2":null},"228":{"from_node_id":"1577011","to_node_id":"1577012","b1":null,"b2":null},"229":{"from_node_id":"1576673","to_node_id":"1577013","b1":{"y":3027,"x":4832.0555127546395},"b2":{"y":3027,"x":4806.816653826392}},"230":{"from_node_id":"1576531","to_node_id":"1577013","b1":{"y":3027,"x":4896.1311639800515},"b2":{"y":3027,"x":4826.039349194016}},"231":{"from_node_id":"1577012","to_node_id":"1576533","b1":{"y":3027,"x":4366.8883209237165},"b2":{"y":3027,"x":3972.294403079054}},"232":{"from_node_id":"1577012","to_node_id":"1576674","b1":{"y":3027,"x":4521},"b2":{"y":3027,"x":4486}}}},"1576772":{"name":"Glutamate dehydrogenase (NADP)","bigg_id":"GLUDy","reversibility":true,"label_x":4025.81298828125,"label_y":3671.95703125,"gene_reaction_rule":"b1761","genes":[{"bigg_id":"b1761","name":"gdhA"}],"metabolites":[{"coefficient":-1,"bigg_id":"glu__L_c"},{"coefficient":-1,"bigg_id":"nadp_c"},{"coefficient":1,"bigg_id":"nh4_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"nadph_c"},{"coefficient":1,"bigg_id":"akg_c"},{"coefficient":-1,"bigg_id":"h2o_c"}],"segments":{"233":{"from_node_id":"1577016","to_node_id":"1577015","b1":null,"b2":null},"234":{"from_node_id":"1577015","to_node_id":"1577014","b1":null,"b2":null},"235":{"from_node_id":"1576675","to_node_id":"1577016","b1":{"y":3632,"x":4170.325901807804},"b2":{"y":3632,"x":4133.6977705423415}},"236":{"from_node_id":"1576554","to_node_id":"1577016","b1":{"y":3632,"x":4183},"b2":{"y":3632,"x":4137.5}},"237":{"from_node_id":"1576676","to_node_id":"1577016","b1":{"y":3632,"x":4156.897300677553},"b2":{"y":3632,"x":4129.669190203266}},"238":{"from_node_id":"1577014","to_node_id":"1576677","b1":{"y":3632,"x":4060.9817744755806},"b2":{"y":3632,"x":4021.2725815852687}},"239":{"from_node_id":"1577014","to_node_id":"1576678","b1":{"y":3632,"x":4054.775659320446},"b2":{"y":3632,"x":4000.5855310681522}},"240":{"from_node_id":"1577014","to_node_id":"1576509","b1":{"y":3632,"x":4028.194352729836},"b2":{"y":3632,"x":3911.98117576612}},"241":{"from_node_id":"1577014","to_node_id":"1576679","b1":{"y":3632,"x":4065.6561756331353},"b2":{"y":3632,"x":4036.853918777118}}}},"1576773":{"name":"ATP synthase (four protons for one ATP)","bigg_id":"ATPS4r","reversibility":true,"label_x":4558.97119140625,"label_y":1122.273193359375,"gene_reaction_rule":"((b3736 and b3737 and b3738) and (b3731 and b3732 and b3733 and b3734 and b3735)) or ((b3736 and b3737 and b3738) and (b3731 and b3732 and b3733 and b3734 and b3735) and b3739)","genes":[{"bigg_id":"b3731","name":"atpC"},{"bigg_id":"b3738","name":"atpB"},{"bigg_id":"b3733","name":"atpG"},{"bigg_id":"b3739","name":"atpI"},{"bigg_id":"b3734","name":"atpA"},{"bigg_id":"b3736","name":"atpF"},{"bigg_id":"b3737","name":"atpE"},{"bigg_id":"b3735","name":"atpH"},{"bigg_id":"b3732","name":"atpD"}],"metabolites":[{"coefficient":-4,"bigg_id":"h_e"},{"coefficient":1,"bigg_id":"atp_c"},{"coefficient":3,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"adp_c"},{"coefficient":-1,"bigg_id":"pi_c"},{"coefficient":1,"bigg_id":"h2o_c"}],"segments":{"242":{"from_node_id":"1577017","to_node_id":"1577019","b1":null,"b2":null},"243":{"from_node_id":"1577019","to_node_id":"1577018","b1":null,"b2":null},"244":{"from_node_id":"1576680","to_node_id":"1577017","b1":{"y":1150,"x":4785},"b2":{"y":1150,"x":4729}},"245":{"from_node_id":"1576681","to_node_id":"1577017","b1":{"y":1332.100830078125,"x":4877.134963734394},"b2":{"y":1150,"x":4746.487950057818}},"246":{"from_node_id":"1576536","to_node_id":"1577017","b1":{"y":1523.8707275390625,"x":4965.504060083706},"b2":{"y":1150,"x":4796.204440681362}},"247":{"from_node_id":"1577018","to_node_id":"1576682","b1":{"y":1148.3885498046875,"x":4558.046875},"b2":{"y":1150,"x":4520}},"248":{"from_node_id":"1577018","to_node_id":"1576683","b1":{"y":1148.388427734375,"x":4575.66162109375},"b2":{"y":1150,"x":4542.7265625}},"249":{"from_node_id":"1577018","to_node_id":"1576534","b1":{"y":1148.3885498046875,"x":4366.332368388376},"b2":{"y":1043.64013671875,"x":4324.116846450839}}}},"1576774":{"name":"Citrate synthase","bigg_id":"CS","reversibility":false,"label_x":2808,"label_y":3876,"gene_reaction_rule":"b0720","genes":[{"bigg_id":"b0720","name":"gltA"}],"metabolites":[{"coefficient":1,"bigg_id":"coa_c"},{"coefficient":-1,"bigg_id":"oaa_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"cit_c"},{"coefficient":-1,"bigg_id":"accoa_c"},{"coefficient":-1,"bigg_id":"h2o_c"}],"segments":{"250":{"from_node_id":"1577020","to_node_id":"1577022","b1":null,"b2":null},"251":{"from_node_id":"1577022","to_node_id":"1577021","b1":null,"b2":null},"252":{"from_node_id":"1576514","to_node_id":"1577020","b1":{"y":3679.773731927161,"x":1727.7705707040077},"b2":{"y":3745.4027250468985,"x":2627.479742988546}},"253":{"from_node_id":"1576684","to_node_id":"1577020","b1":{"y":3791.3182764091857,"x":2693.656876042776},"b2":{"y":3823.2954829227556,"x":2728.8970628128327}},"254":{"from_node_id":"1576521","to_node_id":"1577020","b1":{"y":3789.4902660855073,"x":2691.642334053416},"b2":{"y":3822.7470798256522,"x":2728.292700216025}},"255":{"from_node_id":"1577021","to_node_id":"1576685","b1":{"y":3931.4175627427994,"x":2857.610551099924},"b2":{"y":3962.7252091426644,"x":2898.7018369997472}},"256":{"from_node_id":"1577021","to_node_id":"1576686","b1":{"y":3934.0276661811313,"x":2861.0363118627347},"b2":{"y":3971.425553937104,"x":2910.1210395424487}},"257":{"from_node_id":"1577021","to_node_id":"1576687","b1":{"y":3936.817861413506,"x":2864.698443105226},"b2":{"y":3980.7262047116856,"x":2922.328143684087}}}},"1576775":{"name":"Pyruvate transport in via proton symport","bigg_id":"PYRt2","reversibility":true,"label_x":462.6368408203125,"label_y":3908.02490234375,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":1,"bigg_id":"pyr_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"pyr_e"},{"coefficient":-1,"bigg_id":"h_e"}],"segments":{"258":{"from_node_id":"1577023","to_node_id":"1577025","b1":null,"b2":null},"259":{"from_node_id":"1577025","to_node_id":"1577024","b1":null,"b2":null},"260":{"from_node_id":"1576688","to_node_id":"1577023","b1":{"y":3945,"x":322.7984674554473},"b2":{"y":3945,"x":359.3395402366342}},"261":{"from_node_id":"1576557","to_node_id":"1577023","b1":{"y":3945,"x":325},"b2":{"y":3945,"x":360}},"262":{"from_node_id":"1577024","to_node_id":"1576511","b1":{"y":3945,"x":706.5},"b2":{"y":3945,"x":850}},"263":{"from_node_id":"1577024","to_node_id":"1576689","b1":{"y":3945,"x":660.6604597633658},"b2":{"y":3945,"x":697.2015325445527}}}},"1576776":{"name":"Malic enzyme (NADP)","bigg_id":"ME2","reversibility":false,"label_x":2281.107177734375,"label_y":3432.36328125,"gene_reaction_rule":"b2463","genes":[{"bigg_id":"b2463","name":"maeB"}],"metabolites":[{"coefficient":1,"bigg_id":"pyr_c"},{"coefficient":-1,"bigg_id":"mal__L_c"},{"coefficient":1,"bigg_id":"co2_c"},{"coefficient":-1,"bigg_id":"nadp_c"},{"coefficient":1,"bigg_id":"nadph_c"}],"segments":{"264":{"from_node_id":"1577028","to_node_id":"1577026","b1":null,"b2":null},"265":{"from_node_id":"1577026","to_node_id":"1577027","b1":null,"b2":null},"266":{"from_node_id":"1576690","to_node_id":"1577028","b1":{"y":3329.0232535031614,"x":2361.6279108280646},"b2":{"y":3350.7069760509485,"x":2325.4883732484195}},"267":{"from_node_id":"1576504","to_node_id":"1577028","b1":{"y":3269.069152001936,"x":2461.551413330107},"b2":{"y":3332.720745600581,"x":2355.4654239990323}},"268":{"from_node_id":"1577027","to_node_id":"1576691","b1":{"y":3417.2249567472754,"x":2205.550086505449},"b2":{"y":3434.0831891575845,"x":2171.8336216848306}},"269":{"from_node_id":"1577027","to_node_id":"1576511","b1":{"y":3495.997238327751,"x":2048.005523344498},"b2":{"y":3895.002675936253,"x":1164.309223322806}},"270":{"from_node_id":"1577027","to_node_id":"1576692","b1":{"y":3418.8232647019117,"x":2202.3534705961765},"b2":{"y":3439.4108823397055,"x":2161.178235320589}}}},"1576777":{"name":"Formate exchange","bigg_id":"EX_for_e","reversibility":false,"label_x":1476.3470458984375,"label_y":4913.4130859375,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"for_e"}],"segments":{"271":{"from_node_id":"1576666","to_node_id":"1577030","b1":{"y":4885.96044921875,"x":1461.5867919921875},"b2":{"y":4884.95458984375,"x":1460}}}},"1577490":{"name":"Acetaldehyde dehydrogenase (acetylating)","bigg_id":"ACALD","reversibility":true,"label_x":1939.0750732421875,"label_y":3998.470458984375,"gene_reaction_rule":"b0351 or b1241","genes":[{"bigg_id":"b1241","name":"adhE"},{"bigg_id":"b0351","name":"mhpF"}],"metabolites":[{"coefficient":1,"bigg_id":"nadh_c"},{"coefficient":-1,"bigg_id":"coa_c"},{"coefficient":-1,"bigg_id":"acald_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"nad_c"},{"coefficient":1,"bigg_id":"accoa_c"}],"segments":{"273":{"from_node_id":"1577031","to_node_id":"1577032","b1":null,"b2":null},"274":{"from_node_id":"1577032","to_node_id":"1577033","b1":null,"b2":null},"275":{"from_node_id":"1576817","to_node_id":"1577031","b1":{"y":3945,"x":2125},"b2":{"y":3945,"x":2065.5}},"276":{"from_node_id":"1576825","to_node_id":"1577031","b1":{"y":3945,"x":2101.8970920157},"b2":{"y":3945,"x":2058.56912760471}},"277":{"from_node_id":"1576828","to_node_id":"1577031","b1":{"y":3945,"x":2085.0693909433},"b2":{"y":3945,"x":2053.52081728299}},"278":{"from_node_id":"1577033","to_node_id":"1576514","b1":{"y":3945,"x":1940.25},"b2":{"y":3945,"x":1847.5}},"279":{"from_node_id":"1577033","to_node_id":"1576832","b1":{"y":3945,"x":1966.47918271701},"b2":{"y":3945,"x":1934.9306090567002}},"280":{"from_node_id":"1577033","to_node_id":"1576812","b1":{"y":3945,"x":1961.4308723952902},"b2":{"y":3945,"x":1918.1029079843004}}}},"1577497":{"name":"Acetaldehyde reversible transport","bigg_id":"ACALDt","reversibility":true,"label_x":2248.561767578125,"label_y":4579.041015625,"gene_reaction_rule":"s0001","genes":[{"bigg_id":"s0001","name":"None"}],"metabolites":[{"coefficient":1,"bigg_id":"acald_c"},{"coefficient":-1,"bigg_id":"acald_e"}],"segments":{"281":{"from_node_id":"1576815","to_node_id":"1577034","b1":{"y":4796.55283203125,"x":2210},"b2":{"y":4707,"x":2210}},"282":{"from_node_id":"1577034","to_node_id":"1576817","b1":{"y":4476.25,"x":2210},"b2":{"y":4257.5,"x":2210}}}},"1577498":{"name":"Acetaldehyde exchange","bigg_id":"EX_acald_e","reversibility":false,"label_x":2227.346923828125,"label_y":4922.892578125,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"acald_e"}],"segments":{"283":{"from_node_id":"1576815","to_node_id":"1577035","b1":{"y":4889.1484375,"x":2210.15},"b2":{"y":4894,"x":2210.5}}}},"1577507":{"name":"Alcohol dehydrogenase (ethanol)","bigg_id":"ALCD2x","reversibility":true,"label_x":2356.4794921875,"label_y":4047.4384765625,"gene_reaction_rule":"b0356 or b1478 or b1241","genes":[{"bigg_id":"b1241","name":"adhE"},{"bigg_id":"b0356","name":"frmA"},{"bigg_id":"b1478","name":"adhP"}],"metabolites":[{"coefficient":1,"bigg_id":"acald_c"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"nad_c"},{"coefficient":1,"bigg_id":"nadh_c"},{"coefficient":-1,"bigg_id":"etoh_c"}],"segments":{"2":{"from_node_id":"1577041","to_node_id":"1577042","b1":null,"b2":null},"3":{"from_node_id":"1577042","to_node_id":"1577043","b1":null,"b2":null},"4":{"from_node_id":"1576829","to_node_id":"1577041","b1":{"y":4162.240740184523,"x":2437.6865073405606},"b2":{"y":4118.6722220553565,"x":2391.0059522021684}},"5":{"from_node_id":"1576822","to_node_id":"1577041","b1":{"y":4139.7065841719395,"x":2413.5427687556494},"b2":{"y":4111.911975251582,"x":2383.7628306266947}},"6":{"from_node_id":"1577043","to_node_id":"1576817","b1":{"y":4050.989239830398,"x":2323.3232905083714},"b2":{"y":4004.2974661013272,"x":2279.744301694572}},"7":{"from_node_id":"1577043","to_node_id":"1576813","b1":{"y":4059.6140048832744,"x":2331.3730712243896},"b2":{"y":4033.046682944248,"x":2306.576904081298}},"8":{"from_node_id":"1577043","to_node_id":"1576824","b1":{"y":4056.0538526083565,"x":2328.0502624344663},"b2":{"y":4021.1795086945217,"x":2295.5008747815536}}}},"1577514":{"name":"Formate transport in via proton symport","bigg_id":"FORt2","reversibility":false,"label_x":1255.7530517578125,"label_y":4574.13232421875,"gene_reaction_rule":"b0904 or b2492","genes":[{"bigg_id":"b2492","name":"focB"},{"bigg_id":"b0904","name":"focA"}],"metabolites":[{"coefficient":-1,"bigg_id":"for_e"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"for_c"},{"coefficient":-1,"bigg_id":"h_e"}],"segments":{"9":{"from_node_id":"1577044","to_node_id":"1577045","b1":null,"b2":null},"10":{"from_node_id":"1577045","to_node_id":"1577046","b1":null,"b2":null},"11":{"from_node_id":"1576666","to_node_id":"1577044","b1":{"y":4827.353507999329,"x":1360},"b2":{"y":4749.209372712298,"x":1360}},"12":{"from_node_id":"1576833","to_node_id":"1577044","b1":{"y":4779.244289008981,"x":1360},"b2":{"y":4744.773286702694,"x":1360}},"13":{"from_node_id":"1577046","to_node_id":"1576590","b1":{"y":4411.784344889025,"x":1360},"b2":{"y":4275.94781629675,"x":1360}},"14":{"from_node_id":"1577046","to_node_id":"1576811","b1":{"y":4455.769750529243,"x":1360},"b2":{"y":4422.5658350974745,"x":1360}}}},"1577518":{"name":"Formate transport via diffusion","bigg_id":"FORti","reversibility":false,"label_x":1479.5206298828125,"label_y":4509.27197265625,"gene_reaction_rule":"b0904 or b2492","genes":[{"bigg_id":"b2492","name":"focB"},{"bigg_id":"b0904","name":"focA"}],"metabolites":[{"coefficient":1,"bigg_id":"for_e"},{"coefficient":-1,"bigg_id":"for_c"}],"segments":{"15":{"from_node_id":"1576590","to_node_id":"1577047","b1":{"y":4145.55,"x":1460},"b2":{"y":4263.5,"x":1460}},"16":{"from_node_id":"1577047","to_node_id":"1576666","b1":{"y":4488.7,"x":1460},"b2":{"y":4654.322265625,"x":1460}}}},"1577520":{"name":"Fumarate reductase","bigg_id":"FRD7","reversibility":false,"label_x":3078.744384765625,"label_y":2572.54541015625,"gene_reaction_rule":"b4151 and b4152 and b4153 and b4154","genes":[{"bigg_id":"b4152","name":"frdC"},{"bigg_id":"b4151","name":"frdD"},{"bigg_id":"b4154","name":"frdA"},{"bigg_id":"b4153","name":"frdB"}],"metabolites":[{"coefficient":1,"bigg_id":"succ_c"},{"coefficient":-1,"bigg_id":"fum_c"},{"coefficient":1,"bigg_id":"q8_c"},{"coefficient":-1,"bigg_id":"q8h2_c"}],"segments":{"17":{"from_node_id":"1577048","to_node_id":"1577049","b1":null,"b2":null},"18":{"from_node_id":"1577049","to_node_id":"1577050","b1":null,"b2":null},"19":{"from_node_id":"1576503","to_node_id":"1577048","b1":{"y":2600,"x":2880.896383759611},"b2":{"y":2600,"x":3020.2689151278832}},"20":{"from_node_id":"1576830","to_node_id":"1577048","b1":{"y":2600,"x":3003.842268941361},"b2":{"y":2600,"x":3057.152680682408}},"21":{"from_node_id":"1577050","to_node_id":"1576814","b1":{"y":2600,"x":3162.14723459035},"b2":{"y":2600,"x":3213.824115301167}},"22":{"from_node_id":"1577050","to_node_id":"1576533","b1":{"y":2600,"x":3198.034494053106},"b2":{"y":2600,"x":3333.4483135103533}}}},"1577524":{"name":"Fructose transport via PEPPyr PTS f6p generating ","bigg_id":"FRUpts2","reversibility":false,"label_x":456.41497802734375,"label_y":1327.7852783203125,"gene_reaction_rule":"b1817 and b1818 and b1819 and b2415 and b2416","genes":[{"bigg_id":"b1819","name":"manZ"},{"bigg_id":"b1817","name":"manX"},{"bigg_id":"b2415","name":"ptsH"},{"bigg_id":"b2416","name":"ptsI"},{"bigg_id":"b1818","name":"manY"}],"metabolites":[{"coefficient":-1,"bigg_id":"pep_c"},{"coefficient":1,"bigg_id":"f6p_c"},{"coefficient":-1,"bigg_id":"fru_e"},{"coefficient":1,"bigg_id":"pyr_c"}],"segments":{"23":{"from_node_id":"1577051","to_node_id":"1577052","b1":null,"b2":null},"24":{"from_node_id":"1577052","to_node_id":"1577053","b1":null,"b2":null},"25":{"from_node_id":"1576826","to_node_id":"1577051","b1":{"y":1360,"x":465},"b2":{"y":1361.5867919921875,"x":526.550048828125}},"26":{"from_node_id":"1576819","to_node_id":"1577051","b1":{"y":1452.0322265625,"x":400.008457770101},"b2":{"y":1360,"x":396.1378949970459}},"27":{"from_node_id":"1577053","to_node_id":"1576525","b1":{"y":1363.1734619140625,"x":860.370260215258},"b2":{"y":1361.586669921875,"x":917.1118252292455}},"28":{"from_node_id":"1577053","to_node_id":"1576821","b1":{"y":1364.76025390625,"x":861.4990623462952},"b2":{"y":1240.992919921875,"x":861.106575008484}}}},"1577529":{"name":"D-Fructose exchange","bigg_id":"EX_fru_e","reversibility":false,"label_x":125.35597229003906,"label_y":1321.438232421875,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"fru_e"}],"segments":{"29":{"from_node_id":"1576826","to_node_id":"1577054","b1":{"y":1360,"x":282.3},"b2":{"y":1360,"x":241}}}},"1577532":{"name":"Malate transport via proton symport 2 H ","bigg_id":"MALt2_2","reversibility":false,"label_x":2623.173583984375,"label_y":844.3793334960938,"gene_reaction_rule":"b3528","genes":[{"bigg_id":"b3528","name":"dctA"}],"metabolites":[{"coefficient":1,"bigg_id":"mal__L_c"},{"coefficient":2,"bigg_id":"h_c"},{"coefficient":-1,"bigg_id":"mal__L_e"},{"coefficient":-2,"bigg_id":"h_e"}],"segments":{"31":{"from_node_id":"1577056","to_node_id":"1577057","b1":null,"b2":null},"32":{"from_node_id":"1577057","to_node_id":"1577058","b1":null,"b2":null},"33":{"from_node_id":"1576831","to_node_id":"1577056","b1":{"y":682.8586789776543,"x":2610},"b2":{"y":720.0576036932963,"x":2610}},"34":{"from_node_id":"1576816","to_node_id":"1577056","b1":{"y":693,"x":2610},"b2":{"y":723.1,"x":2610}},"35":{"from_node_id":"1577058","to_node_id":"1576810","b1":{"y":995.6604597633658,"x":2610},"b2":{"y":1032.2015325445527,"x":2610}},"36":{"from_node_id":"1577058","to_node_id":"1576504","b1":{"y":1311.8041025966977,"x":2610},"b2":{"y":2086.013675322326,"x":2610}}}},"1577537":{"name":"L-Malate exchange","bigg_id":"EX_mal__L_e","reversibility":false,"label_x":2356.597412109375,"label_y":513.949951171875,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":-1,"bigg_id":"mal__L_e"}],"segments":{"37":{"from_node_id":"1576816","to_node_id":"1577059","b1":{"y":623,"x":2610},"b2":{"y":560,"x":2610}}}},"1577540":{"name":"NADH dehydrogenase (ubiquinone-8 & 3 protons)","bigg_id":"NADH16","reversibility":false,"label_x":4589.75537109375,"label_y":2624.46044921875,"gene_reaction_rule":"b2276 and b2277 and b2278 and b2279 and b2280 and b2281 and b2282 and b2283 and b2284 and b2285 and b2286 and b2287 and b2288","genes":[{"bigg_id":"b2284","name":"nuoF"},{"bigg_id":"b2279","name":"nuoK"},{"bigg_id":"b2287","name":"nuoB"},{"bigg_id":"b2286","name":"nuoC"},{"bigg_id":"b2288","name":"nuoA"},{"bigg_id":"b2283","name":"nuoG"},{"bigg_id":"b2277","name":"nuoM"},{"bigg_id":"b2281","name":"nuoI"},{"bigg_id":"b2280","name":"nuoJ"},{"bigg_id":"b2276","name":"nuoN"},{"bigg_id":"b2282","name":"nuoH"},{"bigg_id":"b2278","name":"nuoL"},{"bigg_id":"b2285","name":"nuoE"}],"metabolites":[{"coefficient":3,"bigg_id":"h_e"},{"coefficient":-1,"bigg_id":"q8_c"},{"coefficient":-1,"bigg_id":"nadh_c"},{"coefficient":1,"bigg_id":"q8h2_c"},{"coefficient":-4,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"nad_c"}],"segments":{"39":{"from_node_id":"1577061","to_node_id":"1577062","b1":null,"b2":null},"40":{"from_node_id":"1577062","to_node_id":"1577063","b1":null,"b2":null},"41":{"from_node_id":"1576820","to_node_id":"1577061","b1":{"y":2570,"x":4470},"b2":{"y":2570,"x":4582}},"42":{"from_node_id":"1576827","to_node_id":"1577061","b1":{"y":2567.302001953125,"x":4458.799047943291},"b2":{"y":2570,"x":4595.729021023612}},"43":{"from_node_id":"1576539","to_node_id":"1577061","b1":{"y":2375.007080078125,"x":4706.342147363639},"b2":{"y":2570,"x":4542.513923505967}},"44":{"from_node_id":"1577063","to_node_id":"1576808","b1":{"y":2568.388427734375,"x":4766.45361328125},"b2":{"y":2570,"x":4780}},"45":{"from_node_id":"1577063","to_node_id":"1576809","b1":{"y":2570.000244140625,"x":4798.6355690569735},"b2":{"y":2655.409912109375,"x":4928.099683314913}},"46":{"from_node_id":"1577063","to_node_id":"1576542","b1":{"y":2571.611572265625,"x":4800.053949169604},"b2":{"y":2507.151123046875,"x":4630.938294107013}}}},"1577545":{"name":"Succinate dehydrogenase (irreversible)","bigg_id":"SUCDi","reversibility":false,"label_x":3108.851318359375,"label_y":2862.949951171875,"gene_reaction_rule":"b0721 and b0722 and b0723 and b0724","genes":[{"bigg_id":"b0724","name":"sdhB"},{"bigg_id":"b0721","name":"sdhC"},{"bigg_id":"b0722","name":"sdhD"},{"bigg_id":"b0723","name":"sdhA"}],"metabolites":[{"coefficient":-1,"bigg_id":"succ_c"},{"coefficient":1,"bigg_id":"fum_c"},{"coefficient":-1,"bigg_id":"q8_c"},{"coefficient":1,"bigg_id":"q8h2_c"}],"segments":{"47":{"from_node_id":"1577064","to_node_id":"1577065","b1":null,"b2":null},"48":{"from_node_id":"1577065","to_node_id":"1577066","b1":null,"b2":null},"49":{"from_node_id":"1576814","to_node_id":"1577064","b1":{"y":2815.1969315980286,"x":3225.9782442502737},"b2":{"y":2816.4590794794085,"x":3193.7934732750823}},"50":{"from_node_id":"1576533","to_node_id":"1577064","b1":{"y":2812.1967701205886,"x":3302.482361924995},"b2":{"y":2815.5590310361767,"x":3216.7447085774984}},"51":{"from_node_id":"1577066","to_node_id":"1576503","b1":{"y":2831.162537495866,"x":3040.3872268158307},"b2":{"y":2843.2084583195547,"x":2952.624089386102}},"52":{"from_node_id":"1577066","to_node_id":"1576830","b1":{"y":2828.1157896960085,"x":3062.5849607862237},"b2":{"y":2833.0526323200284,"x":3026.6165359540787}}}},"1577546":{"name":"D lactate transport via proton symport","bigg_id":"D_LACt2","reversibility":true,"label_x":1078.65283203125,"label_y":4609.72607421875,"gene_reaction_rule":"b2975 or b3603","genes":[{"bigg_id":"b3603","name":"lldP"},{"bigg_id":"b2975","name":"glcA"}],"metabolites":[{"coefficient":-1,"bigg_id":"lac__D_e"},{"coefficient":1,"bigg_id":"h_c"},{"coefficient":1,"bigg_id":"lac__D_c"},{"coefficient":-1,"bigg_id":"h_e"}],"segments":{"476":{"from_node_id":"1577067","to_node_id":"1577068","b1":null,"b2":null},"477":{"from_node_id":"1577069","to_node_id":"1577068","b1":null,"b2":null},"478":{"from_node_id":"1577067","to_node_id":"1576556","b1":{"y":4692.98193359375,"x":1055},"b2":{"y":4736.89501953125,"x":1054.9998779296875}},"479":{"from_node_id":"1577067","to_node_id":"1577071","b1":{"y":4696.98193359375,"x":1055},"b2":{"y":4715.98193359375,"x":1076}},"480":{"from_node_id":"1577069","to_node_id":"1576584","b1":{"y":4474.7353515625,"x":1053.4132080078125},"b2":{"y":4413.36767578125,"x":1055}},"481":{"from_node_id":"1577069","to_node_id":"1577072","b1":{"y":4470.7353515625,"x":1053.4132080078125},"b2":{"y":4451.7353515625,"x":1074.4132080078125}}}},"1577547":{"name":"Biomass Objective Function with GAM","bigg_id":"BIOMASS_Ecoli_core_w_GAM","reversibility":false,"label_x":5392.94580078125,"label_y":4746.6962890625,"gene_reaction_rule":"","genes":[],"metabolites":[{"coefficient":3.7478,"bigg_id":"coa_c"},{"coefficient":-0.8977,"bigg_id":"r5p_c"},{"coefficient":-1.496,"bigg_id":"3pg_c"},{"coefficient":-0.361,"bigg_id":"e4p_c"},{"coefficient":-0.2557,"bigg_id":"gln__L_c"},{"coefficient":3.547,"bigg_id":"nadh_c"},{"coefficient":-2.8328,"bigg_id":"pyr_c"},{"coefficient":-0.0709,"bigg_id":"f6p_c"},{"coefficient":-13.0279,"bigg_id":"nadph_c"},{"coefficient":-3.7478,"bigg_id":"accoa_c"},{"coefficient":-1.7867,"bigg_id":"oaa_c"},{"coefficient":-0.129,"bigg_id":"g3p_c"},{"coefficient":-3.547,"bigg_id":"nad_c"},{"coefficient":59.81,"bigg_id":"pi_c"},{"coefficient":-0.205,"bigg_id":"g6p_c"},{"coefficient":4.1182,"bigg_id":"akg_c"},{"coefficient":-0.5191,"bigg_id":"pep_c"},{"coefficient":-4.9414,"bigg_id":"glu__L_c"},{"coefficient":-59.81,"bigg_id":"atp_c"},{"coefficient":59.81,"bigg_id":"adp_c"},{"coefficient":59.81,"bigg_id":"h_c"},{"coefficient":-59.81,"bigg_id":"h2o_c"},{"coefficient":13.0279,"bigg_id":"nadp_c"}],"segments":{"482":{"from_node_id":"1577074","to_node_id":"1577075","b1":null,"b2":null},"483":{"from_node_id":"1577076","to_node_id":"1577075","b1":null,"b2":null},"484":{"from_node_id":"1577074","to_node_id":"1577073","b1":{"y":4685.48193359375,"x":5334.0517578125},"b2":{"y":4573.30322265625,"x":5455.328125}},"485":{"from_node_id":"1577076","to_node_id":"1577077","b1":{"y":4793.48193359375,"x":5334.0517578125},"b2":{"y":4926.6220703125,"x":5391.197265625}},"486":{"from_node_id":"1577074","to_node_id":"1577078","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4630.19921875,"x":5427.28515625}},"487":{"from_node_id":"1577074","to_node_id":"1577079","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4516.16943359375,"x":5423.4208984375}},"488":{"from_node_id":"1577074","to_node_id":"1577080","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4453.01611328125,"x":5350.98828125}},"489":{"from_node_id":"1577076","to_node_id":"1577081","b1":{"y":4793.48193359375,"x":5334.0517578125},"b2":{"y":5001.37158203125,"x":5337.27587890625}},"490":{"from_node_id":"1577074","to_node_id":"1577082","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4413.09912109375,"x":5307.541015625}},"491":{"from_node_id":"1577074","to_node_id":"1577083","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4523.05615234375,"x":5316.9716796875}},"492":{"from_node_id":"1577074","to_node_id":"1577084","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4533.61865234375,"x":5258.0712890625}},"493":{"from_node_id":"1577074","to_node_id":"1577085","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4544.18115234375,"x":5197.05859375}},"494":{"from_node_id":"1577074","to_node_id":"1577086","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4564.25048828125,"x":5140.27099609375}},"495":{"from_node_id":"1577076","to_node_id":"1577087","b1":{"y":4793.48193359375,"x":5334.0517578125},"b2":{"y":4938.26416015625,"x":5273.55517578125}},"496":{"from_node_id":"1577074","to_node_id":"1577088","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4579.03759765625,"x":5068.69580078125}},"497":{"from_node_id":"1577074","to_node_id":"1577089","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4594.88134765625,"x":5023.52734375}},"498":{"from_node_id":"1577076","to_node_id":"1577090","b1":{"y":4793.48193359375,"x":5334.0517578125},"b2":{"y":4899.2412109375,"x":5215.0458984375}},"499":{"from_node_id":"1577076","to_node_id":"1577091","b1":{"y":4789.48193359375,"x":5334.0517578125},"b2":{"y":4977.43115234375,"x":5353.5947265625}},"500":{"from_node_id":"1577074","to_node_id":"1577092","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4611.78173828125,"x":4962.51416015625}},"501":{"from_node_id":"1577074","to_node_id":"1577093","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4637.1318359375,"x":4907.83935546875}},"502":{"from_node_id":"1577074","to_node_id":"1577094","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4664.59423828125,"x":4851.0517578125}},"503":{"from_node_id":"1577074","to_node_id":"1577095","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4685.7197265625,"x":4807.9951171875}},"504":{"from_node_id":"1577076","to_node_id":"1577096","b1":{"y":4793.48193359375,"x":5334.0517578125},"b2":{"y":4868.333984375,"x":5114.79541015625}},"505":{"from_node_id":"1577074","to_node_id":"1577097","b1":{"y":4681.48193359375,"x":5334.0517578125},"b2":{"y":4717.4072265625,"x":4780.78271484375}},"506":{"from_node_id":"1577076","to_node_id":"1577098","b1":{"y":4793.48193359375,"x":5334.0517578125},"b2":{"y":4820.185546875,"x":5099.533203125}}}},"1577548":{"name":"Aconitase (half-reaction A, Citrate hydro-lyase)","bigg_id":"ACONTa","reversibility":true,"label_x":2982.991259697708,"label_y":4088.6436288689247,"gene_reaction_rule":"b0118 or b1276","genes":[{"bigg_id":"b0118","name":"acnB"},{"bigg_id":"b1276","name":"acnA"}],"metabolites":[{"coefficient":-1,"bigg_id":"cit_c"},{"coefficient":1,"bigg_id":"h2o_c"},{"coefficient":1,"bigg_id":"acon_C_c"}],"segments":{"507":{"from_node_id":"1577099","to_node_id":"1577100","b1":null,"b2":null},"508":{"from_node_id":"1577101","to_node_id":"1577100","b1":null,"b2":null},"509":{"from_node_id":"1577101","to_node_id":"1577102","b1":{"y":4044.558477078102,"x":3125.4142208172407},"b2":{"y":3993.9154608910203,"x":3112.4765239553985}},"510":{"from_node_id":"1577101","to_node_id":"1577103","b1":{"y":4044.2013827305695,"x":3108.646756937047},"b2":{"y":4045.94073519232,"x":3126.6630443215304}},"511":{"from_node_id":"1577099","to_node_id":"1576685","b1":{"y":4012.0956406322803,"x":3025.7810749583687},"b2":{"y":4010.3555557486548,"x":3025.1432055426353}}}},"1577549":{"name":"Aconitase (half-reaction B, Isocitrate hydro-lyase)","bigg_id":"ACONTb","reversibility":true,"label_x":3291.833217745038,"label_y":4081.35343547726,"gene_reaction_rule":"b0118 or b1276","genes":[{"bigg_id":"b1276","name":"acnA"},{"bigg_id":"b0118","name":"acnB"}],"metabolites":[{"coefficient":1,"bigg_id":"icit_c"},{"coefficient":-1,"bigg_id":"h2o_c"},{"coefficient":-1,"bigg_id":"acon_C_c"}],"segments":{"512":{"from_node_id":"1577104","to_node_id":"1577105","b1":null,"b2":null},"513":{"from_node_id":"1577106","to_node_id":"1577105","b1":null,"b2":null},"514":{"from_node_id":"1577104","to_node_id":"1577102","b1":{"y":4044.360816430351,"x":3261.354277099013},"b2":{"y":3991.5491179659602,"x":3266.0226278968735}},"515":{"from_node_id":"1577106","to_node_id":"1576505","b1":{"y":4014.8024620364417,"x":3344.105236291347},"b2":{"y":4013.1918298584474,"x":3345.4226198631072}},"516":{"from_node_id":"1577104","to_node_id":"1577103","b1":{"y":4046.056264386829,"x":3262.862957011229},"b2":{"y":4046.222560627323,"x":3260.813883986344}}}}},"nodes":{"1576485":{"node_type":"metabolite","x":1145,"y":2805,"bigg_id":"atp_c","name":"ATP","label_x":1165,"label_y":2805,"node_is_primary":false},"1576486":{"node_type":"metabolite","x":1055,"y":2875,"bigg_id":"3pg_c","name":"3-Phospho-D-glycerate","label_x":1085,"label_y":2875,"node_is_primary":true},"1576487":{"node_type":"metabolite","x":1055,"y":2565,"bigg_id":"13dpg_c","name":"3-Phospho-D-glyceroyl phosphate","label_x":1085,"label_y":2565,"node_is_primary":true},"1576488":{"node_type":"metabolite","x":1145,"y":2635,"bigg_id":"adp_c","name":"ADP","label_x":1165,"label_y":2635,"node_is_primary":false},"1576489":{"node_type":"metabolite","x":1907,"y":1165,"bigg_id":"nadp_c","name":"Nicotinamide adenine dinucleotide phosphate","label_x":1907,"label_y":1145,"node_is_primary":false},"1576490":{"node_type":"metabolite","x":1827,"y":1265,"bigg_id":"6pgc_c","name":"6-Phospho-D-gluconate","label_x":1800.0250244140625,"label_y":1235,"node_is_primary":true},"1576491":{"node_type":"metabolite","x":2007,"y":1165,"bigg_id":"co2_c","name":"CO2","label_x":2007,"label_y":1145,"node_is_primary":false},"1576492":{"node_type":"metabolite","x":2057,"y":1165,"bigg_id":"nadph_c","name":"Nicotinamide adenine dinucleotide phosphate - reduced","label_x":2080,"label_y":1140,"node_is_primary":false},"1576493":{"node_type":"metabolite","x":2155,"y":1265,"bigg_id":"ru5p__D_c","name":"D-Ribulose 5-phosphate","label_x":2155,"label_y":1235,"node_is_primary":true},"1576494":{"node_type":"metabolite","x":4850,"y":1660,"bigg_id":"o2_e","name":"O2","label_x":4840.3310546875,"label_y":1702.89208984375,"node_is_primary":true},"1576495":{"node_type":"metabolite","x":4330,"y":1660,"bigg_id":"o2_c","name":"O2","label_x":4259.09326171875,"label_y":1677.4388427734375,"node_is_primary":true},"1576496":{"node_type":"metabolite","x":3330,"y":1270,"bigg_id":"nadp_c","name":"Nicotinamide adenine dinucleotide phosphate","label_x":3330,"label_y":1310,"node_is_primary":true},"1576497":{"node_type":"metabolite","x":3420,"y":1120,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":3450,"label_y":1150,"node_is_primary":true},"1576498":{"node_type":"metabolite","x":3510,"y":650,"bigg_id":"h_e","name":"H+","label_x":3529.338134765625,"label_y":639.6690673828125,"node_is_primary":false},"1576499":{"node_type":"metabolite","x":3510,"y":1080.287841796875,"bigg_id":"h_c","name":"H+","label_x":3522.892333984375,"label_y":1099.0072021484375,"node_is_primary":false},"1576500":{"node_type":"metabolite","x":3740,"y":1270,"bigg_id":"nadph_c","name":"Nicotinamide adenine dinucleotide phosphate - reduced","label_x":3740,"label_y":1310,"node_is_primary":true},"1576501":{"node_type":"metabolite","x":3625.7841796875,"y":1147.3958740234375,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":3556.820068359375,"label_y":1187.06494140625,"node_is_primary":true},"1576502":{"node_type":"metabolite","x":2715,"y":2921,"bigg_id":"h2o_c","name":"H2O","label_x":2693.4130859375,"label_y":2896.71923828125,"node_is_primary":false},"1576503":{"node_type":"metabolite","x":2843,"y":2920,"bigg_id":"fum_c","name":"Fumarate","label_x":2867.189453125,"label_y":2939.602783203125,"node_is_primary":true},"1576504":{"node_type":"metabolite","x":2621,"y":3192,"bigg_id":"mal__L_c","name":"L-Malate","label_x":2506.83544921875,"label_y":3174.826416015625,"node_is_primary":true},"1576505":{"node_type":"metabolite","x":3413,"y":3976,"bigg_id":"icit_c","name":"Isocitrate","label_x":3344.32373046875,"label_y":3949.222900390625,"node_is_primary":true},"1576506":{"node_type":"metabolite","x":3495,"y":4065,"bigg_id":"nadp_c","name":"Nicotinamide adenine dinucleotide phosphate","label_x":3495,"label_y":4098,"node_is_primary":false},"1576507":{"node_type":"metabolite","x":3659,"y":3660,"bigg_id":"nadph_c","name":"Nicotinamide adenine dinucleotide phosphate - reduced","label_x":3557.6474609375,"label_y":3655.388427734375,"node_is_primary":false},"1576508":{"node_type":"metabolite","x":3620,"y":3710,"bigg_id":"co2_c","name":"CO2","label_x":3539.820068359375,"label_y":3711.611572265625,"node_is_primary":false},"1576509":{"node_type":"metabolite","x":3746,"y":3627,"bigg_id":"akg_c","name":"2-Oxoglutarate","label_x":3669.712158203125,"label_y":3611.942626953125,"node_is_primary":true},"1576510":{"node_type":"metabolite","x":1365,"y":3855,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":1394.189697265625,"label_y":3851.826416015625,"node_is_primary":false},"1576511":{"node_type":"metabolite","x":1055,"y":3945,"bigg_id":"pyr_c","name":"Pyruvate","label_x":1025,"label_y":3965,"node_is_primary":true},"1576512":{"node_type":"metabolite","x":1315,"y":3905,"bigg_id":"coa_c","name":"Coenzyme A","label_x":1287.066162109375,"label_y":3887.545654296875,"node_is_primary":false},"1576513":{"node_type":"metabolite","x":1605,"y":3855,"bigg_id":"co2_c","name":"CO2","label_x":1595,"label_y":3835,"node_is_primary":false},"1576514":{"node_type":"metabolite","x":1715,"y":3945,"bigg_id":"accoa_c","name":"Acetyl-CoA","label_x":1695,"label_y":3965,"node_is_primary":true},"1576515":{"node_type":"metabolite","x":1655,"y":3885,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":1647.545654296875,"label_y":3855.4794921875,"node_is_primary":false},"1576516":{"node_type":"metabolite","x":1295,"y":3375,"bigg_id":"h2o_c","name":"H2O","label_x":1315,"label_y":3375,"node_is_primary":false},"1576517":{"node_type":"metabolite","x":1055,"y":3375,"bigg_id":"pep_c","name":"Phosphoenolpyruvate","label_x":1085,"label_y":3355,"node_is_primary":true},"1576518":{"node_type":"metabolite","x":1205,"y":3345,"bigg_id":"co2_c","name":"CO2","label_x":1215,"label_y":3325,"node_is_primary":false},"1576519":{"node_type":"metabolite","x":1615,"y":3475,"bigg_id":"h_c","name":"H+","label_x":1635,"label_y":3475,"node_is_primary":false},"1576520":{"node_type":"metabolite","x":1665,"y":3515,"bigg_id":"pi_c","name":"Phosphate","label_x":1685,"label_y":3515,"node_is_primary":false},"1576521":{"node_type":"metabolite","x":2659,"y":3724,"bigg_id":"oaa_c","name":"Oxaloacetate","label_x":2692,"label_y":3724,"node_is_primary":true},"1576522":{"node_type":"metabolite","x":1055,"y":3125,"bigg_id":"2pg_c","name":"D-Glycerate 2-phosphate","label_x":1093,"label_y":3125,"node_is_primary":true},"1576523":{"node_type":"metabolite","x":965,"y":3325,"bigg_id":"h2o_c","name":"H2O","label_x":886.289794921875,"label_y":3307.958740234375,"node_is_primary":false},"1576524":{"node_type":"metabolite","x":1055,"y":1265,"bigg_id":"g6p_c","name":"D-Glucose 6-phosphate","label_x":1075,"label_y":1245,"node_is_primary":true},"1576525":{"node_type":"metabolite","x":1055,"y":1545,"bigg_id":"f6p_c","name":"D-Fructose 6-phosphate","label_x":1075,"label_y":1525,"node_is_primary":true},"1576526":{"node_type":"metabolite","x":3989,"y":4757,"bigg_id":"nh4_e","name":"Ammonium","label_x":4019,"label_y":4757,"node_is_primary":true},"1576527":{"node_type":"metabolite","x":3989,"y":4441,"bigg_id":"nh4_c","name":"Ammonium","label_x":4019,"label_y":4441,"node_is_primary":true},"1576528":{"node_type":"metabolite","x":765,"y":1855,"bigg_id":"h2o_c","name":"H2O","label_x":672.9427490234375,"label_y":1861.3470458984375,"node_is_primary":false},"1576529":{"node_type":"metabolite","x":1055,"y":1925,"bigg_id":"fdp_c","name":"D-Fructose 1,6-bisphosphate","label_x":1096.404296875,"label_y":1928.173583984375,"node_is_primary":true},"1576530":{"node_type":"metabolite","x":755,"y":1565,"bigg_id":"pi_c","name":"Phosphate","label_x":686.744140625,"label_y":1563.4132080078125,"node_is_primary":false},"1576531":{"node_type":"metabolite","x":4932,"y":2880,"bigg_id":"succ_e","name":"Succinate","label_x":4950.4462890625,"label_y":2915.280517578125,"node_is_primary":true},"1576532":{"node_type":"metabolite","x":3180,"y":3570,"bigg_id":"glx_c","name":"Glyoxylate","label_x":3211.3271484375,"label_y":3543.267578125,"node_is_primary":true},"1576533":{"node_type":"metabolite","x":3420,"y":2867,"bigg_id":"succ_c","name":"Succinate","label_x":3439.01611328125,"label_y":2838.810302734375,"node_is_primary":true},"1576534":{"node_type":"metabolite","x":4215,"y":1040,"bigg_id":"atp_c","name":"ATP","label_x":4215,"label_y":1010,"node_is_primary":true},"1576535":{"node_type":"metabolite","x":4065,"y":1070,"bigg_id":"amp_c","name":"AMP","label_x":4033.388427734375,"label_y":1030.661865234375,"node_is_primary":true},"1576536":{"node_type":"metabolite","x":4215,"y":1510,"bigg_id":"adp_c","name":"ADP","label_x":4196.611328125,"label_y":1556.1151123046875,"node_is_primary":true},"1576537":{"node_type":"metabolite","x":4882,"y":4158,"bigg_id":"gln__L_e","name":"L-Glutamine","label_x":4851.38134765625,"label_y":4199.2802734375,"node_is_primary":true},"1576539":{"node_type":"metabolite","x":4758.67626953125,"y":2215.0361328125,"bigg_id":"q8_c","name":"Ubiquinone-8","label_x":4686.61181640625,"label_y":2192.47509765625,"node_is_primary":true},"1576542":{"node_type":"metabolite","x":4508.47509765625,"y":2210.3310546875,"bigg_id":"q8h2_c","name":"Ubiquinol-8","label_x":4411.00048828125,"label_y":2217.395751953125,"node_is_primary":true},"1576544":{"node_type":"metabolite","x":3621,"y":4754,"bigg_id":"co2_e","name":"CO2","label_x":3651,"label_y":4754,"node_is_primary":true},"1576545":{"node_type":"metabolite","x":2358.984130859375,"y":1865,"bigg_id":"g3p_c","name":"Glyceraldehyde 3-phosphate","label_x":2375.091552734375,"label_y":1898.4132080078125,"node_is_primary":true},"1576546":{"node_type":"metabolite","x":1983.082275390625,"y":1865,"bigg_id":"s7p_c","name":"Sedoheptulose 7-phosphate","label_x":1955.8675537109375,"label_y":1814.314697265625,"node_is_primary":true},"1576547":{"node_type":"metabolite","x":1945,"y":2190,"bigg_id":"e4p_c","name":"D-Erythrose 4-phosphate","label_x":1922.7852783203125,"label_y":2242.214599609375,"node_is_primary":true},"1576548":{"node_type":"metabolite","x":2362.636962890625,"y":2186.826416015625,"bigg_id":"f6p_c","name":"D-Fructose 6-phosphate","label_x":2367.636962890625,"label_y":2216.826416015625,"node_is_primary":true},"1576549":{"node_type":"metabolite","x":965,"y":3625,"bigg_id":"h_c","name":"H+","label_x":911.677978515625,"label_y":3612.305908203125,"node_is_primary":false},"1576550":{"node_type":"metabolite","x":965,"y":3555,"bigg_id":"adp_c","name":"ADP","label_x":903.744140625,"label_y":3528.02490234375,"node_is_primary":false},"1576551":{"node_type":"metabolite","x":965,"y":3815,"bigg_id":"atp_c","name":"ATP","label_x":929.1323852539062,"label_y":3794.372314453125,"node_is_primary":false},"1576552":{"node_type":"metabolite","x":4883,"y":3634,"bigg_id":"glu__L_e","name":"L-Glutamate","label_x":4883,"label_y":3604,"node_is_primary":true},"1576553":{"node_type":"metabolite","x":4825,"y":3703,"bigg_id":"h_e","name":"H+","label_x":4857.23046875,"label_y":3723,"node_is_primary":false},"1576554":{"node_type":"metabolite","x":4248,"y":3632,"bigg_id":"glu__L_c","name":"L-Glutamate","label_x":4221.2158203125,"label_y":3601,"node_is_primary":true},"1576555":{"node_type":"metabolite","x":4478,"y":3688,"bigg_id":"h_c","name":"H+","label_x":4503.1796875,"label_y":3696.834716796875,"node_is_primary":false},"1576556":{"node_type":"metabolite","x":1055,"y":4835,"bigg_id":"lac__D_e","name":"D-Lactate","label_x":1088.470458984375,"label_y":4857.21484375,"node_is_primary":true},"1576557":{"node_type":"metabolite","x":275,"y":3945,"bigg_id":"pyr_e","name":"Pyruvate","label_x":249.61181640625,"label_y":3994.041015625,"node_is_primary":true},"1576558":{"node_type":"metabolite","x":1945,"y":1555,"bigg_id":"xu5p__D_c","name":"D-Xylulose 5-phosphate","label_x":1944.76025390625,"label_y":1599.5205078125,"node_is_primary":true},"1576559":{"node_type":"metabolite","x":4850,"y":2229,"bigg_id":"h_e","name":"H+","label_x":4867.7265625,"label_y":2273.503662109375,"node_is_primary":true},"1576567":{"node_type":"metabolite","x":3460,"y":2960,"bigg_id":"coa_c","name":"Coenzyme A","label_x":3448.892578125,"label_y":2991.107421875,"node_is_primary":false},"1576568":{"node_type":"metabolite","x":3500,"y":3030,"bigg_id":"atp_c","name":"ATP","label_x":3496.826416015625,"label_y":3062.694091796875,"node_is_primary":false},"1576569":{"node_type":"metabolite","x":3794,"y":3051,"bigg_id":"pi_c","name":"Phosphate","label_x":3814,"label_y":3051,"node_is_primary":false},"1576570":{"node_type":"metabolite","x":3739,"y":3193,"bigg_id":"succoa_c","name":"Succinyl-CoA","label_x":3772.230712890625,"label_y":3193.479248046875,"node_is_primary":true},"1576571":{"node_type":"metabolite","x":3768,"y":3116,"bigg_id":"adp_c","name":"ADP","label_x":3788,"label_y":3126,"node_is_primary":false},"1576572":{"node_type":"metabolite","x":1145,"y":1645,"bigg_id":"atp_c","name":"ATP","label_x":1165,"label_y":1645,"node_is_primary":false},"1576573":{"node_type":"metabolite","x":1145,"y":1805,"bigg_id":"adp_c","name":"ADP","label_x":1165,"label_y":1805,"node_is_primary":false},"1576574":{"node_type":"metabolite","x":1145,"y":1855,"bigg_id":"h_c","name":"H+","label_x":1165,"label_y":1855,"node_is_primary":false},"1576575":{"node_type":"metabolite","x":1055,"y":2195,"bigg_id":"g3p_c","name":"Glyceraldehyde 3-phosphate","label_x":1085,"label_y":2195,"node_is_primary":true},"1576576":{"node_type":"metabolite","x":4440,"y":3755,"bigg_id":"atp_c","name":"ATP","label_x":4474,"label_y":3753,"node_is_primary":false},"1576577":{"node_type":"metabolite","x":4440,"y":3805,"bigg_id":"nh4_c","name":"Ammonium","label_x":4477,"label_y":3811,"node_is_primary":false},"1576578":{"node_type":"metabolite","x":4246,"y":4094,"bigg_id":"gln__L_c","name":"L-Glutamine","label_x":4245,"label_y":4130,"node_is_primary":true},"1576579":{"node_type":"metabolite","x":4434,"y":3954,"bigg_id":"adp_c","name":"ADP","label_x":4454,"label_y":3954,"node_is_primary":false},"1576580":{"node_type":"metabolite","x":4434,"y":4004,"bigg_id":"h_c","name":"H+","label_x":4454,"label_y":4004,"node_is_primary":false},"1576581":{"node_type":"metabolite","x":4434,"y":4054,"bigg_id":"pi_c","name":"Phosphate","label_x":4454,"label_y":4054,"node_is_primary":false},"1576584":{"node_type":"metabolite","x":1055,"y":4345,"bigg_id":"lac__D_c","name":"D-Lactate","label_x":1089,"label_y":4349,"node_is_primary":true},"1576585":{"node_type":"metabolite","x":3684,"y":3506,"bigg_id":"coa_c","name":"Coenzyme A","label_x":3628.99267578125,"label_y":3483.05029296875,"node_is_primary":false},"1576586":{"node_type":"metabolite","x":3684,"y":3558,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":3606.208740234375,"label_y":3539.885009765625,"node_is_primary":false},"1576587":{"node_type":"metabolite","x":3872,"y":3285,"bigg_id":"co2_c","name":"CO2","label_x":3898,"label_y":3285,"node_is_primary":false},"1576588":{"node_type":"metabolite","x":3820,"y":3233,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":3846,"label_y":3233,"node_is_primary":false},"1576589":{"node_type":"metabolite","x":1165,"y":4045,"bigg_id":"coa_c","name":"Coenzyme A","label_x":1165,"label_y":4065,"node_is_primary":false},"1576590":{"node_type":"metabolite","x":1460,"y":4095,"bigg_id":"for_c","name":"Formate","label_x":1495.230712890625,"label_y":4083.958984375,"node_is_primary":true},"1576591":{"node_type":"metabolite","x":1505,"y":3625,"bigg_id":"atp_c","name":"ATP","label_x":1525,"label_y":3625,"node_is_primary":false},"1576592":{"node_type":"metabolite","x":1285,"y":3545,"bigg_id":"adp_c","name":"ADP","label_x":1285,"label_y":3575,"node_is_primary":false},"1576593":{"node_type":"metabolite","x":1215,"y":3515,"bigg_id":"co2_c","name":"CO2","label_x":1215,"label_y":3535,"node_is_primary":false},"1576594":{"node_type":"metabolite","x":2880,"y":4839,"bigg_id":"pi_e","name":"Phosphate","label_x":2910,"label_y":4839,"node_is_primary":true},"1576595":{"node_type":"metabolite","x":2793,"y":4778,"bigg_id":"h_e","name":"H+","label_x":2733.83544921875,"label_y":4763.8515625,"node_is_primary":false},"1576596":{"node_type":"metabolite","x":2793,"y":4452,"bigg_id":"h_c","name":"H+","label_x":2754.13232421875,"label_y":4426.61181640625,"node_is_primary":false},"1576597":{"node_type":"metabolite","x":2880,"y":4430,"bigg_id":"pi_c","name":"Phosphate","label_x":2921,"label_y":4428,"node_is_primary":true},"1576598":{"node_type":"metabolite","x":4922,"y":3228,"bigg_id":"akg_e","name":"2-Oxoglutarate","label_x":4922,"label_y":3268,"node_is_primary":true},"1576599":{"node_type":"metabolite","x":4834,"y":3321,"bigg_id":"h_e","name":"H+","label_x":4861.39599609375,"label_y":3334.553955078125,"node_is_primary":false},"1576600":{"node_type":"metabolite","x":4472,"y":3328,"bigg_id":"h_c","name":"H+","label_x":4490.337890625,"label_y":3342.330810546875,"node_is_primary":false},"1576601":{"node_type":"metabolite","x":855,"y":2195,"bigg_id":"dhap_c","name":"Dihydroxyacetone phosphate","label_x":739.3148193359375,"label_y":2179.132568359375,"node_is_primary":true},"1576602":{"node_type":"metabolite","x":4301.69775390625,"y":1895.1654052734375,"bigg_id":"h_c","name":"H+","label_x":4234.01416015625,"label_y":1903.8848876953125,"node_is_primary":false},"1576603":{"node_type":"metabolite","x":4860,"y":1900,"bigg_id":"h_e","name":"H+","label_x":4858.38818359375,"label_y":1950.6187744140625,"node_is_primary":false},"1576604":{"node_type":"metabolite","x":4439.09375,"y":1760.9495849609375,"bigg_id":"h2o_c","name":"H2O","label_x":4452.77001953125,"label_y":1736.77685546875,"node_is_primary":false},"1576605":{"node_type":"metabolite","x":2419,"y":1555,"bigg_id":"r5p_c","name":"Alpha-D-Ribose 5-phosphate","label_x":2418.413330078125,"label_y":1601.1072998046875,"node_is_primary":true},"1576606":{"node_type":"metabolite","x":3105,"y":3402,"bigg_id":"accoa_c","name":"Acetyl-CoA","label_x":3125,"label_y":3402,"node_is_primary":false},"1576607":{"node_type":"metabolite","x":3170,"y":3480,"bigg_id":"h2o_c","name":"H2O","label_x":3190,"label_y":3480,"node_is_primary":false},"1576608":{"node_type":"metabolite","x":2871,"y":3220,"bigg_id":"h_c","name":"H+","label_x":2891,"label_y":3220,"node_is_primary":false},"1576609":{"node_type":"metabolite","x":2780,"y":3168,"bigg_id":"coa_c","name":"Coenzyme A","label_x":2800,"label_y":3168,"node_is_primary":false},"1576612":{"node_type":"metabolite","x":1815,"y":4035,"bigg_id":"pi_c","name":"Phosphate","label_x":1835,"label_y":4035,"node_is_primary":false},"1576613":{"node_type":"metabolite","x":1715,"y":4175,"bigg_id":"actp_c","name":"Acetyl phosphate","label_x":1745,"label_y":4175,"node_is_primary":true},"1576614":{"node_type":"metabolite","x":1815,"y":4135,"bigg_id":"coa_c","name":"Coenzyme A","label_x":1835,"label_y":4135,"node_is_primary":false},"1576615":{"node_type":"metabolite","x":4535,"y":4258,"bigg_id":"atp_c","name":"ATP","label_x":4552.7265625,"label_y":4269.94287109375,"node_is_primary":false},"1576616":{"node_type":"metabolite","x":4485,"y":4258,"bigg_id":"h2o_c","name":"H2O","label_x":4481.77685546875,"label_y":4287.6689453125,"node_is_primary":false},"1576617":{"node_type":"metabolite","x":4285,"y":4258,"bigg_id":"pi_c","name":"Phosphate","label_x":4268.884765625,"label_y":4287.6689453125,"node_is_primary":false},"1576618":{"node_type":"metabolite","x":4385,"y":4258,"bigg_id":"adp_c","name":"ADP","label_x":4381.77685546875,"label_y":4290.89208984375,"node_is_primary":false},"1576619":{"node_type":"metabolite","x":4335,"y":4258,"bigg_id":"h_c","name":"H+","label_x":4331.77734375,"label_y":4286.0576171875,"node_is_primary":false},"1576620":{"node_type":"metabolite","x":2360,"y":3220,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":2380,"label_y":3220,"node_is_primary":false},"1576621":{"node_type":"metabolite","x":2060,"y":3420,"bigg_id":"co2_c","name":"CO2","label_x":1979.703125,"label_y":3415.23974609375,"node_is_primary":false},"1576622":{"node_type":"metabolite","x":2080,"y":3370,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":1994.9427490234375,"label_y":3350.958740234375,"node_is_primary":false},"1576623":{"node_type":"metabolite","x":1257,"y":1160,"bigg_id":"nadp_c","name":"Nicotinamide adenine dinucleotide phosphate","label_x":1257,"label_y":1140,"node_is_primary":false},"1576624":{"node_type":"metabolite","x":1407,"y":1160,"bigg_id":"nadph_c","name":"Nicotinamide adenine dinucleotide phosphate - reduced","label_x":1430,"label_y":1140,"node_is_primary":false},"1576625":{"node_type":"metabolite","x":1357,"y":1160,"bigg_id":"h_c","name":"H+","label_x":1357,"label_y":1140,"node_is_primary":false},"1576626":{"node_type":"metabolite","x":1507,"y":1265,"bigg_id":"6pgl_c","name":"6-phospho-D-glucono-1,5-lactone","label_x":1507,"label_y":1235,"node_is_primary":true},"1576627":{"node_type":"metabolite","x":1715,"y":4845,"bigg_id":"ac_e","name":"Acetate","label_x":1759.0985107421875,"label_y":4848.173828125,"node_is_primary":true},"1576628":{"node_type":"metabolite","x":4201,"y":3940,"bigg_id":"h2o_c","name":"H2O","label_x":4175.82763671875,"label_y":3972.89208984375,"node_is_primary":false},"1576629":{"node_type":"metabolite","x":4193,"y":3762,"bigg_id":"nh4_c","name":"Ammonium","label_x":4160.99267578125,"label_y":3793.22314453125,"node_is_primary":false},"1576630":{"node_type":"metabolite","x":4275,"y":1140,"bigg_id":"h2o_c","name":"H2O","label_x":4295,"label_y":1140,"node_is_primary":false},"1576631":{"node_type":"metabolite","x":4285,"y":1450,"bigg_id":"pi_c","name":"Phosphate","label_x":4305,"label_y":1450,"node_is_primary":false},"1576632":{"node_type":"metabolite","x":4285,"y":1380,"bigg_id":"h_c","name":"H+","label_x":4305,"label_y":1380,"node_is_primary":false},"1576633":{"node_type":"metabolite","x":955,"y":4255,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":935,"label_y":4255,"node_is_primary":false},"1576634":{"node_type":"metabolite","x":955,"y":4045,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":935,"label_y":4045,"node_is_primary":false},"1576635":{"node_type":"metabolite","x":955,"y":4095,"bigg_id":"h_c","name":"H+","label_x":935,"label_y":4095,"node_is_primary":false},"1576636":{"node_type":"metabolite","x":2670,"y":3310,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":2690,"label_y":3320,"node_is_primary":false},"1576637":{"node_type":"metabolite","x":2680,"y":3585,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":2710,"label_y":3590,"node_is_primary":false},"1576638":{"node_type":"metabolite","x":2660,"y":3510,"bigg_id":"h_c","name":"H+","label_x":2692,"label_y":3510,"node_is_primary":false},"1576639":{"node_type":"metabolite","x":3257,"y":4754,"bigg_id":"h2o_e","name":"H2O","label_x":3287,"label_y":4754,"node_is_primary":true},"1576640":{"node_type":"metabolite","x":3257,"y":4434,"bigg_id":"h2o_c","name":"H2O","label_x":3287,"label_y":4434,"node_is_primary":true},"1576641":{"node_type":"metabolite","x":3621,"y":4434,"bigg_id":"co2_c","name":"CO2","label_x":3651,"label_y":4434,"node_is_primary":true},"1576642":{"node_type":"metabolite","x":735,"y":3855,"bigg_id":"atp_c","name":"ATP","label_x":670.5706176757812,"label_y":3840.71923828125,"node_is_primary":false},"1576643":{"node_type":"metabolite","x":735,"y":3805,"bigg_id":"h2o_c","name":"H2O","label_x":681.677978515625,"label_y":3787.545654296875,"node_is_primary":false},"1576644":{"node_type":"metabolite","x":735,"y":3475,"bigg_id":"h_c","name":"H+","label_x":672.1574096679688,"label_y":3478.173583984375,"node_is_primary":false},"1576645":{"node_type":"metabolite","x":735,"y":3525,"bigg_id":"amp_c","name":"AMP","label_x":640.4221801757812,"label_y":3545.6279296875,"node_is_primary":false},"1576646":{"node_type":"metabolite","x":735,"y":3425,"bigg_id":"pi_c","name":"Phosphate","label_x":684.8515014648438,"label_y":3409.13232421875,"node_is_primary":false},"1576647":{"node_type":"metabolite","x":1055.066162109375,"y":705,"bigg_id":"glc__D_e","name":"D-Glucose","label_x":1085.066162109375,"label_y":705,"node_is_primary":true},"1576648":{"node_type":"metabolite","x":2600,"y":4760,"bigg_id":"h_e","name":"H+","label_x":2620,"label_y":4760,"node_is_primary":false},"1576649":{"node_type":"metabolite","x":2500,"y":4830,"bigg_id":"etoh_e","name":"Ethanol","label_x":2530,"label_y":4830,"node_is_primary":true},"1576650":{"node_type":"metabolite","x":2600,"y":4400,"bigg_id":"h_c","name":"H+","label_x":2620,"label_y":4400,"node_is_primary":false},"1576651":{"node_type":"metabolite","x":1815,"y":4335,"bigg_id":"atp_c","name":"ATP","label_x":1835,"label_y":4335,"node_is_primary":false},"1576652":{"node_type":"metabolite","x":1715,"y":4385,"bigg_id":"ac_c","name":"Acetate","label_x":1745,"label_y":4385,"node_is_primary":true},"1576653":{"node_type":"metabolite","x":1815,"y":4225,"bigg_id":"adp_c","name":"ADP","label_x":1835,"label_y":4225,"node_is_primary":false},"1576654":{"node_type":"metabolite","x":4029,"y":3932,"bigg_id":"nadph_c","name":"Nicotinamide adenine dinucleotide phosphate - reduced","label_x":3993.9423828125,"label_y":3909.05029296875,"node_is_primary":false},"1576655":{"node_type":"metabolite","x":4029,"y":3982,"bigg_id":"h_c","name":"H+","label_x":4002,"label_y":3986,"node_is_primary":false},"1576656":{"node_type":"metabolite","x":4043,"y":3759,"bigg_id":"nadp_c","name":"Nicotinamide adenine dinucleotide phosphate","label_x":3957.985595703125,"label_y":3736.215576171875,"node_is_primary":false},"1576657":{"node_type":"metabolite","x":2840,"y":650,"bigg_id":"fum_e","name":"Fumarate","label_x":2879.817626953125,"label_y":635.0911865234375,"node_is_primary":true},"1576658":{"node_type":"metabolite","x":2940,"y":700,"bigg_id":"h_e","name":"H+","label_x":2962.214599609375,"label_y":718.4132080078125,"node_is_primary":false},"1576659":{"node_type":"metabolite","x":2940,"y":1010,"bigg_id":"h_c","name":"H+","label_x":2954.28076171875,"label_y":1038.4132080078125,"node_is_primary":false},"1576660":{"node_type":"metabolite","x":1815,"y":4775,"bigg_id":"h_e","name":"H+","label_x":1835,"label_y":4775,"node_is_primary":false},"1576661":{"node_type":"metabolite","x":1819.76025390625,"y":4452.45458984375,"bigg_id":"h_c","name":"H+","label_x":1839.76025390625,"label_y":4452.45458984375,"node_is_primary":false},"1576662":{"node_type":"metabolite","x":957.694091796875,"y":974.4060668945312,"bigg_id":"pep_c","name":"Phosphoenolpyruvate","label_x":877.8765258789062,"label_y":976.9517211914062,"node_is_primary":false},"1576663":{"node_type":"metabolite","x":1161.3470458984375,"y":972.8192138671875,"bigg_id":"pyr_c","name":"Pyruvate","label_x":1193.082275390625,"label_y":986.47216796875,"node_is_primary":false},"1576664":{"node_type":"metabolite","x":4791.7197265625,"y":2921.942138671875,"bigg_id":"h_e","name":"H+","label_x":4818.7197265625,"label_y":2921.942138671875,"node_is_primary":false},"1576665":{"node_type":"metabolite","x":4461.380859375,"y":2763.553955078125,"bigg_id":"h_c","name":"H+","label_x":4389.423828125,"label_y":2763.9423828125,"node_is_primary":false},"1576666":{"node_type":"metabolite","x":1460,"y":4843.322265625,"bigg_id":"for_e","name":"Formate","label_x":1500,"label_y":4843.322265625,"node_is_primary":true},"1576667":{"node_type":"metabolite","x":1587,"y":1160,"bigg_id":"h2o_c","name":"H2O","label_x":1587,"label_y":1140,"node_is_primary":false},"1576668":{"node_type":"metabolite","x":1687,"y":1160,"bigg_id":"h_c","name":"H+","label_x":1687,"label_y":1140,"node_is_primary":false},"1576669":{"node_type":"metabolite","x":1145,"y":2265,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":1165,"label_y":2265,"node_is_primary":false},"1576670":{"node_type":"metabolite","x":1145,"y":2315,"bigg_id":"pi_c","name":"Phosphate","label_x":1165,"label_y":2315,"node_is_primary":false},"1576671":{"node_type":"metabolite","x":1145,"y":2515,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":1165,"label_y":2515,"node_is_primary":false},"1576672":{"node_type":"metabolite","x":1145,"y":2465,"bigg_id":"h_c","name":"H+","label_x":1169,"label_y":2465,"node_is_primary":false},"1576673":{"node_type":"metabolite","x":4836,"y":3087,"bigg_id":"h_e","name":"H+","label_x":4836,"label_y":3115,"node_is_primary":false},"1576674":{"node_type":"metabolite","x":4456,"y":3087,"bigg_id":"h_c","name":"H+","label_x":4456,"label_y":3109,"node_is_primary":false},"1576675":{"node_type":"metabolite","x":4192,"y":3558,"bigg_id":"h2o_c","name":"H2O","label_x":4210,"label_y":3530,"node_is_primary":false},"1576676":{"node_type":"metabolite","x":4142,"y":3558,"bigg_id":"nadp_c","name":"Nicotinamide adenine dinucleotide phosphate","label_x":4142,"label_y":3528,"node_is_primary":false},"1576677":{"node_type":"metabolite","x":3992,"y":3558,"bigg_id":"nadph_c","name":"Nicotinamide adenine dinucleotide phosphate - reduced","label_x":3935.431640625,"label_y":3532.22314453125,"node_is_primary":false},"1576678":{"node_type":"metabolite","x":3942,"y":3558,"bigg_id":"nh4_c","name":"Ammonium","label_x":3856.820068359375,"label_y":3573.222900390625,"node_is_primary":false},"1576679":{"node_type":"metabolite","x":4042,"y":3558,"bigg_id":"h_c","name":"H+","label_x":4050,"label_y":3530,"node_is_primary":false},"1576680":{"node_type":"metabolite","x":4865,"y":1150,"bigg_id":"h_e","name":"H+","label_x":4865,"label_y":1180,"node_is_primary":false},"1576681":{"node_type":"metabolite","x":4495,"y":1330,"bigg_id":"pi_c","name":"Phosphate","label_x":4459.546875,"label_y":1293.5970458984375,"node_is_primary":false},"1576682":{"node_type":"metabolite","x":4415,"y":1150,"bigg_id":"h_c","name":"H+","label_x":4398.884765625,"label_y":1187.7266845703125,"node_is_primary":false},"1576683":{"node_type":"metabolite","x":4482.7265625,"y":1030,"bigg_id":"h2o_c","name":"H2O","label_x":4482.7265625,"label_y":1010,"node_is_primary":false},"1576684":{"node_type":"metabolite","x":2610,"y":3860,"bigg_id":"h2o_c","name":"H2O","label_x":2599.520751953125,"label_y":3890.1484375,"node_is_primary":false},"1576685":{"node_type":"metabolite","x":2971,"y":3986,"bigg_id":"cit_c","name":"Citrate","label_x":2972.653076171875,"label_y":3943.1826171875,"node_is_primary":true},"1576686":{"node_type":"metabolite","x":2806,"y":4091,"bigg_id":"coa_c","name":"Coenzyme A","label_x":2786.826416015625,"label_y":4132.21484375,"node_is_primary":false},"1576687":{"node_type":"metabolite","x":2897,"y":4117,"bigg_id":"h_c","name":"H+","label_x":2899.041015625,"label_y":4155.8671875,"node_is_primary":false},"1576688":{"node_type":"metabolite","x":345,"y":4045,"bigg_id":"h_e","name":"H+","label_x":351.3470764160156,"label_y":4072.933837890625,"node_is_primary":false},"1576689":{"node_type":"metabolite","x":675,"y":4045,"bigg_id":"h_c","name":"H+","label_x":675,"label_y":4077.694091796875,"node_is_primary":false},"1576690":{"node_type":"metabolite","x":2430,"y":3370,"bigg_id":"nadp_c","name":"Nicotinamide adenine dinucleotide phosphate","label_x":2450,"label_y":3370,"node_is_primary":false},"1576691":{"node_type":"metabolite","x":2260,"y":3510,"bigg_id":"co2_c","name":"CO2","label_x":2280,"label_y":3510,"node_is_primary":false},"1576692":{"node_type":"metabolite","x":2200,"y":3540,"bigg_id":"nadph_c","name":"Nicotinamide adenine dinucleotide phosphate - reduced","label_x":2220,"label_y":3550,"node_is_primary":false},"1576808":{"node_type":"metabolite","x":4850,"y":2570,"bigg_id":"h_e","name":"H+","label_x":4874.1728515625,"label_y":2601.280517578125,"node_is_primary":false},"1576809":{"node_type":"metabolite","x":4449.00732421875,"y":2646.77685546875,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":4356.72412109375,"label_y":2646.95849609375,"node_is_primary":true},"1576810":{"node_type":"metabolite","x":2510,"y":1010,"bigg_id":"h_c","name":"H+","label_x":2473.50439453125,"label_y":1043.1734619140625,"node_is_primary":false},"1576811":{"node_type":"metabolite","x":1270,"y":4440,"bigg_id":"h_c","name":"H+","label_x":1245.23974609375,"label_y":4424.13232421875,"node_is_primary":false},"1576812":{"node_type":"metabolite","x":1890,"y":3860,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":1868.892578125,"label_y":3840.810302734375,"node_is_primary":false},"1576813":{"node_type":"metabolite","x":2392,"y":3980,"bigg_id":"h_c","name":"H+","label_x":2406,"label_y":3965,"node_is_primary":false},"1576814":{"node_type":"metabolite","x":3210,"y":2730,"bigg_id":"q8_c","name":"Ubiquinone-8","label_x":3228.082275390625,"label_y":2736.34716796875,"node_is_primary":false},"1576815":{"node_type":"metabolite","x":2210,"y":4837.65283203125,"bigg_id":"acald_e","name":"Acetaldehyde","label_x":2240,"label_y":4837.65283203125,"node_is_primary":true},"1576816":{"node_type":"metabolite","x":2610,"y":650,"bigg_id":"mal__L_e","name":"L-Malate","label_x":2640,"label_y":630,"node_is_primary":true},"1576817":{"node_type":"metabolite","x":2210,"y":3945,"bigg_id":"acald_c","name":"Acetaldehyde","label_x":2210,"label_y":3905,"node_is_primary":true},"1576819":{"node_type":"metabolite","x":565.6046142578125,"y":1448.4132080078125,"bigg_id":"pep_c","name":"Phosphoenolpyruvate","label_x":554.497314453125,"label_y":1479.5206298828125,"node_is_primary":false},"1576820":{"node_type":"metabolite","x":4310,"y":2570,"bigg_id":"h_c","name":"H+","label_x":4273.546875,"label_y":2604.6689453125,"node_is_primary":false},"1576821":{"node_type":"metabolite","x":714.76025390625,"y":1237.785400390625,"bigg_id":"pyr_c","name":"Pyruvate","label_x":692.5455932617188,"label_y":1207.785400390625,"node_is_primary":false},"1576822":{"node_type":"metabolite","x":2482,"y":4065,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":2496,"label_y":4051,"node_is_primary":false},"1576824":{"node_type":"metabolite","x":2333,"y":3935,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":2347,"label_y":3921,"node_is_primary":false},"1576825":{"node_type":"metabolite","x":2130,"y":3860,"bigg_id":"coa_c","name":"Coenzyme A","label_x":2140,"label_y":3840,"node_is_primary":false},"1576826":{"node_type":"metabolite","x":300,"y":1360,"bigg_id":"fru_e","name":"D-Fructose","label_x":284.1323547363281,"label_y":1405.8675537109375,"node_is_primary":true},"1576827":{"node_type":"metabolite","x":4417.8271484375,"y":2478.91357421875,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":4322.0859375,"label_y":2462.79833984375,"node_is_primary":true},"1576828":{"node_type":"metabolite","x":2070,"y":3860,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":2070,"label_y":3840,"node_is_primary":false},"1576829":{"node_type":"metabolite","x":2501,"y":4228,"bigg_id":"etoh_c","name":"Ethanol","label_x":2522,"label_y":4206,"node_is_primary":true},"1576830":{"node_type":"metabolite","x":3020,"y":2740,"bigg_id":"q8h2_c","name":"Ubiquinol-8","label_x":3041.5869140625,"label_y":2740,"node_is_primary":false},"1576831":{"node_type":"metabolite","x":2510,"y":700,"bigg_id":"h_e","name":"H+","label_x":2460.1826171875,"label_y":722.5455932617188,"node_is_primary":false},"1576832":{"node_type":"metabolite","x":1950,"y":3860,"bigg_id":"h_c","name":"H+","label_x":1950,"label_y":3840,"node_is_primary":false},"1576833":{"node_type":"metabolite","x":1270,"y":4770,"bigg_id":"h_e","name":"H+","label_x":1228.8927001953125,"label_y":4750.95849609375,"node_is_primary":false},"1576834":{"node_type":"multimarker","x":1055,"y":2665},"1576835":{"node_type":"multimarker","x":1055,"y":2775},"1576836":{"node_type":"midmarker","x":1055,"y":2725},"1576837":{"node_type":"midmarker","x":1957,"y":1265},"1576838":{"node_type":"multimarker","x":1937,"y":1265},"1576839":{"node_type":"multimarker","x":1977,"y":1265},"1576840":{"node_type":"midmarker","x":4660,"y":1660},"1576841":{"node_type":"midmarker","x":3510,"y":820},"1576842":{"node_type":"multimarker","x":3510,"y":800},"1576843":{"node_type":"multimarker","x":3510,"y":870},"1576844":{"node_type":"multimarker","x":2727,"y":3022},"1576845":{"node_type":"midmarker","x":2684,"y":3076},"1576846":{"node_type":"midmarker","x":3606,"y":3846},"1576847":{"node_type":"multimarker","x":3512,"y":3923},"1576848":{"node_type":"multimarker","x":3663,"y":3781},"1576849":{"node_type":"multimarker","x":1430,"y":3945},"1576850":{"node_type":"midmarker","x":1495,"y":3945},"1576851":{"node_type":"multimarker","x":1555,"y":3945},"1576852":{"node_type":"midmarker","x":1414,"y":3486},"1576853":{"node_type":"multimarker","x":1493,"y":3519},"1576854":{"node_type":"multimarker","x":1348,"y":3458},"1576855":{"node_type":"multimarker","x":1055,"y":3265},"1576856":{"node_type":"midmarker","x":1055,"y":3225},"1576857":{"node_type":"midmarker","x":1055,"y":1395},"1576858":{"node_type":"midmarker","x":3989,"y":4598},"1576859":{"node_type":"midmarker","x":835,"y":1715},"1576860":{"node_type":"multimarker","x":835,"y":1665},"1576861":{"node_type":"multimarker","x":835,"y":1765},"1576863":{"node_type":"midmarker","x":5025,"y":2880},"1576864":{"node_type":"multimarker","x":3417,"y":3766},"1576865":{"node_type":"midmarker","x":3417,"y":3857},"1576866":{"node_type":"midmarker","x":4145,"y":1260},"1576867":{"node_type":"multimarker","x":4145,"y":1200},"1576868":{"node_type":"midmarker","x":5020,"y":4158},"1576871":{"node_type":"midmarker","x":3621,"y":4914},"1576872":{"node_type":"midmarker","x":2178,"y":1995},"1576873":{"node_type":"multimarker","x":2175,"y":1955},"1576874":{"node_type":"multimarker","x":2178,"y":2035},"1576875":{"node_type":"multimarker","x":1055,"y":3655},"1576876":{"node_type":"midmarker","x":1055,"y":3705},"1576877":{"node_type":"multimarker","x":1055,"y":3745},"1576878":{"node_type":"midmarker","x":4645,"y":3635},"1576879":{"node_type":"multimarker","x":4541,"y":3635},"1576880":{"node_type":"multimarker","x":4779,"y":3635},"1576881":{"node_type":"midmarker","x":1055,"y":4925},"1576884":{"node_type":"midmarker","x":155,"y":3945},"1576885":{"node_type":"midmarker","x":2045,"y":1415},"1576887":{"node_type":"midmarker","x":4986,"y":2230},"1576888":{"node_type":"midmarker","x":3631,"y":3020},"1576889":{"node_type":"multimarker","x":3588,"y":2976},"1576890":{"node_type":"multimarker","x":3666,"y":3063},"1576891":{"node_type":"midmarker","x":1055,"y":1735},"1576892":{"node_type":"multimarker","x":1055,"y":1775},"1576893":{"node_type":"multimarker","x":1055,"y":1690},"1576895":{"node_type":"midmarker","x":5015,"y":3636},"1576896":{"node_type":"midmarker","x":1525,"y":1735},"1576897":{"node_type":"multimarker","x":1695,"y":1735},"1576898":{"node_type":"multimarker","x":1405,"y":1735},"1576899":{"node_type":"multimarker","x":4364,"y":3889},"1576900":{"node_type":"midmarker","x":4364,"y":3869},"1576901":{"node_type":"multimarker","x":4364,"y":3849},"1576905":{"node_type":"multimarker","x":3470,"y":1270},"1576906":{"node_type":"multimarker","x":3570,"y":1270},"1576907":{"node_type":"midmarker","x":3520,"y":1270},"1576908":{"node_type":"multimarker","x":3780,"y":3480},"1576909":{"node_type":"midmarker","x":3783,"y":3402},"1576910":{"node_type":"multimarker","x":3776,"y":3330},"1576911":{"node_type":"midmarker","x":1335,"y":3995},"1576912":{"node_type":"multimarker","x":1255,"y":3995},"1576913":{"node_type":"multimarker","x":1415,"y":3995},"1576914":{"node_type":"midmarker","x":4970,"y":1660},"1576916":{"node_type":"midmarker","x":1404,"y":3526},"1576917":{"node_type":"multimarker","x":1485,"y":3554},"1576918":{"node_type":"multimarker","x":1335,"y":3503},"1576919":{"node_type":"multimarker","x":2880,"y":4520},"1576920":{"node_type":"midmarker","x":2880,"y":4580},"1576921":{"node_type":"multimarker","x":2880,"y":4725},"1576922":{"node_type":"multimarker","x":4502,"y":3228},"1576923":{"node_type":"multimarker","x":4792,"y":3228},"1576924":{"node_type":"midmarker","x":4662,"y":3228},"1576925":{"node_type":"multimarker","x":1055,"y":2045},"1576926":{"node_type":"midmarker","x":1055,"y":1995},"1576927":{"node_type":"midmarker","x":955,"y":2195},"1576928":{"node_type":"midmarker","x":4660,"y":1900},"1576929":{"node_type":"multimarker","x":4690,"y":1900},"1576930":{"node_type":"multimarker","x":4630,"y":1900},"1576931":{"node_type":"midmarker","x":2305,"y":1425},"1576932":{"node_type":"multimarker","x":2843,"y":3341},"1576933":{"node_type":"multimarker","x":2994,"y":3445},"1576934":{"node_type":"midmarker","x":2911,"y":3388},"1576935":{"node_type":"multimarker","x":1715,"y":4065},"1576936":{"node_type":"multimarker","x":1715,"y":4105},"1576937":{"node_type":"midmarker","x":1715,"y":4085},"1576938":{"node_type":"multimarker","x":4415,"y":4158},"1576939":{"node_type":"midmarker","x":4435,"y":4158},"1576940":{"node_type":"multimarker","x":4455,"y":4158},"1576941":{"node_type":"multimarker","x":2310,"y":3330},"1576942":{"node_type":"midmarker","x":2250,"y":3360},"1576943":{"node_type":"multimarker","x":2190,"y":3390},"1576944":{"node_type":"multimarker","x":1327,"y":1265},"1576945":{"node_type":"midmarker","x":1307,"y":1265},"1576946":{"node_type":"multimarker","x":1287,"y":1265},"1576947":{"node_type":"midmarker","x":1715,"y":4935},"1576949":{"node_type":"multimarker","x":4247,"y":3815},"1576950":{"node_type":"multimarker","x":4247,"y":3877},"1576951":{"node_type":"midmarker","x":4247,"y":3857},"1576952":{"node_type":"multimarker","x":4215,"y":1200},"1576953":{"node_type":"midmarker","x":4215,"y":1260},"1576954":{"node_type":"multimarker","x":4215,"y":1350},"1576955":{"node_type":"multimarker","x":1055,"y":4125},"1576956":{"node_type":"multimarker","x":1055,"y":4225},"1576957":{"node_type":"midmarker","x":1055,"y":4175},"1576958":{"node_type":"multimarker","x":2578,"y":3456},"1576959":{"node_type":"midmarker","x":2577,"y":3404},"1576960":{"node_type":"multimarker","x":2582,"y":3341},"1576961":{"node_type":"midmarker","x":3257,"y":4614},"1576962":{"node_type":"midmarker","x":3257,"y":4924},"1576964":{"node_type":"multimarker","x":2175,"y":1645},"1576965":{"node_type":"midmarker","x":2175,"y":1695},"1576966":{"node_type":"multimarker","x":2175,"y":1735},"1576967":{"node_type":"midmarker","x":3621,"y":4604},"1576969":{"node_type":"midmarker","x":5032,"y":3228},"1576970":{"node_type":"multimarker","x":835,"y":3805},"1576971":{"node_type":"multimarker","x":835,"y":3525},"1576972":{"node_type":"midmarker","x":835,"y":3645},"1576974":{"node_type":"midmarker","x":1056.6529541015625,"y":543.4132690429688},"1576975":{"node_type":"multimarker","x":2500,"y":4430},"1576976":{"node_type":"midmarker","x":2500,"y":4550},"1576977":{"node_type":"multimarker","x":2500,"y":4730},"1576978":{"node_type":"midmarker","x":1055,"y":2995},"1576980":{"node_type":"midmarker","x":2500,"y":4937.93359375},"1576981":{"node_type":"multimarker","x":1715,"y":4305},"1576982":{"node_type":"midmarker","x":1715,"y":4275},"1576983":{"node_type":"multimarker","x":1715,"y":4255},"1576985":{"node_type":"midmarker","x":3991,"y":4918},"1576986":{"node_type":"multimarker","x":4116,"y":3888},"1576987":{"node_type":"multimarker","x":4116,"y":3848},"1576988":{"node_type":"midmarker","x":4116,"y":3868},"1576989":{"node_type":"midmarker","x":2880,"y":4925.107421875},"1576991":{"node_type":"multimarker","x":2840,"y":730},"1576992":{"node_type":"multimarker","x":2840,"y":980},"1576993":{"node_type":"midmarker","x":2840,"y":840},"1576994":{"node_type":"multimarker","x":1715,"y":4745},"1576995":{"node_type":"midmarker","x":1715,"y":4585},"1576996":{"node_type":"multimarker","x":1715,"y":4501.49560546875},"1576997":{"node_type":"midmarker","x":1056.5865478515625,"y":1008.8675537109375},"1576998":{"node_type":"multimarker","x":1057,"y":976.1735229492188},"1576999":{"node_type":"multimarker","x":1056.5867919921875,"y":1041.710205078125},"1577000":{"node_type":"midmarker","x":4667,"y":2846},"1577001":{"node_type":"multimarker","x":4770,"y":2846},"1577002":{"node_type":"multimarker","x":4560,"y":2846},"1577003":{"node_type":"midmarker","x":1637,"y":1265},"1577004":{"node_type":"multimarker","x":1657,"y":1265},"1577005":{"node_type":"multimarker","x":1617,"y":1265},"1577006":{"node_type":"multimarker","x":1055,"y":2345},"1577007":{"node_type":"multimarker","x":1055,"y":2435},"1577008":{"node_type":"midmarker","x":1055,"y":2395},"1577009":{"node_type":"midmarker","x":2840,"y":470},"1577011":{"node_type":"midmarker","x":4666,"y":3027},"1577012":{"node_type":"multimarker","x":4536,"y":3027},"1577013":{"node_type":"multimarker","x":4796,"y":3027},"1577014":{"node_type":"multimarker","x":4078,"y":3632},"1577015":{"node_type":"midmarker","x":4098,"y":3632},"1577016":{"node_type":"multimarker","x":4118,"y":3632},"1577017":{"node_type":"multimarker","x":4705,"y":1150},"1577018":{"node_type":"multimarker","x":4625,"y":1150},"1577019":{"node_type":"midmarker","x":4665,"y":1150},"1577020":{"node_type":"multimarker","x":2744,"y":3837},"1577021":{"node_type":"multimarker","x":2840,"y":3918},"1577022":{"node_type":"midmarker","x":2798,"y":3886},"1577023":{"node_type":"multimarker","x":375,"y":3945},"1577024":{"node_type":"multimarker","x":645,"y":3945},"1577025":{"node_type":"midmarker","x":505,"y":3945},"1577026":{"node_type":"midmarker","x":2260,"y":3390},"1577027":{"node_type":"multimarker","x":2220,"y":3410},"1577028":{"node_type":"multimarker","x":2310,"y":3360},"1577030":{"node_type":"midmarker","x":1460,"y":4925},"1577031":{"node_type":"multimarker","x":2040,"y":3945},"1577032":{"node_type":"midmarker","x":2010,"y":3945},"1577033":{"node_type":"multimarker","x":1980,"y":3945},"1577034":{"node_type":"midmarker","x":2210,"y":4570},"1577035":{"node_type":"midmarker","x":2211,"y":4944},"1577041":{"node_type":"multimarker","x":2371,"y":4100},"1577042":{"node_type":"midmarker","x":2356,"y":4086},"1577043":{"node_type":"multimarker","x":2342,"y":4071},"1577044":{"node_type":"multimarker","x":1360,"y":4730},"1577045":{"node_type":"midmarker","x":1360,"y":4600},"1577046":{"node_type":"multimarker","x":1360,"y":4470},"1577047":{"node_type":"midmarker","x":1460,"y":4432},"1577048":{"node_type":"multimarker","x":3080,"y":2600},"1577049":{"node_type":"midmarker","x":3110,"y":2600},"1577050":{"node_type":"multimarker","x":3140,"y":2600},"1577051":{"node_type":"multimarker","x":576.050048828125,"y":1361.5867919921875},"1577052":{"node_type":"midmarker","x":640,"y":1361.586669921875},"1577053":{"node_type":"multimarker","x":704.5778198242188,"y":1361.586669921875},"1577054":{"node_type":"midmarker","x":182,"y":1360},"1577056":{"node_type":"multimarker","x":2610,"y":736},"1577057":{"node_type":"midmarker","x":2610,"y":756},"1577058":{"node_type":"multimarker","x":2610,"y":980},"1577059":{"node_type":"midmarker","x":2610,"y":470},"1577061":{"node_type":"multimarker","x":4630,"y":2570},"1577062":{"node_type":"midmarker","x":4670,"y":2570},"1577063":{"node_type":"multimarker","x":4710,"y":2570},"1577064":{"node_type":"multimarker","x":3180,"y":2817},"1577065":{"node_type":"midmarker","x":3129,"y":2819},"1577066":{"node_type":"multimarker","x":3078,"y":2826},"1577067":{"node_type":"multimarker","x":1055,"y":4660.98193359375},"1577068":{"node_type":"midmarker","x":1055,"y":4583.8583984375},"1577069":{"node_type":"multimarker","x":1053.4132080078125,"y":4506.7353515625},"1577071":{"node_type":"metabolite","x":1095,"y":4750.98193359375,"bigg_id":"h_e","name":"H+","label_x":1125,"label_y":4760.98193359375,"node_is_primary":false},"1577072":{"node_type":"metabolite","x":1093.4132080078125,"y":4416.7353515625,"bigg_id":"h_c","name":"H+","label_x":1123.4132080078125,"label_y":4426.7353515625,"node_is_primary":false},"1577073":{"node_type":"metabolite","x":5527.4580078125,"y":4574.02490234375,"bigg_id":"h2o_c","name":"H2O","label_x":5539.50146484375,"label_y":4562.89990234375,"node_is_primary":false},"1577074":{"node_type":"multimarker","x":5334.0517578125,"y":4717.48193359375},"1577075":{"node_type":"midmarker","x":5334.0517578125,"y":4737.48193359375},"1577076":{"node_type":"multimarker","x":5334.0517578125,"y":4757.48193359375},"1577077":{"node_type":"metabolite","x":5503.33544921875,"y":4924.5068359375,"bigg_id":"adp_c","name":"ADP","label_x":5529.1103515625,"label_y":4931.337890625,"node_is_primary":false},"1577078":{"node_type":"metabolite","x":5534.521484375,"y":4651.92236328125,"bigg_id":"glu__L_c","name":"L-Glutamate","label_x":5555.015625,"label_y":4645.02197265625,"node_is_primary":false},"1577079":{"node_type":"metabolite","x":5512.26513671875,"y":4517.58447265625,"bigg_id":"g3p_c","name":"Glyceraldehyde 3-phosphate","label_x":5534.87109375,"label_y":4508.57177734375,"node_is_primary":false},"1577080":{"node_type":"metabolite","x":5437.546875,"y":4466.33544921875,"bigg_id":"e4p_c","name":"D-Erythrose 4-phosphate","label_x":5442.19677734375,"label_y":4450.9853515625,"node_is_primary":false},"1577081":{"node_type":"metabolite","x":5262.95361328125,"y":4994.3544921875,"bigg_id":"h_c","name":"H+","label_x":5204.56640625,"label_y":5025.4677734375,"node_is_primary":false},"1577082":{"node_type":"metabolite","x":5403.0185546875,"y":4418.7158203125,"bigg_id":"r5p_c","name":"Alpha-D-Ribose 5-phosphate","label_x":5390.7685546875,"label_y":4391.7470703125,"node_is_primary":false},"1577083":{"node_type":"metabolite","x":5183.9716796875,"y":4488.05615234375,"bigg_id":"atp_c","name":"ATP","label_x":5152.708984375,"label_y":4461.08740234375,"node_is_primary":false},"1577084":{"node_type":"metabolite","x":5087.0712890625,"y":4498.61865234375,"bigg_id":"f6p_c","name":"D-Fructose 6-phosphate","label_x":5052.6396484375,"label_y":4477.9873046875,"node_is_primary":false},"1577085":{"node_type":"metabolite","x":4988.05859375,"y":4509.18115234375,"bigg_id":"pyr_c","name":"Pyruvate","label_x":4962.07666015625,"label_y":4488.5498046875,"node_is_primary":false},"1577086":{"node_type":"metabolite","x":4893.27099609375,"y":4529.25048828125,"bigg_id":"nad_c","name":"Nicotinamide adenine dinucleotide","label_x":4860.95166015625,"label_y":4501.22509765625,"node_is_primary":false},"1577087":{"node_type":"metabolite","x":5208.85205078125,"y":4931.947265625,"bigg_id":"coa_c","name":"Coenzyme A","label_x":5175.48828125,"label_y":4975.3330078125,"node_is_primary":false},"1577088":{"node_type":"metabolite","x":4783.69580078125,"y":4544.03759765625,"bigg_id":"oaa_c","name":"Oxaloacetate","label_x":4770.38916015625,"label_y":4522.349609375,"node_is_primary":false},"1577089":{"node_type":"metabolite","x":4700.52734375,"y":4559.88134765625,"bigg_id":"g6p_c","name":"D-Glucose 6-phosphate","label_x":4679.8271484375,"label_y":4537.1376953125,"node_is_primary":false},"1577090":{"node_type":"metabolite","x":5134.0517578125,"y":4897.1259765625,"bigg_id":"nadh_c","name":"Nicotinamide adenine dinucleotide - reduced","label_x":5078.88623046875,"label_y":4936.322265625,"node_is_primary":false},"1577091":{"node_type":"metabolite","x":5481.046875,"y":4979.51025390625,"bigg_id":"akg_c","name":"2-Oxoglutarate","label_x":5497.31591796875,"label_y":5004.2978515625,"node_is_primary":false},"1577092":{"node_type":"metabolite","x":4601.51416015625,"y":4576.78173828125,"bigg_id":"accoa_c","name":"Acetyl-CoA","label_x":4556.52001953125,"label_y":4549.81298828125,"node_is_primary":false},"1577093":{"node_type":"metabolite","x":4508.83935546875,"y":4602.1318359375,"bigg_id":"3pg_c","name":"3-Phospho-D-glycerate","label_x":4459.6201171875,"label_y":4576.21923828125,"node_is_primary":false},"1577094":{"node_type":"metabolite","x":4414.0517578125,"y":4629.59423828125,"bigg_id":"pep_c","name":"Phosphoenolpyruvate","label_x":4379.6201171875,"label_y":4607.90673828125,"node_is_primary":false},"1577095":{"node_type":"metabolite","x":4332.9951171875,"y":4650.7197265625,"bigg_id":"gln__L_c","name":"L-Glutamine","label_x":4253.14453125,"label_y":4627.97607421875,"node_is_primary":false},"1577096":{"node_type":"metabolite","x":5028.71435546875,"y":4864.818359375,"bigg_id":"nadp_c","name":"Nicotinamide adenine dinucleotide phosphate","label_x":4968.08447265625,"label_y":4902.36181640625,"node_is_primary":false},"1577097":{"node_type":"metabolite","x":4267.78271484375,"y":4682.4072265625,"bigg_id":"nadph_c","name":"Nicotinamide adenine dinucleotide phosphate - reduced","label_x":4203.775390625,"label_y":4664.94482421875,"node_is_primary":false},"1577098":{"node_type":"metabolite","x":4933.43505859375,"y":4831.37548828125,"bigg_id":"pi_c","name":"Phosphate","label_x":4884.8583984375,"label_y":4859.1142578125,"node_is_primary":false},"1577099":{"node_type":"multimarker","x":3055.6239109998846,"y":4023.6457547875243},"1577100":{"node_type":"midmarker","x":3074.275683525833,"y":4030.8645761345497},"1577101":{"node_type":"multimarker","x":3092.9274560517806,"y":4038.0833974815746},"1577102":{"node_type":"metabolite","x":3188.1170476587818,"y":3976.144484067998,"bigg_id":"h2o_c","name":"H2O","label_x":3189.1795476587818,"label_y":3930.712355161748,"node_is_primary":false},"1577103":{"node_type":"metabolite","x":3197.4642088485407,"y":4053.2845721909744,"bigg_id":"acon_C_c","name":"Cis-Aconitate","label_x":3156.1556150985407,"label_y":4098.026271409724,"node_is_primary":true},"1577104":{"node_type":"multimarker","x":3294.488060371458,"y":4035.7165277261324},"1577105":{"node_type":"midmarker","x":3312.895717745038,"y":4027.896160086635},"1577106":{"node_type":"multimarker","x":3331.3033751186185,"y":4020.0757924471372}},"text_labels":{},"canvas":{"x":7.857062530517567,"y":314.36893920898433,"width":5894.515691375733,"height":4860.457037353515}}] \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/expected_single_knockout.csv Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,13016 @@ +reaction_id;ko_gene_id_1;ko_gene_id_2;reaction;wildtype_flux;knockout_flux +ACALD;b1241;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1241;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1241;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1241;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1241;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1241;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1241;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1241;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1241;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1241;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1241;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1241;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1241;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1241;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1241;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1241;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1241;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1241;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1241;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1241;;ac_e --> ;0.0;0.0 +EX_acald_e;b1241;;acald_e --> ;0.0;0.0 +EX_akg_e;b1241;;akg_e --> ;0.0;0.0 +EX_co2_e;b1241;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1241;;etoh_e --> ;0.0;0.0 +EX_for_e;b1241;;for_e --> ;0.0;0.0 +EX_fru_e;b1241;;fru_e --> ;0.0;0.0 +EX_fum_e;b1241;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1241;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1241;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1241;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1241;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1241;;h2o_e <=> ;29.175827135565836;29.175827135565825 +EX_lac__D_e;b1241;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1241;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1241;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1241;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1241;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1241;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1241;;succ_e --> ;0.0;0.0 +FBA;b1241;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1241;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1241;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1241;;for_c --> for_e;0.0;0.0 +FRD7;b1241;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1241;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1241;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1241;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1241;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1241;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1241;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1241;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1241;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1241;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1241;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1241;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1241;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1241;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1241;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825 +ICDHyr;b1241;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1241;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1241;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1241;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1241;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1241;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1241;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1241;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1241;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1241;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1241;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1241;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1241;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1241;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1241;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1241;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1241;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1241;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1241;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1241;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1241;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1241;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1241;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1241;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1241;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1241;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1241;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1241;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1241;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1241;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1241;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1241;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1241;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1241;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1241;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1241;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1241;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0351;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0351;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0351;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0351;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0351;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0351;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0351;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0351;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0351;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0351;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0351;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0351;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0351;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0351;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0351;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0351;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0351;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0351;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0351;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0351;;ac_e --> ;0.0;0.0 +EX_acald_e;b0351;;acald_e --> ;0.0;0.0 +EX_akg_e;b0351;;akg_e --> ;0.0;0.0 +EX_co2_e;b0351;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0351;;etoh_e --> ;0.0;0.0 +EX_for_e;b0351;;for_e --> ;0.0;0.0 +EX_fru_e;b0351;;fru_e --> ;0.0;0.0 +EX_fum_e;b0351;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0351;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0351;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0351;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0351;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0351;;h2o_e <=> ;29.175827135565836;29.175827135565825 +EX_lac__D_e;b0351;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0351;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0351;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0351;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0351;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0351;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0351;;succ_e --> ;0.0;0.0 +FBA;b0351;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0351;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0351;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0351;;for_c --> for_e;0.0;0.0 +FRD7;b0351;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0351;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0351;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0351;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0351;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0351;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0351;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0351;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0351;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0351;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0351;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0351;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0351;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0351;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0351;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825 +ICDHyr;b0351;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0351;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0351;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0351;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0351;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0351;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0351;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0351;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0351;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0351;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0351;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0351;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0351;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0351;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0351;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0351;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0351;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0351;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0351;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0351;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0351;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0351;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0351;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0351;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0351;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0351;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0351;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0351;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0351;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0351;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0351;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0351;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0351;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0351;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0351;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0351;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0351;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;s0001;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.472323479412339 +ACALDt;s0001;;acald_e --> acald_c;0.0;0.0 +ACKr;s0001;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.318655312470348 +ACONTa;s0001;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22779965006005928 +ACONTb;s0001;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.22779965006005928 +ACt2r;s0001;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.318655312470348 +ADK1;s0001;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;s0001;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;s0001;;akg_e + h_e <=> akg_c + h_c;0.0;-1.447703970271745e-14 +ALCD2x;s0001;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.472323479412339 +ATPM;s0001;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;s0001;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.30330124790922 +Biomass_Ecoli_core;s0001;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21114065257211634 +CO2t;s0001;;co2_e --> co2_c;-22.809833310205086;0.0 +CS;s0001;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22779965006005923 +CYTBD;s0001;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;-1.6547366278141024e-14 +D_LACt2;s0001;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;s0001;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.122858387019665 +ETOHt2r;s0001;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.472323479412339 +EX_ac_e;s0001;;ac_e --> ;0.0;8.318655312470348 +EX_acald_e;s0001;;acald_e --> ;0.0;0.0 +EX_akg_e;s0001;;akg_e --> ;0.0;0.0 +EX_co2_e;s0001;;co2_e <=> ;22.809833310205086;0.0 +EX_etoh_e;s0001;;etoh_e --> ;0.0;8.472323479412339 +EX_for_e;s0001;;for_e --> ;0.0;17.4328463757019 +EX_fru_e;s0001;;fru_e --> ;0.0;0.0 +EX_fum_e;s0001;;fum_e --> ;0.0;0.0 +EX_glc__D_e;s0001;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;s0001;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;s0001;;glu__L_e --> ;0.0;0.0 +EX_h_e;s0001;;h_e <=> ;17.530865429786523;29.98698317876892 +EX_h2o_e;s0001;;h2o_e <=> ;29.175827135565836;-6.934290509816053 +EX_lac__D_e;s0001;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;s0001;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;s0001;;nh4_e <=> ;-4.765319193197444;-1.1513077503452354 +EX_o2_e;s0001;;o2_e <=> ;-21.799492655998886;8.798875280606325e-15 +EX_pi_e;s0001;;pi_e <=> ;-3.214895047684769;-0.7767231186170603 +EX_pyr_e;s0001;;pyr_e --> ;0.0;0.0 +EX_succ_e;s0001;;succ_e --> ;0.0;1.536386688842234e-14 +FBA;s0001;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.78997839288652 +FBP;s0001;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;s0001;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;s0001;;for_c --> for_e;0.0;17.4328463757019 +FRD7;s0001;;fum_c + q8h2_c --> q8_c + succ_c;0.0;1.6547366278141024e-14 +FRUpts2;s0001;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;s0001;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-1.621620453890388e-14 +FUMt2_2;s0001;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;s0001;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;s0001;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.43872480326755 +GLCpts;s0001;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;s0001;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.05398866486269013 +GLNabc;s0001;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;s0001;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.0973190854825454 +GLUN;s0001;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;s0001;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;s0001;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;s0001;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;s0001;;h2o_e <=> h2o_c;-29.175827135565836;6.934290509815987 +ICDHyr;s0001;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22779965006005928 +ICL;s0001;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;s0001;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;s0001;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;s0001;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;s0001;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-1.84285999979242e-14 +ME1;s0001;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;s0001;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;s0001;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;s0001;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;s0001;;nh4_e <=> nh4_c;4.765319193197444;1.1513077503452356 +O2t;s0001;;o2_e --> o2_c;21.799492655998886;0.0 +PDH;s0001;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.37724500395062394 +PFK;s0001;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.78997839288652 +PFL;s0001;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.4328463757019 +PGI;s0001;;g6p_c <=> f6p_c;4.860861146496871;9.956716166222717 +PGK;s0001;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.438724803267554 +PGL;s0001;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;s0001;;2pg_c <=> 3pg_c;-14.716139568742859;-19.12285838701966 +PIt2r;s0001;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7767231186170603 +PPC;s0001;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6050446540106663 +PPCK;s0001;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;s0001;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;s0001;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.318655312470348 +PYK;s0001;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.408210620258805 +PYRt2;s0001;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;s0001;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.15176790106883897 +RPI;s0001;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15176790106883897 +SUCCt2_2;s0001;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;s0001;;h_e + succ_c --> h_c + succ_e;0.0;1.536386688842234e-14 +SUCDi;s0001;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;s0001;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;s0001;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.0377730627451524 +THD2;s0001;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6202387430667735 +TKT1;s0001;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.0377730627451524 +TKT2;s0001;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11399483832368643 +TPI;s0001;;dhap_c <=> g3p_c;7.477381962160304;9.78997839288652 +ACALD;b3115;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3115;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3115;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-4.912213865250822e-15 +ACONTa;b3115;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350328 +ACONTb;b3115;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350328 +ACt2r;b3115;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3115;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3115;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.06437566148209 +AKGt2r;b3115;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3115;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3115;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3115;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454 +Biomass_Ecoli_core;b3115;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3115;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020496 +CS;b3115;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350327 +CYTBD;b3115;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199751 +D_LACt2;b3115;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3115;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742829 +ETOHt2r;b3115;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3115;;ac_e --> ;0.0;0.0 +EX_acald_e;b3115;;acald_e --> ;0.0;0.0 +EX_akg_e;b3115;;akg_e --> ;0.0;0.0 +EX_co2_e;b3115;;co2_e <=> ;22.809833310205086;22.80983331020496 +EX_etoh_e;b3115;;etoh_e --> ;0.0;0.0 +EX_for_e;b3115;;for_e --> ;0.0;0.0 +EX_fru_e;b3115;;fru_e --> ;0.0;0.0 +EX_fum_e;b3115;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3115;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3115;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3115;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3115;;h_e <=> ;17.530865429786523;17.530865429786687 +EX_h2o_e;b3115;;h2o_e <=> ;29.175827135565836;29.175827135565772 +EX_lac__D_e;b3115;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3115;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3115;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3115;;o2_e <=> ;-21.799492655998886;-21.79949265599875 +EX_pi_e;b3115;;pi_e <=> ;-3.214895047684769;-3.214895047684754 +EX_pyr_e;b3115;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3115;;succ_e --> ;0.0;0.0 +FBA;b3115;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.4773819621602815 +FBP;b3115;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3115;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3115;;for_c --> for_e;0.0;0.0 +FRD7;b3115;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3115;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3115;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.06437566148209 +FUMt2_2;b3115;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3115;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574662 +GAPD;b3115;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.0235261431676 +GLCpts;b3115;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3115;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3115;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3115;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3115;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3115;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3115;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3115;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574661 +H2Ot;b3115;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565793 +ICDHyr;b3115;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350328 +ICL;b3115;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3115;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3115;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3115;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3115;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.0643756614820905 +ME1;b3115;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3115;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3115;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515414 +NADTRHD;b3115;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3115;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3115;;o2_e <=> o2_c;21.799492655998886;21.79949265599875 +PDH;b3115;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166615 +PFK;b3115;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160282 +PFL;b3115;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3115;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496811 +PGK;b3115;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167604 +PGL;b3115;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.9599849445746615 +PGM;b3115;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742829 +PIt2r;b3115;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684754 +PPC;b3115;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368732 +PPCK;b3115;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3115;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3115;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;4.912213865250822e-15 +PYK;b3115;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067857 +PYRt2;b3115;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3115;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507534 +RPI;b3115;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671286 +SUCCt2_2;b3115;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3115;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3115;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.06437566148209 +SUCOAS;b3115;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.06437566148209 +TALA;b3115;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615683 +THD2;b3115;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3115;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615683 +TKT2;b3115;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459644 +TPI;b3115;;dhap_c <=> g3p_c;7.477381962160304;7.4773819621602815 +ACALD;b1849;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1849;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1849;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1849;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1849;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1849;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1849;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1849;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1849;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1849;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1849;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1849;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1849;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1849;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1849;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1849;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1849;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1849;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1849;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1849;;ac_e --> ;0.0;0.0 +EX_acald_e;b1849;;acald_e --> ;0.0;0.0 +EX_akg_e;b1849;;akg_e --> ;0.0;0.0 +EX_co2_e;b1849;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1849;;etoh_e --> ;0.0;0.0 +EX_for_e;b1849;;for_e --> ;0.0;0.0 +EX_fru_e;b1849;;fru_e --> ;0.0;0.0 +EX_fum_e;b1849;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1849;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1849;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1849;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1849;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1849;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1849;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1849;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1849;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1849;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1849;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1849;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1849;;succ_e --> ;0.0;0.0 +FBA;b1849;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1849;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1849;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1849;;for_c --> for_e;0.0;0.0 +FRD7;b1849;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1849;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1849;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1849;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1849;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1849;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1849;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1849;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1849;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1849;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1849;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1849;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1849;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1849;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1849;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1849;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1849;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1849;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1849;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1849;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1849;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1849;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1849;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1849;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1849;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1849;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1849;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1849;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1849;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1849;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1849;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1849;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1849;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1849;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1849;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1849;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1849;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1849;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1849;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1849;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1849;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1849;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1849;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1849;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1849;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1849;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1849;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1849;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1849;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1849;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1849;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1849;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2296;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2296;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2296;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2296;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2296;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2296;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2296;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2296;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2296;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2296;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2296;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2296;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2296;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2296;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2296;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2296;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2296;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2296;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2296;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2296;;ac_e --> ;0.0;0.0 +EX_acald_e;b2296;;acald_e --> ;0.0;0.0 +EX_akg_e;b2296;;akg_e --> ;0.0;0.0 +EX_co2_e;b2296;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2296;;etoh_e --> ;0.0;0.0 +EX_for_e;b2296;;for_e --> ;0.0;0.0 +EX_fru_e;b2296;;fru_e --> ;0.0;0.0 +EX_fum_e;b2296;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2296;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2296;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2296;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2296;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2296;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2296;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2296;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2296;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2296;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2296;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2296;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2296;;succ_e --> ;0.0;0.0 +FBA;b2296;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2296;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2296;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2296;;for_c --> for_e;0.0;0.0 +FRD7;b2296;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2296;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2296;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2296;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2296;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2296;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2296;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2296;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2296;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2296;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2296;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2296;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2296;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2296;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2296;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2296;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2296;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2296;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2296;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2296;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2296;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2296;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2296;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2296;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2296;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2296;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2296;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2296;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2296;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2296;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2296;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2296;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2296;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2296;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2296;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2296;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2296;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2296;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2296;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2296;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2296;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2296;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2296;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2296;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2296;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2296;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2296;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2296;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2296;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2296;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2296;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2296;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1276;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1276;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1276;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1276;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1276;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1276;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1276;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1276;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1276;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1276;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1276;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1276;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1276;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1276;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1276;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1276;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1276;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1276;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1276;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1276;;ac_e --> ;0.0;0.0 +EX_acald_e;b1276;;acald_e --> ;0.0;0.0 +EX_akg_e;b1276;;akg_e --> ;0.0;0.0 +EX_co2_e;b1276;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1276;;etoh_e --> ;0.0;0.0 +EX_for_e;b1276;;for_e --> ;0.0;0.0 +EX_fru_e;b1276;;fru_e --> ;0.0;0.0 +EX_fum_e;b1276;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1276;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1276;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1276;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1276;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1276;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1276;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1276;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1276;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1276;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1276;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1276;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1276;;succ_e --> ;0.0;0.0 +FBA;b1276;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1276;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1276;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1276;;for_c --> for_e;0.0;0.0 +FRD7;b1276;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1276;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1276;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1276;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1276;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1276;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1276;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1276;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1276;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1276;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1276;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1276;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1276;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1276;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1276;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1276;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1276;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1276;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1276;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1276;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1276;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1276;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1276;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1276;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1276;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1276;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1276;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1276;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1276;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1276;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1276;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1276;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1276;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1276;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1276;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1276;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1276;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1276;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1276;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1276;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1276;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1276;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1276;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1276;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1276;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1276;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1276;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1276;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1276;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1276;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1276;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1276;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0118;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0118;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0118;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0118;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0118;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0118;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0118;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0118;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0118;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0118;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0118;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0118;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0118;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0118;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0118;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0118;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0118;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0118;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0118;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0118;;ac_e --> ;0.0;0.0 +EX_acald_e;b0118;;acald_e --> ;0.0;0.0 +EX_akg_e;b0118;;akg_e --> ;0.0;0.0 +EX_co2_e;b0118;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0118;;etoh_e --> ;0.0;0.0 +EX_for_e;b0118;;for_e --> ;0.0;0.0 +EX_fru_e;b0118;;fru_e --> ;0.0;0.0 +EX_fum_e;b0118;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0118;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0118;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0118;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0118;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0118;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0118;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0118;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0118;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0118;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0118;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0118;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0118;;succ_e --> ;0.0;0.0 +FBA;b0118;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0118;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0118;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0118;;for_c --> for_e;0.0;0.0 +FRD7;b0118;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0118;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0118;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0118;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0118;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0118;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0118;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0118;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0118;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0118;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0118;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0118;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0118;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0118;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0118;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0118;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0118;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0118;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0118;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0118;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0118;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0118;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0118;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0118;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0118;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0118;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0118;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0118;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0118;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0118;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0118;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0118;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0118;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0118;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0118;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0118;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0118;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0118;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0118;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0118;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0118;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0118;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0118;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0118;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0118;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0118;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0118;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0118;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0118;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0118;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0118;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0118;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0474;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0474;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0474;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0474;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0474;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0474;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0474;;amp_c + atp_c --> 2.0 adp_c;0.0;0.0 +AKGDH;b0474;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0474;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0474;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0474;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0474;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0474;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0474;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0474;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0474;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0474;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0474;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0474;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0474;;ac_e --> ;0.0;0.0 +EX_acald_e;b0474;;acald_e --> ;0.0;0.0 +EX_akg_e;b0474;;akg_e --> ;0.0;0.0 +EX_co2_e;b0474;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0474;;etoh_e --> ;0.0;0.0 +EX_for_e;b0474;;for_e --> ;0.0;0.0 +EX_fru_e;b0474;;fru_e --> ;0.0;0.0 +EX_fum_e;b0474;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0474;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0474;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0474;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0474;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0474;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0474;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0474;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0474;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0474;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0474;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0474;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0474;;succ_e --> ;0.0;0.0 +FBA;b0474;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0474;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0474;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0474;;for_c --> for_e;0.0;0.0 +FRD7;b0474;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0474;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0474;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0474;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0474;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0474;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0474;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0474;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0474;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0474;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0474;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0474;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0474;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0474;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0474;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0474;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0474;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0474;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0474;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0474;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0474;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0474;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0474;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0474;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0474;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0474;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0474;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0474;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0474;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0474;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0474;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0474;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0474;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0474;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0474;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0474;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0474;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0474;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0474;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0474;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0474;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0474;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0474;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0474;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0474;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0474;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0474;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0474;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0474;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0474;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0474;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0474;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0116;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0116;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0116;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0116;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;2.8478696059987096 +ACONTb;b0116;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;2.8478696059987096 +ACt2r;b0116;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0116;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0116;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0116;;akg_e + h_e <=> akg_c + h_c;0.0;-6.294365088138015e-16 +ALCD2x;b0116;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0116;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0116;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;46.68398285272691 +Biomass_Ecoli_core;b0116;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.7823510529477402 +CO2t;b0116;;co2_e <=> co2_c;-22.809833310205086;-18.92290382907288 +CS;b0116;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;2.847869605998709 +CYTBD;b0116;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.82061149072961 +D_LACt2;b0116;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0116;;2pg_c <=> h2o_c + pep_c;14.716139568742859;10.64423255393881 +ETOHt2r;b0116;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0116;;ac_e --> ;0.0;0.0 +EX_acald_e;b0116;;acald_e --> ;0.0;0.0 +EX_akg_e;b0116;;akg_e --> ;0.0;0.0 +EX_co2_e;b0116;;co2_e <=> ;22.809833310205086;18.92290382907288 +EX_etoh_e;b0116;;etoh_e --> ;0.0;0.0 +EX_for_e;b0116;;for_e --> ;0.0;7.783755937209625 +EX_fru_e;b0116;;fru_e --> ;0.0;0.0 +EX_fum_e;b0116;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0116;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0116;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0116;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0116;;h_e <=> ;17.530865429786523;23.477718059341314 +EX_h2o_e;b0116;;h2o_e <=> ;29.175827135565836;24.621861839165348 +EX_lac__D_e;b0116;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0116;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0116;;nh4_e <=> ;-4.765319193197444;-4.2660038215134355 +EX_o2_e;b0116;;o2_e <=> ;-21.799492655998886;-21.910305745364802 +EX_pi_e;b0116;;pi_e <=> ;-3.214895047684769;-2.8780348184788798 +EX_pyr_e;b0116;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0116;;succ_e --> ;0.0;0.0 +FBA;b0116;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;3.1161489408324865 +FBP;b0116;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0116;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0116;;for_c --> for_e;0.0;7.783755937209625 +FRD7;b0116;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0116;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0116;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;2.003791054973398 +FUMt2_2;b0116;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0116;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;18.3169394004012 +GAPD;b0116;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;11.81462972914863 +GLCpts;b0116;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0116;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20004716423873717 +GLNabc;b0116;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0116;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.0659566572746995 +GLUN;b0116;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0116;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0116;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0116;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;18.316939400401196 +H2Ot;b0116;;h2o_e <=> h2o_c;-29.175827135565836;-24.621861839165348 +ICDHyr;b0116;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8440785510253138 +ICL;b0116;;icit_c --> glx_c + succ_c;0.0;2.0037910549733957 +LDH_D;b0116;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0116;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;2.0037910549733957 +MALt2_2;b0116;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0116;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;4.007582109946793 +ME1;b0116;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0116;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0116;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;41.81682043575621 +NADTRHD;b0116;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;23.219609411855135 +NH4t;b0116;;nh4_e <=> nh4_c;4.765319193197444;4.2660038215134355 +O2t;b0116;;o2_e <=> o2_c;21.799492655998886;21.910305745364802 +PDH;b0116;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b0116;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;3.1161489408324865 +PFL;b0116;;coa_c + pyr_c --> accoa_c + for_c;0.0;7.783755937209624 +PGI;b0116;;g6p_c <=> f6p_c;4.860861146496871;-8.477321366255477 +PGK;b0116;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-11.814629729148631 +PGL;b0116;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;18.3169394004012 +PGM;b0116;;2pg_c <=> 3pg_c;-14.716139568742859;-10.64423255393881 +PIt2r;b0116;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.8780348184788798 +PPC;b0116;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.23811412235364124 +PPCK;b0116;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0116;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0116;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0116;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b0116;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0116;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;11.64893899674196 +RPI;b0116;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-6.668000403659239 +SUCCt2_2;b0116;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0116;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0116;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;2.003791054973398 +SUCOAS;b0116;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-2.275026620207604e-15 +TALA;b0116;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;5.965683863428047 +THD2;b0116;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0116;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;5.965683863428046 +TKT2;b0116;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;5.683255133313913 +TPI;b0116;;dhap_c <=> g3p_c;7.477381962160304;3.1161489408324865 +ACALD;b0726;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0726;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0726;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0726;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.83680762209076 +ACONTb;b0726;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.83680762209076 +ACt2r;b0726;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0726;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0726;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0726;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0726;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0726;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0726;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.42816442230027 +Biomass_Ecoli_core;b0726;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8583074080226888 +CO2t;b0726;;co2_e <=> co2_c;-22.809833310205086;-23.474299097890487 +CS;b0726;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.83680762209076 +CYTBD;b0726;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.964019806950915 +D_LACt2;b0726;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0726;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.390098435259256 +ETOHt2r;b0726;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0726;;ac_e --> ;0.0;0.0 +EX_acald_e;b0726;;acald_e --> ;0.0;0.0 +EX_akg_e;b0726;;akg_e --> ;0.0;0.0 +EX_co2_e;b0726;;co2_e <=> ;22.809833310205086;23.474299097890487 +EX_etoh_e;b0726;;etoh_e --> ;0.0;0.0 +EX_for_e;b0726;;for_e --> ;0.0;0.0 +EX_fru_e;b0726;;fru_e --> ;0.0;0.0 +EX_fum_e;b0726;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0726;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0726;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0726;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0726;;h_e <=> ;17.530865429786523;17.21764660493515 +EX_h2o_e;b0726;;h2o_e <=> ;29.175827135565836;29.72655358089095 +EX_lac__D_e;b0726;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0726;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0726;;nh4_e <=> ;-4.765319193197444;-4.680178634466116 +EX_o2_e;b0726;;o2_e <=> ;-21.799492655998886;-22.482009903475454 +EX_pi_e;b0726;;pi_e <=> ;-3.214895047684769;-3.1574554618930675 +EX_pyr_e;b0726;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0726;;succ_e --> ;0.0;0.0 +FBA;b0726;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.102006521647742 +FBP;b0726;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0726;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0726;;for_c --> for_e;0.0;0.0 +FRD7;b0726;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0726;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0726;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.910779759575083 +FUMt2_2;b0726;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0726;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.132705298776269 +GAPD;b0726;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.674126317661198 +GLCpts;b0726;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0726;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21946920423140148 +GLNabc;b0726;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0726;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.460709430234715 +GLUN;b0726;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0726;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0726;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0726;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.132705298776268 +H2Ot;b0726;;h2o_e <=> h2o_c;-29.175827135565836;-29.72655358089095 +ICDHyr;b0726;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9260278625156778 +ICL;b0726;;icit_c --> glx_c + succ_c;0.0;4.910779759575083 +LDH_D;b0726;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0726;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;4.910779759575083 +MALt2_2;b0726;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0726;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.3703454680048965 +ME1;b0726;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0726;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;2.451214051145268 +NADH16;b0726;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.05324004737582 +NADTRHD;b0726;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0726;;nh4_e <=> nh4_c;4.765319193197444;4.680178634466117 +O2t;b0726;;o2_e <=> o2_c;21.799492655998886;22.482009903475454 +PDH;b0726;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;13.964351885453276 +PFK;b0726;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.102006521647743 +PFL;b0726;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0726;;g6p_c <=> f6p_c;4.860861146496871;3.6913416825790755 +PGK;b0726;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.674126317661202 +PGL;b0726;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.132705298776269 +PGM;b0726;;2pg_c <=> 3pg_c;-14.716139568742859;-14.390098435259256 +PIt2r;b0726;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1574554618930675 +PPC;b0726;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0 +PPCK;b0726;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0726;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0726;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0726;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.9445510597546773 +PYRt2;b0726;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0726;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.4715188342974694 +RPI;b0726;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.6611864644787984 +SUCCt2_2;b0726;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0726;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0726;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.910779759575083 +SUCOAS;b0726;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b0726;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.8906839042968304 +THD2;b0726;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0726;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.89068390429683 +TKT2;b0726;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.5808349300006397 +TPI;b0726;;dhap_c <=> g3p_c;7.477381962160304;7.102006521647742 +ACALD;b0727;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0727;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0727;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0727;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.836807622090764 +ACONTb;b0727;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.836807622090764 +ACt2r;b0727;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0727;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0727;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0727;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0727;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0727;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0727;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.42816442230032 +Biomass_Ecoli_core;b0727;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.858307408022689 +CO2t;b0727;;co2_e <=> co2_c;-22.809833310205086;-23.4742990978905 +CS;b0727;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.836807622090764 +CYTBD;b0727;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.964019806950944 +D_LACt2;b0727;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0727;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.390098435259251 +ETOHt2r;b0727;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0727;;ac_e --> ;0.0;0.0 +EX_acald_e;b0727;;acald_e --> ;0.0;0.0 +EX_akg_e;b0727;;akg_e --> ;0.0;0.0 +EX_co2_e;b0727;;co2_e <=> ;22.809833310205086;23.4742990978905 +EX_etoh_e;b0727;;etoh_e --> ;0.0;0.0 +EX_for_e;b0727;;for_e --> ;0.0;0.0 +EX_fru_e;b0727;;fru_e --> ;0.0;0.0 +EX_fum_e;b0727;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0727;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0727;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0727;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0727;;h_e <=> ;17.530865429786523;17.217646604935073 +EX_h2o_e;b0727;;h2o_e <=> ;29.175827135565836;29.726553580890982 +EX_lac__D_e;b0727;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0727;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0727;;nh4_e <=> ;-4.765319193197444;-4.680178634466118 +EX_o2_e;b0727;;o2_e <=> ;-21.799492655998886;-22.48200990347547 +EX_pi_e;b0727;;pi_e <=> ;-3.214895047684769;-3.1574554618930946 +EX_pyr_e;b0727;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0727;;succ_e --> ;0.0;0.0 +FBA;b0727;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.1020065216477395 +FBP;b0727;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0727;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0727;;for_c --> for_e;0.0;0.0 +FRD7;b0727;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0727;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0727;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.910779759575085 +FUMt2_2;b0727;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0727;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.132705298776282 +GAPD;b0727;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.674126317661196 +GLCpts;b0727;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0727;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21946920423140157 +GLNabc;b0727;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0727;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.460709430234716 +GLUN;b0727;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0727;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0727;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0727;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.132705298776281 +H2Ot;b0727;;h2o_e <=> h2o_c;-29.175827135565836;-29.726553580890982 +ICDHyr;b0727;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9260278625156771 +ICL;b0727;;icit_c --> glx_c + succ_c;0.0;4.910779759575085 +LDH_D;b0727;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0727;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;4.910779759575085 +MALt2_2;b0727;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0727;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.370345468004903 +ME1;b0727;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0727;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;2.4512140511452674 +NADH16;b0727;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.05324004737586 +NADTRHD;b0727;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0727;;nh4_e <=> nh4_c;4.765319193197444;4.680178634466118 +O2t;b0727;;o2_e <=> o2_c;21.799492655998886;22.48200990347547 +PDH;b0727;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;13.964351885453283 +PFK;b0727;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.1020065216477395 +PFL;b0727;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0727;;g6p_c <=> f6p_c;4.860861146496871;3.6913416825790697 +PGK;b0727;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.674126317661198 +PGL;b0727;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.1327052987762825 +PGM;b0727;;2pg_c <=> 3pg_c;-14.716139568742859;-14.390098435259251 +PIt2r;b0727;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1574554618930946 +PPC;b0727;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0 +PPCK;b0727;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0727;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0727;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0727;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.9445510597546733 +PYRt2;b0727;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0727;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.4715188342974783 +RPI;b0727;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.6611864644788032 +SUCCt2_2;b0727;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0727;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0727;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.910779759575085 +SUCOAS;b0727;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b0727;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.8906839042968346 +THD2;b0727;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0727;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.8906839042968344 +TKT2;b0727;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.580834930000644 +TPI;b0727;;dhap_c <=> g3p_c;7.477381962160304;7.1020065216477395 +ACALD;b2587;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2587;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2587;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2587;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350335 +ACONTb;b2587;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350335 +ACt2r;b2587;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2587;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2587;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.0643756614820985 +AKGt2r;b2587;;akg_e + h_e --> akg_c + h_c;0.0;0.0 +ALCD2x;b2587;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2587;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2587;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451749 +Biomass_Ecoli_core;b2587;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2587;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020498 +CS;b2587;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350334 +CYTBD;b2587;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754 +D_LACt2;b2587;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2587;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742832 +ETOHt2r;b2587;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2587;;ac_e --> ;0.0;0.0 +EX_acald_e;b2587;;acald_e --> ;0.0;0.0 +EX_akg_e;b2587;;akg_e --> ;0.0;0.0 +EX_co2_e;b2587;;co2_e <=> ;22.809833310205086;22.80983331020498 +EX_etoh_e;b2587;;etoh_e --> ;0.0;0.0 +EX_for_e;b2587;;for_e --> ;0.0;0.0 +EX_fru_e;b2587;;fru_e --> ;0.0;0.0 +EX_fum_e;b2587;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2587;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2587;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2587;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2587;;h_e <=> ;17.530865429786523;17.53086542978658 +EX_h2o_e;b2587;;h2o_e <=> ;29.175827135565836;29.17582713556585 +EX_lac__D_e;b2587;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2587;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2587;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2587;;o2_e <=> ;-21.799492655998886;-21.799492655998765 +EX_pi_e;b2587;;pi_e <=> ;-3.214895047684769;-3.2148950476847955 +EX_pyr_e;b2587;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2587;;succ_e --> ;0.0;0.0 +FBA;b2587;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160283 +FBP;b2587;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2587;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2587;;for_c --> for_e;0.0;0.0 +FRD7;b2587;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2587;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2587;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.0643756614820985 +FUMt2_2;b2587;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2587;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.95998494457466 +GAPD;b2587;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604 +GLCpts;b2587;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2587;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2587;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2587;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2587;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2587;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2587;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2587;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574659 +H2Ot;b2587;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556585 +ICDHyr;b2587;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2587;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2587;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2587;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2587;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2587;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482099 +ME1;b2587;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2587;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2587;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2587;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2587;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2587;;o2_e <=> o2_c;21.799492655998886;21.799492655998765 +PDH;b2587;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166618 +PFK;b2587;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160284 +PFL;b2587;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2587;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496814 +PGK;b2587;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608 +PGL;b2587;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574659 +PGM;b2587;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742832 +PIt2r;b2587;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847955 +PPC;b2587;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687308 +PPCK;b2587;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2587;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2587;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2587;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.758177444106788 +PYRt2;b2587;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2587;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507531 +RPI;b2587;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671277 +SUCCt2_2;b2587;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2587;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2587;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.0643756614820985 +SUCOAS;b2587;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.0643756614820985 +TALA;b2587;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615674 +THD2;b2587;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2587;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615672 +TKT2;b2587;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245964 +TPI;b2587;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160283 +ACALD;b0356;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0356;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0356;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0356;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0356;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0356;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0356;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0356;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0356;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0356;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0356;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0356;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0356;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0356;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0356;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0356;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0356;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0356;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0356;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0356;;ac_e --> ;0.0;0.0 +EX_acald_e;b0356;;acald_e --> ;0.0;0.0 +EX_akg_e;b0356;;akg_e --> ;0.0;0.0 +EX_co2_e;b0356;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0356;;etoh_e --> ;0.0;0.0 +EX_for_e;b0356;;for_e --> ;0.0;0.0 +EX_fru_e;b0356;;fru_e --> ;0.0;0.0 +EX_fum_e;b0356;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0356;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0356;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0356;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0356;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0356;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0356;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0356;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0356;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0356;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0356;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0356;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0356;;succ_e --> ;0.0;0.0 +FBA;b0356;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0356;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0356;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0356;;for_c --> for_e;0.0;0.0 +FRD7;b0356;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0356;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0356;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0356;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0356;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0356;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0356;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0356;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0356;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0356;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0356;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0356;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0356;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0356;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0356;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0356;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0356;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0356;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0356;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0356;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0356;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0356;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0356;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0356;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0356;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0356;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0356;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0356;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0356;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0356;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0356;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0356;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0356;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0356;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0356;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0356;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0356;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0356;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0356;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0356;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0356;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0356;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0356;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0356;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0356;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0356;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0356;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0356;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0356;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0356;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0356;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0356;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1478;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1478;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1478;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1478;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1478;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1478;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1478;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1478;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1478;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1478;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1478;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1478;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1478;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1478;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1478;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1478;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1478;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1478;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1478;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1478;;ac_e --> ;0.0;0.0 +EX_acald_e;b1478;;acald_e --> ;0.0;0.0 +EX_akg_e;b1478;;akg_e --> ;0.0;0.0 +EX_co2_e;b1478;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1478;;etoh_e --> ;0.0;0.0 +EX_for_e;b1478;;for_e --> ;0.0;0.0 +EX_fru_e;b1478;;fru_e --> ;0.0;0.0 +EX_fum_e;b1478;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1478;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1478;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1478;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1478;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1478;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1478;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1478;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1478;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1478;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1478;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1478;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1478;;succ_e --> ;0.0;0.0 +FBA;b1478;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1478;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1478;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1478;;for_c --> for_e;0.0;0.0 +FRD7;b1478;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1478;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1478;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1478;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1478;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1478;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1478;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1478;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1478;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1478;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1478;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1478;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1478;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1478;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1478;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1478;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1478;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1478;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1478;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1478;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1478;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1478;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1478;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1478;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1478;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1478;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1478;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1478;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1478;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1478;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1478;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1478;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1478;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1478;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1478;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1478;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1478;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1478;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1478;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1478;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1478;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1478;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1478;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1478;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1478;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1478;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1478;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1478;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1478;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1478;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1478;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1478;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3735;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-7.867597117252571e-16 +ACALDt;b3735;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3735;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829135 +ACONTa;b3735;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653205 +ACONTb;b3735;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.40375661206532054 +ACt2r;b3735;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829135 +ADK1;b3735;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3735;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b3735;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3735;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-7.867597117252571e-16 +ATPM;b3735;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3735;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0 +Biomass_Ecoli_core;b3735;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.374229874933111 +CO2t;b3735;;co2_e <=> co2_c;-22.809833310205086;0.0 +CS;b3735;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.40375661206532043 +CYTBD;b3735;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.58463174880539 +D_LACt2;b3735;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;-8.825244427412039e-15 +ENO;b3735;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565378 +ETOHt2r;b3735;;etoh_e + h_e <=> etoh_c + h_c;0.0;-7.867597117252571e-16 +EX_ac_e;b3735;;ac_e --> ;0.0;14.312267245829135 +EX_acald_e;b3735;;acald_e --> ;0.0;0.0 +EX_akg_e;b3735;;akg_e --> ;0.0;0.0 +EX_co2_e;b3735;;co2_e <=> ;22.809833310205086;0.0 +EX_etoh_e;b3735;;etoh_e --> ;0.0;0.0 +EX_for_e;b3735;;for_e --> ;0.0;15.44992606562574 +EX_fru_e;b3735;;fru_e --> ;0.0;0.0 +EX_fum_e;b3735;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3735;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3735;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3735;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3735;;h_e <=> ;17.530865429786523;37.269244602613135 +EX_h2o_e;b3735;;h2o_e <=> ;29.175827135565836;2.72604010096266 +EX_lac__D_e;b3735;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3735;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3735;;nh4_e <=> ;-4.765319193197444;-2.040600662035267 +EX_o2_e;b3735;;o2_e <=> ;-21.799492655998886;-7.292315874402702 +EX_pi_e;b3735;;pi_e <=> ;-3.214895047684769;-1.37667944091645 +EX_pyr_e;b3735;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3735;;succ_e --> ;0.0;0.0 +FBA;b3735;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037 +FBP;b3735;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3735;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3735;;for_c --> for_e;0.0;15.44992606562574 +FRD7;b3735;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3735;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3735;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-2.586245375694104e-14 +FUMt2_2;b3735;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3735;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b3735;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316 +GLCpts;b3735;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3735;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039647 +GLNabc;b3735;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3735;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.9449100830148707 +GLUN;b3735;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3735;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3735;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3735;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b3735;;h2o_e <=> h2o_c;-29.175827135565836;-2.72604010096266 +ICDHyr;b3735;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.40375661206532054 +ICL;b3735;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3735;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3735;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3735;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3735;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-2.4714245655065478e-14 +ME1;b3735;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3735;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3735;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805416 +NADTRHD;b3735;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3735;;nh4_e <=> nh4_c;4.765319193197444;2.040600662035267 +O2t;b3735;;o2_e <=> o2_c;21.799492655998886;7.292315874402694 +PDH;b3735;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175430308 +PFK;b3735;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037 +PFL;b3735;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.449926065625737 +PGI;b3735;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714 +PGK;b3735;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.005184723465316 +PGL;b3735;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b3735;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565378 +PIt2r;b3735;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.37667944091645 +PPC;b3735;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.0723931296083171 +PPCK;b3735;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3735;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3735;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829137 +PYK;b3735;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.178680972879282 +PYRt2;b3735;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3735;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.268996434101926 +RPI;b3735;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.268996434101926 +SUCCt2_2;b3735;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.918778743048437 +SUCCt3;b3735;;h_e + succ_c --> h_c + succ_e;0.0;11.918778743048437 +SUCDi;b3735;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;-2.8522595376073667e-14 +SUCOAS;b3735;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;1.8200212961660833e-14 +TALA;b3735;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553657 +THD2;b3735;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590636 +TKT1;b3735;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553656 +TKT2;b3735;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638942 +TPI;b3735;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037 +ACALD;b3733;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3733;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3733;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123 +ACONTa;b3733;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314 +ACONTb;b3733;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315 +ACt2r;b3733;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124 +ADK1;b3733;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3733;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b3733;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3733;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3733;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3733;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0 +Biomass_Ecoli_core;b3733;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097 +CO2t;b3733;;co2_e <=> co2_c;-22.809833310205086;0.0 +CS;b3733;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314 +CYTBD;b3733;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457 +D_LACt2;b3733;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3733;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385 +ETOHt2r;b3733;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3733;;ac_e --> ;0.0;14.312267245829124 +EX_acald_e;b3733;;acald_e --> ;0.0;0.0 +EX_akg_e;b3733;;akg_e --> ;0.0;0.0 +EX_co2_e;b3733;;co2_e <=> ;22.809833310205086;0.0 +EX_etoh_e;b3733;;etoh_e --> ;0.0;0.0 +EX_for_e;b3733;;for_e --> ;0.0;15.44992606562578 +EX_fru_e;b3733;;fru_e --> ;0.0;0.0 +EX_fum_e;b3733;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3733;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3733;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3733;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3733;;h_e <=> ;17.530865429786523;37.26924460261309 +EX_h2o_e;b3733;;h2o_e <=> ;29.175827135565836;2.726040100962767 +EX_lac__D_e;b3733;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3733;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3733;;nh4_e <=> ;-4.765319193197444;-2.04060066203526 +EX_o2_e;b3733;;o2_e <=> ;-21.799492655998886;-7.292315874402727 +EX_pi_e;b3733;;pi_e <=> ;-3.214895047684769;-1.3766794409164365 +EX_pyr_e;b3733;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3733;;succ_e --> ;0.0;0.0 +FBA;b3733;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037 +FBP;b3733;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3733;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3733;;for_c --> for_e;0.0;15.44992606562578 +FRD7;b3733;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3733;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3733;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b3733;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3733;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b3733;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316 +GLCpts;b3733;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3733;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614 +GLNabc;b3733;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3733;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864 +GLUN;b3733;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3733;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3733;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3733;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b3733;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767 +ICDHyr;b3733;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315 +ICL;b3733;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3733;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3733;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3733;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3733;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b3733;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3733;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3733;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455 +NADTRHD;b3733;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3733;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526 +O2t;b3733;;o2_e <=> o2_c;21.799492655998886;7.292315874402727 +PDH;b3733;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876 +PFK;b3733;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037 +PFL;b3733;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578 +PGI;b3733;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714 +PGK;b3733;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532 +PGL;b3733;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b3733;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385 +PIt2r;b3733;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365 +PPC;b3733;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319 +PPCK;b3733;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3733;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3733;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123 +PYK;b3733;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855 +PYRt2;b3733;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3733;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193 +RPI;b3733;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926 +SUCCt2_2;b3733;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856 +SUCCt3;b3733;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856 +SUCDi;b3733;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b3733;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b3733;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335 +THD2;b3733;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592 +TKT1;b3733;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334 +TKT2;b3733;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592 +TPI;b3733;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037 +ACALD;b3734;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3734;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3734;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123 +ACONTa;b3734;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314 +ACONTb;b3734;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315 +ACt2r;b3734;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124 +ADK1;b3734;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3734;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b3734;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3734;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3734;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3734;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0 +Biomass_Ecoli_core;b3734;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097 +CO2t;b3734;;co2_e <=> co2_c;-22.809833310205086;0.0 +CS;b3734;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314 +CYTBD;b3734;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457 +D_LACt2;b3734;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3734;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385 +ETOHt2r;b3734;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3734;;ac_e --> ;0.0;14.312267245829124 +EX_acald_e;b3734;;acald_e --> ;0.0;0.0 +EX_akg_e;b3734;;akg_e --> ;0.0;0.0 +EX_co2_e;b3734;;co2_e <=> ;22.809833310205086;0.0 +EX_etoh_e;b3734;;etoh_e --> ;0.0;0.0 +EX_for_e;b3734;;for_e --> ;0.0;15.44992606562578 +EX_fru_e;b3734;;fru_e --> ;0.0;0.0 +EX_fum_e;b3734;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3734;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3734;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3734;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3734;;h_e <=> ;17.530865429786523;37.26924460261309 +EX_h2o_e;b3734;;h2o_e <=> ;29.175827135565836;2.726040100962767 +EX_lac__D_e;b3734;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3734;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3734;;nh4_e <=> ;-4.765319193197444;-2.04060066203526 +EX_o2_e;b3734;;o2_e <=> ;-21.799492655998886;-7.292315874402727 +EX_pi_e;b3734;;pi_e <=> ;-3.214895047684769;-1.3766794409164365 +EX_pyr_e;b3734;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3734;;succ_e --> ;0.0;0.0 +FBA;b3734;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037 +FBP;b3734;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3734;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3734;;for_c --> for_e;0.0;15.44992606562578 +FRD7;b3734;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3734;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3734;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b3734;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3734;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b3734;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316 +GLCpts;b3734;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3734;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614 +GLNabc;b3734;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3734;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864 +GLUN;b3734;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3734;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3734;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3734;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b3734;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767 +ICDHyr;b3734;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315 +ICL;b3734;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3734;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3734;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3734;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3734;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b3734;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3734;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3734;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455 +NADTRHD;b3734;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3734;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526 +O2t;b3734;;o2_e <=> o2_c;21.799492655998886;7.292315874402727 +PDH;b3734;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876 +PFK;b3734;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037 +PFL;b3734;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578 +PGI;b3734;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714 +PGK;b3734;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532 +PGL;b3734;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b3734;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385 +PIt2r;b3734;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365 +PPC;b3734;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319 +PPCK;b3734;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3734;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3734;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123 +PYK;b3734;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855 +PYRt2;b3734;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3734;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193 +RPI;b3734;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926 +SUCCt2_2;b3734;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856 +SUCCt3;b3734;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856 +SUCDi;b3734;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b3734;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b3734;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335 +THD2;b3734;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592 +TKT1;b3734;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334 +TKT2;b3734;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592 +TPI;b3734;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037 +ACALD;b3732;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3732;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3732;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123 +ACONTa;b3732;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314 +ACONTb;b3732;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315 +ACt2r;b3732;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124 +ADK1;b3732;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3732;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b3732;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3732;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3732;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3732;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0 +Biomass_Ecoli_core;b3732;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097 +CO2t;b3732;;co2_e <=> co2_c;-22.809833310205086;0.0 +CS;b3732;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314 +CYTBD;b3732;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457 +D_LACt2;b3732;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3732;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385 +ETOHt2r;b3732;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3732;;ac_e --> ;0.0;14.312267245829124 +EX_acald_e;b3732;;acald_e --> ;0.0;0.0 +EX_akg_e;b3732;;akg_e --> ;0.0;0.0 +EX_co2_e;b3732;;co2_e <=> ;22.809833310205086;0.0 +EX_etoh_e;b3732;;etoh_e --> ;0.0;0.0 +EX_for_e;b3732;;for_e --> ;0.0;15.44992606562578 +EX_fru_e;b3732;;fru_e --> ;0.0;0.0 +EX_fum_e;b3732;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3732;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3732;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3732;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3732;;h_e <=> ;17.530865429786523;37.26924460261309 +EX_h2o_e;b3732;;h2o_e <=> ;29.175827135565836;2.726040100962767 +EX_lac__D_e;b3732;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3732;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3732;;nh4_e <=> ;-4.765319193197444;-2.04060066203526 +EX_o2_e;b3732;;o2_e <=> ;-21.799492655998886;-7.292315874402727 +EX_pi_e;b3732;;pi_e <=> ;-3.214895047684769;-1.3766794409164365 +EX_pyr_e;b3732;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3732;;succ_e --> ;0.0;0.0 +FBA;b3732;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037 +FBP;b3732;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3732;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3732;;for_c --> for_e;0.0;15.44992606562578 +FRD7;b3732;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3732;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3732;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b3732;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3732;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b3732;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316 +GLCpts;b3732;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3732;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614 +GLNabc;b3732;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3732;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864 +GLUN;b3732;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3732;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3732;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3732;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b3732;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767 +ICDHyr;b3732;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315 +ICL;b3732;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3732;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3732;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3732;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3732;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b3732;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3732;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3732;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455 +NADTRHD;b3732;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3732;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526 +O2t;b3732;;o2_e <=> o2_c;21.799492655998886;7.292315874402727 +PDH;b3732;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876 +PFK;b3732;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037 +PFL;b3732;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578 +PGI;b3732;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714 +PGK;b3732;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532 +PGL;b3732;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b3732;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385 +PIt2r;b3732;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365 +PPC;b3732;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319 +PPCK;b3732;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3732;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3732;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123 +PYK;b3732;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855 +PYRt2;b3732;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3732;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193 +RPI;b3732;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926 +SUCCt2_2;b3732;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856 +SUCCt3;b3732;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856 +SUCDi;b3732;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b3732;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b3732;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335 +THD2;b3732;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592 +TKT1;b3732;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334 +TKT2;b3732;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592 +TPI;b3732;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037 +ACALD;b3736;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3736;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3736;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123 +ACONTa;b3736;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314 +ACONTb;b3736;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315 +ACt2r;b3736;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124 +ADK1;b3736;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3736;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b3736;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3736;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3736;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3736;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0 +Biomass_Ecoli_core;b3736;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097 +CO2t;b3736;;co2_e <=> co2_c;-22.809833310205086;0.0 +CS;b3736;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314 +CYTBD;b3736;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457 +D_LACt2;b3736;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3736;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385 +ETOHt2r;b3736;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3736;;ac_e --> ;0.0;14.312267245829124 +EX_acald_e;b3736;;acald_e --> ;0.0;0.0 +EX_akg_e;b3736;;akg_e --> ;0.0;0.0 +EX_co2_e;b3736;;co2_e <=> ;22.809833310205086;0.0 +EX_etoh_e;b3736;;etoh_e --> ;0.0;0.0 +EX_for_e;b3736;;for_e --> ;0.0;15.44992606562578 +EX_fru_e;b3736;;fru_e --> ;0.0;0.0 +EX_fum_e;b3736;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3736;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3736;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3736;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3736;;h_e <=> ;17.530865429786523;37.26924460261309 +EX_h2o_e;b3736;;h2o_e <=> ;29.175827135565836;2.726040100962767 +EX_lac__D_e;b3736;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3736;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3736;;nh4_e <=> ;-4.765319193197444;-2.04060066203526 +EX_o2_e;b3736;;o2_e <=> ;-21.799492655998886;-7.292315874402727 +EX_pi_e;b3736;;pi_e <=> ;-3.214895047684769;-1.3766794409164365 +EX_pyr_e;b3736;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3736;;succ_e --> ;0.0;0.0 +FBA;b3736;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037 +FBP;b3736;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3736;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3736;;for_c --> for_e;0.0;15.44992606562578 +FRD7;b3736;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3736;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3736;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b3736;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3736;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b3736;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316 +GLCpts;b3736;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3736;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614 +GLNabc;b3736;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3736;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864 +GLUN;b3736;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3736;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3736;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3736;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b3736;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767 +ICDHyr;b3736;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315 +ICL;b3736;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3736;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3736;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3736;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3736;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b3736;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3736;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3736;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455 +NADTRHD;b3736;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3736;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526 +O2t;b3736;;o2_e <=> o2_c;21.799492655998886;7.292315874402727 +PDH;b3736;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876 +PFK;b3736;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037 +PFL;b3736;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578 +PGI;b3736;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714 +PGK;b3736;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532 +PGL;b3736;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b3736;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385 +PIt2r;b3736;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365 +PPC;b3736;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319 +PPCK;b3736;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3736;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3736;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123 +PYK;b3736;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855 +PYRt2;b3736;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3736;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193 +RPI;b3736;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926 +SUCCt2_2;b3736;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856 +SUCCt3;b3736;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856 +SUCDi;b3736;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b3736;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b3736;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335 +THD2;b3736;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592 +TKT1;b3736;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334 +TKT2;b3736;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592 +TPI;b3736;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037 +ACALD;b3738;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3738;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3738;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123 +ACONTa;b3738;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314 +ACONTb;b3738;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315 +ACt2r;b3738;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124 +ADK1;b3738;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3738;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b3738;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3738;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3738;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3738;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0 +Biomass_Ecoli_core;b3738;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097 +CO2t;b3738;;co2_e <=> co2_c;-22.809833310205086;0.0 +CS;b3738;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314 +CYTBD;b3738;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457 +D_LACt2;b3738;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3738;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385 +ETOHt2r;b3738;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3738;;ac_e --> ;0.0;14.312267245829124 +EX_acald_e;b3738;;acald_e --> ;0.0;0.0 +EX_akg_e;b3738;;akg_e --> ;0.0;0.0 +EX_co2_e;b3738;;co2_e <=> ;22.809833310205086;0.0 +EX_etoh_e;b3738;;etoh_e --> ;0.0;0.0 +EX_for_e;b3738;;for_e --> ;0.0;15.44992606562578 +EX_fru_e;b3738;;fru_e --> ;0.0;0.0 +EX_fum_e;b3738;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3738;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3738;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3738;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3738;;h_e <=> ;17.530865429786523;37.26924460261309 +EX_h2o_e;b3738;;h2o_e <=> ;29.175827135565836;2.726040100962767 +EX_lac__D_e;b3738;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3738;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3738;;nh4_e <=> ;-4.765319193197444;-2.04060066203526 +EX_o2_e;b3738;;o2_e <=> ;-21.799492655998886;-7.292315874402727 +EX_pi_e;b3738;;pi_e <=> ;-3.214895047684769;-1.3766794409164365 +EX_pyr_e;b3738;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3738;;succ_e --> ;0.0;0.0 +FBA;b3738;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037 +FBP;b3738;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3738;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3738;;for_c --> for_e;0.0;15.44992606562578 +FRD7;b3738;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3738;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3738;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b3738;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3738;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b3738;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316 +GLCpts;b3738;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3738;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614 +GLNabc;b3738;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3738;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864 +GLUN;b3738;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3738;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3738;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3738;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b3738;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767 +ICDHyr;b3738;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315 +ICL;b3738;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3738;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3738;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3738;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3738;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b3738;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3738;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3738;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455 +NADTRHD;b3738;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3738;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526 +O2t;b3738;;o2_e <=> o2_c;21.799492655998886;7.292315874402727 +PDH;b3738;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876 +PFK;b3738;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037 +PFL;b3738;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578 +PGI;b3738;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714 +PGK;b3738;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532 +PGL;b3738;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b3738;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385 +PIt2r;b3738;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365 +PPC;b3738;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319 +PPCK;b3738;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3738;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3738;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123 +PYK;b3738;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855 +PYRt2;b3738;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3738;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193 +RPI;b3738;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926 +SUCCt2_2;b3738;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856 +SUCCt3;b3738;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856 +SUCDi;b3738;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b3738;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b3738;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335 +THD2;b3738;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592 +TKT1;b3738;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334 +TKT2;b3738;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592 +TPI;b3738;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037 +ACALD;b3731;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3731;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3731;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123 +ACONTa;b3731;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314 +ACONTb;b3731;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315 +ACt2r;b3731;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124 +ADK1;b3731;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3731;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b3731;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3731;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3731;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3731;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0 +Biomass_Ecoli_core;b3731;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097 +CO2t;b3731;;co2_e <=> co2_c;-22.809833310205086;0.0 +CS;b3731;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314 +CYTBD;b3731;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457 +D_LACt2;b3731;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3731;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385 +ETOHt2r;b3731;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3731;;ac_e --> ;0.0;14.312267245829124 +EX_acald_e;b3731;;acald_e --> ;0.0;0.0 +EX_akg_e;b3731;;akg_e --> ;0.0;0.0 +EX_co2_e;b3731;;co2_e <=> ;22.809833310205086;0.0 +EX_etoh_e;b3731;;etoh_e --> ;0.0;0.0 +EX_for_e;b3731;;for_e --> ;0.0;15.44992606562578 +EX_fru_e;b3731;;fru_e --> ;0.0;0.0 +EX_fum_e;b3731;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3731;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3731;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3731;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3731;;h_e <=> ;17.530865429786523;37.26924460261309 +EX_h2o_e;b3731;;h2o_e <=> ;29.175827135565836;2.726040100962767 +EX_lac__D_e;b3731;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3731;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3731;;nh4_e <=> ;-4.765319193197444;-2.04060066203526 +EX_o2_e;b3731;;o2_e <=> ;-21.799492655998886;-7.292315874402727 +EX_pi_e;b3731;;pi_e <=> ;-3.214895047684769;-1.3766794409164365 +EX_pyr_e;b3731;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3731;;succ_e --> ;0.0;0.0 +FBA;b3731;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037 +FBP;b3731;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3731;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3731;;for_c --> for_e;0.0;15.44992606562578 +FRD7;b3731;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3731;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3731;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b3731;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3731;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b3731;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316 +GLCpts;b3731;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3731;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614 +GLNabc;b3731;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3731;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864 +GLUN;b3731;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3731;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3731;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3731;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b3731;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767 +ICDHyr;b3731;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315 +ICL;b3731;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3731;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3731;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3731;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3731;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b3731;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3731;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3731;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455 +NADTRHD;b3731;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3731;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526 +O2t;b3731;;o2_e <=> o2_c;21.799492655998886;7.292315874402727 +PDH;b3731;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876 +PFK;b3731;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037 +PFL;b3731;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578 +PGI;b3731;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714 +PGK;b3731;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532 +PGL;b3731;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b3731;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385 +PIt2r;b3731;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365 +PPC;b3731;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319 +PPCK;b3731;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3731;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3731;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123 +PYK;b3731;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855 +PYRt2;b3731;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3731;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193 +RPI;b3731;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926 +SUCCt2_2;b3731;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856 +SUCCt3;b3731;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856 +SUCDi;b3731;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b3731;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b3731;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335 +THD2;b3731;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592 +TKT1;b3731;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334 +TKT2;b3731;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592 +TPI;b3731;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037 +ACALD;b3737;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3737;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3737;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123 +ACONTa;b3737;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314 +ACONTb;b3737;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315 +ACt2r;b3737;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124 +ADK1;b3737;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3737;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b3737;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3737;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3737;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3737;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0 +Biomass_Ecoli_core;b3737;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097 +CO2t;b3737;;co2_e <=> co2_c;-22.809833310205086;0.0 +CS;b3737;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314 +CYTBD;b3737;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457 +D_LACt2;b3737;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3737;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385 +ETOHt2r;b3737;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3737;;ac_e --> ;0.0;14.312267245829124 +EX_acald_e;b3737;;acald_e --> ;0.0;0.0 +EX_akg_e;b3737;;akg_e --> ;0.0;0.0 +EX_co2_e;b3737;;co2_e <=> ;22.809833310205086;0.0 +EX_etoh_e;b3737;;etoh_e --> ;0.0;0.0 +EX_for_e;b3737;;for_e --> ;0.0;15.44992606562578 +EX_fru_e;b3737;;fru_e --> ;0.0;0.0 +EX_fum_e;b3737;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3737;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3737;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3737;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3737;;h_e <=> ;17.530865429786523;37.26924460261309 +EX_h2o_e;b3737;;h2o_e <=> ;29.175827135565836;2.726040100962767 +EX_lac__D_e;b3737;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3737;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3737;;nh4_e <=> ;-4.765319193197444;-2.04060066203526 +EX_o2_e;b3737;;o2_e <=> ;-21.799492655998886;-7.292315874402727 +EX_pi_e;b3737;;pi_e <=> ;-3.214895047684769;-1.3766794409164365 +EX_pyr_e;b3737;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3737;;succ_e --> ;0.0;0.0 +FBA;b3737;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037 +FBP;b3737;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3737;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3737;;for_c --> for_e;0.0;15.44992606562578 +FRD7;b3737;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3737;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3737;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b3737;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3737;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b3737;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316 +GLCpts;b3737;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3737;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614 +GLNabc;b3737;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3737;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864 +GLUN;b3737;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3737;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3737;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3737;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b3737;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767 +ICDHyr;b3737;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315 +ICL;b3737;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3737;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3737;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3737;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3737;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b3737;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3737;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3737;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455 +NADTRHD;b3737;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3737;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526 +O2t;b3737;;o2_e <=> o2_c;21.799492655998886;7.292315874402727 +PDH;b3737;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876 +PFK;b3737;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037 +PFL;b3737;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578 +PGI;b3737;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714 +PGK;b3737;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532 +PGL;b3737;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b3737;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385 +PIt2r;b3737;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365 +PPC;b3737;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319 +PPCK;b3737;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3737;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3737;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123 +PYK;b3737;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855 +PYRt2;b3737;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3737;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193 +RPI;b3737;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926 +SUCCt2_2;b3737;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856 +SUCCt3;b3737;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856 +SUCDi;b3737;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b3737;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b3737;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335 +THD2;b3737;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592 +TKT1;b3737;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334 +TKT2;b3737;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592 +TPI;b3737;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037 +ACALD;b3739;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3739;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3739;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;9.254629107952257e-15 +ACONTa;b3739;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.00724957535033 +ACONTb;b3739;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350331 +ACt2r;b3739;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3739;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3739;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3739;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3739;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3739;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3739;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454 +Biomass_Ecoli_core;b3739;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684303 +CO2t;b3739;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204958 +CS;b3739;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.00724957535033 +CYTBD;b3739;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199752 +D_LACt2;b3739;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3739;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283 +ETOHt2r;b3739;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3739;;ac_e --> ;0.0;0.0 +EX_acald_e;b3739;;acald_e --> ;0.0;0.0 +EX_akg_e;b3739;;akg_e --> ;0.0;0.0 +EX_co2_e;b3739;;co2_e <=> ;22.809833310205086;22.809833310204958 +EX_etoh_e;b3739;;etoh_e --> ;0.0;0.0 +EX_for_e;b3739;;for_e --> ;0.0;0.0 +EX_fru_e;b3739;;fru_e --> ;0.0;0.0 +EX_fum_e;b3739;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3739;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3739;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3739;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3739;;h_e <=> ;17.530865429786523;17.530865429786697 +EX_h2o_e;b3739;;h2o_e <=> ;29.175827135565836;29.175827135565818 +EX_lac__D_e;b3739;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3739;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3739;;nh4_e <=> ;-4.765319193197444;-4.765319193197454 +EX_o2_e;b3739;;o2_e <=> ;-21.799492655998886;-21.799492655998755 +EX_pi_e;b3739;;pi_e <=> ;-3.214895047684769;-3.214895047684765 +EX_pyr_e;b3739;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3739;;succ_e --> ;0.0;0.0 +FBA;b3739;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160285 +FBP;b3739;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3739;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3739;;for_c --> for_e;0.0;0.0 +FRD7;b3739;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3739;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3739;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482092 +FUMt2_2;b3739;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3739;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3739;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604 +GLCpts;b3739;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3739;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2234617293318274 +GLNabc;b3739;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3739;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865628 +GLUN;b3739;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3739;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3739;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3739;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3739;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565818 +ICDHyr;b3739;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350331 +ICL;b3739;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3739;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3739;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3739;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3739;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482092 +ME1;b3739;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3739;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3739;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051542 +NADTRHD;b3739;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3739;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197454 +O2t;b3739;;o2_e <=> o2_c;21.799492655998886;21.799492655998755 +PDH;b3739;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166615 +PFK;b3739;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160285 +PFL;b3739;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3739;;g6p_c <=> f6p_c;4.860861146496871;4.86086114649682 +PGK;b3739;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608 +PGL;b3739;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3739;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283 +PIt2r;b3739;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684765 +PPC;b3739;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368733 +PPCK;b3739;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3739;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3739;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;-9.254629107952257e-15 +PYK;b3739;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067854 +PYRt2;b3739;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3739;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507528 +RPI;b3739;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671255 +SUCCt2_2;b3739;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3739;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3739;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482093 +SUCOAS;b3739;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482093 +TALA;b3739;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3739;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3739;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3739;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459627 +TPI;b3739;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160285 +ACALD;b0720;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0720;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0720;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-20.00000000000002 +ACONTa;b0720;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.0 +ACONTb;b0720;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.0 +ACt2r;b0720;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-20.000000000000025 +ADK1;b0720;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0720;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0720;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0720;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0720;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;90.00000000000013 +ATPS4r;b0720;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;50.00000000000003 +Biomass_Ecoli_core;b0720;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;-5.395886756813222e-16 +CO2t;b0720;;co2_e <=> co2_c;-22.809833310205086;-20.00000000000002 +CS;b0720;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.0 +CYTBD;b0720;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;40.00000000000003 +D_LACt2;b0720;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0720;;2pg_c <=> h2o_c + pep_c;14.716139568742859;20.000000000000007 +ETOHt2r;b0720;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0720;;ac_e --> ;0.0;20.000000000000025 +EX_acald_e;b0720;;acald_e --> ;0.0;0.0 +EX_akg_e;b0720;;akg_e --> ;0.0;0.0 +EX_co2_e;b0720;;co2_e <=> ;22.809833310205086;20.00000000000002 +EX_etoh_e;b0720;;etoh_e --> ;0.0;0.0 +EX_for_e;b0720;;for_e --> ;0.0;0.0 +EX_fru_e;b0720;;fru_e --> ;0.0;0.0 +EX_fum_e;b0720;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0720;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0720;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0720;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0720;;h_e <=> ;17.530865429786523;20.00000000000002 +EX_h2o_e;b0720;;h2o_e <=> ;29.175827135565836;19.99999999999997 +EX_lac__D_e;b0720;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0720;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0720;;nh4_e <=> ;-4.765319193197444;2.942269130755113e-15 +EX_o2_e;b0720;;o2_e <=> ;-21.799492655998886;-20.00000000000001 +EX_pi_e;b0720;;pi_e <=> ;-3.214895047684769;-4.60564284101701e-15 +EX_pyr_e;b0720;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0720;;succ_e --> ;0.0;-7.63962187873116e-16 +FBA;b0720;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;10.000000000000004 +FBP;b0720;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0720;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0720;;for_c --> for_e;0.0;0.0 +FRD7;b0720;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0720;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0720;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;3.0389888080807195e-15 +FUMt2_2;b0720;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0720;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;-4.9170018071460485e-15 +GAPD;b0720;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;20.000000000000007 +GLCpts;b0720;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0720;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;-1.3797282437171408e-16 +GLNabc;b0720;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0720;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;2.804296306383399e-15 +GLUN;b0720;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0720;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0720;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0720;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;-4.917001807146048e-15 +H2Ot;b0720;;h2o_e <=> h2o_c;-29.175827135565836;-19.99999999999997 +ICDHyr;b0720;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.0 +ICL;b0720;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0720;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0720;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0720;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0720;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;3.03898880808072e-15 +ME1;b0720;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0720;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0720;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.00000000000002 +NADTRHD;b0720;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0720;;nh4_e <=> nh4_c;4.765319193197444;-2.942269130755113e-15 +O2t;b0720;;o2_e <=> o2_c;21.799492655998886;20.00000000000001 +PDH;b0720;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;20.000000000000018 +PFK;b0720;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;10.000000000000004 +PFL;b0720;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0720;;g6p_c <=> f6p_c;4.860861146496871;10.000000000000007 +PGK;b0720;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-20.00000000000001 +PGL;b0720;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;-4.9170018071460485e-15 +PGM;b0720;;2pg_c <=> 3pg_c;-14.716139568742859;-20.000000000000004 +PIt2r;b0720;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;4.60564284101701e-15 +PPC;b0720;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;-9.60794076238377e-15 +PPCK;b0720;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0720;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0720;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;20.000000000000025 +PYK;b0720;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;10.000000000000018 +PYRt2;b0720;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0720;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-5.659747629010557e-15 +RPI;b0720;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-7.427458218645089e-16 +SUCCt2_2;b0720;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0720;;h_e + succ_c --> h_c + succ_e;0.0;-7.63962187873116e-16 +SUCDi;b0720;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b0720;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-2.275026620207604e-15 +TALA;b0720;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-4.312070952628888e-15 +THD2;b0720;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0720;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-4.312070952628887e-15 +TKT2;b0720;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-1.34767667638167e-15 +TPI;b0720;;dhap_c <=> g3p_c;7.477381962160304;10.000000000000004 +ACALD;b0733;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0733;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0733;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;1.7321003913454993e-15 +ACONTa;b0733;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350328 +ACONTb;b0733;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350328 +ACt2r;b0733;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0733;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0733;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482086 +AKGt2r;b0733;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0733;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0733;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0733;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451739 +Biomass_Ecoli_core;b0733;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.873921506968431 +CO2t;b0733;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204947 +CS;b0733;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350327 +CYTBD;b0733;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.5989853119975 +D_LACt2;b0733;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0733;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742829 +ETOHt2r;b0733;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0733;;ac_e --> ;0.0;0.0 +EX_acald_e;b0733;;acald_e --> ;0.0;0.0 +EX_akg_e;b0733;;akg_e --> ;0.0;0.0 +EX_co2_e;b0733;;co2_e <=> ;22.809833310205086;22.809833310204947 +EX_etoh_e;b0733;;etoh_e --> ;0.0;0.0 +EX_for_e;b0733;;for_e --> ;0.0;0.0 +EX_fru_e;b0733;;fru_e --> ;0.0;0.0 +EX_fum_e;b0733;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0733;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0733;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0733;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0733;;h_e <=> ;17.530865429786523;17.530865429786836 +EX_h2o_e;b0733;;h2o_e <=> ;29.175827135565836;29.175827135565683 +EX_lac__D_e;b0733;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0733;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0733;;nh4_e <=> ;-4.765319193197444;-4.76531919319746 +EX_o2_e;b0733;;o2_e <=> ;-21.799492655998886;-21.799492655998748 +EX_pi_e;b0733;;pi_e <=> ;-3.214895047684769;-3.214895047684807 +EX_pyr_e;b0733;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0733;;succ_e --> ;0.0;0.0 +FBA;b0733;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160281 +FBP;b0733;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0733;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0733;;for_c --> for_e;0.0;0.0 +FRD7;b0733;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0733;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0733;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482088 +FUMt2_2;b0733;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0733;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574665 +GAPD;b0733;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.0235261431676 +GLCpts;b0733;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0733;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2234617293318277 +GLNabc;b0733;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0733;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632 +GLUN;b0733;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0733;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0733;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0733;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574664 +H2Ot;b0733;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565683 +ICDHyr;b0733;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350326 +ICL;b0733;;icit_c --> glx_c + succ_c;0.0;4.1211941306032897e-16 +LDH_D;b0733;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0733;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0733;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0733;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482089 +ME1;b0733;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0733;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0733;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051541 +NADTRHD;b0733;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0733;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197461 +O2t;b0733;;o2_e <=> o2_c;21.799492655998886;21.799492655998748 +PDH;b0733;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916661 +PFK;b0733;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.4773819621602815 +PFL;b0733;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0733;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496808 +PGK;b0733;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167604 +PGL;b0733;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574665 +PGM;b0733;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742829 +PIt2r;b0733;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684807 +PPC;b0733;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687365 +PPCK;b0733;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0733;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0733;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;-1.7321003913454993e-15 +PYK;b0733;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067786 +PYRt2;b0733;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0733;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075343 +RPI;b0733;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.28150309406713 +SUCCt2_2;b0733;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0733;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0733;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482088 +SUCOAS;b0733;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482087 +TALA;b0733;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615692 +THD2;b0733;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0733;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261569 +TKT2;b0733;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459656 +TPI;b0733;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160281 +ACALD;b0979;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0979;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0979;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0979;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0979;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0979;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0979;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0979;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0979;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0979;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0979;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0979;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0979;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0979;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0979;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0979;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0979;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0979;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0979;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0979;;ac_e --> ;0.0;0.0 +EX_acald_e;b0979;;acald_e --> ;0.0;0.0 +EX_akg_e;b0979;;akg_e --> ;0.0;0.0 +EX_co2_e;b0979;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0979;;etoh_e --> ;0.0;0.0 +EX_for_e;b0979;;for_e --> ;0.0;0.0 +EX_fru_e;b0979;;fru_e --> ;0.0;0.0 +EX_fum_e;b0979;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0979;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0979;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0979;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0979;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0979;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0979;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0979;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0979;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0979;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0979;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0979;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0979;;succ_e --> ;0.0;0.0 +FBA;b0979;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0979;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0979;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0979;;for_c --> for_e;0.0;0.0 +FRD7;b0979;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0979;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0979;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0979;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0979;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0979;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0979;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0979;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0979;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0979;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0979;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0979;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0979;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0979;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0979;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0979;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0979;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0979;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0979;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0979;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0979;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0979;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0979;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0979;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0979;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0979;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0979;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0979;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0979;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0979;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0979;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0979;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0979;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0979;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0979;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0979;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0979;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0979;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0979;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0979;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0979;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0979;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0979;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0979;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0979;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0979;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0979;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0979;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0979;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0979;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0979;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0979;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0978;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0978;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0978;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0978;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0978;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0978;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0978;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0978;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0978;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0978;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0978;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0978;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0978;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0978;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0978;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0978;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0978;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0978;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0978;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0978;;ac_e --> ;0.0;0.0 +EX_acald_e;b0978;;acald_e --> ;0.0;0.0 +EX_akg_e;b0978;;akg_e --> ;0.0;0.0 +EX_co2_e;b0978;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0978;;etoh_e --> ;0.0;0.0 +EX_for_e;b0978;;for_e --> ;0.0;0.0 +EX_fru_e;b0978;;fru_e --> ;0.0;0.0 +EX_fum_e;b0978;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0978;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0978;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0978;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0978;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0978;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0978;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0978;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0978;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0978;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0978;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0978;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0978;;succ_e --> ;0.0;0.0 +FBA;b0978;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0978;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0978;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0978;;for_c --> for_e;0.0;0.0 +FRD7;b0978;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0978;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0978;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0978;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0978;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0978;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0978;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0978;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0978;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0978;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0978;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0978;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0978;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0978;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0978;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0978;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0978;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0978;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0978;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0978;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0978;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0978;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0978;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0978;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0978;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0978;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0978;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0978;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0978;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0978;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0978;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0978;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0978;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0978;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0978;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0978;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0978;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0978;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0978;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0978;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0978;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0978;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0978;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0978;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0978;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0978;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0978;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0978;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0978;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0978;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0978;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0978;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0734;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0734;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0734;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0734;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0734;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0734;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0734;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0734;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0734;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0734;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0734;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0734;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0734;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0734;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0734;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0734;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0734;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0734;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0734;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0734;;ac_e --> ;0.0;0.0 +EX_acald_e;b0734;;acald_e --> ;0.0;0.0 +EX_akg_e;b0734;;akg_e --> ;0.0;0.0 +EX_co2_e;b0734;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0734;;etoh_e --> ;0.0;0.0 +EX_for_e;b0734;;for_e --> ;0.0;0.0 +EX_fru_e;b0734;;fru_e --> ;0.0;0.0 +EX_fum_e;b0734;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0734;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0734;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0734;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0734;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0734;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0734;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0734;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0734;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0734;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0734;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0734;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0734;;succ_e --> ;0.0;0.0 +FBA;b0734;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0734;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0734;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0734;;for_c --> for_e;0.0;0.0 +FRD7;b0734;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0734;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0734;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0734;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0734;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0734;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0734;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0734;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0734;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0734;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0734;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0734;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0734;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0734;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0734;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0734;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0734;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0734;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0734;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0734;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0734;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0734;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0734;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0734;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0734;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0734;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0734;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0734;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0734;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0734;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0734;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0734;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0734;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0734;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0734;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0734;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0734;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0734;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0734;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0734;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0734;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0734;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0734;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0734;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0734;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0734;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0734;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0734;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0734;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0734;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0734;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0734;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2975;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2975;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2975;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2975;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2975;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2975;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2975;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2975;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2975;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2975;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2975;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2975;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2975;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2975;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2975;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2975;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2975;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2975;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2975;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2975;;ac_e --> ;0.0;0.0 +EX_acald_e;b2975;;acald_e --> ;0.0;0.0 +EX_akg_e;b2975;;akg_e --> ;0.0;0.0 +EX_co2_e;b2975;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2975;;etoh_e --> ;0.0;0.0 +EX_for_e;b2975;;for_e --> ;0.0;0.0 +EX_fru_e;b2975;;fru_e --> ;0.0;0.0 +EX_fum_e;b2975;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2975;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2975;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2975;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2975;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2975;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2975;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2975;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2975;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2975;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2975;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2975;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2975;;succ_e --> ;0.0;0.0 +FBA;b2975;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2975;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2975;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2975;;for_c --> for_e;0.0;0.0 +FRD7;b2975;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2975;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2975;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2975;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2975;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2975;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2975;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2975;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2975;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2975;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2975;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2975;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2975;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2975;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2975;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2975;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2975;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2975;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2975;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2975;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2975;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2975;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2975;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2975;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2975;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2975;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2975;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2975;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2975;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2975;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2975;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2975;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2975;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2975;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2975;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2975;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2975;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2975;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2975;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2975;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2975;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2975;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2975;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2975;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2975;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2975;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2975;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2975;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2975;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2975;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2975;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2975;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3603;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3603;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3603;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3603;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3603;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3603;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3603;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3603;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3603;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3603;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3603;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3603;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3603;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3603;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3603;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3603;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3603;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3603;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3603;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3603;;ac_e --> ;0.0;0.0 +EX_acald_e;b3603;;acald_e --> ;0.0;0.0 +EX_akg_e;b3603;;akg_e --> ;0.0;0.0 +EX_co2_e;b3603;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3603;;etoh_e --> ;0.0;0.0 +EX_for_e;b3603;;for_e --> ;0.0;0.0 +EX_fru_e;b3603;;fru_e --> ;0.0;0.0 +EX_fum_e;b3603;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3603;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3603;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3603;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3603;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3603;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3603;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3603;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3603;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3603;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3603;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3603;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3603;;succ_e --> ;0.0;0.0 +FBA;b3603;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3603;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3603;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3603;;for_c --> for_e;0.0;0.0 +FRD7;b3603;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3603;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3603;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3603;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3603;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3603;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3603;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3603;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3603;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3603;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3603;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3603;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3603;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3603;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3603;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3603;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3603;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3603;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3603;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3603;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3603;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3603;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3603;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3603;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3603;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3603;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3603;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3603;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3603;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3603;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3603;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3603;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3603;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3603;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3603;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3603;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3603;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3603;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3603;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3603;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3603;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3603;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3603;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3603;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3603;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3603;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3603;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3603;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3603;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3603;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3603;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3603;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2779;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2779;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2779;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2779;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;-3.791374141075912e-15 +ACONTb;b2779;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;-3.791374141075912e-15 +ACt2r;b2779;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2779;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.6453846153846249 +AKGDH;b2779;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2779;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2779;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2779;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2779;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;9.680769230769343 +Biomass_Ecoli_core;b2779;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;1.5208622319983277e-15 +CO2t;b2779;;co2_e <=> co2_c;-22.809833310205086;-3.8723076923077517 +CS;b2779;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;-3.791374141075912e-15 +CYTBD;b2779;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;7.744615384615493 +D_LACt2;b2779;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2779;;2pg_c --> h2o_c + pep_c;14.716139568742859;0.0 +ETOHt2r;b2779;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2779;;ac_e --> ;0.0;0.0 +EX_acald_e;b2779;;acald_e --> ;0.0;0.0 +EX_akg_e;b2779;;akg_e --> ;0.0;0.0 +EX_co2_e;b2779;;co2_e <=> ;22.809833310205086;3.8723076923077517 +EX_etoh_e;b2779;;etoh_e --> ;0.0;0.0 +EX_for_e;b2779;;for_e --> ;0.0;0.0 +EX_fru_e;b2779;;fru_e --> ;0.0;0.0 +EX_fum_e;b2779;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2779;;glc__D_e <=> ;-10.0;-0.6453846153846285 +EX_gln__L_e;b2779;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2779;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2779;;h_e <=> ;17.530865429786523;1.2297753566676806e-14 +EX_h2o_e;b2779;;h2o_e <=> ;29.175827135565836;3.872307692307758 +EX_lac__D_e;b2779;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2779;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2779;;nh4_e <=> ;-4.765319193197444;-1.0039929875026324e-14 +EX_o2_e;b2779;;o2_e <=> ;-21.799492655998886;-3.872307692307746 +EX_pi_e;b2779;;pi_e <=> ;-3.214895047684769;-6.966034797038227e-14 +EX_pyr_e;b2779;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2779;;succ_e --> ;0.0;0.0 +FBA;b2779;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;-0.6453846153846229 +FBP;b2779;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.6453846153846228 +FORt2;b2779;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2779;;for_c --> for_e;0.0;0.0 +FRD7;b2779;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2779;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2779;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;1.0811527192255712e-15 +FUMt2_2;b2779;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2779;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;3.8723076923077535 +GAPD;b2779;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;4.7992287954955166e-15 +GLCpts;b2779;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.6453846153846289 +GLNS;b2779;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;3.8888447272197235e-16 +GLNabc;b2779;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2779;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-7.904073105918508e-15 +GLUN;b2779;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2779;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2779;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2779;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;3.872307692307753 +H2Ot;b2779;;h2o_e <=> h2o_c;-29.175827135565836;-3.872307692307758 +ICDHyr;b2779;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;-1.9995554722307993e-16 +ICL;b2779;;icit_c --> glx_c + succ_c;0.0;-3.591418593852833e-15 +LDH_D;b2779;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2779;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-3.591418593852833e-15 +MALt2_2;b2779;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2779;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-2.5102658746272617e-15 +ME1;b2779;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2779;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2779;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;7.744615384615491 +NADTRHD;b2779;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;7.744615384615479 +NH4t;b2779;;nh4_e <=> nh4_c;4.765319193197444;7.149316221901999e-15 +O2t;b2779;;o2_e <=> o2_c;21.799492655998886;3.872307692307746 +PDH;b2779;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2779;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.0 +PFL;b2779;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2779;;g6p_c <=> f6p_c;4.860861146496871;-3.2269230769231245 +PGK;b2779;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-4.799228795495517e-15 +PGL;b2779;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;3.872307692307754 +PGM;b2779;;2pg_c <=> 3pg_c;-14.716139568742859;0.0 +PIt2r;b2779;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;6.966034797038227e-14 +PPC;b2779;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0 +PPCK;b2779;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;-1.8273994358831978e-15 +PPS;b2779;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.6453846153846249 +PTAr;b2779;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2779;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b2779;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2779;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.5815384615385004 +RPI;b2779;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-1.2907692307692535 +SUCCt2_2;b2779;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2779;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2779;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;1.081152719225571e-15 +SUCOAS;b2779;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-4.672571313078404e-15 +TALA;b2779;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.2907692307692507 +THD2;b2779;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2779;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.2907692307692504 +TKT2;b2779;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.2907692307692502 +TPI;b2779;;dhap_c <=> g3p_c;7.477381962160304;-0.6453846153846229 +ACALD;b1773;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1773;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1773;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1773;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350336 +ACONTb;b1773;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350336 +ACt2r;b1773;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1773;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1773;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482088 +AKGt2r;b1773;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1773;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1773;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1773;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451744 +Biomass_Ecoli_core;b1773;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684303 +CO2t;b1773;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020496 +CS;b1773;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350335 +CYTBD;b1773;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1773;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1773;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742843 +ETOHt2r;b1773;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1773;;ac_e --> ;0.0;0.0 +EX_acald_e;b1773;;acald_e --> ;0.0;0.0 +EX_akg_e;b1773;;akg_e --> ;0.0;0.0 +EX_co2_e;b1773;;co2_e <=> ;22.809833310205086;22.80983331020496 +EX_etoh_e;b1773;;etoh_e --> ;0.0;0.0 +EX_for_e;b1773;;for_e --> ;0.0;0.0 +EX_fru_e;b1773;;fru_e --> ;0.0;0.0 +EX_fum_e;b1773;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1773;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1773;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1773;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1773;;h_e <=> ;17.530865429786523;17.530865429786765 +EX_h2o_e;b1773;;h2o_e <=> ;29.175827135565836;29.175827135565793 +EX_lac__D_e;b1773;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1773;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1773;;nh4_e <=> ;-4.765319193197444;-4.765319193197456 +EX_o2_e;b1773;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1773;;pi_e <=> ;-3.214895047684769;-3.2148950476848017 +EX_pyr_e;b1773;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1773;;succ_e --> ;0.0;0.0 +FBA;b1773;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160275 +FBP;b1773;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1773;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1773;;for_c --> for_e;0.0;0.0 +FRD7;b1773;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1773;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1773;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482089 +FUMt2_2;b1773;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1773;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574667 +GAPD;b1773;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.02352614316762 +GLCpts;b1773;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000009 +GLNS;b1773;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2234617293318276 +GLNabc;b1773;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1773;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865629 +GLUN;b1773;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1773;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1773;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1773;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574666 +H2Ot;b1773;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565793 +ICDHyr;b1773;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350326 +ICL;b1773;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1773;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1773;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1773;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1773;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482089 +ME1;b1773;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1773;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1773;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1773;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1773;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197456 +O2t;b1773;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1773;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166618 +PFK;b1773;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160288 +PFL;b1773;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1773;;g6p_c <=> f6p_c;4.860861146496871;4.8608611464968225 +PGK;b1773;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167615 +PGL;b1773;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574667 +PGM;b1773;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742843 +PIt2r;b1773;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476848017 +PPC;b1773;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368739 +PPCK;b1773;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1773;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1773;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1773;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067786 +PYRt2;b1773;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1773;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507536 +RPI;b1773;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671304 +SUCCt2_2;b1773;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1773;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1773;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482089 +SUCOAS;b1773;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482089 +TALA;b1773;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615698 +THD2;b1773;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1773;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615696 +TKT2;b1773;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459664 +TPI;b1773;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160275 +ACALD;b2925;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2925;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2925;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2925;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2925;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2925;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2925;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2925;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2925;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2925;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2925;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2925;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2925;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2925;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2925;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2925;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2925;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2925;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2925;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2925;;ac_e --> ;0.0;0.0 +EX_acald_e;b2925;;acald_e --> ;0.0;0.0 +EX_akg_e;b2925;;akg_e --> ;0.0;0.0 +EX_co2_e;b2925;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2925;;etoh_e --> ;0.0;0.0 +EX_for_e;b2925;;for_e --> ;0.0;0.0 +EX_fru_e;b2925;;fru_e --> ;0.0;0.0 +EX_fum_e;b2925;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2925;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2925;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2925;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2925;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2925;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2925;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2925;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2925;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2925;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2925;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2925;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2925;;succ_e --> ;0.0;0.0 +FBA;b2925;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2925;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2925;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2925;;for_c --> for_e;0.0;0.0 +FRD7;b2925;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2925;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2925;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2925;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2925;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2925;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2925;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2925;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2925;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2925;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2925;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2925;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2925;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2925;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2925;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2925;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2925;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2925;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2925;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2925;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2925;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2925;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2925;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2925;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2925;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2925;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2925;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2925;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2925;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2925;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2925;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2925;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2925;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2925;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2925;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2925;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2925;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2925;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2925;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2925;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2925;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2925;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2925;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2925;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2925;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2925;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2925;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2925;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2925;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2925;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2925;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2925;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2097;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2097;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2097;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2097;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2097;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2097;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2097;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2097;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2097;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2097;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2097;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2097;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2097;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2097;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2097;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2097;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2097;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2097;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2097;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2097;;ac_e --> ;0.0;0.0 +EX_acald_e;b2097;;acald_e --> ;0.0;0.0 +EX_akg_e;b2097;;akg_e --> ;0.0;0.0 +EX_co2_e;b2097;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2097;;etoh_e --> ;0.0;0.0 +EX_for_e;b2097;;for_e --> ;0.0;0.0 +EX_fru_e;b2097;;fru_e --> ;0.0;0.0 +EX_fum_e;b2097;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2097;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2097;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2097;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2097;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2097;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2097;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2097;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2097;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2097;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2097;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2097;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2097;;succ_e --> ;0.0;0.0 +FBA;b2097;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2097;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2097;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2097;;for_c --> for_e;0.0;0.0 +FRD7;b2097;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2097;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2097;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2097;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2097;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2097;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2097;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2097;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2097;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2097;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2097;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2097;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2097;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2097;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2097;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2097;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2097;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2097;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2097;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2097;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2097;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2097;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2097;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2097;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2097;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2097;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2097;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2097;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2097;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2097;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2097;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2097;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2097;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2097;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2097;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2097;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2097;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2097;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2097;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2097;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2097;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2097;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2097;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2097;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2097;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2097;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2097;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2097;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2097;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2097;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2097;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2097;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4232;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4232;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4232;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4232;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4232;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4232;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4232;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4232;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4232;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4232;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4232;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4232;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4232;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4232;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4232;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4232;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4232;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4232;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4232;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4232;;ac_e --> ;0.0;0.0 +EX_acald_e;b4232;;acald_e --> ;0.0;0.0 +EX_akg_e;b4232;;akg_e --> ;0.0;0.0 +EX_co2_e;b4232;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4232;;etoh_e --> ;0.0;0.0 +EX_for_e;b4232;;for_e --> ;0.0;0.0 +EX_fru_e;b4232;;fru_e --> ;0.0;0.0 +EX_fum_e;b4232;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4232;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4232;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4232;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4232;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4232;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4232;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4232;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4232;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4232;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4232;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4232;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4232;;succ_e --> ;0.0;0.0 +FBA;b4232;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4232;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4232;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4232;;for_c --> for_e;0.0;0.0 +FRD7;b4232;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4232;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4232;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4232;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4232;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4232;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4232;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4232;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4232;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4232;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4232;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4232;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4232;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4232;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4232;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4232;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4232;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4232;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4232;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4232;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4232;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4232;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4232;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4232;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4232;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4232;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4232;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4232;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4232;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4232;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4232;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4232;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4232;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4232;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4232;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4232;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4232;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4232;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4232;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4232;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4232;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4232;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4232;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4232;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4232;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4232;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4232;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4232;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4232;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4232;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4232;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4232;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3925;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3925;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3925;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3925;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3925;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3925;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3925;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3925;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3925;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3925;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3925;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3925;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3925;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3925;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3925;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3925;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3925;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3925;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3925;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3925;;ac_e --> ;0.0;0.0 +EX_acald_e;b3925;;acald_e --> ;0.0;0.0 +EX_akg_e;b3925;;akg_e --> ;0.0;0.0 +EX_co2_e;b3925;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3925;;etoh_e --> ;0.0;0.0 +EX_for_e;b3925;;for_e --> ;0.0;0.0 +EX_fru_e;b3925;;fru_e --> ;0.0;0.0 +EX_fum_e;b3925;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3925;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3925;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3925;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3925;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3925;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3925;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3925;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3925;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3925;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3925;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3925;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3925;;succ_e --> ;0.0;0.0 +FBA;b3925;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3925;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3925;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3925;;for_c --> for_e;0.0;0.0 +FRD7;b3925;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3925;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3925;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3925;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3925;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3925;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3925;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3925;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3925;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3925;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3925;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3925;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3925;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3925;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3925;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3925;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3925;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3925;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3925;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3925;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3925;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3925;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3925;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3925;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3925;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3925;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3925;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3925;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3925;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3925;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3925;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3925;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3925;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3925;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3925;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3925;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3925;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3925;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3925;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3925;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3925;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3925;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3925;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3925;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3925;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3925;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3925;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3925;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3925;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3925;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3925;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3925;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0904;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0904;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0904;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0904;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0904;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0904;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0904;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0904;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0904;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0904;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0904;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0904;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0904;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0904;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0904;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0904;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0904;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0904;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0904;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0904;;ac_e --> ;0.0;0.0 +EX_acald_e;b0904;;acald_e --> ;0.0;0.0 +EX_akg_e;b0904;;akg_e --> ;0.0;0.0 +EX_co2_e;b0904;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0904;;etoh_e --> ;0.0;0.0 +EX_for_e;b0904;;for_e --> ;0.0;0.0 +EX_fru_e;b0904;;fru_e --> ;0.0;0.0 +EX_fum_e;b0904;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0904;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0904;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0904;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0904;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0904;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0904;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0904;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0904;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0904;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0904;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0904;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0904;;succ_e --> ;0.0;0.0 +FBA;b0904;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0904;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0904;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0904;;for_c --> for_e;0.0;0.0 +FRD7;b0904;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0904;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0904;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0904;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0904;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0904;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0904;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0904;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0904;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0904;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0904;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0904;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0904;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0904;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0904;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0904;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0904;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0904;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0904;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0904;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0904;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0904;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0904;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0904;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0904;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0904;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0904;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0904;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0904;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0904;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0904;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0904;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0904;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0904;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0904;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0904;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0904;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0904;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0904;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0904;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0904;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0904;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0904;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0904;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0904;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0904;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0904;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0904;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0904;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0904;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0904;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0904;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2492;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2492;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2492;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2492;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2492;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2492;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2492;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2492;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2492;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2492;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2492;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2492;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2492;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2492;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2492;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2492;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2492;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2492;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2492;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2492;;ac_e --> ;0.0;0.0 +EX_acald_e;b2492;;acald_e --> ;0.0;0.0 +EX_akg_e;b2492;;akg_e --> ;0.0;0.0 +EX_co2_e;b2492;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2492;;etoh_e --> ;0.0;0.0 +EX_for_e;b2492;;for_e --> ;0.0;0.0 +EX_fru_e;b2492;;fru_e --> ;0.0;0.0 +EX_fum_e;b2492;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2492;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2492;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2492;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2492;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2492;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2492;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2492;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2492;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2492;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2492;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2492;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2492;;succ_e --> ;0.0;0.0 +FBA;b2492;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2492;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2492;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2492;;for_c --> for_e;0.0;0.0 +FRD7;b2492;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2492;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2492;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2492;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2492;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2492;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2492;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2492;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2492;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2492;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2492;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2492;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2492;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2492;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2492;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2492;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2492;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2492;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2492;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2492;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2492;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2492;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2492;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2492;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2492;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2492;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2492;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2492;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2492;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2492;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2492;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2492;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2492;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2492;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2492;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2492;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2492;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2492;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2492;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2492;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2492;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2492;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2492;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2492;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2492;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2492;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2492;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2492;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2492;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2492;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2492;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2492;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4154;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4154;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4154;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4154;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4154;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4154;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4154;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4154;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4154;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4154;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4154;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4154;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4154;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4154;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4154;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4154;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4154;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4154;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4154;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4154;;ac_e --> ;0.0;0.0 +EX_acald_e;b4154;;acald_e --> ;0.0;0.0 +EX_akg_e;b4154;;akg_e --> ;0.0;0.0 +EX_co2_e;b4154;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4154;;etoh_e --> ;0.0;0.0 +EX_for_e;b4154;;for_e --> ;0.0;0.0 +EX_fru_e;b4154;;fru_e --> ;0.0;0.0 +EX_fum_e;b4154;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4154;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4154;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4154;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4154;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4154;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4154;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4154;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4154;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4154;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4154;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4154;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4154;;succ_e --> ;0.0;0.0 +FBA;b4154;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4154;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4154;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4154;;for_c --> for_e;0.0;0.0 +FRD7;b4154;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4154;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4154;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4154;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4154;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4154;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4154;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4154;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4154;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4154;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4154;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4154;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4154;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4154;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4154;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4154;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4154;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4154;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4154;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4154;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4154;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4154;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4154;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4154;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4154;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4154;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4154;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4154;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4154;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4154;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4154;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4154;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4154;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4154;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4154;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4154;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4154;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4154;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4154;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4154;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4154;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4154;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4154;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4154;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4154;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4154;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4154;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4154;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4154;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4154;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4154;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4154;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4152;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4152;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4152;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4152;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4152;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4152;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4152;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4152;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4152;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4152;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4152;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4152;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4152;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4152;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4152;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4152;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4152;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4152;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4152;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4152;;ac_e --> ;0.0;0.0 +EX_acald_e;b4152;;acald_e --> ;0.0;0.0 +EX_akg_e;b4152;;akg_e --> ;0.0;0.0 +EX_co2_e;b4152;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4152;;etoh_e --> ;0.0;0.0 +EX_for_e;b4152;;for_e --> ;0.0;0.0 +EX_fru_e;b4152;;fru_e --> ;0.0;0.0 +EX_fum_e;b4152;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4152;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4152;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4152;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4152;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4152;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4152;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4152;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4152;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4152;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4152;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4152;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4152;;succ_e --> ;0.0;0.0 +FBA;b4152;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4152;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4152;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4152;;for_c --> for_e;0.0;0.0 +FRD7;b4152;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4152;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4152;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4152;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4152;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4152;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4152;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4152;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4152;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4152;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4152;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4152;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4152;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4152;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4152;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4152;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4152;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4152;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4152;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4152;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4152;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4152;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4152;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4152;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4152;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4152;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4152;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4152;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4152;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4152;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4152;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4152;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4152;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4152;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4152;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4152;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4152;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4152;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4152;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4152;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4152;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4152;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4152;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4152;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4152;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4152;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4152;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4152;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4152;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4152;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4152;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4152;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4153;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4153;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4153;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4153;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4153;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4153;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4153;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4153;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4153;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4153;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4153;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4153;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4153;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4153;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4153;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4153;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4153;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4153;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4153;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4153;;ac_e --> ;0.0;0.0 +EX_acald_e;b4153;;acald_e --> ;0.0;0.0 +EX_akg_e;b4153;;akg_e --> ;0.0;0.0 +EX_co2_e;b4153;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4153;;etoh_e --> ;0.0;0.0 +EX_for_e;b4153;;for_e --> ;0.0;0.0 +EX_fru_e;b4153;;fru_e --> ;0.0;0.0 +EX_fum_e;b4153;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4153;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4153;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4153;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4153;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4153;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4153;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4153;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4153;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4153;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4153;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4153;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4153;;succ_e --> ;0.0;0.0 +FBA;b4153;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4153;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4153;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4153;;for_c --> for_e;0.0;0.0 +FRD7;b4153;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4153;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4153;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4153;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4153;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4153;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4153;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4153;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4153;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4153;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4153;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4153;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4153;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4153;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4153;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4153;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4153;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4153;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4153;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4153;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4153;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4153;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4153;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4153;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4153;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4153;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4153;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4153;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4153;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4153;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4153;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4153;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4153;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4153;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4153;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4153;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4153;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4153;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4153;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4153;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4153;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4153;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4153;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4153;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4153;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4153;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4153;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4153;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4153;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4153;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4153;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4153;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4151;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4151;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4151;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4151;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4151;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4151;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4151;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4151;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4151;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4151;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4151;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4151;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4151;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4151;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4151;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4151;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4151;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4151;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4151;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4151;;ac_e --> ;0.0;0.0 +EX_acald_e;b4151;;acald_e --> ;0.0;0.0 +EX_akg_e;b4151;;akg_e --> ;0.0;0.0 +EX_co2_e;b4151;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4151;;etoh_e --> ;0.0;0.0 +EX_for_e;b4151;;for_e --> ;0.0;0.0 +EX_fru_e;b4151;;fru_e --> ;0.0;0.0 +EX_fum_e;b4151;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4151;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4151;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4151;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4151;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4151;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4151;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4151;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4151;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4151;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4151;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4151;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4151;;succ_e --> ;0.0;0.0 +FBA;b4151;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4151;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4151;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4151;;for_c --> for_e;0.0;0.0 +FRD7;b4151;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4151;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4151;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4151;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4151;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4151;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4151;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4151;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4151;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4151;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4151;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4151;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4151;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4151;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4151;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4151;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4151;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4151;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4151;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4151;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4151;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4151;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4151;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4151;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4151;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4151;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4151;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4151;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4151;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4151;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4151;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4151;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4151;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4151;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4151;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4151;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4151;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4151;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4151;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4151;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4151;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4151;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4151;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4151;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4151;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4151;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4151;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4151;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4151;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4151;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4151;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4151;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1819;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1819;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1819;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1819;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1819;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1819;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1819;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1819;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1819;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1819;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1819;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1819;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1819;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1819;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1819;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1819;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1819;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1819;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1819;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1819;;ac_e --> ;0.0;0.0 +EX_acald_e;b1819;;acald_e --> ;0.0;0.0 +EX_akg_e;b1819;;akg_e --> ;0.0;0.0 +EX_co2_e;b1819;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1819;;etoh_e --> ;0.0;0.0 +EX_for_e;b1819;;for_e --> ;0.0;0.0 +EX_fru_e;b1819;;fru_e --> ;0.0;0.0 +EX_fum_e;b1819;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1819;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1819;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1819;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1819;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1819;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1819;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1819;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1819;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1819;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1819;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1819;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1819;;succ_e --> ;0.0;0.0 +FBA;b1819;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1819;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1819;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1819;;for_c --> for_e;0.0;0.0 +FRD7;b1819;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1819;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1819;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1819;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1819;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1819;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1819;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1819;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1819;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1819;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1819;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1819;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1819;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1819;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1819;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1819;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1819;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1819;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1819;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1819;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1819;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1819;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1819;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1819;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1819;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1819;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1819;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1819;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1819;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1819;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1819;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1819;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1819;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1819;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1819;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1819;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1819;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1819;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1819;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1819;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1819;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1819;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1819;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1819;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1819;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1819;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1819;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1819;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1819;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1819;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1819;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1819;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1817;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1817;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1817;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1817;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1817;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1817;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1817;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1817;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1817;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1817;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1817;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1817;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1817;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1817;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1817;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1817;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1817;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1817;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1817;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1817;;ac_e --> ;0.0;0.0 +EX_acald_e;b1817;;acald_e --> ;0.0;0.0 +EX_akg_e;b1817;;akg_e --> ;0.0;0.0 +EX_co2_e;b1817;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1817;;etoh_e --> ;0.0;0.0 +EX_for_e;b1817;;for_e --> ;0.0;0.0 +EX_fru_e;b1817;;fru_e --> ;0.0;0.0 +EX_fum_e;b1817;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1817;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1817;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1817;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1817;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1817;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1817;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1817;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1817;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1817;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1817;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1817;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1817;;succ_e --> ;0.0;0.0 +FBA;b1817;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1817;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1817;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1817;;for_c --> for_e;0.0;0.0 +FRD7;b1817;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1817;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1817;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1817;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1817;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1817;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1817;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1817;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1817;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1817;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1817;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1817;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1817;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1817;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1817;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1817;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1817;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1817;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1817;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1817;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1817;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1817;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1817;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1817;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1817;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1817;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1817;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1817;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1817;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1817;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1817;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1817;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1817;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1817;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1817;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1817;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1817;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1817;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1817;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1817;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1817;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1817;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1817;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1817;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1817;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1817;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1817;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1817;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1817;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1817;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1817;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1817;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2415;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2415;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2415;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2415;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.9588571428571432 +ACONTb;b2415;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.9588571428571433 +ACt2r;b2415;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2415;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2415;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.9588571428571432 +AKGt2r;b2415;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2415;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2415;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2415;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;6.4722857142857135 +Biomass_Ecoli_core;b2415;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.0 +CO2t;b2415;;co2_e <=> co2_c;-22.809833310205086;-2.8765714285714292 +CS;b2415;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.9588571428571431 +CYTBD;b2415;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;5.753142857142859 +D_LACt2;b2415;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2415;;2pg_c <=> h2o_c + pep_c;14.716139568742859;0.9588571428571427 +ETOHt2r;b2415;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2415;;ac_e --> ;0.0;0.0 +EX_acald_e;b2415;;acald_e --> ;0.0;0.0 +EX_akg_e;b2415;;akg_e --> ;0.0;0.0 +EX_co2_e;b2415;;co2_e <=> ;22.809833310205086;2.8765714285714292 +EX_etoh_e;b2415;;etoh_e --> ;0.0;0.0 +EX_for_e;b2415;;for_e --> ;0.0;0.0 +EX_fru_e;b2415;;fru_e --> ;0.0;0.0 +EX_fum_e;b2415;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2415;;glc__D_e <=> ;-10.0;-0.47942857142857065 +EX_gln__L_e;b2415;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2415;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2415;;h_e <=> ;17.530865429786523;4.9191014266707225e-15 +EX_h2o_e;b2415;;h2o_e <=> ;29.175827135565836;2.8765714285714297 +EX_lac__D_e;b2415;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2415;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2415;;nh4_e <=> ;-4.765319193197444;0.0 +EX_o2_e;b2415;;o2_e <=> ;-21.799492655998886;-2.876571428571429 +EX_pi_e;b2415;;pi_e <=> ;-3.214895047684769;-1.44603579811754e-16 +EX_pyr_e;b2415;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2415;;succ_e --> ;0.0;0.0 +FBA;b2415;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;0.47942857142857126 +FBP;b2415;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2415;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2415;;for_c --> for_e;0.0;0.0 +FRD7;b2415;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2415;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2415;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.9588571428571431 +FUMt2_2;b2415;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2415;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2415;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;0.9588571428571426 +GLCpts;b2415;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.4794285714285713 +GLNS;b2415;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.0 +GLNabc;b2415;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2415;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;0.0 +GLUN;b2415;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2415;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2415;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2415;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2415;;h2o_e <=> h2o_c;-29.175827135565836;-2.8765714285714297 +ICDHyr;b2415;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9588571428571432 +ICL;b2415;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2415;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2415;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2415;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2415;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.9588571428571432 +ME1;b2415;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2415;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2415;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;4.794285714285715 +NADTRHD;b2415;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.9588571428571433 +NH4t;b2415;;nh4_e <=> nh4_c;4.765319193197444;0.0 +O2t;b2415;;o2_e <=> o2_c;21.799492655998886;2.876571428571429 +PDH;b2415;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.9588571428571431 +PFK;b2415;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.4794285714285713 +PFL;b2415;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2415;;g6p_c <=> f6p_c;4.860861146496871;0.4794285714285713 +PGK;b2415;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-0.9588571428571429 +PGL;b2415;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2415;;2pg_c <=> 3pg_c;-14.716139568742859;-0.9588571428571427 +PIt2r;b2415;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.44603579811754e-16 +PPC;b2415;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;-2.1787822771044144e-16 +PPCK;b2415;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2415;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2415;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2415;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.4794285714285715 +PYRt2;b2415;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2415;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;0.0 +RPI;b2415;;r5p_c <=> ru5p__D_c;-2.2815030940671064;0.0 +SUCCt2_2;b2415;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2415;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2415;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.9588571428571433 +SUCOAS;b2415;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-0.9588571428571433 +TALA;b2415;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;0.0 +THD2;b2415;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2415;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;0.0 +TKT2;b2415;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;0.0 +TPI;b2415;;dhap_c <=> g3p_c;7.477381962160304;0.47942857142857126 +ACALD;b1818;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1818;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1818;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1818;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350335 +ACONTb;b1818;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350335 +ACt2r;b1818;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1818;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1818;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482098 +AKGt2r;b1818;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1818;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1818;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1818;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451748 +Biomass_Ecoli_core;b1818;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306 +CO2t;b1818;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1818;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350334 +CYTBD;b1818;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754 +D_LACt2;b1818;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1818;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283 +ETOHt2r;b1818;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1818;;ac_e --> ;0.0;0.0 +EX_acald_e;b1818;;acald_e --> ;0.0;0.0 +EX_akg_e;b1818;;akg_e --> ;0.0;0.0 +EX_co2_e;b1818;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1818;;etoh_e --> ;0.0;0.0 +EX_for_e;b1818;;for_e --> ;0.0;0.0 +EX_fru_e;b1818;;fru_e --> ;0.0;0.0 +EX_fum_e;b1818;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1818;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1818;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1818;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1818;;h_e <=> ;17.530865429786523;17.530865429786658 +EX_h2o_e;b1818;;h2o_e <=> ;29.175827135565836;29.175827135565825 +EX_lac__D_e;b1818;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1818;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1818;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1818;;o2_e <=> ;-21.799492655998886;-21.799492655998765 +EX_pi_e;b1818;;pi_e <=> ;-3.214895047684769;-3.2148950476847853 +EX_pyr_e;b1818;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1818;;succ_e --> ;0.0;0.0 +FBA;b1818;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160285 +FBP;b1818;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1818;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1818;;for_c --> for_e;0.0;0.0 +FRD7;b1818;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1818;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1818;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097 +FUMt2_2;b1818;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1818;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574658 +GAPD;b1818;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604 +GLCpts;b1818;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1818;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182767 +GLNabc;b1818;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1818;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1818;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1818;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1818;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1818;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574656 +H2Ot;b1818;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825 +ICDHyr;b1818;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350335 +ICL;b1818;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1818;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1818;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1818;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1818;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482098 +ME1;b1818;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1818;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1818;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1818;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1818;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197457 +O2t;b1818;;o2_e <=> o2_c;21.799492655998886;21.799492655998765 +PDH;b1818;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166618 +PFK;b1818;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160285 +PFL;b1818;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1818;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496815 +PGK;b1818;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608 +PGL;b1818;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574657 +PGM;b1818;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283 +PIt2r;b1818;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847853 +PPC;b1818;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368731 +PPCK;b1818;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1818;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1818;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1818;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.758177444106787 +PYRt2;b1818;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1818;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075307 +RPI;b1818;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067126 +SUCCt2_2;b1818;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1818;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1818;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482098 +SUCOAS;b1818;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482098 +TALA;b1818;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615665 +THD2;b1818;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1818;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261566 +TKT2;b1818;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245963 +TPI;b1818;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160285 +ACALD;b2416;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2416;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2416;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2416;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.9588571428571432 +ACONTb;b2416;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.9588571428571433 +ACt2r;b2416;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2416;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2416;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.9588571428571432 +AKGt2r;b2416;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2416;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2416;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2416;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;6.4722857142857135 +Biomass_Ecoli_core;b2416;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.0 +CO2t;b2416;;co2_e <=> co2_c;-22.809833310205086;-2.8765714285714292 +CS;b2416;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.9588571428571431 +CYTBD;b2416;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;5.753142857142859 +D_LACt2;b2416;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2416;;2pg_c <=> h2o_c + pep_c;14.716139568742859;0.9588571428571427 +ETOHt2r;b2416;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2416;;ac_e --> ;0.0;0.0 +EX_acald_e;b2416;;acald_e --> ;0.0;0.0 +EX_akg_e;b2416;;akg_e --> ;0.0;0.0 +EX_co2_e;b2416;;co2_e <=> ;22.809833310205086;2.8765714285714292 +EX_etoh_e;b2416;;etoh_e --> ;0.0;0.0 +EX_for_e;b2416;;for_e --> ;0.0;0.0 +EX_fru_e;b2416;;fru_e --> ;0.0;0.0 +EX_fum_e;b2416;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2416;;glc__D_e <=> ;-10.0;-0.47942857142857065 +EX_gln__L_e;b2416;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2416;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2416;;h_e <=> ;17.530865429786523;4.9191014266707225e-15 +EX_h2o_e;b2416;;h2o_e <=> ;29.175827135565836;2.8765714285714297 +EX_lac__D_e;b2416;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2416;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2416;;nh4_e <=> ;-4.765319193197444;0.0 +EX_o2_e;b2416;;o2_e <=> ;-21.799492655998886;-2.876571428571429 +EX_pi_e;b2416;;pi_e <=> ;-3.214895047684769;-1.44603579811754e-16 +EX_pyr_e;b2416;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2416;;succ_e --> ;0.0;0.0 +FBA;b2416;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;0.47942857142857126 +FBP;b2416;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2416;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2416;;for_c --> for_e;0.0;0.0 +FRD7;b2416;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2416;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2416;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.9588571428571431 +FUMt2_2;b2416;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2416;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2416;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;0.9588571428571426 +GLCpts;b2416;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.4794285714285713 +GLNS;b2416;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.0 +GLNabc;b2416;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2416;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;0.0 +GLUN;b2416;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2416;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2416;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2416;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2416;;h2o_e <=> h2o_c;-29.175827135565836;-2.8765714285714297 +ICDHyr;b2416;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9588571428571432 +ICL;b2416;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2416;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2416;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2416;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2416;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.9588571428571432 +ME1;b2416;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2416;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2416;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;4.794285714285715 +NADTRHD;b2416;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.9588571428571433 +NH4t;b2416;;nh4_e <=> nh4_c;4.765319193197444;0.0 +O2t;b2416;;o2_e <=> o2_c;21.799492655998886;2.876571428571429 +PDH;b2416;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.9588571428571431 +PFK;b2416;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.4794285714285713 +PFL;b2416;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2416;;g6p_c <=> f6p_c;4.860861146496871;0.4794285714285713 +PGK;b2416;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-0.9588571428571429 +PGL;b2416;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2416;;2pg_c <=> 3pg_c;-14.716139568742859;-0.9588571428571427 +PIt2r;b2416;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.44603579811754e-16 +PPC;b2416;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;-2.1787822771044144e-16 +PPCK;b2416;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2416;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2416;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2416;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.4794285714285715 +PYRt2;b2416;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2416;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;0.0 +RPI;b2416;;r5p_c <=> ru5p__D_c;-2.2815030940671064;0.0 +SUCCt2_2;b2416;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2416;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2416;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.9588571428571433 +SUCOAS;b2416;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-0.9588571428571433 +TALA;b2416;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;0.0 +THD2;b2416;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2416;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;0.0 +TKT2;b2416;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;0.0 +TPI;b2416;;dhap_c <=> g3p_c;7.477381962160304;0.47942857142857126 +ACALD;b1611;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1611;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1611;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1611;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350335 +ACONTb;b1611;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350335 +ACt2r;b1611;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1611;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1611;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482098 +AKGt2r;b1611;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1611;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1611;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1611;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451748 +Biomass_Ecoli_core;b1611;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306 +CO2t;b1611;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1611;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350334 +CYTBD;b1611;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754 +D_LACt2;b1611;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1611;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283 +ETOHt2r;b1611;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1611;;ac_e --> ;0.0;0.0 +EX_acald_e;b1611;;acald_e --> ;0.0;0.0 +EX_akg_e;b1611;;akg_e --> ;0.0;0.0 +EX_co2_e;b1611;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1611;;etoh_e --> ;0.0;0.0 +EX_for_e;b1611;;for_e --> ;0.0;0.0 +EX_fru_e;b1611;;fru_e --> ;0.0;0.0 +EX_fum_e;b1611;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1611;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1611;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1611;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1611;;h_e <=> ;17.530865429786523;17.530865429786658 +EX_h2o_e;b1611;;h2o_e <=> ;29.175827135565836;29.175827135565825 +EX_lac__D_e;b1611;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1611;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1611;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1611;;o2_e <=> ;-21.799492655998886;-21.799492655998765 +EX_pi_e;b1611;;pi_e <=> ;-3.214895047684769;-3.2148950476847853 +EX_pyr_e;b1611;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1611;;succ_e --> ;0.0;0.0 +FBA;b1611;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160285 +FBP;b1611;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1611;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1611;;for_c --> for_e;0.0;0.0 +FRD7;b1611;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1611;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1611;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097 +FUMt2_2;b1611;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1611;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574658 +GAPD;b1611;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604 +GLCpts;b1611;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1611;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182767 +GLNabc;b1611;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1611;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1611;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1611;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1611;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1611;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574656 +H2Ot;b1611;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825 +ICDHyr;b1611;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350335 +ICL;b1611;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1611;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1611;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1611;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1611;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482098 +ME1;b1611;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1611;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1611;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1611;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1611;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197457 +O2t;b1611;;o2_e <=> o2_c;21.799492655998886;21.799492655998765 +PDH;b1611;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166618 +PFK;b1611;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160285 +PFL;b1611;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1611;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496815 +PGK;b1611;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608 +PGL;b1611;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574657 +PGM;b1611;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283 +PIt2r;b1611;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847853 +PPC;b1611;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368731 +PPCK;b1611;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1611;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1611;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1611;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.758177444106787 +PYRt2;b1611;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1611;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075307 +RPI;b1611;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067126 +SUCCt2_2;b1611;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1611;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1611;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482098 +SUCOAS;b1611;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482098 +TALA;b1611;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615665 +THD2;b1611;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1611;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261566 +TKT2;b1611;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245963 +TPI;b1611;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160285 +ACALD;b4122;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4122;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4122;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4122;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4122;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4122;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4122;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4122;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4122;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4122;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4122;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4122;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4122;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4122;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4122;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4122;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4122;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4122;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4122;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4122;;ac_e --> ;0.0;0.0 +EX_acald_e;b4122;;acald_e --> ;0.0;0.0 +EX_akg_e;b4122;;akg_e --> ;0.0;0.0 +EX_co2_e;b4122;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4122;;etoh_e --> ;0.0;0.0 +EX_for_e;b4122;;for_e --> ;0.0;0.0 +EX_fru_e;b4122;;fru_e --> ;0.0;0.0 +EX_fum_e;b4122;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4122;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4122;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4122;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4122;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4122;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4122;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4122;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4122;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4122;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4122;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4122;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4122;;succ_e --> ;0.0;0.0 +FBA;b4122;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4122;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4122;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4122;;for_c --> for_e;0.0;0.0 +FRD7;b4122;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4122;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4122;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4122;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4122;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4122;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4122;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4122;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4122;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4122;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4122;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4122;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4122;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4122;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4122;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4122;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4122;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4122;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4122;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4122;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4122;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4122;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4122;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4122;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4122;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4122;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4122;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4122;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4122;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4122;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4122;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4122;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4122;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4122;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4122;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4122;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4122;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4122;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4122;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4122;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4122;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4122;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4122;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4122;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4122;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4122;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4122;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4122;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4122;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4122;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4122;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4122;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1612;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1612;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1612;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1612;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1612;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1612;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1612;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1612;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1612;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1612;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1612;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1612;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1612;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1612;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1612;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1612;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1612;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1612;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1612;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1612;;ac_e --> ;0.0;0.0 +EX_acald_e;b1612;;acald_e --> ;0.0;0.0 +EX_akg_e;b1612;;akg_e --> ;0.0;0.0 +EX_co2_e;b1612;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1612;;etoh_e --> ;0.0;0.0 +EX_for_e;b1612;;for_e --> ;0.0;0.0 +EX_fru_e;b1612;;fru_e --> ;0.0;0.0 +EX_fum_e;b1612;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1612;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1612;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1612;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1612;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1612;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1612;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1612;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1612;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1612;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1612;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1612;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1612;;succ_e --> ;0.0;0.0 +FBA;b1612;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1612;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1612;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1612;;for_c --> for_e;0.0;0.0 +FRD7;b1612;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1612;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1612;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1612;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1612;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1612;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1612;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1612;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1612;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1612;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1612;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1612;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1612;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1612;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1612;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1612;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1612;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1612;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1612;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1612;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1612;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1612;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1612;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1612;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1612;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1612;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1612;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1612;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1612;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1612;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1612;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1612;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1612;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1612;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1612;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1612;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1612;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1612;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1612;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1612;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1612;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1612;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1612;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1612;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1612;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1612;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1612;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1612;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1612;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1612;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1612;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1612;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3528;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3528;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3528;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3528;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3528;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3528;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3528;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3528;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3528;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3528;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3528;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3528;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3528;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3528;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3528;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3528;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3528;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3528;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3528;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3528;;ac_e --> ;0.0;0.0 +EX_acald_e;b3528;;acald_e --> ;0.0;0.0 +EX_akg_e;b3528;;akg_e --> ;0.0;0.0 +EX_co2_e;b3528;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3528;;etoh_e --> ;0.0;0.0 +EX_for_e;b3528;;for_e --> ;0.0;0.0 +EX_fru_e;b3528;;fru_e --> ;0.0;0.0 +EX_fum_e;b3528;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3528;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3528;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3528;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3528;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3528;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3528;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3528;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3528;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3528;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3528;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3528;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3528;;succ_e --> ;0.0;0.0 +FBA;b3528;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3528;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3528;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3528;;for_c --> for_e;0.0;0.0 +FRD7;b3528;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3528;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3528;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3528;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3528;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3528;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3528;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3528;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3528;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3528;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3528;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3528;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3528;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3528;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3528;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3528;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3528;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3528;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3528;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3528;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3528;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3528;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3528;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3528;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3528;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3528;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3528;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3528;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3528;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3528;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3528;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3528;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3528;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3528;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3528;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3528;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3528;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3528;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3528;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3528;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3528;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3528;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3528;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3528;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3528;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3528;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3528;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3528;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3528;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3528;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3528;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3528;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1852;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1852;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1852;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1852;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;7.803301595127319 +ACONTb;b1852;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;7.80330159512732 +ACt2r;b1852;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1852;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1852;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;6.871333415503454 +AKGt2r;b1852;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1852;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1852;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1852;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;41.35354605121254 +Biomass_Ecoli_core;b1852;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.863813309504001 +CO2t;b1852;;co2_e <=> co2_c;-22.809833310205086;-23.239992707402525 +CS;b1852;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;7.803301595127319 +CYTBD;b1852;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.48267628056989 +D_LACt2;b1852;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1852;;2pg_c <=> h2o_c + pep_c;14.716139568742859;16.411460368327536 +ETOHt2r;b1852;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1852;;ac_e --> ;0.0;0.0 +EX_acald_e;b1852;;acald_e --> ;0.0;0.0 +EX_akg_e;b1852;;akg_e --> ;0.0;0.0 +EX_co2_e;b1852;;co2_e <=> ;22.809833310205086;23.239992707402525 +EX_etoh_e;b1852;;etoh_e --> ;0.0;0.0 +EX_for_e;b1852;;for_e --> ;0.0;0.0 +EX_fru_e;b1852;;fru_e --> ;0.0;0.0 +EX_fum_e;b1852;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1852;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1852;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1852;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1852;;h_e <=> ;17.530865429786523;17.328094988650292 +EX_h2o_e;b1852;;h2o_e <=> ;29.175827135565836;29.53235437915348 +EX_lac__D_e;b1852;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1852;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1852;;nh4_e <=> ;-4.765319193197444;-4.7102012140634155 +EX_o2_e;b1852;;o2_e <=> ;-21.799492655998886;-22.24133814028494 +EX_pi_e;b1852;;pi_e <=> ;-3.214895047684769;-3.1777100216723975 +EX_pyr_e;b1852;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1852;;succ_e --> ;0.0;0.0 +FBA;b1852;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.140764901036372 +FBP;b1852;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1852;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1852;;for_c --> for_e;0.0;0.0 +FRD7;b1852;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1852;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1852;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;6.871333415503454 +FUMt2_2;b1852;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1852;;g6p_c + nadp_c --> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b1852;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;17.70372507934552 +GLCpts;b1852;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1852;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22087706324017306 +GLNabc;b1852;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1852;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.489324150823243 +GLUN;b1852;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1852;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1852;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1852;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b1852;;h2o_e <=> h2o_c;-29.175827135565836;-29.53235437915348 +ICDHyr;b1852;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;7.803301595127319 +ICL;b1852;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1852;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1852;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1852;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1852;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;6.871333415503454 +ME1;b1852;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1852;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1852;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;37.61134286506643 +NADTRHD;b1852;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1852;;nh4_e <=> nh4_c;4.765319193197444;4.7102012140634155 +O2t;b1852;;o2_e <=> o2_c;21.799492655998886;22.24133814028494 +PDH;b1852;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.040701116486412 +PFK;b1852;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.140764901036372 +PFL;b1852;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1852;;g6p_c <=> f6p_c;4.860861146496871;9.82291827155168 +PGK;b1852;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-17.70372507934552 +PGL;b1852;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b1852;;2pg_c <=> 3pg_c;-14.716139568742859;-16.411460368327536 +PIt2r;b1852;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1777100216723975 +PPC;b1852;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.4753434197146587 +PPCK;b1852;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1852;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1852;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1852;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.4877114596493457 +PYRt2;b1852;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1852;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.6209090068714763 +RPI;b1852;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.6209090068714764 +SUCCt2_2;b1852;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1852;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1852;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;6.871333415503454 +SUCOAS;b1852;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-6.871333415503454 +TALA;b1852;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.15453620107026592 +THD2;b1852;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;7.9396959705831085 +TKT1;b1852;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.1545362010702659 +TKT2;b1852;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.4663728058012104 +TPI;b1852;;dhap_c <=> g3p_c;7.477381962160304;9.140764901036372 +ACALD;b1779;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1779;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1779;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1779;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;-1.7390192571944755e-16 +ACONTb;b1779;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;-1.7390192571944758e-16 +ACt2r;b1779;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1779;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.6453846153846129 +AKGDH;b1779;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b1779;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1779;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1779;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1779;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;9.68076923076922 +Biomass_Ecoli_core;b1779;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;4.5720105671090073e-17 +CO2t;b1779;;co2_e <=> co2_c;-22.809833310205086;-3.8723076923076882 +CS;b1779;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;-1.7390192571944753e-16 +CYTBD;b1779;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;7.744615384615376 +D_LACt2;b1779;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1779;;2pg_c <=> h2o_c + pep_c;14.716139568742859;-6.839727808395076e-17 +ETOHt2r;b1779;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1779;;ac_e --> ;0.0;0.0 +EX_acald_e;b1779;;acald_e --> ;0.0;0.0 +EX_akg_e;b1779;;akg_e --> ;0.0;0.0 +EX_co2_e;b1779;;co2_e <=> ;22.809833310205086;3.8723076923076882 +EX_etoh_e;b1779;;etoh_e --> ;0.0;0.0 +EX_for_e;b1779;;for_e --> ;0.0;0.0 +EX_fru_e;b1779;;fru_e --> ;0.0;0.0 +EX_fum_e;b1779;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1779;;glc__D_e <=> ;-10.0;-0.6453846153846143 +EX_gln__L_e;b1779;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1779;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1779;;h_e <=> ;17.530865429786523;0.0 +EX_h2o_e;b1779;;h2o_e <=> ;29.175827135565836;3.872307692307676 +EX_lac__D_e;b1779;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1779;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1779;;nh4_e <=> ;-4.765319193197444;-3.0613068465124946e-16 +EX_o2_e;b1779;;o2_e <=> ;-21.799492655998886;-3.872307692307687 +EX_pi_e;b1779;;pi_e <=> ;-3.214895047684769;8.637187419524205e-15 +EX_pyr_e;b1779;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1779;;succ_e --> ;0.0;0.0 +FBA;b1779;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;-0.6453846153846177 +FBP;b1779;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.6453846153846179 +FORt2;b1779;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1779;;for_c --> for_e;0.0;0.0 +FRD7;b1779;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1779;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1779;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;2.1965441388078088e-16 +FUMt2_2;b1779;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1779;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;3.8723076923076887 +GAPD;b1779;;g3p_c + nad_c + pi_c --> 13dpg_c + h_c + nadh_c;16.023526143167626;0.0 +GLCpts;b1779;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.645384615384614 +GLNS;b1779;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;1.169063102009773e-17 +GLNabc;b1779;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1779;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-2.376119611832222e-16 +GLUN;b1779;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1779;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1779;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1779;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;3.8723076923076887 +H2Ot;b1779;;h2o_e <=> h2o_c;-29.175827135565836;-3.872307692307676 +ICDHyr;b1779;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;7.47099446372644e-16 +ICL;b1779;;icit_c --> glx_c + succ_c;0.0;-9.210013720920916e-16 +LDH_D;b1779;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1779;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-9.210013720920916e-16 +MALt2_2;b1779;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1779;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-7.013469582113107e-16 +ME1;b1779;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1779;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1779;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;7.744615384615374 +NADTRHD;b1779;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;7.74461538461538 +NH4t;b1779;;nh4_e <=> nh4_c;4.765319193197444;2.493025922033199e-16 +O2t;b1779;;o2_e <=> o2_c;21.799492655998886;3.872307692307687 +PDH;b1779;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b1779;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.0 +PFL;b1779;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1779;;g6p_c <=> f6p_c;4.860861146496871;-3.2269230769230766 +PGK;b1779;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;0.0 +PGL;b1779;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;3.872307692307689 +PGM;b1779;;2pg_c <=> 3pg_c;-14.716139568742859;6.839727808395074e-17 +PIt2r;b1779;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;-8.637187419524205e-15 +PPC;b1779;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0 +PPCK;b1779;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;-6.091331452944002e-16 +PPS;b1779;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.6453846153846129 +PTAr;b1779;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1779;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b1779;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1779;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.581538461538459 +RPI;b1779;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-1.2907692307692298 +SUCCt2_2;b1779;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1779;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1779;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;2.196544138807808e-16 +SUCOAS;b1779;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-1.1406557859728724e-15 +TALA;b1779;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.2907692307692296 +THD2;b1779;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1779;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.2907692307692296 +TKT2;b1779;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.2907692307692296 +TPI;b1779;;dhap_c <=> g3p_c;7.477381962160304;-0.6453846153846177 +ACALD;b1621;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1621;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1621;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1621;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350344 +ACONTb;b1621;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350345 +ACt2r;b1621;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1621;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1621;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482106 +AKGt2r;b1621;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1621;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1621;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1621;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454 +Biomass_Ecoli_core;b1621;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306 +CO2t;b1621;;co2_e <=> co2_c;-22.809833310205086;-22.809833310205 +CS;b1621;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350344 +CYTBD;b1621;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.598985311997595 +D_LACt2;b1621;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1621;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742845 +ETOHt2r;b1621;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1621;;ac_e --> ;0.0;0.0 +EX_acald_e;b1621;;acald_e --> ;0.0;0.0 +EX_akg_e;b1621;;akg_e --> ;0.0;0.0 +EX_co2_e;b1621;;co2_e <=> ;22.809833310205086;22.809833310205 +EX_etoh_e;b1621;;etoh_e --> ;0.0;0.0 +EX_for_e;b1621;;for_e --> ;0.0;0.0 +EX_fru_e;b1621;;fru_e --> ;0.0;0.0 +EX_fum_e;b1621;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1621;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1621;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1621;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1621;;h_e <=> ;17.530865429786523;17.530865429787013 +EX_h2o_e;b1621;;h2o_e <=> ;29.175827135565836;29.175827135565843 +EX_lac__D_e;b1621;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1621;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1621;;nh4_e <=> ;-4.765319193197444;-4.76531919319746 +EX_o2_e;b1621;;o2_e <=> ;-21.799492655998886;-21.799492655998794 +EX_pi_e;b1621;;pi_e <=> ;-3.214895047684769;-3.2148950476847915 +EX_pyr_e;b1621;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1621;;succ_e --> ;0.0;0.0 +FBA;b1621;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160297 +FBP;b1621;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1621;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1621;;for_c --> for_e;0.0;0.0 +FRD7;b1621;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1621;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1621;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.0643756614821065 +FUMt2_2;b1621;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1621;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574655 +GAPD;b1621;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.02352614316762 +GLCpts;b1621;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000009 +GLNS;b1621;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182767 +GLNabc;b1621;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1621;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865631 +GLUN;b1621;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1621;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1621;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1621;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574654 +H2Ot;b1621;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565843 +ICDHyr;b1621;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350345 +ICL;b1621;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1621;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1621;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1621;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1621;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482108 +ME1;b1621;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1621;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1621;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515485 +NADTRHD;b1621;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1621;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197457 +O2t;b1621;;o2_e <=> o2_c;21.799492655998886;21.799492655998794 +PDH;b1621;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166629 +PFK;b1621;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160302 +PFL;b1621;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1621;;g6p_c <=> f6p_c;4.860861146496871;4.8608611464968465 +PGK;b1621;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316762 +PGL;b1621;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574655 +PGM;b1621;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742845 +PIt2r;b1621;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847915 +PPC;b1621;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368733 +PPCK;b1621;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1621;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1621;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1621;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.75817744410679 +PYRt2;b1621;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1621;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075276 +RPI;b1621;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067127 +SUCCt2_2;b1621;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1621;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1621;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482106 +SUCOAS;b1621;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482106 +TALA;b1621;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615659 +THD2;b1621;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1621;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615656 +TKT2;b1621;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459624 +TPI;b1621;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160297 +ACALD;b1101;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1101;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1101;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1101;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1101;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1101;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1101;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1101;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1101;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1101;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1101;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1101;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1101;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1101;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1101;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1101;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1101;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1101;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1101;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1101;;ac_e --> ;0.0;0.0 +EX_acald_e;b1101;;acald_e --> ;0.0;0.0 +EX_akg_e;b1101;;akg_e --> ;0.0;0.0 +EX_co2_e;b1101;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1101;;etoh_e --> ;0.0;0.0 +EX_for_e;b1101;;for_e --> ;0.0;0.0 +EX_fru_e;b1101;;fru_e --> ;0.0;0.0 +EX_fum_e;b1101;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1101;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1101;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1101;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1101;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1101;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1101;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1101;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1101;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1101;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1101;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1101;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1101;;succ_e --> ;0.0;0.0 +FBA;b1101;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1101;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1101;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1101;;for_c --> for_e;0.0;0.0 +FRD7;b1101;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1101;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1101;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1101;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1101;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1101;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1101;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1101;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1101;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1101;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1101;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1101;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1101;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1101;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1101;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1101;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1101;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1101;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1101;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1101;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1101;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1101;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1101;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1101;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1101;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1101;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1101;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1101;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1101;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1101;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1101;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1101;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1101;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1101;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1101;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1101;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1101;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1101;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1101;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1101;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1101;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1101;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1101;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1101;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1101;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1101;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1101;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1101;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1101;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1101;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1101;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1101;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2417;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2417;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2417;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2417;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2417;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2417;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2417;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2417;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2417;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2417;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2417;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2417;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2417;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2417;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2417;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2417;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2417;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2417;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2417;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2417;;ac_e --> ;0.0;0.0 +EX_acald_e;b2417;;acald_e --> ;0.0;0.0 +EX_akg_e;b2417;;akg_e --> ;0.0;0.0 +EX_co2_e;b2417;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2417;;etoh_e --> ;0.0;0.0 +EX_for_e;b2417;;for_e --> ;0.0;0.0 +EX_fru_e;b2417;;fru_e --> ;0.0;0.0 +EX_fum_e;b2417;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2417;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2417;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2417;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2417;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2417;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2417;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2417;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2417;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2417;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2417;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2417;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2417;;succ_e --> ;0.0;0.0 +FBA;b2417;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2417;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2417;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2417;;for_c --> for_e;0.0;0.0 +FRD7;b2417;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2417;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2417;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2417;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2417;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2417;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2417;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2417;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2417;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2417;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2417;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2417;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2417;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2417;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2417;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2417;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2417;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2417;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2417;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2417;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2417;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2417;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2417;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2417;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2417;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2417;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2417;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2417;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2417;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2417;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2417;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2417;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2417;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2417;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2417;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2417;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2417;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2417;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2417;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2417;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2417;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2417;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2417;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2417;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2417;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2417;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2417;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2417;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2417;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2417;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2417;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2417;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3870;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3870;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3870;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3870;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3870;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3870;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3870;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3870;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3870;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3870;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3870;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3870;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3870;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3870;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3870;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3870;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3870;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3870;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3870;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3870;;ac_e --> ;0.0;0.0 +EX_acald_e;b3870;;acald_e --> ;0.0;0.0 +EX_akg_e;b3870;;akg_e --> ;0.0;0.0 +EX_co2_e;b3870;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3870;;etoh_e --> ;0.0;0.0 +EX_for_e;b3870;;for_e --> ;0.0;0.0 +EX_fru_e;b3870;;fru_e --> ;0.0;0.0 +EX_fum_e;b3870;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3870;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3870;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3870;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3870;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3870;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3870;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3870;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3870;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3870;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3870;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3870;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3870;;succ_e --> ;0.0;0.0 +FBA;b3870;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3870;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3870;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3870;;for_c --> for_e;0.0;0.0 +FRD7;b3870;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3870;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3870;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3870;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3870;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3870;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3870;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3870;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3870;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3870;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3870;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3870;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3870;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3870;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3870;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3870;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3870;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3870;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3870;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3870;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3870;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3870;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3870;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3870;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3870;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3870;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3870;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3870;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3870;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3870;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3870;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3870;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3870;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3870;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3870;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3870;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3870;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3870;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3870;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3870;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3870;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3870;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3870;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3870;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3870;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3870;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3870;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3870;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3870;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3870;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3870;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3870;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1297;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1297;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1297;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1297;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1297;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1297;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1297;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1297;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1297;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1297;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1297;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1297;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1297;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1297;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1297;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1297;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1297;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1297;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1297;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1297;;ac_e --> ;0.0;0.0 +EX_acald_e;b1297;;acald_e --> ;0.0;0.0 +EX_akg_e;b1297;;akg_e --> ;0.0;0.0 +EX_co2_e;b1297;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1297;;etoh_e --> ;0.0;0.0 +EX_for_e;b1297;;for_e --> ;0.0;0.0 +EX_fru_e;b1297;;fru_e --> ;0.0;0.0 +EX_fum_e;b1297;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1297;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1297;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1297;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1297;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1297;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1297;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1297;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1297;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1297;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1297;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1297;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1297;;succ_e --> ;0.0;0.0 +FBA;b1297;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1297;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1297;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1297;;for_c --> for_e;0.0;0.0 +FRD7;b1297;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1297;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1297;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1297;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1297;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1297;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1297;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1297;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1297;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1297;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1297;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1297;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1297;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1297;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1297;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1297;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1297;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1297;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1297;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1297;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1297;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1297;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1297;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1297;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1297;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1297;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1297;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1297;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1297;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1297;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1297;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1297;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1297;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1297;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1297;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1297;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1297;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1297;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1297;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1297;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1297;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1297;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1297;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1297;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1297;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1297;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1297;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1297;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1297;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1297;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1297;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1297;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0809;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0809;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0809;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0809;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0809;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0809;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0809;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0809;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0809;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0809;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0809;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0809;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0809;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0809;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0809;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0809;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0809;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0809;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0809;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0809;;ac_e --> ;0.0;0.0 +EX_acald_e;b0809;;acald_e --> ;0.0;0.0 +EX_akg_e;b0809;;akg_e --> ;0.0;0.0 +EX_co2_e;b0809;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0809;;etoh_e --> ;0.0;0.0 +EX_for_e;b0809;;for_e --> ;0.0;0.0 +EX_fru_e;b0809;;fru_e --> ;0.0;0.0 +EX_fum_e;b0809;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0809;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0809;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0809;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0809;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0809;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0809;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0809;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0809;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0809;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0809;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0809;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0809;;succ_e --> ;0.0;0.0 +FBA;b0809;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0809;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0809;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0809;;for_c --> for_e;0.0;0.0 +FRD7;b0809;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0809;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0809;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0809;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0809;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0809;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0809;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0809;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0809;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0809;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0809;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0809;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0809;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0809;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0809;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0809;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0809;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0809;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0809;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0809;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0809;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0809;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0809;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0809;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0809;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0809;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0809;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0809;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0809;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0809;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0809;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0809;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0809;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0809;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0809;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0809;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0809;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0809;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0809;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0809;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0809;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0809;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0809;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0809;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0809;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0809;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0809;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0809;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0809;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0809;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0809;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0809;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0810;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0810;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0810;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0810;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0810;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0810;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0810;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0810;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0810;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0810;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0810;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0810;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0810;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0810;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0810;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0810;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0810;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0810;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0810;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0810;;ac_e --> ;0.0;0.0 +EX_acald_e;b0810;;acald_e --> ;0.0;0.0 +EX_akg_e;b0810;;akg_e --> ;0.0;0.0 +EX_co2_e;b0810;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0810;;etoh_e --> ;0.0;0.0 +EX_for_e;b0810;;for_e --> ;0.0;0.0 +EX_fru_e;b0810;;fru_e --> ;0.0;0.0 +EX_fum_e;b0810;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0810;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0810;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0810;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0810;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0810;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0810;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0810;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0810;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0810;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0810;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0810;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0810;;succ_e --> ;0.0;0.0 +FBA;b0810;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0810;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0810;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0810;;for_c --> for_e;0.0;0.0 +FRD7;b0810;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0810;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0810;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0810;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0810;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0810;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0810;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0810;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0810;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0810;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0810;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0810;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0810;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0810;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0810;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0810;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0810;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0810;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0810;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0810;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0810;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0810;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0810;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0810;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0810;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0810;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0810;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0810;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0810;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0810;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0810;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0810;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0810;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0810;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0810;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0810;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0810;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0810;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0810;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0810;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0810;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0810;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0810;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0810;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0810;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0810;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0810;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0810;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0810;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0810;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0810;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0810;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0811;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0811;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0811;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0811;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0811;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0811;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0811;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0811;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0811;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0811;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0811;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0811;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0811;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0811;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0811;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0811;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0811;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0811;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0811;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0811;;ac_e --> ;0.0;0.0 +EX_acald_e;b0811;;acald_e --> ;0.0;0.0 +EX_akg_e;b0811;;akg_e --> ;0.0;0.0 +EX_co2_e;b0811;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0811;;etoh_e --> ;0.0;0.0 +EX_for_e;b0811;;for_e --> ;0.0;0.0 +EX_fru_e;b0811;;fru_e --> ;0.0;0.0 +EX_fum_e;b0811;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0811;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0811;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0811;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0811;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0811;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0811;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0811;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0811;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0811;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0811;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0811;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0811;;succ_e --> ;0.0;0.0 +FBA;b0811;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0811;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0811;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0811;;for_c --> for_e;0.0;0.0 +FRD7;b0811;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0811;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0811;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0811;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0811;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0811;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0811;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0811;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0811;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0811;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0811;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0811;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0811;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0811;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0811;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0811;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0811;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0811;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0811;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0811;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0811;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0811;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0811;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0811;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0811;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0811;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0811;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0811;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0811;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0811;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0811;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0811;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0811;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0811;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0811;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0811;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0811;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0811;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0811;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0811;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0811;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0811;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0811;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0811;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0811;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0811;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0811;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0811;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0811;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0811;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0811;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0811;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1761;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1761;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1761;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1761;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.471170359316124 +ACONTb;b1761;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.471170359316125 +ACt2r;b1761;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1761;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1761;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.552607281477905 +AKGt2r;b1761;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1761;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1761;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1761;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.74394391135162 +Biomass_Ecoli_core;b1761;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.851388523346209 +CO2t;b1761;;co2_e <=> co2_c;-22.809833310205086;-23.76873569474045 +CS;b1761;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.471170359316125 +CYTBD;b1761;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;45.5688908457998 +D_LACt2;b1761;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1761;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.955512411018093 +ETOHt2r;b1761;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1761;;ac_e --> ;0.0;0.0 +EX_acald_e;b1761;;acald_e --> ;0.0;0.0 +EX_akg_e;b1761;;akg_e --> ;0.0;0.0 +EX_co2_e;b1761;;co2_e <=> ;22.809833310205086;23.76873569474045 +EX_etoh_e;b1761;;etoh_e --> ;0.0;0.0 +EX_for_e;b1761;;for_e --> ;0.0;0.0 +EX_fru_e;b1761;;fru_e --> ;0.0;0.0 +EX_fum_e;b1761;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1761;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1761;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1761;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1761;;h_e <=> ;17.530865429786523;17.078853778325005 +EX_h2o_e;b1761;;h2o_e <=> ;29.175827135565836;29.970590254203575 +EX_lac__D_e;b1761;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1761;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1761;;nh4_e <=> ;-4.765319193197444;-4.642451340102205 +EX_o2_e;b1761;;o2_e <=> ;-21.799492655998886;-22.784445422899896 +EX_pi_e;b1761;;pi_e <=> ;-3.214895047684769;-3.132002960833728 +EX_pyr_e;b1761;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1761;;succ_e --> ;0.0;0.0 +FBA;b1761;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.645559589382772 +FBP;b1761;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1761;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1761;;for_c --> for_e;0.0;0.0 +FRD7;b1761;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1761;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1761;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.552607281477904 +FUMt2_2;b1761;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1761;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.522692739334265 +GAPD;b1761;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.22918964194402 +GLCpts;b1761;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1761;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;4.642451340102205 +GLNabc;b1761;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1761;;glu__L_c + h2o_c + nadp_c --> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;0.0 +GLUN;b1761;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1761;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;4.424751294682581 +GLUt2r;b1761;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1761;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.522692739334264 +H2Ot;b1761;;h2o_e <=> h2o_c;-29.175827135565836;-29.970590254203575 +ICDHyr;b1761;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.471170359316125 +ICL;b1761;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1761;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1761;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1761;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1761;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.552607281477904 +ME1;b1761;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1761;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1761;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.01628356432189 +NADTRHD;b1761;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1761;;nh4_e <=> nh4_c;4.765319193197444;4.642451340102205 +O2t;b1761;;o2_e <=> o2_c;21.799492655998886;22.784445422899896 +PDH;b1761;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.662004267113048 +PFK;b1761;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.645559589382773 +PFL;b1761;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1761;;g6p_c <=> f6p_c;4.860861146496871;5.302772613379765 +PGK;b1761;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.229189641944025 +PGL;b1761;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.522692739334265 +PGM;b1761;;2pg_c <=> 3pg_c;-14.716139568742859;-14.955512411018093 +PIt2r;b1761;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.132002960833728 +PPC;b1761;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.439738952500888 +PPCK;b1761;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1761;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1761;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1761;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;2.073817676048187 +PYRt2;b1761;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1761;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.4031504223082547 +RPI;b1761;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.1195423170260104 +SUCCt2_2;b1761;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1761;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1761;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.552607281477905 +SUCOAS;b1761;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.552607281477905 +TALA;b1761;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.3552508396181182 +THD2;b1761;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1761;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.355250839618118 +TKT2;b1761;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.0478995826901367 +TPI;b1761;;dhap_c <=> g3p_c;7.477381962160304;7.645559589382772 +ACALD;b1524;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1524;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1524;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1524;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350328 +ACONTb;b1524;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350328 +ACt2r;b1524;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1524;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1524;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482091 +AKGt2r;b1524;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1524;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1524;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1524;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454 +Biomass_Ecoli_core;b1524;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306 +CO2t;b1524;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1524;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350327 +CYTBD;b1524;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199751 +D_LACt2;b1524;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1524;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742825 +ETOHt2r;b1524;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1524;;ac_e --> ;0.0;0.0 +EX_acald_e;b1524;;acald_e --> ;0.0;0.0 +EX_akg_e;b1524;;akg_e --> ;0.0;0.0 +EX_co2_e;b1524;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1524;;etoh_e --> ;0.0;0.0 +EX_for_e;b1524;;for_e --> ;0.0;0.0 +EX_fru_e;b1524;;fru_e --> ;0.0;0.0 +EX_fum_e;b1524;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1524;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1524;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1524;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1524;;h_e <=> ;17.530865429786523;17.530865429786708 +EX_h2o_e;b1524;;h2o_e <=> ;29.175827135565836;29.17582713556576 +EX_lac__D_e;b1524;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1524;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1524;;nh4_e <=> ;-4.765319193197444;-4.765319193197458 +EX_o2_e;b1524;;o2_e <=> ;-21.799492655998886;-21.79949265599875 +EX_pi_e;b1524;;pi_e <=> ;-3.214895047684769;-3.214895047684734 +EX_pyr_e;b1524;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1524;;succ_e --> ;0.0;0.0 +FBA;b1524;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160276 +FBP;b1524;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1524;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1524;;for_c --> for_e;0.0;0.0 +FRD7;b1524;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1524;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1524;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.0643756614820905 +FUMt2_2;b1524;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1524;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574679 +GAPD;b1524;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167597 +GLCpts;b1524;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1524;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182648 +GLNabc;b1524;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1524;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632 +GLUN;b1524;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1524;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1524;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1524;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574678 +H2Ot;b1524;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556576 +ICDHyr;b1524;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350328 +ICL;b1524;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1524;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1524;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1524;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1524;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.0643756614820905 +ME1;b1524;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1524;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1524;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515414 +NADTRHD;b1524;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1524;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1524;;o2_e <=> o2_c;21.799492655998886;21.79949265599875 +PDH;b1524;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916661 +PFK;b1524;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160277 +PFL;b1524;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1524;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496793 +PGK;b1524;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.0235261431676 +PGL;b1524;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574679 +PGM;b1524;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742825 +PIt2r;b1524;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684734 +PPC;b1524;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687308 +PPCK;b1524;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1524;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1524;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1524;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067795 +PYRt2;b1524;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1524;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075445 +RPI;b1524;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671344 +SUCCt2_2;b1524;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1524;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1524;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482091 +SUCOAS;b1524;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482091 +TALA;b1524;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.496983757261574 +THD2;b1524;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1524;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261574 +TKT2;b1524;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459709 +TPI;b1524;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160276 +ACALD;b1812;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1812;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1812;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1812;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1812;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1812;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1812;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1812;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1812;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1812;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1812;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1812;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1812;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1812;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1812;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1812;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1812;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1812;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1812;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1812;;ac_e --> ;0.0;0.0 +EX_acald_e;b1812;;acald_e --> ;0.0;0.0 +EX_akg_e;b1812;;akg_e --> ;0.0;0.0 +EX_co2_e;b1812;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1812;;etoh_e --> ;0.0;0.0 +EX_for_e;b1812;;for_e --> ;0.0;0.0 +EX_fru_e;b1812;;fru_e --> ;0.0;0.0 +EX_fum_e;b1812;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1812;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1812;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1812;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1812;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1812;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1812;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1812;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1812;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1812;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1812;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1812;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1812;;succ_e --> ;0.0;0.0 +FBA;b1812;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1812;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1812;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1812;;for_c --> for_e;0.0;0.0 +FRD7;b1812;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1812;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1812;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1812;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1812;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1812;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1812;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1812;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1812;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1812;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1812;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1812;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1812;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1812;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1812;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1812;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1812;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1812;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1812;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1812;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1812;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1812;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1812;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1812;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1812;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1812;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1812;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1812;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1812;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1812;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1812;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1812;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1812;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1812;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1812;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1812;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1812;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1812;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1812;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1812;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1812;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1812;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1812;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1812;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1812;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1812;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1812;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1812;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1812;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1812;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1812;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1812;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0485;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0485;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0485;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0485;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0485;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0485;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0485;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0485;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0485;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0485;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0485;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0485;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0485;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0485;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0485;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0485;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0485;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0485;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0485;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0485;;ac_e --> ;0.0;0.0 +EX_acald_e;b0485;;acald_e --> ;0.0;0.0 +EX_akg_e;b0485;;akg_e --> ;0.0;0.0 +EX_co2_e;b0485;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0485;;etoh_e --> ;0.0;0.0 +EX_for_e;b0485;;for_e --> ;0.0;0.0 +EX_fru_e;b0485;;fru_e --> ;0.0;0.0 +EX_fum_e;b0485;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0485;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0485;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0485;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0485;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0485;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0485;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0485;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0485;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0485;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0485;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0485;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0485;;succ_e --> ;0.0;0.0 +FBA;b0485;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0485;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0485;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0485;;for_c --> for_e;0.0;0.0 +FRD7;b0485;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0485;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0485;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0485;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0485;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0485;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0485;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0485;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0485;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0485;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0485;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0485;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0485;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0485;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0485;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0485;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0485;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0485;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0485;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0485;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0485;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0485;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0485;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0485;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0485;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0485;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0485;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0485;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0485;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0485;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0485;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0485;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0485;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0485;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0485;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0485;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0485;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0485;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0485;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0485;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0485;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0485;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0485;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0485;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0485;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0485;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0485;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0485;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0485;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0485;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0485;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0485;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3213;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3213;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3213;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3213;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3213;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3213;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3213;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3213;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3213;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3213;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3213;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3213;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3213;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3213;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3213;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3213;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3213;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3213;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3213;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3213;;ac_e --> ;0.0;0.0 +EX_acald_e;b3213;;acald_e --> ;0.0;0.0 +EX_akg_e;b3213;;akg_e --> ;0.0;0.0 +EX_co2_e;b3213;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3213;;etoh_e --> ;0.0;0.0 +EX_for_e;b3213;;for_e --> ;0.0;0.0 +EX_fru_e;b3213;;fru_e --> ;0.0;0.0 +EX_fum_e;b3213;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3213;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3213;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3213;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3213;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3213;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3213;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3213;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3213;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3213;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3213;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3213;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3213;;succ_e --> ;0.0;0.0 +FBA;b3213;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3213;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3213;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3213;;for_c --> for_e;0.0;0.0 +FRD7;b3213;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3213;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3213;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3213;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3213;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3213;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3213;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3213;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3213;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3213;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3213;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3213;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3213;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3213;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3213;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3213;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3213;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3213;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3213;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3213;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3213;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3213;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3213;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3213;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3213;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3213;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3213;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3213;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3213;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3213;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3213;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3213;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3213;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3213;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3213;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3213;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3213;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3213;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3213;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3213;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3213;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3213;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3213;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3213;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3213;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3213;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3213;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3213;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3213;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3213;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3213;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3213;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3212;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3212;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3212;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3212;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3212;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3212;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3212;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3212;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3212;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3212;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3212;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3212;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3212;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3212;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3212;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3212;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3212;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3212;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3212;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3212;;ac_e --> ;0.0;0.0 +EX_acald_e;b3212;;acald_e --> ;0.0;0.0 +EX_akg_e;b3212;;akg_e --> ;0.0;0.0 +EX_co2_e;b3212;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3212;;etoh_e --> ;0.0;0.0 +EX_for_e;b3212;;for_e --> ;0.0;0.0 +EX_fru_e;b3212;;fru_e --> ;0.0;0.0 +EX_fum_e;b3212;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3212;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3212;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3212;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3212;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3212;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3212;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3212;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3212;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3212;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3212;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3212;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3212;;succ_e --> ;0.0;0.0 +FBA;b3212;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3212;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3212;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3212;;for_c --> for_e;0.0;0.0 +FRD7;b3212;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3212;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3212;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3212;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3212;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3212;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3212;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3212;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3212;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3212;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3212;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3212;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3212;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3212;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3212;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3212;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3212;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3212;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3212;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3212;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3212;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3212;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3212;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3212;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3212;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3212;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3212;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3212;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3212;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3212;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3212;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3212;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3212;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3212;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3212;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3212;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3212;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3212;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3212;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3212;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3212;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3212;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3212;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3212;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3212;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3212;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3212;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3212;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3212;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3212;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3212;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3212;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4077;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4077;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4077;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4077;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4077;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4077;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4077;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4077;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4077;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4077;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4077;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4077;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4077;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4077;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4077;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4077;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4077;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4077;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4077;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4077;;ac_e --> ;0.0;0.0 +EX_acald_e;b4077;;acald_e --> ;0.0;0.0 +EX_akg_e;b4077;;akg_e --> ;0.0;0.0 +EX_co2_e;b4077;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4077;;etoh_e --> ;0.0;0.0 +EX_for_e;b4077;;for_e --> ;0.0;0.0 +EX_fru_e;b4077;;fru_e --> ;0.0;0.0 +EX_fum_e;b4077;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4077;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4077;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4077;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4077;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4077;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4077;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4077;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4077;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4077;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4077;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4077;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4077;;succ_e --> ;0.0;0.0 +FBA;b4077;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4077;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4077;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4077;;for_c --> for_e;0.0;0.0 +FRD7;b4077;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4077;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4077;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4077;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4077;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4077;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4077;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4077;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4077;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4077;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4077;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4077;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4077;;glu__L_e + h_e --> glu__L_c + h_c;0.0;0.0 +GND;b4077;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4077;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4077;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4077;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4077;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4077;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4077;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4077;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4077;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4077;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4077;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4077;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4077;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4077;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4077;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4077;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4077;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4077;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4077;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4077;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4077;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4077;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4077;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4077;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4077;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4077;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4077;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4077;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4077;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4077;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4077;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4077;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4077;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4077;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4077;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4077;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4077;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4077;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4077;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2029;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2029;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2029;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2029;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;7.803301595127319 +ACONTb;b2029;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;7.80330159512732 +ACt2r;b2029;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2029;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2029;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;6.871333415503454 +AKGt2r;b2029;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2029;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2029;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2029;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;41.35354605121254 +Biomass_Ecoli_core;b2029;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.863813309504001 +CO2t;b2029;;co2_e <=> co2_c;-22.809833310205086;-23.239992707402525 +CS;b2029;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;7.803301595127319 +CYTBD;b2029;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.48267628056989 +D_LACt2;b2029;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2029;;2pg_c <=> h2o_c + pep_c;14.716139568742859;16.411460368327536 +ETOHt2r;b2029;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2029;;ac_e --> ;0.0;0.0 +EX_acald_e;b2029;;acald_e --> ;0.0;0.0 +EX_akg_e;b2029;;akg_e --> ;0.0;0.0 +EX_co2_e;b2029;;co2_e <=> ;22.809833310205086;23.239992707402525 +EX_etoh_e;b2029;;etoh_e --> ;0.0;0.0 +EX_for_e;b2029;;for_e --> ;0.0;0.0 +EX_fru_e;b2029;;fru_e --> ;0.0;0.0 +EX_fum_e;b2029;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2029;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2029;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2029;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2029;;h_e <=> ;17.530865429786523;17.328094988650292 +EX_h2o_e;b2029;;h2o_e <=> ;29.175827135565836;29.53235437915348 +EX_lac__D_e;b2029;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2029;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2029;;nh4_e <=> ;-4.765319193197444;-4.7102012140634155 +EX_o2_e;b2029;;o2_e <=> ;-21.799492655998886;-22.24133814028494 +EX_pi_e;b2029;;pi_e <=> ;-3.214895047684769;-3.1777100216723975 +EX_pyr_e;b2029;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2029;;succ_e --> ;0.0;0.0 +FBA;b2029;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.140764901036372 +FBP;b2029;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2029;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2029;;for_c --> for_e;0.0;0.0 +FRD7;b2029;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2029;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2029;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;6.871333415503454 +FUMt2_2;b2029;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2029;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2029;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;17.70372507934552 +GLCpts;b2029;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2029;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22087706324017306 +GLNabc;b2029;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2029;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.489324150823243 +GLUN;b2029;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2029;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2029;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2029;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2029;;h2o_e <=> h2o_c;-29.175827135565836;-29.53235437915348 +ICDHyr;b2029;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;7.803301595127319 +ICL;b2029;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2029;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2029;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2029;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2029;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;6.871333415503454 +ME1;b2029;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2029;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2029;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;37.61134286506643 +NADTRHD;b2029;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2029;;nh4_e <=> nh4_c;4.765319193197444;4.7102012140634155 +O2t;b2029;;o2_e <=> o2_c;21.799492655998886;22.24133814028494 +PDH;b2029;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.040701116486412 +PFK;b2029;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.140764901036372 +PFL;b2029;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2029;;g6p_c <=> f6p_c;4.860861146496871;9.82291827155168 +PGK;b2029;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-17.70372507934552 +PGL;b2029;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2029;;2pg_c <=> 3pg_c;-14.716139568742859;-16.411460368327536 +PIt2r;b2029;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1777100216723975 +PPC;b2029;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.4753434197146587 +PPCK;b2029;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2029;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2029;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2029;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.4877114596493457 +PYRt2;b2029;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2029;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.6209090068714763 +RPI;b2029;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.6209090068714764 +SUCCt2_2;b2029;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2029;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2029;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;6.871333415503454 +SUCOAS;b2029;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-6.871333415503454 +TALA;b2029;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.15453620107026592 +THD2;b2029;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;7.9396959705831085 +TKT1;b2029;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.1545362010702659 +TKT2;b2029;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.4663728058012104 +TPI;b2029;;dhap_c <=> g3p_c;7.477381962160304;9.140764901036372 +ACALD;b0875;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0875;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0875;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0875;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350332 +ACONTb;b0875;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325 +ACt2r;b0875;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0875;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0875;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096 +AKGt2r;b0875;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0875;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0875;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0875;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451748 +Biomass_Ecoli_core;b0875;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684311 +CO2t;b0875;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204976 +CS;b0875;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350331 +CYTBD;b0875;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754 +D_LACt2;b0875;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0875;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283 +ETOHt2r;b0875;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0875;;ac_e --> ;0.0;0.0 +EX_acald_e;b0875;;acald_e --> ;0.0;0.0 +EX_akg_e;b0875;;akg_e --> ;0.0;0.0 +EX_co2_e;b0875;;co2_e <=> ;22.809833310205086;22.809833310204976 +EX_etoh_e;b0875;;etoh_e --> ;0.0;0.0 +EX_for_e;b0875;;for_e --> ;0.0;0.0 +EX_fru_e;b0875;;fru_e --> ;0.0;0.0 +EX_fum_e;b0875;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0875;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0875;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0875;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0875;;h_e <=> ;17.530865429786523;17.530865429786658 +EX_h2o_e;b0875;;h2o_e <=> ;29.175827135565836;29.175827135565804 +EX_lac__D_e;b0875;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0875;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0875;;nh4_e <=> ;-4.765319193197444;-4.76531919319746 +EX_o2_e;b0875;;o2_e <=> ;-21.799492655998886;-21.799492655998765 +EX_pi_e;b0875;;pi_e <=> ;-3.214895047684769;-3.2148950476847737 +EX_pyr_e;b0875;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0875;;succ_e --> ;0.0;0.0 +FBA;b0875;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.4773819621602815 +FBP;b0875;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0875;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0875;;for_c --> for_e;0.0;0.0 +FRD7;b0875;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0875;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0875;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482096 +FUMt2_2;b0875;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0875;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574662 +GAPD;b0875;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604 +GLCpts;b0875;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0875;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182779 +GLNabc;b0875;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0875;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632 +GLUN;b0875;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0875;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0875;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0875;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574661 +H2Ot;b0875;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565804 +ICDHyr;b0875;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350332 +ICL;b0875;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0875;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0875;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0875;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0875;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482096 +ME1;b0875;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0875;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0875;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0875;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0875;;nh4_e <=> nh4_c;4.765319193197444;4.76531919319746 +O2t;b0875;;o2_e <=> o2_c;21.799492655998886;21.799492655998765 +PDH;b0875;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166617 +PFK;b0875;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160282 +PFL;b0875;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0875;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496811 +PGK;b0875;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608 +PGL;b0875;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.9599849445746615 +PGM;b0875;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283 +PIt2r;b0875;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847737 +PPC;b0875;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368731 +PPCK;b0875;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0875;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0875;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0875;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067861 +PYRt2;b0875;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0875;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075316 +RPI;b0875;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671295 +SUCCt2_2;b0875;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0875;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0875;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097 +SUCOAS;b0875;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097 +TALA;b0875;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615678 +THD2;b0875;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0875;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615676 +TKT2;b0875;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459647 +TPI;b0875;;dhap_c <=> g3p_c;7.477381962160304;7.4773819621602815 +ACALD;b1136;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1136;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1136;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1136;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;10.000000000000034 +ACONTb;b1136;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;10.000000000000034 +ACt2r;b1136;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1136;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1136;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b1136;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1136;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1136;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;75.00000000000034 +ATPS4r;b1136;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;55.00000000000006 +Biomass_Ecoli_core;b1136;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;-3.642223560848925e-15 +CO2t;b1136;;co2_e <=> co2_c;-22.809833310205086;-20.000000000000018 +CS;b1136;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;10.00000000000003 +CYTBD;b1136;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;50.00000000000007 +D_LACt2;b1136;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1136;;2pg_c <=> h2o_c + pep_c;14.716139568742859;20.00000000000003 +ETOHt2r;b1136;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1136;;ac_e --> ;0.0;0.0 +EX_acald_e;b1136;;acald_e --> ;0.0;0.0 +EX_akg_e;b1136;;akg_e --> ;0.0;0.0 +EX_co2_e;b1136;;co2_e <=> ;22.809833310205086;20.000000000000018 +EX_etoh_e;b1136;;etoh_e --> ;0.0;0.0 +EX_for_e;b1136;;for_e --> ;0.0;0.0 +EX_fru_e;b1136;;fru_e --> ;0.0;0.0 +EX_fum_e;b1136;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1136;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1136;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1136;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1136;;h_e <=> ;17.530865429786523;20.000000000000068 +EX_h2o_e;b1136;;h2o_e <=> ;29.175827135565836;30.00000000000001 +EX_lac__D_e;b1136;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1136;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1136;;nh4_e <=> ;-4.765319193197444;1.9860316632597014e-14 +EX_o2_e;b1136;;o2_e <=> ;-21.799492655998886;-25.000000000000036 +EX_pi_e;b1136;;pi_e <=> ;-3.214895047684769;-2.1139181008574163e-15 +EX_pyr_e;b1136;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1136;;succ_e --> ;0.0;10.000000000000052 +FBA;b1136;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;10.000000000000014 +FBP;b1136;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1136;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1136;;for_c --> for_e;0.0;0.0 +FRD7;b1136;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1136;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1136;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-1.646233710882624e-14 +FUMt2_2;b1136;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1136;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;-3.117390560978087e-14 +GAPD;b1136;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;20.000000000000025 +GLCpts;b1136;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1136;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;-9.3131656450907e-16 +GLNabc;b1136;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1136;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;1.8929000068087943e-14 +GLUN;b1136;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1136;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1136;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1136;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;-3.1173905609780864e-14 +H2Ot;b1136;;h2o_e <=> h2o_c;-29.175827135565836;-30.00000000000001 +ICDHyr;b1136;;icit_c + nadp_c --> akg_c + co2_c + nadph_c;6.007249575350396;0.0 +ICL;b1136;;icit_c --> glx_c + succ_c;0.0;10.000000000000034 +LDH_D;b1136;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1136;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;10.000000000000034 +MALt2_2;b1136;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1136;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;10.000000000000018 +ME1;b1136;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1136;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1136;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;50.00000000000008 +NADTRHD;b1136;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1136;;nh4_e <=> nh4_c;4.765319193197444;-1.9860316632597014e-14 +O2t;b1136;;o2_e <=> o2_c;21.799492655998886;25.000000000000036 +PDH;b1136;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;20.000000000000046 +PFK;b1136;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;10.000000000000016 +PFL;b1136;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1136;;g6p_c <=> f6p_c;4.860861146496871;10.000000000000034 +PGK;b1136;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-20.000000000000025 +PGL;b1136;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;-3.117390560978087e-14 +PGM;b1136;;2pg_c <=> 3pg_c;-14.716139568742859;-20.00000000000003 +PIt2r;b1136;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.1139181008574163e-15 +PPC;b1136;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0 +PPCK;b1136;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1136;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1136;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1136;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;10.000000000000036 +PYRt2;b1136;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1136;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-2.0888979484461287e-14 +RPI;b1136;;r5p_c <=> ru5p__D_c;-2.2815030940671064;1.028492612531958e-14 +SUCCt2_2;b1136;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1136;;h_e + succ_c --> h_c + succ_e;0.0;10.000000000000052 +SUCDi;b1136;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;-1.5948213258617017e-14 +SUCOAS;b1136;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-2.275026620207604e-15 +TALA;b1136;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-1.2464114115036669e-14 +THD2;b1136;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1136;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-1.2464114115036668e-14 +TKT2;b1136;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-8.42486536942462e-15 +TPI;b1136;;dhap_c <=> g3p_c;7.477381962160304;10.000000000000014 +ACALD;b4015;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4015;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4015;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4015;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4015;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4015;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4015;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4015;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.0643756614820985 +AKGt2r;b4015;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4015;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4015;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4015;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451746 +Biomass_Ecoli_core;b4015;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684313 +CO2t;b4015;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4015;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350331 +CYTBD;b4015;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4015;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4015;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742824 +ETOHt2r;b4015;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4015;;ac_e --> ;0.0;0.0 +EX_acald_e;b4015;;acald_e --> ;0.0;0.0 +EX_akg_e;b4015;;akg_e --> ;0.0;0.0 +EX_co2_e;b4015;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4015;;etoh_e --> ;0.0;0.0 +EX_for_e;b4015;;for_e --> ;0.0;0.0 +EX_fru_e;b4015;;fru_e --> ;0.0;0.0 +EX_fum_e;b4015;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4015;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4015;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4015;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4015;;h_e <=> ;17.530865429786523;17.53086542978669 +EX_h2o_e;b4015;;h2o_e <=> ;29.175827135565836;29.17582713556576 +EX_lac__D_e;b4015;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4015;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4015;;nh4_e <=> ;-4.765319193197444;-4.76531919319746 +EX_o2_e;b4015;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4015;;pi_e <=> ;-3.214895047684769;-3.214895047684771 +EX_pyr_e;b4015;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4015;;succ_e --> ;0.0;0.0 +FBA;b4015;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160281 +FBP;b4015;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4015;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4015;;for_c --> for_e;0.0;0.0 +FRD7;b4015;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4015;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4015;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482101 +FUMt2_2;b4015;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4015;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574662 +GAPD;b4015;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167597 +GLCpts;b4015;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4015;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182784 +GLNabc;b4015;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4015;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632 +GLUN;b4015;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4015;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4015;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4015;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574661 +H2Ot;b4015;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556576 +ICDHyr;b4015;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4015;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4015;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4015;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-6.379285303446807e-15 +MALt2_2;b4015;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4015;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482095 +ME1;b4015;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4015;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4015;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051542 +NADTRHD;b4015;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4015;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197461 +O2t;b4015;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4015;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166608 +PFK;b4015;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.4773819621602815 +PFL;b4015;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4015;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496811 +PGK;b4015;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.0235261431676 +PGL;b4015;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.9599849445746615 +PGM;b4015;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742824 +PIt2r;b4015;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684771 +PPC;b4015;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687316 +PPCK;b4015;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4015;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4015;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4015;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067786 +PYRt2;b4015;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4015;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507532 +RPI;b4015;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671295 +SUCCt2_2;b4015;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4015;;h_e + succ_c --> h_c + succ_e;0.0;-2.3922319887925524e-15 +SUCDi;b4015;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482101 +SUCOAS;b4015;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.0643756614820985 +TALA;b4015;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615676 +THD2;b4015;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4015;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615676 +TKT2;b4015;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459642 +TPI;b4015;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160281 +ACALD;b2133;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2133;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2133;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2133;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2133;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2133;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2133;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2133;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2133;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2133;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2133;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2133;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2133;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2133;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2133;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2133;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2133;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2133;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2133;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2133;;ac_e --> ;0.0;0.0 +EX_acald_e;b2133;;acald_e --> ;0.0;0.0 +EX_akg_e;b2133;;akg_e --> ;0.0;0.0 +EX_co2_e;b2133;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2133;;etoh_e --> ;0.0;0.0 +EX_for_e;b2133;;for_e --> ;0.0;0.0 +EX_fru_e;b2133;;fru_e --> ;0.0;0.0 +EX_fum_e;b2133;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2133;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2133;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2133;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2133;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2133;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2133;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2133;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2133;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2133;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2133;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2133;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2133;;succ_e --> ;0.0;0.0 +FBA;b2133;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2133;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2133;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2133;;for_c --> for_e;0.0;0.0 +FRD7;b2133;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2133;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2133;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2133;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2133;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2133;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2133;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2133;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2133;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2133;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2133;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2133;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2133;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2133;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2133;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2133;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2133;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2133;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2133;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2133;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2133;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2133;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2133;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2133;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2133;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2133;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2133;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2133;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2133;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2133;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2133;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2133;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2133;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2133;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2133;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2133;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2133;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2133;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2133;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2133;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2133;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2133;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2133;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2133;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2133;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2133;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2133;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2133;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2133;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2133;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2133;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2133;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1380;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1380;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1380;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1380;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1380;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1380;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1380;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1380;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1380;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1380;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1380;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1380;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1380;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1380;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1380;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1380;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1380;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1380;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1380;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1380;;ac_e --> ;0.0;0.0 +EX_acald_e;b1380;;acald_e --> ;0.0;0.0 +EX_akg_e;b1380;;akg_e --> ;0.0;0.0 +EX_co2_e;b1380;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1380;;etoh_e --> ;0.0;0.0 +EX_for_e;b1380;;for_e --> ;0.0;0.0 +EX_fru_e;b1380;;fru_e --> ;0.0;0.0 +EX_fum_e;b1380;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1380;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1380;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1380;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1380;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1380;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1380;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1380;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1380;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1380;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1380;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1380;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1380;;succ_e --> ;0.0;0.0 +FBA;b1380;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1380;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1380;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1380;;for_c --> for_e;0.0;0.0 +FRD7;b1380;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1380;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1380;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1380;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1380;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1380;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1380;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1380;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1380;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1380;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1380;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1380;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1380;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1380;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1380;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1380;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1380;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1380;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1380;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1380;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1380;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1380;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1380;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1380;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1380;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1380;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1380;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1380;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1380;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1380;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1380;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1380;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1380;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1380;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1380;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1380;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1380;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1380;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1380;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1380;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1380;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1380;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1380;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1380;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1380;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1380;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1380;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1380;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1380;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1380;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1380;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1380;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4014;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4014;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4014;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4014;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4014;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4014;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4014;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4014;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4014;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4014;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4014;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4014;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4014;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4014;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4014;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4014;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4014;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4014;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4014;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4014;;ac_e --> ;0.0;0.0 +EX_acald_e;b4014;;acald_e --> ;0.0;0.0 +EX_akg_e;b4014;;akg_e --> ;0.0;0.0 +EX_co2_e;b4014;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4014;;etoh_e --> ;0.0;0.0 +EX_for_e;b4014;;for_e --> ;0.0;0.0 +EX_fru_e;b4014;;fru_e --> ;0.0;0.0 +EX_fum_e;b4014;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4014;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4014;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4014;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4014;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4014;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4014;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4014;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4014;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4014;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4014;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4014;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4014;;succ_e --> ;0.0;0.0 +FBA;b4014;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4014;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4014;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4014;;for_c --> for_e;0.0;0.0 +FRD7;b4014;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4014;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4014;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4014;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4014;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4014;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4014;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4014;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4014;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4014;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4014;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4014;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4014;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4014;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4014;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4014;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4014;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4014;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4014;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4014;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4014;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4014;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4014;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4014;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4014;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4014;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4014;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4014;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4014;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4014;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4014;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4014;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4014;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4014;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4014;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4014;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4014;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4014;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4014;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4014;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4014;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4014;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4014;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4014;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4014;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4014;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4014;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4014;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4014;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4014;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4014;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4014;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2976;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2976;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2976;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2976;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2976;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2976;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2976;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2976;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2976;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2976;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2976;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2976;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2976;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2976;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2976;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2976;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2976;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2976;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2976;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2976;;ac_e --> ;0.0;0.0 +EX_acald_e;b2976;;acald_e --> ;0.0;0.0 +EX_akg_e;b2976;;akg_e --> ;0.0;0.0 +EX_co2_e;b2976;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2976;;etoh_e --> ;0.0;0.0 +EX_for_e;b2976;;for_e --> ;0.0;0.0 +EX_fru_e;b2976;;fru_e --> ;0.0;0.0 +EX_fum_e;b2976;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2976;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2976;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2976;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2976;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2976;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2976;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2976;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2976;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2976;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2976;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2976;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2976;;succ_e --> ;0.0;0.0 +FBA;b2976;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2976;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2976;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2976;;for_c --> for_e;0.0;0.0 +FRD7;b2976;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2976;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2976;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2976;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2976;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2976;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2976;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2976;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2976;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2976;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2976;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2976;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2976;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2976;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2976;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2976;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2976;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2976;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2976;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2976;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2976;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2976;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2976;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2976;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2976;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2976;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2976;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2976;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2976;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2976;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2976;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2976;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2976;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2976;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2976;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2976;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2976;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2976;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2976;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2976;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2976;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2976;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2976;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2976;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2976;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2976;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2976;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2976;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2976;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2976;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2976;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2976;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3236;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;1.7902733216877847e-16 +ACALDt;b3236;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3236;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3236;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;8.339761944486769 +ACONTb;b3236;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;8.33976194448677 +ACt2r;b3236;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3236;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.674637143672371 +AKGDH;b3236;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;7.448785511861677 +AKGt2r;b3236;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3236;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-2.032533356393427e-17 +ATPM;b3236;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3236;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;49.26773551053178 +Biomass_Ecoli_core;b3236;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8258192905969891 +CO2t;b3236;;co2_e <=> co2_c;-22.809833310205086;-24.856847178999885 +CS;b3236;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;8.339761944486769 +CYTBD;b3236;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;47.80423499428138 +D_LACt2;b3236;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3236;;2pg_c <=> h2o_c + pep_c;14.716139568742859;16.569298921072935 +ETOHt2r;b3236;;etoh_e + h_e <=> etoh_c + h_c;0.0;1.790273321687785e-16 +EX_ac_e;b3236;;ac_e --> ;0.0;0.0 +EX_acald_e;b3236;;acald_e --> ;0.0;0.0 +EX_akg_e;b3236;;akg_e --> ;0.0;0.0 +EX_co2_e;b3236;;co2_e <=> ;22.809833310205086;24.856847178999885 +EX_etoh_e;b3236;;etoh_e --> ;0.0;0.0 +EX_for_e;b3236;;for_e --> ;0.0;0.0 +EX_fru_e;b3236;;fru_e --> ;0.0;0.0 +EX_fum_e;b3236;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3236;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3236;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3236;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3236;;h_e <=> ;17.530865429786523;16.565934969375554 +EX_h2o_e;b3236;;h2o_e <=> ;29.175827135565836;30.872445219424566 +EX_lac__D_e;b3236;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3236;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3236;;nh4_e <=> ;-4.765319193197444;-4.503027427767261 +EX_o2_e;b3236;;o2_e <=> ;-21.799492655998886;-23.902117497140686 +EX_pi_e;b3236;;pi_e <=> ;-3.214895047684769;-3.0379414243191736 +EX_pyr_e;b3236;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3236;;succ_e --> ;0.0;0.0 +FBA;b3236;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.178557551643177 +FBP;b3236;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3236;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3236;;for_c --> for_e;0.0;0.0 +FRD7;b3236;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3236;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3236;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;7.448785511861678 +FUMt2_2;b3236;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3236;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b3236;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;17.804724579806027 +GLCpts;b3236;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3236;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21116199260565008 +GLNabc;b3236;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3236;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.291865435161611 +GLUN;b3236;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3236;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3236;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3236;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b3236;;h2o_e <=> h2o_c;-29.175827135565836;-30.872445219424566 +ICDHyr;b3236;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;8.33976194448677 +ICL;b3236;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3236;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3236;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3236;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3236;;mal__L_c + nad_c --> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b3236;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.7379908852183181 +ME2;b3236;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;6.710794626643363 +NADH16;b3236;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.355449482419694 +NADTRHD;b3236;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3236;;nh4_e <=> nh4_c;4.765319193197444;4.503027427767261 +O2t;b3236;;o2_e <=> o2_c;21.799492655998886;23.902117497140686 +PDH;b3236;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.43476748178616 +PFK;b3236;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.178557551643177 +PFL;b3236;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3236;;g6p_c <=> f6p_c;4.860861146496871;9.83070704542762 +PGK;b3236;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-17.80472457980603 +PGL;b3236;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b3236;;2pg_c <=> 3pg_c;-14.716139568742859;-16.569298921072935 +PIt2r;b3236;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.0379414243191736 +PPC;b3236;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;9.8152532709964 +PPCK;b3236;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3236;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.6746371436723706 +PTAr;b3236;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3236;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b3236;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3236;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.5935989060811157 +RPI;b3236;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.5935989060811155 +SUCCt2_2;b3236;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3236;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3236;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;7.44878551186168 +SUCOAS;b3236;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-7.4487855118616775 +TALA;b3236;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.14773907108780132 +THD2;b3236;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3236;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.1477390710878013 +TKT2;b3236;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.44585983499331433 +TPI;b3236;;dhap_c <=> g3p_c;7.477381962160304;9.178557551643177 +ACALD;b1479;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1479;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1479;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1479;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.0072495753503325 +ACONTb;b1479;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325 +ACt2r;b1479;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1479;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1479;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096 +AKGt2r;b1479;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1479;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1479;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1479;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1479;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306 +CO2t;b1479;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204976 +CS;b1479;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350332 +CYTBD;b1479;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.598985311997545 +D_LACt2;b1479;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1479;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283 +ETOHt2r;b1479;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1479;;ac_e --> ;0.0;0.0 +EX_acald_e;b1479;;acald_e --> ;0.0;0.0 +EX_akg_e;b1479;;akg_e --> ;0.0;0.0 +EX_co2_e;b1479;;co2_e <=> ;22.809833310205086;22.809833310204976 +EX_etoh_e;b1479;;etoh_e --> ;0.0;0.0 +EX_for_e;b1479;;for_e --> ;0.0;0.0 +EX_fru_e;b1479;;fru_e --> ;0.0;0.0 +EX_fum_e;b1479;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1479;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1479;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1479;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1479;;h_e <=> ;17.530865429786523;17.530865429786726 +EX_h2o_e;b1479;;h2o_e <=> ;29.175827135565836;29.175827135565825 +EX_lac__D_e;b1479;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1479;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1479;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1479;;o2_e <=> ;-21.799492655998886;-21.79949265599877 +EX_pi_e;b1479;;pi_e <=> ;-3.214895047684769;-3.214895047684781 +EX_pyr_e;b1479;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1479;;succ_e --> ;0.0;0.0 +FBA;b1479;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160283 +FBP;b1479;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1479;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1479;;for_c --> for_e;0.0;0.0 +FRD7;b1479;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1479;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1479;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097 +FUMt2_2;b1479;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1479;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.95998494457466 +GAPD;b1479;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604 +GLCpts;b1479;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1479;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182767 +GLNabc;b1479;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1479;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1479;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1479;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1479;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1479;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574659 +H2Ot;b1479;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825 +ICDHyr;b1479;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350333 +ICL;b1479;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1479;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1479;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1479;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1479;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.0643756614820985 +ME1;b1479;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1479;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1479;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051544 +NADTRHD;b1479;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1479;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1479;;o2_e <=> o2_c;21.799492655998886;21.79949265599877 +PDH;b1479;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166617 +PFK;b1479;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160284 +PFL;b1479;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1479;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496814 +PGK;b1479;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608 +PGL;b1479;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574659 +PGM;b1479;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283 +PIt2r;b1479;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684781 +PPC;b1479;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687285 +PPCK;b1479;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1479;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1479;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1479;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067852 +PYRt2;b1479;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1479;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075303 +RPI;b1479;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067129 +SUCCt2_2;b1479;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1479;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1479;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097 +SUCOAS;b1479;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097 +TALA;b1479;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615672 +THD2;b1479;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1479;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261567 +TKT2;b1479;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245964 +TPI;b1479;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160283 +ACALD;b2463;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2463;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2463;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2463;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2463;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2463;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2463;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2463;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2463;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2463;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2463;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2463;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2463;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2463;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2463;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2463;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2463;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2463;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2463;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2463;;ac_e --> ;0.0;0.0 +EX_acald_e;b2463;;acald_e --> ;0.0;0.0 +EX_akg_e;b2463;;akg_e --> ;0.0;0.0 +EX_co2_e;b2463;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2463;;etoh_e --> ;0.0;0.0 +EX_for_e;b2463;;for_e --> ;0.0;0.0 +EX_fru_e;b2463;;fru_e --> ;0.0;0.0 +EX_fum_e;b2463;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2463;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2463;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2463;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2463;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2463;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2463;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2463;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2463;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2463;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2463;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2463;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2463;;succ_e --> ;0.0;0.0 +FBA;b2463;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2463;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2463;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2463;;for_c --> for_e;0.0;0.0 +FRD7;b2463;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2463;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2463;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2463;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2463;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2463;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2463;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2463;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2463;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2463;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2463;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2463;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2463;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2463;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2463;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2463;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2463;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2463;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2463;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2463;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2463;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2463;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2463;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2463;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2463;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2463;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2463;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2463;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2463;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2463;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2463;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2463;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2463;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2463;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2463;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2463;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2463;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2463;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2463;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2463;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2463;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2463;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2463;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2463;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2463;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2463;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2463;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2463;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2463;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2463;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2463;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2463;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2286;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.279455380486583 +ACALDt;b2286;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2286;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961317 +ACONTa;b2286;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646943348 +ACONTb;b2286;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694335 +ACt2r;b2286;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961317 +ADK1;b2286;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2286;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2286;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2286;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.279455380486583 +ATPM;b2286;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2286;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810925 +Biomass_Ecoli_core;b2286;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973530966 +CO2t;b2286;;co2_e <=> co2_c;-22.809833310205086;0.37817819229208954 +CS;b2286;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646943345 +CYTBD;b2286;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;-3.545079361619323e-15 +D_LACt2;b2286;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2286;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.120688607914612 +ETOHt2r;b2286;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.279455380486583 +EX_ac_e;b2286;;ac_e --> ;0.0;8.503585277961317 +EX_acald_e;b2286;;acald_e --> ;0.0;0.0 +EX_akg_e;b2286;;akg_e --> ;0.0;0.0 +EX_co2_e;b2286;;co2_e <=> ;22.809833310205086;-0.37817819229208954 +EX_etoh_e;b2286;;etoh_e --> ;0.0;8.279455380486583 +EX_for_e;b2286;;for_e --> ;0.0;17.80467421793533 +EX_fru_e;b2286;;fru_e --> ;0.0;0.0 +EX_fum_e;b2286;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2286;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2286;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2286;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2286;;h_e <=> ;17.530865429786523;30.55421826758705 +EX_h2o_e;b2286;;h2o_e <=> ;29.175827135565836;-7.115795981726764 +EX_lac__D_e;b2286;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2286;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2286;;nh4_e <=> ;-4.765319193197444;-1.1541557323166962 +EX_o2_e;b2286;;o2_e <=> ;-21.799492655998886;4.335920479686503e-15 +EX_pi_e;b2286;;pi_e <=> ;-3.214895047684769;-0.7786444931913017 +EX_pyr_e;b2286;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2286;;succ_e --> ;0.0;0.0 +FBA;b2286;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898297 +FBP;b2286;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2286;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2286;;for_c --> for_e;0.0;17.80467421793533 +FRD7;b2286;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2286;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2286;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-5.4142647879431474e-15 +FUMt2_2;b2286;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2286;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2286;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718637 +GLCpts;b2286;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2286;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318666 +GLNabc;b2286;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2286;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.1000335160693777 +GLUN;b2286;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2286;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2286;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2286;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2286;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726809 +ICDHyr;b2286;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646943348 +ICL;b2286;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2286;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2286;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2286;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2286;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-4.961305216395132e-16 +ME1;b2286;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2286;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2286;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2286;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2286;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323166962 +O2t;b2286;;o2_e <=> o2_c;21.799492655998886;-1.7817144499861175e-15 +PDH;b2286;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2286;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898297 +PFL;b2286;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935325 +PGI;b2286;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2286;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.437336380718637 +PGL;b2286;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2286;;2pg_c <=> 3pg_c;-14.716139568742859;-19.120688607914612 +PIt2r;b2286;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931913017 +PPC;b2286;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615037 +PPCK;b2286;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2286;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2286;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961317 +PYK;b2286;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945505 +PYRt2;b2286;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2286;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.15214332826974167 +RPI;b2286;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974164 +SUCCt2_2;b2286;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2286;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2286;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;-3.545079361619323e-15 +SUCOAS;b2286;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;4.550053240415208e-15 +TALA;b2286;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.037866501707647236 +THD2;b2286;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.629194102456621 +TKT1;b2286;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764723 +TKT2;b2286;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209441 +TPI;b2286;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898297 +ACALD;b2279;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2279;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2279;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2279;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2279;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2279;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2279;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2279;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2279;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2279;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2279;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2279;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2279;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2279;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2279;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2279;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2279;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2279;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2279;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2279;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2279;;acald_e --> ;0.0;0.0 +EX_akg_e;b2279;;akg_e --> ;0.0;0.0 +EX_co2_e;b2279;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2279;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2279;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2279;;fru_e --> ;0.0;0.0 +EX_fum_e;b2279;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2279;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2279;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2279;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2279;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2279;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2279;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2279;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2279;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2279;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2279;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2279;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2279;;succ_e --> ;0.0;0.0 +FBA;b2279;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2279;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2279;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2279;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2279;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2279;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2279;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2279;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2279;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2279;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2279;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2279;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2279;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2279;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2279;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2279;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2279;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2279;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2279;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2279;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2279;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2279;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2279;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2279;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2279;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2279;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2279;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2279;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2279;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2279;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2279;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2279;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2279;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2279;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2279;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2279;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2279;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2279;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2279;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2279;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2279;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2279;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2279;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2279;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2279;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2279;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2279;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2279;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2279;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2279;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2279;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2279;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2279;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2279;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2279;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2279;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2276;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2276;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2276;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2276;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2276;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2276;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2276;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2276;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2276;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2276;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2276;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2276;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2276;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2276;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2276;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2276;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2276;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2276;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2276;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2276;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2276;;acald_e --> ;0.0;0.0 +EX_akg_e;b2276;;akg_e --> ;0.0;0.0 +EX_co2_e;b2276;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2276;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2276;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2276;;fru_e --> ;0.0;0.0 +EX_fum_e;b2276;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2276;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2276;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2276;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2276;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2276;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2276;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2276;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2276;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2276;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2276;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2276;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2276;;succ_e --> ;0.0;0.0 +FBA;b2276;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2276;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2276;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2276;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2276;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2276;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2276;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2276;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2276;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2276;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2276;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2276;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2276;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2276;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2276;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2276;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2276;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2276;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2276;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2276;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2276;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2276;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2276;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2276;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2276;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2276;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2276;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2276;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2276;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2276;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2276;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2276;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2276;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2276;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2276;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2276;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2276;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2276;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2276;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2276;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2276;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2276;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2276;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2276;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2276;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2276;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2276;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2276;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2276;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2276;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2276;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2276;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2276;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2276;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2276;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2276;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2280;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2280;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2280;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2280;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2280;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2280;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2280;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2280;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2280;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2280;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2280;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2280;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2280;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2280;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2280;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2280;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2280;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2280;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2280;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2280;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2280;;acald_e --> ;0.0;0.0 +EX_akg_e;b2280;;akg_e --> ;0.0;0.0 +EX_co2_e;b2280;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2280;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2280;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2280;;fru_e --> ;0.0;0.0 +EX_fum_e;b2280;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2280;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2280;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2280;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2280;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2280;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2280;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2280;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2280;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2280;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2280;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2280;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2280;;succ_e --> ;0.0;0.0 +FBA;b2280;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2280;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2280;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2280;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2280;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2280;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2280;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2280;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2280;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2280;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2280;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2280;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2280;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2280;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2280;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2280;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2280;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2280;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2280;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2280;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2280;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2280;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2280;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2280;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2280;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2280;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2280;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2280;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2280;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2280;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2280;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2280;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2280;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2280;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2280;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2280;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2280;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2280;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2280;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2280;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2280;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2280;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2280;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2280;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2280;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2280;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2280;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2280;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2280;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2280;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2280;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2280;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2280;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2280;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2280;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2280;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2288;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2288;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2288;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2288;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2288;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2288;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2288;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2288;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2288;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2288;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2288;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2288;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2288;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2288;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2288;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2288;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2288;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2288;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2288;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2288;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2288;;acald_e --> ;0.0;0.0 +EX_akg_e;b2288;;akg_e --> ;0.0;0.0 +EX_co2_e;b2288;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2288;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2288;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2288;;fru_e --> ;0.0;0.0 +EX_fum_e;b2288;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2288;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2288;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2288;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2288;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2288;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2288;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2288;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2288;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2288;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2288;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2288;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2288;;succ_e --> ;0.0;0.0 +FBA;b2288;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2288;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2288;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2288;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2288;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2288;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2288;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2288;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2288;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2288;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2288;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2288;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2288;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2288;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2288;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2288;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2288;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2288;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2288;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2288;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2288;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2288;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2288;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2288;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2288;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2288;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2288;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2288;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2288;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2288;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2288;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2288;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2288;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2288;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2288;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2288;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2288;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2288;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2288;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2288;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2288;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2288;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2288;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2288;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2288;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2288;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2288;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2288;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2288;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2288;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2288;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2288;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2288;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2288;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2288;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2288;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2284;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2284;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2284;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2284;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2284;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2284;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2284;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2284;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2284;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2284;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2284;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2284;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2284;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2284;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2284;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2284;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2284;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2284;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2284;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2284;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2284;;acald_e --> ;0.0;0.0 +EX_akg_e;b2284;;akg_e --> ;0.0;0.0 +EX_co2_e;b2284;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2284;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2284;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2284;;fru_e --> ;0.0;0.0 +EX_fum_e;b2284;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2284;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2284;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2284;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2284;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2284;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2284;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2284;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2284;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2284;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2284;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2284;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2284;;succ_e --> ;0.0;0.0 +FBA;b2284;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2284;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2284;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2284;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2284;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2284;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2284;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2284;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2284;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2284;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2284;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2284;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2284;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2284;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2284;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2284;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2284;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2284;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2284;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2284;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2284;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2284;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2284;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2284;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2284;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2284;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2284;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2284;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2284;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2284;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2284;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2284;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2284;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2284;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2284;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2284;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2284;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2284;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2284;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2284;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2284;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2284;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2284;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2284;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2284;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2284;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2284;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2284;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2284;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2284;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2284;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2284;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2284;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2284;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2284;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2284;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2287;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2287;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2287;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2287;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2287;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2287;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2287;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2287;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2287;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2287;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2287;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2287;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2287;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2287;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2287;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2287;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2287;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2287;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2287;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2287;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2287;;acald_e --> ;0.0;0.0 +EX_akg_e;b2287;;akg_e --> ;0.0;0.0 +EX_co2_e;b2287;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2287;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2287;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2287;;fru_e --> ;0.0;0.0 +EX_fum_e;b2287;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2287;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2287;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2287;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2287;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2287;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2287;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2287;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2287;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2287;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2287;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2287;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2287;;succ_e --> ;0.0;0.0 +FBA;b2287;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2287;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2287;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2287;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2287;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2287;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2287;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2287;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2287;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2287;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2287;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2287;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2287;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2287;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2287;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2287;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2287;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2287;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2287;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2287;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2287;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2287;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2287;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2287;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2287;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2287;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2287;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2287;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2287;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2287;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2287;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2287;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2287;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2287;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2287;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2287;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2287;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2287;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2287;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2287;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2287;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2287;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2287;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2287;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2287;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2287;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2287;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2287;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2287;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2287;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2287;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2287;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2287;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2287;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2287;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2287;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2281;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2281;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2281;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2281;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2281;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2281;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2281;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2281;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2281;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2281;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2281;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2281;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2281;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2281;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2281;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2281;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2281;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2281;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2281;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2281;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2281;;acald_e --> ;0.0;0.0 +EX_akg_e;b2281;;akg_e --> ;0.0;0.0 +EX_co2_e;b2281;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2281;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2281;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2281;;fru_e --> ;0.0;0.0 +EX_fum_e;b2281;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2281;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2281;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2281;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2281;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2281;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2281;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2281;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2281;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2281;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2281;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2281;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2281;;succ_e --> ;0.0;0.0 +FBA;b2281;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2281;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2281;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2281;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2281;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2281;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2281;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2281;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2281;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2281;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2281;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2281;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2281;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2281;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2281;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2281;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2281;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2281;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2281;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2281;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2281;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2281;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2281;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2281;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2281;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2281;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2281;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2281;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2281;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2281;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2281;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2281;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2281;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2281;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2281;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2281;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2281;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2281;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2281;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2281;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2281;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2281;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2281;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2281;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2281;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2281;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2281;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2281;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2281;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2281;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2281;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2281;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2281;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2281;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2281;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2281;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2277;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2277;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2277;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2277;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2277;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2277;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2277;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2277;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2277;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2277;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2277;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2277;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2277;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2277;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2277;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2277;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2277;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2277;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2277;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2277;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2277;;acald_e --> ;0.0;0.0 +EX_akg_e;b2277;;akg_e --> ;0.0;0.0 +EX_co2_e;b2277;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2277;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2277;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2277;;fru_e --> ;0.0;0.0 +EX_fum_e;b2277;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2277;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2277;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2277;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2277;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2277;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2277;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2277;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2277;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2277;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2277;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2277;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2277;;succ_e --> ;0.0;0.0 +FBA;b2277;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2277;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2277;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2277;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2277;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2277;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2277;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2277;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2277;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2277;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2277;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2277;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2277;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2277;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2277;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2277;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2277;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2277;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2277;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2277;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2277;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2277;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2277;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2277;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2277;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2277;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2277;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2277;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2277;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2277;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2277;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2277;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2277;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2277;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2277;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2277;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2277;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2277;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2277;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2277;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2277;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2277;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2277;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2277;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2277;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2277;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2277;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2277;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2277;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2277;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2277;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2277;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2277;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2277;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2277;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2277;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2285;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2285;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2285;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2285;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2285;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2285;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2285;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2285;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2285;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2285;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2285;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2285;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2285;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2285;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2285;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2285;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2285;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2285;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2285;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2285;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2285;;acald_e --> ;0.0;0.0 +EX_akg_e;b2285;;akg_e --> ;0.0;0.0 +EX_co2_e;b2285;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2285;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2285;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2285;;fru_e --> ;0.0;0.0 +EX_fum_e;b2285;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2285;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2285;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2285;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2285;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2285;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2285;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2285;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2285;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2285;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2285;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2285;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2285;;succ_e --> ;0.0;0.0 +FBA;b2285;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2285;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2285;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2285;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2285;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2285;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2285;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2285;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2285;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2285;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2285;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2285;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2285;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2285;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2285;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2285;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2285;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2285;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2285;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2285;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2285;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2285;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2285;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2285;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2285;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2285;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2285;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2285;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2285;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2285;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2285;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2285;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2285;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2285;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2285;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2285;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2285;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2285;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2285;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2285;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2285;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2285;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2285;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2285;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2285;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2285;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2285;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2285;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2285;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2285;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2285;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2285;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2285;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2285;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2285;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2285;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2282;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2282;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2282;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2282;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2282;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2282;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2282;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2282;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2282;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2282;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2282;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2282;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2282;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2282;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2282;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2282;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2282;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2282;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2282;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2282;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2282;;acald_e --> ;0.0;0.0 +EX_akg_e;b2282;;akg_e --> ;0.0;0.0 +EX_co2_e;b2282;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2282;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2282;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2282;;fru_e --> ;0.0;0.0 +EX_fum_e;b2282;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2282;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2282;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2282;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2282;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2282;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2282;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2282;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2282;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2282;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2282;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2282;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2282;;succ_e --> ;0.0;0.0 +FBA;b2282;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2282;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2282;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2282;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2282;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2282;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2282;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2282;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2282;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2282;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2282;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2282;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2282;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2282;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2282;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2282;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2282;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2282;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2282;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2282;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2282;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2282;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2282;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2282;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2282;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2282;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2282;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2282;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2282;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2282;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2282;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2282;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2282;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2282;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2282;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2282;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2282;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2282;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2282;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2282;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2282;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2282;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2282;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2282;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2282;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2282;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2282;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2282;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2282;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2282;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2282;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2282;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2282;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2282;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2282;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2282;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2278;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2278;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2278;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2278;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2278;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2278;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2278;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2278;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2278;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2278;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2278;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2278;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2278;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2278;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2278;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2278;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2278;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2278;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2278;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2278;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2278;;acald_e --> ;0.0;0.0 +EX_akg_e;b2278;;akg_e --> ;0.0;0.0 +EX_co2_e;b2278;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2278;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2278;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2278;;fru_e --> ;0.0;0.0 +EX_fum_e;b2278;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2278;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2278;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2278;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2278;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2278;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2278;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2278;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2278;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2278;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2278;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2278;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2278;;succ_e --> ;0.0;0.0 +FBA;b2278;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2278;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2278;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2278;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2278;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2278;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2278;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2278;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2278;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2278;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2278;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2278;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2278;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2278;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2278;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2278;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2278;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2278;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2278;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2278;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2278;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2278;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2278;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2278;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2278;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2278;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2278;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2278;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2278;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2278;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2278;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2278;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2278;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2278;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2278;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2278;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2278;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2278;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2278;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2278;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2278;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2278;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2278;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2278;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2278;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2278;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2278;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2278;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2278;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2278;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2278;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2278;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2278;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2278;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2278;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2278;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b2283;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658 +ACALDt;b2283;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2283;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305 +ACONTa;b2283;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648 +ACONTb;b2283;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265 +ACt2r;b2283;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305 +ADK1;b2283;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2283;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2283;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2283;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658 +ATPM;b2283;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2283;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906 +Biomass_Ecoli_core;b2283;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088 +CO2t;b2283;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944 +CS;b2283;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645 +CYTBD;b2283;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0 +D_LACt2;b2283;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2283;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146 +ETOHt2r;b2283;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658 +EX_ac_e;b2283;;ac_e --> ;0.0;8.503585277961305 +EX_acald_e;b2283;;acald_e --> ;0.0;0.0 +EX_akg_e;b2283;;akg_e --> ;0.0;0.0 +EX_co2_e;b2283;;co2_e <=> ;22.809833310205086;-0.37817819229207944 +EX_etoh_e;b2283;;etoh_e --> ;0.0;8.27945538048658 +EX_for_e;b2283;;for_e --> ;0.0;17.804674217935307 +EX_fru_e;b2283;;fru_e --> ;0.0;0.0 +EX_fum_e;b2283;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2283;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2283;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2283;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2283;;h_e <=> ;17.530865429786523;30.55421826758701 +EX_h2o_e;b2283;;h2o_e <=> ;29.175827135565836;-7.115795981726792 +EX_lac__D_e;b2283;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2283;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2283;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029 +EX_o2_e;b2283;;o2_e <=> ;-21.799492655998886;0.0 +EX_pi_e;b2283;;pi_e <=> ;-3.214895047684769;-0.7786444931912647 +EX_pyr_e;b2283;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2283;;succ_e --> ;0.0;0.0 +FBA;b2283;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288 +FBP;b2283;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2283;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2283;;for_c --> for_e;0.0;17.804674217935307 +FRD7;b2283;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2283;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2283;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b2283;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2283;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0 +GAPD;b2283;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627 +GLCpts;b2283;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2283;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986 +GLNabc;b2283;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2283;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384 +GLUN;b2283;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2283;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2283;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2283;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0 +H2Ot;b2283;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792 +ICDHyr;b2283;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648 +ICL;b2283;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2283;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2283;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2283;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2283;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b2283;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2283;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2283;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0 +NADTRHD;b2283;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2283;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029 +O2t;b2283;;o2_e <=> o2_c;21.799492655998886;0.0 +PDH;b2283;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2283;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288 +PFL;b2283;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307 +PGI;b2283;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263 +PGK;b2283;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863 +PGL;b2283;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b2283;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146 +PIt2r;b2283;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647 +PPC;b2283;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059 +PPCK;b2283;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2283;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2283;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305 +PYK;b2283;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494 +PYRt2;b2283;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2283;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415 +RPI;b2283;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147 +SUCCt2_2;b2283;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2283;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2283;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b2283;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b2283;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712 +THD2;b2283;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143 +TKT1;b2283;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712 +TKT2;b2283;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436 +TPI;b2283;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288 +ACALD;b3962;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3962;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3962;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;8.660501956727496e-15 +ACONTa;b3962;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.0072495753503325 +ACONTb;b3962;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325 +ACt2r;b3962;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3962;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3962;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096 +AKGt2r;b3962;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3962;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3962;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3962;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451744 +Biomass_Ecoli_core;b3962;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3962;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204965 +CS;b3962;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.0072495753503325 +CYTBD;b3962;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199752 +D_LACt2;b3962;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3962;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283 +ETOHt2r;b3962;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3962;;ac_e --> ;0.0;0.0 +EX_acald_e;b3962;;acald_e --> ;0.0;0.0 +EX_akg_e;b3962;;akg_e --> ;0.0;0.0 +EX_co2_e;b3962;;co2_e <=> ;22.809833310205086;22.809833310204965 +EX_etoh_e;b3962;;etoh_e --> ;0.0;0.0 +EX_for_e;b3962;;for_e --> ;0.0;0.0 +EX_fru_e;b3962;;fru_e --> ;0.0;0.0 +EX_fum_e;b3962;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3962;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3962;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3962;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3962;;h_e <=> ;17.530865429786523;17.530865429786747 +EX_h2o_e;b3962;;h2o_e <=> ;29.175827135565836;29.17582713556577 +EX_lac__D_e;b3962;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3962;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3962;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3962;;o2_e <=> ;-21.799492655998886;-21.799492655998755 +EX_pi_e;b3962;;pi_e <=> ;-3.214895047684769;-3.2148950476847435 +EX_pyr_e;b3962;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3962;;succ_e --> ;0.0;0.0 +FBA;b3962;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.4773819621602815 +FBP;b3962;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3962;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3962;;for_c --> for_e;0.0;0.0 +FRD7;b3962;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3962;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3962;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097 +FUMt2_2;b3962;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3962;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574662 +GAPD;b3962;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604 +GLCpts;b3962;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3962;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3962;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3962;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3962;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3962;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3962;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3962;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574661 +H2Ot;b3962;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556577 +ICDHyr;b3962;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350333 +ICL;b3962;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3962;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3962;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3962;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3962;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482096 +ME1;b3962;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3962;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3962;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515414 +NADTRHD;b3962;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3962;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3962;;o2_e <=> o2_c;21.799492655998886;21.799492655998755 +PDH;b3962;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166615 +PFK;b3962;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160282 +PFL;b3962;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3962;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496811 +PGK;b3962;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608 +PGL;b3962;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.9599849445746615 +PGM;b3962;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283 +PIt2r;b3962;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847435 +PPC;b3962;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687303 +PPCK;b3962;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3962;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3962;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;-8.660501956727496e-15 +PYK;b3962;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067872 +PYRt2;b3962;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3962;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507533 +RPI;b3962;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067128 +SUCCt2_2;b3962;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3962;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3962;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097 +SUCOAS;b3962;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097 +TALA;b3962;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.496983757261568 +THD2;b3962;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3962;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261568 +TKT2;b3962;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459642 +TPI;b3962;;dhap_c <=> g3p_c;7.477381962160304;7.4773819621602815 +ACALD;b1602;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1602;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1602;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1602;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1602;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1602;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1602;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1602;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1602;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1602;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1602;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1602;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1602;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1602;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1602;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1602;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1602;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1602;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1602;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1602;;ac_e --> ;0.0;0.0 +EX_acald_e;b1602;;acald_e --> ;0.0;0.0 +EX_akg_e;b1602;;akg_e --> ;0.0;0.0 +EX_co2_e;b1602;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1602;;etoh_e --> ;0.0;0.0 +EX_for_e;b1602;;for_e --> ;0.0;0.0 +EX_fru_e;b1602;;fru_e --> ;0.0;0.0 +EX_fum_e;b1602;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1602;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1602;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1602;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1602;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1602;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1602;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1602;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1602;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1602;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1602;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1602;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1602;;succ_e --> ;0.0;0.0 +FBA;b1602;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1602;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1602;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1602;;for_c --> for_e;0.0;0.0 +FRD7;b1602;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1602;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1602;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1602;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1602;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1602;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1602;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1602;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1602;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1602;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1602;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1602;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1602;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1602;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1602;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1602;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1602;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1602;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1602;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1602;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1602;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1602;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1602;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1602;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1602;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1602;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1602;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1602;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1602;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1602;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1602;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1602;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1602;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1602;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1602;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1602;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1602;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1602;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1602;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1602;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1602;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1602;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1602;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1602;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1602;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1602;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1602;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1602;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1602;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1602;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1602;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1602;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1603;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1603;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1603;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1603;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1603;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1603;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1603;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1603;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1603;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1603;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1603;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1603;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1603;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1603;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1603;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1603;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1603;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1603;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1603;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1603;;ac_e --> ;0.0;0.0 +EX_acald_e;b1603;;acald_e --> ;0.0;0.0 +EX_akg_e;b1603;;akg_e --> ;0.0;0.0 +EX_co2_e;b1603;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1603;;etoh_e --> ;0.0;0.0 +EX_for_e;b1603;;for_e --> ;0.0;0.0 +EX_fru_e;b1603;;fru_e --> ;0.0;0.0 +EX_fum_e;b1603;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1603;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1603;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1603;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1603;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1603;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1603;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1603;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1603;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1603;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1603;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1603;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1603;;succ_e --> ;0.0;0.0 +FBA;b1603;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1603;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1603;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1603;;for_c --> for_e;0.0;0.0 +FRD7;b1603;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1603;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1603;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1603;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1603;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1603;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1603;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1603;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1603;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1603;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1603;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1603;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1603;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1603;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1603;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1603;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1603;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1603;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1603;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1603;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1603;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1603;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1603;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1603;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1603;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1603;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1603;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1603;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1603;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1603;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1603;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1603;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1603;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1603;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1603;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1603;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1603;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1603;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1603;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1603;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1603;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1603;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1603;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1603;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1603;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1603;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1603;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1603;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1603;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1603;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1603;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1603;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0451;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0451;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0451;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0451;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0451;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0451;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0451;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0451;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0451;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0451;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0451;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0451;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0451;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0451;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0451;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0451;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0451;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0451;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0451;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0451;;ac_e --> ;0.0;0.0 +EX_acald_e;b0451;;acald_e --> ;0.0;0.0 +EX_akg_e;b0451;;akg_e --> ;0.0;0.0 +EX_co2_e;b0451;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0451;;etoh_e --> ;0.0;0.0 +EX_for_e;b0451;;for_e --> ;0.0;0.0 +EX_fru_e;b0451;;fru_e --> ;0.0;0.0 +EX_fum_e;b0451;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0451;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0451;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0451;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0451;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0451;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0451;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0451;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0451;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0451;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0451;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0451;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0451;;succ_e --> ;0.0;0.0 +FBA;b0451;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0451;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0451;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0451;;for_c --> for_e;0.0;0.0 +FRD7;b0451;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0451;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0451;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0451;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0451;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0451;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0451;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0451;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0451;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0451;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0451;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0451;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0451;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0451;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0451;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0451;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0451;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0451;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0451;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0451;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0451;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0451;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0451;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0451;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0451;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0451;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0451;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0451;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0451;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0451;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0451;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0451;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0451;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0451;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0451;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0451;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0451;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0451;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0451;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0451;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0451;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0451;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0451;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0451;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0451;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0451;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0451;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0451;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0451;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0451;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0451;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0451;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0114;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0114;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0114;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0114;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;4.757262793109044 +ACONTb;b0114;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;4.757262793109045 +ACt2r;b0114;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0114;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0114;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;3.897707559161589 +AKGt2r;b0114;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0114;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0114;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0114;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;43.67177423054358 +Biomass_Ecoli_core;b0114;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.7966959254309572 +CO2t;b0114;;co2_e <=> co2_c;-22.809833310205086;-18.353086762883773 +CS;b0114;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;4.757262793109044 +CYTBD;b0114;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;42.60717298942525 +D_LACt2;b0114;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0114;;2pg_c <=> h2o_c + pep_c;14.716139568742859;12.696576698806151 +ETOHt2r;b0114;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0114;;ac_e --> ;0.0;0.0 +EX_acald_e;b0114;;acald_e --> ;0.0;0.0 +EX_akg_e;b0114;;akg_e --> ;0.0;0.0 +EX_co2_e;b0114;;co2_e <=> ;22.809833310205086;18.353086762883773 +EX_etoh_e;b0114;;etoh_e --> ;0.0;0.0 +EX_for_e;b0114;;for_e --> ;0.0;7.743119782439185 +EX_fru_e;b0114;;fru_e --> ;0.0;0.0 +EX_fum_e;b0114;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0114;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0114;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0114;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0114;;h_e <=> ;17.530865429786523;23.72484004658422 +EX_h2o_e;b0114;;h2o_e <=> ;29.175827135565836;24.156538562093008 +EX_lac__D_e;b0114;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0114;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0114;;nh4_e <=> ;-4.765319193197444;-4.344223542189922 +EX_o2_e;b0114;;o2_e <=> ;-21.799492655998886;-21.303586494712622 +EX_pi_e;b0114;;pi_e <=> ;-3.214895047684769;-2.930805300882891 +EX_pyr_e;b0114;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0114;;succ_e --> ;0.0;0.0 +FBA;b0114;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;5.213817144797803 +FBP;b0114;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0114;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0114;;for_c --> for_e;0.0;7.743119782439185 +FRD7;b0114;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0114;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0114;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;3.8977075591615895 +FUMt2_2;b0114;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0114;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;11.98112825452808 +GAPD;b0114;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;13.888433803250864 +GLCpts;b0114;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0114;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2037151481326957 +GLNabc;b0114;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0114;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.140508394057227 +GLUN;b0114;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0114;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0114;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0114;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;11.981128254528079 +H2Ot;b0114;;h2o_e <=> h2o_c;-29.175827135565836;-24.156538562093008 +ICDHyr;b0114;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;4.757262793109044 +ICL;b0114;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0114;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0114;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0114;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0114;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;3.8977075591615895 +ME1;b0114;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0114;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0114;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.709465430263656 +NADTRHD;b0114;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;14.199736061186005 +NH4t;b0114;;nh4_e <=> nh4_c;4.765319193197444;4.344223542189923 +O2t;b0114;;o2_e <=> o2_c;21.799492655998886;21.303586494712622 +PDH;b0114;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b0114;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;5.213817144797803 +PFL;b0114;;coa_c + pyr_c --> accoa_c + for_c;0.0;7.743119782439184 +PGI;b0114;;g6p_c <=> f6p_c;4.860861146496871;-2.144450919241426 +PGK;b0114;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-13.888433803250866 +PGL;b0114;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;11.98112825452808 +PGM;b0114;;2pg_c <=> 3pg_c;-14.716139568742859;-12.696576698806151 +PIt2r;b0114;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.930805300882891 +PPC;b0114;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.2830118439149403 +PPCK;b0114;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0114;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0114;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0114;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b0114;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0114;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;7.414753805152278 +RPI;b0114;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-4.566374449375802 +SUCCt2_2;b0114;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0114;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0114;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;3.8977075591615895 +SUCOAS;b0114;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-3.8977075591615895 +TALA;b0114;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;3.8511805171164277 +THD2;b0114;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0114;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;3.851180517116427 +TKT2;b0114;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;3.563573288035852 +TPI;b0114;;dhap_c <=> g3p_c;7.477381962160304;5.213817144797803 +ACALD;b0115;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0115;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0115;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0115;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;4.7572627931090485 +ACONTb;b0115;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;4.7572627931090485 +ACt2r;b0115;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0115;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0115;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;3.8977075591615886 +AKGt2r;b0115;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0115;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0115;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0115;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;43.67177423054356 +Biomass_Ecoli_core;b0115;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.7966959254309566 +CO2t;b0115;;co2_e <=> co2_c;-22.809833310205086;-18.353086762883734 +CS;b0115;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;4.757262793109048 +CYTBD;b0115;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;42.60717298942521 +D_LACt2;b0115;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0115;;2pg_c <=> h2o_c + pep_c;14.716139568742859;12.69657669880616 +ETOHt2r;b0115;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0115;;ac_e --> ;0.0;0.0 +EX_acald_e;b0115;;acald_e --> ;0.0;0.0 +EX_akg_e;b0115;;akg_e --> ;0.0;0.0 +EX_co2_e;b0115;;co2_e <=> ;22.809833310205086;18.353086762883734 +EX_etoh_e;b0115;;etoh_e --> ;0.0;0.0 +EX_for_e;b0115;;for_e --> ;0.0;7.743119782439188 +EX_fru_e;b0115;;fru_e --> ;0.0;0.0 +EX_fum_e;b0115;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0115;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0115;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0115;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0115;;h_e <=> ;17.530865429786523;23.724840046584138 +EX_h2o_e;b0115;;h2o_e <=> ;29.175827135565836;24.156538562093008 +EX_lac__D_e;b0115;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0115;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0115;;nh4_e <=> ;-4.765319193197444;-4.344223542189918 +EX_o2_e;b0115;;o2_e <=> ;-21.799492655998886;-21.303586494712604 +EX_pi_e;b0115;;pi_e <=> ;-3.214895047684769;-2.930805300882857 +EX_pyr_e;b0115;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0115;;succ_e --> ;0.0;0.0 +FBA;b0115;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;5.2138171447978126 +FBP;b0115;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0115;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0115;;for_c --> for_e;0.0;7.743119782439188 +FRD7;b0115;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0115;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0115;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;3.8977075591615886 +FUMt2_2;b0115;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0115;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;11.981128254528052 +GAPD;b0115;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;13.888433803250873 +GLCpts;b0115;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0115;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20371514813269562 +GLNabc;b0115;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0115;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.140508394057224 +GLUN;b0115;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0115;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0115;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0115;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;11.981128254528048 +H2Ot;b0115;;h2o_e <=> h2o_c;-29.175827135565836;-24.156538562093008 +ICDHyr;b0115;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;4.7572627931090485 +ICL;b0115;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0115;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0115;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0115;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0115;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;3.8977075591615886 +ME1;b0115;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0115;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0115;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.70946543026361 +NADTRHD;b0115;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;14.199736061185966 +NH4t;b0115;;nh4_e <=> nh4_c;4.765319193197444;4.344223542189918 +O2t;b0115;;o2_e <=> o2_c;21.799492655998886;21.303586494712604 +PDH;b0115;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b0115;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;5.2138171447978126 +PFL;b0115;;coa_c + pyr_c --> accoa_c + for_c;0.0;7.743119782439187 +PGI;b0115;;g6p_c <=> f6p_c;4.860861146496871;-2.144450919241396 +PGK;b0115;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-13.888433803250875 +PGL;b0115;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;11.981128254528052 +PGM;b0115;;2pg_c <=> 3pg_c;-14.716139568742859;-12.69657669880616 +PIt2r;b0115;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.930805300882857 +PPC;b0115;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.283011843914949 +PPCK;b0115;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0115;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0115;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0115;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b0115;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0115;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;7.4147538051522615 +RPI;b0115;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-4.566374449375788 +SUCCt2_2;b0115;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0115;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0115;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;3.8977075591615886 +SUCOAS;b0115;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-3.8977075591615886 +TALA;b0115;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;3.8511805171164184 +THD2;b0115;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0115;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;3.8511805171164175 +TKT2;b0115;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;3.5635732880358435 +TPI;b0115;;dhap_c <=> g3p_c;7.477381962160304;5.2138171447978126 +ACALD;b3916;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3916;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3916;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3916;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350332 +ACONTb;b3916;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325 +ACt2r;b3916;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3916;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3916;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096 +AKGt2r;b3916;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3916;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3916;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3916;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454 +Biomass_Ecoli_core;b3916;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306 +CO2t;b3916;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204986 +CS;b3916;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350331 +CYTBD;b3916;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3916;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3916;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742825 +ETOHt2r;b3916;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3916;;ac_e --> ;0.0;0.0 +EX_acald_e;b3916;;acald_e --> ;0.0;0.0 +EX_akg_e;b3916;;akg_e --> ;0.0;0.0 +EX_co2_e;b3916;;co2_e <=> ;22.809833310205086;22.809833310204986 +EX_etoh_e;b3916;;etoh_e --> ;0.0;0.0 +EX_for_e;b3916;;for_e --> ;0.0;0.0 +EX_fru_e;b3916;;fru_e --> ;0.0;0.0 +EX_fum_e;b3916;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3916;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3916;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3916;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3916;;h_e <=> ;17.530865429786523;17.530865429786747 +EX_h2o_e;b3916;;h2o_e <=> ;29.175827135565836;29.17582713556578 +EX_lac__D_e;b3916;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3916;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3916;;nh4_e <=> ;-4.765319193197444;-4.765319193197458 +EX_o2_e;b3916;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3916;;pi_e <=> ;-3.214895047684769;-3.214895047684762 +EX_pyr_e;b3916;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3916;;succ_e --> ;0.0;0.0 +FBA;b3916;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.47738196216028 +FBP;b3916;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3916;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3916;;for_c --> for_e;0.0;0.0 +FRD7;b3916;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3916;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3916;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097 +FUMt2_2;b3916;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3916;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574671 +GAPD;b3916;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167597 +GLCpts;b3916;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3916;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2234617293318277 +GLNabc;b3916;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3916;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865631 +GLUN;b3916;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3916;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3916;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3916;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574671 +H2Ot;b3916;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556578 +ICDHyr;b3916;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350332 +ICL;b3916;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3916;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3916;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3916;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3916;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482097 +ME1;b3916;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3916;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3916;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051543 +NADTRHD;b3916;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3916;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3916;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3916;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166615 +PFK;b3916;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.47738196216028 +PFL;b3916;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3916;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496812 +PGK;b3916;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.0235261431676 +PGL;b3916;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574672 +PGM;b3916;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742825 +PIt2r;b3916;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684762 +PPC;b3916;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.50430947036873 +PPCK;b3916;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3916;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3916;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3916;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067857 +PYRt2;b3916;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3916;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507539 +RPI;b3916;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671326 +SUCCt2_2;b3916;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3916;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3916;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097 +SUCOAS;b3916;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097 +TALA;b3916;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615714 +THD2;b3916;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3916;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615714 +TKT2;b3916;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245968 +TPI;b3916;;dhap_c <=> g3p_c;7.477381962160304;7.47738196216028 +ACALD;b1723;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1723;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1723;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1723;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1723;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1723;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1723;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1723;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1723;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1723;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1723;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1723;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1723;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1723;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1723;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1723;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1723;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1723;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1723;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1723;;ac_e --> ;0.0;0.0 +EX_acald_e;b1723;;acald_e --> ;0.0;0.0 +EX_akg_e;b1723;;akg_e --> ;0.0;0.0 +EX_co2_e;b1723;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1723;;etoh_e --> ;0.0;0.0 +EX_for_e;b1723;;for_e --> ;0.0;0.0 +EX_fru_e;b1723;;fru_e --> ;0.0;0.0 +EX_fum_e;b1723;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1723;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1723;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1723;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1723;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1723;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1723;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1723;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1723;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1723;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1723;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1723;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1723;;succ_e --> ;0.0;0.0 +FBA;b1723;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1723;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1723;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1723;;for_c --> for_e;0.0;0.0 +FRD7;b1723;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1723;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1723;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1723;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1723;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1723;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1723;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1723;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1723;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1723;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1723;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1723;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1723;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1723;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1723;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1723;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1723;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1723;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1723;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1723;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1723;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1723;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1723;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1723;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1723;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1723;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1723;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1723;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1723;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1723;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1723;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1723;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1723;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1723;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1723;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1723;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1723;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1723;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1723;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1723;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1723;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1723;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1723;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1723;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1723;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1723;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1723;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1723;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1723;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1723;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1723;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1723;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0902;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0902;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0902;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0902;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0902;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0902;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0902;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0902;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0902;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0902;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0902;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0902;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0902;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0902;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0902;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0902;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0902;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0902;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0902;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0902;;ac_e --> ;0.0;0.0 +EX_acald_e;b0902;;acald_e --> ;0.0;0.0 +EX_akg_e;b0902;;akg_e --> ;0.0;0.0 +EX_co2_e;b0902;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0902;;etoh_e --> ;0.0;0.0 +EX_for_e;b0902;;for_e --> ;0.0;0.0 +EX_fru_e;b0902;;fru_e --> ;0.0;0.0 +EX_fum_e;b0902;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0902;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0902;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0902;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0902;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0902;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0902;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0902;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0902;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0902;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0902;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0902;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0902;;succ_e --> ;0.0;0.0 +FBA;b0902;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0902;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0902;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0902;;for_c --> for_e;0.0;0.0 +FRD7;b0902;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0902;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0902;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0902;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0902;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0902;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0902;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0902;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0902;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0902;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0902;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0902;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0902;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0902;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0902;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0902;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0902;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0902;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0902;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0902;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0902;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0902;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0902;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0902;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0902;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0902;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0902;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0902;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0902;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0902;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0902;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0902;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0902;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0902;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0902;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0902;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0902;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0902;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0902;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0902;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0902;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0902;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0902;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0902;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0902;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0902;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0902;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0902;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0902;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0902;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0902;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0902;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0903;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0903;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0903;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0903;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0903;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0903;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0903;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0903;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0903;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0903;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0903;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0903;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0903;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0903;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0903;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0903;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0903;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0903;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0903;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0903;;ac_e --> ;0.0;0.0 +EX_acald_e;b0903;;acald_e --> ;0.0;0.0 +EX_akg_e;b0903;;akg_e --> ;0.0;0.0 +EX_co2_e;b0903;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0903;;etoh_e --> ;0.0;0.0 +EX_for_e;b0903;;for_e --> ;0.0;0.0 +EX_fru_e;b0903;;fru_e --> ;0.0;0.0 +EX_fum_e;b0903;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0903;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0903;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0903;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0903;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0903;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0903;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0903;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0903;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0903;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0903;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0903;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0903;;succ_e --> ;0.0;0.0 +FBA;b0903;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0903;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0903;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0903;;for_c --> for_e;0.0;0.0 +FRD7;b0903;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0903;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0903;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0903;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0903;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0903;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0903;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0903;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0903;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0903;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0903;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0903;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0903;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0903;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0903;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0903;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0903;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0903;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0903;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0903;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0903;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0903;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0903;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0903;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0903;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0903;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0903;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0903;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0903;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0903;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0903;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0903;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0903;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0903;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0903;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0903;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0903;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0903;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0903;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0903;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0903;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0903;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0903;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0903;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0903;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0903;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0903;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0903;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0903;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0903;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0903;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0903;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2579;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2579;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2579;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2579;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2579;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2579;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2579;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2579;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2579;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2579;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2579;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2579;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2579;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2579;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2579;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2579;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2579;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2579;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2579;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2579;;ac_e --> ;0.0;0.0 +EX_acald_e;b2579;;acald_e --> ;0.0;0.0 +EX_akg_e;b2579;;akg_e --> ;0.0;0.0 +EX_co2_e;b2579;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2579;;etoh_e --> ;0.0;0.0 +EX_for_e;b2579;;for_e --> ;0.0;0.0 +EX_fru_e;b2579;;fru_e --> ;0.0;0.0 +EX_fum_e;b2579;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2579;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2579;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2579;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2579;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2579;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2579;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2579;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2579;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2579;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2579;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2579;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2579;;succ_e --> ;0.0;0.0 +FBA;b2579;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2579;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2579;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2579;;for_c --> for_e;0.0;0.0 +FRD7;b2579;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2579;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2579;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2579;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2579;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2579;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2579;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2579;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2579;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2579;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2579;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2579;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2579;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2579;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2579;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2579;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2579;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2579;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2579;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2579;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2579;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2579;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2579;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2579;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2579;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2579;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2579;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2579;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2579;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2579;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2579;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2579;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2579;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2579;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2579;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2579;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2579;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2579;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2579;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2579;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2579;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2579;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2579;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2579;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2579;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2579;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2579;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2579;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2579;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2579;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2579;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2579;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3114;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3114;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3114;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3114;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3114;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3114;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3114;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3114;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3114;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3114;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3114;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3114;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3114;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3114;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3114;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3114;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3114;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3114;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3114;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3114;;ac_e --> ;0.0;0.0 +EX_acald_e;b3114;;acald_e --> ;0.0;0.0 +EX_akg_e;b3114;;akg_e --> ;0.0;0.0 +EX_co2_e;b3114;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3114;;etoh_e --> ;0.0;0.0 +EX_for_e;b3114;;for_e --> ;0.0;0.0 +EX_fru_e;b3114;;fru_e --> ;0.0;0.0 +EX_fum_e;b3114;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3114;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3114;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3114;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3114;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3114;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3114;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3114;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3114;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3114;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3114;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3114;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3114;;succ_e --> ;0.0;0.0 +FBA;b3114;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3114;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3114;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3114;;for_c --> for_e;0.0;0.0 +FRD7;b3114;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3114;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3114;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3114;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3114;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3114;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3114;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3114;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3114;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3114;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3114;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3114;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3114;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3114;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3114;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3114;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3114;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3114;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3114;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3114;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3114;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3114;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3114;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3114;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3114;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3114;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3114;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3114;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3114;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3114;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3114;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3114;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3114;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3114;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3114;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3114;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3114;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3114;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3114;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3114;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3114;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3114;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3114;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3114;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3114;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3114;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3114;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3114;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3114;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3114;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3114;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3114;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3952;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3952;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3952;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3952;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3952;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3952;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3952;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3952;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3952;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3952;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3952;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3952;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3952;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3952;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3952;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3952;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3952;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3952;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3952;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3952;;ac_e --> ;0.0;0.0 +EX_acald_e;b3952;;acald_e --> ;0.0;0.0 +EX_akg_e;b3952;;akg_e --> ;0.0;0.0 +EX_co2_e;b3952;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3952;;etoh_e --> ;0.0;0.0 +EX_for_e;b3952;;for_e --> ;0.0;0.0 +EX_fru_e;b3952;;fru_e --> ;0.0;0.0 +EX_fum_e;b3952;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3952;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3952;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3952;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3952;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3952;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3952;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3952;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3952;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3952;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3952;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3952;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3952;;succ_e --> ;0.0;0.0 +FBA;b3952;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3952;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3952;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3952;;for_c --> for_e;0.0;0.0 +FRD7;b3952;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3952;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3952;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3952;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3952;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3952;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3952;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3952;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3952;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3952;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3952;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3952;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3952;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3952;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3952;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3952;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3952;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3952;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3952;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3952;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3952;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3952;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3952;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3952;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3952;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3952;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3952;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3952;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3952;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3952;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3952;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3952;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3952;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3952;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3952;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3952;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3952;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3952;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3952;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3952;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3952;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3952;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3952;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3952;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3952;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3952;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3952;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3952;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3952;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3952;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3952;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3952;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3951;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3951;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3951;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3951;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3951;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3951;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3951;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3951;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3951;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3951;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3951;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3951;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3951;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3951;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3951;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3951;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3951;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3951;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3951;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3951;;ac_e --> ;0.0;0.0 +EX_acald_e;b3951;;acald_e --> ;0.0;0.0 +EX_akg_e;b3951;;akg_e --> ;0.0;0.0 +EX_co2_e;b3951;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3951;;etoh_e --> ;0.0;0.0 +EX_for_e;b3951;;for_e --> ;0.0;0.0 +EX_fru_e;b3951;;fru_e --> ;0.0;0.0 +EX_fum_e;b3951;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3951;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3951;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3951;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3951;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3951;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3951;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3951;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3951;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3951;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3951;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3951;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3951;;succ_e --> ;0.0;0.0 +FBA;b3951;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3951;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3951;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3951;;for_c --> for_e;0.0;0.0 +FRD7;b3951;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3951;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3951;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3951;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3951;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3951;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3951;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3951;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3951;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3951;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3951;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3951;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3951;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3951;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3951;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3951;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3951;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3951;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3951;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3951;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3951;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3951;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3951;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3951;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3951;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3951;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3951;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3951;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3951;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3951;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3951;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3951;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3951;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3951;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3951;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3951;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3951;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3951;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3951;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3951;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3951;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3951;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3951;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3951;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3951;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3951;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3951;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3951;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3951;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3951;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3951;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3951;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4025;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4025;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4025;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4025;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;4.538181622705607 +ACONTb;b4025;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;4.538181622705607 +ACt2r;b4025;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4025;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4025;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;3.6069187818279422 +AKGt2r;b4025;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4025;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4025;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4025;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.84702679234286 +Biomass_Ecoli_core;b4025;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8631595522084181 +CO2t;b4025;;co2_e <=> co2_c;-22.809833310205086;-23.267813675994688 +CS;b4025;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;4.538181622705607 +CYTBD;b4025;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.53982983537307 +D_LACt2;b4025;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4025;;2pg_c <=> h2o_c + pep_c;14.716139568742859;13.139825508328153 +ETOHt2r;b4025;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4025;;ac_e --> ;0.0;0.0 +EX_acald_e;b4025;;acald_e --> ;0.0;0.0 +EX_akg_e;b4025;;akg_e --> ;0.0;0.0 +EX_co2_e;b4025;;co2_e <=> ;22.809833310205086;23.267813675994688 +EX_etoh_e;b4025;;etoh_e --> ;0.0;0.0 +EX_for_e;b4025;;for_e --> ;0.0;0.0 +EX_fru_e;b4025;;fru_e --> ;0.0;0.0 +EX_fum_e;b4025;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4025;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4025;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4025;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4025;;h_e <=> ;17.530865429786523;17.31498061730091 +EX_h2o_e;b4025;;h2o_e <=> ;29.175827135565836;29.55541311810171 +EX_lac__D_e;b4025;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4025;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4025;;nh4_e <=> ;-4.765319193197444;-4.706636406282061 +EX_o2_e;b4025;;o2_e <=> ;-21.799492655998886;-22.26991491768653 +EX_pi_e;b4025;;pi_e <=> ;-3.214895047684769;-3.175305044709139 +EX_pyr_e;b4025;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4025;;succ_e --> ;0.0;0.0 +FBA;b4025;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;5.867064429485867 +FBP;b4025;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4025;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4025;;for_c --> for_e;0.0;0.0 +FRD7;b4025;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4025;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4025;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;3.6069187818279422 +FUMt2_2;b4025;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4025;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;9.823052291797264 +GAPD;b4025;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;14.431112198431945 +GLCpts;b4025;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4025;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22070989749969247 +GLNabc;b4025;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4025;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.485926508782369 +GLUN;b4025;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4025;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4025;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4025;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;9.82305229179726 +H2Ot;b4025;;h2o_e <=> h2o_c;-29.175827135565836;-29.55541311810171 +ICDHyr;b4025;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;4.538181622705607 +ICL;b4025;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4025;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4025;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4025;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4025;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;3.6069187818279422 +ME1;b4025;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4025;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4025;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.93291105354512 +NADTRHD;b4025;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;8.453203367301713 +NH4t;b4025;;nh4_e <=> nh4_c;4.765319193197444;4.706636406282061 +O2t;b4025;;o2_e <=> o2_c;21.799492655998886;22.26991491768653 +PDH;b4025;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;7.773130992472316 +PFK;b4025;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;5.867064429485868 +PFL;b4025;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4025;;g6p_c --> f6p_c;4.860861146496871;0.0 +PGK;b4025;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-14.431112198431947 +PGL;b4025;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;9.823052291797262 +PGM;b4025;;2pg_c <=> 3pg_c;-14.716139568742859;-13.139825508328153 +PIt2r;b4025;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.175305044709139 +PPC;b4025;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.4734700128084395 +PPCK;b4025;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4025;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4025;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4025;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.2182893719683217 +PYRt2;b4025;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4025;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;5.928262441737431 +RPI;b4025;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-3.894789850059832 +SUCCt2_2;b4025;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4025;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4025;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;3.6069187818279422 +SUCOAS;b4025;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-3.6069187818279422 +TALA;b4025;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;3.1199315200423348 +THD2;b4025;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4025;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;3.1199315200423343 +TKT2;b4025;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;2.808330921695096 +TPI;b4025;;dhap_c <=> g3p_c;7.477381962160304;5.867064429485867 +ACALD;b2926;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2926;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2926;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2926;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;-2.3338418216545344e-17 +ACONTb;b2926;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;-2.3338418216545313e-17 +ACt2r;b2926;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2926;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.6453846153846164 +AKGDH;b2926;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b2926;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2926;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2926;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2926;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;9.680769230769242 +Biomass_Ecoli_core;b2926;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;1.4471852414284364e-16 +CO2t;b2926;;co2_e <=> co2_c;-22.809833310205086;-3.872307692307697 +CS;b2926;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;-2.3338418216545344e-17 +CYTBD;b2926;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;7.7446153846153925 +D_LACt2;b2926;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2926;;2pg_c <=> h2o_c + pep_c;14.716139568742859;-2.1649891211769406e-16 +ETOHt2r;b2926;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2926;;ac_e --> ;0.0;0.0 +EX_acald_e;b2926;;acald_e --> ;0.0;0.0 +EX_akg_e;b2926;;akg_e --> ;0.0;0.0 +EX_co2_e;b2926;;co2_e <=> ;22.809833310205086;3.872307692307697 +EX_etoh_e;b2926;;etoh_e --> ;0.0;0.0 +EX_for_e;b2926;;for_e --> ;0.0;0.0 +EX_fru_e;b2926;;fru_e --> ;0.0;0.0 +EX_fum_e;b2926;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2926;;glc__D_e <=> ;-10.0;-0.6453846153846179 +EX_gln__L_e;b2926;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2926;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2926;;h_e <=> ;17.530865429786523;0.0 +EX_h2o_e;b2926;;h2o_e <=> ;29.175827135565836;3.872307692307699 +EX_lac__D_e;b2926;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2926;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2926;;nh4_e <=> ;-4.765319193197444;-7.891211684460975e-16 +EX_o2_e;b2926;;o2_e <=> ;-21.799492655998886;-3.872307692307696 +EX_pi_e;b2926;;pi_e <=> ;-3.214895047684769;8.058228228858859e-15 +EX_pyr_e;b2926;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2926;;succ_e --> ;0.0;0.0 +FBA;b2926;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;-0.6453846153846151 +FBP;b2926;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.6453846153846151 +FORt2;b2926;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2926;;for_c --> for_e;0.0;0.0 +FRD7;b2926;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2926;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2926;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.3830525039608783e-16 +FUMt2_2;b2926;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2926;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;3.8723076923076976 +GAPD;b2926;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;0.0 +GLCpts;b2926;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.6453846153846172 +GLNS;b2926;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;3.700452662332512e-17 +GLNabc;b2926;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2926;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-7.521166418227726e-16 +GLUN;b2926;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2926;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2926;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2926;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;3.8723076923076976 +H2Ot;b2926;;h2o_e <=> h2o_c;-29.175827135565836;-3.872307692307699 +ICDHyr;b2926;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;2.849877858256459e-16 +ICL;b2926;;icit_c --> glx_c + succ_c;0.0;-3.0832620404219124e-16 +LDH_D;b2926;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2926;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-3.0832620404219124e-16 +MALt2_2;b2926;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2926;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;1.299790463538966e-16 +ME1;b2926;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2926;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2926;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;7.744615384615392 +NADTRHD;b2926;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;7.74461538461539 +NH4t;b2926;;nh4_e <=> nh4_c;4.765319193197444;7.891211684460975e-16 +O2t;b2926;;o2_e <=> o2_c;21.799492655998886;3.872307692307696 +PDH;b2926;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0 +PFK;b2926;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.0 +PFL;b2926;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2926;;g6p_c <=> f6p_c;4.860861146496871;-3.2269230769230806 +PGK;b2926;;3pg_c + atp_c --> 13dpg_c + adp_c;-16.02352614316763;0.0 +PGL;b2926;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;3.872307692307698 +PGM;b2926;;2pg_c <=> 3pg_c;-14.716139568742859;2.1649891211769406e-16 +PIt2r;b2926;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;-8.058228228858859e-15 +PPC;b2926;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.0525112251557681e-16 +PPCK;b2926;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2926;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.6453846153846164 +PTAr;b2926;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2926;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b2926;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2926;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.581538461538465 +RPI;b2926;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-1.290769230769233 +SUCCt2_2;b2926;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2926;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2926;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.3830525039608783e-16 +SUCOAS;b2926;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-7.466314544382791e-16 +TALA;b2926;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.2907692307692327 +THD2;b2926;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2926;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.2907692307692327 +TKT2;b2926;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.2907692307692327 +TPI;b2926;;dhap_c <=> g3p_c;7.477381962160304;-0.6453846153846151 +ACALD;b0767;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0767;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0767;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0767;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;7.80330159512732 +ACONTb;b0767;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;7.80330159512732 +ACt2r;b0767;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0767;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0767;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;6.871333415503455 +AKGt2r;b0767;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0767;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0767;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0767;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;41.35354605121257 +Biomass_Ecoli_core;b0767;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8638133095040013 +CO2t;b0767;;co2_e <=> co2_c;-22.809833310205086;-23.239992707402532 +CS;b0767;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;7.803301595127319 +CYTBD;b0767;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.4826762805699 +D_LACt2;b0767;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0767;;2pg_c <=> h2o_c + pep_c;14.716139568742859;16.41146036832753 +ETOHt2r;b0767;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0767;;ac_e --> ;0.0;0.0 +EX_acald_e;b0767;;acald_e --> ;0.0;0.0 +EX_akg_e;b0767;;akg_e --> ;0.0;0.0 +EX_co2_e;b0767;;co2_e <=> ;22.809833310205086;23.239992707402532 +EX_etoh_e;b0767;;etoh_e --> ;0.0;0.0 +EX_for_e;b0767;;for_e --> ;0.0;0.0 +EX_fru_e;b0767;;fru_e --> ;0.0;0.0 +EX_fum_e;b0767;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0767;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0767;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0767;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0767;;h_e <=> ;17.530865429786523;17.328094988650253 +EX_h2o_e;b0767;;h2o_e <=> ;29.175827135565836;29.53235437915348 +EX_lac__D_e;b0767;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0767;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0767;;nh4_e <=> ;-4.765319193197444;-4.710201214063416 +EX_o2_e;b0767;;o2_e <=> ;-21.799492655998886;-22.241338140284945 +EX_pi_e;b0767;;pi_e <=> ;-3.214895047684769;-3.1777100216723944 +EX_pyr_e;b0767;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0767;;succ_e --> ;0.0;0.0 +FBA;b0767;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.14076490103637 +FBP;b0767;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0767;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0767;;for_c --> for_e;0.0;0.0 +FRD7;b0767;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0767;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0767;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;6.871333415503455 +FUMt2_2;b0767;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0767;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;1.5294541852809653e-14 +GAPD;b0767;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;17.703725079345514 +GLCpts;b0767;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000005 +GLNS;b0767;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2208770632401731 +GLNabc;b0767;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0767;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.4893241508232435 +GLUN;b0767;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0767;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0767;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0767;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;1.5294541852809653e-14 +H2Ot;b0767;;h2o_e <=> h2o_c;-29.175827135565836;-29.53235437915348 +ICDHyr;b0767;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;7.80330159512732 +ICL;b0767;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0767;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0767;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0767;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0767;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;6.871333415503455 +ME1;b0767;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0767;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0767;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;37.61134286506644 +NADTRHD;b0767;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0767;;nh4_e <=> nh4_c;4.765319193197444;4.710201214063416 +O2t;b0767;;o2_e <=> o2_c;21.799492655998886;22.241338140284945 +PDH;b0767;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.040701116486408 +PFK;b0767;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.140764901036375 +PFL;b0767;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0767;;g6p_c <=> f6p_c;4.860861146496871;9.822918271551679 +PGK;b0767;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-17.703725079345517 +PGL;b0767;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0 +PGM;b0767;;2pg_c <=> 3pg_c;-14.716139568742859;-16.41146036832753 +PIt2r;b0767;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1777100216723944 +PPC;b0767;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.475343419714662 +PPCK;b0767;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0767;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0767;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0767;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.4877114596493364 +PYRt2;b0767;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0767;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.6209090068714703 +RPI;b0767;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.6209090068714856 +SUCCt2_2;b0767;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0767;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0767;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;6.871333415503455 +SUCOAS;b0767;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-6.871333415503455 +TALA;b0767;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.15453620107026306 +THD2;b0767;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;7.939695970583087 +TKT1;b0767;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.15453620107026306 +TKT2;b0767;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.4663728058012074 +TPI;b0767;;dhap_c <=> g3p_c;7.477381962160304;9.14076490103637 +ACALD;b0755;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0755;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0755;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0755;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350332 +ACONTb;b0755;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325 +ACt2r;b0755;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0755;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0755;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096 +AKGt2r;b0755;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0755;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0755;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0755;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451748 +Biomass_Ecoli_core;b0755;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684311 +CO2t;b0755;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0755;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350331 +CYTBD;b0755;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754 +D_LACt2;b0755;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0755;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283 +ETOHt2r;b0755;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0755;;ac_e --> ;0.0;0.0 +EX_acald_e;b0755;;acald_e --> ;0.0;0.0 +EX_akg_e;b0755;;akg_e --> ;0.0;0.0 +EX_co2_e;b0755;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0755;;etoh_e --> ;0.0;0.0 +EX_for_e;b0755;;for_e --> ;0.0;0.0 +EX_fru_e;b0755;;fru_e --> ;0.0;0.0 +EX_fum_e;b0755;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0755;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0755;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0755;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0755;;h_e <=> ;17.530865429786523;17.530865429786658 +EX_h2o_e;b0755;;h2o_e <=> ;29.175827135565836;29.1758271355658 +EX_lac__D_e;b0755;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0755;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0755;;nh4_e <=> ;-4.765319193197444;-4.76531919319746 +EX_o2_e;b0755;;o2_e <=> ;-21.799492655998886;-21.799492655998765 +EX_pi_e;b0755;;pi_e <=> ;-3.214895047684769;-3.2148950476847737 +EX_pyr_e;b0755;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0755;;succ_e --> ;0.0;0.0 +FBA;b0755;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.4773819621602815 +FBP;b0755;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0755;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0755;;for_c --> for_e;0.0;0.0 +FRD7;b0755;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0755;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0755;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482096 +FUMt2_2;b0755;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0755;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574661 +GAPD;b0755;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604 +GLCpts;b0755;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0755;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182779 +GLNabc;b0755;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0755;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632 +GLUN;b0755;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0755;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0755;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0755;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574659 +H2Ot;b0755;;h2o_e <=> h2o_c;-29.175827135565836;-29.1758271355658 +ICDHyr;b0755;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350332 +ICL;b0755;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0755;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0755;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0755;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0755;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482096 +ME1;b0755;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0755;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0755;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0755;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0755;;nh4_e <=> nh4_c;4.765319193197444;4.76531919319746 +O2t;b0755;;o2_e <=> o2_c;21.799492655998886;21.799492655998765 +PDH;b0755;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166617 +PFK;b0755;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160282 +PFL;b0755;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0755;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496813 +PGK;b0755;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608 +PGL;b0755;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.95998494457466 +PGM;b0755;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283 +PIt2r;b0755;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847737 +PPC;b0755;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368731 +PPCK;b0755;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0755;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0755;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0755;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067861 +PYRt2;b0755;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0755;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075307 +RPI;b0755;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067128 +SUCCt2_2;b0755;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0755;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0755;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097 +SUCOAS;b0755;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097 +TALA;b0755;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615676 +THD2;b0755;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0755;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615674 +TKT2;b0755;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245964 +TPI;b0755;;dhap_c <=> g3p_c;7.477381962160304;7.4773819621602815 +ACALD;b3612;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3612;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3612;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3612;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3612;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3612;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3612;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3612;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3612;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3612;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3612;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3612;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3612;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3612;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3612;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3612;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3612;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3612;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3612;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3612;;ac_e --> ;0.0;0.0 +EX_acald_e;b3612;;acald_e --> ;0.0;0.0 +EX_akg_e;b3612;;akg_e --> ;0.0;0.0 +EX_co2_e;b3612;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3612;;etoh_e --> ;0.0;0.0 +EX_for_e;b3612;;for_e --> ;0.0;0.0 +EX_fru_e;b3612;;fru_e --> ;0.0;0.0 +EX_fum_e;b3612;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3612;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3612;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3612;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3612;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3612;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3612;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3612;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3612;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3612;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3612;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3612;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3612;;succ_e --> ;0.0;0.0 +FBA;b3612;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3612;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3612;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3612;;for_c --> for_e;0.0;0.0 +FRD7;b3612;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3612;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3612;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3612;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3612;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3612;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3612;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3612;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3612;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3612;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3612;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3612;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3612;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3612;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3612;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3612;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3612;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3612;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3612;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3612;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3612;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3612;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3612;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3612;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3612;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3612;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3612;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3612;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3612;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3612;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3612;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3612;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3612;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3612;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3612;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3612;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3612;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3612;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3612;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3612;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3612;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3612;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3612;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3612;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3612;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3612;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3612;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3612;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3612;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3612;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3612;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3612;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4395;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4395;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4395;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4395;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4395;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4395;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4395;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4395;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4395;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4395;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4395;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4395;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4395;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4395;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4395;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4395;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4395;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4395;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4395;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4395;;ac_e --> ;0.0;0.0 +EX_acald_e;b4395;;acald_e --> ;0.0;0.0 +EX_akg_e;b4395;;akg_e --> ;0.0;0.0 +EX_co2_e;b4395;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4395;;etoh_e --> ;0.0;0.0 +EX_for_e;b4395;;for_e --> ;0.0;0.0 +EX_fru_e;b4395;;fru_e --> ;0.0;0.0 +EX_fum_e;b4395;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4395;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4395;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4395;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4395;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4395;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4395;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4395;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4395;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4395;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4395;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4395;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4395;;succ_e --> ;0.0;0.0 +FBA;b4395;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4395;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4395;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4395;;for_c --> for_e;0.0;0.0 +FRD7;b4395;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4395;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4395;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4395;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4395;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4395;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4395;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4395;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4395;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4395;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4395;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4395;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4395;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4395;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4395;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4395;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4395;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4395;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4395;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4395;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4395;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4395;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4395;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4395;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4395;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4395;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4395;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4395;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4395;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4395;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4395;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4395;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4395;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4395;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4395;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4395;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4395;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4395;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4395;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4395;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4395;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4395;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4395;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4395;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4395;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4395;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4395;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4395;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4395;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4395;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4395;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4395;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3493;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3493;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3493;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3493;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3493;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3493;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3493;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3493;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3493;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3493;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3493;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3493;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3493;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3493;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3493;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3493;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3493;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3493;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3493;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3493;;ac_e --> ;0.0;0.0 +EX_acald_e;b3493;;acald_e --> ;0.0;0.0 +EX_akg_e;b3493;;akg_e --> ;0.0;0.0 +EX_co2_e;b3493;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3493;;etoh_e --> ;0.0;0.0 +EX_for_e;b3493;;for_e --> ;0.0;0.0 +EX_fru_e;b3493;;fru_e --> ;0.0;0.0 +EX_fum_e;b3493;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3493;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3493;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3493;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3493;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3493;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3493;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3493;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3493;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3493;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3493;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3493;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3493;;succ_e --> ;0.0;0.0 +FBA;b3493;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3493;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3493;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3493;;for_c --> for_e;0.0;0.0 +FRD7;b3493;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3493;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3493;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3493;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3493;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3493;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3493;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3493;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3493;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3493;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3493;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3493;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3493;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3493;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3493;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3493;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3493;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3493;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3493;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3493;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3493;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3493;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3493;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3493;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3493;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3493;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3493;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3493;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3493;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3493;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3493;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3493;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3493;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3493;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3493;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3493;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3493;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3493;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3493;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3493;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3493;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3493;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3493;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3493;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3493;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3493;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3493;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3493;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3493;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3493;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3493;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3493;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2987;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2987;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2987;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2987;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2987;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2987;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2987;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2987;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2987;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2987;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2987;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2987;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2987;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2987;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2987;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2987;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2987;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2987;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2987;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2987;;ac_e --> ;0.0;0.0 +EX_acald_e;b2987;;acald_e --> ;0.0;0.0 +EX_akg_e;b2987;;akg_e --> ;0.0;0.0 +EX_co2_e;b2987;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2987;;etoh_e --> ;0.0;0.0 +EX_for_e;b2987;;for_e --> ;0.0;0.0 +EX_fru_e;b2987;;fru_e --> ;0.0;0.0 +EX_fum_e;b2987;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2987;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2987;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2987;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2987;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2987;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2987;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2987;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2987;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2987;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2987;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2987;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2987;;succ_e --> ;0.0;0.0 +FBA;b2987;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2987;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2987;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2987;;for_c --> for_e;0.0;0.0 +FRD7;b2987;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2987;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2987;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2987;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2987;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2987;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2987;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2987;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2987;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2987;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2987;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2987;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2987;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2987;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2987;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2987;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2987;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2987;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2987;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2987;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2987;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2987;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2987;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2987;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2987;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2987;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2987;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2987;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2987;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2987;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2987;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2987;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2987;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2987;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2987;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2987;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2987;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2987;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2987;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2987;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2987;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2987;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2987;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2987;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2987;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2987;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2987;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2987;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2987;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2987;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2987;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2987;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3956;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3956;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3956;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3956;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.573611878986723 +ACONTb;b3956;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.573611878986724 +ACt2r;b3956;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3956;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3956;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;2.1389589908676214 +AKGt2r;b3956;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3956;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3956;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3956;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;46.20266690801874 +Biomass_Ecoli_core;b3956;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8707448062160257 +CO2t;b3956;;co2_e <=> co2_c;-22.809833310205086;-22.945019399073974 +CS;b3956;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.573611878986723 +CYTBD;b3956;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.87670265721525 +D_LACt2;b3956;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3956;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.250845096371272 +ETOHt2r;b3956;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3956;;ac_e --> ;0.0;0.0 +EX_acald_e;b3956;;acald_e --> ;0.0;0.0 +EX_akg_e;b3956;;akg_e --> ;0.0;0.0 +EX_co2_e;b3956;;co2_e <=> ;22.809833310205086;22.945019399073974 +EX_etoh_e;b3956;;etoh_e --> ;0.0;0.0 +EX_for_e;b3956;;for_e --> ;0.0;0.0 +EX_fru_e;b3956;;fru_e --> ;0.0;0.0 +EX_fum_e;b3956;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3956;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3956;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3956;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3956;;h_e <=> ;17.530865429786523;17.467140812693557 +EX_h2o_e;b3956;;h2o_e <=> ;29.175827135565836;29.287872865473975 +EX_lac__D_e;b3956;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3956;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3956;;nh4_e <=> ;-4.765319193197444;-4.747997279334743 +EX_o2_e;b3956;;o2_e <=> ;-21.799492655998886;-21.93835132860762 +EX_pi_e;b3956;;pi_e <=> ;-3.214895047684769;-3.2032089186269213 +EX_pyr_e;b3956;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3956;;succ_e --> ;0.0;0.0 +FBA;b3956;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.002050386091425 +FBP;b3956;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3956;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3956;;for_c --> for_e;0.0;0.0 +FRD7;b3956;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3956;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3956;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.634165307560258 +FUMt2_2;b3956;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3956;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.3954592654964895 +GAPD;b3956;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.553479326470448 +GLCpts;b3956;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3956;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22264944694943775 +GLNabc;b3956;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3956;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.525347832385306 +GLUN;b3956;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3956;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3956;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3956;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.395459265496489 +H2Ot;b3956;;h2o_e <=> h2o_c;-29.175827135565836;-29.287872865473975 +ICDHyr;b3956;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;3.0784055622940882 +ICL;b3956;;icit_c --> glx_c + succ_c;0.0;2.4952063166926357 +LDH_D;b3956;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3956;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;2.4952063166926357 +MALt2_2;b3956;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3956;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.129371624252893 +ME1;b3956;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3956;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3956;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;39.24253734965499 +NADTRHD;b3956;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3956;;nh4_e <=> nh4_c;4.765319193197444;4.747997279334743 +O2t;b3956;;o2_e <=> o2_c;21.799492655998886;21.93835132860762 +PDH;b3956;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.332195580415782 +PFK;b3956;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.002050386091425 +PFL;b3956;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3956;;g6p_c <=> f6p_c;4.860861146496871;3.4260380492292266 +PGK;b3956;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.55347932647045 +PGL;b3956;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.3954592654964895 +PGM;b3956;;2pg_c <=> 3pg_c;-14.716139568742859;-14.250845096371272 +PIt2r;b3956;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2032089186269213 +PPC;b3956;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0 +PPCK;b3956;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3956;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3956;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3956;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.798841467464536 +PYRt2;b3956;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3956;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.6377481436229133 +RPI;b3956;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.757711121873576 +SUCCt2_2;b3956;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3956;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3956;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.634165307560258 +SUCOAS;b3956;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-2.1389589908676214 +TALA;b3956;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.9760435093334492 +THD2;b3956;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3956;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.976043509333449 +TKT2;b3956;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.6617046342894641 +TPI;b3956;;dhap_c <=> g3p_c;7.477381962160304;7.002050386091425 +ACALD;b3403;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3403;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3403;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3403;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.0072495753503246 +ACONTb;b3403;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503246 +ACt2r;b3403;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3403;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3403;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482091 +AKGt2r;b3403;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3403;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3403;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3403;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451743 +Biomass_Ecoli_core;b3403;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684311 +CO2t;b3403;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204958 +CS;b3403;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.0072495753503246 +CYTBD;b3403;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.598985311997495 +D_LACt2;b3403;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3403;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742825 +ETOHt2r;b3403;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3403;;ac_e --> ;0.0;0.0 +EX_acald_e;b3403;;acald_e --> ;0.0;0.0 +EX_akg_e;b3403;;akg_e --> ;0.0;0.0 +EX_co2_e;b3403;;co2_e <=> ;22.809833310205086;22.809833310204958 +EX_etoh_e;b3403;;etoh_e --> ;0.0;0.0 +EX_for_e;b3403;;for_e --> ;0.0;0.0 +EX_fru_e;b3403;;fru_e --> ;0.0;0.0 +EX_fum_e;b3403;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3403;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3403;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3403;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3403;;h_e <=> ;17.530865429786523;17.530865429786765 +EX_h2o_e;b3403;;h2o_e <=> ;29.175827135565836;29.175827135565715 +EX_lac__D_e;b3403;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3403;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3403;;nh4_e <=> ;-4.765319193197444;-4.76531919319746 +EX_o2_e;b3403;;o2_e <=> ;-21.799492655998886;-21.79949265599874 +EX_pi_e;b3403;;pi_e <=> ;-3.214895047684769;-3.2148950476846583 +EX_pyr_e;b3403;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3403;;succ_e --> ;0.0;0.0 +FBA;b3403;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.47738196216028 +FBP;b3403;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3403;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3403;;for_c --> for_e;0.0;0.0 +FRD7;b3403;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3403;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3403;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482089 +FUMt2_2;b3403;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3403;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574666 +GAPD;b3403;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167597 +GLCpts;b3403;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3403;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182779 +GLNabc;b3403;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3403;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632 +GLUN;b3403;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3403;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3403;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3403;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574665 +H2Ot;b3403;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565715 +ICDHyr;b3403;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350328 +ICL;b3403;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3403;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3403;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-3.2834795302282726e-15 +MALt2_2;b3403;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3403;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482085 +ME1;b3403;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3403;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3403;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.5346096505154 +NADTRHD;b3403;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3403;;nh4_e <=> nh4_c;4.765319193197444;4.76531919319746 +O2t;b3403;;o2_e <=> o2_c;21.799492655998886;21.79949265599874 +PDH;b3403;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166606 +PFK;b3403;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.47738196216028 +PFL;b3403;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3403;;g6p_c <=> f6p_c;4.860861146496871;4.8608611464968075 +PGK;b3403;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.0235261431676 +PGL;b3403;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574666 +PGM;b3403;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742825 +PIt2r;b3403;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476846583 +PPC;b3403;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687347 +PPCK;b3403;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3403;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3403;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3403;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067755 +PYRt2;b3403;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3403;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075347 +RPI;b3403;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067131 +SUCCt2_2;b3403;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3403;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3403;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482089 +SUCOAS;b3403;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482091 +TALA;b3403;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615692 +THD2;b3403;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3403;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615692 +TKT2;b3403;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459658 +TPI;b3403;;dhap_c <=> g3p_c;7.477381962160304;7.47738196216028 +ACALD;b1702;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1702;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1702;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1702;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1702;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1702;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1702;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1702;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1702;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1702;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1702;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1702;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1702;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1702;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1702;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1702;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1702;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1702;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1702;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1702;;ac_e --> ;0.0;0.0 +EX_acald_e;b1702;;acald_e --> ;0.0;0.0 +EX_akg_e;b1702;;akg_e --> ;0.0;0.0 +EX_co2_e;b1702;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1702;;etoh_e --> ;0.0;0.0 +EX_for_e;b1702;;for_e --> ;0.0;0.0 +EX_fru_e;b1702;;fru_e --> ;0.0;0.0 +EX_fum_e;b1702;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1702;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1702;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1702;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1702;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1702;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1702;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1702;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1702;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1702;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1702;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1702;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1702;;succ_e --> ;0.0;0.0 +FBA;b1702;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1702;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1702;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1702;;for_c --> for_e;0.0;0.0 +FRD7;b1702;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1702;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1702;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1702;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1702;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1702;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1702;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1702;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1702;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1702;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1702;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1702;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1702;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1702;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1702;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1702;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1702;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1702;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1702;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1702;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1702;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1702;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1702;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1702;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1702;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1702;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1702;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1702;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1702;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1702;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1702;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1702;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1702;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1702;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1702;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1702;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1702;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1702;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1702;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1702;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1702;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1702;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1702;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1702;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1702;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1702;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1702;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1702;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1702;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1702;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1702;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1702;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2297;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2297;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2297;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2297;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2297;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2297;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2297;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2297;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2297;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2297;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2297;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2297;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2297;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2297;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2297;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2297;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2297;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2297;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2297;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2297;;ac_e --> ;0.0;0.0 +EX_acald_e;b2297;;acald_e --> ;0.0;0.0 +EX_akg_e;b2297;;akg_e --> ;0.0;0.0 +EX_co2_e;b2297;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2297;;etoh_e --> ;0.0;0.0 +EX_for_e;b2297;;for_e --> ;0.0;0.0 +EX_fru_e;b2297;;fru_e --> ;0.0;0.0 +EX_fum_e;b2297;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2297;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2297;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2297;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2297;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2297;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2297;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2297;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2297;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2297;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2297;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2297;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2297;;succ_e --> ;0.0;0.0 +FBA;b2297;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2297;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2297;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2297;;for_c --> for_e;0.0;0.0 +FRD7;b2297;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2297;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2297;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2297;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2297;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2297;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2297;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2297;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2297;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2297;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2297;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2297;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2297;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2297;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2297;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2297;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2297;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2297;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2297;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2297;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2297;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2297;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2297;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2297;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2297;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2297;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2297;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2297;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2297;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2297;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2297;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2297;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2297;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2297;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2297;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2297;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2297;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2297;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2297;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2297;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2297;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2297;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2297;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2297;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2297;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2297;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2297;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2297;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2297;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2297;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2297;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2297;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2458;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2458;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2458;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2458;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2458;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2458;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2458;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2458;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2458;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2458;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2458;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2458;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2458;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2458;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2458;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2458;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2458;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2458;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2458;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2458;;ac_e --> ;0.0;0.0 +EX_acald_e;b2458;;acald_e --> ;0.0;0.0 +EX_akg_e;b2458;;akg_e --> ;0.0;0.0 +EX_co2_e;b2458;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2458;;etoh_e --> ;0.0;0.0 +EX_for_e;b2458;;for_e --> ;0.0;0.0 +EX_fru_e;b2458;;fru_e --> ;0.0;0.0 +EX_fum_e;b2458;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2458;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2458;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2458;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2458;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2458;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2458;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2458;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2458;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2458;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2458;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2458;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2458;;succ_e --> ;0.0;0.0 +FBA;b2458;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2458;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2458;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2458;;for_c --> for_e;0.0;0.0 +FRD7;b2458;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2458;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2458;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2458;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2458;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2458;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2458;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2458;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2458;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2458;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2458;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2458;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2458;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2458;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2458;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2458;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2458;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2458;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2458;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2458;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2458;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2458;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2458;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2458;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2458;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2458;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2458;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2458;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2458;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2458;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2458;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2458;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2458;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2458;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2458;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2458;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2458;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2458;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2458;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2458;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2458;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2458;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2458;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2458;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2458;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2458;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2458;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2458;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2458;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2458;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2458;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2458;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1676;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1676;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1676;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1676;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1676;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1676;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1676;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1676;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1676;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1676;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1676;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1676;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1676;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1676;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1676;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1676;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1676;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1676;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1676;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1676;;ac_e --> ;0.0;0.0 +EX_acald_e;b1676;;acald_e --> ;0.0;0.0 +EX_akg_e;b1676;;akg_e --> ;0.0;0.0 +EX_co2_e;b1676;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1676;;etoh_e --> ;0.0;0.0 +EX_for_e;b1676;;for_e --> ;0.0;0.0 +EX_fru_e;b1676;;fru_e --> ;0.0;0.0 +EX_fum_e;b1676;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1676;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1676;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1676;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1676;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1676;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1676;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1676;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1676;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1676;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1676;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1676;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1676;;succ_e --> ;0.0;0.0 +FBA;b1676;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1676;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1676;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1676;;for_c --> for_e;0.0;0.0 +FRD7;b1676;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1676;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1676;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1676;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1676;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1676;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1676;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1676;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1676;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1676;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1676;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1676;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1676;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1676;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1676;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1676;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1676;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1676;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1676;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1676;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1676;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1676;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1676;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1676;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1676;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1676;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1676;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1676;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1676;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1676;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1676;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1676;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1676;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1676;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1676;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1676;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1676;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1676;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1676;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1676;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1676;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1676;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1676;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1676;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1676;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1676;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1676;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1676;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1676;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1676;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1676;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1676;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b1854;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b1854;;acald_e <=> acald_c;0.0;0.0 +ACKr;b1854;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b1854;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b1854;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b1854;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b1854;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b1854;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b1854;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b1854;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b1854;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b1854;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b1854;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b1854;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b1854;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b1854;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b1854;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b1854;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b1854;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b1854;;ac_e --> ;0.0;0.0 +EX_acald_e;b1854;;acald_e --> ;0.0;0.0 +EX_akg_e;b1854;;akg_e --> ;0.0;0.0 +EX_co2_e;b1854;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b1854;;etoh_e --> ;0.0;0.0 +EX_for_e;b1854;;for_e --> ;0.0;0.0 +EX_fru_e;b1854;;fru_e --> ;0.0;0.0 +EX_fum_e;b1854;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b1854;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b1854;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b1854;;glu__L_e --> ;0.0;0.0 +EX_h_e;b1854;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b1854;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b1854;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b1854;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b1854;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b1854;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b1854;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b1854;;pyr_e --> ;0.0;0.0 +EX_succ_e;b1854;;succ_e --> ;0.0;0.0 +FBA;b1854;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b1854;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b1854;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b1854;;for_c --> for_e;0.0;0.0 +FRD7;b1854;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b1854;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b1854;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b1854;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b1854;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b1854;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b1854;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b1854;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b1854;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b1854;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b1854;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b1854;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b1854;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b1854;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b1854;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b1854;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b1854;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b1854;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b1854;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b1854;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b1854;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b1854;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b1854;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b1854;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b1854;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b1854;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b1854;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b1854;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b1854;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b1854;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b1854;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b1854;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b1854;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b1854;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b1854;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b1854;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b1854;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b1854;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b1854;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b1854;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b1854;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b1854;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b1854;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b1854;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b1854;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b1854;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b1854;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b1854;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b1854;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b1854;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b1854;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b1854;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4301;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4301;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4301;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4301;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4301;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4301;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4301;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4301;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4301;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4301;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4301;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4301;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4301;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4301;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4301;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4301;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4301;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4301;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4301;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4301;;ac_e --> ;0.0;0.0 +EX_acald_e;b4301;;acald_e --> ;0.0;0.0 +EX_akg_e;b4301;;akg_e --> ;0.0;0.0 +EX_co2_e;b4301;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4301;;etoh_e --> ;0.0;0.0 +EX_for_e;b4301;;for_e --> ;0.0;0.0 +EX_fru_e;b4301;;fru_e --> ;0.0;0.0 +EX_fum_e;b4301;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4301;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4301;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4301;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4301;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4301;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4301;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4301;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4301;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4301;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4301;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4301;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4301;;succ_e --> ;0.0;0.0 +FBA;b4301;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4301;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4301;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4301;;for_c --> for_e;0.0;0.0 +FRD7;b4301;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4301;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4301;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4301;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4301;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4301;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4301;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4301;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4301;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4301;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4301;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4301;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4301;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4301;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4301;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4301;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4301;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4301;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4301;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4301;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4301;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4301;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4301;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4301;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4301;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4301;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4301;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4301;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4301;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4301;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4301;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4301;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4301;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4301;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4301;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4301;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4301;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4301;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4301;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4301;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4301;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4301;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4301;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4301;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4301;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4301;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4301;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4301;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4301;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4301;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4301;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4301;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3386;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3386;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3386;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3386;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b3386;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b3386;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3386;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b3386;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b3386;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3386;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3386;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b3386;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b3386;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b3386;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b3386;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b3386;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b3386;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3386;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b3386;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3386;;ac_e --> ;0.0;0.0 +EX_acald_e;b3386;;acald_e --> ;0.0;0.0 +EX_akg_e;b3386;;akg_e --> ;0.0;0.0 +EX_co2_e;b3386;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b3386;;etoh_e --> ;0.0;0.0 +EX_for_e;b3386;;for_e --> ;0.0;0.0 +EX_fru_e;b3386;;fru_e --> ;0.0;0.0 +EX_fum_e;b3386;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3386;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3386;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3386;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3386;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b3386;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b3386;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3386;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3386;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b3386;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b3386;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b3386;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3386;;succ_e --> ;0.0;0.0 +FBA;b3386;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b3386;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3386;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3386;;for_c --> for_e;0.0;0.0 +FRD7;b3386;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3386;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3386;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b3386;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3386;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b3386;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b3386;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3386;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b3386;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3386;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b3386;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3386;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3386;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3386;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b3386;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b3386;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b3386;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3386;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3386;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3386;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3386;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b3386;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3386;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3386;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b3386;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b3386;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b3386;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b3386;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b3386;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b3386;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3386;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b3386;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b3386;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b3386;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b3386;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b3386;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b3386;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3386;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b3386;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3386;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b3386;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3386;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b3386;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b3386;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3386;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3386;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b3386;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b3386;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b3386;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3386;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b3386;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b3386;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2914;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2914;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2914;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2914;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2914;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2914;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2914;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2914;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2914;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2914;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2914;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2914;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2914;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2914;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2914;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2914;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2914;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2914;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2914;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2914;;ac_e --> ;0.0;0.0 +EX_acald_e;b2914;;acald_e --> ;0.0;0.0 +EX_akg_e;b2914;;akg_e --> ;0.0;0.0 +EX_co2_e;b2914;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2914;;etoh_e --> ;0.0;0.0 +EX_for_e;b2914;;for_e --> ;0.0;0.0 +EX_fru_e;b2914;;fru_e --> ;0.0;0.0 +EX_fum_e;b2914;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2914;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2914;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2914;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2914;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2914;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2914;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2914;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2914;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2914;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2914;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2914;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2914;;succ_e --> ;0.0;0.0 +FBA;b2914;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2914;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2914;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2914;;for_c --> for_e;0.0;0.0 +FRD7;b2914;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2914;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2914;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2914;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2914;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2914;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2914;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2914;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2914;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2914;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2914;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2914;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2914;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2914;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2914;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2914;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2914;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2914;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2914;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2914;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2914;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2914;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2914;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2914;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2914;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2914;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2914;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2914;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2914;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2914;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2914;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2914;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2914;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2914;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2914;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2914;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2914;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2914;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2914;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2914;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2914;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2914;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2914;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2914;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2914;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2914;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2914;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2914;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2914;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2914;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2914;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2914;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b4090;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b4090;;acald_e <=> acald_c;0.0;0.0 +ACKr;b4090;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b4090;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b4090;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b4090;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b4090;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b4090;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b4090;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b4090;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b4090;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b4090;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b4090;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b4090;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b4090;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b4090;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b4090;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b4090;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b4090;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b4090;;ac_e --> ;0.0;0.0 +EX_acald_e;b4090;;acald_e --> ;0.0;0.0 +EX_akg_e;b4090;;akg_e --> ;0.0;0.0 +EX_co2_e;b4090;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b4090;;etoh_e --> ;0.0;0.0 +EX_for_e;b4090;;for_e --> ;0.0;0.0 +EX_fru_e;b4090;;fru_e --> ;0.0;0.0 +EX_fum_e;b4090;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b4090;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b4090;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b4090;;glu__L_e --> ;0.0;0.0 +EX_h_e;b4090;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b4090;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b4090;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b4090;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b4090;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b4090;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b4090;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b4090;;pyr_e --> ;0.0;0.0 +EX_succ_e;b4090;;succ_e --> ;0.0;0.0 +FBA;b4090;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b4090;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b4090;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b4090;;for_c --> for_e;0.0;0.0 +FRD7;b4090;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b4090;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b4090;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b4090;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b4090;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b4090;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b4090;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b4090;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b4090;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b4090;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b4090;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b4090;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b4090;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b4090;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b4090;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b4090;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b4090;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b4090;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b4090;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b4090;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b4090;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b4090;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b4090;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b4090;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b4090;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b4090;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b4090;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b4090;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b4090;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b4090;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b4090;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b4090;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b4090;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b4090;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b4090;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b4090;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b4090;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b4090;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b4090;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b4090;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b4090;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b4090;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b4090;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b4090;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b4090;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b4090;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b4090;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b4090;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b4090;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b4090;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b4090;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b4090;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b0722;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0722;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0722;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0722;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.8785455808768478 +ACONTb;b0722;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.8785455808768476 +ACt2r;b0722;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0722;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.7628882410545845 +AKGDH;b0722;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0722;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0722;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0722;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0722;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;56.18179161383702 +Biomass_Ecoli_core;b0722;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8142975075325308 +CO2t;b0722;;co2_e <=> co2_c;-22.809833310205086;-25.347162418199428 +CS;b0722;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.8785455808768476 +CYTBD;b0722;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;48.81150613948211 +D_LACt2;b0722;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0722;;2pg_c <=> h2o_c + pep_c;14.716139568742859;8.99326453269077 +ETOHt2r;b0722;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0722;;ac_e --> ;0.0;0.0 +EX_acald_e;b0722;;acald_e --> ;0.0;0.0 +EX_akg_e;b0722;;akg_e --> ;0.0;0.0 +EX_co2_e;b0722;;co2_e <=> ;22.809833310205086;25.347162418199428 +EX_etoh_e;b0722;;etoh_e --> ;0.0;0.0 +EX_for_e;b0722;;for_e --> ;0.0;0.0 +EX_fru_e;b0722;;fru_e --> ;0.0;0.0 +EX_fum_e;b0722;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0722;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0722;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0722;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0722;;h_e <=> ;17.530865429786523;16.33480800110251 +EX_h2o_e;b0722;;h2o_e <=> ;29.175827135565836;31.278831182069357 +EX_lac__D_e;b0722;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0722;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0722;;nh4_e <=> ;-4.765319193197444;-4.440201449073384 +EX_o2_e;b0722;;o2_e <=> ;-21.799492655998886;-24.405753069741053 +EX_pi_e;b0722;;pi_e <=> ;-3.214895047684769;-2.995556240959951 +EX_pyr_e;b0722;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0722;;succ_e --> ;0.0;4.817011613443951e-16 +FBA;b0722;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;1.5661189374905506 +FBP;b0722;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0722;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0722;;for_c --> for_e;0.0;0.0 +FRD7;b0722;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0722;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0722;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-1.27013828756454e-16 +FUMt2_2;b0722;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0722;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;22.871697995300533 +GAPD;b0722;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;10.211453603959436 +GLCpts;b0722;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0722;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20821587267606811 +GLNabc;b0722;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0722;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.2319855763973155 +GLUN;b0722;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0722;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0722;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0722;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;22.87169799530053 +H2Ot;b0722;;h2o_e <=> h2o_c;-29.175827135565836;-31.278831182069357 +ICDHyr;b0722;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8785455808768485 +ICL;b0722;;icit_c --> glx_c + succ_c;0.0;-7.828259775158612e-16 +LDH_D;b0722;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0722;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0722;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0722;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-9.098398062723151e-16 +ME1;b0722;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0722;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0722;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;48.811506139482105 +NADTRHD;b0722;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;31.781369496697533 +NH4t;b0722;;nh4_e <=> nh4_c;4.765319193197444;4.440201449073384 +O2t;b0722;;o2_e <=> o2_c;21.799492655998886;24.405753069741053 +PDH;b0722;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.9303697796072634 +PFK;b0722;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;1.5661189374905509 +PFL;b0722;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0722;;g6p_c <=> f6p_c;4.860861146496871;-13.038628984344705 +PGK;b0722;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-10.211453603959438 +PGL;b0722;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;22.871697995300533 +PGM;b0722;;2pg_c <=> 3pg_c;-14.716139568742859;-8.99326453269077 +PIt2r;b0722;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.995556240959951 +PPC;b0722;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.333450937585213 +PPCK;b0722;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0722;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.7628882410545845 +PTAr;b0722;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0722;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b0722;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0722;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;14.662481615119301 +RPI;b0722;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-8.209216380181228 +SUCCt2_2;b0722;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0722;;h_e + succ_c --> h_c + succ_e;0.0;4.817011613443951e-16 +SUCDi;b0722;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b0722;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-1.137513310103802e-15 +TALA;b0722;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;7.478221507669273 +THD2;b0722;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0722;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;7.4782215076692715 +TKT2;b0722;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;7.18426010745003 +TPI;b0722;;dhap_c <=> g3p_c;7.477381962160304;1.5661189374905506 +ACALD;b0724;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0724;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0724;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0724;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.8785455808768463 +ACONTb;b0724;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.8785455808768463 +ACt2r;b0724;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0724;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.762888241054585 +AKGDH;b0724;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0724;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0724;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0724;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0724;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;56.18179161383699 +Biomass_Ecoli_core;b0724;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8142975075325308 +CO2t;b0724;;co2_e <=> co2_c;-22.809833310205086;-25.347162418199396 +CS;b0724;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.8785455808768461 +CYTBD;b0724;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;48.81150613948208 +D_LACt2;b0724;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0724;;2pg_c <=> h2o_c + pep_c;14.716139568742859;8.993264532690771 +ETOHt2r;b0724;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0724;;ac_e --> ;0.0;0.0 +EX_acald_e;b0724;;acald_e --> ;0.0;0.0 +EX_akg_e;b0724;;akg_e --> ;0.0;0.0 +EX_co2_e;b0724;;co2_e <=> ;22.809833310205086;25.347162418199396 +EX_etoh_e;b0724;;etoh_e --> ;0.0;0.0 +EX_for_e;b0724;;for_e --> ;0.0;0.0 +EX_fru_e;b0724;;fru_e --> ;0.0;0.0 +EX_fum_e;b0724;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0724;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0724;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0724;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0724;;h_e <=> ;17.530865429786523;16.334808001102488 +EX_h2o_e;b0724;;h2o_e <=> ;29.175827135565836;31.278831182069318 +EX_lac__D_e;b0724;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0724;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0724;;nh4_e <=> ;-4.765319193197444;-4.440201449073384 +EX_o2_e;b0724;;o2_e <=> ;-21.799492655998886;-24.405753069741035 +EX_pi_e;b0724;;pi_e <=> ;-3.214895047684769;-2.995556240959898 +EX_pyr_e;b0724;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0724;;succ_e --> ;0.0;0.0 +FBA;b0724;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;1.566118937490555 +FBP;b0724;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0724;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0724;;for_c --> for_e;0.0;0.0 +FRD7;b0724;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0724;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0724;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b0724;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0724;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;22.87169799530051 +GAPD;b0724;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;10.21145360395944 +GLCpts;b0724;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0724;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20821587267606811 +GLNabc;b0724;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0724;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.2319855763973155 +GLUN;b0724;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0724;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0724;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0724;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;22.871697995300508 +H2Ot;b0724;;h2o_e <=> h2o_c;-29.175827135565836;-31.278831182069318 +ICDHyr;b0724;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8785455808768463 +ICL;b0724;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0724;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0724;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0724;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0724;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b0724;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0724;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0724;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;48.81150613948207 +NADTRHD;b0724;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;31.781369496697486 +NH4t;b0724;;nh4_e <=> nh4_c;4.765319193197444;4.440201449073384 +O2t;b0724;;o2_e <=> o2_c;21.799492655998886;24.405753069741035 +PDH;b0724;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.930369779607262 +PFK;b0724;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;1.5661189374905553 +PFL;b0724;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0724;;g6p_c <=> f6p_c;4.860861146496871;-13.038628984344676 +PGK;b0724;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-10.21145360395944 +PGL;b0724;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;22.87169799530051 +PGM;b0724;;2pg_c <=> 3pg_c;-14.716139568742859;-8.993264532690771 +PIt2r;b0724;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.995556240959898 +PPC;b0724;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.333450937585219 +PPCK;b0724;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0724;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.762888241054585 +PTAr;b0724;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0724;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b0724;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0724;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;14.662481615119287 +RPI;b0724;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-8.209216380181223 +SUCCt2_2;b0724;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0724;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0724;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b0724;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b0724;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;7.478221507669265 +THD2;b0724;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0724;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;7.4782215076692635 +TKT2;b0724;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;7.184260107450022 +TPI;b0724;;dhap_c <=> g3p_c;7.477381962160304;1.566118937490555 +ACALD;b0721;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0721;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0721;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0721;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.8785455808768463 +ACONTb;b0721;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.8785455808768463 +ACt2r;b0721;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0721;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.762888241054585 +AKGDH;b0721;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0721;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0721;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0721;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0721;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;56.18179161383699 +Biomass_Ecoli_core;b0721;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8142975075325308 +CO2t;b0721;;co2_e <=> co2_c;-22.809833310205086;-25.347162418199396 +CS;b0721;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.8785455808768461 +CYTBD;b0721;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;48.81150613948208 +D_LACt2;b0721;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0721;;2pg_c <=> h2o_c + pep_c;14.716139568742859;8.993264532690771 +ETOHt2r;b0721;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0721;;ac_e --> ;0.0;0.0 +EX_acald_e;b0721;;acald_e --> ;0.0;0.0 +EX_akg_e;b0721;;akg_e --> ;0.0;0.0 +EX_co2_e;b0721;;co2_e <=> ;22.809833310205086;25.347162418199396 +EX_etoh_e;b0721;;etoh_e --> ;0.0;0.0 +EX_for_e;b0721;;for_e --> ;0.0;0.0 +EX_fru_e;b0721;;fru_e --> ;0.0;0.0 +EX_fum_e;b0721;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0721;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0721;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0721;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0721;;h_e <=> ;17.530865429786523;16.334808001102488 +EX_h2o_e;b0721;;h2o_e <=> ;29.175827135565836;31.278831182069318 +EX_lac__D_e;b0721;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0721;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0721;;nh4_e <=> ;-4.765319193197444;-4.440201449073384 +EX_o2_e;b0721;;o2_e <=> ;-21.799492655998886;-24.405753069741035 +EX_pi_e;b0721;;pi_e <=> ;-3.214895047684769;-2.995556240959898 +EX_pyr_e;b0721;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0721;;succ_e --> ;0.0;0.0 +FBA;b0721;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;1.566118937490555 +FBP;b0721;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0721;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0721;;for_c --> for_e;0.0;0.0 +FRD7;b0721;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0721;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0721;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b0721;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0721;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;22.87169799530051 +GAPD;b0721;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;10.21145360395944 +GLCpts;b0721;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0721;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20821587267606811 +GLNabc;b0721;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0721;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.2319855763973155 +GLUN;b0721;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0721;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0721;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0721;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;22.871697995300508 +H2Ot;b0721;;h2o_e <=> h2o_c;-29.175827135565836;-31.278831182069318 +ICDHyr;b0721;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8785455808768463 +ICL;b0721;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0721;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0721;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0721;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0721;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b0721;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0721;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0721;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;48.81150613948207 +NADTRHD;b0721;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;31.781369496697486 +NH4t;b0721;;nh4_e <=> nh4_c;4.765319193197444;4.440201449073384 +O2t;b0721;;o2_e <=> o2_c;21.799492655998886;24.405753069741035 +PDH;b0721;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.930369779607262 +PFK;b0721;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;1.5661189374905553 +PFL;b0721;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0721;;g6p_c <=> f6p_c;4.860861146496871;-13.038628984344676 +PGK;b0721;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-10.21145360395944 +PGL;b0721;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;22.87169799530051 +PGM;b0721;;2pg_c <=> 3pg_c;-14.716139568742859;-8.993264532690771 +PIt2r;b0721;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.995556240959898 +PPC;b0721;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.333450937585219 +PPCK;b0721;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0721;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.762888241054585 +PTAr;b0721;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0721;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b0721;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0721;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;14.662481615119287 +RPI;b0721;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-8.209216380181223 +SUCCt2_2;b0721;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0721;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0721;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b0721;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b0721;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;7.478221507669265 +THD2;b0721;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0721;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;7.4782215076692635 +TKT2;b0721;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;7.184260107450022 +TPI;b0721;;dhap_c <=> g3p_c;7.477381962160304;1.566118937490555 +ACALD;b0723;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0723;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0723;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0723;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.8785455808768463 +ACONTb;b0723;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.8785455808768463 +ACt2r;b0723;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0723;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.762888241054585 +AKGDH;b0723;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0723;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0723;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0723;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0723;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;56.18179161383699 +Biomass_Ecoli_core;b0723;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8142975075325308 +CO2t;b0723;;co2_e <=> co2_c;-22.809833310205086;-25.347162418199396 +CS;b0723;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.8785455808768461 +CYTBD;b0723;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;48.81150613948208 +D_LACt2;b0723;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0723;;2pg_c <=> h2o_c + pep_c;14.716139568742859;8.993264532690771 +ETOHt2r;b0723;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0723;;ac_e --> ;0.0;0.0 +EX_acald_e;b0723;;acald_e --> ;0.0;0.0 +EX_akg_e;b0723;;akg_e --> ;0.0;0.0 +EX_co2_e;b0723;;co2_e <=> ;22.809833310205086;25.347162418199396 +EX_etoh_e;b0723;;etoh_e --> ;0.0;0.0 +EX_for_e;b0723;;for_e --> ;0.0;0.0 +EX_fru_e;b0723;;fru_e --> ;0.0;0.0 +EX_fum_e;b0723;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0723;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0723;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0723;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0723;;h_e <=> ;17.530865429786523;16.334808001102488 +EX_h2o_e;b0723;;h2o_e <=> ;29.175827135565836;31.278831182069318 +EX_lac__D_e;b0723;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0723;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0723;;nh4_e <=> ;-4.765319193197444;-4.440201449073384 +EX_o2_e;b0723;;o2_e <=> ;-21.799492655998886;-24.405753069741035 +EX_pi_e;b0723;;pi_e <=> ;-3.214895047684769;-2.995556240959898 +EX_pyr_e;b0723;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0723;;succ_e --> ;0.0;0.0 +FBA;b0723;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;1.566118937490555 +FBP;b0723;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0723;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0723;;for_c --> for_e;0.0;0.0 +FRD7;b0723;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0723;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0723;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0 +FUMt2_2;b0723;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0723;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;22.87169799530051 +GAPD;b0723;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;10.21145360395944 +GLCpts;b0723;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0723;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20821587267606811 +GLNabc;b0723;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0723;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.2319855763973155 +GLUN;b0723;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0723;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0723;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0723;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;22.871697995300508 +H2Ot;b0723;;h2o_e <=> h2o_c;-29.175827135565836;-31.278831182069318 +ICDHyr;b0723;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8785455808768463 +ICL;b0723;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0723;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0723;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0723;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0723;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0 +ME1;b0723;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0723;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0723;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;48.81150613948207 +NADTRHD;b0723;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;31.781369496697486 +NH4t;b0723;;nh4_e <=> nh4_c;4.765319193197444;4.440201449073384 +O2t;b0723;;o2_e <=> o2_c;21.799492655998886;24.405753069741035 +PDH;b0723;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.930369779607262 +PFK;b0723;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;1.5661189374905553 +PFL;b0723;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0723;;g6p_c <=> f6p_c;4.860861146496871;-13.038628984344676 +PGK;b0723;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-10.21145360395944 +PGL;b0723;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;22.87169799530051 +PGM;b0723;;2pg_c <=> 3pg_c;-14.716139568742859;-8.993264532690771 +PIt2r;b0723;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.995556240959898 +PPC;b0723;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.333450937585219 +PPCK;b0723;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0723;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.762888241054585 +PTAr;b0723;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0723;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b0723;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0723;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;14.662481615119287 +RPI;b0723;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-8.209216380181223 +SUCCt2_2;b0723;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0723;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0723;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0 +SUCOAS;b0723;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b0723;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;7.478221507669265 +THD2;b0723;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0723;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;7.4782215076692635 +TKT2;b0723;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;7.184260107450022 +TPI;b0723;;dhap_c <=> g3p_c;7.477381962160304;1.566118937490555 +ACALD;b0728;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0728;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0728;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0728;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.836807622090758 +ACONTb;b0728;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.836807622090757 +ACt2r;b0728;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0728;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0728;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0728;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0728;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0728;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0728;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.42816442230028 +Biomass_Ecoli_core;b0728;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8583074080226886 +CO2t;b0728;;co2_e <=> co2_c;-22.809833310205086;-23.474299097890484 +CS;b0728;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.836807622090757 +CYTBD;b0728;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.96401980695093 +D_LACt2;b0728;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0728;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.390098435259256 +ETOHt2r;b0728;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0728;;ac_e --> ;0.0;0.0 +EX_acald_e;b0728;;acald_e --> ;0.0;0.0 +EX_akg_e;b0728;;akg_e --> ;0.0;0.0 +EX_co2_e;b0728;;co2_e <=> ;22.809833310205086;23.474299097890484 +EX_etoh_e;b0728;;etoh_e --> ;0.0;0.0 +EX_for_e;b0728;;for_e --> ;0.0;0.0 +EX_fru_e;b0728;;fru_e --> ;0.0;0.0 +EX_fum_e;b0728;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0728;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0728;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0728;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0728;;h_e <=> ;17.530865429786523;17.217646604935172 +EX_h2o_e;b0728;;h2o_e <=> ;29.175827135565836;29.726553580890982 +EX_lac__D_e;b0728;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0728;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0728;;nh4_e <=> ;-4.765319193197444;-4.680178634466116 +EX_o2_e;b0728;;o2_e <=> ;-21.799492655998886;-22.48200990347546 +EX_pi_e;b0728;;pi_e <=> ;-3.214895047684769;-3.157455461893053 +EX_pyr_e;b0728;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0728;;succ_e --> ;0.0;0.0 +FBA;b0728;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.102006521647742 +FBP;b0728;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0728;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0728;;for_c --> for_e;0.0;0.0 +FRD7;b0728;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0728;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0728;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.910779759575082 +FUMt2_2;b0728;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0728;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.132705298776274 +GAPD;b0728;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.674126317661198 +GLCpts;b0728;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0728;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21946920423140145 +GLNabc;b0728;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0728;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.460709430234714 +GLUN;b0728;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0728;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0728;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0728;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.132705298776272 +H2Ot;b0728;;h2o_e <=> h2o_c;-29.175827135565836;-29.726553580890982 +ICDHyr;b0728;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9260278625156759 +ICL;b0728;;icit_c --> glx_c + succ_c;0.0;4.910779759575082 +LDH_D;b0728;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0728;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;4.910779759575082 +MALt2_2;b0728;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0728;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.3703454680048965 +ME1;b0728;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0728;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;2.4512140511452674 +NADH16;b0728;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.05324004737584 +NADTRHD;b0728;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0728;;nh4_e <=> nh4_c;4.765319193197444;4.680178634466116 +O2t;b0728;;o2_e <=> o2_c;21.799492655998886;22.48200990347546 +PDH;b0728;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;13.964351885453269 +PFK;b0728;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.102006521647743 +PFL;b0728;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0728;;g6p_c <=> f6p_c;4.860861146496871;3.6913416825790764 +PGK;b0728;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.674126317661202 +PGL;b0728;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.132705298776274 +PGM;b0728;;2pg_c <=> 3pg_c;-14.716139568742859;-14.390098435259256 +PIt2r;b0728;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.157455461893053 +PPC;b0728;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0 +PPCK;b0728;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0728;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0728;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0728;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.9445510597546725 +PYRt2;b0728;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0728;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.471518834297473 +RPI;b0728;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.6611864644787997 +SUCCt2_2;b0728;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0728;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0728;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.910779759575082 +SUCOAS;b0728;;atp_c + coa_c + succ_c --> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b0728;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.890683904296832 +THD2;b0728;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0728;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.8906839042968318 +TKT2;b0728;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.5808349300006415 +TPI;b0728;;dhap_c <=> g3p_c;7.477381962160304;7.102006521647742 +ACALD;b0729;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0729;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0729;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0729;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.836807622090764 +ACONTb;b0729;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.836807622090764 +ACt2r;b0729;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0729;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0729;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b0729;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0729;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0729;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0729;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.42816442230032 +Biomass_Ecoli_core;b0729;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.858307408022689 +CO2t;b0729;;co2_e <=> co2_c;-22.809833310205086;-23.4742990978905 +CS;b0729;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.836807622090764 +CYTBD;b0729;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.964019806950944 +D_LACt2;b0729;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0729;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.390098435259251 +ETOHt2r;b0729;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0729;;ac_e --> ;0.0;0.0 +EX_acald_e;b0729;;acald_e --> ;0.0;0.0 +EX_akg_e;b0729;;akg_e --> ;0.0;0.0 +EX_co2_e;b0729;;co2_e <=> ;22.809833310205086;23.4742990978905 +EX_etoh_e;b0729;;etoh_e --> ;0.0;0.0 +EX_for_e;b0729;;for_e --> ;0.0;0.0 +EX_fru_e;b0729;;fru_e --> ;0.0;0.0 +EX_fum_e;b0729;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0729;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0729;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0729;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0729;;h_e <=> ;17.530865429786523;17.217646604935073 +EX_h2o_e;b0729;;h2o_e <=> ;29.175827135565836;29.726553580890982 +EX_lac__D_e;b0729;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0729;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0729;;nh4_e <=> ;-4.765319193197444;-4.680178634466118 +EX_o2_e;b0729;;o2_e <=> ;-21.799492655998886;-22.48200990347547 +EX_pi_e;b0729;;pi_e <=> ;-3.214895047684769;-3.1574554618930946 +EX_pyr_e;b0729;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0729;;succ_e --> ;0.0;0.0 +FBA;b0729;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.1020065216477395 +FBP;b0729;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0729;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0729;;for_c --> for_e;0.0;0.0 +FRD7;b0729;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0729;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0729;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.910779759575085 +FUMt2_2;b0729;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0729;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.132705298776282 +GAPD;b0729;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.674126317661196 +GLCpts;b0729;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0729;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21946920423140157 +GLNabc;b0729;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0729;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.460709430234716 +GLUN;b0729;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0729;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0729;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0729;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.132705298776281 +H2Ot;b0729;;h2o_e <=> h2o_c;-29.175827135565836;-29.726553580890982 +ICDHyr;b0729;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9260278625156771 +ICL;b0729;;icit_c --> glx_c + succ_c;0.0;4.910779759575085 +LDH_D;b0729;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0729;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;4.910779759575085 +MALt2_2;b0729;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0729;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.370345468004903 +ME1;b0729;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0729;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;2.4512140511452674 +NADH16;b0729;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.05324004737586 +NADTRHD;b0729;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0729;;nh4_e <=> nh4_c;4.765319193197444;4.680178634466118 +O2t;b0729;;o2_e <=> o2_c;21.799492655998886;22.48200990347547 +PDH;b0729;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;13.964351885453283 +PFK;b0729;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.1020065216477395 +PFL;b0729;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0729;;g6p_c <=> f6p_c;4.860861146496871;3.6913416825790697 +PGK;b0729;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.674126317661198 +PGL;b0729;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.1327052987762825 +PGM;b0729;;2pg_c <=> 3pg_c;-14.716139568742859;-14.390098435259251 +PIt2r;b0729;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1574554618930946 +PPC;b0729;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0 +PPCK;b0729;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0729;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0729;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0729;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.9445510597546733 +PYRt2;b0729;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0729;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.4715188342974783 +RPI;b0729;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.6611864644788032 +SUCCt2_2;b0729;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0729;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0729;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.910779759575085 +SUCOAS;b0729;;atp_c + coa_c + succ_c --> adp_c + pi_c + succoa_c;-5.064375661482159;0.0 +TALA;b0729;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.8906839042968346 +THD2;b0729;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0729;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.8906839042968344 +TKT2;b0729;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.580834930000644 +TPI;b0729;;dhap_c <=> g3p_c;7.477381962160304;7.1020065216477395 +ACALD;b2464;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2464;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2464;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2464;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2464;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350337 +ACt2r;b2464;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2464;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2464;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.0643756614821 +AKGt2r;b2464;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2464;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2464;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2464;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451749 +Biomass_Ecoli_core;b2464;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2464;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204986 +CS;b2464;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350336 +CYTBD;b2464;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199756 +D_LACt2;b2464;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2464;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283 +ETOHt2r;b2464;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2464;;ac_e --> ;0.0;0.0 +EX_acald_e;b2464;;acald_e --> ;0.0;0.0 +EX_akg_e;b2464;;akg_e --> ;0.0;0.0 +EX_co2_e;b2464;;co2_e <=> ;22.809833310205086;22.809833310204986 +EX_etoh_e;b2464;;etoh_e --> ;0.0;0.0 +EX_for_e;b2464;;for_e --> ;0.0;0.0 +EX_fru_e;b2464;;fru_e --> ;0.0;0.0 +EX_fum_e;b2464;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2464;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2464;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2464;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2464;;h_e <=> ;17.530865429786523;17.530865429786658 +EX_h2o_e;b2464;;h2o_e <=> ;29.175827135565836;29.175827135565864 +EX_lac__D_e;b2464;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2464;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2464;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2464;;o2_e <=> ;-21.799492655998886;-21.799492655998773 +EX_pi_e;b2464;;pi_e <=> ;-3.214895047684769;-3.214895047684795 +EX_pyr_e;b2464;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2464;;succ_e --> ;0.0;0.0 +FBA;b2464;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160283 +FBP;b2464;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2464;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2464;;for_c --> for_e;0.0;0.0 +FRD7;b2464;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2464;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2464;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482101 +FUMt2_2;b2464;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2464;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.95998494457466 +GAPD;b2464;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604 +GLCpts;b2464;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2464;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2464;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2464;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2464;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2464;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2464;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2464;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574659 +H2Ot;b2464;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565864 +ICDHyr;b2464;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.0072495753503405 +ICL;b2464;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2464;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2464;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2464;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2464;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482099 +ME1;b2464;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2464;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2464;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051545 +NADTRHD;b2464;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2464;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2464;;o2_e <=> o2_c;21.799492655998886;21.799492655998773 +PDH;b2464;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2464;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160284 +PFL;b2464;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2464;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496814 +PGK;b2464;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608 +PGL;b2464;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574659 +PGM;b2464;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283 +PIt2r;b2464;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684795 +PPC;b2464;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368732 +PPCK;b2464;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2464;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2464;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2464;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067863 +PYRt2;b2464;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2464;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507531 +RPI;b2464;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671277 +SUCCt2_2;b2464;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2464;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2464;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482101 +SUCOAS;b2464;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482101 +TALA;b2464;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615674 +THD2;b2464;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2464;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615672 +TKT2;b2464;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245964 +TPI;b2464;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160283 +ACALD;b0008;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b0008;;acald_e <=> acald_c;0.0;0.0 +ACKr;b0008;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b0008;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b0008;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b0008;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b0008;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b0008;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b0008;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b0008;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b0008;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b0008;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b0008;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b0008;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b0008;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b0008;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b0008;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b0008;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b0008;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b0008;;ac_e --> ;0.0;0.0 +EX_acald_e;b0008;;acald_e --> ;0.0;0.0 +EX_akg_e;b0008;;akg_e --> ;0.0;0.0 +EX_co2_e;b0008;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b0008;;etoh_e --> ;0.0;0.0 +EX_for_e;b0008;;for_e --> ;0.0;0.0 +EX_fru_e;b0008;;fru_e --> ;0.0;0.0 +EX_fum_e;b0008;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b0008;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b0008;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b0008;;glu__L_e --> ;0.0;0.0 +EX_h_e;b0008;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b0008;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b0008;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b0008;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b0008;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b0008;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b0008;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b0008;;pyr_e --> ;0.0;0.0 +EX_succ_e;b0008;;succ_e --> ;0.0;0.0 +FBA;b0008;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b0008;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b0008;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b0008;;for_c --> for_e;0.0;0.0 +FRD7;b0008;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b0008;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b0008;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b0008;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b0008;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b0008;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b0008;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b0008;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b0008;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b0008;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b0008;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b0008;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b0008;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b0008;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b0008;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b0008;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b0008;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b0008;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b0008;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b0008;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b0008;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b0008;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b0008;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b0008;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b0008;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b0008;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b0008;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b0008;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b0008;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b0008;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b0008;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b0008;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b0008;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b0008;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b0008;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b0008;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b0008;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b0008;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b0008;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b0008;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b0008;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b0008;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b0008;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b0008;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b0008;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b0008;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b0008;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b0008;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b0008;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b0008;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b0008;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b0008;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2935;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2935;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2935;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2935;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2935;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2935;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2935;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2935;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2935;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2935;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2935;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2935;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2935;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2935;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2935;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2935;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2935;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2935;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2935;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2935;;ac_e --> ;0.0;0.0 +EX_acald_e;b2935;;acald_e --> ;0.0;0.0 +EX_akg_e;b2935;;akg_e --> ;0.0;0.0 +EX_co2_e;b2935;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2935;;etoh_e --> ;0.0;0.0 +EX_for_e;b2935;;for_e --> ;0.0;0.0 +EX_fru_e;b2935;;fru_e --> ;0.0;0.0 +EX_fum_e;b2935;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2935;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2935;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2935;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2935;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2935;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2935;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2935;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2935;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2935;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2935;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2935;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2935;;succ_e --> ;0.0;0.0 +FBA;b2935;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2935;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2935;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2935;;for_c --> for_e;0.0;0.0 +FRD7;b2935;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2935;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2935;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2935;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2935;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2935;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2935;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2935;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2935;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2935;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2935;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2935;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2935;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2935;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2935;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2935;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2935;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2935;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2935;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2935;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2935;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2935;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2935;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2935;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2935;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2935;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2935;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2935;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2935;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2935;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2935;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2935;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2935;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2935;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2935;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2935;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2935;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2935;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2935;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2935;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2935;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2935;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2935;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2935;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2935;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2935;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2935;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2935;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2935;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2935;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2935;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2935;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b2465;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b2465;;acald_e <=> acald_c;0.0;0.0 +ACKr;b2465;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b2465;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337 +ACONTb;b2465;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338 +ACt2r;b2465;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b2465;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0 +AKGDH;b2465;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093 +AKGt2r;b2465;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b2465;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b2465;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39 +ATPS4r;b2465;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476 +Biomass_Ecoli_core;b2465;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305 +CO2t;b2465;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497 +CS;b2465;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337 +CYTBD;b2465;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753 +D_LACt2;b2465;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b2465;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836 +ETOHt2r;b2465;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b2465;;ac_e --> ;0.0;0.0 +EX_acald_e;b2465;;acald_e --> ;0.0;0.0 +EX_akg_e;b2465;;akg_e --> ;0.0;0.0 +EX_co2_e;b2465;;co2_e <=> ;22.809833310205086;22.80983331020497 +EX_etoh_e;b2465;;etoh_e --> ;0.0;0.0 +EX_for_e;b2465;;for_e --> ;0.0;0.0 +EX_fru_e;b2465;;fru_e --> ;0.0;0.0 +EX_fum_e;b2465;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b2465;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b2465;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b2465;;glu__L_e --> ;0.0;0.0 +EX_h_e;b2465;;h_e <=> ;17.530865429786523;17.530865429786648 +EX_h2o_e;b2465;;h2o_e <=> ;29.175827135565836;29.175827135565832 +EX_lac__D_e;b2465;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b2465;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b2465;;nh4_e <=> ;-4.765319193197444;-4.765319193197457 +EX_o2_e;b2465;;o2_e <=> ;-21.799492655998886;-21.799492655998762 +EX_pi_e;b2465;;pi_e <=> ;-3.214895047684769;-3.214895047684796 +EX_pyr_e;b2465;;pyr_e --> ;0.0;0.0 +EX_succ_e;b2465;;succ_e --> ;0.0;0.0 +FBA;b2465;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286 +FBP;b2465;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b2465;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b2465;;for_c --> for_e;0.0;0.0 +FRD7;b2465;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b2465;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b2465;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093 +FUMt2_2;b2465;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b2465;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654 +GAPD;b2465;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608 +GLCpts;b2465;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b2465;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762 +GLNabc;b2465;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b2465;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563 +GLUN;b2465;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b2465;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b2465;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b2465;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536 +H2Ot;b2465;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832 +ICDHyr;b2465;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338 +ICL;b2465;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b2465;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b2465;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b2465;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b2465;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093 +ME1;b2465;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b2465;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b2465;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435 +NADTRHD;b2465;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0 +NH4t;b2465;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458 +O2t;b2465;;o2_e <=> o2_c;21.799492655998886;21.799492655998762 +PDH;b2465;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662 +PFK;b2465;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286 +PFL;b2465;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b2465;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819 +PGK;b2465;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761 +PGL;b2465;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654 +PGM;b2465;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836 +PIt2r;b2465;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796 +PPC;b2465;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325 +PPCK;b2465;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b2465;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0 +PTAr;b2465;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b2465;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881 +PYRt2;b2465;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b2465;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527 +RPI;b2465;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264 +SUCCt2_2;b2465;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b2465;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b2465;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094 +SUCOAS;b2465;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094 +TALA;b2465;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654 +THD2;b2465;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b2465;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654 +TKT2;b2465;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962 +TPI;b2465;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286 +ACALD;b3919;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0 +ACALDt;b3919;;acald_e <=> acald_c;0.0;0.0 +ACKr;b3919;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0 +ACONTa;b3919;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.7595854630451013 +ACONTb;b3919;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.7595854630451014 +ACt2r;b3919;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0 +ADK1;b3919;;amp_c + atp_c <=> 2.0 adp_c;0.0;4.607428997873811 +AKGDH;b3919;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0 +AKGt2r;b3919;;akg_e + h_e <=> akg_c + h_c;0.0;0.0 +ALCD2x;b3919;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0 +ATPM;b3919;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;26.210749940156802 +ATPS4r;b3919;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;68.8853159013785 +Biomass_Ecoli_core;b3919;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.7040369478590248 +CO2t;b3919;;co2_e <=> co2_c;-22.809833310205086;-30.039355665385333 +CS;b3919;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.7595854630451012 +CYTBD;b3919;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;58.45083709993102 +D_LACt2;b3919;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0 +ENO;b3919;;2pg_c <=> h2o_c + pep_c;14.716139568742859;7.775524859544626 +ETOHt2r;b3919;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0 +EX_ac_e;b3919;;ac_e --> ;0.0;0.0 +EX_acald_e;b3919;;acald_e --> ;0.0;0.0 +EX_akg_e;b3919;;akg_e --> ;0.0;0.0 +EX_co2_e;b3919;;co2_e <=> ;22.809833310205086;30.039355665385333 +EX_etoh_e;b3919;;etoh_e --> ;0.0;0.0 +EX_for_e;b3919;;for_e --> ;0.0;0.0 +EX_fru_e;b3919;;fru_e --> ;0.0;0.0 +EX_fum_e;b3919;;fum_e --> ;0.0;0.0 +EX_glc__D_e;b3919;;glc__D_e <=> ;-10.0;-10.0 +EX_gln__L_e;b3919;;gln__L_e --> ;0.0;0.0 +EX_glu__L_e;b3919;;glu__L_e --> ;0.0;0.0 +EX_h_e;b3919;;h_e <=> ;17.530865429786523;14.12298117405203 +EX_h2o_e;b3919;;h2o_e <=> ;29.175827135565836;35.16784240836959 +EX_lac__D_e;b3919;;lac__D_e --> ;0.0;0.0 +EX_mal__L_e;b3919;;mal__L_e --> ;0.0;0.0 +EX_nh4_e;b3919;;nh4_e <=> ;-4.765319193197444;-3.838972669285688 +EX_o2_e;b3919;;o2_e <=> ;-21.799492655998886;-29.225418549965504 +EX_pi_e;b3919;;pi_e <=> ;-3.214895047684769;-2.5899407200890217 +EX_pyr_e;b3919;;pyr_e --> ;0.0;0.0 +EX_succ_e;b3919;;succ_e --> ;0.0;0.0 +FBA;b3919;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;0.0 +FBP;b3919;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0 +FORt2;b3919;;for_e + h_e --> for_c + h_c;0.0;0.0 +FORti;b3919;;for_c --> for_e;0.0;0.0 +FRD7;b3919;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0 +FRUpts2;b3919;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0 +FUM;b3919;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;1.8194300213456418e-15 +FUMt2_2;b3919;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0 +G6PDH2r;b3919;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;27.899083343893903 +GAPD;b3919;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;8.828764133541728 +GLCpts;b3919;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002 +GLNS;b3919;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.18002224756755264 +GLNabc;b3919;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0 +GLUDy;b3919;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-3.6589504217181372 +GLUN;b3919;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0 +GLUSy;b3919;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0 +GLUt2r;b3919;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0 +GND;b3919;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;27.8990833438939 +H2Ot;b3919;;h2o_e <=> h2o_c;-29.175827135565836;-35.16784240836959 +ICDHyr;b3919;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.7595854630451014 +ICL;b3919;;icit_c --> glx_c + succ_c;0.0;0.0 +LDH_D;b3919;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0 +MALS;b3919;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0 +MALt2_2;b3919;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0 +MDH;b3919;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;1.8194300213456418e-15 +ME1;b3919;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0 +ME2;b3919;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0 +NADH16;b3919;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;58.450837099931015 +NADTRHD;b3919;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;43.72667877610217 +NH4t;b3919;;nh4_e <=> nh4_c;4.765319193197444;3.8389726692856874 +O2t;b3919;;o2_e <=> o2_c;21.799492655998886;29.225418549965504 +PDH;b3919;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.3981751362311448 +PFK;b3919;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;-3.3456810303021106e-15 +PFL;b3919;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0 +PGI;b3919;;g6p_c <=> f6p_c;4.860861146496871;-18.043410918204998 +PGK;b3919;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-8.828764133541728 +PGL;b3919;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;27.899083343893903 +PGM;b3919;;2pg_c <=> 3pg_c;-14.716139568742859;-7.775524859544626 +PIt2r;b3919;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.5899407200890217 +PPC;b3919;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.017488277784812 +PPCK;b3919;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0 +PPS;b3919;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;4.60742899787381 +PTAr;b3919;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0 +PYK;b3919;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0 +PYRt2;b3919;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0 +RPE;b3919;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;18.0933271378082 +RPI;b3919;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-9.8057562060857 +SUCCt2_2;b3919;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0 +SUCCt3;b3919;;h_e + succ_c --> h_c + succ_e;0.0;0.0 +SUCDi;b3919;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;1.819430021345642e-15 +SUCOAS;b3919;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.68756655051901e-15 +TALA;b3919;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;9.173742237992654 +THD2;b3919;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0 +TKT1;b3919;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;9.173742237992654 +TKT2;b3919;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;8.919584899815547 +TPI;b3919;;dhap_c --> g3p_c;7.477381962160304;0.0
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/invalid_format.txt Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,1 @@ +This is just a junk file for testing. \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/textbook_model_cobrapy.xml Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,5467 @@ +<?xml version="1.0" encoding="UTF-8"?> +<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" xmlns:fbc="http://www.sbml.org/sbml/level3/version1/fbc/version2" metaid="meta_" sboTerm="SBO:0000624" level="3" version="1" fbc:required="false"> + <model metaid="meta_e_coli_core" id="e_coli_core" fbc:strict="true"> + <listOfUnitDefinitions> + <unitDefinition id="mmol_per_gDW_per_hr"> + <listOfUnits> + <unit kind="mole" exponent="1" scale="-3" multiplier="1"/> + <unit kind="gram" exponent="-1" scale="0" multiplier="1"/> + <unit kind="second" exponent="-1" scale="0" multiplier="3600"/> + </listOfUnits> + </unitDefinition> + </listOfUnitDefinitions> + <listOfCompartments> + <compartment id="c" name="cytosol" constant="true"/> + <compartment id="e" name="extracellular" constant="true"/> + </listOfCompartments> + <listOfSpecies> + <species metaid="meta_M_13dpg_c" id="M_13dpg_c" name="3-Phospho-D-glyceroyl phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C3H4O10P2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_13dpg_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/13dpg"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/DPG"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16001"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:1658"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:20189"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57604"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11881"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01270"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00236"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3535"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29800"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00203"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00236"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_2pg_c" id="M_2pg_c" name="D-Glycerate 2-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C3H4O7P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_2pg_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/2pg"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/2-PG"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:1267"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:58289"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17835"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:21028"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11651"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12986"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24344"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:39868"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB03391"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00362"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00631"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3904"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_30485"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00482"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00631"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_3pg_c" id="M_3pg_c" name="3-Phospho-D-glycerate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C3H4O7P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_3pg_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/3pg"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/G3P"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40016"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:58272"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57998"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11879"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:1657"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:1659"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17050"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:21029"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11882"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11880"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12987"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17794"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24345"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00807"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00197"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00597"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3497"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29728"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00169"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00597"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00197"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_6pgc_c" id="M_6pgc_c" name="6-Phospho-D-gluconate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C6H10O10P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_6pgc_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/6pgc"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CPD-2961"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2231"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12232"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:48928"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16863"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:58759"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40282"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:33851"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01316"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00345"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3638"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29996"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00284"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00345"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_6pgl_c" id="M_6pgl_c" name="6-phospho-D-glucono-1,5-lactone" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C6H9O9P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_6pgl_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/6pgl"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/D-6-P-GLUCONO-DELTA-LACTONE"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16938"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12233"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4160"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:20989"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57955"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12958"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01127"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01236"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/4457"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_31467"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00911"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC01236"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_ac_c" id="M_ac_c" name="Acetate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C2H3O2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_ac_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/ac"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ACET"/> + <rdf:li rdf:resource="https://identifiers.org/cas/71-50-1"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:62947"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:62964"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32029"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22165"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:3310"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2387"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:62984"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63879"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32138"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15366"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13704"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63078"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30089"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40480"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22169"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40486"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:59199"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63045"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32954"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00042"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00033"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00010"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01010000"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01010002"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3335"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113539"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2022890"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29416"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1524044"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_390305"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00029"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00033"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_ac_e" id="M_ac_e" name="Acetate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C2H3O2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_ac_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/ac"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ACET"/> + <rdf:li rdf:resource="https://identifiers.org/cas/71-50-1"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:62947"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:62964"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32029"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22165"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:3310"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2387"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:62984"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63879"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32138"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15366"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13704"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63078"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30089"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40480"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22169"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40486"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:59199"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63045"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32954"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00042"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00033"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00010"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01010000"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01010002"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3335"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113539"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2022890"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29416"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1524044"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_390305"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00029"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00033"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_acald_c" id="M_acald_c" name="Acetaldehyde" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2H4O"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_acald_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/acald"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ACETALD"/> + <rdf:li rdf:resource="https://identifiers.org/cas/75-07-0"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13703"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2383"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15343"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22158"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40533"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00990"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00084"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3384"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113532"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29510"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113681"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113745"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00071"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00084"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_acald_e" id="M_acald_e" name="Acetaldehyde" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2H4O"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_acald_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/acald"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ACETALD"/> + <rdf:li rdf:resource="https://identifiers.org/cas/75-07-0"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13703"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2383"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15343"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22158"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40533"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00990"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00084"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3384"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113532"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29510"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113681"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113745"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00071"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00084"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_accoa_c" id="M_accoa_c" name="Acetyl-CoA" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C23H34N7O17P3S"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_accoa_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/accoa"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ACETYL-COA"/> + <rdf:li rdf:resource="https://identifiers.org/cas/72-89-9"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13712"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22192"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40470"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2408"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57288"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15351"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01206"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00024"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050029"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050000"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3326"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113559"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_727753"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113560"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_353123"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_76183"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00022"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00024"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_acon_C_c" id="M_acon_C_c" name="cis-Aconitate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C6H3O6"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_acon_C_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/acon_C"/> + <rdf:li rdf:resource="https://identifiers.org/cas/585-84-2"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00417"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3707"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_actp_c" id="M_actp_c" name="Acetyl phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C2H3O5P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_actp_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/actp"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ACETYL-P"/> + <rdf:li rdf:resource="https://identifiers.org/cas/19926-71-7"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13711"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2407"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22191"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:46262"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15350"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01494"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00227"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3527"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00196"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00227"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_adp_c" id="M_adp_c" name="ADP" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C10H12N5O10P2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_adp_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/adp"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ADP"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ADP-GROUP"/> + <rdf:li rdf:resource="https://identifiers.org/cas/58-64-0"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13222"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16761"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2342"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22244"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40553"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:456216"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01341"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00008"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.glycan/G11113"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3310"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_190072"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_481002"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_211606"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_429160"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29370"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_196180"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113581"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113582"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_114564"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_114565"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_429153"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00008"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00008"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_akg_c" id="M_akg_c" name="2-Oxoglutarate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C5H4O5"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_akg_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/akg"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/2-KETOGLUTARATE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/328-50-7"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30915"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40661"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:1253"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:19749"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:19748"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16810"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30916"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11638"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB02812"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00208"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00026"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3328"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113594"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113671"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389537"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_561075"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29406"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1650779"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00024"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00026"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_akg_e" id="M_akg_e" name="2-Oxoglutarate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C5H4O5"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_akg_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/akg"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/2-KETOGLUTARATE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/328-50-7"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30915"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40661"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:1253"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:19749"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:19748"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16810"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30916"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:11638"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB02812"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00208"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00026"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3328"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113594"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113671"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389537"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_561075"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29406"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1650779"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00024"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00026"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_amp_c" id="M_amp_c" name="AMP" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C10H12N5O7P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_amp_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/amp"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CPD0-1139"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/AMP-GROUP"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/AMP"/> + <rdf:li rdf:resource="https://identifiers.org/cas/61-19-8"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12056"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:47222"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40726"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40826"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13740"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13235"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13234"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40786"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37096"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22245"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22242"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40510"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16027"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2356"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:456215"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13736"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00045"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00020"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D02769"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D06299"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3322"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389620"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_159448"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_164121"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_76577"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2046064"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00018"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00020"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_atp_c" id="M_atp_c" name="ATP" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C10H12N5O13P3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_atp_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/atp"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ATP"/> + <rdf:li rdf:resource="https://identifiers.org/cas/56-65-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40938"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15422"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57299"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13236"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10789"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30616"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22249"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10841"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:2359"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00538"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00002"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D08646"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3304"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_190078"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113592"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113593"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_114570"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29358"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389573"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_139836"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_211579"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00002"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00002"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_cit_c" id="M_cit_c" name="Citrate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C6H5O7"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_cit_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/cit"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CIT"/> + <rdf:li rdf:resource="https://identifiers.org/cas/77-92-9"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:53258"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23322"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:50744"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23321"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:35810"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:3727"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32142"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30769"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63037"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63076"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:41523"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:35806"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:35802"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:35809"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16947"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13999"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42563"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00094"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00158"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C13660"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C12649"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D07525"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00037"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D01222"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D07691"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3458"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_76190"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_433138"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29654"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00137"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd09279"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00158"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_co2_c" id="M_co2_c" name="CO2" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="CO2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_co2_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/co2"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CARBON-DIOXIDE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/124-38-9"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:48829"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16526"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13284"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13285"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13282"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13283"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23011"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:3283"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01967"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00011"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00004"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3313"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_159751"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_159942"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1237009"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29376"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113528"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389536"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_189480"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00011"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00011"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_co2_e" id="M_co2_e" name="CO2" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="CO2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_co2_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/co2"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CARBON-DIOXIDE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/124-38-9"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:48829"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16526"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13284"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13285"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13282"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13283"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23011"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:3283"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01967"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00011"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00004"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3313"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_159751"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_159942"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1237009"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29376"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113528"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389536"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_189480"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00011"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00011"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_coa_c" id="M_coa_c" name="Coenzyme A" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C21H32N7O16P3S"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_coa_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/coa"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CO-A"/> + <rdf:li rdf:resource="https://identifiers.org/cas/85-61-0"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57287"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13295"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13294"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13298"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:41631"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:41597"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:741566"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15346"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23355"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:3771"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01423"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00010"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3312"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_76194"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_193514"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29374"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2485002"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_162743"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00010"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00010"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_dhap_c" id="M_dhap_c" name="Dihydroxyacetone phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C3H5O6P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_dhap_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/dhap"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/DIHYDROXY-ACETONE-PHOSPHATE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/57-04-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14341"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57642"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14342"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16108"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5454"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24355"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:39571"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01473"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB11735"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00111"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3411"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_188451"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_75970"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_390404"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00095"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00111"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_e4p_c" id="M_e4p_c" name="D-Erythrose 4-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C4H7O7P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_e4p_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/e4p"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ERYTHROSE-4P"/> + <rdf:li rdf:resource="https://identifiers.org/cas/585-18-2"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42349"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:48153"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4256"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:20927"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12921"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:21109"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27508"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4114"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16897"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01321"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C03109"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00279"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3574"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29878"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd01994"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00236"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00279"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_etoh_c" id="M_etoh_c" name="Ethanol" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2H6O"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_etoh_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/etoh"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ETOH"/> + <rdf:li rdf:resource="https://identifiers.org/cas/64-17-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4879"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30880"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16236"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30878"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:52092"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14222"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:52096"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23978"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44594"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42377"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00108"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00469"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D04855"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D06542"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00068"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D02798"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3752"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_30203"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113748"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00363"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00469"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_etoh_e" id="M_etoh_e" name="Ethanol" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2H6O"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_etoh_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/etoh"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ETOH"/> + <rdf:li rdf:resource="https://identifiers.org/cas/64-17-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4879"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30880"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16236"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30878"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:52092"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14222"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:52096"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23978"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44594"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42377"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00108"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00469"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D04855"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D06542"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00068"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D02798"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3752"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_30203"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113748"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00363"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00469"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_f6p_c" id="M_f6p_c" name="D-Fructose 6-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C6H11O9P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_f6p_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/f6p"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/FRUCTOSE-6P"/> + <rdf:li rdf:resource="https://identifiers.org/cas/643-13-0"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57634"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12352"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45804"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:61527"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:61553"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10375"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16084"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42378"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22768"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB03971"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05345"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00085"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3385"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00072"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC05345"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00085"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_fdp_c" id="M_fdp_c" name="D-Fructose 1,6-bisphosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C6H10O12P2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_fdp_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/fdp"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/FRUCTOSE-16-DIPHOSPHATE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/488-69-7"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32968"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:49299"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42553"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32966"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37736"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28013"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32967"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:41014"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22767"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10374"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40595"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:40591"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05378"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00354"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3647"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00290"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00354"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_for_c" id="M_for_c" name="Formate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="CH1O2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_for_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/for"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/FORMATE"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CARBOXYL-GROUP"/> + <rdf:li rdf:resource="https://identifiers.org/cas/64-18-6"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42460"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14276"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63050"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5145"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24082"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24081"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30751"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63880"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15740"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:52343"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00142"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00058"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01010040"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3358"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389585"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29460"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00047"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00058"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_for_e" id="M_for_e" name="Formate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="CH1O2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_for_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/for"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/FORMATE"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CARBOXYL-GROUP"/> + <rdf:li rdf:resource="https://identifiers.org/cas/64-18-6"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42460"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14276"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63050"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5145"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24082"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24081"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30751"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63880"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15740"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:52343"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00142"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00058"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01010040"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3358"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389585"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29460"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00047"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00058"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_fru_e" id="M_fru_e" name="D-Fructose" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H12O6"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_fru_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/fru"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CPD-10723"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/BETA-D-FRUCTOSE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/57-48-7"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5172"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10373"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37721"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37720"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28757"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:48673"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24104"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:49089"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22766"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42560"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24110"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28645"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00660"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C02336"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00095"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3395"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00082"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00095"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_fum_c" id="M_fum_c" name="Fumarate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C4H2O4"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_fum_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/fum"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/FUM"/> + <rdf:li rdf:resource="https://identifiers.org/cas/110-17-8"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42743"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18012"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5190"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22958"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24122"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24124"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22956"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22957"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37154"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37155"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42511"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29806"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:36180"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14284"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00134"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00122"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D02308"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3422"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29586"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113588"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00106"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00122"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_fum_e" id="M_fum_e" name="Fumarate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C4H2O4"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_fum_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/fum"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/FUM"/> + <rdf:li rdf:resource="https://identifiers.org/cas/110-17-8"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42743"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18012"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5190"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22958"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24122"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24124"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22956"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22957"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37154"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37155"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42511"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29806"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:36180"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14284"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00134"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00122"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D02308"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3422"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29586"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113588"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00106"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00122"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_g3p_c" id="M_g3p_c" name="Glyceraldehyde 3-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C3H5O6P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_g3p_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/g3p"/> + <rdf:li rdf:resource="https://identifiers.org/cas/142-10-9"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17138"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14333"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5446"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:58027"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01112"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00661"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00118"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3930"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00102"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00661"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00118"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_g6p_c" id="M_g6p_c" name="D-Glucose 6-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C6H11O9P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_g6p_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/g6p"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/D-glucose-6-phosphate"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/GLC-6-P"/> + <rdf:li rdf:resource="https://identifiers.org/cas/56-73-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10399"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22797"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:41041"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17719"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4170"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:61548"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:58247"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12375"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB03498"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB06793"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01401"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01549"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00092"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01172"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3392"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1629756"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00079"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00092"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_glc__D_e" id="M_glc__D_e" name="D-Glucose" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H12O6"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_glc__D_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/glc__D"/> + <rdf:li rdf:resource="https://identifiers.org/cas/50-99-7"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00031"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3333"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_gln__L_c" id="M_gln__L_c" name="L-Glutamine" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H10N2O3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_gln__L_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/gln__L"/> + <rdf:li rdf:resource="https://identifiers.org/cas/56-85-9"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00064"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3364"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_gln__L_e" id="M_gln__L_e" name="L-Glutamine" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C5H10N2O3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_gln__L_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/gln__L"/> + <rdf:li rdf:resource="https://identifiers.org/cas/56-85-9"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00064"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3364"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_glu__L_c" id="M_glu__L_c" name="L-Glutamate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C5H8NO4"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_glu__L_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/glu__L"/> + <rdf:li rdf:resource="https://identifiers.org/cas/56-86-0"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00025"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3327"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_glu__L_e" id="M_glu__L_e" name="L-Glutamate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C5H8NO4"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_glu__L_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/glu__L"/> + <rdf:li rdf:resource="https://identifiers.org/cas/56-86-0"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00025"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3327"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_glx_c" id="M_glx_c" name="Glyoxylate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C2H1O3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_glx_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/glx"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/GLYOX"/> + <rdf:li rdf:resource="https://identifiers.org/cas/298-12-4"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:36655"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42767"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14368"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:35977"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24421"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24420"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16891"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5509"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00119"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00048"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3350"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_904849"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389678"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00040"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00048"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_h2o_c" id="M_h2o_c" name="H2O" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="H2O"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_h2o_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/h2o"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/WATER"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/OH"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/OXONIUM"/> + <rdf:li rdf:resource="https://identifiers.org/cas/7732-18-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15377"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13365"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:41979"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16234"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:36385"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42857"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27313"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44819"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29373"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10743"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5594"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29356"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:53442"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29375"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29374"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13419"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:43228"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44292"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13352"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:41981"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29412"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42043"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:33811"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:33813"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:35511"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5585"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44641"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44701"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01039"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB02111"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01328"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00001"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C18714"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C18712"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00001"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D06322"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D03703"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3303"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_947593"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_189422"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_141343"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113518"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1605715"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_109276"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113521"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113519"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2022884"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_351603"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29356"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd15275"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00001"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00001"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC01328"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_h2o_e" id="M_h2o_e" name="H2O" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="H2O"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_h2o_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/h2o"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/WATER"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/OH"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/OXONIUM"/> + <rdf:li rdf:resource="https://identifiers.org/cas/7732-18-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15377"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13365"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:41979"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16234"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:36385"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42857"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27313"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44819"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29373"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10743"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5594"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29356"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:53442"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29375"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29374"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13419"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:43228"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44292"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13352"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:41981"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29412"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:42043"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:33811"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:33813"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:35511"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5585"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44641"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44701"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01039"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB02111"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01328"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00001"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C18714"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C18712"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00001"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D06322"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D03703"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3303"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_947593"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_189422"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_141343"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113518"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1605715"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_109276"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113521"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113519"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2022884"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_351603"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29356"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd15275"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00001"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00001"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC01328"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_h_c" id="M_h_c" name="H+" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="1" fbc:chemicalFormula="H"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_h_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/h"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/PROTON"/> + <rdf:li rdf:resource="https://identifiers.org/cas/12408-02-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24636"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15378"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10744"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13357"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5584"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00080"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3380"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_194688"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_425978"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_193465"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_374900"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_74722"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_425999"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_428040"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_163953"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_372511"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2000349"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_70106"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1470067"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113529"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_425969"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_428548"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_156540"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1614597"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_351626"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_427899"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00067"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00080"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_h_e" id="M_h_e" name="H+" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="1" fbc:chemicalFormula="H"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_h_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/h"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/PROTON"/> + <rdf:li rdf:resource="https://identifiers.org/cas/12408-02-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24636"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15378"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10744"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13357"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5584"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00080"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3380"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_194688"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_425978"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_193465"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_374900"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_74722"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_425999"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_428040"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_163953"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_372511"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2000349"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_70106"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1470067"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113529"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_425969"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_428548"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_156540"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1614597"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_351626"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_427899"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00067"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00080"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_icit_c" id="M_icit_c" name="Isocitrate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C6H5O7"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_icit_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/icit"/> + <rdf:li rdf:resource="https://identifiers.org/cas/30810-51-6"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14465"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24886"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24884"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:36454"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16087"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5998"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30887"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:36453"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00193"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00311"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3605"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00260"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00311"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_lac__D_c" id="M_lac__D_c" name="D-Lactate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C3H5O3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_lac__D_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/lac__D"/> + <rdf:li rdf:resource="https://identifiers.org/cas/10326-41-7"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00256"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3555"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_lac__D_e" id="M_lac__D_e" name="D-Lactate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C3H5O3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_lac__D_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/lac__D"/> + <rdf:li rdf:resource="https://identifiers.org/cas/10326-41-7"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00256"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3555"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_mal__L_c" id="M_mal__L_c" name="L-Malate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C4H4O5"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_mal__L_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/mal__L"/> + <rdf:li rdf:resource="https://identifiers.org/cas/97-67-6"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00149"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3449"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_mal__L_e" id="M_mal__L_e" name="L-Malate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C4H4O5"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_mal__L_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/mal__L"/> + <rdf:li rdf:resource="https://identifiers.org/cas/97-67-6"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00149"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3449"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_nad_c" id="M_nad_c" name="Nicotinamide adenine dinucleotide" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C21H26N7O14P2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_nad_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nad"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/NAD"/> + <rdf:li rdf:resource="https://identifiers.org/cas/53-84-9"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:21901"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7422"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44214"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15846"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13394"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13393"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44215"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13389"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57540"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44281"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00902"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00003"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00002"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3305"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_192307"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29360"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_427523"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_194653"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113526"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00003"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00003"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_nadh_c" id="M_nadh_c" name="Nicotinamide adenine dinucleotide - reduced" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C21H27N7O14P2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_nadh_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nadh"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/NADH"/> + <rdf:li rdf:resource="https://identifiers.org/cas/58-68-4"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13395"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:21902"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16908"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7423"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44216"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57945"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13396"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01487"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00004"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3306"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_192305"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_73473"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_194697"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29362"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00004"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00004"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_nadp_c" id="M_nadp_c" name="Nicotinamide adenine dinucleotide phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C21H25N7O17P3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_nadp_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nadp"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/NADP"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/NAD-P-OR-NOP"/> + <rdf:li rdf:resource="https://identifiers.org/cas/53-59-8"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7424"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13398"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13397"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13390"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:25524"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:25523"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44405"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44409"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18009"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:58349"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:21903"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00217"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00006"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3308"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29366"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2000348"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113563"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113564"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389556"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_428218"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_351628"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_194668"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_517495"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00006"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00006"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_nadph_c" id="M_nadph_c" name="Nicotinamide adenine dinucleotide phosphate - reduced" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C21H26N7O17P3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_nadph_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nadph"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/NADH-P-OR-NOP"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/NADPH"/> + <rdf:li rdf:resource="https://identifiers.org/cas/2646-71-1"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13400"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16474"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7425"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13399"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13392"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57783"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:21904"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44286"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00799"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB06341"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00221"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00005"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3307"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2000347"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29364"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_428206"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113602"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113600"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113601"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_194725"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_517496"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_351627"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00005"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00005"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_nh4_c" id="M_nh4_c" name="Ammonium" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="1" fbc:chemicalFormula="H4N"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_nh4_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nh4"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/AMMONIUM"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/NH4OH"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/AMMONIA"/> + <rdf:li rdf:resource="https://identifiers.org/cas/14798-03-9"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13408"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13405"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13406"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13407"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28938"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:62982"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44269"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:66871"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18219"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16134"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29337"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:49783"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44404"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7436"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7435"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7434"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22533"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22534"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22535"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29340"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63040"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13772"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13771"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29240"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44284"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00051"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01358"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00014"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01342"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D02916"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D02915"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D04594"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/4547"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_140912"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2022135"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_76230"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113561"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389843"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29382"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_31633"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00013"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00014"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_nh4_e" id="M_nh4_e" name="Ammonium" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="1" fbc:chemicalFormula="H4N"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_nh4_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nh4"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/AMMONIUM"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/NH4OH"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/AMMONIA"/> + <rdf:li rdf:resource="https://identifiers.org/cas/14798-03-9"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13408"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13405"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13406"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13407"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28938"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:62982"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44269"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:66871"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18219"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16134"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29337"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:49783"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44404"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7436"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7435"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7434"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22533"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22534"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22535"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29340"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63040"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13772"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13771"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29240"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44284"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00051"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01358"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00014"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01342"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D02916"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D02915"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D04594"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/4547"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_140912"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2022135"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_76230"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113561"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389843"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29382"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_31633"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00013"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00014"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_o2_c" id="M_o2_c" name="O2" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="O2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_o2_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/o2"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/OXYGEN-MOLECULE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/7782-44-7"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44742"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27140"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15379"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:25366"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26689"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30491"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13416"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29793"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23833"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7860"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10745"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01377"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00007"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00003"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3309"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113534"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29368"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113535"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1236709"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113533"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_189461"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113685"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_352327"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_351593"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00532"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00007"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_o2_e" id="M_o2_e" name="O2" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="O2"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_o2_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/o2"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/OXYGEN-MOLECULE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/7782-44-7"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44742"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27140"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15379"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:25366"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26689"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30491"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:13416"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29793"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23833"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7860"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10745"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01377"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00007"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D00003"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3309"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113534"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29368"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113535"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1236709"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113533"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_189461"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113685"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_352327"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_351593"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00532"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00007"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_oaa_c" id="M_oaa_c" name="Oxaloacetate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C4H2O5"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_oaa_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/oaa"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/OXALACETIC_ACID"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/ENOL-OXALOACETATE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/328-42-7"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23911"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:23910"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12810"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10547"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16452"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17479"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30744"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7812"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:19638"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:25734"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:25731"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12820"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:1158"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14703"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28394"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24958"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24959"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00223"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C03981"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00036"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01170061"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01170120"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3338"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_76213"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113587"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00032"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00036"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_pep_c" id="M_pep_c" name="Phosphoenolpyruvate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C3H2O6P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_pep_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/pep"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/PHOSPHO-ENOL-PYRUVATE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/138-08-9"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44897"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:44894"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14812"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:8147"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26055"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26054"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:58702"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18021"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00263"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00074"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3374"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29492"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_372364"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00061"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00074"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_pi_c" id="M_pi_c" name="Phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="HO4P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_pi_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/pi"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/Pi"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/PHOSPHATE-GROUP"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CPD0-1421"/> + <rdf:li rdf:resource="https://identifiers.org/cas/14265-44-2"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37583"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7793"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37585"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:34683"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14791"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:34855"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29137"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29139"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63036"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26020"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:39739"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32597"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32596"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:43474"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63051"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:43470"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:9679"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:35433"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4496"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45024"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18367"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26078"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:39745"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24838"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB02142"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C13556"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C13558"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00009"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D05467"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3311"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_947590"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_109277"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113548"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2255331"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29372"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113550"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113551"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd09464"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd09463"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00009"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00009"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_pi_e" id="M_pi_e" name="Phosphate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="HO4P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_pi_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/pi"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/Pi"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/PHOSPHATE-GROUP"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CPD0-1421"/> + <rdf:li rdf:resource="https://identifiers.org/cas/14265-44-2"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37583"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:7793"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37585"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:34683"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14791"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:34855"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29137"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:29139"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63036"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26020"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:39739"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32597"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32596"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:43474"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63051"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:43470"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:9679"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:35433"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4496"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45024"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18367"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26078"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:39745"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:24838"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB02142"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C13556"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C13558"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00009"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.drug/D05467"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3311"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_947590"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_109277"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113548"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_2255331"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29372"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113550"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113551"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd09464"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd09463"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00009"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00009"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_pyr_c" id="M_pyr_c" name="Pyruvate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C3H3O3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_pyr_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/pyr"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/PYRUVATE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/127-17-3"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15361"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14987"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:8685"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32816"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45253"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26466"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26462"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00243"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00022"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01060077"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3324"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113557"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389680"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29398"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00020"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00022"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_pyr_e" id="M_pyr_e" name="Pyruvate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C3H3O3"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_pyr_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/pyr"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/PYRUVATE"/> + <rdf:li rdf:resource="https://identifiers.org/cas/127-17-3"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15361"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:14987"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:8685"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:32816"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45253"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26466"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26462"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00243"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00022"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01060077"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3324"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113557"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389680"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29398"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00020"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00022"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_q8_c" id="M_q8_c" name="Ubiquinone-8" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C49H74O4"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_q8_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/q8"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/UBIQUINONE-8"/> + <rdf:li rdf:resource="https://identifiers.org/cas/1339-63-5"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:61683"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C17569"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00399"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMPR02010005"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3689"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd15560"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_q8h2_c" id="M_q8h2_c" name="Ubiquinol-8" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C49H76O4"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_q8h2_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/q8h2"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/CPD-9956"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:61682"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00390"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3680"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd15561"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_r5p_c" id="M_r5p_c" name="alpha-D-Ribose 5-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C5H9O8P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_r5p_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/r5p"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/RIBOSE-5P"/> + <rdf:li rdf:resource="https://identifiers.org/cas/4300-28-1"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:12331"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:52742"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10270"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22413"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18189"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00618"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01548"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB02033"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB02694"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00117"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C03736"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3417"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00101"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00117"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_ru5p__D_c" id="M_ru5p__D_c" name="D-Ribulose 5-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C5H9O8P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_ru5p__D_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/ru5p__D"/> + <rdf:li rdf:resource="https://identifiers.org/cas/4151-19-3"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00199"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3499"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_s7p_c" id="M_s7p_c" name="Sedoheptulose 7-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C7H13O10P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_s7p_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/s7p"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/D-SEDOHEPTULOSE-7-P"/> + <rdf:li rdf:resource="https://identifiers.org/cas/583-08-4"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26621"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57483"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:9083"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15721"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4244"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15074"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15073"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05382"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00281"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3576"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29882"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00238"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC05382"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_succ_c" id="M_succ_c" name="Succinate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C4H4O4"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_succ_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/succ"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/SUC"/> + <rdf:li rdf:resource="https://identifiers.org/cas/110-15-6"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22941"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22943"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26807"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26803"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30031"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:9304"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15125"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45639"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15741"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30779"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00254"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00042"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01170043"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3344"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113536"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_433123"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29434"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389583"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1650769"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_159939"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00036"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00042"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_succ_e" id="M_succ_e" name="Succinate" compartment="e" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C4H4O4"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_succ_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/succ"/> + <rdf:li rdf:resource="https://identifiers.org/biocyc/SUC"/> + <rdf:li rdf:resource="https://identifiers.org/cas/110-15-6"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22941"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:22943"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26807"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26803"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30031"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:9304"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15125"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45639"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15741"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:30779"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB00254"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00042"/> + <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA01170043"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3344"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_113536"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_433123"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_29434"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_389583"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_1650769"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_159939"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00036"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00042"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_succoa_c" id="M_succoa_c" name="Succinyl-CoA" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-5" fbc:chemicalFormula="C25H35N7O19P3S"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_succoa_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/succoa"/> + <rdf:li rdf:resource="https://identifiers.org/cas/604-98-8"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15127"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15380"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57292"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:26811"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:9310"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:45541"/> + <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:10746"/> + <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB01022"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00091"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3391"/> + <rdf:li rdf:resource="https://identifiers.org/reactome/REACT_70958"/> + <rdf:li rdf:resource="https://identifiers.org/seed.compound/cpd00078"/> + <rdf:li rdf:resource="https://identifiers.org/unipathway.compound/UPC00091"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + <species metaid="meta_M_xu5p__D_c" id="M_xu5p__D_c" name="D-Xylulose 5-phosphate" compartment="c" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C5H9O8P"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_M_xu5p__D_c"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/xu5p__D"/> + <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00231"/> + <rdf:li rdf:resource="https://identifiers.org/pubchem.substance/3530"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </species> + </listOfSpecies> + <listOfParameters> + <parameter sboTerm="SBO:0000626" id="cobra_default_lb" value="-1000" constant="true"/> + <parameter sboTerm="SBO:0000626" id="cobra_default_ub" value="1000" constant="true"/> + <parameter sboTerm="SBO:0000626" id="cobra_0_bound" value="0" constant="true"/> + <parameter sboTerm="SBO:0000626" id="minus_inf" value="-INF" constant="true"/> + <parameter sboTerm="SBO:0000626" id="plus_inf" value="INF" constant="true"/> + <parameter sboTerm="SBO:0000625" id="R_ATPM_lower_bound" value="8.39" units="mmol_per_gDW_per_hr" constant="true"/> + <parameter sboTerm="SBO:0000625" id="R_EX_glc__D_e_lower_bound" value="-10" units="mmol_per_gDW_per_hr" constant="true"/> + </listOfParameters> + <listOfReactions> + <reaction metaid="meta_R_ACALD" id="R_ACALD" name="acetaldehyde dehydrogenase (acetylating)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ACALD"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACALD"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_acald_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b0351"/> + <fbc:geneProductRef fbc:geneProduct="G_b1241"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ACALDt" id="R_ACALDt" name="R acetaldehyde reversible - transport" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ACALDt"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACALDt"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_acald_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_acald_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_s0001"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ACKr" id="R_ACKr" name="acetate kinase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ACKr"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACKr"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b2296"/> + <fbc:geneProductRef fbc:geneProduct="G_b3115"/> + <fbc:geneProductRef fbc:geneProduct="G_b1849"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ACONTa" id="R_ACONTa" name="aconitase (half-reaction A, Citrate hydro-lyase)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ACONTa"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACONTa"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_acon_C_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b0118"/> + <fbc:geneProductRef fbc:geneProduct="G_b1276"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ACONTb" id="R_ACONTb" name="aconitase (half-reaction B, Isocitrate hydro-lyase)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ACONTb"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACONTb"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_acon_C_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b0118"/> + <fbc:geneProductRef fbc:geneProduct="G_b1276"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ACt2r" id="R_ACt2r" name="R acetate reversible transport via proton - symport" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ACt2r"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACt2r"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_ac_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_ac_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + </listOfProducts> + </reaction> + <reaction metaid="meta_R_ADK1" id="R_ADK1" name="adenylate kinase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ADK1"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ADK1"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_adp_c" stoichiometry="2" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b0474"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_AKGDH" id="R_AKGDH" name="2-Oxogluterate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_AKGDH"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AKGDH"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0726"/> + <fbc:geneProductRef fbc:geneProduct="G_b0116"/> + <fbc:geneProductRef fbc:geneProduct="G_b0727"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_AKGt2r" id="R_AKGt2r" name="R 2 oxoglutarate reversible transport via - symport" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_AKGt2r"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/AKGt2r"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_akg_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b2587"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ALCD2x" id="R_ALCD2x" name="alcohol dehydrogenase (ethanol)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ALCD2x"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ALCD2x"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_acald_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b1478"/> + <fbc:geneProductRef fbc:geneProduct="G_b0356"/> + <fbc:geneProductRef fbc:geneProduct="G_b1241"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ATPM" id="R_ATPM" name="ATP maintenance requirement" reversible="false" fast="false" fbc:lowerFluxBound="R_ATPM_lower_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ATPM"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ATPM"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfProducts> + </reaction> + <reaction metaid="meta_R_ATPS4r" id="R_ATPS4r" name="ATP synthase (four protons for one ATP)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ATPS4r"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ATPS4r"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_e" stoichiometry="4" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="3" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b3738"/> + <fbc:geneProductRef fbc:geneProduct="G_b3736"/> + <fbc:geneProductRef fbc:geneProduct="G_b3737"/> + <fbc:geneProductRef fbc:geneProduct="G_b3735"/> + <fbc:geneProductRef fbc:geneProduct="G_b3733"/> + <fbc:geneProductRef fbc:geneProduct="G_b3731"/> + <fbc:geneProductRef fbc:geneProduct="G_b3732"/> + <fbc:geneProductRef fbc:geneProduct="G_b3734"/> + </fbc:and> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b3734"/> + <fbc:geneProductRef fbc:geneProduct="G_b3732"/> + <fbc:geneProductRef fbc:geneProduct="G_b3731"/> + <fbc:geneProductRef fbc:geneProduct="G_b3733"/> + <fbc:geneProductRef fbc:geneProduct="G_b3735"/> + <fbc:geneProductRef fbc:geneProduct="G_b3737"/> + <fbc:geneProductRef fbc:geneProduct="G_b3736"/> + <fbc:geneProductRef fbc:geneProduct="G_b3738"/> + <fbc:geneProductRef fbc:geneProduct="G_b3739"/> + </fbc:and> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_Biomass_Ecoli_core" sboTerm="SBO:0000629" id="R_Biomass_Ecoli_core" name="Biomass Objective Function with GAM" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_Biomass_Ecoli_core"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/Ecoli_core_w_GAM"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_3pg_c" stoichiometry="1.496" constant="true"/> + <speciesReference species="M_accoa_c" stoichiometry="3.7478" constant="true"/> + <speciesReference species="M_atp_c" stoichiometry="59.81" constant="true"/> + <speciesReference species="M_e4p_c" stoichiometry="0.361" constant="true"/> + <speciesReference species="M_f6p_c" stoichiometry="0.0709" constant="true"/> + <speciesReference species="M_g3p_c" stoichiometry="0.129" constant="true"/> + <speciesReference species="M_g6p_c" stoichiometry="0.205" constant="true"/> + <speciesReference species="M_gln__L_c" stoichiometry="0.2557" constant="true"/> + <speciesReference species="M_glu__L_c" stoichiometry="4.9414" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="59.81" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="3.547" constant="true"/> + <speciesReference species="M_nadph_c" stoichiometry="13.0279" constant="true"/> + <speciesReference species="M_oaa_c" stoichiometry="1.7867" constant="true"/> + <speciesReference species="M_pep_c" stoichiometry="0.5191" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="2.8328" constant="true"/> + <speciesReference species="M_r5p_c" stoichiometry="0.8977" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_adp_c" stoichiometry="59.81" constant="true"/> + <speciesReference species="M_akg_c" stoichiometry="4.1182" constant="true"/> + <speciesReference species="M_coa_c" stoichiometry="3.7478" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="59.81" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="3.547" constant="true"/> + <speciesReference species="M_nadp_c" stoichiometry="13.0279" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="59.81" constant="true"/> + </listOfProducts> + </reaction> + <reaction metaid="meta_R_CO2t" id="R_CO2t" name="R CO2 transporter via - diffusion" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_CO2t"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CO2t"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_co2_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_s0001"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_CS" id="R_CS" name="citrate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_CS"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CS"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_cit_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b0720"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_CYTBD" id="R_CYTBD" name="cytochrome oxidase bd (ubiquinol-8: 2 protons)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_CYTBD"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CYTBD"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_c" stoichiometry="2" constant="true"/> + <speciesReference species="M_o2_c" stoichiometry="0.5" constant="true"/> + <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_e" stoichiometry="2" constant="true"/> + <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0978"/> + <fbc:geneProductRef fbc:geneProduct="G_b0979"/> + </fbc:and> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0733"/> + <fbc:geneProductRef fbc:geneProduct="G_b0734"/> + </fbc:and> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_D_LACt2" id="R_D_LACt2" name="R D lactate transport via proton - symport" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_D_LACt2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/D_LACt2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_lac__D_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_lac__D_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b2975"/> + <fbc:geneProductRef fbc:geneProduct="G_b3603"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ENO" id="R_ENO" name="enolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ENO"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ENO"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b2779"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ETOHt2r" id="R_ETOHt2r" name="ETOHt2r" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ETOHt2r"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ETOHt2r"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_etoh_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_etoh_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + </listOfProducts> + </reaction> + <reaction metaid="meta_R_EX_ac_e" sboTerm="SBO:0000627" id="R_EX_ac_e" name="Acetate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_ac_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ac"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_ac_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_acald_e" sboTerm="SBO:0000627" id="R_EX_acald_e" name="Acetaldehyde exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_acald_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/acald"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_acald_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_akg_e" sboTerm="SBO:0000627" id="R_EX_akg_e" name="2-Oxoglutarate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_akg_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/akg"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_akg_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_co2_e" sboTerm="SBO:0000627" id="R_EX_co2_e" name="CO2 exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_co2_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/co2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_co2_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_etoh_e" sboTerm="SBO:0000627" id="R_EX_etoh_e" name="Ethanol exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_etoh_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/etoh"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_etoh_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_for_e" sboTerm="SBO:0000627" id="R_EX_for_e" name="Formate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_for_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/for"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_for_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_fru_e" sboTerm="SBO:0000627" id="R_EX_fru_e" name="D-Fructose exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_fru_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/fru"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_fru_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_fum_e" sboTerm="SBO:0000627" id="R_EX_fum_e" name="Fumarate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_fum_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/fum"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_fum_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_glc__D_e" sboTerm="SBO:0000627" id="R_EX_glc__D_e" name="D-Glucose exchange" reversible="true" fast="false" fbc:lowerFluxBound="R_EX_glc__D_e_lower_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_glc__D_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/glc"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_glc__D_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_gln__L_e" sboTerm="SBO:0000627" id="R_EX_gln__L_e" name="L-Glutamine exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_gln__L_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/gln__L"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_gln__L_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_glu__L_e" sboTerm="SBO:0000627" id="R_EX_glu__L_e" name="L-Glutamate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_glu__L_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/glu__L"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_glu__L_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_h_e" sboTerm="SBO:0000627" id="R_EX_h_e" name="H+ exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_h_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/h"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_h2o_e" sboTerm="SBO:0000627" id="R_EX_h2o_e" name="H2O exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_h2o_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/h2o"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h2o_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_lac__D_e" sboTerm="SBO:0000627" id="R_EX_lac__D_e" name="D-lactate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_lac__D_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/lac__D"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_lac__D_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_mal__L_e" sboTerm="SBO:0000627" id="R_EX_mal__L_e" name="L-Malate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_mal__L_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/mal__L"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_mal__L_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_nh4_e" sboTerm="SBO:0000627" id="R_EX_nh4_e" name="Ammonia exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_nh4_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/nh4"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_nh4_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_o2_e" sboTerm="SBO:0000627" id="R_EX_o2_e" name="O2 exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_o2_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/o2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_o2_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_pi_e" sboTerm="SBO:0000627" id="R_EX_pi_e" name="Phosphate exchange" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_pi_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/pi"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_pi_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_pyr_e" sboTerm="SBO:0000627" id="R_EX_pyr_e" name="Pyruvate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_pyr_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/pyr"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_pyr_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_EX_succ_e" sboTerm="SBO:0000627" id="R_EX_succ_e" name="Succinate exchange" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_EX_succ_e"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/succ"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_succ_e" stoichiometry="1" constant="true"/> + </listOfReactants> + </reaction> + <reaction metaid="meta_R_FBA" id="R_FBA" name="fructose-bisphosphate aldolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_FBA"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FBA"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b1773"/> + <fbc:geneProductRef fbc:geneProduct="G_b2097"/> + <fbc:geneProductRef fbc:geneProduct="G_b2925"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_FBP" id="R_FBP" name="fructose-bisphosphatase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_FBP"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FBP"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b3925"/> + <fbc:geneProductRef fbc:geneProduct="G_b4232"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_FORt2" id="R_FORt2" name="formate transport in via proton symport" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_FORt2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FORt2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_for_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_for_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b0904"/> + <fbc:geneProductRef fbc:geneProduct="G_b2492"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_FORti" id="R_FORti" name="formate transport via diffusion" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_FORti"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FORti"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_for_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_for_e" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b0904"/> + <fbc:geneProductRef fbc:geneProduct="G_b2492"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_FRD7" id="R_FRD7" name="fumarate reductase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_FRD7"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FRD7"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b4153"/> + <fbc:geneProductRef fbc:geneProduct="G_b4151"/> + <fbc:geneProductRef fbc:geneProduct="G_b4152"/> + <fbc:geneProductRef fbc:geneProduct="G_b4154"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_FRUpts2" id="R_FRUpts2" name="R Fructose transport via PEPPyr PTS-f6p - generating" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_FRUpts2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FRUpts2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_fru_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b2415"/> + <fbc:geneProductRef fbc:geneProduct="G_b1818"/> + <fbc:geneProductRef fbc:geneProduct="G_b1817"/> + <fbc:geneProductRef fbc:geneProduct="G_b1819"/> + <fbc:geneProductRef fbc:geneProduct="G_b2416"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_FUM" id="R_FUM" name="fumarase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_FUM"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FUM"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b4122"/> + <fbc:geneProductRef fbc:geneProduct="G_b1612"/> + <fbc:geneProductRef fbc:geneProduct="G_b1611"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_FUMt2_2" id="R_FUMt2_2" name="R Fumarate transport via proton symport-2 - H" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_FUMt2_2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FUMt2_2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_fum_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_e" stoichiometry="2" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="2" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b3528"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_G6PDH2r" id="R_G6PDH2r" name="glucose 6-phosphate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_G6PDH2r"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G6PDH2r"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_6pgl_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b1852"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_GAPD" id="R_GAPD" name="glyceraldehyde-3-phosphate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_GAPD"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GAPD"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b1779"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_GLCpts" id="R_GLCpts" name="D-glucose transport via PEP:Pyr PTS" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_GLCpts"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLCpts"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_glc__D_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b2415"/> + <fbc:geneProductRef fbc:geneProduct="G_b1818"/> + <fbc:geneProductRef fbc:geneProduct="G_b1817"/> + <fbc:geneProductRef fbc:geneProduct="G_b1819"/> + <fbc:geneProductRef fbc:geneProduct="G_b2416"/> + </fbc:and> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b2415"/> + <fbc:geneProductRef fbc:geneProduct="G_b2417"/> + <fbc:geneProductRef fbc:geneProduct="G_b1101"/> + <fbc:geneProductRef fbc:geneProduct="G_b2416"/> + </fbc:and> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b2415"/> + <fbc:geneProductRef fbc:geneProduct="G_b2417"/> + <fbc:geneProductRef fbc:geneProduct="G_b1621"/> + <fbc:geneProductRef fbc:geneProduct="G_b2416"/> + </fbc:and> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_GLNS" id="R_GLNS" name="glutamine synthetase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_GLNS"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLNS"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b3870"/> + <fbc:geneProductRef fbc:geneProduct="G_b1297"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_GLNabc" id="R_GLNabc" name="GLNabc" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_GLNabc"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLNabc"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_gln__L_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0810"/> + <fbc:geneProductRef fbc:geneProduct="G_b0811"/> + <fbc:geneProductRef fbc:geneProduct="G_b0809"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_GLUDy" id="R_GLUDy" name="glutamate dehydrogenase (NADP)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_GLUDy"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUDy"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b1761"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_GLUN" id="R_GLUN" name="glutaminase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_GLUN"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUN"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b0485"/> + <fbc:geneProductRef fbc:geneProduct="G_b1812"/> + <fbc:geneProductRef fbc:geneProduct="G_b1524"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_GLUSy" id="R_GLUSy" name="glutamate synthase (NADPH)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_GLUSy"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUSy"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_gln__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_glu__L_c" stoichiometry="2" constant="true"/> + <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b3212"/> + <fbc:geneProductRef fbc:geneProduct="G_b3213"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_GLUt2r" id="R_GLUt2r" name="R L glutamate transport via proton - symport-reversible" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_GLUt2r"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUt2r"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_glu__L_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_glu__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b4077"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_GND" id="R_GND" name="phosphogluconate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_GND"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GND"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b2029"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_H2Ot" id="R_H2Ot" name="R H2O transport via - diffusion" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_H2Ot"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/H2Ot"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h2o_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b0875"/> + <fbc:geneProductRef fbc:geneProduct="G_s0001"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ICDHyr" id="R_ICDHyr" name="isocitrate dehydrogenase (NADP)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ICDHyr"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ICDHyr"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_akg_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b1136"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ICL" id="R_ICL" name="Isocitrate lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ICL"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ICL"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_icit_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b4015"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_LDH_D" id="R_LDH_D" name="D-lactate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_LDH_D"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/LDH_D"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_lac__D_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b2133"/> + <fbc:geneProductRef fbc:geneProduct="G_b1380"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_MALS" id="R_MALS" name="malate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_MALS"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MALS"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_glx_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b4014"/> + <fbc:geneProductRef fbc:geneProduct="G_b2976"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_MALt2_2" id="R_MALt2_2" name="R Malate transport via proton symport-2 - H" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_MALt2_2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MALt2_2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_e" stoichiometry="2" constant="true"/> + <speciesReference species="M_mal__L_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="2" constant="true"/> + <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b3528"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_MDH" id="R_MDH" name="malate dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_MDH"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MDH"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b3236"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ME1" id="R_ME1" name="malic enzyme (NAD)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ME1"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ME1"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b1479"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_ME2" id="R_ME2" name="malic enzyme (NADP)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_ME2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ME2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_mal__L_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b2463"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_NADH16" id="R_NADH16" name="NADH dehydrogenase (ubiquinone-8 & 3 protons)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_NADH16"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADH16"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_c" stoichiometry="4" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_e" stoichiometry="3" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b2287"/> + <fbc:geneProductRef fbc:geneProduct="G_b2285"/> + <fbc:geneProductRef fbc:geneProduct="G_b2283"/> + <fbc:geneProductRef fbc:geneProduct="G_b2281"/> + <fbc:geneProductRef fbc:geneProduct="G_b2279"/> + <fbc:geneProductRef fbc:geneProduct="G_b2277"/> + <fbc:geneProductRef fbc:geneProduct="G_b2276"/> + <fbc:geneProductRef fbc:geneProduct="G_b2278"/> + <fbc:geneProductRef fbc:geneProduct="G_b2280"/> + <fbc:geneProductRef fbc:geneProduct="G_b2282"/> + <fbc:geneProductRef fbc:geneProduct="G_b2284"/> + <fbc:geneProductRef fbc:geneProduct="G_b2286"/> + <fbc:geneProductRef fbc:geneProduct="G_b2288"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_NADTRHD" id="R_NADTRHD" name="NAD transhydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_NADTRHD"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NADTRHD"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b3962"/> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b1602"/> + <fbc:geneProductRef fbc:geneProduct="G_b1603"/> + </fbc:and> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_NH4t" id="R_NH4t" name="R ammonia reversible - transport" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_NH4t"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/NH4t"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_nh4_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_nh4_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_s0001"/> + <fbc:geneProductRef fbc:geneProduct="G_b0451"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_O2t" id="R_O2t" name="R o2 - transport-diffusion" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_O2t"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/O2t"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_o2_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_o2_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_s0001"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PDH" id="R_PDH" name="pyruvate dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PDH"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PDH"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0115"/> + <fbc:geneProductRef fbc:geneProduct="G_b0114"/> + <fbc:geneProductRef fbc:geneProduct="G_b0116"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PFK" id="R_PFK" name="phosphofructokinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PFK"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PFK"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_fdp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b3916"/> + <fbc:geneProductRef fbc:geneProduct="G_b1723"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PFL" id="R_PFL" name="pyruvate formate lyase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PFL"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PFL"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_for_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0902"/> + <fbc:geneProductRef fbc:geneProduct="G_b3114"/> + </fbc:and> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0903"/> + <fbc:geneProductRef fbc:geneProduct="G_b0902"/> + <fbc:geneProductRef fbc:geneProduct="G_b2579"/> + </fbc:and> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0902"/> + <fbc:geneProductRef fbc:geneProduct="G_b0903"/> + </fbc:and> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b3951"/> + <fbc:geneProductRef fbc:geneProduct="G_b3952"/> + </fbc:and> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PGI" id="R_PGI" name="glucose-6-phosphate isomerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PGI"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGI"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_g6p_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b4025"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PGK" id="R_PGK" name="phosphoglycerate kinase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PGK"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGK"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_13dpg_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b2926"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PGL" id="R_PGL" name="6-phosphogluconolactonase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PGL"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGL"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_6pgl_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_6pgc_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b0767"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PGM" id="R_PGM" name="phosphoglycerate mutase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PGM"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGM"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_2pg_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_3pg_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b4395"/> + <fbc:geneProductRef fbc:geneProduct="G_b3612"/> + <fbc:geneProductRef fbc:geneProduct="G_b0755"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PIt2r" id="R_PIt2r" name="R phosphate reversible transport via - symport" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PIt2r"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PIt2r"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b2987"/> + <fbc:geneProductRef fbc:geneProduct="G_b3493"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PPC" id="R_PPC" name="phosphoenolpyruvate carboxylase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PPC"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPC"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b3956"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PPCK" id="R_PPCK" name="phosphoenolpyruvate carboxykinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PPCK"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPCK"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_oaa_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_co2_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b3403"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PPS" id="R_PPS" name="phosphoenolpyruvate synthase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PPS"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPS"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h2o_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_amp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="2" constant="true"/> + <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b1702"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PTAr" id="R_PTAr" name="phosphotransacetylase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PTAr"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PTAr"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_accoa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_actp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b2297"/> + <fbc:geneProductRef fbc:geneProduct="G_b2458"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PYK" id="R_PYK" name="pyruvate kinase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PYK"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PYK"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pep_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b1854"/> + <fbc:geneProductRef fbc:geneProduct="G_b1676"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_PYRt2" id="R_PYRt2" name="R pyruvate transport in via proton - symport" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_PYRt2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PYRt2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pyr_c" stoichiometry="1" constant="true"/> + </listOfProducts> + </reaction> + <reaction metaid="meta_R_RPE" id="R_RPE" name="ribulose 5-phosphate 3-epimerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_RPE"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RPE"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b3386"/> + <fbc:geneProductRef fbc:geneProduct="G_b4301"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_RPI" id="R_RPI" name="ribose-5-phosphate isomerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_RPI"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RPI"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_ru5p__D_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b2914"/> + <fbc:geneProductRef fbc:geneProduct="G_b4090"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_SUCCt2_2" id="R_SUCCt2_2" name="R succinate transport via proton symport-2 - H" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_SUCCt2_2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCCt2_2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_e" stoichiometry="2" constant="true"/> + <speciesReference species="M_succ_e" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="2" constant="true"/> + <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b3528"/> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_SUCCt3" id="R_SUCCt3" name="succinate transport out via proton antiport" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_SUCCt3"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCCt3"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_e" stoichiometry="1" constant="true"/> + <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_succ_e" stoichiometry="1" constant="true"/> + </listOfProducts> + </reaction> + <reaction metaid="meta_R_SUCDi" id="R_SUCDi" name="succinate dehydrogenase (irreversible)" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_SUCDi"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCDi"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_q8_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_fum_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_q8h2_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0723"/> + <fbc:geneProductRef fbc:geneProduct="G_b0721"/> + <fbc:geneProductRef fbc:geneProduct="G_b0722"/> + <fbc:geneProductRef fbc:geneProduct="G_b0724"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_SUCOAS" id="R_SUCOAS" name="succinyl-CoA synthetase (ADP-forming)" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_SUCOAS"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCOAS"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_atp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_coa_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_succ_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_adp_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_pi_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_succoa_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b0728"/> + <fbc:geneProductRef fbc:geneProduct="G_b0729"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_TALA" id="R_TALA" name="transaldolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_TALA"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TALA"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b2464"/> + <fbc:geneProductRef fbc:geneProduct="G_b0008"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_THD2" id="R_THD2" name="R NAD - P-transhydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="cobra_0_bound" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_THD2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/THD2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_h_e" stoichiometry="2" constant="true"/> + <speciesReference species="M_nadh_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadp_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_h_c" stoichiometry="2" constant="true"/> + <speciesReference species="M_nad_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_nadph_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:and> + <fbc:geneProductRef fbc:geneProduct="G_b1602"/> + <fbc:geneProductRef fbc:geneProduct="G_b1603"/> + </fbc:and> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_TKT1" id="R_TKT1" name="transketolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_TKT1"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TKT1"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_r5p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_s7p_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b2935"/> + <fbc:geneProductRef fbc:geneProduct="G_b2465"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_TKT2" id="R_TKT2" name="transketolase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_TKT2"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TKT2"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_e4p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_xu5p__D_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_f6p_c" stoichiometry="1" constant="true"/> + <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:or> + <fbc:geneProductRef fbc:geneProduct="G_b2935"/> + <fbc:geneProductRef fbc:geneProduct="G_b2465"/> + </fbc:or> + </fbc:geneProductAssociation> + </reaction> + <reaction metaid="meta_R_TPI" id="R_TPI" name="triose-phosphate isomerase" reversible="true" fast="false" fbc:lowerFluxBound="cobra_default_lb" fbc:upperFluxBound="cobra_default_ub"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_R_TPI"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TPI"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + <listOfReactants> + <speciesReference species="M_dhap_c" stoichiometry="1" constant="true"/> + </listOfReactants> + <listOfProducts> + <speciesReference species="M_g3p_c" stoichiometry="1" constant="true"/> + </listOfProducts> + <fbc:geneProductAssociation> + <fbc:geneProductRef fbc:geneProduct="G_b3919"/> + </fbc:geneProductAssociation> + </reaction> + </listOfReactions> + <fbc:listOfObjectives fbc:activeObjective="obj"> + <fbc:objective fbc:id="obj" fbc:type="maximize"> + <fbc:listOfFluxObjectives> + <fbc:fluxObjective fbc:reaction="R_Biomass_Ecoli_core" fbc:coefficient="1"/> + </fbc:listOfFluxObjectives> + </fbc:objective> + </fbc:listOfObjectives> + <fbc:listOfGeneProducts> + <fbc:geneProduct fbc:id="G_b1241" fbc:name="adhE" fbc:label="G_b1241"/> + <fbc:geneProduct fbc:id="G_b0351" fbc:name="mhpF" fbc:label="G_b0351"/> + <fbc:geneProduct fbc:id="G_s0001" fbc:name="G_s0001" fbc:label="G_s0001"/> + <fbc:geneProduct fbc:id="G_b3115" fbc:name="tdcD" fbc:label="G_b3115"/> + <fbc:geneProduct metaid="meta_G_b1849" fbc:id="G_b1849" fbc:name="purT" fbc:label="G_b1849"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b1849"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652885"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b2296" fbc:id="G_b2296" fbc:name="ackA" fbc:label="G_b2296"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b2296"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652265"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b1276" fbc:name="acnA" fbc:label="G_b1276"/> + <fbc:geneProduct fbc:id="G_b0118" fbc:name="acnB" fbc:label="G_b0118"/> + <fbc:geneProduct metaid="meta_G_b0474" fbc:id="G_b0474" fbc:name="adk" fbc:label="G_b0474"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b0474"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651715"/> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652408"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b0116" fbc:name="lpd" fbc:label="G_b0116"/> + <fbc:geneProduct fbc:id="G_b0726" fbc:name="sucA" fbc:label="G_b0726"/> + <fbc:geneProduct fbc:id="G_b0727" fbc:name="sucB" fbc:label="G_b0727"/> + <fbc:geneProduct fbc:id="G_b2587" fbc:name="kgtP" fbc:label="G_b2587"/> + <fbc:geneProduct fbc:id="G_b0356" fbc:name="frmA" fbc:label="G_b0356"/> + <fbc:geneProduct fbc:id="G_b1478" fbc:name="adhP" fbc:label="G_b1478"/> + <fbc:geneProduct metaid="meta_G_b3735" fbc:id="G_b3735" fbc:name="atpH" fbc:label="G_b3735"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3735"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651812"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3733" fbc:id="G_b3733" fbc:name="atpG" fbc:label="G_b3733"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3733"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651811"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3734" fbc:id="G_b3734" fbc:name="atpA" fbc:label="G_b3734"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3734"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651808"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3732" fbc:id="G_b3732" fbc:name="atpD" fbc:label="G_b3732"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3732"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651809"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3736" fbc:id="G_b3736" fbc:name="atpF" fbc:label="G_b3736"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3736"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651810"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3738" fbc:id="G_b3738" fbc:name="atpB" fbc:label="G_b3738"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3738"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653171"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3731" fbc:id="G_b3731" fbc:name="atpC" fbc:label="G_b3731"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3731"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651807"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3737" fbc:id="G_b3737" fbc:name="atpE" fbc:label="G_b3737"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3737"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653172"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3739" fbc:id="G_b3739" fbc:name="atpI" fbc:label="G_b3739"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3739"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651813"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b0720" fbc:id="G_b0720" fbc:name="gltA" fbc:label="G_b0720"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b0720"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1001122"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b0733" fbc:id="G_b0733" fbc:name="cydA" fbc:label="G_b0733"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b0733"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652262"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b0979" fbc:name="cbdB" fbc:label="G_b0979"/> + <fbc:geneProduct fbc:id="G_b0978" fbc:name="cbdA" fbc:label="G_b0978"/> + <fbc:geneProduct metaid="meta_G_b0734" fbc:id="G_b0734" fbc:name="cydB" fbc:label="G_b0734"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b0734"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652263"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b2975" fbc:name="glcA" fbc:label="G_b2975"/> + <fbc:geneProduct fbc:id="G_b3603" fbc:name="lldP" fbc:label="G_b3603"/> + <fbc:geneProduct metaid="meta_G_b2779" fbc:id="G_b2779" fbc:name="eno" fbc:label="G_b2779"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b2779"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653839"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b1773" fbc:name="ydjI" fbc:label="G_b1773"/> + <fbc:geneProduct fbc:id="G_b2925" fbc:name="fbaA" fbc:label="G_b2925"/> + <fbc:geneProduct fbc:id="G_b2097" fbc:name="fbaB" fbc:label="G_b2097"/> + <fbc:geneProduct metaid="meta_G_b4232" fbc:id="G_b4232" fbc:name="fbp" fbc:label="G_b4232"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b4232"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652147"/> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653505"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3925" fbc:id="G_b3925" fbc:name="glpX" fbc:label="G_b3925"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3925"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653071"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b0904" fbc:name="focA" fbc:label="G_b0904"/> + <fbc:geneProduct fbc:id="G_b2492" fbc:name="focB" fbc:label="G_b2492"/> + <fbc:geneProduct metaid="meta_G_b4154" fbc:id="G_b4154" fbc:name="frdA" fbc:label="G_b4154"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b4154"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652598"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b4152" fbc:name="frdC" fbc:label="G_b4152"/> + <fbc:geneProduct fbc:id="G_b4153" fbc:name="frdB" fbc:label="G_b4153"/> + <fbc:geneProduct fbc:id="G_b4151" fbc:name="frdD" fbc:label="G_b4151"/> + <fbc:geneProduct fbc:id="G_b1819" fbc:name="manZ" fbc:label="G_b1819"/> + <fbc:geneProduct fbc:id="G_b1817" fbc:name="manX" fbc:label="G_b1817"/> + <fbc:geneProduct fbc:id="G_b2415" fbc:name="ptsH" fbc:label="G_b2415"/> + <fbc:geneProduct fbc:id="G_b1818" fbc:name="manY" fbc:label="G_b1818"/> + <fbc:geneProduct fbc:id="G_b2416" fbc:name="ptsI" fbc:label="G_b2416"/> + <fbc:geneProduct metaid="meta_G_b1611" fbc:id="G_b1611" fbc:name="fumC" fbc:label="G_b1611"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b1611"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1001573"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b4122" fbc:name="fumB" fbc:label="G_b4122"/> + <fbc:geneProduct fbc:id="G_b1612" fbc:name="fumA" fbc:label="G_b1612"/> + <fbc:geneProduct fbc:id="G_b3528" fbc:name="dctA" fbc:label="G_b3528"/> + <fbc:geneProduct metaid="meta_G_b1852" fbc:id="G_b1852" fbc:name="zwf" fbc:label="G_b1852"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b1852"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652530"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b1779" fbc:name="gapA" fbc:label="G_b1779"/> + <fbc:geneProduct fbc:id="G_b1621" fbc:name="malX" fbc:label="G_b1621"/> + <fbc:geneProduct fbc:id="G_b1101" fbc:name="ptsG" fbc:label="G_b1101"/> + <fbc:geneProduct fbc:id="G_b2417" fbc:name="crr" fbc:label="G_b2417"/> + <fbc:geneProduct metaid="meta_G_b3870" fbc:id="G_b3870" fbc:name="glnA" fbc:label="G_b3870"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3870"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652131"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b1297" fbc:name="puuA" fbc:label="G_b1297"/> + <fbc:geneProduct fbc:id="G_b0809" fbc:name="glnQ" fbc:label="G_b0809"/> + <fbc:geneProduct fbc:id="G_b0810" fbc:name="glnP" fbc:label="G_b0810"/> + <fbc:geneProduct metaid="meta_G_b0811" fbc:id="G_b0811" fbc:name="glnH" fbc:label="G_b0811"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b0811"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653403"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b1761" fbc:id="G_b1761" fbc:name="gdhA" fbc:label="G_b1761"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b1761"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1006603"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b1524" fbc:name="glsB" fbc:label="G_b1524"/> + <fbc:geneProduct fbc:id="G_b1812" fbc:name="pabB" fbc:label="G_b1812"/> + <fbc:geneProduct fbc:id="G_b0485" fbc:name="glsA" fbc:label="G_b0485"/> + <fbc:geneProduct metaid="meta_G_b3213" fbc:id="G_b3213" fbc:name="gltD" fbc:label="G_b3213"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3213"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651850"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b3212" fbc:id="G_b3212" fbc:name="gltB" fbc:label="G_b3212"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3212"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652093"/> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653782"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b4077" fbc:name="gltP" fbc:label="G_b4077"/> + <fbc:geneProduct metaid="meta_G_b2029" fbc:id="G_b2029" fbc:name="gnd" fbc:label="G_b2029"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b2029"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1001479"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b0875" fbc:name="aqpZ" fbc:label="G_b0875"/> + <fbc:geneProduct metaid="meta_G_b1136" fbc:id="G_b1136" fbc:name="icd" fbc:label="G_b1136"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b1136"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651909"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b4015" fbc:name="aceA" fbc:label="G_b4015"/> + <fbc:geneProduct fbc:id="G_b2133" fbc:name="dld" fbc:label="G_b2133"/> + <fbc:geneProduct fbc:id="G_b1380" fbc:name="ldhA" fbc:label="G_b1380"/> + <fbc:geneProduct fbc:id="G_b4014" fbc:name="aceB" fbc:label="G_b4014"/> + <fbc:geneProduct fbc:id="G_b2976" fbc:name="glcB" fbc:label="G_b2976"/> + <fbc:geneProduct fbc:id="G_b3236" fbc:name="mdh" fbc:label="G_b3236"/> + <fbc:geneProduct fbc:id="G_b1479" fbc:name="maeA" fbc:label="G_b1479"/> + <fbc:geneProduct fbc:id="G_b2463" fbc:name="maeB" fbc:label="G_b2463"/> + <fbc:geneProduct fbc:id="G_b2286" fbc:name="nuoC" fbc:label="G_b2286"/> + <fbc:geneProduct fbc:id="G_b2279" fbc:name="nuoK" fbc:label="G_b2279"/> + <fbc:geneProduct fbc:id="G_b2276" fbc:name="nuoN" fbc:label="G_b2276"/> + <fbc:geneProduct fbc:id="G_b2280" fbc:name="nuoJ" fbc:label="G_b2280"/> + <fbc:geneProduct fbc:id="G_b2288" fbc:name="nuoA" fbc:label="G_b2288"/> + <fbc:geneProduct fbc:id="G_b2284" fbc:name="nuoF" fbc:label="G_b2284"/> + <fbc:geneProduct fbc:id="G_b2287" fbc:name="nuoB" fbc:label="G_b2287"/> + <fbc:geneProduct fbc:id="G_b2281" fbc:name="nuoI" fbc:label="G_b2281"/> + <fbc:geneProduct fbc:id="G_b2277" fbc:name="nuoM" fbc:label="G_b2277"/> + <fbc:geneProduct fbc:id="G_b2285" fbc:name="nuoE" fbc:label="G_b2285"/> + <fbc:geneProduct fbc:id="G_b2282" fbc:name="nuoH" fbc:label="G_b2282"/> + <fbc:geneProduct fbc:id="G_b2278" fbc:name="nuoL" fbc:label="G_b2278"/> + <fbc:geneProduct fbc:id="G_b2283" fbc:name="nuoG" fbc:label="G_b2283"/> + <fbc:geneProduct fbc:id="G_b3962" fbc:name="sthA" fbc:label="G_b3962"/> + <fbc:geneProduct metaid="meta_G_b1602" fbc:id="G_b1602" fbc:name="pntB" fbc:label="G_b1602"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b1602"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652620"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b1603" fbc:id="G_b1603" fbc:name="pntA" fbc:label="G_b1603"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b1603"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652615"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b0451" fbc:name="amtB" fbc:label="G_b0451"/> + <fbc:geneProduct fbc:id="G_b0114" fbc:name="aceE" fbc:label="G_b0114"/> + <fbc:geneProduct fbc:id="G_b0115" fbc:name="aceF" fbc:label="G_b0115"/> + <fbc:geneProduct metaid="meta_G_b3916" fbc:id="G_b3916" fbc:name="pfkA" fbc:label="G_b3916"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3916"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1006614"/> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651919"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b1723" fbc:name="pfkB" fbc:label="G_b1723"/> + <fbc:geneProduct fbc:id="G_b0902" fbc:name="pflA" fbc:label="G_b0902"/> + <fbc:geneProduct fbc:id="G_b0903" fbc:name="pflB" fbc:label="G_b0903"/> + <fbc:geneProduct fbc:id="G_b2579" fbc:name="grcA" fbc:label="G_b2579"/> + <fbc:geneProduct fbc:id="G_b3114" fbc:name="tdcE" fbc:label="G_b3114"/> + <fbc:geneProduct fbc:id="G_b3952" fbc:name="pflC" fbc:label="G_b3952"/> + <fbc:geneProduct fbc:id="G_b3951" fbc:name="pflD" fbc:label="G_b3951"/> + <fbc:geneProduct metaid="meta_G_b4025" fbc:id="G_b4025" fbc:name="pgi" fbc:label="G_b4025"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b4025"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653253"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b2926" fbc:id="G_b2926" fbc:name="pgk" fbc:label="G_b2926"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b2926"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653609"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b0767" fbc:name="pgl" fbc:label="G_b0767"/> + <fbc:geneProduct fbc:id="G_b0755" fbc:name="gpmA" fbc:label="G_b0755"/> + <fbc:geneProduct fbc:id="G_b3612" fbc:name="gpmM" fbc:label="G_b3612"/> + <fbc:geneProduct fbc:id="G_b4395" fbc:name="ytjC" fbc:label="G_b4395"/> + <fbc:geneProduct fbc:id="G_b3493" fbc:name="pitA" fbc:label="G_b3493"/> + <fbc:geneProduct fbc:id="G_b2987" fbc:name="pitB" fbc:label="G_b2987"/> + <fbc:geneProduct metaid="meta_G_b3956" fbc:id="G_b3956" fbc:name="ppc" fbc:label="G_b3956"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b3956"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653480"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b3403" fbc:name="pck" fbc:label="G_b3403"/> + <fbc:geneProduct metaid="meta_G_b1702" fbc:id="G_b1702" fbc:name="ppsA" fbc:label="G_b1702"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b1702"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1001788"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b2297" fbc:id="G_b2297" fbc:name="pta" fbc:label="G_b2297"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b2297"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652788"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b2458" fbc:name="eutD" fbc:label="G_b2458"/> + <fbc:geneProduct metaid="meta_G_b1676" fbc:id="G_b1676" fbc:name="pykF" fbc:label="G_b1676"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b1676"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1208453"/> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652654"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b1854" fbc:name="pykA" fbc:label="G_b1854"/> + <fbc:geneProduct fbc:id="G_b4301" fbc:name="sgcE" fbc:label="G_b4301"/> + <fbc:geneProduct fbc:id="G_b3386" fbc:name="rpe" fbc:label="G_b3386"/> + <fbc:geneProduct metaid="meta_G_b2914" fbc:id="G_b2914" fbc:name="rpiA" fbc:label="G_b2914"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b2914"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1001678"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b4090" fbc:id="G_b4090" fbc:name="rpiB" fbc:label="G_b4090"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b4090"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653414"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b0722" fbc:name="sdhD" fbc:label="G_b0722"/> + <fbc:geneProduct metaid="meta_G_b0724" fbc:id="G_b0724" fbc:name="sdhB" fbc:label="G_b0724"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b0724"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652853"/> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1673321"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b0721" fbc:name="sdhC" fbc:label="G_b0721"/> + <fbc:geneProduct fbc:id="G_b0723" fbc:name="sdhA" fbc:label="G_b0723"/> + <fbc:geneProduct metaid="meta_G_b0728" fbc:id="G_b0728" fbc:name="sucC" fbc:label="G_b0728"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b0728"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652018"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b0729" fbc:id="G_b0729" fbc:name="sucD" fbc:label="G_b0729"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b0729"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1653466"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b2464" fbc:name="talA" fbc:label="G_b2464"/> + <fbc:geneProduct metaid="meta_G_b0008" fbc:id="G_b0008" fbc:name="talB" fbc:label="G_b0008"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b0008"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1651885"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct metaid="meta_G_b2935" fbc:id="G_b2935" fbc:name="tktA" fbc:label="G_b2935"> + <annotation> + <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> + <rdf:Description rdf:about="#meta_G_b2935"> + <bqbiol:is> + <rdf:Bag> + <rdf:li rdf:resource="https://identifiers.org/ncbiprotein/1652388"/> + </rdf:Bag> + </bqbiol:is> + </rdf:Description> + </rdf:RDF> + </annotation> + </fbc:geneProduct> + <fbc:geneProduct fbc:id="G_b2465" fbc:name="tktB" fbc:label="G_b2465"/> + <fbc:geneProduct fbc:id="G_b3919" fbc:name="tpiA" fbc:label="G_b3919"/> + </fbc:listOfGeneProducts> + </model> +</sbml>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/textbook_model_cobrapy_exchange.csv Fri Dec 13 21:34:04 2024 +0000 @@ -0,0 +1,21 @@ +reaction_id;reaction_name;reaction_stoichiometry;lower_bound;upper_bound +EX_ac_e;Acetate exchange;ac_e --> ;0.0;1000.0 +EX_acald_e;Acetaldehyde exchange;acald_e --> ;0.0;1000.0 +EX_akg_e;2-Oxoglutarate exchange;akg_e --> ;0.0;1000.0 +EX_co2_e;CO2 exchange;co2_e <=> ;-1000.0;1000.0 +EX_etoh_e;Ethanol exchange;etoh_e --> ;0.0;1000.0 +EX_for_e;Formate exchange;for_e --> ;0.0;1000.0 +EX_fru_e;D-Fructose exchange;fru_e --> ;0.0;1000.0 +EX_fum_e;Fumarate exchange;fum_e --> ;0.0;1000.0 +EX_glc__D_e;D-Glucose exchange;glc__D_e <=> ;-10.0;1000.0 +EX_gln__L_e;L-Glutamine exchange;gln__L_e --> ;0.0;1000.0 +EX_glu__L_e;L-Glutamate exchange;glu__L_e --> ;0.0;1000.0 +EX_h_e;H+ exchange;h_e <=> ;-1000.0;1000.0 +EX_h2o_e;H2O exchange;h2o_e <=> ;-1000.0;1000.0 +EX_lac__D_e;D-lactate exchange;lac__D_e --> ;0.0;1000.0 +EX_mal__L_e;L-Malate exchange;mal__L_e --> ;0.0;1000.0 +EX_nh4_e;Ammonia exchange;nh4_e <=> ;-1000.0;1000.0 +EX_o2_e;O2 exchange;o2_e <=> ;-1000.0;1000.0 +EX_pi_e;Phosphate exchange;pi_e <=> ;-1000.0;1000.0 +EX_pyr_e;Pyruvate exchange;pyr_e --> ;0.0;1000.0 +EX_succ_e;Succinate exchange;succ_e --> ;0.0;1000.0